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Peto's paradox stipulates that there is no association between body mass (a surrogate of number of cells and longevity) and cancer prevalence in wildlife species. Resolving this paradox is a very promising research direction to understand mechanisms of cancer resistance. As of present, research has been focused on the consequences of these evolutionary pressures rather than of their causes.
Here, we argue that evolution through natural selection may have shaped mechanisms of cancer resistance in wildlife species and that this can result in a threshold in body mass above which oncogenic and tumor suppressive mechanisms should be increasingly purified and positively selected, respectively.
We conclude that assessing wildlife species in their natural ecosystems, especially through theoretical modeling, is the most promising way to understand how evolutionary processes can favor one or the other pathway. This will provide important insights into mechanisms of cancer resistance.
One of the challenges to multicellular organisms is the deregulation of the cooperative interactions between component cells that natural selection has taken long periods to produce. Cancer is one large class of such multicellular deregulation often resulting in death [1], and poses the puzzle of how or whether it is opposed by natural selection. Although assessing natural selection in human populations is challenging, indications of how natural selection may have moulded human cancer incidence can be assessed by comparing incidences of cancers in wildlife species [2]. Specifically, we need to understand the mechanisms underlying the so-called "Peto's paradox"—the absence of a correlation across species between cancer and body size or longevity [2,3], Figure1. If each dividing cell in a multicellular organism has the same probability of initiating a malignant neoplasm, then all else being equal, the more cells an organism has, the greater the chance of cancer emerging. Thus, blue whales which, at adulthood, may weigh more than 100 metric tons, should be at least 1000 times more likely to develop a cancer than humans. Moreover, transitions to malignancy are expected to increase with the number of cell divisions—that is with organism life-span. Numerous studies have shown correlations between longevity and body size, making Peto's paradox all the more difficult to resolve [2]. How do large, long-lived species overcome the burden of cancer? We [2] hypothesized that organisms evolving large body sizes and long life spans, concomitantly evolved mechanisms to offset increased cancer risk. These may include slower somatic cell turnover, redundancy of tumor suppressor genes, more efficient immune systems, better suppression of inflammation or resistance to oncogenic viruses. Currently, no clear consensus has emerged about which of these mechanisms, if any, are the products of natural selection. It is therefore crucial to focus more attention on the evolutionary causes of Peto's paradox.
Here, we propose that oncogenic or tumor suppressive mechanisms should be increasingly purified or positively selected, respectively, above a given threshold in body mass (Figure1). There is correlative evidence for a within-species increase in cancer frequency with body mass [4]. For instance, cohort studies in humans have shown that leg lengths 3-4mm above the average is associated with a 80% higher risk of non-smoking cancers (Figure1; reference 4, but see 5). Despite the prediction that more cells in a body should be associated with a higher probability of cancer, current knowledge indicates that cancers do not increase across wildlife species as a function of body mass (incidences are typically between 20 and 40%, 2).
We suggest that these contrasting patterns are produced by large wildlife species undergoing stronger selection against cell deregulation and for tumor suppression than smaller ones. Analyzing the selective pressures within a species' ecosystem (i.e., biotic and a biotic environments) will inform if natural selection targets oncogenic and/or tumor suppressive mechanisms. Identifying patterns across species in cancer resistance evolution would be an important insight into resolving Peto's paradox.
We need to understand the selective (biotic and a biotic) landscapes in which species evolved and continue to evolve. Indeed, natural selection is the product of how environments favor specific heritable phenotypes. Cancer vulnerability amongst wildlife species is likely to have been shaped by natural selection, depending on which fitness-reducing risks predominate (somatic diseases including cancer, infectious and parasitic diseases, predation and adverse environmental conditions). For instance, small rodents in natura may succumb to cancer, but only if they do not first die from any one of numerous other causes, such as predators, infectious diseases, or environmental vagaries such as floods, temperature extremes, etc. Natural selection will tend to promote resistance to sources of mortality prior to reproduction, meaning that for blue whales to grow so large and live so long, they need to both develop defenses against predators and resistance to somatic diseases like cancer. There is clearly a chicken-and-egg problem here, since changes in body size, longevity and life history strategy will alter the selective influence of different mortality factors, including the probability of cancer emergence.
Studying this complexity (i.e., numerous environmental factors acting and interacting in opposite directions and/or with reciprocal effects (Figure2)) requires the development of a theoretical approach. Adopting a quantitative framework, such as adaptive dynamics [5], widely applied to understanding the evolution of pathogens and life-history traits, can help understand how different biotic and a biotic selective pressures affect trait evolution and especially those involved in cancer protection.
Since wildlife species are subjected to a large variety of selective pressures and are found in a diverse range of habitats, it should be possible to use comparative genomics [6] to understand how proto-oncogenes and TSGs covary with certain environmental characteristics. Indeed, comparing genomic regions of interest for cancer research, e.g., proto-oncogenes or Tumor Suppressor Genes widespread in mammals, according to the biotic and a biotic environments where these species are found can give important insights into how these classes of genes have been shaped by natural selection as a function of the environment.
Addressing these considerations is undoubtedly relevant for human populations living in different environmental conditions (e.g., presence or absence of pathogens). Indeed, evidence suggests that many human populations lack alleles with enhanced protection against certain cancers, possibly because their short life-spans have precluded selection for those alleles [4,7,8].
Given the complex nature of interactions arbitrating cancer (Figure2), mathematical and statistical approaches will be necessary to tease apart causal mechanisms and their interactions [9-19], especially for the optimal use of chemotherapies [20]. In particular, quantitative approaches will help understand the selective forces acting on oncogene dynamics in animals in nature. Although cancer is an important cause of morbidity and mortality in several wildlife species [21], data are difficult to collect because most wild animals live and die unseen [21]. In this context, quantitative approaches will be of considerable interest to understand and predict wildlife cancers, and to see to what extent insights can instruct on the prevention of cancer in humans.
The authors declare that they have no competing interests.
BR, MEH and FT conceived the study, BR, MEH, AFC, CCM RAG, DM, and FT wrote the manuscript. All authors read and approved the final manuscript.
The pre-publication history for this paper can be accessed here:
This work is a contribution from the "Centre de Recherche Ecologique et Evolutive sur le Cancer" (CREEC) and the PEPii program funded by the CNRS. BR, MEH and FT thank the RNSC (Réseau National des Systèmes Complexes) for financial support.
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


