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|Clinical data
|Trade names
|License data
|Routes of
|By mouth
|ATC code
|Legal status
|Legal status
|Pharmacokinetic data
|Protein binding
|Limited (<10%)
|Biological half-life
|24 hours
|Renal (81–92%)
|CAS Number
|PubChem CID
|Chemical and physical data
|Molar mass
|211.267 g/mol
|3D model (JSmol)
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Varenicline (trade name Chantix and Champix), is a prescription medication used to treat nicotine addiction. Varenicline is a nicotinic receptor partial agonist—it stimulates nicotine receptors more weakly than nicotine itself does. In this respect it is similar to cytisine and different from the nicotinic antagonist bupropion and nicotine replacement therapies (NRTs) like nicotine patches and nicotine gum. As a partial agonist it both reduces cravings for and decreases the pleasurable effects of cigarettes and other tobacco products. Through these mechanisms it can assist some patients to quit smoking.
Medical uses[edit]
Varenicline is used for smoking cessation. In a 2009 meta-analysis varenicline was found to be more effective than bupropion (odds ratio 1.40) and NRTs (odds ratio 1.56).[1]
A 2013 Cochrane overview and network meta-analysis concluded that varenicline is the most effective medication for tobacco cessation and that smokers were nearly three times more likely to quit on varenicline than with placebo treatment. Varenicline was more efficacious than bupropion or NRT and as effective as combination NRT for tobacco smoking cessation.[2][3]
The United States' Food and Drug Administration (US FDA) has approved the use of varenicline for up to twelve weeks. If smoking cessation has been achieved it may be continued for another twelve weeks.[4]
Varenicline has not been tested in those under 18 years old or pregnant women and therefore is not recommended for use by these groups.[5] Varenicline is considered a class C pregnancy drug, as animal studies have shown no increased risk of congenital anomalies, however, no data from human studies is available.[6] An observational study is currently being conducted assessing for malformations related to varenicline exposure, but has no results yet.[7] An alternate drug is preferred for smoking cessation during breastfeeding due to lack of information and based on the animal studies on nicotine.[8]
Side effects[edit]
Mild nausea is the most common side effect and is seen in approximately 30% of people taking varenicline though this rarely (<3%) results in discontinuation of the medication.[3] Other less common side effects include headache, difficulty sleeping, and nightmares. Rare side effects reported by people taking varenicline compared to placebo include change in taste, vomiting, abdominal pain, flatulence, and constipation. It has been estimated that for every five subjects taking varenicline at maintenance doses, there will be an event of nausea, and for every 24 and 35 treated subjects, there will be an event of constipation and flatulence respectively. Gastrointestinal side-effects lead to discontinuation of the drug in 2% to 8% of people using varenicline.[9][10] Incidence of nausea is dose-dependent: incidence of nausea was higher in people taking a larger dose (30%) versus placebo (10%) as compared to people taking a smaller dose (16%) versus placebo (11%).[11]
Depression and suicide[edit]
A 2014 systematic review did not find evidence of an increased suicide risk.[12] Other analyses have reached the same conclusion and found no increased risk of neuropsychiatric side effects with varenicline.[2][3] No evidence for increased risks of cardiovascular events, depression, or self-harm with varenicline versus nicotine replacement therapy has been found in one post-marketing surveillance study.[13]
In 2007, the US FDA had announced it had received post-marketing reports of thoughts of suicide and occasional suicidal behavior, erratic behavior, and drowsiness among people using varenicline for smoking cessation. In 2009, the US FDA required varenicline to carry a boxed warning that the drug should be stopped if any of these symptoms are experienced.[14] In 2016 the FDA removed the black box warning.[15] People are still advised to stop the medication if they "notice any side effects on mood, behavior, or thinking."[15][16][17]
Cardiovascular disease[edit]
In June 2011, the US FDA issued a safety announcement that varenicline may be associated with "a small, increased risk of certain cardiovascular adverse events in people who have cardiovascular disease."[18]
A prior 2011 review had found increased risk of cardiovascular events compared with placebo.[19] Expert commentary in the same journal raised doubts about the methodology of the review,[20][21] concerns which were echoed by the European Medicines Agency and subsequent reviews.[22][23] Of specific concern were "the low number of events seen, the types of events counted, the higher drop-out rate in people receiving placebo, the lack of information on the timing of events, and the exclusion of studies in which no-one had an event."
In contrast, multiple recent systematic reviews and meta-analyses have found no increase in overall or serious adverse cardiovascular events (including for individuals at risk of developing cardiovascular disease) associated with varenicline use.[23][24][25][26]
Mechanism of action[edit]
Varenicline displays full agonism on α7 nicotinic acetylcholine receptors and is a partial agonist on the α4β2, α3β4, and α6β2 subtypes.[27][28][29] In addition, it is a weak agonist on the α3β2 containing receptors.
Varenicline's partial agonism on the α4β2 receptors rather than nicotine's full agonism produces less effect of dopamine release than nicotine's. This α4β2 competitive binding reduces the ability of nicotine to bind and stimulate the mesolimbic dopamine system - similar to the method of action of buprenorphine in the treatment of opioid addiction.[3]
Most of the active compound is excreted by the kidneys (92–93%). A small proportion is glucuronidated, oxidised, N-formylated or conjugated to a hexose.[30] The elimination half-life is about 24 hours.
Use of Cytisus plant as a smoking substitute during World War II[31] led to use as a cessation aid in eastern Europe and extraction of cytisine.[32] Cytisine analogs led to varenicline at Pfizer.[33][34][35]
Varenicline received a "priority review" by the US FDA in February 2006, shortening the usual 10-month review period to 6 months because of its demonstrated effectiveness in clinical trials and perceived lack of safety issues.[36] The agency's approval of the drug came on May 11, 2006.[4] On August 1, 2006, varenicline was made available for sale in the United States and on September 29, 2006, was approved for sale in the European Union.[37]
See also[edit]
- ^ Mills EJ, Wu P, Spurden D, Ebbert JO, Wilson K (2009). "Efficacy of pharmacotherapies for short-term smoking abstinance: a systematic review and meta-analysis" (PDF). Harm Reduct J. 6: 25. PMC 2760513 . PMID 19761618. doi:10.1186/1477-7517-6-25.
- ^ a b Cahill K, Stevens S, Perera R, Lancaster T (May 2013). "Pharmacological interventions for smoking cessation: an overview and network meta-analysis". Cochrane Database Syst Rev (Systematic Review & Meta-Analysis). 5 (5): CD009329. PMID 23728690. doi:10.1002/14651858.CD009329.pub2.
- ^ a b c d Elrashidi MY, Ebbert JO (June 2014). "Emerging drugs for the treatment of tobacco dependence: 2014 update". Expert Opin Emerg Drug (Review). 19 (2): 243–60. PMID 24654737. doi:10.1517/14728214.2014.899580.
- ^ a b U.S. Food and Drug Administration.FDA Approves Novel Medication for Smoking Cessation. Press release, 11 May 2006.
- ^ Coleman, Tim; Chamberlain, Catherine; Davey, Mary-Ann; Cooper, Sue E; Leonardi-Bee, Jo; Coleman, Tim (2015). "Pharmacological interventions for promoting smoking cessation during pregnancy". Reviews. doi:10.1002/14651858.CD010078.pub2.
- ^ Cressman, AM; Pupco, A; Kim, E; Koren, G; Bozzo, P (May 2012). "Smoking cessation therapy during pregnancy.". Canadian Family Physician. 58 (5): 525–7. PMC 3352787 . PMID 22586193.
- ^ "Varenicline Pregnancy Cohort Study". clinicaltrials.gov.
- ^ "LactMed". nih.gov.
- ^ Leung, LK; Patafio, FM; Rosser, WW (September 28, 2011). "Gastrointestinal adverse effects of varenicline at maintenance dose: a meta-analysis". BMC clinical pharmacology. 11 (1): 15. PMC 3192741 . PMID 21955317. doi:10.1186/1472-6904-11-15.
- ^ American Cancer Society. "Cancer Drug Guide: Varenicline". Retrieved 2008-01-19.
- ^ "DailyMed - CHANTIX- varenicline tartrate". nih.gov.
- ^ Hughes, JR (8 January 2015). "Varenicline as a Cause of Suicidal Outcomes". Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. 18 (1): 2–9. PMID 25572451. doi:10.1093/ntr/ntu275.
- ^ Kotz D, Viechtbauer W, Simpson C, van Schayck OC, West R, Sheikh A (2015). "Cardiovascular and neuropsychiatric risks of varenicline: a retrospective cohort study". Lancet Respir Med (retrospective cohort). 3 (10): 761–768. PMC 4593936 . PMID 26355008. doi:10.1016/S2213-2600(15)00320-3.
- ^ FDA. "Public Health Advisory: FDA Requires New Boxed Warnings for the Smoking Cessation Drugs Chantix and Zyban". Retrieved 2009-07-01.
- ^ a b Commissioner, Office of the. "Safety Alerts for Human Medical Products - Chantix (varenicline) and Zyban (bupropion): Drug Safety Communication - Mental Health Side Effects Revised". www.fda.gov. Retrieved 20 December 2016.
- ^ Yeung, EYH; Long, S; Bachi, BL; Lee, J; Chao, Y (2015-01-14). "The psychiatric effects of varenicline on patients with depression". BMC Proceedings. 9 (Suppl 1): A31. ISSN 1753-6561. PMC 4306032 . doi:10.1186/1753-6561-9-S1-A31.
- ^ Yeung, E; Bachi, B; Long, S; Lee, J; Chao, Y (2015). "Varenicline and Depression: a Literature Review" (PDF). World Journal of Medical Education and Research. 9 (1): 24–29.
- ^ "FDA Drug Safety Communication: Chantix (varenicline) may increase the risk of certain cardiovascular adverse events in patients with cardiovascular disease". 2011-06-16.
- ^ Singh, S; Loke, YK, Spangler, JG, Furberg, CD (Sep 6, 2011). "Risk of serious adverse cardiovascular events associated with varenicline: a systematic review and meta-analysis" (PDF). CMAJ : Canadian Medical Association. 183 (12): 1359–66. PMC 3168618 . PMID 21727225. doi:10.1503/cmaj.110218.
- ^ Takagi, H; Umemoto, T (Sep 6, 2011). "Varenicline: quantifying the risk". CMAJ : Canadian Medical Association. 183 (12): 1404. PMC 3168634 . PMID 21896705. doi:10.1503/cmaj.111-2063.
- ^ Samuels, L (Sep 6, 2011). "Varenicline: cardiovascular safety". CMAJ : Canadian Medical Association. 183 (12): 1407–08. PMC 3168639 . PMID 21896709. doi:10.1503/cmaj.111-2073.
- ^ "European Medicine Agency confirms positive benefit-risk balance for Champix.". 2011-07-21.
- ^ a b Prochaska JJ, Hilton JF (2012). "Risk of cardiovascular serious adverse events associated with varenicline use for tobacco cessation: systematic review and meta-analysis". BMJ (Systematic Review & Meta-Analysis). 344: e2856. PMC 3344735 . PMID 22563098. doi:10.1136/bmj.e2856.
- ^ Mills EJ, Thorlund K, Eapen S, Wu P, Prochaska JJ (January 2014). "Cardiovascular events associated with smoking cessation pharmacotherapies: a network meta-analysis". Circulation (Network Meta-Analysis). 129 (1): 28–41. PMC 4258065 . PMID 24323793. doi:10.1161/CIRCULATIONAHA.113.003961.
- ^ Pipe AL (October 2014). "Network meta-analysis demonstrates the safety of pharmacotherapy for smoking cessation in cardiovascular patients". Evidence-Based Medicine (Review & Commentary). 19 (5): 193. PMID 24917603. doi:10.1136/eb-2014-110030.
- ^ Rowland K (April 2014). "ACP Journal Club. Review: Nicotine replacement therapy increases CVD events; bupropion and varenicline do not". Annals of Internal Medicine (Review & Commentary). 160 (8): JC2. PMID 24733219. doi:10.7326/0003-4819-160-8-201404150-02002.
- ^ Mihalak KB, Carroll FI, Luetje CW; Carroll; Luetje (2006). "Varenicline is a partial agonist at alpha4beta2 and a full agonist at alpha7 neuronal nicotinic receptors". Mol. Pharmacol. 70 (3): 801–805. PMID 16766716. doi:10.1124/mol.106.025130.
- ^ Mineur YS, Picciotto MR; Picciotto (December 2010). "Nicotine receptors and depression: revisiting and revising the cholinergic hypothesis". Trends Pharmacol. Sci. 31 (12): 580–6. PMC 2991594 . PMID 20965579. doi:10.1016/j.tips.2010.09.004.
- ^ Tanuja Bordia. "Varenicline Is a Potent Partial Agonist at α6β2* Nicotinic Acetylcholine Receptors in Rat and Monkey Striatum". aspetjournals.org.
- ^ Obach, RS; Reed-Hagen, AE; Krueger, SS; Obach, BJ; O'Connell, TN; Zandi, KS; Miller, S; Coe, JW (2006). "Metabolism and disposition of varenicline, a selective alpha4beta2 acetylcholine receptor partial agonist, in vivo and in vitro". Drug metabolism and disposition: the biological fate of chemicals. 34 (1): 121–130. PMID 16221753. doi:10.1124/dmd.105.006767.
- ^ Seeger, R (Jan 1992). "[Cytisine as an aid for smoking cessation].". Med Monatsschr Pharm. 15 (1): 20–1. PMID 1542278.
- ^ Prochaska, BMJ 347:f5198 2013 http://www.bmj.com/content/347/bmj.f5198
- ^ Coe JW, Brooks PR, Vetelino MG, Wirtz MC, Arnold EP, Huang J, Sands SB, Davis TI, Lebel LA, Fox CB, Shrikhande A, Heym JH, Schaeffer E, Rollema H, Lu Y, Mansbach RS, Chambers LK, Rovetti CC, Schulz DW, Tingley FD 3rd, O'Neill BT (2005). "Varenicline: an alpha4beta2 nicotinic receptor partial agonist for smoking cessation". J. Med. Chem. 48 (10): 3474–3477. PMID 15887955. doi:10.1021/jm050069n.
- ^ Schwartz JL (1979). "Review and evaluation of methods of smoking cessation, 1969–77. Summary of a monograph". Public Health Rep. 94 (6): 558–63. PMC 1431736 . PMID 515342.
- ^ Etter JF (2006). "Cytisine for smoking cessation: a literature review and a meta-analysis". Arch. Intern. Med. 166 (15): 1553–1559. PMID 16908787. doi:10.1001/archinte.166.15.1553.
- ^ Kuehn BM (2006). "FDA speeds smoking cessation drug review". JAMA. 295 (6): 614–614. PMID 16467225. doi:10.1001/jama.295.6.614.
- ^ European Medicines Agency (2011-01-28). "EPAR summary for the public. Champix varenicline". London. Retrieved 2011-02-14.
External links[edit]
|Wikinews has related news: New drug for smoking cessation is under investigation


