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American Woodcock MP3
The Music of Nature proudly presents "American Woodcock," a video portrait of an American Woodcock giving it's nasal "peent" calls at dusk. Notice the subtle ...
Woodcocks - Worth MP3
The woodcocks. Track 01 worth. A very nice band, and a damn good song!
Woodcock Hunt MP3
If you've ever rambled alongside a midlands creek, through a cane patch, or across a marshy bottom, you might have walked right beside a woodcock and never ...
Baby American Woodcocks-Wild Bird Rehabilitation MP3
An American Woodcock baby was brought to us this evening www.wildbirdrehab.org Overland, Mo.
Rugdejakt / Woodcock Hunting MP3
Rugdejakt med stående fuglehund. Når uværet herjer rypefjellet om vinteren trekker vi ned i lavere fjell med mer skog, for å jakte rugde i november og desember ...
American Woodcock shows off dance moves MP3
Video by Bill Hubick For licensing/usage please contact [email protected] Check out Maryland Biodiversity Project here: ...
Wood Cocks! MP3
I have wood cocks!
Mr WoodCock's Dad MP3
A short clip from the movie "Mr Woodcock" where john farley meets mr woodcock's father.
Woodcocks - Raul MP3
Woodcocks - (1990) Woodcocks Label:Still Sane Records.
American Woodcock Displaying in Maine MP3
A male American Woodcock displaying in the spring. Woodcocks often appear on their breeding grounds while there is still snow on the ground. They do their ...
Woodcock Shooting in Scotland over English Setters. MP3
We join a group of Italian hunters over on the west coast of Scotland who have brought over their fantastic working setters to hunt for woodcock. The weather ...
Woodcocks 3rd Round Win Aka Woodcock's 3 Round Win (1946) MP3
Item title reads - Woodcock's 3 round win. Regal cinema, Hull. Yorkshire. Various shots as George James tries to find boxing gloves big enough to fit him before ...
Woodcock Courtship Flight MP3
At dusk in spring, an American Woodcock announces its presence to females with a distinctive "peent" call on the ground, then bursts into a crazy zig zag flight ...
Lee Savold - Bruce Woodcock II (Highlights) MP3
1950-06-06 White City Stadium, White City, London, United Kingdom.
Churring Nightjars, Roding Woodcocks and Screeching Owls MP3
Nocturnal birds do their thing. Nightjars' eerie churring is best heard starting at 2:15 in the video where we were agonisingly close! (unfortunately, despite getting ...
Kοντόραμφες Μπεκάτσες (Short beak woodcocks) MP3
4/11/14 Δύο μπεκάτσες με κοντά ράμφη βόσκουν σε χωματόδρομο (short beak length woodcocks caught on tape in north Greece 04/11/14)
Vlog #8 - Woodcocks Road Part 2 MP3
Part 2 of 2 of a group ride to Woodcocks Road and State Highway 16.
Woodcocks keep me sane MP3
Woodcocks -- Woodcocks Label: Still Sane Records -- sane 10 Released: 1990 Genre: Rock Style: Country Rock.
Sporting Scene - Introduction to Shooting Woodcock. MP3
www.sporting-scene.com. The Woodcock, known to be one of the most elusive and challenging of all the field game, holds great interest for many sportsmen.
Woodcocks Road - Yes, again! MP3
This time with my new GoPro Hero HD camera.
Woodcock Ko's Renet (1946) MP3
Item title reads - Woodcock ko's Renet. Belle Vue, Manchester. Various shots of Bruce Woodcock and Renet boxing in the European Heavyweight ...
Bruce Woodcock (1946) MP3
Doncaster, Yorkshire. Britain's heavyweight boxing Champion Bruce Woodcock working in railway workshop. Various shots of Bruce Woodcock in training ...
Woodcocks Road, DRZ400SM following Ninja 300 MP3
Me on my DRZ400SM following my friend on his Ninja 300 along Woodcocks road in warkworth. Skip to 6:00 for twisties.
Tom Wood: Cocks and Bulls MP3
Woodcock Roding MP3
Squeaks like a mouse, grunts like a pig, hides in leaf-litter and only flies at night: Woodcock are weird birds that are seldom seen unless you know when and ...
Pro Clubs- Woodcocks real- 2 MP3
DOBLETE DE BECADAS(becasses,woodcocks) MP3
doblete de becadas que dejamos marchar por verlas muy faciles,no todo es matar en la caza de la becada ,el respeto a la becada es muy importante.
NASS crew take on Woodcocks MP3
Filmed using the Mini-DV Cam supplied by Active Components (www.activecomponents.com). Location: Woodcocks Rd, Auckland, New Zealand Bike: 2004 ...
Woodcocks Part 1 MP3


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BIRMINGHAM SHOW: Low volume sports car makers find their niche
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First Tutors: Music helps you to locate a tuba teacher in Cambridgeshire and across the UK. First Tutors: Music profiles Cambridgeshire tuba tutors and others offering popular instruments like piano, violin and guitar. Grade and diploma tuba tuition are all catered for across Cambridgeshire as well as tuba tuition just for fun. Please use our service to search for tuba tutors near you and select which tuba teachers best suit your needs.
This is the only place to discover through one search the most suitable tuba teacher for your needs in Cambridgeshire, whether you want tuba lessons to learn a new instrument, develop a hobby or train as a serious musician.
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Towns: Cambridge, Chatteris, Ely, Huntingdon, March, Peterborough, St. Ives, St. Neots, Wisbech


