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2017 Jaguar XE
COURTESY VEHICLE Sedan
2017 Jaguar XE
COURTESY VEHICLE Sedan
|Used Clear Title
|8 Spd Automatic
|Rear Wheel Drive
|Exterior Color
|Rhodium Silver Metallic
|Oyster/Light Oyster Leather
|Stock #
|Balance of Factory Warranty
Vehicle OverviewSilver Bullet! Turbocharged! Handpicked from our new car inventory and meticulously maintained for our customers! Why buy one of our courtesy vehicles? Land Rover North Scottsdale's courtesy vehicles are priced to sell! Courtesy vehicles qualify for new car rates & customer incentives and include the remainder of the Land Rover new car warranty and maintenance programs. Our courtesy vehicles start out as brand new current model year Land Rovers and typically have less than 25,000 miles and occasionally very few miles. Please be patient as this specific vehicle may be out with a client and may not be available for immediate delivery. Please note that the mileage will vary from the mileage listed above as the courtesy vehicle mileages are not updated daily. If you've been aching for just the right 2017 Jaguar XE, then stop your search right here. This is the ideal car that is sure to fit your needs. Climb into this terrific Jaguar XE, knowing that it will always get you where you need to go, on time, every time.
Financing Information
Contact us today at 480-538-4300 for more information, or fill out our Online Credit Application to begin the pre-approval process today.
Warranty InformationThis Vehicle is Covered by the Original Factory Warranty. Contact us for more information on the full balance of factory warranty.
If you are interested in one of our vehicles and have a question on available warranties, please contact us!
Contact Us at 480-538-4300
Land Rover North Scottsdale18100 North Scottsdale Road, Phoenix, Arizona 85054
Call Us About This Vehicle: 480-538-4300
- Rhodium Silver Metallic with Oyster/Light Oyster Leather Interior
- Air Conditioning
- Climate Control System
- Cruise Control
- Dual Zone Electronic Climate Control System
- Heated Mirrors
- Leather Steering Wheel
- Moonroof
- Remote Trunk Lid
- Steering Wheel Radio Controls
- Telescoping Steering Wheel
- Tire Pressure Monitor
- Power Driver's Seat
- Power Mirrors
- Power Passenger Seat
- Power Steering
- Child Proof Door Locks
- Daytime Running Lights
- Driver's Air Bag
- Intermittent Wipers
- Passenger Air Bag
- Rear Defogger
- Roll Stability Control
- Security System
- Side Air Bags
- Side Curtain Airbags
- Carpeted Floor Mats
- Center Arm Rest
- Clock
- Overhead Console
- Tachometer
- Vanity Mirrors
- Remote Fuel Door
- Sunroof
- Aux. Audio Input
- Bluetooth
- Factory System
- HD Radio
- HD Radio
- Premium Sound
- Touch Screen
Advertised service loaners may not be immediately available for demonstration or delivery. See dealer to schedule an appointment.
All advertised prices exclude government fees and taxes, any finance charges, any dealer document processing charge, any electronic filing charge, and any emission testing charge.
All advertised prices expire at midnight on the day of posting.


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The Americans with Disabilities Act (ADA)
ADA requirements are outlined in The Americans with Disabilities Act (ADA), which prohibits discrimination and ensures equal opportunity for persons with disabilities in employment, state and local government services, public accommodations, commercial facilities, and transportation. It also mandates the establishment of TDD/telephone relay services.
Title II
ADA requirements are outlined in Title II of the Americans with Disabilities Act, which apply to all activities of state and local governments, regardless of an entity's size or receipt of federal funding. It requires that all state and local governments give people with disabilities an equal opportunity to benefit from all programs, services, and activities, such as public education, employment, transportation, recreation, healthcare, social services, town meetings, etc. They are required to be able to communicate effectively with people who have hearing, vision, or speech disabilities.
Title III
ADA requirements are outlined in Title III of the Americans with Disabilities Act, which prohibits discrimination on the basis of disability in "places of public accommodation" (businesses and non-profit agencies that serve the public) and "commercial facilities" (other businesses).
Read the Title III highlights from the U.S. Department of Justice
The Individuals with Disabilities Education Act (IDEA)
The Individuals with Disabilities Education Act (IDEA), and the Americans with Disabilities Act (ADA) , applies to people of all ages with learning disabilities; offering protection against discrimination and giving them a right to different forms of assistance in the classroom and workplace.
Telecommunications Act (Section 255)
Section 255 of the Telecommunications Act of 1996 requires manufacturers of telecommunications equipment and providers of telecommunications services to ensure that such equipment and services are accessible to persons with disabilities, if readily achievable. The Federal Communications Commission's Report and Order Implementing Section 255 was released in September 1999.
Section 508
ADA requirements within Section 508 have the net effect of requiring that vendors seeking to do business with the U.S. Federal Government must also ensure their websites and software tools meet accessibility requirements. While Section 508 compliance requirements stop short of placing an obligation on the operators of private sector websites, it is the buying power of the federal government that makes many private companies decide to comply with the terms of 508 - because compliance may help them to win federal work.
The World Wide Web Consortium (W3C), is the industry recognized body for setting standards for making websites usable by people of all abilities and disabilities to ensure that all users can have equal access to information and functionality through the Web Accessibility Initiative (WAI). An accessible website is achieved when web pages and processes are validated for compliance against the W3C's Standards (WCAG 2.0 level AA).
Twenty-First Century Communications and Video Accessibility Act of 2010
The Twenty-First Century Communications and Video Accessibility Act is established to ensure all individuals have equal access to new age technologies. Title I: Communication Access addresses communications access to make products and services using Broadband fully accessible to people with disabilities. For example, smartphones will be required to be usable by blind and visually impaired people as well as people with hearing aids. Title II: Video Programming of the accessibility act breaks new ground to make it easier for people with disabilities to view video programming on television and the Internet.
Food and Drug Administration Safety and Innovation Act (FDASIA)
A provision of the Food and Drug Administration Safety and Innovation Act (FDASIA) Section 904, requires access to information on prescription drug labels for individuals who are blind or visually impaired or who are elderly along with the development of best practices for making information on prescription drug container labels accessible.
Section 1557 of the Affordable Care Act (ACA)
Section 1557 is the nondiscrimination provision of the Affordable Care Act (ACA). The law prohibits discrimination on the basis of disability, age, national origin, colour and race within federally funded healthcare programs and extends protections to individuals who purchase health insurance through the health insurance marketplaces. By first plan year beginning on Jan. 1, 2017, Covered Entities must ensure applicable health insurance & group benefit designs comply with Section 1557, which includes providing appropriate auxiliary aids & services, such as alternate formats.

subset: commoncrawl


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AUSTRAC can offer you a wide range of employment benefits including:
- an attractive salary including access to annual performance-linked salary progression
- choice of superannuation fund and generous rate of employer contribution for eligible employees
- access to salary sacrificing arrangements
- flexibility to negotiate working hours
- flex time arrangements for APS 1-6 classified employees
- time off in lieu (TOIL) for Executive Level classified employees
- access to flexible work arrangements such as part-time work, job share, home based work, and purchased leave
- 20 days annual leave per year, including access to half pay
- 18 days personal/carer's leave per year to use for personal illness, caring responsibilities and emergencies
- three days compassionate leave and three days bereavement leave per occasion
- 16 weeks maternity, adoption and foster leave for eligible employees
- four weeks maternity leave for those not eligible to receive the 12 weeks maternity leave under the Maternity Leave (Commonwealth Employees) Act 1973.
- two weeks supporting partner leave
- up to 24 months unpaid parental leave
- recognition that an employee's ability to perform in their job is a major contributor to career satisfaction. In addition to meeting operational requirements, AUSTRAC's learning and development program, aims to build an employee's capability to perform their job, to work effectively with others, and to progress their Australian Public Service (APS) career
- a generous studies assistance scheme to support employees undertaking additional studies with up to 120 hours paid study leave and up to $4,000 reimbursement of study-related expenses per year, depending on the course of study and subject to approval
- wellbeing initiatives, including the availability of a confidential employee assistance program.
Please view the AUSTRAC Enterprise Agreement (Word, 672KB) for further information on current salaries, and other conditions of employment.
Culture @ AUSTRAC
AUSTRAC is a dynamic place to work and provides the support for you to grow your career. Our people are our asset. We value performance and passion. No matter where you work at AUSTRAC you can really make an impact and you will have the feeling of being part of a success story. Watch our culture video and hear directly from our staff on how we do things here.
A day in the life
One of AUSTRAC's most important initiatives is the Fintel Alliance - a microcosm for much of the work we do. We relentlessly follow the money trail, exchange near real-time intelligence and use the best data, tracking tools and methodologies. We embrace change, seize opportunities and use our skills to work together to win the war against serious crime and terrorism financing. Watch our day in the life video to better understand the work you could do with us.
Being part of the APS also has the additional benefits of:
- working for an employer who is committed to work-life balance, learning and development, work health and safety, and equity and diversity in the workplace
- being able to access an extensive range of career opportunities
- being able to move between different agencies and departments without losing entitlements
- knowing that you are making a meaningful contribution to the Australian community.
Integrity in the APS
Together, the APS Values and Employment Principles shape the organisational culture of the APS. They are core components of a positive culture, stewardship, high performance, and leadership - and fostering 'one APS'.
All AUSTRAC employees are employed under the Public Service Act 1999 and required to comply with the Code of Conduct, including to at all times behave in a way that upholds the APS Values and Employment Principles, and the integrity and good reputation of AUSTRAC and the APS. AUSTRAC's procedures for determining a breach of the APS Code of Conduct are available below.
Procedures for determining breaches of the APS Code of Conduct and for determining sanction (Word, 87KB)
Procedures for determining breaches of the APS Code of Conduct and for determining sanction (PDF, 115KB)
Read more on the APSC website about Integrity in the APS.
AUSTRAC workplace diversity plan 2013-17
AUSTRAC is committed to creating a working environment that values and utilises the contribution and experience of our employees from a diversity of backgrounds. The main objective of the AUSTRAC workplace diversity plan
2013-2017 is a commitment to fostering a diverse and inclusive workforce. Harnessing the diverse skills, experiences and qualities of our employees enables us to be more efficient and innovative, enhancing our performance and leading to better business outcomes for AUSTRAC.
AUSTRAC workplace diversity plan 2013-17 (Word, 513KB)


