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The Juventus midfielder was pleased with the gritty display from the Azzurri against the Boys in Green, but warned that a completely different challenge awaits his side
"It was tough, especially the last minute when we were waiting for the result from the other match, but then it finished very well for us," Marchisio stated to UEFA.com.
The Azzurri booked their ticket for the quarterfinals following Monday's results in Group C, and the Juventus midfielder believes the crucial stage of Euro 2012 starts now.
"Now a new tournament begins for us, after an up-and-down round which was half very good and half so-so," Marchisio said.
"But we got through this group stage, which wasn't easy, with Spain, Croatia and Ireland, who even though they were already out of the tournament gave everything they could against us. So great credit to this team, who showed big character in a crucial game."
Italy will take on the winners of Group D in its quarterfinal clash.
Goal.com has a new podcast! Goal Daily Podcast is a MUST for all Soccer fans and discusses the very latest news and views. What's more when you sign up the service is FREE for the first month and you can cancel anytime.


text: One of the first complaints you experience as a beginning runner is shortness of breath. It's as though your lungs just can't keep up with your feet and your heart is pumping like crazy, trying to maintain the pace. And that is when you start thinking you just may not be cut out to be a runner. But with a little bit of coaching, you can develop your lungs and heart into running machines—and finally set your inner runner free.

subset: commoncrawl


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Model of the Week: Amy Bracco
Many high school graduates travel for leisure right after graduation. As soon as Model of the Week, Amy Bracco, graduated high school, she headed straight to Paris, Sydney and London strictly for business. Amy, a Walnut Creek, CA native who was discovered at a local modeling competition, had modeled during Summer and Winter vacations in Los Angeles and San Francisco, but her travels overseas allowed her to beef up her portfolio. She is currently based in New York City.
You may recognize her from ad campaigns like Guess? Diesel, Coach, DKNY, Tretorn, Dove, and Clinique. The model has also graced the covers of magazines and has done TV ads for Pantene, Samsung, Oil of Olay and Garnier Fructis.
Check out her beauty interview with BELLA.
To see a gallery of pictures and to read her fashion interview,
FAB: What is the most memorable show you walked in?
AB: Betsey Johnson. She is so much fun and the energy surrounding that show was fantastic. Her passion for life just oozes off of her and everything she touches is positively affected by it.
FAB: If your house was burning down and you could only save one clothing item, what would it be and why?
AB: Wow. I guess my first pair of True Religion blue jeans. They are perfectly worn in now and so soft!
FAB: What is one destination you still need a stamp for on your passport?
AB: Japan, India, Thailand, Capetown in South Africa...the list goes on forever. The more I see, the more I want to.
FAB: Who are your favorite designers?
AB: I love Diane von Furstenberg. Her dresses are easy to throw on and she knows a woman's body so well. Rebecca Taylor does amazing dresses as well. I love Free People dresses for summer. I also love Australian designers Alice McCall, Willow and Sass & Bide. I stock up every time I go back for a visit to Sydney.
FAB: What are three words that describe your personal style?
AB: Casual, comfortable, classy; the 3 C's!


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January 10th, 2017
KLG on topless 'Bachelor' siren: 'We had a word for that in high school'
A new episode of "The Bachelor" aired Monday, and Hoda Kotb and Kathie Lee Gifford have plenty of (negative) opinions on the latest shenanigans. See their reactions to one contestant who sheds her bikini top with bachelor Nick Viall. "And then he takes that home to mama and daddy," Kathie Lee comments.


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I decided to go over my forums again and make a lot of adjustments and add/remove plugins that I have collected, tried or seen recently to add to the forum and adjust moderator permissions and access and was wondering how others handle their own forums.
Below is a list of what I plan to do now that the forum has taken off and was wondering if anyone else has a better way to do these, can recommend further plugins or ways to extend on these or whether they should just be removed.
- Welcome message via conversation which links the help guide to using the forums and a greeting welcoming them
- Agree to rules
- Links, signatures and post moderation for the first three posts will be flagged as moderation if certain criteria is flagged and after that they have full access
- Starters guide (how to use the forum, permissions, features etc)
- Rules
- Premium features guide
- Specific area guides (if these areas work different to the rest of the forum
This section is something I'd probably prefer feedback on most. I currently have forum moderators for specific areas and then a few global moderators. The global moderators can hard-delete threads and the normal moderators soft delete. The global moderator basically has full access more or less to everything and the normal moderators limited. My Global Moderators can see the Administrator areas (due to the type of forum it is) and the normal Moderators have their own section. The Global ones can edit the thread starter too.
Now my questions would probably be along the lines of how do you handle your moderators, do you use the warning system or the thread system to a specific area, do you give them access to the spam cleaner and such and any add-ons that can be recommended to help them (besides Moderator Essentials, we plan to get this).
How do you handle this on your forums? At the moment I have set criteria for the spam which flags users but can be annoying going through a lot of spammers and banning them and I also use a spam email address list which helps a lot. As I mentioned above, users need three posts before they can use links and I've adjusted my spam filter to block links even if they have spaces to try and bypass it which seems to be working. One thing I noticed is a lot of bandwidth suddenly being used by these spammers, how do people handle this on their forums?
I also just noticed the 'Show Deleted' add-on by AndyB which will help with the soft deleted posts so any more that can help would be welcomed.
Sorry for the boring thread that has been asked a ton of times on various points. I have done a search and I am NOT asking how to run my forum, just looking for feedback in case I missed anything that would be useful.


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BMW 2 Series Convertible Production Set for Late 2014
An open-air version of the new 2 Series introduced earlier this month during the Detroit Auto Show will be sold in the U.S. and will reach production late this year.
BMW board member Herbert Diess confirmed the rough timeline to Ward's Auto during the Detroit Auto Show earlier this month. The company is gearing up to launch the coupe version that AutoGuide.com had the chance to drive this month in Las Vegas.
SEE ALSO: 2014 BMW M235i Coupe Review – Video
The current 1 Series will be replaced by the 2 Series, positioned as a small rear-wheel drive sport coupe under the 3 Series, which used to hold that place in the lineup. BMW;s plan was always to move the coupe and convertible models to even-numbered nameplates with the same change taking place for the new 4 Series.
Diess said the open-air 2 Series will "likely" be a soft top, hinting that the brand's top brass hasn't made a final decision on whether or not a convertible hard top is in the cards. The new 2 Series grows slightly compared to the car it replaces and the high-performance M235i is already being anointed by reviewers as a spiritual successor to the E46 M3.
[Source: Ward's Auto]
Discuss this story at our BMW 2 Series forum.


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I was running near the south side of the White House yesterday when I was nearly run over by some fat fucking woman on a Segway. For those who don't know what a Segway is, it's a transportation device used by healthy people to mock the handicapped.
Figure 1: You have legs. USE EM!
Any person without a physical disability caught on one of these goddamn things should be arrested and punished by having his legs amputated, or at least be classified as legally retarded (as should anyone who feels the need to wear a helmet while traveling at walking speed).
For those who haven't encountered them personally, there are two types of Segway douches:
1.) The Owner
This is the rare assfuck who shells out upwards of $5,000 for the privilege of pretending his legs don't work. You'll see a surprisingly large number of these motherfuckers careening around the streets of DC, barely or not at all avoiding running people over as they make their way from their Capitol Hill row house to whatever government building they're going to sit in for eight hours avoiding real work and filling with acidic suck the lives of millions of Americans. The most infuriating part about the Segway owner is the fact that my tax dollars are subsidizing his laziness in a vicious conspiratorial circle of financial waste:
Figure 2: How the government uses your money
2.) The Tourist
Here's how the typical American fatass winds up in my city on a Segway and ruins my day in ten easy steps:
- Asshole from Iowa finishes making love to his sister
- Sister/Wife (Swife) suggests "Woooo WHEE! I THANKS WE SHUUUD TAKE UH VACATION!"
- Husband and Swife pack up their four inbred children and hop in their 20 year old station wagon
- Along the way, they pick up standard white man tourist gear: neon ball cap with wide brim, extra large sunglasses, fannie pack, khaki shorts, high rise socks, and "rugged" leather hiking sandals
- The Clampetts arrive in DC, avoiding the SE quadrant of the city at all costs and arriving at the Mayflower Hotel
- The Clampetts are fat from decades of eating mayonnaise sandwiches, and are afraid their feet may explode if they walk too far. They sign up for a Segway tour.
- Ethiopian cab driver takes advantage of arcane zoning system to charge $12 dollars to take the Clampetts the 1/2 mile to downtown DC to join the tour
- The Clampetts plop down $100 per person to join 40 other lazy idiots just like themselves and roll down the sidewalk with them in unison like a platoon of overweight cyborgs, relishing in the envious looks they receive from pied-à-terre fatties and the looks of disgust from non-fatties who aren't too lazy to walk
- The eldest daughter, Susie Clampett, is losing control of her Segway near the Old Executive Office Building because she is a.) a gastropod, and b.) an inbred retard. She yells to her father "Uncle Daddy! What's wrong with this thang?!?!" as it turns violently to the right, makes a U turn, and nearly causes her to run over a nearby mulatto runner.
- Mulatto runner now has to increase pace significantly to stay ahead of the mobile death squad, because they are following his route. 2 miles later his body quits on him; vomits in front of confused/horrified children and their parents.
Oh well. At least I can take some comfort in this:
When it was launched in December 2001 the annual sales target was 40,000 units, and the company expected to sell 50,000 to 100,000 units in the first 13 months. Segway Inc's investors were optimistic. Inventor Dean Kamen predicted that the Segway "will be to the car what the car was to the horse and buggy" and John Doerr, a venture capitalist who invested in the company, predicted that Segway Inc would be the fastest company to reach $1 billion in sales. In fact only about 30,000 Segways were sold from 2001 to 2007.
Critics point to Segway Inc's silence over its financial performance as an indication that the company is still not profitable, as about $100 million was spent developing the Segway.
-from Wikipedia
Figure 3: Think about it…


