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Lethal Perinatal Thrombosis in Mice Resulting From the Interaction of Tissue Factor Pathway Inhibitor Deficiency and Factor V Leiden
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Background— Factor V Leiden (FVL) is a common genetic risk factor for thrombosis in humans. The incomplete penetrance of FVL suggests important contributions from other genetic or environmental modifying factors. Variation in the expression of tissue factor pathway inhibitor (TFPI) has also been proposed as a risk factor for venous thrombosis and has been shown to enhance the prothrombotic effect of FVL in vitro.
Methods and Results— To examine the potential in vivo interaction between Tfpi and FvL, we analyzed crosses between mice carrying FvL and a deficiency of TFPI. The FvQ/Q,Tfpi+/− genotype was nearly completely fatal in the early perinatal period. Increased fibrin deposition was observed in multiple organs from the FvQ/Q,Tfpi+/− fetuses, suggesting disseminated thrombosis.
Conclusions— These observations demonstrate the prothrombotic effect of modest variations in the level of TFPI expression and suggest that TFPI could be an important genetic modifier for the thrombosis associated with FVL in humans.
Received December 8, 2001; revision received March 22, 2002; accepted March 25, 2002.
Complications of venous thrombosis are a common cause of morbidity and mortality. Factor V Leiden (FVL), a missense substitution in the factor V gene resulting in the replacement of arginine at amino acid position 506 by glutamine, is a common polymorphism in European populations and is found in 20% to 50% of patients presenting with venous thrombosis.1–3⇓⇓ However, the relative risk of thrombosis is only 2.7 in FVL carriers.4 This incomplete penetrance is similar to that of other known genetic risk factors for thrombosis. Several reports have documented enhanced thrombosis risk associated with FVL and the cosegregation of other known prothrombotic genetic risk factors, such as mutations in protein C,5 protein S,6 antithrombin III,7 and prothrombin.8
Tissue factor, the primary initiator of blood coagulation, is regulated by tissue factor pathway inhibitor (TFPI).9 TFPI is a Kunitz-type proteinase inhibitor that regulates extrinsic pathway initiation of coagulation by producing factor Xa-mediated feedback inhibition of the factor VIIa/tissue factor (TF) catalytic complex. Animal studies have demonstrated an important in vivo regulatory role of TFPI in vascular thrombosis.10,11⇓ Variations in TFPI expression may be particularly important in the setting of other prothrombotic risk factors. In a synthetic in vitro assay of thrombin generation, reduction of TFPI concentration by 50% resulted in a slight increase in thrombin generation. However, when combined with factor V Leiden, the same reduction in TFPI concentration led to a marked increase in thrombin generation similar to that observed in the complete absence of the protein C pathway.12
To test the hypothesis that modest reductions in TFPI levels will also enhance factor V Leiden associated thrombosis in vivo, we analyzed mice carrying combined mutations in the Fv and Tfpi genes.
Mice carrying the murine homologue of the factor V Leiden mutation (FvQ)13 or the TFPI Kunitz domain deletion14 were generated as previously described. These mice were backcrossed to C57BL/6J mice (Jackson Labs, Bar Harbor, Maine) for 4 to 10 generations for FvL and 2 to 7 generations for Tfpi before crosses were performed. Genotyping for Tfpi14 and FvQ status13 was done by polymerase chain reaction analysis of tail DNA using the oligonucleotide primers previously described. All mice were maintained on normal chow in specific pathogen-free (SPF) facilities. All animal care and experimental procedures complied with the principles of Laboratory and Animal Care established by the National Society for Medical Research and were approved by the University of Michigan Committee on Use and Care of Animals.
Fetuses were retrieved and fixed as previously described.13 Fibrin(ogen) immunohistochemistry of selected tissues was performed as previously described.15 Tissue fibrin(ogen) staining was graded by a blinded observer using a qualitative scale roughly corresponding to the amount of stainable fibrin(ogen) as a percentage of each section (0, 0%; 1, 1% to 10%; 2, 11% to 50%; and 3, 51% to 100%). Adult mice were perfusion fixed as previously described,11 and multiple organs were sectioned and stained with H&E.
Statistical Analysis
The significance of survival differences between groups was determined using the χ2 test, and differences in fibrin(ogen) tissue staining were determined using the Student's t test.
Effect of Heterozygous Tfpi Deficiency on the FvL Phenotype
To determine the effect of combined mutations in the Fv and Tfpi genes, mice homozygous for FVL (FvQ/Q) (N4) were first crossed with heterozygous TFPI-deficient mice (Tfpi+/−) (N2). Double-heterozygous mice (FvQ/+,Tfpi+/−) were then crossed to homozygous FvL mice (FvQ/Q,Tfpi+/+) to generate 4 possible genotypes with an expected frequency of 25% each. As shown in the Table, only 2 of 94 offspring with the FvQ/Q, Tfpi+/− genotype were observed at the weaning age of 3 weeks, and 1 of these died shortly after weaning. This marked underrepresentation of the FvQ/Q, Tfpi+/− genotype was significantly different than the expected Mendelian frequency. To determine whether the loss of FvQ/Q, Tfpi+/− mice was occurring in the perinatal period or earlier in embryonic development, progeny from timed matings were analyzed shortly before birth at 18.5 days after conception. At this late stage in embryonic development, the expected equal mendelian distribution of all potential genotypes was observed. These results indicate that the FvQ/Q, Tfp+/− mice die sometime between birth and weaning, most likely in the immediate postnatal period.
Because we have reported previously that mouse strain background influences the phenotype of the FvQ/Q mutation, survival analysis of FvQ/Q, Tfpi+/− mice was repeated after FvL and Tfpi+/− mice had been backcrossed to the pure C57BL/6J strain for a total of 10 and 7 generations, respectively (Table). Of 154 offspring analyzed from this cross, no surviving FvQ/Q, Tfpi+/− mice were observed. These results confirm the lethality of the FvQ/Q, Tfpi+/− genotype.
As shown in Figure 1, extensive fibrin(ogen) staining was detected in the liver, lung, and kidney from FvQ/Q, Tfpi+/− neonates, whereas only scant staining was noted in FvQ/Q, Tfpi+/+ neonates. The mean (±SD) fibrin(ogen) staining score for multiple liver, lung, and kidney sections from 5 FvQ/Q, Tfpi+/− neonates was 2.3±0.5 compared with 1.0±0 for 4 FvQ/Q, Tfpi+/+ neonates (P<0.00001). The sole surviving FvQ/Q, Tfpi+/− adult mouse was found to be circling and gasping in the cage at ≈1 year of age. The mouse was killed, and autopsy revealed an occluded inferior vena cava (gross observation) with dilated accessory venous circulation evident. Histology showed intravascular thrombosis in liver and lung with bilateral renal infarctions (Figure 2).
Factor V Leiden (FVL) has a prevalence of 2% to 7% in most European populations1,3,16⇓⇓ and is the major known genetic risk factor for thrombosis in humans. In a small subset of patients, thrombosis is associated with coinheritance of other prothrombotic gene mutations.5–8⇓⇓⇓ However, the potential contribution of additional genetic risk factors in most patients remains unknown. Mice homozygous for the murine FvL mutation exhibit spontaneous thrombosis that is variable depending on the background genetic strain, indicating the presence of strain-dependent genetic modifiers of thrombosis.13 Thus this model is useful for evaluating the impact of potential modifier genes on thrombophilia and recently has been used to unmask the subtle prothrombotic phenotype of mice deficient in protein Z.17 Protein Z–deficient mice appeared indistinguishable from their littermates. However, when crossed with FvL mice, homozygous protein Z– deficient mice who are also heterozygous or homozygous for FvL exhibited a partial or complete perinatal lethal phenotype, respectively. Taken together with the previous protein Z observations, these data suggest that novel interactions of FVL with multiple other genetic loci may be an important determinant of thrombosis penetrance or severity.
Polymorphisms involving human TFPI recently have been proposed to contribute to venous thrombosis risk, although this is controversial.18 Mice homozygous for an inactive Tfpi allele generated by gene targeting exhibit an embryonic lethal phenotype that seems to be attributable to disseminated thrombosis. Even though heterozygous mice exhibit only 50% of functional TFPI activity in the serum compared with wild-type littermates, they develop normally without evidence of spontaneous thrombosis.14 Our observation of a synthetic lethal interaction between FVL and heterozygous TFPI deficiency is consistent with a previous in vitro study demonstrating that combination of the FVL mutation and reduced TFPI leads to a marked increase in thrombin generation.12 The report of significantly decreased free and total plasma TFPI levels in symptomatic patients with FVL compared with asymptomatic FVL patients19 additionally supports the potential relevance of our observations in this murine model system for FVL in humans.
We previously have demonstrated that heterozygous Tfpi deficiency in mice affected time to occlusive thrombosis after endothelial injury at the site of an atherosclerotic plaque.11 However, no difference in the time to occlusion was noted in the absence of preexisting vascular disease. In the present study, we have demonstrated that heterozygous Tfpi deficiency is uniformly lethal in mice that are also homozygous for FvL, whereas neither defect alone results in significant mortality. These findings highlight the sensitivity of this genetic cross for detecting prothrombotic gene interactions and suggest that the FVL mouse may constitute a powerful tool for sensitized screening of potential genetic risk factors for thrombosis.
Although the precise cause of death in these animals has not been definitively identified, a disseminated thrombotic process occurring shortly after birth is likely, judging by the widespread increased tissue fibrin deposition observed in neonates. These results demonstrate a critical in vivo interaction between TFPI and FVL in the regulation of thrombin generation. Taken together, these observations suggest that modest variation in TFPI expression could be an important genetic modifier for the thrombosis associated with factor V Leiden in humans.
This work was supported by National Institutes of Health grants HL-35989 and PO1 HL5734 (to Dr Eitzman), HL 34462 (to Dr Broze), and PO1 HL5734 (to Dr Ginsburg). Dr Ginsburg is a Howard Hughes Medical Institute investigator.
- ↵Svensson PJ, Dahlbäck B. Resistance to activated protein C as a basis for venous thrombosis. N Engl J Med. 1994; 330: 517–522.
- ↵Griffin JH, Evatt B, Wideman C, et al. Anticoagulant protein C pathway defective in majority of thrombophilic patients. Blood. 1993; 82: 1989–1993.
- ↵Koster T, Rosendaal FR, de Ronde H, et al. Venous thrombosis due to poor anticoagulant response to activated protein C: Leiden Thrombophilia Study. Lancet. 1993; 342: 1503–1506.
- ↵Ridker PM, Hennekens CH, Lindpaintner K, et al. Mutation in the gene coding for coagulation factor V and the risk of myocardial infarction, stroke, and venous thrombosis in apparently healthy men. N Engl J Med. 1995; 332: 912–917.
- ↵Koeleman BPC, Reitsma PH, Allaart CF, et al. Activated protein C resistance as an additional risk factor for thrombosis in protein C-deficient families. Blood. 1994; 84: 1031–1035.
- ↵Zöller B, Berntsdotter A, GarcíadeFrutos P, et al. Resistance to activated protein C as an additional genetic risk factor in hereditary deficiency of protein S. Blood. 1995; 85: 3518–3523.
- ↵Van Boven HH, Reitsma PH, Rosendaal FR, et al. Factor V Leiden (FV R506Q) in families with inherited antithrombin deficiency. Thromb Haemost. 1996; 75: 417–421.
- ↵De Stefano V, Martinelli I, Mannucci PM, et al. The risk of recurrent deep venous thrombosis among heterozygous carriers of both factor V Leiden and the G20210A prothrombin mutation. N Engl J Med. 1999; 341: 801–806.
- ↵Girard TJ, Warren LA, Novotny WF, et al. Functional significance of the Kunitz-type inhibitory domains of lipoprotein-associated coagulation inhibitor. Nature. 1989; 338: 518–520.
- ↵Ragni M, Golino P, Cirillo P, et al. Endogenous tissue factor pathway inhibitor modulates thrombus formation in an in vivo model of rabbit carotid artery stenosis and endothelial injury. Circulation. 2000; 102: 113–117.
- ↵Westrick RJ, Bodary PF, Xu Z, et al. Deficiency of tissue factor pathway inhibitor promotes atherosclerosis and thrombosis in mice. Circulation. 2001; 103: 3044–3046.
- ↵van't Veer C, Kalafatis M, Bertina RM, et al. Increased tissue factor-initiated prothrombin activation as a result of the Arg506 –> Gln mutation in factor VLEIDEN. J Biol Chem. 1997; 272: 20721–20729.
- ↵Cui J, Eitzman DT, Westrick RJ, et al. Spontaneous thrombosis in mice carrying the factor V Leiden mutation. Blood. 2000; 96: 4222–4226.
- ↵Huang Z-F, Higuchi D, Lasky N, et al. Tissue factor pathway inhibitor gene disruption produces intrauterine lethality in mice. Blood. 1997; 90: 944–951.
- ↵Eitzman DT, Westrick RJ, Xu Z, et al. Plasminogen activator inhibitor-1 deficiency protects against atherosclerosis progression in the mouse carotid artery. Blood. 2000; 96: 4212–4215.
- ↵Rees DC, Cox M, Clegg JB. World distribution of factor V Leiden. Lancet. 1995; 346: 1133–1134.
- ↵Yin Z-F, Huang Z-F, Cui J, et al. Prothrombotic phenotype of protein Z deficiency. Proc Natl Acad Sci U S A. 2000; 97: 6734–6738.
- ↵Franco RF, Reitsma PH. Genetic risk factors of venous thrombosis. Hum Genet. 2001; 109: 369–384.
- ↵Van Dreden P, Grosley M, Cost H. Total and free levels of tissue factor pathway inhibitor: a risk factor in patients with factor V Leiden? Blood Coag Fibrinolysis. 1999; 10: 115–116.
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- Lethal Perinatal Thrombosis in Mice Resulting From the Interaction of Tissue Factor Pathway Inhibitor Deficiency and Factor V LeidenDaniel T. Eitzman, Randal J. Westrick, Xiaoming Bi, Sara L. Manning, John E. Wilkinson, George J. Broze and David GinsburgCirculation. 2002;105:2139-2142, originally published April 15, 2002https://doi.org/10.1161/01.CIR.0000017361.39256.82
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- Lethal Perinatal Thrombosis in Mice Resulting From the Interaction of Tissue Factor Pathway Inhibitor Deficiency and Factor V LeidenDaniel T. Eitzman, Randal J. Westrick, Xiaoming Bi, Sara L. Manning, John E. Wilkinson, George J. Broze and David GinsburgCirculation. 2002;105:2139-2142, originally published April 15, 2002https://doi.org/10.1161/01.CIR.0000017361.39256.82Permalink:


