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Please Pray for my dear friend. She was clean for 4 1\2 years. Not sure what happened to turn her back to drugs. I am so heart broken over her bad choices. A exhusband has come back into her life. They were deep in to drugs while they were married the first time. It only took about a week and a half and they remarried after not seeing each other for over ten years. Really not sure what happened to send her into making such bad choices. Please Pray that our Dear Lord will help her to stop using the drugs and get away form the man that has helped her with her drug problem. I Pray we can get back our dear friend, daughter and mother back with us very soon.
Join in and write your own page! It's easy to do. How? Simply click here to return to Prayers for Strength.
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The Six Best Concerts in Phoenix This Week
STRFKR is scheduled to perform on Thursday, May 26, at Marquee Theatre in Tempe.
Windish Agency
Looking for a memorable show to see over the next few nights? Consider any of the following six options in our list of concert picks for this week.
As always, if you're looking for even more live music in and around the Valley, be sure to check out our comprehensive Phoenix concert calendar for even more choices for your concert-going dollar.
Pentagram's Bobby Liebling.
Denis Barthel
Pentagram – Monday, May 23 – Nile Theater
Pentagram are goddamn legends. Don't let anyone tell you otherwise. This is the band that pioneered doom metal in the '70s and '80s at a time when the mainstream world still coming to terms with what Metallica and other speed-metal bands were doing Pentagram is the creative outlet for Bobby Liebling, who has overseen the band through a slew of lineup changes throughout the years. After a number of years
spent toiling in relative obscurity, the band experienced a renaissance of sorts following the 2011 release of the documentary Last Days Here, which chronicled Liebling's addiction problems. Now the band is releasing albums and touring the country, including a stop at the Nile Theater in Mesa, which will provide the perfect confines for the heaviness Pentagram helped pioneer. DAVID ACCOMAZZO
The members of DevilDriver.
Napalm Records
DevilDriver – Monday, May 23 – Marquee Theatre
If heavy metal is at its core an angry outburst of aggression - youthful rage channeled into pummeling, loud, aggressive riffs - then what is left to fuel the fire as a band ages? DevilDriver isn't the first band to ask itself, "What do we do now?" after the initial surge of camaraderie and shared artistic drive fades into a business-driven necessity to produce an album on a once-every-two-years schedule. Dez Fafara, the former Coal Chamber singer, has headed DevilDriver since 2003 and is the only long-tenured member, with the exception of guitarist Mike Spreitzer, who joined in 2004. DevilDriver released Trust No One earlier this month, featuring two new members, drummer Austin D'Amond and guitarist Neal Tiemann. But have no fear, DevilDriver fans: This album sounds pretty much exactly like every other DevilDriver album out there, which leads us to one question: When does a band become an assembly line, where the product supersedes the contributions of its individual members? DAVID ACCOMAZZO
Mayer Hawthorne
Jake Michaels
Mayer Hawthorne — Tuesday, May 24 — Crescent Ballroom
Andrew Mayer Cohen, aka Mayer Hawthorne, approaches his music with the same zest as his culinary cravings. As a DJ, producer, singer, and songwriter, he reaches into various genres of music, but finds himself pulled back into soul every time. As a young kid, he performed as Michael Jackson for his family, sequined white glove and all. As an adult, his work with other artists he's looked up to, such as Pharrell Williams (on 2013's Where Does This Door Go), and Memphis soul legend Booker T. Jones, has helped him explore the depths of his own soul. His recently released album, Man About Town, which dropped in April on Vagrant Records, gets deeply personal on topics of love, loneliness, and heartbreak in the City of Angels. MICHELE MCMANMON
Tyler, The Creator
Courtesy photo
Tyler, the Creator — Wednesday, May 25 — Marquee Theatre
Tyler, the Creator is undoubtedly a crass man-child afflicted with arrested development. To him, a casual chat — perhaps over tea and crumpets — about sex, class, and religion must sound like a literal nightmare or a concoction fashioned by Rod Serling. He's yet another dude in a line as long as the lunch rush at the DMV who's an asshole that should be punched in the throat for his personality. But he should at least also be given a bag of ice and a shoulder rub for his art. Tyler is rap music's Peter Pan: He refuses to grow up, except musically perhaps, and his sole purpose is aimless fun.
His latest album, Cherry Bomb, has the rooted and recognizable workings of a Tyler, the Creator album. There's a whole bunch of N.E.R.D., Pharrell Williams, and the Neptunes fan fiction. It's loud and poorly mixed in spots because he just thinks it sounds better that way, bro. But there are flashes of a man all grown up, particularly when he hunkers down on the production and gets jazzy. You can expect this to be a rowdy show, as Tyler is the James Warren "Jim" Jones of the cult of rowdy for no-reason millennial idiots. It's the hottest ticket in town for the night, and recommended if you can grin and bear it. H. DREW BLACKBURN
The members of STRFKR.
Windish Agency
STRFKR and Com Truise — Thursday, May 26 — Marquee Theatre
When STRFKR first appeared nearly a decade ago, it was hard to tell where its brand of minimal electro-pop would land. But with musical mastermind and vocalist Josh Hodges at the helm, the band soared into its own, creating breezy and sweet songs, and tracks like "German Love" and "Rawnald Gregory Erickson the Second" found homes in both the robust music blogosphere and Target commercials. Fast-forward to the present, many albums and tours later, and STRFKR is still churning out beautiful modular beats, carrying its signature bedroom-recording style more closely in line with the mainstream while managing to stay just below the surface in its own indie world. On new single "Never Ever," the band follows a tried-and-true formula of combining Hodges's sexy murmur with a throwback dance vibe — a promising sign that STRFKR won't stray far from the silky, playful sound that makes it great. BREE DAVIES
Singer/songwriter Brett Dennen.
Jimmy Fontaine
Upcoming Events
TicketsThu., Sep. 21, 8:00pm
Kenny Cetera's Chicago Experience
TicketsFri., Sep. 22, 7:30pm
Jared and the Mill
TicketsSat., Sep. 23, 8:00pm
TicketsSun., Sep. 24, 6:30pm
Fleet Foxes
TicketsSun., Sep. 24, 7:30pm
Brett Dennen – Thursday, May 26 – Crescent Ballroom
With six studio albums under his belt, including the brand-new Por Favor, Brett Dennen has fully established himself as a troubadour interested in spreading the love — and, quite specifically, not the dour. Look, there's no getting around it: The 36-year-old singer and songwriter is a glass-half-full kind of guy. Nothing wrong with that. What's interesting, though, is how Dennen can effortlessly take any subject and make it sound downright peppy. His songs thrive on that transformation: What may seem like a breezy, bare-footed tune is often detailing something deeper, something more socially conscious, or even spiritual.
"I wanted to make something that was emotional as well as thoughtful — meaning being very precise with the lyrics and the music. I wanted to keep it simple, get my point across, and have the lyrics mean different things on different levels. But also keep it very personal," Dennen stated in a recent interview regarding Por Favor. "I also wanted to have spirituality in the songwriting as well. Not just write about my personal experience but to also have a thread going through all the songs of the presence of spiritual acknowledgement of some sort." KELLY DEARMORE
Editor's note: this blog has been updated since its original publication.
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Are you losing focus of your business? Is your day schedule is too packed up which has increased your stress level? Are you not able to give 100% to your business? If yes, then it's time to think about how you can increase focus on business.
Of course stress is a part and parcel of one's life and when we talk of the modern day women, in particular, some may say stresses are in fact higher than their counterpart as the women of today aren't usually just stay at home mums.
Today's society demands the need to create a balance between work and personal life. Obviously, your kids need your time and attention too. To cater to the need of increasing mental focus in business, there are supplements you can take to help increase your "super mum powers". Enter Nootropics.
In spite of the fact that Nootropics are beginning to end up more mainstream, many people still don't know precisely what they are. Nootropics can be defined as a substance that upgrades the cognitive characteristics of the brain, just like coffee. They have been around for a long time now, and you might have beforehand heard them be alluded to as "Smart Drug". A renowned Romanian specialist named Dr. Corneliu E. Giurgea coined the term "Nootropics" in the year 1972. He made this one of a kind word by joining two diverse latin words: nous and trepein. While "nous" implies mind, "trepein" intends to twist. These two words fit the idea of nootropics flawlessly, as Nootropics can twist the brain and in this manner, build its urgent capacities, for example, the capacity to both remember and focus. Exploratory studies have demonstrated that Nootropics can help boost the normal individual's memory, certainty levels, individual inspiration, and general mind's capacity. The various benefits of these smart drugs are: better productivity, improved sleeping habits, improved emotional stability, better coordination between mind and body, reducing stress level, improvement in mood swings, and many more.
So, if you are a working woman who is dealing with stress and wants to increase focus in business, then Nootropics may just be the answer. They help to enhance the memory, learning capacity, concentration level and ability to focus which ensure you can go on being super mum!
Information sourced from the following websites:
Dr. Corneliu E. Giurgea: https://en.wikipedia.org/wiki/Corneliu_E._Giurgea
Nootropics: www.supplementreviewhq.com


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What is JotForm?
JotForm is a free online form builder which helps you create online forms without writing a single line of code. No sign-up required.
At JotForm, we want to make sure that you're getting the online form builder help that you need. Our friendly customer support team is available 24/7.
We believe that if one user has a question, there could be more users who may have the same question. This is why many of our support forum threads are public and available to be searched and viewed. If you'd like help immediately, feel free to search for a similar question, or submit your question or concern.
How does secure URL and SSL submission worksAsked by blackboxtie on July 02, 2014 at 09:21 AM
Can you please explain in further detail what this means:
"The closest you can get to the actual form appearing on your unsecured page would be an image of the said form. This is different than an embedded form which can be completed and submitted from your page even though the form doesn't actually reside there."
My page is not secured but I would like to include a secured form on there without having to link to the form. I do not want to link only to the form because it loses my website headers and navigation. Is there a workaround for this? Any help would be greatly appreciated, thank you in advance
JotForm Support Manager
That answer was meant for the specific client.
Let me tell you that in general, form data will be securely sent if you use the SSL version of the form in a non secure website.
This means that the form won't be in a secure zone, but if someone fill out your form and sent it to Jotform servers, it will be secured. (our submission servers are also protected with SSL.)
It would be advisable to use either the iFrame version or the Embed version, rather than the source code, though.
Thank you for your prompt reply!