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Expanding on the previous post, let's talk about entire potential kits; I feel this'd work better than looking at individual potential abilities.
Disruptive AP Caster
Kit designed to lane purely on outplays. Shuts down key targets in team fights. Rewards success and punishes failure harshly on both sides.
- Squishy, ranged APC with support potential.
- Passive: Borrowed Time: Decreases the cooldown of your spells by 1 second whenever a nearby foe uses a spell, but increases the cooldown of your other spells (if they are already on cooldown) by one second whenever you use a spell. Gain a small amount of mana whenever your cooldowns are reduced by this passive.
- Q (Active): Backfire: Foe-targeted debuff. Deals relatively small damage and applies a debuff to target foe for a very short duration; if they attempt to use a spell during that duration, it fails, that foe takes additional damage, and that spell goes on a short cooldown.
- Instant. High-ish cost, cooldown to match average poke, and mid-range.
- W (Active): Oblivion: Foe-targeted debuff. Applies a debuff to target foe for a few seconds; the next time that that foe casts a spell while debuffed, that spell's cooldown is multiplied and your spells' cooldowns are decreased proportionally.
- Longish cast time. Quite expensive, longish cooldown, and longish range.
- E (Active): Mana Burn: Large, ground-targeted debuff. Applies a debuff to targeted units, dealing mediocre damage over time that increases over the duration. You gain mana based on the damage dealt. If a champion is affected, you gain significantly more mana and they lose a similar amount; however, the effect ends if they use a spell. Quite expensive, but pays for itself and then some if used in the right circumstances.
- Longish cast time. Cooldown and range to match average poke.
- R (Active): Panic: Large, ground-targeted debuff. Applies a debuff for a few seconds to all foes affected; whenever one of those foes uses a spell, deals a small amount of damage to other nearby foes (not the caster) and silences them for a short duration. Deals the same damage on autoattacks, but does not apply silence.
- Short cast time. Expensive, but not prohibitively so, with a longish cooldown and range.
High-skillcap AP Melee Mage
Get ready for some heavy reading, because this concept isn't "easy". In the interest of speeding the process along, I'll put the whole thing in easy terms up-front:
Q drops an arrow on the ground after a very small delay (like a Syndra Q); stepping on that arrow shoots a unit in the direction that it's pointing, destroying that arrow in the process. Anyone can step on arrows, for or ally, champion or minion, and the caster can decide where the arrows point on when they cast them. If things hit other things due to the arrow launch, damage happens, but not to allies; it can also be a wallbang.
W passively gives on-hit bonus damage every 3rd hit (like Vayne, Vi, or kind of Diana), except that last hit is also a knockback (instantly drops a Q arrow directly under the foe; no delay). W also has an active component, which can be cast on self or an ally (like Nami's W), which gives bonus attack speed and 3 empowered AAs, with each charged AA dealing bonus magic damage. If all three attacks hit the same thing, it deals even more magic damage and drops its Q arrow under the target, just like the passive. The passive is lost while on CD.
E passively gives this champ a shield when they're launched by a Q arrow. Whenever this champ is launched by anything, though (like Q, or a Lee kick, or Flay, or Moonfall), they can use E actively to stop that launch immediately and gain a charge; they can use the charges to activate a dash, which also gives a shield (kind of like Riven's Valor). As long as the shield is up, it helps to stick to runners or to escape pursuers, but not much.
R makes the arrows from Q (and W, since it's a Q arrow) shoot in the direction they're pointing; they do damage on impact, and also have all the same knockback rules as Q, so they can potentially do even more damage by making stuff hit other stuff. When the arrows are shooting, though, they can't affect allies.
That's the simple version; here's the more detailed version:
- Relatively beefy (for an AP Caster) largely-AA-based melee mage with support potential.
- Passive:
- Q (Active): Vector Arrow: Ground-targeted vector "skillshot". Places a mark at the vector's initial location that lasts for a few seconds, pointing visibly in the vector's direction; when stepped on the unit that activated it will be instantly accelerated in the direction of the vector, with their speed decaying over the duration of the launch. The mark is consumed after triggering once.
- On ally/self trigger: you or that ally deals AP-based magic damage on collision with foes; if you or an ally passes over a mark while being launched in its opposite direction, that mark shatters, causing you to lose a charge and stopping you/that ally's movement immediately.
- On foe trigger: foes stepping on the mark are launched in the direction of the vector, taking damage on collision with, dealing less damage to, and knocking aside other foes they strike; on collision with terrain, that foe takes damage and is stunned for a short duration; if a foe passes over a mark while being launched in its opposite direction, that mark shatters, instead, dealing significant AP-based damage and rooting the foe that triggered it.
- If a vector direction is not definitively specified on cast, it "intelligently" orients itself (ala Draven axes); I'll even include the recommended behavior:
- Consider four "zones" around and between the ally and foe nearest the target location: the space closest to the ally, both toward and away from the foe, and the space closest to the foe, both toward and away from the ally. We'll call them "ally in" (1), "ally out" (2), "foe in" (3), and "foe out" (4), respectively.
- In the most complicated case, both the ally and foe are attacking each other; in this case, the vector mark should point directly toward the foe if in zone 1 (ally wants to engage), away from the foe if in zone 2 (ally wants to disengage), away from the ally if in zone 3 (foe wants to engage), and directly toward the ally if in zone 4 (foe wants to disengage).
- If the ally is chasing/attacking a fleeing foe, the mark should point directly toward the foe if in zone 1 or 3 (ally wants to engage), directly toward the ally if in zone 4 (foe wants to disengage); it should point directly away from the foe if in zone 2 (ally has changed their mind and now wants to disengage).
- If the ally is fleeing a chasing/attacking foe, the mark should point directly away from the ally if if zone 1 or 3 (foe wants to engage), directly away from the foe if in zone 2 (ally wants to disengage); it should point directly toward the ally if in zone 4 (foe has changed their mind and now wants to disengage).
- If there are no visible foes nearby, non-targeted should point directly away from the nearest ally if placed in front of them (speeds them in a direction) and directly toward them if placed behind them (helps allies to group).
- There may be additional cases that I haven't considered, but I think that the fact that you can, in fact, manually orient the vectors ought to solve most problems. I know what you're thinking: "But wait, then why have auto-targeting to begin with?": simple answer is "because you have other things to do". You're a melee mage; when you're going in with W and want to place a mark behind your foe so you can proc the damage/CC with your last W charge, you don't have time to be lining up arrows; you're meleeing. It's a QOL thing.
- No cast time, but with a short, visible delay before the mark is active. Uses a charge system, with a few able to be stored at once and a relatively low cooldown between charges; low mana cost, longish range.
- W (Passive): Vector Blade: After three consecutive autoattacks on the same foe, deal bonus AP-based damage and create a Q mark at that foe's location, pointing directly away from you; the mark triggers immediately unless that foe was killed by your autoattack. Passive is lost while on cooldown.
- W (Active): Vector Blade: Ally-targeted buff. On cast, instantly place a Q vector at target ally's location, pointing in the direction they are currently facing. Empowers target ally's weapon for a few seconds, granting them bonus attack speed and causing their attacks to deal bonus magic damage based on your AP; lasts for 3 hits. If all three hits strike the same target, the final strike deals additional magic damage and creates a Q vector at the location of the struck foe, pointing directly away from the targeted ally; the mark triggers immediately unless that foe was killed by your ally's autoattack.
- Instant. Relatively expensive, medium-long cooldown.
- E (Passive): Momentum Shield: While dashing from activating a Q mark (including from W), gain a small absorption shield based on your AP that decays to nothing over time, ending completely one second after the dash ends.
- E (Active 1): Halt Inertia: If you were in the middle of any forced movement (including from a Q mark or Dark Passage), end that movement immediately and gain one charge for this ability, up to 3 max. The passive shield fully dissipates over the next second, regardless of how much of it remained on activation.
- Instant activation. Moderate-ish cost; short cooldown. Notably, cannot be used while stunned, so precludes stopping Thresh and Blitz pulls (unless you have Cleanse or QSS, but then that's still clutch as fuck; I can't even be mad at that).
- E (Active 2): Renew Inertia: Consume one charge to gain a substantial absorption shield for a few seconds and dash a short distance toward the cursor. While this shield persists, your attacks draw you and your target together a short distance and attacks against you push you and your attacker apart a short distance.
- Instant activation, relatively fast dash. No cost, no cooldown. Pull/push distance is very small; the combined effect should be less beneficial than Frozen Mallet for stick/peel. Of note, E can't be used to stop an E, since it's not a forced action.
- R (Active): Vector Storm: Non-targeted spell. Causes all currently-placed marks from Q to change into collision linear skillshots that fire rapidly in the direction they are pointing, dealing significant damage to and knocking foes in their direction, according to the rules of Q, exactly as if they'd stepped on the marks. Marks do not affect allies while in this state.
- No cast time, but with a visible delay before actually activating. Medium-short cooldown, medium-low mana cost.
High-skillcap AD Assassin
- Squishy melee AD assassin/carry.
- Passive:
- Q (Active): Knives from the Shadows: Narrow cone/wide line of linear collision skillshots. Deals moderate AD-based damage; deals bonus damage to and roots foes that are not visible. Can critically strike.
- Cast time scales with your attack speed. Relatively spammable, with low mana cost and cooldown. Decent range.
- W (Toggle): One With Shadow: Self-buff. Enter stealth, but lose vision of enemy units (ala Paranoia) outside of the immediate area. Using an ability temporarily breaks stealth (does not restore your own vision), but you gain a significant burst of movement speed whenever you enter stealth. While toggled on, Q's cost and cooldown are reduced by a significant amount, but its root effect is replaced with a slow.
- Costs a bit of mana on activation and also a small amount per second.
- E (Active): Blade in the Dark: Linear passthrough ground-targeted dash. Dash to target location, dealing strong damage to and stunning all foes you pass through. The damage, range, and stun duration of this ability are increased based on how long you were stealthed for before using it, up to a cap. If using this ability while stealthed, you are revealed for the cast time, but your stealth is not truly broken until the dash completes, at which point you gain bonus attack speed for a short duration.
- Short but noteworthy cast time; medium-long base range; relatively expensive with a moderate cooldown.
- R (Active): The Stuff of Nightmares: Self-centered area effect. Remove nearby allies' and foes' vision of units outside the immediate area for a short duration. During this time, the presence of any champions in the affected area is revealed to you (you do not gain true vision of them; they are only marked to say "a champion is here"), and using an ability only reveals you to any foes struck by that ability. You gain massively increased movement and attack speed for the duration.
- Moderate but not prohibitive cost; longish cooldown.

subset: commoncrawl


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Eamon Flack took over as the Artistic Director of Belvoir Theatre Company in late 2015, making him the third Artistic Director in the company's history. 2016 will see his first programmed season for the company. As an actor, director and dramaturg he's worked for Belvoir, Melbourne Theatre Company, Malthouse Theatre, Bell Shakespeare's Mind's Eye, Perth International Arts Festival, Darwin Festival, Playwriting Australia among others. His most recent production is "Ivanov", adapted by Flack from the Chekhov play and directed by him. It's on now in Sydney until October 1.
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Mothers and Others May 06 2014
As we were talking today around the lunch room, we were discussing the strong female figures in our lives. Our mothers, but also, female friends, aunts, neighbors - we often find ourselves asking them for advice or thinking about what they would do in a particular situation. Although close relationships with moms are important, so are those relationships with other strong females in our world. They can give us support and advice that may be a different view than our mothers. We have learned that this advice and reference is critical to our growth as women, just as our mothers and grandmothers before us. On Mother's Day, we should thank and hug those women who help shape who we are everyday - as well as, our mothers - in this world or in spirit.