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Best Rated Laptops Under 700 Dollars
Every year laptops drop in price, nowadays we have access to a bunch of affordable laptops from several name brands. Check out the best laptops under 700 dollars for 2014-2015, delve into some customer reviews, and pick which one you like best!
The author of this page is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon. Certain content that appears on this site comes from Amazon Services LLC. This content is provided 'as is' and is subject to change or removal at any time.

subset: commoncrawl


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- Home >
- Accessories >
- Machinery Accessories >
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- Axcaliber GT Bandsaw Blades from 1,854mm (73")
Available exclusively at Axminster, this newly developed material is really designed for the production user with high feed rates of cutting but we loved the diamond ground teeth and the results obtained so much that we felt everyone should have an opportunity to try these out, whatever the job!
The diamond ground teeth are so unbelievably sharp that the blades work extremely well in all materials giving an exceptionally high quality finish and clean cut, plus they stay sharp for at least 30% longer than normal, milled tooth blades. Made of a unique steel ideally suited to the rigours of running on two wheels, the annealed and highly finished weld provides the perfect blade for any of the machines in the Axminster programme with blade lengths of 1,854mm or 73" and above.
Overall rating 5 reviews4.9 out of 5 based on
23 March 2017
BrilliantBought two of these blades for my large bandsaw which I have struggled with for years using the manufacturer's supplied blades. What a difference ! I now have the capability that I bought the machine for in the first place. With these blades the machine now cuts straight and true as it should have done freom the start. Will never buy anything else now.
12 February 2017
ExcellentBought these after using a blade supplied with a Record Power machine and it transformed the quality and ease of the cut leaving a really smooth surface on the timber, will stick with these now.
16 August 2016
Never going backI have used most blades. These are sheer value coupled with longetivity. I will be ordering more, I mainly use these for cutting veeneer from Cherry and Walnut, with the occaisonal Robinia thrown in.
Simon Harrison Furniture
18 June 2015
Best blades so farBrilliant blades well worth the money. The quality of the cut is excellent and they last longer, try one and you will not go back.
29 January 2015
ExcellentI bought this blade after using blades supplied with a new bandsaw which all left a very rough surface. This blade transformed the job. Not expensive and definitely recommended


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Nobel Peace Prize winner Malala Yousafzai, a young woman from Pakistan, was denied the privilege of attending school, shot by terrorists, and forced to leave her country. Her near assassination convinced Malala that God had kept her alive for a reason. She would continue to fight for children's rights to education. With 66 million children worldwide not attending school, Malala travels the world, inspiring politicians and other people to help them. "We should not lose hope," she said. "One child, one teacher, one book, and one pen can change the world."
Using the graphics, students can activate prior knowledge--bridge what they already know with what they have yet to learn. Graphically illustrated biographies also teach inference skills, character development, dialogue, transitions, and drawing conclusions. Graphic biographies in the classroom provide an intervention with proven success for the struggling reader.
W. E. B. Du Bois was born a few years after the end of the Civil War, and he dedicated his life to the fight for racial equality. Du Bois was highly educated, and he used his knowledge to speak out against segregation and the commonly held belief that blacks were inferior to whites.
This title examines the fascinating life of Eminem. Readers will learn about Eminem's childhood, family, education, rise to fame, trouble with drugs and the law, his time in rehab, as well as controversies over his lyrics and songs. Colorful graphics, oversize photos, and informative sidebars accompany easy-to-read, compelling text that explores Eminem's early interest in music and talent in songwriting that led to his freestyle raps and eventually the release of his albums Infinite, The Slim Shady LP, The Marshall Mathers LP, The Eminem Show, Encore, Relapse, and Recovery. Eminem's acting debut in the move 8 Mile, his Grammy Awards, and his Oscar for Best Original Song are also described. Features include a table of contents, glossary, selected bibliography, Web links, source notes, and an index, plus a timeline and fun facts. Contemporary Lives is a series in Essential Library, an imprint of ABDO Publishing Company.
This title examines an important historic event - the civil rights movement. Easy-to-read, compelling text explores the history of racism and civil rights in the United States from slavery to segregation, the roles the Montgomery bus boycott, the integration at Little Rock Central High School, and the Birmingham campaign played in the movement, key African-American activists such as Martin Luther King Jr. and Rosa Parks, and the effects of this event on society. Features include a table of contents, a timeline, facts, additional resources, Web sites, a glossary, a bibliography, and an index. Essential Events is a series in Essential Library, an imprint of ABDO Publishing Company.
This title examines an important historic event - the women's suffrage movement. Easy-to-read, compelling text explores the history of women's rights and the League of Women Voters, the roles the antislavery movement, the Fourteenth and Fifteenth Amendments, and literature played in the movement, well-known figures such as Mary Wollstonecraft, Lucy Stone, Susan B. Anthony, and Alice Paul, and the effects of this event on society. Features include a table of contents, a timeline, facts, additional resources, Web sites, a glossary, a bibliography, and an index. Essential Events is a series in Essential Library, an imprint of ABDO Publishing Company.
In 1845, Frederick Douglasss first autobiography became a bestseller. Many readers could not believe that such a brilliant writer was ever a slave. When Douglass wrote the book, slavery had not yet ended so he kept secret how he escaped from Maryland. By 1881, the Civil War had ended slavery and Douglass felt the time was right to reveal how he escaped. This play is adapted from Douglasss own words from The Life and Times of Frederick Douglass.


