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I met this guy on an online dating site and I'm really starting to like him. I have never online dated before and since I haven't met him in person yet; it is hard to know if he feels the same. Are there any signs that would help me determine whether he is interested or not?
How to tell if a guy likes you through online dating?
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What Guys Said 2
No, sorry - you are the fish looking at bait with hooks in them passing by On Line
Some are more tempting than others
but only dating will give such a view on the future, which is still a pretty poor vision as many found out the hard way.00|00|0
If he constantly talk to u, and flirts with u (like calling u babe or sweetheart)... he is interested in u.
He may not be ready to meet yet, so be patient. :)00|00|0
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Anyone Used The Cricut To Make A Stencil?
Decorating By LindseyLoocy Updated 8 Jan 2010 , 12:35am by tigerhawk83
Hi all! I got a cricut for Christmas, but haven't been able to experiment with it yet. But now I am need of a Valentine's Day stencil for work and I was wondering if anyone has used the cricut for that purpose, and if so, what material did you use? I need a material that's thick enough for use on a silpat with decorator's paste.
If anyone has any suggestions I will be most grateful! Thanks for looking
yes I have - you can buy blank stencil sheets at Hobby Lobby or Michaels or even Home Depot or Lowes. I set my machine at pressure 6, speed 3, blade setting 5, and multicut 2 (I have an Expression). Worked fine.
I would suggest cutting it first on paper to work out the bugs in your design before going to the stencils. Old calendars are great for this - the paper is stiff (not floppy like construction paper or printer paper) and the price is right because it's FREE.