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text: 8 photos $34,900 4 acres 330 Townhouse Road, Whitefield, ME 04353 - Lincoln County 4 acres Whitefield, ME Nice home site, 50 foot right of way access, private gravel road in, power to lot, drilled well and septic on site. Older small house beyond repair needs to be torn down, but very nice private rural home site with 300 /- feet on the Sheepscot River. Mobiles, double-wides, modular or stick built all welcome.


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FlockThere: Real-Time Location & Message Sharing For Meetups [Android]
Merging the concept of real-time location and message sharing, FlockThere is an extremely useful Android and iOS app that helps you learn of your contacts' current locations who might be on their way to attending an event. Imagine the facility of having an app at your disposal that shows the geographical position of all your invitees/guests on map, so that you know exactly where they are, and when to expect them to arrive at the event location. What's even better is that using FlockThere, you can stay in touch with all those contacts via chat messages. In short, FlockThere provides you with real-time location of your guests on map, and helps you stay apprised of their progress/journey via text messages; all info shared on the same screen. All you need to do is create and send a new Flock invitation to your contacts via the app, and start tracking them in real-time. Invitations can be sent to the contact's email ID or phone number, and the best part about the entire deal is that you can keep adding/removing participants from a Flock even after it has been created. Provided your contacts/guests are already on FlockThere, they can reply directly from within the app. Even if they do not have the app on their devices, they can still keep in touch with you via the service's web-enabled chat interface (requires internet connection of some sort).
All in all, the basic purpose of FlockThere is to free you from the hassle of tracing your guests at frequent intervals by constantly calling/texting them, or worrying about their whereabouts. Instead, the app serves the favor in fine style. To further expedite the process of staying in touch with all the participants via messaging, the app also presents you with a handful of most commonly used quick message templates, so that you don't have to waste any precious time in composing lengthy messages. If, however, you are required to convey your message in detail, there is the option for you to compose a custom message from within the app.
Although the app lets you take a glance at the location of all participants via map, there is also an option to keep your own location concealed. Moreover, the app helps you create multiple Flock groups using selected contacts, so that you can always invite a specific group of people whenever there is an event organized that involves the same contacts.
When launched, the app prompts you to log in using a valid FlockThere ID. Don't have one? You can grab a fresh account for yourself from within the app for free. Once past that, the app helps you get a grip of all the various features on offer via a couple of tutorial screens.
After that, you are taken to the app's homescreen, which presents you with a couple of tabs at the bottom, namely Invite Flock (so create and send new invitations to selective contacts), Flocks (to view your active and upcoming Flocks), and Settings (to modify the app's main preferences).
A Flock new invitation needs to be filled with all the required info, including the Flock title, start/end time, and location. While within an active Flock, you can start tracing and texting your contacts via a unified screen. The top segment of the screen is dedicated to displaying your chat messages in bubble style whereas the bottom half of the screen lets you view the current location of each participant on map via relevant placemarks. Using the tabs at the bottom of the screen, you can Locate All participants with a mere tap, send a custom/quick Message to them, and/or decide whether you wish to turn your own location Sharing On/Off.
Remember that a Flock only remains active for a user-specified time period during which you can stay in touch with the participants. The app notifies you about each new shared message via notification alerts and push notification.
Download FlockThere for Android


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Product Spotlight
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Conn. Prepares to Crack Down on Tax-Free Cigarettes
With the cigarette tax rising to $1.11 per pack, lost revenue is projected at $11.8 million.
HARTFORD, Conn. -- Connecticut's tax commissioner says the state will crack down on tax-free cigarettes sales on the Internet and through the mail, hoping to recover millions of dollars in lost revenue.
With the state's cigarette tax more than doubling next month, going from 50 cents to $1.11 a pack on April 3, the state is working with the federal Bureau of Alcohol, Tobacco, and Firearms to begin enforcing a federal law that requires mail and Internet companies to provide monthly lists of their customers. State tax officials will use those lists to locate scofflaws, according to the Hartford Courant.
So far this fiscal year, only seven out of 80 identified out-of-state vendors, including one reservation-based outfit, have filed the lists. The buyers have ended up paying more than $55,000 in taxes and fines, a paltry figure compared to an estimated $6.3 million in cigarette taxes the state will lose this fiscal year, the report said.
With the cigarette tax rising to $1.11 per pack, the lost revenue projection is $11.8 million for the fiscal year starting July 1.


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Val J. Halamandaris Honored with Home Care and Hospice "Hero Award" from the Ohio Council for Home Care & Hospice
Val J. Halamandaris, President, National Association for Home Care & Hospice (NAHC) was honored with the "Home Care and Hospice Hero Award" from the Ohio Council for Home Care & Hospice (OCHCH) at the 2013 Fall Conference & Tradeshow Annual Awards Luncheon on September 12 in Columbus, Ohio. The Home Care and Hospice Hero Award recognizes an individual who has made a significant contribution to the improvement and advancement of home care and hospice during their career.
Halamandaris is a well-respected and nationally known expert in health, aging, and long-term care. Working with home health advocates since the beginning of his career, Halamandaris served as associate counsel to the U.S. Senate Committee on Aging for nine years before becoming director of oversight and senior counsel for the House of Representatives Select Committee on Aging. In this position, he worked to preserve and extend Social Security, established a program to help stop abuses in the sale of health insurance to supplement Medicare, and removed impediments restricting use of the Medicare and Medicaid home care benefits.
Halamandaris started the National Association for Home Care & Hospice in 1982 with the mission of bringing health care back home where it belongs. NAHC is the largest and most-respected professional association representing the interests of Americans who need home care (including acute, long-term, and terminal care) and the caregivers who provide them with in-home health and supportive services.
:: Read
Full Article
The Importance of Attending NAHC's Annual Meeting & Exposition this Year
"If there was ever a year for home care and hospice managers to join us, this is the year," said Bill Dombi, Vice President for Law, National Association for Home Care & Hospice (NAHC). "Agencies across the country are faced with looming budget cuts, the possibility of more cost shifting onto beneficiaries, diminishing margins, and increasingly stringent - and often confusing - new regulations. These challenges are offset with great opportunities that we will address."
With so much at stake, this is the year to attend NAHC's Annual Meeting & Exposition October 31 – November 3 in Washington, DC.
Register today to join your colleagues in Washington and fight to preserve access to home care and hospice services.
NAHC's president, Val J. Halamandaris recently made a video updating NAHC members on developments in Washington, though urged all members to join their peers for this year's Annual Meeting given how high the legislative stakes are for the entire home care and hospice community.
In the video, available here, Mr. Halamandaris states that there is good news in the form of additional tax revenues coming into the Treasury, as well as a strong indicator that the economy is, "starting to boom."
Update on the Home Health Rebasing Dear Colleague Letter
NAHC Report recently announced that several Members of Congress circulated a Dear Colleague letter in the House and Senator Debbie Stabinow (D-MI) circulated a similar letter to her Democratic Senate colleagues regarding the proposed rebasing rule that would severely cut home care payments under Medicare.
Please take a moment to urge your lawmakers to sign-on to these important letters. Recently, the NAHC Legislative Action Network posted additional resources – including background information and a grassroots letter that NAHC members can send their lawmakers asking them to sign the letter.
The Legislative Action Network resources also include the projected impact that the rebasing rule will have on individual states and districts.
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Question: What are the essential differences among demand deposits savings deposits
What are the essential differences among demand deposits, savings deposits, and time deposits?
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Answer to relevant QuestionsWhat are primary reserves and secondary reserves, and what are they supposed to do?Suppose a bank has an allowance for loan losses of $1.25 million at the beginning of the year, charges current income for a $250,000 provision for loan losses, charges off worthless loans of $150,000, and recovers $50,000 on ...Who are banking chief competitors in the financial-services marketplace?For each of the transactions described here, which of at least two accounts on a bank's balance sheet (Report of Condition) would be affected by each transaction?What factors influence the stock price of a financial-service corporation?
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super sixes
Who doesn't love a list? These are our pick of the best events from beginner triathlons to the toughest 10k's.
A scenic 120km tour of the ancient lead mining villages of the White Peak. Changing facilities and cafe at start/finish. Starting from Chapel en le Frith, the ride heads to Castleton via Rushup Edge and Winnats Pass the easy way (downhill!) before a climb out of Hope Valley.
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Stovetop Melted Sandwich Maker
Meant to be used on a stove top. A great way to make a quick meal or delicious snack. No mess included!
How convenient! My sister would love this.Tags: gifts, food, kitchen, appliances, cooking, breakfast, eggs, toasts, Kitchen GadgetsAdded 9 Years Ago from Amazon.com
This little gadget is perfect for holding your sandwich together as you hold it on top of your stove to grill it - or you can even stick it straight into your toaster to toast the bread together without anything falling out!Tags: kitchen, grill, paninis, healthy, sandwich maker, indoor grills, indoor grills and sandwich makersAdded 9 Years Ago from Amazon.com


