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Let us know when your receive great advice so we can thank our lawyers and point others with similar questions in the right direction.Got it!
My truck was parked legally, there was a witness who called police but they didn't get a truck number and would not leave their name, but the call is on file
You are in a tuff situation. I would call the police and see if they will do a report and an investigation. This is a long shot since it is property damage only but the driveou up r has committed a crime by leaving the scene of the accident. I would canvas the neighborhood and see if you can find any witnesses. I would also report the accident to Domino's corporateand see if it happened to be reported. If there was damage to the truck there should be a record of it. The last option is to file in small claims court, but you will need more evidence to be successful. Good luck.
The author of this posting is licensed to practice law in the Commonwealth of Kentucky. This posting is intended to provide general information only, and is not intended to provide as legal advice in connection with any specific case or fact situation, and does not create an attorney-client relationship. For specific legal answers you should consult with an attorney.Ask a similar question
Why not just report it to your insurance company as a hit and run. Then I would contact the local Dominos in the area you were hit and request the name of the driver on the date of the crash. If the manager does not want to give you this information then I would contact the franchise owner or corporate and give them the date and address of the location and tell them that their driver hit your car and left the scene. If you have a deductible then ask for reimbursement.
Good luck.
DISCLAIMER: David J. McCormick is licensed to practice law in the State of Wisconsin and this answer is being provided for informational purposes only because the laws of your jurisdiction may differ. This answer based on general legal principles and is not intended for the purpose of providing specific legal advice or opinions. Under no circumstances does this answer constitute the establishment of an attorney-client relationship.Ask a similar question
If you know who hit your truck, why don't you report the incident to the police? Or, report it to the truck driver's company. You can also report it to your insurance carrier.Ask a similar question
Domino's dispatcher knows exactly which truck made a delivery to a given address on any given date and time. With the police report, your insurance should be able to secure that information from Domino's. Whether this makes sense is going to depend upon the cost of repairs which you do not state. The cost of your deductible is all that is at stake. Good luck.
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Residents and crews are working to clear debris in the aftermath of an EF-2 tornado in McMinn and Polk counties.
McMinn County resident Amber Newman was a week shy from her due date when the tornado hit on Wednesday morning.
"After it happened, she wasn't moving or anything," Newman said. "That really had scared me. I thought something had happened."
Shortly after the tornado, medical staff at Starr Regional Medical Center in Athens performed an emergency C-section on Newman to deliver a healthy baby girl.
Newman was one of seven people inside of her home who survived the tornado. Newman, her mother April and family members gathered for shelter in a bathroom. The tornado took and tossed their home, which now lies in pieces.
"It just keeps replaying. I just keep asking myself what I could I have done different?" April Newman said. "There's nothing. Nothing that I could've done different."
April Newman said she held onto one of her babies and prayed.
The Newman family has a home someone is letting them stay in until they get back on their feet.
Wednesday's tornado hurt 20 people and damaged 30 structures. Two people died in a separate EF-3 tornado in Polk County.
Photo Gallery: Storm damage in East Tennessee from tornadoes and severe storms
Map: Click here to view the National Weather Service's tornado database
More: Two killed in EF-3 tornado in Polk County


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English dictionary; photo by Simon Robertson on Flickr (noncommercial use permitted with attribution / share alike).
Illinois designated English as the official state language in 1969 (one of the first states to make English the official language). Many states now recognize official state languages; usually English, but two states recognize American sign language as an official language, and Hawaii recognizes native hawaiian as an official language of the state.


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Doctors on shows such as Grey's Anatomy used inappropriate techniques to treat seizures in 46% of cases, a recent Canadian study found. NYC ER doctor Tamara Kuittinen, MD, shares other common mistakes, and what you can do if ever faced with a similar crisis.
You may unsubscribe at any time.
Symptom: Choking[pagebreak]
The TV Take: Deliver a few Heimlich thrusts.
You should: Call 911. Then give five swift back blows between shoulder blades, using the heel of one hand, then five abdominal thrusts (the Heimlich) if still needed. Alternate moves until you dislodge the object or help arrives.
Symptom: Unresponsive
The TV Take: Begin mouth-to-mouth CPR.
You Should: Call 911 and start hard, fast chest compressions at a rate of 100 per minute (learn how at handsonlycpr.org) and skip the mouth-to-mouth. Even better, jump-start the heart using an AED if available.
Symptom: Seizure
The TV Take: Stick something between teeth to prevent the patient from biting her tongue.
You should: "never put anything in a seizing patient's mouth!" Kuittinen says. Instead, clear away potentially dangerous objects nearby. After the episode passes, turn her on her side to prevent choking.Tags: Doctors & MedicineCopyright © 2017 Rodale Inc.
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Entry requirements
Consideration is given to candidates with a first or second class single or joint Honours degree in Psychology (or a closely related subject).
Months of entry
Course content
The University has a long history of face research. Our internationally renowned team of experts study almost all aspects of face perception, including low level visual processing, adaptation, gaze perception, social perception such as mate preference and attractiveness, mechanisms of recognition and forensic aspects such as unfamiliar face matching and eye witness recovery of memories for faces. This research has led to EvoFIT, a unique system for constructing facial composites of offenders by witnesses and victims of crime, which has a suspect identification rate ten times higher than traditional methods used by police. You will become part of this vibrant research community as you study the key research methods related to face research and will put your learning into practice during a month-long placement.
Course Objectives
This course aims to facilitate understanding of this diverse subject, whilst allowing students to focus the majority of their efforts in face research, an area for which Psychology at Stirling has long been internationally renowned.
Information for international students
If English is not your first language, you must provide evidence of your proficiency such as a minimum IELTS score of 6.5 (minimum 6 in each skill), or TOEFL: Listening 23, Reading 23, Speaking 23, Writing 23.
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Hi everybody! Back once again for another MyIGN birthday cake blog! This time please go say a big happy birthday to Mr. Winzen_Tween! Now his avatar has been Felcia from Darkstalkers for the longest time and he said he likes art, girls, food, space, and catgirls so let's try to find some cakes to celebrate!
Oh wow, this might be harder than I thought and I need turn my safe search on because geez, the things that popped up. Wait, a sec! Found one!
Alright let's try catgirl cakes.... Nope, nothing... uhhh Catwoman? She's kind of a catgirl right? Sure, let's get her in here!
And some space cakes to keep things classy!
And I found this video of a Felicia cake!
So Happy Birthday Winzen_Tween! Hope you liked the cakes. Have a fantastic day!
And remember, if you would like a cake blog for your birthday just comment on the blog below. Just leave the date and some things you are interested in.
Cake For Everyone! - The MyIGN Birthday List


