text:
|Home | About | Journals | Submit | Contact Us | Français
In recent years, evidence has mounted in support of the importance of protein kinase CK2 (previously called casein kinase 2 or II) (EC 126.96.36.199) in diverse biological processes, and in particular in regard to its role in cell growth and proliferation in normal and disease states. In particular, emerging data have underscored a novel function of CK2 as a potent suppressor of apoptosis. Thus, it now appears that CK2 has a dual role in cell function, namely its involvement in growth and proliferation as well as in suppression of apoptosis. The latter function of CK2 is of particular significance with respect to its role in neoplasia since CK2 has been found to be consistently elevated in cancer cells which are known to demonstrate remarkable resistance to death. In this review, we have focused on the pertinent observations that implicate CK2 to have a global role as a suppressor of apoptosis and its relevance to the cancer phenotype.
CK2 (official acronym for the former name casein kinase 2 or II) (EC 18.104.22.168) is a ubiquitous protein serine/threonine kinase that is among the most highly conserved proteins in nature. A unique property of this kinase is that it can utilize both ATP and GTP as substrates. Its heterotetrameric structure consists of two catalytic subunits (42 kDa α and 38 kDa α′) and two regulatory subunits (28 kDa β) existing as α2β2, or αα′β2, or α′2β2 configurations. The two catalytic subunits are linked through the β subunits (Graham et al., 2000). The β subunits in turn may form a linkage with the nuclear matrix (Zhang et al., 1998) which is a key locus for CK2 signaling in the nucleus (Ahmed, 1999). The growth related functions of CK2 accord with CK2-mediated phosphorylation of a rather large number of substrates in the cell, many of which are nuclear-associated and are involved in gene expression and cell growth (for recent reviews see e.g., Guerra and Issinger, 1999; Ahmed et al., 2000; Tawfic et al., 2001; Ahmed et al., 2002; Pinna, 2002; Litchfield, 2003; Pyerin and Ackermann, 2003). The kinase is localized to both the nuclear and cytoplasmic compartments in the cell, and undergoes dynamic shuttling between various compartments which may relate to its functional activity in those compartments (Ahmed et al., 1993; Tawfic and Ahmed, 1994a, 1994b; Tawfic et al., 1996, 1997; Guo et al., 1998, 1999a, 1999b; Ahmed et al., 2000; Faust and Montenarh, 2000). A key feature of CK2 cell biology is that it is essential for cell survival (e.g., Padmanabha et al., 1990), and accordingly, attempts to produce CK2-knockout mice have been unsuccessful (Bouchou et al., 2003).
The nature of existence of CK2 subunits in the cell is a subject of current investigations which have demonstrated divergent results (e.g., Guerra et al., 1999; Martel et al., 2002; Salvi et al., 2006). Regulation of cellular CK2 appears to be complex and various hypotheses have been proposed on this subject (for reviews, see e.g., Allende and Allende, 1995; Ahmed, 1999; Montenarh and Faust, 2000; Pinna, 2002; Filhol et al., 2004; Olsten et al., 2005). To explain some of our data on CK2 responses to altered cell growth, we originally proposed that CK2 undergoes dynamic shuttling between cytoplasm and nucleus and further within the nucleus it undergoes differential distribution depending on the conditions to which the cell is exposed (Ahmed et al., 1993; Ahmed, 1999; Tawfic and Ahmed, 1994a, 1994b; Tawfic et al., 1996, 1997; Guo et al., 1998, 1999a, 1999b; Ahmed et al., 2000). Subsequently, it was demonstrated that CK2 translocation can take place to other parts of the cell further reinforcing the notion that dynamic intracellular shuttling of CK2 might represent a key mode of its regulation in the cell in response to diverse signals (Tawfic et al., 1997; Faust and Montenarh, 2000). Analogous to these considerations is the emerging view that spatiotemporal organization of individual CK2 subunits in living cells involves multimolecular assemblies (Filhol et al., 2004), and that association of discrete subpopulations of CK2 may be regulated independently (Olsten et al., 2005). In this context, it is noteworthy that molecular downregulation of CK2 (e.g., by treatment of cells with antisense CK2 ODN) in cell culture or in vivo demonstrates a distinct reduction in the signal in the nuclear fractions such as chromatin and nuclear matrix (Faust et al., 2000; Wang et al., 2001; Slaton et al., 2004).
Much evidence exists supporting that CK2 signal is dysregulated in all the cancers that have been examined (for reviews, see e.g., Guerra and Issinger, 1999; Tawfic et al., 2001; Wang et al., 2006b). Interestingly, it appears that CK2 by itself is not oncogenic but rather it co-operates with other molecules thereby altering the oncogenic potential in the cell. Experimental transgenic mouse models of neoplasia in which altered CK2 signal served as a double transgene have provided significant support to this notion (e.g., Kelliher et al., 1996; Xu et al., 1999). The presence of elevated CK2 in cancer appears to correlate with the pathological status of the cancer and may serve as a prognostic marker (Yenice et al., 1994; Gapany et al., 1995; Faust et al., 1996; Faust et al., 1999; Piazza et al., 2006; Laramas et al., 2007). Although CK2 is present ubiquitously in all cells, it is noteworthy that its distribution in the normal versus cancer cells is distinct. In normal cells CK2 is localized in a diffuse pattern in the nuclear and cytoplasmic compartments whereas in cancer cells its distribution is characterized by a higher level in the nuclear compartment (Faust et al., 1999; Laramas et al., 2007). As indicated above, this difference in the localization of CK2 depending on the nature of the cell may be significant in regard to its function in cancer. Originally, it was unclear as to how elevated CK2 was involved in cancer cell biology considering that its activity is high in normal rapidly proliferating cells. This raised the question if CK2 increase in cancer cells was simply a reflection of their high proliferation. However, a comparison of CK2 immuno-reactivity with that of Ki-67 in the same tumor section revealed that both Ki-67 and CK2 signals were apparent in the proliferating edge of the tumor but the CK2 signal was additionally widely distributed in various cells in the section. This observation suggested that CK2 signal is not simply a proliferation marker but rather reflects the pathological status of the cell (Faust et al., 1999), and is further supported by recent immunohistochemical analysis of prostate cancer specimens (Laramas et al., 2007). Additionally, as discussed subsequently, our demonstration that CK2 is a potent suppressor of apoptosis (Ahmed et al., 2002) provided a novel link of CK2 function in cancer cell biology since it is well known that cancer cells not only demonstrate dysregulated growth but also dysregulated cell death. Thus, consistently elevated CK2 signal would not only contribute to altered cell growth and proliferation in cancer cells but also to suppression of cell death related activities.
Cell death is a complex phenomenon involving a variety of mechanisms. Of these, apoptosis (or programmed cell death) has gained considerable attention in regard to its potential significance in cancer cell death since it appears that dysregulation of apoptotic activity in cancer cells is an important feature of the cancer phenotype. Indeed, in certain cases, it may be even more significant than the dysregulation of cell growth (e.g., in the case of prostate cancer) (Kyprianou et al., 2000). Apoptosis in cells can be induced by a variety of means including, e.g., removal of growth and survival factors from the cells, treatment of cells with chemical agents, or treatment of cells with ligands for death receptors. We have investigated the involvement of CK2 in modulation of apoptosis induced by these various mechanisms.
One of the first studies on nuclear-associated protein kinase activity towards acidic nonhistone proteins employing the experimental model of rat ventral prostate subjected to altered androgenic status demonstrated that removal of the androgenic stimulus resulted in loss of phosphorylation of these proteins in the prostate which was very rapidly reversed in response to androgen administration in the animal (Ahmed and Ishida, 1971). Subsequently, we identified CK2 to play a significant role in phosphorylation of certain of these nuclear proteins (Goueli and Ahmed, 1991; Tawfic and Ahmed, 1994a, 1994b; Guo et al., 1998, 1999b); the variety of substrates of CK2 has expanded over time through investigations in various laboratories (for a review, see e.g., Meggio and Pinna, 2003). Our studies originally demonstrated that removal of the growth factor stimulus in the prostate gland (such as by androgen deprivation in the animal) resulted in rapid loss of nuclear CK2 such that it preceded the induction of apoptosis in prostate epithelial cells under these conditions. On the other hand, when growth stimulus was instituted by androgen administration in animals previously deprived of androgens there was a rapid shuttling of CK2 to the nuclear compartment of prostate epithelial cells prior to cell growth. Noteworthy was the observation that the translocated CK2 was differentially associated with the chromatin and nuclear matrix fractions in the nucleus (Ahmed et al., 1993; Tawfic and Ahmed, 1994b; Guo et al., 1998; Ahmed, 1999; Tawfic et al., 2001). Removal of growth factors from the culture media resulted in shuttling of CK2 from the nuclear to the cytoplasmic compartment and subsequent addition of the growth factors to the culture media demonstrated a reversal of this process with CK2 shuttling to the nucleus (Guo et al., 1999a). Further corroborative support for these considerations has been provided by recent documentation that nuclear accumulation of PTHrP (a key survival factor for cells subjected to apoptotic stimuli) effectively inhibits mitochondrial-mediated apoptosis through regulation of the expression, activity and sub-cellular trafficking of CK2 (Okoumassoun et al., 2007). Together, these observations point to a correlation of loss of nuclear CK2 to induction of apoptosis in response to removal of survival or growth factors whereas the reverse was the case upon administration of survival or growth factors. Thus, our observations provided the initial indication that dynamic changes in CK2 (especially in the nuclear compartment) play important role in cell growth and in cell death (Ahmed et al., 2000; Yu et al., 2001).
Further investigations of the involvement of CK2 in chemical mediated apoptosis demonstrated that treatment of cells with chemical agents such as etoposide and diethylstilbestrol which are well known chemical mediators of apoptosis caused an initial rapid shuttling of CK2 to the nuclear compartment presumably as a survival response of the cells. To provide a more direct confirmation of the role of CK2 as a suppressor of apoptosis we demonstrated that forced overexpression of CK2 prior to treatment of cells with etoposide or diethylstilbestrol strongly protected them against apoptosis (Guo et al., 2001). Analogous observations based on heat shock treatment of cells supported the role of CK2 in promoting cell survival (Ahmed et al., 2002; Davis et al., 2002), and subsequent studies employing radiation or UV treatment of cells have made similar observations (Kato et al., 2003; Yamane and Kinsella, 2005). It was previously suggested that CK2 may be involved in phosphorylation of ser-392 induced by UV damage of DNA (Keller et al., 2001). Recent documentation that CK2 mediates DNA repair following single strand damage (Loizou et al., 2004) may also be pertinent to regulation of cell death. Thus, it appears that CK2 impacts on apoptotic activity in cells mediated by chemical agents and also by physical stress.
An important means of induction of apoptosis in cells is via activation of the death receptor pathway. We and others have investigated the relationship between this mode of apoptosis and CK2, leading to the demonstration that CK2 impacts on apoptosis mediated by TNF-α, TRAIL, and FasL which bind to their cognate death receptors in prostate cancer cells (Wang et al., 2005a; Wang et al., 2006a) and other cancer cells (Ravi and Bedi, 2002; Izeradjene et al., 2005). To that end, we observed that when CK2 is moderately downregulated (by employing relatively low levels of chemical inhibitors of CK2 such as 4,5,6,7-tetrabromobenzotriazole (TBB) or apigenin or by molecular downregulation employing antisense CK2 or siRNA) there was a remarkable sensitization of cells towards death receptor ligands which under these conditions induced cell death at sub-optimal concentrations. Forced overexpression of CK2 impeded the effectiveness of the death receptor ligands in inducing apoptosis (Wang et al., 2005a; Wang et al., 2006a).
