text:
1The band who trolled RNC concertgoers
The band was expected to cover several pro-America anthems—and play their hits, of course—for the RNC-friendly audience in attendance, but that's not how things went down. Instead, frontman Stephan Jenkins frustrated the crowd over and over again by expressing his displeasure with their conservative views. He showed support for things like gay rights and science (both of which received boos) and then played nothing the crowd recognized. Jenkins didn't seem to care. "You can boo all you want, but I'm the motherf****** artist up here," he proclaimed.
Later, the band responded to fans who expressed their displeasure on social media through its official Facebook account: (Source)
2The convention speaker who claimed Hillary Clinton was influenced by Lucifer
When later asked to explain the Clinton/Prince of Darkness connection, Carson pointed out that Clinton considered community organizer Saul Alinsky her mentor, and had referred to his famous book Rules for Radicals in her college thesis. Alinsky, meanwhile, had once appeared to praise the devil. "On the dedication page, he acknowledged Lucifer in an admirable way, saying that he's the original radical who gained his own kingdom," Carson explained. "Please read the book, because it's very interesting how it uses controlled anarchy to change us from a democratic republic to a socialist society."
Baffled newsman Chris Cuomo brought up Carson's history of excusing his own previous behavior—such as trying to stab a friend when he was a young man—and asked why he was so quick to forgive his own past while hammering Clinton's undergraduate Alinsky connection. "It was something that was personally important to her in 1969. I think there's no question about that," he elaborated. "It's just what you choose to use as criticism, especially as somebody who has said many times, 'don't judge me by something that long ago, judge me by right now. ' If she believed that at that time—and now you look at her actions—you look at what she advocates, the killing of babies, the dissolution of the traditional family, all these kinds of things—those are pretty consistent, quite frankly." (Source)
3Male escorts made mad money from RNC attendees
The Post interviewed several escorts who claimed they were raking it in. One said he had already earned $1,600 since the convention started—over six times the amount he usually makes in any given week. Another claimed he made about $800 per day since the convention kicked off (he typically charges $250 an hour)—all from men visiting from Florida, Louisiana, and Washington, DC. (The clientele included mostly married white men between the ages of 40 and 50, said a third escort.)
Unfortunately, females didn't fare as well—those who were interviewed by the Post said business for them was slower than usual. (Source)
4An unusual selection by the RNC house band
The album that "Station to Station" comes from—also titled Station to Station—was recorded by Bowie while he was using heavily, and the late musician claimed not to remember any of the creative processes behind it.
The song comes from Bowie's "Thin White Duke" phase, during which time he bore a controversial fascination with fascism and, particularly, Nazi symbolism. Could Smith, who is not a Republican, have been implying something in his musical choice?
(Source | Photo)
5The anti-Trump movement that died at the RNC
Trump opponents of wanted to free up delegates to support another candidate. The Republican Party was having none of it, however, and shut down the protest vote with authority.
Chaos on the floor quickly streamed to social media where "Never Trump" supporters could be heard chanting "roll-call vote" over and over. But in the end, the group lost their bid for such a vote, eliminating their chances of a coup and forcing delegates to vote along their state's primary results. That's because the convention chairman claimed that three of the nine states withdrew their request for a roll call, and the movement lost the minimum number of states it needed to try and force a formal vote. (Source)
6The writer who took responsibility for the controversy surrounding Melania Trump's speech
Meredith McIver, an in-house staff writer for the Trump Organization, released a statement saying she wrote down portions of the Obama speech—with Mrs. Trump reading them to her over the phone—and included them later in the draft. She apologized, saying, "I did not check Mrs. Obama's speeches. This was my mistake, and I feel terrible for the chaos I have caused Melania and the Trumps, as well as Mrs. Obama. No harm was meant."
McIver offered to quit, but the Trump family refused to accept her resignation. "Mr. Trump told me that people make innocent mistakes and that we learn and grow from these experiences," she said. "I asked to put out this statement because I did not like seeing the way this was distracting from Mr. Trump's historic campaign for president and Melania's beautiful message and presentation," McIver concluded. (Source | Photo)
7The laundry list of musicians who are upset that their music was used at the RNC
James Grimmelmann, a copyright scholar at Cornell University, believes the GOP probably did need to acquire a license before using any music, but it wouldn't have to do so from the artists in question. The necessary permissions are available from a performing rights organization called Broadcast Music Inc. Securing rights from organizations like BMI is a standard step in organizing any big campaign event where music is going to be played. The question remains as to whether or not the Trump campaign actually did so.
BMI operates under close antitrust scrutiny; it's required to license its music to all comers on a nondiscriminatory basis. In other words, a band doesn't have the option of licensing its music to BMI with a "no Donald Trump" or "no Republicans" restriction.
The vast majority of the time, musicians' complaints about politicians using their music don't go anywhere. The goal of the complaint is more to send a political signal to their fans than it is to stop the use of their music, and what exactly happened at the RNC remains to be seen. (Source | Photo)
8The former presidential candidate who refused to endorse Trump and suggested Republicans "vote their conscience"
The result was a moment of high drama in the convention hall, as delegates booed Cruz angrily and waved their arms. Some even rushed the stage. The next morning, Cruz was met with anger and denunciations from many sides and was even heckled at a breakfast meeting of his own Texas delegation, where a vocal minority of the crowd was furious.
Cruz remained defiant, and it made it clear he was not about to endorse Trump, after a brutal primary campaign where the candidate dismissed him as "Lyin' Ted," mocked his wife's looks, and linked his father to the assassination of President John F. Kennedy. (Source | Photo)
9The sexist, misogynist anti-Hilary swag sold outside the RNC
10The delegates that were sickened by the highly contagious norovirus
The infected team members, staying an hour outside of Cleveland, were put under quarantine. A state party leader warned delegates to stay off the buses that shuttle them to the Quicken Loans Arena if were experiencing any of the symptoms mentioned above.
Health officials said those affected by the virus were plagued with symptoms which included vomiting and diarrhea. (Source)


text:
In North Texas, a mega-church preacher was beaten to death with a guitar by an attacker who ran his car through the church wall. The preacher was rumored to have been playing the Amazing Grace version by Justin Bieber on his six string just before the attack. God has forgiven the killer.
Now AWD admits, there's nothing like bad guitar picking to put me in the mood to drive my F-150 through a wall and bash somebody upside the melon with my bad-ass Stratocaster! Hell, even the god-awful, bad music those young little bastids listen to these days makes me want to wrap my acoustic around somebody's noggin! But AWD is a civilized cat who finds beauty in everything. Even sh*tty crap that young'uns listen to today.
Here's what I'm talking about. Listen to this from the young lady Bieber:
I hope Steely Dan is chasing the dragon with the water turning to cherry wine so they don't ever hear that garbage! All I can say is Bieber better stay out of swinging range of my Stratocaster-o-death!
Now, compare the above garbage to this art:
"Learn to work the saxophone, I play just what I feel. Drink Scotch whiskey all night long, and die behind the wheel. They got a name for the winners in the world, I want a name when I lose. They call Alabama the Crimson Tide, call me Deacon Blues."
I rest my case. Score one for America!
Open Post time. Drudge is saying there's a sex scandal coming out on a big US Senator. I know I'm not a religious man and I've pretty much chapped the rear end of the big man upstairs a time or two, but please Lord let it be Douche Bag Harry Reid!! Or Chuck Schumer. Or Lurch Kerry….probably getting it on with some hot mares in the stable. Of course, a sex scandal is a badge of honor to a Dim.
You can post your very own prediction about the upcoming election, too. Or try to guess the poundage of NJ Governor Chris Fat Bastid RINO Christie. Or you can say snarky things about Hopenchange. Or basically, you can do what you want. You're on your own.
For Music That Doesn't Suck tonight, what else could it be but Frank Zappa's "My Guitar Wants To Kill Yer Mama?" Well, this version by a few hot guitar slingers is pretty damn good. I like it better than the original. Actually, I like both. But I've always been a sucker for love songs. Here you go!
And for all you goat ropers with anger management problems, you might want to leave your guitar at home on Sundays!