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Phoebe Berks Health Care Center
Talk to a Family Advisor:
Reviews of Phoebe Berks Health Care Center
MeliGirl November 24, 2012
I am a friend or relative of a resident
Phoebe Berks has all levels of care.... I think it seems like a nice community. HOWEVER --- the memory unit also known as "Village Gardens" is WONDERFUL. The way it is set up is there is a common area in the middle with a TV area and dining area. There are a few other TV areas as well. Off of the dining area they have a nice out door court yard. Residents need a worker to take them out. The unit has a real homey feel. And the staff are excellent and love the patients and take good care of them. They have several activities through out the day geared for people with memory problems. I have real peace of mind when I leave because I know my Mom is being well taken care of.
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An in-depth case study from Canada describes the challenges encountered by a middle-school teacher as he introduced new assessment practices in his classroom. George, a teacher with 18 years' experience, was part of a four-year research project conducted by Canada's Queen's University and the University of Victoria. The goal was to identify practices that enhance a teacher's abilities to assess students' growth and achievement appropriately.
George wished to introduce goal setting, assessment portfolios and student- led parent conferencing in his combined seventh- and eighth-grade class of 27 students. In addition to having a strong interest in new assessment procedures, George acted as both student support teacher and curriculum resource teacher for his school. He was also the school's teacher federation representative. Working in collaboration with George, Cinde Lock and Hugh Munby, Queen's University, found that his attempts to change assessment practices were inhibited by the teaching environment and by his own beliefs about teaching and learning, which did not change significantly over the course of the study.
Despite being actively involved in this in-depth collaborative research, George was not reflective of his own core beliefs about teaching and learning that constrained his implementation of new assessment practices. Lock and Munby suggest that this was due, at least in part, to the many demands on his time in the school environment. From this study, they conclude that even when teachers actively choose to change their practice and have the support of a research team, deeply held beliefs and the school environment can inhibit their ability to change.
Introducing New Assessments
George began by having students set personal goals for themselves and by structuring activities so that students would collect data to show how they had worked to accomplish those goals. However, these researchers report that he did not alter his role or his goals for the class. George's teaching emphasized the importance of factual knowledge and he assessed students on the number of facts they supplied to support their ideas. Both he and his students continued to see him as the authority figure in the classroom. He taught predominantly with whole-class presentations and large-group discussions. He saw his job as the transmission of information, and it was difficult for him to conceive how this affected student- centered assessments. He did not believe he would fulfill his obligations as a teacher if he allowed students to work on their own without his leadership. GeorgeÆs beliefs about teaching and learning remained essentially unaltered throughout the course of this research. He viewed the new methods of student assessment as separate from his teaching. George's unchanging beliefs and his teacher-centered style of instruction conflicted directly with his attempts at student-centered assessment. He wanted students to feel more responsible for their learning, yet he did not relinquish any authority. The busy environment of the school and his additional coaching, disciplinary and supervisory responsibilities interfered with his time to reflect on his practice and to implement the new assessment program. Observations revealed constant interruptions of his instruction and planning time. In addition, there was the burden of accommodating a wide variety of student abilities in his split-grade class.
Lock and Munby conclude that this in-depth study of one teacher's attempt to change his assessment practices confirmed the difficulty associated with understanding and changing teachers' long-held beliefs. George's beliefs did not change even though it was his own idea to change his ways of assessment. George did not understand that the new assessment practices required changes in his behavior as well as his students'. The complexity of the classroom environment was apparent to the researchers in this study. As one researcher wrote, teachers deal with "spontaneous, idiosyncratic, unpredictable, context-dependent, time-constrained, group-influenced learning."
Long-held beliefs make it difficult to mandate new practices
Although George took advantage of many professional development opportunities, his attempts to implement new practices were inhibited by the environment and by his unchanged beliefs. These researchers believe that the difficulties apparent in this long-term study have implications for methods of conducting professional-development programs for teachers. They suggest that mandating new practices to teachers is unlikely to be successful. Even when teachers instigate changes themselves and are provided with professional support and resources, they may find it very difficult to make these changes without altering many other aspects of their teaching environment. p> "Changing Assessment Practices in the Classroom: A Study of One Teacher's Challenge" Alberta Journal of Educational Research Volume 46, Number 3, Fall 2000 Pp. 267-279.
Published in ERN December/January 2001 Volume 14 Number 1


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Small Spinach Frittata
TOTAL TIME: 10 min
- 1/4 cup(s) spinach, frozen
- 3 large egg white(s)
- 2 tablespoon milk, fat-free
- 1 tablespoon cheese, cheddar, low-sodium shredded
- pepper, black ground to taste
1. Thaw spinach in a microwave-safe bowl by heating on high for 2 minutes, covered; press with fork to remove excess water. Place back in the microwave. Cook on high 2 minutes more, covered.
2. Meantime, beat egg whites and milk in a bowl until well mixed. When spinach is done, pour egg mixture over it. Cover the mixture, place back in the microwave and cook until it begins to puff, about 1 1/2 - 2 minutes.
3. Remove and sprinkle with cheese. Cover and let cheese melt. Allow it to sit 1-2 minutes more.
4. Cut into wedges and add pepper to taste. Enjoy.
Nutrition Detailsper serving
Calories 98, Fat 2g, Cholesterol 8mg, Sodium 211mg, Saturated Fat 2g, Protein 14g, Fiber 1g, Carbohydrates 4g


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Cleveland Heaventrain & Lighthouse Inc.
A Nazarene Compassionate Ministry Center, Cleveland Heaventrain is our district's longest serving outreach to the kids of inner City Cleveland. Lighthouse Inc is a 501c3 not for profit organization that was created to help serve the children and their families of Cleveland's Central neighborhoods. For more information about Heaventrain, Storehouse Ministries or the newer ministries of Lighthouse Academy, Lonnie Burton Express youth Basketball, Reality Check youth camps or how to volunteer visit their website or Facebook page or visit their Youtube Channel.
Read the article, One house Many Beams from Nazarene Compassionate Ministries Winter 2012 Magazine.
Stockings for Centrals' Kids | Heaventrain
The mission of Heaventrain is to build meaningful and lasting relationships with children and their families in Cleveland's central neighborhood. We follow this principle every time we go into the neighborhoods. There are times that are a little more special, however, and Christmas in one of them. Christmas Stockings are a personal- ized way of letting the kids know someone loves them. Receiving love plus hearing the Gospel of Jesus Christ prepares children's hearts to potentially accepting the greatest gift of all — salvation.
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· --Donate a filled Christmas stocking following the guidelines below.
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Lighthouse, Inc., Attn: Heaventrain, P.O. Box 602720, Cleveland, OH 44102 or
Go www.heaventrain.org and use the DONATE Now tab.
Suggested Items to fill stockings :
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Hat & gloves (neutral color)
Fun items (silly putty, Pez Dispenser, cards, Stickers, bouncy ball, bubble, etc.)
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Small sandwich bag of wrapped candy
Candy Cane
Christmas card with age appropriate personal blessing(Important)
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Deadline is December 1st.
Cleveland Nueva Luz Urban Resource Center
A Nazarene Compassionate Ministry Center serving the AIDS community of Cleveland. For more information about the various ministries available visit their website.
Remember World AIDS day is the FIRST SUNDAY in December. For more information on how to help or educate your congregration, contact 216.651.8236 or email@example.com
Cleveland Victory
One of the church plants from our flagship urban outreach ministry, Heaventrain. This is a church serving the Cleveland Neighborhood of East 55th and Superior through weekly meals, monthly food and clothing pantry and spiritual worship. For more information how you can serve in the ministry contact Mike Pelley at email@example.com
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Check out their Facebook page or contact Thais Ward for more information.
Christmas Toy Give Away
Scheduled for December 10. Call 740-397-5740 to make other arrangements.Click here for more information.