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Submission dowload error: not able to download upload filesAsked by LGBT_Leaders on October 15, 2015 at 01:39 PM
I need to download the uploads on one of our forms. It keeps failing to download submissions 0-100. How can this be resolved such that I can download a folder of all the uploads on our form (they are CV uploads) as a matter of urgency?
Sorry for this inconvenience. I was able to replicate your issue. I have forward this to our back end team. They are currently working on the issue and we'll get back to you when this gets resolved.
I am also having this issue. This is now in addition to the problem we are having with Dropbox integration (mentioned here). There are many files being uploaded with our competition form and it is a major inconvenience having to download each file individually to add to Dropbox for each submission, hence why having the full download option was a quicker way for us to remedy the situation while the Dropbox issue is being looked into. However now I cannot use it.
Is there any other way to export the files, in bulk, in the meantime?
To better assist everything I have moved your response to a new thread here: http://www.jotform.com/answers/683160 where we will be replying to you shortly and raising the same to our developers for inspection.
In regards to the file downloads in bulk, I would suggest taking a look here: Downloading File Uploads in the form using DownThemAll Mozilla Firefox Extension
This is using a third party plugin on Mozilla FireFox browser, but it is something that I would suggest as a good failsafe - in case other things are not working.
Another alternative is to use our File Downloader app, but this might be a bit too technical approach in which case the above mentioned guide is a better option to look into.
To confirm, this thread has already been raised and assigned to our developer who is looking into this issue, so the above are simply 2 options that might be used to download all files. I will also raise your post in your new thread so that our developers can look into it as well.
This feature is temporarily disabled, and I have just added the necessary notification.
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Hey @LGBT_Leaders,
Feature is re-activated,
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June 28 Bible Study
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Michael Smith
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Posted: Tue Jun 30, 2009 12:55 pm
Post subject: June 28 Bible Study
I brought a question to the table this past week and after the discussion was over... i was asked to present it on here. I'd like to have your feedback as all Godly conversation is good conversation.
This question has been on my mind for quite some time and I have had a few discussions w/ multiple people in regards to What happens to the man that never hears who Christ is? It is our Christian belief that the only way to heaven is through Christ Jesus (John 14:6). I have had answers given back to me on both sides. From well he goes to hell, hes never accepted Jesus as his Savior to God will treat a person of that nature differently. In having these conversations it confuses me as I am only searching for some type of commonality between believers. In the weeks to come I have prayed, studied, talked, prayed and prayed some more on what might happen to a person that is ignorant to the concept of Jesus Christ.
First of all, I want to say that one of the first things I have come to accept is its not my decision and its completely out of my control, what happens to them, and if there is a person that no one ever reaches then it is up to God to judge that person on their Day. It is not something for me to dwell on. That being said, I like many Christians of this era, have this uncontrollable desire to find truth, and answers, to the questions that the generation preceding us was afraid to ask. So thats what Ive been doing .
First, lets take the perception of hes going to hell because he didnt accept Christ as his savior. This same person tells me that he believes in the age of accountability where a child will not be judged the same due to their lack of understanding. The same would apply to someone who is mentally handicapped. They may have heard the name of Jesus but are unable to grasp what that means. (This is not true for all people in this situation and I completely believe that there are those who have and will accept Jesus as their savior .this is just an example). My question then is this: Why, if these two situations are different from what everyone else is judged by, is the man who never hears who Jesus is not judged as a child? Think of it like this:
Ambrose said that infant baptism opens the kingdom of Heaven to them. Augustine taught in four places that baptized dead infants went to Heaven. Unbaptized ones went to Hell solely due to Adams original sin. However in Hell they received only the lightest of punishments. Having a cooler spot in the Lake of Fire does not seem like much consolation, though.
If this were true, imagine two babies who are communicating across the gulf.
1st baby to 2nd: Why are you suffering?
2nd baby: I did not ask to be created, I was not aware of anything I did wrong, I had no opportunity to turn away from God in the slightest degree. I dont understand why I am being punished. Why are you in Heaven?
1st baby: People I dimly recognized, believing what I did not know, did what I do not remember. Isnt Gods grace wonderful?
2nd baby to 1st: Yeah... Wonderful...
Does this seem fair to you? This belief is not one for the age of accountability but I think it can be related to the man who never hears the word of Christ. He is the second baby, and every person whether they accept Christ or not (because they have had the opportunity to hear) is like the first baby.
My second point of view that I want to look at is this:
It could be that those who have never heard of Jesus Christ and the gospel will be judged in a different way than those who have heard of Jesus. The Bible does not tell us specifically about what happens to those who have never heard. But it does say that Jesus is the only way to salvation (Acts 4:12). If it is possible that someone who has not heard the gospel can be saved, it must be through Jesus Christ and him alone (John 14:6). But, it could NOT be that a person who is not heard of Jesus can make it to heaven based upon being good since that would violate the scriptural teaching that no one is good (Rom. 3:10-12). On the same note, if righteousness before God can be achieved through being good, or sincere, or by following various laws, then Jesus died needlessly: "I do not nullify the grace of God; for if righteousness comes through the Law, then Christ died needlessly," (Gal. 2:21).
If all people who have NEVER heard of the gospel of Jesus Christ end up in hell, then that would be right because God would never do anything that is improper. On the other hand, if any of them end up in heaven, then it would be the right thing to do for the same reason.
The third answer to this question is a little more complex but seems to make the most sense to me. The Bible says in Luke 19:40 that, the stones will cry out. So if we look at this in its context, Jesus is telling the Pharisees that even if his disciples are made to be quiet, the good news will spread, people will hear the message, the stones will cry out. Now take this in the context of the man in the remote section of the world. We all know that God is awesome and has the power and ability to do all sorts of magnificent things. I believe that at some time during this mans life, he is going to have experiences that he just cant explain. He is going to acknowledge these experiences as theres something else going on something else out there something bigger than I. At that moment, he has taken the first step towards coming to know the LORD. From that time on, I believe it to be this mans responsibility, along with the work of the Holy Spirit, to fill his life with Godly things, day in and day out learning more about the Creator, the Great I AM. In accordance with this idea or theory I think you have to look at Jesus Christ as more than just a name, as someone you accept; and you have to think about what He was and who He was. The ideas and purposes that He was all about. I think that coming to accept Jesus as your Savior means much more than accepting a name.
Finally, I want to leave you with this illustration. Lets suppose there is a man in Thailand, a rice farmer who lives with his wife and four children in a small village several hundred miles from Bangkok. Rice farming is all he has ever known. Thats his whole life. From morning till night, year round, he works to grow enough rice to take care of his family. Hes Buddhist like his father and grandfather before him. Although he is not particularly observant, Buddhism is the only religion hes ever known.
One day that farmer gets sick and goes to the local clinic. When they cannot help him, he goes to a hospital in a larger village. Eventually he ends up in a modern hospital in Bangkok. After running some tests, the doctor comes to the farmer and says, Ive got some bad news. Youve contracted incurable cancer. Theres no treatment available that can help you. And they send him back to his village to die. It happens that during that very week, researchers at the University of Chicago discover a cure for the precise kind of cancer this man has. If he gets the cure, his life will be saved. But the man knows nothing about the researchers in Chicago and the researchers know nothing about the man in Thailand. Several weeks later, he dies. Here is the all-important question: Why did he die? Did he die because he had cancer, or because he didnt get the cure? Think about it before you answer. That poor rice farmer died because he had cancer, not because he didnt get the cure. Not getting the cure simply sealed his fate. He was dying before they discovered the cure, and he was dying after they discovered the cure. Either way, he was a dying man. He ends up dead because cancer took over his body. The cure that would have saved him simply didnt arrive in time. And in this case, it never arrived at all.
In the very same way, the whole world is dying of the cancer of sin. Some people are in very advanced stages while others will live for many more years. But all of them are ultimately terminal: The cancer of sin will kill each and every person. But a cure for sin was discovered 2000 years ago. Its called the blood of Jesus Christ. Its so powerful that it cures the cancer of sin in all its ugly forms. The sad part about this story is that even though the cure has been known for 2000 years, there are still over 2 billion people who know nothing about it. Whats worse, most of them dont even know they are terminally ill with the cancer of sin. Theyre dying, and dont know it. When they die, what will be the cause of their spiritual death? In each and every case, the great Coroner of the Universe will write on the death certificate Cancer of Sin. They dont die because theyve never heard the gospel. They die because they are sick with sin. Not hearing the gospel simply seals their fate.
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Joined: 17 Dec 2008
Posts: 186
Posted: Wed Jul 01, 2009 12:00 pm
Post subject:
This is a very important question. It is a question that confronts God's very nature.
In light of this, I don't want to be too hasty in formulating, and even sharing, my own opinion. Rather, let's go to the Word and discover what God says in regard to this matter.
As we go to God's word, we must recognize that God is eternal (not limited by space or time). We must also recognize that Jesus Christ (The Word) was responsible for creation before His physical birth. (John 1:3 "All things were made by him; and without him was not any thing made that was made.")
My suggestion is that we start by searching in scripture for verses that speak to the subject. One easy way to do this is go to blueletterbible.org
First, lets gather from God's Word, then we will look for a comprehensive answer. Our responsibility is to reconcile all verses into one perspective.
Here are a few verses on the subject:
Acts 2:21 And it shall come to pass, [that] whosoever shall call on the name of the Lord shall be saved.
Acts 4:12 Neither is there salvation in any other: for there is none other name under heaven given among men, whereby we must be saved.
Romans 10:13 For whosoever shall call upon the name of the Lord shall be saved.
John 14:6 Jesus saith unto him, I am the way, the truth, and the life: no man cometh unto the Father, but by me.
2Peter 3:9 The Lord is not slack concerning his promise, as some men count slackness; but is longsuffering to us-ward, not willing that any should perish, but that all should come to repentance.
Luke 19:40 And he answered and said unto them, I tell you that, if these should hold their peace, the stones would immediately cry out.
Galatians 3:11 But that no man is justified by the law in the sight of God, [it is] evident: for, The just shall live by faith.
John 3:16 For God so loved the world, that he gave his only begotten Son, that whosoever believeth in him should not perish, but have everlasting life.
Ephesians 2:8 For by grace are ye saved through faith; and that not of yourselves: [it is] the gift of God:
Hebrews 11: By faith Noah, when warned about things not yet seen, in holy fear built an ark to save his family. By his faith he condemned the world and became heir of the righteousness that comes by faith.
John 10:9 I am the door: by me if any man enter in, he shall be saved, and shall go in and out, and find pasture.
Romans 5:18 Therefore as by the offence of one [judgment came] upon all men to condemnation; even so by the righteousness of one [the free gift came] upon all men unto justification of life.
2Thesilonians 2:10 And with all deceivableness of unrighteousness in them that perish; because they received not the love of the truth, that they might be saved.
1Timothy 2:4 Who will have all men to be saved, and to come unto the knowledge of the truth.
1Timothy 2:5 For [there is] one God, and one mediator between God and men, the man Christ Jesus;
2Timothy 1:9 Who hath saved us, and called [us] with an holy calling, not according to our works, but according to his own purpose and grace, which was given us in Christ Jesus before the world began,
Titus 3:5 Not by works of righteousness which we have done, but according to his mercy he saved us, by the washing of regeneration, and renewing of the Holy Ghost;
John 4:36 And he that reapeth receiveth wages, and gathereth fruit unto life eternal: that both he that soweth and he that reapeth may rejoice together.
John 12:25 He that loveth his life shall lose it; and he that hateth his life in this world shall keep it unto life eternal.
Romans 1:20 For the invisible things of him from the creation of the world are clearly seen, being understood by the things that are made, [even] his eternal power and Godhead; so that they are without excuse:
Romans6:23 For the wages of sin [is] death; but the gift of God [is] eternal life through Jesus Christ our Lord.
2Corinthians 4:18 While we look not at the things which are seen, but at the things which are not seen: for the things which are seen [are] temporal; but the things which are not seen [are] eternal.
Titus 3:7 That being justified by his grace, we should be made heirs according to the hope of eternal life.
Psalms 145:13 Your kingdom is an everlasting kingdom, and your dominion endures through all generations. The Lord is faithful to all his promises and loving toward all he has made
Let's bring scripture forward before we attempt to reconcile.
Also, to summarize the question, have all men/women had equal opportunity to be united with their Creator?
Last edited by Rick on Wed Jul 01, 2009 10:19 pm; edited 1 time in total
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Joined: 05 May 2009
Posts: 7
Posted: Wed Jul 01, 2009 2:46 pm
Post subject:
I think your last question can be taken from two directions. First you can say that no, not every man/woman has had equal oppotunity. Places like the U.S. have given people many more opportunities to "hear". Not just with the internet, libraries, and media; but also with the freedom that we have in religion in this country. On the other hand, one could argue that yes, every man/woman has had the same opportunities because we are all children of God living in His created land.
I'm not sure if that makes sense... but it does in my head.
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Joined: 19 Dec 2008
Posts: 10
Posted: Thu Jul 02, 2009 3:16 pm
Post subject:
i like your "third answer" to your question in what you presented in the bible study. That's my vote for the truth
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Joined: 17 Dec 2008
Posts: 186
Posted: Thu Jul 02, 2009 10:40 pm
Post subject:
Salvation comes through one identity alone, Jesus Christ. We must give up our own (temporal) identity and take on His eternal identity. We must be born again into His spiritual ancestry.
Throughout history, identities were established not only by ancestry, but also societal contribution, thus the Baker, Miller and yes, Smith. There is an old saying pretty is as pretty does and it is from this perspective that most identities were established in the days of Christ. The Israelites were works-oriented and the relationship between work and identity was ingrained into their lives.
So who is Jesus Christ? Jesus is the divine worker. His occupational identities are Creator, Judge, Conquering King, and yes, Savior. Jesus is the fulfilled will of God the Father.
He is also ancestrally the Son of God the Father (Jehovah) and it is as a result of His claim to this divine genealogy that He was crucified. The Pharisees called Him a blasphemer, because He identified Himself as being one with Jehovah. If Jesus was not the Son of God, then he was a blasphemer and He died for His own sin. If, as we believe He is, the Son of God, then His sinless death was for our sins (the wages of sin is death).
Concerning Jesus the Savior: Was the work of the Savior eternal (omni-available)? Could one receive the benefit of the Saviors work without knowing the word Jesus? If someone was not introduced to the word Jesus, yet they trusted in the essence of that name, would they be saved? What is the essence of Jesus Christ?
Ephesians 2:8 For by grace are ye saved through faith; and that not of yourselves: [it is] the gift of God:
God identifies Himself as Love. Salvation comes by Grace through faith. Grace is Gods unmerited Love for all of mankind. God has ever extended His unmerited Love to mankind. His Love is evident in creation. The things we need most in life are most available (air, water, sunlight and the raw materials to support and sustain life).
God is life!
Death is separation from God!
God is eternal, and eternal life comes from an oneness- relationship with God.
We enter this life dead unto God.
Only by Gods love can we be one with God!
Gods love is apprehended by faith!
Gods love was lost by faith! (Eve put her faith in the words of the serpent and Adam put his faith in the words of Eve.)
So does all our knowledge help us or hinder us from an eternal relationship? Does the gospel (good news) save us, or does Jesus Christ? Is Jesus Christ Gods Grace? Could one put their faith in Gods Grace without knowing the word Jesus? And if they did, would it translate them into eternal life? Could a child, or a mentally challenged person, trust in Gods love and be saved?
I believe God gave each of us a measure of faith. Faith is a spiritual currency. Faith is to be invested in Gods love (grace). From the distant native of Africa to those that lived prior to the crucifixion, to the mentally challenged, to the over-analytical; faith can simply, or profoundly, be invested in Gods Grace. (See all of Hebrews 11)
Now back to Bangkok where the farmers cancer was identified. Did cancer begin when it was identified? Was the cancer cured because it was identified? The cure for sin (grace) must be applied by faith. Jesus is identified as the cure and the great physician. Once the cure is administered by faith, the result is eternal hope. When one discovers the source and substance of the cure (Jesus Christ) then it is received as good news. So the cure is not hindered because the patient does not know the name of the physician, or have knowledge of the ingredients within the medication. However, once the name of the physician is known, then thanks can be given.
Jesus is the only doorway into eternal life. His work of salvation (Grace) is eternal, ever available to all of mankind. Only man hinders himself from receiving Gods Grace through faith.
We must remember Christianity is not exclusive, however, Jesus Christ has an exclusive relationship with God the Father; which is ever available to all mankind.
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Joined: 17 Dec 2008
Posts: 186
Posted: Fri Jul 31, 2009 11:06 am
Post subject:
Here is another scripture which speaks to the eternal nature of Grace: 2 Timothy 1:8-11
"So do not be ashamed to testify about our Lord, or ashamed of me his prisoner. But join with me in suffering for the gospel, by the power of God, who has saved us and called us to a holy lifenot because of anything we have done but because of his own purpose and grace. This grace was given us in Christ Jesus before the beginning of time but it has now been revealed through the appearing of our Savior, Christ Jesus, who has destroyed death and has brought life and immortality to light through the gospel. And of this gospel I was appointed a herald and an apostle and a teacher."
Grace was given in Christ before the beginning of time!
We live in a "time" of revelation!
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text:
Listing ID: 7036555
Price: $899,098
Address: Lot 6 53RD ST
City: Davenport
State: Iowa
Postal Code: 52807
Acres: 10.320
County: Scott
Multiple lots in prime location along the 53rd Street corridor with utilities available at or close to property line. Lots available from 1.137 acres to 10.320 acres. Built-to-suit available for lease option, lease terms to be determined based on square footage. Contact Listing Agent for further details.
Thad DenHartog
Title: REALTOR, Director SIOR
Email: firstname.lastname@example.com
Address: 3245 E. 35th St. Ct.
City: Davenport
State/Province: IA
Zipcode: 52807
Office Phone: 563-823-5276
Office Fax: 563-344-5803
Cell Phone: 563-650-8676
Primary Features
Area: Davenport NE1/4,N of Kimberly-E
County: Scott
Flood Insurance: n
For Sale: y
Property Type: Land & Farm Property
Utilities On-site: None
Zoning: PDD
External Features
Acres: y
Approximate Lot Size: 449549 SF
Farm: n
Fenced: n
Sewer: City Sewer
Water Supply: Municipal
Location Information
Frontage And Access: Paved 2Lane, Paved 4Lane
Land Description: Level
Location: Neighborhood
Miles to Airport: 5
Miles to Highway: 1
Nearest Highway: Hwy 61
Financial Details
For Lease: y
Investment: n
Lease Information: Other Lease Info
Ownership: Individual
Sale Options: Entire Parcel
Tax Incentives: In City Limit
Tax Year: 2015
CRP: n
Easement Restrictions: Unknown
Legal Description: Call LA
Options: Build to Suit
Parcel ID Number/Tax ID: P1212-10
Potential Uses: Office, Retail
Property Type/Use: Commercial
Status Category: Active
Subdivided: y
Property Sub Type: Land & Farm Property
Three Phase: n
U.S.T.: n
Zoning Info
© 2017 Quad City Area MLS
Information deemed reliable but not guaranteed
Listing courtesy of Thad Denhartog, SIOR from Mel Foster Co. Commercial
Information deemed reliable but not guaranteed
Listing courtesy of Thad Denhartog, SIOR from Mel Foster Co. Commercial
Contact - Listing ID 7036555
Data services provided by IDX Broker