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$15 For $30 Worth Of Casual Dining
Some folks do strange things when they're really hungry, like wearing pajama pants in public, believing the words of politicians, or—even worse—stopping to eat at a fast food restaurant. Why not do something you'll be proud of, like take advantage of this tasty offer from Mother's Ale House, good for $30 worth of classic pub fare for only $15?
If you're looking for a great spot to grab a bite and watch the game, check out Mother's Ale House in Wayne. They have a menu full of classic pub fare that's sure to please the pickiest eaters. Start with some Fried Pickles or an order of Mother's Soon-To-Be-Famous Chicken Wings, in your choice of seven sauces. The slow-smoked Pork Ribs fall off the bone, and Mother's Lobster Mac & Cheese is a seafood lover's dream. There are plenty of sandwiches, salads and soups too, along with over 100 big-screen TVs to watch the game on. There's even a private party room available for your next event.
Mother's Ale House & Grill offers classic pub fare and a fun atmosphere. They feature over 50 craft beers and have over 100 big-screen TVs to watch all of your favorite sporting events. They're open seven days a week for lunch, dinner, happy hour and late night.
Merchant will abide by gift certificate state laws. No cash or credit back. Each certificate must be used in one visit. Not valid on tax or gratuity. Limit 1 certificate per table per visit. Certificate cannot be used in conjunction with any other certificate, coupon, special or promotion. Dine in only; not valid for take-out or delivery.
When new offers are available from this business.


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I have had issues with my family for years and have decided enough is enough. I have relocated to a new state and I am starting my new life. I am planning on changing my name as well. The names I have chosen for first and middle names are Melanie, Rachel, and Eliana. I am leaning more towards Melanie Rachel. I have done research on my family tree and have chosen surnames from my ancestors. The surnames I am considering are York, Fox, Shapiro, Bacall, and Marlowe. I am wanting to have a hyphenated surname so need two surnames that sound best together. I have always liked the look of a hyphenated surname. Also need help deciding on the first and middle name as well. Which names do you like best from my list? I would appreciate your opinions and input. Thank you.
I am planning on changing my name and would like opinions on the names I have picked out. Can you please help?
Have an opinion?
What Guys Said 2
Wouldn't a hyphenated surname be the result of getting married, and adding your husbands surname to yours?
I personally like the name Rachel, and if you decide to keep your surname after marriage I would think that Marlowe would be a good first half. The other ones might sound awkward with another name after it.
Rachel Eliana Marlowe has a nice ring to it, doesn't it?00|00|0
Always thought Saphia/Safia is a really nice name... Also Serena and Ariana00|00|0
What Girls Said 0
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Contracts Employment Job Descriptions Meetings Public Examples Reports Rules (PDF) Salary Schedules Survey
Below is the Organization Chart of Human Resources Classified Personnel
Effective July 1st, 2015 the Personnel Commission/Human Resources classified staff are relocating across the parking lot, to the eastern-most portable, next to the Food Services department. The address and phone extensions for the affected staff will remain the same.
The following staff members will be included in this relocation:
Brandon Tietze
Executive Director, HR
Tel:(714) 999-5667
Marie Ragazzo
HR Analyst
Tel:(714) 765-7824
Melanie Thomasson
Employee Relations Analyst
Tel:(714) 999-2576
Aldaberto Hernandez
HR Analyst
Tel:(714) 999-5933
Jeff Gilbert
HR Assistant
Tel:(714) 999-3549
HR Technician
Tel:(714) 765-7826
HR Technician
Tel:(714) 999-5680
HR Technician
Tel:(714) 999-7756
Natalie Durley
HR Technician
Tel:(714) 999-7718
Main Number
Tel:(714) 999-3548
Fax Number
Tel:(714) 220-4502


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Chicken and Pecan Salad Under the Stars
Recipe by Bitsie
This is so good and simple to make. I take this to picnics under the stars at outdoor concerts here in my area. Hence the name given to this chicken salad by my family and friends. Can be made ahead which I like. Cook time is actually chill time.
Top Review by sugarpea
This is a wonderful chicken salad. I made it just as written with one change and two additions. I used yogurt cheese, Recipe #77269 rather than sour cream, added some apsparagus because I had it and it needed to be used and added a chopped apple because I liked the crunchy sweetness it added. We enjoyed it it over mixed lettuce and spinach. I think it would make a great sandwich. We'll find out tomorrow; if Dh leaves the leftovers alone tonight.
See Discussion:1 Review
Ingredients Nutrition
- 4 cups cooked chicken, diced
- 2 cups celery, diced
- 1 cup mushroom, fresh sliced
- 1⁄2 cup sweet red peppers or 1⁄2 cup green sweet pepper, chopped
- 1⁄2 cup toasted pecan halves or 1⁄2 cup pecan pieces
- 4 slices crisp cooked bacon, crumbled
- 1 (8 ounce) carton sour cream
- 1 cup mayonnaise or 1 cup salad dressing
- 2 tablespoons lemon juice
- lettuce leaf
- 3 -4 pieces pita bread, cut in halves
Directions See How It's Made
- In a large bowl, combine chicken, celery, mushrooms, red or green pepper, pecans and bacon.
- In a medium bowl, stir together sour cream, mayonnaise and lemon juice.
- Add to chicken mixture; toss to coat.
- Season to taste with salt and pepper.
- Cover; chill for 2 to 24 hours.
- Serve in lettuce-lined pita or on salad plates.


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The Demon Stick was a Memory sticks of the nezumi which told the tale of a great demon defeated by the tribe. The holder can harm Invulnerable creatures with any weapon as if it were a magic, crystal, or jade weapon. [1]
- ↑ Way of the Ratling, p. 87
|This magic or religion related article is a stub. That means that it has been started, but is incomplete. You can help by expanding this article.


text:
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After the work is complete, return to the site and rate your tradesman based on their quality of work, reliability and value for money.
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Neil gave a good and fair price for the job to be completed, the chimney repair job was completed quickly and efficiently within 2 days to a high standard, I would definitely recommend R Pillings & Sons they trustworthy and I wasn't asked for any money until the job was finished which is always an extra vote in confidence. I had a few different quotes from various builders but went with Neil in the end because I felt he was the right man for the job! Great Service would use again
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Managing your job is easier with the Rated People Homes App, download it today.


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|Message view
|« Date » · « Thread »
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|"James Strachan" <james.strac...@gmail.com>
|Re: which code to use (was: Re: Broker not delivering messages to consumer)
|Tue, 06 Jun 2006 15:24:42 GMT
On 6/6/06, massive.boisson <email@example.com> wrote: > > I am still in initial phases of development my app with AMQ. Production will > be in about 4 months. > > Existance of relativiely 'obvious' or 'critical' bugs, and their fixes > probobly means I should use latest code. Given we're always improving the software and fixing more issues and tuning things, its generally a safe rule to use the latest releases... > My questions are: > > - what is the best way to get the latest code (including patches)? I was > looking at the site, and it seems there is no usual nightly build option. > Means I should get it from SVN and compile it on my local machine? There's a link on the download page I just updated... http://activemq.org/site/download.html unfortunately it looks like the nightly snaphot builds have broken again so will try get those running again so that you can just download binaries and not have to build things yourself. But you can certainly grab the latest from SVN and build that with maven 2.0.4 or later. http://activemq.org/site/building.html > - what is your opinion, how experimental is latest code on SVN? is this to > maybe cause more pain then gain? There's little experimentation going on these days; we've mostly been focussing on bug fixing and tuning for quite a few months now. The main area of development other than minor ease of use things and bug fixes will be in the Kaha persistent store which is an optional feature (not enabled by default yet anyway). -- James ------- http://radio.weblogs.com/0112098/
|View raw message


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With First Tutors: Music you can find a Bakewell viola teacher. Viola tuition are a great way to learn a fun new hobby, acquire a new skill and gain confidence with viola. Use our site to find Bakewell viola tutors and select which matches your needs so you can begin your viola tuition in Bakewell immediately!
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If you are a viola teacher wishing to offer your viola lessons in Bakewell or anywhere else across the UK, please register with First Tutors: Music or learn about us here. Becoming a Bakewell viola teacher is a great way to improve your own knowledge through giving viola tuition while assisting someone else, all in Bakewell!