subset: commoncrawl


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Ado-Trastuzumab Emtansine
(a do tras TU zoo mab em TAN seen)
Index Terms
- Ado Trastuzumab
- Adotrastuzumab
- Trastuzumab Emtansine
- Trastuzumab-DM1
- Trastuzumab-MCC-DM1
Dosage Forms
Excipient information presented when available (limited, particularly for generics); consult specific product labeling.
Solution Reconstituted, Intravenous [preservative free]:
Kadcyla: 100 mg (1 ea); 160 mg (1 ea) [contains mouse (murine) and/or hamster protein]
Brand Names: U.S.
- Kadcyla
Pharmacologic Category
- Antineoplastic Agent, Anti-HER2
- Antineoplastic Agent, Antibody Drug Conjugate
- Antineoplastic Agent, Antimicrotubular
- Antineoplastic Agent, Monoclonal Antibody
Ado-trastuzumab emtansine is a HER2-antibody drug conjugate which incorporates the HER2 targeted actions of trastuzumab with the microtubule inhibitor DM1 (a maytansine derivative). The conjugate, which is linked via a stable thioether linker, allows for selective delivery into HER2 overexpressing cells, resulting in cell cycle arrest and apoptosis.
Vd: 3.13 L
DM1 undergoes hepatic metabolism via CYP3A4/5
Time to Peak
Near the end of the infusion
Half-Life Elimination
~4 days
Protein Binding
Special Populations: Hepatic Function Impairment
Systemic exposure (AUC) was ~38% and ~67% lower in patients with mild (Child-Pugh class A) and moderate (Child-Pugh class B) impairment, respectively, compared to patients with normal hepatic function during cycles 1 and 2 of a 3.6 mg/kg ado-trastuzumab dose.
Use: Labeled Indications
Breast cancer, metastatic: Treatment (single-agent) of HER2-positive, metastatic breast cancer in patients who previously received trastuzumab and a taxane, separately or in combination, and have either received prior therapy for metastatic disease or developed disease recurrence during or within 6 months of completing adjuvant therapy.
US labeling: There are no contraindications in the manufacturer's labeling.
Canadian labeling: Hypersensitivity to trastuzumab emtansine or any component of the formulation.
Dosing: Adult
Note: Do not substitute ado-trastuzumab emtansine (US) or trastuzumab emtansine (Canada) for or with conventional trastuzumab; products are different and are NOT interchangeable.
Breast cancer, metastatic, HER2+: IV: 3.6 mg/kg every 3 weeks until disease progression or unacceptable toxicity; Maximum dose: 3.6 mg/kg
Missed or delayed doses: If a planned dose is missed or delayed, administer as soon as possible (at the dose and rate most recently tolerated), do not wait until the next planned cycle. Then adjust schedule to maintain a 3-week interval between doses.
Dosing: Geriatric
Refer to adult dosing.
Dosing: Renal Impairment
CrCl ≥30 mL/minute: No dosage adjustment necessary.
CrCl <30 mL/minute: There are no dosage adjustments provided in the manufacturer's labeling (has not been studied).
Dosing: Hepatic Impairment
Hepatic impairment prior to treatment initiation:
Mild to moderate impairment (Child-Pugh class A or B): No dosage adjustment necessary; use with caution.
Severe impairment (Child-Pugh class C): There are no dosage adjustments provided in the manufacturer's labeling (has not been studied).
Hepatotoxicity during treatment: Refer to dosage adjustment for toxicity for dose level reductions:
Grade 2 ALT, AST elevations (>2.5 to ≤5 times ULN): Continue at same dose level.
Grade 3 ALT, AST elevations (>5 to ≤20 times ULN): Withhold until ALT, AST recover to ≤grade 2, then resume with one dose level reduction.
Grade 4 ALT, AST elevations (>20 times ULN): Permanently discontinue treatment.
Grade 2 hyperbilirubinemia (>1.5 to ≤3 times ULN): Withhold until bilirubin recovers to ≤grade 1 (≤1.5 times ULN), then resume at the same dose level.
Grade 3 hyperbilirubinemia (>3 to ≤10 times ULN): Withhold until bilirubin recovers to ≤grade 1, then resume with one dose level reduction.
Grade 4 hyperbilirubinemia (>10 times ULN): Permanently discontinue treatment.
Concomitant ALT, AST >3 times ULN and total bilirubin >2 times ULN: Permanently discontinue treatment.
Nodular regenerative hyperplasia: Permanently discontinue treatment.
Dosing: Adjustment for Toxicity
Note: After a dose reduction is implemented, do not re-escalate dose.
Infusion-related reaction: Slow infusion rate or interrupt infusion. Permanently discontinue if life-threatening infusion reactions occur.
Dose levels for dosage reductions and/or discontinuation:
Starting dose: 3.6 mg/kg
First dose reduction: Reduce dose to 3 mg/kg
Second dose reduction: Reduce dose to 2.4 mg/kg
Further reductions necessary: Discontinue treatment.
Hematologic toxicity:
Grade 3 thrombocytopenia (platelets 25,000/mm3 to <50,000/mm3): Withhold treatment until platelet count recovers to ≤ grade 1 (platelets ≥75,000/mm3), then resume treatment at the same dose level.
Grade 4 thrombocytopenia (platelets <25,000/mm3): Withhold treatment until platelet count recovers to ≤ grade 1 (platelets ≥75,000/mm3), then resume treatment with one dose level reduction.
LVEF >45%: Continue treatment.
LVEF 40% to ≤45% and decrease is <10% points from baseline: Continue treatment and repeat LVEF assessment within 3 weeks.
LVEF 40% to ≤45% and decrease is ≥10% points from baseline: Withhold treatment and repeat LVEF assessment within 3 weeks; if repeat LVEF has not recovered to within 10% points from baseline, discontinue treatment.
LVEF <40%: Withhold treatment and repeat LVEF assessment within 3 weeks; if repeat LVEF is confirmed <40%, discontinue treatment.
HF (symptomatic): Discontinue treatment.
Peripheral neuropathy, grade 3 or 4: Temporarily discontinue until resolves to ≤ grade 2.
Pulmonary toxicity: Interstitial lung disease or pneumonitis: Permanently discontinue.
Check vial labels to assure appropriate product is being reconstituted (ado-trastuzumab emtansine and conventional trastuzumab are different products and are NOT interchangeable).
Slowly inject sterile water for injection into the vial (5 mL for 100 mg vial or 8 mL for 160 mg vial) to a reconstituted concentration of 20 mg/mL. Gently swirl vial until completely dissolved. Reconstituted solution will be clear or slightly opalescent (there should be no visible particles) and colorless to pale brown. Dilute for infusion by adding to 250 mL sodium chloride 0.9%; gently invert bag to mix (do not shake).
Check label to ensure appropriate product is being administered (ado-trastuzumab emtansine [US] or trastuzumab emtansine [Canada] and conventional trastuzumab are different products and are NOT interchangeable).
Infuse over 90 minutes (first infusion) or over 30 minutes (subsequent infusions if prior infusions were well tolerated) through a 0.2 or 0.22 micron inline nonprotein adsorptive polyethersulfone filter. Do not administer IV push or bolus. Do not administer with other medications.
Monitor patient during infusion for signs of infusion-related reactions (eg, fever, chills); monitor for at least 90 minutes following initial infusion and (if tolerated) for at least 30 minutes following subsequent infusions.
May be a vesicant; avoid extravasation. Ensure proper needle or catheter position prior to administration. Closely monitor infusion site during administration.
Extravasation management: If extravasation occurs, stop infusion immediately and disconnect (leave cannula/needle in place); gently aspirate extravasated solution (do NOT flush the line); remove needle/cannula; elevate extremity.
See Trissel's IV Compatibility Database
Store intact vials at 2°C to 8°C (36°F to 46°F). Do not freeze or shake intact vials, reconstituted solution, or solutions diluted for infusion. Reconstituted vials do not contain preservative and should be used immediately, although may be stored for up to 24 hours at 2°C to 8°C (36°F to 46°F). Solutions diluted for infusion in NS should be used immediately, although may be stored at 2°C to 8°C (36°F to 46°F) for up to 24 hours prior to use. This storage time is additional to the time allowed for the reconstituted vials.
Drug Interactions
Antineoplastic Agents (Anthracycline, Systemic): Ado-Trastuzumab Emtansine may enhance the cardiotoxic effect of Antineoplastic Agents (Anthracycline, Systemic). Management: When possible, patients treated with ado-trastuzumab emtansine should avoid anthracycline-based therapy for up to 7 months after stopping ado-trastuzumab emtansine. Monitor closely for cardiac dysfunction in patients receiving this combination. Consider therapy modification
Aprepitant: May increase the serum concentration of CYP3A4 Substrates. Monitor therapy
BCG (Intravesical): Immunosuppressants may diminish the therapeutic effect of BCG (Intravesical). Avoid combination
BCG (Intravesical): Myelosuppressive Agents may diminish the therapeutic effect of BCG (Intravesical). Avoid combination
Belimumab: Monoclonal Antibodies may enhance the adverse/toxic effect of Belimumab. Avoid combination
CloZAPine: Myelosuppressive Agents may enhance the adverse/toxic effect of CloZAPine. Specifically, the risk for neutropenia may be increased. Monitor therapy
Coccidioides immitis Skin Test: Immunosuppressants may diminish the diagnostic effect of Coccidioides immitis Skin Test. Monitor therapy
Conivaptan: May increase the serum concentration of CYP3A4 Substrates. Avoid combination
CYP3A4 Inhibitors (Moderate): May decrease the metabolism of CYP3A4 Substrates. Monitor therapy
CYP3A4 Inhibitors (Strong): May increase serum concentrations of the active metabolite(s) of Ado-Trastuzumab Emtansine. Specifically, strong CYP3A4 inhibitors may increase concentrations of the cytotoxic DM1 component. Avoid combination
Dasatinib: May increase the serum concentration of CYP3A4 Substrates. Monitor therapy
Deferiprone: Myelosuppressive Agents may enhance the neutropenic effect of Deferiprone. Avoid combination
Denosumab: May enhance the adverse/toxic effect of Immunosuppressants. Specifically, the risk for serious infections may be increased. Monitor therapy
Dipyrone: May enhance the adverse/toxic effect of Myelosuppressive Agents. Specifically, the risk for agranulocytosis and pancytopenia may be increased Avoid combination
Echinacea: May diminish the therapeutic effect of Immunosuppressants. Consider therapy modification
Fingolimod: Immunosuppressants may enhance the immunosuppressive effect of Fingolimod. Management: Avoid the concomitant use of fingolimod and other immunosuppressants when possible. If combined, monitor patients closely for additive immunosuppressant effects (eg, infections). Consider therapy modification
Fosaprepitant: May increase the serum concentration of CYP3A4 Substrates. Monitor therapy
Fusidic Acid (Systemic): May increase the serum concentration of CYP3A4 Substrates. Avoid combination
Idelalisib: May increase the serum concentration of CYP3A4 Substrates. Avoid combination
Leflunomide: Immunosuppressants may enhance the adverse/toxic effect of Leflunomide. Specifically, the risk for hematologic toxicity such as pancytopenia, agranulocytosis, and/or thrombocytopenia may be increased. Management: Consider not using a leflunomide loading dose in patients receiving other immunosuppressants. Patients receiving both leflunomide and another immunosuppressant should be monitored for bone marrow suppression at least monthly. Consider therapy modification
Natalizumab: Immunosuppressants may enhance the adverse/toxic effect of Natalizumab. Specifically, the risk of concurrent infection may be increased. Avoid combination
Netupitant: May increase the serum concentration of CYP3A4 Substrates. Monitor therapy
Nivolumab: Immunosuppressants may diminish the therapeutic effect of Nivolumab. Consider therapy modification
Ocrelizumab: May enhance the immunosuppressive effect of Immunosuppressants. Monitor therapy
Palbociclib: May increase the serum concentration of CYP3A4 Substrates. Monitor therapy
Pimecrolimus: May enhance the adverse/toxic effect of Immunosuppressants. Avoid combination
Promazine: May enhance the myelosuppressive effect of Myelosuppressive Agents. Monitor therapy
Roflumilast: May enhance the immunosuppressive effect of Immunosuppressants. Consider therapy modification
Simeprevir: May increase the serum concentration of CYP3A4 Substrates. Monitor therapy
Sipuleucel-T: Immunosuppressants may diminish the therapeutic effect of Sipuleucel-T. Monitor therapy
Stiripentol: May increase the serum concentration of CYP3A4 Substrates. Management: Use of stiripentol with CYP3A4 substrates that are considered to have a narrow therapeutic index should be avoided due to the increased risk for adverse effects and toxicity. Any CYP3A4 substrate used with stiripentol requires closer monitoring. Consider therapy modification
Tacrolimus (Topical): May enhance the adverse/toxic effect of Immunosuppressants. Avoid combination
Tertomotide: Immunosuppressants may diminish the therapeutic effect of Tertomotide. Monitor therapy
Tofacitinib: Immunosuppressants may enhance the immunosuppressive effect of Tofacitinib. Management: Concurrent use with antirheumatic doses of methotrexate or nonbiologic disease modifying antirheumatic drugs (DMARDs) is permitted, and this warning seems particularly focused on more potent immunosuppressants. Consider therapy modification
Trastuzumab: May enhance the neutropenic effect of Immunosuppressants. Monitor therapy
Vaccines (Inactivated): Immunosuppressants may diminish the therapeutic effect of Vaccines (Inactivated). Management: Vaccine efficacy may be reduced. Complete all age-appropriate vaccinations at least 2 weeks prior to starting an immunosuppressant. If vaccinated during immunosuppressant therapy, revaccinate at least 3 months after immunosuppressant discontinuation. Consider therapy modification
Vaccines (Live): Immunosuppressants may enhance the adverse/toxic effect of Vaccines (Live). Immunosuppressants may diminish the therapeutic effect of Vaccines (Live). Management: Avoid use of live organism vaccines with immunosuppressants; live-attenuated vaccines should not be given for at least 3 months after immunosuppressants. Avoid combination
Adverse Reactions
Central nervous system: Fatigue (36%), headache (28%), peripheral neuropathy (21%; grades 3/4: 2%), insomnia (12%)
Dermatologic: Skin rash (12%)
Endocrine & metabolic: Decreased serum potassium (33%; grade 3: 3%)