text:
-- I can fold a fitted sheet.
-- I don't really drink, I'm a light weight. :(
-- I'm honest and have a horrible poker face.
-- I have to sleep with my feet sticking out from under the covers.
-- Halloween is now my favorite holiday thanks to Halloween Horror Nights. I love being scared sh*tless!
-- I love roller coasters and theme parks in general really. Though as I age, my body does not like coasters quite as much. 15 times in a row at 15, 2 times in a row at 30...
-- Keto.
-- FL to CA to WA to FL
-- I have a "fluffy" thyroid.
-- I am not religious-- not in the slightest.
-- I have a Youtube video with over 12 million views.
-- Drawing, painting, and artsy fartsy craft stuff are my jam.
-- I make lists. For everything. And timelines. Basically, I live to plan.
-- Archery is on my To Do List. I had one lesson back in Seattle and really enjoyed it!
-- I am an ISFJ-T | "The Defender" according to http://www.16personalities.com/free-personality-test
(Introverted: 25%, Observant: 19%, Feeling: 20%, Judging: 28%, Turbulent: 39%. Role: Sentinel | Strategy: Constant Improvement)
Goody two-shoes.
Mother Hen.
What I'm looking for in a partner:
-- I prefer a more dominant *cough* personality in my partner, as I have submissive tendencies.
Not that I'm a doormat.
Nor do I sleep around despite what my profile may imply.
-- Wit. Charm. A sense of humor. Good conversation.
-- Similar values & honesty.
-- Attraction.
-- My real name is Laura, if you've actually read this all, congratulations.
In March 2012, I packed up my car with my essential possessions and drove over 2,000 miles from Florida to California where I found work as a graphic designer and social media person for an online marketing firm in LA.
Then I got tired of circling my block in Koreatown to find parking, so I packed up and moved to Seattle (October 2013).
I worked from home while contemplating going back to the 9 to 5 life. (No naps and unicorn onesies were a big deal breaker). Then my heart was broken by a guy and the city (Seattle is way too expensive).
So I found myself purging the majority of my possessions, yet again, to drive across the country back to Florida (June 2016). When did I turn into such a nomad??
Also, how has it been almost a year since I moved back? This place is a black hole! Currently, I'm missing a bigger city and I'm avidly applying to jobs in Orlando.
I'm pretty awesome at that.
I once won a game in 2 turns.
So bring it on!
So friendliness and my smile and apparently my eyes, based on recent messages.
--Neverwhere by Neil Gaiman (anything Neil Gaiman really...)
--The Last Unicorn
--Pirates of the Caribbean
--Little Miss Sunshine
--Pride and Prejudice
--The Fifth Element
--The Air I Breathe
--28 Days Later
--The Avengers
--Love Actually
--Major Payne
--The Martian
--Big Hero 6
--John Wick
--Star Wars
--The Mist
And many more...
--The 100
--Stranger Things
--The Good Place
--The Walking Dead
--Brooklyn Nine-Nine
--Orange is the New Black
--Unbreakable Kimmy Schmidt
--Jonathan Strange & Mr Norrell
Currently... Hamilton. I enjoy pretending to believe I can rap.
I love musicals and pop music, I can't say I won't sing it around you... especially if you're in a car with me.
I will give anything a chance, as long as it isn't country, gospel, hardcore rap, or hurts my ears with screaming vocals.
--Taco Salad
--String Cheese
2) Familial connection
3) Laughter
4) Friendship
5) Warmth/Love
6) Loyalty
I'm not into the partying and drinking scene. Nor can I tolerate weed, the smell bothers me, as does any smoking. Even the tiniest bit. (This was a more important side note when I lived in Seattle haha.)
But if I do go out I like to go bowling, play pool, mini golf, shopping, or driving 3 hours just to see a movie (okay that only happened once, but it was worth it!).
--You share something in common with me.
--You aren't going to be lewd or annoying.


