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Filesystem operation filtering - now in user-mode
CallbackFilter lets you create a filter driver in user mode, right in your .NET, C++ or VCL (Delphi) application.
What CallbackFilter offersCallbackFilter provides a ready-to use filter driver (not a minifilter) that intercepts requests going to the filesystem and calls your user-mode code. Your user-mode code receives the request and can process or deny it based on any criteria you like. In many cases you can also alter the data being read or written from/to the disk. You can even create virual files and directories.


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My name is Dagan Brown and I am a member of United Students Against Sweatshops at Columbia University and Barnard College, USAS local 31. The Barnard college contingent faculty, like contingent faculty across the country, had been subjected to deplorable working conditions at one of the country's most prestigious universities. Facing poverty wages, an exorbitantly expensive healthcare plan that few contingent faculty could afford, and the pressure to juggle the instruction of multiple courses in order to make end's meet, the Barnard contingent faculty drew upon their power as unified workers and in the Spring of 2015 formed a union: the BCF-UAW Local 2110.
For almost two years now, Barnard Contingent Faculty have been fighting for a fair contract. Students have been with them every step of the way. From collecting more than 700 student signatures in support of a fair contract, to organizing demonstrations and rallies in order to show solidarity, students have been instrumental in the fight for a Barnard that respects all faculty. After months of struggle, the Barnard contingent faculty have won a fair contract! Leading up to this incredible victory, contingent faculty were threatening to strike. Recognizing that these workers are the backbone of their school and that students will rally behind them no matter what, Barnard ultimately had to meet their demands. The same day that the fair contract was announced, our USAS chapter held a celebration rally with dozens of people in attendance.
Here are some highlights from the newly won contract:
- Starting in 2020, the minimum base pay for courses of three credits or more will be $10,000, an increase of $5,000 from the current minimum
- Term faculty will receive $70,000 per year at minimum, an increase of $10,000 from the current base pay.
- The college will put 50 percent of their contribution toward benefits—which include dental, vision, and medical benefits—for adjuncts teaching nine credits or more in an academic year, while faculty not meeting this threshold will be able to purchase a plan at full value.
This victory could not have been achieved were it not for the forces of students and workers coming together.
In Solidarity,
Dagan Brown
Columbia University
USAS Local 31

subset: commoncrawl


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Experience the Swiss precision, engineering, and style of BMC at City Cycle. We have the best selection of road, mountain, and urban BMC bicycles in the Bay Area.
No, it doesn't travel back in time, but BMC's Timemachine TM02 will get you to the finish line faster than Doc Brown's DeLorean. BMC's truncated carbon tubing melds incredible aerodynamics with unflinching stiffness. Tripwire technology employed at the leading edges disrupts turbulence and reduces… [more]
Float up the climbs with BMC's Teammachine SLR02. The incredibly light frame features subtle damping and vertical plasticity to reduce fatigue and provide a luxuriously comfortable ride. BMC's engineers also optimized tube shapes and lateral rigidity so your power gets red carpet treatment straight… [more]
Comfort, stability, and power are yours with BMC's Granfondo GF02. Developed for the cobbled roads of northern Europe, the GF02 damps road chatter and puts you in a slightly upright, comfortable endurance-oriented riding position. Its surprisingly light, stiff, triple-butted aluminum frame… [more]
BMC's Teammachine SLR03 delivers a crisp yet smooth ride, equally at home in the hills as the flats. The incredibly light frame features subtle damping and vertical plasticity to reduce fatigue and provide a luxuriously comfortable ride. BMC's engineers also optimized tube shapes and lateral… [more]
BMC's Teammachine SLR01 will change your climbing experience—ascents will look steep, but feel flat. The unbelievably light frame is a favorite of Grand Tour climbers and sprinters alike due to an ingenious marriage of subtle damping and compliance for reduced fatigue with tube shapes optimized to… [more]
BMC completely redesigned the carbon manufacturing process to create the utterly flawless, beautiful and unbelievably fast Impec. Hand built by machines in Switzerland, this thoroughbred is the realization of BMC's innovative vision. Perfectly woven, individually tailored LSW carbon tubes are… [more]
Don't get regular call ups? No worries, BMC's Crossmachine CX01 will soon earn you the front row every race. BMC's top-of-the-line ACE carbon construction is light, stiff, and compliant in all the right places. A beefy bottom bracket and down tube give you the power to charge for the inside line,… [more]


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Was killing time walking around menards and noticed B&B mesquite lump charcol. It comes in 8 lb bags for $5.44. Wondering if anyone has experience with this.
post #1 of 3
8/21/15 at 8:51am
Thread Starter
That's 68 cents/pound for charcoal. Wait another week and you can stock up on Kingsford Original at Lowes or Home Depot for about 27 cents/pound.
Early on I read that charcoal infused with wood, especially a strong wood like mesquite, is not recommended for smoking. Can add too much smoke flavor to the meat.
Charcoal infused with wood is for grills. It lets you grill your meat and get some smoke flavor into it at the same time. I'd personally avoid it for smoking, unless you don't intend to use any wood during the smoke. Frankly I don't think it does much good in either case. It's really more a gimmick. But that just my $.02.


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Dr. Scott Reuben just plain faked the results. He reported in two published articles that he had treated 200 patients in a trial - 100 with placebo and 100 with celecoxib (Celebrex). He simply made up the findings and never enrolled any patients at all. Multiple medical journals have retracted more than 20 articles by Dr. Reuben containing faked data on a number of pharmaceutical drugs.
Besides the faked research, he spoke frequently at medical conferences and continuing medical education events about using Celebrex and Vioxx in combination with other analgesics to reduce postoperative pain. The pharmaceutical companies reimburse their expert speakers very well and he will be repaying $361,932 to Merck and $296,557 to Pfizer.
Dr. Reuben's attorney stated that an undiagnosed bipolar disorder was the cause of his misdeeds.


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From the Wikipedia page [1]
Deans Brook is a stream which runs between Mill Hill and Edgware in the London Borough of Barnet. It is a tributary of the Silk Stream, which is a tributary of the River Brent, which is a tributary of the River Thames.
The brook rises on Mill Hill Golf Course,, and passes through a culvert under the M1 motorway to Stoneyfields Park, where it is dammed to form an ornamental lake. It then passes through suburban Edgware, where is combines with the Edgware Brook to become the Silk Stream near Edgware Hospital.
The stream largely follows its natural course, but most of the banks are restrained by wooden boards, and there is little aquatic vegetation. Kingfishers and grey wagtails are regularly seen along the brook.
The only part of the brook which is accessible to the public is in Stoneyfields Park. Deans Brook, Stoneyfields Park, allotments to the east of Edgware Hospital, and wetland south of Edgware tube station sidings together form a Site of Borough Importance for Nature Conservation, Grade II.


text: I have a question for the gang across the pond. Is anyone familiar with the pocket dosimeter from the late 1950's, early 1960's? To be more specific, the "Direct Reading Pocket Ionization Dosimeter" AKA "Quartz Fiber Dosimeter" manufactured by the RA Stephen & Company, Ltd. of the UK. Here's a photo of what they look like.