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Wondershare™ MobileGo iOS Mac® Does What iTunes® Won't - Lets Users Transfer Music From iPhone®, iPad®, iPod® Touch Back to iTunes; Transfers Other Content Too
New Companion Application Works with iTunes to Allow Mac Users Greater Flexibility in Transferring Content "to and from" their iDevices, alleviating a Frustration Experienced by Millions of Users
Apr 08, 2013, 12:44 ET from Wondershare Software Co., Ltd.
SAN FRANCISCO, April 8, 2013 /PRNewswire/ -- iPhone, iPad, and iPod Touch users who sync their devices to a Mac; Wondershare has a great new product for you called MobileGo iOS, and quite simply, it lets you do what iTunes doesn't - copy content from an iDevice back to the Mac. Ask just about any user who has downloaded non-iTunes purchased content to their iDevice and tries to sync it back to the Mac, or transfer content to their devices that did not come from iTunes; it doesn't really work - until now. MobileGo for iOS lets users seamlessly transfer Music content back to the iTunes library with 1-click, and allows music, movies, TV shows, Podcasts, even voice memos to be copied to the Mac. MobileGo iOS Mac is a very handy tool for "moving into" a new Mac as content can easily be migrated from the device to the Mac,
MobileGo for iOS Mac also solves another problem many users who have music and video content not purchased through iTunes have - how to correctly format and convert music and videos from different sources and be able to copy them to their iDevices so they can be enjoyed on the go. MobileGo for iOS leverages Wondershare's famous Video Converter technology to ensure the best possible playback quality perfectly formatted for the iPhone, iPad, or iPod Touch screen with no guesswork. MobileGo for iOS Mac can also help users manage their photos and albums by transferring the iDevice's camera roll back to the Mac and create/organize albums.
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Wondershare, an IDG invested company, is an innovative software developer dedicated to delivering the very best in software products and services to the worldwide consumer and business market segments. Wondershare has branch offices in the United States and Japan. Wondershare has been honored as Deloitte Tech Fast 500 Asia Pacific and China 50 for three consecutive years, and Forbes Business Potential of China for two consecutive years. For more information about Wondershare and its products, please visit http://www.wondershare.com.
Wondershare is a registered trademark of Wondershare Software Co. Ltd. Other names may be trademarks of their respective owners.
SOURCE Wondershare Software Co., Ltd.