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Thursday, January 6, 2011
Face the Enemy
48 comments:
Gabriella, you have touched my heart once again. I think you are a brave woman for facing yourself and for doing it with love.ReplyDelete
Ah, Luis - it's easy to be brave when I'm surrounded by such a community of artists like yourself who inspire and sustain me every day with their talents and their kindness.ReplyDelete
For all your claims to the contrary I have only two words for this: Beautiful. Perfect.ReplyDelete
Yeh, well I used to hang out with all these awesome prose writers, you see, and maybe some of that has finally sunk in. Wow, could this one actually shake Z's stance on the literary merits of CNF? Nahhh...ReplyDelete
Um, and thanks.
hey, G.ReplyDelete
I have two friends with vitiligo.......i understand what you've been through and not because of them. I was born with no enamel on my teeth. One in a million. I didn't smile with my mouth open for years. I can feel your pain. Yours was probably much more painful than mine because I could keep my mouth closed but kids were certainly cruel to me and I carried it for many, many years. I got crowns in my twenties ....i was very lucky.
You are inspiring to come out with your story. Don't be afraid to take your picture!! You are a beautiful woman inside and out.
Oh....and btw....your tattoos rock!!!
Wow. Years ago I didn't know ANYONE with vit, now it seems to be everywhere. I do wonder whether it's on the rise (we've poisoned the planet and now it is poisoning us) or people are just being more open about it, and about everything that ails them. Thanks for sharing your own story, M, and the too-kind words! Don't worry, there will be more self-portraits now I've broken through!ReplyDelete
- AnonymousJanuary 6, 2011 at 8:59 PM
Brave, beautiful and inspiring! Encouraging others to speak their truth...you are a blessing.ReplyDelete
Thanks, "Anonymous" K! It's a strange concept to me that I could ever inspire or encourage anyone by my example, but if this is so, it's only fair, after having so many others do that for me with the truths they've lived and shared. Maybe we can all create a better world? Or at least improve our little corner of it. One can dream.ReplyDelete
yes, you crossed a bridge, and is already on the other side!
very courageous in facing the enemy! Brava!
speaking, we are free, exorcise the matter, we are lighter! everything you said, just proves how much sensitivity you have ...
is such, that is visible in their own skin ...
We are pure chemistry and spirit - the question is finding the balance and let the brain work in its original configuration ...
... and your tattoos are great
and make up your identity!
Sei una bella donna, in l'anima e l'aspetto!!
mille baci!
Cara Denise, mille grazie - I read your comment and know you understand me and that makes me smile! I will try to live my life by your words and always be "una bella donna in l'anima e l'aspetto" - to be called this - what more could I ask for?ReplyDelete
Good enjoyment to read your writing.ReplyDelete
Happy Friday to you.
Gabriella, i have been drawn to you by your writing and your art and now like the five who have commented before me the words bravery and beautiful comes to mind.ReplyDelete
for you it is the time for you to come out, to free yourself. how we should all come out when the time is right for us. i feel blessed to be a very small part of your celebration.
lasciate che l'amore del tuo viso splendente
piovere sulle nostre proprie fratture
così possiamo vedere la luce.
Wong, thank you! You have such a good eye and heart I always appreciate that you enjoy my posts!ReplyDelete
Robert. I thought I had resolved this issue already, but like so many things, it took one more look and final push to really break through. How good that it could happen in such good company, how good that it feels more like a sign of future growth than past closure! And thank you for the Italian words. They always sing to me more deeply than English even if I can't carry on a conversation in Italian. That word - lasciate - even more than l'amore - has such resonance for me, for readers of Dante especially. But it means so much more than any English equivalent. Abandon is how it is always rendered. But it's more about setting aside, letting go. Thank you, my friend. Best to you, caro.
Dear Gabriella,ReplyDelete
I have been reading your post, going through all kind of emotions, it made me very quiet.
Brave, courageous, yes certainly.
And yes all the imperfections we have can be used to bring good things, they make one to dig deeper, find other ways, go to the bottom and search for a way to get out again. It's hard but enriching, coming to places unknown to many of us.
I know, meeting someone new we all look at the persons outside. But that image changes when I get to know someone better, no matter looks, someone can become very beautiful in my eyes because the inside is soo important. The way a person makes you feel, in the end, has nothing to do with looks. But for some people it takes a lifetime to see this and some keep holding on to only the outside 'till the end.(that are not really the ones i want to spend my time with)
To me you are a very talented, beautiful woman, you have interesting things to say and I like your sense of humor and the photos in this post are special and beautiful. Love renilde
Thanks for opening up and sharing this. This post might really help someone who is struggling with some of the issues that you've delt with and continue to deal with.ReplyDelete
My wife used to go to a Lupus support group in the 1990's but she said that it just turned into a big "pity party" after a while.
You really are a good poet and photographer and that's for keeps, but even the most flawless faces out there are going to deteriorate sooner or later. :)
G! You're confidence and sense of yourself, even as it grows and changes is such an inspiration! If we cannot be ourselves and trust that there are others who will always be true to us, no matter who we are....well, what's the point! This will be the year for you! And that poem is quite beautiful too! Thank you, once again, for a post straight from your heart and your gut...always an inspiration to so many of us.ReplyDelete
Renilde, thank you for your words - I think it's true, sometimes the things that drive us inside ourselves turn out to be great blessings and help us develop inner strength, which is so much more important than a pretty face! And yes, I've noticed too that the people I love, I don't really see how they look anymore, because when I look at them I see everything they are on the inside and everything they make me feel.ReplyDelete
James, that would be great if this post could help someone get past some of the shame and self-consciousness and be their beautiful selves! Yes, sometimes support groups help, but other times it seems to me they isolate you even further. I'd rather find a way to comfortably and proudly be in the world than another place to hide and be comforted by others who are also "different." Sorry to hear about your wife's illness. I hope she's doing okay?
Patti - like everything else, this is an ongoing journey, but I like where I am right now - definitely further to go, but a lot of bad road behind me, the worst of it over and done! The flinch factor when I see my own image has definitely declined over the years. At this point it may not be the face I'd like to see, but what can I do about it? In the past, loved ones have told me that after a while they don't even see it anymore, that I see it and care about it a lot more than they do! It's good to have people like that in my life, who see with their hearts. Many thanks for your comment, my friend. Be well.ReplyDelete
the confidence of denial...so interesting put that way. I have done this, though had no words for it.ReplyDelete
Your photo shoot reminds me of an art exhibit I once saw. A photographer had taken a full length nude photos of herself once a year for 40 years. Same front pose. Same side pose. Same woman. Aging. I thought how brave to be so transparent, and how it allowed gravity to become beautiful and artful.
You have done the same thing here, with pigment. Thank you.
WW - I was hoping to get across that denial can be put to good use sometimes, if the only way to move forward past some inner or outer obstacle is to temporarily suspend belief in it! I absolutely love the art exhibit you describe! An aging woman is beautiful - but they know that in Europe, it's America that has this obsession with the perfect ageless woman!ReplyDelete
Thanks for your comment, always good to see you here!
I am afraid that my English is not good enough
to explain you only in a few words, that I am
looking up to you!
I have read all comments from your friends and
everyone is saying this in a different way.
You are a very brave and so intelligent woman.
Yes, writing about a health problem is a kind
of a cure!
With all my love to you,
Monika, I always understand you perfectly! Thank you so much for your words, and for making the effort to write in English when it is not your best language! I do appreciate it. I send my love to you from far away!ReplyDelete
i rarely read long posts on blogs (come to that, i rarely read) but your post kept me hooked as i walked in your life by your side... you have a beautiful face... i should know, i spend most of my time looking at them and beyond;)ReplyDelete
Thank you so much, Rahina! I'm glad you enjoyed this post and that it kept you engaged! Your comment does mean a lot coming from someone with such great experience and talent at capturing both the inner and outer beauty of faces! Be well.ReplyDelete
I really love that you've turned your vitiligo into art. Now that I am in my sixties, I find that I don't care much what people think. If I had vitiligo I might be tempted to have a lot of pictures of my face put on a T shirt with the contrast emphasized. Most things in the material world are artifice anyway.ReplyDelete
I think you are beautiful.
Dear Gabriella,ReplyDelete
your writings are so intense and all your posts touch my heart every time. Again and again. Thank you for being so open,for telling us about facing your enemy, it's so inspiring.
Your self-portraits are beautiful!! And i notice you have the neck of a ballerina. :-)
Maybe you can check the blog: the body, nothing else. It's about female artists, telling about their changing bodies. I think Ria (who started this blog) will be happy with your story/input.
I didn't want to, but i'm blablaing too much. Because i think after this great post, these inspiring words there's only one answer; Silence and respect.
Sweet greetz and kisses for you, Monica
Kass, I like your t-shirt idea! Not caring as much what people think is one of the best things about getting older!ReplyDelete
Dear Monica! To be able to touch your heart with my writings makes me very very happy. I will check out the blog you mention. Hah! I think my neck is probably the only part of my body like a ballerina! Kisses for you too, sweet one.
Hi G/TT - as ever, your post stopped me in my tracks and I had to come back a day later - I went away to ponder, as is my want. Skin colour or lack thereof, poses one of our biggest challenges to seeing humanity and its an extra tough call when your face starts messing with you. Somehow, like all the others I think the best of us go beyond the surface and see the person. But the less than best of us don't and that must have made your journey very sad and difficult at times. My sense is that you are well and truly out the other side of the tunnel - and I am happy to celebrate and share that with you, although I honour your path through the tunnel. Go well, be well.ReplyDelete
Gsbriella, I can only mention i have also some scars in my body that led me many times to depression first and to anger later. The worst was they were produced because of some other people´s supidity. Anyway, like if my memories of my youth and childhood weren´t bad enough, i had to deal with such horrible scars across my body surface. Until one day someone told me about cristal and swords. The first has to be handled with care and affection, they are fragile and fall to pieces easily. The swords are born at the fire of the furnace and the iron of the hammer. They are forged on a hostile cradle. Cristal are kept inside a show case, they break easily into crumbles. Swords can become invencible, they were made for winning in battle and for being admired. I admire you, powerful yet sensitive and poetic sword, with a big heart.ReplyDelete
My warmest regards and a big hug Gabriella.
Hi Fiona - yes, I've often thought of the similarities and differences between others being judged by their skin color, and me by my lack thereof! The big difference, I suppose, is that being denied a place in society is a lot worse than getting funny looks on the street. Still, I have a keen awareness of what it feels like to worry that someone will alter their opinion of you once they get a good look at you. But you're right - I'm out the end of the tunnel! Many thanks for your taking to heart and spending time thinking about what I write! Be well.ReplyDelete
Alberto - I am sorry to hear about the scars you bear. We all have damage on the inside, but it is hard to have it outside for all to see. It's strange you mention swords. The first tattoo I got, and the beginning of my reclaiming my body as something to be proud of, scars, discolorations and all, was of a raised sword! Many thanks for your kind words.
Gabriella this post gives hope and healing to anyone and everyone, no matter the affliction...thank you. You accept what you cannot change and move on with your life. You are a brave and beautiful lady...inside and out.ReplyDelete
Your poem was so beautiful. Again, I thank you for sharing it with us.
My grand-son is a tattoo artist and I marvel at the detail and beauty in the designs and colors that he creates.
I visited your blog through William's posting so I would like to thank him too.
All the Best,
Your work, your words and now your honesty totally inspire.
You are appreciated :)
Your artistic comrade,
well I know about auto immune disorders, I have one also, mine is just not as visible as yours. personally, I think you look beautiful and these photos prove it! ciao bella!ReplyDelete
JAN - many thanks for the kind words and for following me all the way here from William's blog, which is as good a referral as it gets! I have such great respect for tattoo artists like your grandson! The human body, even in great shape and with its owner being very well-behaved, is not an easy canvas to work on! All the best to you.ReplyDelete
DOUGLAS - Comrade! So glad to be appreciated. Sure took long enough, but better late than never!
DOLCE VITA- Welcome to my blog! So good of you to visit, and many thanks for the compliments! I am sorry to hear you have an autoimmune disorder too. I hope it doesn't interfere too much with your life - it obviously hasn't dampened your spirit! Be well.ReplyDelete
I think that the most important thing in our life is to have a healthy, open soul!ReplyDelete
Everything else is not very important as soon as you can manage ( in a way) the situation. And I trully believe that somehow we all have something to hide outside or deep inside and it is not fair!
I am amazet about your courage and I want to congratulate you ( sorry for my english)
My compliments, my friend!
My best regards from Romania!
Greetings, Wind! Thank you for visiting me. Everything you say is so true, your words mean a lot to me. I just looked at your blog and the first photo from your Jan 7th posting reminds me of a window image I once took, the view from the inside out, as it were, a very rich theme to explore! I like your work very much! Be well.ReplyDelete
Thank you, Two Tigers!ReplyDelete
I wish you a great week !
Best of my thoughts from Romania!
Gabriela, your writing here is stunning. Work like this is one of the reasons I love to blog. We meet the most amazing people. Your affliction is also your strength, all credit goes to you for dealing with it as you do.ReplyDelete
I'm new here via a blog friend on FB, most likely someone like Two Tigers, sometimes I just follow threads where they lead. It's such a treat. thank you for this extraordinary 'self-portrait'.
Of course it's only half the story. there's so much more to you than your face, but how preoccupying our faces become, they are our first point of contact with the world.
Thank you so much, Elisabeth! Your blog too inspires me with the positive possibilities of the medium!ReplyDelete
"Pale hands I loved so well" from Coil is floating trough my head while reading your words just as one flower is opening in front of my eyes to a brand new beautiful flower,you, Gabriela!ReplyDelete
Hi,my name is Aleksandra and Im not so brave as you are,I think!
Pleased to meet you ( via Mr.Michaelian) :O) and learn of your many talents,and pardon my language cause Im still learning English!
Have a wonderful week,loads of good love and smiling smiles!
I'm so sorry that on this post, I am late ...ReplyDelete
I was away for Christmas by my parents and my partner and I disconnected totally from the Internet er 2 weeks ...
I lost many things here in our blog world, like your book (which I plan to go further calmly) that I saw posted on the blog of Caio,
are increasingly happy to have known you and I admire the way you are
Hello, Aleksandra! It was so good of William to tell about me on his blog and send his friends to visit! Your English is very good! I am always so grateful and impressed when people still learning English make comments here and do their best to use my language! I may be brave, but I'm not brave enough to try to leave a message for you in YOUR language! Many thanks for your kind words. Have a great week!ReplyDelete
LAURA! I'm so glad you're back from your holidays! I hope you had a wonderful time. I can't imagine how much catching up you have to do on Blogger after 2 weeks! If I stay away 2 days it's like an avalanche of messages to dig out from! I am so happy you came here to visit me and leave such kind words. All the best to you!ReplyDelete
I can't belive that i lost a post of yours again .ReplyDelete
wow !!! this is really something.
to read this post is a battle by itself . Incredible . It is becoming so common in the world today , I bet the researches , with were better done , would prove that in the global life style something is cousing this . Maybe some product we have consimed , or wat to treat water , or ar.... who knows. as it isn't genetic infectious.
well , you hace tree sking , the natural one , the spoted one and the tattoed one . 3 levels and even so your souls is visible to everyone !
simcerely , i liked to see your face , it is the first time i see it well... you are pretty .
Brian Brian ..... lucky guy.
I liked the poem , it is direct , i have apreciated your style .
well... thank you for this master-piece-post , again ! your blog is with no doubt one of the more intences and better to read .
kisses !
Hi Caio! I was wondering where you were! Thanks for the kind words, I'm glad you enjoyed this. I guess we are all starting the year off in a big way, you with your baptism, and me with my first intense post of 2011! Artists must always be ready, willing and able to take a big step in life, one that is a declaration and celebration of the new life to come, whether it is a spiritual or a personal rite of passage. All the best to you, my friend!ReplyDelete
You're beautiful, inside and out, but truly, it's the inside that matters most - the most. I applaude your post and bravery in facing issues that have been hard for you - some never do this their whole life.ReplyDelete
T - if you had told me years ago that one day I would publicly post explicit photos of my skin condition online and be called both brave and beautiful, I'd have never believed it! This has been quite an experience, and possibly a whole new direction and philosophy for my work. It's good to have the support and inspiring influence of so many good artists. Many thanks for your comment!ReplyDelete


