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Journal of the American College of Cardiology
Cell Therapy Needs Rigorous Translational Studies in Large Animal Models
Author + information
- Published online November 3, 2015.
Author Information
- Roberto Bolli, MD∗ (rbolli{at}louisville.edu) and
- Shahab Ghafghazi, MD
- Institute of Molecular Cardiology, Division of Cardiology, Department of Medicine, University of Louisville, Louisville, Kentucky
- ↵∗Reprint requests and correspondence:
Dr. Roberto Bolli, Division of Cardiology, Department of Medicine, University of Louisville, 550 S. Jackson Street, ACB 3rd Floor, Louisville, Kentucky 40202.
- cardiac stem cells
- cell therapy
- congestive heart failure
- ischemic cardiomyopathy
- large animal models
- mesenchymal stem cells
Cell therapy, arguably the most exciting field of research in contemporary cardiovascular medicine, is mired in controversy and uncertainty (1,2). One of the major obstacles to progress is the paucity of rigorous translational studies, particularly studies in large animals (1). Understandably, the initial evaluation of new cell therapies is usually conducted in rodents, but what should come next? Assessing every new type of cells in humans would not be safe, practical, or cost-effective. Before moving to clinical trials, promising cell types must be evaluated in clinically relevant, large animal models.
At present, however, the majority of research dollars allocated to preclinical trials of cardiac regeneration subsidize studies in rodents; only a small minority of available grants supports translational work in large animal models that are more relevant to humans. As a result, most of the preclinical knowledge is predicated on data obtained in rodents, particularly mice. Murine models are relatively cheap and quick and lend themselves to genetic manipulations, but are they relevant to humans? Are the effects of stem/progenitor cells the same in mice and humans? The answers to these questions are unknown. Evidence that murine models are similar to the human situation is scarce; if anything, there is considerable evidence to the contrary. For example, mice and humans, separated by 65 to 100 million years of evolution, differ significantly with respect to innate and adaptive immunity (3), sarcomeric proteins (e.g., predominantly MYH7 myosin isoform in humans vs. MYH6 isoform in mice), and ion channels (e.g., mice lack IKr), not to mention the gargantuan influence of genetic backgrounds in different murine strains. Human hearts do not beat 500 to 700 times/min, and repair of human myocardial infarctions requires replacement of several grams of dead tissue, not a few milligrams. Given these enormous differences, the willingness of some investigators (as well as the lay public and media) to readily extrapolate murine data to humans is, indeed, surprising. For example, mouse studies have been glibly used as a basis for recommending that clinical trials of cell therapy be stopped, which would be irrational. Of course, murine models can be useful as screening tools and to interrogate molecular mechanisms, but one must always keep in mind that the actions of stem/progenitor cells may be completely different in humans.
Given the obvious limitations of murine models, it is crucial for the progress of the field that cell therapy be studied in large animal models that are closer to the clinical setting. In this issue of the Journal, Karantalis et al. (4) report that the combination of mesenchymal stem cells (MSCs) and c-kit+ cardiac progenitor cells (CPCs) was superior to MSCs alone in improving global left ventricular (LV) performance in a porcine model of chronic ischemic cardiomyopathy; both treatments, however, achieved a similar improvement in wall motion in the infarct zone and a similar reduction in scar size. This group had previously found that human CPCs and human MSCs have additive effects in repairing infarcted myocardium in pigs (5). Compared with that earlier study, the present research is a significant advance because of several aspects that increase the clinical relevance of the observations. First, the authors used autologous porcine cells as opposed to xenogeneic human cells, thereby obviating the need for immunosuppression, which could alter the response of the host to the transplanted cells and has no clinical correlate. Second, the cells were delivered transendocardially with the NOGA system for electroanatomic mapping (Biosense Webster, Inc., Diamond Bar, California) as opposed to the transepicardial route (6), which is not feasible or practical in most patients. Third, the cells were transplanted 3 months after myocardial infarction (MI) as opposed to 2 weeks after MI; that is, cell therapy was performed in a setting that simulates chronic ischemic cardiomyopathy rather than acute or subacute MI. An important strength of this study is that it was conducted in a well-established porcine model (7), with the use of state-of-the-art methods and a demanding protocol lasting 6 months. Taken together, the findings of Karantalis et al. (4) provide further evidence that combining MSCs with CPCs results in greater efficacy than using MSCs alone for the treatment of post-MI LV remodeling and dysfunction, even when the healing process is complete and the disease has entered its chronic phase.
The findings of Karantalis et al. (4) have clear therapeutic implications. Phase I clinical studies have suggested that both CPCs (8) and MSCs (9) alleviate LV dysfunction, reduce scar size, or both; if the results of the present study are applicable to humans, the effectiveness of cell therapy in patients with chronic ischemic heart failure would be enhanced. In conjunction with a previous study by this group (5), the observations of Karantalis et al. reinforce the rationale for the soon-to-be-initiated CONCERT-HF (Combination of Mesenchymal and C-kit+ Cardiac Stem Cells as Regenerative Therapy for Heart Failure [NCT02501811]), a Phase II trial by the Cardiovascular Cell Therapy Research Network that will compare the safety, feasibility, and efficacy of MSCs alone, CPCs alone, and their combination in patients with ischemic cardiomyopathy.
Few studies have combined 2 cell types at the experimental level (5,10–18) and none at the clinical level (Table 1). In general, these studies found that combination therapy was superior to single-cell therapy. As indicated earlier, Williams et al. (5) administered human CPCs, human MSCs, or their combination in a swine model of subacute MI. Left ventricular ejection fraction was restored to baseline with both single and combination therapy. However, the reduction in infarct size was double with combination therapy compared with single-cell therapy; in addition, the engraftment of transplanted cells was 7-fold greater with the combination therapy than with either cell type alone. Using human saphenous vein–derived pericyte progenitors (a subtype of MSCs) and CPCs in a murine model of acute MI, Avolio et al. (10) showed that both single-cell and dual-cell therapy led to an improvement in left ventricular ejection fraction and a reduction in interstitial fibrosis; however, only the combination therapy resulted in a reduction in infarct size and an increase in arteriogenesis compared with vehicle. Similarly, Winter et al. (11) reported that the combination of epicardial-derived cells and cardiomyocyte progenitor cells was superior to single-cell therapy. In yet another study, Latham et al. (12) demonstrated in a murine model of acute MI that the combination of human circulatory angiogenic cells and cardiac stem cells resulted in greater improvement in left ventricular ejection fraction, a reduction in infarct size, and an improvement in capillary density compared with single-cell therapy. The positive interaction between 2 cell types reported in these studies (5,10–18) was presumably the result of paracrine mechanisms. Taken together, the present report (1) and these previous studies (5,10–18) support the concept that combinatorial therapy is likely to be superior to single-cell therapy, and it should therefore be one of the main avenues for future research.
The work of Karantalis et al. (4) is also important because it epitomizes rigorous translational research. Translational studies in large animal models (usually pigs) are rare because they are expensive, complex, time-consuming, technically demanding, slow, and usually not suitable for mechanistic investigations; nevertheless, because they are conducted in settings closer to the human situation than those found in rodent models, these studies are essential to justify the risks and costs of clinical trials. Unfortunately, the added value of the clinical relevance of large animal models is often not appreciated by reviewers of manuscripts and grant applications, who assign low scores on the basis of lack of mechanistic insights and insufficient conceptual novelty. For cell therapy to be translated into clinical therapies, it is critical that this misperception be corrected.
It is also critical that access to large animal models be available to the entire scientific community because very few investigators have the expertise necessary to use such models successfully. While the number of molecular and cellular biologists working on stem/progenitor cells continues to increase, the number of integrative physiologists continues to decrease inexorably. These considerations provide a cogent rationale for the National Institutes of Health to establish a national consortium of core laboratories that have expertise with large animal models and make these complex models available to the scientific community. With such an infrastructure in place, all investigators would have the opportunity to conduct studies of stem/progenitor cells in relevant and rigorous preclinical models that would otherwise be impossible for them to use. Such an infrastructure would be analogous to the Consortium for Preclinical Assessment of Cardioprotective Therapies, which was developed to study reductions in infarct size (19).
A massive disproportion currently exists between rodent studies and large animal studies. There is a need to increase the number of rigorous and relevant preclinical studies, such as that by Karantalis et al. (4). Until a publicly available consortium is developed to rigorously evaluate stem/progenitor cells in clinically relevant, large animal models, the progress of cell therapy will be hindered, and translation into human therapies will be difficult.
↵∗ Editorials published in the Journal of the American College of Cardiology reflect the views of the authors and do not necessarily represent the views of JACC or the American College of Cardiology.
This work was supported in part by the National Institutes of Health grants HL-113530 and HL-78825. Both authors have reported that they have no relationships relevant to the contents of this paper to disclose.
- American College of Cardiology Foundation
- ↵
- Sanganalmath S.K.,
- Bolli R.
- Keith M.C.,
- Bolli R.
- ↵
- Mestas J.,
- Hughes C.C.
- ↵
- Karantalis V.,
- Suncion-Loescher V.Y.,
- Bagno L.,
- et al.
- ↵
- Williams A.R.,
- Hatzistergos K.E.,
- Addicott B.,
- et al.
- ↵
- Henry T.D.,
- Traverse J.H.,
- Hammon B.L.,
- et al.
- ↵
- ↵
- ↵
- Karantalis V.,
- Hare J.M.
- ↵
- Avolio E.,
- Meloni M.,
- Spencer H.L.,
- et al.
- ↵
- Winter E.M.,
- van Oorschot A.A.,
- Hogers B.,
- et al.
- ↵
- Latham N.,
- Ye B.,
- Jackson R.,
- et al.
- Ott H.C.,
- Bonaros N.,
- Marksteiner R.,
- et al.
- Bonaros N.,
- Rauf R.,
- Werner E.,
- et al.
- ↵
- Jones S.P.,
- Tang X.L.,
- Guo Y.,
- et al.