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Marooned: Arcanus Island
Blue Machine Interactive
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Genre: Adventure
Marooned: Arcanus Island is a hardcore, survival, exploration game in which the player - or players (cooperative) - attempt to survive and eventually escape a lush tropical island. You must build a shelter to protect yourself from both the elements and the dangers that the island presents as well as tangle with everything from the wildlife to the islands natives. With beatiful graphics from Crytek's CRYENGINE, you will find yo... Read More
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You wake up washed up on a beach with nothing but your brain and your wits to keep you alive. You must gather food, water and build yourself a shelter in order to survive harsh tropical storms, tornados , hurricane's and an unknown threat that is lurking in the dark.
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Beautiful graphics and detailed characters that will require your fingers across the speed at which they are capable, fight to numbness!) As you progress through the game you'll gain new titles and new enemies will appear, each time more and more interesting. Stunning graphics and especially manifests itself in the dynamics of the game is perfect to different ages, simple operation, there is a lot of bonuses and rewards, develops coordination and reflexes.
Rating:(22) 1.78★ 35.53%
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SINCE CHEMOTHERAPY beginnings 50 years ago by Farber and his colleagues, childhood leukemia treatment has been one of the most dramatic cancer success stories.1 Currently more than 70% of children with acute lymphoblastic leukemia are alive and disease-free at 5 years, probably making it the most successfully treated of the disseminated human cancers. Certain forms of acute childhood leukemia have a 90% probability of cure, yet there is a group that is still very therapy resistant. Concurrently, in recent years, our knowledge of the molecular and cellular biology underlying these pediatric leukemias has significantly increased. We are at the point where we can reasonably answer these questions: What are the reasons for childhood leukemia treatment success compared with other cancers? Why are certain subgroups of patients therapy-resistant while most patients have very therapy-sensitive disease? I believe that our knowledge of the molecular genetic abnormalities will provide the key to understanding the treatment successes and failures in childhood leukemia.
The post World War II era witnessed the availability of chemical agents with potential value for cancer treatment. In the late 1940s, the thinking by investigators such as Sidney Farber, was that agents that antagonize important metabolites, eg, folic acid, could be useful. One such agent, aminopterin, was found to produce temporary remission in children with acute leukemia.1 By the early 1950s, an entirely different group of agents, ACTH and the glucocorticoids, became available and showed responses in childhood acute leukemia.2 It was apparent, even from these early studies with both folic acid antagonists and glucocorticoids, that childhood acute leukemias were among the most responsive of all cancers studied. Despite these responses, these early agents resulted in few cures. As the 1960s, 1970s, and 1980s progressed, other chemical agents, eg, methotrexate, L-asparginase, epipodophylotoxins, vincristine, anthracyclines, oxazaphosphorines, and more recently myeloablative therapy followed by bone marrow transplantation, have become important in childhood acute leukemia treatment success.
Acute Lymphoblastic Leukemia (ALL)
Probably the single most important advance in childhood acute leukemia treatment is the success with chemotherapy, using a combination of agents. While the late 1940s and 1950s were characterized by single agent chemotherapy development, the 1960s were characterized by the beginning of investigation into multiagent chemotherapy by several groups. These groups included the St. Jude Children's Research Hospital, led by Don Pinkel; the Children's Cancer Study Group "A" (the forerunner of the current Childrens Cancer Group); other investigators in Boston; and later the Pediatric Oncology Group and investigators elsewhere. The relatively rapid dissemination of results demonstrated the success of multiagent chemotherapy. This approach quickly became the accepted form of treatment with dramatic improvement in survival. These results are shown in Fig 1.3 Figure 1 demonstrates the change from the slow improvement of outcomes of single agent therapy in the 1950s to a second dramatic shift in the curve beginning in the mid 1960s, largely a result of combination chemotherapy. As shown in the figure, the results are most dramatic in ALL. Induction chemotherapy with vincristine, prednisone, and L-asparginase, followed by postremission therapy with mercaptopurine and methotrexate, quickly became the standard childhood ALL treatment.
There were at least two additional therapeutic advances responsible for the significant improvement in outcome during the 1970s and 1980s. One important advance was the introduction of presymptomatic therapy for central nervous system leukemia.4 A second advance was the introduction of alternative combinations and timings of chemotherapy combining multiple agents. Multiagent chemotherapy studies, while reported by several groups throughout the world, were particularly well organized by the Berlin-Frankfurt-Munster groups in Germany5 and the CCG, which demonstrated the value of delayed intensification.6 These multiagent, intensive therapy trials have continued to the present; their future probably will be tied to therapies specific for genetically defined patient subgroups.
After a dramatic improvement in the 1960s and 1970s, the survival curve for ALL began to plateau in the 1980s. Does the last point on the curve in Fig 1 indicate new advances? Time will answer this question and will determine whether the newer therapies will improve the outlook in the questionable period, ie, the 1990s and beyond.
Acute Myelocytic Leukemia (AML)
In childhood AML, combination chemotherapy also had a significant effect on outcomes, as illustrated in Fig 1, although the results have not been as dramatic as in ALL. Remission induction significantly improved with the introduction of cytarabine and anthracycline, resulting in successful remission induction in most patients.7 8 The role of postremission continuation chemotherapy in childhood AML remains uncertain, although recent evidence suggests that intensive postremission treatment with chemotherapy alone or in combination with bone marrow transplantation is often curative.9 Recently, intensive postremission therapies have been shown to result in 50% 5-year survival.10 However, as shown in the figure, there is evidence that newer therapies (and more widespread use of intensive therapies, eg, allogeneic transplantation as described in the next section) are very much needed in this group of diseases.
One of the results of the early years of combination chemotherapy was the demonstration that many leukemias quickly develop drug resistance resulting in subsequent relapse. One solution to this problem was the development of more intensive chemotherapy combined with total body irradiation followed by bone marrow transplantation. Studies in the 1970s and early 1980s demonstrated both the feasibility of this approach and the idea that some patients with therapy-resistant leukemia could be cured with combination chemoradiotherapy followed by matched sibling transplantation.11-13
In childhood AML, chemotherapy results have always been inferior to those in ALL. Thus in AML, allogeneic bone marrow was proposed as a primary form of therapy. Transplantation demonstrated that intensive postremission chemoradiotherapy followed by allogeneic marrow transplantation resulted in a significant number of patients cured of their disease.11-14 In "biologically" randomized trials, which compared allogeneic matched sibling transplantation with intensive chemotherapy in patients in first remission, disease-free survival of transplanted patients was improved over those who received chemotherapy alone.13 14 In children with AML who have a matched sibling donor, allogeneic transplantation continues to be the treatment of choice. Also, in children with AML who relapse from chemotherapy, marrow transplantation provides an opportunity for disease cure. Patients who lack a matched sibling donor are candidates for autologous transplantation. While providing cures in some patients, the role of autologous transplantation in childhood AML is less clear than for allogeneic transplants. There is evidence that autologous transplants do not provide the immunologic graft-versus-leukemia effect of allogeneic transplants15 and that reinfused autologous marrow may contain leukemia cells.16
Blood and marrow transplantation in childhood ALL has, with several exceptions, generally been confined to patients who relapse from primary therapy. Because of the excellent outcomes of most children with chemotherapy, relapsed patients have been the focus of most studies. Analysis of results from a large number of patients demonstrate that allogeneic sibling transplant gives results that are superior to chemotherapy.17 In contrast, autologous transplantation in children with ALL gave results that are, in most cases, inferior to sibling transplants but provided alternatives to chemotherapy, especially in children who relapse following primary chemotherapy.18 19 In contrast to standard risk ALL, Philadelphia-chromosome positive ALL continues to have a very poor response to chemotherapy. Allogeneic bone marrow transplant is the preferred treatment, with transplant conducted soon after induction chemotherapy.20
One of the major difficulties with marrow transplant has been the lack of matched sibling donors for most patients. Alternative donor sources of stem cells represent an exciting development in the field of blood and marrow transplant for acute leukemias. The availability of matched unrelated donors or, more recently, matched, unrelated umbilical cord donors are becoming helpful in providing additional children with transplant options. Preliminary results suggest that children with acute leukemia who receive unrelated donor marrow have outcomes that come close to those with matched sibling donors.21 Unrelated umbilical cord blood has an additional advantage over marrow in that it is readily available.22 The development of large umbilical cord blood banks will allow study of additional patients who lack HLA-matched siblings.
CML is an uncommon leukemia in children, representing less than 4% of the total of approximately 2,600 cases of childhood leukemia in the United States. Childhood CML (not to be confused with juvenile myelomonocytic leukemia) is identical to adult CML with the t(9; 22)(q34; q11) translocation and 210-kD BCR-ABL fusion gene product. The fusion gene product differs from the 185-kD BCR-ABL fusion gene product in t(9; 22)(q34; q11) Philadelphia-chromosome positive ALL (see Table 1). Transplantation is frequently curative in this disease: CML results in children are generally superior to those in adults.23
One of the undesired outcomes following successful treatment of childhood leukemia is the development of late effects; these late effects include the development of second cancers, abnormality of growth, endocrine and cardiac dysfunction, and neuropsychological defects. Second cancers have been found with significant frequency following successful chemotherapy for childhood ALL. One very large CCG study of children followed almost 5 years, demonstrated a seven-fold excess for all cancers and a 22-fold excess for central nervous system (CNS) cancer;24 CNS neoplasms were seen in children who had undergone CNS irradiation and especially in those who were 5 years old or younger at the time of treatment.24 Second neoplasms have also been observed following bone marrow transplantation. One study demonstrated a 6.7-fold increase in second cancers, primarily non-Hodgkin's lymphoma, brain tumors, and melanoma.25 Another study demonstrated an overall incidence of second neoplasms at 9.9% at 13 years posttransplantation.26
Leukemias sometimes occur following treatment with the epipodophylotoxins, which are topoisomerase II enzyme inhibitors. These leukemias are generally myeloid in type and are the result of a fusion between a portion of the MLL gene (on chromosome 11q23) and one of a variety of other partners. The therapy-related leukemias are included in Table 1. The breakpoints in MLL and the partner genes in these secondary leukemias do not differ from those seen in the primary leukemias involving these same genes.27
The past 20 years have resulted in an explosion in our knowledge of the phenotypic characteristics of leukemia. In more recent years, knowledge of the phenotype has extended to an understanding of the molecular genetic events that cause cells to become malignant.
As they became available, the application of newer laboratory analyses increased the understanding of acute leukemia biology. Morphologic evaluation over the last 50 years culminated in the widely used French-American-British (FAB) classification of childhood acute leukemia; these analyses demonstrated that approximately 80% of childhood acute leukemias group as ALL, including FAB LI-L3 types, and 20% group as AML, including FAB MO-M7 types.28 Studies in the 1970s and 1980s used antibodies to immunophenotype lymphoid leukemic blasts, which demonstrated that 85% of cases were B lineage, whereas 15% of cases of ALL were found to be of T lineage.29-31 Moreover, these B-cell lineage leukemias were found to have early B-lymphocyte development, before the maturation of surface immunoglobulin and, therefore, termed "B-precursor ALL." More recent molecular analysis of ALL has demonstrated partial or incomplete rearrangement of both immunoglobulin (B-cell) and T-cell receptor genes in these leukemias; thus, these lineage relationships suggest that ALL results in aberrant phenotypes. In parallel studies in AML, myeloid cellular phenotype identification advanced significantly with monoclonal antibody development.32 The combination of antibody-based immunophenotyping and molecular techniques allow description of a vast array of cellular phenotypes. Mixed lineage phenotypes, including T + B, T + myeloid, T + B + myeloid, or B + monocyte have been observed.
Immunophenotyping studies suggest that malignant transformation sometimes results in both aberrant and unstable cellular phenotypes. A number of studies have demonstrated these unstable phenotypes but perhaps none more dramatically than one in which leukemia cells with a mature T-lymphocyte phenotype (and irreversible T-cell DNA rearrangements) changed to mature granulocytes in the appropriate environment.33 Such unstable phenotypes are most likely the result of aberrant gene transcription, which occurs as a result of the leukemogenic process.
Many studies over the past 20 years looked at the role of cellular phenotype in predicting therapy response. The associations generally have not been strong and are clearly less predictive than other biologic characteristics, such as molecular genetic abnormalities or total body leukemia burden.
The past 10 years have been an extremely productive period in understanding the molecular genetic abnormalities in childhood acute leukemia. Rapid advances have permitted analysis of the molecular basis for the abnormalities that cause leukemia cells to differ from their normal lymphoid or myeloid progenitor counterparts. A large number of chromosomal translocations associated with distinct molecular genetic abnormalities have been described in acute leukemia (Table 1, also reviewed in references 31, 34, 42). Occasionally, these abnormalities are a consequence of mistakes in the DNA rearrangement of normal lymphoid progenitor cells in the production of functionally diverse immunoglobulin and T-cell receptor molecules. At the time of DNA rearrangement, a cellular proto-oncogene gene, eg, MYC on chromosome 8, may form a fusion gene with the immunoglobulin gene (IGH) enhancer on chromosome 14 in B-lymphoid progenitors resulting in the t(8; 14)(q23; q32.) translocation. The functional outcome of this event is dysregulation of MYC transcription (Table 1, reviewed in ref 36).
