text:
MyTopOff now offers high quality, custom silk screen printing on any color MyTopOff opener. This is perfect for your business of any kind, restaurant, bar, liquor store, construction business, insurance or real estate, etc. We also receive requests for fund raisers, bike rallies, beer fests, 5,10K running events, weddings, or even birthdays. Use your imagination! Everyone would love to see your logo on a MyTopOff.com opener. The best part is people cherish the gift and will keep it and show it off for years to come. You can give it knowing the MyTopOff.com opener is heavy duty, dishwasher safe and has a full lifetime warranty.
- Tired of the same old cups, caps, and pens?
- Better way to get your company noticed.
- People show this product to family and friends.
- Make your company logo show up at the next tailgating event,
BBQ, Birthday or Christmas party.
- Great client appreciation gift.
- Most orders deliver in two weeks.


text:
National Account Manager- (Foodservice- Leading Customer)- Branded & O/L FMCG Business
- Recruiter
- PT Executive
- Location
- Home-Based
- Salary
- £40,000 - £45,000 + Bonus, Car & Benefits
- Posted
- 04 May 2017
- Closes
- 04 Jun 2017
- Ref
- Function
- National Accounts, Sales
- Business Sector
- Food & Drink
- Hours
- Full Time
- Contract Type
- Permanent
As one of UK's fastest growing Branded Food & Drink Businesses, our client has an impressive track record of success and an exceptionally bright future. They have an impressive track record of growth and and Pioneering Product/Brand Innovation. Their strategic goal is to succeed in the "elusive tightrope" of driving both Volume and Value within their core offering that will see their market dominance increase considerably. As a result, the "key" differentiators are the respective "People/Executives" in the Business; and this is where you could make the difference.
As the National Account Manager you will take full P&L accountability for a massive Foodservice Customer alongside the development other OOH Customers. For 2017 fiscal year this equates to a sizeable piece of the overall sales/profit of the business, hence the role is a highly challenging one. You will also act as the Business Lead in an effort to take the category and customer to new levels of growth performance. Having close involvement with range management and merchandising, you will also feel the stretch of your intellectual capabilities as you find new ways of understanding your customer and end consumer.
- Win & Managing New Business
- Direct customer contact across all relevant functions.
- Negotiate annual Joint Business Plans (JBPs)
- Drive distribution of existing and new products.
- Manage product mix to maximise margin.
- Negotiate all elements of pricing, terms and promotions within Business guidelines.
- Deliver price increases.
- Pre- and post-evaluate promotional activity.
- Ensure that activity supports central brand direction where applicable
- Exercise Trade Spend control and process adherence
- Manage effective communication of Brand plans to the Customer Base
Whilst you will be fully supported by the Sales Director to whom you report; the emphasis will very much be on you to show how you can deliver and grow the Business. The category in which the role operates brings both challenges of leading NPD and Category initiatives requirements and also a real "tough trading" environment where strength of character is key. The Business offers successful employees a clear structured career path which they can follow across the several divisions they operate.
The ideal candidate will have gained strong experience in Retailer Brand or Branded Foodservice National Accounts within the FMCG Industry, additionally the client is also willing to consider dynamic Junior candidates currently working directly at the Jnr NAM level. Financial Acumen and Strong Negotiations skills are a must, as this role will test the toughest of characters.

subset: commoncrawl


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Frozen Anna & Elsa Tops £2 @ Asda George
I would LOVE to know how much Disney have made from those lovely Frozen sisters Anna and Elsa. The merchandise is EVERYWHERE yet it is somehow hard to get hold of unless you are will to pay £££. Asda George have reduced two Disney Frozen tops from £4 to just £2, and they are really adorable.
- Click here for the white Anna & Elsa Frozen Girls' Top from Asda George*
- And here for the sisters pink top*
These Disney Frozen tops from Asda George feature Anna and Elsa on each of them. Both tops are made from 100% cotton which means they are absolutely fine to machine wash and can be tumbled dried on a low setting. That's if you can get this off of your little ones back.
The white top features the words Let It Go and some lyrics along with a motif of our fave sisters Anna & Elsa. The pink is glittery and reads "sisters forever".
The only sizes left in both colours 9-12 months, 1-1.5 years and 1.5 -2 years. All of the bigger sizes have sold out unfortunately.
You can collect these Disney Frozen Anna & Elsa Frozen tops from your local Asda store or pay £2.95 for delivery.
TOPICS: Disney Deals Kids Clothing


text:
Stories of Music and Art History Part 1
N9: Stories of Music and History Part I
See S1 and G2 for more stories of art and artists.
See S1 and G2 for more stories of art and artists.
The Children's Book of Art
by Agnes Conway (1909)
This wonderful book provides an in depth look at masterpieces that will appeal to children, told in a way young hearts can comprehend.
How to Enjoy Pictures
by Ruth Head (1914)
This book would make a nice readaloud to an elementary aged child who is interested in learning more about art.
How to Enjoy Pictures
by Mabel Emery (1898)
How to Show Pictures to Children
by Estelle Hurll (1914)
How to Study Pictures
by Charles Caffin (1906)
A Guide to Pictures for Beginners and Students
by Charles Caffin (1918)
Picture Studies
by Alice Florer (1917)
105 paintings were selected for children to study. A very brief description is given for each one.
Pictures That Every Child Should Know
by Mary Bacon (1908)
Here are 48 masterpieces to introduce to your child. Learn many fascinating incidents from the lives of the artists who painted them along with some points of appreciation.
Christmas in Art
by Frederick Keppel (1909)
The text may be above your elementary aged children, but it may be enjoyable to them to compare the Nativity as it was painted in various nations in the 15th and 16th centuries. Details are given that you could talk about as you show the paintings. I suggest searching for color images online.
Famous Italian Pictures and Their Stories
by Haberly-Robertson (1912)
First, a very brief sketch is given of the artist followed by a discussion of some of their most important works.
Famous Paintings Selected from the World's Great Galleries, V1
by G.K. Chesterton (1913)
The text most likely won't appeal to young students, but I think they may enjoy looking at the full page art reproductions selected from galleries around the world.
Famous Paintings Selected from the World's Great Galleries, V2
by G. K. Chesterton (1913)
The Old Masters
by Lorgues-Lapouge (192-)
This volume is loaded with color reproductions from the Byzantine, Gothic, Renaissance and Baroque era. The text will be above a Middle Schooler's interest, but they may enjoy looking at the paintings after they have some background in art appreciation.
An Outline History of Painting for Young People
by Clara Erskine Waters
The print is small, but the text is simple to understand. A Middle Schooler with a special interest in art may enjoy this as a readaloud, but it will more likely appeal to a High Schooler who is interested in a basic introduction to art history.
History of Painting by Haldane Macfall
Great Pictures as Moral Teachers
by Henry Jackson (1910)
Good introduction of the value of art. Probably of more value to you as a parent than directly to your children.
The Colour-Prints of Japan
by Edward Strange (1906)
For the serious student of art. This goes into quite extensive detail into the background of Japanese art.
The World's Painters and their Pictures
by Deristhe Hoyt (1898)
Although this was written to appeal to young readers, I don't expect it to appeal to a child younger than high school age. Students will receive a sweep of art history from the ancient Egyptians to modern times.
Famous Painters and Paintings
by Julia Shedd (1876)
Brief sketches of a number of painters is provided along with one principle work of each one. For serious students of art.
Music in Art
by Luna Ennis (1903)
For your serious, mature students of art appreciation, here is a look at music represented in art.
Love in Art
by Mary Knight Potter (1898)
For your more serious and mature students of art. Take a look at love in sculpture and paintings among the ancient Greeks, in myth, in biblical times and throughout the ages.
Saints in Art
by Clara Waters (1899)
An introduction not only to the stories and legends of the Saints, but the use of religious symbolism as well.
A Handbook of Legendary and Mythological Art A Handbook of Christian Symbols and Stories of the Saints
by Clara Erskine Waters
These are pretty intense books for a student, but as a parent, if you take the symbols one at a time and introduce them, it will unlock a lot of mystery in the artwork you and your child may be enjoying.
A Manual of Oil Painting
by John Collier
A discussion of oil painting techniques for your serious art student. Not for beginners.
How to Study Architecture
by Charles Caffin (1919)
How to Judge Architecture
by Russell Sturgis (1903)
Turrets, Towers and Temples
by Esther Singleton
The great buildings of the world as described by famous writers
The Secrets of a Great Cathedral
by Henry Spence-Jones
An Outline History of Architecture for Beginners
by Clara Erskine Waters
Gothic Architecture
by Edith Browne
Norman Architecture
by Edith Browne


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Not sure if one even exists... But if there does please tell me!! I am looking for a foundation that is water proof and will not come off in the rain or if I rub my face, And will not leave residue dust on my dark clothes when it touches them. Hopefully at the same time, it is easily washed off with makeup wipes? I also want something that comes in very light colors cause many foundations do not have one that is light enough for my porcelain skin. I would like it not to peel and at the same time to control my grease. I have a combo of oily and dry skin. Maybe it could be somewhat breathable and I could sweat in it? Maybe some sunscreen in it? Oh and one more thing, I would love it if it would have good coverage. Nothing I have found will take care of those pesky creases. In my dream world, it would hardly feel like I even put anything on but make my skin lookin baby doll and flawless, and this wonderful combo would all be contained in a college-budget-friendly price range. I know this is ridiculous. But what is the closest you have found to what I'm talking about? Any ideas anyone?
Most Helpful Girl
I have this one.
I don't think it's officially waterproof, but when I wash my hands after putting it on my face (I use clean fingers to apply makeup), I HAVE to use soap. Otherwise it won't come off. I also have very light skin and I think the lightest shade matches my skin tone pretty well. And once it dries completely, I haven't experienced any stains on my clothes (however I'd still be very careful, honestly I don't think there are any foundations that will NOT stain your clothes if you're not careful). Really good coverage. A little goes a long way. If you put on too much, it'll start to look cakey. I think it hits most of the things you're looking for. I don't think there are any foundations in the world that hit all of those points, though. If you're having trouble with your over all skin health, I think you should focus more on getting proper skin cleansing products, rather than makeup that fits your very specific skin issues.11|00|0
It seems like they have now upgraded it to a guaranteed 24 hour coverage. And the shade I use has a fitting name, "Porcelain" :)
Oh perfect! Yeah that is my skin tone too!


text:
Score surface of the steak, making diamond shapes 1/2 inch deep. In a large resealable plastic bag, combine the remaining ingredients; add the steak. Seal the bag and turn to coat; refrigerate at least 2 hours, turning occasionally. Drain and discard marinade. Grill steak, covered, over medium heat for 6-8 minutes on each side or until meat reaches desired doneness. To serve, thinly slice across the grain.
By Robin from Washington, IA
Add your voice! Click below to comment. ThriftyFun is powered by your wisdom!


