text:
McCarthy is expected to reteam with 'The Heat' director Paul Feig, while Matthew Vaughn shows interest in casting Watson for his next pic.
Casting news surrounding two 20th Century Fox agent movies has hit the web. First off, The Wrap learns that Paul Feig wants to reunite with Melissa McCarthy for the third time. After "Bridesmaids" and "The Heat", McCarthy enters negotiation to star as a female spy in comedy "Susan Cooper", which will be directed and co-written by Feig.
In other news, Variety reports that director Matthew Vaughn has an interest in getting Emma Watson attached to play in his latest movie "The Secret Service". Vaughn also reportedly considers "Dark Shadows" actress Bella Heathcote if the Nicki of "The Bling Ring" eventually does not make it as Colin Firth's female co-star.
Feig, whose latest movie "The Heat" has performed well at the box office, has been confirmed to develop "Susan Cooper" since last month. The pic was inspired by the reintroduction of James Bond in 2006's "Casino Royale", which turns out to be one of his favorite movies. The 50-year-old helmer also hopes that it can be a franchise for Fox.
Meanwhile, Vaughn began developing the adaptation of Mark Millar and Dave Gibbons' comic back in 2011. "This is James Bond meets My Fair Lady," Millar said of the story to The Hollywood Reporter in April 2012. Recently, newcomer Taron Egerton has been on board to be the nephew whom Firth's character mentors to become a secret agent.
McCarthy and Watson's upcoming movies, "Tammy" and "Noah" respectively, are already in post-production. Both are set to be released in 2014.


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All About Roald dahl
by: Jackson gordon
Table of contents
1.Who's Number 1! No, really......
2.first paragraph graphic organizers
3.gremlin comparison
4. So So happy... or is it?
5. second paragraph graphic organizer
6.Charlie and the chocolate factory intro song
7.He's so smart where did he go to school?
8. third paragraph graphic organizer
9. Roald's birth place
10. cite page
1.Who's Number 1! No, really......
Most people wonder what Roald Dahl's first book was and what is was about. You are probably thinking Matilda or Charlie and the great glass elevator, well you're are wrong. His first book was actually the children's story The Gremlins. I know what you're thinking, he doesn't write movies and that's a horror movie not a book. Well the green goblins that you can't feed after 12 or put in water have nothing in common. The original story was about little monsters that lived on bomber and fighter planes and were the cause of all crashes. All of a sudden people started saying gremlins here and there and it became it's own saying, have you ever heard someone say this computer has gremlins(computer can be replaced with cars, games and machines in general). This story also became a movie except this one is more child friendly as it was made by Disney(at the bottom I'll show a comparison of the two creatures one from each movie). Roald actually wrote the book by taking an event from his life and taking the sorrow out of it. What happened was, during World War II he crashed in the middle of the desert and was later found. After the crash he started to write about the adventures he had (but that's for another article) which were published in various magazines. Each story got more and more silly and he finally wrote a full book instead of magazine articles. The Gremlins was his first book. Imagine what inspired Charlie and the Great Glass Elevator read the next article to find out the real story behind this and a few other books.
4.So So happy... or is it?
The truth behind those imaginative and fantasizing stories have some pretty dark inspirations. Let's start with Charlie And The Great Glass Elevator, a story about a poor kid winning big in a contest for candy. This is what's behind it (anything in between these() is about the book). As a kid when Roald's father died the family couldn't hold things together and started to lose money, thus Charlie is poor. In school Roald started meeting some pretty mean and sick people who became Augustus, Violet, Mike and the other characters in the book. Every time Roald would get a small amount of money when he was a kid, like when Charlie finds the coin, he would spend it on his only get away,candy, this was his golden ticket. Now you probably expected some happy tale, well things just didn't work that way for Roald. Next, Matilda the girl who was a genius but was abused by many, this story was also inspired by Roald's childhood experiences. He had started in one school for kindergarten which he loved, and Matilda loved her kindergarten teacher. He changed schools because of his father's dying wish that he attend English schools, and Matilda had to go to fifth grade because she was too smart for kindergarten. At the new school he met friends that he could rely on, and Matilda stayed friends with her old teacher. He then realized that the principle was a horrible person and Matildas principle was crazy too! Roald was severely beaten and left that school, Matilda was abused by her parents and her teacher found the deed that allowed her teacher to take custody of her. Now I think you can see that the happy faces you can see in the music video below, from the Charlie and the Chocolate Factory movie, don't always look that way behind them.
7.He's so smart where did he go to school?
As a kid school wasn't a good place for Roald. It started when his sister died of appendicitis, this caused his dad to get very depressed and he eventually died, his dying wish was that Roald attend a proper English school. Soon after his father's death his mother sent him to Llandaff Cathedral school. There he made many friends, but friends turned out to be a bad thing, him and his "friends" put a dead rat inside a candy jar at a store. Now you would get grounded and pay up money to replace things , him and his buddies got severely beaten by their principle who had no reason to punish them. His mother, full of concern, sent him to St. Peters boarding school and later Repton, a prestigious private school. Whenever his mom asked him where he wanted to go to college he replied "nowhere, as soon as I'm done I'm going to go work for a big corporate company that will send me to places like China and Africa." Once he really finished, he went to work for Shell Oil company , but because of World War II he lost his job due to the oil shortage. So he decided to be a pilot in the war until it was over. He ended up crashing in a deser, luckily he was found and survived. Soon enough he started to write about all these crazy events turning them into the stories we know and love.
Roald Dahl's birthplace
thanks to these cites and books for information
Dahl, Roald, and Quentin Blake. Boy: Tales of Childhood. New York: Puffin, 2009. Print.
Lombardi, Esther. "Roald Dahl Quotes." Books & Literature Classics. N.p., n.d. Web. 17 Dec. 2014.
"Roald Dahl Facts, Information, Pictures | Encyclopedia.com Articles about Roald Dahl." Encyclopedia - Online Dictionary | Encyclopedia.com: Get Facts, Articles, Pictures, Video. N.p., n.d. Web. 17 Dec. 2014.
"Roald Dahl." Infoplease: Encyclopedia, Almanac, Atlas, Biographies, Dictionary, Thesaurus. Free Online Reference, Research & Homework Help. — Infoplease.com. N.p., n.d. Web. 17 Dec. 2014.