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Brunswick County has made its holiday event list, checked it twice, and predicts crowd turnout to be nice.
Brunswick County has made its holiday event list, checked it twice, and predicts crowd turnout to be nice.
The Charles Dickens Christmas Festival heralds the onset of the holiday season as it returns to Southport Friday and Saturday.
The Brunswick Arts Council is partnering up with the city of Southport and local merchants again to create a Victorian village in Franklin Square Park complete with Christmas trees, wreaths, gingerbread houses and carolers decked out in 19th century British garb.
Last year marked Dickens' 200th birthday, which was the original inspiration for the event.
Local merchants and restaurants are prepared for an increase in business the festival should deliver. "Event attendance was estimated at 2,500 people last year," Dellinger said.
For festival details, go to www.brunswickartscouncil.org
Shallotte has a full day of holiday events planned for Dec. 7, says Shannon Viera, president of Brunswick County Chamber of Commerce.
The annual Shallotte Christmas Parade will begin at 10 a.m. followed by Christmas on the River, located in Shallotte Riverside Park from 12-5 p.m. Admission to Christmas on the River is free and includes arts and crafts, live entertainment and a Brunswick stew cook-off at 4 p.m. Winners will be announced around 6 p.m. at Rourk Gardens just before the tree lighting. The tree lighting also signals the start of Shallotte Lights Up, a town-wide lighting and caroling event.
"Shallotte Lights Up highlights local businesses and promotes holiday shopping," Viera says.
Businesses that sign up, decorate, and light their spaces at 6 p.m. Dec. 7 will be included in the Shallotte Lights Up Christmas Card – a promotional ticket that holiday shoppers use when visiting local stores. Each purchase made at a participating merchant earns a sticker. Every sticker collected enters them in a grand prize drawing on Dec. 20. "It's always good to get more business," says Judith Allen Huffman, owner of J Huffman, a women's clothing and gift store on Shallotte's Main Street. "I hope this event encourages people to shop locally; it keeps things moving at home."
Following a 21-year tradition, The North Brunswick Christmas Parade and Festival will be held the second weekend in December.
The festivities kick off with a tree lighting behind Leland Town Hall on the evening of Dec. 13. The parade begins 10 a.m. Dec. 14, followed by the festival opening at noon at the Leland Town Hall Park.
John Crowder has headed the parade planning for 15 years.
"The festival definitely bolsters the economy," he says. "A lot of the vendors are local businesses that benefit by using the parade as advertising."
About 3,000 people are expected to attend.
For more information, go to www.ncchristmasfestival.com
Metro desk: 343-2389
On Twitter.com: @StarNewsOnline


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text:
If the Southeastern Conference is able to adjust a 2010 University of Alabama football schedule that includes six SEC opponents who are idle the week prior to playing the Crimson Tide, it will come as a mild surprise to Nick Saban.
VESTAVIA HILLS | If the Southeastern Conference is able to adjust a 2010 University of Alabama football schedule that includes six SEC opponents who are idle the week prior to playing the Crimson Tide, it will come as a mild surprise to Nick Saban.
The UA coach met with media prior to the Nick's Kids Golf Tournament at the Old Overton Golf Course in Vestavia Hills Thursday, and touched on topics ranging from his foundation to the UA schedule to conference expansion. Since December, the SEC has been seeking ways to reduce the number of idle-rested opponents on Alabama's schedule. UA Director of Athletics Mal Moore called for the relief during a meeting of league athletic directors roughly six months ago, as well as a league-wide scheduling mechanism to limit the number of idle-rested opponents on all SEC future schedules. The league's scheduling parameter for future schedules, a work in progress for SEC Associate Commissioner Mark Womack, will solve the issue beginning in 2012. Finding short-term relief for the Crimson Tide's 2010 schedule has been more difficult.
"I think we're hoping for the best and expecting the worst," Saban said. "I know everybody tried to do the best that they could, but those kinds of things are not simply resolved. We appreciate everybody's effort and cooperation. I'm not sure there's a lot that can be done."
Ole Miss, South Carolina, LSU, Tennessee, Mississippi State and Auburn, all on Alabama's 2010 schedule, are scheduled to be idle the prior week. The SEC has sought cooperation from within the league on the issue, but is also considering non-conference games as a means of addressing the problem in the short term.
TOURNEY FUNDS ON RISE Saban said the golf tournament benefitting the Nick's Kids Foundation continues to grow.
"Terry and I have been really excited about having the opportunity to do something to give back to the people who are in need, especially in our state," Saban said. "We're getting up in that $400,000-a-year range now as we continue to (get) great support for this event here today. A lot of the things we do, we contribute to, whether it's helping to educate young people who can't afford to go to college or giving opportunities to young people who need them."
The tournament was a Texas Scramble format, and all nine of Saban's assistant coaches were assigned to a foursome, as well as other UA staff members. There were more than 20 foursomes for the event.
APR REACTION Saban said the NCAA's recently-released APR (Academic Progress Rate) report is a validation for the football program's off-field development initiatives.
"I think it's really an indication of the kind of program we're trying to have. We work hard on personal development to try to get guys to do things right. The most significant thing guys are going to do when they come to our school is get an education, and graduate from school and develop a career off the field. We do a better and better job of that institutionally and I think the APR report is an indication of that," Saban said.
Every UA sport scored above the NCAA APR standard of 925. Programs that score below 925 are subject to sanctions.
FRESHMEN IN Saban said all but two incoming freshmen are now enrolled at the Capstone. Saban prefers incoming freshmen to enroll in summer school as quickly as possible.
"We have all guys but two in, and we had several that we had some question about, but we can only bring 25, and we'll decide later in the summer which of those guys will be able to come in," Saban said.
Defensive back Deion Belue of Deshler High and two-way athlete Blake Sims of Gainesville, Ga., are continuing academic efforts to qualify for enrollment.
EXPANSION TALK With the college football's major conferences beginning an expansion process that could radically alter the sport's landscape, Saban was asked about the look of traditional conferences and how they might change.
"It is a little crazy because there are some traditions in college football, the Southeastern Conference, the Big Ten, ACC, and I know what used to be the Southwest Conference but the Big 12 sort of took that," Saban said. "This sort of breakup that may occur is something that violates that a little bit. I think it would be great for the SEC, maybe I shouldn't say this, if we had some schools like Texas, Oklahoma, Texas A&M, those kind of schools that sort of increased our regional locale or whatever. But we have a great conference right now with a lot of good schools, a lot of great passion and tradition. I don't know where all this is headed. But I have a lot of confidence in Mike Slive that he would do a good job of keeping our conference competitive and sort of one step ahead in terms of what's on the cutting edge in college football relative to being competitive as a conference."
TIDEBITS Saban said center William Vlachos has participated in summer workouts without any physical problems. Vlachos missed spring drills while recovering from foot surgery. ... Saban said cornerback Dre Kirkpatrick had offseason shoulder surgery and is currently in rehabilitation, but believes the sophomore will be ready for fall camp in August.


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How do I look 😊😊😊?
What Guys Said 41
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you look great, turkish gal :)11|00|0
looking good00|00|0
Cute, but definitely too much makeup...00|00|0
Wow !!! You are absolutely stunning. I love how your eyes smile :)))))))))))
Just want to ask on a scale of 1-10, how much would you rate actor 'Sendhil Ramamurthy' in terms of sexiness?
You look like a nice girl... even though I know you take the D on occasion11|00|0
Awesome hair~11|00|0
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What Girls Said 12
omg adorable!!! :)11|00|0
Your hair is looong! Mine used to be pretty much the same length ages ago. But yeah, you look lovely. ^-^11|00|0
Very pretty indeed, but you've overdone the lipstick in pic 2 and possibly 3 as well.11|00|0
You look cute girl!! Way to work it.11|00|0
Cutie! :)11|00|0
Your hair is beautiful!!11|00|0
you are a beautiful young lady11|00|0
Girl you are so cute!!!11|00|0
You look cute00|00|0
You're cute11|00|0
Your face is not attractive at all. But your hair makes up for it lmfaooo00|00|0
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text:
- Description
- View Full Specifications
- Year:
- 1999
- Length:
- 57'
- Engine/Fuel Type:
- Twin / diesel
- Located In:
- Port Jefferson, NY
- Hull Material:
- Fiberglass
- 1906-2774701
- Last Listed Price:
- Sold
Twin MAN Marine D2B66LE405 610HP Diesels w/1196 hrs
3 stateroom/2 head layout. This beautiful Pilothouse MY is an original owner boat. She has always been inside stored during the winter and has been cared for by the local MAN dealer.
Click on the Full Specs button for more information.
Please contact David Boscola at 631-477-2886
Additional Specs, Equipment and Information:
Hull Shape: Modified Vee
Beam: 17 ft 2 in
Minimum Draft: 4 ft 11 in
Bridge Clearance: 14 ft 2 in
Deadrise: 10 ° at Transom
Dry Weight: 53000 lbs
Total Power: 1220 HP
Engine 1:
Engine Brand: MAN
Engine Model: D2B66LE405
Engine Type: Inboard
Engine/Fuel Type: Diesel
Engine Hours: 1196
Engine Power: 610 HP
Engine 2:
Engine Brand: MAN
Engine Model: D2B66LE405
Engine Type: Inboard
Engine/Fuel Type: Diesel
Engine Hours: 1196
Engine Power: 610 HP
Fresh Water Tanks: (226 Gallons)
Fuel Tanks: (800 Gallons)
Holding Tanks: (76 Gallons)
Number of single berths: 6
Accommodations & Layout
Forward guest stateroom has island bed, 2 large hanging lockers, 2 large opening hatches & 4 port lights. Aft to port is second guest stateroom w/over & under bunks, large hanging locker, & opening porthole. To starboard is guest head w/stall shower & VacuFlush toilet. Mid-ship is the full beam master stateroom w/large island bed, 2 large hanging lockers, 2 opening portholes, ensuite master head w/tub & VacuFlush toilet. Hallway cabinet contains a washer & dryer.
Pilothouse has full control station w/electronics, L seating to port w/table, port & starboard opening doors, and stairway to flybridge.
Cockpit door leads to the Salon which has L lounge to port w/table & 2 stools, entertainment center to stbd w/TV, stereo, SatTV, wetbar w/Corian countertop & icemaker.
Galley is to port. Galley features full size Frigidare refrigerator, Whirlpool microwve, AEG 4 burner stovetop, Creda stove/oven (never used), Broan trash compactor, wine cooler, wood flooring, Corian countertops, 2 SS sinks. Opposite galley is large U shaped dinette to starboard.
Electronics & Navigation
- Furuno 48mi Radar
- Northstar 962 GPS/Plotter
- RayChart 611T
- Raymarine 650 Auto Pilot
- Standard Horizon Quest X VHF Radio
- Jabsco Searchlight
- Raymarine ST60 Depthfinder
- 5" Ritchie Compass
- Jensen Stero
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- Raymarine ST60 Depthfinder
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- ICOM M-412 VHF Radio
- 5" Ritchie Compass
- Pioneer Stereo
Electrical System
DC & AC systems, 50A/220V shore power inlet w/Glendinning Cablemaster, Westerbeke 20kw Generator w/soundshield (1769hrs), 2-24V Promariner battery chargers (80A & 40A), Trace Engineering Power Conversion Center.
Deck & Hull
Bimini top, radar arch, flybridge cushion covers, flybridge wetbar w/refrigerator, low profile davit, swim platform w/2 walk thru transom doors, through bow plow anchor w/Lewmar windlass (chain & rope), 4 SS fender baskets, bow thruster.
Engines & Mechanical
4 Zone heat/air conditioning, dual Racor 1000 fuel filters, oil change system w/clutches, airseps, block heaters, dripless stuffing boxes, Perko raw water strainers, trim tabs w/indicators, 6 auto bilge pumps, Glendinning engine synchronizer, Hynautic engine controls, ZF 2:1 transmissions, automatic halon fire protection.
The Company offers the details of this vessel in good faith but cannot guarantee or warrant the accuracy of this information nor warrant the condition of the vessel. A buyer should instruct his agents, or his surveyors, to investigate such details as the buyer desires validated. This vessel is offered subject to prior sale, price change, or withdrawal without notice.
Other Boats from Boscola Yacht Sales
3788 Command Bridge Motoryacht
Eastern Long Island, NY, United States