subset: commoncrawl


text:
|Publication number
|Publication type
|Application number
|Publication date
|Aug 4, 2009
|Filing date
|May 3, 2006
|Priority date
|May 6, 2005
|Fee status
|Also published as
|Publication number
|Eugene N. Scarberry, Michael B. Jaffe, Peter Chi Fai Ho
|Original Assignee
|Ric Investments, Llc
|Export Citation
|BiBTeX, EndNote, RefMan
|Patent Citations (24), Referenced by (10), Classifications (23), Legal Events (3)
|External Links: USPTO, USPTO Assignment, Espacenet
This application claims priority under 35 U.S.C. � 119(e) from provisional U.S. patent application No. 60/678,263 filed May 6, 2005, the contents of which are incorporated herein by reference.
1. Field of the Invention
The present invention relates to a respiration monitoring apparatus, and, more particularly, to a mask with a respiratory gas measurement site that obviates the need for the operator to separately assemble a respiratory gas measurement component to a mask and minimizes dead space and breathing circuit resistance.
2. Description of the Related Art
A variety of respiratory masks are known that have flexible seals and cover the nose, mouth, or both of a human patient. The mask seal, which is also commonly referred to as the cushion, creates a seal against the patient's face. Because of the sealing effect that is created, gases can be provided at a positive pressure within the mask for delivery to the airway of the patient.
The uses for such masks range from high altitude breathing, i.e., aviation applications, to mining and fire fighting applications, to various medical diagnostic and therapeutic applications. For example, such masks are used in the delivery of non-invasive positive pressure ventilation (NPPV) and the delivery of anesthesia. NPPV may be delivered as a continuous positive airway pressure (CPAP) or variable airway pressure, such as a bi-level pressure that varies with the patient's respiratory cycle or an auto-titrating pressure that varies with the monitored condition of the patient. Typical pressure support therapies are provided to treat a medical disorder, such as sleep apnea syndrome, in particular, obstructive sleep apnea (OSA), or congestive heart failure. NPPV also includes delivering life-supporting ventilation or ventilation that augments the patient's own respiratory effort.
Examples of conventional respiratory masks used in the medical field for providing a positive airway pressure to an airway of a patient are described in U.S. Pat. No. 5,243,971 to Sullivan et al., which teaches a bubble-type of patient interface in which the seal is attached to a shell and extends from the shell in a concave fashion. Other conventional masks are disclosed, for example, in U.S. Pat. No. 5,540,223 to Starr et al. and U.S. Pat. No. 6,467,483 to Kopacko et al.
A still further type of mask is described in U.S. Pat. No. 5,647,357 to Barnett et al. and U.S. Pat. No. 6,397,847 to Scarberry et al., which uses a gel material as the seal or cushion to maximize patient comfort and sealing properties. U.S. Pat. No. 4,971,051 to Toffolon teaches a mask in which the seal includes multiple flaps, again to optimize patient comfort and the sealing property.
The need to effectively titrate therapies, such as NPPV, based on clinical measures, such as the patient's arterial levels of carbon dioxide (PaCO2) and/or changes in those levels, are being increasingly recognized. Recent studies have shown that in patients with dead space to tidal volume ratios less than 0.65, PaCO2 and PetCO2 are highly correlated. Additionally, it has been shown that changes in end-tidal carbon dioxide levels correlate well with changes in PaCO2. It is changes in these levels that can be used to assess the effectiveness of changes in therapy.
The end-tidal carbon dioxide levels are determined from the patient's expiratory carbon dioxide gas. The patient's expiratory carbon dioxide gas is measured by gas analyzers that are typically categorized into two different types: (1) "non-diverting" or "mainstream" gas sampling systems; and (2) "diverting" or "sidestream" gas sampling systems. A mainstream gas sampling system includes a sample cell that is disposed along the main path of a breathing circuit through which a patient's respiratory gases flow. As a result, all of the patient's inspired and expired respiratory gases pass through the sample cell, which is also known as a "cuvette". A gas sensing system, which includes the elements necessary for monitoring respiratory gases, is coupled to the sample cell to measure the constituents of gas passing through the sample cell. For infrared gas sensing, the gas sensing system includes a radiation source and detector. An example of such a conventional mainstream gas measurement system using infrared gas sensing is described in U.S. Pat. No. 4,914,720 to Knodle et al.
A sidestream gas sampling system transports a portion of sampled gases from the sampling site, which is typically a breathing circuit coupled to the patient's airway or directly at the patient's airway, through a sampling tube to the sample cell, where the constituents of the gas are measured by a gas sensing system. Gases are continuously aspirated from the sample site through the sampling tube and into the sample cell, which is located within a gas measurement instrument. Examples of conventional sidestream gas sampling systems are taught in U.S. Pat. No. 4,692,621 to Passaro et al.; U.S. Pat. No. 4,177,381 to McClatchie; U.S. Pat. No. 5,282,473 to Braig et al.; and U.S. Pat. No. 5,932,877 also issued to Braig et al.
The increasing sophistication of therapies, such as NPPV and the currently available gas monitoring technologies, make the combination of these two modalities attractive and potentially clinically beneficial for the management of patients suffering from respiratory failure. Their actual use in clinical practice is limited due to a number of factors that are methodological, technical, and educational in nature. Methodological problems relate to the selection of the proper patient interface, management of leaks around the mask seals, which complicates the interpretation of the measurement as well as adding to inconvenience and the added complexity of the gas measuring apparatus. Technical problems of combining gas measurement technologies and masks relate to the added deadspace of the additional breathing circuit components, such as the airway adapter portion and its associated rebreathing, the added pressure drop of the additional breathing circuit component and its affect on the therapy being delivered, and the need to provide for the possible use of either sidestream or mainstream gas sampling technologies. For example, the choice of a nasal, full face, or a mask covering nose, mouth, and eyes, in combination with other factors, determines the appropriate gas sampling method to use for CO2 measurement. The success of respiratory gas monitoring with therapies, such as NPPV, depends on understanding and controlling these factors.
Given these problems associated with monitoring respiratory gases from patients with masks, it is desirable to provide a mask with both mainstream and sidestream respiratory gas monitoring capabilities. Such a mask would be beneficial if it also minimized the added dead space and the pressure drop associated with the application of conventional gas monitoring approaches. Additionally, such a mask is beneficial if it also permits the effectiveness of therapies, such as NPPV, to be assessed and provides convenience and simplicity to the user, thereby encouraging greater use of such therapies.
Accordingly, it is an object of the present invention to provide a patient interface assembly for use with gas monitoring that overcomes the shortcomings of conventional gas monitoring approaches. This object is achieved according to one embodiment of the present invention by providing a patient interface assembly that includes a shell having a first opening and a second opening and a seal. The seal includes a first end portion coupled to the second opening of the shell, and a second end portion for sealing engagement with a face of a patient. The patient interface assembly also includes a mask attachment coupled to the first opening of the shell. The mask attachment has a mask connection section coupled to the opening of the shell, an airway adapter section for use in measuring a respiratory variable, and a breathing system connection section adapted to be coupled to a to a patient circuit.
It is a still further object of the present invention to provide a patient interface assembly that includes a shell, a seal coupled to the shell, a conduit coupled to the shell, and a gas measurement site disposed on the conduit, the shell, or both, wherein the gas measuring site includes a window.
Yet another object of the present invention is to provide a respiratory gas analysis system that includes a mask having an opening and a mask attachment operably coupled to the opening in the mask. An access port is defined in the mask, the mask attachment, or both. A sampling tube is in fluid communication with an airway of a patient through the access port. A transducer is secured to the sampling tube, and a processor communicates with the transducer. The processor calculates at least one respiratory parameter using the signal from the transducer.
It is a further object to provide a method of sidestream respiratory gas analysis that includes applying a mask assembly to a patient; placing a sampling tube in fluid communication with an airway of a patient; communicating a flow of gas from the patient via the sampling tube to a sidestream gas measurement assembly; and analyzing the at least one parameter using the sidestream gas measurement assembly.
These and other objects, features, and characteristics of the present invention, as well as the methods of operation and functions of the related elements of structure and the combination of parts and economies of manufacture, will become more apparent upon consideration of the following description and the appended claims with reference to the accompanying drawings, all of which form a part of this specification, wherein like reference numerals designate corresponding parts in the various figures. It is to be expressly understood, however, that the drawings are for the purpose of illustration and description only and are not intended as a definition of the limits of the invention. As used in the specification and in the claims, the singular form of"a", "an", and "the" include plural referents unless the context clearly dictates otherwise.
The particular embodiments described herein are intended in all respects to be illustrative rather than restrictive. Alternative embodiments will become apparent to those of ordinary skill in the art to which the present invention pertains without departing from its scope.
Mask attachment 200 provides an "L" shaped conduit or 90� elbow coupled to the mask shell. In an exemplary embodiment, the mask attachment is rotateably coupled to the mask shell. It is to be understood that the invention contemplates other configurations, shapes, and angles for the mask attachment, such as straight (180�) and 45� angle.
As noted above, mask 104 includes a shell or body portion 120 to which seal 110 is affixed. Shell 120 also defines an opening 170, or other suitable means, for connecting mask 104 to mask attachment 200 and to a supply of gas (not shown) for administration to a patient. Shell 120 further includes two outwardly projecting strap retaining tabs 130 and an upwardly projecting strap retaining tab 150, each having suitable elongated apertures that receive and retain suitable conventional head straps (not shown) for retaining the patient interface assembly to the face of a patient. An optional pressure port 160 with a cap 162 for sealing the port is shown. Port 160 may be used for pressure monitoring, for example, for providing feedback to a therapy delivery system. Port 160 can also be used for delivering a flow of gas, such as oxygen, to the user. It is to be further understood that the shell and seal member can be any conventional shell and seal member known in the art.
Referring to
Airway adapter section 250 provides a conduit for communicating gas between mask connection section 220 and breathing system connection section 280. A swivel connection 278 couples the airway adapter section to the breathing system connection section. Additionally apertures 251 and 252 provide optical access to the gas stream within this section. Breathing system connection section 280 provides a conduit for communicating gas between the airway adapter section and breathing circuit. Breathing system connection section 280 couples the patient interface assembly to a therapy device, such as a ventilator or pressure support system.