text:
Sauerborn's working method
1 Finding of structure
In Sauerborn's working method "greater importance is attached to color than to structural or formal problems" as the artist writes herself. Color becomes in its extreme and light intensive reduction the carrier of the essential action of the picture. In order to articulate itself "without falling into vain monochromatic tautologies", color requires organization by structure. In the process of putting greater weight onto color, the methods of combination and of regular and systematic variation with the intention of gaining the structural frame of the picture, have priority over the use of an individual structure which is always basically new in the beginning. The method used maybe called a regressive method which is followed by a progressive phase of construction. That means that after reexamining the fund of permanently multiplying structural sketches some will be taken out as familiar ones, and the law of their connexion will be formulated explicitly. In a progressive phase the construction of a discrete sequence of constellations will follow into which the underlying law of the pictures develops and materializes. Thus the sketch K0 e. g. is analysed in the regressive phase together with a series of similarly projected sketches and is subsequently constructed in a regular way by rotating the axis "a" about a fixed point "A" by 45 degrees each in the mathematically positive sense. The result of this technique is a sequence of nine discrete constellations K1 – K9 the last of which is identical with the first constellation. That part of compository work which consists in the finding of structure is largely rendered independent and is objectified.
2 Distribution of color
The distribution of color, too, is subsequently objectified and subdued to a general rule. To this end, the individual structure fields are placed together in various classes and assigned two-figure numbers. Accordingly, there are for constellation K9 three different classes of planimetrical fields that are defined by the first number: 1x, 2y, 3z depending on whether they are fields belonging to the ground (1 x) or to the figure; and here again they are differentiated according to circular (2y) and stripe elements (3z). This classification is made however only for the sake of analytical transparency of the demonstration, for Sauerborn's intentions are exactly focused on a neutralization of the differentiation of figure and ground. In our particular instance (cf. illustration K9) there are eight structural fields divided into three classes: (11,12,13), (21,22,23), (31,32). For compository reasons intended by Sauerborn, there can be made partial identifications in color of course only of non-neighboring fields without destroying the structure of the whole. Thus the following fields may be identified for example: 11 = 23, 12 = 31, 13 = 32. That means, the number of the possible different colors is reduced from eight to five. According to the program of precise exploration of all the modifications the interdependence of color through the variative compository technique is submitted to, a diagram is set up which regulates the possible distribution of nine (1 to 9) shades of color within the series of nine constellations being developed systematically from one basic situation (cf. diagram).
3 Artistic control
It still remains to be ascertained in which points of this methodical development of the pictorial action the objectivity of rules is – corresponding to its merely instrumental character – subordinated to and replaced by artistic control. For it is clearly expressed in Sauerborn's statements that artistic control is always granted priority, that any kind of methodics can only serve as a means, a means to explore as exactly and completely as possible the perspective plane, but which is not yet an end in itself, composition itself.
The spontaneity of artistic control is realized in six points of the pictorial genesis: 1. in the set-up of the fund of structural sketches, 2. in the effective selection of the structure-giving law; 3. in the chromatic identification of the structural fields which is achieved in only one possible way; 4. in the concrete selection of the underlying color chart; 5. in the process of painting, in the course of which the previously established scheme of color distribution may be modified by the concrete situation of colors; 6. in the acceptance or the rejection of a result. Thus everything is subdued to the primacy of artistic control: "Systematic representation … is a corrective of spontaneous innovation or vice versa" (Sauerborn).
first published: catalogue /exhibition "Aen Sauerborn, paintings, sculpture" 1973, Kunstverein Unna, pp. 38-42
Translation: Blandina Carl /Kempten


text:
Sweat is your body's way of letting you cool off during a workout and slide home on your belly afterward. Get a running start with this Groupon.
Choose Between Two Options
- $45 for a four-week Zumba class (a $140 value)
- $79 for a six-week Zumba class (a $210 value)
Zumba classes meet five days a week as exercisers learn fast-paced moves set to music that features Latin rhythms. See the class schedule.
Divine Body
Divine Body emphasizes an absolutely judgment-free zone as it invites exercisers to participate in fitness classes no matter their age or ability. A staff of encouraging instructors teaches classes that focus on aspects of yoga, tai chi, Pilates, cardio, and three levels of Zumba that cater to older adults or those seeking targeted body sculpting. Divine Body's facilities also offer childcare and showers.


text:
Legislation passed by the Alabama Legislature in 2013 and 2014 calls for the state to
be divided into regions and for community-led, regional organizations to coordinate the
health care of Medicaid patients in each region, with networks ultimately
bearing the risks of contracting with the state of Alabama to provide that
Click here for information on the
Integrated Provider System program
Governor Robert Bentley announces federal approval of Alabama's 1115
Waiver application -
Click here
Click here for meeting materials from
recent Provider Forums
Regional Care Organization
Overview of Medicaid RCOs -
RCO Membership Matrix - Draft List of
eligibility groups to be included in RCOs - 1/28/16
RCO Service Matrix - Draft
List of services to be covered by RCOs - 1/28/16
Click here to join the Agency's Email list for Medicaid updates!
Click here to email your questions about RCOs
Provider Enrollment Contacts for Probationary Regional Care
Organizations - Updated 10/24/16
List of Administrative Contacts for Probationary Regional Care
Organizations - Updated
List of Organizations
Certified as
Probationary Regional Care Organizations by Region -
Updated 11/3/15
Frequently Asked Questions about the Health Home program (includes
information on Letters of Intent) -
Fact Sheet: Letters of Intent and Core Specialists
- 3/9/15
Probationary RCOs Operating Health Home Programs
- 3/8/16
Frequently Asked Questions about RCOs
- 10/18/16 - Click on a question in the table of contents to jump
directly to the response.
District Map - Map based on Rule 560-X-37-.07 -
Updated 1/26/16
Legislation - Passed by the Alabama Legislature on May 7,
2013 - Codified
law is found at Ala. Code §§ 22-6-150 et seq.
Amendment to 2013 state law regarding Regional
Care Organizations - Signed into law by Governor Robert Bentley on April
10, 2014
RCO Timeline
- Outline of key dates for RCO implementation
RCO Timeline
- Outline of key dates for RCO implementation
Key Links
2015 Health Homes RFP - Released
12/29/14 - includes
Bidders' Library, amendments and Questions and Answers
Announcement of Intent to Contract
- Released 2/13/15
Section 1115 Demonstration Waiver
Official Waiver Approval Documents -
Approval Letter and Special Terms and Conditions - 2/9/16
RCO-Related Administrative Code Rules
- Final Rules - Chapter 62 - Updated
Administrative Code Rules
RCO-Related Meetings and
Materials -
Includes log
in information for Wednesday Webinars on Patient 1st and Health Home
RCO Communications
Guidelines and Resources -
Communications resources, guidelines, sample documents and other
Apply to Collaborate as an
Individual or Organization -
information about filing a periodic report
RCO Quality Assurance Committee
QA Committee as required by Act
RCO Region Demographics - Health Home
population by county and RCO region - Updated 1/6/15
NOTE: The updated Estimated Health Home
Populations by County and RCO Region include only those recipients in
each county that would be eligible for Health Home Services. The numbers
reported are the monthly totals of current Health Home recipients as of
November 2014. The previous numbers reported were higher because
it included all RCO populations, and not just those that would qualify
for Health Home services. The current numbers are more accurate.
Criteria for the Health Home Population are recipients with two chronic
conditions, one chronic condition and the risk of developing another, a
serious mental health condition with at least one of the following
diagnoses: mental health condition, substance use disorder, asthma,
diabetes, heart disease, BMI over 25, transplants with a look back of
Medicaid claims for five (5) years, cardiovascular disease, chronic
obstructive pulmonary disease (COPD), cancer, HIV with a look back of
Medicaid claims data 18 months but the basis for identification is
medications, sickle cell anemia, and/or Hepatitis C.
Disclaimer: Information and/or
approvals provided by the Medicaid Agency should not be construed as legal
advice. Pursuant to recent legislation codified at Ala. Code 22-6-150 et
seq. and rules promulgated pursuant thereto (the "RCO laws"), the Medicaid
Agency has been charged with overseeing the implementation of a new
integrated and coordinated health care delivery system intended to provide
benefits and services to Medicaid beneficiaries. By its review and/or
approval of applications and other documents submitted by persons and
organizations pursuant to the RCO laws, the Medicaid Agency is not providing
legal or tax advice to such persons and organizations but rather is
monitoring compliance with express provisions of the RCO laws. Any approval
or consent on the part of the Medicaid Agency or statement made in
connection therewith should not be construed as an approval or opinion as to
compliance with other laws. All persons and organizations submitting
applications and other documents to the Medicaid Agency should seek
independent legal, tax and other advice as they deem necessary.


text:
- Premium Raccoon Fur
- Fur is long, lush and silky
- Authentic Lambskin Leather exterior and ties
- Quilted Nylon interior for added warmth and comfort
- Designed to be worn with ear flaps down, up, or at back of head
- Front brim is secured by 2 snap buttons
- Brand: frr
- Made in Canada
Hat Size Guide
Shipping & Returns
Related Information
About Trapper Hats
About Raccoon Fur
Variations in this product family:
Write a Review
From: Hershey PA
Excellent quality and very comfortable. My size was between medium and large went with the large and fit perfectly. The straps are long enough to tie properly.
From: Jackson,Wy. USA
I have a gifted ushanka from Russia in mink,very warm, and comfortable. Opted for the Raccoon from you folks in medium and a little tight, but a hat stretcher gave me enough room to sit perfectly. The fur opened itself in a few days without brushing. Good product, as it was advertised it came to me the same way. I will order again.
From: New Jersey
Pleasantly pleased with this purchase even though I ordered it while I was hammered
From: Toronto, Ontario
I did order a different hat before this one and I must say that these sizes are SMALL fitting. Order one size up from the size chart. I found the hat to be pricey, however, you get what you pay for. Quality was great, shipping, efficient. Definitely would order again!
From: NE Ohio
Beautiful Fur: My size is between a L and XL. I got the L and after a little stretching it fits perfectly. I have a sheared beaver hat also and love them both.
From: New England
I must have gotten a dud. The fur looked like what I'd imagine my hair would look like if I stuck my finger in a light socket. (Think angry porcupine). It would not mat down or hold any semblance of form. It, quite frankly, looked about at stupid as anything I've ever seen. I returned it, and I'm guessing since all I'm seeing are 5 star reviews, this one will never make the cut.
From: Brooklyn, N.Y.
I received the hat in less than a week. The hat was beautiful, the fur and the leather was nice. Cannot wait to purchase another hat from Fur World. Wish that more of the hats would come in the 2X size.
From: Ottawa, Ontario
Totally recommended, I am quite happy about this hat, the size is good, the fur opened itself up with the fresh air. I know where I am getting the next hat when need be.