text:
PHILADELPHIA — Danny Briere scored the winning goal 4:36 into overtime to lead the Philadelphia Flyers to a 4-3 win over the New Jersey Devils on Sunday to open the Eastern Conference semifinals.
Briere had his second chance at the winner count minutes after his earlier attempt was overturned on review because he kicked it into the net. He also scored in the second period.
He wasted no time making it up for the OT missed opportunity. He fired a slapper past Martin Brodeur for his seventh goal of the playoffs. Brodeur was screened in front by Philadelphia forward James van Riemsdyk.
The Flyers took the series lead in their first game in a week after eliminating Pittsburgh in six games. The Devils played their third consecutive overtime game after defeating Florida in Games 6 and 7 to win the first-round series.
In Glendale, Ariz., Shane Doan, Radim Vrbata and Antoine Vermette each had a goal and an assist, and Phoenix avoided its usual overtime theatrics, beating Nashville to take a 2-0 lead in the Western Conference semifinal series.
Martin Hanzal and Taylor Pyatt also scored for the Coyotes. Ryan Suter, Patric Hornqvist and Andrei Kostitsyn scored for the Predators.
Phoenix scored three times on 19 second-period shots. The Coyotes built a two-goal lead early in the second period. Nashville twice cut it to one only to see Phoenix quickly respond.
The Coyotes did not go into overtime for only the second time in eight playoff games.
The best-of-seven series shifts to Nashville for Game 3 on Wednesday night.


text:
If it winds up disappearing, meaning, men won't exist, could women not only get alond and run the world but, also would they "turn" lesbian? (would lesbianism actually exist if only women existed)?
Most Helpful Guy
Who cares what happens if men would disappear, those lesbians can go fuck themselves for all that I care. Also there is already an comic book about this weird situation.


text:
Talia Studio Photographer
ms2014Model Female San Diego, California, US
My MM URL: http://www.modelmayhem.com/melanieilene
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About MeI enjoy modeling for photos as a hobby. I am interested in doing trade for photos and learning more. I would like to do lifestyle shoots or fitness shoots especially. I am a fitness trainer & surfer girl, experienced brand ambassador & promo model.
** Looking to do a beach shoot this month (December) bikini/ fitness wear
Have you worked with ms2014? Add Credits for ms2014! >>
Talia Studio Photographer
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text:
To reference this posting:
I have a ton of email going out of the exchange server on a daily basis out of one of my clients (a few thousand a day at least), and 2 domains that email are being sent to get this error...when I investigated further, the 2 domains have antispam software hosted by the same company!
I called said company (who's name will go un-named here), and their support dept. (one employee) could see email from my clients company hitting his spam server, and being let through, however, I get the employee at my client showing me emails from the exchange server that say it keeps trying and eventually fails to send (this is over a course of a day or two that it takes to fail).
My clients server is not blacklisted, greylisted, etc. with Barracuda (Barracuda's Intent Block List.)So, is there something in my DNS settings that are causing this? (either on the mail servers NIC, or the external, internal DNS, etc.?)
I have flushed the DNS on the mail server, and the problem still exists.
Any suggestions on why this is happening and/or how to troubleshoot further?
25 Replies
Dec 19, 2011 at 5:54 UTC
could they be checking spf records? if they are and you don't have one set up it may cause an issue
here is some more info
help you make an spf record
test spf record
Dec 19, 2011 at 6:19 UTC
Wow! nice! We don't have an SPF record of our own! Funny, cause we actually use SPF record checking on the emails that come in to our mail server...
man, Molan, if that's it, I'm gunna cry...it's always the simplest stuff isn't it?! I'll give this a whirl and post back.
Dec 20, 2011 at 8:34 UTC
Is there a way to check for sure if that's it? Using the receivers domain, or their support rep. etc.? I'd like to do it behind the scenes if I could.
Dec 20, 2011 at 9:26 UTC
only way I can think of is to contact them and see if you can find someone who knows what they are talking about who can tell you if they check or not.
Dec 20, 2011 at 2:16 UTC
That's the key ;)
Talking to someone that knows what they're talking about that doesn't want to talk down to me...
Dec 20, 2011 at 2:22 UTC
could they be checking spf records? if they are and you don't have one set up it may cause an issue
here is some more info
/ www.microsoft.com/ mscorp/ safety/ technologies/ senderid/ default.mspx
help you make an spf record
/ community.spiceworks.com/ topic/ 185506-exchange-2010-451-4-4-0-dns-query-failed
test spf record
The help you make an spf record link above seems to be a link to this topic, do you have another page you were thinking about?
Dec 20, 2011 at 2:28 UTC
whoops, here is the correct link
Dec 20, 2011 at 2:47 UTC
Cool! Whaddya think of the "scope" section? I mean, I want to minimize the amount of spam through spoofing and such, yet I want to ensure that my clients email reach their destination.
Dec 20, 2011 at 2:53 UTC
I set mine to both, just to be safe
Dec 21, 2011 at 6:26 UTC
Ok, I tried that, then followed the instructions on the GFI website to implement it (go to the domain under the DNS section in the Roles, and right click the domain, and choose "other new records", then choose txt, then enter in info there...however, after doing that and clicking on "done", I do a spf verify check with various websites, and they say I do not have an SPF.
Is there a period of time a guy needs to wait for this to take affect?
Dec 21, 2011 at 7:25 UTC
yes, depending on how long the TTL record is for your domain, usually you have to wait at least 2 hours before you will see the change, If it isn't working by the next day then I would start looking further
Dec 23, 2011 at 4:52 UTC
I have been able to telnet to one of the antispam hosts (caisnet.com) for a domain (hoeng.com) that we have not been able to reach (turns out the host caisnet, is hosting 3 domains out of 3 that we're having a problem with).
I was able to connect via telnet, and set the "mail from", however, when trying to set the "rcpt to" mail.hoeng.com, I got the following error:
553 Requested action not taken: mailbox name not allowed
What might cause this? Is their firewall turned up too high? An SPF issue? IPv6? Etc.?
Dec 28, 2011 at 4:18 UTC
my bad, the 553 error above seems to have been generated because I used the backspace key when entering in the rcpt to email address.
I was able to telnet to the mail.caisnet.com mail server, and it found the "rcpt to:" email address, and sent a test message with no problems.
I wonder how I can find out if it's a problem on their end or ours?
Jan 4, 2012 at 3:25 UTC
So, it ended up being that my clients server had 2 IP addresses pointing to it's reverse dns ptr entry...the ISP seemed to have missed this :(
I'm the new guy and I caught this! Lol-ing in the streets!
Well, makes the bossman know why he pays me the "big money" :P ;)
This has resolved the issue...seems the barracuda antispam software didn't like that we had 2 reverse dns IP addresses!
Jan 10, 2012 at 10:11 UTC
I was just about to say that !
Jan 11, 2012 at 2:50 UTC
Thank you for all your help in the pm'ing Jono, wouldn't have figured it out 100% without you mang! :)
Jan 11, 2012 at 6:22 UTC
Thank you for all your help in the pm'ing Jono, wouldn't have figured it out 100% without you mang! :)
That's awesome, been watching this one, can everyone share what was the solution in detail if you can please?
Jan 11, 2012 at 6:34 UTC
In gory 3D full HD detail?
If you're lookin' fur the 2D kinda detail, u'll be lookin' at the first post on page 2 by me ;)
If ur lookin' for the gory detail, dunno that I have time for that ;)
Here's a rehash:
Do a reverse DNS lookup of a guys mail servers external IP address, confirm that it results in the same IP that is pointing to the mail server and that there's only 1. We found we had 2 IPs pointing to our clients mail server...turns out the ISP is responsible to make sure this is setup correctly...
I suppose at the end of the day, its the server admins job to police the ISP :(
Jan 11, 2012 at 6:37 UTC
Thank you Lance, and I will be waiting.....looking forward (HA get it....DNS forward lookup........) for the 3D version.
Jan 11, 2012 at 6:39 UTC
Oh, and I suppose the moral of the story is, if you're dealing with the steel jaws of barracuda antispam (ahherm, tight like a nun), then there's ur sign (ala redneck comedy tour).
Jan 11, 2012 at 6:43 UTC
I can't stand any product by barracuda.....have never had any luck with that product and it's supposed to be for SBS......HA.......it's a joke and a pain in the ass to maintain......but that's just my opinion.
Jan 11, 2012 at 6:44 UTC
Nice :P
Plug fur ur avatar...
Annoying orange rulz!
Jan 11, 2012 at 6:47 UTC
Nice :P
Plug fur ur avatar...
Annoying orange rulz!
It makes me laugh, dumb as he may be, I need a laugh from time to time, that's why I chose it, and yes........hey apple.....KNIFE!
This discussion has been inactive for over a year.
You may get a better answer to your question by starting a new discussion.