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1/2" W x 96" L V-Belt 1 Rib 4L960
DAYTON| Zoro #: G1772382| Mfr #: 4L960
Zoro #: G1772382Mfr. Part #: 4L960
Zoro #: G1772382Mfr. Part #: 4L960
$15.68 /ea
Orders over $50.00 ship free. DetailsStandard ground shipping
Technical Specifications
|Zoro #: G1772382 Mfr #: 4L960
|Thickness: 5/16"
|V-Belt Section: 4L
|Item: V-Belt
|V-Belt Type: V-Belt
|Number of Ribs: 1
|Material: Fabric Cover, Rubber Body, Polyester Cords
|Top Width: 1/2"
|Construction: Wrapped
|Outside Length: 96"
|Industry Number: 4L960
|Country of Origin (subject to change): Philippines
Product Description
V-Belt, Industry Number G1772382, V-Belt Section 4L, Number of Ribs 1, Outside Length 96 In., Top Width 1/2 In., Thickness 5/16 In., Material Fabric Cover, Rubber Body, Polyester Cords, Construction Wrapped


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Before and After Gallery
Vericose and Spider Veins
This advanced treatment for spider veins involves the injection of a solution into the vein causing it to swell, then collapse, and seal shut. The vein turns to scar tissue and fades within several weeks. Treatment is rapid and very comfortable. Patients with a large number of spider veins may require multiple treatments.


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Dark Elves —— The Road To Palus Knight (Lineage ii extreme)
The Road to PALUS KNIGHT You need to be in Gludio and go talk to master Virgil at the Dark Elf Guild. He will tell you to collect 13 Lycanthrope skulls from the neutral zone for A Skull Ceremony. "A … Continue reading
Dark Elven Mage Guide To Leveling 1-20 (Lineage 2 chronicle 5)
Welcome to the world of Aden. I will be your guide through your travel from level one to twenty. I will help you to become the most ruthless and evil mage in Aden by helping you find key quests, shops, … Continue reading
Dark Elven Guide To Leveling 1-20 (Lineage 2 skill)
Welcome to the world of Aden. I will be your guide through your travel from level one to twenty. I will help you to become the most ruthless and evil fighter in Aden by helping you find key quests, shops, … Continue reading
Dark Elf Fighter Skills And Strategies (Ncsoft Lineage)
I'd like to preface by saying this probably applies to any type of fighter character. Skills and using them correctly can turn the tide of battle greatly, or prevent you from losing precious XP. First of all you should know … Continue reading
Dark Elf – Detailed Mage Guide Levels (Lineage 2 hack)
Intro This guide will explain the best places to level and what quests to do to get you started on your way. This guide will also explain what spells do what. And monster statistics of what you should hunt at … Continue reading
Coin Of Magic Quest Details (Lineage chronicle)
Note this is only for The level 3 members as this is about as far as I have gotten. This quest can be started at lvl 40. The quest starts out in Hunters Village from Warehouse Keeper Sorint. After … Continue reading
Chronicle 2 – New Skills By Profession (Lineage 2 items)
Here's the new list of skills coming in C2 by profession, and the levels at which they are attained. Professions are listed in alphabetical order. Abyss Walker – Drain Energy – lvl60, 62, 64, 66, 68, 70, 72, 74 – … Continue reading
Cave Of Trails Pathing Issue (Lineage 2 subclass)
An interesting pathing exploit on Orc Island in Elmore (Orcville as I like to call it). On the eastern part of the island, you'll find the lovely Cave of Trails. As soon as you enter and cross the small bridge … Continue reading
Carry A Ton Of Extra Weight (Lineage 2 powerleveling)
Here's a nifty little trick in L2 that will allow you to carry a ton of ss (or anything else you need arrows etc) without it impacting your overall weight percentage. For instance, load up on 15000 c-ss, to the … Continue reading
C2 Weapon SA's (Lineage 2 tattoo)
A Grade Blood Tornado SA=crt.drain SA=haste SA=rsk.evasion Bloody Orchid SA=backblow SA=evasion SA=focus Carnium Bow SA=crt.bleed SA=manaup SA=quickrecovery Dasparion's Staff SA=magicweakness SA=manaup SA=magicchaos Halbard SA=crt.stun SA=longblow SA=wideblow Meteor Shower SA=focus SA=health SA=m.focus Tallum Blade SA=health SA=rsk.evasion SA=rsk.haste B Grade Art of … Continue reading


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The Gauntlet Game
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See how far you can guide the red dot through all of the ever shifting block maze without hitting any of the block walls.
Use your mouse to Left-Click the red dot as you guide it through the block maze.


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Cupid's Chicken 'n' Stuffing Recipe
This main dish looks attractive and is easy to fix. The chicken stays moist, and the savory stuffing that bakes right with it is the perfect accompaniment.—Barbara Birk, St. George, Utah
- 1 package (6 ounces) seasoned stuffing mix
- 8 boneless skinless chicken breast halves (4 ounces each)
- 1 teaspoon canola oil
- 1/4 teaspoon salt
- 1/4 teaspoon pepper
- 4 Swiss cheese slices (2 ounces), halved
- 2 tablespoons butter
- 1 can (10-3/4 ounces) condensed cream of chicken soup, undiluted
- 1/4 cup water
- 1. Prepare stuffing mix according to package directions. Transfer to a greased 13-in. x 9-in. baking dish. In a large skillet, brown chicken in oil. Sprinkle with salt and pepper; place over stuffing. Top with cheese. Drizzle with butter.
- 2. Combine soup and water; spoon over stuffing. Cover and bake at 350° for 40 minutes. Uncover; bake 10-15 minutes longer or until chicken juices run clear. Yield: 8 servings.
Nutritional Facts
1 each: 331 calories, 14g fat (7g saturated fat), 92mg cholesterol, 734mg sodium, 19g carbohydrate (3g sugars, 0 fiber), 29g protein.
Reviews for Cupid's Chicken 'n' Stuffing
Average Rating
Reviewed Sep. 17, 2012
"Nice, easy, basic recipe. I used cheddar cheese."
Reviewed Oct. 20, 2011
"This is one of my family's favorites!"
Reviewed Jul. 27, 2011
"This definitely a keeper in my recipe box.DELICIOUS!!!!! I think you might nothave to cook the chicken as long as the recipe says. I think it depends on howthick the breasts are. This is so good!"
Reviewed Dec. 19, 2010
"Made with chicken cutlets instead, very tasty, will make it again!"
Reviewed Jul. 25, 2010
"This has become a family favorite. I've used many different substitutions of cream soups and cheeses, depending upon what I have on hand. If I'm in a hurry I omit browning the chicken first."
© 2017 RDA Enthusiast Brands, LLC