text:
First Snowden Systems and Industrial Corporation is a Filipino Engineering/Construction company committed to achieving customer satisfaction by providing reliable and responsive service in the design, supply, manufacture and construction of cleanroom systems. We are the only local cleanroom company which is ISO 9001 certified.
Education : Graduate of Mechanical Engineering course preferably with
professional license but not required.
Experience : Two to three years in warehouse/industrial construction projects.
Experience in designing HVAC, Chillers, and energy/building management.
Skills : Skills in applying supervisory techniques.
Others : Result-oriented, motivating and coaching.
Reports to:
Engineering Manager/Project Management Head
Primary Responsibility:
Performs engineering duties in planning and designing tools, engines, machines, and other mechanically functioning equipment.
Specific Responsibility:
1. Reads and interprets blueprints, technical drawings, schematics, and computer-generated reports.
2. Confers with engineers and other personnel to implement operating procedures, resolves system malfunctions, and provides technical information.
3. Specifies system components or directs modification of products to ensure conformance with engineering design and performance specifications.
4. Provides feedback to design engineers on customer problems and needs.
5. Develops, coordinates, and monitors all aspects of production, including selection of manufacturing methods, fabrication, and operation of product designs.
6. Plans and directs engineering personnel in fabrication of test control apparatus and equipment and develop procedures for testing products.
7. Selects or designs tools to meet specification using manuals, drafting tools, or computer assisted design/drafting equipment and software.
Apply personally at FIRST SNOWDEN SYSTEMS & INDUSTRIAL CORP. UNIT A BPI BLDG. 177 DOÑA SOLEDAD AVE. BETTER LIVING SUBDV. PARAÑAQUE CITY from Monday - Friday, 9am - 3 pm or send resume / bio-data at email address . For inquiries, please call 822-2791 / 822-6814 or 09228341835 / MARK
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text:
We have Nolens Volens on the show tonight which will be great, but in honor of Local Music Thursday, I thought I would highlight something from a great new website called SnagFilms.
It's a new venture from former AOL honcho Ted Leonsis, and it's pretty amazing. For example, you can watch the Sundance hit documentary Dig! about the battle between the Dandy Warhols and The Brian Jonestown Massacre.


text:
Cruise Planners/American Express, the nation's largest home-based travel agent franchise network in the cruise industry, is hosting an exclusive sale June 22 - 29 on all Royal Caribbean bookings for itineraries sailing July 1 - December 31, 2009.
The sale includes all gratuities for the first and second guest per stateroom and 50 percent reduced deposits. Additionally, Cruise Planners' offers can be combined with any Royal Caribbean promotion during the sale period such as discounts of up to $200 per stateroom and up to $150 in on-board credits, based on the length of the itinerary and sailing date.
"Cruise Planners wants to make cruising, already one of the most affordable ways to travel, even more valuable for our customers," said Michelle Fee, Cruise Planners co-founder and CEO. "As Royal Caribbean's Home-based Partner of the Year, we've teamed up to offer spectacular savings, plus incentives travelers can really appreciate, like picking up the tab for gratuities, which can really add up. This sale is our way of saying thank you to our customers for 15 very successful years."