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FARMERS from the island of Crete are clashing with police outside Greece's parliament as MPs prepare to vote on a new property tax that will extend the levy to include farms.
Hundreds of farmers took an overnight ferry to protest in Athens on Friday.
They hurled oranges at riot police and battered the shields police were holding with traditional shepherds' walking sticks.
The new tax is part of measures required under Greece's international bailout agreements.
Originally published as Farmers clash with police in Greece


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The Mallards weren't part of an IHL trade season that coaches learned had been extended a week just one day ahead of the original March 12 deadline.
"They forgot to tell us earlier in the year," Mallards coach Frank Anzalone said of an extension that was made because the season is one week longer than last year's. "They just forgot."
The IHL brass also didn't make a peep about a deal last week that might have changed the shape of the fourth-place race.
Last-place Dayton sent top scorer John Snowden (22 goals, 24 assists) and veteran defenseman Preston Briggs (5, 10) to fourth-place Bloomington for rookie forward Greg McCauley (2 ,5).
"It's an interesting trade," said Anzalone, whose Mallards are chasing Bloomington for the final playoff berth. "If it happened in the NHL, someone would question it."
Anzalone said Dayton probably was looking to lose salary and said Gems coach John Marks told him weeks earlier he planned to assemble a young core for next season.
"The strategy is good and if their fans are accepting, I suppose it's OK," he said. "But that's an interesting trade. That's an interesting trade."
Fultz expected to return
Veteran winger Ryan Fultz is not the center Anzalone hoped to add to his late-season roster, but the coach said Fultz, back off 30-day injured reserve, likely will be added this week to a roster that probably will close the campaign.
"Probably going to have to activate him," Anzalone said of what seems to be an organizational decision. "I don't have many other choices."
Fultz had surgery on a toe last month. He had four goals and 13 assists in 41 games and filled in on defense on occasion.
"I've always wanted to be here, doing the best I can for the team," Fultz said. "When they need me, they need me and, hopefully, it's now."
Firefighters on ice
Firefighters from the Quad-Cities and Chicago will clash in advance of an April 10 Mallards game vs. Bloomington at the i wireless Center.
The game will take place at 3 p.m., with $14 tickets including admission to that night's Mallards contest.
Half of the proceeds will aid fundraising efforts for veteran East Moline firefighter Pat Francois, who is battling cancer, and for the Wounded Warrior Project.
Saturday: Muskegon
When: 6 p.m.
Where: L.C. Walker Arena, Muskegon, Mich.
What you need to know: The Mallards will have played back-to-back games at L.C. Walker - six days apart. Only one more meeting - ever - between the two teams awaits April 3 in Michigan. The Lumberjacks will make way next year for a USHL junior team. ... The Mallards fell to 3-5-2-2 vs. the 'Jacks with Sunday's 5-2 loss in Muskegon. ... Muskegon (44-18-0-3) has won four of its past five, with two of those wins over the Mallards, and remains in first place. The 'Jacks lead Fort Wayne by six standings points. ... Todd Robinson, with 19 goals and 79 assists, is two points shy of 100 for the season. Robin Bouchard, who became minor-league hockey's all-time goals leader Sunday, has 56 goals and 38 assists and is six points shy of 100.
Sunday: Dayton
When: 4 p.m.
Where: i wireless Center, Moline
What you need to know: The Gems (23-38-3-1) haven't beaten anybody but the Mallards since Feb. 6, but they have beaten the Mallards four times in that span, which encompasses 19 games. ... The Mallards are 3-5-0-1 against the league's last-place team. ... Dayton is 10-21-2-0 on the road, but 2-3-0-0 at the iwC. ... The Gems lost two straight last weekend and were outscored 9-2 after what amounts to a white-flag trade of leading scorer John Snowden and defenseman Preston Briggs to Bloomington. ... The Gems have outscored the Mallards 4.22 to 3.56.


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Right, so I just had a 2k smurf in my 1470 game. Last pick, decides to go roaming j4 instead of support.
Well, as you can guess this did not work out so well, MF went 3/12, and bot was pushed up to second tower in 15 mins.
But the Jarvan wasn't doing too bad. I mean, he was ok. At the end of the game, he was 12/8. But, we still lost the game, and it was still his fault. Why?
Cuz he screwed up the team comp.
I know, I know, that sounds a stupid, and lame, and I'm going to be called a meta sheep for this, but I just want to makeone thing straight. I am NOT defending the meta. I actually think the meta is a little boring, but the thing is, the meta is a useful concept in low to mid elo.
Think about it, the Meta team comp only give a significant advantage in a game is the opposing team isn't playing a meta comp too. So why does everyone in low to mid elo play the meta? It's because the "concept" of a meta gives low to mid elo players a framework to work with. Everyone knows what's going on, and who's doing what, and as a result, teamwork emerges from the "meta comp". They know who's initiating, who's doing damage, who's peeling and who's healing.
Now, you don't see as much meta in high elo. This is because everyone already knows what's going on.
But for Low to Mid Elo, the meta is god.


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Long-acting beta-agonist (LABA) therapy improves symptoms in patients whose asthma is poorly controlled by an inhaled glucocorticoid alone. Alternative treatments for adults with uncontrolled asthma are needed.
In a three-way, double-blind, triple-dummy crossover trial involving 210 patients with asthma, we evaluated the addition of tiotropium bromide (a long-acting anticholinergic agent approved for the treatment of chronic obstructive pulmonary disease but not asthma) to an inhaled glucocorticoid, as compared with a doubling of the dose of the inhaled glucocorticoid (primary superiority comparison) or the addition of the LABA salmeterol (secondary noninferiority comparison).
The use of tiotropium resulted in a superior primary outcome, as compared with a doubling of the dose of an inhaled glucocorticoid, as assessed by measuring the morning peak expiratory flow (PEF), with a mean difference of 25.8 liters per minute (P<0.001) and superiority in most secondary outcomes, including evening PEF, with a difference of 35.3 liters per minute (P<0.001); the proportion of asthma-control days, with a difference of 0.079 (P=0.01); the forced expiratory volume in 1 second (FEV1) before bronchodilation, with a difference of 0.10 liters (P=0.004); and daily symptom scores, with a difference of -0.11 points (P<0.001). The addition of tiotropium was also noninferior to the addition of salmeterol for all assessed outcomes and increased the prebronchodilator FEV1 more than did salmeterol, with a difference of 0.11 liters (P=0.003).
When added to an inhaled glucocorticoid, tiotropium improved symptoms and lung function in patients with inadequately controlled asthma. Its effects appeared to be equivalent to those with the addition of salmeterol. (Funded by the National Heart, Lung, and Blood Institute; ClinicalTrials.gov number, NCT00565266.).
Wake Forest University Health Sciences, Center for Genomics and Personalized Medicine Research, Medical Center Blvd., Winston-Salem, NC 27157, USA. firstname.lastname@example.com
This article was published in the following journal.
Name: The New England journal of medicine
Pages: 1715-26
Efficacy and safety of tiotropium in school-age children with moderate to severe symptomatic asthma: A Systematic Review.
Recently published data support the benefits and safety of the once-daily (OD) long-acting anticholinergic tiotropium bromide bronchodilator for the treatment of uncontrolled moderate to severe asthma...
Effect of azithromycin on asthma exacerbations and quality of life in adults with persistent uncontrolled asthma (AMAZES): a randomised, double-blind, placebo-controlled trial.
Exacerbations of asthma cause a substantial global illness burden. Adults with uncontrolled persistent asthma despite maintenance treatment require additional therapy. Since macrolide antibiotics can ...
A phase III randomized controlled trial of tiotropium add-on therapy in children with severe symptomatic asthma.
Studies in adults and adolescents have demonstrated that tiotropium is efficacious as an add-on therapy to inhaled corticosteroids (ICS) with or without other maintenance therapies in patients with mo...
Role of muscarinic antagonists in asthma therapy.
Higher parasympathetic tone has been reported in asthmatics. In general, cholinergic contractile tone is increased by airway inflammation associated with asthma. Nevertheless, the role of muscarinic a...
Indirect comparison of bronchial thermoplasty versus omalizumab for uncontrolled severe asthma.
Bronchial thermoplasty (BT) as an add-on therapy for uncontrolled severe asthma is an alternative to biologic therapies like omalizumab (OM). We conducted an indirect treatment comparison (ITC) to app...
Study to Investigate the Effect of Inhaled Tiotropium Bromide on Neurokinin-A Induced Bronchoconstriction in Patients With Mild-to-moderate Asthma
This trial compares the outcome of treatment of mild to moderate asthma: inhaled tiotropium bromide versus placebo.
Evaluation of Tiotropium 2.5 and 5 mcg Once Daily Delivered Via the Respimat® Inhaler Compared to Placebo in 1 to 5 Year Old Patients With Persistent Asthma
The primary objective of this trial is to evaluate the safety and efficacy of two doses of tiotropium inhalation solution delivered via the Respimat® inhaler once daily in the afternoon i...
Asthma Clinical Research Network (ACRN) Trial - Tiotropium Bromide as an Alternative to Increased Inhaled Corticosteroid in Patients Inadequately Controlled on a Lower Dose of Inhaled Corticosteroid (TALC)
Typically, people with asthma are initially prescribed a low dose of inhaled corticosteroid (ICS) medication to control asthma symptoms. If a low dose of ICS is ineffective at controlling ...
Tiotropium Bromide Alone vs Tiotropium Bromide and Formoterol Fumarate in Subjects With COPD (Study P04272) (COMPLETED)
This study is being conducted to determine if the co-administration of formoterol fumarate and tiotropium bromide is more effective than the use of tiotropium bromide alone in patients wit...
An Efficacy and Safety Evaluation of Tiotropium add-on Therapy in Patients With Severe Persistent Asthma
The primary objective of this study is to examine efficacy and safety of tiotropium compared to plac ebo as add-on therapy in severe asthmatics according to GINA step 4 classification
Tiotropium Bromide
A scopolamine derivative and CHOLINERGIC ANTAGONIST that functions as a BRONCHODILATOR AGENT. It is used in the treatment of CHRONIC OBSTRUCTIVE PULMONARY DISEASE.
Albuterol, Ipratropium Drug Combination
A combined pharmaceutical preparation of Ipratropium Bromide and Albuterol Sulfate that is used to treat the symptoms of ASTHMA and CHRONIC OBSTRUCTIVE PULMONARY DISEASE.
Cyanogen Bromide
Cyanogen bromide (CNBr). A compound used in molecular biology to digest some proteins and as a coupling reagent for phosphoroamidate or pyrophosphate internucleotide bonds in DNA duplexes.
An adrenergic beta-agonist used as a bronchodilator agent in asthma therapy.
Medication Therapy Management
Assistance in managing and monitoring drug therapy for patients receiving treatment for cancer or chronic conditions such as asthma and diabetes, consulting with patients and their families on the proper use of medication; conducting wellness and disease prevention programs to improve public health; overseeing medication use in a variety of settings.
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The term allergy is used to describe a response, within the body, to a substance, which is not necessarily harmful in itself, but results in an immune response and a reaction that causes symptoms and disease in a predisposed person, which in turn can cau...
Pulmonary relating to or associated with the lungs eg Asthma, chronic bronchitis, emphysema, COPD, Cystic Fibrosis, Influenza, Lung Cancer, Pneumonia, Pulmonary Arterial Hypertension, Sleep Disorders etc Follow and track Lung Cancer News ...
Asthma is caused by inflammation of small tubes, called bronchi, which carry air in and out of the lungs. If you have asthma, the bronchi will be inflamed and more sensitive than normal. When you come into contact with something that irritates your...
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text:
Sarri Stella
Since 2005, she has been working at the Hellenic American Union as an EFL teacher and examiner as well as an instructor of Modern Greek as a Second/Foreign Language. She is also involved in the development and editing of the Modern Greek language Blackboard e-learning platform.
Stella is currently working as an EFL teacher. She is also involved in the training of teachers of Modern Greek as a Second/Foreign Language, and, with a number of projects for the Center for Applied Linguistics and Language Studies specializing in Computer Assisted Language Learning, as well as teaching English online courses. Stella has also served as a member of the Executive Board of TESOL Greece.
Sarri, S. (2011). Teaching Modern Greek as a second/ foreign Language to Adults. Lambert Academic Publishing.
https://www.lap-publishing.com/catalog/details/store/us/book/978-3-8443-0476-3/teaching-modern-greek?search=MODERN GREEK
In this section:
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Where to find us
English Language Program
Μassalias 22
10680 Athens
Τel.: 2103680900, 2103680947, 2103680031
Fax: 2122222629
Email: email@example.com