text:
Silver Warriors' defense tightens up
Niskayuna girls' soccer coach Bryce Colby has one of the most dangerous scorers in Section II in Meghan Doyle.
But he knows it will be his defense that will play a large role in determining how far his team will go in the postseason.
Thursday's 1-0 win over Suburban Council North Division rival Shaker gave Colby many reasons to feel good about his team's chances in the upcoming Class AA tournament. But the work of his three defenders brought special praise.
"They played very well, and they play so well as a unit," Colby said of outside defenders Sophia Constantine and Olivia Golden, and central defender Stephanie Tate. "It was nice to win a game with a shutout, especially a 1-0 game."
"We were pretty solid in the back today," said Tate. "We play really well together, and we have a stopper that comes back to help."
"It's good to know we can win a game 1-0," said Doyle who just missed on a couple of good chances. "In sectionals, the games get closer. It's always more of a fight."
"The second time through the schedule is so tough," said Colby. "Everyone is gearing up for sectionals. They beat us, 3-1, early in the season. Now we come back and beat them."
The Lady Warriors got a goal from sophomore Marika Contompasis 12 minutes into the game, and it looked like more were coming as Niskayuna's players on the right flank, particularly Contompasis and Kelly Hartledge, frequently got enough time and space to send balls to the back post.
"It was almost like a goal was coming," Colby said.
But the game's only goal came from the middle of the field, as Hannah Munro played a perfect through ball to space in front of Contompasis, who lifted a shot over Shaker goalkeeper Julia
Colby was quick to point out the role of another player in the scoring play.
"I know Hannah got the assist for the great pass, and Marika gets credit for the goal, but the player who created that goal was Kelly Hartledge," said Colby, whose team went to 12-2-0 with the win, "She ran wide, and pulled a defender with her. That opened space for Hannah to play that ball for Marika to run on to. There was no cover from her [Hartledge's] defender.
"If she moves in towards the middle, now you're dealing with two defenders and space is tight.
"She's not going to get an assist, but Kelly made that goal with her run."
The latest goal from Contompasis was also a good sign, according to Colby.
"We needed to find that player who could play with Meghan up front," Colby said. "Marika's really been a key.
"It's still a work in progress. Marika's still learning where Meghan likes the ball to be played, whether Meghan is going to shoot or lay the ball off.
"When you have one very good player up top, that's great. When you have two, it creates that many more problems for the defense."
"They have two dynamic offensive weapons, so you've got to make sure on defense," said Shaker coach Tara O'Keefe, whose team is looking to lock up one of the top four seeds for the "AA" playoffs. "Our defense and midfield played great. We've got to find a way to score goals."
Niskayuna finishes the season with games against Shenendehowa and Burnt Hills, two other teams with strong postseason histories.
"Those are going to be important games. They'll help us get ready for sectionals," Tate said.
"It prepares you, because those games are kind of like sectionals," said Doyle.


text:
15 Books to Empower Tween Girls
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text:
So, i have a cisco integrated router 1811. I'm in the process of setting up my NAC, My question is thus: Do I have to use the cisco ACS program, Or can I use any RADIUS server?
the cisco ACS seems a bit overkill/overpriced for what I need.
Any suggestions.
P.S. I need somthing for windoz.
8 Replies
Oct 25, 2008 at 6:04 UTC
IT Journey, LLC is an IT service provider.
Ii'm not completely sure, but when I looked at the Cisco NAC solutions it was going to run me about $110/device. That is for regular SMB pricing, not government or non-profit.
With the release of Windows 2008 Server and Windows XP Service Pack 3 Microsoft NAP may be a much more cost effective solution for you. Once you have a 2008 Windows CAL, you can run NAP on Windows XP SP3 and up machines without any additional licensing. If you are a mixed environment, then that would eliminate that, but you only mentioned Windows as a requirement.
From what I understand, the Cisco solution wants cisco devices throughout your network (I think they want all you switches to be Cisco Layer 2 switches...might be able to work with Layer 3 too). Microsoft doesn't really care about the network since they are securing the network a little differently than NAC.
Call a local vendor for each and get a demo of each.
Best of luck.
Oct 26, 2008 at 1:26 UTC
Thanks craig,
Yes, the cisco NAC/ACS solution is looking less desirable, and no I dont have excluively cisco gear. And I also have a mixed workstation environment, so NAP is probably out.
I may be overcomplicating the issue though, Perhaps I need to look closer at simply using AAA on my cisco with a Radius server. Honestly dont know enough about it, but Basically I'm trying to determine what is going to be the best way to initiate a logon to access the network. I'm looking at various methods, and the cisco is the "mother ship" so to speak, it makes sense to me? to integrate it with a radius server to handle the users/policies/etc.
Sometimes I feel cisco complicates things, making it more complex, and yes, more expensive, than it need to be. If I had to do it over I would have gone with a open source linux solution such as m0n0wall.
Thank for the input.
Oct 26, 2008 at 9:00 UTC
I am using Cisco ACS at my work. It has been a while since I have looked at the config, but we use ACS to authenticate against their Active Directory accounts using the LEAP protocol. My version of ACS will also let you create internal accounts on the ACS server. The solution works pretty good for us.
I believe Craig M is correct on the Layer2/3 switches. I know that our Cisco Aironet Access Points are programmed as trunked devices which will allows them to handle multiple vlans.
I know that our corporate office is now pushing Aruba Networks. I don't recall the reasons for switching, but you may want to check them out as one of your options.
Good Luck!
Oct 26, 2008 at 11:13 UTC
IT Journey, LLC is an IT service provider.
What features/goals are you trying to acomplish by implementing a NAC/NAP solution.
Oct 26, 2008 at 11:55 UTC
Essentially, I started out wanting to initiate a basic login for network access. Looking at my setup, which basically consists of a Cisco 1811 router, a couple of switches, and a couple of wireless access points, It's a pretty basic setup, all the same vlan, same subnet, pretty small network.
given I already had the cisco in place, I started looking at NAC, and it's capabilities. but I'm not too concerned at this point with the extra security options it provides.
Basically, i want to create a user login, that would redirect anyone trying to access the network, to login, via a login page, both wired and wireless users. Foremost, I would like to be able to set privileges for users, as to how much time/throughput they can use, per a set time, such as half hour per day, 50Mb per day. etc. That is the prime purpose for this. Just want to have some simle control over who gets on the network, and how much time they spend on it. We're a small school, and I want to have different access priv, for students, staff, facutly, guests, etc.
For all practical purposes a captive portal. The more options for growth the better.
I thought perhaps using cisco NAC, would be handy l, given the added advantages that it would provide, such as ensuring users conform to security policies, and autherization/accounting of equipment, but it's really not necc.
Somthing fairly simple to setup would be nice as well, I have a pretty good handle on basic networking, and have some cisco setup experience, and I usually manage to noodle my way through things, given enough time and access to the right informaiton, But I'm in new territory with this one, and all the options and information are a bit challenging to weed through and decide whats best.
Oct 27, 2008 at 3:02 UTC
IT Journey, LLC is an IT service provider.
If that is all you are trying to do, they I think NAC might be a overkill for you. NAC is good if you need to check the compliance of a computer before it gains access to your network. If can check for applications on the PC, updates, etc and make a determination based on its findings.
I don't think NAC and simple go together. The wrong change to a NAC policy could block ALL users from your network until you remove the NAC appliance.
Have you considered using and Access Controll List through your router and layer 2/3 switches? Looks to see if you can create ACL's on your switches and or router. If you can you may be able to have a rule that says if a system isn't in your ACL it is moved to the DMZ VLAN.
Oct 28, 2008 at 7:14 UTC
Thanks Craig,
I appreciate all the insights you've given, I've started to get things into perspective, which is not what I had jumping into this. currently I'm looking at using the auth-proxy command, and using it to authenticate with a radius server via aaa(maybe just using "local" for now until I know it works.) Thats at least a strip down, user login. In the meantime, I'm also looking at Suscriber Edge Services Managment(SESM) which I beleive is EOL, not certain what they've replaced it with. Anyway, cost is a factor, so we'll see. And I simply may not need all the bells and wistles.
Thanks again for all your insights.
Oct 29, 2008 at 9:12 UTC
IT Journey, LLC is an IT service provider.
Glad to help! Let me know if you have anymore questions.
This discussion has been inactive for over a year.
You may get a better answer to your question by starting a new discussion.