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But there are still a few things that I want to remember about last night (that sounds so spicy!), so before I add a note about today's adventures (there was more than one!), I'll write a few words about two hours of free time I had yesterday. Because I can.
Let's start with my destination. I guess by now pretty much everybody has heard about Hamacho Park (in Tokyo, obviously) which is said to be a home to many rare Pokémon. And the world is playing Pokémon Go. Well, I don't know about the world, but I can tell you this: Japan IS playing Pokémon Go. I went to this park because it was close but when I saw that it was crawling with Pokémon Go players, I decided to check if the rumors were true. 10 minutes of playing, dozens of Pokémon caught. Some of them definitely rare.
So if you are in Tokyo and into catching them all, you should definitely go there. If you're not playing the game – avoid this place. It is really crowded and I'm not sure who thought it would be a good idea to call such a small strip of green a park – this is not a park.
So yeah, it's not that I'm not enjoying this game. I am. Seriously. But I don't want to spend my limited time here looking at my cellphone.
I'm not sure if I've already said that, but I live in a land of bridges. I cross 3 or 4 bridges a day. Some of them small, some enormous. I used to be scared of bridges (something to do with my inability to swim and my fear of heights) but I'm not anymore (at least not of the small and medium ones) which is really good. Because:
And these are not all the bridges I had to cross yesterday. I think there were four or five. I would like to know if this river/canal/water-thingy has a name, somehow my Google Maps refuse to show me its name. [Update: Yes it does. It's Sumida River. Of course!]
Anyway, a park, Pokémon, bridges, it was all very nice but the best thing that happened yesterday was me winning some strange lottery in Family Mart! Found it (supermarket, not a lottery) on my way back and as I run out of food supplies (and was I'll-eat-you-alive hungry), I just had to check it for presence of food with English subtitles 😉 or English-speaking personnel. Discovered my favorite Scotch pancakes (I still can't believe I buy them in Japan), delicious bread, and… milk!
Checkout lady new only one English word: "one." But that's ok because that was enough. This is how she told me to take one lottery ticket from a box (I saw some guy doing that before me so I knew what to expect). And I won a soda! I know it's not much but c'mon, I won a soda in Tokyo even though I have no idea why and how!
I'm not even sure if I this is a soda. It tastes like a sparkling lemonade. I like it.
(Note to self: I really need to learn more Japanese.)


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Giovanni Items16 textbooks were found
List Price:$9.50
Lettera di Giovanni da Empoli a Leonardo, suo padre, intorno al viaggio da lui fatto a Malacca e frammenti di altre lettere del medesimo, aggiuntavi ... Girolamo da Empoli, suo zio (Italian Edition)
List Price:$14.99
List Price:$14.99
The Texts and Versions of John De Plano Carpini and William De Rubruquis: As Printed for the First Time by Hakluyt in 1598, Together with Some Shorter PiecesList Price:$32.75
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BookRenter.com's 5-Star Satisfaction Guarantee
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Fill in the giveaway information, and you'll be entered to win a copy of United Tastes of Texas: Authentic Recipes from All Corners of the Lone Star State by Jessica Dupuy (Oxmoor House, 2016). (ARV $24.95)
Note: You can enter this giveaway one (1) time per e-mail address per day. Deadline is 11:59PM ET 10.22.16.
They say everything is bigger in Texas and that includes flavor. United Tastes of Texas is your culinary guide to Texas based on five regions: Central, Coastal, East, South, and West Texas. Chapters begin with a short history of the region along with facts and stories on local chefs and restaurants and then move into the food. Overall there are 125 recipes that include Texas takes on Black-Eyed Peas, Easy Guacamole, Smoked Brisket and Chicken Fried Steak. These are just a few of the dishes that illustrate how big Texas flavor can be.
To make sure you're kept abreast of our latest giveaways, subscribe to our new giveaway-only feed. If you want to stay on top of our recipes and writings, subscribe to our general feeds, e-mails, or digest in the column to the right. Visit our FAQs page, if you have questions.
NO PURCHASE NECESSARY TO ENTER OR WIN. Void where prohibited by law. Open to legal residents of the 50 U.S., D.C. and Canada (excluding Quebec) who are at least eighteen years old at the time of entry and have internet access. Begins on 10.1.16 at 12:00:00 a.m. ET and ends on 10.22.16 at 11:59:59 p.m. ET. To enter this giveaway, submit your full name and email address on this form. Odds of winning this giveaway depend on the total number of eligible entries received. Only one (1) entry per email address per day. Sponsored by Leite's Culinaria, Inc. For more information, visit our Official Rules. For a list of winners, check out our Very Happy Winners page. Be sure to add firstname.lastname@example.com to ensure notification if you are the winner.


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I saw the guy who I assisted for a few weeks at a formal. He dates this woman on and off. Anyhow I know he has a sexual thing for me, I was his hot young assistant and he loved to show me to all his male friends. But he did not tell his date that I worked alone with him. It was a very informal "job" mostly just shadowing him for fun because we hit it off. His friend told me he never told the woman for "obvious reasons".
He was chatting and flirting with me at the formal, hugged me, said I looked stunning. But when his date was around he shook my hands and acted all formal. At one point we were talking and she appeared and he suddenly pulled away.
She did not seem to like me but he and I never did anything sexual.plus she doesn't know I was close to him to my knowledge. So does she think he would have the hots for me? Because I know he does and he has said many sexual things. He probably would f*** me if he could.
Whats the deal?
Most Helpful Guy
I can't relate
Bt I can tell you one thing
If she doesn't hate you
Then she's jealous
She may not know everything
Bt women can tell
It's scary almost
Can tell that he's attracted to me? she was with her friend and he was alone and he and I were talking and he was telling me I look beautiful and flirting with me and standing close. Then she came out and he pulled away really fast
He was probably a little sweaty
Or if he wasn't she still might've seen him pull away


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The Scream! Factory on Facebook
We told you a while back that The Scream Factory would be releasing both Scanners II: The New Order and Scanners III: The Takeover on Blu-ray and DVD this fall, and now we have some artwork to dig on!
The 1991 direct-to-video sequel Scanners II: The New Order starred David Hewlett of future "Stargate" TV fame and Deborah Raffin (Death Wish 3) in a tale about a mild-mannered scanner mixed up in a government conspiracy involving evil Scanners plotting a coup. Its lesser 1992 follow-up Scanners III: The Takeover starred no one in particular and dealt with a sibling rivalry between good and evil scanners.
Hopefully one day we'll see the original flick get the Blu-ray treatment it richly deserves. Fingers crossed!
For more visit the official The Scream Factory website, and "like" The Scream Factory on Facebook.
Got news? Click here to submit it!
Plot a coup in the comments section below!