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Who has some? My little siblings do, and I sometimes watch Kiki's delivery service lol
But seriously, I feel like the only one under 20 who actually knows what that is (beside my siblings and their friends) and the only one under 40 who has some in their house
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You mean a VHS and a VCR.
I have the Indiana Jones trilogy on VHS and some other movies.
I remember watching movies in class and the teacher would bring out the VCR it was always so exciting.00|00|0
Yeah, I realised what they were called after I posted it lol. Sometimes I forget for like, 5 minutes then remember again.
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Thanks for MHO
Np! :)
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No Not me!00|00|0

subset: commoncrawl


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The company expects fourth-quarter sales to increase 15%-20% sequentially to $3.8 billion-$4.0 billion. It is seeing strength in almost all of its segments and said demand has not been materially affected by the economic issues hanging over Europe (where more than 30% of Jabil's sales are located). This positive outlook lends support to the notion that the strong demand seen recently in tech is not yet being affected by macroeconomic issues or experiencing any slowdown in demand. We expect demand for Jabil's services to remain strong through the summer and think the company will see results improve again sequentially next quarter.
Jabil is an electronic product solutions company providing comprehensive electronics design, manufacturing and product management services to global electronics and technology companies. Offering complete product supply chain management from facilities in 22 countries, Jabil provides comprehensive, individualized-focused solutions to customers in a broad range of industries. Jabil common stock is traded on the New York Stock Exchange under the symbol, "JBL".


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If any musician still needs validation of the importance of always giving your best when performing live, Josh Fewings of Mayhemingways has a story to share.
In August 2014, Fewings and bandmate Benj Rowland performed at the Peterborough Folk Festival. Unknown to them, Juno Award-winning recording artist Joel Plaskett was in the Nicholls Oval Park crowd, later catching up with the Peterborough musical duo at a festival after-party.
"He dug us," recounts Fewings, noting Plaskett invited him and Rowland to drop by his Dartmouth, Nova Scotia recording studio the next time they were down east. They eventually did just that last year, with Plaskett then catching their act in a neighbouring Halifax pub.
The @MAYHEMINGWAYS @CarletonHalifax . Go see this band. pic.twitter.com/DnL41iqBa3
— Joel Plaskett (@joelplaskett) June 10, 2016
With studio work completed on Solidarity, an album written and recorded with his father Bill, Plaskett looked to touring the new music in 2017. Some 1,200 kilometres distant, Fewings' phone buzzed.
"Joel asked if we were free in March and April," Fewings says. "The only thing we had planned was to do a little tour of Europe, but we only had three or four gigs booked so we cleared our calendar."
"Him asking us (to tour) so out of the blue is mind blowing. He has a really good band (The Emergency) but this tour is about the album with his dad and he wanted a different approach on it. Anytime someone like Joel Plaskett asks you tour, that's a good day."
With Solidarity due to be released on February 17th, the 20-stop cross-Canada tour begins on March 15th in Truro, Nova Scotia. So far, the only show in the Kawarthas is on Wednesday, May 3rd at the Academy Theatre in Lindsay (tickets are $34.50 and can be ordered at www.academytheatre.ca or phone 705-324-9111. For all the tour dates, visit joelplaskett.com/tour/
As well as backing up the Plasketts, Mayhemingways will open each show, with lead singer Rowland switching between accordion, banjo, guitar, and tenor guitar (while holding down the bass using foot pedals) and Fewings on drums, percussion, and back-up vocals. This allows the duo to produce a big sound for their mix of originals, traditional tunes, and covers, all with distinct Cajun, blugrass, country, and Celtic influences. They've been described as folk-rock, alt-country, and "fuzz-folk".
"The Mayhemingways are great," Plaskett tells me in a phone interview. "They make a real racket for two guys. And I mean racket in a good way. I thought it would be a neat fit."
VIDEO: "Altantic City" by Bruce Springsteen, performed by Mayhemingways
The new record and tour with his dad Bill is a new direction for Plaskett.
"It's strange for me to not bring my band on the road with me — it's a huge part of what I've done," Plaskett explains. "But I wanted this record to be about my father and me. If I have the band there, the expectations are for the show to end up in a big rockfest. With my dad, that's not the end game. I want to be able to control the dynamics, with a more acoustic presentation. I pick the points where the electricity is there."
And the 40-year-old Plaskett has generated a lot of electricity over the last 24 years as a singer, songwriter, and multi-instrumentalist. His initial foray into the music business saw him serve as lead singer and guitarist for Halifax-based Thrush Hermit and, in the late 1990s, drummer for Neusiland. After both bands broke up, that's when things really fell into place for the Lunenburg native.
Fronting The Emergency, Plaskett earned a Juno Award nomination in 2002 as Best New Artist — a nod earned via critical acclaim for the trio's debut album Down At The Khyber. Follow-up album Truthfully, Truthfully brought commercial success the trio's way.
All the while, Plaskett kept hard at it as a solo artist as well, recording four albums in total, the latest being 2015's The Park Avenue Sobriety Test. And the plaudits kept coming his way: five more Juno Award nominations and a win in 2010 for Adult Alternative Album of the Year for Three, as well as numerous nominations and wins at the East Coast Music Awards.
VIDEO: Bill & Joel Plaskett – Solidarity Album Trailer
In 2016, a project that been percolating for some time finally got his full attention.
"My dad has been an inspiration but also someone I learned from when I was younger," Plaskeet says. "I'd been wanting for awhile to document what he does and sort of collaborate with him."
"Since I've become a parent, I feel the clock ticking a little bit. Becoming a father myself, I realize the connection I have with my dad is powerful. He's still very able-bodied, but he's in his seventies now and neither of us is getting any younger. So it was 'Let's make a record together.' It's something I'm really lucky to be able to do. I'm hoping this may be the first of several records we do."
Describing his father as "a good singer and guitar player in his own right," Plaskett says the album features songs written by both himself and his dad.
"It's definitely a folkier side of what I do. My dad and I share a love of folk music; English stuff from the 1960s and 1970s. There are influences that we share. It's folky in its instrumentation but it's also got a little political undercurrent, social commentary, stuff like that. We recorded the album during the run-up to the American election. Not that we were writing about that, but that was sort of the backdrop."
"The song Solidarity isn't a political song per se but, to me, the title and what it represents sort of ties in to my and my dad's story. The verses are little vignettes from our lives. The older I get, the more my own politics creep into my writing. At the same time, it's not all about that. There are love songs on the record too."
While touring is nothing new for Plaskett, touring with his dad is — and that has both father and son excited for what lies ahead.
"My dad and I playing music together is something real," he says. "I've had people tweeting me that 'I bought tickets for me and my mom' or 'for me and my dad'. My 20-year-old self probably would have thought that's not very punk rock but, where I am in my life now, it makes me happy to hear that."
Not lost on Plaskett is how fortunate he has been to prosper in a business where fame is often fleeting at best.
"I don't have a back-up plan. I think that's why I'm still playing, to be honest. I don't have an education to fall back on. My education is basically my experience playing music and writing songs, and learning how to perform them live and putting on a strong show. The fact that I'm able to carve out a living is really a blessing. To be able to include my dad in that is even better."
VIDEO: "Hunter Street Blues" – Mayhemingways
On January 16th, the Plasketts will welcome Fewings and Rowland back to their Nova Scotia studio where they'll rehearse for the tour. For Fewings, there's a sense that "a cosmic alignment is happening" in terms of Mayhemingways' good fortune.
"I like to think it's been pretty well earned from playing as much as we can since we got together," says Fewings, adding, "Even if this hadn't come about, we would still feel very good about what we've done."
Ahead for the duo, prior to the Plaskett tour, is a February trip to Alberta to record tracks for a new album — a follow-up to their 2016 critically acclaimed debut album Hunter Street Blues.
Meanwhile, for Plaskett, post-tour will see much more of the same: writing and recording with the addition of exploring "something more conceptual" with his friend and songwriter Shotgun Jimmy. But the tour with his dad, he says, is currently at the centre of his universe.
"I love playing gigs," he says. "It makes me feel more connected to people. It makes me feel like I'm part of something. There's a shared energy. It feeds my ego too — don't get me wrong, but it has a lot to do with not feeling so alone in the world."
Reminded that Lindsay's Academy Theatre, where he's played before and will again on May 3rd, lays claim to a resident ghost, Plaskett isn't concerned.
"I heard that. I sort of believe in that stuff, so I'm ready. Bring it on."
That's a sentiment no doubt shared by many who are anxious to experience his new tour with his dad Bill and Mayhemingways.