text:
You are here
Predictors of HbA1c over 4 years in people with type 2 diabetes starting insulin therapies: The CREDIT study
Diabetes Research and Clinical Practice, Volume 108, Issue 3, June 2015, Pages 432 - 440
- We identified factors predictive of HbA1c in people with T2DM starting insulin.
- Multivariable backward regression analysis selected variables associated with HbA1c.
- HbA1c over 4 years was mainly determined by the HbA1c before starting therapy.
- At 4 years, current insulin dose was the characteristic most strongly associated with concurrent HbA1c.
To identify factors associated with glucose control, as measured by HbA1c over 4 years, in people with type 2 diabetes starting insulin therapy.
CREDIT, an observational cohort study, collected data semi-annually over 4 years, on people with type 2 diabetes starting any insulin, in 311 centres in 12 countries; 2803 people had data on HbA1c during follow-up. Multivariable backward regression analysis selected characteristics associated with glycaemic control from a limited number of candidate variables.
Before starting insulin therapy, HbA1c was 9.3% (78 mmol/mol) and decreased to 7.6% (60 mmol/mol) after 1 year, and changed little after that. Insulin dose increased from 0.21 U/kg to 0.36 U/kg at 1 year, and then by 0.10 U/kg over the next 3 years. Body weight increased by 2.0 kg in the first year and increased little thereafter. Poorer glycaemic control over the 4 years was mainly determined by the HbA1c before starting therapy, after accounting for the other statistically significant associated variables in multivariable analysis: higher BMI, younger age, longer diabetes duration, more glucose-lowering drugs, using basal insulin alone, higher insulin dose and female sex. At 4 years, a higher current insulin dose was the characteristic most strongly associated with a higher concurrent HbA1c.
HbA1c at the start of insulin therapy was the characteristic most predictive of later HbA1c, after accounting for other variables associated with HbA1c. This may provide some justification for earlier insulin introduction to improve glucose control to target.
Keywords: Glycaemic control, Insulin therapy, Observational, Predictors, Type 2 diabetes.
1. Introduction
Blood glucose control is well recognised as a factor associated with microvascular complications in people with type 2 diabetes, and there is some evidence that it may slow the progression of cardiovascular diseases [1] and [2]. People with type 2 diabetes can often maintain adequate glycaemic control with appropriate lifestyle and oral glucose-lowering agents, but timely introduction of insulin therapy is indicated when glycaemic control is no longer maintained
Clinical trials have provided invaluable information about glycaemic control following therapy by differing insulin therapies. However, the people in clinical trials are highly selected according to the trial protocol, advised by the more motivated clinicians who agree to participate in trials, while participants are closely monitored in line with a trial protocol. There is less published information about the outcomes of insulin therapy in current clinical practice, and it is often only very short term
The Cardiovascular Risk Evaluation in people with Type 2 Diabetes on Insulin Therapy (CREDIT) study was designed in 2006
2. Subjects, materials and methods
2.1. Study design and participants
The CREDIT study design and selection of the people with type 2 diabetes have been reported previously
The study was approved by recruiting centre ethics committees, and informed written consent was obtained from each participant. The study was conducted according to the principles of the Declaration of Helsinki.
The principal outcome measure for this report is the average 1–4 year HbA1c, the average at years 1, 2, 3 and 4 after starting insulin; the HbA1c data used for the 1 year time point was the blood sample with a date closest to 1 year, within the time window 9–18 months after inclusion in the study; similar windows were used for the 2, 3 and 4-year HbA1c values. The average of the available yearly values was then used.
The secondary outcome measure is the HbA1c at year 4, at the end of the study, after 4 years of insulin therapy.
The main variables studied at the start of insulin therapy, as predictors of the two HbA1c outcome measures, were: sex, age, physical activity (recorded as some physical activity or none), smoking status (currently smokes or stopped <1 year; never smoked or stopped ≥1 year), family history of premature cardiovascular disease, micro- or macrovascular disease, other comorbidities, body mass index (BMI), duration of diabetes, HbA1c (normalised according to local laboratory values), number of oral glucose-lowering drugs, diagnosis of high blood pressure, number of blood pressure-lowering drugs, insulin regimen (basal alone, basal and short acting, short acting alone, premix insulin alone, other), total dose of insulin. At the end of 4 years the following additional variables were included as potential explanatory factors for HbA1c at 4 years: micro- and/or macrovascular disease or other comorbidities during follow-up; number of oral glucose-lowering drugs, insulin regimen and total insulin dose at 4 years; change in weight over 4 years; and symptomatic hypoglycaemia in the 6 months prior to the 4-year evaluation.
2.2. Statistical analyses
SAS statistical programme version 9.2 (Cary, NC, USA) was used for all analyses.
The characteristics of participants are described by percentages and by medians (quartile 1, quartile 4), geometric means and percentiles. Those with and without the two HbA1c outcome measures were compared by chi-square and Student t-tests. The percentage (95% confidence interval [CI]) achieving an HbA1c target of 7.0% at each year is shown graphically.
Both HbA1c outcome measures were loge transformed for statistical analysis, as they were right-skewed. The functional form of the continuous predictive variables was determined in linear models adjusted for region (six regions – Eastern Europe: Croatia, Ukraine and Russia; Southern Europe: Italy, Portugal, Spain; France; Northern Europe: United Kingdom, Finland, Germany; Japan; Canada) and for random centre effects (to allow for physician characteristics), by comparing the Akaike Information Criterion for models with the predictive variables in linear, loge and restricted cubic spline forms; all continuous variables (excepting change in weight) were loge transformed.
Univariate analyses of variables predicting the two HbA1c outcome measures used linear models, adjusted for region, as a fixed factor and recruiting centres as random effects. For the multivariable models, variables were selected by a backwards procedure, limited to effects significant at the conventional 0.05 level. For the HbA1c outcome measure at 4 years, an additional multivariable model included variables already selected at starting insulin, along with those measured at 4 years listed above, using a similar backwards selection procedure.
Predictors of the two HbA1c outcome measures above the 7.0% units HbA1c target were studied using univariate and multivariable mixed effects logistic regression models and backwards variable selection methods, similar to those above.
3. Results
3.1. Baseline characteristics of people followed for glycaemic control
Of the 3060 people with type 2 diabetes who were started on insulin therapy and included in the CREDIT study, 2803 had HbA1c levels recorded at and after entry (principal outcome: average 1–4 year HbA1c), of whom 2212 had HbA1c at year 4 (secondary outcome) (Supplementary Fig. S1). The people with the principal HbA1c outcome available had similar baseline characteristics to those who were not followed, except for small but statistically significant differences: more physically active, fewer smoked, more micro- or macro-vascular disease, and more high blood pressure; for the secondary HbA1c outcome measure, those studied were more often women, more physically active, fewer smoked, more family history of premature CVD, more microvascular disease, fewer comorbidities, and more treated with short-acting insulin (23% vs. 18%). The people studied were distributed across 12 countries (Supplementary Table S1), with Russia and Japan recruiting the largest numbers of people.
The characteristics of the populations with the principal and secondary HbA1c outcomes were very similar (
3.2. Characteristics over the 4 years after starting insulin therapy
The principal HbA1c outcome measure had a skewed distribution, with a geometric mean of 7.6% (60 mmol/mol), an upper quartile of 8.2% (66 mmol/mol), and 4.4% of people had an HbA1c >10.0% (86 mmol/mol) (Supplementary Fig. S2). After 1 year, HbA1c was 7.6% (60 mmol/mol) and was fairly constant thereafter, being 7.5% (58 mmol/mol) at year 4
The insulin dose increased from 0.21 U/kg (geometric mean) at starting insulin to 0.36, 0.40, 0.43, and 0.46 U/kg at years 1–4, respectively
3.3. Characteristics associated with the average 1–4 year HbA1c, the principal outcome measure
The baseline characteristics associated with a higher HbA1c outcome (Table 2 and Table 3) were: absence of other comorbidities (other than micro- or macrovascular complications, neither of which showed an association), more glucose-lowering drugs, a younger age, a higher BMI and a higher baseline HbA1c (all P < 0.0001); other variables associated with a higher HbA1c outcome were female sex, a family history of premature CVD, the insulin regimen (in particular basal insulin alone and premix insulin alone) and a longer duration of diabetes (all P < 0.01).
Geometric means (95% CI)
Univariate regression coefficients (SE)a and b for continuous variables associated with the principal outcome: average 1–4 year HbA1c and the secondary outcome: HbA1c at year 4, according to continuous characteristics at baseline and 4 years or during follow-up (adjusted for region and centre). The CREDIT study.
The multivariable analysis predicting higher average 1–4-year HbA1c, after a backwards selection of baseline characteristics, included eight predictors (
Multivariable linear and logistic regression coefficients (SE)a and b and odds ratios (95% confidence intervals) of variables at the start of insulin therapy associated with the principal outcome: average 1–4 year HbA1c after backwards selection of variables. The CREDIT study.
3.4. Characteristics associated with HbA1c at year 4, the secondary outcome measure
The baseline characteristics associated with a higher HbA1c at year 4 (Table 2 and Table 3) were: younger age, higher BMI and higher baseline HbA1c (all P < 0.0001); fewer non-vascular comorbidities and more glucose-lowering drugs (both P < 0.005). Year 4 characteristics associated with a higher HbA1c were a higher insulin dose, a greater increase in weight, the insulin regimen (in particular basal and short-acting insulin) (all P < 0.0001); microvascular disease and fewer comorbidities during the follow-up, more glucose-lowering drugs, and lack of hypoglycaemia (all P < 0.02).
After backwards selection of variables, and accounting for all other variables included as predictors in the multivariable analysis, baseline HbA1c was again the strongest predictor of HbA1c at year 4, followed by age (both P < 0.0001), then BMI diabetes duration and other glucose-lowering drugs, in order of significance (
Multivariable linear regression coefficients (SE)a and b of variables associated with the secondary outcome: HbA1c at year 4, after backwards selection of variables. The CREDIT study.
4. Discussion
In this study of people with type 2 diabetes starting insulin therapy in routine clinical practice, there was a marked improvement in glycaemic control at 1 year, which remained stable over the remaining 3 years of the study. However, at 4 years after starting insulin therapy, only 35% of the participants had an HbA1c below the general glycaemic target of 7.0% (53 mmol/mol), with 13% having an HbA1c ≥9.0% (75 mmol/mol). The main baseline characteristics associated with poorer glycaemic control over the 4 years were higher values of baseline HbA1c, age, BMI, duration of diabetes, number of other glucose-lowering drugs, insulin regimen (specifically basal or premix insulins vs. multiple injection regimens), and finally a higher insulin dose and female sex. For glycaemic control at the end of the 4 years, a higher concomitant insulin dose was the most predictive factor, with more glucose-lowering drugs, weight gain, lack of hypoglycaemia and new microvascular disease over the follow-up also associated with poorer control; baseline HbA1c and age remained predictive.
While at first sight it might seem clinically sensible that in the years after starting insulin therapy, a higher baseline HbA1c should be a co-predictor of HbA1c, along with BMI and the starting insulin dose, these variables were retained in multivariable analysis, so it cannot simply be that they are co-associated with later poor control due to investigators starting insulin later in the more obese, and then at higher doses, in conjunction with more oral agents. Similarly, it is tempting to attribute both high baseline HbA1c and duration of diabetes to a relative deficiency of endogenous insulin secretion; again these characteristics were both retained on multivariable analysis, suggesting that there may not be a single underlying unmeasured explanatory factor for predicting poorer blood glucose control. The independent association of BMI with later HbA1c could reflect a reluctance of clinicians to titrate the insulin dose in the more obese (although a higher concomitant insulin dose at the end of the study was an independent explanatory factor), or perhaps it is simply a marker of difficulty in harnessing self-motivation to improve measures of health status.
The associations of insulin regimen with glucose control over the 4 years, but not at the end of the study, need a more complex explanation. It might be expected that basal insulin alone and premix insulin would be selected for those with earlier and easier to treat blood glucose control, and thus that attained HbA1c might be lower. However, for the CREDIT study, we have already shown that the HbA1c at start of insulin therapy was not a factor associated with the choice between basal insulin and insulin regimens other than premix
Hypoglycaemia might a priori be expected to be a factor explanatory for HbA1c. Clinicians appear to expect lower HbA1c to be associated with more hypoglycaemia, contrary to the findings of the ACCORD study for either intensive or standard therapy
Other publications have addressed this issue in randomised controlled trials of insulin regimens [11], [12], and [13], in retrospective studies from electronic prescriber databases [14], [15], and [16] and in observational studies with features in common with our own [7], [17], and [18]. Randomised clinical trials however, are generally restricted to their planned comparison, and are often of short duration. The 4-T study did suggest that insulin regimen had an effect on achieved glucose control at 1 year, with those on basal insulin having worse glucose control but a better hypoglycaemia experience than those on premix or mealtime insulins alone
A previous report from the CREDIT study compared insulin regimens using a propensity score of baseline characteristics to try to overcome the probable confounding factors in the allocation of specific insulin regimens
Our study has its limitations. While the participating physicians were chosen to represent those prescribing insulin in a given country
With regard to the strengths of this study, it was prospective and longitudinal with findings over a 4-year follow-up–much longer than in many other reports. The results were generally consistent from year 1. The physicians were free to choose the insulin regimen and its dose when initiating insulin therapy; as there were no study recommendations on either, it is expected that physicians would have followed normal practice, both when starting insulin and with any changes during follow-up. This differs from the prospective observational studies discussed above, which were limited to specific insulin analogues, and of shorter duration [7], [17], and [18]. Our data are those collected and recorded in routine practice, while the large number of participants and participating physicians provide a wide range of clinical practices from the developed world. Accordingly each of the study variables would have a wide range, thus enhancing the chance of showing variables with a statistically significant association (or not) with glycaemic control. However, the large sample size may also mean that small effects that are clinically insignificant, and perhaps clinically undetectable, may be statistically significant. This is the case for weight gain at the end of the study, where a 1 kg weight gain was associated with only a 0.003% unit (0.03 mmol/mol) increase in HbA1c that was statistically significantly in multivariable analysis.
The principal characteristics for glycaemic control after starting insulin therapy thus appear to be a lower starting HbA1c, a shorter duration of diabetes, a lower number of oral glucose-lowering drugs, and a lower insulin dose. Together, these variables seem to point to an advantage in beginning insulin earlier. Some studies have addressed this point directly, and while the advantages of very early use of insulin over oral agents can be disputed, these studies do not suggest much in the way of detriment either [20] and [21]. Using the CORE Diabetes Model, Goodall et al.
In conclusion, the glycaemic control of these people with type 2 diabetes starting on insulin therapy, improved markedly by the end of the first year, and this level was maintained over the three subsequent years. However, the major determinant of success was a low baseline HbA1c, supported by lower BMI, higher age, lower starting insulin dose, and a shorter duration of diabetes. At the 4-year follow-up the predictive characteristics were similar, but concurrent low insulin dose was highly predictive, as well as a lower number of oral glucose-lowering drugs. Given the impact of HbA1c at starting insulin therapy, and also the duration of diabetes, it would appear that the timing of starting insulin therapy may be crucial in the longer-term maintenance of good glycaemic control.
Conflict of interest
B.B. has served on advisory bureaus for AstraZeneca, Boehringer Ingelheim, Bristol-Myers Squibb, Eli Lilly, Novo Nordisk and Sanofi. F.C.G. is a consultant to Sanofi. N.F. has received research grants and served as consultant to Eli Lilly, Medtronic, Novo Nordisk, Pfizer, and Sanofi and has served on speaker bureaus for Novo Nordisk and Sanofi. M.V. and V.P. are employees of Sanofi. P.D.H, either personally or through institutions with which he is associated, receives funding for research, advisory, and educational activities from most insulin and other glucose-lowering medication manufacturers, including Sanofi, Novo Nordisk, and Eli Lilly.
Authors contribution
B.B., N.F., V.P. and P.D.H. contributed to study design, study conduct/data collection, data analysis, and writing. F.C.G. and M.V. contributed to data analysis and writing. B.B. is the guarantor of this work and, as such, had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. All authors have approved the final article. These results were presented orally at the IDF World Diabetes Congress, Melbourne, Australia, December 2013 and as a poster at the French Speaking Society for Diabetes, Paris, France, March 2014.
The CREDIT study was designed by Sanofi together with a study advisory board. Data collection and analysis were funded by Sanofi; interpretation of the data was by the authors, who wrote the article and made the decision to submit for publication. Editorial support was provided by Tom Claus, PhD, of PPSI (a PAREXEL company), funded by Sanofi.
Appendix A. Supplementary data
The following are the supplementary data to this article:
- [1] UK Prospective Diabetes Study (UKPDS) Group. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet. 1998;352(9131):837-853
- [2] R.R. Holman, S.K. Paul, M.A. Bethel, D.R. Matthews, H.A. Neil. 10-year follow-up of intensive glucose control in type 2 diabetes. N Engl J Med. 2008;359(15):1577-1589 Crossref
- [3] S.E. Inzucchi, R.M. Bergenstal, J.B. Buse, M. Diamant, E. Ferrannini, M. Nauck, et al. Management of hyperglycemia in type 2 diabetes: a patient-centered approach: position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetes Care. 2012;35(6):1364-1379 Crossref
- [4] R.P. Hayes, J.T. Fitzgerald, S.J. Jacober. Primary care physician beliefs about insulin initiation in patients with type 2 diabetes. Int J Clin Pract. 2008;62(6):860-868 Crossref
- [5] T. Kunt, F.J. Snoek. Barriers to insulin initiation and intensification and how to overcome them. Int J Clin Pract Suppl. 2009;164:6-10 Crossref
- [6] M. Peyrot, R.R. Rubin, K. Khunti. Addressing barriers to initiation of insulin in patients with type 2 diabetes. Prim Care Diabetes. 2010;4(Suppl 1):S11-S18 Crossref
- [7] P.D. Home, C. Shen, M.I. Hasan, Z.A. Latif, J.W. Chen, G.G. Gonzalez. Predictive and explanatory factors of change in HbA1c in a 24-week observational study of 66,726 people with type 2 diabetes starting insulin analogs. Diabetes Care. 2014;37(5):1237-1245 Crossref
- [8] N. Freemantle, B. Balkau, N. Danchin, E. Wang, M. Marre, G. Vespasiani, et al. Factors influencing initial choice of insulin therapy in a large international non-interventional study of people with type 2 diabetes. Diabetes Obes Metab. 2012;14(10):901-909 Crossref
- [9] P.D. Home, M.-P. Dain, N. Freemantle, R. Kawamori, M. Pfohl, V. Pilorget, et al. Four-year evolution of insulin regimens, glycaemic control, hypoglycaemia and body weight after starting insulin therapy in type 2 diabetes across three continents. Diabetologia. 2013;56(Suppl 1):S410
- [10] M.E. Miller, D.E. Bonds, H.C. Gerstein, E.R. Seaquist, R.M. Bergenstal, J. Calles-Escandon, et al., ACCORD Investigators. The effects of baseline characteristics, glycaemia treatment approach, and glycated haemoglobin concentration on the risk of severe hypoglycaemia: post hoc epidemiological analysis of the ACCORD study. BMJ. 2010;340:b5444 Crossref
- [11] R.R. Holman, K.I. Thorne, A.J. Farmer, M.J. Davies, J.F. Keenan, S. Paul, et al., 4-T Study Group. Addition of biphasic, prandial, or basal insulin to oral therapy in type 2 diabetes. N Engl J Med. 2007;357(17):1716-1730 Crossref
- [12] R.R. Holman, A.J. Farmer, M.J. Davies, J.C. Levy, J.L. Darbyshire, J.F. Keenan, et al., 4-T Study Group. Three-year efficacy of complex insulin regimens in type 2 diabetes. N Engl J Med. 2009;361(128):1736-1747 Crossref
- [13] M.C. Riddle, A. Vlajnic, R. Zhou, J. Rosenstock. Baseline HbA1c predicts attainment of 7.0% HbA1c target with structured titration of insulin glargine in type 2 diabetes: a patient-level analysis of 12 studies. Diabetes Obes Metab. 2013;15(9):819-825 Crossref
- [14] B. Curtis, M.J. Lage. Glycemic control among patients with type 2 diabetes who initiate basal insulin: a retrospective cohort study. J Med Econ. 2014;17(1):21-31 Crossref
- [15] G.A. Nichols, T.M. Kimes, J.B. Harp, T.D. Kou, K.G. Brodovicz. Glycemic response and attainment of A1C goals following newly initiated insulin therapy for type 2 diabetes. Diabetes Care. 2012;35(3):495-497 Crossref
- [16] N. Wu, M. Aagren, L. Boulanger, M. Friedman, K. Wilkey. Assessing achievement and maintenance of glycemic control by patients initiating basal insulin. Curr Med Res Opin. 2012;28(10):1647-1656 Crossref
- [17] K. Khunti, S. Caputo, T. Damci, G.J. Dzida, Q. Ji, M. Kaiser, et al., SOLVE Study Group. The safety and efficacy of adding once-daily insulin detemir to oral hypoglycaemic agents in patients with type 2 diabetes in a clinical practice setting in 10 countries. Diabetes Obes Metab. 2012;14(12):1129-1136
- [18] P. Valensi, J. Shaban, M. Benroubi, R. Kawamori, V. Borzì, S. Shah, et al., IMPROVE Study Expert Panel. Predictors of achieving HbA(1c) <7% and no hypoglycaemia 6 months after initiation of biphasic insulin aspart 30 in patients with type 2 diabetes in the IMPROVE study. Curr Med Res Opin. 2013;29(6):601-609 Crossref
- [19] N. Freemantle, B. Balkau, P.D. Home. A propensity score matched comparison of different insulin regimens 1 year after beginning insulin in people with type 2 diabetes. Diabetes Obes Metab. 2013;15(12):1120-1127 Crossref
- [20] M. Hanefeld, P. Bramlage. Insulin use early in the course of type 2 diabetes mellitus: the ORIGIN trial. Curr Diab Rep. 2013;13(3):342-349 Crossref
- [21] D.R. Owens. Clinical evidence for the earlier initiation of insulin therapy in type 2 diabetes. Diabetes Technol Ther. 2013;15(9):776-785 Crossref
- [22] G. Goodall, E.M. Sarpong, C. Hayes, W.J. Valentine. The consequences of delaying insulin initiation in UK type 2 diabetes patients failing oral hyperglycaemic agents: a modelling study. BMC Endocr Disord. 2009;9:19 Crossref
- [23] I. Raz, M.C. Riddle, J. Rosenstock, J.B. Buse, S.E. Inzucchi, P.D. Home, et al. Personalized management of hyperglycemia in type 2 diabetes: reflections from a Diabetes Care Editors' Expert Forum. Diabetes Care. 2013;36(6):1779-1788 Crossref
a INSERM Centre for Research in Epidemiology and Population Health (CESP), U1018, 16 Avenue Paul Vaillant Couturier, 94807 Villejuif Cedex, France
b University Paris-Sud, URMS 1018, Villejuif, France
c AtlanStat, Rezé, France
d University College London, UK
e Sanofi, Paris, France
f Newcastle University, Newcastle upon Tyne, UK
⁎ Corresponding author. Tel.: +33 1 45 59 51 61; fax: +33 1 47 26 94 54.
Article information
DOI: 10.1016/j.diabres.2015.02.034
© 2015 Published by Elsevier B.V.