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The Hello Kitty Pen Holder is the most fashionable and efficient way to organize your desk and message area. This clever organizer features 1 large storage compartment that will easily accommodate your pens, pencils, scissors and other long office tools. This one features Hello Kitty as an artist.
●Brand New Item
●Sanrio Licensed Item
●Material: Poly
●Dimensions: aprox. 10 x 8 x 10 cm / 3.9" x 3.15" x 3.9"
Important Message
A "Recommended Age" is provided as a guideline to suggest the age range children would most likely enjoy and derive creative play value from the product. The age range is based on safety considerations in the design and contents of the product as well as a child's developmental abilities and skill level. Products which are not appropriate for your child's age group may pose safety hazards.
WARNING: CHOKING HAZARD-Small parts. Not for children under 3 years.
|Brand Logo


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Great Internet Marketing Tips It Pays Know
There are so many different facets to internet marketing, from newsletters to rotating banner ads to flash ads that take over your screen to social media. Here are some ideas that we've compiled, on a variety of internet marketing topics, which will help you diversify your strategies, but remain focused on your goals.
One internet marketing tactic you can use to maintain a relationship with customers and website visitors is to send out a newsletter via email. Make sure your newsletter is brief, informative and offers something of value. A good way to keep newsletters brief and also encourage repeat visits at your website, is to email out only summaries of newsletter content, including links to longer articles on your website.
Keep advertisements rotating on your blog with an ad rotation plug-in. By tracking clicks and earnings of individual ads, you can easily adjust to remove those that are not generating income for you. Maximizing your space with profit generating ads should be a task you perform regularly for profitable returns.Presumably, you may have learned to bypass web sites along thes lines of this article that provide awful recommendations.
Create a relationship with an online media outlet that specializes in topics that are relevant to your company. If they post a link to your site on their page, you have access to a large pool of interested users. An online media outlet is also a great place to send press releases about your business. Is there something new and exciting that you are unveiling? This lets a community of people who are already interested in your field know about what you are doing.
If you can offer free samples, do so. Nothing tells a customer that you are credible like offering the chance to try your product for free. This tells a customer that you really do have confidence in your products, and you are willing to prove that they will work for them. Samples increase the number of repeat buyers.
A great internet marketing tip is to do a little bit of research on keywords. It's important to know which keywords are popular because they have enormous potential to drive traffic to your web site. A good idea is to generate pages of content on your site for different keywords.
Brand yourself up. Make a logo, a saying, or even a simple title that will carry into everything you do. When people start to recognize your brand, success is on the way. Market your website just like you would a product: acknowledge the shortfalls, but be sure to praise the uniqueness.
Consider adding to your internet marketing plan by posting a series of online videos. This new technology allows businesses to target customers that they might not have been able to reach otherwise. You can add short videos to several popular websites for a reasonable price, and this tactic should increase traffic on your website.
Don't use the e-mail addresses of non-consenting individuals for advertising purposes. It is not only rude to fill someone's mailbox with unwanted advertising e-mails, but can also be illegal. Be sensitive to your prospective customers' needs. When they ask you to remove them from your database do it promptly or before your next e-mail campaign.
A good way of advertising in terms of internet marketing is to add catchy words to your advertisement. Using words like "fast" and focusing on phrases such as "fast ordering" or "fast results" will encourage the consumer to use the product that you are selling. A good example is to say things like "Our product works fast".
Every day, new technologies are appearing, which an internet marketer can take advantage of. Continue to read about new ideas and then, implement them into your marketing strategies and you will find great success in this career. Someone who is always bettering themselves can turn that into bettering their business, too.


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Question: Moses a self supporting minor purchased a van to carry
Moses, a self- supporting minor, purchased a van to carry on his business activities and to commute from his home to the college he attended part- time. Before reaching majority, he tried to disaffirm the purchase of the van, but the dealer refused to accept return of the van or to refund the purchase price. Can Moses require the dealer to take back the van and return the purchase price?
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Answer to relevant QuestionsConnor, age 17, moved away from home. She rented a room in a nearby town and orally agreed to pay the landlady $ 160 a month for six months. Connor paid rent for three months and then moved out without paying the remaining ...Husband, who was suffering from schizophrenia and manic depression, had been in and out of a mental hospital, but at no time had he been declared insane by a court. In fact, he continued to work at his job as a design ...Karns leases his small private plane to others interested in recreational flying. One Sunday morning, Ashbery rented the plane for the day. Karns was unaware that Ashbery rented the plane to haul illegal drugs from one ...In the state of Hawaii, a person must meet certain educational requirements and pass a written exam to be granted a license to practice architecture. Once the initial license is received, an annual license fee is required to ...The Roc Co. entered into an oral contract to pay Willis and Associates, a certified public accounting firm, $ 35,000 to perform a complete audit of its accounting records. The report was to cover a period of ten months but ...
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Question: Every year the Bureau of Labor Statistics administers a survey
Every year, the Bureau of Labor Statistics administers a survey of American households called the American Time Use Survey. Respondents are asked to report their activities during an entire 24-hour day. The results are used to determine the number of hours respondents work in a typical week. The results for government and private-sector workers were recorded. Is there sufficient evidence to infer that government employees work less than private-sector workers?
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View Solution:
Answer to relevant QuestionsHow important to your health are regular vacations? In a study a random sample of men and women were asked how frequently they take vacations. The men and women were divided into two groups each. The members of group 1 had ...In designing advertising campaigns to sell magazines, it is important to know how much time each of a number of demographic groups spends reading magazines. In a preliminary study, 40 people were randomly selected. Each was ...Clinical depression is linked to several other diseases. Scientists at Johns Hopkins University undertook a study to determine whether heart disease is one of these. A group of 1190 male medical students was tracked over a ...Many small retailers advertise in their neighborhoods by sending out flyers. People deliver these to homes and are paid according to the number of flyers delivered. Each deliverer is given several streets whose homes become ...At a camp cafeteria teenagers were randomly given a tall skinny glass or a short wide glass. As they proceeded through the line they loaded up on the food they wanted and poured whatever drink they chose. At the end of the ...
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The Use of Pearlescent Pastels
painting by artist Karen Margulis
16 in X 12 in (40.6 cm X 30.5 cm)
This painting is available through an online store or blog page.
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Images may not be reproduced without the permission of the artist.


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Puritanism in the Old World and in the New, from Its Inception in the Reign of Elizabeth to the Establishment of the Puritan Theocracy in New England: A Historical Handbook
Fleming H. Revell Company, 1896 - Puritans - 406 pages
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Page 254 - And John answered and said, Master, we saw one casting out devils in thy name ; and we forbade him, because he followeth not with us. 50 And Jesus said unto him, Forbid him not : for he that is not against us is for us.
Page 375 - For before that certain came from James, he did eat with the Gentiles ; but when they were come, he withdrew and separated himself, fearing them which were of the circumcision. And the other Jews dissembled likewise with him ; insomuch that Barnabas also was carried away with their dissimulation.
Page 258 - To the end the body of the commons may be preserved of honest and good men, it was ordered and agreed, that, for the time to come, no man shall be admitted to the freedom of this body politic, but such as are members of some of the churches within the limits of the same.
Page 188 - And they shall be mine, saith the Lord of hosts, in that day when I make up my jewels ; and I will spare them, as a man spareth his own son that serveth him. Then shall ye return, and discern between the righteous and the wicked : between him that serveth God, and him that serveth him not.
Page 236 - Covenant and combine ourselves together into a Civil body politic, for our better ordering and preservation, and furtherance of the ends aforesaid ; and by virtue hereof, to enact, constitute, and frame such just and equal laws, ordinances, acts, constitutions, and offices, from time to time, as shall be thought most meet and convenient for the general good of the colony, unto which we promise all due submission and obedience.
Page 236 - Faith, etc., having undertaken, for the glory of God and advancement of the Christian faith, and honor of our King and country, a voyage to plant the first colony in the northern parts of Virginia...
Page 288 - And well knowing where a people are gathered togather the word of God requires that to mayntayne the peace and union of such a people there should be an orderly and decent Government established according to God...
Page 378 - And though all the winds of doctrine were let loose to play upon the earth, so Truth be in the field, we do injuriously, by licensing and prohibiting, to misdoubt her strength. Let her and Falsehood grapple; who ever knew Truth put to the worse, in a free and open encounter?
Page 237 - Being thus arrived in a good harbor, and brought safe to land, they fell upon their knees and blessed the God of Heaven who had brought them over the vast and furious ocean, and delivered them from all the perils and miseries thereof, again to set their feet on the firm and stable earth, their proper element.
Page 300 - IN THE NAME OF GOD, AMEN. We whose names are underwritten, the loyal subjects of our dread sovereign lord King James, by the grace of God of Great Britain, France, and Ireland, king, defender of the faith, etc.