text:
Each month, Rated People connects over 50,000 homeowners with quality tradesmen - simply enter your job details in the form above to get started.
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text:
What is JotForm?
JotForm is a free online form builder which helps you create online forms without writing a single line of code. No sign-up required.
At JotForm, we want to make sure that you're getting the online form builder help that you need. Our friendly customer support team is available 24/7.
We believe that if one user has a question, there could be more users who may have the same question. This is why many of our support forum threads are public and available to be searched and viewed. If you'd like help immediately, feel free to search for a similar question, or submit your question or concern.
Edit standard language for new forms.Asked by lauschmedia on February 10, 2014 at 01:14 PM
Hi my standard language for new forms is german.
Can I change it to English (US)?
JotForm Support
Hi, yes you can change it to English, at the bottom of the page you will see this:
Just to let you know, all forms previously created in german will stay the same, only the new ones to create, will be in English.
Please open a new thread if you have another questions, we will be glad to assist you.
Hi, I tried this already. As soon as I click on my forms the menu bar language switches back to german.
I've set my language settings in my account on english as well. But this does only affect the language in my account settings. Nothing else.
It countinues changing to german probably because you are using http://german.jotform.com/ or http://www.jotformeu.com/. Is that correct?
Please, try using this link to log in this time: http://www.jotform.co/
Then, make sure to set the page language to English as explained by my colleague.
I hope this helps. Please inform us if you need further assistance with this inquiry.


text:
Our Staff
Dr. Kim Riddlebarger, Senior Pastor
Dr. Kim Riddlebarger is senior pastor of Christ Reformed Church, and is co-host of the White Horse Inn radio program, which is broadcast weekly on more than fifty radio stations.
A fourth generation Californian, Kim is a graduate of California State University Fullerton (B.A.), Simon Greenleaf University (M.A.), Westminster Seminary California (M.A.R.), and Fuller Theological Seminary (Ph.D.) where he worked under Richard A. Muller.
Kim has served as a visiting lecturer in the graduate program in Reformation studies at Concordia University in Irvine, CA, and was the chairman of the Growing Reformed Churches Conference, cosponsored by First Chino URC and Westminster Seminary California, where he served as a member of the board of trustees. Kim also served as executive vice president of Christians United for Reformation (CURE), the forerunner of the Alliance of Confessing Evangelicals (ACE). Kim has also served several terms as visiting professor of systematic theology at Westminster Seminary California.
Dr. Riddlebarger is an ordained minister in the United Reformed Churches (URCNA), is a regular contributor to publications such as Modern Reformation and Table Talk and has written chapters for the books Power Religion (Moody), Roman Catholicism: Evangelicals Analyze What Unites and What Divides Us (Moody), and Christ the Lord (Baker), Theologia et Apologia (Wipf and Stock, 2006), Called to Serve (Reformed Fellowship, 2007), Risking the Truth (Christian Focus, 2009). Always Reforming: Essays in Honor of W. Robert Godfrey (2010), and Planting, Watering, Growing: Planting Confessionally Reformed Churches in the 21st Century (Reformation Heritage, 2011).
Kim is the author of four books: A Case For Amillennialism, (Baker Books, 2003/2013), and The Man of Sin: Uncovering the Truth About the Antichrist (Baker Books, 2006), First Corinthians: The Lectio Continua Expository New Testament Commentary (Tolle Lege Press, 2013); and The Lion of Princeton: B. B. Warfield as Apologist and Theologian (Lexham Press, January 2015).
Kim is married to Micki, and has two adult sons, David and Mark. He is interested in family history and is presently writing a history of the Riddlebarger family. Kim is also a life-long New York Yankees fan.
Rev. Andrew Compton, Associate Pastor
B.A. Dordt College
M. Div. Westminster Seminary California
M.A. University of California, Los Angeles
Rev. Andrew Compton is the associate pastor of Christ Reformed Church where he has served full-time since the Spring of 2012. His responsibilities center on pastoral care and counseling. In addition, he preaches during the summer months and teaches the weekly adult Sunday school class.
After graduating from Dordt College (Sioux Center, IA), Andrew taught high school band and orchestra in southern California. A budding interest in studying the Bible and Reformed theology, in addition to a growing desire to preach the gospel, drew him to enroll at Westminster Seminary in California (Escondido) where he earned his Masters of Divinity (M.Div) in 2007.
While studying at Westminster, Andrew became interested in Old Testament studies. Sensing that his Confessional Reformed tradition could benefit from a critical engagement with secular academic study of the Old Testament, he spent a year studying at the Claremont Graduate University (Claremont, CA) before transferring to the University of California, Los Angles. He earned his M.A. in Near Eastern Languages and Cultures in December of 2011. He has written reviews for the Calvin Theological Journal, the Westminster Theological Journal, and Themelios, and has contributed articles to the New Interpreters Dictionary of the Bible and the Lexham Bible Dictionary. He blogs with a fellow Reformed pastor on The Reformed Reader.
In addition to Old Testament studies, Andrew focuses on biblical counseling. He is currently pursuing his D.Min from Westminster Theological Seminary (Philadelphia) with a focus in pastoral counseling.
Andrew is an avid cyclist. When he is not engaged in ministerial work or out cycling himself, he can be found obsessively following professional cycling. He is also a trumpet player and enjoys playing and listening to classical music.
Andrew is married to Pamela, the organist at Christ Reformed Church, and together they have three daughters.
Pamela Compton, Church Organist
Pamela has a B.A. in Music Education from Dordt College (Sioux Center, IA), an M.M. in Sacred Music from the University of Southern California, and a D.M.A in Choral Music from the University of Southern California. Pamela has been a church organist for 19 years, the last 11 of which have been here at Christ Reformed Church in Anaheim.
Pamela's primary professional interest is in sacred music, particularly the Psalmody, hymnody, and liturgy of the Reformed tradition. She has a passion for accompanying congregational singing and enjoys making each hymn's distinct personality come alive by means of creative harmonizations and registrations. The most enjoyable and rewarding part of her job is hearing God's covenant people sing every week.
Music Education is also an area of great interest to Pamela. She taught K-5 general music for five years at Christian schools in Iowa and California. Currently she teaches piano and organ privately.
Pamela is married to Andrew, one of the ministers at Christ Reformed Church, and they are the parents of three young daughters.
Rev. Chris Coleman, Assistant Pastor
Rev. Chris Coleman has served as Assistant Pastor at Christ Reformed Church since October of 2011. Before that he served at Christ Reformed as the Sunday School teacher for the High School students from 2008-2011.
Born and raised in Orange County, Rev. Coleman became interested in Biblical Studies and Theology as an undergraduate student at Biola University (La Mirada, CA). It was during his studies at Biola that he was first exposed to the Theology of the Reformers and subsequently became a member at Christ Reformed Church.
After graduating with his B.A. in Biblical and Theological Studies from Biola, Rev. Coleman enrolled at Westminster Seminary California (Escondido, CA) to be trained as a Minister. During his time at Westminster, he became increasingly interested in Church History, especially the history surrounding the Three Forms of Unity. He also completed two summer internships, as a student at Westminster: first at Grace United Reformed Church in Kennewick, WA and second at Chiesa Riformata Filadelfia in Milan, Italy (a URCNA mission work in northern Italy). He graduated with a Masters of Divinity from Westminster Seminary California in 2011 and was ordained as Minister of Word and Sacrament in the United Reformed Churches in North America later that year.
Chris currently works full time in Commercial Real Estate, serving as administrative support to Sales Professionals with CBRE (the world's largest Real Estate company).
Chris lives in Los Angeles with his wife Melissa and their two girls: Clementine and Darla. They enjoy weekends out at the parks, farmers markets, beaches and other cultural activities that LA has to offer. Chris attempts to capture these family moments with his camera, a side hobby he also enjoys.
Mark and Ann Johnson, Choir Directors
Mark is Director of Music and conducts the Adult Choir. He is a graduate of California State University, Fullerton (B.A.-Music). Ann assists with Adult Choir and teaches hymnody to the children in Sunday School programs. Ann has degrees in Voice Performance from Biola University (B.M.) and California State University, Fullerton (M.M.). Having attended the church since its inception in 1995, Mark and Ann welcome this opportunity "to prepare God's people for works of service, so that the body of Christ may be built up…" (Eph. 4:12). Mark and Ann met at Christ Reformed Church in 1995 and were married by Pastor Kim Riddlebarger in 1998. They are the proud parents of Nathaniel, Katharina, and Gabrielle.
Winona Taylor, Secretary-Administrator
Miss Winona Taylor, AKA "Church Lady," is the secretary-administrator for Christ Reformed Church. For a number of years, Winona served as office manager at CURE, before the merger with ACE and the move to Philadelphia. She joined the church staff in 1997, and things have never been the same! Winona is the glue that holds everything together at Christ Reformed.
Current Elders
Eric Akiyoshi (Clerk of council), Paul Barr, Steve Irons, Ralph Kolbush, Mark Russell, Jeff Sikkema, Ed Silva, John Skocilic, and David Szucs
Current Deacons
Lane Chaplin (Chairman of the Deacons) Jack Daley, Thayne DeVorss, Jeff Gray, Henry Hernandez, George Perez, Robert Vasquez and John Woodward


text:
Washington, June 30: A ceasefire between Indias scientific community and diplomatic negotiators, painstakingly put together by national security adviser M.K. Narayanan at the time of President George W. Bushs visit to India, is under strain following attempts in the US legislation to shift the goalposts on the nuclear deal.
Behind closed doors on Raisina Hill, the two sides have started blaming each other for having made Indias nuclear weapons programme vulnerable to this weeks developments on Capitol Hill.
At the heart of the carping is Section 3(b)(1) and (2) of HR 5682, the bill marked up by the House of Representatives International Relations Committee this week for a July vote by the full House.
These portions of the bill under the head Statements of Policy call for achieving a moratorium on the production of fissile material for nuclear explosive purposes by India, Pakistan and the Peoples Republic of China at the earliest possible date.
They also call for facilitating at the earliest possible date the conclusion of a Fissile Material Cutoff Treaty (FMCT) to which both the US and India become parties.
The foreign ministry is putting out the spin that these and similar sections of the bill are not binding, but Indias informed nuclear establishment is finding it hard to swallow.
It has pointed out that while these clauses may be non-binding, Washington is certain to push for a moratorium on fissile material production by Asias nuclear powers and for an early FMCT.
Indeed, it is bound to do so because the bill insists that these shall be the policies of the US.
The bill, its critics within the Indian establishment point out, has made it US policy that the US and India become parties to an FMCT, denying Delhi the option to stay out of the treaty unlike in the instance of the Comprehensive Test Ban Treaty.
Indias foreign policy mandarins have reacted with venom to such suggestions, accusing the nuclear establishment of not having produced enough weapons-grade plutonium and stockpiled it while it had the luxury of doing so without any restrictions or external oversight. One senior diplomat went so far as to say that because of this drift, India does not even have a credible minimum nuclear deterrent as of now.
There is considerable anxiety within South Block itself that three new elements have been brought into nuclear negotiations by the US.
Although non-binding at present, the most serious of these is Washingtons determination to see India join its Proliferation Security Initiative. Hypothetically, it could require India, for instance, to interdict and board a Chinese ship carrying missile parts to Pakistan. A potential clash with China at Americas behest is not something anyone in South Block relishes.