text:
The 2nd Amendment vs the Incorporation Doctrine
The Bill of Rights was a protection against the Federal GovernmentDetails
The Bill of Rights was a protection against the Federal GovernmentDetails
The individuals in this small Idaho community didn't just rant and rave about the evils of federal oppression; they banded together and did something about it.Details
History makes it clear that the Second Amendment is designed to serve four principal purposes.Details
So often in my work here at Tenth Amendment Center, I hear people referring to their rights by Amendment. Unfortunately, doing so creates a misconception of where your rights come from, and the power of government to take them.Details
JEFFERSON CITY, Mo., August 5, 2014 – In a landslide today, Missouri voters took a powerful first step towards a nullification of gun control measures by approving a constitutional amendment "obligating" the state to defend the right to keep and bear arms against all infringements.Details
St. George Tucker on the importance and meaning of the 2nd AmendmentDetails
I recently noticed another nullification happening in the great Centennial State, and I think it provides a valuable lesson for all of us – deal with things in our own house!Details
I spent last week vacationing in Florida. One of the things I really enjoy about getting away from the daily routine is the opportunity to catch up on reading. So, while lounging on the beach, I dug into founding era sources surrounding the proposal and ratification of the Second Amendment. Here are some things that were very clear.
Missouri bill HB 1439, the Second Amendment Preservation Act, was passed by the State House and moved forward in the Senate committee on 04/15/2014 (click here to learn more about this bill).
YOUR ACTION IS NEEDED NOW to make sure the bill is scheduled on the Senate floor for a final vote. Here is what you need to do ensure this bill becomes law in Missouri.Details
The Constitution. Every issue, every time. No exceptions, no excuses.


text:
Question: You have received the following incomplete information about a set
You have received the following incomplete information about a set of currency forwards. All the forwards are for C$1,000 in one year. Complete the followingtable.
View Solution:
View Solution:
Answer to relevant QuestionsComplete the following table. The underlying asset is ounces of gold. Assume noarbitrage.CanComp has a contract to deliver a large computer system to a South African company in one year and would like to hedge the currency risk. CanComp will receive payment of R3.5 million (the currency of South Africa is the ...Ethel decided to invest in the futures market. She entered a long position in 1,000 futures contracts that require a $30,000 initial margin. The maintenance margin is $22,500. Assume that Ethel deposits the minimum amount of ...Calculate the F1, F2, F3, given the following interest rates on zero couponbonds:Mr. Cabinet, your boss at FinCorp Inc., prefers to have his information presented visually. At his request, graph the payoffs (intrinsic values) and profits at expiration for the following option investments.Long call, ...
Post your question


text:
Skip to comments.SFPD officers working with FBI...gather intelligence
Posted on 04/06/2011 3:12:30 PM PDT by Navy Patriot
A recently unearthed agreement between the FBI and the San Francisco Police Department allows city cops assigned to a task force designed to combat terrorist attacks to gather intelligence on individuals even if they arent suspected of a crime, according to groups that have been in a legal fight with the SFPD over the agreement for months.
The Asian Law Caucus and the American Civil Liberties Union obtained a copy of the March 2007 agreement signed by then-Police Chief Heather Fong this week after filing a freedom of information request in November.
Under a policy established in 1990, the SFPD requires reasonable suspicion before officers are allowed to collect information on someone. Those rules were later enforced by court order after allegations surfaced in 1993 that a police officer had been sharing information with an informant for the Anti-Defamation League.
(Excerpt) Read more at sfexaminer.com ...
Back in the old days, San Francisco liberals being the good Marxists they are, feared investigation by the FBI and any other security agencies (including SFPD), because their links to communists, subversives, anti American organizations and their dope stash might come to light.
So, they used city legislation to forbid the SFPD from doing intelligence gathering and investigation of hinkey citizens and aliens, period.
The FBI and cops figured a way to get around the "protect the commies" policy, and now it has come to light.
Interestingly, with Zero's injustice dept. the FBI will now use this to railroad innocent conservatives, as the entire city government of San Francisco, including the police command and intelligence staff, has gone bad.
Where are all those people that say the police will never follow 'those' orders?
Oh this power will never be abused. No sir...
Dead, along with the ones who said: "The (fill in the blank with the name of the nation) army will never fire on the people."
"Where are all those people that say the police will never follow those orders?"
Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.


text:
There is no better way to describe the meaning of the common Costa Rican phrase, Pura Vida, than to say that it's simply a way of life. Its literal translation is "pure life", but this term is also frequently used as a greeting, a farewell, a way of giving thanks, or as a common expression of how things are going. Think of it as the local way of saying "cheers", but way better.
The term Pura Vida is really an expression of happiness and optimism, a belief that no matter what seemingly bad situation you might be in, there are many others out there who are even worse off. It's an expression of hope, of better things to come, and of the laid back lifestyle that Costa Rica is known for.
I read up on the meaning of Pura Vida before I left for Costa Rica, but it wasn't until I heard the locals use it in day to day life that I truly grasped the significance of the phrase. And I have to admit, their genuine belief in the phrase and everything that it stands for is inspiring…
It's a beautiful way of looking at life and it definitely is one of my favourite things about Costa Rica.
PURA VIDA, my friends!
Cultural Close-ups is a series of photographs and stories from around the world that go beyond the pretty sights and famous attractions. If you'd like to contribute a photo and a short story to Cultural Close-Ups, please email your submission to [email protected]
Do you believe in Pura Vida?
Like this post? Pin it for later!


text:
Dear Alumni:
I want to thank you for joining me at the Pan-European Reunion in London. I hope you agree that it was a tremendous weekend, with thought-provoking panels and lively social gatherings in some of London's most incredible venues. The Pan-European Reunion is truly a jewel in the crown of alumni events, and I am pleased that nearly 600 alumni and guests from 37 countries were able to participate.
You can view some of the press coverage the School received over the course of the weekend as well as an article that I wrote in Tuesday's Financial Times on the U.S. economy.
Columbia Business School remains a leader in global management education due––in no small part––to the support of our outstanding alumni network. I hope you will continue to actively participate in the life of the School, including making an annual contribution to the Columbia Business Fund or EMBA Fund. If you have not done so already, please consider making your gift.
Thank you again for being a part of the 2011 Pan-European Reunion. Photos are now available to be viewed online. I hope to see you at another School event soon.
With regards,
Glenn Hubbard
Dean and Russell L. Carson Professor of Finance and Economics


text:
Pics of my Twins:)
Hi Ladies! Sorry I haven't been around a lot lately, I've been quite busy! I have been lurking but haven't had time to post a lot of responses. I wanted to share pics of my girls:)
Melody and Ashley
Ashley and Melody
Melody, still in the NICU but almost home!
So I knew it was going to be difficult having twins, but I didn't expect having to feed them both every 3 hrs, even at night. DH and I are exhausted and bicker all the time now:( I know it will get better! I love these girls so so much!! I just feel bad because when I'm home alone with them and it's feeding time, it never fails that as I'm feeding Melody, Ashley starts screaming because she gets hungry early. I've tried giving her a little more at her feedings to hold her off longer, but she either doesn't take it or takes it and spits it all back up. So I feel bad I have to leave one of them to cry:(
I started out pumping milk and giving mostly formula, because they're both on high calorie formula, but I think I'm going to stop pumping. I've complained in the past about my acne, and it's actually gotten worse. I've read a lot of women say theirs didn't go away until they stop breastfeeding because hormones are still out of whack. I feel selfish, but I'm in physical pain from it. I have these huge painful cysts all over my back, chest, shoulders, arms, neck and face. My neck is actually swollen, and it hurts to shower from the spray from the shower head. And I don't wear a bra unless I absolutely have to (thank goodness I have a really small chest lol).
Overall things are going well! I hope everybody else is good also!
Re: Pics of my Twins:)
I'm sorry things are rough :(. As an herbalist I can tell you that a lot of acne problems are caused by an overwhelmed liver. When the liver is working overtime to handle hormones, whatever toxins (or hormones) its not able to process find their way to the skin. Which is why a lot of women break out during their period and during and after pregnancy. Eating liver supporting foods can really help - beans, eggs, leafy greens. Cut out refined sugar and flour - eat whole foods. Just a suggestion, I hope things improve and congratulations on the babies!
Re: Pics of my Twins:)
They're sooooo beautiful!!!! I hope things get better as far as their feedings go.
Re: Pics of my Twins:)
Thanks ladies:) the feedings are only difficult because they're both fussy after they eat... They're both on iron drops which are harsh on their tummies, so they cry a lot:(
Movlin- that's great advice! I ate pretty good while I was pregnant and still had bad acne, but I didn't eat as well as I should've. And the last two weeks I've been eating a LOT of sugar. I'm sure there's a link. I'm going grocery shopping tomorrow so I'll pick up healthy foods. Plus it'll help me lose the last 15 lbs!
Re: Pics of my Twins:)
Beautiful photos! I didn't realize they had different hair colours, so cute!
I have never heard of increased acne from breastfeeding personally but it sounds very painful. My husband gets the kind of acne that is painful.
May I ask why you can't feed both of them at once? I realize it would be harder but can't you sit cross legged and have each in the crook of your knee and hold both bottles? I realize holding them close is better but if one is hungry before the other???
Re: Pics of my Twins:)
I love that they have different colored hair! Such sweet babies. Hang in there :)
Re: Pics of my Twins:)
I know it's funny that their hair is different because they're identical! I think as Melody gets more it will look more like Ashley's. They also look a little different, but that's only because Melody is smaller than Ashley. At their last dr apt, Ashley was 7lb2oz, and Melody was 5lb11oz. They definitely have the same features and facial expressions.
I have thought about feeding them at the same time but wasn't sure how I could juggle that lol. I have friends with twins so I think I'm going to ask about that. It would also give me more time between feedings to get things done:)
Re: Pics of my Twins:)
They are so cute! I hope things start to get better with the feedings soon!
Re: Pics of my Twins:)
love the photos! i can't imagine taking care of twin newborns, sweetie. you are doing a great job.
Re: Pics of my Twins:)
The are so precious. I love seeing pictures of your sweet girls.
Re: Pics of my Twins:)
They are both so precious :)
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|Alison Murray; Margaret Williams; Jayne Parker; Victoria Marks; Mark Baldwin; Carol Murcia; Wayne McGregor; Susan Kozel
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|Describes the third Dance Screen festival, held at The Place Theatre in London, autumn 1997. Films discussed include Bare feet and crazy legs, directed by Alison Murray; Macbeth taped, directed by Margaret Williams; The whirlpool, directed by Jayne Parker; Men, directed by Victoria Marks and Margaret Williams; and Virtual insanity, directed by Jamiroquai. Also discussed are a CD-ROM, Who killed me?, by Mark Baldwin and Carol Murcia; and digital choreography projects by Wayne McGregor and Susan Kozel.
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If you are looking to get away from the hustle and bustle of Marrakesh, then this villa is the perfect place. We spent three very relaxing days here and the staff were wonderful. If you do get bored, you can take a trip into Essaouria where there are plenty of things to do. I would highly recommend staying here... If we go again, we would probably stay for a full week next time.
- Official Description (provided by the hotel):
- A wonderful and peaceful place with a sea view, Gonatouki is located at roughly 10km from the beach.With its 10 bedrooms and suites you will be enchanted by the villa, its architecture and its 2 swimming pools (one with a kids' pool).A place you will never forget!!! ... more less
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Permian Basin RoyaltyOwners of Permian Basin Royalty (NYSE: PBT) shares as of market close today will be eligible for a dividend of 7 cents per share. At a price of $13.14 as of 9:34 a.m. ET, the dividend yield is 6.6%. The average volume for Permian Basin Royalty has been 162,700 shares per day over the past 30 days. Permian Basin Royalty has a market cap of $615.7 million and is part of the energy industry. Shares are up 7.8% year-to-date as of the close of trading on Tuesday. STOCKS TO BUY: TheStreet Quant Ratings has identified a handful of stocks that can potentially TRIPLE in the next 12 months. Learn more. Permian Basin Royalty Trust owns overriding royalty interests in various oil and gas properties in the United States. The company has a P/E ratio of 15.73. TheStreet Ratings rates Permian Basin Royalty as a hold. The company's strengths can be seen in multiple areas, such as its revenue growth, largely solid financial position with reasonable debt levels by most measures and increase in net income. However, as a counter to these strengths, we find that the growth in the company's earnings per share has not been good. You can view the full Permian Basin Royalty Ratings Report now.
- See our top-yielding stocks list.