In contrast to translocations involving an antigen receptor gene, most pediatric leukemias arise from recombinations that do not involve antigen receptor genes. These rearrangements are the result of breaks and subsequent fusion between portions of the two genes. The final result is a chimeric or fusion gene protein product that in turn produces malignant transformation. These oncogenic fusion proteins most often alter normal cell function through direct dysregulation of signal transduction pathways involved in controlling cellular differentiation and proliferation or, alternatively, transcription of genes critical to these pathways (Table 1). These genetic alterations distinguish the leukemias from solid tumors, which often demonstrate mutations and deletions of "gatekeeper" or "tumor suppressor" genes as opposed to the alteration of "caretaker" or "proto-oncogenes" seen in the pediatric leukemias.
Another interesting aspect of chromosomal translocations of pediatric leukemias is the frequency with which new genes are discovered by DNA breakpoint analysis. A number of new genes that are critical for normal cellular proliferation and differentiation have been discovered through childhood leukemia analysis. Examples of new genes that were discovered through analysis of chromosomal translocations include: the BCR gene in t(9:22) ALL37; the MLL/HRX/ALL-1 gene in t(4; 11) ALL38,39; the AF4/FEL40 genes in t(4; 11) ALL; the AML 1 gene in t(8; 21) AML41; and the PML gene in t(15; 17) acute promyelocytic leukemia.42
Many cases of childhood ALL do not have detectable chromosomal translocations but instead show hyperdiploidy (with >50 chromosomes) or hypodyloidy. Up to 50% of childhood leukemias do not yet have defined molecular genetic abnormalities. As noted in Table 1, there is a remarkable number of different molecularly defined types of childhood acute leukemias, but much work needs to be done to further define the various molecular genetic events that are critical to development of these leukemias.
It is likely that chemotherapy success with ALL is partially a result of the ability of chemical agents to activate the apoptotic pathways in cells that are "poised to die." In support of the importance of active programmed cell death, there are a number of studies that demonstrate that agents which are active in the treatment of ALL (eg, corticorsteroids, epipodophylotoxins, anthracyclines) kill cells in part by activation of apoptotic pathways.43 It is tempting to speculate that this killing of cells already poised for death is a very important factor for chemotherapy success in these leukemias. As stated earlier, the most frequent forms of childhood ALL involve cells that are early lymphoid progenitors. Normal cellular counterparts are actively rearranging DNA of the immunoglobulin and T-cell receptor genes in an attempt to produce a useful antigen receptor gene. Successful rearrangement of T-cell or immunoglobulin genes requires precise joining of V-D-J segments; this process has a high propensity for failure. For successful functional antigen-receptor lymphocyte development, these cells must also escape the negative selection processes that delete self-reactive lymphocytes, and finally, these cells must be positively selected by antigen. The entire process results in a very small percentage of lymphoid progenitor cells developing into mature T or B lymphocytes. The process of programmed cell death acts very effectively in preventing the accumulation of cells that have not matured into useful antigen-recognizing T or B lymphocytes.
A second prediction from the hypothesis that ALL arises in cells that are poised to die is that the normal progenitor cells from which these leukemias arise will also be easily killed by the same chemotherapeutic agents. In fact, the lympholytic nature of corticosteroids has long been known; and other potent chemotherapeutic agents, eg, the antimetabolites, have significant effects on the lymphoid system and are often used as immunosuppressive agents.
Radiation, like chemotherapy, induces programmed cell death in both normal progenitor cells and malignant counterparts in leukemia. Radiation therapy is generally used locally, primarily with the CNS and sometimes in treatment of sanctuary sites in childhood acute leukemias.4 Systemic use of irradiation is generally in the context of stem cell replacement from bone marrow or blood. As with the chemotherapeutic agents, cell death induced by radiation is predominately due to apoptosis.
Immune system cytotoxic cells (T lymphocytes and natural killer cells) are important components of childhood acute leukemia treatment with bone marrow/stem cell transplantation (as discussed below). Apoptosis also plays an important role in the immunologic cell death using foreign "killer" cells for therapy.
One of the major challenges in the next several years is continued definition of optimal childhood acute leukemia therapy. Accumulating evidence clearly indicates that molecular genetic characterization will provide the genotypic information to make this possible. A recent group of childhood ALL experts attempted to develop uniform risk criteria based on age, white count, immunophenotype, DNA index, cytogenetics, CNS status, and early response to therapy. Unfortunately, this attempt resulted only in consensus based on age and white count.44 While these features are useful, they lack the needed degree of predictability for the individual patient. An example is the case of infant ALL in which outcomes can be predicted by molecular genetic analysis (the presence or absence of MLL gene rearrangement) much more precisely than with any other feature.45
It is clear that acute leukemia response to chemotherapy is significantly affected by the presence of certain molecular genetic abnormalities. Some examples of these specific abnormalities and their influence on outcome are included in Table 1. In childhood leukemia, the prognostic importance of molecular genetics is probably most dramatically demonstrated with the abnormalities of the MLL-AF4 and BCR-ABL type. These molecular genetic abnormalities have a profound effect on cell proliferation, maturation, and metabolism. Moreover, these abnormalities define cases that respond extremely poorly to therapy, irrespective of age and other known prognostic features. In these leukemias, it is very likely that the ineffectiveness of chemotherapy in patients with these and other abnormalities is a direct reflection of the biological characteristics of the leukemia cells. The author's bias, shared by others,46 is that the understanding of cellular genotypes will be the most factor in deciding optimal therapy, and that leukemia genotype will soon replace age, white count, immunophenotype, and other surrogate markers for leukemia cell biology.
Studies in the 1980s demonstrated that ALL patients with increased blast cell DNA content had a more favorable response to chemotherapy.47 The increased blast cell DNA is the result of hyperdiploidy (>50 chromosome per cell). Of some interest are the observations that hyperdiploid ALL blasts tend to accumulate higher levels of methotrexate polyglutamates than ALL cells that are not hyperdiploid.48 Increased sensitivity to antimetabolities and other drugs may explain the more favorable response to chemotherapy among children who have hyperdiploid ALL.49
Recently, the prognostic importance of TEL gene rearrangement as an indicator of the TEL-AML1 fusion gene (associated with a cryptic translocation involving chromosomes 12 and 21) has emerged.50 Excellent prognosis in cases with TEL rearrangement is observed with the use of antimetabolite-based therapy, known to be relatively free of long-term side effects. Of interest will be future studies to determine why TEL-AML1 leukemia is so responsive to antimetabolites. Perhaps these studies will take us, full circle, back to the early work of Farber et al 50 years ago with antimetabolites. Finally, it should be noted that TEL rearrangements are generally not seen in cases with hyperdiploidy and therefore these two prognostic indicators are independent of one another.51
In addition to studying translocation-generated fusion genes and their encoded protein products for their ability to predict outcome, they are likely to become important as specific therapy targets. We already have one example in which the fusion product is used as a therapy target: the PML-RARα (retinoic acid receptor alpha) in acute promyelocytic leukemia (see Table 1). The fusion of PML (a putative transcription factor) with the retinoic acid receptor (RARα) results in a protein that inhibits differentiation and promotes myeloid precursor cell survival.52 Leukemia treatment with high doses of all trans-retinoic acid results in cellular differentiation and remission induction with reduced morbidity, lower treatment cost, and improved long-term outcome.53 This agent acts by directly binding to the PML-RARα protein and directly converting this molecule from an inhibitor to an activator of myeloid differentiation. Interestingly, this treatment alone is not curative, suggesting that additional genetic abnormalities are likely to be important in the disease.
As information develops as to the function of some of the newly defined genes that are altered in acute leukemia (eg, AML 1, MLL, AF4, AF9, PBX), it is likely that it will be possible to use the products of these genes as therapy targets. This type of specific targeting is likely to have advantages in reduced toxicity, including the ability to reduce the use of currently toxic chemotherapeutic agents.
In the future, additional molecular targeting approaches are likely to become important. One, at the DNA level, is to use specific oligonucleotides to induce DNA triplex formations.54 At the mRNA level, specific inhibition may be indicated by antisense oligonucleotide duplex formation55 or by ribozymes.56 At the protein level, a number of targeted approaches are potentially possible: Fusion gene products are generally leukemia specific and if they are expressed on the cell surface (complexed with MHC gene products), they could be recognized by specific cytotoxic T lymphocytes.57 Competitive antagonists or decoys could be used to inhibit several types of proteins, including antigen receptors58 and activated kinases.59 Many of the newly described fusion genes result in unique protein products that bind to DNA and alter transcription of important genes. These altered fusion genes could potentially be deactivated by a variety of techniques within the cell nucleus. Inhibition of the aberrant DNA binding domains of these leukemia-specific, fusion gene transcription factors may be useful for future therapy.
Advances in childhood acute leukemia have, in the author's opinion, been dramatically aided by the willingness (even eagerness) of parents, children, physicians, nurses, and other health care workers to enroll patients on research studies that attempt to advance knowledge in the field. This degree of cooperation and collaboration among the various groups is almost unique in medical history. Children are treated on organized protocols, which, at a minimum, provide standardized treatments, and, frequently, conduct treatment studies that use randomization between one or more therapies. The cooperative spirit with which parents are willing to participate in these studies is remarkable, as most of United States children with acute leukemia are treated with one of these research protocol studies. The high compliance and cooperative spirit among all parties is remarkable and quite different from that in adult tumors. Is there a cause and effect between participation in clinical trials and better therapy outcome? These two factors could be causally unrelated but it is doubtful. In support of protocol-based treatment, there is one important study that indicates that protocol-treated patients have better outcomes than those treated off protocols using "the doctor knows what's best" therapy.60
There are probably several reasons for the superior childhood leukemia treatment results when compared with other childhood and adult tumors. The protocol-based approach discussed above is important; however, it is the author's suspicion that bone marrow's vascular nature and leukemia cell biology are the most important reasons for these excellent results. Good treatment responses are probably related to the leukemia's highly vascular nature, resulting in good chemotherapeutic agent penetration and reduction of the likelihood of hypoxia which, in turn, reduces the efficacy of chemotherapy and irradiation.61 Interestingly, the leukemia cells may induce neovascularization.62 This neovascularization may be important in the pathogenesis of the leukemias.
The excellent childhood leukemia results are, undoubtedly, at least in part due to the nature of the malignant cells. As noted earlier, childhood leukemias arise in cells that are poised to die, resulting in a high likelihood of activation of pathways of programmed cell death (apotosis) induced by chemotherapy or radiotherapy. Moreover, leukemia cells that are hyperdiploid (as is the case frequently in ALL) have increased uptake of antimetabolites. What is the role of the frequently occurring fusion genes (and their protein products) in therapy response? The answer is probably specific for the particular leukemia, as some fusion gene leukemias have a poor prognosis (eg, BCR-ABL and MLL-AF4), while others have a good prognosis, eg, those involving TEL,51 and PML-RARA.63
Prediction of the future is, of course, extremely hazardous and therefore it can only be speculated. Fifty years ago Farber et al used a folic acid antagonist as the first successful form of chemotherapy. It is of note that in these past 50 years we have learned that folic acid antagonists and other antimetabolites that inhibit DNA synthesis produce fewer secondary cancers than agents which directly interact with DNA (such as the topoisomerase II inhibitors and the anthracyclines). Incorporation of this information into planning for newer chemotherapy programs will be important.
An understanding of additional molecular genetic defects is clearly important, as the genetic defects shown in Table 1 are only a part of the story. The leukemia clone's evolution probably requires several genetic "hits" and, in late stages of the disease there are probably multiple genetic abnormalities. Examples of other additional genetic abnormalities in these leukemia cells include deletion of p53, the "cellular gatekeeper"64 or p16 INK4a, an important member of the CdK inhibitor family of genes.65 Rapid progress is underway in this field and will hopefully result in an understanding of the sequential and interdependent nature of the important molecular defects that influence tumor progression, therapy resistance, and prognosis.
Continuation of therapy improvements are likely with a better understanding of the genetic events resulting in leukemia. My expectation is that therapy will be individualized based on leukemia cell genotype. The genotype will be complex but therapy is likely to be based on the unique "leukemia genes," which are central to the early steps in pathogenesis. These very specific "leukemia genes" are of the type shown in Table 1 and should be the basis of any future leukemia classification. Genotype-specific therapies with less systemic side effects (both early and late) will be important in reducing the currently high morbidity rate and improvement of quality of life. Finally, is prevention possible? As our understanding of environmental etiologic agents develops, the situation is hopeful.
I thank Drs Jim Downing, Don Pinkel, Norma Ramsay, Steve Sallan, and Bill Woods for their willingness to assist with this commentary. However, I should be held responsible for errors of omission or commission. I also apologize for my inability, because of space limitations, to properly credit the large number of physicians, scientists, and health care workers who have contributed to the dramatic progress in understanding childhood leukemia over the last 50 years. Who would have imagined this to be possible?
J.H.K. is a recipient of an Outstanding Investigator Grant Award (CA 49721) from the National Cancer Institute.
Address reprint requests to John H. Kersey, MD, University of Minnesota, Box 806 Mayo, 420 Delaware St SE, Minneapolis, MN 55455.
- Submitted June 9, 1997.
- Accepted June 16, 1997.
- Copyright © 1997 American Society of Hematology