text:
Sonata Coat by Nanette Lepore
i LOVE this coat by Nanette Lepore, and the colour
I love a toggle. This is a great, lightweight parka.Added 8 Years Ago from My-wardrobe
This jacket is sweet, and you definitely won't be missed in a crowd. I really like the toggles.Added 8 Years Ago from My-wardrobe
this alexander mcqueen coat looks so cool zipped up because it's got an exposed zipper.Tags: fashion, style, jackets, coats, Alexander McQueen, mcq, exposed zipperAdded 9 Years Ago from My-wardrobe
i love the swingy, dramatic look of this. this aint no ordinary cardigan.Tags: fashion, style, cardigans, swing, coats, wide collar, Day Birger et MikkelsenAdded 9 Years Ago from My-wardrobe
double-breasted wool cape from thomas burberry. this looks like it came out of one of my favorite children's books, "the worst witch."Tags: fashion, style, wool, capes, witch, coats, double breasted, thomas burberry, worst witchAdded 9 Years Ago from My-wardrobe
what a weird and cool trench. you could wear this as a jacket or as a dress.Tags: fashion, style, dresses, jackets, coats, trench, avant garde, pringle of scotland, shrunkenAdded 9 Years Ago from My-wardrobe


text:
ST. LOUIS — Ever wonder what a real Major League Baseball base looked like underneath? Regardless if the answer is yes or no, you do now. But these bases, like the one in the photo above used for Game 3 of the NLCS, are a little different. They've been retrofitted with microphones so Fox can better pick up its "Sounds of the Game." The microphone is located under the rectangular metal plate, screwed in on the right-hand side.
The worker in the photo was checking each set of bases made by Schutt Sports (there are at least two full sets) during batting practice to ensure the sound was coming through clearly. A technician on the other end of the microphone would advise him if the base sounded "dirty" or "clean" and the worker would whack the base and blow into it — really — to clean it out.
As he was finishing, Marco Scutaro of the San Francisco Giants saw him and asked if he were "blowing it up" like a balloon. Oh, you, Marco!
In case you're wondering what the writing on the sticker says, I transcribed one of them:
The purchaser and/or installer of this product is responsible for advising the end user of the possibility of injury while sliding into the base. The installer and/or purchaser shall read and follow safety and installation instructions packaged with this product.
Extra caution should be taken to ensure anchors are clean and base rests properly on playing surface. Under no circumstances should play commence when bottom of base is standing above playing surface. Injury may result.
Do you think anyone actually talks to the major leaguers about the dangers that sliding into bases presents? Maybe it happens during spring training? Anyway, as to the other sticker, it is a warning that the base should not be used in wet or icy conditions. And there's something about a "clear and present danger" to sliding somewhere (home plate?) but I don't know what it says because the post is in the way. Sorry.
Love baseball? Enjoying the postseason?
Follow @AnswerDave, @bigleaguestew, @KevinKaduk on Twitter,
along with the BLS Facebook page!


text:
Putting precious time into planning for a natural disaster may seem like a low priority. It shouldn't — fires, floods and earthquakes can strike at any time. Unless you plan ahead, they pose a huge risk to your business.
Before you draw up a disaster recovery plan — also known as a business continuity plan (BCP) — think about what your business will need for it to keep trading.
Those needs may change as you move from business survival mode in to recovery and then a return to business-as-usual. Some things may not be so important in the short term, eg premises, if staff can work from home.
Premises: Could staff work from an alternative site or home if your current premises can't be used? Ask your main suppliers, customers — even competitors — if they could spare room in their premises.
Staff: If you have staff, could your business continue without some or all of them? List the main duties of all staff — or, better still, get them involved by doing it themselves.
Transport: If your business uses transport to deliver products or services, being without it is a huge risk. What are the alternatives? Can you rent vehicles? What if the port, airport, road or rail system is disrupted? Could customers come to you in the short term?
Equipment: If you rely on your own equipment to make products, eg as a bakery relies on ovens to bake goods, could you borrow or rent alternative equipment or premises?
Computers/printers: Could your staff use their own computers and printers for work if business computers are out of action? Find out who has them — the business can reimburse them for internet use.
Files: Access to your business data — customer details, emails, files and spreadsheets — will be critical to your business survival. If you store data in the cloud, you can access it anytime and anywhere there's an internet connection. Make sure at least one copy of your data is stored offsite. Read more about Storing and protecting data.
Customers: You'll need to keep talking to customers after a disaster. Ask yourself what's the best way to contact customers. How will they contact you if phone systems are down or you've relocated?
Cash: Small businesses usually have better uses for cash reserves than putting it aside for disasters. Talk to your bank manager about how to manage cash flow through a disaster, eg how you'll pay suppliers, rent and staff if you have to stop or scale back trading.
Note what you've learned from compiling the list of disaster risks in the previous section. You can now look at what to do during and immediately after a disaster.
What will you and your staff do if a disaster strikes during business hours? Your plan needs to include:
Staff evacuation: Be clear about the procedure to follow in an emergency. Make sure staff know what to do in case of:
Assembly: Decide on a safe place to congregate that's close to your premises. In a major crisis, staff will want to be with there families. So, make a planfor staff to leave and check on family and friends.
Wardens: Make specific staff wardens responsible for counting all employees and visitors, eg sub-contractors and clients, after an evacuation. Have alternates in case of absence.
Contacts: Compile a list of relevant contacts, eg emergency services, clients, suppliers and your insurance company.
Welfare: Have a procedure to handle injuries. There should be a medical kit on hand for minor injuries. Identify the nearest medical facility for anything more serious.
Safety: Make sure you have a plan for contacting staff to let them know when and where to report to work. Plan for an alternative premises or work arrangements if it's deemed unsafe.
Assess your need to stock emergency supplies. If you're in a remote location it's worth thinking about installing a Civil Defence cabinet. These are designed to hold emergency supplies, eg water, blankets, rope, torches, dust masks and gloves.
Earthquake procedures (external link) — Civil Defence
Get ready for a disaster at work (external link) — Civil Defence
Guide to suggested supplies (external link) — Civil Defence
Don't let your plan gather dust on a shelf. It must be a living document that gets updated as your business grows and new information comes to light.
Run test drills: Schedule dry runs regularly, but also throw in drills without notice. Discuss how these went and improvements you can make. Use different scenarios to cover fires, earthquakes and other hazards.
Discuss the plan with staff: Get all staff involved in talks about emergencies. Make sure everyone is clear about their roles and what they should do.
Set up a team: Assign the job of looking after the disaster plan to a team — preferably drawn from across your organisation. It can lead all-staff discussions and keep the plan updated.
It's normal for businesses to find trading hard if not impossible during and after a disaster. That's why you must plan in advance how your business can recover and return to normal if disaster strikes.
Tips on business continuity planning
The size of smaller businesses and their ability to adapt quickly to change can be huge advantages after a disaster. However, small businesses are less likely to have money in the bank to get them through periods when they can't trade.
For small businesses, it's important to build relationships with other businesses, eg suppliers, and the wider community to call on when in need. To find out more about how to make your business more resilient, visit the Resilient New Zealand website. (external link)
There may be many options apart from closing your business, including:
Investigate all options and only think about close down as a last resort.
If it becomes impossible to keep your business running you may want to lay off or stop paying employees. Like closing down, this should be a last resort. For more information, our Employment Agreement Builder covers major natural disasters in the force majeure clause (external link) .
Check what cover your business has in the event of a natural disaster. Give attention to:
Contents: Replaces your office supplies, computers — anything you can quantify.
Building: Replaces the work premises if you own it.
Business interruption insurance: This policy is designed to keep your business open through a crisis, even if it stops trading. It can cover things like:
Talk to your insurer about the different options available.
We want to provide relevant and useful tools, tips and advice to save you time and money. Your feedback will help us understand whether our site is delivering the sorts of information you need to succeed.