text:
Big beautiful in the Historical Willo District with Guest House! Over 2400 sq ft of living area- 3 bedroom, 2 bathroom light and bright open concept main house with studio guest house in backyard. This top to bottom remodel with permitted addition brings you all the modern conveniences in one of Phoenix's most sought after historic districts. Relax and enjoy the lush grassy backyard with RV gate for easy guest house access. Upgraded appliances, wood tile, slide in range and farmhouse sink, and custom glass cabinets in kitchen are some of the designer features. Master suite has His and Hers closet and is beautifully appointed in custom finishes. Guest house has kitchenette and bathroom. This is a gorgeous home come fall in love today!
Basic Features
Advanced Features
Zoning Info
Area Info
Contact - Listing ID 5645639


text:
On a recent episode of his show on MSNBC, host Thomas Roberts brought Len Everett on as his guest. The topic was Duck Dynasty's new gun line.
Everett is with the Coalition to Stop Gun Violence. He made the outrageous claim that Phil Robertson is launching the new gun line as a way to market guns to conservative, middle-aged, white males.
So in otherwords, Phil Robertson has now been demonized by the left for finding a profitable way of expanding his multi-million dollar hunting empire. And in the typical tradition of MSNBC hosts and their guests, they managed to find a way to pull racially divisive rhetoric into the news of this product launch.
From the show's transcript. Everett warms up with this statement:
Well, look, I mean I think the Robertson family is banking on being able to market firearms, you know, by issuing some of these very extreme political comments and hoping that it appeals to basically a swath of far right-wing Americans that they assume are their main customer base. I'm hoping that backfires. When you poll gun owners in this country, the fact is that the overwhelming majority of them are very moderate in their views. And I think many of them will not embrace the type of, you know, misogynist, racist, anti-gay comments that Phil Robertson is making.
After the anti-gun Everett gets done lecturing MSNBC's audience on the personal views of gun owners, he makes his best attempt at eliciting controversy over a VERY non-controversal product expansion from a popular company.
"I think sadly every day more people are being pulled into this conversation because they're losing loved ones or they're being injured and their lives are being catastrophically affected. In terms of the dynamics of mass shootings, you mentioned semiautomatic firearms being used. The other very common element here obviously is high capacity ammunition magazines, and of course that ties into the Duck Dynasty story where they have now decided in addition to traditional hunting firearms, to also try to market some semi—automatic firearms that accept 25-round magazines which is obviously not necessary for plinking around your house."
The MSNBC host then responded:
"No. Or for taking down a duck but that's a different story."
We are relieved to know that MSNBC's Thomas Roberts is now an expert on proper duck hunting weaponry.


text: 4. As of noon trading, Delta Air Lines ( DAL) is down $0.49 (-2.5%) to $19.34 on light volume. Thus far, 3.7 million shares of Delta Air Lines exchanged hands as compared to its average daily volume of 10.3 million shares. The stock has ranged in price between $19.29-$19.79 after having opened the day at $19.77 as compared to the previous trading day's close of $19.83. Delta Air Lines, Inc. provides scheduled air transportation for passengers and cargo in the United States and internationally. Its route network is centered around a system of hub and international gateway airports in Amsterdam, Atlanta, Cincinnati, Detroit, Memphis, Minneapolis-St. Delta Air Lines has a market cap of $16.7 billion and is part of the transportation industry. Shares are up 67.1% year to date as of the close of trading on Friday. Currently there are 7 analysts that rate Delta Air Lines a buy, no analysts rate it a sell, and 2 rate it a hold. TheStreet Ratings rates Delta Air Lines as a buy. The company's strengths can be seen in multiple areas, such as its solid stock price performance, impressive record of earnings per share growth, compelling growth in net income and good cash flow from operations. We feel these strengths outweigh the fact that the company shows low profit margins. Get the full Delta Air Lines Ratings Report now. STOCKS TO BUY: TheStreet Quant Ratings has identified a handful of stocks that can potentially TRIPLE in the next 12-months. Learn more.


text:
What is JotForm?
JotForm is a free online form builder which helps you create online forms without writing a single line of code. No sign-up required.
At JotForm, we want to make sure that you're getting the online form builder help that you need. Our friendly customer support team is available 24/7.
We believe that if one user has a question, there could be more users who may have the same question. This is why many of our support forum threads are public and available to be searched and viewed. If you'd like help immediately, feel free to search for a similar question, or submit your question or concern.
Why Form is taking too much time to upload and why it showing different behavior in different browser ? Its Very urgent .Asked by Atulbhandari on November 14, 2013 at 02:11 AM
When I uplaod my pages and click on apply button then my forms are taken too much time to uplaod and its showing different behavior in in different browser. MY forms url are
JotForm Support
Hi there,
Your form appears to be fine on my Chrome and Firefox. I checked it on different IE browsers as well even on IE7 and it seems to be fine.
I have also submitted a test submission and everything runs smoothly. It submits the form almost instant. You can check my video test here: http://screencast.com/t/Wid4O4vrRt
May I suggest you please clear your browsers cache and cookies and recheck again the form. So far your form works perfectly fine on my end.
Thank you!
Hay I saw your Video Form is already opened.... My Problem is once you click on apply button then it takes time to show the form. And I am sending you some screen shots on different browser.
In the screen shots
you can see the form height is different in diff. browser and in IE the field box shadow is disapear why ?
Upon checking your form we are unable to see a massive delay upon clicking "Apply now" on your Website/page.
I have tested using Internet Explorer and Google Chrome. Both with the same look and working that same behavior.
I have cleared your form caches, please try to clear your browser cache and cookies and check if this could help fix the issue your are experiencing on your end.
This might be due to network speed also.
If problem persist please let us know so that we could further check.
Thank you.


text:
On 12/13/12 08:01, Hu Tao wrote:
This is merely a rebased version, so still tagged with v1. The reason to disable cgroup cpuset by default is: currently, sub-directories of cgroup cpuset won't be auto-updated if cpu hot-plug happens. For example, if we now have 0-3,5-7 pcpus online, the value of /sys/fs/cgroup/cpuset/libvirt/qemu/mydom/cpuset.cpus is 0-3,5-7, then pcpu 4 is hot-plugged, but the value of cpuset.cpus is still 0-3,5-7. This will cause a problem that we can't pin to a hot-plugged pcpu. Users can still enable cpuset by editing qemu.conf.
CPU hotplug isn't really a common thing in hosts right now. I'd rather go for cpusets enabled by default and disabling them only if it poses problems.


text:
|Message view
|« Date » · « Thread »
|« Date » · « Thread »
|Grzegorz Kossakowski <g...@tuffmail.com>
|Re: Cocoon-jms-sample requires Java >= 1.5
|Wed, 30 Jul 2008 13:38:01 GMT
Reinhard Pötz pisze: > Now we have the problem that the ActiveMQ version that we use was built > with Java 5: <snip/> > According to > http://activemq.apache.org/can-i-use-activemq-5x-or-later-on-java-14.html > there is no version built for 1.4. > > What shall we do? Actually, this is a part of bigger picture. Let me explain. Due to refactorings in Servlet Service Framework and Spring Configurator (thanks Reinhard for doing that!) they are not back compatible anymore so we will need to release 2.0.0 of both projects. Now Cocoon Core (of version 2.2.0) depends on these projects so Core itself becomes not back compatible anymore. Therefore we'll need to release 2.3.0 of Cocoon Core to keep things clean. Then, if we are going to release 2.3.0 I think it's valid to bump Java version requirement. Especially if you look at this message from Sun: J2SE 1.4.2 is in its Java Technology End of Life (EOL) transition period. The EOL transition period began Dec, 11 2006 and will complete October 30th, 2008, when J2SE 1.4.2 will have reached its End of Service Life (EOSL). [...] Customers interested in continuing to receive critical fixes, are encouraged to consider the following options: * Migrate to the latest Java SE release * Migrate to Java SE for Business 1.4.2 (the source: http://java.sun.com/j2se/1.4.2/download.html) Then I think the solution is rather clear: we need to migrate to 1.5. If Sun is not supporting Java 1.4 then I don't want to support it as well in our _trunk_. People that need to stick to Java 1.4 still have a choice: We have released 2.2 that works with Java 1.4. Therefore I propose to switch to 1.5 and focus on getting real work done. WDYT? -- Grzegorz Kossakowski
|View raw message


text:
Posts Tagged 'sports'
Esports in Hong Kong — More Than Just Entertainment
People who play video games professionally are taking advantage of the growing industry in China, Taiwan, and elsewhere in the world, but aspiring pro-gamers in Hong Kong are having trouble catching up to their peers.
Camping on the Wild Side
Hong Kong has designated campsites, but some campers prefer to live on the edge and go beyond official site in pursuit of nature.
The Wrong Mix
Each district has its own sports and recreational facilities, but what they have may not be what they need. Districts with ageing population don't have much for the elderly, whereas others have gateball courts that are only used 40 per cent of the time.
Run with the City
More and more people are taking to running in Hong Kong and they're doing it to meet friends and experience Hong Kong's neighbourhoods, not just to keep fit.
Fly High
Paragliding lets you get a birds-eye view of Hong Kong by flying up with the birds.