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Clarion Hotel , A Roberts Hotel
9027 fair forest road, spartanburg
This full service 200- room hotel offers spacious, comfortable, and flexible accommodations.
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Clarion Inn & Suites Spartanburg
50 orchard park dr., greenville
This 130-room hotel is ideal for both business and leisure guests. Clients will enjoy a myriad of marvellous amenities, including a business centre, meeting rooms and complimentary wireless Internet access. The hotel's optimum location makes it perfect for hosting a business meeting, conference, family reunion or wedding reception. Ample parking is available on the premises for added guest convenience. There are 130 rooms in total at this business hotel. A lobby, breakfast room and air conditioning also feature.
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Comfort Inn & Suites
831 congaree road, greenville
This hotel has a Business center.
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Comfort Inn Millennium
2756 laurens road, greenville
Guests can enjoy the lush South Carolina landscape on one of the many golf courses, parks and outdoor recreation areas nearby. A variety of restaurants, cocktail lounges, coffee shops and speciality stores can be found close to the hotel, with some of them being within walking distance. The air-conditioned hotel offers 117 room and facilities include a lobby, lift access, a breakfast room, conference facilities and Internet access.
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Comfort Suites
3971 GRANDVIEW DRIVE, Simpsonville
Further information about this hotel will be available shortly
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Courtyard Greenville Haywood Mall
70 orchard park drive, greenville, 29615
Located in Greenville South Carolina`s Haywood Mall shopping and dining district, this Greenville SC hotel is convenient to the Carolina First Center, Bi-Lo Center and downtown Greenville. In addition, this Greenville South Carolina hotel is located near Bob Jones, Furman, and Clemson Universities. Greenville-Spartanburg Airport (GSP) is also a quick ten minute drive from this Greenville SC hotel. Located near downtown Greenville SC, this hotel knows what is important to its guests by offering a well designed room with amenities and services for comfort and convenience that ensure the start to a successful visit to the Greenville area. This hotel near downtown Greenville SC offers a hot breakfast and complimentary high-speed Internet along with Marriott friendly service. In addition, this Greenville South Carolina hotel has earned the prestigious ENERGY STAR� label from the U.S. Environmental Protection Agency (EPA) for its efforts to conserve water and energy and protect the environment.
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Courtyard Greenville-spartanburg Airport
115 the parkway, greenville, 29615
Enjoy the Casual Elegance that is the Courtyard by Marriott Greenville Spartanburg Airport. The Courtyard by Marriott is designed for the business traveler and perfect for a leisurely getaway. From the moment you walk through the doors, you are welcomed by an inviting feel, an attentive staff, and of course, world-renowned Marriott service. You will soon realize why return guests consider The Courtyard by Marriott Greenville Spartanburg Airport their home away from home. Ease the days' stress away in the indoor pool with whirlpool, catch a workout in the modern fitness center, or simply relax in front of the fireplace of the Courtyard's airy sitting room with colleagues and friends.
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Crowne Plaza Hotel Greenville
851 congaree rd, greenville, 29607
Crowne Plaza Hotel Greenville offers 208 guestrooms. Televisions come with cable channels. Wireless Internet access is provided along with direct-dial phones, CD players, and complimentary weekday newspapers. Coffee/tea makers are provided. Bathrooms include complimentary toiletries and hair dryers. Air conditioning and clock radios are also included. A nightly turndown service and housekeeping are provided. Amenities available on request include wake-up calls. Cribs (infant beds) are also availableCrowne Plaza Hotel Greenville offers a restaurant and a bar/lounge. Crowne Plaza Hotel Greenville features an indoor pool and a fitness facility. An airport shuttle is complimentary for guests. This Greenville hotel also offers multilingual staff, gift shops/newsstands, and concierge services. Business services and secretarial services can be provided.
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Days Inn Greenville
60 roper mountain road, greenville, 29607
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Days Inn Greenville Mississippi
2701 hwy 82 east, greenville, 38701
Comfortable rooms with the modern amenities for business, family or leisure travel while providing easy access to historic, business and recreational centers.
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Econo Lodge Inn & Suites
20 interstate court, greenville
The hotel provides free airport shuttle service.
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Fairfield Inn Greenville-spartanburg Airport
48 fisherman lane, greenville, 29615
Never start a full day on an empty stomach. Enjoy the Early Eats complimentary hot breakfast, featuring the Jimmy Deane breakfast sandwich and hot freshly brewed coffee. And we'll make your business travels just a little bit easier by providing free local calls and a convenient fax service. Relax with a splash in our refreshing pool and invigorating whirlpool. At Fairfield Inn, you can always count on a friendly welcome--at an affordable price."You can expect more."
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Greenville Marriott
One parkway east, greenville, 29615
The Marriott Greenville Hotel inspires the senses with contemporary luxury, vibrant colors and southern hospitality at it's finest. Sample some tasteful items in Giatu Restaurant and Lounge or schedule a massage at MG's Grand Day spa. Finish your day in our well appointed rooms and drift off into a restful night sleep with Marriott signature bedding featuring down comforters, designer linens and fluffier pillows. The Marriott Greenville offers two ballrooms and over 10,000 square feet of flexible space to handle your meeting needs for any event, large or small. Whether you are traveling for business or pleasure, here for a meeting or social occasion, The Greenville Marriott offers superior accommodations and exceptional service.
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Hampton Inn Anderson
120 interstate blvd., anderson
historical wonders couched in southern style...welcome to the Hampton Inn Anderson.Discover a treasure trove of American history and Native American culture in Anderson, where a graceful southern style still permeates the city's atmosphere. The Hampton Inn? hotel in Anderson is located by Lake Hartwell near Clemson University, and with easy access to Belton, Honeapath, Pendleton, Williamston, and Easley.Escape to a haven of natural beauty at Lake Hartwell, where you can enjoy boating, swimming and fishing. Best of all, it is only one mile from our Anderson hotel. Explore the specialty shops and restaurants in the one of the four Anderson Historic Districts, or go back even further at the Anderson Museum and the Central Historic Museum. Get your adrenalin rush at the Anderson Motor Speedway or on the Chattooga National Wild & Scenic River. Of course, you can choose from an assortment of golf courses in this part of the country. For arts and culture, visit the Anderson Arts Center-Arts Warehouse. Ask the team at our Anderson hotel for more ideas on the local sights.services & amenitiesEven if you're in Anderson to enjoy the great outdoors, we want you to enjoy our great indoors as well. That's why we offer a full range of services and amenities at our hotel to make your stay with us exceptional.Are you planning a meeting? Wedding? Family reunion? Little League game? Let us help you with our easy booking and rooming list management tools.* Meetings & Events* Local restaurant guide
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Hampton Inn Anderson/ Alliance Business Park
411 alliance parkway, anderson
a pristine country setting at the foothills of the Appalachianswelcome to the Hampton Inn Anderson/Alliance Business Park, SC, Stay with us at the Hampton Inn? Alliance Business Park in North Anderson, SC, and you'll be in the heart of the Upstate, the birthplace of the Electric City- the very first city in the U.S. to have continuous supply of electric power, earning it this rightful title. Nestled just minutes from Downtown Anderson and the Historic District, this ALL NEW Hampton Inn affords its guests ease of access to area businesses, schools, recreational outlets, shopping and of course dining. Come see its history brought to life at Anderson County MuseumOn the shores of stunning Lake Hartwell, cradled at the foot of the majestic Blue Ridge Mountains, you'll find a pristine area of South Carolina known for its natural beauty and geographical convenience. It is here that you'll also find the Hampton Inn? Anderson/Alliance Business Park. Enjoy boating and fishing at Lake Hartwell, one of the most popular lakes in the Southeast - just six miles from our Anderson, SC hotel! In addition, Sadlers Creek State Recreation Park offers boat access to the lake, as well as campgrounds, picnicking and hiking. A half-hour drive and you'll be at the awe-inspiring Issaquena Falls, a 100-foot waterfall near Walhalla. Want to shop for deals? Anderson Jockey Lot and Farmers' Market, touted as the "South's Biggest, World's Best Flea Market," is just down the road in Belton.Our hotel is situated adjacent to the towns of Clemson, Piedmont, Pendleton, and Williamston in the heart of the manufacturing corridor of upstate South Carolina. We're 20 Minutes south of Greenville, SC home to the Greenville-Spartanburg Airport and centrally located between Atlanta, GA and Charlotte, NC along I-85. Within just a short drive of the hotel, there is so much to see and do!If education is your interest or specialty, visit one of our local colleges or universities.
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Hampton Inn Easley
8 southern center court, easley
Here at this hotel, the staff is passionate about taking good care of the customers. That's why the hotel offers a broad range of services and amenities to make guests' stay exceptional. Whether clients are planning a corporate meeting or need accommodations for a family reunion or child's sporting group, this hotel can offer easy planning and booking tools to make the process quick and organized.
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Hampton Inn Greenville
1155 vfw road, greenville, 38701
The Hampton Inn Greenville MS is the nicest hotel in Greenville. Our rooms have either a king-size bed or 2 queen size beds. All rooms have a refrigerator microwave coffee maker desk ergonomic chair hair dryer iron with ironing board lap desk and Cloud Nine Hampton Inn Bedding. Other features include complimentary wired and wireless High Speed Internet Access swimming pool state-of-the-art fitness center Business Center guest laundry and Meeting Room which accommodates up to 50 persons. We also offer complimentary On the House hot breakfast.
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Hawthorn Suites By Wyndham Greenville
48 mcprice court, greenville, 29615
The Greenville Hawthorn Suites by Wyndham is the perfect daily or extended-stay hotel in Greenville, South Carolina. This hotel is near the Carolina Expo Center, Downtown Greenville, the Bob Jones University, and the Greenville Zoo. The property was voted Greenvilles Extended-stay Hotel of the Year for 2006 by subscribers of TheLocalNewspaper.com, an affiliate of The Greenville Herald, and earned the 2007 Quality Award for Hawthorn Suites by Wyndham. Hawthorn Suites by Wyndham hotel is conveniently located just 15 minutes from the Greenville Spartanburg airport. Our hotel offers easy access to major highways, shopping, restaurants, area attractions, businesses, and downtown Greenville. We also offer the services and amenities to be your home away from home. During your stay, follow the aroma of freshly brewed coffee each morning to our complimentary, daily, hot, breakfast buffet. Experience the comfort of our spacious suites with free high-speed internet access, fully equipped kitchens, and living rooms, most featuring fireplaces. Work out in this hotels on-site fitness center, enjoy the Sports Court, or just relax in the outdoor pool and spa. And do not forget to join us Monday through Thursday in the evenings for our Managers Receptions. Enjoy all the amenities of home and experience consistency, quality and comfort when you spend your next weekend getaway or extended-stay at the Hawthorn Suites by Wyndham in Greenville. Reserve your room online today.
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Holiday Inn Express Hotel & Suites Greenville-downtown
407 north main street, greenville, 29601
Holiday Inn Express Hotel & Suites Greenville Downtown has 80 guestrooms. Televisions are equipped with premium satellite channels and pay movies. Guestrooms provide complimentary Internet access. All accommodations provide multi-line phones with voice mail; local calls are free (restrictions may apply) All units at this 2.5-star property have kitchenettes with microwaves, refrigerators, and coffee/tea makers. Bathrooms offer shower/tub combinations and hair dryers. Additional amenities include air conditioning, irons/ironing boards, and wake-up calls. Cribs (infant beds) and rollaway beds are available. Holiday Inn Express Hotel & Suites Greenville Downtown has an outdoor pool and a fitness facility. Business amenities at this 2.5-star property include a business center, small meeting rooms, and limo/town car service. Guests are served a complimentary breakfast each morning. Guest parking is complimentary. The staff can arrange business services and secretarial services. Additional amenities include gift shops/newsstands, laundry facilities, and self parking.
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Holiday Inn Express Hotel & Suites Greenville-i-85 & Woodruff Rd
1036 woodruff road, greenville, 29607
Holiday Inn Express Hotel & Suites Greenville features an outdoor pool and a fitness facility. Business amenities at this 2.5-star property consist of a business center, secretarial services, and audio-visual equipment. A complimentary breakfast is served each morning. Event facilities include conference/meeting rooms, small meeting rooms, and banquet facilities. An airport shuttle is complimentary for guests. This Greenville hotel also offers a concierge desk, multilingual staff, and complimentary newspapers in the lobby.Holiday Inn Express Hotel & Suites Greenville offers 155 guestrooms. Televisions come with satellite channels and pay movies. Wireless Internet access is provided along with multi-line phones, free local calls, and complimentary newspapers. Coffee/tea makers are provided. Bathrooms include shower/tub combinations and hair dryers. Rooms also include air conditioning. Housekeeping is provided and wake-up calls can be requested.
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Holiday Inn Express Hotel & Suites Greenville-spartanburg(duncan)
275 frontage road, duncan, 29334
Welcome to the Greenville/Spartanburg area. The Holiday Inn Express Hotel & Suites Duncan offers a great place for the business or leisure traveler, conveniently located between two chief cities. Minutes away from golf courses, restaurants, malls, theaters, the BMW plant and the GSP International Airport. We are surrounded by office parks, entertainment, historical sites and a great atmosphere. We are close to the central cites of Atlanta, Asheville, Charlotte, Columbia, and beautiful mountains. This business area is home to major companies, corporate headquarters, and training centers, such as BMW, Cryovac, Draexlmaier, Hayssen, Lear, Michelin, And the Carolina Panthers training center, and numerous others. Close by lie the colleges of our area, such as Wofford, Converse, Furman, Bob Jones, and others. The hotel houses 75 well-decorated rooms, suitable for any sort of traveler. Offering 2 deluxe suites, designed with full kitchens, separate bedroom, and sitting area, 19 one and two room suites, and suites that feature a whirlpool. Each room provides hard wire & wireless high-speed Internet access. To get your day off with a healthy start visit the fitness center, our indoor swimming pool and spa, or enjoy our Express Start complimentary breakfast offering signature Cinnamon Rolls and Smart Roast Coffee.
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Holiday Inn Greenville-i-85 @ Augusta Rd
4295 augusta road, greenville, 29605
At Holiday Inn Greenville I-85 at Augusta Road recreational amenities include an outdoor pool and a fitness facility. The hotel also features an airport shuttle and a restaurant. Holiday Inn Greenville I-85 at Augusta Road offers a restaurant and a bar/lounge. Holiday Inn Greenville I-85 at Augusta Road features an outdoor pool and a fitness facility. An airport shuttle is complimentary for guests. This Greenville hotel also offers multilingual staff, coffee in the lobby, and complimentary newspapers in the lobby. Business services and secretarial services can be provided.Rooms are furnished with sofa beds and desks. Televisions come with premium cable channels and pay movies. Wireless Internet access is provided along with free local calls and complimentary newspapers. Refrigerators, microwaves, and coffee/tea makers are provided. Bathrooms include hair dryers. Air conditioning, climate control, and clock radios are also included. Amenities available on request include wake-up calls. Cribs (infant beds) and rollaway beds are also available.
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La Quinta Inn Greenville - Woodruff Road
31 old country road, greenville
The air-conditioned city hotel has 122 rooms. Guests are welcomed in the lobby, which offers a 24-hour reception and a 24-hour check-out service, as well as a hotel safe, a cloakroom, a newspaper stand and lift access to the upper floors. Guests can dine in the breakfast room and public areas are equipped with complimentary high-speed wired and wireless Internet access. Business travellers can make use of the 24-hour business centre. The pet-friendly hotel also offers a seasonal outdoor swimming pool, laundry facilities, room and laundry services and complimentary use of a nearby gym. Complimentary parking is available on site.
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MainStay Suites Pelham Road
2671 dry pocket rd, greenville
Free shuttle service within 24 km of the hotel including complimentary airport shuttle.
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Quality Inn & Suites Spartanburg
1314 s. pleasantburg drive, spartanburg
Further information about this hotel will be available shortly
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Quality Inn Executive Center
540 n. pleasantburg dr., greenville
Walking distance to Palmetto Expo Center. Close to Bilo Center, Bob Jones University, and Greenville Tech.
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Sleep Inn Palmetto Expo Center
231 n pleasantburg drive, greenville
It is situated close to Greenville, Bi-Lo Center, Peace Center, and Bob Jones Univ.
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Staybridge Suites Greenville I-85 Woodruff Road
31 market point drive, greenville, 29607
Staybridge Suites Greenville I-85 Woodruff Road has an outdoor pool and a fitness facility. Business amenities at this 3.0-star property include a business center, small meeting rooms, and audio-visual equipment. Guests are served a complimentary breakfast each morning. Guests have complimentary access to an airport shuttle. Guest parking is complimentary. Additional amenities include multilingual staff, barbecue grills, and laundry facilities.Guestrooms have high-definition televisions with premium cable/satellite channels, DVD players, and video-game consoles. Guestrooms provide complimentary newspapers, voice mail, and multi-line phones with complimentary local calls. Beds have pillowtop mattresses. Accommodations at the 3.0-star property feature kitchens with microwaves, refrigerators, coffee/tea makers, and cookware/dishes/utensils. Bathrooms offer hair dryers. Additional amenities include air conditioning, desks, and irons/ironing boards. Housekeeping is offered. Rollaway beds are available.
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Wingate Inn Greenville Airport
33 beacon drive, greenville, 29615
This hotel features a complimentary breakfast which is served each morning. In addition to a seasonal outdoor pool, Wingate by Wyndham - Greenville-Airport provides a health club and a spa tub. Meeting facilities include conference rooms and banquet facilities. This property provides an airport shuttle, a full-service health spa, a business center, and wireless Internet access. The property has a 24-hour front desk. Onsite parking is complimentary. Guestrooms offer air conditioning and cable television. Greenville is a city of Southern hospitality, rich in history and tradition with a thriving International community. Comfort and convenience go hand in hand at the Wingate by Wyndham Greenville.
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Hilton Garden Inn Greenville
108 carolina point parkway, greenville, 29605
The Hilton Garden Inn Greenville Hotel is a brand new hotel in South Carolina committed to delivering the Ultimate Hospitality Experience. Our new hotel will not only provide you with well-appointed hotel accommodations but will make sure your stay with us is memorable and personalized to your needs. As a guest you will experience genuine southern hospitality starting with our hotel's services and amenities. Any visitor to Greenville SC will relish our hotel's complimentary services such as Complimentary airport shuttle service - /Please call hotel for pick up/ Complimentary self parking Complimentary 24-hour business center Complimentary workout facility and Stay Fit Kits Complimentary high-speed Internet access throughout hotel. Meanwhile Greenville SC business and leisure travelers alike will enjoy our other hotel features including our Outdoor salt-water pool that protects swimmers from dry skin and red eyes Relaxing Hot tub to un-wind in Pavilion Pantry sells snacks 24 hours a day Evening room-service Weekday morning USA Today Pavilion Lounge The Great American Grill our casual on-site restaurant Paved walking path and cycling path that winds through CU/ICAR. Our hotel also strives to assure our guests Sleep Deep. We provide comfortable hotel rooms that include The Garden Sleep System Bed Large work desk Two phones with voicemail speaker phone and data ports Complimentary wired and wireless high-speed Internet access 32-inch LCD TV Microwave oven Coffee maker Mini-Refrigerator Hair dryer Iron.
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أفضل الوجهات
فنادق مصر
فنادق المملكة العربية السعودية
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فنادق أبوظبي
فنادق عجمان
فنادق الخبر
فنادق أسوان
فنادق القاهرة
فنادق الدمام
فنادق دبي
فنادق جدة
فنادق الأقصر
فنادق المدينة
فنادق مكة
فنادق رأس الخيمة
فنادق الرياض
فنادق شرم الشيخ
أفضل شركات الطيران
الخطوط الجوية السعودية
طيران الشرق الاوسط
طيران الاتحاد
طيران نسما
الخطوط الجوية الفرنسية
الخطوط الملكية الاردنية
الخطوط الجوية التركية
طيران كاثي باسيفيك
الخطوط الجوية الكويتية
طيران الامارات
الخطوط الملكية المغربية
فلاي دبي
طيران ناس
مصر للطيران
طيران الخليج
الطيران العماني
الخطوط الجوية البريطانية
المصرية العالمية
الخطوط الجوية القطرية
طيران النيل
جت ايرويز
الخطوط الجوية الفلبينية
طيران بيجاسوس
طيران اونور
الخطوط الجوية السيرلانكية
طيران العربية
اير كايرو
أطلس جلوبال
طيران السعودية الخليجية