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Biomechanical comparison of a new stand-alone anterior lumbar interbody fusion cage with established fixation techniques – a three-dimensional finite element analysis
- Authors
- Journal
- BMC Musculoskeletal Disorders 1471-2474
- Publisher
- Springer (Biomed Central Ltd.)
- Publication Date
- Volume
- 9
- Issue
- 1
- Identifiers
- Source
- Legacy
- Keywords
- Disciplines
Background Initial promise of a stand-alone interbody fusion cage to treat chronic back pain and restore disc height has not been realized. In some instances, a posterior spinal fixation has been used to enhance stability and increase fusion rate. In this manuscript, a new stand-alone cage is compared with conventional fixation methods based on the finite element analysis, with a focus on investigating cage-bone interface mechanics and stress distribution on the adjacent tissues. Methods Three trapezoid 8° interbody fusion cage models (dual paralleled cages, a single large cage, or a two-part cage consisting of a trapezoid box and threaded cylinder) were created with or without pedicle screws fixation to investigate the relative importance of the screws on the spinal segmental response. The contact stress on the facet joint, slip displacement of the cage on the endplate, and rotational angle of the upper vertebra were measured under different loading conditions. Results Simulation results demonstrated less facet stress and slip displacement with the maximal contact on the cage-bone interface. A stand-alone two-part cage had good slip behavior under compression, flexion, extension, lateral bending and torsion, as compared with the other two interbody cages, even with the additional posterior fixation. However, the two-part cage had the lowest rotational angles under flexion and torsion, but had no differences under extension and lateral bending. Conclusion The biomechanical benefit of a stand-alone two-part fusion cage can be justified. This device provided the stability required for interbody fusion, which supports clinical trials of the cage as an alternative to circumferential fixations.


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Solutions for Industrial Waste
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Make sure your materials end up in the right place. Our certified vendors are equipped to handle chemicals, electronic waste, universal waste, biohazardous materials and more, and offer recycling opportunities when possible that can boost your bottom line.
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Receive flexible support designed around your needs, whether it's a one-time initiative or a national program. Schedule pickups on demand, get total transparency into your waste and recycling costs, and track progress toward sustainability goals with our cloud-based technology.
Achieve savings and greater sustainability


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One thing that is constant with most people is that at some points in our lives we have lost the key to our cay, apartment or office. However, what is not constant is how many of those that have lost keys got urgent and stress free reprieve if they even had the number of a lock smith in their phone books. To escape being among those that have suffered in the cold the entire night or had to take the bus home to get the spare to the car, you should have our number and we can guarantee that not only are we the best expert locksmith in Phoenix but we will cover you on all levels. Our services include;
source: http://www.goldstarlocksmithphoenix.com/
Car locksmith.
How would you like to have the best and most experienced locksmiths coming to your rescue when you misplace the keys to your car? Well to many this may seem like a dream but to us this is our day to day duty. There is nothing as annoying as getting stuck beside the road locked outside your car and there is nothing as relieving as seeing the headlights of our service crew just minutes after you make the call. With top of the line tools, we can get you back in your in car in a heartbeat and with the least minimal damage to your car and most importantly the paint job!
House calls.
Letting a stranger into tour home especially when you're emotionally distressed can be heart wrenching. This is more so the case when they are there to take down and pick your locks so that you can get back in. We understand this. That is why we ensure that our crews are highly trained in people skills, they arrive in properly marked vans, in proper attire and ultimately they have name tags. This makes it easy for you, the client to identify with our service men and make the situation less tricky for you since you can be guaranteed that you can trust our employees and that they are an expert locksmith in Phoenix.
Emergency door unlocking.
How many times have you had an emergency because you locked your keys in or misplaced them? How many times have you had to look for alternatives because your expert locksmith in Phoenix took advantage of the situation to charge you money you didn't have or could not get on site at the time? You can be guaranteed that was not us. Our expansive team of locksmiths allows us to attend to huge number of clients concurrently without jeopardizing the quality of service that we offer even on short notice. We also ensure that we price our services reasonably. After all we would love you to recommend us to your friends. We believe that satisfied clients are the best advertising that any company can get.
Replacement of locks and key cutting.
Would you like to change the locks in your home, commercial building or office? Once again as an expert locksmith in Phoenix we will offer you unmatched service in this as well. Our experienced crew has the knowledge to install virtually any lock you may need in a safe and secure manner.
With us you don't need to have a variety of numbers to ensure that you're fully covered. You only need one number and we will cover all your locking needs in a fast, convenient, safe and utterly secure manner.


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There are many ways you can make a difference to Health in Mind. Whether you want to come and work for us in a paid role, or to volunteer your time and support in a voluntary capacity, we are keen to hear from you.
We rely on an army of volunteers to keep Health in Mind running, so there are lots of volunteering roles to get excited about. We've also been awarded Investing in Volunteers status for the second time! Read more about that here.
If you'd like to jump straight to volunteering opportunities, you'll find them here, but if you think you have skills that we could use, we would love to hear from you! Explore our volunteering section, or send us an email!
Although many of our services are funded by local authorities, NHS Lothian and the Scottish Government, we also need to fundraise in order to keep up our services. If you're interested in fundraising with us, check out our fundraising section.
As a charity we are of course always very grateful for any donations. If you would like to help us to continue our support, please donate to Health in Mind - and if you are a UK taxpayer please remember to add gift aid!
Service User Involvement
If you already using our services, we are happy to hear any suggestions you may have for improving them and we have a service user involvement policy in place to ensure that we involve and support service users to play an active role in the shaping of services.
Need help now?
If you or someone you care for is facing a crisis and in distress, please contact NHS 24 on 111 or your GP directly.
Click here for further information and contact details.
Training Calendar
Upcoming Training
September 2017
Tuesday 5 September-half day
Thursday 7 September - half day
Monday 11 September - Full day


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Let us know when your receive great advice so we can thank our lawyers and point others with similar questions in the right direction.Got it!
The drunk neighbor tried stealing my cat Smokey.
She stole him while I was gone then when I was searching for him he managed to get free and out of their apartment.
When he tried to run she grabbed him and tried hiding him in our downstairs neighbors house..
I had to bang on their door and threaten to call the cops, they let him out when they thought I was going to call the cops.
These people that tried taking him are the same who cut off his tail and abused their other two cats, one is a little older and one is a helpless kitten.
Is it right for them to hold my animal from me? I am a good caretaker for my cat, he is well fed and cared for lovingly. Do they have the right to do that, they have taken him before and last time he came back hurt when their cat attacked him. Is there anything I can do to stop them?Just to let anyone know I did not let the cat out, and did not know he was out until I had gotten a message from my mother. They have also tried taking the cat off of our porch and have grabbed his leash from me without permission as i had been walking him.
You also have a right of replevin to seek the return of personal property which animals are considered. Call animal control or law enforcement if they get your cat again, but don't let it run around outside.
Statements made in response to questions on this site are for informational purposes only and do not constitute an attorney-client relationship.Ask a similar question
Call the cops. That is your best option. Also, take steps not to let your cat out unsupervised, if these people are dangerous to animals as you claim.
We do not have an attorney-client relationship. I am not your lawyer. The statements I have made do not constitute legal advice. Any statements I have made are based upon the very limited facts you have presented, and under the premise that you will consult with a local attorney. This is not an attempt to solicit business. This disclaimer is in addition to any disclaimers that this website has made. I am only licensed in California.Ask a similar question
A call to animal control regarding the abuse of the cats seems to be in order.
In Virginia companion animals like Smokey are considered the owneer's personal property. Your neighbors can no more take Smokey and keep him from you than they could any other item of your personal property. I agree with the others who answered that next time you should call the police. If your neighbors know that you are serious about their taking Smokey, they will probably stop this bizarre conduct.
This answer is a general response to your rather broad quetion and is not meant to be formal legal advice. For a more specific answer to your question, you need to discuss all the specific facts of the case with your attorney.Ask a similar question
Post a free question on our public forum.Ask a Question
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Since its inception just last year, HAZE Collection has proven itself as a brand to watch within the innovative eyewear arena. With a focus on using the finest material, boundary-pushing designs and a crisp, sleek brand image, HAZE has positioned itself amongst today's leaders of contemporary eyewear.
At the core of HAZE is its commitment to creating product of the highest echelon. Each frame is cut from slabs of pure acetate, sourced firsthand in Italy. This means that no frame is identical; each marble nuance is almost personalized for the wearer. Focusing on fusing traditional design with a fresh contemporary style, HAZE uses a number of innovative techniques and details that make the collection truly unique.
The brand employs its patent pending SWIV3L™ engineering on a three-pronged, metal hinge that ensures maximum durability, and uses luxe additions such as titanium nosepieces that give the various styles a chic, elevated durability.