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Use of standard adult lopinavir/ritonavir (LPV/RTV) dosing (400/100 mg) during the third trimester of pregnancy results in reduced LPV exposure. The goal of this study was to determine LPV exposure during the third trimester of pregnancy and 2 weeks postpartum with a higher LPV/RTV dose.
The Pediatric AIDS Clinical Trials Group Protocol 1026s is an ongoing, prospective, nonblinded study of antiretroviral pharmacokinetics in HIV-infected pregnant women that included a cohort receiving LPV/RTV 400/100 mg twice daily during the second trimester and 533/133 mg twice daily during the third trimester through 2 weeks postpartum. Intensive steady state 12-hour pharmacokinetic profiles were performed during the third trimester and at 2 weeks postpartum and were optional during the second trimester. LPV and RTV were measured by reverse-phase high-performance liquid chromatography with a detection limit of 0.09 µg/mL.
Twenty-six HIV-infected pregnant women were studied. Median LPV area under the plasma concentration-time curve (AUCs) for the second trimester, third trimester, and postpartum were 57, 88, and 152 µg·h−1·mL−1, respectively. Median minimum LPV concentrations were 1.9, 4.1, and 8.3 µg/mL.
The higher LPV/RTV dose (533/133 mg) provided LPV exposure during the third trimester similar to the median AUC (80 µg·h−1·mL−1) in nonpregnant adults taking standard doses. However, the AUC on this increased dose at 2 weeks postpartum was considerably higher. These data suggest that the higher LPV/RTV dose should be used in third trimester pregnant women; that it should be considered in second trimester pregnant women, especially those who are protease inhibitor experienced; and that postpartum LPV/RTV dosing can be reduced to standard dosing by 2 weeks after delivery.
Antiretroviral agents are commonly administered to HIV infected pregnant women to prevent mother-to-child HIV transmission and to maintain the health of the pregnant woman.1 Current US Public Health Service guidelines on the management of HIV-infected women during pregnancy recommend that all HIV infected pregnant women be offered treatment with a potent combination regimen to prevent HIV perinatal transmission.2 The recommended first line protease inhibitors are the combination of lopinavir and ritonavir, which is available only as the fixed dose combination formulation Kaletra.
Previous studies of the pharmacokinetics (PK) of several protease inhibitors during pregnancy have demonstrated reduced plasma drug exposure in pregnant women.3 We have recently shown that administration of Kaletra during the third trimester of pregnancy using the capsule formulation (LPV 133 mg/RTV 33 mg) at the standard adult dose of 3 capsules twice daily resulted in plasma concentrations approximately 50% of those seen in nonpregnant adults.4 The purpose of the current study was to describe LPV PK during the third trimester of pregnancy with administration of an increased dose of 4 capsules twice daily.
Pediatric AIDS Clinical Trials Group (PACTG) Protocol P1026s is a multicenter prospective study to evaluate the PK of currently prescribed ARVs among HIV-infected pregnant women. This report includes only women receiving LPV/RTV capsules at the increased dose of 4 capsules twice daily. P1026s is a substudy of P1025, a prospective cohort study of HIV-infected pregnant women receiving care at PACTG sites.
Eligibility criteria for this LPV arm of P1026s were as follows: enrollment in PACTG P1025 and initiation as part of clinical care, either standard dose LPV/RTV (3 capsules: LPV 400 mg/RTV 100 mg orally twice daily) before 26-week gestation or the increased dose (4 capsules: LPV 533 mg/RTV 133 mg orally twice daily) before the beginning of the 35th week of gestation. Exclusion criteria were as follows: concurrent use of medications known to interfere with the absorption, metabolism, or clearance of LPV or RTV and multiple gestation and clinical or laboratory toxicity that, in the opinion of the site investigator, would likely require a change in the medication regimen during the study. Local institutional review boards approved the protocol at all participating sites, and signed informed consent was obtained from all subjects before participation. Subjects continued to take their prescribed medications throughout the course of their pregnancies. The choice of additional ARVs was determined by the subject's physician, who prescribed all medications and remained responsible for her clinical management throughout the study. ARVs were not provided by the P1026s study, and the study team did not determine which ARVs were prescribed. Women continued on the study until the completion of postpartum PK sampling.
HIV-infected pregnant women receiving LPV/RTV as part of their clinical care could enroll in the study during either the second or third trimester. For women enrolling during the second trimester of pregnancy, LPV PK with the standard dose of 3 capsules (LPV 400 mg/RTV 100 mg) were determined in real time between 20- and 26-week gestation. At 30-week gestation, the LPV dose was increased to 4 capsules (LPV 533 mg/RTV 133 mg) twice a day and PK sampling was repeated between 30- and 35-week gestation. Women enrolling in the third trimester received the increased dose of 4 capsules (LPV 533 mg/RTV 133 mg) and had PK sampling performed between 30- and 35-week gestation. PK sampling on the increased dose was repeated at 2 weeks after delivery, and the dose was then reduced to the standard dose of 3 capsules (LPV 400 mg/RTV 100 mg) twice daily. LPV AUC was calculated for each woman and compared with the distribution of LPV AUC in nonpregnant adult populations taking the standard dose.5 Each subject's physician was notified of the subject's plasma concentrations and AUC within 2 weeks of sampling. If the AUC was below the 10th percentile in nonpregnant adult populations (52 µg·h−1·mL−1), the physician was offered the option of discussing the results and possible dose modifications with a study team pharmacologist.
HIV-related laboratory testing was performed as part of the parent study (P1025) and as part of routine clinical care. Maternal data from P1025 accessed for this analysis were as follows: maternal age, ethnicity, weight, concomitant medications, CD4, and viral load assay results. HIV plasma viral load assays had lower limits of detection ranging from less than 20 to less than 400 copies per milliliter. Infant data included birth weight, gestational age at birth, and HIV infection status. Maternal clinical and laboratory toxicities were assessed through clinical evaluations (history and physical examination) and laboratory assays (alanine aminotransferase, aspartate aminotransferase, creatinine, blood urea nitrogen, albumin, bilirubin, and hemoglobin) on each PK sampling day and at delivery. The study team had monthly conference calls to review each toxicity report, although the subject's physician was responsible for toxicity management. The Division of AIDS/National Institute of Allergy and Infectious Diseases Toxicity Table for Grading Severity of Adult Adverse Experiences was used to report adverse events for subjects during pregnancy and postpartum.6 All toxicities were followed through resolution.
Blood sampling was scheduled in all subjects at 3 time points: third trimester (between 30- and 36-week gestation), at delivery, and postpartum (2 weeks after delivery). Subjects enrolling during the second trimester also had samples collected between 20- and 26-week gestation. Subjects were stable on the ARV regimen for at least 2 weeks before PK sampling. The timing of dosing for the 3 days before and the day of the PK evaluation was the same and was the same for the PK evaluations performed during pregnancy and postpartum. Seven plasma samples were drawn at the second trimester, third trimester, and at the postpartum PK evaluation visits, starting immediately before the morning oral LPV dose and at 1, 2, 4, 6, 8, and 12 hours postdose. LPV was given as an observed dose after a standardized meal of approximately 850 kcal, with approximately 55% of calories from fat. Other information collected included the time and description of the 2 most recent meals and maternal height and weight on the day of sampling. Transplacental passage of LPV was assessed by measurement of drug concentrations in a single maternal plasma sample at the time of delivery and an umbilical cord sample after the cord was clamped.
LPV and RTV were measured by the Pediatric Clinical Pharmacology Laboratory at the University of California San Diego using a validated, reverse-phase multiplex high-performance liquid chromatography method. The lower limit of detection was 0.091 µg/mL for LPV and 0.094 µg/mL for RTV. The interassay coefficient of variation was 10.9% at the limit of detection for both drugs and ranged from 1.7% to 9% coefficient of variation for low, middle, and high controls. Overall recovery from plasma was 98% for LPV and 117.3% for RTV. The University of California San Diego laboratory has been enrolled in the ACTG quality assurance/quality control proficiency testing program since 2001, which tests samples twice a year.7
The concentration data were analyzed by direct inspection to determine predose concentration (Cpredose), maximum plasma concentration (Cmax), the corresponding time (Tmax), the minimum plasma concentration (Cmin), the corresponding time (Tmin), and the 12-hour postdose concentration (C12h). For concentrations below the assay limit of detection, a value of one half of the detection limit (0.045 µg/mL for LPV, 0.047 µg/mL for RTV) was used in summary calculations. AUCs during the dose interval (from time 0 to 12 hours postdose) for LPV and RTV were estimated using the trapezoidal rule. Oral clearance (CL/F) from plasma was calculated as dose divided by AUC. Half-life was calculated as dose divided by the terminal slope of the curve (λz), and apparent volume of distribution (Vd/F) was determined by CL/F divided by λz.
Both Vd/F and CL/F were also estimated using a 1-compartment model in the software program WinNonlin, version 5.0.1 (Pharsight Corporation, Mountain View, CA). PK parameters derived from each approach were compared to assess potential limitations of each methodology.
Target enrollment for the increased dose LPV arm of P1026s was 25 women. To prevent ongoing enrollment of subjects receiving inadequate dosing, enrollment was to be stopped early if 6 study subjects had third trimester LPV AUCs below the estimated 10th percentile for the nonpregnant historical controls (52 µg·h−1·mL−1). The statistical rationale for these early stopping criteria has been previously described.4
The comparisons of third-trimester versus postpartum lopinavir exposure were made at the within-subject level, using 90% confidence limits for the geometric mean ratio of AUC and Cmax in pregnant versus non pregnant conditions. When the true geometric mean of the ratio (the antilog of the true mean of the log ratios) of the PK exposure parameters for pregnant and nonpregnant conditions has a value of 1, it indicates equal geometric mean PK exposure parameters for the pregnant and nonpregnant conditions. If the 90% confidence intervals (CIs) are entirely outside the limits (0.8, 1.25), the PK exposure parameters for the pregnant and nonpregnant conditions are considered different. If, on the other hand, the 90% confidence limits are entirely within the limits (0.8, 1.25), the drug exposures are considered equivalent. If the 90% CI overlaps with (0.8, 1.25), these data alone do not support any conclusions. The difference in AUC antepartum and postpartum was also assessed with the Wilcoxon signed-rank test. Descriptive statistics, including geometric least squares means as a measure of location and 90% CIs as a measure of dispersion, were calculated for PK parameters of interest during each study period.
A total of 26 women were enrolled. Of these, PK sampling was completed during the second trimester in 8 women, during the third trimester in 26, and at 2 weeks postpartum in 23 between June 2003 and October 2005. The clinical characteristics of the subjects and their pregnancy outcomes are presented in Table 1. LPV and RTV were well tolerated by the subjects. Only 3 grade 3 or grade 4 toxicities were noted, 1 each of hypoglycemia, pedal edema, and elevated amylase, and none were attributed to LPV or RTV. Plasma viral load at delivery was less than 400 copies per milliliter in 24 of 25 subjects. Delivery viral load was not available in 1 woman. Twenty-four infants are uninfected; infection status is indeterminate at this time for one infant, and no HIV test results were available for one infant.
LPV and RTV PK parameters with standard adult dosing (LPV 400 mg/RTV 100 mg twice daily) during the second trimester (n = 8) and with increased dosing (LPV 533 mg/RTV 133 mg twice daily) during the third trimester (n = 26) and at 2 weeks postpartum (n = 23) are presented in Table 2. LPV concentrations increased with the increase in dose from the second to the third trimester and were highest at the postpartum visit (Fig. 1). Lags in LPV absorption were noted in 4 (50%) of 8, 8 (31%) of 26, and 9 (39%) of 23 subjects in the second trimester, third trimester, and postpartum, respectively (Fig. 2). These proportions are not significantly different.
The target LPV AUC during pregnancy was at least 52 µg·h−1·mL−1, the estimated 10th percentile AUC based on available data from nonpregnant adults.5 The 50th percentile LPV AUC in nonpregnant adults is 82.8 µg·h−1·mL−1.5 Five (63%) of the 8 subjects studied during the second trimester exceeded the 10th percentile AUC target compared with 21 (81%) of 26 third trimester subjects and 22 (96%) of 23 postpartum subjects (Fig. 3). LPV concentration 12 hours after the dose (evening trough) exceeded 1.0 µg/mL, the standard LPV trough concentration target for treatment-naive adults in therapeutic drug monitoring programs, at all times studied except for 1 woman during the second trimester.
The geometric mean third trimester/postpartum LPV AUC ratio was 0.59 (90% CI, 0.50 to 0.70) (Fig. 3). The CI for the AUC ratio fell completely outside the limits of 0.8, 1.25, showing that third trimester and postpartum AUC values were different. The geometric mean third trimester/postpartum Cmax was 0.65, and the CI for this ratio also fell outside 0.8, 1.25 (90% CI, 0.58 to 0.74), indicating that Cmax was different between these time points. The third trimester/postpartum Cmin ratio was 0.69, but the CI did not fall outside the 0.8, 1.25 bounds (90% CI, 0.35 to 1.34).Within-subject comparisons of the PK parameters AUC, CL/F, Cmin, Cmax, Cpredose, and C12h showed that postpartum LPV exposure was higher and CL/F lower than in the third trimester P ≤ 0.001 for all comparisons.
The LPV geometric mean AUC ratios of second trimester/third trimester and second trimester/postpartum were 0.7 (90% CI, 0.5 to 0.9) and 0.48 (90% CI, 0.3 to 0.7), respectively. Within-subject AUCs were significantly lower in the second trimester compared with the third trimester and postpartum (P = 0.03 and 0.02, respectively). All other PK parameters were not significantly different in the second trimester.
The 1-compartment analysis yielded similar LPV exposure parameters to the noncompartmental analysis. The 1-compartment median (range) second trimester, third trimester, and postpartum CL/F values were 6.7 L/h (3.9–13.3 L/h), 6.3 L/h (3.5–16.9 L/h), and 3.1 L/h (1.8–8.2 L/h), respectively. The corresponding Vd/F estimated values were 51 L (31–301 L), 66 L (31–270 L), and 58 L (15–285 L).
For RTV, similar to LPV, the third trimester AUC, Cmin, Cpredose, and C12h were all lower and CL/F was higher than at the postpartum visit (P ≤ 0.01 for all comparisons). The third trimester Cmax, however, was not different than the postpartum Cmax. The second trimester RTVAUC was also lower than the third trimester and postpartum AUCs (P ≤ 0.03), and other RTV PK parameters were not different in the second trimester.
Maternal plasma and umbilical cord samples were collected at delivery for 23 subjects. Two pairs were below the assay detection limit in both the maternal and umbilical cord samples. The median (range) maternal and cord blood LPV concentrations were 4.6 µg/mL (<0.091–10.1 µg/mL) and 0.89 µg/mL (<0.091–11.2 µg/mL), respectively. The median (range) cord blood/maternal sample concentration ratio was 0.23 (0.08–1.11). A single subject had cord blood concentrations greater than the maternal sample concentration (cord blood LPV = 11.2 µg/mL, maternal plasma LPV = 10.1 µg/mL; ratio = 1.11); all other subjects had less than half of the maternal LPV concentration detected in the cord blood.
In our previous study, standard dosing of LPV/RTV (400/100 mg using 3 of the 133/33 mg capsules twice a day) during the third trimester resulted in LPV plasma concentrations and AUCs that were approximately 50% lower than those seen in nonpregnant adults. Use of these standard doses at 6 weeks postpartum resulted in LPV plasma exposure equivalent to that seen in nonpregnant adults. Trough concentrations during the third trimester with standard dosing were below 1000 ng/mL, the usual standard used in therapeutic drug monitoring programs, in 2 (12%) of 17 women.4 Two subsequent studies confirm these findings, reporting trough LPV concentrations below 1.0 µg/mL in 6%–15% of third trimester pregnant women receiving standard dosing with LPV/RTV.8–10
In the current study, we studied LPV PK after an increased dose of 4 capsules during the third trimester and at 2 weeks postpartum, with the goal of achieving LPV drug exposure in plasma during pregnancy equivalent to that seen in nonpregnant adults. We achieved that goal, as our subjects had a median third trimester AUC of 87.5 µg·h−1·mL−1, nearly equal to the 50th percentile LPVAUC in nonpregnant historical controls of 82.8 µg·h−1·mL−1.5,11 None of the third trimester subjects on this higher dose had an LPVAUC more than twice that of the 50th percentile of the historical controls, and only a few had an LPVAUC below the target of the 10th percentile AUC in nonpregnant adults. We expanded our investigations in the current study with optional sampling during the second trimester of pregnancy. Although we studied only 8 subjects during the second trimester, these limited data suggest that LPV exposure is reduced during the second trimester as well. Median second trimester LPV AUC was 57.3 µg·h−1·mL−1, and 3 of the 8 second trimester subjects had an AUC below 52 µg·h−1·mL−1, the 10th percentile in nonpregnant adults.
In our previous study, we had documented that LPV plasma exposure had normalized with standard dosing at 6 weeks postpartum. In the current study, we sampled postpartum subjects at 2 weeks after delivery while still receiving the increased dose. Median LPVAUC at 2 weeks postpartum was nearly double that seen during the third trimester, suggesting that by 2 weeks postpartum, the pregnancy-related changes in LPV disposition that result in decreased plasma concentrations have resolved. LPV PK with standard dosing in the first days after delivery is under investigation in a separate trial, PACTG 1032, and these data should be available soon.
LPV is highly bound (98%–99%) to plasma proteins, including albumin and alpha-1-acid glycoprotein (AAG), with its affinity to AAG higher than its affinity to albumin.11 As with all highly bound drugs, small changes in protein binding may have a large effect on the concentration of free (unbound) drug, which is the pharmacologically active moiety. Protein binding may be reduced during pregnancy, due to dilutional decreases in plasma protein concentrations and competitive inhibition from corticosteroid hormones.12,13We have recently reported data describing LPV protein binding during pregnancy and postpartum using samples from subjects enrolling in this study and our previous study.14 LPV protein binding was reduced during pregnancy compared with postpartum, resulting in a 17% increase in the free fraction of LPV during the third trimester. The reduction in LPV protein binding correlated with lower AAG concentrations observed in the third trimester. A reduction in protein binding of this magnitude will only compensate for a portion of the decrease in LPV exposure associated with pregnancy.
The clinical significance of the decreased LPV concentrations with standard dosing during pregnancy is uncertain. Although definitive correlations between LPV plasma concentrations and virologic response have not been defined, the risk of virologic breakthrough in the face of low protease inhibitor trough concentrations has been raised in other contexts, especially for treatment-experienced individuals.11,15 In our previous study, 16 of 17 pregnant women treated with standard LPV/RTV dosing had viral loads below 400 copies per milliliter at delivery, although one of the subjects fully suppressed at delivery experienced a virologic breakthrough during the third trimester that required a modification in her ARV regimen before full suppression was achieved again. In 2 other cohorts of HIV-infected pregnant women treated with standard LPV/RTV dosing, 12% and 19% were not fully suppressed at delivery.8,10
Until more is known about the relationship between LPV plasma concentrations and virologic response, a reasonable goal of LPV therapy during pregnancy is to achieve plasma exposure in pregnant women equivalent to that seen in nonpregnant adults. This goal is likely to be especially important in ARV-experienced subjects, where the development of resistance has been associated with lower LPV concentrations.16–18 The standard dose of 3 capsules twice a day during the second or third trimester did not meet this goal, but the increased dose of 4 capsules twice a day (533 mg LPV/133 mg RTV per dose) during the third trimester did. These data suggest that the higher LPV/RTV dose should be used in third trimester pregnant women and that it should be considered in second trimester pregnant women, especially those who are protease inhibitor experienced. As this study was performed in US women, extrapolation to other populations may be confounded by differences in size, genetics, diet, and concomitant illnesses, among other factors. Therapeutic drug monitoring may be useful in ensuring adequate LPV exposure during pregnancy, especially in women outside the United States. Our postpartum results suggest that by 2 weeks postpartum, the increased dose is no longer needed. The capsule formulation has now been replaced in the United States by a newer tablet formulation with improved bioavailability characteristics. Each tablet contains 200 mg LPV and 50 mg RTV, and standard adult dosing is 2 tablets twice a day or 4 tablets once a day. A study of the PK of this new tablet formulation during pregnancy and postpartum is under way.
We thank the subjects who enrolled in this trial. Thanks to Diana Estrada-Stolpe, PharmD, for her contributions to the PK analysis. In addition to the authors, members of the PACTG 1026s Protocol Team include the following: Carol Elgie, BS, Diane T. Holland, MPhil, Beth Sheeran, MS, RD, Joanne Schiffhauer, BS, Maureen Shannon, MS, CNM, James D. Connor, MD, Francesca Aweeka, PharmD, Bradley W. Kosel, PharmD, and Kathleen A. Medvik, BS, MT; The Columbia Presbyterian Medical Center: Seydi Vazquez, RN, MSN, and Diane Tose, RN; Baystate Medical Center, Springfield, MA: Barbara W. Stechenberg, MD, and Eileen Theroux, RN, BSN; Boston Medical Center, Boston, MA: Meg Sullivan, MD, and Laureen Kay, RN; Brigham and Women's Hospital, Boston, MA: Ruth Tuomala, MD, and Arlene Buck, RN; Bronx-Lebanon Hospital, New York, NY: Mavis Dummitt, RN, Caroline Nubel, Stefan Hagmann, MD, and Murli Purswani, MD; Children's Hospital and Regional Medical Center, Seattle, WA: Jane Hitti, MD, MPH, Ann Melvin, MD, MPH, Michele Acker, PNP, and Deb Goldman, ARNP, MPH; University of Southern California, Los Angeles, CA: Ana Melendrez, RN, Françoise Kramer, MD, LaShonda Spencer, MD, and Yvonne Rodriguez, LVN; SUNY Health Science Center, Stony Brook, NY: Sharon Nachman, MD, Denise Ferraro, RN, Jennifer Griffin, NP, and Paul Ogburn, MD; St. Jude's Children's Research Hospital, Memphis, TN: Edwin Thorpe, Jr, MD, Nina Sublette, RN, MSN, FNP, Katherine Knapp, MD, and Jill Utech, RN, MSN, CCRC; Children's Hospital, University of Colorado, Denver, CO: Adriana Weinberg, MD, Jill Davies, MD, Carol Salbenblatt, MSN, and Suzanne Paul, FNP; University of California at Los Angeles Medical Center, Los Angeles, CA: Margaret Keller, MD, Marie Beall, MD, Spring Wettgen, RN, PNP, and Nicole Falgout, RN; University of California, San Diego Mother Child and Adolescent HIV Program: Andrew D. Hull, MD, Mary Caffery, RN, MSN, Linda Proctor, RN, MSN, CNM, and Stephen A. Spector, MD; University of Miami, Miami, FL: Amanda Cotter, MD, Gwendolyn B. Scott, MD, Charles Mitchell, MD, and Liset Taybo, MD; University of Massachusetts Medical Center, Worcester, MA: Katherine Luzuriaga, MD, and Sharon Cormier, RN; and Yale University School of Medicine, New Haven, CT: Warren A. Andiman, MD, and B. Joyce Simpson, RN, MPH.
Supported in part by the Pediatric AIDS Clinical Trials Group of the National Institute of Allergy and Infectious Diseases (Grants U01 AI04189, U01 AI41089, UO1 AI27560-18, and U01 AI32907), the General Clinical Research Center Units funded by the National Center for Research Resources (Grants MO1 RR00069, M01 RR00533, and M01 RR01271), and by the Pediatric/Perinatal HIV Clinical Trials Network of the National Institute of Child Health and Human Development (Contract N01-HD-3-3365).
Presented in part at the 13th Conference on Retroviruses and Opportunistic Infections, February 6, 2006, Denver, CO. Abstract number 710.
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