Gastrointestinal: Nausea (40%), constipation (27%), diarrhea (24%), abdominal pain (19%), vomiting (19%), xerostomia (17%), stomatitis (14%)
Hematologic & oncologic: Decreased platelet count (83% [nadir by day 8]; grade 3: 14%; grade 4: 3%), decreased hemoglobin (60%; grade 3: 4%; grade 4: 1%), decreased neutrophils (39%; grade 3: 3%; grade 4: <1%), hemorrhage (32%; grades 3/4: 2%), thrombocytopenia (31%; grades 3/4: 15%; Asians grades 3/4: 45%), anemia (14%; grades 3/4: 4%)
Hepatic: Increased serum AST (98%; grades 3/4: <8%), increased serum ALT (82%; grades 3/4: <6%), increased serum transaminases (29%), increased serum bilirubin (17%)
Neuromuscular & skeletal: Musculoskeletal pain (36%), arthralgia (19%), weakness (18%), myalgia (14%)
Respiratory: Epistaxis (23%), cough (18%), dyspnea (12%)
Miscellaneous: Fever (19%)
1% to 10%:
Cardiovascular: Peripheral edema (7%), hypertension (5%; grades 3/4: 1%), left ventricular dysfunction (2%; grades 3/4: <1%)
Central nervous system: Dizziness (10%), chills (8%)
Dermatologic: Pruritus (6%)
Endocrine & metabolic: Hypokalemia (10%; grades 3/4: 3%)
Gastrointestinal: Dyspepsia (9%), dysgeusia (8%)
Genitourinary: Urinary tract infection (9%)
Hematologic & oncologic: Neutropenia (7%; grades 3/4: 2%)
Hepatic: Increased serum alkaline phosphatase (5%)
Hypersensitivity: Hypersensitivity (2%)
Immunologic: Antibody development (5%)
Ophthalmic: Blurred vision (5%), conjunctivitis (4%), dry eye syndrome (4%), increased lacrimation (3%)
Respiratory: Pneumonitis (≤1%)
Miscellaneous: Infusion related reaction (1%)
<1% (Limited to important or life-threatening): Anaphylactoid reaction, hepatic encephalopathy, hepatotoxicity, nodular regenerative hyperplasia, portal hypertension
ALERT: U.S. Boxed WarningDo not interchange:
Do not substitute ado-trastuzumab emtansine (Kadcyla) for or with trastuzumab (Herceptin).Hepatotoxicity:
Serious hepatotoxicity has been reported, including liver failure and death. Monitor serum transaminases and bilirubin prior to initiation of treatment and prior to each dose. Reduce the dose or discontinue ado-trastuzumab emtansine as appropriate in cases of increased serum transaminases or total bilirubin.Cardiotoxicity:
Ado-trastuzumab emtansine administration may lead to reductions in left ventricular ejection fraction (LVEF). Evaluate left ventricular function in all patients prior to and during treatment. Withhold treatment for a clinically significant decrease in left ventricular function.Pregnancy:
Exposure to ado-trastuzumab emtansine during pregnancy can result in embryo-fetal harm. Advise patients of these risks and the need for effective contraception.
Concerns related to adverse effects:
• Bone marrow suppression: Thrombocytopenia may occur (nadir achieved by day 8; generally resolves to ≤ grade 1 by the next scheduled dose). The incidence of thrombocytopenia may be higher in patients of Asian ancestry. Monitor platelet count at baseline and prior to each dose. May require treatment interruption or dose reduction. Monitor closely if at bleeding risk due to thrombocytopenia and/or concomitant anticoagulant use. Has not been studied in patients with platelets <100,000/mm3 at treatment initiation. Neutropenia and anemia have also occurred.
• Cardiotoxicity: [US Boxed Warning]: May result in left ventricular ejection fraction (LVEF) reductions. Evaluate left ventricular function (in all patients) prior to and at least every 3 months during treatment; withhold for clinically significant left ventricular function decreases. Treatment interruption or dosage reductions are required inpatients who develop decreased LVEF. Use has not been studied in patients with LVEF <50% at baseline, with a history of symptomatic CHF, serious arrhythmia, or recent history (within 6 months) of MI, or unstable angina.
• Extravasation reactions: May be a vesicant; avoid extravasation. Local reactions (erythema, irritation, pain, swelling, or tenderness) secondary to extravasation have been noted. These were generally mild and typically occurred within 24 hours of infusion. There is a case report of skin necrosis (delayed) following extravasation (Shafaee 2017). Monitor infusion site during infusion for possible infiltration.
• Hemorrhage: Hemorrhagic events, including central nervous system, respiratory, and gastrointestinal hemorrhage, have been observed; some hemorrhages were fatal. Some events occurred in patients who were receiving anticoagulation or antiplatelet therapy, or in patients with thrombocytopenia, although bleeding also occurred in patients without additional risk factors. Use caution when administering with antiplatelet agents or anticoagulants; consider additional monitoring when indicated.
• Hepatotoxicity: [US Boxed Warning]: Serious hepatotoxicity, including liver failure and death, has been reported. Monitor transaminases and bilirubin at baseline and prior to each dose. Increases (transaminases or total bilirubin) may require dose reductions or discontinuation. Hepatotoxicity is typically manifested by asymptomatic and transient increases in transaminases, although fatal cases of drug induced liver injury and hepatic encephalopathy have occurred; may be confounded by comorbidities or concomitant hepatotoxic medications. Use with caution in patients with hepatic impairment (has not been studied in patients with baseline serum transaminases >2.5 times ULN or bilirubin >1.5 times ULN, or in patients with active hepatitis B or C virus). Cases of nodular regenerative hyperplasia (NRH), a rare liver disorder characterized by widespread benign transformation of hepatic parenchyma into small regenerative nodules, have been observed (by biopsy). NRH may develop into noncirrhotic portal hypertension. Consider NRH in patients with clinical symptoms of portal hypertension and/or cirrhosis-like pattern seen on liver CT scan, although without associated transaminase elevations or other manifestations of cirrhosis. Diagnosis of NRH is confirmed by histopathology; permanently discontinue if histopathology confirms NRH.
• Hypersensitivity/infusion-related reactions: Infusion reactions (flushing, chills, fever, bronchospasm, dyspnea, wheezing, hypotension, and/or tachycardia) have been reported. After termination of infusion, these reactions generally resolved within several hours to a day. Medications for the treatment of reactions should be available for immediate use. Monitor closely for infusion reactions, especially during initial infusion. If reaction occurs, decrease infusion rate; for severe infusion reactions, interrupt infusion; permanently discontinue for life-threatening reactions. Serious allergic/anaphylactic reaction was observed (rare). Use is not recommended in patients who had trastuzumab permanently discontinued due to infusion reaction or hypersensitivity (has not been evaluated).
• Peripheral neuropathy: Sensory peripheral neuropathy has been reported, usually grade 1, although grade 3 peripheral neuropathy was also described. Monitor for signs and symptoms of neuropathy. May require treatment interruption and/or dose reduction.
• Pulmonary toxicity: Interstitial lung disease (ILD), including pneumonitis has been reported; some cases resulted in acute respiratory distress syndrome and/or fatalities. Permanently discontinue with diagnosis of ILD or pneumonitis. Signs and symptoms of pneumonitis include dyspnea, cough, fatigue, and pulmonary infiltrates; may or may not occur in correlation with infusion reaction. Patients with dyspnea at rest (due to advance malignancy complications or comorbidity) may be at increased risk for pulmonary toxicity.
Concurrent drug therapy issues:
• Drug-drug/drug-food interactions: Potentially significant interactions may exist, requiring dose or frequency adjustment, additional monitoring, and/or selection of alternative therapy. Consult drug interactions database for more detailed information.
Special populations:
• Asian ancestry: The incidence of thrombocytopenia may be higher in patients of Asian ancestry.
• Pregnancy: [US Boxed Warning]: Exposure to ado-trastuzumab emtansine during pregnancy may cause embryo-fetal harm. Effective contraception must be used in women of reproductive potential. Pregnancy status should be verified prior to therapy. Effective contraception is recommended during therapy and for 7 months after the last dose for women of childbearing potential and for 4 months after the last dose in males with female partners of reproductive potential.
Dosage form specific issues:
• Do not interchange: [US Boxed Warning]: Ado-trastuzumab emtansine and conventional trastuzumab are NOT interchangeable. Do not substitute. In Canada, the generic name for Kadcyla is trastuzumab emtansine (ie, lacks Ado- prefix) and may be confused with conventional trastuzumab. Verify product label prior to reconstitution and administration to prevent medication errors.
Other warnings/precautions:
• HER2 expression: Establish HER2 overexpression or gene amplification status prior to treatment; has only been studied in patients with evidence of HER2 overexpression, either as 3+ IHC (Dako Herceptest) or FISH amplification ratio ≥2 (Dako HER2 FISH pharmDx test). There is only limited data on patients with breast cancer positive by FISH and 0 or 1+ by IHC.
Monitoring Parameters
Platelet count (at baseline and prior to each dose), transaminases and bilirubin (at baseline and prior to each dose); verify pregnancy status prior to treatment initiation; HER2 expression status. Evaluate left ventricular function (prior to and at least every 3 months during treatment; for LVEF <40% or 40% to 45% with ≥10% absolute decrease below baseline value, reassess within 3 weeks). Monitor infusion site during infusion for possible infiltration; monitor for infusion reactions (during infusion and for 90 minutes after initial infusion and for 30 minutes after subsequent infusions); signs and symptoms of bleeding, neuropathy, and/or pulmonary toxicity
Pregnancy Considerations
Animal reproduction studies have not been conducted. [US Boxed Warning]: Exposure to ado-trastuzumab emtansine during pregnancy may cause embryo-fetal harm. Effective contraception must be used in women of reproductive potential. Oligohydramnios and oligohydramnios sequence (manifested as pulmonary hypoplasia, skeletal malformations and neonatal death) were observed following trastuzumab exposure during pregnancy (trastuzumab is the antibody component of ado-trastuzumab emtansine). Monitor for oligohydramnios if trastuzumab exposure occurs during pregnancy or within 7 months prior to conception; conduct appropriate fetal testing if oligohydramnios occurs. Based on the mechanism of action, the DM1 component of the ado-trastuzumab emtansine formulation may also cause fetal harm if administered during pregnancy. Verify pregnancy status (in females of reproductive potential) prior to therapy. Effective contraception is recommended during therapy and for 7 months after the last dose for women of childbearing potential. Males with female partners of reproductive potential should use effective contraception during therapy and for 4 months after the last dose. Ado-trastuzumab emtansine may impair fertility in females and males.
If ado-trastuzumab emtansine exposure occurs during pregnancy or within 7 months prior to conception, healthcare providers should report the exposure to the Genentech Adverse Event Line (888-835-2555). Women exposed to ado-trastuzumab emtansine during pregnancy or within 7 months prior to conception are encouraged to enroll in MotHER Pregnancy Registry (1-800-690-6720).
European Society for Medical Oncology (ESMO) guidelines for cancer during pregnancy recommend delaying treatment with HER-2 targeted agents until after delivery in pregnant patients with HER-2 positive disease (Peccatori 2013).
Patient Education
• Discuss specific use of drug and side effects with patient as it relates to treatment. (HCAHPS: During this hospital stay, were you given any medicine that you had not taken before? Before giving you any new medicine, how often did hospital staff tell you what the medicine was for? How often did hospital staff describe possible side effects in a way you could understand?)
• Patient may experience dry mouth, change in taste, abdominal pain, nausea, vomiting, diarrhea, constipation, muscle pain, joint pain, headache, nosebleed, dizziness, mouth irritation, insomnia, or rash. Have patient report immediately to prescriber signs of infusion reaction, signs of liver problems (dark urine, fatigue, lack of appetite, nausea, abdominal pain, light-colored stools, vomiting, or jaundice), signs of heart problems (cough or shortness of breath that is new or worse, swelling of the ankles or legs, abnormal heartbeat, weight gain of more than five pounds in 24 hours, dizziness, or passing out), signs of infection, signs of bleeding (vomiting blood or vomit that looks like coffee grounds; coughing up blood; hematuria; black, red, or tarry stools; bleeding from the gums; abnormal vaginal bleeding; bruises without a reason or that get bigger; or any severe or persistent bleeding), burning or numbness feeling, severe injection site pain, burning, edema, or irritation, severe loss of strength and energy, swelling of arms or legs, signs of low potassium (muscle pain or weakness, muscle cramps, or an abnormal headache), or signs of a severe pulmonary disorder (lung or breathing problems like difficulty breathing, shortness of breath, or a cough that is new or worse) (HCAHPS).
• Educate patient about signs of a significant reaction (eg, wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat). Note: This is not a comprehensive list of all side effects. Patient should consult prescriber for additional questions.
Intended Use and Disclaimer: Should not be printed and given to patients. This information is intended to serve as a concise initial reference for health care professionals to use when discussing medications with a patient. You must ultimately rely on your own discretion, experience, and judgment in diagnosing, treating, and advising patients.
More about ado-trastuzumab emtansine
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- Drug class: HER2 inhibitors
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Other brands: Kadcyla