text:
Is Okay To Give My 4 Month Old Daughter Water In Her Bottler Every Once In Awhile?
Started by Melissa on 04/13/2010 in Welcome To Circle Of Moms!!
Last update on 04/18/2010 by Lisa
Is Okay To Give My 4 Month Old Daughter Water In Her Bottler Every Once In Awhile?
Last update on 04/18/2010 by Lisa
My 7 month old daughter is so gassy, it doesn't matter what I feed her or what I don't feed her, and she has been since birth. It wakes her up at night, she gets very restless...
Last update on 12/08/2011 by Hayley
Getting a alot of mixed messages about soy vs regular formula... my one month old is on simulac advance with iron, but seems to be very grumpy while eating and very very gassy...
Last update on 12/12/2008 by Nicole
Last update on 08/31/2013 by Kyrie
Last update on 03/21/2013 by SHAYNA
My 6-week-old breastfed baby is having problems with gas. She is spitting up alot so I have cut out of my diet caffeine, dairy, and gas-causing foods such as onions. I have...
Last update on 01/26/2009 by Heather
My son is a constipated baby and has been since he was born. He slept thru the night at 8 weeks til about 10 weeks ago. He wakes up every night with gas pains and won't go back...
Last update on 04/04/2014 by Claudia
I'm a new mom &my son who is a month old has gas problems (which he has had since he was born). i just changed his formula almost 2 weeks ago,to emfamil gentlease & just...
Last update on 02/28/2016 by Sara
My 2 month old was sleeping through the night except waking one to feed but the last week he has not been pooping an ha been in pain and now wont sleep much,no more then 4 hours...
Last update on 05/26/2010 by Tracey
I think my baby could be constipated. It really seems to hurt him when he poops. I was wondering if giving him water would help.
Last update on 05/25/2011 by Crystal
My daughter is 2mo and has terrible gas that causes her to scream. I've tried mylicon and it hasn't helped. She is breastfed and i have yet to figure any specific foods that...
Last update on 01/02/2010 by Cynthia
Last update on 12/30/2011 by Shannintipton
Last update on 03/23/2016 by Amanda
Last update on 11/12/2009 by Rachel
It wakes her up, she farts really loud, it is getting unbearable. I have burped her a million times, used infants friend, infacol and herbal solutions that just do not seem to...
Last update on 10/02/2009 by Andrea
My water broke at 23 wks, and I was in the hospital for 6 wks until they had to deliver my baby girl at 29 wks. I was just wondering how long it was for all the other special...
Last update on 01/29/2017 by Jayme
daughter is almost 4 weeks old. doesn't seem to have lower gas, but gets very uncomfortable after feedings. She tenses up, and burps alot... which are often followed up by...
Last update on 12/16/2008 by User
Last update on 02/28/2016 by Sara
Is the water breaking a little drizzle or does it always have to be a big gush? Also does it ever have any blood in it?
Last update on 02/26/2012 by Leslie
My baby is 6 weeks and hass gas trouble please help
Last update on 01/04/2014 by Annie


text:
Southern California High Tech Event Calendar
|View By:
|View By:
|Game Developers Conference Next (GDC Next)
|Date: November 03, 2014
|Location:Los Angeles
|Game Developers Conference Next (GDC Next). GDC Next answers the question: "So you've made a game, what's next?" GDC Next brings the video game community together – from makers to marketers, from companies both big and small – to learn how to increase discoverability, gain exposure, broaden their audience, differentiate their work, and position their games for industry success. See http://www.gdcnext.com
|More information: http://www.gdcnext.com
|Download to Calendar


text:
Every Full-Size Pickup Truck Ranked from Worst to Best
Where You'll Find Her: In Paper Towns, out June 4.
Despite their gazelle-like physiques, supermodels often wind up looking like jackasses when they attempt the leap from posing to acting. But Delevingne's starring turn in this summer's adaptation of a John Green YA novel (this one's 100% cancer-free!) is an exception: she's already gaining notices as a model ingenue.
Where You'll Find Her: In Dope, out June 19.
The only daughter of Lenny "Cinna from The Hunger Games" Kravitz and Lisa "Denise Huxtable" Bonet has been knocking around in small parts for years; she finally lands her first big gig in this Inglewood-set, coming-of-age comedy as a teenage nerd's crush. Get in line, dude.
The 9 Most Common Misconceptions About Hammers


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The events in Colony Crisis Averted affected the world of sports in many ways, profoundly in America and Europe.
Difference from OTL
Due to what would have been the United States is still with the British Empire, American influences on British/European sport culture is high. Baseball, basketball and American football are more popular across the world because of heavy American influence, unknowingly spread around the globe by the British. The American franchise system is used most then the promotion and relegation model for basketball and American football leagues.
- Baseball quickly became famous globally by the 1870s due to the British soldiers playing the games across the Empire and the major advertisement for the sport by British radio broadcasters. Baseball leagues begin roaming across British Empire, Europe, Japan, Africa, and some South American viceroyalties. After the South American Wars, professional leagues were founded in many Latin American viceroyalties, most prominently Venezuela (1886) and the Cuba (1885).
- With slavery being abolished in 1833 and the British being more culturally diverse by the mid 1800s, black people become integrated earlier into sports then OTL, which also helps the popularity of baseball to grow in Africa.
- Baseball became the North American Union first official sport in 1890.
- Major League Baseball is known as the National Baseball League.
- NBL is still divided into the American and National Leagues, but both leagues have four divisions and 32 teams in total with teams such as Montreal Expos and the Brooklyn Blues.
- The Cleveland Indians win the 1954 (the infamous "The Catch" never happen) and 1994 World Series.
- The National Basketball Association is known as the American Basketball Association, divided forty-eight teams into two conferences of four divisions with six teams each.
- Len Bias doesn't overdose on cocaine, leads the Boston Celtics to victory in the 1987 ABA Finals and rivalry between him and Michael Jordan is created after upsetting the Bulls in the 1994 ECF and going on to win the ABA Finals.
- With Len Bias challenging his ABA supremacy and without the death of his father, Jordan doesn't retired and play baseball but continues to play with the Astoria Bulls.
Lebron James stays in Cleveland and a Cavaliers ABA Finals victory
On June 30, 2010, Stoudemire opted out of his contract with the Phoenix Suns, which made him an unrestricted free agent. On July 5, 2010, Stoudemire and the Cleveland Cavaliers agreed in principle to a contract estimated to be worth around $99.7 million over five years. On the first day that free agents were allowed to officially sign, the Cavaliers formally introduced Stoudemire at Quicken Loans Arena. There Stoudemire proclaimed "the Cavs are back!" referring to the team's lack of playoff success the past few years. On July 8, 2010, LeBron James held an hour-long special to announce his decision on ESPN to commit to playing with the Cavaliers. On February 22, 2011 the Cavs made a three-team trade with the Detroit Pistons and Minnesota Timberwolves that sent Pistons superstar Carmelo Anthony to the Cavaliers along with the Nuggets' starting point guard Chauncey Billups.
Spurned and unable to convince his friend LeBron to take his talents to South Beach, Dwyane Wade opts to return to his native Astoria. He teams with fellow Astoria native and young, ascendant MVP Derrick Rose to best LeBron's Cavs in a seven-game series for the ages in the 2011 Eastern Conference Finals. The city's favorite sons — aka the most dynamic backcourt in league history — bring the Larry O'Brien Trophy back to the Windy City for the first time since the Jordan era.
Having the worst team record in the 2010–11 season, the Knicks had high odds of winning an early draft pick in the NBA Draft Lottery, with a 22.7% chance of their pick becoming number one overall. The Knicks took Duke Blue Devils guard Kyrie Irving with the first pick.
Ray Allen realizes the aging Celtics' Big Three doesn't have the weapons to battle with the Cavs' Big Three and the Bulls' Rose-Wade tandem. He decides to sign with the always-contending Spurs as a gun for hire. He ends up earning 2012 Finals MVP honors. His signature moment is the series-clinching corner three over a late-rotating 'Melo in the final seconds of Game 6. Two years in, the Cleveland super squad is still without a championship. And the wait is over. With a Finals performance for the ages, LeBron delivers Cleveland its first sports championship since 1964 as the Cavs turned back the New Liverpool Lakers. The trio of Kobe Bryant, Chris Paul and Dwight Howard wasn't enough to deny LeBron & Melo their first championship.
Chris Paul is traded to the Lakers. The American Basketball Players' Association threatens legal action against David Stern's vetoing of the Lakers' trade for Chris Paul. The league and owners relent. CP3 joins Kobe and later Dwight Howard for yet another Big Three. Howard clashes with the league's two most demanding personalities, but not before all three sign extensions to ensure years of deep playoff runs and gossip-mill churning. On June 25, 2013, the New Liverpool Lakers acquired Doc Rivers from the Celtics for an unprotected 2015 NBA first round draft pick. He also became the Senior Vice President of Basketball Operations on the team. With Goran Dragic, Lamar Odom, Kevin Martin, and Luis Scola on the team, the New Orleans Hornets go 40-26 during the 2011-2012 season. On May 30, 2012, the Bobcats were awarded the first overall pick in the 2012 NBA draft and subsequently drafted Anthony Davis. On July 11, 2012, the Toronto Raptors acquired Nash in a sign-and-trade deal with Phoenix. Nash also considered signing with New York or New Liverpool, but he decided that Toronto was the best fit for him and his family.
American football
- The National Football League is know as the American Football League.
- The AFL is composed of 64 teams divided equally between the Premier Football Conference (PFC) Canadian Football Conference (CFC), National Football Conference (NFC), and the American Football Conference (AFC).
- American football is extremely popular in the Americas and Europe by the 1990s, with Brazil, Germany, Russia, and other international leagues being formed.
- American football is accepted by the Olympics Committee in 2005.
- John Elway and the Denver Broncos are stalled at the one-yard line by the Cleveland Browns and go on to lose in the 1987 AFC Championship Game. The Browns advance to Super Bowl XXI against Bill Parcell's New York Giants. Down by one and backed up at their own one-yard line, Bernie Kosar leads the Browns in a 99-yard drive, ending with a five-yard pass to Ozzie Newsome. This will forever be known as The Drive and Cleveland Browns will go on to win their first ever Super Bowl.
- Cleveland Browns once again goes on to win the AFC Championship Game in 1988 against the Broncos as the Browns rallied in fumble free run by Ernest Byner. They advance to their second straight Super Bowl but lose to the Victoria Redskins.
- Without the three straight Super Bowl appearances, John Elway is traded to Green Bay in 1991. His annual postseason duels against Troy Aikman and Steve Young elevates him to all-time great and two-time champion in 1996 and 1997, who he led the Packers past Brett Favre's Denver Broncos.
The Detroit Lions traded Barry Sanders & a Dan Marino Super Bowl victory.
- After an intense bidding war, Sanders is traded to NFC Central rival Tampa Bay in exchange for young running back Warrick Dunn, safety Dexter Jackson, and first and fifth round picks in the 2000 AFL Draft. Though initially reluctant to join a team that hadn't made the playoffs in the previous season, Sanders eventually embraces his young teammates and resolves to lead them to the Super Bowl. Before the 2000 season, Dan Marino decided to accept the Tampa Bay offer when the Dolphins declined his option on his contract in hopes of finally winning a Super Bowl. The '02 season becomes a war between Tampa Bay and the upstart Philadelphia Eagles for NFC supremacy. Both came into Week 16 with identical 12–2 records, but Tampa Bay manages to steal home-field advantage after the Eagles are shocked by 5–11 Cowboys and then lose to the New York Giants in Week 17. This makes all of the difference, as each win tough games in the divisional round to set up a long-awaited NFC championship game in Tampa Bay.
- The game plays right into Tampa's hands as its stingy defense holds the Eagles to only six points through the first three and a half quarters. Quarterback Donovan McNabb leads a drive down the field late in the game hoping to take the lead, but the raucous Tampa crowd makes it so hard for him to relay signals to his receivers that he is picked off by John Lynch on a miscommunication between him and receiver Na Brown. Three plays later, the Bucs seal the win on a touchdown pass from quarterback Dan Marino to Sanders. Tampa Bay is headed to the Super Bowl.
- The heavily favored Raiders take an early lead, but with the Tampa defense is once again in top form, led by a Super Bowl record 209 rushing yards by Barry Sanders, Marino simply won't be denied. In one of the most iconic plays in AFL history, he dives across the 20-yard line for a first down while being hit on both ends by Raiders defenders in a play later dubbed "the helicopter dive." The Buccaneers win in the closing minutes, the Tampa Bay Buccaneers win their first ever Super Bowl title and giving Marino his first ring.
Buffalo Bills' two straight Super Bowl victories leads to Dallas Cowboys four-peat Super Bowl wins.
- Scott Norwood makes the 47-yard field goal at the end of Super Bowl XXV against the New York Giants, and the Buffalo Bills win their first title since 1964. Emboldened by the Super Bowl victory, the Bills go back to back narrow win against Mark Rypien and the Washington Redskins their victory in Super Bowl XXVI.
- Bills advance to Super Bowl XXVII, but are defeated by the Dallas Cowboys who pull the upset against the two-time champions. In the game's most memorable play, defensive lineman Leon Lett's fumble return made the final score of 61-17, and the Cowboys topped the previous Super Bowl record of 55 points scored in a game that the 49ers had set three years prior.
- The Buffalo Bills and Dallas Cowboys meet again in Super Bowl XXVIII, but the Bills are again defeated, ending their the four year appearance in the Super Bowl. The Johnson-Turner duo thrives once again, and after a 14–2 regular season the Cowboys waltz through the NFC playoffs and reach the Super Bowl against Kansas City. The Chiefs keep it close for much of the first half, but the Cowboys pull away in the second half to win 52–49. They go on to Super Bowl XXIX after defeating the 49ers three straight times in the NFC Title Game. Troy Aikman threw a Super Bowl-record six touchdown passes en route to the Super Bowl MVP award, while obtaining their third-straight Super Bowl victory. A year later, Dallas defeats the Cleveland Browns in Super Bowl XXX, giving them four straight championships and being named the best team ever. After three consecutive championships and with a still-strained relationship with Jones, Johnson vows to never again coach in the NFL and returns to the University of Miami to continue where he left off.
Carson Palmer leads the Bengals to Super Bowl XL and a Wellesley Seahawks' championship.
- On January 8, 2006, the Cincinnati Bengals took on the Pittsburgh Steelers in the opening round of the playoffs making it the Bengals' first playoff appearance of the decade. Disaster started early for the Steelers when Bengals' quarterback Carson Palmer dodges Steelers' lineman Kimo von Oelhoffen, resulting in a Hail Mary pass to Chad Johnson giving Cincinnati the lead of 10–0. All seemed well for the Bengals, who scored 24 unanswered points and knocked the Pittsburgh Steelers out of the playoffs with a final score of 34–7. The Bengals go on to defeat Jake Plummer Broncos and face the top-seeded Indianapolis Colts in the AFC Championship game. Peyton Manning leads the Colts down field after withstanding Cincinnati fourth-quarter comeback, but Edgerrin James' fumble at the goal line is recovered by Bengals corner Deltha O'Neal for a touchdown. Cincinnati go to Super Bowl XL and face the Wellesley Seahawks. At the end, Mike Holmgren holds the Lombardi Trophy, Seahawks' Shaun Alexander is named Super Bowl MVP and Cincinnati Bengals dominate the AFC North for years to come.
Joe Flacco's failed "Hail Mary" leads to Drakestown 4th Super Bowl win.
- Joe Flacco's playoff Hail Mary against the Broncos fell flat helped propel the Broncos to the AFC title game against New England. Both teams enter the fourth quarter scoreless, until Peyton Manning throws for a 30-yard touchdown to Demaryius Thomas. Tom Brady led the Patriots in a 50-yard drive to tied it at 7-all. Tied at 7-7 for four quarters, both teams entered into OT. Peyton Manning throws an interception and Tom Brady finished the game with a ten-yard reception to Wes Welker. The Patriots and Drakestown meet in New Orleans, but the 49ers offense-led Colin Kaepernick proves too much for New England's defense. With being sacked nine times and two interceptions, Tom Brady's struggle gives Drakestown 49ers their fourth Lombardi Trophy.