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Model dog Bracken unleashes her latest 'Sherlock' inspired look
A local pooch has paid homage to the 'Hound of the Baskervilles' by posing next to Tenby's iconic St. Catherine's Island, where the BBC's Sherlock series was recently filmed.
Looking 'fetching' in her Sherlock Bones outfit, German Shorthaired Pointer, Bracken had been sniffing out locations for her latest photo shoot, after becoming the face of Aviva Pet Insurance Online.
Owner Alison Rees who lives near Tenby and also runs the 'Dog Friendly Pembrokeshire' Facebook page said she wanted to do something a 'bit different and fun' for Bracken's most recent venture into the modelling world.
"St Catherine's Island is photographed a lot so I had to think outside the box. Bracken is trained and using the 'hold' command I was able to teach her to hold the pipe and Sherlock Bones was born! She takes it all in her stride.
"The people that saw us doing the shoot loved her. Watch this space for her next shoot! " added Alison.
You can follow Bracken's modelling career on the Twitter account @BrackenDogModel

subset: commoncrawl


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Status 500 for non-admins
When a user that is not an administrator tries to log in, the response is status 500 server error.
Also tried User Switching with the same fatal result trying to switch.
I have turned off a lot of security features provided by this plugin just to see if I can track down what causes this, with no luck.
I would believe that this plugin would never triggers a status 500 deliberately, but uses some other status to deny the request.
Deactivating the plugin immediately restores proper login for my editors and contributors.
Server runs PHP 5.3.3 with FastCGI on Apache
- The topic 'Status 500 for non-admins' is closed to new replies.


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Tennant Creek woman wins mum of year award
A 25-year-old woman from Tennant Creek in the Northern Territory has been named Barnardos Australia's Mother of the Year.
Rebecca Healy lives in Tennant Creek where she looks after her three and four-year-old sons, supports her 16-year-old sister and is an emergency foster parent.
The single mother says she left home at 12 and only got to Year 8 at school.
She was taken in by the Tennant Creek Refuge when she was 18.
Ms Healy says the women running the refuge helped her turn her life around and now she can do the same for other children in need.
"Every child needs a safe place, they really do," she said.
"If I am able to give that to them at any time of the day or night then that is what I will do.
"Hopefully more young mums will come on board now to do the same thing."
Ms Healy works as an Indigenous economic development officer and started the Barkly Youth Services Providers Network.
Barnardos cares for thousands of children.
The Barnardos Australia's Mother of the Year Awards aim to show what an important role mums play in giving kids a good start in life.
The other aim of the award is to raise public awareness of the nurturing role Barnardos plays in many children's lives.
As one of Australia's largest children's charities Barnardos has parental responsibility for abused and neglected children placed in their care each year.
Topics: family-and-children, charities-and-community-organisations, welfare, awards-and-prizes, tennant-creek-0860, australia, nt


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On this page:
Definition of the noun Alydus
What does Alydus mean as a name of something?
Alydus is a genus of Alydidae, described by Fabricius in 1803.
- synonyms: genus Alydus / Coriscus / genus Coriscus
- kingdom: Animalia
- phylum: Arthropoda
- class: Insecta
- order: Hemiptera
- family: Alydidae
- members:
- species Alydus angulatus
- species Alydus calcaratus
- species Alydus conspersus
- species Alydus eurinus
- species Alydus pilosulus
- species Alydus pristinus
- species Alydus pulchellus
- species Alydus rupestris
- species Alydus scutellatus
- species Alydus tomentosus
- species Alydus zichyi
- observational distribution: specimen and observational data from the Global Biodiversity Information Facility Network (not necessarily true occurrence density gradients)
Count per one degree cell 1 - 9 10 - 99 100 - 999 1000 - 9999 10000 - 99999 100000+
Alydus is a genus of Alydidae.
- kingdom: Metazoa
- phylum: Arthropoda
- class: Insecta
- order: Hemiptera
- family: Alydidae
Phrases with Alydus
- Alydus pluto
- Alydus Scaber
- Alydus Zichyi
- Alydus Apterus
- Alydus eurinus
- Alydus apicalis
- Alydus Clavatus
- Alydus curtulus
- Alydus dentatus
- Alydus limbatus
- Alydus Robustus
- Alydus Angulatus
- Alydus pilosulus
- Alydus Rupestris
- Alydus calcaratus
- Alydus conspersus
- Alydus Ornaticeps
- Alydus tomentosus
- Alydus Abdominalis
- genus Alydus
View more phrases with the word Alydus in thesaurus!
Printed dictionaries and other books with definitions for Alydus
Click on a title to look inside that book (if available):
Encyclopedia of Entomology (2008)
by John L. Capinera
top right, a broad-headed bug, Alydus pilosulus (Alydidae); second row left, a largid bug, Largus succinctus ...
The Encyclopaedia Britannica (1855)
Or, Dictionary of Arts, Sciences, and General Literature
already mentioned, and the genus ALYDUs of Fab. includes ...
The Century Dictionary (1889)
An Encyclopedic Lexicon of the English Language by William Dwight Whitney
( Alydus + mice] A subfamily of Coreidw. t ified by the genus Al dull, containing insectso moderately narrow em, with a somewhat conical head contracted behind the eyes, the last antenna! 1011115 enlarged, and the hind femora spiuous ...
Online dictionaries and encyclopedias with entries for Alydus
Click on a label to prioritize search results according to that topic:
Photos about Alydus
Click on an item to view that photo:
Alydus calcaratus
Photo credit: jmdb21650
View more pictures about Alydus eurinus.
If you need related images for an article or a report, you can download stock photos:
Scrabble value of A1L1Y4D2U1S1
The value of this 6-letter word is 10 points, but it's not an accepted word in the Official Scrabble Players Dictionary.
Anagrams of ALYDUS
What do you get if you rearrange the letters?
See also the blanagrams of Alydus!
Share this page
Go to the thesaurus of Alydus to find many related words and phrases!


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March 14, 2012
Linsalata Capital Partners has promoted Timothy G. Healy to senior vice president. Mr. Healy joined the firm in 2004 and now leads its marketing, intermediary development activities and deal sourcing efforts. He also serves on the oversight team for The Tranzonic Companies. Prior to joining LinCap, Mr. Healy spent 13 years with National City Bank, where he rose to the position of senior vice president in the Equity Sponsor Group.
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Two employees of Minority Welfare Department MWD who were serving in Andhra Pradesh have been allotted for Telangana. Both the employees will now serve for Telangana Minority Welfare Department.
Secretary Minority Welfare Syed Omer Jaleel issued orders in this connection. During the process of distribution of staff under Andhra Pradesh Reorganisation Act, services of M A Aziz record Assistant Minority Welfare Department Andhra Pradesh and S Jagan Office Subordinate Minority Commission have been allotted to Telangana and they are directed to join duty. Telangana Minority Welfare has permitted them to retain on the same posts in Telangana Minority Welfare Department.
Siasat news


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Once I've identified a book I want in the catalog and know its call number, how do I know where to find it in the library?
Last Updated: May 15, 2015 | 96 Views
Topics: About the Libraries
Was this helpful? 0 0
Click the "location" (often Pius Library) shown in the catalog for the book you want. That will link you to the current location guide, which indicates which materials and call number ranges you can find on each floor. Printed location guides are also available at the service desks on the first floor, and near the catalog computer terminals elsewhere in the building.
When in doubt, feel free to ask any library employee to help you!


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It's not a regular occurrence that you discover you need a replacement Window Motor, Power to fix your automobile. While it may not be difficult to buy replacement parts for Chevrolet vehicles, these days the necessity for nothing but the absolute best are required to fix your automobile. Make no mistake, you bought your C10 because you understood you would be getting horsepower and good looks both rolled up into one car, truck, or SUV. Chevrolet automobile drivers have come to expect a certain level of reliability when driving their C10 around town.
In order to get full functionality out of your car, you have to be able to raise and lower your windows. If you have power windows, it would be your power window motor that does the job of moving the glass up and down. Your Chevrolet C10 power window motor is responsible for actuating the main pulley on your regulator; pulling the cable in one direction or another as the window glass rises and falls. It's easy to take the window motor on your car or truck for granted when it's working, but easy to see how much you've come to rely on it when you can no longer use it. Don't be the person who drives your Chevrolet C10 with the windows down in the rain because your power window motor doesn't work.
Given all the trouble that can be involved with installing a part to fix your car or truck, let www.carpartsdiscount.com be the most authoritative website you go to make buying it easy. When your Chevrolet needs the best replacement Window Motor, Power, there's no need to waste time looking anywhere other than the authority, Car Parts Discount. Buy all the car parts you will ever need from carpartsdiscount.com and save time and money on all your upcoming repairs. Need 1986, 1985, 1984, 1983, 1982, 1981, 1980, 1979, 1978, 1977 Chevrolet C10 Window Motor, Power parts? We've got them right here.