We originally demonstrated that treatment of cancer cells with antisense CK2 (or CK2 siRNA) resulted in potent induction of apoptosis (Faust et al., 2000; Wang et al., 2001; Ahmad et al., 2006). The induction of apoptosis was apparent when CK2 activity was reduced by 30–40% in the nuclear compartment (chromatin or nuclear matrix) (Faust et al., 2000; Wang et al., 2001). Recent studies by us (Wang et al., 2005b; Wang et al., 2006a; Ahmad et al., 2006; Ahmad et al., 2007) and by others (Ruzzene et al., 2002; Seeber et al., 2005; Pagano et al., 2007; Mishra et al., 2007; Hamacher et al., 2007) have also shown that chemical inhibitors of CK2 are effective in inducing cell death, and that induction of death by chemical agents is blocked by forced overexpression of CK2 (Wang et al., 2006a). Delivery of antisense CK2α into a xenograft prostate cancer in the mouse also demonstrated potent induction of apoptosis associated with significant reduction of the CK2 signal in the nuclear matrix (Slaton et al., 2004). Of note, analogous to results on the relation of nuclear CK2 to apoptotic signals are the observations that nuclear matrix-associated CK2 demonstrates discrete cell cycle related changes that are not apparent in the cytoplasmic compartment (Wang et al., 2003). Together, our studies indicate that a compartment of CK2 in the nucleus plays a key role in regulation of cell survival and death. The induction of apoptosis in vivo by intratumoral administration of antisense CK2 (Slaton et al., 2004), or a peptide that impairs phosphorylation by CK2 (Perea et al., 2004), has provided the proof of principle evidence for potential targeting of CK2 to produce cell death in vivo. Subsequently, we also originally reported that CK2 can be targeted by antisense CK2 delivered via the systemic route into the animal such that apoptotic response in tumor xenograft cells was observed in vivo (Ahmad et al., 2005). These observations have paved the way towards devising potential approaches to cancer therapy by targeting CK2 (Unger et al., 2004; Ahmad et al., 2005). It is noteworthy that chemopreventive dietary agents such as resveratrol and EGCG (epigallocatechin-3-gallate) which are known to have mild apoptotic activity in cancer cells appear to mediate this effect at least in part via targeting of CK2, raising the possibility of employing these polyphenolic compounds alongside sub-optimal levels of inhibitors of CK2 in combination chemotherapy (Ahmad et al., 2007). In the same context, it is noteworthy that multidrug resistance phenotype of CEM cells which are characterized by high CK2 level undergo reversion upon pharmacological inhibition of CK2 (Di Maira et al., 2007). Although concern persists regarding the potential of targeting CK2 for cancer therapy because of its ubiquitous nature, the aforementioned observations suggest an emerging interest in this signal as a therapeutic target. We are currently investigating an approach to circumvent the host toxicity issues by delivering the CK2 targeting agent encapsulated in a nanocapsule for delivery specifically to cancer cells in vivo (Unger et al., 2004; Ahmad et al., 2005; Wang et al., 2005b).
Mounting evidence suggests that there may be multiple nuclear and cytoplasmic targets that impact on the apoptotic machinery in response to modulations in CK2. For example, caspases 2, 3, 8, and 9 respond to alteration in the CK2 signal in diverse manners (Shin et al., 2005; Wang et al., 2006a). Procaspase-2 was shown to be a target of CK2 such that its dephosphorylation results in its dimerization and activation (Shin et al., 2005). ARC, a protein that inhibits caspase-8 activity when phosphorylated, has also been identified as a CK2 target (Li et al., 2002). The hallmark of nuclear apoptotic activity indicated by lamin A cleavage is strongly elicited by downregulation of CK2 and prevented by its forced overexpression (Ahmad et al., 2006; Wang et al., 2006a). Among the Bcl-2 family, Bid has been shown to be phosphorylated by CK2 (and also CK1) at serine residues in the vicinity of caspase-8 recognition site thereby preventing its cleavage by activated caspase-8 (Desagher et al., 2001). In a preliminary observation, we noted that forced overexpression of CK2 in ALVA-41 prostate cancer cells caused an upregulation of Bid (Ahmed, et al., unpublished results). Subsequent studies have shown Bid to be an interaction partner of the catalytic subunit CK2α (Olsen et al., 2006). In our studies employing TRAIL as inducer of apoptosis in prostate cancer cells, we have found Bcl-xL and Bcl-2 proteins to be sensitive to CK2 status altered by treating cells with chemical inhibitors of CK2 (Wang et al., 2006a). Inhibition or downregulation of CK2 results in loss of Bcl-xL and Bcl-2 proteins with Bax being upregulated, whereas overexpression of CK2 results in prevention of such changes in these proteins (Wang et al., 2006a). The engagement of the mitochondrial pathway is clearly indicated by the alterations in cytochrome c release upon downregulation of CK2 while it is blocked by overexpression of CK2 (Wang et al., 2006a). These various studies suggest that mitochondrial pathway plays a role in CK2 regulation of apoptotic activity and that certain of the Bcl-2 family of proteins in the apoptotic machinery are among the targets of CK2.
Attempts to identify proximal effectors of CK2 mediated modulation of apoptosis have revealed that intracellular H2O2 production upon downregulation of CK2 in prostate cancer cells may be an important signal for induction of apoptosis under these conditions (Ahmad et al., 2006). These studies have shown that downregulation of CK2 by employing chemical inhibitors of CK2 or antisense CK2α or siRNA for CK2α to achieve downregulation of CK2 in prostate cancer cells (both androgen-sensitive ALVA-41 and –insensitive PC-3 cells) results in rapid increase in intracellular H2O2 which may be responsible for triggering the downstream pathways resulting in release of cytochrome c, activation of caspase-3, downregulation of IκB, translocation of NF-κB p65, and subsequent DNA fragmentation. These novel observations implicate a relationship between reactive oxygen species and CK2 such that inhibition of CK2 may result in elevation of intracellular H2O2 leading to activation of its downstream targets in the apoptotic machinery (Ahmad et al., 2006). In this context, it is of interest to note that SAG (sensitive to apoptosis gene) protein which is upregulated on hypoxia induction undergoes degradation on phosphorylation by CK2 at Thr-10 (He et al., 2007).
Another locus of CK2 mediated modulation of apoptotic activity appears to be the inhibitor of apoptosis proteins (IAPs). Among these, survivin has been shown to be influenced by the CK2 status in cells (Tapia et al., 2006). In accord with these observations, ongoing work in our laboratory has also shown that survivin expression cIAPs expression is reduced in prostate cancer cells upon downregulation of CK2; further, we have observed that cIAP1, cIAP2, and xIAP are also engaged downstream of the CK2 signal (Ahmed et al., unpublished data).
Certain other genes that play a role in apoptosis are also affected by CK2. For example, in studies on TRAIL mediated induction of apoptosis, we observed downregulation of cFLIPL which was prevented by overexpression of CK2 in PC-3 prostate cancer cells (Wang et al., 2006a); the significance of this observation may relate to the recent documentation that cFLIPL expression is necessary and sufficient to maintain resistance to TRAIL-induced apoptosis in prostate cancer cells (Zhang et al., 2004). Upon phosphorylation by CK2, Max is rendered insensitive to cleavage by caspases (Krippner-Heidenreich et al., 2001) while Myc is stabilized by CK2 mediated phosphorylation (Channavajhala and Seldin, 2002). In the NF-κB pathway, downregulation of CK2 by employing antisense CK2α resulted in nuclear translocation of NF-κB p65 (Ahmad et al., 2006). Promotion of aberrant activation of nuclear factor-κB by CK2 in transformed phenotype of breast cancer cells has been documented (Romieu-Mourez et al., 2002; Eddy et al., 2005). Aberrant NF-κB activation by serum factors involving CK2 mediated activation of IKK2 has been reported in head and neck squamous carcinoma cells (Yu et al., 2006). Likewise, CK2 has been found to phosphorylate the Fas-associated factor FAF1 in vivo and influence its translocation to the nucleus (Olsen et al., 2003). A recent study has demonstrated that IGFBP-3 which is known to promote apoptosis in cancer cells is a substrate for CK2 mediated phosphorylation at ser-167, and that phosphorylation of this site by CK2 limits the ability of IGFBP-3 to induce apoptosis in prostate cancer cells (Cobb et al., 2007). Analogous to these studies is the recent documentation that PML tumor suppressor which controls key pathways of growth suppression, induction of apoptosis and cellular senescence loses can undergo phosphorylation by CK2 at ser-517 which results in its ubiquitin-mediated degradation. These authors also found an inverse relation between CK2 and PML protein level in human lung cancer (Scaglioni et al., 2006). PTEN, another important signal related to cell death and survival, appears to be stabilized on phosphorylation by CK2 (Vazquez et al., 2001). In this context, it is interesting to note that AKT (a protein kinase with a role in cell survival) which requires phosphorylation at Ser-473 and Thr-308 by cognate kinases for its activation also has been found to harbor a CK2-specific phosphorylation site at Ser-129 that appears to contribute to its hyperactivation (Di Maira et al., 2005). In a preliminary study, we also noted that forced overexpression of CK2 influenced AKT activation in ALVA-41 prostate cancer cells (Ahmed et al., unpublished data). Further support for the interaction of CK2 and AKT has been provided in a recent report (Guerra, 2006).
The brief overview of the functional activity of CK2 in the context of its ability to modulate cell death activity suggests that this signal has a broad ability to impact on diverse pathways engaged in the mediation of cell death. Fig. 1 depicts the dynamics of CK2 as involved in mediation of various functions in the cell under diverse conditions. As discussed above, a significance of these observations is that since CK2 downregulation by various means causes cell death, this approach has the potential of leading to novel strategies for cancer therapy. Studies in our laboratory are in progress along these line (Unger et al., 2004; Slaton et al., 2004; Ahmad et al., 2005; Wang et al., 2005b; Wang et al., 2006b).
Protein kinase CK2 is a ubiquitous and highly conserved protein serine/threonine kinase that is indispensable for cell survival. CK2 has long been implicated in cell growth and proliferation, and studies from several laboratories have suggested that CK2 plays a global role in affecting cell growth related activities. Recently, we documented that CK2, besides its role in cell growth and proliferation, can potently suppress apoptosis. Considering that CK2 has been found to be elevated in all the cancers that have been examined, the ability of CK2 to suppress apoptosis is particularly important in the context of cancer cell pathobiology since these cells exhibit dysregulation of both cell proliferation and cell death. Thus, overexpression of CK2 in cancer cells may impart a survival advantage by its action as a suppressor of apoptotic activity in these cells while promoting cell growth. In experimental studies, we have shown that overexpression of CK2 in cells can potently inhibit apoptosis mediated by a variety of agents including removal of survival factors, chemical and physical agents, and death receptor ligands. On the other hand, inhibition of CK2 by chemical inhibitors or by its molecular downregulation by antisense CK2 ODN or siRNA leads to potent induction of apoptosis. Downregulation of CK2 is associated with apoptosis mediated via effects on several downstream targets, and it appears that CK2 may have a global impact on the apoptotic machinery. While CK2 is present in both the nuclear and cytoplasmic compartments, several of its cell growth and cell death related activities appear to be associated with its signalling to the nuclear structures such as chromatin and nuclear matrix. In general, shuttling of CK2 to these compartments correlates with its role in cell growth and suppression of apoptotic activity whereas loss of CK2 from the nuclear structures is associated with induction of apoptosis and cessation of cell growth. These various observations on the biology of CK2 have led to our original proposal that CK2 is a potentially important target for cancer chemopreventive and therapeutic approaches; this is now being substantiated by recent studies.
The original investigations by the authors are supported in part by a U.S.P.H.S. Research Grant CA-15062 awarded by the National Cancer Institute, Department of Health and Human Services, and by the Medical Research Funds of the Department of Veterans Affairs.
Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