text:
Toronto, ON – On Dec. 23 2016, Toronto artist Sean Leon blew up the Internet by releasing an incredibly in-depth interview with … Read More »
Archive Tagged 'ixxi'
Sean Leon fires back at Jazz Cartier on "FAV RAPPER / HUNDRED MILLION RELIGION"
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Daniel Caesar of IXXI releases new singles: "Get You" ft. Kali Uchis & "Japanese Denim"
Toronto, ON – Just prior to heading out East for the Halifax Pop Explosion 2016, IXXI's Daniel Caesar released a pair of … Read More »
Daniel Caesar came to Vancouver and everyone is talking about his euphoric performance
Vancouver, BC – This fall we've been lucky enough to witness an ample number of rising Canadian talents make the trek to the West … Read More »
Listen to the new Dripset Vol. 1 mix from Sean Leon & IXXI's official DJ, Jordan Fall
Toronto, ON – You won't want to miss the Dripset Vol. 1 mix from Sean Leon and The IXXI Collective's official DJ, … Read More »
VNCHY gave us the breakdown of his new single release "No Kobe"
Toronto, ON – Toronto artist VNCHY just released this new track titled "No Kobe" as his fourth single release of the year. … Read More »
Sean Leon holds his own during intimate show in Vancouver
Vancouver, BC – From legends like Erykah Badu and Quest Love to big name Canadian artists like Tory Lanez and Majid Jordan, … Read More »
Sean Leon teamed up with Milly Manson & Eestbound for "XXXCITED" & you need to hear it
Toronto, ON – Originally published July 18, 2016 – As he gears up for the highly anticipated release of Black Sheep Nirvana … Read More »
Sean Leon hits Vancouver for pop-up show August 6th
Vancouver, BC – It's not hard to tell the HHC team has been riding with the come up of Sean Leon from time. … Read More »
Zane Lowe premiere's River Tiber's new record featuring Daniel Caeser
Toronto, ON – Fresh off yesterday's premiere on Zane Lowe's Apple Music Beats Radio 1 show, here's the new single from singer-producer … Read More »
IXXI's Daniel Caeser enlists BadBadNotGood & Sean Leon for "Paradise"
Toronto, ON – Daniel Caeser, BadBadNotGood and Sean Leon on one record… "Paradise." Daniel Caesar's Pilgrim's Paradise is available on iTunes.
Sean Leon of ixxi's Kobe Bryant-influenced single, "81" is our Song of the Day
Toronto, ON – New music from rising star Sean Leon of the ixxi fam. This is "81," produced by Eestbound, paying homage … Read More »
Sean Leon – This Ain't 2012 (Prod. WondaGurl) [Audio] #SOTD
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Sean Leon – King of the Wild Things [Mixtape]
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Sean Leon – September 7th [Audio]
Toronto, ON – New music from up-and-comer Sean Leon aka Maui Slim. This is "September 7th." Peep it.
Sean Leon – Narcissus, Drowning of Ego [Mixtape]
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Daniel Caesar – Birds of Paradise [EP]
Toronto, ON – The iXXi is, undoubtedly, a collective filled with talent. Now, The iXXi gives us to singer, Daniel Caesar, who … Read More »
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Sean Leon – Killer [Video]
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text:
|Battle of the Burning Wall
| Location:
Kaiu Kabe
| Date:
| Major Forces:
Crab, Unicorn, Lion
| Generals:
Hida Kuon,
Akodo Shigetoshi,
Rakshasa General
|Battles of Rokugan
The Fall of the Wall was the first battle of the Destroyer's Horde at Rokugan.
Preambles Edit
In 1171 a huge wave of Oni and other Shadowlands creatures attacked the Kaiu Wall, seeking to flee from something more dangerous deep in the Shadowlands. [1] The assault was relentless as it seemed like the entire Shadowlands had emptied in the attack. [2] The Crab asked aid to keep safe the Wall and the Lion Clan Champion Akodo Shigetoshi joined the defenders alongside with the Utaku Daimyo Utaku Yu-Pan. [3] The Shadowlands assaults took a heavy toll on the Crab forces. [4]
Destroyer's Horde attack Edit
Bolstered by the Unicorn and Lion reinforcements, the samurai were able to hold the Wall. However, this was just a prelude to the real battle to come as just behind the Oni hordes were the armies of the Destroyer, fresh and ready for battle, led by a tiger-like demon, the Rakshasa General. The Crab Clan Champion confronted him in a personal duel, but he could not match the shapeshifting abilities and supernatural powers of the Rakshasa. Kaiu Taru interceded and convinced Kuon to leave. Taru exposed a jade and gunpowder cache and dropped a torch into it, detonating a large section of the Wall and wounded the Rakshasa. [5]
Aftermath Edit
The Destroyers overwhelmed the exhausted samurai and breached the wall, letting hordes of Destroyers pour into Rokugan. [5]
Known casualties Edit
|This battle related article is a stub. That means that it has been started, but is incomplete. You can help by expanding this article.


text: 13 photos $3,495,000 1.61 acres 180 Vineyard Road, Cotuit, MA 02635 - Barnstable County 1.61 acres Cotuit, MA In the Charming village of Cotuit sits this unique waterfront lot.Build your dream home on the south side of the Cape and swim from your private sandy beach .This area is one of Cape Cods best kept secrets. Short drive to stores and village, Survey plans upon request. Buyer to verify all information as it may vary