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Tomorrow is going to be 67 degrees with humidity of 53% but also 22mph. IS this cold or hot? am i going to be hot with boots a scarf and flannel?
No guys shared opinions.
That's not hot or cold. I wouldn't wear boots and scarf and flannel during that weather.
You could get away with boots but its not cold
at least here in Australia 40 degrees Celsius is hot which I think equals 104 Fahrenheit
That's beach weather. Srsly I'd be chillin in my hammock.
You cannot undo this action. The opinion owner is going to be notified and earn 7 XPER points.


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I was so glad to do a local Art Show and Book Signing Event this past Saturday! Had a wonderful time and met some very sweet people! It has been awhile since I've posted, but this is some of what I've been up to!
Inspiring One Dreamer at a Time!
Tag Archives: artist
This of course is not my photo, but someone posted it on my facebook timeline and It suited me!
Christine's Art Gallery
Just a small sampling of some of my Art that I've enjoyed painting! I can replicate many of them if interested.


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Made in Canada Lacrosse leather gloves by WinnWell model L77. The gloves are in excellent condition. Very little wear. No splits or holes, no inked owner's name. Nice butterscotch color with black knuckle details. Hinged cuffs. Oil cloth trim. 12" (35 cm). FREE SHIPPING
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To view other FINE SPORTING ITEMS I have listed please type SPORTS in the SEARCH above.
Canadians will pay applicable taxes.
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In business since 1984 we specialize in Majolica, Oyster Plates, Sports items & Trophies, 19th C Photography + more


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I Made The Wrong Size Cake.....help!!!
Decorating By Crystal74 Updated 27 Aug 2008 , 6:03am by KoryAK
I have a wedding cake order due for Friday. Square cake to feed 100. I went to take the cakes out of the freezer tonight. Low and behold, I made 2-14" cakes, 2-6" cakes, and 2-8" cakes. The 8" ones should have been 10" !!!!!!!!
Would a 14,8,6 combination look really bad? I still have time to make the 10's tomorrow, but I just wanted to get your opinions.
I think it's going to be too big of a jump from the 8 to the 14 to look good. I suppose you could make it work, but I would bake the 10's myself.
Oh, this happened on my last wedding cake I did. I was debating on a 12" or 10" for a long time. So, I made the 10" and once it was all decorated and getting the cake plates out, I found out I should have made the 12. I rebaked.
Good luck...and remember to breath!
I agree, bake the tens. it would look out of proportion with the size differences.
make the 10s.
make em. sorry.
I agree make the 10's= to much of a jump to 14- sorry
I agree make the 10's= to much of a jump to 14- sorry
You can, however, cut one of the 10" layers to piece together with the other to make one 14"
layer (if you can) so you only have to rebake one. Thats what I wouls do.
10's are my vote too!
Maybe you subconsciously made the 10s because you know that 6-8-10 x 4" IS 100 servings. Boy you sure are givin' away the farm on this one!


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So you may be wondering how I am finding these projects to highlight. The answer is you! Yes, most of my posts come from the projects my friends back as well as ones shared with me through connections. It does not mean I will write about each of them. The chances are high because my friends are an incredible collection of innovative folks themselves. I also will be highlighting projects some of them hopefully will start. Probably the least favorite method is scanning the latest projects. Why is this my least favorite? For the most part the projects are boring and lifeless. But then again that is why I started Flurry's Pick, so you wouldn't have to look far for your next investment.
So today's pick is one backed by my good friends Justin and Jon of Catalytix. Innovative wallets are something I love. My personal favorite is the ID Wallet by Saddleback. I think it will be the last wallet I will ever buy. The Wood Wallet by I Want Proof is both innovative and fun.
Find out more about the Wood Wallet on their Kickstarter page


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Luiz Felipe Scolari's only bad memory of Chelsea was the cold, the Brazil coach said on Sunday as he returned to a frigid Stamford Bridge for the first time since being unceremoniously sacked in 2009.
"I'm happy to be here again, it's a place where I enjoyed working," said the man known as Felipao (Big Phil), whose side face Russia in a friendly on Monday.
"The only think I didn't like was the cold, I'm not used to it any more."
"It's bad," he added after shivering his way through a training session in freezing conditions with a biting wind.
"The players couldn't feel their fingers or their toes. It's tough, it's bad for playing in. I think we're going to suffer more than our opponents."
Scolari, who led Brazil to their fifth World Cup title in 2002, lasted only seven months at Chelsea before being dismissed.
"It wasn't as bad as people think," he said. "We were third in the league, we were still in the FA Cup and the Champions League, so I don't know.
"I can't say that I would have won anything if I'd stayed and I can't say I would have not won anything."


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Midnight Oil - Gravelrash MP3
Midnight Oil - Gravelrash.
Gravel Rash - Immolateding MP3
After our 2nd place victory at Alton Community Centres' Lounge Bar Battle of the Bands 2012, we won a free music video shoot. We were contacted by Hana ...
Opiuo - Gravel Rash MP3
Opiuo's Butternut Slap 3 EP is here! Check out the EP: http://www.addictech.com/p/112480.
Gravelrash Do It Again MP3
Our first video - music by Gravelrash, video by Clinton McRobert.
Gravel rash! MP3
Gravel rash!
Opiuo - Gravel Rash MP3
Available to buy here: http://bit.ly/QGAXx5 ○ Subscribe for more music: http://bit.ly/subscribetoghc ○ Get free wallpapers: http://bit.ly/getfreeghcwallpapers ...
GRAVEL RASH AT LA GRAVIERE Quiksilver Pro France 2012 MP3
http://www.100percentsurf.com.au/MAGAZINE/MAGAZINE/VIDEO_HOME.html Music by 100percentelectric ...
Cleaning up the Road Rash MP3
Cleaning up the Road Rash.
09 Cookin' on 3 Burners - Gravel Rash [Freestyle Records] MP3
Download: http://shop.kudosrecords.co/FSRCD026 Subscribe: http://ytsub.kudosrecords.co/FreestyleRecordsLtd Official stream from Freestyle Records.
Gravelrash MP3
Provided to YouTube by Sony Music Entertainment Gravelrash · Midnight Oil / 午夜石油合唱團 Breathe ℗ 1996 Sony Music Entertainment (Australia) Limited ...
Loose Gravel - Gravel Rash - 1977 MP3
Mike Wilhelm! Dutch label Dynamite 7" from 1977, track recorded somewhen between 1972 and 1976.
Midnight Oil ,Gravelrash ,cover MP3
A cover from the 1996 Album "Breathe".An Almost follow up Surf Tune to Wedding Cake Island!I wonder If The Break do a cover of this Tune!I Hope so ,And I ...
Gravelrash - Do It Again Live 16 Jan 2015 MP3
Gravelrash live at The Basement in Canberra, at the launch of our new album 'Meant To Be'.
Gravel Rash - Cookin' On 3 Burners live @ The Basement Sydney MP3
Gravel Rash - Cookin' On 3 Burners live @ The Basement Sydney, Australia.
Gravelrash MP3
Gravel Rash MP3
Provided to YouTube by The Orchard Enterprises Gravel Rash · Offcutts Thrift Shop Boutique ℗ 2004 Rubber Music Pty Ltd Released on: 2006-06-25 ...
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jammin 'Gravel Rash' with Cookin' on 3 Burners at 303, Northcote, Melbourne in 2011, Jake Mason on Keys, Ivan Katchoyan on drums.
2015 S1000RR - GoPro Gravel Rash - Chase Cam - Abusing Nature MP3
Public Holiday exploited with a quick ride through Mt Lindesay No audio of me in this vid, instead its all BMW doing the talking.
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My Fiction kicking out a swifty version of their tune Gravel Rash at x&y Bar in Brisbane. Lovin' it!
Japanese Gravel Rash!! MP3
Check out our playlists for hundreds more Japan videos!
Martin Carlo vs Gravel Rash MP3
2012 Toowoomba Show Rodeo 2nd on 81 points.
Gravel Rash MP3
Provided to YouTube by Ingrooves Gravel Rash · Opiuo Butternut Slap Pt. 3 EP ℗ Addictech Records Released on: 2012-10-22 Writer: Opiuo Auto-generated by ...
manic man by gravelrash MP3
mr bush you make me this way,if you like this song and vid or dont like it let me know all feedback gratefully recieved,the music and video were made in my attic,, ...
Gravel Rash - Ride It Like You Robbed It (Music Video) MP3
Gravel Rash - Ride It Like You Robbed It (Music Video). Filmed on an iphone 4S and edited on imovie. All stunts and awesome stuff undertaken by Gravel Rash ...
Gravel Rash MP3
Provided to YouTube by KudosRecords Gravel Rash · Cookin' on 3 Burners Baked, Broiled and Fried ℗ Freestyle Records Ltd Released on: 2007-10-01 Main ...
Gravel Rash - Sleeping with the Fishes MP3
Gravel Rash live at The Lanyard in North End Portsmouth.