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Over the past 24 years, I have taught workshops around the world. I have demonstrated drawing with a sewing machine for Jenny Murray on R4's 'Women's Hour', I've taught Kirstie Allsopp a 'Drawing with Stitch' master class on Kirsty's Homemade Home and have a fabulous workshop review by Emma Kennedy's 'Eccentric Britain' The Guardian. (See Press)
I love teaching and I feel I have a responsibility to ignite the creative potential in the people that I meet.
I am working with PUKKA herbs to create an advertising campaign to promote womens health and creativity.
Watch this space!
I'll make up for it next year I promise!
This January 2017 I flew to Australia to teach a series of workshops in Perth, Margaret River and Melbourne. It was the most fantastic trip and I met many inspiring ladies who put the va va voom back into my practice as an ambassador of stitch.
Please email me to be on my workshop mailing List.
Workshops fill up very fast - only 2 or 3/ year.
1. Please fill in the Booking Form to register your place and check availability - (PLEASE ADD EMAIL ADDRESS & phone.)
2. Please pay a £200 deposit through paypal or BACS to secure your place. If you would like to send a cheque please email me through my website.
3. I will contact you within two weeks of receiving your booking to confirm receipt of your deposit.
4. Please sort out your sewing machine, get it serviced and make sure you have the right foot for free motion emb.
Follow me on TWITTER @loulougardiner for the latest news updates.
You can also email me to be added to my workshop waiting list.
SUPERSTITCHERS - What's it all about?
These workshops are suitable for all abilities as I teach new and fun approaches to drawing with stitch.
With the aid of relaxed and spacious surroundings, sherry, music and enthusiasm we get cracking on creativity.
To begin, we concentrate on mark making on paper and then move to drawing with the sewing machine, creating painterly surfaces and embroidery and embellishing with stitchery witchery and sparkle.
I demonstrate at regular intervals the techniques that I use in my studio, enabling students to sit back, rest and usually have a laugh. At the end of the course you will have a fun and unique caricature and the skills and confidence to go home and start experimenting on your own machine. Suitable for beginners and anyone who wants to learn spontaneous ways of working or to kick start their creativity or be re-inspired.
- You WILL be encouraged to take wonderfully exciting risks with thread and colour.
- You WILL leave with your very own 'Lou Gardiner inspired piece of artwork which will spring board you into your own creative development. ......................................................................................................
Students are required to bring their own sewing machine.
I use a BERNINA 1008 which are ideal for drawing and creative work. Your sewing machine needs to do 'FREE MOTION EMBROIDERY/ DARNING with an appropriate foot and you also need to be able to take the 'feed dog teeth down'.
See this link to see the presser foot that I use -http://www.bernina.com/en-US/Products-us/BERNINA-products-us/BERNINA-Accessories-us/Presser-feet-us/Darning-foot-en
If you would like to book a place on a course and can pay by PAYPAL or BANK TRANSFER (BACS) complete the online form below and make sure your machine is ready and you have the needs list. NO WORKSHOPS PLANNED FOR 2017.
My Superstitcher Students have said ...
"Amazing experience! I'm so excited I cant sleep! I feel like a huge new area of creativity has opened up for me. I feel like I have unlocked something and the possibilities are endless. " Tim, Brighton.
'Queen of stitch and Queen of Masking tape! Brilliant course by the best tutor I have ever had at anything!" Wendy C.
"Going home inspired and happy.' Beth M.
'Absolutely fantastic week again! I have SO much more confidence which is just what I needed. " Jenny.
'My second workshop with you and just as inspirational as my first. Thank you for pushing my boundaries and all the generous encouragement.' Patricia M.
"Absolutely wonderful three days - the time has flown and I have enjoyed every second! Thank you L for being so inspirational and offering such a great work atmosphere." Peta K.
"This course is life changing! I am so inspired to realise my creative potential. On top of that it is simply great fun. The best course I have been on." Maggie. London
"Your warmth and sparkle shines through your teaching and your work. Thank you." Angela O.
"Fabulous three days. I loved the encouragement, the lack of rules, the break up of the days that reduced back and neck strain and kept the mind coping with all the stimulation. Brilliant!" Maureen, Margaret River, Australia.
"I have had a fantastic bonkers few days. I know I will go on to do much more!" Janet.
"I've been twice in four months... That says it all!" Glynnis.
Quarry Bank Mill Students - Canvas provided
A small selection of pens Eg. fine liners, felt tips or soft pencils (4B, 6B)
Black Marker Pen
BIRO - black or blue
Roll of Masking Tape
3 x A2 Sheets of paper
1 Sheet of Tracing paper or baking parchment
For Painting (all workshops)
Good quality acrylic paint brush - small rounded OR medium rounded.
Jam jar for water
Palette / Old Plate
Small selection of acrylic OR water soluble pencils/pastels.
(Oil, Gouache and chalk pastels ARE NOT SUITABLE)
METALLIC PAINTS or Pearlescent White acryllic which you can mix with other
colours lovely to use. OPTIONAL BUT LOVELY!
Sewing machine that you know works well with free machine stitching - PLEASE TRY AND TEST!!!
Free motion foot for embroidery already fitted to your machine. (DOES not necessarily come with!)
Don't forget the foot pedal and lead!
Minimum 1000m - Black Thread - Good Quality (Madeira, Gutterman, Marathon, Coats....)
Pack of Spare needles - size 80 / 90
Scissors for thread and fabric
Spare bobbins - at least 4
Selection of coloured threads including a few metallic threads
For APPLIQUE Workshops
Small selection of scraps of fabric for appliqué Colourful,type Fabrics
For Jazzy Garments workshop ONLY
Please bring a selection of fabric scraps and textile paints that can be set with an iron. You can also bring sequins and beads, feathers and sparkles but remember that you will need to be able to clean your garment.
Sherry will be provided!
Make sure that you can definitely do the workshop dates before booking.
£200 Deposits are non-refundable.
The final balance of the workshop cost is required a month before the workshop commences.
Thank you.


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ESPN the other day did a segment where reporter Katie Linendoll had quarterback Sam Bradford and wide receiver Tavon Austin of the St. Louis Rams play catch while wearing Google Glass.
"What about the latest tech buzz, Google Glass: Could it work in the NFL?" Linendoll asks introducing the segment. And the answer is why yes, yes it could, at least if you're talking about one NFL player tossing a football and another one catching it on a practice field in the summertime. Watch:
But what about Google Glass really working in the NFL, as in being used in an actual game? That was the essence of the question.
Well, there would be obstacles and they were not addressed, one being that the NFL today only allows in-game electronic communication between the quarterback and a coach (plus one defensive player), despite the fact that crowd noise often prevents even nearby offensive linemen from hearing the snap count. I'm having a hard time envisioning the rules committee making a leap from today's near technological prohibition all the way up to Google Glass.
But never mind the rules; maybe Google writes a big enough check and that issue goes away.
(Geek-themed Meme of the Week Archive)
The obstacle that I cannot see Google Glass overcoming on an NFL field is the likes of Jadeveon Clowney, he of perhaps the most famous football tackle since Chuck Bednarik of the Philadelphia Eagles nearly decapitated Frank Gifford of the New York Giants back in 1960. ESPN has been playing last year's Clowney tackle every 10 minutes or so recently both because it's nominated for an ESPY Award and it's astonishing to watch no many how many times you've seen it before. Take a look:
Now imagine if the running back had been wearing Google Glass. Enough said.
Welcome regulars and passersby. Here are a few more recent buzzblog items. And, if you'd like to receive Buzzblog via e-mail newsletter, here's where to sign up. You can follow me on Twitter here and on Google+ here.
- Google Glass in the NFL? ... Two words: Jadeveon Clowney.
- John Malkovich makes Redditor a voicemail greeting.
- Minecraft in Latin? … Perhaps now the pope will play.
- Geek-themed Meme of the Week: No. 4.
- State finds grocery store pricing 100% accurate?
- 1776 "iPhone Liberation Kits" go faster than Paul Revere's horse.
- Creator of hashtag explains why he didn't patent it.
- AG wants to autocomplete war on drugs.
- Hey, Cambridge, Netscape 4.0 was released in 1997.
- Hidden yodelers on Yahoo homepage fall silent.
- Torvalds: Stop me before I curse again.
- Nothing says narcissist like wearing Google Glass on a date.
- Microsoft's opening act since Windows 95: Weezer.
- Will entering your ATM PIN in reverse summon the police?
- 2013's 25 Geekiest 25th Anniversaries


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Details & Description
Wear your team pride for all to see in the fresh '47 Boston Red Sox MLB Clean Up Adjustable Hat. Soft cotton blend material is durable and breathable, while embroidered team details front and center shout your allegiance to the world. A strapback ties it all together, ensuring you get a perfect fit.
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Furniture Hire Bellshill
Looking for furniture hire in Bellshill? Get a quote for furniture for hire in Bellshill using Add to Event.
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text:
That's right, after a short matter of time, it has been discovered how you can join the
- Open up Internet Explorer. MSN likes Internet Explorer, and hates Firefox. (Damn Microsoft!)
- For this to work, you must be signed out of MSN. Go to the MSN Homepage, and double check you are signed out.
- Copy this URL to Internet Explorer: Right Click On Here -> Copy
- You should be redirected to another URL (Another URL to login). Sign in.
- You should see the regular
Hotmailonce signed in.
- Once you see the regular Hotmail, do Step #3 again. Copy the same URL above.
- Click ?Participate? on the bottom (Scroll down!) and walla!
News Source: Computer Help Forum