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Omaha, NE (PressExposure) July 23, 2009 -- BIM 4D Services firm use latest design technology for various building model in 4d construction. BIM 4D provides various high quality building information models such as architectural BIM model, structural BIM model, and MEP BIM model as per the clientâs requirement at very competitive rate. Outsource to us and save 40%-60% on your building information models.
We have an experienced team of engineers who strive continuously to provide efficient and effective building information models in building construction by using state of the art systems. BIM 4D provides building information models in various industrial areas such as residential, commercial, educational, hospitality, institutional etc..
We offer high quality, low cost global outsourcing services in BIM (Building Information Modeling), Architecture, Structure, Mechanical, Electrical and Plumbing (MEP). We have suitably qualified staff in every design discipline. Our BIM 4D companies has many years of experience and still now extending our production to the various area most high population city.
We create excellent 4D building information models for:
⢠Structural BIM ⢠Architectural BIM ⢠MEP BIM
BIM 4D Firm aims to provide various building information model at 100% precision using existing standards and latest technology. The company offers flexible and tailor-made solutions to suit your needs and requirements for all price points. The company offers affordable and attractive hourly and man-hour pricing building information models depending on the complexity and volume of work. It provides high-level project development & management support - leaving clients to focus on the rest of their business.
Visit http://www.bim4dservices.com/ to see building information models or send us your query at info@ bim4dservices.com and we will get in touch with you shortly.


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- Services
- Colon Hygiene
- Detoxification & Tissue Regeneration
- Woods Gravity Hygiene Training
- Naturopathy
- Schedule Online
- Contact
- Cleanse
- Blog
This is perfect for someone who is not quite ready for a full flush (beginner internal cleanser), this is nice and easy and doesn't require a lot of prep time. Ingredients:
Zap all the ingredients in a blender, pour and drink. It is delicious!" Drink every day one glass of this for several weeks, if you are suffering from: Gallbladder attacks, allergies, indigestion, abdominal pain, arm pain, back pain, constipation, bursitis, or any chronic health problem. Avoid or replace ingredients you may be unable to tolerate, like garlic. Lemon can be replaced with orange, grapefruit or lime.
A Powerful Do-It-Yourself Tool To Optimize Your Health And Wellbeing By Andreas Moritz
In this revised edition (2005) of his best-selling book, The Amazing Liver Cleanse, Andreas Moritz addresses the most common but rarely recognized cause of illness – gallstones congesting the liver.
Twenty million Americans suffer from attacks of gallstones every year. In many cases, treatment merely consists of removing the gallbladder, at the cost of $5 billion a year. But this purely symptom-oriented approach does not eliminate the cause of the illness, and in many cases, sets the stage for even more serious conditions. Most adults living in the industrialized world, and especially those suffering from a chronic illness such as heart disease, arthritis, MS, cancer, or diabetes, have hundreds if not thousands of gallstones (mainly clumps of hardened bile) blocking the bile ducts of their liver.
This book provides a thorough understanding of what causes gallstones in the liver and gallbladder, and why these stones can be held responsible for the most common diseases so prevalent in the world today. It provides the reader with the knowledge needed to recognize the stones and gives the necessary, do-it-yourself instructions to painlessly remove them in the comfort of one's home. It also gives practical guidelines on how to prevent new gallstones from being formed. The widespread success of The Amazing Liver Cleanse is a testimony to the power and effectiveness of the cleanse itself. The liver cleanse has led to extraordinary improvements in health and wellness among thousands of people who have already given themselves the precious gift of a strong, clean, revitalized liver.
For ease of shopping, this Amazon store has everything you need to complete several Liver Gallbladder Cleanses. Total cost around $135 divided by 10-12 liver cleanse sessions. Much more economical than removing a gallbladder? Yes!
Supplies & Protocol LIVER CLEANSE
Phase 1: 3 Days Prior to Cleanse Start to follow a raw living foods diet, which means that nothing is heated above 105 degrees. Remove all animal products from your diet during this cleanse as well as grains. Your diet will consist of organic fruits and vegetables, seaweeds, nuts, seeds, and Superfoods only! You will transition over to a raw foods diet three days prior to the first day of your cleanse so that your body will have time to adjust before we start to remove mass amounts of stored toxins.
Phase 2: Days 1-3 Continue following a raw vegan diet. Follow the steps listed below in chronological order, unless otherwise specified. Brush your teeth and use your tongue scrapper
Phase 3: Day 4 Today is your first flush. Be sure to drink plenty of fresh apple juice throughout the day.
Phase 4: Day 5
Phase 5: Days 6-7
Phase 6: Day 8
Phase 7: Days 9-10
Begin to come off of the fast slowly by introducing minimal amounts of solid foods daily. I would continue to follow a raw foods diet since it will continue to detoxify your body and allow the body to continue to heal itself. According to David Wolfe, one should follow a raw lifestyle for 18 months to really allow the body to begin to release the mucus body that has been building up over years of improper eating.
* If you have gallstones you will see them on days following a flush in your stool. They will be green in color and vary in size.
Preparing a castor oil pack is simple but a little messy.
First you want to make sure you have a towel that you can stain, some saran wrap, and a piece of flannel or wool cloth.
Step One: Soak the cloth in castor oil
Step Two: Place the cloth on the right side of your abdomen, which is above your liver
Step Three: Wrap your abdomen with saran wrap so that the cloth is secured
Step Four: Place a heating pad or hot water bottle on top of the cloth and plastic
Step Five: Lay down for thirty to forty minutes on your right side
Step Six: Remove all items and wash the area well with soap