text: A Spring in Your Step… April 2, 2016 ~ MyListUAE ~ Leave a comment Spring is well and truly here and we couldn't be happier! The season when flowers bloom, birds sing and nature rejoices. What better inspiration for your home than everyone's favourite season? At MyList, we have shortlisted our most cherished spring essentials which you just can't afford to miss. Continue reading → Rate this:


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Lady Day Sings the Blues (at EmersonŌĆÖs Bar and Grill)
Alexis J. Roston stars as Billie Holiday in Milwaukee Rep production
Billie Holiday didnŌĆÖt sing with the intimidating virtuosity of Ella Fitzgerald, but with an intimacy that continues to speak directly to listeners a century after her birth. Singing mostly about romance and sex, Holiday brought heartfelt experience to lyrics that could have sounded trite in the mouths of others. Her posthumous fame is sustained as much by her story as her music, especially the tragedy of the heroin addiction that sapped her strength, and her death in a Harlem hospital, her room raided by police who arrested her after finding a tinfoil packet of heroin. She died in that room in 1959, age 44.
Little wonder her life and the music that was inseparable from it inspired a popular movie, Lady Sings the Blues, and later a stage play, Lady Day at EmersonŌĆÖs Bar and Grill. Playwright Lanie RobertsonŌĆÖs Lady Day returns to the Milwaukee Repertory Theater this month with Alexis J. Roston, previously seen in the RepŌĆÖs rendition of The Color Purple, in the lead role. Roston comes to the part well prepared after starring in an award-winning production of Lady Day at ChicagoŌĆÖs Porchlight Music Theatre.
For Lady DayŌĆÖs Milwaukee Rep director, Leda Hoffman, the show is not a musical revue but ŌĆ£a full piece of theater with a full story to tellŌĆöthe text is interwoven seamlessly into the songs.ŌĆØ Although still best known for directing King Lear at Alchemist Theatre and her work at Shakespeare festivals around the Midwest, Hoffman sought the challenge of helming a play with music and was drawn to HolidayŌĆÖs recordings. ŌĆ£She was known for telling a story through her songs,ŌĆØ Hoffman says. ŌĆ£The lyrics were real to herŌĆöshe sang deeply from what was in her heart, connecting what was in the song with the audience. Honesty in performance is important to me as a director.ŌĆØ
Although Lady Day is a fictionalized recreation of a performance from the final months of HolidayŌĆÖs life, the play is rooted in reality. Holiday actually sang at EmersonŌĆÖs, a seen-better-days bar in Philadelphia that becomes a metaphor for a singer in decline following her triumphant Carnegie Hall concert only a few years earlier. ŌĆ£You see a woman whose prime of life is past as her addiction and health problems pile up,ŌĆØ Hoffman says. ŌĆ£SheŌĆÖs aware of the strain on her body. Lady Day includes incredibly hopeful moments, but Billie Holiday is aware of what sheŌĆÖs lost.ŌĆØ
Lady DayŌĆÖs second character is HolidayŌĆÖs accompanist, a fictional piano player called Jimmy. ŌĆ£Jimmy is her rock. She knows she needs Jimmy to keep her on track,ŌĆØ Hoffman says. ŌĆ£Jimmy cares deeply about her as an artist. There is a struggle between the two of them as they figure out how they will make it through the performance.ŌĆØ Lady DayŌĆÖs music director, Abdul Hamid Royal, plays Jimmy.
In between ŌĆ£God Bless the Child,ŌĆØ ŌĆ£What a Little Moonlight Can DoŌĆØ and other songs associated with HolidayŌĆÖs career, the singer flashes back into her past. ŌĆ£One of the exciting challenges about the play is figuring out how to dive into HolidayŌĆÖs stories and memories,ŌĆØ Hoffman says. ŌĆ£Our design team takes it a step further than the songbook of a legendary singer, using light and sound to take us to emotional places different than what would literally be happening at EmersonŌĆÖs Bar and Grill.ŌĆØ
As for casting the new production of Lady Day, Hoffman skipped the usual audition process and went to Rep veteran Royal (ŌĆ£everyone was talking about what an incredible piano player he wasŌĆØ) and straight to Roston after her buzz-generating turn as Holiday at ChicagoŌĆÖs Porchlight. ŌĆ£I watched videos of her performance and said, ŌĆśThis is the person,ŌĆÖŌĆØ Hoffman explains. ŌĆ£ItŌĆÖs so important to have a great performer at the center of this play. She had put so much work and thought into her performance as Billie Holiday and was excited to look at the material again.ŌĆØ
The Milwaukee Repertory Theater presents Lady Day at EmersonŌĆÖs Bar and Grill, Sept. 9-Oct. 30 at the Stackner Cabaret, 108 E. Wells St. For tickets, visit the box office or milwaukeerep.com or call 414-224-9490.


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wger Workout Manager is a Web application that can manage your workouts, group them into schedules (A>B>C), and export them as PDFs or iCal files. It helps you keep a log of the weights lifted in the different exercises as well as your own body weight and can also create and manage your diet plans.
Libgta implements the Generic Tagged Arrays (GTA) file format. GTAs can store any kind of data in multidimensional arrays, optionally with simple tags to store rich metadata. GTAs are streamable and support mupltiple compression methods. Uncompressed GTAs allow easy out-of-core data access for very large arrays.
mpop is a small, fast, and portable POP3 client. Its features include header-based email filtering (filter junk mail before downloading it), delivery to mbox files, maildir folders, or a mail delivery agent, a very fast POP3 implementation, many authentication methods, and good support for TLS/SSL.
msmtp is an SMTP client with a sendmail compatible interface. It can be used with Mutt and other MUAs. It forwards messages to an SMTP server which does the delivery. Features include various SMTP AUTH methods, TLS/SSL-encrypted connections (including support for client certificates), support for multiple accounts, DSN, and IPv6 support.
The Intel Software Development Emulator is a functional emulator for new and upcoming instruction set extensions. The emulator is based on the Pin dynamic binary instrumentation system (and XED). It emulates the new instructions in the SSE4, AES, PCLMULQDQ, and RTM, BMI1, and BMI2 Intel AVX, AVX2, and AVX512 instruction set extensions. This allows developers to gain familiarity with Intel's upcoming instruction set extensions.
CCruncher is a project for quantifying portfolio credit risk using the copula approach. It is a framework consisting of two elements: a technical document that explains the theory, and a software program that implements it. CCruncher evaluates the portfolio credit risk by sampling the portfolio loss distribution and computing the Expected Loss (EL), Value at Risk (VaR), and Expected Shortfall (ES) statistics. The portfolio losses are obtained simulating the default times of obligors and simulating the EADs and LGDs of their assets.
P* (P-star) is a Web programming language that incorporates common tasks like template handling and database queries into the language. It features MySQL database access with prepared statements, HTML templates, standard arithmetic and variables, functions, structs, (to-be-classes), JSON output, and GET and POST. Programs can be run on the command line, in a CGI environment, or by the P* Apache Module.
A company administration manager.
A Magento script for online bookings.


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The correct coolant is any permanent, high quality ethylene glycol antifreeze mixed in a 50/50 concentration with water. This mixture gives the best combination of antifreeze and anti-boil characteristics within the engine.
It's best to check the coolant level when the engine is COLD. The radiator coolant level should be between the LOW and the FULL lines on the reservoir tank when the engine is cold. If low, check for leakage and add coolant up to the FULL line but do not overfill.
Check the freeze protection rating of the antifreeze at least once a year or as necessary with a suitable antifreeze tester.


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Vahine Tahiti Drum Beat Demonstration MP3
Vahine Tahiti drum beat demonstrated at a slow pace.
Otea rumia MP3
Tahitian drum beat.
"BoraBora" Drum Beats MP3
"BoraBora" Drum Beats.
jungle MP3
Tahitian Music song: Jungle by: Last Voices.
Jungle Drum Tahitian Dancers MP3
Hula dancing, Tahitian dancing, Hawaiian dancing, Tamure. Dance is a real mixture of Maori and Tahitian/Cook Island drums.
Cook Island Drum Beat . MP3
Pulsating beat of Tahitian drums MP3
In the island of Tahiti, beautiful women dance to the exciting & pulsating beat of Tahitian drums. Hawaiin Pacific Magic covers the cultural events from locally, ...
Haere Mai MP3
Rythme polynésien! Source: Chanson - (?) Photo Spectacle - Tahiti Ora.
Jungle - Last Voices MP3
Album: Siva Pacifica. (If the song sounds fuzzy, just refresh the page)
CELEBRITY SOLSTICE TAHITIAN DRUM DANCE in PAPEETE HD 1080p MP3
An award winning Tahitian folkoric dance group will take you on an imaginary voyage of Tahiti's rich cultural background through native song, dance, and music ...
Tahitian Drums MP3
Provided to YouTube by DashGo Tahitian Drums · Pulefano and the Polynesians Authentic Polynesia, Vol. 2: Various Islands ℗ 1998 Sonoton / APM Music ...
Drum Beats Australia - Awesome Corporate Drumming Events! MP3
www.drumbeats.com.au, Dynamic Corporate Drumming & Team Building Activities, Australia Wide, Call Us Today at 1300 749 846 or Visit: Drum Beats 309 ...
Festival Drum Beats MP3
Provided to YouTube by CDBaby Festival Drum Beats · Dandin Ranillo Fiesta ℗ 2011 DANDIN RANILLO Released on: 2011-02-01 Auto-generated by ...
J Holiday Bed Island Drum beat MixXx MP3
Miss Sokopeti produxXxionz!
Tahitian Drums-Lucky Star MP3
Provided to YouTube by The Orchard Enterprises Tahitian Drums-Lucky Star · Native Tahitian Singers Mutiny on the Bounty (O.S.T - 1962) ℗ 2013 Vintage ...
Me dance to tahitian drum and waka waka. MP3
Dance at the ministry of science sport day event.
islands - winged beat drums MP3
not mine but pls enjoy.
Authentic Tahitian Drum Medley - Amoni / Pahu / Moorea MP3
Provided to YouTube by The Orchard Enterprises Authentic Tahitian Drum Medley - Amoni / Pahu / Moorea · Gaston Guilbert Lost Island Songs ℗ 2013 ...
Drums of Rarotonga track 4 MP3
Traditional log drumming recorded live.
Ho'oponopono, Mantra Meditation, Hawaiian Prayer, Theta Binaural Beats, Hooponopono MP3
MP3 download available here :) http://www.relaxmeonline.com/relaxation-music/affirmations/ CD Available here at my Ebay store: ...