text:
Here's a more realistic version of Apple's Siri ad with Scorsese
0. phoneArena posted on 02 Aug 2012, 09:23
Apple recently scored Martin Scorsese to its list of celebrities doing ads for the iPhone, and in a nutshell it painted a pretty rosy picture of Siri helping the famous director…
This is a discussion for a news. To read the whole news, click here
40. PhoneArenaUser (Posts: 5498; Member since: 05 Aug 2011)
I know, thats why I wrote that. :D
22. Aeires (unregistered)
Cut some slack, that comment was not trolling in any manner. Just because a lot of previous comments were off doesn't mean everything should be slammed.
37. MISTER_H (banned) (Posts: 97; Member since: 08 Jul 2012)
38. MISTER_H (banned) (Posts: 97; Member since: 08 Jul 2012)
iamcc bro that was wrong. He was only stating on
his use of siri. Nothing he was Trolling.
27. iami67 (Posts: 321; Member since: 18 Oct 2011)
Thats the point Taco unless you are using siri for very simple things then siri is useless. You can not do what the comercials claim. And what your describing I have been able to do on blackberries for over 10 yrs. So why is siri so great. Ever hear of vlingo siri was a complete rip off of it but its ok apple did it.
35. gallitoking (Posts: 4721; Member since: 17 May 2011)
so i will sue burger King for not giving me the whopper like in the commercial... wait.. is called marketing...
39. taco50 (banned) (Posts: 5506; Member since: 08 Oct 2009)
Siri is light years ahead of Vlingo and Siri works great for certain things. It's not perfect, but way better than anything else out.
36. MISTER_H (banned) (Posts: 97; Member since: 08 Jul 2012)
Why the thumbs down and red.... He wasn't
28. RapidCat (Posts: 351; Member since: 12 Jun 2012)
i would love to see another ad
41. Windsponge (Posts: 92; Member since: 01 Nov 2009)
I have not had that kind of problems with Siri. Google works about same for me. I am deleting this site out of my phone it is a joke the way this site is now. Use to be a very good place to get info but now people dog stuff for no reason just to make them selves feel better about their choice. Only thing I will say is this buy what ever junk you want. Let others choose their junk with out doting them. Be human for God's sake.