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Kyosho Servo Saver Set
This item is discontinued and no longer available for purchase. You may want to search our site for a similar item.
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Discontinued Online
This is a replacement Kyosho Servo Saver Set. This set includes assembled with spring and collar. This package includes the servo savor, two posts and two bushings. For optimal performance, bearing use is recommended.
This product was added to our catalog on February 3, 2009.


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November 28th, 2010 by sabrina
Amaltheia (pronounced a-mal-THEE-uh) is a Greek Nymph, who, according to some sources, fed the infant Zeus with the milk of a goat. Other sources say that she actually was the goat. As a nymph, she was the wife of King Melisseus of Crete, and mother of the nymphs Adrasteia and Ida, who helped her to nurse Zeus. Aside from feeding Zeus, Amaltheia also suspended him in a cradle from the branch of a tree, so that he could not be found in heaven, on earth, or in the sea. When her goat broke off one of its horns, she filled it with herbs and fruit and gave it to the baby—the first horn of plenty or cornucopia. Zeus later placed the goat and its horn among the stars, as the constellations Capra and Capricornus. Amaltheia's name, which means either "tender goddess" or "she who nourishes," is also seen as Amalthea or Amalthia.
This entry was posted on Sunday, November 28th, 2010 at 9:11 am and is filed under Greek. You can follow any responses to this entry through the RSS 2.0 feed. Both comments and pings are currently closed.