text:
Entry requirements
First- or upper second-class degree or an equivalent standard in other qualifications approved by the University in computer science or closely related discipline. You will require programming and mathematical knowledge to undertake this course. English language: IELTS 6.5, with minimum of 6.0 in each component.
Months of entry
Course content
There is currently a worldwide shortage of skilled practitioners in cyber security. Our MSc is specifically designed to give students a well-rounded, multidisciplinary view of the subject area, embracing not only the technical subjects, but also aspects of criminology, risk management, law and social sciences. The programme has been awarded provisional certification against the 'GCHQ Certified Master's degree in General Cyber Security' standard.
For further information, please visit our website.
Information for international students
Fees and funding
Qualification and course duration
Course contact details
- Name
- Physical Sciences and Engineering
- email@example.com
- Phone
- +44 (0)23 8059 2630

subset: commoncrawl


text:
Developing a loving bond with one's brother or sister becomes more complicated when they are diagnosed with autism. If a sibling cannot grasp what autism is, they will not know how to react when their brother or sister acts out. A sibling of a child with autism will react according to a few different factors, such as if the child with autism is older or younger, what examples the parents are setting for the children, and where the child with autism falls on the autism spectrum.
Studies from the University of Washington, in 2007, expanded on what these difficulties could lead to. They found that in some families, siblings to children with autism may draw from a smaller vocabulary or smile less at people they encounter throughout their day. Explaining to a child how large the autism spectrum is can be hard. What autism is in one family can be radically different in another.
Siblings may need to fight for attention from their parents, and deal with more tantrums than the average family; but if they keep an open mind, they can develop a healthy relationship with their brother or sister with autism.
Cathy Groschan, who works with the Kennedy Krieger Center for Autism and Related Disorders, says that, "if children view their parents and their peers as responding positively to their sibling's disability, and if they have good factual understanding of the disability, they tend to have positive relationships and a positive outcome."
Many children who have a healthy relationship with their sibling who has autism go on to work within the autism field, dealing with areas from research to awareness.


text:
About Traectorya Profesional, 2001 was the starter in the world of gastronomy in my country of origin Romania, after several years I decided to travel to Spain to discover more about the cuisine and decided to stay in this wonderful country, to learn and Teach my values between the stoves. The Food is a vital element for each of us.
Sunday, 19 February 2017
La Panacota o pannacotta es un postre tradicional en la gastronomía italiana, muy simple de elaborar que tiene tantas variantes como sabores queramos darla. Pásate a probar nuestra sabor de leche de coco....☺ 200 gr nata,200gr leche,200gr azúcar,8hojas gelatina lámina , 100 gr leche coco.
Posted by Nutu Daniel at 2/19/2017
No comments:
Subscribe to: Post Comments (Atom)


text:
Nearly three quarters of Winchester market town businesses offer an 'outstanding' or 'very good' customer experience
Press Release: 07/04/2016
Over 50 people representing retailers in Alresford, Denmead, Bishop's Waltham and Wickham are expected at an awards ceremony on 14 April in Bishop's Waltham to celebrate the results of 'Up Your Game, Up Your Gain' 2016.
The Winchester City Council funded scheme was designed to give the district's market towns a boost by offering a helping hand to those retailers and service providers whose businesses would benefit from further enhancement in their customer experience offering
40 independent businesses were visited by mystery shoppers who rated them on a range of factors including window display, interior layout and customer service.
Those businesses whose overall score demonstrated their ability to offer an outstanding customer experience will be recognised at the awards ceremony, with trophies for the two highest scoring businesses over all four towns, and a trophy for the overall highest scoring town.
Jim Smith of Shopper Anonymous, who carried out some of the surveys, said:
The results show that all of the towns have a high number of shops and businesses that give customers a great experience, a vital factor if visitors are to return. Repeatable footfall is what all High Streets crave, so this is great news for retailers who suffer intense competition from bigger neighbours and the internet. I'm looking forward to the results being announced on 14 April.
Heidi Isa, Market Towns Development Office for Winchester City Council said:
Having had a preview of the results, my conviction that our market towns offer customers an unrivalled shopping and dining experience has been reaffirmed. I'm immensely proud to be working among such a great group of businesses offering such fantastic customer service.
After the awards ceremony, all businesses who took part in the scheme will receive a full report on their results as well as a one-to-one session with a customer service expert. This will allow them to further enhance their customer experience offering, resulting in the highest standards of customer service across all four towns.


text:
The Mecum Kissimmee Auction, the world's largest collector car auction, returns to Osceola Heritage Park on January 6-15. More than 60 acres are covered in 3,000 collector cars and more than 1,000 Road Art items for 10 days of auction. The event is massive; its size and subsequent variety are unparalleled. The Kissimmee 2017 lineup will include everything from entry-level collector vehicles to multi-million-dollar investment pieces.
When you're being bedazzled, or bidding on the coolest hot rods and pristine classics at Mecum - experience some of Kissimmee's old town charm, entertaining night life and heart-pounding attractions. Plus you're just minutes from the world famous theme parks.
Click here for more auction information and preferred lodging.


text:
- Average
- Main course: د.ب.12
- Food spend: د.ب.24
- Opening hours
- Monday to Saturday: 12:30 - 14:45 & 19:30 - 23:30
Offering a journey of discovery through the country's traditional dishes, Golestan Restaurant conjures the flavours of Persia.
Enjoy fresh oven-baked breads served at the table, followed by a variety of salads, main dishes and rice, delicately flavoured with saffron and dried pomegranate just to name a few.
Golestan at Sheraton Bahrain
Po Box 30, 6 Place Ave, ., Manama
See all restaurants in Manama
Book this restaurant
Select a tableClosest available times
Menus available at
Sorry, there are no tables available for 2 people on this date.
Try searching for an alternative date.
Sorry, there was an error completing your search.Search again
Loading availability
Nearly done! Please enter your details
- Guests:
- Date:
- Time:
- Menu:
Your Contact Details
- Name:
- Email:
- Phone:
Booking confirmed
An email confirmation has been sent to email@example.com
- Guests:
- Date:
- Time:
- Menu:
There was an error completing your booking.
Find a new table
Deals direct to your inbox!
Hear about our top offers first & book the best tables
You're done!
Great deals coming your way soon
Nearby restaurants
3541m 0 reviewsFURN Bistro & Bakery
FURN Bistro & Bakery


text:
Chapter One
The Electric Interruption
Peter's icy fingers wrapped around the head of his cock as it began to harden. He watched the computer screen where two men sat next to each other stroking away. Both looked off to the right at what he assumed was a tv. The light from the tv danced across their faces, tip toeing on their parted lips and drooping eyelids.
Peter began to stroke his cock when they did. He started off slowly, lightly tapping on the tip and playing with the corona, circling it with his forefinger. He continued to do this until his dick began to jump at the touch; the senses heightened and the nerves excited. It helped that his fingers were nearly frozen. The heater broke again, and the near zero temperatures of Brooklyn had seeped in his apartment walls.
The men quickened their pace, and Peter attempted to match it. His hand would slide up as their hands would slide up. His hand would slide down as their hands would slide down. All three began to pant, bright red lips quivered, and eyelids fluttered. Abs clenched and unclenched. Biceps bulged and thighs tightened. Muscles contracted and released. Strokes became more frantic; large hands sliding up slippery shafts, around the head, and down the shaft again. Skin slapped against skin as hands angrily collided with the base of thick cocks. Right arms went behind heads as mouths turned into O's. They could feel it coming. The tight swirling in the lower abdomen began to grow stronger and balls clenched. The universe stopped moving as their cocks filled with energy ready to blow.
The lights in the apartment suddenly flashed and the computer screen vanished. Peter's hand froze mid-shaft as he stared at the black screen. The power had gone out.
"Fuck!" Peter said under his breath as he was pulled back from the two men and into the reality of his one-room apartment. "Fuck, fuck, fuck. Why now?" he said to himself. Dealing with the loss of what could have been the best orgasm of his life, he lay in bed, eyes staring at the stained ceiling, hands to the side. His cock continued to twitch.
After a few minutes, and what felt like the five stages of grief, he sat up and closed his laptop. "Sorry buddy, looks like you're going to have to wait," he said to his erection and sat up. Reaching over to his bedside table, which happened to also function as a dining table, he grabbed a palm-sized leather-bound notebook. He untied the strings, opened the book, and flipped through pages. Each page had two names on it and a brief description of what their asshole's felt like, how big their dicks were, and a number rating them out of ten. These weren't his writings.
The first five pages were the records of Joey Noble. He was Peter's best friend in high school. Joey was a junior when Peter was a senior. So when Peter left to move to Brooklyn, Joey wanted to give him a piece of himself. He handed Peter his Fuck Book. During the semester, Peter found himself reading the scrawled entries over and over.
Dalton Bishop 7/10
6in. cock, short but thick. Large arms and bulging pecs. On our
basketball team. He approached me in lockers. Took my cock
in his hole on his hands and knees. Jerked him off as I fucked
him from behind. Very hairy. Power bottom.
Peter enjoyed picturing Joey taking another boy from behind, but also felt a tinge of jealousy. All the boys Joey stuck his dick in were Peter's old classmates. He turned eighteen at the beginning of senior year, so his options were very limited in high school.
Peter flipped through the next few pages where he began to make entries a few months back when he started college. He only made four and none of them were particularly good. One was a seven, the rest fives. He considered them practices, not "the real thing". 0.1 through 0.4. But he knew who may be his first #1. Last night, he wrote in a new name; Zach. He hadn't fucked the guy yet, but he planned on it.
Peter put the book down, and picked up his cell phone lying next to the book, quickly tapping the landlord's number. The phone rang a few times until the landlord finally picked up.
"Peter? Do you know what time it is?" the landlord said incredulously.
"I wouldn't need to call if you paid the damn electricity bill," he retorted.
"Why do you care? It's 3 in the morning." Peter hesitated and looked down at his fading erection feeling a deep sadness.
"I was… in the middle of something, then the power cut off. And don't get me started on the heater."
"Well, if your rent was on time, maybe I would've paid the bill."
"Yeah, well, go fuck yourself," he said and then hung up. Peter sighed deeply and then redialed the landlord. "Zach, I'm sorry, I didn't mean that."
"I know Peter," he said. "Get to sleep." Then he hung up. Peter put his phone down and sighed. Well, there's always a next time, he thought. He didn't continue masturbating because once you're interrupted, it won't be perfect. And every jack off should be perfect.