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Fish Springs Coyote Hunting
Jan 5, 2008 7:35:11 PM PST
Hey all, does anyone know how the coyote hunting is around the fish springs or vernon area. I have hunted rabbits out there for years but never seen very many yotes. Any info would be helpfull.
Be safe and shoot straight
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Fish Springs Coyote Hunting
Jan 28, 2008 12:11:53 AM PST
Originally Posted by jsmith76:
Hey all, does anyone know how the coyote hunting is around
the fish springs or vernon area. I have hunted rabbits out
there for years but never seen very many yotes. Any info
would be helpfull.
Be safe and shoot straight
I hunt out near Vernon a lot. I was just out there this past
weekend, way too windy to do any calling the day I went out.
Erickson Pass Road has some good areas to call in dogs, but
I think they get a lot of pressure. Watch out for that State
Park enforcement officer, he hangs out near the top of the
Pony Express Trail a lot. He'll bust you if you aren't far
enough off the dirt roads when you shoot. Fish Springs has
a lot of hunting restrictions within the refuge. I think you
can only hunt waterfowl out there. Outside the refuge is a
different story. I think it is almost better to head out
towards Nevada. In the time it takes me to get to Vernon
from Salt Lake, I could make it out to Wells where the
coyotes are much easier to call. Overall, you hear a lot of
gun shots out near Vernon, so you have to do some extra
work to get to places where coyotes aren't being scared off.
The western edge of skull valley is probably a little more
productive. I also heard that there are some good spots
down near Fillmore. My suggestion is to drive around, do
some siren calls or howls to locate coyotes. Listen to where
they howl, wait 20 minutes, then take a stand in the area
where you heard the dog. Hope this helps. Let me know if
you have any luck.
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