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Klopp explains his team selection against Crystal Palace
Liverpool manager Jurgen Klopp has revealed the reason that Mohamed Salah was...
Alex McLeish, Zamalek's new head coach, commented aggressively on Zamalek's 3-1 loss against 10 man El-Entag El-Harby.
McLeish spoke to journalists after the loss against El-Entag El-Harby, mentioning his objectives for the club and stating Zamalek's weak points. He started off elaborating on his intentions to change the players' mentality.
After hitting the table aggressively the Scot mentioned "I must change the players mentality." He added; "Emmanuel Mayuka and Mahmoud Kahraba missed many chances and I don't know the reason."
McLeish preferred to start with the last formation that lead Zamalek to win in the Egyptian Premier League, with small changes such as the inclusion of Tarek Hamed.
"I have no idea on why we missed so many chances, but I'll work on it and on improving the defensive line. I'll do my best to improve the team." McLeish stated.
"I am very surprised at the defensive line performance. I knew that Ahmed El-Shennawy is Zamalek's goalkeeper and I'll have to talk to the players about the reasons behind our loss in our next training." the manager added aggressively.
McLeish said that he didn't promise that Zamalek were going to win the League but he'll work on winning it. With the loss Zamalek stay 6 points away from league leaders and rich rivals Al Ahly, currently sitting 38 points after playing 20 matches.


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Several refugees in Düsseldorf's set fire because they were not given a wake-up call to celebrate Ramadan. There has been reported violence in various refugee camps around the world. In Denmark they attacked police for trying to remove a young girl to prevent her for being continually raped. They have set fires and began riots for not being happy with their accommodations. Most recently they set fire to the facility where they were being housed because they were not given a wake up call. The refugees who witnessed the fire proudly recorded it on their phones.
There were initially two arrests of migrants that were found at the scene boasting about setting the fire, but this number later rose to six. The men arrested are reported to have been citizens of Morocco, Algeria, Syria and Iraq.
Refugees are commonly given jobs and some are employed as security. This has caused conflict and has led to widespread abuse and violence.


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Okay firstly, the only draw back for this place is that there is NO sign board on the main road (Ngong Road). L'Arena is located on your right hand side on Ngong road if you are driving from Nakumatt Junction sides and the left side if you are coming from Karen. They are located in a place called Shalom House.
I was slightly disappointed with their bitings (bread with cold tomatoes - didn't manage to finish one) Hope they can work on this.
Now, onto the fun part- the pizzas - one word to cover it - AwesomeLicioussss :) The pizzas are made in the brick oven powered by wood fire. So when you do take a bite from your piping hot pizza, you will be able to taste Everything (the base, The paste and the toppings).
My friends have tried their pastas and say its good too but I am all about Pizza at L"arena and have never gone wrong.
Thanks to Katra and her team for taking good care of us.
For all the cheese lovers like me, ask them to put in a good portion of cheese and you will love the strands pulling and melting in your mouth.
My favorite pizza is the margarita with a dash of green chillies. Fire it up!!
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Leave No Book Behind
193 votes
625 visits
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SAO PAULO, July 22 (Reuters) - A Brazilian judge overseeing the bankruptcy protection process of phone carrier Oi SA on Friday named auditing and advisory firm PricewaterhouseCoopers as the company's in-court administrator.
Judge Fernando Cesar Ferreira Viana, who is based in Rio de Janeiro, also tapped law firm Arnoldo Wald to work alongside PricewaterhouseCoopers on the in-court reorganization of Oi, according to a statement published on the court's website.
Reuters reported earlier this month that Alvarez & Marsal Holdings LLC, PricewaterhouseCoopers and Deloitte & Touche LLP applied for the mandate to oversee Oi's bankruptcy protection.
An in-court administrator usually looks after the interests of creditors in the company under bankruptcy protection during the process.
Industry sources have said PricewaterhouseCoopers, a household name in global insolvency cases, has not advised on any of Brazil's biggest bankruptcy protection cases since the firm began working on the segment two years ago.
Oi shareholders earlier on Friday reiterated their support for efforts by the management of Brazil's largest fixed-line phone carrier to pursue an in-court reorganization, which would be the country's biggest ever.
In June, Oi filed a request before the Rio de Janeiro court to reorganize 65 billion reais ($20 billion) of bank, bond and operational liabilities in court. ($1 = 3.2559 Brazilian reais) (Reporting by Ana Mano; editing by Guillermo Parra-Bernal, G Crosse)


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We've migrated material from this wiki to the zephyrproject.org documentation site or to the new Zephyr GitHub wiki
From Zephyr Project Wiki
Does Zephyr have a shell?
Nope, Zephyr has no default shell, prompt or default UI -- Zephyr is deeply embedded.
There is, however, an infrastructure for creating your own shell commands. See, in the Zephyr source code, samples/shell.
How do I contribute to the wiki?
- Signup process.
- Linking pages to navigation (Orphan pages).
How do I build the documentation?
- Ensure you have the tools (https://www.zephyrproject.org/doc/README.html)
- clone the code and run make -C PATH/TO/CODE/doc
How do I deprecate a function?
- tag it __deprecated
- You might have to do some workarounds with the documentation (https://wiki.zephyrproject.org/view/Function_Documentation#Workarounds)


text: This is a section of the website that will be ongoing, which means that I'll be updating characters and adding them as I have the time. So if there's a character in the books that you'd love to see in the CG, and s/he is not already listed, you may request that character in the comments. Keep in mind, that does not mean I'll include them. Some characters prefer to remain a mystery. 😉


text: Here's something I haven't seen addressed before. If I am looking up an address on my phone (2.1 leak v3), there is no way to see the full address. Even in edit mode, I would have to maneuver just to see the whole address. Am I missing something, or is there some kind of a fix?? I noticed the same issue with 1.5 and hoped that the 2.1 would fix this.


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Counterparty Risk Subject To ATE
Rating trigger ATE (Additional Termination Event) is a counterparty risk mitigant that allows banks to terminate and close out bilateral derivative contracts if the credit rating of the counterparty falls below the trigger level. Since credit default is often preceded by rating downgrades, ATE clause effectively reduces the counterparty credit risk by early termination of exposure. However, there is still the risk that counterparty may default without going through severe downgrade. This article presents a practical model for valuating CVA in the presence of ATE.
If you experience problems downloading a file, check if you have the proper application to view it first. In case of further problems read the IDEAS help page. Note that these files are not on the IDEAS site. Please be patient as the files may be large.
|Date of creation:
|Dec 2010
|Contact details of provider:
| Postal: Ludwigstraße 33, D-80539 Munich, Germany
Phone: +49-(0)89-2180-2459
Fax: +49-(0)89-2180-992459
Web page: https://mpra.ub.uni-muenchen.de
More information through EDIRC
References listed on IDEAS
Please report citation or reference errors to , or , if you are the registered author of the cited work, log in to your RePEc Author Service profile, click on "citations" and make appropriate adjustments.:
- Damiano Brigo & Massimo Morini, 2010. "Dangers of Bilateral Counterparty Risk: the fundamental impact of closeout conventions," Papers 1011.3355, arXiv.org.
- Robert A. Jarrow & David Lando & Stuart M. Turnbull, 2008.
"A Markov Model for the Term Structure of Credit Risk Spreads,"
World Scientific Book Chapters,in: Financial Derivatives Pricing Selected Works of Robert Jarrow, chapter 18, pages 411-453
World Scientific Publishing Co. Pte. Ltd..
- Jarrow, Robert A & Lando, David & Turnbull, Stuart M, 1997. "A Markov Model for the Term Structure of Credit Risk Spreads," Review of Financial Studies, Society for Financial Studies, vol. 10(2), pages 481-523.
- Robert B. Israel & Jeffrey S. Rosenthal & Jason Z. Wei, 2001. "Finding Generators for Markov Chains via Empirical Transition Matrices, with Applications to Credit Ratings," Mathematical Finance, Wiley Blackwell, vol. 11(2), pages 245-265.
- Damiano Brigo & Kyriakos Chourdakis, 2009. "Counterparty Risk For Credit Default Swaps: Impact Of Spread Volatility And Default Correlation," International Journal of Theoretical and Applied Finance (IJTAF), World Scientific Publishing Co. Pte. Ltd., vol. 12(07), pages 1007-1026. Full references (including those not matched with items on IDEAS)
This item is not listed on Wikipedia, on a reading list or among the top items on IDEAS.
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Custom Search
Canada Hamilton Real-Estate Page 4
Hamilton Real Estate & Homes for Sale
Hamilton Ontario Real Estate, Expect More From Les
Royal LePage Hamilton real estate agent, Les Myers, is a positive, professional and experienced Realtor who offers buyers and sellers automatic alerts to find new MLS listings of homes, town houses and condos for sale in Hamilton, free market evaluations. Service incl. Stoney Creek, Ancaster, Dundas, Grimsby cottages, investment properties and residential homes for sale. Visit website for tips, resources and Royal LePage TV.
Ancaster, Dundas Real Estate Ontario
This site provides real estate listings, real estate homes for sale, tips on buying a home, tips on selling a home, mortgage calculator, real estate information, listings for sale, properties for sale, mls real estate, home evaluation services, real estate evaluations and home improvement tips, Hamilton, Burlington, Ancaster, Dundas.
The Mazza Team - Change your home, Change your life
2009 will mark 22 years of selling Real Estate for Martin. Martin Mazza has consistently proven himself as a Leader in Sales year over year. Martin's strong work ethic, in depth knowledge of the market, professional dedicated manner combined with his years of experience makes him an excellent choice for both Sellers and Buyers. He has provided service to all of our Real Estate Board communities, from Grimsby & Stoney Creek through Hamilton & Burlington and all the surrounding areas!
Paul Wheeler, Sutton Group Innovative Realty Inc., Brokerage
Multi Platinum award winning Sutton Group real estate agent with over 25 years of helping residential home buyers, house sellers in Hamilton Ontario. Find Hamilton real estate services, MLS listings alerts, houses for sale, property evaluations. Paul's professional yet fun loving approach as a Sutton Group Hamilton realtor leaves you with a positive and satisfying encounter. Call Paul for your Hamilton real estate requirements.
Marianne Nalepa - Royal LePage State Realty, Brokerage
Buyers start an online search for Hamilton homes, townhouses or condos for sale and get new listings of MLS Hamilton properties delivered to your inbox. Sellers can find out how much your house is worth with a free market evaluation. More Hamilton Ontario real estate information, reports, videos and ealty services provided by Royal LePage Hamilton real estate agent Marianne Nalepa. Contact Marianne for all your Hamilton rel estate needs.
Walsh and Volk Remax Real Estate
Service is taking the time to make sure the details are looked after. Service is the constant commitment to increased knowledge that is unseen. Service is the 1000′s of hours negotiating that are distilled to a sharp point, that can be executed when you need it most! Service is doing the right thing for you, the client. This is the kind of service that keeps client coming back to us!
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Canada Hamilton Real-Estate Page 4