text:
The baculovirus expression vector system (BEVS) has been successfully utilized to produce thousands of proteins for use as vaccines, therapeutics, and for structure-function studies. One limitation of BEVS is the propensity of baculoviruses to accumulate transposon insertions into the fp25k gene leading to the """"""""few polyhedra (FP)"""""""" phenotype. This mutation shifts the balance of virus production from occlusion-derived viruses, which are not infectious in tissue culture, to budded viruses, which are the form of virus that is used in baculovirus expression. These higher levels of budded virus would be advantageous for BEVS users, but FP mutants are also deficient in transcription from the polyhedrin promoter, which drives expression of target genes. Baculoviruses also rapidly accumulate defective interfering particles (DIP), which are linked to a sharp decrease in target gene expression due to deletion of the target gene and/or viral genes needed for its expression. One factor that promotes DIP formation is transposition into fp25k. The goal of this project is to develop baculovirus expression vectors that allow for manipulation of the fp25k gene. By reducing or eliminating expression of FP25K during virus amplification, we expect to obtain 5- to10- fold higher levels of budded virus titers because most of the replicative potential of the cel would go to producing budded virus instead of occlusion-derived virus. Then FP25K expression would be restored when target protein expression is desired. This would significantly lower costs for large-scale production of baculovirus-expressed proteins because high titer BV stocks would be easier to produce and the occurrence of deleterious mutations would be reduced. ParaTechs will pursue two complementary approaches to achieve this goal. One involves the production of a virus with an inducible fp25k gene that can be turned off during amplification and activated during target protein expression. The other approach utilizes a virus with a deletion in fp25k coupled with a cell line that expresses FP25K. Each of these approaches has advantages and disadvantages, both in the design phase and for the end user. Experiments described in this proposal will determine which provides higher levels of BV production, polyhedrin-linked expression, and stable genome maintenance. Ultimately, the system developed here would be combined with ParaTechs vankyrin expression technology, which increases polyhedrin-driven expression in BEVS from 2- to 20-fold.
The baculovirus expression vector system (BEVS) is commonly utilized to produce thousands of proteins for use as vaccines, therapeutics, and for structure-function studies. Unfortunately many researchers are not aware that certain mutations rapidly accumulate leading to lower levels of target gene expression. ParaTechs has developed a strategy to prevent these mutations, while simultaneously providing higher levels of virus production, stable genome maintenance, and target gene expression.


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|"Shapira, Yoav" <Yoav.Shap...@mpi.com>
|RE: [VOTE] Promote Email to Commons Proper
|Tue, 16 Nov 2004 13:36:58 GMT
Hi, Give him a couple of days to update his license and web page before we start the vote again ;) But it's sure nice to have clout when you ask people to change their license ;) Yoav Shapira http://www.yoavshapira.com >-----Original Message----- >From: Matthias Wessendorf [mailto:firstname.lastname@example.com] >Sent: Tuesday, November 16, 2004 4:08 AM >To: 'Jakarta Commons Developers List'; 'Mark Lowe' >Subject: RE: [VOTE] Promote Email to Commons Proper > >yeah Mark, > >nice deal! I also just surfed to sf.net >and figured out email-address of jasionkitchen ;-) > >so back to vote! ;-) > >-Matthias > > >--------------------------------------------------------------------- >To unsubscribe, e-mail: email@example.com >For additional commands, e-mail: email@example.com This e-mail, including any attachments, is a confidential business communication, and may contain information that is confidential, proprietary and/or privileged. This e-mail is intended only for the individual(s) to whom it is addressed, and may not be saved, copied, printed, disclosed or used by anyone else. If you are not the(an) intended recipient, please immediately delete this e-mail from your computer system and notify the sender. Thank you. --------------------------------------------------------------------- To unsubscribe, e-mail: email@example.com For additional commands, e-mail: firstname.lastname@example.com
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text:
Question: Using the methodology outlined in Exhibit 9 12 forecast the financing
Using the methodology outlined in Exhibit 9.12, forecast the financing items on next year's balance sheet for PartsCo. Assume long-term debt remains
If necessary, use short-term debt to finance cash shortfalls. Your forecast should be consistent with forecasts in Questions 2 and 3.
View Solution:
at $215 million, no external equity is raised, and no dividends are paid.
If necessary, use short-term debt to finance cash shortfalls. Your forecast should be consistent with forecasts in Questions 2 and 3.
View Solution:
Answer to relevant QuestionsThe chief financial officer of PartsCo has asked you to rerun the forecast of the company's income statement and balance sheet at a growth rate of 5 percent. If the company generates more cash than it needs, how can the ...Since growth is stable for ApparelCo, you decide to start the continuing value with year 3 economic profits (i.e., economic profits in year 3 and beyond are part of the continuing value). Using the economic profit formula ...Market betas are typically computed with five years of monthly data or two weeks of yearly data. For computational simplicity, we present only 12 data points. Using a spreadsheet regression package or other software tool, ...You are valuing DistressCo, a company struggling to hold market share. The company currently generates $120 million in revenue, but its revenue is expected to shrink to $100 million next year. Cost of sales currently equals ...Two companies have the same long-term prospects concerning growth and ROIC. One of the companies temporarily stumbles during a new product launch, and profits drop considerably as the company scrambles to fix the error.Will ...
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I'm not neccissarily chunky, but I'm 5 feet and I weight 108 pounds, so I look a little bit overweight for my size. Do guys prefer like super toned girls or is a little bit of a flubby tummy ok?
Most Helpful Guy
At your height, 108 lbs doesn't sound overweight. You have just enough softness I'll bet to make sure you look like a girl, not an underfed and really short boy! I'm sure your body is beautiful at its current weight. Don't worry a bit, shore girls are adorable. :)00|00|1