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BEIJING–Marleen Veldhuis anchored the Netherlands to women's 4x100 metres freestyle relay gold on Sunday to secure her country's first Olympic title in the event in 72 years.
Dara Torres, who became the first U.S. swimmer to compete in five Olympics as well as the oldest at 41, followed Veldhuis home for the silver while world champions Australia finished third.
Torres, who now has 10 Olympic medals, was already the oldest swimmer to win a medal. She won her first in 1984 before team mate Michael Phelps, who won his ninth medal earlier, was born.
The Dutch quartet, whose Olympic record time of 3:33.76 was only just outside the world mark of 3:33.62 they set in March, were chasing their country's first gold in the event since the 1936 Berlin Games.
In the end, they won by a body length.
"Of course we went in the race as world record holders but we knew that especially America and Australia would be fast and strong," said Veldhuis. "So we just went in to explode in the water and see what results we get."
The Dutch were only seventh after the first leg of 54.37 swum by Inge Dekker, with Germany's former world record holder Britta Steffen nearly a second quicker in first place, but Ranomi Kromowidjojo moved them up to second.
Femke Heemskerk then took the lead before handing over to Veldhuis for the final touch.
World champions Australia, with current world record holder Libby Trickett returning after missing the heats, took the bronze after fighting back from teenager Cate Campbell's last place at the first handover and seventh at the halfway stage.
Trickett's final split of 52.34 was the fastest of the race.
"It was great, we're really happy with our performance, we came up with an Australian record," she said.
"Third is nothing to be sneezed at, I'm proud to be part of this team and get on the podium again.
"The Dutch were fantastic, they're great, they deserved that."


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New Windows Era It's strategy time for Microsoft customers as Windows Vista goes into beta testing. So, what's your plan?
Mozilla Goes Mobile Mobile-phone version of the popular Firefox browser is previewed for developers.
General Motors Signs Biggest Java Deal Ever For Sun, the GM deal and another with General Electric are signs of a rebound
Microsoft Denies IE 7 Breaks Yahoo, Google Toolbars Company says problem was a bug in pre-beta versions that's fixed in Beta 1 version released last week; denies rumors that MSN search engine will be only default search in IE and pledges to support third-party toolbars and search engines. Internet Explorer.
Feds To Offer Low-Cost Health-Care Software But it might not be enough to spur physician adoption of E-health-record technology.
Under New Management One year after assuming the CEO job at Informatica, Sohaib Abbasi assesses where the company and the data-integration market are going.
National City Banks On TransUnion Cross-Selling System Software analyzes criteria such as estimated income and debt-to-income ratios to help the bank decide whom to extend credit-card offers to.
More Options: Wireless Messaging Gets Flexible With wireless instant messaging, devices are used to access business IM systems as well as popular services such as AOL Instant Messaging, MSN Messenger, and Yahoo Messaging.
Order From Chaos Via RSS Businesses are taking a cue from bloggers with a new way of distributing information. The appeal: It's really simple.
Getting Started: Several Ways To Use RSS Try out two or three different readers. Some excel in certain areas--and they all have their quirks.
SmartAdvice: Use Java And WebSphere To Reengineer Legacy Mainframes Set guidelines that ensure easy technology transitions and migrations, The Advisory Council says. Also, to profit from RFID, rethink business rules.
Business Objects Reports 18% Second-Quarter Sales Increase Growth fueled by BusinessObjects XI sales and more million-dollar contracts
The New Sell-Side Trader Brokers are morphing into execution consultants to advise the buy side on selecting algorithms and measuring performance.
Microsoft Investigates Reported Hack of Windows Authenticity Check A popular blog reports that Microsoft's online validation process for Windows has been hacked.
Microsoft's Growth Strategy Includes Premium-Priced Windows And Office Versions The company's new triumvirate -- Gates, Ballmer, Ozzie -- lays out a growth strategy that also includes making more acquisitions to enter new markets, and selling more services
Dashboarding From The Bottom Up A heck of a lot of organizations are rolling out reporting and analytics capabilities to their so-called "line-of-business" workers -- those knowledge employees whose ability to make smart decisions impacts things on the operational level. In other words, the people who really make a business run. As dashboards spread to more and more folks throughout the organization, one prominent business performance management executive has some advice for companies taking on new dashboard deployments: St
Government Agency To Offer Low-Cost Electronic Health-Record Software But convincing doctors to adopt the software and change the way they do business will be a challenge.
Revealing E-Mail's Secrets Tool lets analysts create a picture of communicators and can be used to fight terrorists and help businesses
Analysis Tool Cuts Bottler's Costs Sales-performance and trade-promotion software helps Pepsi Bottling Ventures track sales, plot deliveries, and deliver new products faster.
Uncover Patterns In Processes Complex-event processing consists of monitoring the whole set of events that make up a business process and can help companies comply with regulations
Cognos Brings New Market and Product Strategy to Market Cognos Version 8 and Cognos Office Connection highlighted at Cognos Forum 2005.
RFID Innovator Gets $66 Million Funding The funding bring Alien's total capital investment to $200 million.
Microsoft's Get-Out-Of-Jail Card Longhorn, a difficult-to-herd animal of the Nor'West, has been roped, corralled and rebranded as Vista.
Cognos Offers a Sneak Peek at Version 8 September BI suite release tightens integration and unifies UI.
IBM Takes on Information Integration Initial vision combines adjacent products as starting point.
SAP Purchase of Lighthammer Likely to Deliver Performance Solutions Acquisition targets SAP's 12,000 manufacturing customers.
Dell Seeks To Migrate Exchange Users Dell on Thursday debuted a turnkey package of hardware, software, and services for enterprises that want to leave Microsoft Exchange Server 5.5 before the aging mail server exits support at the end of the year.
Customer Data Challenge Consumer-goods companies have to learn to work closely with China's traditional wholesale/agent channels if they want to reap the rewards of better understanding their customers.
Dashboarding From The Bottom Up If you're rolling out new reporting capabilities, think about empowering line-of-business workers first, before taking dashboards into the executive suite.
Tibco Offers RFID Middleware RFID Interchange integrates data collected from RFID devices into business processes.
Microsoft Releases Limited Beta Of IE7 For Windows XP The tabbed-browser beta went out to 10,000 testers already lined up for Windows Vista Beta 1, as well as 500,000 members of Microsoft's TechNet and MSDN programs.
Sun Inks Largest Java Deal Ever With GM GM will use Sun Java Enterprise System to build a companywide services-oriented architecture.
Choice Hotels Rolls Out Web Analytics The hospitality industry franchisor increases online market share by applying business intelligence to its hotel brands' Web-based promotional efforts.
Windows Vista Beta Arrives Microsoft has to prove that Vista's visual polish can make PCs easier to use and close a perceived elegance gap with Apple Computer's Mac OS X.
New CEO, Same Earnings Woes For Siebel CEO George Shaheen said the company is paying for its habit of allowing too many deals to slide to the end of the quarter. "Sometimes we land the plane too close to the end of the runway."
New 'On-Demand' Offering To Help Hospitals Identify Supply Savings Medical supplies make up 25% to 30% of hospital expenses. The Neoforma system spots overcharges and inefficient purchasing.
Your Favorite Databases Readers show a wide range of views when it comes to which databases are the most analytics-friendly.
First Windows Vista Beta Could Ship Wednesday The company is holding a meeting for financial analysts on Thursday, and Microsoft watchers speculate that the company wants to kick off the meeting with good news.
Analysis: DITA Cuts the Cost of Content Reuse Switching to XML-based management for multichannel content reuse brings long-term savings, but in the short term it can be an expensive and time-consuming journey.
In Focus: What's Hot and Not-So-Hot in ECM The quarterly sport of watching vendor financial results isn't just for industry insiders. These reports are a window into not only what fellow technology users are buying but also the vision and management acumen of current and prospective technology suppliers.
BI Bullet Points Want quick advice on the best ways to leverage business intelligence tools? Check out this list.
Want A Microsoft Download? First, Complete This Test As part of Microsoft's efforts to stop software piracy, users must now install counterfeit-detection software on their PCs.
BI Bullet Points There's nothing better than a nice business intelligence bullet list. OK, maybe that's an overstatement. But they're nice. And in case you haven't seen it yet, I've got one for you.
Making Deals, Raising Cash There was a lot of money sloshing around the IT industry last week, with several companies making acquisitions and several others lining up new financing. The buyers were plugging holes in their product portfolios or buying technology. News Corp. bought more than 30 Web sites. Business Objects went for financial-planning and performance-management software. Microsoft grabbed an E-mail-services hosting company. And Broadcom focused on 10 Gigabit Ethernet technology. Meanwhile, venture capital flo
EMC Unveils New High-End Storage Array Symmetrix DMX-3 can support as much as a petabyte of data and offers information life-cycle-management capabilities.
Sun Adds Two Millionth Solaris 10 License About 11,000 operating system licenses are being distributed every day.
Hyperion Earnings Jump 40 Percent The business intelligence software maker reported earnings of $20.7 million in its fourth fiscal quarter ended June 30, compared with net income of $14.7 million in the same period last year.