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Hisashi Kanda (神田久志 Kanda Hisashi ) is the 186th chapter of manga, Baby Steps.
Characters in Order of AppearanceEdit
For Kanda who seems to be a spoiled brat, Kabai Tech's training is a hell for him.
In team matches, a team composes of 2 singles players, 2 doubles players and a substitute player. Not only they have strong team spirit as they all live in the same dorm together, but they will also play in the All-Japan Junior.
Eiichiro then asks Araya why Kanda is in Kabai Tech while last year, he was in Yanase High. Apparently, Kanda's parents were transferred in America so Kanda decides to transfer to Kabai because they are a strong team and has a dormitory. Kanda seems to be a spoiler brat, thus adjusting to Kabai Tech's atmosphere was difficult for him at first. Kanda is forced to obey Kabai Tech's principle - work yourself to death.
Back then, Kanda does not like Kabai Tech's rule, thus he decides to quit. They only have 2-in-1 drills and he often experiences penalties, up to the point that he has not touched a ball at all. He believes that he is more skilled than most players in Kabai Tech, they should let him play the way he wants. His coach then rebukes him that a lot of alumni have managed to survive the training and become strong players. While Kanda is, indeed, has the freedom to quit, there is no reason for him to stay in the school as well since he managed to enter the school due to his tennis skills. Thus, Kanda has to reconsider his decision to quit the tennis team.
When Kanda complains his situation to his mother, he realizes that his mother already knew how difficult the training is in Kabai Tech. She lets Kanda to admit in Kabai Tech because she believes that if her son manages to overcome this challenge, he will become a stronger player. Kanda has no choice but to stay in Kabai Tech and resume the training menu. Even though he still complains on every practice, he still stands up to take the next routine - but for the coach, Kanda does not have guts, thus he has no reason to complain on their practice menu. Kanda has to work up past to his limits every single day of the training.