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BU Jhansi Date Sheet 2017, Bundelkhand University Time table, BU Jhansi Exam Scheme, BA, BSC, BCOM Schedule, Bundelkhand University Exam Routine,
Bundelkhand University Time Table 2017
Hello Dear Friends, here is good news for all the candidates who are looking the Bundelkhand Univerity Exam Time Table 2017. The Bundelkhand University is go to release BU Jhansi Exam Schedule 2017 as soon in the month of January? Feb. The Bundelkhand University conduct the UG & PG Courses Examination like as BA, BSC, BCOM, MA, MSC, MCOM etc. in the month of March & April. This year also be conducted examination mostlt similar to previous year exams. Those candidates have been apply to appear in BU Jhansi UG & PG Examination Form Session 2016-17. They can download their Bundelkhand University UG and PG Exam Schedule 2017 through official web site or given below link. If any more details about BU Jhansi Date Sheet 2017, you may visit official web site @bujhansi.org.
BU Jhansi BA/BSC/BCOM Date Sheet 2017
A large number of candidates have been appear in the Bundelkhand University in UG Courses like as BA, BSC, and BCOM. Now this time all the candidates are require the Exam date sheet for the Examination. The Bundelkhand University not announces the Exam time table yet but university shortly declare BU Jhansi Exam Date Sheet on the official web site. We will update here Bundelkhand University Exam Scheme 2017 as soon. So we are requested all the candidates please keep patience, candidates can check regularly our same web page after announce official web site. they can start their Exam Preparation.
BU Jhansi UG PG Exam Date Sheet 2017:-
Bundelkhand University, Jhansi will go to conduct the yearly examination for applicants of regular and private category enroll for this session. BU Jhansi Exam authority will be announce the Exam Date sheet and schedule soon. Students can check all the details here on this page. We will provide the BU Jhansi BA / BCOM / BSC Exam Date Sheet 2017 after provide by the University.
Bundelkhand University Exam Schedule 2017
- Name of Department: Bundelkhand University Jhansi
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- Date of Exam : January
- Category : Date Sheet 2017
- Status : Update Soon
- Time Table issue Date : October 2017
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All the candidates are informed that who are going to applied for the UG (Under Graduate) and PG (Post Graduate) Examination; they can download their BU Jhansi Exam Programme 2017 through official web site. Here we are write some simple instruction and Link as given below. It is a very help full for the candidates downloading time you can follow it and simply access the date sheet.
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BU Jhansi Exam Scheme 2017
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This hotel comprises a total of 81 rooms spread over 4 floors. Facilities on offer to guests at this air-conditioned establishment include a lobby area with a 24-hour reception, a hotel safe, a cloakroom and lift access. There is a bar and a restaurant and guests will appreciate the conference facilities and wireless Internet access. They can also take advantage of the room, dry cleaning and laundry services. The onsite self-parking is complimentary.
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All rooms come with a private bathroom with a bathtub and a hairdryer and offer a king-size bed. They are equipped with a direct dial telephone, a fax machine, satellite/cable TV and complimentary high-speed Internet access via the TV set, complimentary newspapers, a radio and a safe. Furthermore, tea and coffee making facilities, an ironing set and individually regulated air conditioning and heating are provided in all accommodation units as standard.
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Guests arriving on US 31 North or South should exit at Sternberg Road and go east toward Harvey Road. Turn left onto Harvey Road and continue past Lakeshore Marketplace. Turn left onto Ellis Road. Those coming from the I-96 should take exit 1A to US 31 South then exit at Sternberg Road heading east. Turn left and drive to Harvey Road. Turn left then go past Lakeshore Marketplace and turn left again onto Ellis Road. From Muskegon County Airport, turn left out of airport onto Ellis Road. At the first light turn right onto Grand Haven Road, go to Sternberg Road and turn left. Go approximately 500 m to Harvey Road and turn left. Drive past Lakeshore Marketplace and turn left onto Ellis Road.
Room Facilities:
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Dear colleagues and friends,
We had a very successful conference in Glasgow where we had inspiring and stimulating discussions on making knowledge work!
Our well attended plenaries on a wide range of relevant and timely topics enriched our understanding of management. Many thanks to Peter McKiernan for putting together these thought-provoking plenaries!
More than 1000 participants attended our 17th annual conference. The conference offering was extensive with 63 tracks, 11 symposia, 2 plenaries, 1 Strathclyde showcase event and 3 Labs. For the Doctoral Colloquium, we welcomed 39 participants. We are grateful to our 16 speakers, 17 mentors, DC co-chairs who voluntarily contributed to this wonderful event.


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About Our Residential Construction Company
Over 30 Years Serving the Ridgefield & Westport, CT Areas
JC Merritt, Inc. was founded over 30 years ago in Northwest Connecticut by Jeff Merritt. Still family-owned to this day, Jeff and his crew specialize in foundation and structural repair, but deliver all size projects across Fairfield and Litchfield counties. We have the knowledge and expertise to take on jobs from small repairs up to contracting additional crews and consulting experts for complicated projects.
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By helping companies holistically integrate strategy across these four areas with their own unique and tailored collaboration and execution model, EQUIBT enables clients to deliver products, services, and customer experiences that accelerate innovation, organisational growth, and performance improvement.