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Pop the Question Contest Entry
Title: Forget Hollywood
Word Count (without the A/n and header): 3057
Pairing: Edward/Bella
Rating: T
Summary: Long time couple Edward and Bella are having a movie night at home. Will the chosen movie, Sweet Home Alabama, inspire them to take the next step? And if so, how?
Warnings (if any): There are no sensitive subjects in this fic, at least not intentionally. However, there is a lot of copywrited material, from Twilight to Sweet Home Alabama. If a disclaimer is needed, let this be it: I own nothing.
Forget Hollywood
"Is there any way I can get you to change your mind?"
Bella pursed her lips, pretending to give Edward's question any consideration. She knew that he didn't like romantic comedies, and since he started his internship, they've hardly seen each other, even though they live in the same little rented house. The urge to just give in to his every whim, whenever they were together, was strong, very strong. It only got stronger the more she looked in his pleading, intensely green eyes, the more she studied his incredibly sexy pout. And he knew it, too, the rascal. He used it without shame.
But, on the other hand, she needed the extra sugar in her day. She was finishing up her course load for her master's degree in library science, and it was killing her. Besides, they had both agreed long ago to the movie-night rules, after many frustrated attempts and even a few fights. He already knew the answer, even as he asked the question.
"Hmm ... Nope." she finally said. "I won the rock-paper-scissors contest fair and square, Cullen. Rules are rules. Now push Play."
"Yes ma'am." Edward's grin belied his (greatly exaggerated) annoyed tone. He didn't mind the movie ... so much. He didn't expect it to be any good; it was a ten years old romantic comedy named after an almost forty years old song, which was fighting Hotel California for "most overplayed song ever". But it made his girl happy, so what was he gonna do?
He was gonna push Play, that's what.
They settled down as the opening music started. Bella turned her attention to the movie. Edward turned his attention to Bella. He didn't spend enough with her, just enjoying her. He could say that he was busy, with med school, and that would be true enough, but even if he hadn't been studying to become a doctor, even if he'd been a multimillionaire who could spend his days doing nothing but follow her around, he still wouldn't have enough time to just be with her. They could both be immortal, spending the rest of eternity together, and still, Edward wasn't sure that would be enough time.
He would have to make do with the time given to him, the present moment. He watched her smile at the screen, played with her hair. It was shorter now than it used to be. When they first met, her hair reached down to the small of her back. At some point, in their second year of dating, she decided that it was just too much bother, and she cut it up to her chin. Then she decided that that was too short, and she let it grow out. When it reached her shoulders, she decided that was the perfect length.
Her struggles and frustration had made Edward chuckle. He didn't care about any of that, as long as it was long enough for him to play with. And if it wasn't, if she decided to get a pixie cut, or worse, shave it all off ... well, he'd figure something else. It was Bella that mattered, not her hair.
"Do you know who wrote that?" asked Bella after a short while. The question confused him for a moment, distracted as he was by his inner monologue about her hair.
"The movie? How would I know?"
Bella rolled her eyes at her boyfriend's confusion. "No, not the movie. The song. Sweet Home Alabama."
"Oh. It's Lynyrd Skynyrd."
"No, really?"
Edward nodded. "Seems to me we need another study-buddy session, baby."
They smiled at the memory of their first meeting. They were freshmen at the University of Illinois, Bella in English and Edward in Pre-Med, and they had chosen the same elective: Introduction to music, because it sounded easy. For Edward it was. For Bella, not so much. Edward jumped in when he was offered the opportunity to tutor the pretty girl he had noticed in class, and though Bella objected to the term "tutor", she didn't mind the idea of a study-buddy, especially one as nice and as cute.
The study sessions were first held in the library, until Bella timidly suggested that it might help her if she could hear the music examples, which wasn't really possible in the library. They began to meet in common rooms of their dorms, and eventually in their dorm rooms, when their roommates were busy elsewhere. The relationship evolved so easily, so naturally, it was like breathing. By the end of the semester, Bella had not only managed to get a B in intro to music, she also had a steady boyfriend.
They spent their Christmas break together, and even had Christmas dinner with Edward's family, who resided in Chicago. They continued to date through the next semester. When summer came, Bella had to leave Illinois and return to Forks, Washington for the summer. The separation was hard, but they made it. They call each other every night. They also kept in touch using Facebook and Twitter and Tumblr, until their parents started to complain that they spent all their time at the computer. Edward even managed a surprise visit to Forks, so he could meet Bella's parents. The amount of effort he took to please her parents was the last argument Bella needed; Edward Cullen was definitively the perfect man for her.
When fall rolled back again, they picked up right where they left off. The cycle continued all though their undergraduate years. The summer before graduate school, they announced that they were moving in together, to the shock of absolutely no one. They looked at apartments, at first, but then they stumbled on the most adorable little house to rent. They considered getting a dog, to go with the yard that came with the house, but Bella learn to her eternal embarrassment that she shared her mother's allergies to dogs, so that plan was scratched. They enjoyed the good days and worked together to get through the bad ones.
Their friends and family had started to say their two names as if it was one word; Edward-and-Bella, Bella-and-Edward. Almost from the start, there had been a lot of teasing aimed at the two sweethearts, from "when's the wedding" to "don't you dare make me a grandmother until I'm at least fifty". The former was a lot more common than the latter, especially since both Edward and Bella's mother had turned fifty. Apparently, fifty was the magical grandmother age. The love birds bore the teasing with a smile. They never talked about their couple and their future plans with family and friends. They were discreet, and preferred to enjoy their private lives privately.
"I think we have better things to study," she answered, licking her lips and leaning toward him until their mouths were less than half an inch away from each other. With their breath mingling and the tension quickly rising, she whispered: "After the movie."
Bella giggled at Edward's groan. She tried to lean back, but he was having none of it, wrapping one arm behind her back and the other around her legs, keeping her firmly pressed against him. "You are a tease."
"Just watch the movie. The best part is coming up."
"The best part? Ten minutes in? This is going to be a long night."
"One of the best part, then."
On the screen, Reese Whiterspoon and Patrick Dempsey walked in a dark, vaguely cavernous-sounding room. The lights come on to reveal the engagement ring floor at Tiffany's. The first time Bella saw this movie, this moment felt like a modern fairy tale, a bit over the top but still terribly romantic. At each repeated viewing, she always let a little sigh. But this time, she was distracted by Edward's snickers.
"Edward! Don't be like that. This is romantic."
"Romantic? Look at her face, she's terrified!"
It is true that Reese's reaction with Patrick got down on one knee was far from optimal.
"There are extenuating circumstances."
Patrick is now back up on his feet, and he's telling Reese: "I don't usually ask questions I don't already know the answer too."
"Of course, you don't," said Edward mockingly.
"Seriously, Bella, don't you think it's a little weird. I don't mean just in that movie, I mean everywhere. You have a guy and a girl. They've been dating an indeterminate amount of time. The guy decides, "I like this girl, and I want to spend the rest of my life with her" Does he talk to her about it, maybe see what she thinks about it, plan for the future together? No. Instead, he spends weeks, or months, sneaking around, planning this perfect proposal in complete secrecy, because God forbid she should figure it out before he's ready. And when the moment finally arrives, the girl is completely blindsided. She has like three seconds to answer. And if she says no, then it's basically the end of the relationship. Is that really what romance is? Really?"
Bella had to admit that, put that way, Edward had a point. It was one of the things she best liked about him: he had no tolerance for game playing, especially in a relationship. He'd just tell it like it is, and expected everyone to do the same.
Still ...
"I'm not saying that you're wrong, but you're kind of bursting my modern fairytale bubble, here."
"I'm sorry, baby." Edward wrapped his arms around Bella, gathering her in a hug. "I came on too strong, didn't I?"
"Nah, it's okay. I owed you one after my "jealousy and possessiveness aren't sexy" rant of the other day."
"You were right, though."
"So were you just now. Aren't we smart cookies?"
She looked so adorable, in her mockingly smug attitude, Edward had to kiss her. Just a quick kiss, before she could complain about missing any more of the movie.
On the screen, Patrick Dempsey's overbearing mother discovered the engagement Reese wanted to keep secret. Reese then took a plane to Alabama. When Reese demanded that Josh Lucas gave her a divorce, Edward exploded with laughter.
"Oh, man alive!" Edward finally said once he caught his breath. "See that, McDreamy? That's the kind of thing you would've known if you'd talked about marriage with Reese before proposing."
"Well, to be fair to Patrick, Reese probably would have lied. She had no business accepting the proposal as it was."
"That is true. That is very true."
After a few moments of silence, Edward asked: "So, what do you think of marriage, in general?"
"Hmm." Bella hesitated for a moment, surprised by the question. "Well, I guess it depends on what you mean. The part where two people in love make the commitment to stay together, celebrate the joys and share the sorrows of life, I'm in favour of, absolutely. But if you mean, like, a wedding ... I'm not sure."
"You're not sure?"
"Yeah. I mean, it's like for some people, the whole relationship culminates in that one, big event, and it becomes a circus. You can ruin yourself planning a wedding and a honeymoon, you know. When you spend the kind of money that would buy you a good second hand car on one dress, that you'll wear one time, you know things have gotten out of hands. And it's like, at the same time, the relationship isn't real until the wedding. That's the point of the bachelor's party, right? One last night of screwing around and the next day you commit yourself to one person forever. Wasn't the engagement the commitment?"
Edward pondered over what his girlfriend had told him for a while. "That would be an interesting concept. The guy calls all of his friends and says, I'm getting engaged tomorrow, let's go to a strip club!"
Bella laughed. "Yeah. And when he proposes, the next day, the girl would say; Sure, but let's wait until tomorrow, I've got to get the girls together for a last wild night out."
"But seriously, sounds like you're not in favour of big weddings."
"I'm not, I guess. But on the other hand, I like the idea of a big reception. Everybody dressed in fancy clothes, with awesome food and music, and games. There should be games, too. It should be, like, I choose to spend the rest of my life with that person, and it's the best thing in the world, and I want all my friends and family to celebrate that with me. Does that make me a hypocrite?"
"No, why?"
"Well, big weddings and big receptions kind of go together. It's not like you can have a small, intimate ceremony and a huge reception."
"Why not? That actually sounds kind of nice. Like the royal wedding, but in reverse."
Bella smiled. "You're sweet." Her expression turned pensive, though, as the conversation of the last half hour began to run in her mind.
What this what she thought it was?
"Yes, Bella?"
"It sounds like we're talking about getting married."
"It sounds that way, doesn't it?"
That was unhelpful. Bella would have to prod him some more.
"Yes, Bella?"
"What do you think about wedding and marriage?"
"I agree with you, for the most part. A marriage is as good, or as bad, as the attitude of the people in it. And the way you describe the reception, friends and family gathering to celebrate a wonderful relationship that will last for the rest of our lives, that's the way I feel about weddings. There's just one thing."
"I want a church wedding. It's very important to me."
"Okay," Bella agreed immediately, even though she found the request a bit strange. Edward, though he came from a religious family, was not overtly religious in his daily life. "Is it because of your grand-father?" she asked, referring to the father of Edward's father, who was an Anglican pastor.
"Not really. Well, in a way, since he influenced my father. Dad wasn't as strict as Grandpa was with him, praying for half an hour every night, helping with all the services, every Sunday. But he did teach me to give thanks for the good things in my life. And that's what I want. It's like a church wedding is the only proper way to give thanks to God for you, because you're the best thing that happened to me."
The sweetness, the heartfelt sincerity of the statement, was too much for Bella. She just had to kiss him again.
"So," she asked when she came up for air. "We're getting married."
"We're getting married," Edward confirmed. "Soon."
Bella hesitated. "How about soon-ish?"
The hesitation made Edward nervous."Why?"
"It's the last year of my master's, and it's a crazy busy time for me. Plus, you're just starting you internship and you have almost no time to yourself, let alone the time to plan a wedding and take a honeymoon. I mean, we are taking a honeymoon, right? We haven't talked about it, but, you know, I kind of assumed..."
The rush of words tumbling out of Bella's mouth reassured him. She wasn't trying to back off, or to let him down easy. She really wanted this, as much as he did.
"I assumed the same thing. A honeymoon is a must. Did you have anything in mind?"
"Well, I have no idea what out budget is. I only have a general idea. You know, like, I would prefer a cottage in the mountains to a tropical beach resort."
"Really. Why, do you want a tropical beach resort?"
"No, but I figured you would. You love being out in the sun."
"I do. Unfortunately, the sun doesn't love me back. With this skin," she added, holding up one alabaster hand, "I would end up writhing in pain from the terrible sunburns. Not my idea of a good time. Plus, a cottage in the woods seems romantic."
Edward grabbed her hand and peppered it with little kisses. "All right. A cottage in the woods it is."
Edward's lips eventually reached the spot just over the knuckle, on her ring finger.
"Hey, that reminds, me," Bella exclaimed. "Do you have a ring?"
"No. It's your ring, why would I buy it without you? What if you don't like it? What if it doesn't fit you? Then you have to get it resized, and it's awkward. We'll go shopping tomorrow, if you want."
"I want," Bella answered, and they leaned toward each other until their lips met.
"At the risk of bringing more torture to myself," Edward eventually asked, "we've missed a lot of the movie. Do you want me do rewind it?"
"Nah, just leave it be. The best part was the Tiffany's proposal, anyway."
Edward laughed at this. "Well, I might as well turn it off, then."
"No, leave it on. I need to background noise to think. We have a wedding to plan."
"That's the second time you've said that in five minutes. Aren't we doing a small, intimate wedding? How much planning can be involved?"
"I'm not sure, but I think a lot. We're also planning a huge reception, and that is a lot of details. Besides, the more solid our wedding plans are, the better armed we'll be when we face our mothers."
"Oh, our mothers."
"You know they'll beg to let them plan everything, and then turn the whole thing into a circus."
"It's almost enough to make you want to elope."
"Don't you dare, Edward Cullen!" She slapped him across the shoulder, to let him know exactly how not funny she found his joke. "Eloping would be uncool."
"Don't worry, Bella Swan-soon-to-be-Cullen. I said almost. And I'm pretty sure our mothers won't be that bad. As long as we involve them in the process a little."
"All right," Bella said, slightly mollified. "About that soon-to-be-Cullen thing, I don't know how big of a deal it is to you, but I was thinking of hyphenating my name."
"The future Mrs Bella Swan-Cullen? I don't mind. It's not like we'd squish the names together, like Swullen or something."
"You're kidding me! People do that?"
"Some people. Not us, please."
"No problem."
They spent the rest of the evening planning and dreaming and kissing, with the movie long forgotten playing in the background.