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Traffic People Harmony Dress, Multi-Coloured

 Retro and right on trend, this multi-coloured square patterned dress is accented with jacquard embroidery and has cropped sleeves. In a feminine Aline shape, it is a mini length has front pockets and a V cut out on the neckline. Finished with a concealed rear zip and a cotton lining. A statement choice that will look amazing with tights and ankle boots or court shoes.

Brand: Traffic People

Style Code: MT10153

Colour: Red

Sleeves: Cropped Sleeves

Length: 86cm Approx.- Mini

Material: 100% Polyester Lining - 100% Cotton

Wash Care: Machine Wash at 30°C

p-MT10153-REDTraffic People Harmony Dress, Multi-Coloured
€ 0.00 to 0.00


text:
Tempering Equipment
Paderno World Cuisine 7-7/8-Inch Long Candy Thermometer
This paderno world cuisine 5-1/2-inch syrup candy thermometer is easy-to-read Celsius candy thermometer indicates the seven stages of sugar at precise one degree intervals. The cage allows free heat passage and distances the bulb from the direct heat source.
Admetior Digital 12-Inch Candy/Deep Fry Thermometer
Digital Candy/Deep fry Thermometer has nine popular candies preset. It also has two user-set timers and makes an audible alarm once reached. The display can be detached for easy cleaning and has a pot clip for hands free use. It has an 12-inch 18/10 Stainless Steel probe.
Maverick CT-03 Digital Oil & Candy Thermomter
Digital Candy & Oil Thermometer
Admetior Digital 8-Inch Candy/Deep Fry Thermometer
Digital Candy/Deep fry Thermometer has nine popular candies preset. It also has two user-set timers and makes an audible alarm once reached. The display can be detached for easy cleaning and has a pot clip for hands free use. It has an 8-inch 18/10 Stainless Steel probe.
Taylor Connoissuer Candy-Deep Fry Thermometer
What makes the Taylor Connoissuer Line premium?This line is designed for high accuracy.Distinctive styling with easy to read dials.Full Stainless Steel construction for beauty and durability.Silicone accents for styling and ease of handling.The Connoissuer line is Taylor's best. The best thermometer you will ever use.
CDN Digital Candy Thermometer
Take the guesswork out of making candy, this innovative CDN digital candy thermometer unit is pre-programmed for precision. An instant read-out shows temperature during your candy making and an alert sounds when the temperature is ideal for hard or soft candy.
Component Design Digital Candy Thermometer, Timer and Clock
Get professional results every time! This device allows you to accurately measure the internal temperature of food while it cooks, as well as to time the cooking process. The alarms can be set independently to go off when both the desired temperature has been reached and the desired cooking time has elapsed.
Taylor 509 Connoissuer Line Candy-Deep Fry Thermometer
Our Premium Line of Thermometers represent the epitome of the Taylor Reputation.With a distinctive new look,this series clings to all things culinary. This line features full stainless steel cases designed with unique shaped oversized dials for ease of reading. The unique shape also prevents the thermometer from rolling off counter tops.The silicone accents aid in gripping and add a touch of color.This line is calibrated with pinpoint accuracy to provide quality results.Heritage,precision,quality,innovation,and style make the Connoissuer Line standout from any other-Taylor's Top -of -the- Line.
Taylor Elite 609 Candy-Deep Fry Thermometer
The newest addition to the Taylor Gourmet kitchen tools is the Elite Series. Found only in Gourmet stores for the past year -they have finally come to Amazon. The Elite Series features elegant ,sleek designs with easy to read dials. Taylor accuracy based on a 250 year tradition of accuracy in our Taylor and Salter lines .Elegant Stainless steel construction in an update of a timeless design.Tempeture readings from 100 to 600 Degree F (-40 to 230C) make this the best candy /deep fry thermometer you can imagine. The 609 comes with a pan clip for easy handling and an insulated handle for safety.
Taylor-Salter 519 Digital Candy Thermometer
Taylor-Salter 519 Digital Candy Thermometer
Taylor Classic Candy and Deep-Fry Analog Thermometer
Stainless Steel Confectionery/Deep Fry Thermometer, Pan Clip, Cool Grip Black Plastic Handle, -100 To 400&Degree F&-40 To 200&Degree, C Zoned Scale.
CIA Masters Collection Candy/Deep Fry Thermometer
Give fudge, toffee and other confections the attention they deserve during cooking. The Masters Collection Candy/Deep Fry Thermometer attaches to the pot. This keeps the probe off the bottom and away from the sides for an accurate reading of the syrup or hot oil. Temperatures are monitored in both Fahrenheit and Celsius with the large easy-read dial. To ensure the thermometer stays accurate, calibrate it with the built-in wrench and adjustment nut. Also perfect for cooking crispy deep-fried foods. Made of durable stainless steel for a lifetime of performance.
Taylor Candy-Jelley-Deep Fry Thermometer
Large Easy to Read Dial Thermometer(2.75-inch Diameter)
Maverick Heavy Duty Deep Fry/Candy Thermometer
When it comes to deep frying, or candy making, guesswork has no place. You need to know the temperature of what's in the pot. This thermometer clips to the side of the pot and is constructed from heavy duty stainless steel.
Wilton Candy Thermometer
This precision stainless steel thermometer is essential for making hard candy, nougat, fudge and more. Simply clamp to side of bowl or pan; the bulb is held securely without touching sides for precise readings.
OXO Good Grips Candy/Deep Fry Thermometer
Create sweet confections and crispy fried foods with the OXO Candy/Deep Fry Thermometer. Turn the outside indicator until it points to the desired stage of candy making or deep frying, and clip the Thermometer to your pot with the convenient easy-to-adjust pot clip. When the red dial is aligned with the indicator, your food is ready. Large, easy-to-read numbers and a storage sleeve with the stages of candy making and deep frying.
Polder THM-515 Candy/Jelly/Deep Fry Thermometer, Stainless Steel
Polder has been offering everyday products with extraordinary design since its launch. The company was established in 1976, delivering better quality European-styled housewares to the U.S. market. Throughout the years, Polder has built an eclectic collection of core home categories, including kitchen timers and thermometers, laundry and ironing products, kitchen scales, and a variety of other storage solutions. Polder products are tested and certified for their consistent high quality by independent standards labs. This thermometer is a perfect example of the high standard product.
CDN TCG400 Professional Candy & Deep Fry Thermometer
Item #: 14-0359. Instrument Range: 100 to 400 F/40 to 200 C 8"/20.3 cm color-coded scale Waterproof Target range indication 2-way mounting: hang/stainless steel clip Customers also search for: Restaurant Supplies\Kitchen Supplies\Thermometers, Scales and Measures\Thermometers restaurant equipment, kitchen supplies Discount Candy/Deep Fry Ruler Thermometer, Buy Candy/Deep Fry Ruler Thermometer, Wholesale Candy/Deep Fry Ruler Thermometer, TCG400, Thermometers