text:
- You are here:
- Home
- →
- Fitness
- →
- Build Muscle
- →
- Pull Up Or Chin Up?
Pull Up Or Chin Up?
By MH Staff - Posted on 7th February 2014
Which exercise you should do depends on which muscles you want to target, say researchers at the University of Salford in England. Here's how the two moves stack up.
1 Pull Up (Overhand Grip)
Compared to the chin-up, the pull-up better activates your lower traps – key players in the quest for a V-shaped torso. It also works your lats and infraspinatus muscles, which help rotate your shoulder joints.
2 Chin Up (Underhand Grip)
Although technically a back exercise, the chin-up also activates your biceps and pectoral muscles. If you find pull-ups too hard, give chin-ups a try.


text:
Jan. 23, 2012
Laramie, Wyo. -
What other sports did you play throughout your childhood and high school years?
When and why did you choose wrestling?
How does your family support you?
What is a typical day of practice for you?
How do you balance school and wrestling?
What do you want to do with a Kinesiology and Health Promotion degree?
What changed from high school to college wrestling?
What are some daily pressures you deal with every day?
What are your goals for the rest of this season?
What do you wish to accomplish before you graduate from UW?
Why did you redshirt the 2010-2011 year? What advantages do you feel like you gained from this decision?
What is your most memorable collegiate meet?
How do you prepare for each meet?
What qualities will you take away from the program?


text:
Free Stuff, Samples, Coupons, and Sweepstakes | Woman Freebies
May 21, 2015 | Videos
I can relate to this poor puppy. I'm not a fan of the hiccups either!
You work too hard for your money to throw it all away on full price when you don't have to!
© adjump 2011 All Rights Reserved No part of this website or any of its contents may be reproduced, copied, modified or adapted without adjump's prior written consent.


text:
What is JotForm?
JotForm is a free online form builder which helps you create online forms without writing a single line of code. No sign-up required.
At JotForm, we want to make sure that you're getting the online form builder help that you need. Our friendly customer support team is available 24/7.
We believe that if one user has a question, there could be more users who may have the same question. This is why many of our support forum threads are public and available to be searched and viewed. If you'd like help immediately, feel free to search for a similar question, or submit your question or concern.
FormsCentral Migration: Only forms were imported but no dataAsked by borneol on February 12, 2015 at 02:11 PM
I use migration tool for formscentral forms and data but only forms were imported. I had well clicked on import both forms and responses.
Could you please tell me why?
This is a re-post of a comment on Import Your Forms and Responses In A Single Step From Adobe FormsCentral
We apologize for this inconvenience.
The jobs are queued and processed in the order they arrive. So data might take more time than forms to be imported.
Could you please let us know if you entered your request today?
Our engineers are working hard to expedite this process and reduce any delays in it.
We appreciate your patience.
Thank you.
Hi Raul,
Yes, I entered my request today, after a few seconds I hab my forms imported.
Ok, thank you for confirming.
Please allow some time for the data to be imported to your account.
You'll receive an email once the process is completed.
Could you please tell me why my datas were not yet imported?
Thank you
JotForm Support
Apologies for the inconvenience that this might have caused you. Upon checking your account, it seems that forms are imported, although there are quite a lot of duplicates. I can't seem to find in our records failed or pending form responses that is being migrated.
Could you please share us the Adobe ID of some of the forms?
Another thing that you can do is you can import the responses directly to JotForm using the Import App. Here's a guide on how to do that: http://www.jotform.com/help/309-How-to-Migrate-Form-Data-from-Adobe-FormsCentral-to-JotForm. You can follow Method 2.
I hope that helps.
Kind regards.
Hi !
It's ok now. I have deleted older form and imported again and everything is ok.
Thank you
JotForm Support
I'm glad to hear that re-importing resolved the problem.
If you needed any assistance again, please do not hesitate to create a new thread here in the forum.
Thank you.


text:
This is a top-level category for content related to Organization of the Society. Individual articles should generally not be placed in this category, but rather should be placed in sub-categories of this category. For an overview of the category structure, go to the Category Index.
This category has the following 5 subcategories, out of 5 total.
- [+] Jesuit assistancies (10 C)
- [+] Jesuit communities (14 C)
- [×] Jesuit conferences (empty)
- [+] Jesuit provinces (93 C, 2 P)
- [+] Jesuit residences (14 C)


text:
What can we do other than controlled crying? (long)(12 Posts)
stollibolli Fri 25-Oct-13 21:18:52
HarderToKidnap Fri 25-Oct-13 21:20:16
CreatureRetorts Fri 25-Oct-13 21:21:31
RandomMess Fri 25-Oct-13 21:21:57
stollibolli Fri 25-Oct-13 21:47:43
RandomMess Fri 25-Oct-13 21:53:56
Patchouli Fri 25-Oct-13 21:59:37
Theonlyoneiknow Sat 26-Oct-13 15:37:11
Theonlyoneiknow Sat 26-Oct-13 15:39:37
stollibolli Sat 26-Oct-13 21:49:06
Join the discussion
Registering is free, easy, and means you can join in the discussion, get discounts, win prizes and lots more.Register now
Already registered with Mumsnet? Log in to leave your comment or alternatively, sign in with Facebook or Google.
Please login first.


text:
Sales Assistant
- Recruiter
- Baby Land (uk) Ltd T/a Baby Pl
- Location
- Derby, Derbyshire
- Salary
- Good Rates of Pay
- Posted
- 07 Aug 2017
- Expires
- 04 Sep 2017
- Sector
- Retail & Wholesale, Sales
- Contract Type
- Permanent
- Hours
- Full Time
Sales Assistant
The UK's largest independent nursery retail store now open in Derby, we are looking for enthusiastic, hard working and dedicated full and part time retail sales assistants.
If you like the sound of working for the fastest growing independent nursery retailer, to be a part of a great retail team and have the enthusiasm & dedication to work your way up, please call into store to collect a job application form.
Retail sales experience is essential, but we will provide on the job industry training. We will offer a rate of pay to match your experience.
Please send your CV by clicking apply
Apply for Sales Assistant
Already uploaded your CV? Sign in to apply instantly


text:
Let's keep it short, let's keep it simple... battle of the bands (or artists, I don't want to be politically incorrect) day 4. Today we got a song I personally love so let's just get right to it.
Today's battle: Black Sabbath VS. Bullet For My Valentine
Sing Title: Crazy train.
Black Sabbath
Bullet For My Valentine
- Black SabbathVote A
- Bullet For My ValentineVote B
Select a gender to cast your vote:
I'm a GirlI'm a Guy
Most Helpful Girl
Oh, please. Black Sabbath all the way!00|00|0


text:
Popular Now
Popular Now
Popular Now
Popular Now
01803 865913
+44 1803 865913
Series: Bonn Zoological Bulletin - Supplementum (formerly Bonner Zoologische Monographien) Volume: 15
By: Wolfgang Scherzinger(Author)
66 pages, b/w photos, b/w illustrations, tables
Zoologisches Forschungsmuseum Alexander Koenig
Language: German with English summary
This monograph reports on ethological studies on reproduction and development of the ural owl (Strix uralensis), compared with the tawny owl (Strix aluco)
There are currently no reviews for this product. Be the first to review this product!
Your orders support book donation projects
We find their customer service to be excellent
Search and browse over 110,000 wildlife and science products
Multi-currency. Secure worldwide shipping
Wildlife, science and conservation since 1985


text:
Special mix 12 pcs. from quality 3" shells by Super Power!
- 2 pcs. Golden Palm Tree w. Silver Strobe Pistil
- 2 pcs. Red Strobe
- 2 pcs. Red Coconut Tree w. Orange Strobe Pistil + Silver Tail
- 2 pcs. Silver Strobe to Colorful Peony w. Silver Tail
- 2 pcs. Blue Peony w.Silver Strobe Pistil w. Silver Tail
- 2 pcs. Blue Swimming Star
CE certificated (Meets the legislative requirements of the EU.)
By buying you acknowledge that you know how to handle with this cathegory according to rules in your country.
66.00,- €


text:
Resolute was the name of several different Star Destroyers of varying types that were in operation during the Clone Wars, before and during the Galactic Civil War, and the during the Second Galactic Civil War.
- Resolute, a Galactic Republic Venator-class Star Destroyer that took part in the Clone Wars.
- Resolute, an Imperial Navy Imperial-class Star Destroyer that responded late to a Rebel attack on a convoy during the Galactic Civil War.
- Resolute, a Corporate Sector Authority Invincible-class Dreadnaught Heavy Cruiser used by early on in the reign of the Galactic Empire.
- Resolute, a Galactic Alliance picket destroyer that took part in the Blockade of Corellia during the Second Galactic Civil War.
- Resolute, a starship of the Fel Empire that fought at the Battle of Caamas.
This is a disambiguation page—a navigational aid that lists other pages that might otherwise share the same title. If an article link referred you here, you might want to go back and fix it to point directly to the intended page.


text:
pokot girl Posters and Art Prints
Search in: Artworks (2)
You are currently viewing all works. Here you find poster, art prints, prints on canvas and greeting cards. Works that are tagged with pokot girl only make up a small part of our range of high quality art works. Of course on pokot girl items we offer customer satisfaction guarantee as well.
from the gallery of John Warburton-Lee Photography
from the gallery of John Warburton-Lee Photography


text:
Tall Tale Shopping
It looks like you have an ad blocker on. Please disable your ad blocker and refresh to fully enjoy our games.
Thank you.
Do you have any friends that tell you just an unbelievable story about the latest and greatest deal they've ever gotten? I had a friend that just told me she bought three outfits for under $20. So I told her to bring to this magical shopping mall. Do you want to come, too?
Use your mouse to click on and through the floating hair, clothing, and accessory options.