text:
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text:
(RICE) Plus Bortezomib (Velcade) in a Dose-Escalating Fashion for Patients With Relapsed or Primary Refractory Aggressive B-Cell NHL
Once subjects are determined to be eligible and informed consent is obtained,patients will
be enrolled into a starting dose cohort of 1.0mg/m2. Based upon a satisfactory safety
profile, additional patients will be enrolled into the 1.3, 1.5 and 1.7mg/m2 cohorts. Each
of these dosing cohorts will only be enrolled if satisfactory safety profiles in each of the
lower dosing cohorts are obtained. As the process continues, multiple cohorts will be
receiving various dosing regimens simultaneously. If a DLT occurs in ≥2 out of 6 patients
at the initial dose level, then 3 more patients will be accrued at dose level -1 (0.7mg/m2).
Bortezomib will be given on days 1 (prior to rituximab) and 4, rituximab 375 mg/m2 on day 1,
carboplatin AUC 5 and ifosfamide with mesna, each 5 gm/m2, on day 3 and etoposide 100 mg/
m2/day on days 2, 3 and 4 of a 21-day cycle. They will also receive filgrastim on days 6-13
or pegfilgrastim on day 6. Dose-limiting toxicities (DLT) include any grade 3 or 4
non-hematologic toxicities (except alopecia and grade 3 febrile neutropenia), grade 4
febrile neutropenia (life-threatening sepsis) and grade 4 neutropenia persisting past day 35
or grade 3 or 4 thrombocytopenia persisting past day 35.
If there is a DLT at a given bortezomib dose level, 3 more subjects will be enrolled at that
dose; if there are 2 or more DLTs then the MTD will be defined as the previous dose level.
If at that dose level, >50% of subjects required bortezomib dose reduction, the MTD will be
defined as the next lower dose level. Subjects will continue to be accrued in order to
treat a minimum of 10 patients at the MTD.
Those who are candidates for autologous stem cell transplant will have CT scan of the neck,
chest, abdomen and pelvis after 2 cycles. Subjects with PD or SD will be taken off study.
Those with CR, PR or response not meeting PR criteria will undergo a total of 3 cycles of
bortezomib + RICE. After the 3rd cycle of bortezomib + RICE, whole body PET/CT scan and
bone marrow biopsy will be obtained.
Subjects who achieve CR or PR will then proceed to stem cell mobilization and collection by
a standard regimen, followed by autologous stem cell transplant with a preparative regimen
to be determined by the investigator. Those with SD or PD will be taken off study. While
the mobilization and ASCT procedures are not part of the phase I protocol, outcomes of ASCT
will be followed, including CD34+ progenitor cell collection, clinical response to
transplant and survival.
Subjects who are not candidates for autologous stem cell transplant will have CT scan of the
neck, chest, abdomen and pelvis after the 2nd and 4th cycles. Those who are responding will
continue for a maximum of 6 cycles.
Allocation: Non-Randomized, Endpoint Classification: Safety Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
Determine the MTD of Velcade (bortezomib), Rituximab, Ifosfamide, Carboplatin, Etoposide (V-RICE) for patients with relapsed/primary refractory aggressive B-cell non-Hodgkin's lymphoma (NHL)
5 years
Lawrence Kaplan, M.D.
Principal Investigator
University of California, San Francisco
United States: Institutional Review Board
May 2007
April 2012
|Unviersity of California Medical Center
|San Francisco, California 94143


text: Title asks all. Obviously the ending was left somewhat open-endedly. What do you guys think? Retrieved from "http://icarly.wikia.com/wiki/User_blog:Cc71/iLove_You_ending-_Make_up_or_Break_up%3F?oldid=503289" Ad blocker interference detected! Wikia is a free-to-use site that makes money from advertising. We have a modified experience for viewers using ad blockers Wikia is not accessible if you've made further modifications. Remove the custom ad blocker rule(s) and the page will load as expected. Category: Blog posts


text:
We continue from the earlier post. As in the earlier post, much of this post content are taken from Franz Baader's lecture notes (freely available on the web) of which I claim no authorship whatsoever.
Knowledge-based programming can be generalized into an area called knowledge representation. More precisely, a prerequisite for knowledge-based programming is that the relevant knowledge needs, in some way, to be represented symbolically, and thus stored in a machine/computer. Obviously, the way knowledge is represented should enable a machine, or in this case, a general problem solver to process it and answer the queries given to it. Again, following Franz Baader's lecture notes, the following are the important subtasks in knowledge representation:
- knowledge acquisition;
- symbolic representation;
- working with and applying the represented knowledge.
Knowledge acquisition
Knowledge acquisition is a difficult task because essentially, knowledge that we would like to represent is human's knowledge. After all, the notion of knowledge makes much more sense when discussed within human context; it is arguably absurd to talk about knowledge of a table, knowledge of a stone, knowledge of a bird (well it may have something that resembles knowledge, but strictly speaking, we would call it instinct, rather than knowledge), or knowledge of a book (a book may contain knowledge, though in the end what it contains is human's knowledge).
There are various ways to acquire knowledge about the application domain which is needed to solve the relevant problem, for example, by interviewing experts, mining documents, etc. Obviously, this implies that we have to start from a very informal, imprecise, and incomplete description of the domain to a more formal, machine processable specification. This topic is a very broad research area that overlaps with many other research area including learning and knowledge engineering. For our discussion, we will not deal with this issue explicitly. The reader are recommended to look at other literatures which can be easily found online. From now on, we simply assume that we have a way to acquire knowledge in an effective manner.
Symbolic representation
There are several meaning of the word "representation" if we look into dictionary. We do not intend to discuss them in details, but rather, we understand that representation indicates a connection between things in the real world and things that we use to depict them. For our discussion, symbolic representation is actually a depiction or description of some real world entity that is symbolic in nature. In the research area of knowledge representation and reasoning, the following questions are discussed [Baader, 2005].
- What is the exact connection between the symbolic representation and the real world entities it is supposed to describe?
- What formalism is used to represent the knowledge?
- What is the meaning (semantics) of the chosen formalism?
These questions give rise to a plethora of formalisms, methods, techniques, approaches, whatever — you name it, to represent knowledge. In a more general sense, knowledge representation can be classified into ones which are symbolic and ones which are not. The latter includes artificial neural network or connectionist systems and evolutionary computation. The other approaches like fuzzy systems and statistical-based systems, although heavily non-symbolic in nature, can be integrated with symbolic approaches in a rather seamless manner. The third question above is, in particular, frequently not applicable (at least in a rather straightforward way) to non-symbolic approaches like artificial neural network. It is undeniable that such systems do work and solve problems in applications robustly and efficiently. However, such systems typically lack semantics. For example, take any artificial neural network system which has been trained for some period of time to classify documents according to their topics. Presumably, the weights of connections between neurons in that system represent the knowledge necessary to perform the classification correctly. Unfortunately, there is no way for us to understand what is the relationship between certain configuration of numerical weights of connections between neurons and the fact that document A has topic X or document B has topic Y. Such a gap is very difficult to close, despite the efforts that have been made so far, e.g., research in neural-symbolic integration (see e.g., the 7th International Workshop on Neural-Symbolic Learning and Reasoning (NeSy'11), or the "Perspective of Neural Symbolic Integration" book).
For the purpose of our discussion here, we would only concern ourselves with symbolic based systems, more specifically, logic-based knowledge representation (LBKR) systems. Aside from the above three questions, research in LBKR also investigates the expressivity aspect, i.e., the adequacy of the expressive power of the chosen formalism. The question of expressive power essentially asks what statements can be formulated and what cannot within a given formalism which is restricted to the representational means defined for it. The more expressive a formalism is, the more knowledge can be presented. Of course, such a formalism can be considered adequate only when all the relevant knowledge can be presented. As an example, the sentence
There exists no prime number that is greater than every other prime number
cannot be adequately expressed using propositional Boolean logic that only uses connectives like conjunction (AND), disjunction (OR) and negation (NOT). This example illustrates that the expressive power of propositional logic formalism is not adequate to express the above sentence. On the other hand, it is also a common question to ask whether all of the representational means attributed to the formalism are really needed, that is, whether some of the representational means is redundant. For example, in propositional Boolean logic, it is sufficient to use only conjunction and negation to express all statements that can be expressed using propositional Boolean logic. In other words, the disjunction operator is redundant in the presence of conjunction and negation.
On the semantics, LBKR systems are expected not to depend solely on any procedural semantics. This means that the semantics should never depend on particular programs that are built to do whatever tasks which are assigned to the systems. If this is the case, then the semantics, i.e., the meaning, of knowledge would change if the program is changed. Instead, they should have declarative semantics, hence separating the representation and the programs that are used to process it. A declarative semantics essentially consists of an abstraction of the world that we want to represent together with a mapping from any symbolic expression allowed in the formalism to an element in the abstraction. Such an abstraction is often stated in a form of a set or other algebraic structures. Representational means of the formalism usually allows us to build more complex symbolic expressions from simpler ones. Thus, the mapping given by the semantics typically associates the representational means with some operations on the abstraction. In addition, declarative semantics specifies a notion of "truth" which is used to determine whether a symbolic expression is true in the world induced by the abstraction. Moreover, the relationship between representational means and operations on the abstraction allows for the "truth" of a symbolic expression to actually be computed.
Working with and applying the represented knowledge
LBKR systems, in addition to the above requirements, should allow users to do some kind of manipulation in the form of [Baader, 2005]:
- adding new knowledge to existing knowledge bases;
- removing knowledge from a knowledge base;
- accessing the explicitly stored knowledge;
- accessing the implicitly stored knowledge
The above activities can be viewed as knowledge management activities which similarly exist for database systems. In fact, in some sense, a (relational) database system can be considered as a form of knowledge-based system. This fact can be easily seen if we see a database as a set of relation which can be expressed as simple first-order logic statements. Also, queries to a database, say stated using SQL, are actually first-order logic statements whose truth are tested against the relations in the database. The feature that a standard database system lacks is the ability to access implicitly stored knowledge. This feature implies that a LBKR system should be able not only to retrieve knowledge that is stored explicitly, but also to deduce implicit knowledge that is implied by the explicitly stored knowledge. Such a feature is called inference mechanism or inference procedure. Referring to my earlier post on "Classical Programming vs. Knowledge-based Programming: Example", the general problem solver mentioned there would be realized here as inference mechanisms. As an example, we use the one from that post; consider the following knowledge base:
directly-connected(a,b). directly-connected(a,c). directly-connected(b,d). directly-connected(b,e). directly-connected(c,e). connected(x,y) if directly-connected(x,y). connected(x,y) if directly-connected(x,z) and connected(z,y).
Here, directly-connected(a,b) is explicit knowledge because it is explicitly stated in the knowledge base above, whereas directly-connected(a,c) is implicit knowledge because it is implied and not explicitly stated by the knowledge base.
Related articles
- Classical Programming vs. Knowledge-based Programming (krisnadhi.wordpress.com)
- Classical Programming vs. Knowledge-based Programming: Example (krisnadhi.wordpress.com)