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Fluid flow phenomena
Fluid flow phenomena. A numerical toolkit. Incl. 1 disk. The main topic of the book is the simulations of one-, two- and three-dimensional incompressible Navier-Stokes equations in laminar and turbulent regimes. The author describes concrete links between theory and practice, offering a large number of codes which allow to handle the Navier-Stokes equations and to understand the complex physics related to fluid mechanics. A large part of the book is devoted to the study of homogeneous and wall turbulent flows. The book includes large eddy simulation methodology since in the near future it will allow to treat universal turbulence models sufficient for practical applications. The finite difference method is used to solve parabolic and elliptic partial differential equations in Cartesian and cylindrical coordinates The direct numerical simulations of Navier-Stokes equations reproduce satisfactorily the dynamics of turbulent flows. The results for turbulent and laminar flows are discussed with particular emphasis on vortex dynamics.par A well-balanced mix between the theory and the wide range of applications makes this volume of great interest to all practitioners of computational fluid dynamics: engineers, researches, teachers and graduate students.
Keywords for this software
References in zbMATH (referenced in 24 articles , 1 standard article )
Showing results 1 to 20 of 24.
- Bai, Zhong-Zhi; Ran, Yu-Hong; Yuan, Li: On approximated ILU and UGS preconditioning methods for linearized discretized steady incompressible Navier-Stokes equations (2014)
- Lenaers, Peter; Schlatter, Philipp; Brethouwer, Geert; Johansson, Arne V.: A new high-order method for the simulation of incompressible wall-bounded turbulent flows (2014)
- van Yen, Romain Nguyen; Kolomenskiy, Dmitry; Schneider, Kai: Approximation of the Laplace and Stokes operators with Dirichlet boundary conditions through volume penalization: a spectral viewpoint (2014)
- Nguyen van yen, Romain; Farge, Marie; Schneider, Kai: Scale-wise coherent vorticity extraction for conditional statistical modeling of homogeneous isotropic two-dimensional turbulence (2012)
- Nygård, Frode; Andersson, Helge I.: On pragmatic parallelization of a serial Navier-Stokes solver in cylindrical coordinates (2012)
- Araya, Guillermo; Leonardi, Stefano; Castillo, Luciano: Steady and time-periodic blowing/suction perturbations in a turbulent channel flow (2011)
- Borello, Domenico; Orlandi, Paolo: DNS scrutiny of the $\zeta$-$f$ elliptic-relaxation eddy-viscosity model in channel flows with a moving wall (2011)
- Dritselis, C.D.; Vlachos, N.S.: Effect of magnetic field on near-wall coherent structures and heat transfer in magnetohydrodynamic turbulent channel flow of low Prandtl number fluids (2011)
- Nygård, F.; Andersson, H.I.: Numerical investigations of laminar flow characteristics in helically finned pipes (2011)
- Pirozzoli, Sergio: Stabilized non-dissipative approximations of Euler equations in generalized curvilinear coordinates (2011)
- Seddighi, Mehdi; He, Shuisheng; Orlandi, Paolo; Vardy, Alan E.: A comparative study of turbulence in ramp-up and ramp-down unsteady flows (2011)
- Danaila, Ionut; Hecht, Frédéric: A finite element method with mesh adaptivity for computing vortex states in fast-rotating Bose-Einstein condensates (2010)
- Pirozzoli, Sergio: Generalized conservative approximations of split convective derivative operators (2010)
- Shah, Abdullah; Yuan, Li; Khan, Aftab: Upwind compact finite difference scheme for time-accurate solution of the incompressible Navier-Stokes equations (2010)
- Danaila, Ionut; Vadean, Claudiu; Danaila, Sterian: Specified discharge velocity models for numerical simulations of laminar vortex rings (2009)
- Kakarantzas, S.C.; Sarris, I.E.; Grecos, A.P.; Vlachos, N.S.: Magnetohydrodynamic natural convection in a vertical cylindrical cavity with sinusoidal upper wall temperature (2009)
- Laizet, Sylvain; Lamballais, Eric: High-order compact schemes for incompressible flows: a simple and efficient method with quasi-spectral accuracy (2009)
- Xu, Hui; Tao, Wenquan; Zhang, Yan: Lattice Boltzmann model for three-dimensional decaying homogeneous isotropic turbulence (2009)
- Araya, Guillermo; Leonardi, Stefano; Castillo, Luciano: Passive scalar statistics in a turbulent channel with local time-periodic blowing/suction at walls (2008)
- Duponcheel, M.; Orlandi, P.; Winckelmans, G.: Time-reversibility of the Euler equations as a benchmark for energy conserving schemes (2008)