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By:Christopher Eger | Jul 24th 2013
One gun that every serious gun owner should have in his or her collection is a small caliber suppressed firearm. While there are many entry level silenced plinkers out there on the market today. One of the better choices ... 0
By:Austin McLendon | Dec 22nd 2011
We recently acquired a Walther p22, I was a bit concerned about it from what I had read on the internet but knew to take that with a grain of salt. After firing around 250 rounds through it, it hasn't had a single failure ... 5


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5 Irresistible Energy Balls
We have gathered a few of our favourite no-bake energy balls, which are the perfect fuel for on the go. The best part: they can be stored up to a week in the fridge!
Whilst we are all waiting for the infamous pumpkin lattes to return, these pumpkin energy bites will help us pass the time. These are also suitable for those with nut allergies, as they mainly include pumpkin puree, seeds, dates and rolled oats. They also provide a great dose of vitamin A, zinc and fiber.
With blueberries having one of the highest antioxidant capacities and cashew nuts having monounsaturated heart-healthy fats, these energy bites will boost your cardiovascular health. For final touches, you can add coconut shreds and lemon zest.
Since it is summer we had to include these energy bites. Due to the added hemp they are filled with plenty of protein and fiber. The mix of mango, coconut and nuts will easily make these one of your favourites.
If you cannot get enough of coffee, we got you covered. Completed with oatmeal, almond butter and chocolate chips it is a great pick-me up if you are lacking energy or have a sweet-tooth.
These vanilla plum bites are amazing, both in terms of nutrition and taste. They contain a good amount of potassium, fiber and sorbitol and the subtle vanilla hint (you can always add more for a stronger one) make them truly delicious.


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Airbus to support UK's Atlas A400M
The UK Ministry of Defence (MoD) has negotiated a £410 million contract with Airbus Defence and Space to provide in-service support for the Royal Air Force's (RAF) A400M Atlas fleet until 2026.
The contract covers maintenance, upgrade and repair of the UK's entire fleet of Atlas transport planes, and is expected to sustain around 200 UK jobs with Airbus Defence and Space, focused around RAF Brize Norton in Oxfordshire.
Air Marshal Julian Young, Chief of Materiel (Air) at the MoD's Defence Equipment and Support organisation, said: 'The A400M Atlas will form the backbone of the RAF's strategic and tactical air transport capability over the next decade and beyond.
'This key contract will deliver maintenance for our A400M Atlas fleet, enabling this class-leading aircraft to support UK military operations around the globe.'
The RAF currently has 14 Atlas aircraft in service, with the planned fleet of 22 scheduled to enter service by 2019.
A new hangar facility worth around £62 million is on schedule to be fully fitted-out at RAF Brize Norton by early 2017. The building will be capable of housing three Atlas aircraft during maintenance periods.
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A MAN is facing a trial on three reckless arson charges.
Ian Naismith denied the charges when he made a brief appearance at Chelmsford Crown Court on Monday February 17 and the case was adjourned until April.
Naismith, 48, Rutland Road, Chelmsford, was granted bail until then.
He denies destroying a shed and contents, a fence panel and trampoline worth £300, a dog kennel, workshop and tools worth £2,760.
The alleged incidents took place on June 5 last year at other addresses in Rutland Road, the court heard.


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Small Engine
Small Engine Troubleshooting Problems? Ask a Mechanic Now.
You are most likely right, these transmissions have a tendency to burn out after a while.
You can pick up a new transmission from a honda dealer, part number 20001-VG4-H02 It will cost you about $110. These transmissions are not rebuildable, and have no serviceable parts
Remove the spring that holds the belt tight on the transmission then remove the belt and roll the transmission forward. Remove the pulley and cables (the pulley is held on by a roll pin) remove the wheels, and the e-clips that hold the gears on, remove the gears, keys and springs. There will be another e-clip underneath the gear, that needs to be removed as well.On the inside of the deck is one more e-clip that needs to be removed. the transmission can now be slid out of the mower. Reinstall is the same in reverse.
As simple as this job sounds it is not an easy job and unless you feel very comfortable with it then I would suggest that you have a shop do it for you. It should not take a shop more then an hour to complete this.
How do I get that spring off. Does the spring need to come off before I can get the belt off? The belt seems to be tight but could it be possible that just the belt needs replacing? The mower is 10 years old. Your answer to these questions should complete all my questions. Like I said the mower will work some but the drive gets very slow after about 30 minutes.
Thank you
Your symptoms are exactly the norm for these transmissions. 10 years is a very good length of time for them. There are some fiber clutches inside the transmission that when worn will work when cold and slowly decrease as they warn up. If the belt is tight then it probably does not need to be replaced. Once they stretch they get some slack in them and it is fairly obvious they need replacing.
The easiest way to remove that spring is with a long screwdriver or pry bar. It takes some muscle, but it will pry up and over the top of the bar that holds the transmission belt tight. Yes the spring needs to come off before you remove the belt, unless you cut the belt off.
One more.
Do I need to undo the bolt that puts the tension on the spring. It appears there is a nut that I have to hold while turning the bolt head I think is a 10mm
There are no bolts that hold that spring in place. See #4 in the picture, it attached to the rear of the deck by #2 and slips over the big S piece in the front of the transmission.
I apologize you are right, trying to work too fast while I am at work I guess. Yes that bolt needs to come out. Here is "your" transmission.