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Future First Lady (sort of – potentially) Ivanka Trump was harassed aboard a flight this morning by a radical leftist who is upset that her father is the next president of the United States.
Some people just don't want their taxes to shrink and America to thrive, I guess.
It's still Obama's America.
FYI, Ivanka and family were flying coach.
From TMZ:
Ivanka was on a JetBlue flight leaving JFK Thursday morning with her family when a passenger started screaming, "Your father is ruining the country." The guy went on, "Why is she on our flight. She should be flying private." The guy had his kid in his arms as he went on the tirade.
A passenger on the flight tells TMZ Ivanka ignored the guy and tried distracting her kids with crayons.
More from Twitchy (including now deleted tweets):
So, the guy admits his "husband" was harassing Ivanka but can't understand why people are making a big deal about it OR why they were booted from the flight?
Liberal logic, for ya.
Don't liberals understand that Ivanka is more liberal than she is conservative?
It won't be easy being a Trump for the next four to eight (or even 20) years.


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Supreme Court Blogs
Latest judgement from Supreme Court and High courts of India.
Owner: shekhawat
Listed in: Law
Other Tags: Latest, Judgement, Decesion, High Court
Justice Juice - Your daily glass for original criminal justice, forensic science, IT security, and.. internet security news and articles.
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Listed in: Law
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JotForm is a free online form builder which helps you create online forms without writing a single line of code. No sign-up required.
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Alert email on usageAsked by ICA_Forms on June 12, 2014 at 01:41 PM
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All these pictures are from the monumental grave chamber of Eyüp, which is covered with Iznik tiles of the best quality. The grave proper is in a room that one can look into through elaborate grating. In the room where the believers gather there is a showcase with what must be a footprint of the prophet, I distinctly think it used to be in the Topkapı museum. Here it is much more in its proper place.On the picture: A calligraphic panel; inlay of mother-of-pearl in tortoise-shell.Marquetry, with inlays of ivory, tortoise-shell and mother-of-pearl became one of the major decorative arts in Ottoman times. Because of its luminous and multicolored reflection, mother-of-pearl was particularly popular, in spite of its hardness and brittle nature, which made its treatment complicated.Islamic calligraphy, also known as 'Arabic calligraphy', is the artistic practice of handwriting, calligraphy, and by extension, of bookmaking, in the lands sharing a common Islamic cultural heritage. This art form is based on the Arabic script, which for a long time was used by all Muslims in their respective languages. Ottoman Turkish calligraphy is associated with abstract arabesque motifs on the walls and ceilings of mosques as well as on the page or panels. The calligrapher can pursue different goals: the pure beauty of the line, the readability of the text, the monumentality of the inscription, symmetry, dynamic flow, even the suggestion or contours of an object.Muslims used calligraphy to represent God because they denied representing God with images. It is especially revered among Islamic arts since it was the primary means for the preservation of the Koran. Suspicion of figurative art as idolatrous led to calligraphy and abstract depictions becoming a major form of artistic expression in Islamic cultures, especially and particularly in religious contexts.Correspondent: J.M.Criel, Antwerpen.Source: (amongst others) Wikipedia.
For any use: see my Profile. NOTE: Many of my pictures are in sub-galleries (some within another, their name is in bold print)!


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This rectangular rug features Machine-made weave type that helps make the textile an inviting addition to any indoor space. Geometric patterned area rug will be the perfect accessory to add that finishing touch to your decor. Whether you're looking for a splash of color or a subtle accent, this solidly colored area rug is a wonderful choice.
- Topaz collection
- Brand: Kalora Interiors Inc.
- Made of 100% Polypropylene
- Machine-made
- Multicolor finish
- Shape: Rectangle
- Geometric pattern
Dimensions:2'0" x 3'7"
Kalora is the biggest manufacturer providing rugs to accentuate great furniture. It develops successfully since 1984. Over the years, Kalora has had the opportunity to expand its selection of products and sources of supply, including machine-made rugs from Belgium and Turkey, as well as handmade rugs from India. Kalora boasts wide collections variety, original design, exceptional quality materials and acceptable prices.
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From contemporary and minimalist to bizarre, our modern rugs and carpets give your home a great softness, warmth and burst of color. With an extensive selection of different colors, styles and patterns, they blend in nicely with your home decor. The braided or shag rugs are made from wool, viscose and cowhide and have deep and rich colors which will create intensive and bold statement in your rooms.


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Welcome to Firefox for Android Add-ons.
Add extra features and styles to make Firefox for Android your own.Close
Review for Sparks Fly by SaSSyGirL
Rated 5 out of 5 stars
Your designs are exceptional! The fact that you take your own pictures makes each of your designs that much more special! Kudos to you Brian! =)
To create your own collections, you must have a Mozilla Add-ons account.


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I have a friend who's dating an Asian guy, and they look so awkward. I mean the guy is 3 years older than her, but he looks 5 years younger. It just seems out of place. Does anyone else notice this?
Most Helpful Guy
i don't think they look so awkward. but its your mentality looks so awkward10|10|0
Most Helpful Girl
The same as I'm dating a guy who I'm 3 years older than but it looks like he's dating a 12 year old. Because some people just age slowly10|10|0


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Game Room Décor Image Acoustic Panels
Finding the right game room décor without challenging your existing design can be difficult, but it's not impossible. Audimute offers a variety of standard and custom game room décor options that are guaranteed to look great in your space! Audimute's Standard and Custom Image Acoustic Panels combine aesthetics with function bringing high quality imagery together with top of the line acoustic performance.
Browse through our collection of Game Room Décor Acoustic Panels to find the right décor for your game room. If you can't find what you're looking for you can upload your own high resolution artwork or photographs to be printed on acoustic fabric.
Audimute's Acoustic Panels for Functional Game Room Décor:
Don't stop at just your game room décor! Audimute's Acoustic Panels fit in any room of your house. With several standard image galleries and the option to upload your own artwork you can easily find the right décor for any space! Give one of our acoustic specialists a call today at (866) 505-6883 to discuss adding acoustic panels into your game room décor.