text:
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My dad passed away. He has 2 wills that I am aware of. The other party is not aware of the newer will. The newer will omits names of his children. My dad did not list them because he was never legally married to their mother nor is his name listed on their birth certificate. Also, he re-done his will because he said they did not have his best interest in mind. The old will do not list my brothers whom my dad legally adopted. Should my dad have listed them as his children on his newer will. He have acknowledged them as his children. He just refused to include them in his will.
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Bangladesh+Zim to play an Prelim Round in 2014 World T20 Along with 6 Associates
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December 2, 2013, 02:35 PM
al Furqaan
Banned for 3 months
Join Date: February 18, 2004
Location: New York City
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Even if we beat AFG/IRE 1000000 times, those IND and PAK fans wont stop saying that.
Both PAK and IND fans do that from hatred, so no need to worry who we face. We will go through inshahAllah.
Thank you for finally stating the obvious! ICC is about defending the 'elite' 8 sides despite the fact that NZ/WI/SL are no better than us. for the last 2-3 years we've just hovered under the top 8, but with the young core we have now its just a matter of fixtures before we permanently leapfrog WI or NZ in the top 8. Then we will see one or more of the established sides tusseling with the associates for entry.
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The Reelin gene (RELN) encodes a secretory glycoprotein critical for brain development and synaptic plasticity. Post-mortem studies have shown lower Reelin protein levels in the brains of patients with schizophrenia and bipolar disorder (BP) compared with controls. In a recent genome-wide association study of schizophrenia, the strongest association was found in a marker within RELN, although this association was seen only in women. In this study, we investigated whether genetic variation in RELN is associated with BP in a large family sample. We genotyped 75 tagSNPs and 6 coding SNPs in 1,188 individuals from 318 nuclear families, including 554 affected offspring. Quality control measures, transmission-disequilibrium tests (TDTs), and empirical simulations were performed in PLINK. We found a significant overtransmission of the C allele of rs362719 to BP offspring (OR = 1.47, P = 5.9 × 10–4); this withstood empirical correction for testing of multiple markers (empirical P = 0.048). In a hypothesis-driven secondary analysis, we found that the association with rs362719 was almost entirely accounted for by overtransmission of the putative risk allele to affected females (ORFemale = 1.79, P = 8.9 × 10–5 vs. ORMale = 1.12, P = 0.63). These results provide preliminary evidence that genetic variation in RELN is associated with susceptibility to BP and, in particular, to BP in females. However, our findings should be interpreted with caution until further replication and functional assays provide convergent support.
The Reelin gene (RELN) encodes an extracellular matrix protein critical in neuronal migration, cortical lamination, and overall brain development [Fatemi, 2005]. Reelin is secreted into the extracellular space, where it binds to one of two receptors (VLDL-receptor and/or the APOE receptor 2), setting off a phosphorylation cascade that, among many targets, leads to the phosphorylation of glycogen synthase kinase 3 (GSK3), a key component of the Wnt pathway [Herz and Chen, 2006]. In the adult brain, Reelin is strongly expressed in GABAergic interneurons of the hippocampus, where it has been found to play an important role in neuroplasticity and long-term potentiation, by modulating and recruiting the glutamatergic NMDA receptor to the post-synaptic cleft [Chen et al., 2005].
Goes FS, Willour VL, Zandi PP, Belmonte PL, MacKinnon DF, Mondimore FM, Schweizer B, National Institute of Mental Health Genetics Initiative Bipolar Disorder Consortium, DePaulo JR Jr, Gershon ES, McMahon FJ, Potash JB. 2010. Sex-Specific Association of the Reelin Gene With Bipolar Disorder.
Am J Med Genet Part B 153B:549–553.
The RELN gene, which spans 517.7 kb on chromosome 7q22 and contains 65 annotated exons, is a putative candidate for involvement in both schizophrenia and bipolar disorder (BP). The chromosomal region of 7q22 has been implicated in a joint meta-analysis of BP and schizophrenia linkage studies [Badner and Gershon, 2002]. Studies have found lower Reelin mRNA expression and protein levels in GABAergic neurons of patients with schizophrenia and BP [Fatemi et al., 2000; Guidotti et al., 2000; Veldic et al., 2007], which have suggested that lower levels of Reelin expression may be associated with susceptibility to both disorders. In addition, upstream of the RELN promoter sequence is a CpG island that has been observed to be hypermethylated in the post-mortem prefrontal cortex of cases with schizophrenia compared with controls [Grayson et al., 2005], which could explain the reduced expression; notably, pharmacological agents used in the treatment of schizophrenia (clozapine [Dong et al., 2008]) and BP (valproic acid [Dong et al., 2007]) have been shown to reverse this hypermethylation. We note, however, that some recent studies have failed to replicate the observation of RELN hypermethylation in schizophrenia [Tochigi et al., 2008].
Convergent support for the involvement of Reelin in psychotic disorders has also emerged from mechanistic studies in the heterozygous reeler mouse. Although the heterozygous mouse does not have marked anatomical abnormalities of the brain, more subtle behavioral abnormalities such as delayed pre-pulse inhibition (PPI) [Barr et al., 2008] and attenuated methamphetamine-induced hyper-locomotion [Matsuzaki et al., 2007] have been reported. Interestingly, PPI abnormalities have been routinely found in schizophrenia [Greenwood et al., 2007] and, to a more modest degree, in BP [Schulze et al., 2007], while methamphetamine-induced hyper-locomotion is a widely used animal model of mania.
While there have been relatively few genetic association studies of RELN, a recent pooled genome-wide association study (GWAS) of schizophrenia found replicated evidence for association with a marker (rs7341475) in intron 4 of the RELN gene [Shifman et al., 2008]. Both the initial study and the subsequent large replication analysis of 2,274 cases and 4,401 controls found this association to be specific to females (ORgenotype = 1.58, combined P = 8.8 × 10–7), raising the possibility that the association of RELN is modified by sex. However, no subsequent replications have been reported.
In addition to the post-mortem and animal studies described, increasing genetic evidence suggests that schizophrenia and BP may share some aspects of common etiology [Potash, 2006]. In this study, we test the hypothesis that common genetic variation in RELN may be associated with BP, by performing a comprehensive linkage disequilibrium (LD)-based study of RELN in a well-characterized BP sample of 1,194 individuals from 319 nuclear families.
We selected nuclear families with affected offspring from three BP family studies: the Chicago, Hopkins, National Institute of Mental Health (NIMH) Intramural Program study [McInnis et al., 2003]; the Clinical Neurogenetics study [Detera-Wadleigh and McMahon, 2006]; and the NIMH Genetics Initiative Bipolar Disorder Collaborative study [1997]. All subjects signed IRB approved informed consent forms prior to enrolling. Affected offspring (237 quads and 80 trios) were diagnosed with bipolar I disorder (N = 489), schizoaffective disorder, bipolar type (N = 26), and bipolar II disorder (N = 39) using DSM-IV or Research Diagnostic Criteria. They included 335 affected females (60.5%) and 219 affected males (39.5%). Among the 554 affected offspring, 341 (61.6%) had psychotic symptoms, defined as a lifetime history of delusions and/or hallucinations.
Using "LD-select" and Phase I data from HapMap [Carlson et al., 2004], we selected 78 tag single nucleotide polymorphisms (tagSNPs) to cover RELN (517.7 kb) and 10 kb of surrounding sequence with r2 ≥ 0.8 and MAF ≥ 0.1. Genotyping was performed on the Illumina BeadArray platform, which had assays for 75 of 78 tagSNPs, as well as for 6 additional coding SNPs. All genotyped markers were in Hardy–Weinberg equilibrium (HWE) and the average missing data rate across the experiment was 0.04%. To attempt to replicate the recent association of rs7341475 in females with schizophrenia, we also genotyped rs7341475 using an ABI 7900HT and a TaqMan assay. This marker was found to be in HWE and had a missing data rate of 0.5%.
TDT analysis was performed in PLINK [Purcell et al., 2007]. Empirical P values were derived by performing 10,000 "gene-dropping" permutations using the "–mperm" command. In a post hoc analysis, stratified TDT analyses were performed according to the sex of the affected offspring. To test the statistical significance of the difference in association by sex, we used an implementation of the TDT in STATA 9.2 with sex as a covariate [Cordell et al., 2004]. We formally tested for differences with and without the sex covariate by fitting a conditional logistic regression model that included a term for the covariate by genotype interaction. Likelihood ratio tests (LRTs) were used to test whether the model including the interaction term provided a better fit to the data than a model without the interaction term.
Power calculations using the Genetic Power Calculator [Purcell et al., 2003] showed that under an additive model and with an assumed disease prevalence of 1%, and a Bonferroni corrected α = 0.0007, our sample had >80% power to detect a risk allele of moderate effect (OR = >1.4) over the common range of disease allele frequencies (0.1–0.5).
As shown in Table I, single-marker TDT analyses of the BP phenotype revealed six markers with a nominal P < 0.05 (full results are shown in Supplementary Table I). After empirical correction for testing of multiple markers, association remained significant at rs362719 (nominal P = 5.9 × 10–4, empirically corrected P = 0.048), located 86 base pairs from exon 42 of RELN, in a region of low LD (Fig. 1). The common (C) allele was overtransmitted (194 transmitted:132 not transmitted) to affected offspring with an OR of 1.47.
Since a recent GWAS of schizophrenia found a robust association in RELN SNP rs7341475 in affected females [Shifman et al., 2008], we attempted to replicate this association. However, we found no evidence for transmission disequilibrium for rs7341475 in our main sample (P = 0.38), or in our female-stratified sample (P = 0.46). Nevertheless, given that this recently reported association with schizophrenia was specific to females, we performed a secondary TDT analysis across all of our SNPs stratified by sex. As shown in the Table and Figure, this analysis showed that the significant association of rs362719 was almost entirely accounted for by transmission to affected females (ORFemale = 1.79, P = 8.9 × 10–5 vs. ORMale = 1.12, P = 0.63). Evidence for transmission disequilibrium remained significant after empirical permutation to test for multiple markers (P = 0.0073). The difference in ORs was also found to be statistically significant in a LRT (P = 0.037) when a conditional logistic regression model incorporating sex as covariate was compared to a model without the covariate.
Finally, as the initial report of reduced RELN expression levels in BP cases were found in patients with the psychotic form of the illness, we performed an additional family-based association analysis in the 341 affected offspring with psychotic symptoms (delusions and/or hallucinations). Again, the strongest evidence of transmission distortion continued to be in affected females with the rs362719 marker, although the effect size (ORFemale = 1.59) and statistical significance (P = 0.01) were lower than for the full affection phenotype, and no result from this analysis survived empirical correction for multiple testing (Supplementary Table II).
This study provides initial evidence, from a family-based study, for association between RELN SNP rs362719 and BP in females from multiply affected pedigrees. Although candidate gene studies of RELN have been performed in schizophrenia and autism, this study represents, to our knowledge, the first focused association study of RELN in BP. Using a carefully characterized sample and a family-based design, we found overtransmission of the derived C allele in the overall sample to affected offspring (OR = 1.47), which was almost entirely accounted for by overtransmission to affected females (OR = 1.79). This finding remained significant after correction for multiple markers.
The Reelin protein is composed of a distinctive N-terminal domain followed by eight tandem repeats, each consisting of 350–390 amino acids. Each repeat comprises an extracellular growth factor (EGF)-like domain surrounded by two subrepeats. rs362719 is located 86 bp upstream of exon 42, which codes for the EGF-like domain of the fifth Reelin repeat [Royaux et al., 1997]. Interestingly, recent in vitro studies have found that both the fifth and sixth Reelin repeats are essential for binding to the two Reelin receptors, ApoER2 and VLDLR [Chameau et al., 2009]. Moreover, addition of the repeat 5–6 fragments was also sufficient to induce phosphorylation of Dab1, an "adapter" molecule responsible for triggering the Reelin intracellular signaling cascade. It is also possible that a potential risk allele is located in the intron itself, perhaps within a regulatory element with sex-specific effects.
Despite its important role in neurodevelopment and plasticity, genetic variation in RELN has only been comprehensively studied by the recent GWASs of BP and schizophrenia, along with a Scandinavian case–control study of schizophrenia [Käahler et al., 2008]. The latter study of 577 cases and 1,136 controls genotyped 71 markers in RELN and found 6 nominal associations (P values of 0.046–0.003) with schizophrenia, although the authors did not report a sex-specific analysis and it is unclear whether rs362719 was assayed. In the BP and schizophrenia GWAS results to date, there has been little support for association in RELN. However, most of these studies have used the Affymetrix platform which does not assay rs362719. As shown in Figure 1, rs362719 lies in a region of low LD that is poorly imputed; indeed, even with all genotypes of the HapMap phases I–III, the most closely linked SNP to rs362719 is insufficiently correlated (r2 = 0.44) to allow imputation with high confidence. To our knowledge, only one published GWAS of BP or schizophrenia has assayed this SNP [Need et al., 2009]. This schizophrenia case–control study found no overall association with rs362719, but did not report sex-specific analyses for this marker.
Notably, our female-specific finding with RELN parallels the results from a recent schizophrenia GWAS [Shifman et al., 2008], albeit with a different marker. Although sex-specific associations may be vulnerable to higher rates of type I error [Patsopoulos et al., 2007], our analyses were hypothesis driven and within the context of several converging lines of evidence suggesting a sex-specific effect for Reelin. For example, rat studies have provided evidence that the female hormone progesterone strongly upregulates the expression of Reelin in peripheral nerves [Roglio et al., 2008]. In addition, studies of the heterozygous reeler mouse have found significant cell loss in the cerebellum of males, with no evident effect in females [Hadj-Sahraoui et al., 1996]. The heterozygous reeler mouse was also found to have diminished expression of the oxytocin receptor [Liu et al., 2005], which is key to one of the most well characterized sexually dimorphic signaling pathways in the brain [de Vries, 2008]. While such mechanistic data are not available in humans, a meta-analysis of 12 post-mortem brain expression studies found RELN levels to be moderately, but significantly, lower in females compared with males (–1.10 change, P-value = 1.5 × 10–4), as well as lower in BP cases compared with controls (–1.11 fold change; P-value = 0.03), however, data on diagnosis-sex interaction is not available [Stanley Medical Research Institute Online Genomics Database, 2009]. We further note that there have been several prior sex-specific genetic association findings in BP including those in GPR50 [Thomson et al., 2005]. Such findings might reflect genetic correlates of well-known clinical variation in illness patterns between the sexes, such as those associated with the female reproductive cycle [Payne et al., 2007].
The strengths of our study include the rigorous characterization of subjects using the DIGS, a well validated diagnostic instrument. Our study also benefits from a family-based design that is robust to spurious findings from population stratification. This is of particular concern for markers like rs362719, which show marked allele frequency differences between populations. However, one limitation of our family-based sample is that we had suboptimal power to detect alleles of small effect (OR < 1.4). A second limitation is that, because the tagSNP selection was based on Phase I of the HapMap project, we did not cover the common variation in RELN as comprehensively as a tagging approach based on the more recent Phase II version of HapMap would have. Third, our sex-specific analyses were exploratory and require confirmation in additional samples.
Additional Supporting Information may be found in the online version of this article.
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