text:
Hi Guys,
I'm trying to track a few outgoing mail from our Exchange server which aone of our users says the recipient never got.
They were sent by the user to an @avit-systems.dk address.
When I check the exchange tracking logs, exchange says they were delivered fine (as I expected they were), but to a mail4.nordjyske.dk domain.
(Message transferred to mail4.nordjskye.dk through SMTP)
Is this possibly normal, or could it be a DNS problem perhaps? I'm suspecting normal, and the problem may be their end somewhere.
Jun 24, 2010 at 5:01 UTC
Sounds like they got there
an MX lookup on avit-systems.dk gives mail4.nordjyske.dk as their second preference mail record.
Ask them to check there mail server logs, it may have been junked in the recipients outlook as well.
3 Replies
Jun 24, 2010 at 5:01 UTC
Sounds like they got there
an MX lookup on avit-systems.dk gives mail4.nordjyske.dk as their second preference mail record.
Ask them to check there mail server logs, it may have been junked in the recipients outlook as well.
Jun 24, 2010 at 5:30 UTC
Hi Griff
for the benfit of all reading this thread, I'll cover this from the start, so sorry if this is "stuff you already know".
SMTP is a store and forward protocol which means that email can pass through many systems before it reaches its final destination. Each mail server can use a variety of methods to work out where to forward the mail onto (normally this will be DNS, but note that this doesn't mean Internet DNS) and if the mail message is unable to be delivered (for whatever reason) it should report a failure message back to the sender.
A few problems with this are:
- a mail server might simply hold a mail for a long time before passing it on... it isn't obliged to report this (only complete failure).
- some mail servers don't report on failure due to the potential to abuse this method for sending spam (a bad idea IMHO, let a spam filter deal with any resulting spam)
- any spam filtering that you have in place might block a fail mail message
- when a mail server accepts an email you can't tell if it has reached the destination only the next hop and you can't tell if there are many or few other hops to go.
In your case, the Internet DNS (check this with nslookup in a command prompt) shows:
> set q=mx
> avit-systems.dk.
Server: dnsserver.***.***.***
Address: xxx.xxx.xxx.xxx
Non-authoritative answer:
avit-systems.dk MX preference = 20, mail exchanger = mail4.nordjyske.dk
avit-systems.dk MX preference = 10, mail exchanger = mail2.nordjyske.dk
So, in response to your question it looks fine. Your only next step is to follow up with either the adminstrator for avit-systems.dk or (and possibly less fruitfully) the administrator for nordjyske.dk
I would be inclined to contact avit-systems.dk in the first instance. They may have a spam or security system in place that is blocking the email; they should also be able to follow up with nordjyske.dk as they are probably a customer of theirs!
BTW dnsstuff.com is a useful site for checking DNS things, some useful free tools (notably the whois tool), but nslookup is also very useful... you can query remote DNS servers with nslookup, just use the "server" command within nslookup.
Hope that this helps
Jun 24, 2010 at 8:21 UTC
So technically speaking SMTP is not a store and forward protocol. It's simply a protocol for transferring email from one box to another one. What the mail servers do with it at that point is really up to them.
This discussion has been inactive for over a year.
You may get a better answer to your question by starting a new discussion.