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Surprise 'Games of Thrones' Clips Are Really Deep, Man
The phrase "drunken dwarf" is uttered.
April 12 is coming. But until that day synchs with our extended families' HBO Go accounts (or HBO Now, as the case may be), here are two clips (one new and another re-released) to help tide you over.
The first, featuring Tyrion Lannister and Lord Varys, takes place on a scenic balcony overlooking the sea. As Tyrion pours himself a cup of wine, he asks Varys a question: "Why did you save my life?" Varys being Varys, he gives a response only he could come up with:
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The other is darker, taking place in a wintry jail cell. There, clad in heavy fur and holding some kind of rain stick, Jon Snow confronts a haggard Mance Rayder about the real reason he brought clans together. Was it his ... pride?!
More from Esquire:


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World's Finest Pool Floats
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World's Finest Pool Float in Aruba Blue is rated out of 5 by 548.
Rated 5 out of 5 by kidsfun from kids love it!
Date published: 2011-06-22
Rated 5 out of 5 by Butterfly from Great Quality! This is just like the mat I rent when on vacation in Aruba. Love it!
Date published: 2011-06-22
Rated 5 out of 5 by Marcy from Best float ever!!! So glad I splurged on these floats! Totally worth every penny! Very thick, not like most floats. Planning to purchase a couple more!
Date published: 2011-06-21
Rated 5 out of 5 by Augie from Great pool float We ordered one of these and liked it so much we ordered another.
Date published: 2011-06-21
Rated 5 out of 5 by LAMB from BEST RAFT EVER! We are SO happy with our purchase! My teenage son and I fight over it every time we swim. I guess I'll have to buy another. Some may think it's too expensive but in some cases you get what you pay for and this is one of them! Well worth the money!!!
Date published: 2011-06-20
Rated 5 out of 5 by summerlover from Well worth the money! I've bought several of these type floats previously, from other merchants, however they were never as thick as the Frontgate floats! I am very pleased with this product!
Date published: 2011-06-19
Rated 5 out of 5 by Sunshine from Excellent purchase I purchased this pool float for my son and his family, attracted by the sale price and the Frontgate reputation. Although it was the least expensive, one would never guess it. The quality and appearance was impressive and it was delivered quicker than expected. I was a little concerned about the smell when first out of the box but was reassured by the explanation that came with it, and once in the pool it dissipated quickly. Catch this before it goes off sale!
Date published: 2011-06-19
Rated 5 out of 5 by 17mikes from Float to Paradise Used it for the 1st time this afternoon. So comfortable I almost feel asleep floating in my pool. Sure I'll have a hard time getting back on as others try it out !
Date published: 2011-06-18
Rated 5 out of 5 by LauraK from Love the pool float
Date published: 2011-06-18
Rated 5 out of 5 by CarolynH from GO FOR IT! A GREAT PRODUCT. This mat is totally amazing. It is the BEST I have ever had and we have had a pool for 20 years. It is THICK, you don't get your hair wet when laying down, you don't sink into the water, the kids can jump and stand on it and its pretty to look at!! We ordered two and will order another next year!!! GO FOR IT...you won't be sorry at all.
Date published: 2011-06-17
Rated 5 out of 5 by nicki from Best floats ever! The World's Finest Pool Float is indeed just that. No more "blowing up floats" for the pool! These floats are comfortable and a great value for the price.
Date published: 2011-06-17
Rated 5 out of 5 by cembry from Best pool raft out there This pool raft is my favorite. It is thick enough, wide enough, long enough and I love it. I own two.
Date published: 2011-06-17
Rated 5 out of 5 by Gail from World's Finest Pool Floats The floats were excellent! Thick, very cushiony, great colors and extremely comfortable.
Date published: 2011-06-16
Rated 5 out of 5 by TheL3 from Buy this float! Just received the mango-colored float, and love it so much I ordered another one in kiwi green! Comfortable, soft (but not flimsy), buoyant, with a nice head rest that's not too tall. I'm very very satisfied with this product.
Date published: 2011-06-16
Rated 5 out of 5 by njcmfw from pool floats i first bought these pool floats from frontgate approximately 10 years ago. they still were fine, the best floats ever for durability and comfort but started to age after 10 years. Also the colors no longer went with any of our new pool furniture. I just bought 4 new ones (kiwi) as a treat to myself. I was so pleasantly surprised that, 10 years later, the quality of these pool floats (in terms of thickness) seemed even better than the original ones i purchased 10 years ago. how often does that happen? even better, i got them on sale and i swear i paid less for this year's model than the original ones (certainly no more).
Date published: 2011-06-10
Rated 5 out of 5 by jandr from Finest Quality After spending quite some time shopping online, we decided that the World's Finest Pool Floats from Frontgate were the ones for us. Upon arrival, we were thrilled with the quality. My husband is 6'4" and these floats are plenty long enough for him. The extra thickness make them extremely comfortable and we couldn't be happier. It's always a little scary buying without seeing, but these are just as great as described. If you are looking for a comfortable, good sized float, these are the ones for you.
Date published: 2011-06-06
Rated 5 out of 5 by Napamom from Quality This product is sturdy and exactly what is described in the reviews. It came shipped in a roll and quickly straightened out. The ones in the local pool store are much thinner and more money.
Date published: 2011-05-31
Rated 5 out of 5 by sunlover from Relaxing is an understatement This is by far the most comfortable float ever. Sturdy, soft and supportive. The kids know when Mom is in the water, one of the floats belongs to her!
Date published: 2011-05-31
Rated 5 out of 5 by troyfan from EXCELLENT! I've been looking at this float for a year now, and finally decided to get it when it went on sale. Not only is it long and STRONG, but the Frontgate customer service folks are AMAZING! There was a tear on the piece of the rubber. I called, they sent one right out, and had the refund on my visa within a week. Great products AND great customer service!
Date published: 2011-05-28
Rated 5 out of 5 by Lynn from Superb quality These floats are of the best quality that I have experienced. I was amazed at the thickness and the heaviness which will be comfortable for men. I know my family will have many years of use from these floats. I ordered the stand to store these and I highly recommend the stand.
Date published: 2011-05-02
Rated 5 out of 5 by FloridaChick from Awesome Float Best pool float I've ever purchased. It's comfortable and does hold an adult above water. I got the mango and love it. I'm purchasing the aqua one for my husband.
Date published: 2011-04-27
Rated 5 out of 5 by Anonymous from Looks Awesome! I have not yet used our new worlds Finest Pool float, but I plan to in the next few weekends... if the rain ever stops!!! It is beautiful and seems to be quality made.
Date published: 2011-03-31
Rated 5 out of 5 by Anonymous from Stays above water with adult on it! Handles the weight of a large adult . 2 smaller kids can use at the same time. Very comfortable.
Date published: 2011-01-27
Rated 5 out of 5 by Anonymous from well worth it This is the second one of these that I have bought. They are far better than any you will find in a local store! Extra thick & extra soft & do not fade. The only draw back is you have to let it sit for about a week until it "gasses off" the smell! It is pretty stong.
Date published: 2011-01-21
Rated 5 out of 5 by Anonymous from Must Have for any Pool I absolutely love this float. This is my second float. The material is soft and comfortable against the skin. My original float is going on its third season and is in excellent condition. When ordering note the the floats come in different thicknesses. I have have one of each. If you are a large person the 3" will really keep you raised out of the water. I'm 120lbs at 5'9" and I float high in the water and the length is wonderful for tall peeps. I highly recommend this float as a must for any pool. Enjoy!!
Date published: 2011-01-14
Rated 5 out of 5 by Anonymous from POOL FLOAT THE POOL FLOATS ARE GREAT.I HAVE HAD THEM IN THE PASS AND THEY LAST A VERY LONG TIME.I HAVE JUST ORDERED A SECOND ONE
Date published: 2011-01-13
Rated 5 out of 5 by Anonymous from Another great product We have been ordering from Frontgate for years, and when the pool floats went on sale, we sent out emails letting friends and family know! We already own a couple of floats, which have been used as sleeping and exercise mats as well as floats through the years. A great value for a great product.
Date published: 2011-01-13
Rated 5 out of 5 by Anonymous from Name Says It All This is truly the World's Finest Pool Float! Have owned other floats from reputable pool stores and nothing is a thick or durable as these.
Date published: 2011-01-13
Rated 5 out of 5 by Anonymous from Pool Floats Could not be happier, they are esthetically pleasing and comfortable; would recommend to anyone looking for a great price and a lazy day floating in the pool!
Date published: 2010-12-19
Rated 5 out of 5 by Anonymous from exactly what I wanted Had seen commercials for Frontgate in USA newspaper and had seen the aqua float advertised earlier in the year. I decided this was to be a Christmas present to me!! A relative in Maryland had one for her pool and this is exactly what I wanted. Excellent quality, arrived on time and ordered something else from Frontgate a few days later. I just wish I had had the financial ability to order the 60 piece "Noel collection" for my tree! Maybe next year! Thank you Frontgate.
Date published: 2010-12-17
does the odor(as written in the reviews) disappear and how long does it take
You may notice the odor when you open the box or when it's stored in your garage, but when you are actually on the float or in open air, you won't notice it at all.
Date published: 2017-08-17
Cannot get on float
I know this sounds silly but I cannot get on this float. I know it is very well made and nice. It flips over when I try to get on. any advice
Stand backwards on your pool steps, put the bottom of the float against your ankles, and fall back on the float. The float must be in the water!!
Date published: 2017-07-13
Do you happen to know who the black one-piece worn by the model in the product image is made by?
Thank you for your interest in the World's Finest Float in Fuchsia. The one - piece black swim suit worn by the model on the fuchsia colored float was from the Everything But Water website. However, this suit may no longer be available since the picture was taking some time ago.
Date published: 2017-06-08
Do the ripples in the solid colored floats leave imprints on your skin?
I noticed that the solid colored floats have a wavy rippled surface (whereas the white floats with designs are smooth). Do the ripples leave imprints on your skin when lying on them for extended periods of time?
Yes, they do leave imprints on you. My hubby had a lovely zig-zag pattern on his back the other day. Still the product is comfortable and great. Good observation to make, I didn't realize the others were not imprinted.
Date published: 2016-08-27
I would like to buy this to take on a vacation to Florida. Could I fold or roll it up for the trip down in the car?
Yes, for sure. You can roll it and then use packing clear wrap from a moving store to keep it rolled up. The wrap I'm talking about is like a cling wrap but made for wrapping moving items. I would not fold it since I don't know how it would hold up. It comes rolled and I've stored it rolled without a problem. If your first use will be on vacation then don't unroll it when you get it.
Date published: 2016-02-27
Product:14996_FSH-World\'s Finest Pool Floats