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Edited By: P Millar, J J Lauvergne and C Dolling
Wageningen Academic Publishers
Mendalian Inheritance in Cattle 1999 (MIC 99) is a comprehensive catalogue of those genes in cattle which have identifiable effects on the phenotype. The locus entries are presented in three categories: category 1 embreaces Coat Colour; Category 2 Visible Traits other than Coat Colour and Category 3 loci controlling blood and milk polymorphisms. Publications relating to the alleles at the locus are listed in chronological order for each locus entry, and an assessment was made of the reliability of the evidence presented for each allele. Category 4 relates to mapped loci and other genetic systems in cattle. As the genomic location of a locus is determined, the location is cross-referenced to the appropriate locus entry. As a result MIC 99 forms a link between the gene mapper and the cattle breeder. The breeder can consult MIC 99 to learn what a gene does, and, if its genomic location is known, where to find it. MIC 99 is the third catalogue in the COGNOSAG series, following a catalogue of genes with identifiable effect on the phenotypes of goats (COGNOSAG Workshop 1987) and Mendelian Inheritance in Sheep 1996 (MIS 96). Catalogues covering other domestic species are scheduled for the future.
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In its efforts to ensure that barely an hour of its primetime goes unfilled with scenes of Gordon Ramsay shouting and casting aspersions on what dogs eat for dinner, Fox has crafted a summer TV schedule that will put Masterchef and Hell's Kitchen back to back on both Monday and Tuesday nights, beginning the week of July 18. The rest of the week will then proceed with Wednesday and Thursday episodes of Mary Murphy screeching at people on So You Think You Can Dance, leading to a Saturday night of drunk people yelling at each other on two straight hours of Cops. This will be a very loud summer.
Submit your Newswire tips here.


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Watch way of the wicked 2014 full free movie online. Lawrence Salva's script centers on a detective (Facinelli), on the trail of a murderer, who is led to believe that a local teenager, harboring some sort of strange supernatural power, may be involved. Slater plays the man's disbelieving boss, while Hauer plays a man-of-the-cloth who aids the cop on his mission.
If you're unable to stream the movie, Please refresh the page by pressing F5 button and try to play the movie!
Published on August 8, 2016 by admin


text: Sorting type: Most visited Most visited Alphabetical | Pages in category "Music composed by Etsuko Yoneda" " Etsuko Yodena (米田 悦子, Yoneda Etsuko?) was a composer for the BIOHAZARD OUTBREAK Original... Etsuko Yoneda Freezer Burn Gallery Screen Hell on Earth Split Seconds The Fire Within The Plague Cometh Retrieved from "http://residentevil.wikia.com/wiki/Category:Music_composed_by_Etsuko_Yoneda?oldid=270751" Ad blocker interference detected! Wikia is a free-to-use site that makes money from advertising. We have a modified experience for viewers using ad blockers Wikia is not accessible if you've made further modifications. Remove the custom ad blocker rule(s) and the page will load as expected. Categories: Music by composer


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Ghirardelli Double Chocolate Cookies
READY IN: 27mins
Recipe by podapo
Chocolate Brownie like Heaven!! I substituted Peanut Butter chips for the chocolate chips. From the Ghirardelli Semi-sweet baking bar.
Top Review by OzMan
I am so sorry Po, as I made these quite awhile back and just forgot to review them until I saw the Yummy Photo! :( I loved these CC Cookies, although I did leave out the walnuts, and I used a combination of milk/semi-sweet chips. Outstanding cookie that I will be making again. Thank you so much! :)
See Discussion:1 Review
Ingredients Nutrition
- 8 ounces semi-sweet chocolate baking squares, bars (ghirardelli)
- 3⁄4 cup packed brown sugar
- 1⁄4 cup butter, softened
- 2 eggs
- 1⁄2 teaspoon vanilla extract
- 1⁄2 cup flour
- 1⁄4 teaspoon baking powder
- 1 cup ghirardelli 60% cocoa bittersweet chocolate chips (I again used PB chips)
- 2 cups walnuts (optional)
Directions See How It's Made
- Preheat oven to 350°.
- Break chocolate bar into 1" pieces, Melt semi-sweet chocolate according to melting instructions, (I use a double-boiler on the stovetop).
- Stir in brown sugar, butter, eggs and vanilla.
- In separate bowl, mix flour and baking powder.
- Add flour mixture to the chocolate mixture, mixing well.
- Fold in chocolate chips and nuts.
- Drop by 1/4 cup onto ungreased cookie sheet.
- Bake 12-14 minutes.
- Cool 1 minute on baking sheet, remove to wire cooling racks.


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Over the weekend we experienced an issue with our mail server that was preventing verification emails from being sent. As a result, this caused an additional issue with some email providers blocking our emails. Please take the following steps and then try again:
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We are also seeing instances where our verification emails are arriving later than usual. In these cases it is possible that the verification link in the email message may already be expired if a new email is queued to be sent out. If you received a verification email but the link is not working, please delete the current mail and try logging into the account once more. Wait at least 15 minutes to see if you receive a new verification email, and try using the link in the most recent message.
UPDATE: This issue has been resolved. Customers should be able to receive verification emails again.


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Majestic New York Mets Pink Infant My First T-shirt
You have to start your kids out young if you want to indoctrinate them to love your favorite sports team and what an adorable way to do it with this t shirt. So cute!
Wrap your baby up tight in this bath towel after their first bath and let them know that this family only supports the Mets! Indoctrination needs to start young!Tags: baby, childrens, baseballs, towels, infant, bath towels, mlb, major league baseball, New York MetsAdded 9 Years Ago from Amazon.com
This Mr Potato is adorable and a great gift for your Mets fan kid. I especially love the mouth option that is blowing a bubble of gum. Too cute! Go Mets!Tags: toys, kids, childrens, baseballs, Mr. Potato Head, collectables, mlb, major league baseball, New York MetsAdded 9 Years Ago from Amazon.com
Start your kids out early on their love of the Dodgers with this replica jersey. And start them out with one of the stars of the current Dodger team Russell Martin!Tags: kids, childrens, apparel, jerseys, youth, Dodgers, Los Angeles Dodgers, mlb, replica jerseysAdded 9 Years Ago from Amazon.com
I wish these shoes came in adult sizes! The baseballs on the side light up! How awesome is that! Keep you kids decked out in Dodger gear from head to toe!Added 9 Years Ago from Amazon.com
Your newborn needs to know which team reigns supreme and this onesie is the perfect way to show it. This Dodgers logo onesie will for sure get you and your baby on the jumbotron!Added 9 Years Ago from Amazon.com


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Web Content, Digital Assets, Form Builder, SEO Tools, Decision Support
Multisite Management, Multilingual Support, Site Synchronization, Deployment Options, Security, Scalability
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Integration Platform, Connector for Salesforce, Connector for Microsoft Dynamics CRM, Connector for Marketo, Connector for SharePoint
Product Catalogs, Multiple Storefronts, Targeted Offers, Payment Processing, Order Management
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Behaviour Tracking, Data Integration, 360° Customer Profile
Audience Segmentation, Predictive Analytics, Campaign Recommendations, Campaign Tracking
Marketing Attribution, Conversion Tracking, Persona Profiling, Lead Scoring
Predictive Personalization, Persona-Based Targeting
I am upgrading the site from sitefinity 7.0 to 9.0 and getting below error. We have license for SF 7.0 till next year, do we need to get separate license for newer version
You will activate a license for Sitefinity CMS Professional.
Check the license details
Wrong product version
License details
The following parameters are applied for all domains
Concurrent users:
Published content items:
Published Pages:
Hi Lalit,
Something wrong with references. Try to do this
1) Download Project Manager for version 9.0.6010.0 and go to _EmptyProject\bin folder
2) Compare files from this folder with files in your solution
3) Compare web.configs, maybe you have some old assemblyBindings
Regarding the licence, after an upgrade, you need to download licence for a new version of Sitefinity, the licence file is working only for the specific version.
Make Sitefinity work best for you.
Learn how
Progress, Telerik, Sitefinity and certain product names used herein are trademarks or registered trademarks of Progress Software Corporation and/or one of its subsidiaries or affiliates in the U.S. and/or other countries.


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Thank you to all of our patrons, sponsors, musicians and volunteers who helped make this season a big success.
As we say a fond farewell to Maestro McNeiland we are opening our sights, sounds and ambitions welcoming a new conductor to the St. Augustine Orchestra Maestro Scott Gregg.
So check back towards the end of summer and you will find us here with a new look inspired to bring another season of beautiful orchestral music to St. Augustine!