text:
Recently, we described a splice variant of the human natriuretic peptide receptor type B (NPR-Bi) in human proximal tubule cells [immortalized human kidney epithelial cells (IHKE-1) that lacks a functional guanylate cyclase domain (Hirsch JR, Meyer M, Mägert HJ, Forssmann WG, Mollerup S, Herter P, Weber G, Cermak R, Ankorina-Stark I, Schlatter E, and Kruhøffer M. J Am Soc Nephrol 10: 472–480, 1999). Its signaling pathway does not include cGMP, cAMP, or Ca2+ but leads to inhibition of K+ channels. In patch-clamp experiments, effects of tyrosine kinase receptor blockers on C-type natriuretic peptide (CNP)-mediated depolarizations of membrane voltages (Vm) of IHKE-1 cells were tested. The epidermal growth factor (EGF) receptor blocker genistein (10 μM) abolished the effect of CNP (0.2 ± 0.4 mV, n = 7), and comparable results were obtained with 10 μM daidzein (n = 8). Aminogenistein (10 μM, n = 5) and tyrphostin AG1295 (10 μM, n = 5) had no significant effects. EGF (1 nM) hyperpolarized cells by –5.3 ± 0.8 mV (n = 5). This effect was completely blocked by genistein or daidzein. The Cl– channel blocker NPPB (10 μM, n = 5) inhibited the EGF-mediated hyperpolarization. mRNA expression of NPR-B and NPR-Bi shows reversed patterns along the human nephron. NPR-B is highly expressed in glomeruli and proximal tubules, whereas NPR-Bi shows strong signals in the distal nephron. Expression of NPR-Bi in the cortical collecting duct was also confirmed with immunohistochemistry. In other human tissues, NPR-Bi shows strongest expression in pancreas and lung, whereas in the heart and liver NPR-B is the dominating receptor. In conclusion, CNP inhibits an apical K+ channel in IHKE-1 cells independently of cGMP and so far this effect can only be blocked by genistein and daidzein. Tyrosine phosphorylation might be the missing link in the signaling pathway of CNP/NPR-Bi.
- C-type natriuretic peptide
- signal transduction
- tyrosine kinase
- patch clamp analysis
- proximal tubule
- kidney
natriuretic peptides are structurally related peptides that bind to different receptors and display a variety of biological actions (6, 16). Although quite a lot is known about the actions of ANP and the related urodilatin that binds, similar to BNP, to the natriuretic peptide receptor (NPR)-A (GC-A), little is known about C-type natriuretic peptide (CNP) (1, 11, 12). CNP, which is found in the plasma and urine as a 53- and 22-amino acid ring-forming peptide, binds to the NPR-B (GC-B) receptor, which leads to an increase in intracellular cGMP (4). Recently, a splice variant of the NPR-B receptor was detected and described as NPR-Bi. This receptor carries a 71-bp insert on the mRNA level, leading to a frameshift and truncated protein when translated (8). Due to the generation of an early stop codon, the receptor lacks a functional guanylate cyclase domain and does not increase intracellular cGMP when activated by CNP (8). cGMP-independent signaling for natriuretic peptides has so far only been described for the NPR-C or "clearance" receptor that can influence the adenylate cyclase activity through G proteins (3, 13). We speculated that tyrosine phosphorylation might be the signaling pathway for the NPR-Bi receptor (7, 8).
It is known that phosphorylation processes regulate the activity of guanylate cyclase receptors (15). Recently, it could be shown for the guanylate cyclase receptor GC-C, which is bound by guanylin and uroguanylin, that not only serine/threonine-specific phosphorylation steps regulate guanylate cyclase receptors but also tyrosine phosphorylation (5).
In this study, we demonstrate that CNP inhibits K+ conductance independently of cGMP and that this effect can be blocked only by genistein and daidzein but not by the structurally related aminogenistein or another tyrosin kinase receptor blocker tyrphostin AG1295. Furthermore, we show the expression pattern of NPR-Bi in human tissues, especially in various segments of the human kidney.
Cell culture. Immortalized human kidney epithelial (IHKE-1) cells (derived from human embryonic kidneys) were cultured as described previously (18). In short, IHKE-1 cells (passages 162-188) were grown in 50-ml tissue culture flasks (Greiner, Frickenhausen, Germany) in Dulbecco's modified Eagle's/F-12 medium (1:1) containing 15 mM HEPES, pH 7.3, 1.6 nM EGF, 100 nM hydrocortisone, 83 μM transferrin/insulin, 29 nM Na2SeO3, 10 mM NaHCO3, 20 mM l-glutamine, 1,000 U/l penicillin/streptomycin, and 1% fetal calf serum. Cells were incubated at 37°C in an atmosphere of 5% CO2-95% air. After 7 days, the confluent monolayers were trypsinized with Ca2+- and Mg2+-free phosphate-buffered saline and 0.05% trypsin-EDTA (Biochrom, Berlin, Germany). Cells grew polarized on glass coverslips, with the apical surface facing upward.
Patch-clamp studies. Coverslips with confluent IHKE-1 monolayers were mounted at the bottom of a perfusion chamber on an inverted microscope (Axiovert 10, Zeiss, Oberkochen, Germany). The perfusion chamber was continuously perfused at a rate of 10–20 ml/min at 37°C with a standard solution containing (in mM) 145 NaCl, 1.6 K2HPO4, 0.4 KH2PO4, 5 d-glucose, 1 MgCl2, and 1.3 Ca2+-gluconate, pH 7.4. Cells were rinsed for at least 20 min before the electrophysiological measurements.
Membrane voltages (Vm) were measured with the slow whole cell patch-clamp technique. For this method, pipettes were filled with a solution containing (in mM) 95 K+-gluconate, 30 KCl, 4.8 Na2HPO4, 1.2 NaH2PO4,5 d-glucose, 0.73 Ca2+-gluconate, 1 EGTA, 1.03 MgCl2, and 1 ATP, pH 7.2. To this solution 162 μM nystatin was added before use. Patch pipettes had an input resistance of 2.5–12.5 MΩ. Vm was measured in the current clamp mode of a patch-clamp amplifier (U. Fröbe, Physiologisches Institut, Universität Freiburg, Germany) and recorded continuously on a pen recorder (WeKaGraph WK-250R, WKK, Kaltbrunn, Switzerland).
RT-PCR analysis. Total RNA was isolated using the RNeasy-kit (Qiagen, Hilden, Germany). Isolated total RNA was incubated with 10 U DNase I (Promega, Heidelberg, Germany) at 37°C for 1 h to digest isolated traces of genomic DNA. RNA and DNase I were then separated by an additional cleanup step using a new RNeasy column. cDNA first-strand synthesis was performed in a total reaction volume of 30 μl containing 5 μg total RNA, 10 nM dNTP-Mix (Biometra, Göttingen, Germany), 1 nM p(dT)10 nucleotide primer (Boehringer, Mannheim, Germany), and 200 U molony murine leukemia virus reverse transcriptase (Promega). Of each cDNA first-strand reaction mixture, was then subjected to a 50-μl PCR reaction in a UNO II thermo cycler (Biometra) using 20 pmol of each primer and 1 U of Taq DNA polymerase (Qiagen). Reaction conditions were as follows: 3 min at 94°C, 30 s at 59°C, and 1 min at 72°C, 1 cycle; 30 s at 94°C, 30 s at at the optimal annealing temperature (OAT), and 1 min at 72°C, 30 cycles; and 30 s at 94°C, 30 s at OAT, and 10 min at 72°C, 1 cycle. PCR reaction products were analyzed by agarose gel electrophoresis. Positive signals obtained from PCR experiments were sequenced by SeqLab (Göttingen, Germany). The following PCR primers were used (listed in 5′- to 3′-direction). The sequence is followed by the expected fragment length for the respective sense and antisense primer: NPR-Bi sense: GAC TCT CAC TCC AGC CCT AGT CTC, NPR-Bi antisense: TTC AGC GCT TGA CCA TTA GAC TCC, fragment length: 169 bp, OAT = 60°C; NPR-B sense: GAG ACG ATT GGG GAT GCT TA, NPR-B antisense: TTC AGC GCT TGA CCA TTA GAC TCC; fragment length: 277 bp, OAT = 60°C; GAPDH sense: CTG CCC CCT CTG CTG ATG, GAPDH antisense: GTC CAC CAC CCT GTT GCT GT, fragment length: 614 bp, OAT = 61°C.
Immunocytochemistry. Kryo slices of a human kidney were blocked for 15 min at room temperature with 1% blocking agent (Roche, Mannheim, Germany). The primary polyclonal antibody against NPR-Bi (Immundiagnostik, Bensheim, Germany) was incubated overnight at 4°C in a wet chamber. After three washing steps in PBS, the secondary antibody (goat-anti-rabbit, Vector, Burlingame, CA) was incubated for 45 min followed by three more washing steps in PBS. The kryo slices were then incubated for 45 min in streptavidin, Alexa Fluor 594 Conjugate (Mobitec, Göttingen, Germany) followed by five washing steps in PBS. Finally, the slices were covered with mounting media containing DAPI (Vector).
Biochemicals. Human CNP was kindly provided by Dr. Knut Adermann (IPF Pharmaceuticals, Hannover, Germany). Genistein, daidzein, aminogenistein, and tyrphostin AG1295 were supplied by Calbiochem (Bad Soden, Germany). All other standard chemicals were supplied by Calbiochem, Sigma (Taufkirchen, Germany) or Merck (Darmstadt, Germany).
Statistical analysis. Data are presented as means ± SE, with the number of experiments given in brackets. For statistical analyses, Student's paired and unpaired two-sided t-tests were used. For paired comparisons, each effect was compared with its own averaged pre- and postexperimental controls. A P value <0.05 was considered significant and is indicated by an asterisk.
To verify if the cGMP-independent CNP-induced depolarization in the human proximal tubulus cell line IHKE-1 is specifically blocked by genistein or generally blocked by a variety of tyrosine kinase receptor blockers, we tested the epidermal growth factor (EGF) receptor blocker genistein, its "inactive" form daidzein, the structurally related aminogenistein that is also an inhibitor of the p56lck tyrosine kinase, and the PDGF receptor blocker tyrphostin AG1295. In 57 patch-clamp experiments, the membrane voltage (Vm) of IHKE-1 cells was –42 ± 1 mV. In seven paired experiments, CNP (10 nM) depolarized Vm by 2.8 ± 0.4 mV. In the presence of genistein (10 μM), the CNP-induced depolarization was abolished (0.2 ± 0.4 mV). After the washout of genistein, CNP depolarized Vm again by 1.4 ± 0.4 mV (Fig. 1). As a negative control, we used daidzein, the inactive form of genistein. To our surprise, daidzein (10 μM) reversed the CNP-induced depolarization (n = 8). Aminogenistein (10 μM, n = 5) and tyrphostin AG1295 (10 μM, n = 5) had no significant effect on the CNP-induced depolarization (Fig. 1).
To verify the specificity of genistein and daidzein, both were tested on their inhibitory effect of the EGF-mediated signaling pathway. In five paired experiments, EGF (1 nM) hyperpolarized Vm by –5.3 ± 0.8 mV (Fig. 2). In the presence of genistein, this effect was fully inhibited to 1.2 ± 1.1 mV and after the washout of genistein also fully reversible (–4.1 ± 0.9 mV). Daidzein again mimicked the effect of genistein, clearly showing that this substance is not inactive in the human proximal tubule cell line IHKE-1 (Fig. 2). Although the CNP-induced depolarization is due to the inhibition of a K+ channel (7–9), the EGF-induced hyperpolarization is due to the inhibition of a Ca2+-dependent Cl– channel since the Cl– channel blocker NPPB (10 μM) blocked the EGF effect on Vm (Fig. 2). Other Cl– channel blockers, such as DIDS and SITS, and Na+ channel blockers, such as amiloride, had no significant effect on the EGF-mediated hyperpolarization (data not shown). EGF also did not interact with CNP as there was no significant effect of EGF on the CNP-induced depolarization (2.6 ± 0.4 vs. 2.7 ± 0.6 mV, n = 6). This demonstrates that EGF and CNP act through independent pathways as shown in a simplified cell model in Fig. 3.
Because we were interested in the distribution of NPR-Bi and NPR-B in the human kidney, we performed RT-PCR on isolated glomeruli and tubules to check for their expression pattern along the nephron. Figure 4 shows the interesting result. Although NPR-B is mainly and strongly expressed in glomeruli and proximal tubules, NPR-Bi is weakly expressed in proximal tubules, stronger in thick ascending limbs, and predominantly expressed in collecting ducts. Because the PCR was performed with the same mRNA/cDNA batches for NPR-B and NPR-Bi and each sample had its own GAPDH control, the data can be seen semi-quantitatively, meaning expression of NPR-B is increasing toward the proximal part of the nephron, whereas that of NPR-Bi is increasing toward the distal parts of the human nephron (Fig. 4). This result is also confirmed by immunocytochemistry, which shows a clear signal of the antibody against NPR-Bi in the luminal membrane of the collecting duct (Fig. 5). Due to the interesting reversed distribution pattern of NPR-B and NPR-Bi in the nephron, we performed RT-PCR with different human tissue samples to monitor the distribution of the two human receptors in other tissues. Two signals of NPR-Bi clearly stuck out compared with NPR-B. The expression in lung and pancreas was dominated by NPR-Bi (Fig. 6). NPR-B expression was strongest in the heart and liver. Keeping in mind that lung, pancreas, and colon are the three tissues mostly affected in cystic fibrosis, we also performed PCR experiments with human colon tissues, confirming that both receptors are equally well expressed (data not shown).
CNP is known to bind the natriuretic peptide B (NPR-B/GC-B) receptor and increase intracellular cGMP. It is known to display biological actions in the cardiorenal system, bronchial tree and pulmonary vasculature, and the endocrine, gastrointestinal, and neuronal systems (4). Recently, it was shown that CNP can also act independently of cGMP by inhibiting a Ca2+-dependent, intermediate-conductance, hIK1-like K+ channel in human IHKE-1 cells derived from the human renal proximal tubule (8). Besides the well-known NPR-B receptor, a splice variant (NPR-Bi) was found that is the dominant pathway for CNP in these cells. The NPR-Bi receptor lacks a functional guanylate cyclase domain, thus inhibiting the hIK1-like K+ channel cGMP independently. Furthermore, we were able to show that neither Ca2+ nor cAMP played any role in the regulation of this K+ conductance (8). Due to the structure of the receptor and a recent report that demonstrated a key role for tyrosine phosphorylation in the activity of the related GC-C receptor (5), we tested various tyrosine kinase blockers. From these inhibitors, only genistein, a known inhibitor of the EGF receptor (2), and its inactive form, daidzein, were able to block the CNP-induced depolarization of membrane voltage. Neither the structurally related aminogenistein nor the PDGF receptor blocker tyrphostin AG1295 had any significant effects. Although genistein and daidzein also blocked the EGF-mediated hyperpolarization, they displayed no direct effect on the hIK1-like K+ channel itself (8). A direct interaction independent of tyrosine phosphorylation had been reported for some K+ channels, a Cl– channel, and the Na+-2Cl–-K+ cotransporter (14, 19, 20). In IHKE-1 cells, daidzein was also not an inactive substance but acted like genistein. So far, these two substances are the only blockers capable of inhibiting the CNP-mediated signaling through NPR-Bi, which is most likely related to tyrosine phosphorylation. The hIK1-like K+ channel apparently plays an important role in these human proximal tubule cells because it can be blocked by ANP, BNP, and urodilatin cGMP dependently through NPR-A/GC-A (9), by CNP cGMP independently through NPR-Bi (8), and by guanylin, uroguanylin, and STa cGMP dependently through GC-C (17). Furthermore, cGMP inhibits this K+ channel directly from the extracellular as well as the intracellular surface (10) as displayed in Fig. 7. The diverse expression pattern of NPR-B and NPR-Bi in the human nephron clearly indicates different tasks for CNP through these receptors. The cGMP-independent pathway seems to play an important role in the human collecting duct, where NPR-B is not expressed at all and NPR-Bi showed its strongest signal on the mRNA and protein level. When the mRNA expression pattern of NPR-Bi in various human tissues is viewed, it is striking that signals from lung and pancreas stick out. The fact that NPR-Bi and NPR-B are also strongly expressed in the human colon indicates a role for NPR-Bi in cystic fibrosis-related tissues. Regulation of hIK1 in the basolateral membrane of lung or colon cells by tyrosine phosphorylation might be a key element in the regulation of Cl– secretion in these cells. Further investigations are needed to clarify the role of NPR-Bi and its interaction with hIK1 and CFTR in human cell types such as Calu-3 (lung), T84 (colon), and CF-PAC (pancreas).
This work was supported by the Deutsche Forschungsgemeinschaft (Schl 277/5–5 to 5–6 and 11–1).
The authors gratefully acknowledge the expert technical assistance of M. Eich, U. Kleffner, U. Siegel, and H. Stegemann.
The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked ``advertisement'' in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
- Copyright © 2003 the American Physiological Society