text:
+7 (812) 320-63-63, firstname.lastname@example.com
Indirizzi tematici
- Progetti culturali
- Investment activities
- Industria del legno
- Industria del mobile
- Gas e petrolifera, settore combustibili e materie prime
- Industria alimentare, imballaggi
- Tecnologie industriali, scienze, metalmeccanica
- Turismo e MICE
- Medicina, biotecnology e industria farmaceutica
St. Petersburg International Energy Forum opened on Sept 18th, 2012
On September 18th, the 12th St. Petersburg International Energy Forum launched its work with a plenary session specially devoted to further development of the global and Russian power industry. The event is attended by over 500 delegates from 13 countries, including Russia, Belarus, UK, China, Germany, Spain, Canada, the Netherlands, Norway, Poland, Slovenia, US and Finland.
During the session, Deputy Energy Minister Pavel Fedorov assured that the tax reform in the oil and gas sector will be continued. By loosening fiscal policy, we attract investors. Otherwise, in the long term, production volume of raw materials will fall so that Russia risks losing its status of energy superpower. Over the recent years, the country has run only three new projects for field development due to specific targeted benefits to investors only. This September the Department of Energy promises to provide new rules, which are already applied to the key players in the market, – the so-called uniform methodology for stimulating new projects launch.
Pavel Fedorov, Deputy Energy Minister of Russia:
"We have quite a number of fields that should work, – to do so we need to adapt the regulatory framework, fiscal management conditions in order to create motives for the owners of these deposits to invest under consolidated methodology, to attract capitals – in accordance with the highest international standards". To watch video by 100TV>>>
The Forum discussion are supported by thematic exposition at Lenexpo Fairgrounds, covering all aspects of the energy industry, such as exploration and production of energy resources, processing and transportation, power generation and distribution, as well as the manufacture and application of modern power equipment – MIRR, Renewable Energy, Offshore-expo, Neftegasexpo, Oil Refining and Petrochemical Industry, Nuclear Industry, Power Machine Engineering, Transenergoexpo.
Among the participants of the exhibitions are the most authoritative local companies and multinational corporations, including Arcticmorgeo, Baltnefteprovod, Voronezh Mechanical Plant, Gazprom, Gazprom Salavat Petrochemical, Izhora Plants, Inter RAO UES, Rosenergoatom, Neftegazmontazhservis Sevmash, Power Machines, FMC Technologies, etc.
The event lasts till September 20th, 2012. Forum Sponsors: LLC "Neftegazmontazhservis", OAO "Gazprom", JSC "Gazprom Salavat Petrochemical", OOO "Gazprom Transgaz St. Petersburg", Cameron, Shell, Wintershall.


text:
European car market records solid start to the year
The flipside to December 2005's lower than expected incentives boost to the European new car market was that there was as a consequence less 'payback' in January. Indeed, the January market turned out to be 2% ahead of last year's - a solid result overall. There were relatively strong starts in a number of national markets, including Germany. This analysis is from JD Power-LMC.
Get full access to all content, just $1 for 30 days
A Message From The Editor
just-auto gives its paid members access to the very best automotive market coverage.
And now there's just-auto plus, our premium membership that gives you exclusive component forecast data, company profiles and extended news coverage - just for premium members.
Today I can offer you 30 days access for $1 - and that includes just-auto plus.
Dave Leggett, editor of just-auto
* plus VAT if applicable
Only on


text:
Yangtze Gold 6
Yangtze Gold 6, one of the TOP DELUXE Yangtze Gold Cruise Ships, sails from Chongqing to Yichang every Saturday and from Yichang to Chongqing every Tuesday.
Cruise Route:
Chongqing - Yichang (4 days & 3 nights)
Yichang - Chongqing (5 days & 4 nights)
Price: $452-$569
•This price range is based on a standard cabin for twin sharing.
•The prices are valid until Feb.28, 2018.
•Please enquiry for the exact price according to your nationality, cruising time and cruising route.
•Please quote us for the price may change during China's Golden Week (the first week of October) and Spring Festival.
Ship Overview
Yangtze Gold 6, the sister ship of Yangtze Gold 2, took her maiden voyage on June 4th 2012. Being the top largest and new cruise ship, Yangtze Gold 6 is specialized to provide the really deluxe enjoyment to a maximum of 570 guests regardless of where they come from. It has a series of world-class facilities and places to benefit and highlight your stay onboard, with 216 comfortable and well-decorated cabins and suites, grand restaurants, sauna & massage areas, gym center, internet café, children's playing center, swimming pool, shopping areas, and so forth. Besides, food and beverages are also prepared in good quality to please your taste buds, and multiple kinds of activities and fun are arranged during day and night, so you will feel a trip to the Yangtze River on Yangtze Gold 6 is really wonderful.
- Maiden Voyage: June 4th, 2012
- Passenger Capacity: 570
- Total Cabins: 216
- Decks: 6
- Elevators: 3
- Dining Halls: 3
- Itinerary: Chongqing - Yichang; Yichang - Chongqing
Why Choose this Ship?
We booked our cruise with Johnson Wang, in the Chengdu office. He was very efficient in every detail of our trip and in answering all of our questions and handling our special requests regarding transfers promptly. Would definitely recommend using him as your agent. The trip itself was the three day trip from Chongqing to Yichang, on the Gold Cruise 6. Great staff. Very friendly and accommodating. The scenery is spectacular and the cruise is very smooth. We signed up for all of the day trips to the historic sites, and although that was quite tiring, we were happy that we did them all. There was an English speaking guide assigned to us for each stop and also for all of our services on the cruise (dining, housekeeping, cruise director etc). Even with the language barriers with most of the other guests, we were all good friends and had a warm send off from everyone at the end of the trip.
- ---- Reviewed by twiggyS69, Dec. 19, 2016
We contacted Lyn at Yangtze river cruises and she was very helpful! She answered all our questions and also arranged pick up and traintickets after ended cruise. Very good service! We went with the Yangtze gold 6 ship. It was a great ship, the only thing we wished we knew was that this cruise was mostly for Chinese tourists. So we were a little lost as the only western people there. But the cruise management on the boat took very good care of us so we had a great and fun tour. Would absolutely recommend Yangtze river cruises for planning a trip on Yangtze river.
- ---- Reviewed by Anne S, Nov. 5, 2016
An amazing cruise from the 3 gorges dam, the wolds largest hyroelectic project on the beautiful Yangtze Gold cruiseship.
This trip was absolutely amazing, scenery was unbeliveable through the gorges, something different every day on this 4 days cruise.
- ---- Reviewed by Erieau, May 13, 2016
Know More about Shore Excursions & Attractions
No documents found.
2016 Schedule of Yangtze Gold 6
- 2016
- 2017
- Jan.
- Feb.
- Mar.
- Apr.
- May.
- June.
- July.
- Aug.
- Sept.
- Oct.
- Nov.
- Dec.
• The above price range is based on a standard cabin for twin sharing.
• The prices are valid by Dec.31 of the year.
• Please enquiry for the exact price according to your nationality, cruising time and cruising route.
• Please quote us for the price may change during China's Golden Week (the first week of October) and Spring Festival.
Other Ships of this Company
Save up more to Book a China Tour Package including Yangtze Cruise
- 1 5 Days Yichang Tour with Yangtze Cruise Experience (Yichang / Yangtze Cruise / Chongqing) from request
- 1 4 Days Chongqing Essence Tour with Yangtze Cruise (Chongqing / Yangtze Cruise / Yichang ) from request
- 1 6 Days Chongqing, Yangtze River & Zhangjiajie Exciting Tour (Chongqing / Yangtze Cruise / Yichang / Zhangjiajie) from request
- 1 11 Days China Golden Triangle Tour with Yangtze River Cruise (Beijing / Xian / Chongqing / Yangtze Cruise / Yichang / Shanghai) from $1979
Have a question? Get answers from our travel experts or guests
- Your Question:
- Your Name:
- Your Email:
- Submit


text:
Question: Equity capital on the balance sheet is reported using historical
Equity capital on the balance sheet is reported using historical cost accounting and at times differs considerably from market value. How should our analysis allow for this, if at all, in analyzing capital structure?
View Solution:
View Solution:
Answer to relevant QuestionsWhy is the evaluation of asset composition useful for capital structure analysis? Comment on the following assertion: "Debt is a supplement to, not a substitute for, equity financing."Since cash generally does not yield a return, why does a company hold cash?The Lux Company experiences the following unrelated events and transactions during Year 1.The company's existing current ratio is 2:1 and its quick ratio is 1.2:1.1. Lux wrote off $5,000 of accounts receivable as ...Reproduced below are selected financial data at the end of Year 5 and forecasts for the end of Year 6 for Top Corporation:Additional forecast estimates for Year 6:Sales. . . . . . . . . . . . . . . . . . . . $412,500 Net ...
Post your question


text:
A industry source claims that superstar Pawan Kalyan tests the patience, perseverance and creative skills of directors, before giving them a chance to direct him, but it seems that writer-turned-director Bobby is an exception.
Top Tollywood directors from director Karunkaran to Arunprasad, from Puri Jagannath, Harish Shankar, every director had to get 'tuned to his style of making' in months of their 'discussions and sittings', to enable Power star to judge his talent and give him a chance or not.
Even Sampath Nandi after superhit "Rachcha" had to spend more than 12 months with the Puli star and struck a chord, but it is surprising, how he was replaced with Bobby, in matter of few weeks. "Bobby was never in the contention and even Pawan himself was thinking of directing the sequel of the cop story, but out of the blue, Bobby name
cropped up and finalized" says the source.
Of course, Bobby's directorial debut "Power" just showed traces of his handling a star, but still had lot of loopholes, but Pawan overlooked everything? Or to help his friend Sarath to turn producer? Why took a fast decision?


text:
My boyfriend loves horror movies and I don't particularly care for them. I prefer psychological thrillers and his favorite movie is jeepers creepers. Does that say anything about his personality or inner self? I know for me, I love psychological thrillers because of the suspense and the mind fuck you experience within the movie. I like action, along with something to think about but horror? Blood? Gory scenes? I hate that.
What does it say about a person if the love horro movies?
Have an opinion?
What Guys Said 1
that he's a cold bloded psycho murderer that's just waiting for the next victim
seriously though, it says nothing else than that he loves the adrenaline thrill of it. And we all love that thrill, it's just how we get it that varies from person to person.00|00|0
What Girls Said 2
It just means he likes a certain genre of movies, and so do you. There's no real underlying meaning to it really.00|00|0
I love horror movies, but not all. I prefer more of the supernatural ones over just gore. I'm not sure what that says about a person. I don't want bad thing to happen, but I like watching people rise up against something truly evil and terrible.11|00|0
This makes sense. Thank u
Sure, no problem!
Learn more
Select as Most Helpful Opinion?
You cannot undo this action. The opinion owner is going to be notified and earn 7 XPER points.