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Have questions?
Call us toll free.
March 14:
Gold's post-Fed slide continues
Source: American Gold Exchange
-- Gold lost 3% and silver 4.2% today as yesterday's Fed-driven slide continued. Prices for Treasury bonds were also hit hard as yields rose to their highest level in four months and the dollar strengthened, reaching an 11-month high against the yen. It was gold's lowest close in eight weeks. Platinum and palladium both fell 1.6%.
At the close: April gold lost $51.30 to $1,642.90; May silver dropped $1.40 to $32.18; April platinum slid $26.50 to $1,675.30; and June palladium fell $11.15 to $697.70 an ounce
The main driver behind gold's slide is continuing fallout from yesterday's FOMC statement signaling a slightly improved outlook for growth and offering no hints of pursuing another round of quantitative easing in the near future. The Fed actually said nothing either way about additional easing, but the silence was seen as reducing the likelihood of QE3. Speculative players like hedge funds, which had built up long wagers in anticipation of more easing, headed for the exits. Still, the Fed said positively that its current asset-purchasing programs will continue unabated, as will its policy of near-zero interest rates until late 2014, both of which are supportive of higher gold prices because they increase inflation risk.
Ironically, as Bloomberg reported today, many economists think Bernanke's statement actually keeps the door open for additional easing. The way the statement was crafted was to keep their options open, said Stephen Stanley, chief economist at Pierpont Securities LLC. Mohamed El-Erian, chairman of investment giant Pimco, still sees more easing on the way: Our own view is that QE3 will probably materialize down the road simply because the endogenous engines of growth, while they are picking up, are not strong enough yet given all the headwinds faced that face the U.S. economy." And at the annual Bloomberg Link Precious Metals Conference in New York yesterday, the consensus among the economists and fund managers surveyed was that "gold is poised for a 21% gain in 2012" because of record amounts of hoarding by individuals and the expansion of reserves by central banks for the first time in a generation. QE3 wasn't mentioned as a key to higher prices.
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Wenger admits Bothroyd regrets
Arsenal boss Arsene Wenger admits he regrets losing Jay Bothroyd as a youngster for disciplinary reasons.
Last Updated: 14/11/10 7:00pm
Arsenal manager Arsene Wenger has admitted he regrets losing Jay Bothroyd as a teenager.
The Cardiff striker, who has gone on to win an England call-up, was sold by Arsenal for disciplinary reasons ten years ago after throwing a shirt following his substitution in an Under-19 match.
Head of youth development Liam Brady told Bothroyd he was no longer wanted at the Gunners, with the striker moving on to Coventry and also having spells at Perugia, Blackburn, Wolves, Charlton and Stoke before arriving at present club Cardiff.
The 28-year-old has been in great form this term, netting 15 times to help the Bluebirds to the top of the Championship and earning a first ever call up to Fabio Capello's England squad for the friendly against France on Wednesday.
Wenger, who congratulated the striker on his achievement, said: "He is one of my regrets, he left very early.
"But I have said many times it is important a guy has a good career, even if he goes somewhere else.
"It is better than to play in the reserves.
"He went down but has come back up again and we are all very proud of him at Arsenal."
Wenger did not stand in the way of the decision to axe Bothroyd, but believes he has now matured into a fine player.
He added: "Sometimes it is only later they realise they not only have to have talent, but need to work as well.
"Sometimes to go down to the Championship, there is no better education.
"It is true, he had a little outcome that you can have when you are 16 or 17 but he is a good guy, and he is classy; left-footed, strong body, fantastic technique.
"The incident didn't happen in the first-team group, it happened in the youth team.
"Liam Brady is responsible for that. They made the decision and I didn't stand in the way because it was a disciplinary matter."


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Malcolm Whyman has worked and lived in the Nottingham area for the majority of his life. He was a well known face on the Nottingham folk/session scene for many years, personally organising a Monday night sing and drink for a decade. He began writing his biography in 2008, which is now available for free download. He is currently writing two other fictional works, and is near completing a series of folk poems.
Review by:
Howard Gagnon
on March 24, 2013 :
very good read
(review of free book)
Review by:
catherine Holliday
on Sep. 30, 2011 :
(no rating)
What a wonderful read. I was captured from the first page and read the whole book in two sittings seperated only by the need to have food.If you only read one book this year please make it this one. It's funny, pithy and made me laugh out loud and cry. I want to meet this man!
(review of free book)


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Need a cheap blood test in Cleveland Heights, OH? Simply order online and get a cheap blood test at a lab near you (Find More Locations):
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What is JotForm?
JotForm is a free online form builder which helps you create online forms without writing a single line of code. No sign-up required.
At JotForm, we want to make sure that you're getting the online form builder help that you need. Our friendly customer support team is available 24/7.
We believe that if one user has a question, there could be more users who may have the same question. This is why many of our support forum threads are public and available to be searched and viewed. If you'd like help immediately, feel free to search for a similar question, or submit your question or concern.
Hi- I am trying to create a link of the URL address in an email where its a click function titled "Click on Me." Can you please help?Asked by jwu702 on May 14, 2016 at 12:27 PM
I'm not sure if I completely understood what you meant by creating a "link of the URL address in an email".
Are you looking to create a static URL - which will be the same for all your users - and include it in your email notifications or autoresponders?
If so, you need to first create an email notification or an autoresponder:
When setting up the email notification/autoresponder, you can create a link by using the chain-shaped toolbar icon of the email:
It will create a link to that URL:
If you were looking for something else, please described what you were looking to achieve in a little more detail, and we'll be happy to help.


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There is broad consensus on the need to shift to a new paradigm of lifestyles and economic development, given the un-sustainability of current patterns. Given this, research on consumer behavior is to play a crucial role in shedding light on the motives underpinning the adoption of responsible…
Hardback – 2017-10-26
Routledge-SCORAI Studies in Sustainable Consumption
With fifteen essays by scholars and professionals, from fields such as policy and law, Health and Well-being for Interior Architecture asks readers to consider climate, geography, and culture alongside human biology, psychology, and sociology. Since designers play such a pivotal role in human…
Paperback – 2017-06-20
The power of capital is the power to target our attention, mould market-ready identities, and reduce the public realm to an endless series of choices. This has far-reaching implications for our psychological, physical and spiritual well-being, and ultimately for our global ecology. In this consumer…
Hardback – 2017-06-08
Routledge Studies in Sustainability
Studies confirm that the physical environment influences health outcomes, emotional state, preference, satisfaction and orientation, but very little research has focused on mental and behavioural health settings. This book summarizes design principles and design research for individuals who are…
Paperback – 2017-05-17
Climate change and ecological instability have the potential to disrupt human societies and their futures. Cultural, social and ethical life in all societies is directed towards a future that can never be observed, and never be directly acted upon, and yet is always interacting with us. Thinking…
Paperback – 2017-04-09
Routledge Explorations in Environmental Studies
Originally published in 1987, this title intended to historically reveal, through tracing Gibson's development, the substance of his views and how they bore upon general philosophical issues in theories of knowledge, and to investigate in detail the historical context of Gibson's theoretical…
Hardback – 2017-03-13
Psychology Library Editions: Perception
Making Places for People explores twelve social questions in environmental design. Authors Christie Johnson Coffin and Jenny Young bring perspectives from practice and teaching to challenge assumptions about how places meet human needs. The book reveals deeper complexities in addressing basic…
Paperback – 2017-01-19
In this groundbreaking book, Renee Lertzman applies psychoanalytic theory and psychosocial research to the issue of public engagement and public apathy in response to chronic ecological threats. By highlighting unconscious and affective dimensions of contemporary ecological issues, Lertzman…
Paperback – 2016-12-02
Psychoanalytic Explorations
Risk analysis is not a narrowly defined set of applications. Rather, it is widely used to assess and manage a plethora of hazards that threaten dire implications. However, too few people actually understand what risk analysis can help us accomplish and, even among experts, knowledge is often…
Paperback – 2016-09-19
Earthscan Risk in Society
As prosperity levels rise, so too does the number of products and services being consumed. For policy makers in waste management facing a growing challenge, it is vital to understand the complex relationship between waste prevention policies and individual behaviour regarding waste generation. This…
Paperback – 2016-09-09
Routledge Studies in Waste Management and Policy
Originally published in 1974, this volume is primarily devoted to what is known about human infancy from an ethological, evolutionary viewpoint. Included are discussions of pan-specific traits, presumably shared by all infants; individual genetic variations on these behaviours (as judged by…
Hardback – 2016-06-27
Psychology Library Editions: Cognitive Science
The User Perspective on Twenty-First Century Art Museums explains contemporary museums from the whole gamut of user experiences, whether users are preserving art, creating an exhibit, visiting, or part of institutions that use the architecture for branding. Fourteen museums from the United States,…
Paperback – 2016-06-22