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Latest News as of: July 11, 2001
July 11, 2001
Just a quick note to let everyone know how the site is shaping up, Traffic-wise. Your Cub Site now sees 1,400 to 1,900+ visitors EACH WEEK! The word is getting out. If you or a friend has a Cub, this is THE place to be seen and more importantly, THE place to tell your story - about your Cub. Needless to say - I'm very pleased with our increased visibility.
May 29, 2001
As many of you already know, the domain address http://cubsite.com is now re-directing users to the Cub Site. I hope this is a temporary system and that I can fund the Cub Site on it's own domain. One way I'm trying to do that is by offering E-Mail addresses on the Cub Site. Your email address could be firstname.lastname@example.com or something like that if you're interested. Go here and read how it works.
March 9, 2001
Big news! I have secured the domain name I have been trying to get for the Cub Site from the beginning. The domain name was reserved and parked by a fan of the Chicago Cubs. It appears that Cub fan has realized exactly what it takes to maintain a web site - especially when the web site is dealing with a commercial enterprise that has not commissioned the Web Site owner to host the site. Consequentially they have allowed the registration to lapse and the domain names that were reserved became available yesterday. I now own - and for the next 10 years will own the domain name cubsite.com. It will take some time and some doing to get everything moved but soon [I'm already working on it] you will find the Triumph Tiger Cub and Terrier Web Site at http://www.cubsite.com. Do not try to use that address yet - it will only take you to the owners registered site [my corporate site front door] and become a dead end.
January 6, 2001
Peter Thiel has obviously been "surfing" around and found a pretty slick site for the Vintage Dirt Track Racers Association and asked them to add a link to us. Poke around some and you'll find a poster from 1961 noting Eddie Cliffords Top Honors for short-tracking his Tiger Cub and at least one poster of Gary Nixon and his Cub. I have VDTRA linked on the Information Page.
December 17, 2000
I have removed the Hits Counter [You are visitor number XXXX] from the front door. The Cub Site has averaged 800 to 850 hits a month on the front door. The "Information Page" [Cool Links] has averaged 1,600 a month with a high of 1,951 hits over the past 30 day period. It appears people are creating links of their own in their Favorites and by-passing the front door, making the counter wrong. It slowed access to the Site some so it's not really missed.
December 9, 2000
Several updates and a new feature. The new feature is the addition of a Forum for the Tiger Cub Site. This Forum will add archive capability to the system. I have also discontinued linking the "Updated" graphic. It simply isn't being used enough to make it worth the time it takes to link. Check out the People page and the Cool Links page for additions.
August 5, 2000
Did you know that if you click on the small "Updated" graphic at the top of the People Page (next to the date of the last update), it will take you to the newest update on that page? Just thought I'd mention it since no one has used it but me.....<G>
June 28, 2000
Correction: Noted as being owned by Dan Andrade, below, The oldest known Restored Terrier in the world is owned by Ray Corlew. I misunderstood Ray's comments to mean he simply did the restoration for Dan. Actually, Dan sold the bike to Ray. Sorry for the confusion.
June 10, 2000
The oldest known Restored Terrier in the world has been added to the Cub Site! Restored by Ray Corlew, owned by Dan Andrade. Check the People Page often. There's more to come. Peter Thiel is sending some Cub Reprints from old British magazines, James Hallett is going to try and find some pictures from a recent Poker Run Bermuda that had 20 or 30 Cubs participate, David Stubbs is sending some photo's of his Cub -- Lots more to come.
June 2, 2000
Whew! Just a quick note to let you know I haven't given up on the site. I've been in and out of town a lot lately and have just gotten bogged down with work. Since that's where the money comes from that make this site available, well - you get the picture. I'm hoping to get Ray Corlew's bikes scanned in and his stories up soon, as well as a link Peter Thiel provided. Please be patient - It'll get done, I just can't commit to when just yet. Ride safe.
May13, 2000
I asked that you tell me what you think. Some did. The result is I have removed the Comet Cursors, I un-wittingly added to some of the pages. Allowing or forcing a script to run from a Web Site can cause a serious problem on the viewers computer. Having warned folks for years about those type pages, I was guilty of it myself. It was pointed out by a friend I have been warning from the start - Something to do with practice what you preach! Thanks Rob.
May12, 2000
I have decided that some changes need to be made in several areas of the Tiger Cub Web Site. Most notably, I'm changing my corporate host to improve performance and reliability. This will have no impact on the web address that you use or how you view the Tiger Cub Web Site, other than less latency in page uploads. Unfortunately, there may be a day or so of outages while I move the site to the new host. I'll try to keep it as brief as possible but please be patient while improvements are being made.
I am also considering changing the software I use to maintain the Cub E-Mail list. If I do change it, you will probably receive an E-Mail message from the list telling you it has changed.
No action is required on your part and all subscribers to the Cub List (firstname.lastname@example.com) will be moved to the new software. Well, it didn't go as planned, sorry. You will have to re-subscribe to the Mailing list. Go here to find out how.
Last but not least - do you think we need a Cub Forum here? I have been considering it but don't care to add it - it's a good deal of work and space to set up - unless it would be worthwhile. Do you think the Cub List handles your needs or do you think a Forum would be useful.
Your input counts. Tell me what you think.


text:
Find a copy in the library
Finding libraries that hold this item...
|Juvenile works
Children's nonfiction
Juvenile literature
|Material Type:
|Juvenile audience
|Document Type:
|All Authors / Contributors:
Don L Wulffson; John R Jones
|0525650709 9780525650706
|OCLC Number:
|128 pages : illustrations ; 24 cm
|Package for Grandma --
Funny thing happened on the way to --
Man in the flying chair --
Buddy-system driving --
He knew there was something he'd forgotten --
No dogs allowed --
Long-lost stranger --
Bad break --
Worst bank robbers --
Grand theft --
In the pen --
Icy standoff --
Cop who became his own prisoner --
Lesson in geography --
Killer sues prison --
Frozen alive --
Fall out, fall in --
Favor returned --
Tidal wave! --
Miracle --
Baseball wasn't his thing --
E-less novel --
Longest Painting --
Portrait of death --
$5,216 fine for an overdue book --
Book that foretold the future --
How many hours in a day? --
Frog in a rock --
Human radio --
Comical idea --
Woman who couldn't sleep --
Foot powder mayor --
Law going nowhere --
Do-nothing congressman --
Senor Banana --
King Henry I of America --
Into thin air --
Water from nowhere --
Message from the grave? --
Electric lady --
Floating man --
Dream come true --
Coming home --
Football game won by unconscious player --
Fair trade --
Five on one --
Best catch ever --
Karate team knocks house down --
His own worst enemy --
Skier in hot water --
Have you ever seen a frozen breath? --
Human hailstones --
Little heat wave! --
Rain out of a clear blue sky.
|Don L. Wulffson ; illustrated by John R. Jones.
A collection of unusual stories that are hard to believe but true, in such categories as "Travel and Transportation," "Crime and Punishment," and "Accidents and Disasters."
User-contributed reviews


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Johnston Press editor Nick Proctor has left his position after 20 years.
The weekly editor of the Bridlington Free Press, Driffield Times & Post, Pocklington Post and Beverley Guardian leaves to begin his role as communications manager at East Riding of Yorkshire Council.
Starting as a trainee reporter with the Scarborough Evening News, Proctor worked his way to editor of the Bridlington Free Press nine years ago.
It is yet to be confirmed whether Proctor will be replaced as editor of these titles.


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What is JotForm?
JotForm is a free online form builder which helps you create online forms without writing a single line of code. No sign-up required.
At JotForm, we want to make sure that you're getting the online form builder help that you need. Our friendly customer support team is available 24/7.
We believe that if one user has a question, there could be more users who may have the same question. This is why many of our support forum threads are public and available to be searched and viewed. If you'd like help immediately, feel free to search for a similar question, or submit your question or concern.
[Using Custom CSS] Edge of form cut offAsked by Jessrk on January 07, 2014 at 12:25 PM
Hi there.
As you can see, the edge of my "message" box is missing.
I have tried everything... (embedding in dreamweaver, imbedding with iframe and the normal embed... the imbedding only messes up my scripts on the page so this is with the iframe).
I can't see which width should change (I have it at 700 in jotform)
In order to fixed the issue, you need to use and inject some custom css into your form.
Here's the code you need:
textarea#input_8.form-textarea {
width: 280px !important;
Anyways, I've injected it already in your form. You might like to take a look at your website now: http://www.jessrk.com/contact/contact-en.html
If you need further assistance, please feel free to contact us at anytime.
Thank you oh so very much :)
It's my pleasure! If you need our assistance again, please feel free to contact us at anytime.
Have a nice day!