text:
Dr. Fawad Aryanpure MD Patient Reviews
- Family Medicine Tuscaloosa, AL
Overall Rating
10 Patient Reviews
- Friendly Staff
- Promptness
- Spends Time With Patients
- Bedside Manner
- Fair and Accurate Diagnosis
- Easy Appointments
- Wait Time 15 minutes
- Appropriate Followup
Showing 1 - 10 reviews
5.0 of 5
June 11th, 2017
Wonderful Doctor !
He's amazing ! Very intelligent , professional , thorough and pleasant ! I'd highly recommend! He has a wonderful demeanor and is very caring and provides excellent care ! He spends time with patients and is very kind and has a lovely personality and provides excellent care.
1.0 of 5
July 3rd, 2015
I've been seeing Fawad Aryanpure for around two years; honestly the worst doctor I've ever been around. Cocky, arrogant, treats people like he is above them, etc. One thing that stood out to me is how often he makes assumptions and jumps to conclusions. This in turn causes him to be rude in situations where it is unnecessary, but all is fine because he apologizes afterwards... Also, someone close to me went to see him, and he noticed a rash on her skin. Instead of trying to find out what the cause was, he suggested she research it, find out what it is, and then get back with him after she decides what she wants to do about it. This man is pathetic. From my experience seeing him, he seems to be concerned primarily with his looks and salary, with little emphasis on actually being a doctor. If you want a cocky doctor who will talk to you like you're an idiot, check him out. Otherwise, I would recommend seeing a veterinarian over this greaseball.
1.0 of 5
May 14th, 2015
Left my husband in a hospital bed to die, needs his license revoked. Bedside manner is horrible, just worried about his looks.
1.0 of 5
February 10th, 2017
5.0 of 5
February 3rd, 2017
1.0 of 5
January 8th, 2017
2.0 of 5
September 9th, 2016
5.0 of 5
August 16th, 2016
1.0 of 5
October 22nd, 2015
3.7 of 5
October 23rd, 2014
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text:
beautiful.bizarre is a high end contemporary art publication which showcases the work of leading & emerging artists, in various mediums including traditional, digital, sculpture and photography, in a beautifully designed & published "coffee table" style book.
Their mission is to encourage, grow and promote talented leading and emerging artists whose work goes beyond conservative contemporary art. beautiful.bizarre is the place where the unique, the evocative, and the beautifully bizarre are celebrated & readers can discover a decadent alternative to mainstream art.
FEATURED ARTISTS: HUSH, Stephen Mackey, Mab Graves, Olivier Valsecchi, Leilani Bustamante, Sail, Kirsty Mitchell, Julia deVille, Kari-Lise Alexander, Bastien Lecouffe Deharme, Beatriz Mutelet, Jel Ena, Gaia Alari, Alex Garant


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[Jan 28th 2016, 10:27am] Twyrdyk: hey guys I have a question for you... tell me where is Seaways island with Eagle Warrior and Mercenary?? How to get there?? :
[Dec 22nd 2015, 12:56pm] Shootme: easy question for you Becouse crash? ehh 100% better Crash ,than only 5 players ?
[Dec 22nd 2015, 12:55pm] Shootme: Becks why u dont open The Best Tibafun old times ?????
[Dec 22nd 2015, 12:55pm] Shootme: Whyme: MEEN only 9ppl online why you make peroids its no sense !! all waiting for biggest exp and no plaaay haha 9 ,old times 90 xd
[Dec 22nd 2015, 12:52pm] Shootme: Becks stupid klds never open old Tibiafun becouse crash ? hahahahah better crash ,than 0 plaeyers xd
[Dec 22nd 2015, 12:51pm] Shootme: all People ! yeeeeeeeeeeeeee
[Dec 22nd 2015, 12:51pm] Shootme: who want old tibiafun?
[Dec 22nd 2015, 12:48pm] Shootme: if becks St.up.id becouse he never start old times
[Dec 22nd 2015, 12:47pm] Shootme: poeople need old times Tibiafun .the bedt Time for Tibiafun.eu 20012-2013
[Dec 22nd 2015, 12:47pm] Shootme: onlyA lot of
[Dec 22nd 2015, 12:46pm] Shootme: Yes Old Time Tibiafun 20012-2013 Big player Online
[Dec 21st 2015, 2:04pm] Assddd: NOW 0 ppl u see it look all ppl want back tibiafun eu to old times u dont leasten them why ? and now u have 0 ppl
[Dec 21st 2015, 2:04pm] Assddd: BECKS MAKE OLD TIBIAFUN 2012 OLD MAP, OLD SYSTEMS, OLD SPELLS , OLD MONSTER,and make back client 7.6, i know there will be crashes but look u will have around 60 ppl
[Nov 7th 2015, 12:48pm] Hwpa: k
[Oct 25th 2015, 11:14am] Assddd: ASA
[Oct 15th 2015, 2:55pm] Whyme: MEEN only 9ppl online why you make peroids its no sense !! all waiting for biggest exp and no plaaay ............
[Sep 28th 2015, 8:21pm] Shootme: when information about exp stage ;DDDDDDDDDDDDDDDDDD
[Sep 28th 2015, 8:19pm] Shootme: yeeeee
[Sep 14th 2015, 10:03am] Shootme: Becks ,When you add information when start server?
[Sep 10th 2015, 10:50pm] Shootme: if fixed manarune and f attack ,maybe play
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International Board. Everything that doesn't fit into the general boards should be posted in here.
and now he's not thinking about relaunch?
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Is there any condensed answer on how to get XP pro sp2 PCs to show in a network scan? I ran a scan and it picked up all our servers right away and about 8 out of 80 PCs all running xp pro sp2. I have been trying to get my laptop to show up. It shows up as an unknown know but I'm not sure what out of all the steps I've done got it that far (dcom, wmi, netsh firewall command, etc) I get scan errors for it and one other pc but nothing for a majority of the PCs on our network. Please help! This product seems great but if I cant get it to show these PCs I'm not sure I can use it.
Thanks for any help you can provide.
This topic was created during version 1.7.
The latest version is 7.5.00101.
1 Reply
Jan 10, 2008 at 3:49 UTC
just noticed that one of the pcs I've been working on trying to get it show up isnt even running windows firewall... it is disabled... what else can cause it not to show up?
This discussion has been inactive for over a year.
You may get a better answer to your question by starting a new discussion.


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Ironman Inspire Treadmill Review
treadmill Doctor Note :
Pacemaster makes a more compelling case in this range. You can also get much higher quality units from Sole and Smooth in this range.
Hard to justify an Ironman for $1600. When we took apart our test model, we couldn't believe the cheap parts inside. While everyone got better, Ironman decided to go down in quality.


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Milestone Technical Institute
(713) 988-1211 (888) 988-1211 9800 Centre Parkway, Suite 870, Houston, TX 77036 M-F 9am-6pm, Sa 9am-2pm, Su Closed (Saturday is strictly by appointment.) Official site
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Milestone Technical Institute is a computer training facility offering short-term courses in desktop application software, hardware maintenance and assembly, networking administration and Web application. MTi offers SAP, Primavera P6, CompTIA A+,Network+, MCSE, MCSA, CISCO and CyberSecurity Certification Trainings. Become an IT Administrator with Milestone Technical Institute! Based in Houston, We are an accredited career school that provides a range of in-class IT training programs, including an IT Administrator certification program, which covers A+ and MCSA certification topics. All our programs can also be studied online by students living in Texas and throughout the U.S. Tuition assistance is available for military members and those who are recently unemployed and receiving benefits. Milestone Technical Institute is an approved vendor for Texas Workforce Solutions.
Traveler's Check, Invoice, Visa, Check, Cash, MasterCard, and Financing gladly accepted