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- Home
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- Kids Summer Reading Prizes
Create an Account - Increase your productivity, customize your experience, and engage in information you care about.
These prizes have already been selected! Thank you to everyone who participates in this year's summer reading program.


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FendiRed and Black Fendi Patent Leather Woven Top Handle Perforated "Bag De Jour" Tote Bag
Bold statement bag to carry your daily essentials in style. Handcrafted in Italy. Smooth leather construction with a glossy patent leather finish. Silver toned hardware. Perforated throughout. 'FF' logo and scalloped laser cut trimmings. Front logo. Top woven knit handles. Patch pockets at sides; attached woven loops with leather contrast. Top hook and eye closure. Top interior snap button closure. Open, suede lined interior features one zipper pocket. Serial:2362-8BN158-XYE-088
Made in: Italy Color: Red and Black Fabric Content: Leather. Interior: Suede. Condition: Pre-owned. This item is in good condition.Very faint scent inside interior due to storage and nature of fabric. Slight fuzziness and wear on handles. A few light marks on patent leather on exterior and interior, particularly at bottom due to nature of fabric; some may come out with wipe cleaning. Some light particles on interior due to general use; will most likely come out with cleaning. No other visible signs of wear and tear.
Measurements & Sizing
- Total Height: 13.75"
- Total Length:19.25"
- Depth: 7.25"
- Handle Length: 18.5"
- Handle Drop: 7.75"
Returns & Shipping
Luxury Garage Sale guarantees that all items sold on our site are 100% authentic. All products we accept are inspected for brand-specific guidelines and are put through a rigorous authenticity test process.
LGS is not affiliated with Fendi. We guarantee this Fendi item to be authentic. Fendi® is a registered trademark of Fendi.
Item #: 130957


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One of the most pressing issues we have faced during Obama's presidency has been the debt ceiling. Will it be raised again? If so, how will our taxes be affected? Will the government ever stop spending ridiculous amounts of money? Well it's not quite as simple as you may think – or is it?. Here's a clip that will explain exactly how the debt limit works and why we can't seem to stop raising it.
H/T: Tell Me Now


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There are bright spots, however, such as the Downtown submarket, where local companies like Roundy and Manpower are moving in from the suburbs
(Colby Abbot Building, Downtown, top right photo. 735 Water office building, middle left)
"While investment activity may moderate further through the second half of the year, buyers with market knowledge will likely continue to target assets with repositioning or value-add opportunities, particularly in the suburbs," says Matthew Fitzgerald, regional manager of the Milwaukee office of Marcus & Millichap.
Following are some of the most significant aspects of the Milwaukee Office Research Report:
· Developers are on pace to add 900,000 square feet of office space to the Milwaukee metro this year for a 3 percent stock increase.
· Vacancy is forecast to end the year at 15.8 percent.
· Asking rents are expected to gain 0.4 percent to $19.08 per square foot.
· Effective rents will end the year at $15.24 per square foot.
· The median price has appreciated roughly 15 percent to $111 per square foot during the past year.
For a copy of the complete Milwaukee Office Research Report, as well as reports on other markets nationwide, visit our website at http://www.marcusmillichap.com/
Press Contact: Stacey Corso
Communications Department
(925) 953-1716
Communications Department
(925) 953-1716


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HSCL Recruitment 2015
Hindustan Steelworks Construction Limited has depicted a job notification titled as HSCL Recruitment 2015 for filling up the Finance Officer, Senior Finance Officer, Site Engineer & other Posts. Desirous and interested candidates who want to get job in HSCL may apply online by filling the application form on or before the closing date, 28th March 2015.
Other details regarding HSCL Recruitment 2015 such as vacancy details, age limit, qualification requirement, pay scale, mode of selection, how to apply are tuned here on this page written by the team of bharatrecruitment.com.
Name of Posts:
- Finance Officer
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- Finance Manager
- Site Engineer
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- Sr. Project Engineer / Project Engineer
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Education Criteria:
Applicants must have I.C.W.A. / C.A. / I.C.W.A. (Inter.) / C.A. (Inter)/ B.E. / B.Tech (Civil) Degree according to the post from well recognized university/ Institute.
Pay Scale:
Contenders will get the impressive amount of salary that will be decided by the management on the basis of their qualification and experiences.
Mode of Selection:
The selection of the aspirants will be made on the basis of their performance in interview.
Interview Tips For Freshers / Exp.
How to Apply for HSCL Recruitment 2015?
- Willing aspirants can apply online mode only.
- First candidates need to go to the official website of HSCL that is www.hscl.co.in
- Choose the "HRD, CSR" option and select "Career with HSCL" tab.
- Select the link of the post you want to apply for.
- Now application form will be displayed on your computer screen.
- Fill the form correctly with all the necessary information & upload the required testimonials (if required).
- At last check the application form at once & press "Submit" button.
- Take the print out of it for future reference.
Steps To Fill Online Application Form
Important date:
Last Date for Online Applications: 28th March 2015
Aspirants may check Official Link for more details regarding HSCL Recruitment 2015.
You may also like to visit this Section


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The band turned out for its first gig of the new term on Sunday September 8th, entertaining visitors to the 14th Norland Scarecrow Festival. Despite a bad forecast, the sun came out, making it possible to play all three sessions outside rather than in the church hall, as was the case last year.
The gig was the first for band members since the summer break - and on return from the highly successful Paris Band Tour. More details and pics to follow on this shortly!
The next get together is on Thursday, September 19th at 6.30 in the band room when there will be a chance to hear the "Paris Collection" and also to view the wonderful photos taken by Alvaro Gonzalez which will shortly be available to buy.
We have been asked to play for an hour or so in Calder Holmes Park 3-4 pm on Saturday September 21 and don't forget its our Annual General Meeting, again in the band room, on Thursday October 3rd, when we will be badgering parents to consider joining the committee and/or offer help at rehearsals and events.
The committee next meets on Monday October 7th at Sue Holmes' house.
And another date for the diary - Autumn Fair on Saturday October 19th. So please spread the word!


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Home > Wellness > Health Library > Implantable cardioverter-defibrillator (ICD)
Browse and register for related classes.
doctor places an implantable cardioverter-defibrillator (also called an ICD) in
the chest. The ICD has one or two wires called leads that connect to the heart
through the subclavian vein. The ICD checks the heartbeat for an abnormal rhythm. If the ICD
senses an abnormal heart rhythm, it sends out either electrical pulses or a
shock to fix it.
ByHealthwise StaffPrimary Medical ReviewerRakesh K. Pai, MD, FACC - Cardiology, ElectrophysiologyAdam Husney, MD - Family MedicineSpecialist Medical ReviewerStephen Fort, MD, MRCP, FRCPC - Interventional CardiologyMartin J. Gabica, MD - Family Medicine
Current as ofJanuary 27, 2016
Current as of:
January 27, 2016
Healthwise Staff
Medical Review:
Rakesh K. Pai, MD, FACC - Cardiology, Electrophysiology & Adam Husney, MD - Family Medicine & Stephen Fort, MD, MRCP, FRCPC - Interventional Cardiology & Martin J. Gabica, MD - Family Medicine
This information does not replace the advice of a doctor. Healthwise, Incorporated, disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use. Learn how we develop our content.
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Subscribe to Filmibeat Telugu
dil raju, raviteja, bengal tiger, venu sriram, tollywood, రవితేజ, బెంగాళ్ టైగర్, వేణు శ్రీరామ్, టాలీవుడ్, దిల్ రాజు
English summary
Director Venu Sriram of Oh My Friend fame is in talks with actor Ravi Teja for a yet-untitled Telugu project that is expected to go on the floors next year. "Venu is currently busy giving final touches to the script. Ravi gave his consent after listening to a few lines of the story. If all goes as planned, the project may happen next year," a source from the film's unit revealed. The film will be produced by Dil Raju, who had also bankrolled Sriram's directorial debut Oh My Friend.
Story first published: Tuesday, September 8, 2015, 12:06 [IST]
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Vortex Crossfire II 6-18x44 AO Scope
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Product Description
Vortex Crossfire II 6-18x44 AO ScopeStyle: 875874-CF2-31033
With long eye relief, a fast-focus eyepiece, fully multi-coated lenses and resettable MOA turrets, there's no compromising on the Crossfire II. Clear, tough and bright, this riflescope hands other value-priced riflescopes their hat. The hard anodized single-piece aircraft-grade aluminum tube is nitrogen purged and o-ring sealed for waterproof/fogproof performance.
- Magnification:6-18 x
- Objective Lens Diameter:44 mm
- Eye Relief:3.7 inches
- Field of View:15.2-5.3 feet/100 yards
- Tube Size:1 inch
- Turret Style:Capped
- Adjustment Graduation:1/4 MOA
- Travel per Rotation:15 MOA
- Max Elevation Adjustment:50 MOA
- Max Windage Adjustment:50 MOA
- Parallax Setting:10 yards to Infinity
- Length:13.5 inches
- Weight:19.6 ounces