text:
|Varundeep Kaur - Dharam keeps you charged up at work and to every proble...
Mr. Dharamjeet Taunque
Mumbai-India, Maharashtra - India
About Mr. Dharamjeet Taunque
All India Head - Usage and Retention for Prepaid and Postpaid at IDEA Cellular Ltd.. I am analytical proactive and i take initiative. I am an optimist and believe in honesty and integrity.
If you notice offensive or incorrect information, please contact us.
Mr Navendu Sharma
Telecom Industry@
Lifetree Convergence Ltd


text:
Find us on Twitter Facebook Pinterest Google+ Bloglovin'
Sunday, 21 February 2016
Silent Sunday
Find us on Twitter Facebook Pinterest Google+ Bloglovin'
9 comments :
Aw beautiful photo! Thank you so much for participating in the new #SilentSunday! :)ReplyDelete
That is so calm and I love that you can even see his legs underwater. Do come and link him up to #AnimalTales on Tuesday if you want!ReplyDelete
Beautiful shot :)ReplyDelete
He looks content.ReplyDelete
Thanks for linking up to #AnimalTalesReplyDelete
this looks so amazing ♥ReplyDelete
Aww, beautiful shot :)ReplyDelete
Lovely colours!ReplyDelete
Great shot here!ReplyDelete
I hope you'll join us and link up at this week's photo party at http://image-in-ing.blogspot.com/. It opens as Tuesday dawns "down under" and remains open all week long!
Thanks for taking the time to comment, we appreciate it!
Comments will usually be visible after moderation.
Subscribe to: Post Comments ( Atom )


text:
Actress and model Meg Phillips was born in Jacksonville, Florida. She grew up traveling the US, eventually settling in southern New Jersey for High School. She has attended Fordham University, as well as the American Musical and Dramatic Academy (AMDA) in New York City. Moving to New York in order to pursue an acting career, she soon landed the lead role of Pinkalicious in the successful Off-Broadway play of the same name and toured the USA with the company as well. She has also worked as a model in New York City.
The diminutive, vivacious Phillips, often called "Megz," has recently broken into the movie business with supporting roles in such films as "The Smurfs" and "Bachelorette".
Name: Meg Phillips
Known for: Noah


text: 2. As of noon trading, Republic Services ( RSG) is up $0.40 (1.2%) to $33.83 on light volume. Thus far, 491,123 shares of Republic Services exchanged hands as compared to its average daily volume of 2.0 million shares. The stock has ranged in price between $33.47-$33.94 after having opened the day at $33.48 as compared to the previous trading day's close of $33.43. Republic Services, Inc., together with its subsidiaries, provides non-hazardous solid waste collection, transfer, and recycling and disposal services for commercial, industrial, municipal, and residential customers in the United States and Puerto Rico. Republic Services has a market cap of $12.1 billion and is part of the industrial goods sector. Shares are up 0.7% year-to-date as of the close of trading on Thursday. Currently there are 4 analysts who rate Republic Services a buy, no analysts rate it a sell, and 5 rate it a hold. TheStreet Ratings rates Republic Services as a buy. The company's strengths can be seen in multiple areas, such as its growth in earnings per share, increase in net income, revenue growth, attractive valuation levels and expanding profit margins. We feel these strengths outweigh the fact that the company shows weak operating cash flow. Get the full Republic Services Ratings Report now. 3x UPSIDE POTENTIAL: TheStreet Quant Ratings has identified a handful of stocks that can potentially TRIPLE in the next 12 months. Learn more.


text:
Alessi Presto DCM01SET Moka White 2-Cup Italian Espresso Cups
Price: $165.00
Code: italian-presto-moka-cup-set
Alessi Presto Moka White 2-Cup Italian Espresso Cups
Classic Italian "Mocha" Cup Set with Saucers by Denton Corker Marshall
Designer: Denton Corker Marshall
Manufacturer: Alessi
> Free Shipping > 110% Price Match > No Sales Tax
Alessi Presto Moka White 2-Cup Italian Espresso Cups allows you to enjoy your cup of Espresso or Mocha the real authentic Italian way. This classic Italian "Mocha" Cup Set with matching Saucers was designed by Denton Corker Marshall and is made by Alessi in Italy. A best selling Espresso Cup set, each is expertly crafted in Italy for an authentic feel and look. Set includes (2) each: 3 ounce single-shot espresso cup with matching saucer. Each cup is about 2.5 x 2.5 x 2.5 inches.
Collection: Alessi
Alessi Product Code: DCM01SET
Material: white bone china
Dimensions: 2.5 x 2.5 x 2.5 inches each cup
Capacity: 3 oz each cup
Use: Kitchen
Product Category: Espresso Cups
View all from Denton Corker Marshall
View all from Alessi
In Stock.
Usually ships in 1 business day.
Free shipping, insurance, tracking number!
110% Low Price Match Guarantee on Alessi design*!
No additional Sales Tax on Alessi design*!
Friendly and Knowledgeable Customer Service!


text:
Correspondendo a: cold X
- Classificar por:
- Data ▼
- Título
- Curtir/Votos
- Comentários
- Visualizações
DB2 10: Multi temperature data management Blog da Comunidade
SergeRielau Marcações: 10 ssd hot db2 cold data multi warm partitioning range management temperature 3.916 Visualizações
Truisms: SSD is fast SSD is expensive HDD are big HDD are cheap DB2 10 boasting a new and exciting feature which helps you place your data where it is most cost effective. Multi temperature data management not only allows you to place data at the most...
do Blog: developerWorks India
DB2 10: Multi Temperature Data Management
SergeRielau Marcações: storage range temperature cold multi hot warm data partitioning 6 Comentários 9.264 Visualizações
Motivation A few years ago I sat in a customer briefing and the customer representative summed up their database philosophy as "pack rats". What she meant was that the data warehouse is ever growing at a high rate and nothing ever gets deleted. Over...
do Blog: SQL Tips for DB2 LUW
Cloud Commerce: Tailor Your Commerce Strategy via Cloud Solutions Blog da Comunidade
Wes_Simonds Marcações: cream economy software ice cloud cold e-commerce coremetrics ibm sterling unica ilog smarter-commerce computing hot capability 1.163 Visualizações
Someone recently asked me how it was possible that cloud computing began to take off at just about the same time the economy got cold -- circa 2008. This argument had a culinary simile: that major new technology shifts (such as cloud) are like ice cream....
do Blog: IBM Redbooks Software Blog
Setting up a cold standby Netcool Gateway (on UNIX) Blog da Comunidade
There are occasions where one needs to set up a cold standby Netcool Gateway. An attached UNIX shell script is provided with this blog that will provide this functionality. It should be reviewed by the Netcool Administrator and modified to suit the...
do Blog: Network and Service Assurance


text:
SE: K-State Sports Extra Q&A: Kyle Weldon
Every month, a new student-athlete is featured through the K-State Sports Extra Q&A. This month, K-State Sports Extra sat down with men's golf senior Kyle Weldon of Des Peres, Missouri.
The lone senior on this year's squad, Weldon is recording a 73.23 stroke average this season and has recorded two top-20 individual finishes. Weldon's best finish this year came at the Rod Myers Invitational in Durham, North Carolina, where he shot 2-under par 214 and finished in fifth place.
Here's a look at what he had to say:
Sports Extra: How long have you been playing golf and when did you realize you wanted to play collegiately?
Kyle Weldon: I've been playing competitive golf for about 13 years, since I was about 10 or 11 years old. I was a big soccer player growing up, but once I hit about seventh or eighth grade, I made the switch from soccer to golf, and that's when I decided I wanted to play golf collegiately.
SE: Do you have a round that stands out as your most memorable?
KW: I've had some good rounds, but the best round I ever had, the one that sticks out to me the most, was in 2012 when I shot a 68 in the final round of a big tournament in St. Louis to win the tournament by three shots. That was a really fun one. Then the other one that sticks out is a course record that I shot at Greenbriar Hills in St. Louis. I shot a 62 – that was a really fun one.
SE: Have you ever made a hole-in-one?
KW: I've had three! I had one in a match play event at a Missouri Amateur back in 2013 and my teammate Matt Green was caddying for me. Then I have two on the par 3 course out here (at Colbert Hills). I had one on the eighth hole and one on the ninth hole. Some people might not count those, but I do!
SE: What is the emotion like when you sink a hole-in-one?
KW: After you see it go in, it's just kind of like a flurry of emotion right away. You get really excited. Whoever you're with just kind of jumps around, you high five, then do some celebrating after.
SE: So when you're not on the course hitting hole-in-ones, what can people find you doing?
KW: Well, the past few weeks I've been doing a lot of schoolwork. As a civil engineering major, I've spent a lot of time in the library. I like spending time with my friends, my girlfriend, I like playing video games; the normal stuff college kids do.
SE: Is it hard to juggle studying engineering and being a student-athlete at the same time?
KW: Oh yeah, it's really tough, but I've had a lot of really good friends that I've met in my classes and my teachers have helped me out a lot. They've all really helped get me through it.
SE: Are you graduating in May?
KW: I am. I don't have cement plans yet, but I'm planning on turning professional. I'm going to give that a shot for a while and see where that takes me. If that doesn't work out, I have my engineering degree to fall back on and I'll find a job somewhere.
SE: How would you describe yourself as a golfer?
KW: I'd say I'm kind of gritty. I don't have the best golf swing in the world, but I still manage to get it around. I really pride myself on my short game, my chipping and putting. I work really, really hard on that.
SE: Have you enjoyed being the only senior on this year's team?
KW: It's been really fun. When I came in, I was the only freshman, so that was kind of different. At times I felt a little bit of an outcast, so now I've really tried to connect with the younger guys and be a leader. I've tried to be that role model that I didn't have when I first came in. It's been a lot of fun. I love seeing the younger guys grow, and I'm excited for the future of this team. The next two or three years they'll have some really, really good players and I think it's going to take this program to higher levels.
SE: Is this team a pretty tight-knit group?
KW: We're really close. We spend a lot of time together barbecuing, bowling, things like that. We've definitely become a lot closer this year than in past years, and it's been a lot of fun.
SE: You have a few more competitions left before the Big 12 Championship. What do you hope to get out of them?
KW: We have two tournaments before Big 12s, and they're both tournaments that I think we can win as a team. I think that's the goal, to get a team win in one of these last two or both tournaments because we haven't had a win in two years now. So that's the No. 1 goal. But for me, I want to close it out, have fun and enjoy it. I only have three college events left, and that Big 12 tournament is going to be a lot of fun. It's going to be a whirlwind of emotions, that's for sure.
SE: Finally, what is the best part about being a student-athlete here at K-State?
KW: It's cliché – everyone says it – but the family atmosphere is real. You can feel it. It's something that I didn't feel at any other place but once I got here, the people are awesome. I've really, really grown as a person here and I've loved everything about K-State.
Next up for the Wildcat men's golf team is a trip to West Point, Mississippi, where the Wildcats will compete in the Old Waverly Invitational April 4-5. Following that tournament, K-State will compete in the Hawkeye Intercollegiate in Iowa City, Iowa, before heading to the Big 12 Championship, April 29-30, at Whispering Pines Golf Club in Trinity, Texas. For more information on the K-State men's golf team, please click here.
We hope you enjoy K-State Sports Extra. We would like to hear your comments and any story ideas for future emails, so fire them our way. Contact Kelly McHugh-Stewart, or K-State Associate AD for Communications Kenny Lannou.