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MUSKOGEE, Okla. — When BASS announced that the AutoZone Sooner Run would be held in Muskogee, Tommy Biffle, who lives just a long pitch away from the Arkansas River, no doubt smiled. On a scale of one to 10, his grin might've registered a 7.
When the tournament was moved to Fort Gibson Lake, his home body of water, with only a day of practice for everyone, it might've jumped up to an 8.
Now that he's finished the first day of the tournament in first place, and garnered the bonus points that come with that, the relatively non-emotional Oklahoman is likely pushing a 9.
If he's in the same position when the scales close on Sunday, he may hit a perfect 10 ... or even an 11. He's known for late-season charges, but this one couldn't have set up any better if he'd drafted the plot lines himself.
Biffle's tournament leading 19-pound, 11-ounce limit of Fort Gibson bass vaulted him from a four-way tie for 17th in the Toyota Tundra Angler of the Year (TTBAOY) standings all the way up to eighth place. If the regular season ended today, he'd be in the two-event postseason.
The other two 19-pound plus sacks also came from anglers who were outside of the top 12 coming into Thursday. Russ Lane, second after Day One with 19-10, moved from 15th in the TTBAOY up to seventh.
While a spot in the postseason would be meaningful for any Elite Series angler, Lane, who calls Prattville, Ala., home, might be a prohibitive favorite to win either or both July events. Mike McClelland caught 19-08 and moved up from 23rd to 12th.
For every angler who moves into the post-season cut, another has to fall out, and while 10 of the top 12 heading into Day One weighed 12-13 or more, two produced comparatively paltry single-digit weights which made it possible for Biffle, Lane and McClelland to capitalize.
Brian Snowden, previously in fourth, weighed in 7-2 and dropped to 15th. John Crews, previously in fifth, finds himself in 88th place in the tournament and dropped to 16th in the TTBAOY list. Bill Lowen was the third angler to fall out of the top 12. Even though he weighed in a strong 14-4, good weights in front of him and behind him forced him down three places to 14th.
Of course all of these standings are temporary. While Biffle's bonus points for leading Day One cannot be taken away, everything else is dynamic. An angler who caught 19 pounds might blank Friday.
An angler with a single-digit catch could bust a 25-pound sack and come back from the dead. This is further complicated by the bell-curve nature of the scoresheet. Seventeen anglers had 16 pounds or more and 19 had less than 10 pounds.
The other 58 are within one good bite of one another. To illustrate how closely they're bunched, Gary Klein, the last man inside the current top 12, weighed 16 pounds even. Wade Grooms and Bradley Roy, tied for 47th, are just over 3 pounds behind at 12-12 apiece. Another 2-11 separates those two from Guy Eaker in 73rd.
At the very top of the list, Nos. 1-3 remained constant, and in the same order — Skeet Reese, Edwin Evers and Derek Remitz. Reese, who's suffered a mini-swoon over the past two tournaments, is in 19th overall while the other two are in 43rd and 44th, respectively. If the tournament ended today, Reese would have extended his pre-tournament lead over Evers from 62 points to 110 points and his lead over Remitz from 148 to an even 200 points.
Combined with the bonus points from his two wins, that should make Reese feel pretty good, even though the differences will be reduced by the postseason points adjustment.
One thing that should have all three feeling less than chipper is the angler who has moved into fourth place, only 41 points behind Remitz. Apparently the rumors of Kevin VanDam's demise were greatly exaggerated. With a win at Kentucky Lake last week and a 17-10 bag Thursday, he seems to be peaking at the right time. Reese led the TTBAOY standings at the end of the 2009 season only to see VanDam wrest the title from him in Alabama. It can't be comforting to know that KVD and his magic cookies may get to take their mojo on the road for two extra small field events.
Terry Butcher, Cliff Pace, Aaron Martens, Greg Hackney and Gary Klein all held onto spots in the top 12 for another day. For Pace and Klein, this would represent repeat appearances in the postseason. Martens, on the other hand, would like to avoid the late-season collapse that prevented him from fishing the Alabama River and Lake Jordan last summer.
One other angler who improved his lot with respect to the post-season today was Mark Davis, who was stuck in the four-way tie for 17th with Biffle and two others but weighed 16-1 to move into 13th. On the other hand, Dave Wolak, previously the first man out, weighed a pedestrian 11-0 and dropped to 22nd. He's not out of the hunt by any means, but he'll have to have a better day if he's going to hit the 26 pounds or so it'll likely be necessary to have to fish on to Saturday.
With Kevin VanDam's spot in the top 36 in the TTBAOY all but assured, the Elite Series Classic qualifiers will go at least 37 deep, more if there are double-qualifiers. Kelly Jordon, sitting on the bubble in 37th, held onto that position with an unremarkable 11-4 limit. While there was movement all around him, most of it was not consequential, at least for the time being.
Clark Reehm, aiming for his second Classic berth, weighed in 4-3 and dropped from 35th to 43rd in the TTBAOY standings. Balancing him out was Jared Lintner, whose 18-5 moved him up from 39th to 30th and therefore from the outside to the inside of the Classic cutoff.
Another drop of note was Denny Brauer, looking to qualify for consecutive Classics for the first time in over a decade. He sat just outside the cut heading in, in 40th, 48 points behind Jordon, but his 8-5 limit knocked him back 14 places, to the bottom half of the standings sheet.
Around the Classic cut line, several anglers faltered but did not fall out: Shaw Grigsby fell from 25th to 31st; Jason Williamson, who has finished in the 40s in the TTBAOY all three years he's fished the elites, fell 11 places from 21st to 32nd; Terry Scroggins fell from 30th to 34th; Bobby Lane dropped from 26th to 35th; and Greg Vinson, another Alabamian who'd love to fish the postseason, also moved in the wrong direction, plunging from 28th to 36th.
On the flip side, the four anglers who are now just behind Jordon all moved up in the standings to get there: Former Classic winner Paul Elias, who hasn't fished a Classic since 2004, moved up from 44th to 38th; Mark Tucker, who was the final angler to make the Classic through the Elite Series last year, qualifying only when James Niggemeyer double-qualified, moved up two spots to 39th; Niggemeyer also moved up, from 47th to 40th; and Davy Hite, currently in 13th place in the tournament, jumped a remarkable 14 places, from the bottom half of the TTBAOY list into 41st.
Absent a miraculous comeback tomorrow, fan favorite Guy Eaker, who announced before the 2010 season that this would be his last on tour then started the year with a bang over the first several events, will not qualify for his first Classic since 1992. While his 10-1 catch doesn't definitively preclude him from making a comeback, it dropped him 15 places overall today, from 58th to 73rd. The chances that he'll overcome that deficit seem slim.


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Each month, Rated People connects over 50,000 homeowners with quality tradesmen - simply enter your job details in the form above to get started.
We'll match your job to the relevant tradesmen in your area - those interested will pay to see your contact details and call you to quote.
As each tradesman expresses interest in quoting on your job, we'll send you their profile and ratings to help you choose the right one for you.
After the work is complete, return to the site and rate your tradesman based on their quality of work, reliability and value for money.
Swimming Pool Specialist
Added 07/01/2010
The house we are likely to buy has a disused pool. It is about 5m x 3m, in-ground and concrete...
Searching for tradespeople
Managing your job is easier with the Rated People Homes App, download it today.


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Editors' pick: Originally published Nov. 17.
The big question these days is, should we even call it retirement any more?
According to a survey by the Transamerica Center for Retirement Studies: "Sixty-somethings and older workers are casting aside long-held societal notions about fully retiring at age 65."
The report, Retirement Throughout the Ages: Expectations and Preparations of American Workers, says 82% of Americans surveyed plan to or are already working past age 65, or, they have no plans to retire.
Justin Halverson, of Great Waters Financial in Minneapolis, says he has seen the trend among his clients. "They either want to do it for the money or they just want to stay active, stay engaged and look for social interaction and social purpose."
Which brings us to the question. Why are some people successful in those post retirement jobs or careers while others are unsuccessful.
According to financial planners and jobs experts, the keys to having that successful encore career are purpose, passion and planning.
Author and career expert Kerry Hannon says the people who are the most successful are those who have taken the time to plan the move, and have not made rash decisions.
"I takes three to five years to set yourself set up in an encore career," she says. "You need to add skills you might need, network and find out what the job is about. Also, get financially fit and pay down debt so you're not dependent on making a lot of money.
"The successful ones take their time, moonlight and do the job first to lay the groundwork," she says. "They start in baby steps before they leave their careers."


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Welcome to Taryns Tiny Tots Playschool. Located in beautiful Emmett ID, close to the High School and in a central location right on one of the schools bus routes. I have limited spots available and rates comparable to ICCP. I are not ICCP certified, but I am CPR and First Aid certified. I can provide full time, part time, before and after school care. I am in the Shadow Butte school district and the bus stops right in front of my house.
Contact me today!
Thank you so much!
Taryn Davis


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Loads Available
This page lists what truckloads we have available.
Make sure you bookmark this page and reload it (refresh) often as merchandise changes constantly and quickly or
go to the bottom and enter your e-mail to join up for our latest Hot Sheets and News.
As always - please remember to read our F.A.Q. before purchasing any items.
This page was last updated - 08/25/16 05:52 PM -0400
Salvage Grocery Truckload!
53' Truckload - 1,248 boxes (26 pallets @ 48 boxes each)
The load consists of:
Cleaning Products
Paper Items
Pet Food
1 load available per week
Truckloads only
FOB Northeast
Loads with water only $12.25 a box!
(1,248 boxes = $15,288 a load)
Loads without water only $13.25 a box!
(1,248 boxes = $16,536 a load)
Other pallets of items are available to substitute for the Food Pallets in your the grocery truckload mix...
(generally there are only 1-2 pallets of each of these available per grocery load-
these are only available when ordering a regular grocery load and are more expensive per box)
If you are looking for a great mix call us today!
Candy - $960 ($20 a box)
HBA - $2016 ($42 a box)
Loads are pre-sold and are currently 3 weeks in advance.
Finally- when buying groceries- you'll need to fax us (803-643-0801) a copy of your
state, local or county salvage license- this can usually be obtained through your State's Agricultural Department
and a copy of your state sales tax license or 501C3.
If you are looking to buy by the truckload, call Rob @ 803-215-8823.
Salvage Truckloads of
Seasonal Merchandise Available
48' Truckload - 24 pallets
The load consists of:
Christmas Trees
Wrapping Paper
Lawn Ornaments
Outdoor Decorations
and more!!!
Truckloads or Pallets Available while quantities last
FOB Aiken, SC
Only $149 a pallet!
For other truckloads - Call 803-643-0606
or e-mail firstname.lastname@example.com
If you have any questions, feel free to call 1-803-643-0606 or email email@example.com.
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