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Let us know when your receive great advice so we can thank our lawyers and point others with similar questions in the right direction.Got it!
I am being sent a wrongful death settlement agreement form to sign along with my 2 siblings. We are to say how each one of us should like to have the proceeds of this wrongful death case divided among ourselves. At one point we were all talking, and agreed 1/3 each. Now that we are not talking, I don't know how to sign. I know If we all don't agree it could tie it up in court for a long time. I was told California was state that divides up among each of us. I have no idea how this all works, not sure each one of us had a very close relationship with deceased, but does the firm have the right to determine or if it is all 3 of us who decide how do we know what the other is deciding if no one will talk to the other.
You each need to have a conversation with your attorney. Ultimately it is up to you to decide how the proceeds should be split. If you can't agree, there is a possibility that the money could be held until a court decides. It would be best for all of you to figure it out amongst yourselves. Best of luck.
I am licensed in California, therefore, my answers are based on general prinicpals of law or California law, which may not be applicable in your jurisdiction. Answers posted to Avvo are for general information only. Do not conclusively rely on any information posted online when deciding what to do about your case. Every case depends is fact dependent, and responses are limited to and is based on the information you posted. No attorney-client relationship shall be created through the use reading of this response on Avvo. You should never delay seeking legal advice, disregard legal advice, or commence or discontinue any legal action because of information in this response.Ask a similar question
Best bet is to have the lawyer contact the siblings since you are not talking with one another. Make sure you don't sign the settlement agreement unless you agree to the fee and costs being deducted. Many lawyers take large and unreasonable fees and bill the costs to their clients instead of taking the costs from their portion.
Only 29% Contingency Fee! Phone: 215-510-6755 www.InjuryLawyerPhiladelphia.comAsk a similar question
They already are getting 40%. Do they bill differently because of this process
I would recommend using the attorney handling the case as an intermediary. If the communication has ceased between you and the members of your family, the attorney will be able to bridge that gap and educate you on the best course of action.
Ilya D. Frangos, Esq.
Law Offices of Galine, Frye, & Fitting
411 Borel Ave., Suite 500
San Mateo, Ca 94402
Phone: 650-345-8484
Fax: 650-345-9875
Please be advised that my responses to questions on Avvo are meant for informational purposes ONLY and do not create any type of attorney-client relationship or preserve any rights and statutes relating to the individual claim.Ask a similar question
If the matter were to proceed to trial, the jury would evaluate the extent of each claimant's damages separately, which is based generally on the loss of love, affection and companionship of the deceased. If there is limited insurance money, it would be divided in proportion to the damages award. In trying to reach a settlement, an equal division is usually the easiest agreement to make until one claimant decides they are entitled to more. Sometimes these claims can be resolved at a mediation. If you are represented, speak to your attorney about the best strategy. If you are not represented and there is not agreement as to proportional shares, you will need to talk to a personal injury attorney.
Good luck.Ask a similar question
i agree with the other counsel's responses
Legal disclaimer:This message does not constitute legal advice and does not create an attorney-client relationship. Any statements are made for general informational purposes and do not constitute legal advice. No attorney-client privilege is created by this communication. Attorney is licensed in California only.Ask a similar question
If the siblings are the only beneficiaries then I suggest that they should all get one third with the proviso that if one of the siblings stayed with the parent an inordinate amount of time and lost wages as a result of the incident, then that sibling should be made whole and then the rest of the money should be split equally. There are many other ways, such as let the poorest of the sibling take the largest share, but each family is different, so in the end it is up to each one of you to instruct your lawyer what your position is and to submit it to the lead lawyer. Best of luck.
This answer is provided by Manuel A. Juarez, Esq., El Abogado de Accidentes de Autos de California: 510-206-4492. El Abogado de Accidentes de Autos provides answers of a general context. These answers are not intended to form an attorney client relationship. El abogado de Accidentes de Autos y Lesiones Personales is licensed only in California. This information is good only in California and it is not to be taken as legal advice on car accidents, personal injury, divorce, bankruptcy or in any other type of situation. Esta respuesta es del Abogado de Accidentes de Autos y Lesiones Personales de Acidentes de carros, Manuel A. Juárez, 510-206-4492. Abogado Hispano de Accidentes, Divorcios, Abogado Latino de Accidentes, y Abogado de Acidentes de Oakland, Hayward, San Francisco, y California. Estas respuesta son solo para información general y no consisten en consejo legal sobre divorcios, mantención de esposas, mantención de hijos o bancarrotas. Las respuestas son comentarios legales que no forman una relación de abogado y cliente. Manuel Juarez, Esq., esta licenciado solo en el Estado de California.Ask a similar question
If you all cant agree, the atty should get all to agree to a binding arbitrator to hear each childs claim and determine the value. Then the arbitrator will allocate pro rata based on the relative value assigned to each party. All should share in arbitrator's costs.Ask a similar question
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text:
- shaley
- adjective see shale
New Collegiate Dictionary. 2001.
New Collegiate Dictionary. 2001.
shaley — shale ► NOUN ▪ soft stratified sedimentary rock formed from consolidated mud or clay. DERIVATIVES shaly (also shaley) adjective. ORIGIN probably from German Schale … English terms dictionary
shaley — See shale. * * * … Universalium
shaley — adjective Pertaining to or resembling shale … Wiktionary
shaley — 1) halsey 2) ashley … Anagrams dictionary
shaley — variant of shaly … Useful english dictionary
Shaley Scott — (born Melanie Pedersen) is an upcoming singer/songwriter/actress who has recently landed roles in 5 movies. A self taught musician and trained dancer, Shaley grew up in Fort Collins, Colorado, graduating from Rocky Mountain High School. She… … Wikipedia
Shaley House — (Dinner Plain,Австралия) Категория отеля: Адрес: Snow Gums Lane, 3898 Dinner Plain, Ав … Каталог отелей
skerry — shaley, of the nature of slate. Derb. Spoken of coals … A glossary of provincial and local words used in England
Silurian Period — Interval of geologic time, 443–417 million years ago. The third period of the Paleozoic Era, the Silurian follows the Ordovician Period and precedes the Devonian. It marks the first appearance of land plants and jawed fishes. The continents were… … Universalium
Kiritsugu Emiya — nihongo|Kiritsugu Emiya|衛宮切嗣|Emiya Kiritsugu is a character from the Japanese visual novel and anime series Fate/stay night by TYPE MOON.Kiritsugu saved Emiya Shirō during the aftermath of the Fourth Holy Grail War in Fuyuki City, later becoming… … Wikipedia


text:
Kuwaiti Oil Fires: Regional Environmental Perspectives Ebook
Regional Environmental Perspectives: Regional Environmental Perspectives
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Just before the end of the 1990-1991 Gulf War, more than 700 wells in Kuwaiti oil fields were set on fire. Several international companies and scientific organisations were involved in extinguishing the fires and in assessing the impact of this major environmental incursion. Kuwaiti Oil Fires: Regional Environmental Perspectives summarises these effects. The topics covered include the application of remote sensing techniques to determine the location of wells on fire and plume movement; air quality and particulate monitoring by ground stations and aircraft measurements; organic and inorganic constituents in the air; use of modeling techniques to study dispersion characteristics of pollutants and deposition of soot; and the efforts by the fire fighters in extinguishing fires and capping the wells. A brief overview of the causes of the crisis and the role of regional and international groups in resolving the dispute is presented as well as some basic and useful statistics of the region covering general information on economic aspects and exploitation of oil resources in both Iraq and Kuwait. Problems faced by the fire fighting teams, the preparations made to overcome the problems, and technology used in extinguishing the well fires are also discussed. Numerous colour photographs are used to illustrate the problems encountered and the techniques involved in their solution.
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text: By request30 USD per guestSan's kitchen6 USD per guestSnarky Kitchen18 USD per guestVegan/Vegetarian Venue in the PNW15 USD per guestMay's Authentic Asian kitchen24 USD per guestThe Culture Club presents: Sharing Food. Sharing Stories.40 USD per guestLa Madera Supper Club24 USD per guestIn Search of Umami24 USD per guestSear24 USD per guestRooted Kitchen24 USD per guestTandem24 USD per guestMediterranean in NYC18 USD per guestSunday Brunch Sampler in AstoriaQueensEuropeanI began cooking around 1987 and have since become a self-described 'foodie'. ;-)


text:
People of the East
By: Edeara,Jaden,Isaiah,and Ayden
This word cloud explains the main idea of the poster.
The eastern Indians hunted deer, bears, and rabbits
They also farmed . they planted farms between the tree stumps.Corn, beans ,and squash
A longhouse was a large house made with wood poles and bark. Families lived in them and lit fires for cooking and warmth.
A confederation is a type of government in which separate groups of people join together, but local leaders still make most decisions for their group.
A wampum is a belt made of pieces of carefully shaped and cut seashell. American Indians strung the shells like beads.
Barter , they trade goods without using money .


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This driver was downloaded from realtek.com. they support procomp/ avance (als).check the sound card for a chip with an als200 identification. this exe unzips to a folder of your choice. when w98 finds the device, point to that folder. e a s y install.
|Discussion Thread
|Procomp celerom (Windows XP Professional) [IDE] 1 reply
|Aug 16, 2007


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What is JotForm?
JotForm is a free online form builder which helps you create online forms without writing a single line of code. No sign-up required.
At JotForm, we want to make sure that you're getting the online form builder help that you need. Our friendly customer support team is available 24/7.
We believe that if one user has a question, there could be more users who may have the same question. This is why many of our support forum threads are public and available to be searched and viewed. If you'd like help immediately, feel free to search for a similar question, or submit your question or concern.
Printing and Saving Form as PDF is not workingAsked by Brandonsplace on October 31, 2014 at 04:16 PM
When I attempt to print or save as a pdf any of the forms in my account, I get an error message that says "print preview failed." I don't have issues to printing anything else from my computer or from any other website. I work on a Dell and use Chrome for my browser with Windows 8 as my OS. My boss also uses Jotform and has no problem printing...she has a MacBook Pro. Please help.
JotForm Support
Hi Samantha,
Please review this user guide https://www.jotform.com/help/212-How-to-Create-a-PDF-Form
Are you saying that you could not saved the form as PDF file format even when following the steps on the user guide I provided?
This sceenshot shows how it can be done
I also checked the jotform in your account and noted that they do not have Print button on them, example http://www.jotform.us/form/42847602291153. So think you are not referring to that print button.
Please inform us if the issue persist.
It will also help us understand better if you can provide more clarity on the steps you have taken to reproduce the issue.