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Ranbir Kapoor and Anushka Sharma have reached London to shoot for their upcoming film Ae Dil Hai Mushkil. We bring to you some leaked pictures from the movie's sets.
Bollywood diva Aishwarya Rai Bachchan is also the part of Ae Dil Hai Mushkil. But the actress will reach London once she is done with the promotions of her comeback film Jazbaa.
Talking about the film Ae Dil Hai Mushkil, Anushka Sharma wrote on micro blogging site Twitter, "Sooo today we start filming #AeDilHaiMushkil in London. Butterflies attacking. Excitement rolling. Send me your love & wish me luck guys!!"
9Apps Facilitates Meeting Of 'Love At First Sight' Couple
Anushka Sharma also posted a very cute picture of Ranbir Kapoor who slept while waiting for his food. Anushka captioned it-"Please see our hardworking hero#AeKaamHaiMushkil".
Filmmaker Karan Johar also shared one picture of Ranbir Kapoor and Anushka Sharma with Ae Dil Hai Mushkil clapstick. He wrote, "You can never meet with the demands of the heart....our journey begins today...#AeDilHaiMushkil".
Click on the slider to view the on the sets pictures of Ae Dil Hai Mushkil.


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These days, most toy stores sell children's science kits that turn things like physics into a fun hands-on learning experience. But once in a while, a mad scientist comes along who's able to demonstrate the principles of physics without having to buy any equipment at all. Take the dad in this video, for example. All he has are his ordinary backyard pool and a floatable. To most people, that's just a recipe for a good time. But this dad knows how to maximize the fun through physics. He turns his pool and floatable into the the perfect lab to demonstrate test a principle called "constructive wave interference." While the phrase may sound complicated, you did see the word "wave" in there, right? And sure enough, this experiment is all about making giant waves! Here's how Wikipedia explains it: "If a crest of a wave meets a crest of another wave of the same frequency at the same point, then the magnitude of the displacement is the sum of the individual magnitudes—this is constructive interference." What does this mean? Well, basically, when two waves of the same size come together at the same time, they double in size. So get ready for waves twice as big as you've ever seen in a back yard pool. It's a science lesson his kids will never forget!
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Time and again, Ileana kept denying about hot hunks linked to her, except confirming that she got heartbreak when her love for a South hero was rejected. Later, she got charmed by Australian photographer Andrew, but never had she acknowledged it. However for the first time she came open about her new lover on a social network, albeit indirectly.
When someone asked Andrew about how girls would easily get flattered for any man, the photographer replied, "Ladies love a man who can make a decent Latte, cook a meal and do single arm push-ups". Responding on Andrew's post, it is none other our enticing hip beauty who responded in style. "Ha haha, is it any wonder why I love you?" asked Ileana, directly confirming her love for photographer Andrew, and indicating that he is good at doing all those things he said. This surely made her fans get a jolt, as she spilled beans simply.
With Ileana's confession going public, even Andrew responded, "When you said you did, I won life's lottery. I love you". Do we need any more reasons to confirm about these latest love birds? Probably not.


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Ftwalk is a high level script programming language, very similar to awk, but greatly extended to include a richer type system, object-oriented features, 300+ built-in functions, extensibility through dynamic libraries, etc., which makes it roughly comparable to languages like Perl. It does file tree searches, and was originally used to implement selective redundant copy backup stores. It can be run interactively as a calculator.
|Software Development Interpreters Testing Archiving backup Systems Administration Utilities
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Release Notes: This release adds packaging changes to use CVS, sourceforge.net, and more GNU coding standards. Porting updates have been added for Linux and UnixWare.
Release Notes: Release 1.5.2 now available. Changes include new licensing (now GPL), porting fixes (mostly Linux), and some significant language changes to make it easier to port awk scripts to Ftwalk.
A Fluent OpenStack client API for Java.
A TWiki appliance that is easy to use and lightweight.


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I've been seeing someone few months. We have never been officially dating but we spent most of our free time together. She told me that she always has an amazing time with me and thinks I am an incredible person. The last few weeks we have argued and stop talking for a day or two. We make up and spend the weekend together but by Monday she says that there is no romance or another week it's she feels awkward. She has told me she is confused about how she feels. This week she left my place and by the afternoon she told me that she feels that there is no chemistry between us. I told her that I was going to walk away from all of this and she argued that she wants me to be her friend so we can continue to talk and hang out. I find that this would be awkward and don't want this. Why would she want to continue to hang out and talk like nothing has happened? I asked her if I was a last resort and she said that she never thought that way and loves spending time with me. What does she really want?
What does she really want?
What Girls Said 1
She wants start over official again. See where it goes. Fix the mastakes she made the first time. Love you contently. tell you the truth of everything plus some. So do you? Can u handle the new and improved?00|00|0
I care greatly for her and may even be ready to say that I love her. She has told me that she thinks I am amazing and incredible and I will make someone very happy one day. I go to walk away and she fights to keep me as just a friend. She has shown some red flags but also green ones. She gets super jealous if she thinks I am online (where we met) and always throws in my face about talking to others but she does it to. I've deleted my account and she still has hers hidden. It's been 3 days since I've talked to her. Should I?
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I love you. Thats all i know
Do I know you?
What Guys Said 1
If what you say is true... seems like she's right. i see a "friends with benefits" relationship in the making though.
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The Scorpion Solar Powered, All-Terrain, Multifunction Radio Flashlight from Eton Corporation is rugged and water-resistant with its rubberized cladding. Its built-in battery can be charged from an active USB port, via its built-in solar panel or dynamo hand-crank, or using an optional AC adapter. The multifunction unit includes an LED light, a digital clock, a bottle opener, and a built-in carabiner, all of which adds to its appeal for outdoor enthusiasts. Radio reception includes AM, FM, and the National Oceanic and Atmospheric Administration (NOAA) weather band. An auxiliary input jack lets you amplify sound from an MP3 player or other device, and a headphone output lets you listen in private.
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On Oct. 14, Paulaner Bräuhaus Guangzhou opened on the third floor in Guangzhou's Taikoo Hui, becoming a new member in the world famous Paulaner Bräuhaus family.
With traditional Bavarian decoration, Paulaner Bräuhaus Guangzhou not only serves Paulaner beer, but also dishes local Bavarian cuisine such as popular pork knuckles, sausages and specialty recipes.
Brewmaster Stefan Frank is the wine maker following original recipes and Executive Chef Stefan Poguntke prepares authentic Wiener schnitzel to provide a true Munich experience.
Paulaner Bräuhaus Guangzhou will also host great events like Oktoberfest with specially brewed Festbier in autumn.
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