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U.S. House Speaker John Boehner (R-Ohio) suggested on Thursday that an upcoming House hearing on "defending marriage" is a "legitimate" use of U.S. government funds as the subcommittee confirmed that witnesses who are set to testify include anti-gay activists.
During a news conference, Boehner made the remarks in response to a question from the Washington Blade on whether he supports the planned hearing, which is set to take place Friday before the House Judiciary subcommittee on the Constitution, and if he thinks the event is an appropriate use of federal resources.
"There are a lot of committees, a lot of hearings," Boehner said. "As I made it clear from the beginning of this year, the committee process is important to this institution, and I think addressing any question — serious question — in American society is legitimate."
Michael Cole-Schwartz, spokesperson for the Human Rights Campaign, said in response to Boehner's remarks that the upcoming hearing will "no doubt showcase the [Republican] majority's obsession with ensuring continued discrimination against same-sex couples."
"They're welcome to think that's a legitimate way to spend their time but the vast majority of Americans will be scratching their heads wondering why House Republicans have held a third hearing in as many weeks to demonize LGBT people," Cole-Schwartz said.
Cole-Schwartz was counting two earlier hearings that House committees held to oversee implementation of "Don't Ask, Don't Tell" repeal as anti-gay hearings and the upcoming testimony on "defending marriage" as the third anti-gay hearing this year.
Also on Thursday, the committee made public the names of the three witnesses who were set to testify, which include two witnesses with a history of anti-gay views. The background of the scheduled anti-gay witnesses lends credence to speculation that the hearing — which is set to begin at 10 am in Room 2141 of the Rayburn House Office Building — will be hostile to same-sex marriage.
Capitol Hill observers say the expect the hearing to be critical of President Obama's announced decision on Feb. 23 to drop defense of the Defense of Marriage Act against litigation in court. Boehner has since directed the House general counsel to take up defense of the anti-gay law.
The most high-profile scheduled witness is Maggie Gallagher, chair of the National Organization for Marriage, who has previously testified before Congress against same-sex marriage and has a history of anti-gay activism. She didn't respond on short notice to the Blade's request to comment for this article.
Another expert who's scheduled to speak is Edward Whelan, president of the Ethics and Public Policy Center and director of center's program on the constitution, the courts, and the culture. A former law clerk to U.S. Associate Justice Antonin Scalia and a high-ranking legal adviser in the Justice Department for former President George W. Bush, Whelan has written several anti-gay tracts as a scholar at the center.
Whelan, who didn't immediately respond to the Blade's request to discuss his testimony, has been critical of the Obama administration for what he said is not vigorously defending "Don't Ask, Don't Tell" against litigation in court and — in essay titled "The Most Egregious Performance Ever by a Federal District Judge" — found fault with U.S. District Court Judge Vaughn Walker's decision last year that determining that Proposition 8 in California was unconstitutional.
"Walker's course of conduct would be sufficient cause for national scandal in any case," Whelan wrote. "That it comes in a case that aims to radically remake the central social institution of American society makes it utterly intolerable."
But another scheduled witnesses at the hearing, Carlos Ball, a gay law professor at Rutgers Law School, told the Blade he plans to argue in his testimony that Obama rightfully determined that DOMA is unconstitutional and that the president shouldn't defend the law in court.
"It is unusual for an administration to decide not to defend the constitutionality of the statute, but it is by no means unprecedented," Ball said. "The first President Bush did it; President George W. Bush did it as well. In my view, any administration has a constitutional obligation to make an independent judgment on the constitutionality of certain statutes, especially when there is no clear law on whether the statutes are constitutional or not."
Additionally, Ball said he plans to testify that DOMA is a "constitutionally indefensible statute" because the states have traditionally enjoyed the prerogative of regulating marriage.
"What the plaintiffs in these DOMA lawsuits are saying is not that they have a federal constitutional right to marry — that's not the issue," Ball said. "These couples are already married under the laws of their states. What that their arguing is that the federal government should not discriminate against their marriages when it comes to federal governments. The administration has concluded that it's unconstitutional to treat differently, and I think they're absolutely correct."
Ball is the author of numerous pro-LGBT scholarly works, including "The Right to be Parents: How LGBT Mothers and Fathers Have Revolutionized Family Law," "From the Closet to the Courtroom: Five LGBT Rights Cases That Have Changed Our Nation" and "The Morality of Gay Rights: An Exploration in Political Philosophy."
Even the Republicans who are members of the subcommittee have a history of anti-gay views. In an interview with Think Progress, Rep. Trent Franks (R-Ariz.), chair of the House Judiciary subcommittee on the Constitution, has said Obama and Holder could impeached over the decision and that he would favor defunding the Justice Department if it doesn't defend DOMA.
Other subcommittee members include Rep. Jim Jordan (R-Ohio), who has initiated to congressional effort to eliminate same-sex marriage in D.C., and Rep. Steve King (R-Iowa), who has repeatedly made anti-gay remarks said gays wouldn't face discrimination if they didn't wear their "sexuality on their sleeve."
Rep. Jerrold Nadler (D-N.Y.), ranking Democrat of the subcommittee, said he hasn't had any conversations with Franks on what he wants to accomplish with the hearing, but plans to attend and expects hostility against the Obama administration.
"This is a hearing really on the administration's decision not to defend DOMA in court," Nadler said. "I think [Franks is] trying to dramatize his position — that the administration is doing a terrible thing by not defending the law."
Nadler said proponents of Obama's decision are prepared to make the point that Obama rightly dropped defense of DOMA because the statute targets married same-sex couples for discrimination.
"I think we're going to make the point that although it's unusual, it's not unprecedented," Nadler said. "In fact, it's required when the administration's legal people decide — as they have in this case on good legal grounds — that the law is indefensible constitutionally."


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Posts tagged "Genomics"
Ebola outbreak brings global attention to tobacco plant-based drugs
It's an eye-catching angle in the story of an experimental treatment for Ebola: The drug comes from tobacco plants that were turned into living pharmaceutical factories. And one of the emerging players is Medicago, which operates a production facility in RTP.
Pfizer, 23andMe team up for genetic study of bowel disease
Pfizer is teaming up with DNA testing company 23andMe to study the possible genetic underpinnings of inflammatory bowel disease, a hard-to-treat ailment that affects an estimated 1.4 million Americans.
N.C. Research Campus internship program plants seeds to grow STEM careers
The future of food research is taking root in some very fertile ground - the minds of students working on the N.C. Research Campus. In an Insider exclusive for WRAL TechWire, read how a new internship program encourages STEM careers
Michael Balloskis, left, and Brooklyn Phillips in the P2EP program.
New Jersey firm buying Gentris for $4.75M; founder to return
Morrisville-based Gentris, which provides storage and testing services to research laboratories, has received a $4.75 million buy-out offer from New Jersey-based Cancer Genetics,
GSK to utilize genomics data, services from Metabolon
Triangle-based Metabolon, which recently struck a deal with DNA pioneer Craig Venter to help us find ways to live longer, has another high-profile partner: GlaxoSmithKline. The two neighbors disclosed a new collaboration agreement Tuesday.
Drug giant Baxter acquires Chapel Hill firm for $70M
Baxter International is acquiring Chapel Hill-based Chatham Therapeutics to gain control of gene-based therapy technology focused on hemophilia. The deal includes a $70 million upfront payment. Additional payments could be made based on development, regulatory and commercial milestones.
On Human Genome Project anniversary, NHGRI's Green sees Big Data bottlenecks ahead
National Human Genome Research Institute Director Eric Green recognizes the progress made since the first human genome was sequenced 10 years ago. Read about the Big Data challenges he sees ahead.
Vivek Wadhwa: A story about the $32,000 startup sold for millions
I meet entrepreneurs all over the world who think that venture capital is a prerequisite for starting a company. They write business plans and ask for introductions to venture capitalists. I tell them that they should instead bootstrap their startups; that what would have cost millions of dollars a few years ago now costs thousands. This story is about one startup that bootstrapped, rebooted and sold for millions.
Vivek Wadhwa: Humans have become software; amazing advances lie ahead
Opinion: Hardly a week goes by without the announcement of a major scientific breakthrough in genomics. This means that medicine will, within a few years, start advancing at the same pace as the Internet and software. And, we will see a revolution in health care.
Genome pioneer Craig Venter launches DNA firm aiming to help us all live to be 100
J. Craig Venter, the man who raced the U.S. government to sequence the first human genome, has a new goal: Help everyone live to 100, in good health. And one of his first partners is RTP-based Metabolon, where he serves as a scientific adviser.
RTP's Metabolon to help genome pioneer Craig Venter find ways to help us live longer
Metabolon will utilize its proprietary molecular technology to help Human Longevity Inc., the new company led by genome pioneer Craig Venter, to find indications of disease and gene mutations.
$5.3M grant to fund expansion of RTI genomic testing tools
A grant from the National Human Genome Research Institute will enable RTI International to enhance genomic research through its no-cost PhenX Toolkit.
N.C. Biotech Center celebrates investment trifecta
The N.C. Biotech Center notes recent wins of three Triangle life science firms whose start included support from the Biotech Center
Life sciences veteran named Gentris' new president
CED panel to explore how healthcare changes affect medtech companies
Analysis: At the CED Life Science Conference 2013, we will address the changes, challenges and opportunities in the medical device industry and study working models of successful medtech businesses.
RTP genomics firm Metabolon lands deal renewal with Syngenta
Metabolon and Syngenta have renewed an agreement through which Metabolon provides biochemical profiling technology to the agribusiness giant.
State of life science in N.C.: 'Highs' mixed with 'lows'
Throughout a day-long program, business leaders reflect on the "highs" wrought by the unique collaborative environment permeating North Carolina's life-science community, to the "lows" of an uncertain global economic and regulatory climate.
Quintiles acquires RTP-based genomics testing firm
The deal advances Quntiles' efforts to advance personalized medicine, the company says. Expression Analysis recently won a $27 million contract with the EPA.
RTP genomics firm Metabolon buys California company
Metabolon adds lipids capabilities in deal for Lipomics Technologies. Its top executive becomes CTO at Metabolon.


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With the sail away of the Cygnus Alpha Compression Module (ACM) yesterday evening the last of four main structures left Heerema Hartlepool, part of Heerema Fabrication Group (HFG) after two and a half years of construction. The Cygnus Bravo Wellhead Platform (BWHP) and the Cygnus Alpha Process & Utilities (APU) topside left earlier to the final offshore destination in the Southern North Sea. The key infrastructure, being the Cygnus Alpha Wellhead Platform (AWHP), sailed already in May 2014.
The Cygnus field consists of two drilling centres, the Alpha and Bravo. Heerema Hartlepool received the frame agreement from operator GDF SUEZ E&P UK Ltd (part of ENGIE Group) in August 2012 for the construction of three topsides, a compression module, with two bridges to connect the three Alpha platforms and a flare tower for the Cygnus field.
Koos-Jan van Brouwershaven, Chief Executive Officer of the Heerema Fabrication Group (HFG), said: "Within a period of two and a half years we have successfully delivered three topsides and a module from our Hartlepool yard. Alpha Wellhead was built first and the other structures were built simultaneously. The successful completion of such a large-scale project is due to committed teamwork with our client GDF SUEZ E&P UK Ltd. During the fabrication of the topsides we implement the design changes. This shows the strength and flexibility of our organisation when it comes to building complex structures. During the peak period of this project over 2000 people worked on our Hartlepool yards, where we successfully finished the project safely without major incidents."
The APU platform is the largest one in the Cygnus field. It is 65x35x25 metres in size and weighs about 4,600 tonnes. The APU platform receives the gas from the Alpha and Bravo Wellhead platform and optimizes the gas to prepare for transportation through a pipeline to the Bacton gas terminal onshore. Once the APU is installed the ACM module, with the 25 metres tall flare boom, will be incorporated on top of the APU topside.
The BWHP, an unmanned Satellite platform, is 42x25x13 metres in size and weighs approximately 3,200 tonnes and is situated circa 7 km from the main hub. The BWHP will be operated remotely from the APU platform. Maintenance and other personnel can reach the platform by helicopter.
Heerema Fabrication Group
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Welcome to the 2014-2015 school year! This year will be full of fun with students learning, growing, and challenging themselves everyday here is room 8!
My name is Kelly Fitzgerald-DImsho and I am excited and honored to be a part of the third grade team here at Taylor Mountain. This is my sixth year teaching. I look forward to the new curriculum in third grade including science, social studies, and art.