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Learning generative models of molecular dynamics
Selected articles from the Tenth Asia Pacific Bioinformatics Conference (APBC 2012)
The Tenth Asia Pacific Bioinformatics Conference (APBC 2012)
We introduce three algorithms for learning generative models of molecular structures from molecular dynamics simulations. The first algorithm learns a Bayesian-optimal undirected probabilistic model over user-specified covariates (e.g., fluctuations, distances, angles, etc).
The three dimensional structures of proteins and other molecules vary in time according to the laws of thermodynamics. Each molecule visits an ensemble of states which can be partitioned into distinct
Molecular dynamics (MD) simulations are often used to characterize conformational dynamics
Our approach to analyzing MD data is to learn generative models known as Markov Random Fields (MRF). This is the first time MRFs have been used to model MD data. A MRF is an undirected probabilistic graphical model that encodes the joint probability distribution over a set of user-specified variables. In this paper those variables correspond to the positional fluctuations of the atoms, but the technique can be easily extended to other quantities, such as pairwise distances or angles. The generative nature of the model means that new conformations can be sampled and, perhaps more importantly, that users can make structural alterations to one part of the model (e.g., modeling the binding of a ligand) and then perform inference to predict how the rest of the system will respond.
We present three closely related algorithms. The first algorithm learns a single model from the data. Both the topology and the parameters of the model are learned. The topology of the learnt graph reveals which variables are directly coupled and which correlations are indirect. Alternative methods, such as constructing a covariance matrix cannot distinguish between direct and indirect correlations. Our algorithm is guaranteed to produce an optimal model. Regularization is used to reduce the tendency of over-fitting the data. The second algorithm learns a time-varying model where the topology and parameters of the MRF change smoothly over time. Time-varying models reveal the different conformational sub-states visited by the molecule and the features of the the energy barriers that separate them. The final algorithm learns a Markov Chain over MRFs which can be used to generate new trajectories and study to kinetics.
Molecular dynamics simulation
Molecular Dynamics simulations involve integrating Newton's laws of motion for a set of atoms. Briefly, given a set of
Traditional methods for analyzing MD data either monitor the dynamics of global statistics (e.g., the radius of gyration, total energy, etc), or else identify sub-states via a clustering the frames
More recently, Lange and Grubmüller introduced full correlation analysis
Markov Random Fields
A Markov Random Field
Gaussian Graphical Models
Gaussian distributions have a number of desirable properties including the availability of analytic expressions for a variety of quantities. For example, the probability of observing
or the KL-divergence between two different models:
A GGM can also be used to manipulate a subset of variables and then then compute the marginal densities for the remaining variables. For example, let V ⊂ X be an arbitrary subset of variables X and let W be the complement set. We can condition the model by setting variables V to some particular value,
We now present three algorithms for learning various kinds of generative models from MD data.
Input The input to all three algorithms is a time-series of vectors
Algorithm 1
Output The first algorithm produces a Gaussian Graphical Model
The algorithm produces the sparsest precision matrix that still fits the data (see below). It also guarantees that Σ-1 is positive-definite, which means it can be inverted to produce the regularized covariance matrix (as opposed to the sample covariance, which is trivial to compute). This is important because Eqs 1-3 require the covariance matrix, Σ. We further note that a sparse precision matrix does not imply that the corresponding covariance matrix is sparse, nor does a sparse covariance imply that the corresponding precision matrix is sparse. That is, our algorithm isn't equivalent to simply thresholding the sample covariance matrix, and then inverting.
Learning regularized precision matrices
A straight-forward way of learning a GGM is to find the parameters (
Our algorithm addresses the problem of over-fitting by maximizing the following objective function:
Here, ||Σ-1||1 is the
Algorithmically, our algorithm maximizes Eq. 6 in an indirect fashion, by defining and then solving a convex optimization problem. Using the functional form of
Noting that
Next, using the definition of the sample covariance matrix,
we can define the matrix Σ-1 that maximizes 6 as the solution to the following optimization problem:
We note that
We now show that the optimization problem defined in Eq. 7 is smooth and convex and can therefore be solved optimally. First, we consider the dual form of the objective. To obtain the dual, we first rewrite the
where ||U||∞ denotes the maximum absolute value element of the matrix U. Given this change of formulation, the primal form of the optimization problem can be rewritten as:
That is, the optimal Σ-1 is the one that maximizes the worst case log likelihood over all additive perturbations of the covariance matrix.
Next, we exchange the
such that Σ-1 = (S + U*)-1.
After one last change of variables, W = S + U, the dual form of Eq. 7 can now be defined as:
Eq. 9 is smooth and convex, and for small values of
Block Coordinate Descent
Given matrix A, let A\
Algorithm 1 Block Coordinate Descent
Require: Tolerance parameter ε, sample covariance S, and regularization parameter λ.
Initialize W(0):= S + λI where I is the identity matrix.
Set W(
end for
Set W(0) = W(
return W(0)
The time complexity of this algorithm is
In summary, the algorithm produces a time-averaged model of the data by computing the sample mean and then constructing the optimal regularized Σ by solving Eq. 9 using Block Coordinate Decent. The regularized covariance matrix Σ is guaranteed to be invertible which means we can always compute the precision matrix, Σ-1, which can be interpreted as a graph over the variables revealing the direct and indirect correlations between the variables.
Algorithm 2
The second algorithm is a straight-forward extension of the first. Instead of producing a time-averaged model, it produced time-varying model:
Let D(
Here, S(
Algorithm 3
The final algorithm builds on the second algorithm. Recall that the second algorithm learns
We applied our algorithms to several molecular dynamics simulation trajectories. In this section, we illustrate some of the results obtained through this analysis. The algorithms were implemented in Matlab and run on a dual core T9600 Intel processor running at 2.8 Ghz. The wall-clock runtimes for all the experiments were on the order of seconds to about 10 minutes, depending on the size of the data set and parameter settings.
Algorithm 1: application to the early events of HIV entry
We applied the first algorithm to simulations of a complex (Figure
Figure 1
(Left) gp120 (blue) bound to CD4 (green)
(Left) gp120 (blue) bound to CD4 (green). (Right) The same complex bound to Ibalizumab (yellow and purple), a monoclonal antibody HIV entry inhibitor. Notice that Ibalizumab does not bind to gp120.
Ibalizumab's mechanism of action is poorly understood. As can be seen in Figure
Correlation networks
Figure 2
gp120-CD4 correlation networks learned with Algorithm 1
gp120-CD4 correlation networks learned with Algorithm 1. (Left) Edges learned by algorithm for the drug-free simulation. (Right) Edges learned by algorithm for the drug-bound simulation.
The probabilistic nature of the model means that it is possible to compute the likelihood of each data set under both models. Table
Table 1
Figure 3
gp120-CD4-Ibalizumab correlation networks learned with Algorithm 1
gp120-CD4-Ibalizumab correlation networks learned with Algorithm 1. Edges learned by algorithm for the drug-bound simulation. Here, all three models are shown.
Comparison to sub-optimal models
Our method is guaranteed to return an optimal model. Here we compare the models returned by our algorithm to those obtained by a reasonable, but nevertheless sub-optimal algorithm for generating sparse networks. For comparison, we inverted the
Figure 4
Thresholded precision matrix models
Thresholded precision matrix models. (Left) Edges produced by thresholding inverse of sample covariance matrix for the drug-free simulation. (Right) Edges produced by thresholding inverse of sample covariance matrix for the drug-bound simulation. Notice that the edges lack the kind of structure seen in Figures
Perturbation analysis
Next, we demonstrate the use of inference to quantify the sensitivity of gp120 to structural perturbations in the drug. We conditioned the model learned from the trajectory with gp120, CD4 and Ibalizumab on the structure of the drug and then performed inference (Eq. 4) to compute the most likely configuration of remaining variables (i.e., those corresponding to gp120 and CD4). This was repeated for each frame in the trajectory. The residues with the highest average displacement are illustrated as red spheres in Figure
Figure 5
Sensitivity to perturbations
Sensitivity to perturbations. The red spheres mark the residues that are most sensitive to perturbations in the drug.
Algorithm 2: application to a 1 microsecond simulation of the engrailed homeodomain
We applied the second algorithm to a simulation of the engrailed homeodomain (Figure
Figure 6
Engrailed homeodomain
Engrailed homeodomain.
We performed three 50-microsecond simulations of the protein at 300, 330, and 350 degrees Kelvin. These simulations were performed on A
Figure 7
(A) Differential entropy of the 500 model learned from the engrailed trajectory
(A) Differential entropy of the 500 model learned from the engrailed trajectory. (B) Correlation network of the model with the smallest differential entropy (model 42). (C) Correlation network of the model with the largest differential entropy (model 342).
Figure 8
(A) Average log-likelihood of the frames from the
(A) Average log-likelihood of the frames from the
Figure 9
(A) KL-divergence between sequential models
(A) KL-divergence between sequential models. (B) Pairwise KL-divergences between models.
Algorithm 3: application to a 1 microsecond simulation of the engrailed homeodomain
Using the 500 models learned in the previous section, we computed the symmetric KL-divergence between all pairs of models. Recall that the KL-divergence (Eq. 3) is a measure of the difference between distributions. Figure
We then applied complete linkage clustering to the KL-divergence matrix. Complete linkage clustering minimizes the maximum distance between elements when merging clusters. We selected a total of 7 clusters based on the assumption that the number of sub-states visited by a sequence of
Figure 10
Representative structures for states 4 (green) and 6 (magenta)
Representative structures for states 4 (green) and 6 (magenta).
Finally, we estimated the parameters of a Markov chain over the 7 clusters by counting the number of times a model from the
Figure 11
State-transition matrix
State-transition matrix. The color indicates the log of the number of times state
Many existing techniques for analyzing MD data are closely related to, or direct applications of Principal Components Analysis (PCA). Quasi-Harmonic Analysis (QHA)
PCA-based methods generally project the data onto a low-dimensional subspace spanned by the eigenvectors corresponding to the largest eigenvalues. This is done to simplify the data and because lower dimensional models tend to be more robust (i.e., less likely to over-fit the data). Our methods, in contrast, uses regularization when estimating the parameters of the model to achieve the same goals.
The eigenvectors produced by PCA-based methods contain useful information about how different regions of the system move in a coordinated fashion. In particular, the components of each vector quantify the degree of coupling between the covariates in that mode. However, the eigenvectors make no distinction between direct and indirect couplings. Moreover, eigenvectors are an inherently global description of dynamics. Our methods, in contrast, do not perform a change of basis and instead models the data in terms of a network of correlations. The resulting model, therefore, reveals which correlations are direct and which are indirect. Pathways in these networks may provide mechanistic insights into important phenomena, such as allosteric regulation. Our models can also be used to investigate motions that are localized to specific regions of the system.
Finally, we note that because our first algorithm produces a regularized estimate of the true covariance matrix, Σ, it could potentially be used as a pre-processing step for PCA-based methods, which normally take as input the sample covariance matrix.
Conclusions and future work
We have introduced three novel methods for analyzing Molecular Dynamics simulation data. Our algorithms learn regularized graphical models of the data which can then be used to: (i) investigate the networks of correlations in the data; (ii) sample novel configurations; or (iii) perform
There are a number of important areas for future research. Gaussian Graphical Models have a number of limitations, most notably that they encode uni-modal distributions and are best suited to modeling harmonic motions. Boltzmann distributions, in contrast, are usually multi-modal. Our third algorithm partially addresses this problem by creating a Markov chain over GGMs but the motions are still harmonic. Discrete distributions could be used to model anharmonic motions (e.g., by adapting the algorithm in
List of abbreviations used
GGM: Gaussian Graphical Model; KL: Kullback Leibler; MAP: maximum a posteriori; MD: Molecular dynamics; MRF: Markov Random Field; MSM: Markov State Model; PCA: Principal Components Analysis; QHA: Quasi-Harmonic Analysis.
Competing interests
The authors declare that they have no competing interests.
Authors' contributions
All three authors contributed to the creation and implementation of the algorithms and writing the manuscript. N.S.R. and C.J.L. performed the experiments and analysis.
This work is supported in part by US NSF grant IIS-0905193. Use of the Anton machine was provided through an allocation from National Resource for Biomedical Supercomputing at the Pittsburgh Supercomputing Center via US NIH RC2GM093307.
This article has been published as part of
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Full correlation analysis of conformational protein dynamics
Learning generative models for protein fold families
The von Mises graphical model: regularized structure and parameter learning
Progress and challenges in the automated construction of Markov state models for full protein systems
Model selection through sparse maximum likelihood estimation for multivariate Gaussian or binary data
Determinant maximization with linear matrix inequality constraints
Free energy estimates of all-atom protein structures using generalized belief propagation
Accounting for conforma-tional entropy in predicting bidning free energies of protein-protein interactions
Scalable molecular dynamics with NAMD
Safety, pharmacokinetics, and antiretroviral activity of multiple doses of ibalizumab (formerly TNX-355), an anti-CD4 monoclonal antibody, in human immunodeficiency virus type 1-infected adults
Loss of asparagine-linked glycosylation sites in variable region 5 of human immunodeficiency virus type 1 envelope is associated with resistance to CD4 antibody ibalizumab
Homeodomain proteins
Missense mutations of human homeoboxes: a review
Homeodomain-DNA recognition
The denatured state of engrailed homeodomain under denaturing and native conditions
Protein folding and unfolding in microseconds to nanoseconds by experiment and simulation