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CHATTANOOGA, Tenn. – After Day One of the 2016 Defense Soaps and Flips Wrestling Southern Scuffle, the University of Pennsylvania wrestling team will send two wrestlers to the quarterfinals, with another seven still competing in the consolation rounds.
No. 3 seed Lorenzo Thomas won two matches at 184 pounds to reach the quarterfinals, defeating Air Force's Anthony McLaughlin, 9-1, and Stanford's Garret Krohn, 5-2.
No. 10 Casey Kent won three matches at 174 pounds, including a 12-0 major decision over the No. 7 seed Ben Stroh of Wyoming in the third round.
Lorenzo Thomas began his tournament with a 9-1 major decision over Air Force's Anthony McLaughlin. Thomas scored a quick takedown and added two points of nearfall for a 4-1 lead after one period. In the third, he took advantage of a penalty point on McLaughlin for stalling, shooting right in on a takedown to secure the bonus. In the third round, he had a takedown in the first period, and added an insurance score in the third period for a win over Krohn.
On Saturday, he will wrestle Oklahoma State's Nolan Boyd in the quarterfinals. Boyd is the No. 6 seed in the tournament, and ranked No. 18 nationally.
Following a workman-like 4-0 win over Duke's Alec Schenk in the first round, No. 10 seed Casey Kent opened a big lead on Chattanooga's Barnett Walthall en route to a 10-4 win in the second round. In the third round, he again put up a big point total. He took Stroh down quickly, and added four nearfall points while building a big base of riding time. After a takedown in the second, Kent added one more takedown in the third period for the major decision.
In Saturday's quarterfinals, Kent will wrestle No. 2 seed – and national No. 2 – Kyle Crutchmer of Oklahoma State. Crutchmer is a returning All-American who finished fifth last year.
Penn had seven wrestlers competing in the Round of 16 in the Championship Bracket, but No. 3 C.J. Cobb, No. 7 Caleb Richardson, May Bethea, Ray Bethea, and Frank Mattiace all suffered losses to move down to consolation rounds.
Richardson began his day with a convincing 20-5 technical fall of Edinboro's Tony Recco. Richardson connected for six takedowns in the match, adding two sets of nearfall and a reversal to end the match just shy of the six-minute mark. In the Round of 16, two takedowns from West Virginia's Keegan Moore in the second period were the difference in a 5-2 decision.
One of the few Penn grapplers to draw a pigtail match, C.J. Cobb began his day with a 12-4 major decision over Cleveland State's Nick Montgomery. Cobb finished five takedowns for the win. In his second match, he was able to score the bout's only takedown in the first period. That score was enough for a 3-2 win over Air Force's Alex Mossing. In the third round, Duke's Mitch Finesilver scored two takedowns quickly in the first period to build a lead. After Cobb closed the gap a bit in the second period, a takedown and two quick nearfall in the third iced a 10-6 decision.
Arguably the biggest win of the first session came from May Bethea at 157 pounds. After falling behind Minnesota's Larry Early III, 4-1, Bethea rallied for an 11-7 win over one the nation's top recruits from the Class of 2015. After falling behind in the opening moments of the match, Bethea put together an escape, takedown and two points of nearfall in the third period for the win. In the Round of 16, two-time All-American Mitch Minotti of Lehigh edged Bethea, 2-0, on riding time and an escape.
Ray Bethea was tied with Christian Maroni of Gardner-Webb in his first match, but an escape and then a blast double in the final 0:30 gave Bethe a 5-2 win. Up next for Bethea was two-time national champion Alex Dieringer of Oklahoma State. The No. 1 seed in the tournament, Dieringer lived up to that bulling with a 20-0 technical fall.
Frank Mattiace dominated the third period against Michigan State's Jacob Cooper, scoring three takedowns to blow open the bout for an 11-2 major decision. Mattiace had five takedowns in the match, including one in the first period which led to almost 2:30 of riding time following one period. Two-time All-American Conner Hartmann, the No. 2 seed, broke open a scoreless match with a takedown in the second period, and Mattaice was defeated, 5-1.
Joe Heyob gave up two takedowns in the first period against Gardner-Webb's Hunter Gamble, and he couldn't recover in a 7-4 loss. In the consolation bracket, Heyob was able to complete the rally as he scored with 0:03 left to defeat Army West Point's Samson Imonode, 4-3. Heyob finished his day with a 15-4 major decision over Minnesota's Robert Stevenson. After conceding the first takedown, Heyob reversed and added four nearfall before the end of the first period. He would add takedowns in the final two periods and a set of nearfall for the big win.
Heavyweight Patrik Garren scored a takedown with 25 seconds remaining in his first round match with Chattanooga's Connor Tolley, breaking a tie for a 6-4 win. In his second match, he scored a takedown in the third period to take a lead on No. 5 seed – and national No. 12 – Riley Shaw of Cleveland State, but Shaw countered with an escape and a takedown of his own with 10 seconds left for a 5-3 win. Garren would be eliminated following a 12-2 loss to Gardner-Webb's Boyce Cornwell.
Brooks Martino lost his first bout to the No. 5 seed – and national No. 12 – Dylan Cottrell of West Virginia, 4-1, but moved on to the second day following medical forfeits from his next two scheduled opponents.
133 - #10 Caleb Richardson
First Round: Bye
Second Round: def. Tony Recco (Edinboro), 20-5
Third Round: lost to Keegan Moore (West Virginia), 5-2
141 – Marc Mastropietro
First Round: bye
Second Round: lost to #4 Tommy Thorn (Minnesota), 3-1
Consolation Second Round: lost to Jayce Carr (Cleveland St.), 3-2
141 – A.J. Vindici
First Round: lost to Tyler Buckiso (The Citadel), 5-2
Consolation First Round: lost to A.C. Headlee (North Carolina), 15-4
149 - #3 C.J. Cobb
First Round: def. Nick Montgomery (Cleveland State), 12-4
Second Round: def. Alex Mossing (Air Force), 3-2
Third Round: lost to Mitch Finesilver (Duke), 10-6
157 – May Bethea
First Round: Bye
Second Round: def. Larry Early III (Minnesota), 11-7
Third Round: lost to #4 Mitch Minotti (Lehigh), 2-0
157 – Brooks Martino
First Round: Bye
Second Round: lost to #5 Dylan Cottrell (West Virginia), 4-1
Consolation Second Round: Advanced via medical forfeit
Consolation Third Round: Advanced via medical forfeit
165 – Ray Bethea
First Round: Bye
Second Round: def. Christian Maroni (Gardner-Webb), 5-2
Third Round: lost to #1 Alex Dieringer (Oklahoma State), 20-0
174 - #10 Casey Kent
First Round: def. Alex Schenk (Duke), 4-0
Second Round: def. Barnett Walthall (UT-Chattanooga), 10-4
Third Round: def. #7 Ben Stroh (Wyoming), 12-0
184 - #3 Lorenzo Thomas
First Round: Bye
Second Round: def. Anthony McLaughlin (Air Force), 9-1
Third Round: def. Garret Krohn (Stanford), 5-2
184 – Joe Heyob
First Round: lost to Hunter Gamble (Gardner-Webb), 7-4
Consolation First Round: def. Samson Imonode (Army West Point), 4-3
Consolation Second Round: def. Robert Stevenson (Minnesota), 15-4
197 – Frank Mattiace
First Round: Bye
Second Round: def. Jacob Cooper (Michigan State), 11-2
Third Round: lost to #2 Conner Hartmann (Duke), 5-1
285 – Patrik Garren
First Round: def. Connor Tolley (UT-Chattanooga), 6-4
Second Round: lost to #5 Riley Shaw (Cleveland State), 5-3
Consolation Third Round: lost to Boyce Cornwell (Gardner Webb), 12-2
The Southern Scuffle resumes on January 2 with quarterfinals at 9 a.m.


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Produce Explainer: Freestone Versus Cling Peaches
On the left, a freestone peach; on the right, a sliced and man-handled clingstone peach
Katherine Spiers
There are many varieties of peaches in the world today. But since all the commercially available peaches are more or less delicious, consumers only need to know one thing about any peach they might buy: Is it freestone or cling?
The names explain themselves. With freestone peaches, when sliced, the fruit easily separates from the pit, or the stone. Cling (sometimes called clingstone) can be sliced around the pit, but when you try to gently twist the fruit, you end up mangling it till it's mush. A very sad and sticky situation.
Unless your superpower is the ability to identify different varieties of fruit on sight (which would make you pretty cool, and/or a farmer), it's difficult to know whether a given peach is freestone or cling. Cling peaches often are reserved for canning and jamming, but the whole fruit makes it to market, too. Generally speaking, cling peaches are harvested earlier in the season, with freestones getting ripe later in the summer.
There are some peaches marketed as "semi-cling," but those are a lie. Do not expect to get clean slices from those peaches.
There is no difference in taste between the two types of peaches, just ease of use. Either option is great if you're eating out of hand. But if you have loftier goals, check the signage at the supermarket (they sometimes will have this information listed) or ask at the farmers market. In the process, maybe you'll figure out which peach varieties are your favorites, which would make you a superhero.
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Follow Along
We encourage you to take notes using an app on your smartphone or tablet. Our team likes YouVersion, Evernote, Day One, and Simplenote.
Our Calling: No matter where you work or what you do,
- Work with God
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Every experience is an opportunity to reveal Jesus in the way I relate.
Helpful Resources:
Two of the books that have helped with this message are Tim Keller's Every Good Endeavor and Bob Buford's Halftime
Men's Breakfast
APR 16 at 7:30 AM | Men of Southeast, wake up a little early on a Saturday and start growing with other guys. Connect with men you already know, or make some new friends over breakfast with a great lesson.
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Brave: Single Moms Event
APR 30 at 9 AM | Brave: giving all our hearts so God can make us whole, is an event for single moms. This day is all about supporting and encouraging you. Come join us as we honor you and your journey as a single mom.
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APR 30 – MAY 1 | Scoring high on the cuteness meter, Kids Choir is a favorite Southeast tradition. Kids in 1st-6th grade are invited to be a part of Kids Choir. Participants must be available for all rehearsals, warm-ups, and services.
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AUG 27 | Mark your calendars for August 27 and be a part of this year's Love Where We Live one day service project. This is a great way for people of all ages to serve our community in practical and important ways. You don't want to miss it!
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Updated on 09/16/2011 9:21AM
U.S. buyers get Ballingarry
Ballingarry, the winner of Sunday's Canadian International at Woodbine, has been acquired by a partnership headed by Sidney Port and now will be trained by Laura de Seroux, the trainer said Tuesday.
De Seroux said Ballingarry will be pointed to the $2 million Breeders' Cup Turf on Oct. 26 at Arlington Park. Ballingarry, however, will have to return to Europe before heading back to the United States for the Breeders' Cup. According to de Seroux, Ballingarry only completed the necessary equine health tests for an abbreviated stay in North America, not the more extensive tests required of a horse who staying permanently. Those tests will be completed by the time Ballingarry returns for the Breeders' Cup.
Jeff Fort, an assistant to de Seroux, and Etienne Drion were scheduled to head to Toronto in order to accompany Ballingarry on his flight on Thursday, and will remain with the colt until he heads back for the Breeders' Cup, de Seroux said. Ballingarry will go to France, and be housed at the yard of trainer John Hammond.
"He'll go on our routine," de Seroux said. "He'll just have some light canters. We'll freshen him up for this race, and after the Breeders' Cup he'll get a long break."
According to de Seroux, the deal, negotiated by her husband, bloodstock agent Emmanuel de Seroux, had been agreed to in principle before Sunday's race. On Monday night, Dr. Greg Ferraro, a veterinarian, flew to Toronto and examined the 3-year-old colt Tuesday morning at Woodbine.
"It's a done deal. He passed the vet with flying colors," de Seroux said from her stable at the San Luis Rey Downs training center in Bonsall, Calif.
Port, a 91-year-old retired Chicago businessman, will be the majority owner, with the de Serouxs and Marsha Naify also sharing ownership. De Seroux said the sales price was "seven figures," but she declined to be more specific.
Ballingarry, who was based in Ireland, had been owned by Susan Magnier and trained by Aidan O'Brien. Ballingarry, a son of Sadler's Wells, finished third in the Irish St. Leger, his race before the Canadian International. He was considered a cut below such highly regarded O'Brien-trained 3-year-olds as Hawk Wing and High Chaparral and thus was on the market.
"It shows how strong Coolmore is," de Seroux said, referring to the outfit run by O'Brien and owners Michael Tabor and John Magnier, Susan's husband.