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- Trending Now: More Trending:
- Svengali syzygy hegemon repugnant white nationalist, white supremacist
Definition of Caryophyllaceae
: a large widely distributed family of herbs or occasionally subshrubs (order Caryophyllales) usually with stems swollen at the nodes and opposite linear leaves and with symmetrical pentamerous or tetramerous flowers that have distinct stamens as numerous or twice as numerous as the sepals
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Origin and Etymology of caryophyllaceae
New Latin, from 2Caryophyllus, type genus + -aceae
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Admiral #W10403282 Washer Switch, Pressure Assembly
Buy this residential Admiral part #W10403282 replacement washer Switch, Pressure Assembly here online at PWS Laundry the #1 Admiral washer repair parts supplier. We offer shipping specials on all Residential Admiral Laundry Parts
- Genuine Admiral Part #:W10403282
- Replaces the following Part #: W10379551
- Laundry Machine Type: Residential Washer
- Admiral OEM Description: Replacement SWITCH, PRESSURE ASSEMBLY
- Admiral Parts
- This part has been replaced by: WPW10403282
- New
Shipping Information
- Item Requires Shipping
- 1.0 lbs.
- W8.0000" x H6.0000" x L7.0000"
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Men's grey heathered cotton T-shirt with vented side seams from cult French label A.P.C. Crafted from pure cotton and cut with a straight fit, the tee features a ribbed crew neck, short sleeves and a straight hem. Complete with tonal A.P.C. branding embroidered to the hemline.
100% Cotton
Model is 188cm/6'2" and wears a size M.


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- Description
A great men's shirt is all about the fabric. Horny Toad's organic cotton Puckertwill adds life, dimension and flavor to a very subtle weave. The Mixologist Mens shirt has inherent puckers which aren't extreme but do encourage some texture plus they forever eliminate the need to iron.
Fabric : Puckertwill - 99% organic cotton / 1% spandex
- Additional Information
Additional Information
Material Cotton
- Reviews


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Foundations A-B Classroom Teacher Set
A Complete Reading and Phonics Curriculum
Ages 4-7
All the teacher materials needed to start teaching Foundations!
NEW SET! Now includes Whistling Whales: Beyond the Sounds of ABC
Provide your students with a fun, multi-sensory experience learning to read and write that engages their senses, works naturally with their desire to wiggle and play, and lays a strong foundation for reading and writing success.
This set includes one copy of each Teacher's Manual for A and B, teacher copies of the Student Workbooks, and the teacher supplements used throughout Foundations. Add the consumable workbooks and reusable student supplements and you are ready to teach Foundations!
Recommended for
- Kindergarten teachers starting Foundations with their students.
- Some 1st Grade teachers starting Foundations with their students. Learn more about where to begin.
- Early readers ready to learn more about how English words work
- Struggling readers
- Students with dyslexia
What is Included?
- Foundations A Teacher's Manual
- Foundations B Teacher's Manual
- Foundations A Student Workbook (teacher copy) - either Cursive OR Manuscript
- Foundations B Student Workbook (teacher copy) - either Cursive OR Manuscript
- Foundations B Readers (teacher copy)
- Doodling Dragons: An ABC Book of Sounds
- Whistling Whales: Beyond the Sounds of ABC
- Basic Phonogram Flash Cards
- Rhythm of Handwriting Quick Reference - either Cursive or Manuscript
- Rhythm of Handwriting Tactile Cards - either Cursive or Manuscript
- Phonogram & Spelling Rule Quick Reference
- Spelling Analysis Card
What Else Will I Need?
Reusable Student Materials
- Bookface Phonogram Game Cards (one per group of four students)
- Cursive or Manuscript Phonogram Game Cards (one per group of four students)
- Phonogram Game Tiles (one per student, or to share with a partner)
- Student Whiteboard (one per student)
- Foundations B Readers (one set per student, or to share with a partner)
Student Consumables
- Foundations A Student Workbook (one per student)
- Foundations B Student Workbook (one per student)
You may also order all the items in this set plus all the supplements and consumables for 20 students in our Foundations A-B Complete Classroom Starter Set - save 10%!
Ordering Information
- The Foundations A and B Teacher's Manuals include instructions for teaching BOTH manuscript and cursive. Foundations A and B workbooks and several of the supplements are sold in TWO versions: manuscript or cursive. Choose the version of this set that matches the handwriting style you are teaching. Learn why we recommend cursive!
- This set may also be used by first grade teachers wanting to review level A before starting B. To continue with C, you will only need to add the Foundations C Teacher's Manual, Student Workbooks, and Readers.
- This package is designed for classroom teachers. We also sell a Foundations A-B Complete Set designed for one-on-one and homeschool settings.
- Set weight: 12.2 lb.
- Set SKUs:
- PFABMT2 (Foundations A-B Classroom Teacher Set - Manuscript)
- PFABCT3 (Foundations A-B Classroom Teacher Set - Cursive)
Learn More
Logic of English Cursive & Manuscript School Fonts © David Occhino Design.
We Also Recommend


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Current Theme: Standard
Current Size: 100%
The FDA has approved an artificial implant, called Argus 11, to restore some sight to people with retinitis pigmentosa. A special pair of glasses is outfitted with a video camera and a video processing unit that sends signals to a wireless receiver implanted in the eye. "To restore vision, signals from the camera are sent to the retina, where they travel to the optic nerve in the brain.
A presentation at the American Academy of Ophthalmology meeting highlights a study showing that people with moderate vision loss could increase their reading speed by 15 words per minute by using a digital tablet with a back lit screen. This improves contrast sensitivity. "Patients with the poorest vision- defined as 20/40 or worse in both eyes- showed the most improvement in speed when using an iPad or Kindle, compared with print." The study was conducted at Robert Wood Johnson Medical School in New Jersey.
UC Davis Medical Center surgeons implanted a telescope in the eye of a patient with end-stage AMD. The device was FDA approved in 2010. The recipient is the first of 50 individuals scheduled to receive the implant. Results were encouraging. The patient said "I can see better than ever now. Colors are more vibrant, beautiful and natural, and I can read large print with my glasses. I haven't been able to read for the past seven years." The implant is smaller than a pea.
The FDA approved injection Eylea (afilbercept), formerly called VEGF Trap-Eye, has been shown to be as effective as Lucentis for treatment of AMD, according to a 96-week study of 2,412 patients, conducted by Regeneron Pharmaceuticals. After a 3 month period of once a month dosing, Eylea can be given every 8 weeks, resulting in half as many injections as Lucentis. Sales have climbed considerably.
An important step in treating AMD and preventing further deterioration is tracking its progress. A new app from iTunes allows iPhone, iPod Touch and iPad users to download the free app SightBook. It monitors vision changes by testing the users visual acuity, color vision and contrast sensitivity. Audio instructions accompany each test. The results are then sent to the patient's ophthalmologist. He must be a member of the DigiSight team. Registration can be completed on the app or at digisight.net.
The Apple iPhone has an app (app = application, or a small program), LookTel Recognizer, available in the iTunes App Store, that allows visually impaired users to recognize items and surroundings. You point the iPhone camera and listen to the phone. The phone recognizes and identifies the object or location. There is no need to hold the camera still or take a photo.
Three successful cases of treatment with an oral "nutriceutical" were reported at the annual Association for Research in Vision & Ophthalmology meeting in Florida. These patients had exhausted all other treatments, "making them candidates for this rescue medicine."
A number of developments offer hope for future treatment of macular degeneration. The FDA granted fast track designation for squalamine eye drops for the treatment of wet AMD.
Congress has appropriated $12 million in funding to support the IRS Volunteer Income Tax Assistance Program (VITA). Grants were given to organizations that will offer free tax preparation services to the elderly and disabled. To qualify, your income should be below $50,000. The toll free number for locations on tax counseling and income tax assistance is 800-906-9887.
A statement issued on February 14th, by the FDA, warns patients and health professionals that a counterfeit version of Avastin 400 mg may have filtered down to some medical practices in the United States. The counterfeit version does not contain the medicine's active ingredient, bevcizumab, which is needed for AMD therapy. The FDA informs doctors that the counterfeit version has a Roche label, and batch numbers and expiration dates inconsistent with Genetech's approved format.
Copyright © 2010 Macula.org, All rights reserved.


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-texted a girl I met off a dating site for a month now
-2 weeks into it she says she really wants to be with me, and I respond the same.
-I noticed however recently (3 weeks into it) she updated her profile and I confronted her on why if she says she wants to be with me, I got a little angry with her because I was hurt and felt a bit betrayed and she got sad and apologized
-I looked past it and all was normal. we eventually met up for the first time and everything was awesome and we had serious chemistry.
- I notice sometimes I text her and get no response. she'll respond "sorry I was sleeping" but I noticed she was reblogging on her tumblr
- I brought that up to her and she said "sorry I didn't think its a big deal" and I say "yeah I agree its not, so why would you lie about being asleep? why not say you missed the text or something?" and she said she's sorry and doesn't know
anyway I don't know what to do. I've trusted a lot of people only to get f*cked over and I kinda see this as little red flags pointing to something major. thoughts?
- over reactingVote A
- dont trust herVote B
- other (post what)Vote C
Most Helpful Girl
Red flags from you maybe. You're way too intense. Wow so she didn't feel like jumping up and replying to you straight away, big deal. Everything moving to fast aswel, 2 weeks is too soon, then you're getting angry after 3 because she updated her profile. It's all too much. She could be looking elsewhere now.00|00|0


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BROOKLYN, NY - A New York federal judge on April 28 affirmed a magistrate judge's report recommending that a Russian company's motion to confirm an arbitration award in its favor issued by the International Commercial Arbitration Court at the Chamber of Commerce and Industry of the Russian Federation (ICAC) be granted (Rushotel Limited Liability Company v. Eagles of USA Inc., No. 11-CV-267, E.D. N.Y.; 2011 U.S. Dist. LEXIS 46090).
Full story on lexis.com