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Forbidden Broadway's Greatest HitsMAY 30 – JUNE 2 | GAEDE STAGE | MUSICAL/PGIn this long-running Off-Broadway hit musical revue, Broadway's greatest musical legends meet Broadway's greatest satirist in this hilarious, loving, and endlessly entertaining tribute to some of the theatre's greatest stars and songwriters. It's Annie, Phantom of the Opera, Cats, Les Miserables, and many more rolled into one theatrical valentine.
Church Basement Ladies 2: A Second HelpingJUNE 6 – 9 | HANSEN THEATRE | MUSICAL/PGThe show takes us from serving the High School students at the Luther League Banquet to a church sponsored Missionary Night and the rise and fall of a Viking's Super Bowl Sunday. From the elderly matriarch of the kitchen to the young mom-to-be, these women find strength in each other as they deal with the joys and upheavals from below the "House of God!"
The Glass MenagarieJUNE 13 – 16 | GAEDE STAGE | DRAMA/PGTennessee Williams achieved his first major success with this autobiographical "memory play," which looks at the Wingfield family — frustrated writer Tom, his nagging mother, Amanda, who is often lost in memories of her Southern-belle past, and his painfully shy sister, Laura — and the effect a visit from a "gentleman caller" for Laura has on all their lives. Purchase tickets online today!
Hello, Dolly!JUNE 20 – 23 | HANSEN THEATRE | MUSICAL/PGHello, Dolly! the blockbuster Broadway hit, bursts with humor, romance, high-energy dancing, and some of the greatest songs in musical theater history. The romantic and comic exploits of Dolly Gallagher-Levi, turn-of-the-century matchmaker and "woman who arranges things," are certain to thrill and entertain audiences again and again. Purchase tickets online today!


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Author: Jennifer Forman Orth
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Not sure why Canada has grabbed a hold of this news bit, but The Canoe Network, among other Canadian sources, is reporting that Puerto Rico's Department of Natural and Environmental Resources is considering drastic measures to deal with the green iguanas (Iguana iguana) at the island's airport. Seems the introduced iguanas love to lay out on the runways, soaking up all the nice heat the tarmac absorbs from the sun. Things have gotten bad enough that flights have been delayed, causing the government to consider several eradication measures, including shooting the lizards "with .22-calibre rifles." Not sure why they were so specific about that - sounds like it was one weird press conference.
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Dr. Marc Reiskind MD
- Physical Medicine and Rehabilitation Clearwater, FL
Patient Reviews
Reviews reflect patients' level of satisfaction with the care they received from this provider. Dr. Marc Reiskind xhas an overall rating of 3.5.
Dr. Marc Reiskind, MD is a Doctor primarily located in Clearwater, FL. He has 28 years of experience. His specialties include Physical Medicine and Rehabilitation. Dr. Reiskind is affiliated with Bayfront Health St Petersburg, All Children's Hospital and St Anthony's Hospital. He speaks English.
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Specialties & Expertise
Dr. Marc Reiskind has the following 11 areas of expertise, 1 specialty and 2 board certifications.
Physical Medicine and Rehabilitation
A physiatrist is a doctor who specializes in the rehabilitation and physiological treatment of patients with an illness or injury that affects movement.
These specialists have extensive knowledge of the nerves, muscles, bone, and brain. Physiatrists are also experts in pain medication.
Some common conditions that physiatrists treat are rheumatoid arthritis, neurological and spinal disorders and injuries, chronic pain disorders, like fibromyalgia, and musculoskeletal issues, like broken bones and torn muscles.
These physicians also often coordinate a team of other specialists in order to maximize the patient's recovery, such as occupational therapists, speech therapists, neurologists, orthopedists, and counselors.
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