text:
Sleep parameters, functional status, and time post-stroke are associated with offline motor skill learning in people with chronic stroke
Issue Date2015-10-30
Sienguskon, Catherine
Al-Dughmi, Mayis
Al-Sharman, Alham
Stevens, Suzanne
Article Version
Scholarly/refereed, publisher version
Copyright ©2015 Siengsukon, Al-Dughmi, Al-Sharman and Stevens. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
MetadataShow full item record
Background: Mounting evidence demonstrates that individuals with stroke benefit from sleep to enhance learning of a motor task. While stage NREM2 sleep and REM sleep have been associated with offline motor skill learning in neurologically intact individuals, it remains unknown which sleep parameters or specific sleep stages are associated with offline motor skill learning in individuals with stroke. Methods: Twenty individuals with chronic stroke (>6 months following stroke) and 10 control participants slept for three consecutive nights in a sleep laboratory with polysomnography. Participants practiced a tracking task the morning before the third night and underwent a retention test the morning following the third night. Offline learning on the tracking task was assessed. Pearson's correlations assessed for associations between the magnitude of offline learning and sleep variables, age, upper-extremity motor function, stroke severity, depression, and time since stroke occurrence. Results: Individuals with stroke performed with significantly less error on the tracking task following a night of sleep (p = 0.006) while the control participants did not (p = 0.816). Increased sleep efficiency (r = −0.285), less time spent in stage NREM3 sleep (r = 0.260), and more time spent in stage REM sleep (r = −0.266) were weakly-to-moderately associated with increased magnitude of offline motor learning. Furthermore, higher upper-extremity motor function (r = −0.400), lower stroke severity (r = 0.360), and less time since stroke occurrence (r = 0.311) were moderately associated with increased magnitude of offline motor learning. Conclusion: This study is the first study to provide insight into which sleep stages and individual characteristics may be associated with offline learning in people with stroke. Further research is needed to delineate which factors or combination of factors promote offline motor learning in people with neurologic injury to best promote motor recovery in these individuals.
A grant from the One-University Open Access Fund at the University of Kansas was used to defray the author's publication fees in this Open Access journal. The Open Access Fund, administered by librarians from the KU, KU Law, and KUMC libraries, is made possible by contributions from the offices of KU Provost, KU Vice Chancellor for Research & Graduate Studies, and KUMC Vice Chancellor for Research. For more information about the Open Access Fund, please see http://library.kumc.edu/authors-fund.xml.
Siengsukon, Catherine, Mayis Al-Dughmi, Alham Al-Sharman, and Suzanne Stevens. "Sleep Parameters, Functional Status, and Time Post-Stroke Are Associated with Offline Motor Skill Learning in People with Chronic Stroke." Frontiers in Neurology Front. Neurol. 6 (2015): n. pag. http://dx.doi.org/10.3389/fneur.2015.00225
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text:
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The letter J for Children. MP3
The Alphabet Letters for children. Learning the letter J from the Alphabet Song. A fun & engaging video of a toddler Jumping into a swimming pool and narrating ...
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Ray J -Jump off MP3
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Join Wrongtom and Deemas J in East London, in the new multi-million-pound promo video to celebrate the release of their new single "Jump + Move + Rock", ...
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J-Stars Victory VS+ - Jump Festa Trailer MP3
J-Stars Victory VS+ is coming to the Americas on PlayStation 3, PlayStation 4, and PlayStation Vita! With it's Western release, J-Stars Victory VS is also getting ...
Ray J - Jump off with lyrics MP3
one girl is my jump off, one girl is my wife...
J-Stars Victory Vs - Jump Festa 2014 Gameplay Trailer (PS3/Vita) MP3
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J Rabbit - JUMP (Cover) MP3
original sung by Dong-Ryul Kim Covered by J Rabbit with New Mic :-)
Triple J - Jump MP3
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Sesame Street - J Jump for Joy MP3
Some of those jumps looked pretty painful there.
LL Cool J - Jump On It MP3
a great track from LL Cool J - Jump On It off his new album Authentic (2013)
Jessie J - Burnin' Up ft. 2 Chainz MP3
Download "Burnin' Up" by Jessie J now: http://smarturl.it/JSJSweetTalkerdlxDA Music video by Jessie J performing Burnin' Up. (C) 2014 Republic Records a ...
Burnin' Up
Jessie JJessie J Walking through the fire Please don't let me go Take me to the river I need you to know I'm burnin' up Come put me out Come and put me out I'm burnin' up Come put me out Come and put me out Hot in the kitchen like a thousand degrees That's how I'm feeling when you're next to me I got a fever, tell [...]
Jessie J - Domino (Jump Smokers Remix) MP3
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The Warning Signs of Clogged Arteries and Ways to Improve Them
It is a serious condition, clogged arteries, causing limitations in the blood flow. The fat in the arteries stops the blood from reaching the most important organs in the body. They stop functioning properly, not because of the lack of blood, but because their cells don't have enough oxygen.
It is not east to notice this condition, unfortunately. That is why preventing it plays as significant a part as fixing it does. Scientists are still trying to find the causes, but there are a few theories on this. To both cure and prevent these threats to the organism itself, check out these remedies to improve the health of your blood vessels.
Causes and Dangers
Atherosclerosis – the other term for clogged arteries. It is a crucial and overwhelming disease that it's actually the number-one disease in America, followed by cancer. It's surprising, right? The reason is that it is, in fact, a 'silent killer. It's hidden deep inside the body, inside arteries even, which makes it extremely hard to detect. There is simply no medical procedure that can correctly and thoroughly assess the state of your arteries. Still, even if you regularly go to the doctors, this condition rises slowly making it difficult to discover.
No one knows the real reason. What researchers do know is that clogged arteries might be influenced by:
- heavy smoking;
- high cholesterol or hypertension;
- an improper diet rich in fatty foods.
At the beginning, arteries are strong, flexible, and elastic, but eventually this changes. All the cholesterol and calcium we introduce into our bodies builds up along the arteries' walls and inside them and forms the plaque. This is basically a fatty deposit, in the shape of a clot that plugs out the flowing of the blood.
The worst aftermath of either the damaging of the vessels' walls or of a clot forming inside the carotid is the very much feared heart attack. It starts with severe pain in the chest, called angina, and it's known under the medical term coronary artery disease. But, the heart attack is only the number one danger of clogged arteries.
Afterwards follow the strokes. Blood is prevented from reaching the most important organs in the body, so when the heart doesn't receive enough blood, you get a heart attack. When the brain doesn't get its share, you have a stroke. Our necks are full of arteries going directly to the brain.
Aftermath number 3 is severe leg pains, as blood fails to feed your peripheral circulation pathway. This particular disease caused by clogged arteries is called peripheral arterial disease. Naturally, it can be treated, and it only manifests itself via pain when walking. This is why resting appears to help a lot. However, there are certain situations in which the disease gets worse than that. The cells tissues die causing the limbs to be amputated, as there is no other alternative.
Read some of the certain 'usual suspects', so to say:
- Smoking;
- Not enough physical exercise;
- Excessively drinking alcohol;
- Consuming fatty foods or foods rich in saturated and trans fats, such as fast food, deeply fried chicken, ice cream, egg yolks, butter, sour cream, cream cheese, pastries, breaded fish, or chicken, and chips. Try and avoid eating these on a regular basis.
Clogged Arteries Symptoms
There is also another bad news – most of the signs are silent. More often than not, patients find out they have or still have clogged arteries after they've had a stroke or a heart attack. However, there are still some signals you can watch out for, no matter how small – watch out for them in order not to become a victim of clogged arteries.
Calf pain
Claudication – this is the term for this pain. It comes from the Latin term claudicare, which means to limp. As mentioned in the beginning, the disease causes arteries all over the body to clog, including the ones in your legs. So, this makes walking and/or standing more difficult.
Go to the doctor as soon as possible if you feel this pain, since if it has reached to the point where your clogged arteries are causing muscle pain and don't allow walk anymore, you might be in a degraded state of health. The physical check-up or test is not painful at all, as the doctor needs only to check the pulses in your leg, and blood pressure and flow in that area, too. Another important factor why you should immediately go to the doctor is the idea that, if detected early, there will be no need for surgery or even medication as a treatment so that you can right this wrong. The doctor can give you a healthy diet and can give you tips on exercising. By this, you will prevent even greater damage.
Small signals
Some small signals let you know it's time you did something about those clogging arteries. You need to pay attention to them so that you can identify your disease.
- Shortness of breath – happens due to the plaque in your arteries; there isn't enough blood for your heart to pump into your body anymore. Not enough blood means insufficient oxygen, especially towards your lungs. Can lead to intense fatigue;
- Abnormal changes in your legs – these changes can include the loss of hair on your feet, the discoloration of your toenails and the skin itself, coldness of the feet even if it's warm or you're wearing socks, numbness, and tingling;
- Sweating, especially during the night-time – if you sweat a lot, especially if you are in a cold room and at night, it means your heart might be working harder to pump blood into the body and its clogged arteries. However, a doctor's opinion should be asked for, since over sweating can also mean you are menopausing, suffering from stress, deficiencies in your nutrition, obesity, or even anxiety.
This is how nature tells men to watch out after their arteries. A study performed on 37 000 men, all of which were suffering from severe baldness located on top of their head, predicted clogged arteries at any age.
Another study, performed on 7000 people out of which 4000 were women showed that moderate and acute baldness does double the risk of developing a heart disease or having a heart attack at some point. This all means that any sign of hair loss should convince you to pay your doctor a visit and discuss the possibility of clogged arteries. So, women are not excluded, as well.
The ear crease
This sign has made its way into medical research journals. It has been a silent sign of clogged arteries for some decades now. They speak of an angled crease in the ear lobe that crosses it diagonally from the inner canal down to the edge of the lobe itself. Studies show that this crease is an abnormality since the ear lobe should be smooth and that poor circulation causes it. Arteries that ead to the heart are very suspicious in this case.
Medical researchers argue about the ear lobe crease – some say it's merely a sign of aging. Still, no further than last year, scientists have used CT scans to measure silent signs of the clogged arteries syndrome and they found that the infamous ear lobe crease did indeed predict the disease. That happened even in individuals who had already had other causes, such as an unhealthy diet or heavy smoking.
Erectile dysfunction
Men have a system that warns them they might be silently suffering from the clogged arteries syndrome. Erections require a flood of blood going directly towards the penis. This is why when a man has trouble or even finds himself unable to have or sustain an erection, he should immediately pay visit to the doctors.
There are proofs between the two diseases and it is believed there are some three years between them. This means that, in most patients studied so far, clogged arteries were undoubtedly discovered three years after they were diagnosed with erectile dysfunction. The pelvis area is rich in arteries, therefore, if they clog, they will prevent the proper amount of blood reaching the penile zone. Another good thing about this natural warning system is that it also solves the dilemma of the blue pill. Check whether you have clogged arteries before taking the pill.
Home Remedies for Clogged Arteries
There are simple and natural home remedies we can try either to keep our clogged arteries in check or to reduce the symptoms we're feeling. Some of them may even reverse the condition and cure you.
– Pomegranates
One of the most delicious fruits of all that will help not only with your cholesterol levels, but with many other problems you might have as well. This remedy has antioxidants and promotes the body's natural production of nitric oxide. It's found in the blood, and it's the chemical that opens up your arteries and regulates the pressure. To get the best out of these red natural miracles, eat one or two every day or drink a tall glass of freshly extracted juice once per day. Although a real 'silent killer', clogged arteries and all their implications can, as you have seen, be both prevented and cured. Fortunately, there are many solutions to do so, a great deal of them being natural and easy to procure. There is no need to turn to a surgical procedure if you use them. Just change your diet, make it healthier and don't forget to frequently go out for walks.
– Red Yeast Rice
A substitute for white rice reduces the risk of clogged arteries and helps you avoid a heart attack and it's rich in monacolins, which are known to minimize levels of LDL cholesterol. It's also chock-full of minerals, phytosterols, isoflavones, beta-sitosterol, stigmasterol, and campesterol. Red yeast rice can be cooked just like you would usually cook a serving of white or brown rice. You can also buy red yeast rice supplements. The appropriate dosage is considered to be 1200 mg twice per day. Do consult your doctor or your nutritionist before taking these supplements. Just in case, to see whether they are a real match for you.
– Increase your spice-and-herb intake
If you take these spices just increase your intake, as they really do work miracles when it comes to clogged arteries. If you don't, try and include them in your diet.
- Ginger has gingerol and shogaol, two compounds which are known to benefit the cardiovascular system. You can drink ginger tea every day or munch on small pieces whenever the mood strikes;
- Garlic relaxes the blood vessels, as proven by a study performed in 2007 at the University of Alabama. It also lowers cholesterol levels and reduces the biggest risks of all, those of heart attacks and strokes;
- Fenugreek seeds are rich in saponins, yet another natural element that helps in your ongoing battle against clogged arteries. You need to soak the seeds in water overnight. In the morning, drink the whole concoction on an empty stomach;
- Cayenne pepper is spicy and delicious but did you know it's healthy as well? Its hotness and healthiness are provided by the same compound that goes by the name of capsaicin. It improves blood circulation overall and reduces cholesterol;
- Turmeric is very high in curcumin, a component that has anti-inflammatory and antioxidant qualities to it. This basically means it will keep blood clots from happening altogether.
– Change the way you live
Change the way you live. It doesn't have to be a drastic change, just include half an hour or more of leisurely strolls outside, picking up a light sport, such as badminton or giving up junk food for a healthier diet. The way you eat doesn't have to change drastically either. You can simply replace sugary drinks with freshly squeezed juices, and eat more vegetables and fruits. Also, make sure you sleep enough and don't be afraid to stand up and go out, whatever the reason.