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Lysergic Acid Diethylamide (LSD)
LSD is a hallucinogenic drug.
Acid, Beast, Blackbird, Alice, LSD. Whatever street name you want to call it, LSD is a hallucinogenic drug. That means that once you take it, it changes the way you hear, smell, feel, taste and see the world around you. Thirty to ninety minutes after taking the drug, either in pill or liquid form, or by placing small sheets of absorbent paper infused with the drug on your tongue, you would start to feel the effects LSD has to offer.
Physically, you would lose your appetite and your pupils would get smaller. Your body would get hotter or colder, causing you to get the chills or sweat. Your mouth would get dry and you might even experience tremors, which is when you shake uncontrollably. But the physical effects are not the ones that LSD is known for.
LSD causes your cerebral cortex, the part of your brain that controls your mood and views of things, to make things up, which creates delusions that aren't really there. For example, you would see visual hallucinations that would feel real, you would have no sense of time or who you are, and you would have terrifying thoughts and feelings of paranoia, panic attacks and flashbacks.
most popular psychedelic drug
Despite the effects, it is still Canada's most popular psychedelic drug. As of 2008, about three million people in the USA between the ages of 12 and 25 have admitted to using LSD. It's a contained substance in Canada, which means it's not illegal as long as you have medical authorization to use it. Fatal overdoses of the drug are rare but possible, but the real thing to be afraid of is the complications of taking the drug.
When you take LSD, it becomes hard to tell what is reality and what is hallucinations. This could cause you to do things, based on the hallucinations, that could harm you, or the people around you. An example of this is having the feeling that bugs are crawling under your skin, and so many people scratch and cut at their skin during their trips, leaving scabs and most often scars when the bad trip is over.
The history of lsd
This drug was first created in Switzerland in the 1930's. A chemist named Albert Hoffmann was researching lysergic acid derivatives, in other words things that could be made from lysergic acid, and accidentally created LSD. It wasn't until the 1940's however, that Hoffmann realized what he had created. He decided to re-evaluate the drug and when he took it out to examine it again, he accidentally dosed himself with a small quantity of it. His experience was written down and described:
"... affected by a remarkable restlessness, combined with a slight dizziness. At home I lay down and sank into a not unpleasant intoxicated[-]like condition, characterized by an extremely stimulated imagination. In a dreamlike state, with eyes closed (I found the daylight to be unpleasantly glaring), I perceived an uninterrupted stream of fantastic pictures, extraordinary shapes with intense, kaleidoscopic play of colors. After some two hours this condition faded away."
How it's made
LSD is made by chemists in laboratories all around Canada, since it is considered a contained drug and is therefore legal. LSD's main ingredient is lysergic acid, which is a fungus that grows on rye's and other grains. The laboratories produce a crystal using lysergic acid and other important ingredients that are not disclosed, and then the crystal is formed into either pills, liquids or applied onto absorbent papers.


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A beautiful four bedroom stone cottage with off road parking for up to three cars. The original 1800's cottage was sympathetically extended in the 1960s to product this spacious family home. There is an attractive front garden and a lovely walled garden to the rear with ornamental pond and a large shed. Downstairs has two equal size reception rooms either side of the central staircase, both are dual aspect with open fires. There is a newly fitted shaker style kitchen diner, a large utility room and a separate downstairs toilet. Upstairs there are three good sized double bedrooms, one with an ensuite shower room, and a smaller bedroom that could also be used as an office. The master bedroom is large with dual aspect window and views to the front and rear. The large family bathroom has a bath as well as a double walk in shower. The house benefits from gas central heating and has been tastefully decorated throughout.
Book a viewing online in minutes. Just click below to choose the days and times
you're able to view the property and you'll receive an email and SMS as soon as the owner confirms one of your options.
Get started by requesting your free valuation from today. With our fees at just £795, you can save thousands selling with the UK's best rated online estate agent.Get Your Free Valuation


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My site name is www.AAABB.com my alexa ranking is about 500000. but on the google search, when search the key word " AAA BB" my site always in about the 10th page. From my experienced before, when search the name's key word, my site should appear on about the 1th - 3th page.
Another site www.AAABB.co.uk which has the same name with my site, when I search the key word on google, it always appear on the first page. but its alexa ranking is just about 2000000.
Can anybody tell me what should I do to improve my ranking ? Thank you very much!!
Having keywords in the domain
Having keywords in the domain doesn't guarantee rankings.
It's difficult to give recommendations without any details to go on.
Try comparing your website with your competitors on some basic SEO metrics such as backlink profile and domain citations.
Can't get the site to load
Are you having larger issues with your site?
First, I couldn't get your site to load.
Second, are your homepage and other pages currently getting indexed, or are you blocking them? When I search "site:aaabb.com", I don't see your homepage and only see 9 other pages, none of which load.
Also, as John said above, it's typically difficult to give recs without more context, but his ideas are definitely good to get started.


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"If you can hear my voice, you can break…" Those words, spoken by beloved race announcer Kurt Steiner (1921−1993), encouraged countless race finishers to run their hearts out. Steiner was a founding member of NYRR and a competitive runner and race walker.
Born in Austria, Steiner was a member of the French Foreign Legion who escaped from enemy captors. Yankees Hall of Fame pitcher Whitey Ford was one of his soldiers in the U.S. Army. Steiner worked tirelessly behind the scenes to help stage the first five-borough New York City Marathon and assisted NYRR with race scoring, race applications, and media activities.
Please note: NYRR cross country races do not count toward the 9+1 program.
Event hashtag: #KurtSteinerXC—use it in your tweets, Instagrams, and Facebook posts!
Registration for Cross Country Races
Each of NYRR's cross country races allows for 400 runners to register online. When a cross country race reaches its online capacity, this will be noted on the race page. Additional runners will be able to sign up at the event.
Start on "The Flats," a wide field bordering Broadway, and head south. Turn left/east to pass the Van Cortlandt Mansion along the southern edge of The Flats, then left/north again to enter the woods at the Cow Path entrance. Ascend the trail as you continue north.
As the trail parallels the Henry Hudson Parkway, make the right turn toward the Back Hills. Make this complete loop, then head back toward The Flats. The trail is mostly downhill and flat. Exit the woods with about three-quarters of a mile to go and continue to the finish along Broadway beyond the Tortoise and Hare statue.
|April 26–
May 9
|May 10–
Sept. 17
|NYRR Member
|NYRR Specialty Member*
|NYRR Member Plus
|NYRR Miler/NYRR 5K Member
|NYRR 10K Member
|NYRR Friend (non-members)
|NYRR Friend–Junior
Numbers (which include your timing tag) and souvenirs may be picked up at the NYRR RUNCENTER at 320 West 57th Street (between Eighth and Ninth avenues) on the following dates:
Show the QR code from your race confirmation email or your My NYRR account to pick up your race materials. Please pick up during the week to avoid crowds on race day. Race-day lines may impact your ability to get to the start on time.
On race day, pickup will be at Race-Day Central in Van Cortlandt Park, near the Tortoise and Hare statue at Broadway and 248th Street, from 10:00 to 11:00 a.m.
Bag check, also located at Race-Day central, will be open from 10:00 a.m. to 12:45 p.m. If you wish to check a bag, please allow additional time for bag check and security.
Awards will be available to the top-three men and women overall, as well as in age and gender groups as explained in this article. A list of all award winners will be posted in the results for each race. Awards will be available after the race and distributed on-site.
Follow The MTA's Weekender schedule to plan your race-day transportation.
All race information is subject to change.
Sunday, September 17, 2017 11:30am
Van Cortlandt Park, The Bronx
Both Men and Women
Near Capacity
Are you interested in volunteering for this race? View the open opportunities at the Volunteer site.Sign Up to Volunteer
Check out our help center for information about our events.