text:
Welcome to WordPress. This is your first post. Edit or delete it, then start blogging!
Original post by admin
Anara Gupta (born August 1986) is an Indian model who won the "Miss Jammu" beauty pageant in 2001. She has been at the center of an ongoing and widely publicized pornography and police scandal in Jammu and Kashmir since 2004.A CD with pornographic movie allegedly featuring Gupta came to light in October 2004 and was […]
Latest news reveal through internet that Sunny Leon's Lover leaked New Sex Tape of her. She is a porn star, shot to fame after coming to an Indian TV reality show BIGG BOSS Season-5. She alrady warned not to promote her porn website on the show. Matt Erickson her ex's leaked her video. she got […]
Priya is looking EXTRA hot in this recent set…. her big tits look so delicious you just want to lick them all day long. The full set shows her teasing with her pussy for a bit, then she hikes up her dress and starts masturbating her tight juicy pussy with a vibrator Click Here For […]
Welcome to WordPress. This is your first post. Edit or delete it, then start blogging!
Original post by admin
Kim Kardashian has more in common with her current beau Kanye West than she initially thought, as it has been claimed the rapper has starred in his very own intimate video.
The nearly 20-minute-long recording is believed to have been shot with an unidentified female who is a 'dead ringer' for Kim herself, RadarOnline.com reports.
Filmed in what appears to be a hotel room, the married woman reportedly confirms at the start of the tape that she's over the age of 18 and fully consenting.
She adds: 'My husband and I don't have sex anymore… that's why I'm here!'
Throughout the romp, the pair allegedly don't kiss or interact in any way apart from trying out various positions.
The man who appears to be Kanye is said to be aware he is being filmed because he not only set up the camera, but also looks directly into the device at the end of the video
Click Here For The Kanye West Sex Tape
Original post by admin
Heidi Klum is really upset over brand new topless photos that have been leaked online .The Super Model is claiming her privacy was violated .The photos show a topless Heidi on vacation in the south of France , sharing intimate moments with her bodyguard boyfriend.
Original post by admin
Prince Harry Sex Tape Leaked ! An intimate video of Prince Harry has leaked. The photos of the Bare-chested Prince partying in a Vegas jacuzzi with a slew of bikini clad woman and playing stip billiards hit the ineternet in mid august 2012.Soon after reports stating there was also a sex tape up for sale started making the rounds on the celebrity websites
It was claimed that the nude strip billiards pictures of the Prince 'could be the tip of the iceberg' after accusations more could come out about his now infamous Vegas trip.A single quote from an anonymous source says: 'Something pretty gigantic' is involved; something more serious than 'strip billiards'…We now know that Prince Harry engaged in sex with atleast one woman while in vegas…and it was caught on tape ! !Now with the release of the Prince harry Sex Tape it seems the Royal British wild child has finally bit off more than he can chew !!.
Click Here For The Prnce Harry Sex Tape
Original post by admin
Kim Kardashian big booty wwas seen walkng the beaches of hawaii this week..nuff said.
Original post by admin
Miley Cyrus chopped off her hair Sunday night, Never felt more me in my whole life," the bride-to-be wrote, after posting some shots of her sleek new pixie 'do. "LOVE my hair. feel so happy, pretty, and free."
Click Here For The Miley Cyrus Leaked Sex Tape
Original post by admin
Anderson Cooper's boyfriend Ben Maisani was caught kissing another man in a New York park. In the leaked photos In the openly gay CNN news anchor'live in partner ,Maisani is sitting on the grass in a New York park trading kisses with a dark-haired man.
Ben Maisani owns the gay bar Eastern Bloc in the East Village.
Original post by admin
A leaked photo of a shirtless Mark Zuckerberg is burning up the web right now … immediately fueling suspicions of a major Facebook privacy screw-up and rumours of homosexuality.
It's unclear when or where the pic was taken … showing the billionaire smiling topless with 2 other half naked of males.
Is Mark Gay?
Original post by admin
Kourtney Kardashian Sex Tape !.Kim Kardashian's younger sister, Kourtney Kardashian Sex Tape is available now !The reality tv show star showed off her pornstar skills in the bedroom just like just her famous sister Kim.Her hot slim body has always been captured by papparazzi photographers in bikinis and skimpy tight outfits.After the recent wedding of her sister kim ,reports starting hitting the gossip websites that a sex tape featuring Kourtney was being offered up for sale by a former ex-boyfriend
Original post by admin


text:
Most Popular
- Watch your frequency. Last week, Ezrin suggested, there is an overall uptick in the number of emails going out during the holiday season, increasing message frequency to your most active customers. By increasing messaging, you can help boost the chance of those customers making a purchase and help increase company and brand awareness.
- Make offers more visible by including them in subject lines. Mailings with percent-off or free shipping offers in the subject line perform better during the holidays, according to Experian CheetahMail research, with one caveat, Ezrin said. "If you always offer free shipping, it's not effective to have it in the subject line. But during the holidays, when so many companies have special offers, it's going to boost your open and click-through rates," she said.
- Don't outdo yourself. Nothing ticks off a customer more than seeing a better offer a week after purchasing something. For this reason, b-to-b marketers may want to consider tiered offers during the holiday season. "This helps you address different segments without giving one customer an obviously better deal," she said. This might mean giving 10% off for one spending threshold and 20% off for another, which will encourage higher spending across the board. If you can't do this, make sure your messaging is honest, she said. Don't send out an offer that says, "Best prices of the season,' unless that's actually the case. "You don't want to create a disgruntled customer," Ezrin said.
- Get personal. The holidays are an emotional time for most and, because of this, Ezrin said, personalization performs better during this period. "Now's the time to test messages from the agent or agents that manage your relationships with the customers such as salespeople or resellers," she said. This extends to offers, especially if you sell something that can be marketed using a replenishment message. "You'd want to add it right below whatever standard offer you're sending out," she said.
- Be cautious with religious mentions or images. While some retailers aren't shy about putting a decidedly nonsecular spin on messaging, b-to-b marketers should be more cautious, Ezrin said, to avoid offending or alienating people. "Retailers have more fun with [religious holidays], but I hesitate to use it in b-to-b. A better option is to say, "We're celebrating the holiday season and we'd like to extend good wishes to you.' "
- Review last year's campaign. Despite the lull between Christmas and New Year's, there are some businesses that do well with emails sent during this period, Ezrin said, suggesting marketers look at last year's website and sales metrics to help better inform this year's strategy. "You need to look at your traffic and see when people engaged with you," she said. One time to avoid, however: The first week of January, when people are playing catch-up after being out of the office, she said.
- Don't forget to thank your customers. One of the most effective holiday strategies is also the easiest to deploy, Ezrin said: the thank you. "One of the campaigns we see perform really well is the "Thank you for your business,' " she said. "It's a no-brainer for b-to-b." These types of messages—which can be simple, personalized emails that contain a few links along with genuine appreciation—typically perform two to three times higher than regular bulk email campaigns, she said. People like to know that they matter, and a simple thank you is a nice way to show them just that. "It's a great way to wrap up the year," Ezrin said.


text:
Is there a better time of year than October? The crisp air, the cozy sweaters and – of course – pumpkin-flavored everything! The rest of the year aren't we all just waiting around for the return of pumpkin spice coffees and cakes? (Or is that just me?)
When your mug isn't full of coffee, I have a delicious way to keep enjoying the the flavors of fall all day long! I want to share with you a pumpkin spice cake recipe you can make in your mug. It takes less than five minutes to make with little mess. It's a perfectly portioned individual cake to keep you cozy on a cool autumn night!
Here's how to make a Pumpkin Spice Mug Cake.
Pumpkin Spice Cake
- 1 tbsp butter
- 2 tbsp sugar
- 2 tbsp pumpkin puree
- Vanilla extract
- 1/4 cups all purpose flour
- 1/8 tsp baking powder
- pinch of salt
- pinch of ground cloves
Cinnamon Crumble Topping
- 1 tbsp butter
- 2 tbsp flour
- 1 tbsp brown sugar
- 1/4 tsp cinnamon
In a mug soften 1 tbsp of butter in microwave, about 5 seconds. You don't want it melted, just soft. Stir in 2 tbsp of sugar and mix until well incorporated. Stir in pumpkin, vanilla (just a tiny bit, we're talking drops), flour, baking powder, and pinch of salt and cloves; stirring until just combined. Use the back of your spoon to smooth it out in the bottom of the mug.
Microwave 1 tbsp of butter inside your mug for 10 seconds. Stir in 2 tbsp of sugar until mixed thoroughly. Add the pumpkin puree, a drop of vanilla extract, flour, baking powder salt and ground cloves. Stir.
In a separate bowl combine the butter, flour, brown sugar and cinnamon. Stir until the mixture becomes coarse. Sprinkle your pumpkin cake batter with this cinnamon crumble topping.
Cook in the microwave for 60 seconds. Depending on your microwave power, you may need to microwave in additional 10 second intervals to cook thoroughly. It's best enjoyed warm with an accompanying cup of Pumpkin Spice coffee!
If you'd like a new coffee mug for your mug cake creations, take a look at some of Barnie's new commemorative mugs. You can see one of our new mugs pictured above. It's bright orange like a ripe pumpkin at a pumpkin patch! We have introduced a whole selection of beautiful mugs for the holiday season. Our mugs will surely make a delightful gift for the coffee lover in your life.
Until next time,