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Samsung Electronics expects first quarter profits to drop by more than 30%, marking the sixth straight quarterly decline at the company, which is struggling to compete with Apple at the top of the smartphone market.
Operating profit for the quarter will be around 5.9 trillion won ($5.4 billion), a drop of just over 30% versus the first three months of 2014, while revenue is expected to be 47 trillion won, down 12 percent, the company said in its earnings guidance. It will report its full quarterly results at the end of the month.
The profits outlook isn't as bad as analysts had feared.
Samsung, long the king of the smartphone market, is facing stiff competition at both ends of its business. At the low-end, a new wave of low-cost Chinese smartphone makers like Xiaomi are taking away market share, while on the high-end Samsung is locked in a fierce battle with Apple.
For several years, Samsung led sales in the market by offering large screens -- something Apple stubbornly refused to adopt -- but that changed with the iPhone 6. Apple offered two versions of the phone with large screens and consumers loved them.
The iPhone 6 became the best phone launch in Apple's history and unseated Samsung at the top of the market, according to an estimate by Gartner. Apple sold 74.8 million phones in the fourth quarter against Samsung's 73 million, Gartner said.
That's why the Galaxy S6, which goes on sale this week, is particularly important for Samsung.
In designing the phone, the company has moved away from the black plastic it has traditionally used and turned to glass and metal, much like the iPhone. One version of the S6 has a screen that curves at the edge -- a distinctive feature. The phone has received wide praise from reviewers but it's too early to know how consumers will react.
Samsung's semiconductor business is enjoying growing profits thanks to increased demand for DRAM memory chips. Samsung is also the world's largest manufacturer of high-speed DDR3 DRAM chips, which are used in phones, personal computers and servers.