text:
Luli Fama Desert Babe Bikini Bottom - Black
luli fama
82.00Size Chart
The Black Desert Babe bikini bottom by Luli Fama is gorgeous. The gold and black mesh overlays and solid black contrast makes this bikini bottom look glamourous. The bottoms feel silky to the touch and has full coverage. Match it with any Desert Babe bikini top for your next trip to the beach.
- Gold and black bikini bottom
- Glamourous mesh overlays
- Solid black accents
- Full coverage
- Low rise


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Each month, Rated People connects over 50,000 homeowners with quality tradesmen - simply enter your job details in the form above to get started.
We'll match your job to the relevant tradesmen in your area - those interested will pay to see your contact details and call you to quote.
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looking for a tradesman for damp proofing to the external front wall of the property and internally...
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I need someone to mount a television on my wall
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Top guy, very punctual and competitive quote. Worked to a very tight schedule. Employed for a second job- rendering outside walls. Couldn't be more helpful.
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HEARD the one about the comedian who decided to get back to a love of acting?
Toby Hadoke is one of the country's most in-demand stand-ups having toured three one-man shows, played in the West End and is the regular compere for three top comedy clubs.
But next week, he will be in Blackburn, in a very different role - in John Godber's April in Paris which runs for three nights at the Thwaites Empire Theatre.
The play is a two-hander in which Toby plays Al, an out of work builder, and Sarah Burrill is his wife, Bet. She's an avid competition fan and wins the pair of them a break in Paris.
"They are living this humdrum existence when she wins the holiday," said Sarah. "Their relationship has stagnated really but the break is a chance for them to get to know each other and rekindle the romance."
Toby, who runs the XS Malarkey comedy club in Manchester, made a conscious decision to get back into acting with this play.
"I realised in December last year I'd been a professional comedian for 21 years," he said, "which is a long time seeing as I got into it by mistake. But time flies when you don't know what you are doing!
"Comedy is meritocracy so if you're half decent you'll get work and I've always been able to get work thank goodness but I've always been an actor at heart.
"I've kept my hand in doing radio but I'd sort of lost sight of it.
"I've toured three one man shows, I've taken them to the West End and on to the radio but I missed acting with other people which is what I was supposed to be doing 21 years ago but forgot."
Sarah, who also runs the Little Diamond Theatre Company, which is staging the play, said Toby was a delight to work with.
"It would be a total disservice to think he's only here for the comedy," she said. "He's a really good actor and can do the tender stuff equally well. It's a great contrast. He's a joy to work with."
Toby said that quality of the writing was one thing which attracted him to the play.
"John Godber has this knack of appearing to make things look deceptively simple," he said. "He's very spare in his writing and what looks like a throwaway line actually has a lot to it when you consider it.
"The play and its themes are surprisingly relevant seeing it was written in 1992.
"Al is very much a broken man at the start of the play - it's a brilliant portrait."
April in Paris is both moving and very funny and, Sarah, said, is a play which will resonate with everyone in the audience.
Toby, used to performing alone on stage, has had to adapt to the extra discipline required for theatre.
"When I'm compering I usually make it up anyway," he said. "But with this, if I make a mistake I'm landing Sarah in it. So I have to be much more disciplined.
"You can't be quite so blase about things when other people are relying on you."
April in Paris, Thwaites Empire Theatre, Blackburn, Tuesday, March 21 to Thursday, March 23. Details from 01254 685500


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Our Lady crowned decalcomania, religious sticker depicting Our Lady with a crown on her head.
Sticker size 10.5x30 cm (4.13x11.81 in). This decalcomania is made using high quality light-proof colors and it is treated against scratches. Easy to stick and remove.
- Model: VF000005
- Shipping Weight: 0.05Kg
- Materials: plastic
- Origin: Italy
- MEASURESUnits:
- Height: 30 cm
- Width: 10.5 cm
- MEASURESUnits:
- Height: 11.81 in
- Width: 4.13 in


text:
Just discovered Game-icons.net and it is so wonderful.
Search for icons by category on the right (Symbol, Action, Machine, etc).
Icons are provided for use under the Creative Commons 3.0 BY License.
If your browser can handle it you can see a full preview of most (all?) of their icons in one sheet here: http://game-icons.net/images/montages/game-icons.net.png
Be warned, it takes a while to load o_O


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Hanfeizi was a prince of the Warring States and part of the royal family of Han.He believed that in order to create a strong society you can not trust anyone not even family."It is dangerous for a ruler to trust others. He who trusts others can be manipulated by others." This shows he didn't even trust his family. another he would have ruled is to have strict laws and never change them. "When you hear any statements made, do not alter or shift them. Just compare them with the actions, and observe whether the statements and actions correspond with each other." He really did not care if the rules were very strict all you do is follow them and you are good to go. Legalism is very harsh i would know from personal experience ( my classroom) and all you have to do is follow them.
Criticizing the government
The image above shows to women whispering/criticizing the government. According to Legalism if these women were caught doing so they shall be severely punished or put to death."People caught criticizing the government should be banished to China's northern frontier." Since people were forbidden to criticize the government they shall be thrown out of China. Rulers did so because they want all power to rule!
The image above represents that Hanfeizi will punish you harsher than he will reward you for telling the truth."Fa means law. This subject means that the ruler should consider that all people are equal before the law. The public should know the law codes clearly. Therefore, it should be written. The people who disobey the law should be punished." This quote shows that if you want to be reward than punished you need to follow the laws and you will be treated like an equal.
Not only did this bring Hanfeizi to the strict laws and punishments, he wanted absolute power. "The intelligent sovereign offers rewards that may be earned, and establishes punishments that should be avoided.
The seven tacts [a sovereign should use] are:
1. Comparing and inspecting all available different theories
2. Making punishment definite and authority clear
3. Bestowing rewards faithfully and everybody exert his ability
4. Listening to all sides of every story and holding every speaker responsible for it
5. Issuing spurious edicts and making pretentious appointments
6. Inquiring into cases by manipulating different information
7. Inverting words and reversing tasks."
Hanfeizi used these seven acts to know how to rule and gain the absolute power he needs to gain victory and kingship.


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Poached Pears in Cranberry Syrup
Be the first to review
READY IN: 40mins
Recipe by southern chef in lo
A very simple but elegant dessert that is sure to impress.
See Discussion:
Ingredients Nutrition
- 4 cups cranberry juice
- 1 cup light corn syrup
- 8 slices unpeeled fresh ginger (1/4 inch thick)
- 2 cinnamon sticks (2 to 3 inches)
- 8 slightly under ripe pears (with stems attached)
Directions See How It's Made
- In heavy 4-quart pan combine juice, corn syrup, ginger, and cinnamon sticks.
- Bring to a boil over medium-high heat.
- Peel pears, leaving stems attached.
- Add to cranberry liquid; cover.
- Reduce heat and simmer 15 to 20 minutes or until the pears are tender.
- With slotted spoon, transfer pears to shallow serving dish.
- Remove the ginger and cinnamon; discard all but 2 cups of syrup. In saucepan, bring to a boil; boil 10 to 12 minutes or until syrup thickens slightly.
- Spoon sauce over pears.


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Something I have in common with Theodore Roosevelt is that he, like I, could be a perfectly miserable shot on antelope.
Once upon a time, I, like he, could admit, "I had thus bagged one prong-buck, as the net outcome of the expenditure of 14 cartridges. This was certainly not good shooting … ," which is a bully understatement.
The difference, of course, is that Roosevelt was likely shooting a Winchester 1886 .45-90 with iron sights and a trajectory like a dying swan. I won't say what I was shooting when I, yes, once missed a 'lope with 14 cartridges over the course of a multi-hour chase; but it was definitely a step up, ballistically.
For some reason, antelope seem to invite poor shooting, which is a shame for such an amazing creature. Emblematic of Wyoming, it is literally the most singular big-game animal in North America.
"The antelope is a queer-looking rather than a beautiful animal," Roosevelt wrote in 1885, noting its "curious pronged horns, great bulging eyes, and strange bridle-like marks and bands on the face and throat."
These he judged "more striking, but less handsome, than the delicate head and branching antlers of a deer; and it entirely lacks the latter animal's grace of movement." And he further faulted "its form and look, when standing still," for being "rather angular and goat-like, and its movements merely have the charm that comes from lightness, speed and agility," as if that were not enough.
Speed and agility hardly sum up the pronghorn's prowess. Antilocapra americana forms the totality of not only its own genus, but its own family, the antilocapridae, occupying, according to the biologists, "a unique and uncertain taxonomic position between deer and bovids."
Unlike so many other large North American mammals that are ultimately Eurasian in origin (elk, moose, sheep), the pronghorn evolved entirely on this continent, being whittled into shape and swiftness by thousands of years of pursuit by an extinct American cheetah. Today, it is still looking over its shoulder for the ghost of that sprinting cat, making it far faster than it has any reason to be, easily able to outclass any extant predator in not only velocity but stamina.
The pronghorn is entirely built for long-distance speed, and its high-performance features are almost too many to list — extremely large heart, lungs, and liver and significantly greater quantities of red blood and hemoglobin than similarly sized animals; oversized windpipe for turbo charging; special built-in "heat exchangers;" dowel-thin legs (why they don't jump); ingeniously engineered skeletal structure; and legendary eyesight. Race a thoroughbred against a pronghorn over a measured mile-and-a-half, and the horse is only hitting the quarter pole when the pronghorn's dust has already settled over the finish line.
This is why pronghorns are often so badly treated.
Hunters will shoot too far at pronghorn moving too fast and the best that can come out of that is a near miss.
The worst is a wounded antelope that may have to be tracked for miles.
The fact is that the pronghorn is, pound for pound, one of the toughest animals in North America to kill.
On three legs it can probably cover twice as much ground as a mule deer can on four.
This is also what gives rise to the canard of antelope meat being poor fare. If a milk-fed veal calf ran two miles on an 85-degree day before being captured and killed, then partially dressed, thrown into the back of a pickup with its hide on, driven around for the rest of the day before being hung up, skinned and cooled, it wouldn't be much on the plate, either.
The gift of the pronghorn, the most "Wyoming" of Wyoming big game, should not be abused.
So here are a few suggestions for the coming season, if I may.
First, pick a good, flat-shooting rifle and cartridge and mount a good scope. Then, practice, practice, practice.
Never succumb to the idea that there is any pronghorn that cannot be stalked, or certainly gotten a lot closer to.
Take your time. Use the features of the terrain to screen your approach. Get into position and find a solid rest before you pull the trigger.
When the antelope is taken, dress out everything from the windpipe down. If you'll be a while getting it to a cool, shady spot to skin, have some milk jugs filled with frozen water and put them in the body cavity to chill it.
Finally, show respect to the pronghorn.
It's the only one we've got.
Tom McIntyre is a contributing editor to Sports Afield and Field & Stream magazine.