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Gustav Fechner
Personality Number 9
Gustav Fechner was a male celebrity.
He was born on Sunday April 19th 1801, in Gross Sarchen, Germany.
Gustav Fechner has an impressive and aristocratic bearing. No matter how tall he is, Gustav appears noble and upright. He is very much in control of the image he sends out to others.
Many actors, dancers, and other performers have a 9 Personality number. Fechner is elegant, graceful, and charismatic. Many admire him.
Gustav Fechner has the kind of stature that pulls people to him or repels them intensely. Some are jealous of Gustav and may seek to belittle him.
Gustav may encourage this to some extent by the amount of arrogance he radiates. This is a caution for all 9 Personalities - they are sometimes aloof and hold themselves above the world. Fechner's challenge is to come down to earth with his fellow man.
Conversely, Gustav Fechner has a great compassion for humanity and he wants to dedicate himself to improving the lot of others. He is better when dealing with the trials of the many than the trouble of a single person. Gustav is more capable of working on the grand scale, addressing the needs of society, than on a one-to-one basis.
Fechner is kind and sympathetic, helpful and compassionate. Behind the controlled and calm facade, he is sensitive, vulnerable and emotional.
Gustav Fechner has excellent taste. There is a good deal of artistic talent in him that shows in his home environment and his clothing.
Gustav Fechner tends to see himself as a guardian of society, a benevolent leader, guiding and directing his community toward a better world.
You and Gustav
About Gustav's Personality number
Fechner's Personality number often serves as a censoring device, both in terms of what Gustav sends out, as well as what he allows to approach.
It discriminates in the kinds of people and information Gustav Fechner lets enter his heart and mind.
Read more about our numerological interpretation of Gustav Fechner's personality


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|Bagrati Cathedral and Gelati Monastery*
|UNESCO World Heritage Site
|State Party
|Europe and North America
|Inscription history
|1994 (18th Session)
|* Name as inscribed on World Heritage List.
** Region as classified by UNESCO.
The Monastery of Gelati is a monastic complex near Kutaisi, Imereti, western Georgia). It contains the Church of the Virgin founded by the King of Georgia David the Builder in 1106, and the 13th-century churches of St George and St Nicholas.
The Gelati Monastery for a long time was one of the main cultural and intellectual centers in Georgia. It had an Academy which employed some of the most celebrated Georgian scientists, theologians and philosophers, many of whom had previously been active at various orthodox monasteries abroad or at the Mangan Academy in Constantinople. Among the scientists were such celebrated scholars as Ioane Petritsi and Arsen Ikaltoeli.
Due to the extensive work carried out by the Gelati Academy, people of the time called it "a new Hellas" and "a second Athos".
The Gelati Monastery has preserved a great number of murals and manuscripts dating back to the 12th-17th centuries. The Khakhuli triptych had also been enshrined at Gelati until being stolen in 1859.
In Gelati is buried one of the greatest Georgian kings, David the Builder (Davit Agmashenebeli in Georgian). In 1994, Gelaty Monastery was recognized by UNESCO as a world heritage site.
- Demetre I of Georgia
- David IV of Georgia
- Solomon I of Imereti
- Solomon II of Imereti
- George III of Georgia
- Vakhtang II of Georgia
- Bagrat VI of Georgia
- George V of Georgia
- Alexander II of Imereti
- George of Chqondidi
See also
Template:World Heritage Sites in Georgia Adapted from the Wikinfo article Gelati Monastery by Levan Urushadze, licensed under the GNU Free Documentation License.
External links
|Wikimedia Commons has media related to: Gelati Monastery
Coordinates: 42°17′50″N 42°45′40″E / 42.29722°N 42.76111°E
cs:Klášter Gelatieo:Monaĥejo Gelatios:Гелаты моладзандонka:გელათის მონასტერი mn:Гелат хийдja:ゲラティ修道院ru:Гелатский монастырь sk:Kláštor Gelati fi:Gelatin luostari sv:Gelatiklostret vi:Tu viện Gelati


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Effects of Selective Estrogen Receptor Modulators on Cognitive Aging: Cognition in the Study of Tamoxifen and Raloxifene
Recent reports indicate that hormone therapy (HT) may have a protective effect on the aging
brain. Although previous studies have examined the effects of HT on age-related cognitive
changes, there is little information on the effect of a new class of estrogenic agents,
selective estrogen receptor modulators (SERMs), on cognitive aging. The two most commonly
prescribed SERMs are tamoxifen, for treatment and prevention of breast cancer, and
raloxifene, for maintaining bone density. In the face of potential widespread use of SERMs
in healthy women, information on the effects of these agents on memory and other cognitive
functions is essential.
The principal goals of Co-STAR are to compare the effects of tamoxifen and raloxifene
- on age-associated declines in measures of verbal and nonverbal memory in women over age
- other cognitive abilities and mood
- with those resulting from more common forms of HT, specifically ET (conjugated equine
estrogen) and ET plus progesterone
Co-STAR results will be compared to results from the Women's Health Initiative Study of
Cognitive Aging (WHISCA), a study involving 6-year longitudinal assessment of cognitive
outcomes in 2969 women randomly assigned to receive active treatment (Premarin or Premarin
plus medroxyprogesterone acetate) or placebo. A comparison of the Co-STAR treatment groups
with the group of WHISCA participants receiving placebo will provide insights into the
effects of SERMs relative to no treatment. A comparison of the Co-STAR treatment groups
with WHISCA treatment groups receiving ET or ET plus progesterone will provide insights into
the effects of SERMs relative to common HT treatments.
Co-STAR participants will be recruited from The National Cancer Institute's (NCI) Study of
Tamoxifen and Raloxifene (STAR), a multi-center, 5-year, randomized clinical trial among
22,000 women at increased risk for breast cancer, to compare the effects of tamoxifen and
raloxifene on risk for breast cancer.
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Prevention
California Verbal Learning Test (CVLT)
Baseline and annually up to 4 years post treatment
Sally A. Shumaker, PhD
Principal Investigator
Wake Forest University
United States: Federal Government
October 2001
March 2008
|Arizona Cancer Center
|Tucson, Arizona 85724
|Fred Hutchinson Cancer Research Center
|Seattle, Washington 98109
|Rush-Presbyterian-St. Luke's Medical Center
|Chicago, Illinois 60612
|University of Rochester Cancer Center
|Rochester, New York 14642
|Genesys Hurley Cancer Institute
|Flint, Michigan 48503
|Marshfield Clinic
|Marshfield, Wisconsin 54449
|Marquette General Hospital
|Marquette, Michigan 49855
|Cancer Research for the Ozarks
|Springfield, Missouri 65807
|Vassar Brothers Hospital
|Poughkeepsie, New York 12601
|Joe Arrington Cancer Research and Treatment Center
|Lubbock, Texas 79410-1894
|Boston Medical Center
|Boston, Massachusetts 02118
|Hartford Hospital
|Hartford, Connecticut 06102-5037
|Michigan State University
|East Lansing, Michigan 48824
|William Beaumont Hospital
|Royal Oak, Michigan 48073
|Riverview Medical Center
|Red Bank, New Jersey 07701
|Via Christi Regional Medical Center
|Wichita, Kansas 67214
|St. John Hospital and Medical Center
|Detroit, Michigan 48236
|Palmetto Richland Memorial Hospital
|Columbia, South Carolina 29203
|Thompson Cancer Survival Center
|Knoxville, Tennessee 37916
|York Cancer Center
|York, Pennsylvania 17403
|Wilford Hall Medical Center
|Lackland Air Force Base, Texas 78236-5300
|Duluth Clinic
|Duluth, Minnesota 55805
|City of Hope National Medical Center
|Los Angeles, California 91010
|Cape Fear Valley Medical Center
|Fayetteville, North Carolina 28302-2000
|Cancer Centers of the Carolinas
|Greenville, South Carolina 29605
|Lima Memorial Hospital
|Lima, Ohio 45804
|Fulton County Health Center
|Wauseon, Ohio 43567
|Penrose Cancer Center
|Colorado Springs, Colorado 80933
|Carle Cancer Center
|Urbana, Illinois 61801
|Saint Joseph Mercy Hospital
|Ann Arbor, Michigan 48106
|Ellis Fischel Cancer Center
|Columbia, Missouri 65203
|Spartanburg Regional Medical Center
|Spartanburg, South Carolina 29303
|Washington Cancer Institute
|Washington, District of Columbia 20010
|Genesis Medical Center
|Davenport, Iowa 52804
|Community Hospital
|Munster, Indiana 46321
|St. Luke's Hospital
|Duluth, Minnesota 55805-2193
|Genesys Regional Medical Center
|Grand Blanc, Michigan 48439-8066
|Presbyterian Hospital
|Charlotte, North Carolina 28233-3549
|Ochsner Cancer Institute
|New Orleans, Louisiana 70121
|Good Samaritan Health Systems
|Kearney, Nebraska 68847
|Glendale Memorial Hospital Comprehensive Cancer Center
|Glendale, California 91204
|Valley Tumor Medical Group
|Lancaster, California 93534
|North Valley Breast Clinic
|Redding, California 96001
|Southeastern Medical Oncology Center
|Goldsboro, North Carolina 27534
|Presbyterian Hospital of Dallas
|Dallas, Texas 75231
|Baylor Medical Center at Garland
|Irving, Texas 75061
|Duke University Medical Center
|Durham, North Carolina 27710
|Swedish Medical Center
|Seattle, Washington 98122-4307
|Berkshire Hematology Oncology, P.C.
|Pittsfield, Massachusetts 01201
|Henry Ford Health System
|Detroit, Michigan 48202
|University of Texas M. D. Anderson Cancer Center
|Houston, Texas 77030
|Lakeland Regional Cancer Center
|Lakeland, Florida 33805
|Southwest Cancer Center
|Lubbock, Texas 79415
|Blumenthal Cancer Center
|Charlotte, North Carolina 28203
|Cancer Resource Center
|Lincoln, Nebraska 68510-4844
|Methodist Hospitals of Dallas
|Dallas, Texas 75203
|Virginia K. Crosson Cancer Center
|Fullerton, California 92835
|Ventura County Hematology-Oncology Specialists
|Oxnard, California 93030
|Danville Hematology & Oncology, Inc.
|Danville, Virginia 24541
|Wake Forest University School of Medicine
|Winston-Salem, North Carolina 27157-1023
|Colorado Cancer Research Program
|Denver, Colorado 80224
|Sioux Valley Clinic Oncology
|Sioux Falls, South Dakota 57104
|The Hospital of Central Connecticut
|New Britain, Connecticut 06050
|McLaren Regional Medical Center
|Flint, Michigan 48532
|Grand Rapids Clinical Oncology Program
|Grand Rapids, Michigan 49503
|Missouri Baptist Medical Center
|Saint Louis, Missouri 63131
|Gaston Memorial Hospital
|Gastonia, North Carolina 28054
|Margaret R Pardee Memorial Hospital
|Hendersonville, North Carolina 28791
|Columbia River Oncology Program
|Portland, Oregon 97225
|Great Falls Clinic, LLP
|Great Falls, Montana 59405
|Forsyth Regional Cancer Center
|Winston-Salem, North Carolina 27103
|Hematology-Oncology Associates of CNY
|East Syracuse, New York 13057
|Christiana Care Health Services
|Newark, Delaware 19713
|Scott and White Hospital
|Temple, Texas 76508
|East Carolina University
|Greenville, North Carolina 27858
|Roper Hospital
|Charleston, South Carolina 29401
|Benaroya Research Institute at Virginia Mason
|Seattle, Washington 98101
|Toledo Community Hospital Oncology Program
|Toledo, Ohio 43617
|The Harry and Jeanette Weinberg Cancer Institute at Franklin Square
|Baltimore, Maryland 21237
|Huntsman Cancer Institute at the University of Utah
|Salt Lake City, Utah 84112
|CCOP Western Regional
|Phoenix, Arizona 85006
|Naval Hospital Camp Pendleton
|Camp Pendleton, California 92055
|Hematology Oncology Consultants
|Duarte, California 91010
|Southern Nevada Cancer Research Foundation
|Duarte, California 91010
|Kaiser Permanente Division of Research
|Oakland, California 94612
|Naval Medical Center San Diego
|San Diego, California 92134
|Kaiser Permanente Oncology Research
|San Diego, California 92120
|Cancer Foundation of Santa Barbara
|Santa Barbara, California 93105
|Kaiser Permanente, Woodland Hills
|Woodland Hills, California 91367
|St. Mary-Corwin Medical Center
|Pueblo, Colorado 81004
|Lawrence & Memorial Hospital
|New London, Connecticut 06320
|H. Lee Moffitt Cancer Center and Research Center
|Tampa, Florida 33612
|Memorial Medical Center
|Savannah, Georgia 31403
|University of Hawaii, Honolulu
|Honolulu, Hawaii 96813
|SwedishAmerican Hospital Regional Cancer Ctr
|Rockford, Illinois 61104
|Center for Cancer Care at Goshen Health Systems
|Goshen, Indiana 46526
|CCOP,Northern Indiana Research Consortium
|South Bend, Indiana 46601
|Finely Hospital, Wendt Regional Cancer Center
|Dubuque, Iowa 52001
|Oakwood Healthcare System
|Ann Arbor, Michigan 48106
|Battle Creek Health Systems
|Battle Creek, Michigan 49016
|Kalamazoo, Michigan 49007
|Mercy Memorial Hospital Cancer Center
|Monroe, Michigan 48162
|Hennepin Consortium
|Minneapolis, Minnesota 55415
|St. Louis Park, Minnesota 55416
|Hematology & Oncology Associates Ltd
|Tupelo, Mississippi 38801
|St John's Regional Medical Center Cancer Center
|Joplin, Missouri 64804
|St John's Health System
|Springfield, Missouri 65804
|Alvin J Siteman Cancer Center at Barnes-Jewish Hosp & Washington U Sch of Med
|St. Louis, Missouri 63110
|Montana Cancer Consortium
|Billings, Montana 59101
|Missouri Valley Cancer Consortium
|Omaha, Nebraska 68106
|Methodist Cancer Center, Omaha
|Omaha, Nebraska 68114
|Roswell Park/Western New York STAR Consortium
|Buffalo, New York 14263
|Bassett Healthcare
|Cooperstown, New York 13326
|University Healthcare System
|Syracuse, New York 13202
|Kaiser Permanente Ohio
|Bedford, Ohio 44146
|Ireland Cancer Center at Case Western Reserve University
|Cleveland, Ohio 44106
|CCOP Columbus
|Columbus, Ohio 43215
|Kaiser Permanente Center for Health Research (Oncology Research)
|Portland, Oregon 97227
|UPMC/UPCI/Magee Women's Hospital
|Pittsburgh, Pennsylvania 15213
|Mercy Cancer Center, Scranton
|Scranton, Pennsylvania 18501
|Don and Sybil Harrington Cancer Center
|Amarillo, Texas 79106
|Baylor-Sammons Cancer Center
|Dallas, Texas 75246
|UT Southwestern Center for Breast Care
|Dallas, Texas 75390
|Breast Care Center at Baylor College of Medicine/Methodist Hospital
|Houston, Texas 77030
|Baylor Regional Medical Center
|Plano, Texas 75093
|Olympic Hematology and Oncology Associates
|Bremerton, Washington 98310
|Yakima Valley Memorial Hospital/North Star Lodge Cancer Center
|Yakima, Washington 98902