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Orecchiette Pasta With Broccoli Rabe and Limoncello
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Recipe by dicentra
Another one from Barton Brands. Orecchiette means "little ears".
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Ingredients Nutrition
- 1 (16 ounce) package orecchiette
- 1 1⁄2 cups reserved cooking water, from the pasta
- 1 bunch broccoli rabe, washed and chopped into 1-inch pieces
- 4 tablespoons extra virgin olive oil
- 6 garlic cloves, cut into thick lengthwise slices
- salt and pepper
- 1⁄2 teaspoon crushed red pepper flakes
- 2 teaspoons fennel seeds
- 1⁄4 cup caravella limoncello
- 2 tablespoons chilled butter, cut into thin slices
Directions See How It's Made
- Cook the orecchiette according to the package directions.
- About a minute or two before the pasta is cooked, stir in the chopped broccoli rabe. Before draining the pasta and broccoli rabe, reserve 1 ½ cups of the cooking liquid.
- If you place a measuring cup in the colander set in your sink, it will serve as a reminder to reserve the cooking liquid.
- After reserving the 1½ cups of cooking liquid, drain the pasta and broccoli rabe.
- Return the drained pasta and broccoli rabe to the empty pot and set on the stove, but don't turn on the burner under it. Heat the olive oil in a medium skillet over medium heat.
- Add the garlic, salt and pepper to taste, the crushed red pepper flakes and the fennel seeds. Cook for about 2 minutes, stirring until just golden brown but not burned.
- Add the Caravella Limoncello and the reserved cooking liquid. Cook at a low-medium boil, stirring occasionally for 1 minute.
- Turn the garlic mixture into the pot of pasta and broccoli rabe and stir to combine.
- Scatter the slices of butter over the top and stir to mix well until the butter melts and the sauce looks creamy. Add salt and pepper to taste. Serves 4-6.


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The atmosphere is set for a family or a couple wanting to enjoy great home cooked meal. Service is very personable.
We were happy to find this after finding our first choice overcrowded. When we got here we were seated quickly and received excellent service. The food choices were nice and the food was good. T...
Levering Cafe is located at 5707 N MacKinaw Hwy, Levering, MI. This business specializes in Restaurants.
Visit Levering Café and you`ll get a leisure restaurant that serves up American cooking. Expect the average entrée to cost under $8.
Details to Note: Carryout is available.


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Earlier in the day, it had been reported that New York Jets top cornerback Dee Milliner had suffered a high ankle sprain during Sunday's practice and would need to miss a few weeks to rehab the injury.
The few weeks now, is at least three to four weeks, as Ed Werder from ESPN reported on Monday, which means he will be out for the rest of the preseason trying to recover from the injury
I'm told #Jets expecting that CB Dee Milliner will be out 3-4 weeks, a timeframe making it close for the #NFL season-opener against #Raiders— Ed Werder (@Edwerderespn) August 11, 2014
Not only will Milliner be out for the rest of the preseason (which obviously means he will not be playing on Saturday night for the Jets against the Cincinnati Bengals,) but now, his status for Week 1 against the Oakland Raiders is in doubt as he's already being listed as questionable.
Dee Milliner's availability for Week 1 vs Raiders (Sept. 7) is in serious doubt. Jets trying anything and everything at cornerback. #nyj— Manish Mehta (@MMehtaNYDN) August 11, 2014
With Milliner's injury, along with Dexter McDougle tearing his ACL and be forced to miss the entire 2014 season and Dimitri Patterson dealing with injuries, it has utterly depleted the Jets secondary heading into the rest of training camp and the preseason and it's also why the Jets have reached out to current free agent and former Philadelphia Eagles and Atlanta Falcons cornerback Asante Samuel.
Milliner was seen at Monday's practice wearing a boot on the foot and the team was unable to get Milliner an MRI on the ankle because as Manish Mehta of the New York Daily News reported, Jets head coach Rex Ryan said that the ankle was too swollen to do such a thing.
Rex Ryan says Dee Milliner's ankle is too swollen to get an MRI at this point #nyj— Manish Mehta (@MMehtaNYDN) August 11, 2014
The Jets reported interest in Samuel could kick up a notch after their game against the Bengals pending on how the healthy cornerbacks they have on the team play in Cincinnati this week.
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Tags: Dee Milliner, Football, New York, New York Jets, NFL


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Mysterious Universe brings you the latest news and podcasts covering the strange, extraordinary, weird, wonderful and everything in between.
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May 6th, 2016
Episode 86 of 144 episodes
Researchers Steven and Evan Strong join us to discuss their latest book 'Between a Rock and a Hard Place',why they believe the Out ofAfrica theory is incorrect, and howAustralia is the true cradle of humanity. We also feature the latest research from the Institute of Noetic Sciences, the pill that can remove fear, and new case files of Russian USOs. Sponsors Squarespace - Use the code MU at checkout for 10% off Alarm.com - Visit Alarm.com/mu for smarter home security today! Steven & Evan Strong Out of Australia Theory: Steven & Evan Strong's New Theory of Human Civilisation Between a Rock and a Hard Place: The Out of Australia Theory Shunned Links I See Dead People: Can Mediums Tell If Someone is Alive or Dead From Just a Photo of Their Face? Prediction of mortality based on facial characteristics Bhutan's Dark Secret to Happiness The Cure for Fear Plus+ Extension The extension of the show is EXCLUSIVE to Plus+ members. To join, click HERE. Russia's USO Secrets: Unidentified Submersible Objects in Russian and International Waters UFO Case Files of Russia Going to the toilet can be like having an ORGASM - doctors say 'poo-phoria' is a real thing An 'angel' locals believed fell from the sky turns out to be a sex toy Music Mr. Carmack - Pay For What Alexander Lewis Trombone Flipvia First Ear The Detroit Experiment - Think Twicevia Noonday Tune iamyank - No Air via BeeHype Gerd - Planet F.M.D.X. pt. 1 - Clone Royal Oak 034 via XLR8R Zanski - Into Youvia Pan od Muzyki KAYTRANADA - BUS RIDE (W/ Karriem Riggins & River Tiber) via XLR8R
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Welcome to the Brain Training Podcast, the daily audio workout for your head. In this podcast we have two games for you, each with three rounds which get progressively harder. To enjoy the full experience, relax, and avoid distractions whilst you listen.


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RainShadow Labs has been refining "skin refining" products for more than thirty years now. Facial masks are the icing on the cake when it comes to product line ups. After you have dialed in your lotion and serum and cleanser and toner, the mask is what finishes off all of your positive efforts regarding your skin. Masks are the "finisher" when it comes to your face.
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Seattle and Texas are looking for offense and both teams have expressed interest in one or more of the available Dodgers outfielders.
ORLANDO, Fla. -- The Mariners and Rangers are two teams to express interest in one or more of the available Dodgers outfielders.
Los Angeles, with four talented outfielders, has told teams it will listen to offers for Matt Kemp, Andre Ethier or Carl Crawford. It also has Yasiel Puig, the NL Rookie of the Year runner-up.
The interest on the part of Seattle and Texas shouldn't be seen as a surprise. Seattle was the one team known to have strong interest last winter in Ethier, though the Dodgers never really made him available then. The Rangers need to replace free agent Nelson Cruz's offense in some way.
Rival teams have suggested the Dodgers would have to pay down at least a part of the trio's contracts to make a trade, but in this cash-rich market, that isn't a certainty. Kemp has a $160 million, eight-year deal, Crawford $142 million for seven and Ethier $85 million for five.
The Mets have an obvious outfield issue but to this point have shown little interest in the Dodgers triumvirate.
Kemp would seem to be the hardest to trade because his value is less known now. At his best, he's one of the best players in the game, but he's coming off two surgeries. He also is a center fielder, though Ethier was passable as a replacement last year.


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Acosta Sales & Marketing Demo Brand Ambassador - Pet (Weekend) in Lubbock, Texas
The Brand Ambassador – Pet promotes sales through education of specific vendor products and communicate product benefits.
Click here
to view a short video about "A day in the life of a Demonstrator for Acosta".
Promote sales through education of specific vendor products.
Communicating product benefits.
Identify selling opportunities. Talk to customers about their pets, and their pet's needs, provide solution with representing vendors' product.
Identify competition and any significant changes in pricing, promotion and volume.
Provide and Set up product display tables.
Implement and distribute IRC's point of sale materials.
Other miscellaneous duties assigned.
1-3 years of sales experience.
Outgoing good communicator.
Must be able to stand for 4 hours.
Must have table to set up at store.
Must have computer at home.
Acosta Sales & Marketing is an Equal Opportunity Employer
Job ID 2017-127553
Work City Lubbock
Work State US-TX
Position Type Regular Part-Time
Work Zip 79407
Starting average hours per week < 20
Category Field Jobs


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The Secret Swapper | The Powerpuff Girls | Cartoon World
The Powerpuff Girls come across a powerful fortune-telling device known as the Secret Swapper.
Welcome to CartoonWorld! Enjoy clips of cartoons from: Bunnicula, The Powerpuff Girls, Teen Titans Go!, Tom and Jerry, We Bare Bears, Wabbit, Peanuts, Oddbods, Supernoobs and more!
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