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Product Overview↑ Back to Top
Package Overview ↑ Back to Top
Samsung - 27.8 CuFt French Door Refrigerator
The Samsung RF28JBEDBSG 27.8 CuFt French Door Food Showcase refrigerator provides easy access to on-the-go items. The exterior showcase gives you instant access to drinks and condiments, while the InnerCase lets you store large, fresh food items. Perfect for frequently used items, this refrigerator lets you easily organize your food by type or family member. Metal Cooling locks in cold and seals in freshness. The stainless steel paneling helps maintain consistent temperature throughout the refrigerator.
The Counter-Height FlexZone™ Drawer with Metal Cooling cools food faster and provides an optimal place to store dairy, beverages and snacks. Adjustable Smart Divider is optimized for smart organization, easy access, and is kid-friendly. The Twin Cooling Plus™ feature maintains both high levels of refrigerator humidity to keep perishable fruits and vegetables fresher longer, and dry freezer conditions means less freezer burn for better tasting frozen foods. LED lighting gently brightens virtually every corner of your refrigerator so you're able to quickly spot what you want. Plus, it emits less heat and is more energy-efficient than conventional lighting. The sleek design saves more space than traditional incandescent light bulbs. The Ice Master produces up to 10 lbs. of ice per day and stores up to 4.2 lbs. of ice. This space-saving design leaves more room in the refrigerator.
- Food Showcase
- 5 Tempered Glass Spill-Proof Shelves | 1 Foldable | 1 Foldable Slide-In | 1 Slide-In
- 6 Door Bins | 1 Gallon
- On The Door Water And Ice Dispenser
- Automatic Ice Maker
- High-Efficiency LED Interior Lighting
- Energy Star® Certified
- Black Stainless Steel
- Twin Cooling Plus™
- Metal Cooling FlexZone™ Drawer
Samsung - 1.8 CuFt Over The Range Microwave
The Samsung ME18H704SFG/AA Black Stainless Steel Microwave features a durable Ceramic Enamel Interior that provides a polished surface that's easy to maintain. You can effortlessly remove grease or oil from surfaces. Plus, this interior is more scratch and stain resistant than plastic or stainless steel.
- 1000 Watts Cooking Power
- 10 Microwave Power Levels
- Black Stainless Steel
- Child Safety Lock
- Sensor Cooking
- Scratch Resistant And Easy To Clean
Samsung - Built-In Dishwasher
This stylish Samsung DW80J7550UG/AA Black Stainless Steel Dishwasher comes with many modern and convenient features. Samsung's Waterwall System provides a powerful wall of water that cleans hard-to-reach places and ensures a more even, thorough washing performance compared to rotary spraying systems. The Zone Booster feature offers flexibility to wash all types of dishes in 1 load and the ability to select the right or left zone to wash on the bottom rack. And it's Energy Star certified which means this dishwasher is energy efficient and easy on your wallet.
- 5 Wash Cycles And 5 Wash Options
- 5 Level Wash System
- Stainless Steel Interior
- 24 Hours Delay Start
- Electronic Touch Sensor
- Energy Star Rated
Samsung - 30" Electric Smooth Top Double Oven Range
The Samsung NE59J7850WG 30" Electric Smooth Top Range splits in to two ovens (2.7 CuFt Upper/ 3.0 CuFt Lower), so you can cook two dishes simultaneously at two different temperatures. Plus with the Dual Door you can open just the top section or full oven for cooking flexibility and energy efficiency. Easily and quietly close the oven door with the whisper-quiet Soft Close Door. The 5.9 CuFt capacity and Flexible Cooktop ensures you have the flexibility to cook multiple dishes at once. Then keep food warm in the Warming Draw until ready to eat.
- 5.9 CuFt
- Steam Clean Self Cleaning Technology
- Flex Duo® With Dual Convection
- Dual Oven Window
- Black Stainless Finish
- Dual Door™
- Soft Close Door
- Warming Drawer
Customers Who Viewed This Item Also Viewed...
Technical Specs ↑ Back to Top
|Installed Icemaker
|Energy Saving
Energy Star
|80.0 in
|45.0 in
|791 lbs 8.0 oz
|46.0 in


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These were very easy to design and the shimmer paper is beautiful. It gives the stationary just a little something extra. I used the ceremony cards as a menu card instead since our entrees need to be ordered before hand. (Posted on 6/22/2016)
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SJD Accountancy are the UK's largest specialist provider of fixed fee, Limited company accountancy services to contractors, freelancer's and small to medium sized businesses; we've been acting for contractors across the UK since 1992 and have more than 14,000 clients.
We are deemed IPSE Accredited Accountants and fully MSC compliant and are the only National specialist firm of accountants with offices across the UK.
SJD also have more qualified staff than any other firm in our market with qualifications from the following major tax and accountancy bodies – ATT, AAT, CTA, ACCA, CA, ACA, FCCA..
- Unlimited face to face meetings across the UK. Tax is complicated and sometimes only a meeting will do, which is why we offer unlimited face to face meetings across the UK.
- UK's Largest contractor accountants with more qualified staff. No call centres, no outsourcing, no automated call handling. Simply telephone, email or meet your own dedicated tax expert face to face.
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- Outstanding reputation. We have won more awards for customer service and accountancy excellence than any other firm in our market.
On top of all that, SJD have also won every relevant industry award possible, including:
- Best Contractor Accountants – Contractor UK 2016 – 2007
- Accountant of the Year – The British Accountancy Awards 2011
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- Customer Commitment Award – Institute of Customer Service 2011
- National Chamber of Commerce Award 2010
- Medium firm of the Year – Finalist Accountancy Age 2010
- Excellence in Customer Service – Finalists National Customer Service Awards 2009
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Our complete business package covers all your company needs and personal tax affairs for a fixed fee of just £120 plus VAT per month. This includes:
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As specialists we can, of course, offer advice on IR35 implications, assist on contract reviews and suggest ways in which your business might be structured to take it outside this legislation.
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If you are thinking of contracting through your own company, you could also read our new straightforward guide on How to Contract through your own Limited Company . You'll be surprised how little time it takes and just how easy it is.
You may also like to read our Guide to Contractor Expenses and take home pay case studies of a contractor using an umbrella company and another who's working through their own limited company.


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Frozen Synapse Update Gives Gamers Mini-Tournaments
Frozen Synapse developer, Mode 7 has just released a clean version of the game after its first official patch. The patch includes a number of tweaks in addition to some awesome new features.
Before I continue on, for those who are unfamiliar, Frozen Synapse is a PC and Mac turn-based strategy game, that allows you to command your squad members to carry out actions for you- kinda similar to Mass Effect 3, or a traditional game of chess.
A synapse, of course, is the junction between two neurons, and is vital for your brains chemicals to successfully 'move around', let's say.
Anyways, one of the new features of this game is tournament mode, which allows competition between larger groups rather than simplistic one-on-one play. Now, keep in mind, this is still two-player gaming for individual matches, but with the new tournament structure rolled out, larger groups can dive in for a mini-championship.
You can grab the full list of changes from the new patch here, and you can officially download the game from the Steam platform directly to your PC next week.
Send us a tweet @techmento and let us know what you think of the patch, and if you'll be downloading the new version to your PC? Check out the video below to get a scoop on the gameplay.


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World news story
UKinSouthAfrica mark Climate Diplomacy Day
UKinSouthAfrica mark Climate Diplomacy Day and share UK core climate messages in South Africa.
BHC Pretoria teamed up with the EU delegation, German, Danish, French and US embassies here to mark Climate Diplomacy Day, and promote our core climate messages to a SA audience. Our event was hosted by University of South Africa (UNISA) – one of SA's leading universities - on the morning of Wednesday 17th June and attracted a full crowd looking to engage on our theme of Why We Cannot Fail: Road towards a Climate Change Agreement in Paris.
The event was opened by a representative of UNISA's Vice-Chancellor. Vice-Principal Professor Divya Sinch emphasised the importance of climate action from a societal and business standpoint, as well as a personal one. She stressed the need for urgent action to prevent dangerous climate change: "the future is now."
EU, French and German HoMs used the platform to stress the need for global climate action, the importance of the Paris COP and convey EU unity on the agenda. The German spoke of how economic development could/should go hand in hand with a move to low carbon. An industrialised nation like Germany had still chosen to successfully pioneer energy efficiency and renewables. In her speech, the High Commissioner called for an ambitious deal in Paris, explained the steps being taken by the UK (including on renewables), and highlighted our climate-related projects in South Africa, including via the Prosperity Fund (Judith's speech attached).
A subsequent panel discussion included Simon Cardy from DIRCO, representing SA Government, Louise Naude from WWF, Xolisa Ngwadla from the Council for Scientific and Industrial Research (CSIR) and a postgraduate student from UNISA. The discussion was frank and held together by the common thread of SA's developing nation status and how it plays into what can be expected in terms of climate action. Cardy positioned SA as the leading African nation (and one of the leading emerging economies) pressing for an ambitious deal, with a strong emphasis on a deal being legally binding: there could be no place for a "go it alone system". He noted the risk of a political deal which might not fulfil the basic science/climate requirements – the numbers had to add up. Naude (WWF) was moderately positive about SA's climate credentials but urged SA to match rhetoric to reality and decommission all coal plants (as well as rule out shale gas and nuclear!).
Document information
Published: 24 June 2015
From: British High Commission Pretoria
Part of: South Africa