In the exemplary embodiment, the interior surfaces of the mask connection section 220 are tapered such that the flow between the mask connection section 220 and airway adapter section 250 remains relatively undisturbed. Similarly, during exhalation, this tapering permits a measurement that is more representative of the patient's expiratory gas and less diluted by gas mixing to be made. Additionally, tapering reduces the pressure drop of the mask attachment so that therapy, such as NPPV, can be administered more efficiently and with less resistance during the exhalation and inhalation phases.
In the exemplary embodiment of this invention, opening 232 is provided in mask connection section 220. A grommet 234, which contains an interior passage 230 and cap 235, is assembled to opening 232. Interior passage 230 serves as an access port so that a tubular structure, such as a catheter, can be placed within the mask and, if desired, placed into the nares or oral cavity of the user without breaking the seal between the mask and the users face and interrupting the current therapy. The present invention contemplates using the access port for other applications, such as, but not limited to, the placement of a gas sampling catheter, a suctioning catheter, a flexible bronchoscope, or a catheter for respiratory drug delivery in or near an airway of the user.
The mask attachment is preferably connected to the mask via a coupling 221 in such a manner to allow rotation between the mask shell and the mask attachment. This permits easier access of the caregiver to the patient's face that may otherwise be partially obstructed by the breathing tubing of the breathing circuit, as well as allows the access port to be positioned to permit more convenient placement of a catheter or bronchoscope. Port 232 also permits the positioning of a tubular structure close to the nares or oral cavity of the user, thereby enabling more efficient collection of the patients expiratory gas. The access port can include a plug with a cover or the plug can be made of an inexpensive material, which can be easily punctured and will reseal upon removal of the catheter, such as materials used in vascular access ports. Port 232 is dimensioned such that known gas sampling, suction, or delivery catheters and bronchoscopes can fit through the port leaving a sufficient clearance, e.g., greater than 6 mm diameter.
The central portion of airway adapter section 250 is generally parallelepiped with a flow passage 210 extending through the mask connection section, the airway adapter section, and the breathing circuit connection section. The mask connection section and breathing system connection section are preferably axially aligned with the airway adapter section. Airway adapter section 250 provides a seat for a securably removable transducer 50. (See
One suitable CO2 gas sensor suitable for use as transducer 50 is the CAPNOSTAT� brand of infrared (IR) sensor offered by Respironics Novametrix of Wallingford, Conn. It can be appreciated to one of ordinary skill in the art that the purpose of the airway adapter section is to provide access to the flow of gas within the conduit, so that components of the gas may be measured. As such, any gas sensing device, whether it is securably removable, or affixed to, or integrated with the airway adapter section may be used.
Breathing system connection section 280 connects the airway adapter section with the tubing of the breathing circuit. Generally, the outer diameter of a cylindrical connector 282 of the breathing system connection section is sized and tapered to conform to existing breathing system circuit connector standards. The breathing system can be coupled to a single limb or dual limb breathing circuit. With a single limb breathing circuit, an exhalation valve is provided at or near the mask. With a dual limb breathing circuit, a 'Y' or 'T' piece with separate expiratory and inspiratory limbs is coupled to the breathing system connection section.
To facilitate the measurement of constituents of the gases in flow passage 210, infrared light radiation passes through an infrared-transparent portion of the airway adapter section. This infrared-transparent portion may be realized by means including, but not limited to, apertures with infrared transparent windows or molding the airway adapter portion of infrared transparent material. In the exemplary embodiment, apertures 251 and 252 are formed in airway adapter section 250. Apertures 251 and 252 are covered by first and second axially aligned windows 253 and 254, respectively. Windows 253 and 254 preferably have a high transmittance for radiation in at least the intermediate infrared portion of the electromagnetic spectrum. The substantial axial alignment of first window 253 and second window 254 allows an infrared radiation beam to travel from an infrared emitter in one leg of transducer housing 50 transversely through airway adapter section 250 and through the gases flowing through flow passage 210 to an infrared detector in the opposing, substantially parallel leg of transducer housing 52. With transducer housing 52 assembled to the airway adapter section, these apertures are aligned along an optical path 259. Thus, an infrared radiation beam can travel from the infrared radiation emitter unit in transducer housing 52 transversely through airway adapter section 250 and the gas or gases flowing through airway adapter flow passage 210 to an infrared radiation detector unit of transducer housing 52.
The internal configuration and design of an exemplary infrared detector, which preferably monitors, in real time, the amounts of respiratory gases, such as CO2, and N2O or anesthetic agents in the respiration of an individual, is thoroughly discussed in U.S. Pat. No. 5,616,923 (hereinafter "the '923 patent"). It is understood that infrared CO2 monitor devices, such as those disclosed in U.S. Pat. Nos. 4,859,858 and 4,859,859 and in the '923 patent, as well as other gas detection devices, are contemplated for use in transducer housing 50. The other gas detection devices suitable for use in the present invention include, but are not limited to, (a) devices that monitor gas using chemical based techniques, such as luminescence, (b) devices that monitor gas using electrochemical and physical methods, such as Raman spectroscopy, and (c) devices that monitor gas using nanotube based methods. In addition to one or more infrared sensors, the infrared detector of the present invention can include any combination of other components, including a reference sensor, optics (e.g., lenses, filters, mirrors, beam splitters, etc.), coolers, and the like. The infrared signals detected by infrared detector can be ratioed to provide a signal accurately and dynamically representing the amount of CO2, N2O or an anesthetic agent flowing through airway adapter section 250.
Referring to
Referring to
As shown in
Mask attachment 201 is generally similar to mask attachment 200 except that in the embodiment shown in
The embodiments of the patient interface assembly, including the mask and mask attachment, shown in
A grommet 334 is inserted into an opening (not shown) defined in cap 331. A grommet cap 335 is provided to cover the opening in the cap by sealing over an opening in the grommet.
A flapper valve member 333, manufactured of a flexible material, such as rubber, serves as the entrainment valve and blocks the opening in cap 331 when the system is pressurized. The flapper valve functions as the entrainment valve in the same manner as the entrainment valve discussed above.
If it is desired to divert a sample of gas from within the mask to mask attachment 440, the mask attachment includes a gas collection adapter 319 positioned within the mask attachment. A tubing connector 324 is provided at one end gas collection adapter 319. Gas collection adapter 319, which may be made of rigid or flexible material, comprises a conical structure 322 with a central hole 325 to channel the flow of gas into a tubular portion 321 of the gas collection adapter. The length of tubular portion 321 of the gas collection adapter is selected so as to position conical structure 322 near the patient's oral cavity and nares to capture the user's expiratory gases. The present invention also contemplates that tubular portion 321 is movable relative to the mask attachment, as indicated by arrow B, to allow the end of the tube to be positioned near the user's nares. Friction between the tube and the grommet hold the tube in place. In addition to a conical structure, other structures for gas collection, such as prongs, are contemplated for use with the gas collection adapter. A flexible structure that may be positioned at or near the user's nares is also contemplated.
A ring or tabs (not shown) are provided on a distal end of tubular portion 321 to permit easy assembly of the tubular portion with tubing connector 324 by having the tabs mate with slots, tabs, a rim, or other mechanical fastener (not shown) in the tubing connector. An inner lumen of tubing connector 324 includes an internal grommet to permit easy connection to a conventional gas sampling tubing. Mating the outer surface of the gas sampling tubing to the inner lumen of the tubing connector minimizes the restriction of gas flow through the tubing connector and to the gas sampling tube (not shown) that connects to the tubing connector. Other means to connect the gas sampling tubing to the gas collection adapter, such as external barbs, are contemplated. Also, different tubing connectors with different features, and which the user can configure, are contemplated.
Similarly, the mask attachment may be combined with breathing circuit configurations known in the art, including but not limited to single limb or dual limb circuits. The mask attachment may be combined with valving known in the art, such as exhalation valves used in a single limb circuit. Other conventional components, such as humidifiers, bacterial filters, heaters, exhaust assemblies, pressure relief valves, flow sensor, temperature sensors, humidity sensors, and sampling ports can be provided in the mask, the mask attachment, or the breathing circuit.
Other respiratory gases, including trace respiratory gases, that are available endogenously, such as NO and CO, may be measured using a securably removable transducer or an integrated transducer provided on the airway adapter section of the mask attachment. Therapeutic gases such as NO, Oxygen, and Heliox (Helium and oxygen) may be measured. An O2 mainstream sensor, when combined with the administration of oxygen as the therapeutic gas, may provide more accurate O2 administration.
Additionally, the airway adapter section may be combined with, or optionally include, a flow measurement component. The flow measurement component may include pressure taps on each end of the airway adapter section that using a differential pressure measurement flow can be estimated. The pressure drop due to the cuvette although small would be sufficient to permit a reasonable estimate of flow to be made. For example, flow may be measured using pressure taps and differential pressure measurements as known in the art as well as optical methods using the apertures in the airway adapter section.
Although the invention has been described in detail for the purpose of illustration based on what is currently considered to be the most practical and preferred embodiments, it is to be understood that such detail is solely for that purpose and that the invention is not limited to the disclosed embodiments, but, on the contrary, is intended to cover modifications and equivalent arrangements that are within the spirit and scope of the appended claims. For example, it is to be understood that the present invention contemplates that, to the extent possible, one or more features of any embodiment can be combined with one or more features of any other embodiment.
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|Nasal mask for carbon dioxide gas measurement
|Jun 30, 2008
|Apr 19, 2011
|Nihon Kohden Corporation
|Nasal mask for carbon dioxide gas measurement
|May 12, 2010
|Jul 24, 2012
|Hsiner Co., Ltd.
|Respiratory mask device having improved head strap connectors
|Aug 11, 2006
|Mar 1, 2007
|Ric Investments, Llc.
|Mask mounting mechanism
|Aug 10, 2006
|Mar 1, 2007
|Horne Marilyn B
|Filtering and humidifying face mask
|Jul 6, 2007
|Aug 21, 2008
|Nihon Kohden Corporation
|Nasal mask for carbon dioxide gas measurement
|May 12, 2010
|Nov 17, 2011
|Hsiner Co., Ltd.
|Respiratory mask device having improved head strap connectors
|May 11, 2011
|Nov 15, 2012
|Varga Christopher M
|Carbon-dioxide sampling device for noninvasively measuring carbon dioxide in exhaled breath
|Oct 3, 2014
|Apr 9, 2015
|Nihon Kohden Corporation
|U.S. Classification
|128/206.21, 128/205.25, 128/206.28, 128/204.23
|International Classification
|Cooperative Classification
|European Classification
|May 3, 2006
Owner name: RIC INVESTMENTS, LLC, DELAWARE
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:SCARBERRY, EUGENE N.;JAFFE, MICHAEL B.;HO, PETER CHI FAI;REEL/FRAME:017835/0304
Effective date: 20060501
|Jan 28, 2013
|Fee payment
Year of fee payment: 4
|Mar 17, 2017
|Maintenance fee reminder mailed