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I dreamed hearing that there was a big fire in a trailer and nobody escaped. But in the opening of my dream it was a third person kind of thing, I think (I can't really remember this part of it. Then I dreamed some other stuff I can't remember. But then there was this play that I was rehearsing in school for. In the play the thing that I remember the most was that I was supposed to kiss this woman. I dreamed that I was ascending a platform that was stretched around the classroom. It was like a big wheelchair rise that went around all four corners of the classroom. Although there wasn't really any reason for it to be there in the first place just a ramp that rose for no apparent reason or purpose. When I got to each corner of the classroom on this ramp I was supposed to do somethingn romantic with the teacher according to the play. Like kissing her on the cheek or going down and kissing her hand. When I got to the final corner I gave her a ring and she got down off of the platform and we rehearsed kissing and making out. We did this for a while. Then the principle came in with an a-student. She gave the suggestion of kissing our cellphones to simulate kissing in the modern era of texting and such. This would mean we didn't have to actually kiss. Then we went back to our seats. the play called for another couple to kiss and they were going to make out when I put my cellphone between them. The guy laughed at my little joke. But then things got really weird. All of a sudden there was this strong unidentified force that took havoc on all of our bodies. This force caused the whole class to fall out of our desks and get pressed against the desks in front of us very strongly. Someone then instructed us to take off our shoes. When we did this we were no longer pressed against the desks in front of us. But were lifted up but then pressed against the right wall. Everyone was pressed there except I started floating all around the room. Like one of those old Microsoft cubes. the scene changed to a kitchen. There was a flame-broil stove in one corner and an elevator shaft in the other corner of the same wall. I observed that people seemed to be dragged out of the flame top stove to the other corner and down the elevator. Almost the whole class was on the one side of the classroom though. I awoke just as I was about to pass into the fire top stove.
Most Helpful Girl
have you been eating anything different, or eating too close to bedtime?00|00|0
Most Helpful Guy
LOL... i read yer dream about it... very interested. just like a movie :) especially this line:
"Then the principle came in with an a-student. She gave the suggestion of kissing our cellphones to simulate kissing in the modern era of texting and such."
i had similar movie-like dreams as well (i wrote a take about one of 'em)... but yet i don't have anything to worry about as long as i know chances r they r not gonna happen in reality. :D
for xample today i saw another nice dream yet kinda weird... i supposed to be a super-hero and i was standin on da top of a skyscraper in order to have a good look-out bout wot's happenin down on da street...
then after some point and after some successful fights against some thugs and common criminals... a gal who has blocked me here (LOL... yeah!) was being attacked by some thugs. i jumped off da skyscraper and appeared in front of em! her reaction was really bad she was like "huh... wot do u want here? and wot r those stupid clothes u wear (i was wearin a cape like a super-hero :p ) ?"
after she said this... i winked at her, and started to attack against those thugs... i knocked 'em out all off em! then she changed and she was like " u r my hero!! u r awesome!!! i'm really sorry for being mad at u!!" then she gave me a hug and i hugged her back. after this scene i threw away my cape and we walked together for some couple of miles till we caught a train passin by.
then da next thing happened was really weird... after da train left i found myself wakin up into a hencoop (a dream within a dream possibly? )... but even weirder thing was hencoop had... CATS instead of hens o_O
when i woke up an old lady came inside and told me "oh u r awake? u've got to feed da cats"... so i did.
i was feedin some cats, till after some mins i woke-up (irl) suddenly coz of some pain on my left leg... a spasm possibly? ew... i wanted this dream to continue... it started to get interestin :(11|00|0


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The Crown Inn
The Square, Bishop's Waltham, SO32 1AF +44 1489876457
- Average
- Main course: £8
- Food spend: £20
- Opening hours
- Monday to Sunday: 08:30 - 23:00.
We were very impressed with the menu, the roast dinner was excellent. We waited a short time for the dessert menu but that was a good thing in the end. The decor is very modern but very tasteful. We will definitely return.
Ann Whettingsteel
26 April 2016
from Fareham
A former 16th-century coaching Inn, The Crown Inn serves gastro pub cuisine. Boasting an authentic coal-fired oven, The Crown Inn pub also features real ales, crackling log fires, and picturesque patio dining.
Showcasing locally sourced ingredients, The Crown Inn menu includes comforting treats like roasted pheasant with creamed flageolet beans, garlic & thyme, along with mussels with leeks, bacon and cider liqueur, and delicious braised Owtons faggots with caramelised sage & onions. The excellent coal-fire menu features a 32-day-aged Chalcroft rib eye steak, mouth-watering barbeque ribs, and an enticing Hampshire trout with horseradish, walnut, crème fraîche, and seasonal vegetables.
Adopting a rustic décor, The Crown Inn in Bishop's Waltham flaunts timber beams, red brick features, and cosy leather banquettes. Embracing its historic setting, The Crown Inn restaurant in Hampshire showcases an intriguing gallery of artwork and vintage ornaments
A quaint Hampshire pub, The Crown Inn restaurant in Southampton is located on the B-2177. Winchester town centre is a 23-minute drive away.
The Crown Inn
The Square, Bishop's Waltham, SO32 1AF
See all Fuller's Pubs
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Customer reviews for The Crown Inn
- Food
- Value
- Ambience
- Location
- Service
- Drinks
((((( 26 April 2016 by Ann Whettingsteel from Fareham
We were very impressed with the menu, the roast dinner was excellent. We waited a short time for the dessert menu but that was a good thing in the end. The decor is very modern but very tasteful. We will definitely return.
((((* 29 March 2016 by Susan Bell from Southampton
Staff very welcoming. Some confusion over what came with what dish so my daughter did not get what she expected, but an attempt was made to rectify this and we were guev free coffees. Food good. Would like desserts to have been home made - if they were this was not noted so had to assume they were bought in frozen then defrosted, but otherwise all good.
(((** 24 December 2015 by Adrian Booth from soberton
the menu and the food was not up to standard i was not impressed service was friendly and ok
((*** 23 December 2015 by Hazel Barnes from Southampton
Booked for the restaurant but we were seated in the bar area without table service. Meals arrived ten minutes apart, Yorkshire puddings were a disaster and the portion sizes were very small.
((((* 21 December 2015 by Derek Marlow from Bishop's Waltham
Limited menu selections but what was served was done very adequately. Good atmosphere. Attentive staff without being intrusive. Pricing about right .
((((* 8 December 2015 by Ann Wake from winchester
Cosy and comfortable, staff very attentive and food very tasty.!
((((* 10 March 2014 by James Duncan from Southampton
Good food in an excellent restaurant!
((((( 10 May 2013 by Chris from Burridge
Very nice lunch, great service
((((* 30 April 2013 by Abigail from Bishops Waltham, United Kingdom
I had only eaten in the bar area before but was blown away by the food in the restaurant. I was in a group of 3 and we were all very impressed with the food.
((*** 18 March 2013 by Out n about from Droxford
Food bland and tasteless. Also luke warm.
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Food and Drink in Malaga
Málaga has no shortage of places to eat and drink, and, though it's hardly a gourmet paradise, the city has a justified reputation for its seafood.
Málaga's greatest claim to fame is undoubtedly its fried fish, acknowledged as the best in Spain. You'll find many fish restaurants grouped around the Alameda, although for some of the very best you need to head out to the suburbs of Pedregalejo and El Palo, served by bus #11 (from the Paseo del Parque). On the seafront paseo at Pedregalejo, almost any of the cafés and restaurants will serve you up terrific fish. Further on, after the paseo disappears, you find yourself amid fishing shacks and smaller, sometimes quite ramshackle, cafés. This is El Palo, an earthier sort of area for the most part, with a beach and fishing huts, and in summer or at weekends an even better place to eat.
Inexpensive restaurants
Cañadu, Plaza de la Merced 21. A rare vegetarian option serving a good selection of salad- and pasta-based dishes accompanied by organic wines and beers.
La Cancela, c/Denis Belgrano 3, off c/Granada. A malagueño institution - ajo blanco (chilled almond soup) is a must here - with an economical ménu and outdoor tables in a pleasant, pedestrianized street.
Mesón de Jamón, Plaza María Guerrero 5, just off the Plaza Merced. Good-value menú and a selection of jamón and cheese tapas.
Restaurante Arcos, Alameda 31. Efficient central place serving all-day platos combinados and late-night meals - for breakfast they also serve pan tostada with wholemeal bread, pan integral .
El Tintero II, El Palo. Right at the far east end of the seafront, just before the Club Náutico (bus #11; ask for "Tintero Dos"), this is a huge beach restaurant where the waiters charge round with plates of fish (all costing the same for a plate) and you shout for, or grab, anything you like. The fish to go for are, above all, mero (a kind of gastronomically evolved cod) and rosada (equally indefinable), along with Andalucian regulars such as boquerones (fresh anchovies), gambas (prawns), calamares, chopos, jibia (different kinds of squid) and sepia (cuttlefish). It certainly isn't haute cuisine but for sheer entertainment it's a must.
El Vegetariano, Pozo del Rey 5, Just north of the Roman Theatre. Atmospheric - maybe too much so for some as smoking is permitted - little veggie place offering a variety of imaginative pasta-, cheese- and salad-based dishes. They have a twin restaurant, El Vegetariano de San Bernardo, at the junction of c/Niño de Guevara and c/Cañuelos de San Bernardo, a couple of blocks west of Plaza de la Merced.
Moderate to expensive restaurants
Al-Yamal, c/Blasco de Garay 3, near Hostal El Cenachero. Good North African restaurant serving up meat in spicy sauces, couscous and other typical Arab food.
Antonio Martín, Paseo Maritimo. One of Málaga's renowned fish restaurants and the traditional (and expensive) haunt of matadores celebrating their successes in the nearby bullring.
Parador Gilbralfaro, Monte Gilbralfaro. Superior dining on the terrace with spectacular views over the coast and town. The menú is excellent value at around ?21. If you can't face the climb, bus #35 heading east along the Paseo del Parque will take you there.
Bars and cafés
A number of traditional bars serve the sweet Málaga wine (Falstaff's "sack"), made from muscatel grapes and dispensed from huge barrels; try it with shellfish at Antigua Casa Guardia, a great old nineteenth-century bar at the corner of c/Pastora, on the Alameda's north side. The new season wine, Pedriot, is incredibly sweet; much more palatable is Seco Añejo, which has matured for a year.
Málaga has plenty of good tapas bars : Gorki, in c/Strachan near the turismo is a popular place at aperitivo time, whilst the diminutive size of the bustling, Orellana at c/Moreno Monroy 5, slightly north, is in inverse proportion to its reputation as one of the best tapas bars in town.
Cheaper and earthier options include La Manchega, c/Marín García 4, off the west side of c/Larios.