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- AnonymousMarch 5, 2012 at 9:36 PM
promo of the next episode is missing :((ReplyDelete
very interisting dramaReplyDelete
- AnonymousMarch 7, 2012 at 5:30 AM
very interesting can we have the rest.I laughed somuch when I saw humayun Saeed with a cap on his head and a tasbi in his hand. This is a fact of life today and it is a very sad fact.ReplyDelete
- AnonymousMarch 7, 2012 at 5:32 AM
hats off to Ayesha Khan,for playing this role. Izzat is very brave and bold despite all that has happened.need more women in real life like her.ReplyDelete
- AnonymousMarch 8, 2012 at 6:54 PM
well there is one thing, if you have noticed at the beginning of this drama Izat was working in some office and the boss of that office wanted that receptionist girl and Izzat went to his office and recorded his voice and told him if he will bother the girl she will do something. NOW when Hisham is keep calling Izzat why is she not recording it????????ReplyDelete
- AnonymousJune 22, 2012 at 8:28 AM
Hmm intressting verry verrry!!hehehashahReplyDelete


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My friends said it wasn't rude maybe I'm over reacting but I think it is what's the point of it. that person can wait till I leave and eat and not eat while they're talking with their mouth full. it was discusting. so I wanted to know is their any person like me or I'm the only one :).
Most Helpful Girl
its a little bit rude. kinda gross. unless ur on lunch and only have a certain amount of time. haha! wow, that was pretty bold for them to do. at least swallow before you talk, ya know. geez...00|00|0
It wasn't lunch time only when I approached that person in the office and started to talk.
what a pig!


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Michael Simmons, class of '64, died Feb. 7 in Florida at the age of 77. His gift to the Michael Simmons Student Activity Endowment will "continue to inspire Simmons' love of teamwork — and the lifelong skills it instills — and will touch countless Sycamores for generations to come," according to a news release from the university.
Indiana State University President Dan Bradley recalled Simmons, his friend, as being creative, competitive and generous.
Simmons, for instance, co-founded the Sycamore Tricycle Derby in October 1963 as a way to keep students on campus during the weekend.
The "Trike" race was nurtured by students and staff in the 1970s and '80s before growing into the homecoming tradition it is today. It also spurred the idea for a tandem bicycle race each spring — both of which are now headquartered in the Michael Simmons Activity Center.
Simmons was about impact, not praise, Bradley said.
"Although he humbly accepted the honors that came his way, his actions were never about drawing attention to himself," said Bradley. "They were always about the effect they would have on shaping or transforming our students."
Simmons' contributions will be honored at this year's Tandem Race with a moment of silence and memorial parade lap at 10:45 a.m. on Saturday.
The Michael Simmons Student Activity Endowment was established in 2013 to increase student participation in extracurricular, team-based programs that foster the development of leadership and teamwork skills. The funds are distributed through an application process.
"He was a personal friend who I admired greatly and aspire to be more like," Bradley said. "We will miss Michael, greatly but his spirit will continue to resound through our campus."
Editor, John C. DePrez Jr.; Executive Editor, Carol Rogers; Publishers: IBRC and IAR


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"Policing is my area of expertise. I've always been interested in the impact of policing on public perception and crime." Tammy Kochel paused, gathering her thoughts. "I felt obligated to do the study because I had a unique data set that provided baseline views on how county residents felt about police prior to the Michael Brown shooting and unrest. I could offer knowledge that other researchers were not positioned to be able to."
As associate professor of criminology and criminal justice at Southern Illinois University, Kochel surveyed residents of St. Louis County, Missouri, between 2012 and 2013. She gathered data "on how different kinds of policing strategies in hot spots of crime impact public perception of police."
After the events in Ferguson, Missouri, in August 2014, Kochel saw an opportunity to revisit the 2012-13 study. In September and October 2014, she gathered data on the public's perception of police legitimacy and public trust, examining how the event in Ferguson affected the community. A recent follow-up study with the same residents examined the long-term impact, nearly a year later. Kochel also interviewed police personnel who were intimately involved with handling the unrest in Ferguson.
Though she and her team at SIU are still analyzing data, Kochel found two interesting results from the surveys. The initial impact showed that trust in police and perceptions of police legitimacy declined considerably among African-American residents living in high crime areas in St. Louis County—Ferguson is in the northern part of this county—while other residents' views remained stable. More recently, perceptions among these same African-American residents show improvements, while non-African-American residents show an 8 percent decline in trust since October 2014.
Results from her study were cited in the U.S. Department of Justice's most recent collaborative reform report on the St. Louis County Police Department.
Kochel is partnering with the Charles Koch Foundation to continue the study. Part of the plan is to do a follow-up survey with police officers to continue exploring the impact on policing in St. Louis County.
Kochel's goals for the study reach beyond the academic sphere. She would like to see the results inform strategies for improving the public's relationship with and trust in police.
The Charles Koch Foundation requests proposals from scholars like Kochel who are already working to understand the challenges facing our criminal justice system and work towards solutions.


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Supporters from as far away as Canada have sent money to Casey Anthony's jailhouse commissary account since she was acquitted of killing her 2-year-old daughter.
Records released Thursday show Anthony's account has gone from around $264 just before the jury verdict last week to more than $470.
Supporters are sending the checks and money orders to the Orange County Jail, where Anthony is scheduled to be released Sunday.
Anthony was found guilty of four counts of lying to police, but with time served and good behavior credits, she won't serve out her four-year sentence.


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(The third book in the Alvin and the Chipmunks series)
A novel by Perdita Finn
The Chipmunks and The Chipettes are enjoying the time of their lives on a spectacular cruise ship until . . . munk overboard! When the gang follows Alvin to the shore of a deserted island far away from their travel accommodations, they wonder: will Dave come to their rescue or are they washed up for good?
Used availability for Perdita Finn's Chipwrecked
See all available used copies of this book at Abebooks UK or Abebooks US
Paperback Editions
October 2011 : USA Paperback
|Title: Alvin and the Chipmunks: Chipwrecked- The Junior Novel
Author(s): Perdita Finn
ISBN: 0-06-208658-8 / 978-0-06-208658-7 (USA edition)
Publisher: Harper Collins Publishers India
Availability: Amazon Amazon UK Amazon CA
Genre Pages


text: Sorting type: Most visited Most visited Alphabetical | Pages in category "Resident Evil 5 Mercenaries" " Contents[show] Points Ranks There is no "F" rank; the only way to 'fail' is to die. Enemy Score... The Mercenaries (RE5) score guide Subcategories Resident Evil 5 Mercenaries maps Retrieved from "http://residentevil.wikia.com/wiki/Category:Resident_Evil_5_Mercenaries?oldid=434741" Ad blocker interference detected! Wikia is a free-to-use site that makes money from advertising. We have a modified experience for viewers using ad blockers Wikia is not accessible if you've made further modifications. Remove the custom ad blocker rule(s) and the page will load as expected. Categories: Resident Evil 5 minigames


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Cisco Wireless LAN controller is ideal for small, mid-sized, enterprise business and service provider wireless LAN deployments and provides system-wide wireless LAN functions, such as security policies, intrusion prevention, RF management, quality of service (QoS), and mobility. It works in conjunction with Cisco lightweight access points and Cisco Wireless Control System (WCS) Software to support business-critical wireless applications.
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Great place to stay for 1 night. Close to the Marine Museum and not far from Potomac Mills and restaurants.
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I would stay here again because the staff was great!!
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NEVER TOLERATE TYRANNY!....Conservative voices from the GRASSROOTS.
15 members
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Patty has not received any gifts yet
Is this the America we want to leave to our children?
Florida is a TIE in ballots cast dems 40% and repubs 40.4 %. Independents 20%. Everyone your vote MATTERS this time! Independents your votes matters more than ever - don't waste it!!!! Do you want to tell your children and grandchildren that you cast the deciding vote…Continue
Posted on November 1, 2016 at 10:00pm
Posted on August 1, 2016 at 6:30am
Paul Ryan wouldn't stop and talk to moms who lost their beloved children to open borders!
Posted on July 25, 2016 at 6:36pm
POLL: Support For Paul Ryan Plummets In Wisconsin, Challenger Paul Nehlen Surging……Continue
Posted on July 10, 2016 at 4:30pm — 2 Comments
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Fully renovated farmhouse running as a charming bed and breakfast
15 minutes from Avignon airport
Farmhouse dating from the 19th century, completely renovated in 2010 with approximately 350 m2 of usable space, with south-facing aspect and in the shade of a superb plane tree.
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On the ground floor: entrance hall, lounge dining room with fireplace, fully equipped kitchen, library, bedroom with bathroom, study, 1 loft suite with bedroom, sitting room and bathroom on mezzanine, boiler room and laundry.
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It is very rare to find a property with such refinement and attention to detail


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Faux bamboo is the perfect way to jazz up your room! Everyone from Kelly Wearstler to Jonathan Adler has embraced this Hollywood regency style!
This glossy white faux bamboo table lamp is from the 1960's and in fabulous vintage condition.
This lamp would look so pretty on a nightstand or desk.
It has been completely re-wired with a 3-way socket and has all new brass hardware.
The lamp base (excluding the neck, socket, and harp) measures 13.5 inches tall, so it is the perfect table lamp.
This lamp is priced at $95. Local pick-up available in Charlotte, or it can be shipped for $10. Please note that in order to keep shipping costs low, the shade is not included. You can easily buy a shade to fit at Target or Pottery Barn. You can use it with or without the harp, depending on what shade you choose and how tall you want it to be. Email us at firstname.lastname@example.com if you are interested!