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BP Comment Quick Links
April 29, 2010
Future Shock Blog
Minor League Update: Games of April 28
Things Change Quickly
Chris Tillman, RHP, Orioles (Triple-A Norfolk)
Wednesday's stats: 9 IP, 0 H, 0 R, 1 BB, 6 K
Three days ago I speculated as to whether or not red-hot Jake Arrieta would get the next call to the big leagues as opposed to Tillman, who made 12 big league starts last year but began 2010 in the minors. Forget I said anything as Tillman delivered Norfolk's first no-hitter since 1992, sitting at 90-94 mph with his fastball and generating plenty of bad swings from his plus curve. A fifth inning walk was the only blemish on his record, and he looks big league ready . . . just like Arrieta. Patience, Baltimore fans, patience.
Proving To Be Human
Aroldis Chapman, LHP Reds (Triple-A Louisville)
Wednesday's stats: 6 IP, 5 H, 3 R (2 ER), 2 BB, 4 K
Like Stephen Strasburg, Chapman has the spotlight on him every time out. Unlike Strasburg, reasonable expectations for Chapman involved some very real growing pains. While Chapman delivered the first quality start of his young career while throwing a season-high in innings and pitches (99), there was some sloppiness associated with the outing, as he gave up the first two home runs of his nascent career while once again having occasional command issues. The fact that he can deliver this kind of outing on an "off" night is a tribute to his talent, and he's still on pace for a big league look towards the end of the year.
Maybe Last Year Was For Real After All
Carlos Peguero, OF, Mariners (Double-A West Tenn)
Wednesday's stats: 4-for-5, 3 HR (9), 3 R, 4 RBI, CS
Peguero hit .271/.335/.560 last year, but that didn't get him much attention as a prospect. See, last year Peguero played at High Desert, the most inflated offensive environment, and where 19 of his 31 home runs occurred, to go with a .679 slugging percentage, compared to a .449 mark on the road. Then there was the 172 strikeouts as well to give cause for concern. The Double-A Southern League was expected to be something between a test and a wake-up call for Peguero, and instead, the 23-year-old Dominican is now tied with Mike Stanton for the minor league lead in home runs after last night's three bombs. Between the numbers and some impressive early reports from scouts, he's already improved his stock considerably, and everyone knows that Seattle is desperate for some power sources.
More Good News For Mets Fans
Zach Lutz, 3B, Mets (Double-A Binghamton)
Wednesday's stats: 3-for-3, 2B, HR (6), 3 R, 3 RBI, BB
It's been a good April for the Mets, at both the big league and the minor league level. A fifth-round pick in 2007, Lutz was a massive star at Alvernia College, a small Division-III school in Pennsylvania, but a broken foot limited him to just 25 games in his first two seasons. Finally healthy, he had a good year in the Florida State League in 2009, and this year has been nothing short of an explosion, as he leads the Eastern League in home runs and total bases, while sitting in the top three in on-base percentage and slugging. He'll never replace David Wright at third base in New York, and he's not very good there anyway, leaving most to believe he''ll end up at first. That's Ike Davis territory, so Lutz' future might be bright, but it's probably not going to happen in the Big Apple.
Running Like It's The 1980s Again
Mike Trout, OF, Angels (Low-A Cedar Rapids)
Wednesday's stats: 3-for-4, 2B, 3B, 2 R, SB, K
Born in 1991, the Angels first-round pick from last June wasn't even alive back when stolen bases were a much bigger part of baseball, but he's doing his best to help bring speed back to baseball, with nine stolen bases in his last ten games and an overall line of .372/.432/.474. He doesn't look like a traditional leadoff man at nearly 220 pounds, but the plus-plus speed is very real, and scouts think there's going to be power down the road as well.
Sleeper Alert!
Bruce Pugh, RHP, Twins (High-A Fort Myers)
Wednesday's stats: 7 IP, 4 H, 0 R, 1 BB, 12 K
A 19th-round pick in 2008, Pugh was a relative unknown last year, but he opened the eyes of scouts by showing 94 mph heat out of the Low-A Beloit bullpen while striking out 99 in 85 innings, mostly out of the bullpen. His secondary stuff still needs plenty of work, so most think he'll move back to a relief role as he advances, but he delivered the best game of his pro career Wednesday, whiffing 12 of the 25 batters he faced. Not a huge prospect, but for a 19th-rounder, he's a good find for a team that often sets the standard for scouting and player development.
Others Of Note:
Kevin Goldstein is an author of Baseball Prospectus.
8 comments have been left for this article.
BP Comment Quick Links
Apr 29, 2010 10:24 AM
Jim Humdingding
Kevin, how soon can you start believing in what Neil Walker is doing? I check his spring numbers just for giggles, and he hit .333/.474/.533 with a 4/4 K/BB in 15 ABs. So, he's at 90 ABs (spring + AAA) drawing walks and showing unusual, for him, plate discipline. I'd like to believe, but I'm suspicious.
Apr 29, 2010 10:50 AM
to expand, at what point is he a better choice to be called up over Steve Pearce?
Apr 29, 2010 11:03 AM
Brian Kopec
#1. Don't believe the 90 at bats.
Apr 29, 2010 12:08 PM
kevin, no mention of austin romine? so far he has been showing those signs of improvement you thought he needed to show with a .333/.412/.467 8/12 BB/K line and he leads the EL in 2B's. he is hitting .432/.512/.622 the last 10 games
Apr 29, 2010 12:55 PM
Brian Cartwright
Dustin Ackley is still good and Neil Walker still sucks.
Apr 29, 2010 17:01 PM
Any thoughts on Brandon Belt? He's putting up silly numbers for the SJ Giants (.443/.532/.705). He has a .440 BABIP, but when you assume a BABIP regression to reasonable levels his numbers will still be good. Also, 21% line drive rate and...get this...4:12 K:BB ratio in 77 PA's.
Apr 30, 2010 03:44 AM
Patience is being sorely tested in Baltimore.
Apr 30, 2010 10:39 AM
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VTDL Admissions Procedure
Applicants who reside in the following state cannot be considered for admission to the Veterinary Technology Distance Learning Program: Kentucky.
Purdue does not have a current distance education state authorization agreement with these states and cannot admit students who reside in these locations to a Purdue distance program at this time.
This exception does not apply to Purdue's on-campus Veterinary Technology program.
Admissions ProcessAdmission applications may be submitted at anytime during the year. Classes begin in January, June and August and it is strongly recommended that you apply early. All required documents for the admissions application must be in the Office of Admissions prior to the first day of classes for the semester you wish to begin. Any missing documents may require that your admission be delayed for a semester.
Print these directions for reference.
Click http://admissions.purdue.edu/apply/apply.php to proceed to the Admission webpage and complete an on-line application for Veterinary Technology Distance Learning.
1. Click on "All Other Students" box.
2. Scroll to the bottom of the page, and click on "First time user account creation". Create a login and PIN. Reember this number so you can check your admissions status at a later date.
3. Log into system.
4. Choose option: "Veterinary Technology Distance Learning Students"
5. Complete the required information and submit the on-line application and any fees.
6. All high school and college transcripts should be submitted directly to the Office of Admissions following completion of the on-line admission application.
7. The Office of Admissions will evaluate your Application and transcripts, and will notify you of your acceptance or non-acceptance.
Contact the Office of Admissions with any questions.


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Farmgirl's Easy Cut Cookies
Recipe by GirlwithMS
Easy cut out cookies with a twist: whole wheat flour, almond meal and eggwhites. Light and tasty, easy to decorate.
Top Review by yogiclarebear
I'm so excited to have found a cut out cookie recpie with no white flour. This was very good! I also used the 1/2 cup sugar and Stevia substitute, as per another review. I measure my ingredents by weight, and found that I had to add a bit more flour to get these to work, but they turned out great! I also used reduced fat margarine.
See Discussion:2 Reviews
Ingredients Nutrition
- 1⁄2 cup butter
- 3⁄4 cup sugar
- 1 egg white
- 2 teaspoons vanilla
- 1 1⁄2 cups whole wheat pastry flour
- 1⁄2 cup almond meal
- 1⁄4 teaspoon baking soda
- 1⁄2 teaspoon salt
Directions See How It's Made
- mix butter and sugar.
- add egg white and vanilla.
- mix dry ingredrients, add to wet.
- wrap in plastic and chill for 30 minutes or more.
- preheat oven 350.
- sprinkle flour on board and rolling pen.
- roll out dough and cut with shapes.
- cook on greased sheets for 10-12 minutes.
- cool on cookie sheet.
- decorate as desired.


text:
- This letter announces a price increase, so use a soft tone. Justify this change and appreciate the client's understanding while giving this unwelcome news. Tell the customer that you had to take this step but customer satisfaction is important to you.
- Deliver the news of the price increase in a soft tone.
- Appreciate the customer's understanding.
[Address line]
[State, ZIP Code]
[Letter Date]
[Address line]
[State, ZIP Code]
[Subject: Normally bold, summarizes the intention of the letter] -Optional-
Dear [Recipients Name],
To my valued clients:
I hope that you have found that the last two years of your continuing patronage have been very beneficial for the both of us.
Due to the substantial increase over several years of office, supply, and labor expenses, I have found it necessary to increase my hourly rate. Although I would very much like to retain my current rates, I have found that increasing my rates would allow me to continue and improve my legal services for you. Starting April 1 this year, my rate per hour would increase to $200.
I look forward to your continuing patronage. Calls on concerns regarding this matter shall be most welcomed.
[Senders Name]
[Senders Title] -Optional-
[Enclosures: number] - Optional -
cc: [Name of copy recipient] - Optional -


text:
So I was walking back to school from a take away with a male friend this morning and at some point he was like: 'apparently that girl also thinks you are not wearing a lot' (me wearing a short black sundress and some heels (we discussed how I was wearing hardly anything before)) and we then came to the subject of why she did that, him insisting she was jealous, do you think that's true?
Do you think girls are jealous of me?
Have an opinion?
What Guys Said 14
there is no possible way of me knowing but... possibly?00|00|0
They are prob jealous of you, Haters are going to hate00|00|0
Could be a little bit.00|00|0
Girls always find a way to hate and be jealous of each other00|00|0
I have heard that girls in school tend to be more jealous/aware of each other... but maybe yes? maybe no?00|00|0
Ok nice picture, is that the purpose of your question?00|00|0
Yes because I truly do not believe they are
You look nice so they could be00|00|0
I doubt that girls in general are jealous but, I'm sure there's at least one?00|00|0
Haters gonna hate.00|00|0
possibly. well if they are, you cannot control what they do, but then it's not your fault.00|00|0
People have a reason to be jealous your absolutely stunning :)00|00|0
Thank you
As far as beauty is concern my answer is no. answer may be yes if they are more ugly then you. As far as brain is concern if you have good knowledge yes. or else not.00|00|0
yes so much so00|00|0
what's there to be jealous of? not exactly stunning so might be your personality?11|00|0
That's what I meant
What Girls Said 5
You're gorgeous. I'm jealous. So yes, she may like the boy or just jealous of your body and how damon pretty you are00|00|0
Thank you. You have no reason to be jealous though, I am not that pretty and you are gorgeous.
She could have been jealous. If so just ignore because you look cute ^^10|10|0
I thought you were wearing a robe and a nightgown, so I don't know.00|00|0
Just what my mom said this morning I see she might have a point calling my dress a négligé
They may have thought that. I don't know girls are so mean to each other so they could be jealous, idk?
Me neither
I see nothing to be jealous of hahaha00|00|0
You are almost funny but oh wait no you posted anonymous
Because I don't want you to be jealous of me, duh.
Oh ok I'm sorry but I think the only thing you have to be jealous of is your crappy sense of humor and the fact that you are a wimp
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text:
Clue: Get a wife
We have 2 answers for the clue Get a wife. See the results below.
Possible Answers:
Related Clues:
- Tie the knot
- Combine
- Married
- Get spliced
- Amalgamate
- Have an "altar-cation"?
- Exchange I do's
- United
- Take the plunge, so to speak
- Fuse
Last Seen In:
- New York Sun - May 09, 2006
- New York Times - July 17, 2002
Found an answer for the clue Get a wife that we don't have? Then please submit it to us so we can make the clue database even better!