text:
Orientation Week, or O-Week, began in 1934 as a way to introduce a new class of students to the traditions and community that has made the University of Chicago a unique destination for students from around the world. This eight-day series of events, programs, and meetings provides new students with an in-depth overview of how the College works. Important parts of O-Week include registration for classes, overviews of the various academic disciplines, and meetings with faculty, academic advisers, and fellow students. This year's O-Week begins on Saturday, September 16, 2017 with residence hall move-in and continues through Saturday, September 23, 2017. Parents and families are invited to join in the festivities on Saturday, September 16th and Sunday, September 17th. For more information about events for parents and families, see the Information for Parents and Families section of this website.
O-Week, however, isn't all business. We have a lot of fun too. During the week, students explore the city of Chicago, the neighborhood of Hyde Park, and get to know the other students in their College House. Your journey through O-Week will be guided by our amazing staff of O-Aides, current students who will assist you with everything from moving into your Residence Hall to registering for classes. If you have any questions throughout the course of the week, feel free to ask one of the O-Aides or contact the College Programming Office.
The information in this section of the website is designed to provide you with an overview of O-Week, including access to our O-Book mobile app (available in mid-September), your schedule and guide through Orientation Week. Keep checking back throughout the spring and summer for updates and additional information about Move-In & Opening Day, Class Day, and more.


text:
Me -
- fixing things.
- eating things/going out for dinner.
- riding my motorcycle, and sometimes a bicycle.
- watching the stars
- fires
- exploring places/abandoned buildings?
- people watching/general observing.
- jiu jitsu
- I like TV too, what can i say.
Sports? Meh.
And then there is this
Finding that one weird dude in the crowd.
Using my senses, especially my nose (aspiring smell detective)
Instantly finding the word pizza in a page of words.
Being punctual.
Arrested development, Parks and Rec, Top Gear, Peep Show, Star Trek(s), anything sci-fi really.
Yes, I like music.
Pizza, Sandwiches, Tacos, Wings...you know, really healthy stuff.
Having one blank space in lists.
What's for lunch..then what's for dinner, and what is for lunch tomorrow.
What other people are thinking. Was it pickles?
But typically for me, being typical; beers with friends or doing nothing. H I P.
If you're normal and grounded, not some jet-set "oh this is me in South East Asia swaddling a baby orangutan" travelista. Cool, you have money...we get it . You're cute and want to eat some pizza, or tacos, or pizza tacos and go for a motorcycle ride, explore an abandoned building...or play some darts? Drink some beers?
You get this http://vimeo.com/5263975


text:
Download India's Independence Day apk 2.3 free for Android smartphone
Posted by bharatformobile in Books & Reference | July 29, 2016 | 1 Comments
Apk file size: 4.7 MB
Welcome to India's Independence Day For Android!
This application holds 8 Patriotic Songs Written for Bharat (Mother India).
India's Independence Day is on August 15th! Take time out and get to know these patriotic songs!
We hope you like this application as much as we have liked making it! Email us at [email protected] if you have any other additional patriotic songs you want us to add!
Tags: Independence, Day, Independence Day, India, Bharat, Jana Gana Mana, National Anthem of India, National, Song of India, National Song of India, Sare Jahan Se Aacha, Bharat humko jaan se pyara hai
Whats new
bharatformobile Update
*Major Bug Fixes to make your reading experience much more smooth!
bharatformobile part of our Books & Reference and have average installs from 1000 to 5000. Last Update July 29, 2016. Google play rating is 86.25. Current verison is 2.3. Actual size 4.7 MB.
Similar applications
1 Comments
Arvind Chauhan
I love my india


text:
kfm Productions
kfm Productions (30 / 03 / 1987)
» Click to list general statistics » OR, select a date :
I Don'T Trust Anyone...
The fact is i don't trust anyone,
hence i have been used by my father...
read more >>
- Hits: Number of visitors who read the poem on the given date.
- Posts: Number of visitors who posted the poem to a friend (via e-mail) on the given date.
- Dates that have "0" hits may not be shown on the list.
- Dates, poems and poets that have "0" hits may not be shown on the list. Statistics are generated daily.


text:
Introducing the 30ml ZampleBox! $4.91 per 30ml bottle!Get started
I was super bummed about this one. Prior to trying it, the description had me really excited. The idea of coconut with citrus-y flavors got me excited. Once I tried it, it essentially tasted like key-lime pie. Not a horrible flavor mind you, just didn't really seem to match the description and was not the flavor I wanted.
Can't seem to distinguish the fruit flavours, get this sugary sour flavour on the exhale that burns the throat.


text:
Synthetic Polymers for Simultaneous Bacterial Sequestration and Quorum Sense Interference†
- †
We thank the UK EPSRC and BBSRC (Grants EP/G042462/1, EP/D022347/1, D021847/1, and BB/F01855X/1) and the University of Nottingham, UK, for funding. We thank Bonnie Bassler (Department of Molecular Biology, Princeton University) for the gift of V. harveyi strain MM32, Adrienne Davis and Shazhad Aslam (School of Chemistry, University of Nottingham) and Istvan Pelczer (Department of Chemistry, Princeton University) for help and useful discussions regarding 11B NMR spectroscopy, and Natalio Krasnogor, Leung Lui (School of Computer Sciences, University of Nottingham), and Chunjuan Liu (Department of Chemistry, University of Oxford) for helpful discussions.
Double agents: Dual-action polymers are able to sequester rapidly the marine organism Vibrio harveyi from suspension, while at the same time quenching bacterial quorum sense (QS) signals (see picture). The potency of the polymers is assessed by cell aggregation experiments and competitive binding assays against a QS signal precursor, and their effect on bacterial behavior is shown by means of bioluminescence.


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Published: 2016-10-02 18:51:00
Updated: 2016-10-02 21:27:18
Posted October 2, 2016
Fayetteville, N.C. — Last week's floods are still having an impact in some areas, including Cumberland County, which was hit hard by the storm.
In Fayetteville, Strickland Bridge Road remained closed Sunday and a Spring Hope church congregation returned to their sanctuary for the first time after the floods.
"It's just a great, loving, small church that makes you feel welcome," said church member Misty Wade.
A group gathers every week as the New Life Worship Church but this Sunday, some things were just not the same. The group now has a temporary church at Anderson Creek Christian Church after floods damage forced church members out of the building.
"We are the church. It's not the building," said Pastor Austin Swinson.
The sanctuary the group used for the past two years is now more of a storage area. Other parts of the building were still being dried out and will need extensive repair.
"We know what we've got to do now. We know what damage has been done so now we have to move forward," Swinson said
Although the floods caused a lot of damage, the church group reminded each other that their faith, determination, gratitude and faith are stronger than ever.
"We're going to be blessed and we're moving forward," Wade said.
The group had just finished paying off the church last year and are hoping to return to the building next month.
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