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The Lighting Bible® 12 is extremely ambitious in its scope: over 1,000 pages packed with new designs, new applications, technical innovations and inspirational project photos from allover the world. Some of the new collections were shown for the first time during Milan Design Week in an impressive setting, and were received with great enthusiasm.Discover New Collection
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For Milan Design Week, Delta Light turned the surroundings of the historic Palazzo Crivelli into a monumental lighting installation. Brand new products were displayed in a conceptual setting, including designs by architects OMA, lighting designer De…Discover more
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Personalised Oak Keepsake Box Wedding Memories Ref: MLM208
This solid oak Keepsake Box is the perfect way to store memorabilia from your 'big day'. Store your order of service, confetti, your something blue, the speeches or dried flowers from your bouquet......whatever you want to remember your wedding day.
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Please ensure spelling is correct before submitting, bespoke personalisation is case sensitive and will be copied exactly. Changes cannot be submitted once in production.
There are two sizes available: standard medium size 30 x 20 x 20cm and our larger box, which can fit A3 documents, 46.5 x 34.5 x 16.5cm.
Made from:
The box is made from solid oak.
As wood is a beautiful, natural product, the colour and grain does vary from tree to tree meaning the product will slightly vary from the pictures shown.
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The former bookkeeper for a nonprofit that collects and distributes funds to various medical research agencies has been charged with mail fraud after she allegedly embezzled about $715,000 from the organization.
According to a bill of information filed last week at U.S. District Court, Patricia Blanchard, 67, embezzled the money from an unnamed charity, of which her husband was president and executive director, between 2006 and November 2011. She allegedly did so while working for Association Management, an independent contractor.
Blanchard and her husband, George Blanchard, incorporated Association Management in 1999, according to Louisiana Secretary of State's Office records.
The charity is identified in court documents only as "Charity A." George Blanchard, however, listed himself as president and CEO of Community Health Charities on his LinkedIn profile.
The bill of information states that Patricia Blanchard's husband, identified in the document as "G.B.," was hired as the president of the charity through Association Management.
Tax returns prepared for Community Health Charities of Louisiana and Mississippi for 2007 were signed by George Blanchard and list Association Management as one of the charity's five highest-paid independent contractors. The tax documents note that George Blanchard was a 49 percent owner of the company, while Patricia Blanchard was listed as a 51 percent owner of the company.
Harold Samorian Jr., president of Community Health Charities in the southeastern part of the country, said George Blanchard is no longer president of the Louisiana-Mississippi office.
George Blanchard, who has not been accused of any crime, arranged to have Patricia Blanchard hired as the bookkeeper for the charity in 2005, according to the bill of information.
Patricia Blanchard appears to live now in San Antonio, according to public records. Numbers listed for her in public records were all disconnected. Her attorney, James Washington, did not respond to messages seeking comment.
According to the bill of information, Patricia Blanchard defrauded the charity three ways:
- First, it says, she would mail checks from the charity's bank account to pay her own credit card bills. She would make fictitious notes on the checks, such as "Cancer Research Institute," "March of Dimes" or "American Cancer Society," in an attempt to make them look legitimate.
- Second, she would obtain cash advances on a personal gasoline credit card and reimburse herself from one of the charity's accounts to make it look as if she was repaying herself for travel and gas expenses.
- Third, she would pay for personal items directly from the charity's bank accounts without authorization.
The charity's 2010 tax return says it contracted with a "third-party management company" from 2000 until December 2010 for its executive director. While the bill of information claims that Association Management was used by the charity beginning in 2000, the tax return claims that company was used only between July 2010 and December 2010.
A new executive director was hired in January 2011 after "the employees of the management company retired and the agreement with the organization was mutually terminated," according to the tax return.
After the new executive director was hired, he and the board became aware of "potential misappropriation of funds by the third-party management company" after an account statement found $191,798 in expenses that could not be documented and that were not approved by the board of directors, according to the tax return.
The tax return notes that the charity had hired attorneys and was "considering options for recovery of the funds."
"The local leadership has been actively involved in providing information to, and supporting the work of, authorities investigating this matter and is pursuing every avenue on behalf of its member charities," Samorian said.
If convicted, Patricia Blanchard faces a maximum prison term of 20 years and a $250,000 fine.


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I drafted several questions that Harris Decima included in a nationwide phone survey two weeks ago, the results of which have been released here over the last couple of days. In this final piece, the focus is on expectations of Canada at Copenhagen, blending economic and environmental matters, and what President Barack Obama means for expectations of our own government. Here's what we found:
• Half the sample (500 of 1,000 respondents) was read: "Canada should do as much as it can to solve the climate change problem." Ninety four per cent of the sample agreed with that statement. An unequivocal declaration of support for action, it would seem. But is it completely unequivocal?
• The other half of the sample was presented with "Canada should do as much as it can to solve the climate change problem, without putting too much pressure on the economy." Enthusiasm for this version of our commitment stands at 80 per cent.
In one sense, this is hardly revelatory: if offered the choice, people would like to have the best of all possible worlds. But it also reflects the same trepidation that affected support for Stéphane Dion's Green Shift. Voters evaluate government holistically, rather than looking at prosperity or sustainability in isolation. They want government to make reasoned choices, not only to embrace their passions.
The arrival of President Obama on the world scene has altered the dynamics of the debate, in ways that are important to Canadian politics.
• 74 per cent agree with the statement "Barack Obama will try to accomplish as much as possible in terms of environmental improvements." (Asked of half the sample)
• 60 per cent agree with this "President Obama will not be able to agree to do much to reduce emissions, given the weakness of the U.S. economy." (Asked of the other half)
Clearly, a lot of people are giving the U.S. President something of a bye on this round. He is so well regarded here, his values so broadly trusted, many will assume that whatever he proposes will be the best he can do, and likely as much as is possible. His predecessor has a much different relationship with the Canadian public, to put it mildly.
The idea that policy in Washington should determine environmental or economic policy for Ottawa usually riles Canadian voters. So when the Harper government says its climate policy will dovetail with that of our biggest trading partner, how does that argument land here at home?
Once again, the arrival of President Obama has changed our politics. By a margin of 59 per cent to 33 per cent Canadians agree with this statement "If Canada matches the kind of commitment the U.S. makes to fight climate change under President Obama, I will be satisfied."
Because most Canadians trust President Obama they can interpret our policy as aligning with someone who shares their concern with the planet, in a way they didn't feel with Mr. Bush in office. Describing our policy as mainly a question of economic self interest won't resonate as well as describing a partnership with a President who is seen to be progressive, but struggling with massive economic problems that we know affect us too.
Through this short series, I hope I've illustrated a few things:
• Canadians are quite concerned about the state of the planet and want to see the country push hard for solutions. But this is support for a direction, not the same as in depth knowledge of trade offs and rock solid attachment to individual solutions.
• People want governments to hear them, embrace their values, evince their passions, but they also expect governments will act prudently on their behalf, weighing pros and cons of different solutions with an eye on practicality and affordability.
• The audience for environmental matters is large, engaged, and still fluid. Opinions are subject to change based on information, advocacy, argument. The only views that will be ignored are those of people or institutions that appear not to care about the environment at all.
(Photo: Adrian Dennis/AFP/Getty Images)Report Typo/Error


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Johannesburg - The Johannesburg Tourism Company (JTC) has been nominated as World's Leading Tourist Board at the World Travel Awards 2012.
"This being the second time Joburg Tourism has been nominated, we're thrilled with the news, and call on all our stakeholders to please support our nomination by voting online for JTC," acting JTC CEO Phelisa Mangcu said in a statement on Tuesday.
Now in its 19th year, the World Travel Awards is regarded as the highest achievement in travel, tourism and hospitality.
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A vote cast by a registered travel agency employee carries a weighting of two, while the consumer vote counts as one vote. - Sapa