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(Last of 3 Parts)
Every election the PPCRV (Parish Pastoral Council for Responsible Voting) and the well-meaningcitizensdo not miss the chance to remind usand persuade the voters to choose their candidatesand vote wisely. Every time though, in Bohol at least, the voters proved that money is still the best guide and mover in choosingthecandidate to vote for.
This time 'One Good Vote' has been launched but again knowing the ningas-cogon mentality of the Filipinos, it could be another one movement dying of a natural death even before its true value could be digested, appreciated and followed.
So is the situation hopeless? Is it enough reason to say "I surrender?" God the Son (to give our column a touch of the Lenten season), became man and died on the cross to save man, the sinner. Any movement like the One Good Vote can never give up especially before it could take off. Jesus never gve up even at the expense of His own life.We cannot give up and we need more active support from every one.
I discussed in the last two issues of The Agora the Sustainable Development Goals (SDGs) that the UN has come up with for the whole world to move towards and push for programs to attain them. And so we are adding these as the reckoning points from where to base our judgement in voting. Any candidate for national election should be grounded on these issues or we fail in our international commitments. But more than that, we will fail our own people.
So I said we ask our candidates what they are going to do with these goals. How are they going to direct their programs to addressthe issues raised by the whole world and help attain the goals? I was through with the four (4) goals. Now what are the rest?
Here they are: Goal No. 5. "Achieve gender equality and empower all women and girls." Statistics showed that in Southern Asia, only 74 girls were enrolled in primary school for every 100 boys in 1990. By 2012, the enrolment ratios were the same for girls and for boys.In 46 countries, women now hold more than 30% of seats in national parliament. But women in Northern Africa hold less than one in five paid jobs in the non-agri sector.
Goal No. 6: " Ensure availability and sustainable management of water and sanitation for all."In 2015, 91% of the global population is using an improved drinking water source, compared to 76% in 1990. However, 2.5 billion people lack access to basic sanitation services, such as toilets or latrines.Each day, an average of 5,000 children die due to preventable water and sanitation-related diseases.
Goal No. 7. "Ensure access to affordable sustainable and modern energy for all."1.3 billion people – one in five globally – still lack access to modern electricity.Three (3) billion people rely on wood, coal, charcoal or animal waste for cooking and heating.Energy is the dominant contributor to climate change, accounting for around 60% of total global greenhouse gas emissions.
Goal No. 8: "Promote inclusive and sustainable economic growth, full and productive employment and decent work for all."Global unemployment increased from 170M in 2007 to nearly 202 M in 2012, of which about 75 M are young women and men.Nearly 2.2 billion people live below the US$2 poverty line.470 M jobs are needed globally for new entrants to the labour market between 2016 and 2030.
Goal No. 9: "Build resilient infrastructure, promote inclusive and sustainable industrialization and further innovation."In developing countries, barely 30% of agricultural production undergoes industrial processing. This suggests great opportunities for developing countries in agribusiness.Manufacturing is an important employer, accounting for 470M jobs (16%). Industrialization's job multiplication effect has a positive impact on society. Every one job in manufacturing creates 2.2 in other sectors.
Goal 10: "Reduce inequality within and among countries."Children in the poorest 20% of the population are still up to three times more likely to die before their fifth birthday than children in the richest quintiles. Women in rural areas are still up to three times more likely to die while giving birth than women living in urban centres.
Goal 11: "Make cities and human resettlements inclusive, safe, resilient and sustainable." Rapid urbanization is exerting pressure on fresh water supplies, sewage, the living environment, and public health.Cities have the potential to optimize energy efficient by reducing energy consumption and adopting green- energy systems. In Rizhao, China , a solar powered city, 99% of HHs in its central districts, use solar water heaters.
Even just for these 11 SDGs, surely, our nationalcandidates must have something in mind to commit to be done if we have to retain the respect of our neighboring countries. What are they going to do with these? The same questions can also be asked of our local candidates. After all, they will be the implementing arms of the national government.
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Need a TSH Test in Dodge City, KS? Simply order online 24/7 and get a fast, affordable TSH Test at a lab near you (Find More Locations):
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Carpet Cleaning $40.00
2 rooms $39.95.
We have 28 years experience family owned and operated. Truck mounted equipment and professional chemical products!!! Call us today, we do clean tile & grout, cars furniture etc.
Don't forget to mention to you seen Sara's ad on HireRush to receive 1 room deodorized for free with a minimum of 2 rooms cleaned!!!!!


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7 of Pentacles
The 7 of Pentacles says you have been working very hard towards your goals. Pentacles often signify financial moments in your experience, and so if that is the case then know that you have been making all of the right decisions and move so far, and your hard work will pay off. It's time to stop for a moment however and assess your progress, and how you can use that to your advantage in the future. If this card represents love or relationships, a small break or separation may be in your experience, but this is not the ending of a relationship. It may just be a quiet period as well where communication slows down for whatever practical reason. Maybe one of you is on vacation, or traveling, and you are merely going through an assessment phase until you can be united again.
In the 7 of Pentacles we see a man pausing to look at the fruits of his labour. Pentacles represent money and work ethic, and practical things like messages and paperwork. They also often reflect our higher states of consciousness as well. They are grounded symbols, Symbolism a down to Earth approach is favored over an emotional one. In this card, the worker bee has stopped what he has doing and is taking stock of his progress. It is a review card, a reflection card, and a card that your work ethic or the elements in your situation that you have been working on are piling up, in your favor. This is not an action card, but rather one that says it is time to take a step back and look over your progress thus far before moving forward.


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If you are looking for a cabin or a significant amount of storage space, then this 12' barn kit shed will be a great addition to your yard.
With it's second floor loft which has 4'-6" headroom there's enough space for a sleeping
area The first floor, with its high side walls, has plenty of room to add
shelving for even more versatile storage.
The siding has vertical grooves that
give it an attractive plank look. They are primed so that you can paint them the color
of your choice (latex acrylic paint recommended). The siding is treated and
prevents fungal decay and insect damage. It is manufactured with wood
strands that are pressed into a resin saturateds substrate making it superior to
plywood. The Best Barn wood shed kit components fit easily into place with
no special tools or skills required. For extra strength to the trusses, metal hurricane
truss hangers are povided to secure trusses to the exterior walls. The
building picture depicts the 12'x20' size for this model.
OPTIONAL FLOOR: Choose between two floor designs in order to best suite your needs. If
you have a preexisting foundation, cement slab, blacktop or gravel base, the
standard floor kit works best. you can use bricks or patio stones to level the 2x4
treated framing. This floor includes treated 2x4's 16" o.c. and 5/8" OSB.
If you would prefer to set your foundation for the Arlington 12x16 shed directly on grass, the deluxe floor kit
would be floor for you. It includes 4x4 treated runners and give support to the
floor joists. Raising the foundation above the ground, the 4x4's allow air to flow
and eliminate moisture. This kit includes 4x4 treated runners, treated 2x4's 16"
o.c. and 3/4" plywood. All nails are included, and the floor does require cutting and assembly, also the floor sheathing is not treated.
Competitive Edge Products, Inc. is an authorized distributor of Arlington
Best Barn Kit.
Find a Cheaper Price?
Let us know by emailing us at
Please be sure to include your zip code and we'll beat the price. The competitor
must be a legitimate company.


text:
Product details
Hart's hexagonal shaft, magnetic tipped screwdrivers are designed for use in the most demanding applications. Featuring a quick identification colour coded cap and an ergonomic hand grip, these screwdrivers are perfect for both the professional & home user. Each screwdriver contains a unique SVCM steel shaft which allows a slight flex under high torque applications, which extends the screwdrivers life. Unique removable & replaceable lid allows for quick installation on a wall or in a vehicle for storage & easy-access. This model includes both a long and stubby multi-bit driver with a wide range of drilling bits for specialty applications.
- Features: SVCM Steel provides additional flexibility to increase snapping resistance
- Includes: Hard case with removable lid
- Additional information: Wall mountable case
- Dimensions: (H)390, (W)310, (D)45mm
- Colour: Red & black
- Material: SVCM Steel
- Guarantee: Limited Lifetime Warranty
- Tip Size: Various


text:
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50% discount applicable on any remaining August 2017 dates!
30% discount applicable on all other 2017 dates
|Max no of Guests
|No of Bedrooms
|No of Double Beds
|No of Single Beds
|No of Bath/Shower Rooms
|Walk to Town Centre
|8-10 mins
Villa Alisia is a substantial and beautifully maintained 4-bedroomed villa in a sought-after and peaceful location, an easy and level 8 minutes' walk from Kalkan's town centre.
This stylish air-conditioned villa has been very popular with our guests and benefits from having stunning sea views. It's also close to the prestigious Regency and Likya Residence Hotels.
Villa Alisia offers extremely spacious accommodation to suit families or groups of up to 8 guests.
The accommodation is laid out as follows:
Ground floor:
The villa has a large open plan living, dining + kitchen area (around 60 square metres in total).
The modern kitchen is well equipped for self-catering and has applicances such as dishwasher, large fridge-freezer, microwave, washing machine, electric oven with gas hob and extractor.
The dining area seats 8 guests.
The living area has plenty of comfortable seating plus LCD satellite TV and DVD player. An bluetooth speaker is also provided to enable you to stream your favourite music.
WiFI internet access is provided for guests' use.
From the living area, large glass doors lead out onto the pool terrace.
The villa has four bedrooms as follows:
The first floor of the villa is home to a double bedroom plus a a twin.
The double bedroom benefits from having an extremely spacious terrace-style balcony that's furnished with reclining chairs. This balcony adds great outside space and has great sea views.
The twin bedroom on this level has two balconies (with partial sea views).
Each of these bedrooms has an en-suite shower room.
The next floor of the villa houses a huge master suite (some 25 square metres) with dressing room and en-suite shower room with twin basins. This bedroom has a large furnished balcony with breathtaking sea views.
The villa's top floor has a twin bedroom with a roof terrace that has amazing sea views.
Outside the villa:
Villa Alisia has a very attractive sun terrace with freshwater pool and plenty of sunloungers and parasols. The terrace also has a lovely shaded al-fresco dining area to seat 8 guests plus a stone built BBQ.
Points to note:
Previous guests' comments from a stay in September 2012:
'I stayed here with my husband, son and his girlfriend and my sister her partner and her two grown up children recently. we had the most amazing holiday. The villa was stunning. It was big enough for us to not get on top of one another and it had everything we needed, the pool was fantastic and the views from the villa were breathtaking. All the rooms were lovely but I bagged the top floor suite and it was very luxurious and the bed was huge . The location of the villa was good too it was very quiet. Although it was a bit hilly to walk to the harbour it was manageable for us but taxis were only a couple of pounds for anyone who may have struggled. We all loved Villa Alisia and Kalkan itself and we would most definitely go back.'
50% discount applicable on any remaining August 2017 dates!
30% discount applicable on all other 2017 dates
Prices are for the villa per week (maximum number of guests - 8).
View Villa Alisia - Kalkan in a larger map


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|Reviews for L Tastes Like Chocolate
| 0XxProfessionalFangirlxX0 chapter 1 . 4/30/2011
Really awesome. Could you update? :) Great job!
| doomedpassion chapter 5 . 4/27/2011
I love the plot and your writing style is good...and the crow imagery was awesome...was it a warning for L or Light? It goes both ways no? and I really want you to continue this...and you keep suggesting that Light could be falling in love with L...I want to read the conclusion! Please don't abandon this!
| Moonphase chapter 5 . 12/3/2009
who dos Takami play in DN? I know Host Club but I don't know the voice actors so-
I hope you don't give up on this fic. I really like it. L is so cute! I love the way you keep Light in character, its really hard to do, especially in stories of love and/or redemption because Lights character is so single minded and arrogant. You're doing a good job. Can't wait to read more
| Moonphase chapter 4 . 12/3/2009
I always see L as a uke. I never understand how he could be all sexually dominant when he's SCARED of just touching people! I think you've done a good job :)
| Nichigo chapter 5 . 12/26/2008
One of the first stories I loved an uke L. *swoon Update soon!
| Rai Vinn chapter 4 . 7/30/2008
Oh! Thank you so much for making L the uke! L as the seme is just.. Not right. You make him look like a little innocent puffball with big eyes, and I love you for it. There's just one story (In my opinion) that has L look good as a seme, and that's Light Up My Darkness. Read it if you can, its really a good story. And keep up writing this one, I'm hooked!
| fouloldron chapter 5 . 7/14/2008
Very interesting.
I think L's a better actor than Light gives him credit for. And I think it likely that L has false documentation set up on the met database, which he has alarmed incase anyone looks at it.
Thanks for the update. :)
| Leki chapter 5 . 7/10/2008
So far, I'm still faithful, even after you put off this fanfic for so long. _~ L Tastes Like Chocolate is cute, and I can't wait to see what will progress between L/Light, and not to mention Misa!
Quite a good comeback for Light - There to talk about them, without her in the picture.
Now here's some motivation... Use it, and give us more chapters!
| Dozing Dead chapter 5 . 7/10/2008
As long as you don't drop this, I'm perfectly fine with you writing another fanfic. I'm so freakin addicted to this story, I would just shatter if you stopped! D: At first, since it was taking you so long to repost, I thought it was on a hiatus and was like "NOES! *sob cry*"
I was super happy to see the email alert, and I would love to see another one soon. Your writing is amazing and poetic, fascinating to read and leaves me curious to your next metaphor or simile.
And I forgive you. For now. But if this fanfic dies . . . *ahem* Just don't let it die, mmkay?
Update soon, I'm ever waiting for the next chapter.
| Synonymous Brian chapter 5 . 7/9/2008
OMG, I literally LOLED at the Tamaki reference, and I love how they have the same voice actor XD Update soon this time please! _
| C Elise chapter 5 . 7/9/2008
very great story! I think your characters are very interesting
| HuckFinnFan chapter 5 . 7/8/2008
I will never forgive you! Just kidding I forgive you :D
I love this story so much that when I saw that it was updated I literally squeeked with joy :D
please update soon!
I can feel that this is going to be a Light-seme story but it'd ve awesome if it was L-seme but whatever its your story and I'll love it no matter what
rabid L fangirls unite :D
haha that was tackiest thing I ever said XP
| Aaliyah Higurashi Reborn chapter 5 . 7/8/2008
I'm so glad to hear from you after so long! Your story just keeps getting better && better && I hope that you get to write more soon.
So much for Raito's brilliant plan. :P lol
A Rabid Fan,
~!~Aaliyah Higurashi Reborn~!~
| Nusku chapter 5 . 7/8/2008
oh my...Misa is very...um stupid...update soon
| Hey chapter 5 . 7/8/2008
Haven't heard from you in a while. Well, no matter, good chapter as always. _ Aww, I was hoping Raito would fall for L... Maybe he will see how much L really loves him and loves L back? Maybe? Update soon.


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These Hot Dads Bring A Whole New Meaning To DILF
In Southern California the sun is hot and so are the men. Watch as these furry muscle dads glisten with sweat and splooge. The gym works up muscle bear Brad Kalvo and Peter Rough. Brad gives Peter a new kind of workout with his squirming tongue and big fat stick. Hairy Scotty Rage and Victor West get each other's motor running in a garage. Peter and Derek Parker blow off their personal trainer before blowing each other. The fur flies when Brad and Josh Thomas get it on after a long day.
Producer: Pantheon Productions, 96 minutes + 0 minutes DVD extras
Director: Peter Romero
Starring: Brad Kalvo, Peter Rough, Scotty Rage, Victor West, Derek Parker, Josh Thomas


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On Sunday Mannkal interns from across Canada came together in the nation's capital of Ottawa to participate in the Ottawa Enrichment Program and the Manning Centre Conference.
The scholars met with Mannkal Director Andrew Pickford to discuss our experiences at the various think tanks where we were based and to consider the challenges faced of implementing policy in both countries.
The discussion on policy implementation and how Australia and Canada could further cooperate in the future continued at the Australian High Commission with a senior policy officer and the Deputy High-Commissioner.
Australian Government departments communicate regularly with their Canadian counterparts, and we heard that the role of the High Commission is reduced as diplomats would usually facilitate these types of interactions in other countries.
We were lucky enough to have lunch with Tom Kmiec (Member of Parliament for Calgary Shepard) who had an extremely impressive knowledge of defence policy not only in Canada but also Australia. We were told that Canada surprisingly has attempted to model and implement some Australian policies including the deregulation of our agricultural industry (which still has a long way to progress) and the 457 skilled immigration policy.
This included sending teams of experts to our country to study the programs.
The Canadian Department of Finance hosted a roundtable discussion on Tuesday afternoon where the guest speaker was Andrew Pickford. The topic of discussion was "China's Grand Strategy and Energy: Markets, Infrastructure and Global Ambitions" which provided a lively debate.
Apart from government employees, there were experts from think tanks in Canada and the United States and financial analysts. Andrew's knowledge was very impressive as was the ease in which he was able to apply detailed energy policy and economic concepts to the Western Australian and Canadian contexts.
Attending question period at the Canadian Parliament has been a highlight of the time spent in Ottawa for myself and the other interns. Because of bilingualism sitting in the public gallery required the use of a small speaker which provided translations of parliamentarians who chose to speak in French.
It was interesting to see that Canadian politicians were even worse than Australian MPs at completely failing to answer any questions they were asked and was surprising to see that after answering four opposition questions, Justin Trudeau played on his phone for the remaining portion of question period.
The Atlas Network provided exceptional media training which also had practical advice for everyday debates and how small changes can improve your image in the press, but also in the workplace. Following the Atlas training, the Manning Centre hosted a variety of different speakers who were experts in running political campaigns not only in Canada but also the United States and Australia.
I found the continuing importance of mail surprising, when combined with online targeting and emails the development of how election campaigns are run has changed rapidly in the last few years.
I'm most looking forward to the Canadian Conservative Party Leadership debate hosted at the Conference on Saturday. Fourteen different candidates will discuss various topics from reducing the deficit to the carbon tax to vie for new party members who are crucial in the vote which will take place later this year in the build up to the 2019 federal election.
The candidate I find most interesting is Kevin O'Leary who many people will know as 'Mr Wonderful' from the American television series Shark Tank. O'Leary is labelled as Donald Trump light, although he's currently leading in polling prepared by national newspapers, so it will be interesting to see if Canada will be captivated by the sweeping change that saw Trump elected south of the border.
As the interns rapidly approach their last week of our internships, there is a mix of emotions as we say goodbye to colleagues, new friends and a country that has been our home for the past three months. I'm sincerely thankful to Ron Manners and Mannkal for the opportunity to gain skills that will benefit my final studies, future career and the independence, resilience and confidence I've gained as a person during this experience.
We've had our beliefs challenged and have been able to challenge others. I thoroughly look forward to being able to put our new skills to use on our return to Australia, especially as our generation seeks to reduce government debt, red tape and interference in our personal lives.


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Aspen Park Pharmaceuticals acquires novel oral drug to treat castration resistant prostate cancer
Sep 30, 2015, 09:13 ET from Aspen Park Pharmaceuticals, Inc.
NEW YORK, Sept. 30, 2015 /PRNewswire/ -- Aspen Park Pharmaceuticals, Inc., a private company, today announced that it has acquired worldwide rights from The Ohio State University, through the Ohio State Innovation Foundation, to APP-111. APP-111 is a first-in-class oral, antitubulin targeting agent for the potential treatment for the form of castration resistant prostate cancer that does not respond or becomes resistant to currently available androgen receptor antagonists like XTANDI (enzalutamide) and testosterone reducing agents like ZYTIGA (abiraterone acetate and prednisone).
"It has now become clear that there is significant cross-resistance that occurs between androgen receptor antagonists (enzalutamide) and testosterone reducing agents (abiraterone) in men with metastatic castration resistant prostate cancer. So after a patient fails one of these drugs, a new drug with a different mechanism of action is required," said Dr. Mario Eisenberger, R Dale Hughes Professor of Oncology and Professor of Urology, The Johns Hopkins Hospital. "Cytotoxic agents that target tubulin remain the most effective agents against advanced prostate cancer, but currently they can only be administered IV and have significant side effects like neurotoxiticity and myelosuppression. An orally available agent, like APP-111, that targets tubulin would be expected to have activity against prostate cancer and would be an important addition to the armamentarium for treatment of castration resistant prostate cancer."
APP-111 is an orally available tubulin targeting agent that has demonstrated efficacy in preclinical studies against hormone sensitive, castration resistant, as well as taxane resistant prostate cancer. Further, in preclinical studies, it appeared to have less peripheral neurotoxicity and myelosuppression than currently available antitubulin cytotoxic agents. This high potency, small molecule drug binds to microtubules and prevents polymerization which has been shown to not only block cell division and induce cell death, but also disrupts androgen receptor signaling required for tumor growth. Since microtubules are involved in the transport of the androgen receptor to the nucleus, agents that target microtubule interactions with the receptor have the potential to serve an important therapeutic role in treating advanced prostate cancer. APP-111 is expected to be in Phase1a/1b clinical studies in late 2016. APP-111 has over 21 issued, allowed, and pending patents. These patents also cover hundreds of potential analogue back-ups across multiple structural templates. APP-111 is a platform technology that may have activity in other tumor types that have previously responded to taxanes or vinca alkaloids.
"We are pleased to acquire the rights to APP-111 and its analogues. APP-111 has tremendous possibilities and value. We are committed to develop APP-111, a novel therapy, initially for men with advanced prostate cancer," said Harry Fisch, MD, Chairman of Aspen Park Pharmaceuticals, Inc.
About Aspen Park Pharmaceuticals, Inc.
Aspen Park Pharmaceuticals, Inc. (www.aspenparkpharma.com) is a privately held therapeutics company that focuses on the development of prostate cancer and men's health therapies for important medical diseases and conditions. The prostate cancer and men's health therapeutics market is estimated to be $18 billion worldwide. Aspen Park Pharmaceuticals is developing late stage proprietary patented clomiphene formulations for the treatment of male infertility and hot flashes in men on hormone therapy for advanced prostate cancer. Aspen Park Pharmaceuticals is also planning to launch in the United States the PREBOOST™ OTC product for the prevention of premature ejaculation. Aspen Park Pharmaceuticals is headquartered in New York City, New York. For more information on PREBOOST™ OTC product visit www.preboost.com or more information on company at www.aspenparkpharma.com
SOURCE Aspen Park Pharmaceuticals, Inc.


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Say you meet this good guy and you two hit it off but after a few dates you find out his family is and has been involved with organized crime for 30 or so years. Is that a deal-breaker? He personally isn't involve and obviously you'd be in no physical danger yourself.
Most Helpful Girl
I dated a guy whose brother was in jail for stuff he did with a biker gang...
So.. yeah.. I could..
But with organized crime.. can you really say that I'd NEVER be in danger?
Could they not go after us, to get to your family?00|00|2


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[VIDEO] – Insane Super Drift by Vaughn Gittin Jr.
High speeds + slick tires = insanely long drifts!
High speeds + slick tires = insanely long drifts!
Bangin' the Gears: Welcome to Heartbreak. At some point nearly every gearhead is faced with the task of selling their hot rod, whether it be […]
The Burnout sits down with Kirsten Wright from MagnaFlow to talk about the exhaust system currently powering the RacingJunk/AED Performance 2014 Chevrolet Silverado giveaway truck.
We start our long haul on the 2014 Hot Rod Power Tour with a car show in Charlotte, North Carolina.
Learn how MagnaFlow helped give a unique voice to each of the cars in the upcoming movie 'Need for Speed'.


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So long story short, I'm dating a guy who is significantly older than me. I've always gone for older guys anyway, because I've always been more mature for my age and guys my age never really shared my same interests or generational likes (I like older music, movies, classic literature, fine dining and wine, going out and actually DOING stuff, and I've already owned 2 of my own small local businesses out of my home. I'm ambitious and independent and know what I want to do, as well as artistic and musically talented).
Anyway, the relationship with this man was not planned, neither of us really expected it to happen, it just kind of happened and our friendship developed into something more when we recognized our mutual attractions to one another and our common interests and complimenting personalities.
However, the age differences has been an issue for him in the sense that he's divorced with two kids, very vocal about politics and involved and well known in the community and is worried that if we were to be public that nobody would vote for him whenever he decides to run for political office because he's dating a woman 32 years younger than him (I'm 23, he's 55). His kids are his number one priority and concern, being he had them late in life and they are 13 and 8.
So we have some obstacles. We decided to just see where things go though and not worry about it and have been dating for about 2 months now. Last weekend we took our physical relationship to the next level with sex and I stayed over for the first time (which we were both excited about). I stayed over one night during the week too, which I didn't except to happen because he gets up so early in the mornings before work. He makes me coffee and the second time I stayed over, he told me to not rush out of the house because he was leaving for work, but to stay, hang out, watch TV, whatever I wanted to do and make myself at home. I see this as a big step in the direction of trust and a sign that maybe he's reconsidering his hesitations in the beginning to us having a real relationship.
We always enjoy the time we spend together. Lots of smiles, great conversations and laughter. He calls me endearing names, and confides in me about his concerns with his kids (I haven't met them yet) and yesterday he called me just because to tell me about his plans this weekend with his kids, ask about mine, remembered I have a job interview on Monday and said he'd call me on Sunday (my day off), and said "Have a lovely weekend, stay out of trouble, I'll talk to you soon honey".
He babbles/rambles often when we are alone together or when he leaves me a voice mail and told me the other night that the reason he rambles so much is that if he keeps talking he'll eventually make me laugh (aww!). He's also said once when we were cuddling "You laugh in all the right places, I like you".
I think slowly but surely, maybe he's falling for me but wanted some second opinions and view points, from guys especially.
I'd like to hear about any similar relationships


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Question: Massachusetts vs EPA focuses on reduction of greenhouse gas emissions
Massachusetts vs. EPA focuses on reduction of greenhouse gas emissions by new cars and trucks. But there are many strategies not touched upon in this case that will reduce vehicle emissions. Consider that in the next 30 years, 70 million new homes will be built in the United States alone. Find the Congress for the New Urbanism and PlaNYC. What reduction in greenhouse gas emissions takes place when people choose an urban, as opposed to an exurban, lifestyle?
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Answer to relevant Questions(a) Although in the United States there is no general "duty to rescue," other countries do have such requirements. In France, Germany, and Russia, for example, bystanders may not legally ignore a fellow citizen who needs ...1. Who might be hurt by English-only rules? Who tends to benefit? Can such rules create or reinforce stereotypes? 2. Articulate the kind of discrimination claim made by the plaintiffs in this case. What will they have to ...1. The image of David Lucas that emerges from majority Justice Scalia's description is strikingly different from the one that Justice Blackmun creates in his dissent. What are the two contrasting stories in this case? Do ...1. Describe the evolution from the "intrinsic product benefit" model for advertising and the "creative revolution". According to the authors, why did the change occur? 2. Research: Find an example of a community ...Talon-G is a rat poison made by ICI Americas and sold only to professional pest control companies. The poison was registered by the EPA and packaged in a container with EPA-approved labeling that displayed warnings ...
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Cuddle Uppets
Cuddle Uppets are blankets that are puppets. It's a blanket that cuddles and a puppet that plays. It's your child's warm fuzzy friend at night and playmate during the day.
The Claim
CuddleUppets blanket have 6 designs to choose from - Pink Poodle, Purple Monkey, Yellow Puppy, Green Crocodile, Lady Bug, Unicorn and Elephant. Each type can keep your child warm at night. During the day, there are many ways he can be entertained with the CuddleUppets. It can be a playmate he can interact with, bring along on trips or create puppet shows with.
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2 Visitors rate it 4.5 Stars
What are they?
Cuddle Uppets are cuddly blankets and stuffed puppets combined into one item. They are puppets with blankets for bodies. Kids can now have fun stuffed animals to play with during the day and soft blankets to sleep with at night.
How do they work?
Each Cuddle Uppet has a cute animal head and a fuzzy blanket body. They are basically snuggly blankets with adorable stuffed animal puppet heads. Children will have hours of fun spending time with their new cuddly buddy and theyll have a warm, soft blanket to fall asleep with at night. And all they have to do is put their hand through the blanket inside the puppet mouth to make it talk! Cuddle Uppets are real puppets that double up as the perfect blankets.
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Cuddle Uppet Options
There are seven different Cuddle Uppets to choose from! They include Pink Poodle, Purple Monkey, Yellow Puppy, Green Crocodile, Ladybug, Unicorn, and Elephant. Each Cuddle Uppet makes the perfect gift because theres so many different ways to keep entertained.
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Wise AdviceDo not buy Cuddle Uppets online before searching Amazon.
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Wise AdviceDo not buy Cuddle Uppets online before searching Amazon.
- Alternatives or the same items are always available and sometimes at lower prices.
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Fix this: 5 shortcomings in iOS that those who switch from Android would find annoying
0. phoneArena posted on 26 Aug 2014, 09:36
In the world of mobile technology, there seems to be nothing as polarizing as the battle between Apple's iOS and Google's Android operating systems. With fans ready to start a holy war over features that one platform 'borrowed' from the other…
This is a discussion for a news. To read the whole news, click here
1. AfterShock (Posts: 3698; Member since: 02 Nov 2012)
But all that money you'd think it'd be perfect in every thing it can or can not do.
I guess more not then do, still.
3. Mxyzptlk (unregistered)
Android has its shortcomings as well you know.
8. Scott93274 (Posts: 5403; Member since: 06 Aug 2013)
Like how it doesn't have an Apple logo on the devices. lol
99. Ashoaib (Posts: 3229; Member since: 15 Nov 2013)
if Jackie Chen is upset by switching from Android to ios then for sure ios is annoying
125. jshan (Posts: 200; Member since: 25 Dec 2011)
No like it sucking its memory and battery like monster ! Also getting lags so soon !! And still it's not the smoothest OS for the gaming like iOS .. And oh .. Many more .. Many more real matter things !!
130. Scott93274 (Posts: 5403; Member since: 06 Aug 2013)
Lag is a thing of the bast my friend, just because you keep saying it's still a problem doesn't make it so.
Also, iPhones have the worst battery life of any phone. Several Android phones can last multiple days and that's before Android L which will increase battery efficiency by 30%+, where as iPhone users are referred to as wall huggers. I believe that the iPhone 5 is actually getting a lot of bad press regarding it's craptacular battery.
You say that the phone is a memory hog? It can run on 512 MB of memory and yet, the standard Android phone has 2 GB of RAM, soon to be 3 GB. Why all the RAM? Because the Android OS is capable of doing so much more than the iPhone.
So far your points about how the iPhone is better than Android are false, so I'm just going to assume that you know nothing about tech, and simply in love with Apple. Which is fine. If you like the company and the products then why would care what I or anyone else says about it. But don't be rambling on and on about something you know nothing about.
14. AfterShock (Posts: 3698; Member since: 02 Nov 2012)
Jeez Mxyz, C'mon,
You are a legend among trolls here at PA,
I expect more from you, an your phone.
Edit to add a +1 to help you recover.
97. Ashoaib (Posts: 3229; Member since: 15 Nov 2013)
PA didnt mentioned file sharing issues on bluetooth, wifi direct, Usb on the go, cannot custom change the ringtone on the go, limited number of file attachments for email, cannot directly copy paste files to n from computer except images, everything needs itunes, no switching between the apps and you have to press home button everytime if you want to move between different apps, no prompt for choosing default application etc... the need for itunes is enough ennoying that we dont have to look on any other limitation
112. Mxyzptlk (unregistered)
You're in damage control lol.
35. GalaxyS5 (banned) (Posts: 430; Member since: 05 Aug 2014)
They are truly minimal compared to the craappy ios
45. dorianb (Posts: 612; Member since: 24 Oct 2012)
Agreed. I'm loike Android in all but one day, like the app(s) of the month, they'll figure out maybe they should do compainion pieces.
5 things missing/shortcomings from each OS that another does well. Win>Android>iOS
58. bigdawg23 (Posts: 462; Member since: 25 May 2011)
WP is not Better than Android or iOS. I have a Lumia 1020 as a spare devices that just got 8.1, its improved but still not up to Android and iOS.
75. rkoforever90 (Posts: 284; Member since: 03 Dec 2011)
wp is better than ios .
98. domfonusr (Posts: 570; Member since: 17 Jan 2014)
Agree that this should have companion pieces that list five shortcomings for Android, or for WP, or maybe for BlackBerry, too. I am not, however, fully agreed that WP>Android. I see it more like this:
for simplicity, iOS=WP>Android=BB
for functionality, Android>iOS=WP=BB
for smoothness, iOS=WP>Android=BB
for affordability, Android=WP>iOS=BB
for ecosystem, iOS=Android>BB=WP
for security, BB>iOS=Android=WP
How good each OS is for you depends on how you weight each factor. Something like that...
137. TinyTesla (Posts: 13; Member since: 25 Aug 2014)
for security, BB>iOS=WP>Android (my opinion)
In other things i agree.
155. domfonusr (Posts: 570; Member since: 17 Jan 2014)
Yeah, some of that is subjective to a degree. But once you have your take on things nailed out, you can really tweak the weight of the different factors. At weight 1 for everything in my model, there are 6 points up for grabs, and Android comes out with 2 points, WP and iOS each with 1 and a half, and BB with 1. Now, if I change the weights (say I'm an enterprise user who likes security with a weight of 2 instead of 1), then I can get Android and BB with 2 each, and iOS and WP with 1 and a half each. By the same token, I can change the weights (say I really like a smooth operational interface and simple out-of-box operation - so I give simplicity and smoothness each a weight of 2) so that iOS and WP each have 2 and a half points, Android has 2 points, and BB has 1. It becomes completely subjective based on the user's preferences as to which OS is better for them. Even the orders for each factor can be subjective to some degree - although at some level there will be professional analysis that supports a particular order for each factor group.
50. gregoryyy3 (unregistered)
Whoever wrote this article is such an android fanboy. And actually there is a clear all button in the notification center.. Victor H hands down is a retard
93. blazee (Posts: 414; Member since: 02 Jan 2012)
I have been reading articles on this website for about 3 years and vicotor H is definitely an apple fan
95. Ashoaib (Posts: 3229; Member since: 15 Nov 2013)
what are short comings of android as compare to ios? can you plz eloborate bcoz I switched from ios to android and I didnt find any...
126. kopkiwi (Posts: 71; Member since: 31 May 2013)
Thankfully nearly all of them are easily fixed due to it's open platform nature. Have a problem, without doubt there is an app, or a tweek that will sort it.
150. thelittleprince96 (Posts: 6; Member since: 26 Aug 2014)
Yes,it HAD.But after the release of Kitkat i think it's really close to flawless. iOS7 is far from flawless and iOS8 doesn't show any signs of improvement.
9. Duketytz (Posts: 534; Member since: 28 Nov 2013)
Android people is unlikely to switch to Apple and Apple fans will never know about these shortcomings after being trapped in their 'utopian' operating system.
24. bucky (Posts: 3134; Member since: 30 Sep 2009)
I tried the gs5 and the nexus 5 in the last 6 months. I went back.
54. Tritinum (Posts: 471; Member since: 06 May 2014)
kids in kindergarten can't really understand 5th grade maths problems
102. Ashoaib (Posts: 3229; Member since: 15 Nov 2013)
I can understand your problem, kindergarten example is a nice one... it is easy to memorize 1-10 digits instead of memorizing 1-100.... ios vs android is same 1 to 10 vs 1 to 100
67. tedkord (Posts: 14130; Member since: 17 Jun 2009)
That's not true. I know one guy who went from Android to Apple (granted he went from an old Eclair device a coupe of years ago), and I know two guys who went IOS to Android, dropping the iPhone for Note 2 and 3. They weren't trapped. (I feel bad for the one guy, his wife did the upgrade to the Note 3 for him and he lost his unlimited data. Now he's got that awesome screen for media consumption, and halfway through the month he can't use it.)
108. Ashoaib (Posts: 3229; Member since: 15 Nov 2013)
well I am an example on PA about switching from ios to android and never looking back.... I had omnia Hd and N82(both sybian). one of my friend purchased probably samsung star or something which had android in it, I checked that phone and said "WTH its a copy of sybian & a bad copy"... I didnt like android that time at all.... then I changed from omnia to nokia c7 and lost my n82... then changed from c7 to iphone 4 and I used iphone4 more than a year and then changed to iphone 4s which I also used more than a year... I was very happy with iphone & ios and I was an ifool too but one of my friend purchased note 2, when I checked it for a while I said to myself is this same android? no its not, it is amazing and soon I ditched my iphone and thanks God I am in peace since than... I started using PA and joined PA after some months so I will not be fooled again
87. androtaku (Posts: 242; Member since: 12 Dec 2013)
i have both device,i like both platform and i consider myself liberal unlike some annoying narrow minded arsehole who make the personal platform decision sounds like taliban treatment
113. strudelz100 (Posts: 646; Member since: 20 Aug 2014)
I switched from a Quad-core LG to an iPhone 5 because it was flat out faster at everything, especially web surfing, better camera and more stable battery life.
Sure more options is great but iOS continues to be extremely stable and fluid. The app store still gets exclusive titles and iTunes still has great selection for those willing to support artists and developers by buying their products.
It's also much more secure in general. Think about it. Android was created by a data and advertising company. Those aren't the people I want handling my every day information.
119. hallihallo.87 (Posts: 30; Member since: 07 Jul 2014)
Because you prefer nsa ;)


text:
Why you should attend? The Good Childhood Report published in September 2016 highlighted the increase in emotional and mental health issues experienced by young people. As a member of a schools' pastoral team, it is important that all staff can empathise and support individual students when they need additional help. This workshop will identify how staff can help the young people in their care. It will not make delegates a qualified counsellor, but it will provide strategies such as how to listen effectively and how to help young people choose better options in their lives.
Outline programme
Venue: Broadway House, Tothill Street, SW1H 9NQ
Cost: Member £200
Non-member £250


text:
I've used a lot of really great (and not so great) design-related products over the years, and this page exists to bring attention to the products that I depend on – and love – the most. Note that I'll be adding content to this page often, so be sure to check back on a regular basis to see what tools I'm using most frequently.
My core set of design tools
These three products are the ones I've been depending on for years, and each one of them has helped me tremendously. They have been integral part of building my business, and I depend on them each and every day to help me realize my ideas.
Photostore by Ktools.net
Long time followers of mine know that I've been running my own stock illustration store since 2007, and I could have never done it without Photostore from Ktools.net. Although my store is currently offline for a complete reorganization and overhaul (it will be back), I've had great success selling my own images with this pre-built photo selling script. I've tried a lot of competing products over the years, and none of them work right out the box like Photostore does. It just works. And the best part? Jon and Jeff (the guys behind ktools.net) stand behind their product 100% and offer some of the best customer support I've ever experienced online. That is very important, as it allows me to focus all my efforts on content creation instead of having to deal with website issues.
FormZ by AutoDesSys
99% of the 3d illustrations you see on my blog were created in FormZ. Although I have extensive experience in more mainstream 3d tools such as Maya and 3ds Max, FormZ is still my go-to program for 3d rendering for one simple reason: simplicity. Other tools such as Maya can be horribly complex for simple 3d renderings, but FormZ's modeling and rendering tools are set up perfectly for the kind of work that I do. It's a very lightweight program with the power to create beautiful renderings in a fraction of the time that it would take me in Maya or 3ds Max.
Wacom Intous 5 drawing tablet
My career as a designer took a huge turn for the better after purchasing my first Wacom tablet in early 2006. To be honest, I didn't even like it at first because it was so hard to get used to. But I powered through the learning curve and I would be completely lost without my current Intuous 5 – especially when it comes to creating airliner art and car illustrations. There's no way I could do either of those things without the precision and control I can achieve by using a drawing tablet, and the customizable buttons on the Intuous speed up my workflow by allowing me to eliminate the keyboard completely as I'm drawing (which is a huge plus).
Stock photo websites
It was at Dreamstime where I launched the Norebbo brand back in 2006, and I had the most success selling my 3d illustrations there than anywhere else. I found their management and support team to be the most fair of all the major online stock photo agencies, and for that reason alone, it's the only place where I buy stock photos today. It's also the only place I can confidently recommend to other artists and photographers who are looking to sell their own work.


text:
Author has written 6 stories for Labyrinth, and One Life To Live.
You want a bio of 'lil old me:)
Well where to begin:
What can I say? I stumbled into this site and fell in love with it. I love to read all kinds of fan fiction, but am getting more and more into writing them.
UPDATE 12/3/08: I am working my through finals, and will (hopefully, keep your fingers crossed) have about a month to get some of my works figured out. It is my goa. to get this stuff back on track, as well as some new ideas and works from fandoms like SVU and such...