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Who is it for?
- All skin conditions
What is it?
- It's skin health for the entire body: to go! If you're a first-time Dermalogica user, then prepare yourself for great skin! If you're already hooked, then you'll love this convenient kit that contains travel-friendly sizes of your Dermalogica favorites, including Conditioning Body Wash, Body Hydrating Cream, Exfoliating Body Scrub and Climate Control Lip Treatment
- Use your Body Therapy Skin Kit morning and night, or as prescribed by your professional skin therapist
The Kit Contains:
- Conditioning Body Wash (2.5 oz)
- Exfoliating Body Scrub (0.75 oz)
- Body Hydrating Cream (2.5 oz)
- HydroActive Mineral Salts (sample)
- Climate Control Lip Treatment (0.15 oz)
- Pre cleanse ( sample )
- Shine Therapy Shampoo (sample)
- Silk Finish Conditioner (sample)


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Clock Changes in Callao, Callao, Peru
Daylight Saving Time (DST) Not Observed in Year 2017
Callao currently observes Peru Time (PET) all year.
DST is no longer in use.
Clocks do not change in Callao, Peru.
The previous DST change in Callao was on March 31, 1994.
Try selecting a different year below.
Daylight Saving Time in Other Years
DST changes do not necessarily occur on the same date every year.
|DST End (Clock Backward)
|DST Start (Clock Forward)
|2010 — 2019
|DST not observed
|All times are local for Callao. Current year is highlighted.
Data for the years before 1970 is not available for Callao, however, we have earlier time zone history for Lima available.


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Tata renames Zica hatchback ahead of postponed launch
Tata Motors has renamed the small-hatchback-originally-to-be-called-Zica following a social media quest for a new nameplate that could not be easily linked to the current Zika virus epidemic.
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This guy likes me and has liked me for about six months and nothing happened yet, is he after sex or a relationship?
Most Helpful Girl
I don't think it's like a guy would be in a consistent relationship with you for six months if he only wanted sex
And by consistent I mean, no games. Like you've gotta be sure he adores you and you're the only girl to him. If you've ever had to wonder or feel insecure about him that's a sign he may not be the one
Also watch his character. How does he treat people behind their backs? Who is he to people who can't do anything to benefit him? Is he a good kind person?00|00|0
We're not dating yet, more like crushing for six months. Do you think he would wait this long to go out with me if it's just about sex or does he really like me?
- Show AllShow Less
Oh ok. Well why not date him then?
I'm shy... he's shy... and i'm not sure if he's only looking for sex or a relationship, I need to be sure of that first.


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By providing generous and thoughtful philanthropic support, the past and present generations of Foulkeways have helped to safeguard "The Spirit of Foulkeways" legacy.
Click on a link below to learn more about Foulkeways' donors.
Beaumont House Gardens
50 Trees for 50 Years
George and Barbara Patterson
Gus and Rita Beck
Bob and Hannah Snyder


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Thanksgiving Deep Creek Lake gatherings are a favorite among our guests. Getting together with your favorite people surrounded by gorgeous scenery makes the holiday even more special.
Whether you are having a large get-together or something more intimate, we have a few tips to help you plan your Thanksgiving Deep Creek Lake escape:
–Plan early. This is especially true if you are bringing a group with ten or more people. We have a wide variety of Deep Creek Lake vacation rentals, but the early bird gets the exact location, bed sizes and amenities that they prefer.
–Take the stress out of preparing a big meal. Arrowhead Market prepares homemade holiday dinners with all of the traditional Thanksgiving dishes. Be sure to give them a call and place your order in advance.
At Ace's Run you can choose from Turkey Dinner [$19.95] or an Open Kitchen theme – PastaNight or Stir-Fryday [$18.00] and Dessert Specials [$5.95].
Wisp Resort offers a complete Turkey Day dinner package that serves 15-20 people.
The Thanksgiving Buffet at Penn Alps Restaurant & Craft Shop is an all-you-can-eat affair, so no worries about going home hungry!
Harvest Moon Catering is happy to do the cooking for your feast. They have organic and gluten free options available upon request. Order by November 20 for pick-up or delivery.
–Treat yourself with some Thankgiving sweets. Trader's Coffee House has a lot more than just java. From pies to rolls, you can order up all things pumpkin plus a lot more!
–Shop local for the December holiday. Visit the Festival of Trees November 25 or 26 at the Garrett County Fairgrounds to have breakfast with Santa or to shop for unique items from local and regional artisans. Beautifully decorated trees will be auctioned off as the grand finale of this fun event.
Head to downtown Oakland to browse the area's best antique stores.
I also suggest taking a short drive to Grantsville's "Little Crossings" area where you can shop at Grant's Mercantile and grab a snack at Cornucopia Cafe. Plus, you can check out Casselman River Bridge State Park.
–Take time to relax. A holiday getaway is all about making memories…quiet moments by the fire, lots of laughs at the dinner table, and sharing special experiences that only happen at Deep Creek Lake. There is something magical about time spent in our mountain paradise, so "unplug" from reality for a bit and reconnect with your favorite people.
Find your Thanksgiving vacation home now and look forward to making many happy memories.
We wish you all the best this holiday season!


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Transactions listed are from July 1, 1992 to
June 30, 1993.
- July 2, 1992
Signed Gundars Vetra as a free agent.
- August 5, 1992
Signed Bob McCann as a free agent.
- September 8, 1992
Released Randy Breuer.
Traded Sam Mitchell and Pooh Richardson to the Indiana Pacers for Chuck Person and Micheal Williams.
- September 13, 1992
Traded Tony Campbell to the New York Knicks for a 1996 2nd round draft pick (Amal McCaskill was later selected).
- September 25, 1992
Traded Scott Brooks to the Houston Rockets for a 1995 2nd round draft pick (Jerome Allen was later selected).
- November 15, 1992
Traded Gerald Glass and Mark Randall to the Detroit Pistons for Lance Blanks, Brad Sellers and a 2000 2nd round draft pick. The 2nd round draft pick traded to Minnesota was conditional and was not exercised.
- January 11, 1993
Fired Jimmy Rodgers as Head Coach.
Hired Sidney Lowe as Head Coach.
- June 30, 1993
Drafted Isaiah Rider in the 1st round (5th pick) of the 1993 NBA Draft.
Drafted Sherron Mills in the 2nd round (29th pick) of the 1993 NBA Draft.
Traded Felton Spencer to the Utah Jazz for Mike Brown.


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This property is no longer available.Search for Available Property.
89 acres in Franklin County, Texas
Size: 89 acres
Location: In Franklin County, only 1.5 hours northeast of Dallas. Take I30 East to Mt. Vernon. Turn North on 37, drive through Mt. Vernon and proceed North on 37 approx. 6.5 miles. Property is on left and fronts 37 with plenty of frontage. Includes White Oak Creek.
Terrain: What an awesome place! If you're looking for a quick getaway from the hustle of DFW area than look no further! Huge hardwoods tree's and thick brush along with multiple creeks and large neighbors make this superior to all others! Great access with wonderful trails and food plot locations, proven results in harvesting massive river bottom bucks and wild hogs. Even if your simply looking for a place to just get away from it all.
There's plenty of high ground to build a nice home or cabin under the canopies of massive 100 year old Oaks. Outstanding world class fishing in White Oak Creek. Proven results in catching 1-30 lb catfish!
Improvements: Electricity is down road and would have to be extended, rural water line is directly in front of property, paved road frontage, new gates and great trails.
Wildlife: Deer, turkey, wild hogs, bobcats, coyotes, fishing
Price: $1,995 per acre
Contact: Tom Waltz- Listing Agent (817) 913-3773
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NOTE: The information contained herein is provided as general information only and has been obtained from sources deemed reliable. It is provided without any guaranty, warranty or representation, expressed or implied, made by Lands of America, or any related entity, as to the accuracy or completeness of the information. The information is presented subject to errors, omissions, change of price or conditions, prior sale or withdrawal without notice. Prospective purchasers should make their own investigations, projections and conclusions concerning the information.


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Question: Why does the auditor obtain a representation letter from management
Why does the auditor obtain a representation letter from management?
View Solution:
View Solution:
Answer to relevant QuestionsDescribe the purposes of an independent engagement quality review by a quality review partner. Multiple Choice1. An auditor would be most likely to identify a contingent liability by obtaining a (n) a. Accounts payable confirmation. b. Bank confirmation of the entity's cash balance. c. Letter from the entity's ...Items 1 through 16 represent a series of unrelated statements, questions, excerpts, and comments taken from various parts of an auditor's working paper file. Below is a list of the likely sources of the statements, ...Give examples of a client- imposed and a condition- imposed scope limitation. Why is a client- imposed limitation generally considered more serious? For each of the following independent situations, indicate the reason for and the type of financial statement audit report that you would issue. Assume that all companies mentioned are private companies and that each item is ...
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We report on a novel method to create waveguide coupler devices in fused silica by combining the technique of beam shaping with femtosecond laser writing. The method is based on a programmable phase modulator and a dynamic variation of the phase-pattern during the writing process. The major advantage is the possibility to create complex devices in a single sweep by simultaneously writing two or more waveguides with changing separation. The guiding properties and the coupling behavior between the waveguides are investigated.
© 2009 Optical Society of AmericaFull Article | PDF Article
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text: Are You googling for Fuel App Development in Houston TX! Then you located correct blog post. GulfStateSoftware.com is operating for startup & medium size firms .Currently, We have small group to work for startup and mid-size firms to build and maintain their custom business solution. Most of team members are part-time yet professional and freelance programmer. Our team worked for business, production, sales or improvement. Our Team always strives to provide best service in terms of your demand. Let us discuss about your work needs. we can offer you up to 10% discount on your first project. Please contact us at +1-800-959-6184 or


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I don't get it sometimes. There is this girl I liked and a long time ago I asked for her number and she said no. Nevertheless we kept talking and talking. There has been always a special "Spark" between me and her, its kinda hard to explain.
Recently I got annoyed because she would text everybody and their grandmothers, except me. So me, being the person that I am wen she approached me to talk, I told her that perhaps it was better if instead of wasting time talking to me, she could just text somebody and talk to them (I didn't tell her why) and she got upset at me!
I don't get why she talks to me all the time, obviously I'm not "special" or whatever enough to text (like everybody else). As soon as she sees me, she starts talking and joking with me, but it only pisses me off more. Have you ever had anything like this happen?
Most Helpful Guy
Well if you just came out of nowhere with that line, I imagine a lot of people would get irritated about it lol. I mean yeah, you're a bit irritated yourself because to you, it seems like you're just that person she talks to whenever you happen to be around. But don't act like a child about it, if you have a problem- tell her about it. Don't bottle it up then just unleash it on someone out of nowhere. That's the much better way to go about things than to just let it stew inside of you and make you bitter about it. Have some balls to be upfront with people because trust me, there are plenty of cowards in the world who can't even voice objections to things. Stepping up and saying something to someone that is irritating you will not kill you.11|00|0