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1>3>4>2 wrote:I love writing and editing videos and all that jazz but my god my work ethic is abysmal. I have bursts of creativity and content that I'm happy with then I just stop for some reason. Got a few half made videos and scripts that I didn't get around to finishing. Sucks man.
Same here. Tho I have to say your videos are always well written and enjoyable, I like how you don't go for the typical "IM SO ANGRY ABOUT THINGS FFFFPPPPPBT" bullshit schtick a lot of people go for nowadays to get subs.
But the sheer amount of time it takes to make a decent video means id probably have to give up playing actual videogames in order to make videos about them. Nowadays I pretty much just upload straight gameplay footage but I try to mix it up with modding videos, 60fps videos, and some retro stuff (I have a lot of popular Atari ST videos).
Tho my channel isn't doing too badly considering the effort I put into it. 300+ subs and over 1.6 mil views


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As promised my top 5 songs of all time.
5. Bon Jovi - Always
I think this is a lot of people's fave Bon Jovi song. I was 16 when this song came out and I remember watching the video over and over on MTV. It also reminds me of that years holiday to Lanzarote.
4. Green Day - Good Riddance (time of your life )
I have been a massive fan of Green Day since my teens and managed to see them live in 2005. I think this is their most mainstream song and always make me emotional.
3. Del Shannon - Runaway
I first heard this song featured in a movie as a child and have loved it ever since. It was first released in 1961 and it always makes me think of drive in movie theatres and leather jackets for some reason.
2. U2 - All I Want Is You
I love everything about this song, the vocals are amazing and the lyrics get me every time.
1. The Cranberries - Linger
This song told the story of my life when I was 17. I cringe when I think about it now but I still love the raw emotion and isn't it the story of everyone's life at some point?.
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found a new home!
Plenty of my friends are looking
for one too. Find a pet to adopt.
I am already spayed, up to date with shots, and not good with cats.
Pyewacket, a Colonial Heights Siamese cat was adopted! Here's how you can benefit by looking at adoption as an option to buying a Siamese for sale in Colonial Heights, or seeking a Siamese cat from a breeder in Colonial Heights.


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Give us a call to get our secret deals 1-800-468-3578
Property Location
With a stay at SSG Ramblas Deluxe Apartments in Barcelona (La Rambla), you'll be minutes from Placa Reial and Gran Teatre del Liceu. This apartment is close to Palau de la Musica Catalana and Casa Batllo.
Make yourself at home in one of the 9 air-conditioned rooms featuring kitchenettes with refrigerators and microwaves. Complimentary wireless Internet access keeps you connected, and plasma televisions are provided for your entertainment. Conveniences include safes and coffee/tea makers, and you can also request cribs/infant beds (surcharge).
Business, Other Amenities
Featured amenities include luggage storage and an elevator (lift).
You must present a photo ID when checking in. Your credit card is charged at the time you book. Bed type and smoking preferences are not guaranteed.Your reservation is prepaid and is guaranteed for late arrival. The total charge includes all room charges and taxes, as well as fees for access and booking. Any incidental charges such as parking, phone calls, and room service will be handled directly between you and the property.


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A Lock of John Lennon's Hair Sells for $35,000
Lennon had gotten this particular haircut when filming 'How I Won the War.'
Lennon had gotten this particular haircut when filming 'How I Won the War.'
The third part of the equation that would become the Beatles fell into place on Feb. 6, 1958.
When John Lennon was killed on Dec. 8, 1980, he was in the middle of recording the follow-up to the recently released Double Fantasy.
On Jan. 2, 1969, John Lennon and Yoko Ono's 'Two Virgins' was seized by police because of its controversial cover.
What do you say about a man who words have touched so many people, 35 years ago today this man would be silenced by someone who wanted no more than fame for his actions.
Nothing brings out the best in a songwriter like a partnership with just the right amount of creative tension. Just ask Paul McCartney.
One of rock's most significant moments happened when the teenaged John Lennon met Paul McCartney on July 6, 1957.
Of all the Beatles, John Lennon is the one with the most wayward solo discography.
John Lennon's solo albums are getting the vinyl reissue treatment — and being boxed up for a deluxe package scheduled to arrive in stores on June 9.
By early 1964, the Beatles' upbeat love songs and clean-cut image endeared them to fans around the world.


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Wednesday 7 October 1970
It was Wednesday, under the sign of Libra. The US president was Richard Nixon (Republican).
Famous people born on this day include Daniel Collins and Dwayne Provo.
In that special week of October people in US were listening to Cracklin' Rosie by Neil Diamond.
In UK Tears Of A Clown by Smokey Robinson & The Miracles was in the top 5 hits.
The Baby Maker, directed by James Bridges, was one of the most viewed movies released in 1970
while The Crystal Cave by Mary Stewart was one of the best selling books.
On TV people were watching Die Journalistin.
But much more happened that day: find out below..
You can also have a look at the whole 1970 or at October 07 across the years.
Old Newspapers
Have a look at the old newspapers from 7 October 1970 and get them!
Which were the most popular movies released in the last 30 days ?
TV Series
Which were the most popular TV series released in the last 30 days ?
Find out your future
Get a FREE Numerology report based on the digits of 7 October 1970!
Wish him/her..
Historical Events
Which were the important events of 7 October 1970 ?
Famous Birthdays:
- Daniel Collins: Sydney, NSW -- Canoeist (1996 Olympics).
- Dwayne Provo: Cornerback (New England Patriots).
- Harold Ellis: NBA forward (Denver Nuggets).
- Vaughn Hebron: NFL running back (Denver Broncos - Super Bowl 32).
- Nicole Ari Parker: American actress.
- Nicole Parker: TV Actress
Famous Deaths:
- Alphonse-Marie Parent: Canadian priest, educator and academic executive (Born 1906).
- General Juan José Torres becomes the new President of Bolivia.
- The U.S. Foreign Office announces that renewal of arms sales to Pakistan.
- Soviet author Aleksandr Solzhenitsyn is awarded the Nobel Prize for Literature.
- Vietnam War: In Paris, a Communist delegation rejects U.S. President Richard Nixon's October 7 peace proposal as ampquota maneuver to deceive world opinion.ampquot
Music Charts
Which were the top hits in that special week of October 1970 ?
Top #10 songs in the USA
- Neil Diamond - Cracklin' Rosie
- Jackson 5 - I'll Be There
- Dawn - Candida
- Diana Ross - Ain't No Mountain High Enough
- Free - All Right Now
- Bobby Sherman - Julie, Do Ya Love Me
- Creedence Clearwater Revival - Lookin' Out My Back Door
- Sugarloaf - Green-Eyed Lady
- Carpenters - We've Only Just Begun
- Rare Earth - (I Know) I'm Losing You
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What news were making the headlines those days in October 1970?
- Time: TIME Magazine Cover: Richard Nixon -- Oct. 5, 1970
- SportsIllustrated: Sports Illustrated: no.8198
- Life: Attorney Generals wife Martha Mitchell
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Definition Edit
Access National Agency Check with Inquiries (ANACI) is
|[a] personnel security investigation for access to classified information conducted by the Office of Personnel Management (OPM), combining a national agency check and written inquiries to law enforcement agencies, former employers and supervisors, references, and schools, and a credit check.[1]
Overview Edit
"ANACIs are only conducted on civilian employees and do not apply to military or contractor personnel."[2]


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Product details
The Abru Compact multi-purpose ladder is a versatile, multifunctional model, with 10 positions in one portable package. The ladder is easily foldable for convenient transportation and storage, and its easy click-lock system allows for both versatility and security. Simple 'click-lock' system for easy conversion between all 10 modes. The compact height when closed is a convenient 0.63m (2ft), with a maximum length of 2.3m (7ft 7in) as an extended ladder.
- Features: Compact folded dimensions for easy transportation and storage. Stabiliser bars for added stability. Simple Click-Lock hinge system.
- Additional information: Approximate reach height:2.99m (9ft 8in) based on 1.75m (5ft 9in) as the average reach height of a person.
- Colour: Silver
- Material: Aluminium
- Guarantee: 5 years
- Maximum weight supported: 150kg
- Height when extended: 2.3m
- Industry standards or certification: BS EN131
- Suitable for: Professional and domestic use.
Abru Multi-Purpose Ladder 10 In 1 Compact 272789
£73.49 Online exclusive
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Abru Multi-Purpose Ladder 10 In 1 Compact
Home delivery within 7 days
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