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Yandle lifts Coyotes past FlyersNov 22, 2009 - 4:05 AM
Yandle scored a power-play goal with 9:41 remaining to help the Coyotes beat the Flyers 3-1 on Saturday night for their second victory in three games.
"I just found a lane and Lombo (Matthew Lombardi), he's a great passer," Yandle said. "He found me and I shot it where I wanted it. It's usually not like that."
Lombardi had a power-play goal and an assist, and Shane Doan added an empty-net goal without putting the puck in the net for the Coyotes.
Scott Hartnell scored for the Flyers, who have lost two straight after winning seven of their previous eight.
Yandle's goal came moments after Adrian Aucoin bobbled a bouncing puck on the blue line. As coach John Stevens and the Flyers bench screamed for an offside call, Aucoin moved the puck to Lombardi, who passed to Yandle at the top of the left circle. Yandle took one stride in and beat Ray Emery with a hard wrist shot past his outstretched glove.
"I guess the other guys, the other team, thought it maybe was an offside," Lombardi said. "Yands just foiund a hole there and I kind of threw it to him and he made a great shot."
After the game, Stevens and Flyers players said one linesman was raising his arm to call offsides while the other waved off the violation.
"We all thought it was offsides and the players reacted to it," Stevens said. "But we still have to kill off the power play."
Added Hartnett, "You can't blame Ray for that one. He thought what we all did."
Doan was credited with a goal with 39.9 seconds after he was hooked by Chris Pronger while attempting to shoot on the empty net after Emery was pulled for an extra attacker.
"He (the referee) said I got him on the hands but I got him on the stick," Pronger said. "I disagree. I didn't think it should have been a goal. I didn't even think it was a penalty. He had his stick down. How am I going to get him on the hands when I lifted his stick?"
After a scoreless first period, Lombardi briefly gave Phoenix the lead. Doan drove the puck into the low slot, tapped a back pass to Robert Lang in the right circle and Lang found Lombardi in the middle of the left circle for the one-timer past Emery at 4:49 of the second period.
"We've been looking for a couple of plays that matter and those were the plays," Coyotes coach Dave Tippett said.
The Flyers answered quickly, with Hartnell taking a long outlet pass from Claude Giroux while skating backward into the Phoenix zone before turning and firing the puck over Ilya Bryzgalov's glove and just inside the right post.
NOTES: Doan tied Thomas Steen for third place on the franchise goal list with 264. ... Lombardi's goal was his first since October 22. He missed the past three games with an upper-body injury. ... The Coyotes were perfect on five penalty kills and have successfully killed 11 straight penalties over three games. ... Philadelphia has not won in Phoenix since 2003 and is 1-5-0 on the road against the Coyotes dating to 2000-01. ... Flyers center Blair Betts returned to the locker room late in the first period with a dislocated right shoulder and will miss at least a month. ... Phoenix defenseman Ed Jovanovski was scratched for the seventh straight game because of a lower-body injury. ... Emery has started 18 of 20 games this season and 10 of the Flyers' past 11.
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rootsMattDOOM777 Added 5 roots
Flyers 1, Coyotes 3 FinalNov 22 1:47 AM
- -------------------------------------------
0 1 0 --1
Phoenix 0 1 2 --3
FIRST PERIOD -- Scoring: None. Penalties: O Bartulis, Phi (delay of
game), 8:42; J Vandermeer, Pho (holding), 12:09.
SECOND PERIOD -- Scoring: 1, Phoenix, Matthew Lombardi 4 (power play)
(Shane Doan, Robert Lang), 04:49. 2, Philadelphi
Nov 21 10:26 PM
Flyers 1, Coyotes 3 3rd - 0:40Nov 21 10:24 PM
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rootsRUWTbot Added 15 roots (Close Finish)
Flyers 1, Coyotes 2 3rd - 3:30Nov 21 10:18 PM
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rootsRUWTbot Added 12 roots (Close Finish)
Flyers 1, Coyotes 2 3rd - 6:40Nov 21 10:10 PM
Flyers 1, Coyotes 2 3rd - 9:42Nov 21 10:07 PM
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rootsRUWTbot Added 11 roots (Close Finish)
Flyers 1, Coyotes 1 3rd - 10:50Nov 21 10:05 PM
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rootsRUWTbot Added 22 roots (Close Finish)
Flyers 1, Coyotes 1 3rd - 12:20Nov 21 10:02 PM
- --------------------------------------
0 1 --1
Phoenix 0 1 --1
FIRST PERIOD -- Scoring: None. Penalties: O Bartulis, Phi (delay of
game), 8:42; J Vandermeer, Pho (holding), 12:09.
SECOND PERIOD -- Scoring: 1, Phoenix, Matthew Lombardi 4 (power play)
(Shane Doan, Robert Lang), 04:49. 2, Philadelphia, Scott Hartnell 7
Nov 21 9:32 PM
Flyers 1, Coyotes 1 2nd - 12:46Nov 21 9:10 PM
Flyers 0, Coyotes 1 2nd - 15:11Nov 21 9:04 PM
- ---------------------------------
0 --0
Phoenix 0 --0
FIRST PERIOD -- Scoring: None. Penalties: O Bartulis, Phi (delay of
game), 8:42; J Vandermeer, Pho (holding), 12:09.
Shots on goal:
Philadelphia 6 --6
Phoenix 5 --5
Goalies :
Nov 21 8:40 PM
Related News
- Coyotes D Chychrun undergoes knee surgery Aug 3
- NHL Note - Arizona Coyotes Chychrun, Jakob Aug 3
- Coyotes add MacLean, Allen to coaching staff Jul 26
- Coyotes, Tucson make it official: Moving AHL team to city May 19
- Tucson city council approves deal for Coyotes AHL affiliate May 17
- AHL board approves sale, relocation of Coyotes' affililate May 10
- 'The Goldbergs' creator talks love affair with Flyers May 10
- Arizona's Chayka becomes youngest GM in NHL history May 5
- AP Source: Coyotes to promote 26-year-old Chayka to GM May 4
- McDavid among finalists for Calder Trophy as NHL top rookie May 2
- Flyers F Schenn suspended for 3 games for charging Apr 26
- Capitals' Orpik could be difference-maker vs. Penguins Apr 26


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With a third of the NBA season in front of them, the Raptors have regrouped, imbued with a sense of optimism, aided by an injection of experience and athleticism, bound and determined to put the memories of a desultory 55 games behind them.
It is a large hill to climb – five games in arrears of the playoffs with 27 games to go – but to see and hear them yesterday was to hear a confident group, even if the past suggests little reason for such unbridled enthusiasm.
The arrival of Shawn Marion, and to a lesser extent Marcus Banks, has created a buzz around a team that's been listless too often this season.
"Now that we have new teammates, it's kind of a better chance to start fresh," Chris Bosh said yesterday. "There's a little bit of excitement now. ... It helps the team out and we have a chance to redeem the first half because if we make the playoffs, everybody forgets about it."
Making the playoffs, or even making a run at them, will depend largely on how well Marion fits in with his new team and how quickly. The 6-foot-7 Marion, equally adept at playing either forward position, will be in the starting lineup tonight when the Raptors meet the Cleveland Cavaliers and he's not at all concerned about fitting in to any intricate sets.
"We're going to try and make it happen," Marion said. "I'm one of those players who you can just throw in with anybody and I can find a way to gel and find a way to make us good."
Marion's strengths are his ability to play multiple positions and the athletic ability he brings. He's averaging 8.7 rebounds per game this season – which makes him Toronto's second-best rebounder – and is known as someone who can get points in myriad ways. He's an okay jump shooter who doesn't have three-point range, but somehow manages to average nearly 13 points per game.
"He's got the athletic ability to create, he's a very good passer, finds open guys and just has a real quickness to the basketball," said Toronto coach Jay Triano. "If something does break down, he can flash and get inside or put the ball on the floor and drive if he has to.
"He creates turnovers, rebounds the basketball and those are the two things that lead to transition basketball."
And transition basketball is now a motherhood issue with the Raptors, who vow to play quicker with a better athlete in the mix.
His experience in Miami, where the delightful Dwyane Wade dominated the ball in a halfcourt offence, was in stark contrast to Marion's time with Phoenix at the heyday of the run-and-gun Suns. Toronto seems to be somewhere in between, which suits Marion just fine.
"A lot of teams can (run) in the league, they just don't do it; they want to sit there and pound the ball," he said. "The game is supposed to be exciting. I'm tired of playing that boring style, halfcourt, just watching everybody go up and run a play, call this play, run this play. That's boring, I'm not going to lie to you. And I know fans don't enjoy it, either. It's cool when you get a couple of highlights here and there, but people like to see teams have high-scoring games and dunks and stuff, that's what it's all about."
While he will likely be the nominal small forward, and gets the unenviable task of guarding LeBron James tonight, the 30-year-old doesn't want to be pigeon-holed.
"When you look at me, I want you to look at me as a basketball player," he said. "Don't label me at a position. I'm able to guard one through five, easily."


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Getting firsthand information from an actual car owner is one sure way to get an idea of car performance once it leaves the lot. Autobytel features real consumer reviews that give the unbiased experience of a car.
Good Overall
Pros: price
Cons: TiresCompetent all the way around.
Another Hit by Hyundai
Pros: The Interior
Cons: Back Seat Head RoomHyundai has pulled another hit from the factory. The totally redesigned Elantra is an eye catching vehicle worthy of consideration over the Corolla, Cruze and Mazda3. The interior quality is top notch in the Limited model. I'm 6'1' and the driver seat is very comfortable and with my seat set, I can get into the back seat with no problems. The only concern is that if I'm sitting in the back, my head does hit the back roof line, but there is enough room for me to slouch into a comfortable position. And that is the only gripe I have about this car. I've had it for 2 weeks and have put 2,000 miles on it and I'm averaging 36mpg mostly highway miles. The ride is smooth enough, the engine has ample power and just quiet enough. I purchased this car fully loaded and the navigation is great and the sound system more than powerful enough. It has an easy iPod/iPhone interface as well as USB connection. There is even an power outlet next to the passenger so they can charge their gadgets as well. I've not seen the new 2012 Focus other than on-line and the same for the 2011 Civic, but from what I've seen the Elantra will hold it's own. It even has heated back seats. I'm very impressed by this car and I would tell everyone who needs a good looking car that gets great gas mileage to include the Elantra in their search.
Car Reviews
Pros: The engine and transmission
Cons: The dark blue readouts are difficult to see in daylight.I just purchased the 2011 2.0T coupe with 6 speed manual transmission about a week and a half ago. It handles extremely well, whether around curves or up steep hills (especially in 3rd.) This vehicle is the most enjoyable one that I have ever owned in 50 years of driving. We are going up the coast to Cambria, CA this weekend to give it a real shakedown cruise on the freeway and Route 1.
I love this car!!
Pros: Comfortable ride and reliability.
Cons: After seven years the paint on the outside door handles peeled.This is my third Sonata and I love each one more than the last. My next car will be a Sonata, nothing else will do.
2011 Sonata - What a value!
Pros: Engine is outstanding, power with mpg in spades
Cons: Front seats need power adjustment and memory for driver.Does it all well. Handles very well, smooth riding and tons of room. It runs quiet and so quick you wouldn't think its a 4 cyl. Gas mileage is outstanding, almost like a hybrid on the highway. Wish the front seats were a little more comfortable (softer/wider), and included memory. The passenger front seat is too low, needs power there also. People in back love the heated rear seats. I'd buy again.
gas saver
Pros: high gas mileage
Cons: nothingits good on gas and get me from a to b
2011 GLS 4 cyl
Pros: MPG
Cons: road noiseThis is my second Hyundai and I love it. Great value and quality. The 4 cyl has plenty of excelleration and for towing small trailers or ones with built in breaks. Plenty of room for my kids. We love it. Road noise is a little more then some, but for the price, you can't beat it.


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oh you mad cuz i'm stylin on you
Posted on November 26, 2015 at 17:24
After a few hours of trying to come up with a new, minimalistic low-res style, I came up with this:
The knees still need some tweaking but aside from that I think I have a good foundation to start making more complex animations with.
Gonna see how much spritework I can get done over the holiday weekend so stay tuned!
Dev - Er, any ideas how to make this work?
Related Posts
I'm not really interested in making a fighting game as I would be making some sort of platformer action RPG. After playing Undertale I've been motivated to look into reviving my old JTMK project as an action RPG instead of the original Gunstar Heroes-like run and gun idea I had for it.
Anyways I went ahead and quickly added a few in between frames with Aseprite. It's still very rough around the edges but I can easily smooth it out
Also working on a running animation. It's not as stylized as I'd want to be so I might end up scrapping it: