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Fluorescence histochemical evidence for axonal growth and secretion from transplanted adrenal medullary tissue
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Small pieces of rat adrenal medulla were homologously transplanted to the anterior chamber of the eye. The eyes were adrenergically denervated. Transplants became attached to and vascularized by the iris of the host eye. Transplants and irides were examined at various times postoperatively with the histochemical fluorescence method of Falck and Hillarp.
It was shown that the adrenal medullary transplants were able to produce catecholamine-containing nerves that partly reinnervated the denervated host iris. The nerves derived at least partly from groups of highly fluorescent cells, similar to the adrenaline and/or noradrenaline cells of the normal adrenal medulla. The cells were thus not similar to sympathetic adrenergic nerve cells.
Intravasal secretion of fluorescent material was observed in one case, indicating that the transplanted medullary tissue was also able to fullfill its normal endocrinological role of releasing hormones to the blood stream.
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With Orlando Pirates' 80th anniversary around the corner, Muhsin Ertugral has admitted he has felt some sort of pressure to deliver this season.
Ertugral missed out on an opportunity to ease the burden on his shoulders when his side fell at the first hurdle of the MTN8 at the beginning of this campaign.
Pirates were knocked out by eventual winners Bidvest Wits, following a 2-1 defeat at the Clever Boys' home ground.
The Telkom Knockout, which kicks off tonight in a clash between Cape Town City and Bloemfontein Celtic in the Mother City, will serve as a perfect opportunity for Ertugral and his charges to make up for their early exit they suffered in the MTN8.
Pirates host Lamontville Golden Arrows at Orlando Stadium this Sunday (kick-off 3pm), a side they beat 3-1 in their first league match.
But Ertugral said their previous result against Abafana Be'sthende won't affect this one.
"With Pirates, pressure is always there. You can't avoid it," Ertugral said. "If my memory serves me well, this is my eighth big club I've coached in my career. I think I can handle it. You know how these things work, sometimes they work out and sometimes they don't. With me, I always give it my utmost best to make sure they always do. But we'll have to wait and see.
Ertugral believes that in Arrows they face a 'very good side'.
"It is no fluke that they are where they are now on the PSL standings (second). We'll give them the respect they deserve while we push for the required result to go through,"" he said of the club he previously coached.
Having lamented the heavy toll representing their countries has taken on some of his players, the fiery Turkish coach plans to give a few of them a break. One of those players will be Abbubaker Mobara, pictured, who hasn't had much of a breather following his return from the Rio Olympics and his recent Bafana Bafana call-up.
"We have to rest some of our players, like Mobara for instance," Ertugral said. "He's had a hectic schedule and we'll have to give him a break or otherwise he'll get injured like other players. Thabiso Kutumela got injured in a one on one situation with Ntsikelelo Nyauza (yesterday morning at training). (Tendai) Ndoro couldn't train with us and had to go for a medical check-up. Edwin Gyimah is still recovering from his tendon injury. Gladwin Shitolo is making good progress and hopefully he'll be back after the Kaizer Chiefs game. Nkosinathi Mthiyane has resumed training and hopefully he'll be ready in the next two weeks."
While his dressing-room resembles a hospital, the Pirates squad is big enough for Ertugral to come up with a decent team to go past Arrows.
Meanwhile, Ertugral said he was pleased with the progress Tercious Malepe was making in training, following his arrival at the club from Moroka Swallows this season.
"He's been knocking on the door for quite some time now but it's not that easy for us to bring him in because we also have the responsibility of producing results."
The Star


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Question: Identify and explain the three global product strategies
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Answer to relevant QuestionsDescribe and explain the career path for tour operations?Below are many fascinating questions about European History in the 19th Century. Chose one of these questions, research your answer, and draft an 8-10 page paper. Attached with these questions is a bibliography of works that ...What is a dashboard? How does it help monitor performance?Consider the following three companies: - Gasco owns and operates a chain of gas stations in the northeast US.- Fuelco is a pre-revenue company that is attempting to develop new fuel-cell technology to replace the internal ...Your manager requires that you, as cashier, immediately enter each sale. Recently, lunch hour traffic has increased and the assistant manager asks you to avoid delays by taking customers' cash and making change without ...
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Gliffy is a very useful online application which is meant to make designing floor plans, diagrams and flowcharts as easy as possible. It's also possible to create technical drawings with the same application. It's been designed with the intention of making it easier to tell people what you want because you can show them a picture. Gliffy makes it easier to communicate and make decisions. Thousands of people have used Gliffy to create diagrams for a wide range of applications including industry and small business owners. Some multinational businesses are also using Gliffy. As this is a web based application it is platform independent meaning that it can be accessed on a Mac, pc or even in Linux. This is a huge plus in a world where windows isn't always on top.Show more screenshots »
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Phoebe Frances Schaul, daughter of Mr. and Mrs. Robert F. Schaul of Ringoes, formerly of the New Vernon section of Harding Township, was married on Monday, Feb. 26, 2001 ("Lundi Gras") to Todd Nathan Thriffiley, son of Mr. and Mrs. James C. Thriffiley III of Bay St. Louis, Miss.
The Rev. Michael Tracey performed the candlelight ceremony at Our Lady of the Gulf Roman Catholic Church in Bay St. Louis.
Amanda J. Schaul of Isles of Capri, Fla., the bride's sister, and Amanda
B. Quinlan of Bay St., Louis, formerly of Springfield, Mass., were maids of honor. Casey Peterson of Fairfield, Conn., cousin of the bride, was a junior bridesmaid.
Alyssa Cassard of Ocala, Fla., the bridegroom's cousin, was flower girl.
Air Force Major James C. Thriffiley IV of Gulfport, Miss., and John T. Thriffiley of Hattiesburg, Miss., were best men for their brother. Ushers were Victor DeBouchel of Arabi, La., Alexander DeFraites, Erin English, and Alan Thriffiley, all of Chalmette, La., and the bridegroom's cousins, and Bryant W. Griffin IV of Rochester, N.Y., cousin of the bride.
Andrew Thriffiley of Chalmette, the bridegroom's godson, served as ring bearer.
The bride is a graduate of The MacDuffie School, Springfield, Mass., and Syracuse University College of Nursing, Syracuse, N.Y. She is a First Lieutenant in the Air Force, attached to the 81st Training Wing, Keesler Air Force Base in Biloxi, Miss. Her father is the municipal court judge in Harding Township and the borough of Bernardsville.
The bridegroom is a graduate of St. Stanislaus Prep., Bay St. Louis, Millsaps College, Jackson, Miss., and Mississippi College of Law, Jackson. He is an attorney with offices in Gulfport and Bay St. Louis. His father is a member of the faculty of St. Stanislaus Prep.
Following a wedding trip to Jamaica, the couple is at home in Bay St. Louis.


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April 22nd, 2012
Tatenen, who unseated rider at the Canal Turn in the John Smith's Grand National, could bid for compensation in the Bet365 Gold Cup at Sandown.
January 30th, 2012
Tatenen could return to Ascot and step up to Grade One level in the middle of next month following his victory at the track last month.
January 24th, 2012
Richard Rowe is eyeing up a crack at the John Smith's Grand National following his battling victory at Ascot on Saturday.
December 26th, 2008
Follow The Plan beat Arkle favourite in a dour battle at Leopardstown.


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Don't forget to submit a picture of your kids for the Super Siblings Photo Contest! The submission deadline is tomorrow, Wednesday, May 5, 2010 at 11:59pm CST.
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Submit your original photo of your child(ren) (no more than 250 KB allowed) to email@example.com by 11:59pm CST on Wednesday, May 5, 2010. Please include this information with photo submission:
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Revolution in Britain
1915 - Vladimir Lenin a 19 year old boy in the Russian army deserts after killing three of his comrades in a feud during a battle in the First World War. He sneaks onboard a ship bound for the English east coast, he arrives and three months later gets involved with public speeches and attracts the attention of young men and women.
1916 - At just 20 years of age Lenin has created his own party, the Soviet Socialists of Britain (SSB). Lenin believes that this country is more powerful than any other nation but it is being weakened by corrupted politcans, old age generals and weak citizens. He told the people of the British Empire to stand up to them for what's right not wrong for what we want not them. Young men and women were beginnig to see what he saw.
1917 - April 22nd 1917 millions of workers stormed the capital of Britain with Lenin leading them. Buckingham Palace was attacked by hundreds of people and so, too, was the parliament building. The king and queen were executed and leading parliament members were removed. Because Lenin was now in command of the country he told the generals of the British army to bring our soldiers home and one by one British divisions were pulled off the western front.


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End-of-Life Plastic recycling
Sustainability as a Service™
Recycling Technologies provides a solution to chemically recycle End-of-Life Plastic back into a valuable low sulphur hydrocarbon we call Plaxx®.
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How can this be saved into an existing file in Box?Asked by crossland on February 23, 2017 at 02:37 PM
How can this be saved into an existing file in Box?
This is a re-post of a comment on How to Integrate JotForm with Box
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The Master Flow 3-1/4 in. x 10 in. Short Way 90° Rectangular Elbow helps create right angle turns in rectangular stack duct runs. This elbow is made of zinc-coated, 30-Gauge galvanized steel. You can install this elbow with sheet metal screws (not included). It is recommended to seal seams with code approved mastic, sealant or duct tape.
- Made of zinc-coated galvanized steel
- 30-Gauge, galvanized steel construction
- Helps create a right angle turn in rectangular stack duct runs
- Seal seams with code approved mastic, sealant or duct tape
- Install with sheet metal screws (not included)
- Recommended to insulate ductwork for greater system efficiency
- Features a minimum temperature rating of -100°F and a maximum temperature rating of 390°F


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ELEVEN more Sri Lankans have decided to return home instead of staying in offshore processing - but the government will have to make room for a new boat arrival carrying more than four times that many people.
The news came as refugee groups yesterday claimed 300 of the 380 asylum seekers on Nauru were prepared to die in a hunger protest that forced 35 people to seek medical aid after the first four days.
But the immigration department insisted the figures were exaggerated because the food being consumed was consistent with only about 100 people protesting and that less than a dozen had required medical assistance.
A department spokesman said the decision by the 11 asylum seekers to return home took the total of Sri Lankans to do so this year to 126.
Five left Perth on Friday while the other six departed Christmas Island on Saturday.
"Regular transfers to Nauru and more Sri Lankans returning home is further proof that there is no advantage engaging with people smugglers," the spokesman said.
But the decision emerged as Customs and Border Protection confirmed the latest boat - the 103rd since Labor's backflip and return to offshore processing - had been intercepted on Saturday.
Home Affairs Minister Jason Clare said the boat carrying 49 people was discovered northwest of Cocos Keeling Islands.
"People arriving by boat without a visa after August 13, 2012, run the risk of transfer to a regional processing country," he said.
Opposition customs spokesman Michael Keenan said Labor had lost all credibility on border protection since undoing the Howard government's procedures.
"They gave the kiss of life to a people smuggling trade that had been defeated and they have provided incentives for these criminals to continue with every failed policy," Mr Keenan said.
Refugee Action Coalition spokesman Ian Rintoul said the asylum seekers were demanding the closure of the centre, a trip to Australia and the processing of their cases.
He said one Iranian man had not eaten for 24 days.
"It is going to be a long hunger strike. Some people are saying they are willing to strike to the death," Mr Rintoul said.
The department said people in immigration detention could request their removal from Australia at any point.
"Those who choose to depart voluntarily can be provided with individual reintegration support to assist with their sustainable return, through the International Organisation for Migration," the spokesman said.
Originally published as 11 leave, more boats land


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Deleted Admin & Includes folder in ftp for WP3 upgrade
I'm in process of upgrading from 2.9.2 to WP3 Beta2. I misunderstood the instructions and deleted the sites wp-admin & wp-includes folders in the ftp on the server. Just the content left but i started deleting the content folder first and realized half way through (was using ftp that time!), closed the ftp program half way through.. thought it might have cancelled everything. Then went in cPanel everything seemed to be still there but then disappeared on refresh after a while couldn't download any of it with my trys.
I have a full up to date back up of the mySQL database . Ive made a mess can i contact the host and retrieve the lost folders? What else could i do to get out of this mess? site won't load. I've been able to save all the plugins and the config.php file. But all my uploads and theme i can not find. But could get iNove easy enough.
- The topic 'Deleted Admin & Includes folder in ftp for WP3 upgrade' is closed to new replies.


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CLIFTON – John J. Teryek, Jr., 77, husband of Ena M. (Myers) Teryek, died June 7, 2014 at his home with his family at his side. He was born Sept. 6, 1936 in Bound Brook, NJ, the son of John J. Teryek, Sr and Anna (Consolvo) Teryek. In addition to his wife of 56 years of Clifton, John is survived by three children, Wade Teryek of Clifton, Lynn Shanley and her husband, Thomas of Clifton and JoEna Donovan and her husband, Bob of Bedford, NH. John requested that services be private. Arrangements by Kiley & Foley Funeral Service, 69 State St., Brewer.
John J. Teryek, Jr.
Posted June 09, 2014, at 6:10 p.m.


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The kinetics and metabolism in various organs of three bioactive products of progastrin, the small sulfated and nonsulfated gastrin-6 and the large nonsulfated gastrin-52, were examined during intravenous administration in anesthetized pigs. The kidney, hindlimb, liver, head, and gut eliminated the hexapeptides efficiently, with a fractional extraction ranging from 0.50 to 0.28 (P < 0.001–0.05). No metabolism was recorded in the lungs, and sulfation was without influence on the extraction of gastrin-6. Gastrin-52 was eliminated only in the kidney and the head, with a fractional extraction between 0.23 and 0.11 (P < 0.01–0.05). The half-life of sulfated and nonsulfated gastrin-6 was 1.5 ± 0.4 and 1.4 ± 0.3 min, the metabolic clearance rate (MCR) was 80.8 ± 7.6 and 116.0 ± 13.5 ml · kg−1 · min−1(P < 0.05), and the apparent volume of distribution (Vdss) was 199.3 ± 70.1 and 231.4 ± 37.3 ml/kg, respectively. The decay of gastrin-52 in plasma was biexponential. The half-lives of this biexponential after a bolus injection were 3.9 ± 0.5 (T 1/2α) and 25.7 ± 1.4 (T 1/2β) min, and the MCR and Vdsswere 4.2 ± 0.4 ml · kg−1 · min−1 and 116.2 ± 16.2 ml/kg1. We conclude that there is a differential elimination of progastrin products in splanchnic and nonsplanchnic tissue, which depends on the chain length of the peptides. Sulfation of gastrin-6 had no influence on the organ-specific extraction but reduced the MCR. Our results are in keeping with previous studies of nonsulfated gastrin-17, which is extracted in the kidney, head, limb, and gut but not in the liver.
- gastrointestinal hormones
gastrin is an important gastrointestinal hormone that regulates gastric acid secretion and the growth of gastric mucosal cells (for review, see Ref.6). Gastrin is synthesized mainly in antroduodenal G cells. The cellular synthesis is a complex process, during which progastrin is processed to a number of bioactive gastrins of different length (Fig.1). The bioactive gastrins all share the same α-amidated COOH terminus (Tyr-Gly-Trp-Met-Asp-Phe-NH2), of which the tetrapeptide amide constitutes the active site (19), and the length of the NH2 terminal extensions governs the metabolism and clearance of circulating gastrins. Today gastrin-71, -34, -17, -14, and -6 have been structurally identified as antral progastrin products, all in Tyr-sulfated and nonsulfated forms, and gastrin-52 has been identified by immunochemical methods (9-12, 27,29). In antral venous blood, gastrin-17 accounts for >80% of postprandially released α-amidated gastrin. The remainder is mainly gastrin-34 and -6, which are released in approximately equal amounts, and gastrin-71 and -52 each account for <1% (13,27).
The metabolism and clearance from circulation of gastrin-34, -17, and -14 have been well studied in humans and other mammals (2, 4, 24,31, 32, 34-36). Moreover, the metabolism of glycine-extended gastrin-17 has been thoroughly investigated (3,24). Glycine-extended gastrins are the immediate precursors of the carboxyamidated active gastrins, and they are also released from G cells into circulation (13, 14). Under normal conditions, gastrin-17 and -34 are the predominant plasma gastrins in most mammals (25). However, as the molecular forms in plasma change toward longer or smaller, less processed forms in diseases with increased gastrin synthesis (16), it is relevant to examine the metabolism and kinetics of all circulating gastrin forms.
Gastrin-71, -52, and -6 are the most recently identified gastrins (12, 27, 29). So far, gastrin-71 has not been synthesized or purified in amounts sufficient for metabolic studies. In this study we have, therefore, examined only gastrin-52 and -6. The study was undertaken in anesthetized pigs during separate administration of each peptide, and the metabolic parameters were compared with those of gastrin-17 (24).
Sulfated gastrin-6 (mol wt 897 Da), nonsulfated gastrin-6 (mol wt 817 Da), and nonsulfated gastrin-52 (mol wt 6,018 Da) were custom synthesized by Cambridge Research Biochemicals (Zeneca, Cheshire, UK). Peptide content and purity were controlled in our laboratory by amino acid analysis (LKB amino acid analyzer with fluorescence detection; LKB Biochrom, Cambridge, UK) and reverse-phase HPLC (model 10843; Hewlett-Packard, Palo Alto, CA). Before infusion, the peptides were diluted in isotonic saline with 1 g/l of human albumin.
Animal Preparations
The investigations were carried out in four groups of eight pigs (Danish Landrace-Yorkshire breed, 30–40 kg) under general anesthesia. The animals were fasted overnight but had free access to water. The study conformed with the legal requirements for animal experiments.
Anesthesia was introduced with ketamine (8 mg/kg Ketalar; Warner-Lambert/Parke Davis, Morris Plains, NJ) and a gas mixture of 1% halothane (Halocarbon Laboratories) and nitrous oxide in oxygen (2:1). After intubation, halothane was withdrawn and anesthesia was continued with repeated doses of pentobarbital sodium (2.5 mg/kg Mebumal; Nycomed DAK, Copenhagen, Denmark) and pancuronium (0.1 mg/kg Pavulon; Organon, Oss, The Netherlands) as a supplement to nitrous oxide under intermittent positive-pressure ventilation. Isotonic saline was infused at 10 ml · kg−1 · h−1 in all pigs during the whole experiment. In addition, donor blood from siblings was constantly infused with a pump in volumes equal to that removed during blood sampling. Arterial blood pressure and electrocardiograms were continuously monitored, and cardiac output was measured regularly with a Swan-Ganz thermodilution catheter (Swan-Ganz pediatric 5F; Baxter Health Care, Santa Ana, CA). Carbon dioxide tension, oxygen tension and saturation, pH, and standard bicarbonate were measured in all vascular beds used for blood sampling (ABL 2; Radiometer, Copenhagen, Denmark).
Catheters for blood sampling were placed as follows. Polyethylene catheters were positioned in the thoracic aorta via the left carotid artery and cephalically in the left internal jugular vein. Via the external jugular veins, two angiography catheters were introduced into a major hepatic vein and the left renal vein. Blood from a peripheral lung artery was drawn from the Swan-Ganz catheter. The positions of all catheters were controlled fluoroscopically. Neither the hepatic nor the pulmonary catheters were wedged, to avoid mixing with portal and pulmonary venous blood when samples were drawn. After a midline laparotomy, a catheter was introduced into the entrance of the portal vein via the splenic vein and another catheter was positioned in one of the major tributaries of the mesenteric vein draining the small intestine. Blood from the femoral vein was drawn from an inserted catheter after exposure of the vessels in the groin. Peptides and indicator substance were infused into catheters with their tips placed in the right atria. After completion of surgery, a stabilization period of 1 h was allowed before start of the experiments.
Blood flow in the renal and femoral artery and the portal vein was measured with an electromagnetic flowmeter (Nycotron, Oslo, Norway), and pulmonary flow was regarded as equivalent to the cardiac output. Blood flow was converted to plasma flow from the hematocrit. Hepatic plasma flow was measured by continuous infusion of indocyanine green (Cardiogreen; Becton Dickinson, Cockeysville, MD) at 0.130 μmol/min. After a calibration period of 90 min, simultaneous samples from the aorta and the hepatic vein were drawn at 10-min intervals. The concentration of indocyanine in plasma was measured spectrophotometrically, and hepatic plasma flow was calculated according to Fick's principle as where Q is dose rate, BW is body weight, Ca and Cv are plasma concentrations in the aorta and the hepatic vein, and dCa/dt and dCv/dt are the linear regressions of the arterial and venous concentrations with time (t).
Elimination of sulfated and nonsulfated gastrin-6.
The elimination of the peptides was measured from the concentration gradient across the vascular beds during separate infusion of sulfated gastrin-6 (460 pmol · kg−1 · h−1) and nonsulfated gastrin-6 (600 pmol · kg−1 · h−1) in two groups of eight pigs. The infusion rates were determined from previous pilot studies. Arterial samples were taken from the aorta every 15 min during infusion. After 90 min, venous samples were drawn every 15 min for 1 h from a lung artery and the femoral, renal, portal, hepatic, internal jugular, and cranial mesenteric veins. The cranial mesenteric vein is almost equivalent to the superior mesenteric vein in humans and drains the major part of the blood from the small intestine and the first part of the large intestine. When the infusion of the peptides was terminated after 170 min, aortic blood was sampled at regular intervals for 90 min to determine the half-life of the peptides.
Elimination of gastrin-52.
Gastrin-52 was infused at 12 pmol · kg−1 · h−1 in eight pigs; the experimental design was otherwise similar to the study of gastrin-6. Because the disappearance of gastrin-52 from plasma follows a two-compartment model, the kinetic parameters were also calculated after a bolus injection (5 pmol · kg−1 · h−1) in another group of eight pigs. Arterial blood samples were drawn at regular intervals until 90 min from the time of the injected bolus.
In vitro metabolism and recovery of gastrin-6 and -52.
The metabolism of peptides in plasma was evaluated by separate incubation of sulfated and nonsulfated gastrin-6 as well as gastrin-52 in porcine plasma at room temperature for 0, 1, 2, 4, 8, and 24 h. After incubation, the samples were immediately frozen in liquid nitrogen and stored at −20°C until analysis.
Laboratory Analyses
Blood samples were collected in ice-chilled tubes containing 50 IU heparin and 250 μl aprotinin (5,000 KIU) and placed on ice. After centrifugation, plasma was stored at −20°C until radioimmunoanalysis. All radioimmunoassay measurements were performed with previously described assays developed in our laboratory. All samples of each experiment were performed in a single assay.
Antiserum 2604 measures total concentration of carboxyamidated gastrins larger than the hexapeptides (30). The antiserum was raised against the α-amidated 2–17 fragment of human gastrin-17 and is directed against the COOH terminal part of the peptide. The antiserum binds gastrin-71, -52, -34, and -17 with equimolar potency; the reactivity with CCK is <0.5%. Synthetic human gastrin-17 was used as standard, and monoiodinated 125I-gastrin-17 was used as a tracer (26). The accuracy of the assay was evaluated by the recovery of known amounts of peptide added to plasma. The precision (intra-assay variation) was expressed by the coefficient of variation of repeated measurements of peptide in plasma at three different concentrations. The accuracy ranged from 84 to 102%, and the precision was 5%.
Sulfated and nonsulfated gastrin-6 were measured with antiserum 2609 after extraction of the peptides from plasma. Antiserum 2609 was also raised against the 2–17 fragment of human nonsulfated gastrin-17 (28). In contrast to antiserum 2604, which requires an epitope of seven residues or more for binding, antiserum 2609 requires only the COOH terminal tetrapeptide amide sequence for binding. The reactivity is 63% with gastrin-34 and 20% with CCK-8. One milliliter of plasma was extracted with 2 ml of 96% ethanol, and the supernatant was evaporated under a constant air flow. The dry extracts were then reconstituted in assay buffer. Sulfated and nonsulfated gastrin-6 were used as standards, and monoiodinated 125I-gastrin-17 was used as a tracer. Measurements of sulfated gastrin-6 had an accuracy of 91–98% and a precision of 1–8%. For nonsulfated gastrin-6, the accuracy ranged from 86 to 95% and the precision ranged from 4 to 6%.
Gastrin-52 was measured using antiserum 88235, which was raised against fragment 20–33 of human progastrin that corresponds to the NH2 terminus of gastrin-52 (29). The antiserum is specific for the sequence 20–25 of progastrin. The antiserum does not bind gastrin-34, -17, or smaller carboxyamidated gastrins, nor does it react with CCK. Synthetic human gastrin-52 was used as standard, and monoiodinated 125I-gastrin-52 was used as a tracer (26). The accuracy of measurements ranged from 80 to 94%, and the precision was 20%.
The elution profile of each peptide was determined by means of gel chromatography. Plasma from eight pigs of each group was pooled, and 1-ml samples were applied to Sephadex G-50 superfine columns (10 × 1,000 mm and 12 × 2,000 mm; Pharmacia, Uppsala, Sweden). The short columns were eluted with 0.125 M NH4HCO3(pH 8.2) with a flow rate of 4 ml/h and calibrated with sulfated and nonsulfated gastrin-6. The long columns were eluted like the short columns but with a flow rate of 3 ml/h and calibrated with gastrin-52. Void volume and total volume were determined by elution of125I-albumin and 22NaCl. Fractions of 1 ml were obtained and analyzed with antisera 2604, 2609, and 88235. The elution position (K d) was calculated as where Ve is the elution volume of the peptides and Vo and Vt are elution volumes of125I-albumin and 22NaCl, respectively.
The fractional extraction of the peptides in the vascular beds was calculated as where Ci and Co are inflow and outflow concentrations in plasma. The fractional extraction in the liver was grossly estimated from the difference between the inflow concentrations in arterial (Ca) and portal (Cp) plasma and the outflow concentration in hepatic venous plasma (Ch) and the respective flows (F) Arterial flow was estimated by subtraction of portal flow from total liver flow. Clearance of the peptides at the metabolic sites was calculated by multiplying extraction ratio with plasma flow.
The kinetics of sulfated and nonsulfated gastrin-6 were calculated according to a one-compartment open model where Co and Ct are plasma concentrations at zero time and t. The half-life was determined from the elimination in arterial plasma after termination of the infusion. Plasma concentrations were plotted on semilogarithmic graph paper after subtraction of basal values. Linear regression of the logarithm of plasma concentration vs. time was computed to yield the slope (ke ), from which the half-life was calculated by dividing into 0.693. The metabolic clearance rate (MCR), which is total body clearance, was calculated from dose rate divided by the plateau increment of peptide in plasma. The apparent volume of distribution (Vd) was determined by dividing MCR withke of the regression line for disappearance.
The kinetics of gastrin-52 were analyzed according to a two-compartment open model where A and B are the zero intercepts with the ordinate of the individual exponential terms and α and β are the slopes of the curves. When a substance displays two- or multicompartment kinetics, prolonged infusion may load the deep compartment with the substance, so that the postinfusional plasma curve shows little distributional activity and is of limited analytic value. Therefore, the parameters were calculated from postinfusional data and from the decay in plasma after a bolus injection. When model parameters were calculated from postinfusional data, the values of Aand B, which would have followed a single intravenous dose of the same magnitude, were calculated from the zero interceptsR and S at the start of the postinfusional period where T is the period of infusion (18). Area under the curve (AUC) was determined as During constant-rate infusion, the MCR was calculated the same way as for gastrin-6. After bolus injection, MCR was calculated from injected dose divided by AUC. The apparent volume of distribution at steady state (Vdss) was calculated as the sum of the central and peripheral compartment volumes. The rate constants of the model and the volumes of the central and peripheral compartments (V1 and V2) were calculated as where k 12 and k 21are the first-order rate constants of distribution between the central and peripheral compartment and k 10 is the sum of the simultaneous processes of metabolism and excretion.
All results are expressed as means ± SE. Statistical analysis was performed by Wilcoxon's test for paired samples and the Mann-Whitney test for unpaired samples. P values <0.05 were considered significant.
Elimination of Sulfated and Nonsulfated Gastrin-6
The concentrations of the peptides during the studies are shown in Fig. 2. The corresponding dose rates of sulfated and nonsulfated gastrin-6 estimated from the concentrations in the infusion lines were 462.0 ± 20.4 and 597.9 ± 53.5 pmol · kg−1 · h−1, respectively.
Extraction of sulfated gastrin-6 was recorded over the kidney (P < 0.01), liver (P < 0.01), gut (P < 0.01), hindlimb (P < 0.01), and head (P < 0.01), whereas pulmonary extraction was not significant (Fig. 3; Table1). Extraction of nonsulfated gastrin-6 was observed over the kidney (P < 0.01), liver (P < 0.05), gut (P < 0.01), hindlimb (P < 0.01), and head (P < 0.01) but not over the lungs (Fig. 4; Table 1). The fractional extraction of sulfated and nonsulfated gastrin-6 was not significantly different.
The kinetics of sulfated and nonsulfated gastrin-6 followed a one-compartment open model (Fig. 5). The MCR, half-life, and Vd of sulfated gastrin-6 were 80.8 ± 7.6 ml · kg−1 · h−1, 1.5 ± 0.4 min, and 199.3 ± 70.1 ml/kg, respectively. For nonsulfated gastrin-6, the values amounted to 116.0 ± 13.5 ml · kg−1 · h−1(P < 0.05), 1.4 ± 0.3 min (not significant), and 231.4 ± 37.3 ml/kg (not significant), respectively. The hemodynamic values measured during the experiments and the calculated clearance of the peptides at the metabolic sites are presented in Tables 2 and3.
Elimination of Gastrin-52
Plasma concentrations of gastrin-52 during the study are shown in Fig. 6. The corresponding dose rate of the peptides was 11.7 ± 1.7 pmol · kg−1 · h−1. The fractional extraction of gastrin-52 was significant in kidney (P < 0.01) and head (P < 0.05) but nonsignificant in the liver, gut, hindlimb, and lung (Fig.7; Table 1). The extraction in kidney and head was lower than of sulfated and nonsulfated gastrin-6 (P < 0.01 and 0.05, respectively).
The kinetics of gastrin-52 followed a two-compartment open model (Fig.8). When the pharmacokinetic parameters were calculated from postinfusional data, the half-lives of the biexponential, T 1/2α andT 1/2β, were 4.3 ± 0.8 and 29.3 ± 3.1 min, and the MCR and Vdss were 3.1 ± 0.2 ml · kg−1 · min−1 and 98.5 ± 9.4 ml/kg, respectively. When the pharmacokinetics were calculated from plasma concentrations after a bolus injection (5.3 ± 0.2 pmol/kg), the half-lives were 3.9 ± 0.5 (T 1/2α) and 25.7 ± 1.4 min (T 1/2β), and MCR and Vdssamounted to 4.2 ± 0.4 ml · kg−1 · min−1and 116.2 ± 16.2 ml/kg, respectively. The kinetics of the two peptides were not significantly different. The respective fractions of elimination during the β-phase, [(B/β)/AUC], were 0.75 and 0.71, which implies that the major part of the elimination took place during the β-phase. Hemodynamic values measured during the investigations and the calculated clearance of the peptides at the metabolic sites are shown in Tables 1 and 2.
In Vitro Degradation of Progastrin Products
The recovery of sulfated and nonsulfated gastrin-6 during the first 8 h of incubation in plasma ranged from 90 to 97%. Gastrin-52 was stable for 4 h when immunoreactivity was measured with the NH2 antiserum. After 8 and 24 h, the immunoreactivity in plasma had decreased to 85 and 68%, respectively. There was no reduction in COOH terminal immunoreactivity during 24 h of incubation.
Gel chromatography of arterial plasma during infusion of sulfated and nonsulfated gastrin-6 revealed a peak at K dof 1.26 and 1.12, which corresponds to the elution positions of the standard calibration peptides (Fig. 9). Chromatography of gastrin-52 in arterial plasma revealed one major peak at a K d of 0.29, which is the elution position of the intact peptide. This peak was visible with the NH2terminal (antiserum 88235) and the COOH terminal antibody (antiserum 2604) (Fig. 9). Smaller NH2 or COOH terminal fragments were measured neither in arterial nor in venous plasma from the metabolically active sites in head and kidney.
The present study revealed a differential elimination of bioactive gastrins in organs as well as in nonsplanchnic tissue. Previous studies have shown that the major biosynthetic endproduct of progastrin, gastrin-17, is eliminated at multiple sites in the body (4, 24,32). These observations led to the conclusion that gastrin is cleared in all major vascular beds. However, the present results suggest that this conclusion needs modification, since we found that the metabolic sites for bioactive gastrin varied according to the molecular size of the peptides. A differential metabolism of gastrin as well as other gastrointestinal peptides has so far only been recorded in the liver (7, 8, 34), but the present study also demonstrated a differential extraction in the gut and hindlimb. Only the head and kidneys were capable of eliminating gastrin peptides independent of their size but with a higher fractional extraction for small peptides.
An arteriovenous concentration gradient has been measured in the heads of different animals during infusion of gastrin-17 (4, 20,32). In pigs, blood from the brain and the musculoskeletal part of the head have a common drainage into the internal jugular vein. Although selective venous samples from the brain were not obtained in this study, two observations are in favor of a cerebral gastrin metabolism. One is an abundant expression of the gastrin/CCKB receptor in the brain (17). The other is the selective extraction of the hexapeptides and gastrin-52 in the musculoskeletal system (the hindlimb), whereas gastrin-6 and -52 were both extracted in the head.
The kidneys have been regarded as important sites of extraction of circulating peptides. The glomerular filtration of gastrin is influenced by the Donnan effect, with an enhanced filtration of negatively charged peptides (21, 23, 33). After glomerular filtration, the peptides undergo an almost complete tubular absorption and metabolism, since excretion of intact peptides in urine accounts for <1% of the filtered amount. Since most gastrins, including gastrin-34, -17, and -6, are eliminated at several sites in the body with an integrated clearance exceeding that of the kidneys, renal contribution to the MCR seems only to be of major importance for large gastrins like gastrin-52 and, probably, gastrin-71. However, hypergastrinemia found in some patients with renal failure is only partially explained by low renal clearance of gastrin. An increased release of gastrin caused by hypo- or achlorhydria and hypercalcemia in combination with a decreased metabolism in other vascular beds are more likely explanations. Moreover, hemodialysis may contribute to the complexity of gastrin physiology in these patients (20).
The role of the liver in the metabolism of gastrointestinal peptides has been debated because of the number of conflicting results. Animal experiments in pig, dog, and rat with infusion of gastrin and CCK fragments of different chain length have shown that peptides with eight or fewer amino acid residues are subject to hepatic extraction, whereas larger peptides are increasingly resistant to elimination in the liver (5, 7, 8, 34). The present results confirm these observations, since only the hexapeptides were cleared in the liver. Earlier investigations by us (24) failed to demonstrate elimination of human gastrin-17 in the porcine liver, but hepatic elimination of postprandially released gastrin-17 has been recorded in pigs in two independent studies (3, 22). Since human gastrin-17 has been used in most animal studies of gastrin, the conflicting results could result from the species difference of the peptide. Despite the close structural similarity of gastrin-17 among mammalian species, only gastrin-6 is identical in animals and man, whereas larger gastrins differ with increasing chain length. Studies of the CCK octapeptide, which bears a close resemblance to gastrin-6, have shown that hepatic extraction is sensitive to even minor modifications of the molecule (8).
Besides the liver, both the gut and hindlimb displayed a differential elimination of gastrin with extraction of the hexapeptides, whereas gastrin-52 passed unhindered. Since clearance of gastrin-17 has also been recorded in the hindlimb of pigs (24), the musculoskeletal system, therefore, represents the major metabolic site of short- and medium-sized gastrin peptides.
The lungs were the only site without a significant gastrin elimination, and earlier studies in pigs also failed to demonstrate pulmonary extraction of gastrin-17. However, a small pulmonary extraction of gastrin-17 of ∼10% has been measured in sheep (4). This means that the lungs in sheep are responsible for the metabolism of as much as 50% of circulating gastrin and, therefore, represent the major metabolic organ in gastrin metabolism. However, even small variations in the measurement of venous and arterial concentrations may lead to a false high clearance due to the high pulmonary blood flow.
Degradation of the peptides in vitro was slow, since gastrin-52 and -6 retained their immunoreactivity for several hours after incubation in plasma. Metabolic products of gastrin-52 in plasma were recorded neither in vitro nor in vivo, probably due to low concentrations of the intact peptide.
Derivatization of gastrin peptides increases their resistance to metabolism. Thus amidation of the COOH terminal carboxy group protects against carboxypeptidases. This was evident from incubation of gastrin-52 in plasma, which resulted in a decreased NH2terminal immunoreactivity, whereas the COOH immunoreactivity was retained after 24 h. Also, sulfation of gastrin enhances resistance to metabolism, but this may only apply to small peptides. In humans, the MCRs of sulfated and nonsulfated gastrin-17 were found to be approximately the same (1), whereas MCR of sulfated hexagastrin in cat was nearly sixfold higher than the nonsulfated form (15). In the present study, sulfated gastrin-6 had a 30% lower MCR than the nonsulfated form. Apart from derivatizations, the MCR also depends on the chain length of the peptides. Thus the higher MCR of gastrin-6 compared with gastrin-52 is in accordance with the general experience that clearance of peptides varies inversely with chain length. There was a good agreement between the MCR of gastrin-52 and the integrated organ clearance, but a considerable difference was recorded for gastrin-6, also when an estimation for the clearance by the trunk was made. A similar discrepancy was present in metabolic studies of the octapeptide of CCK in pigs (5). A false high value of the MCR may result from either intravascular degradation or from sequestration of the small peptides at extravascular sites. This would also lead to a high Vd, which for sulfated and nonsulfated gastrin-6 was twice as high as Vd for gastrin-52 and -17 (24).
We conclude that the differential elimination of gastrin found in pigs is related to chain length of the peptide. A selective elimination was recorded in most vascular beds. Only the kidney and the brain displayed a nonselective extraction of gastrin.
The expert technical assistance of Inge Mortensen, Winna Stavnstrup, Letty Klarskov, Mette Olesen, and Sørn Haagen Nielsen is gratefully acknowledged.
The study was supported by grants from the Danish Hospital Foundation for Medical Research, Region of Copenhagen, the Faroe Islands, and Greenland, and the Danish Foundation for the Advancement of Medical Science.
Address for reprint requests and other correspondence: C. Palnaes Hansen, Dept. of Gastrointestinal Surgery C, Rigshospitalet, DK-2100 Copenhagen, Denmark
The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. §1734 solely to indicate this fact.
- Copyright © 2000 the American Physiological Society


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Money was one of man's greatest inventions. But we have become its slaves.
Money: the Unauthorised Biography unfolds a panoramic secret history and explains the truth about money: what it is, where it comes from, and how it works. Martin believes that the conventional wisdom that today's financial universe evolved from barter, is wrong. Not just wrong, but dangerous.
Money will radically rearrange your understanding of the world and shows how money can once again become the most powerful force for freedom we have ever known.
©2013 Failu Ltd (P)2013 W F Howes Ltd
"Combines breadth of scholarship with a wealth of practical experience in tackling the most elusive of economic subjects - the nature of money" (John Kay, author of The Truth About Markets)
'A most accessible and thrilling read. If you want to read just one book about money, this is it' HA-JOON CHANG, Economist
There are no reviews for this title yet.
"Informative and sometimes counter-intuitive"
Interesting and informative book about origins of money and how different the reality is from that promoted by conventional economics. Draws on history, ethnography, economics and sociology (and probably other disciplines) to introduce and explore key concepts around money, banking, debt and more, highlighting the importance of developing accepted means of exchanging assets and debts. Each chapter tackles a different aspect of analysis in its specific historical and social context.
Engaging and wide-ranging.
"A good window to financial and economic turbulence"
A good book that has given me an insight to what really is money and why there esteem to recurrent economic turbulence that seem to hit us every now and then. More importantly thought is the attempt at an explanation also of why we don't seem to see the turbulence coming. Felix Martin has done a stellar job but the level of presentation is not commensurate with intellectual magnitude.
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Thursday, April 2nd, 2009: 8 10 p.m.
Franklin Field
Philadelphia, PA
Clear, 58° F
Full pads
Practice Notes:
-The first practice in April was the warmest of the spring as temperatures in the Philadelphia area were in the 60's on Thursday. And it wasn't much cooler during the night practice.
- The team worked on some special teams Thursday night. A couple of the practice periods were spent on punting and punt returns. And after emphasizing the offensive side of point after attempts (PAT) on Tuesday night, the team worked on the defensive side of the PAT's. Last season, Penn blocked at least one extra-point, field goal and punt each. On the offensive side, kicker Andrew Samson was perfect on PAT's and no punts were blocked. Though the team's first field goal attempt of the season last year was blocked.
- Now into the eighth practice of the spring, there is increasingly more time spent on team drills as well as more 'live' drills where the players are allowed to tackle.
- On Tuesday, the squad spent 25 minutes on team drills in which they practiced situational down and yardage. Nearly the same amount of time was spent on the same format on Thursday. The situational scripting involves having the offense match up with the defense in specific down and distance situations. For example, on Tuesday, the offense ran numerous plays with the down and distance set at 1st and 10 and several more plays in 2nd and 8 or 2nd and 7 scenarios.
- On Thursday, the same situational down and yardage format was used with different scenarios. The team spent time in short yardage areas with a focus on goal line situations. They also worked on 1st and 10 again, then playing the result of the play.
- The Quakers have also made a small change in the spring schedule. In order to give the players a day off after an extended scrimmage in practice on Sunday, the team will have Monday night off. That practice moves to Tuesday, which was a rain date.
- It was the first official practice for Jon McLaughlin as the Quakers' offensive coordinator. However, there wasn't a change at practice as McLaughlin has largely taken on the responsibilities throughout the spring while the position was vacant. Matt Leon of KYW 1060 AM sat down with Coach McLaughlin earlier this week. The podcast of that interview should be available on the KYW website sometime on Friday.
Next Practice:
Friday, April 3rd; 8:00 PM 10:00 PM (full pads)


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- Orario d'apertura serale
- Galleria chiuse
Gallery closures
Please note that galleries may occasionally have to close at short notice.
Temporary gallery closures
Europe 1400–1800 (Room 46)
Closed 31 July 2017 until 15
November 2017
Collecting the world (Room 2)
The Waddesdon Bequest (Room 2a)
22 January 2018 until 24 January
Enlightenment (Room 1)
22 January 2018 until 2 February
Galleries with limited opening
Greek vases (Room 20a)
Open daily 10.00–11.00
Greek and Roman Architecture (Room 77)
Classical Inscriptions (Room 78)
Please enquire at the information desk for
opening times.
Long-term gallery closures
Greece: Cycladic Islands (Room 11)
Closed until further notice
China, South Asia and Southeast Asia (Room 33 - The Joseph E. Hotung Gallery)
India: Amaravati (Room 33a)
Chinese jade (Room 33b)
Closed 1 June 2016 – November 2017
Admonitions Scroll (Room 91a)
Closed 16th August 2017 until Summer
Objects normally on display within the gallery may be available
for study by appointment via the Department
of Asia Study Room. Please note that between the dates below
there will be no level access to Chinese Ceramics – Sir Percival
David Collection (Room 95) and Korea (Room 67), during which time
access will be via stairs only.


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Armaan Jain incites sheer envy in me. Firstly, because he's inherited his legendary grandfather Raj Kapoor's ruddy good looks. Secondly, just a year older than me, he is on the threshold of living his dreams. He gives you the vibe of a cool collegian. And when he laughs, his complexion turns robust much like cousin Ranbir Kapoor's. Incidentally, this is his first interview. Among the many firsts in his life, I can also claim some fame! "Dude, forgive me if I talk too much. I suffer from verbal diarrhoea. I have no clue what to answer, how to answer. Hope it's fun," he warns. Well he's inherited the entertainment gene from the Kapoors for sure. The general response to his musical debut Lekar Hum Deewana Dil (LHDD) is that he's a chip of the old block. Interestingly, the 1973 blockbuster Yaadon Ki Baarat had the song Lekar Hum deewana dil filmed on aunt Neetu Singh and Tariq.
Armaan admits he was under tremendous pressure before the film's release. "When you're coming from such an illustrious family (Arman is Raj Kapoor's younger daughter Reema Jain's son) comparisons are bound to happen," he confides adding, "But I see it as something positive. Intimidation makes you perform better." He continues, "My mother is a homemaker and my dad (Manoj Jain) is a businessman. I didn't grow up in a filmi atmosphere unlike my cousins (sisters Karisma and Kareena Kapoor and Ranbir). Watching a film on Sunday was a huge thing. I was more into sports, playing cricket at Azad Maidan or watching football. I never bragged about the fact that my maternal grandpa was
Raj Kapoor."
His classmates soon learnt about it. And when Kareena Kapoor played the sexy Pooh in Kabhi Khushi Kabhie Gham, it left him cornered. "My friends would say, 'Oh you're Kareena's cousin! She's so hot'. I'd feel embarrassed. They'd ask me to get her autograph." But little did he know that the acting bug would bite him soon. "When I was around 10, I suddenly enjoyed entertaining people. I'd do something stupid and make my classmates laugh. Somewhere I was inspired my grandfather's film Mera Naam Joker. I was an attention seeker. In that chaska, I did school theatre. I believed this was my calling. However, I went to England to study business. But after a year and a half, I realised I was wasting my time. I returned home." It required guts to break this news to his parents. "I feared they'd probably take it badly and ask me to complete my degree course. But they were supportive. My mother rued the fact that though we have RK Studio there's nothing happening there. She said that I'd have to do everything myself. Dad cautioned that I'd have to remain focussed. 'Do what you want as long as you give it your 100 per cent', he said. After that there was no looking back."
He began working with Karan Johar's Dharma Productions. "Karan gave me a chance to assist him in My Name Is Khan. It was a big opportunity. Later I assisted in Ek Main Aur Ekk Tu and Student Of The Year (SOTY)." Didn't he vie for a role in SOTY himself? "I went there purely to learn the craft. I fell in love with filmmaking in that atmosphere. I never asked them for a role. Had they liked me they'd have given me a chance. Anyway, Karan had already done a huge favour on me."
But LHDD was just round the corner. "I assisted in SOTY wearing a big nerdy chashma," says the handsome Arman who then out of the blue got a call from Arif Ali (younger brother of Imtiaz Ali). "I fell in love with the script of LHDD I was confident that if I trained myself for six months I'd crack it. We went through a round of auditions and I bagged the role." He believes no matter how famous your surname is, it's talent that takes you places. "Few know that there were a thousand girls who auditioned for Alia Bhatt's role in SOTY! Belonging to a film family might give you an opportunity. But you need to have the potential. If you're not good why will people invest crores in you in times when everyone's aiming for the 100 crore margin?"
He's glad that his cousins didn't present a rosy nor a gloomy picture to him. "They didn't want my expectations to be sky high. They didn't want to discourage me either.
I never took any tips from anyone. Mom told me 'Sab ka sun, apna kar'! At the end of the day it's only what you can do." He's irresistibly good-looking. Sure girls must be making a beeline for him. He rues, "I was fat five years ago. I was a 100 kilo kid! I was one big ball. My genetics are wrong." Well, along with talent he has also inherited the foodie gene he says. "The Kapoors are all about food. Jungli mutton, paya, beer…the works! The most important discussion is, 'What will we eat today?' and after that, 'What's the menu for tomorrow?'. So I have been only eating as a kid. I can't have eight packs. I was one big ball. I managed to lose some weight somehow. I wish there were girls by my side. But I have never dated anyone. I have always been single." Now, that's what we call acting!
Armaan Jain on grandfather Raj Kapoor
I learnt about my grandfather (Raj Kapoor) through his films. I thought Nanaji was a clown because I have seen Mera Naam Joker (1970) over 6000 times. I wanted to be Raju, the joker too. So I used to do all kinds of stupidities to make people laugh. I even loved Nanaji in Awara (1951) and Shree 420 (1955). The innocent man act touched my heart.


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Georgina Ansell Photographer
leonnie BarlowModel Female Bradford, England, United Kingdom
Mayhem # 2405516
About MeI've joined this site in hope of building a varied modelling portfolio.
I'm looking to work with creative individuals such as Photographers, Make-up artists and hair stylists on a TFCD (Time For CD) basis to help all parties involved benefit from the results. I'm slightly alternative and do have tattoos.
On the double take photo's i was 8 month pregnant. I am now back to a size 6.
I'm very reliable and will work hard to achieve the desired results.
Unfortunatley due to having a young child i am currently restricted to when i can shoot, I am available Mon afternoon, Wednesday and Friday. Please contact me and I will try accommodate.
I do NOT do fetish or glamour of ANY kind so please do not ask!
I like to take part in creative exciting shoots and am not afraid to try new ideas. I also have many more photos (Upon request).
Thank you for taking the time to look at my profile!
Have you worked with leonnie Barlow? Add Credits for leonnie Barlow! >>
Credit NotesI have worked with:
Jixels Photography
Kay-Leigh Photography
Daz Savage
All are fantastic photographers and would definatley recommend them!!
Georgina Ansell Photographer
laurenpiss... Photographer
Molly Denney Photographer
Emily Nicolle Bailey Photographer
Julie Ellen Photographer
steveyg Photographer
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text:
From Dubai International Film Festival, 'Terminator Salvation' director McG reportedly announced that 'Terminator' will be back for the fifth time.
While "Terminator Salvation" is still months away from its theatrical release, "Terminator 5" could be well in the pipeline. Of it, Variety reported that Halcyon Co. toppers, Derek Anderson and Victor Kubicek, are developing the second movie from the proposed "Terminator" trilogy, with "Terminator Salvation" director McG.
Reportedly, the announcement was made at the Dubai International Film Festival where McG was in for. It is further noted that despite speculation on the using of the Middle East, decision for the filming location has yet to be taken, and that Christian Bale has signed on to reprise his John Connor role for all three films.
While Anderson and Kubicek originally planned to come out with the decision after "Terminator Salvation" hits the big screen, they finally decided to push it forward since they noticed positive reactions from the studio, fans and media to "Terminator Salvation" footage. "We feel the time is now to start shaping the next part of this," Kubicek commented on the decision.
On "Terminator Salvation" itself, it is the fourth installment of the "Terminator" franchise. Set in post-apocalyptic 2018, it follows a stranger whose past could not be justified, Marcus Wright, when he joins John Connor in his resistance army. Starring Christian Bale, the movie also sees Sam Worthington as Marcus Wright and is slated to be released in the U.S. on May 22, 2009.


text:
Opening times not supplied. Please phone Zarraffas Coffee - Harbour Town on (07) 5529 2013
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text:
Cinnamon Crinkles
READY IN: 14mins
Recipe by Berliner Goere
Crunchy on the outside and chewy on the inside. Yum!
Top Review by howmanybites
These cookies are very yummy! I used red sugar sprinkles cause that's all I had on hand, but it would be really fun to use all different colors for the holidays!
See Discussion:1 Review
Ingredients Nutrition
- 1 1⁄2 cups sugar
- 1⁄2 cup butter
- 1⁄2 cup shortening
- 2 large eggs
- 2 3⁄4 cups flour
- 2 teaspoons cream of tartar
- 1 teaspoon baking soda
- 1 teaspoon cinnamon
- 1⁄4 teaspoon salt
- colored sugar sprinkle, to roll cookies in
Directions See How It's Made
- Preheat oven to 375°F/190°C.
- Cream sugar, butter, shortening and eggs.
- In a seperate bowl sift together flour, cream of tartar, baking soda, cinnamon and salt; then beat into butter mix and mix well.
- Shape dough into 1 inch balls, roll in colored sugar and place on cookie sheet.
- Bake for about 9-11 minutes.
- Temperature and time may vary according to your oven's accuracy (just eat the first one after it cooled off).
- Let cookies rest about 10 minutes before removing from cookie sheet.


text:
Back Outlet Pushbutton Assembly, Hot
ACORN| Zoro #: G1490185| Mfr #: 2566-051-001
Zoro #: G1490185Mfr. Part #: 2566-051-001
$47.42 /ea
Orders over $50.00 ship free. DetailsStandard ground shipping
Technical Specifications
|Zoro #: G1490185 Mfr #: 2566-051-001
|Item: Back Outlet Pushbutton Assembly
|Includes: Hot Back Outlet Pushbutton With Nylon Compression Nut
|Type: Hot
|Country of Origin (subject to change): Mexico
Product Description
Back Outlet Pushbutton Assembly, Hot, For Use With Lavatories, Showers, Combination Lavatory And Toilet Pushbuttons, Includes Hot Back Outlet Pushbutton With Nylon Compression Nut
Restrictions and Compliance
- This product is part of the finished good by the same manufacturer which has been certified by a third party to be compliant with the "Safe Drinking Water Act" requirements for low lead in potable (human consumption - drinking and cooking) and non-potable (non-human consumption) water applications.


text:
This is a high quality product, but it is very heavy. I'm not happy with the weight of it.Read More
Perfect pillow, outstanding price. You sink in just a little bit, keeps you cool, your nose/face doesn't get buried in. The neck holder is the high side, I turned it around to use the low side. On cotton sheets, it doesn't slip 'n slide when you move, stays put. The zip off cover is super smooth & refuses to attract dirt. Don't know what it's made of, it stays pure white. Great support for more firm/hard mattress sleeping. Not good for cushy sleeping, tilts the head wrong.Read More
Because I have problems with vertigo and have to elevate my head at night more than I would like, this pillow works perfectly. I additionally have to use a small curved neck pillow for the lift, but the two of them do the trick. If anyone just wanted a curved foam pillow and didn't need the extra one for medical issues, it would also be wonderful and so comfy. I purchased an additional one for a new beach condo because I really can't sleep without it.. Glad I found it on Overstock because I had not seen it in stores at the time - have had my first one for a couple of years - still just like new.Read More
This pillow is very firm and not for everyone, but I liked it. It's not as thick as I thought it would be, but they was probably just my error. It's good for me though. I just stack it on my other pillow and sleep on my side and it really helps me get a good nights sleep without any shoulder or neck pain in the morning and that's all I wanted in the first place. No one in my family likes it, but they all like the plush and fluffy pillows anyway so it's not good for everyone. It's only good for someone who really does like a firm pillow.Read More
Before you buy, however, make sure the measurements given are not going to put your head up high enough to take your head out of alignment and keep those headaches coming. I used mine one night and the headaches are back. The bean and lavender hot neck wrap works exactly as I want. I do like the pillow's construction, and ease of use. I think that i will give it to my son-in-law who has a snoring problem....my daughter will be very grateful. The three rating is my opinion. The pillow would work well for someone else who has a longer distance between head and neck.Read More
The Bodipedic Relaxation Curve Memory Foam Pillow
Today $42.99


text:
FDA panel OK puts Onyx takeover cost at $6 billion
Published 8:18 pm, Tuesday, June 26, 2012
Number of the day
$6 billion
That's how much Onyx Pharmaceuticals could be worth to an acquirer, according to analysts at Stifel Nicolaus, after Food and Drug Administration advisers gave their support last week to the company's new blood-cancer drug. The price is about 40 percent more than the South San Francisco firm's current value. Onyx's allure as a takeover target has increased on speculation that the treatment will be approved as soon as next month.
Hear here
"Isolating the toxic element and separating it into a vehicle for investors who specialize in these things is a good idea."
Latest business videos
Barton Crockett, an analyst with Lazard Capital Markets, on News Corp. possibly spinning off its scandal-plagued newspapers from its entertainment businesses, including Fox TV. Sources say CEO Rupert Murdoch is overseeing internal discussions of the plan after a British investigation into phone hacking at the company's London tabloids threatened its stake in satellite-TV operator BSkyB. News Corp.'s shares jumped 8.3 percent on Tuesday.
Heads up
Lennar Corp., the home builder with developments across the Bay Area, reports quarterly earnings Wednesday. With the U.S. housing market starting to recover from the recession, Wall Street expects Lennar to report net income more than doubled while sales increased 18 percent. Lennar Urban, a division of the company, will develop Hunters Point Naval Shipyard and Candlestick Point as well as Treasure Island.


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Tomato and Basil Quiche
READY IN: 1hr 45mins
Recipe by Evie3234
Homemade quiches are so much nicer than store bought.
Top Review by CelticLass
Very tasty. Even though the crust is very crumbly, I would recommend using it, as opposed to a plain crust, because the butter and lemon juice really add to the overall flavor. I didn't have a leek, so used 1/2 of a mild onion and it worked fine. Reheats very well in the microwave - just don't overdo it.
See Discussion:1 Review
Ingredients Nutrition
- 1 cup flour
- 90 g butter
- 1 egg yolk
- 1 tablespoon lemon juice (approx)
- 30 g butter
- 1 leek
- 3 eggs
- 300 ml whipping cream
- 3⁄4 cup grated cheese
- 3 small ripe tomatoes
- 3⁄4 cup chopped fresh basil
- 1⁄2 cup chopped parsley
- salt
- pepper
- 2 tablespoons parmesan cheese
Directions See How It's Made
- --------Pastry-----------.
- Sift flour into bowl, rub in butter, add egg yolk and enough lemon juice to mix to firm dough.
- Cover.
- Refrigerate 30 minutes.
- Roll out to fit 23 cm flan tin, trim edges.
- Line tin with greaseproof paper, fill with dry beans or rice, bake in mod hot oven for 10 minutes.
- Remove paper and beans, return to oven and bake a further 5 minutes.
- ----------Filling--------------- ¼.
- Melt butter in pan, add sliced leek, cook until tender.
- Combine eggs, cream and cheese in bowl, add leek, pour into pastry case.
- Peel tomatoes, cut into 1 cm slices.
- Roll edge of tomato slices in combined basil and parsley, place on top of leek mixture.
- Sprinkle with salt, pepper and grated parmesan.
- Bake in moderate oven for 30 minutes.


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2-1/2" Welded Black Steel Slip On Flange
VALUE BRAND| Zoro #: G0569755| Mfr #: 4TWY1
Zoro #: G0569755Mfr. Part #: 4TWY1
$20.70 /ea
Orders over $50.00 ship free. DetailsStandard ground shipping
Technical Specifications
|Zoro #: G0569755 Mfr #: 4TWY1
|Max. Pressure: 150 psi@450 Degrees F
|Fitting Schedule/Class: Class 150
|Pipe Fitting Material: Black Steel
|Fitting Connection Type: Welded
|Standards: ASTM A-197, ASTM A47, ASME B16.3 and B16.4, UL Listed, FM Approved
|Specific Fitting Shape: Slip On Flange
|Item: Slip On Flange
|Basic Fitting Material: Metal
|Basic Fitting Shape: Flange
|Saturated Steam Pressure: 150 PSI
|Pipe Size (Fittings): 2-1/2"
|Country of Origin (subject to change): China
Product Description
Whether you are connecting a water line or gas line, this slip on flange from Value Brand will fit right in. This slip on flange black pipe features dependable Class 150 Welded fitting connection types with a max pressure of 150 psi@450 Degrees F. It fits a pipe size of 2-1/2".


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The College is applying for an exemption from a city regulation that requires one parking space for every two beds. With the North Professor Street construction bringing 160 new beds to campus, the City's code dictates that the College create over 80 parking spaces. To apply for variance, the College must meet 20 different qualifications.
Oberlin Finalizes Negotiations with Stevie Wonder
The College is in the final stages of contract negotiations with Stevie Wonder. They expect that he will perform at the inauguration of the new Litoff jazz building on May 1. The deal will be finalized this week; we will bring you all the details as soon as we can.
Digital Signs "Wow…that's cool."
Seven digital signs now grace Oberlin's high traffic areas, displaying banners for student organizations and College departments, College events, a live energy monitoring feed, news crawl and the time, date and weather, in the hopes of keeping students more informed of campus events. Continue reading
Airport Shuttle $5 During Breaks, $10 Regular
Lorain County Transit cut Route 33, which ran from Oberlin College to the Cleveland-Hopkins Airport, this summer when faced with an $880,000 budget deficit. The College has entered into an agreement with an alternate company, Airport Oberlin Shuttle Service, to keep a route to the airport open. Continue reading
Over Enrollment – Housing Effects
Last year, the College over enrolled by 40 students. This year, we've over enrolled by 98. ResEd has been scrambling to house the 98 additional students, resulting in the reduction of super singles and super quads, the acquisition of 3 village houses, and the placement of students in program houses and temporarily in converted lounges. Continue reading
Burton and Lord/Saunders Renovations Picture Tour
Thanks to the economy, the Burton and Lord/Saunders renovation projects came in under budget, allowing the College to renovate everything that it wanted and still save money.
"The bids came in under what we had budgeted," said Molly Tyson, Dean of ResEd. "So it's not cost savings because we're doing less, it's cost savings because of the economy. We're getting more for our money." Continue reading
Preview: The OC
In the next two days, another class of Oberlin students will be initiated into the College through The OC, a staple of orientation for about 20 years.
The New Class
Statistics Courtesy of the Office of Admissions
Who they are:
Almost 6,000 people applied to the College of Arts and Sciences
12 years of record applicant numbers for the College
1,400 people applied to the Conservatory
10 years of record applicant numbers for the Conservatory
CIT: Safe Connect Cannot See Files, Won't Limit P2P
An email sent out by CIT on August 12th concerning Safe Connect, the new Network Access Control system, inspired a small student reaction that caused CIT to put the program on hold. CIT will hold two open forums on the weeks of September 14th and 21st to present their plan to students directly and walk them through it.


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Hortonworks FAQ
- How do I schedule an exam?
You need to create an account at www.examslocal.com. Once you are registered and logged in, select "Schedule an Exam", and then enter "Hortonworks" in the "Search Here" field to locate and select the specific exam you want to register for.
- Can I attempt a Hortonworks Certification exam from anywhere?
Yes. All you need is a webcam and good Internet access.
- What are the minimum requirements of my computer?
The exam environment uses a remote display with a resolution of 1600 x 900. Before starting the exam, candidates should configure a monitor resolution larger than 1600 x 900. Candidates should also use the PSI compatibility check tool at the following URL prior to starting an exam: https://www.examslocal.com/ScheduleExam/Home/CompatibilityCheck
- Am I allowed access to documentation?
Yes. Candidates for the HDPCD exam are provided access to the Pig, Hive, Sqoop and Flume documentation pages. Candidates for the HDPCA exam are provided access to the HPD 2.3 documentation pages.
- Do you provide a practice exam?
Yes. Hortonworks highly encourages candidates to attempt the corresponding practice exam. The practice exam contains sample tasks similar to those on the actual exam and uses the same environment. The details of how to take the HDPCD practice exam can be found here: http://hortonworks.com/training/class/hdp-certified-developer-hdpcd-exam/.
- How do I reschedule or cancel an Exam Reservation?
If you need to reschedule an exam, you must cancel it and sign up for a new one. If you purchased your exam using a credit card, your card will be refunded the exam amount. Sign in at https://www.examslocal.com/, click on "My Exams", click on your scheduled exam and use the cancellation option. Email PSI at firstname.lastname@example.com, or call +1-888-504-9178, +1-312-612-1049 for additional support.
- What is the cancellation policy for my scheduled exam?
Exams must be canceled at least 24 hours before the scheduled exam time. Failing to cancel within this time period will result in forfeiture of exam fees, and your exam credit will be considered used.
- How can I retrieve a forgotten password?
To retrieve a forgotten password please visit: https://www.examslocal.com/Account/LostPassword
- What will happen if I do not show up for my exam?
By not showing up to your exam reservation on time, you will be marked as a no-show for the exam. No-shows forfeit the money paid for an exam, and you will need to pay for a new exam registration.
- What do I need on the day of my exam?
- One form of government issued photo identification (i.e. driver's license, passport). Any international passport or government issued form of identification must contain Western (English) characters. You will be required to provide a means of photo identification before the exam can be launched. If acceptable proof of identification is not provided to the proctor prior to the exam, entry to the exam will be refused. You must also consent to having your photo taken. The ID will be used for identity verification only and will not be stored. The proctor cannot release the exam to you until identification has been successfully verified and you have agreed to the terms and conditions of the exam. No refund or rescheduling is provided when an exam cannot be started due to failure to provide proper identification.
- A monitor with screen resolution larger than 1600 x 900.
- A computer that meets the minimum requirements provided within the compatibility check: https://www.examslocal.com/ScheduleExam/Home/Compatibility Check
- How do I launch my exam?
To start your exam, login at https://www.examslocal.com/, click "My Exams", and follow the instructions after selecting the exam that you want to start.
- At what time should I launch my exam?
You may start your exam up to 15 minutes before your scheduled start time. You MUST start your exam no later than 15 minutes after your scheduled start time. If you do not start your exam within 15 minutes of your scheduled start time, the system will automatically mark you as a No-Show and you will not be able to take your exam.
- Will the proctor be able to access my computer or its contents?
PSI does not install any software on your computer for this exam and, therefore, does not have any access to your computer or its contents. The only access PSI has to your computer is the webcam and desktop sharing facilitated by your web browser. However, please note that PSI does provide a virtual lockdown browser system that utilizes secure communications and encryption. Upon the completion of the exam all proctor "view-only access" is automatically removed.
- How long do I have to complete the exam?
You have 120 minutes (2 hours) to complete the exam.
- When does the timer begin?
The timer for your exam does not start until the proctor has launched the exam.
- When can I expect to receive the results of my exam?
Please allow up to 5 business days to receive your exam results via e-mail from Hortonworks. If after 5 business days you still have not received your results please contact Hortonworks directly at email@example.com
- If I pass the exam, what type of certificate do I receive?
As an HDP Certified Professional, you will receive a digital badge that verifies your certification. Display this badge proudly on your résumé, LinkedIn profile, email signature, forums, etc.
- If I fail an exam, how soon can I retake it?
After you have been emailed the results of your exam, then you can register and take the exam again. You cannot register for a new exam until after you receive the results of the most recent attempt.


text:
I couldn't help myself any longer and had a mini photo shoot with Ayala this past weekend and thanks to my amazing 14yo daughter, I now have a café/bakery/bistro/etc. for Ayala too! (n.n)
We are still working on it but I LOVE it! I chose the colors and I'm so happy with how it turned out because not only can it serve as bakery but a bedroom too! This will be Ayala's bedroom when not in bakery/café mode. (^_^) I hope to get better pictures when the sun is in the right position for indoor photos but enjoy the sneak peek of Ayala's space.