text:
|2010-02-02, 08:45
|Link #1
Natural Born Killer
Graphic Designer
Join Date: Aug 2008
Location: Roanapur
Age: 25
Highschool of the Dead
According to the caption of Monthly Dragon Age March 2010 issue on 7 Net Shopping, manga Highschool of the Dead was announced to get an anime adaptation. The authors will resume the serialization of the manga from the issue after one-year hiatus.
A mysterious, lethal disease is on the loose worldwide, resulting in a catastrophic death rate of humanity, and the increasing rise of attacks, caused by the living dead.
In Japan, several high school students and a school nurse have banded together to escape Fujimi Private High School shortly after it was attacked by "them." The group now attempts to figure who or what was responsible for this plague, and in the meantime, attempt to survive the present apocalypse.
Director: Araki Testuro (Death Note, Kurozuka)
Series Composition: Kuroda Yousuke (Gundam 00)
Character Designer: Tanaka Masayoshi (Toradora!)
Animation Production: MADHOUSE
Source: MoonPhase
Winner of Animesuki 2010 Choice Award for Best Fanservice
Last edited by james0246; 2011-02-17 at 14:32.
|2010-02-02, 08:52
|Link #2
Part-time misanthrope
Join Date: Mar 2007
That is the best news I have heard so far in 2010!
... I just don't know where exactly they want to end? It's not like the manga had a finishing point before going on hiatus.
|2010-02-02, 08:56
|Link #4
sly cat
Join Date: Jun 2006
Location: in the club
Bumped the manga thread with this recent announcement.
Whoever handles this adaptation had better put some major effort into it. Sato's unique visual style can easily be butchered if done poorly, plus all those action scenes are going to require a good degree of animation.
As for the manga, I hope they just start ending it soon so at least the anime won't be forced to wrap things up (*coughTokkocough*).
|2010-02-02, 09:14
|Link #6
Senior Member
Join Date: Jan 2009
Location: Germany
Age: 24
Great news, I started reading it some time ago, but stopped at some point. Maybe I'll continue now that there's coming an anime adaption of it.
|action, boobs, ecchi, harem, horror, romance, seinen, shounen, zombie apocalypse
|Thread Tools


text:
Julia A. Walker
In her first book, Expressionism and Modernism in the American Theatre: Bodies,Voices, Words (Cambridge UP 2005), Julia A. Walker offered a new account of American expressionist drama, challenging the traditional critical narrative of German origins by situating it within the context of late-19th century American culture. Discussing these experimental plays in relation to new communications technologies, Walker demonstrates how they drew their formal vocabulary of disarticulated bodies, voices and words from the mute bodies gesticulating on the silent screen, the ghostly voices emanating out of phonograph horns, and the impersonality of letters stamped by machines. She argues that American expressionist playwrights drew from Delsartean theories of "expression," which sought to counter the alienating forces of technological modernity by bringing the body's verbal, vocal, and pantomimic "languages" back into perfect alignment. But, where expressive culture enthusiasts coordinated these three languages, expressionist playwrights counterpointed them in order to represent a dystopic vision of modern life. Examining expressionist plays by Eugene O'Neill, Elmer Rice, John Howard Lawson, and Sophie Treadwell, Walker shows how they gave expression not only to the alienating conditions of modernity, but also to the playwrights' own fears that these new communication technologies posed a threat to that most embodied of art forms—the theatre. In a moment when mass-produced art forms were emerging, expressionist playwrights helped effect a text/performance split that set autonomous courses for literary and theatrical modernisms.
She is currently working on a second book, Modernity & Performance: Enacting Change on the Modernizing Stage. It begins with the premise that, if the historical period of modernity is marked by unprecedented waves of experiential change, and if strategies for understanding such changes were expressed in modernist art, then temporal art forms, including—and especially—the aesthetic form of performance must have encoded such strategies in their processual form. This book thus examines five distinct styles of performance that emerged over the course of the modern period in relation to five socio-cultural developments that radically changed the lived experience of modernity. Its five chapters track compelling and often surprising relationships between the Romantic "point" style of acting and the circulation of paper money, between panoramic naturalism and the globalizing compass of the railroad, between the choreography of modernist eurhythmics and the sociometrics of the modern nation state, between the self-promotional tactics of the avant garde and commercial advertising, and between the "cool" style of psychological realism and the air-conditioning condenser. Exploring the social meanings of performance form, it demonstrates how, on a stage both literal and metaphorical, performers helped audiences adapt to the profound economic, social, political and cultural changes of a modernizing world by figuring new categories of thought, modeling new social relations, and enacting new habits of self in the very ways that bodies moved.
In a recent "Hold that Thought" podcast Julia Walker brings the actress Fanny Kemble's 1831 performance of Bianca to life in Henry Millman's play Fazio. Click the image to hear the podcast.


text:
Used Bedford for sale in Gairloch
We currently have 0 used Bedford cars available in Gairloch. With the widest range of private and trade Bedford cars available in Gairloch, you have access to the biggest choice and the best prices.
Feel free to browse our selected vehicles, further refine your search, and find your perfect car.
Latest second hand Bedford cars for sale in Gairloch
Sorry, it looks like we have no used Bedford cars available in Gairloch
However we currently have: 431,823 Used cars available nationwide


text:
Currency Displayed in
Samsung Galaxy Nexus LTE SPH-L700 Parts | Sprint Nexus LTE L700 Repair Parts
We carry a full line of Original Samsung Nexus LTE L700 Parts & Accessories in stock and ready for immediate delivery. We are also here to assist you with all your Sprint Galaxy Nexus LTE Repair needs including: Samsung SPH-L700 LCD Screen Repair, Touch Panel Digitizer Repair, Keypad Repair, Charging Port Repair and more.
On November 17, 2016 Apple finally released a statement fessing up (well …
Here at CellularDR.com, we want to take the time to clarify our conditions and …
There are several different models of the Samsung Galaxy S4. They each have …
Copyright 2017 CellularDR.com. All Rights Reserved.
All prices are in USD


text:
Shipping agent may submit sign-on application for foreign crew to replace the crew who will be signed off from vessel in Singapore.
At the entry checkpoint, the crew who is granted in–principle approval to sign-on will be assessed during immigration clearance. If he meets the prevailing entry requirements, the crew will be given a Special Pass if the vessel is not in Singapore Port Waters or a Landing Pass if the vessel is in port at the time of arrival.
Subsequently, when the vessel arrives in Singapore Port Waters and proceeds to a private shipyard, the shipping agent will need to go to either to Marina South Pier, West Coast Pier or any one of the four designated ICA Crew Clearance Offices to convert his Special Pass to a Landing Pass before the crew is permitted to join the vessel. On the other hand, if the crew passes through any of the authorised landing places, ICA will convert his Special Pass to a Landing Pass during clearance.
The sign-on crew member shall leave with the vessel when the vessel departs Singapore. The crew security bond imposed will be estreated if the crew member contravenes any of the conditions of the Landing Pass.
Last updated on 21 Jul 2014


text:
01 Sep 2013
Colombo: Sri Lanka on Sunday said it was ready to probe the allegations raised by UN human rights chief Navi Pillay that some people she met during her mission to probe alleged war crimes committed during the ethnic conflict with the Tamil Tigers had been threatened.
09 Jul 2015
New Delhi: Sri Lankan batting great Kumar Sangakkara will end his international career at the P Sara Oval next month in the second match of the three-test series against familiar foes India.
01 Nov 2014
New Delhi/Bengaluru: Bangaloreans woke up on Saturday to a new name of their iconic city – Bengaluru – as the state government issued a special gazette notification to officially change the name of Karnataka's capital alongside 11 other cities in the state, to the effect on Friday evening.
01 Nov 2014
New Delhi: India has pledged Rs five million as immediate relief for victims of landslide in Sri Lanka and is also considering medium and long-term assistance.
27 Mar 2015
Beijing: The stalemate over the USD 1.5 billion Chinese funded Colombo Port City project has ended following Sri Lankan President Maithripala Sirisena's talks with Chinese leaders, China's state-run media reported on Friday.
26 May 2015
Berne: Industrialist Yash Birla, along with two Mumbai-based individuals behind City Limousines scam, is among five Indian nationals with Swiss bank accounts whose names have been made public in Switzerland's official gazette with regard to ongoing tax probes against them in India.
21 Oct 2015
Colombo: The West Indies will look to the legendary Garfield Sobers for inspiration as they bid for an unlikely series-saving victory when they take on fellow strugglers Sri Lanka in the second Test in Colombo on Thursday.
02 Apr 2015
Colombo: India has acceded to Sri Lanka's request to evacuate stranded Sri Lankans along with Indian nationals from strife-torn Yemen, the Foreign Ministry said here.
31 Aug 2015
Colombo: Indian speedster Ishant Sharma was again involved in an altercation with some Sri Lankan players during the visiting team's second innings on the fourth day of the third cricket Test here today.
16 Jul 2014
Mumbai: Private carrier Jet Airways said that it will launch another flight to Colombo from here starting November 5, in addition to the existing one, to meet the growing traffic demand on the sector.


text:
Author | exchange4media Mumbai Bureau | Thursday, May 04,2006 7:31 AM
P&G has launched a new shampoo under its Head & Shoulders (H&S) brand called New Best-Ever Head & Shoulders with Advanced VitaZinc system. To announce the new release, P&G has unveiled a new action-packed animated commercial with Preity Zinta playing a sci-fi warrior woman.
The objective of the campaign was to communicate the effectiveness and gentleness of the new H&S shampoo. But the challenge for the ad agency Saatchi & Saatchi was to find out how to best communicate the power and beauty in a creative, action-packed manner.
After several brainstorming sessions a germ of an idea was sown by the agency on personifying the brand Head & Shoulders as a 'Warrior Woman' in order to combine the versatile attributes of power and beauty that the brand (and Zinta) embody. The reference used for the 'Warrior Woman' copy was lots of action movements, with a mixture of sci-fi action and Chinese martial arts.
This is the first time Zinta has been involved in an action-cum-animated copy for H&S. Her past commercials for H&S have been very beauty-oriented with a realistic scenario, portraying her grace and poise.
The ad was shot in Bangkok and Zinta experimented with different poses, expressions and actions, till she could get every shot right. Since the entire film was shot behind a blue screen, her challenge was to fully exploit her power of imagination to visualise what is happening around her and perform accordingly for the camera.
Sharing the perspective Anantha Nayak, Marketing Manager, P&G Beauty, said, "Zinc is no longer just a mineral renowned for its healing benefits; the supercharged New Head & Shoulders' advanced VitaZinc system has made this vital mineral into an essential beauty fix. With a new product and a new Preity Zinta campaign, we hope consumers will experience the benefits that the number one anti-dandruff shampoo in India provides, and enjoy great looking, healthy, smooth hair."
Speaking on her new on-screen action-packed role in the Head & Shoulders film, Zinta said, "Being associated with Head & Shoulders, the world's No. 1 anti-dandruff shampoo has a true delight and in my latest on-screen role my fans will see me in a new action-packed avatar where I play a powerful warrior like the New H&S with advanced VitaZinc system, which removes more dandruff in one wash than ordinary shampoos do in three washes. I urge my fans to try the new best-ever product, and get dandruff-free, beautiful hair all day, and stay head and shoulders above the rest."
Zinta's role as a sci-fi warrior in the new action-cum-animated Head & Shoulders campaign will be complemented with attractive point-of-sale materials featuring, on-air and on-the-ground promotions and a host of other marketing initiatives to educate consumers about the five signs of dandruff. Besides Zinta, Head & Shoulders has been endorsed by Hollywood star Salma Hayek, Courtney Cox of 'Friends' fame, US TV star Rina Sofres, Ajay Jadeja, and Pooja Batra, among others.
Programming HeadRadio Mango