subset: commoncrawl


text:
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text: Rhythm Therapeutics, Inc. (RTI) technology is expected to significantly improve upon the current low success rate of current ablation strategies in treating atrial fibrillation (AF). The company is pursuing a proprietary utilization of gene therapy to target key mechanisms causing AF. This gene therapy will be delivered to the heart via a minimally invasive, IP-protected approach.


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Lasagna With White and Red Sauces
Be the first to review
READY IN: 1hr 20mins
Recipe by AmyZoe
A new variety to an old classic. I never thought of combining these ingredients in my lasagna, and I wasn't disappointed. I used Ricotta in place of Bel Paese cheese--feel free to use cottage cheese or whatever your heart desires. Recipe courtesy of 101+ Hurry Up Hamburger Recipes.
See Discussion:
Ingredients Nutrition
Bechamel Sauce
- 29.58 ml butter
- 29.58 ml all-purpose flour
- 177.44 ml milk
- white pepper
- 1 medium onion, sliced
- 1 garlic clove, minced
- 29.58-44.37 ml vegetable oil
- 453.59 g lean ground beef
- 793.78 g crushed tomatoes (or whole tomatoes, chopped and undrained)
- 118.29 ml celery, thinly sliced
- 118.29 ml carrot, thinly sliced
- 4.92 ml dried basil, crushed
- 453.59 g lasagna noodle, cooked and drained
- 170.09 g bel paese cheese, thinly sliced
- 6 hard-cooked eggs, sliced
- 29.58 ml butter, cut into small pieces
- 236.59 ml parmesan cheese, freshly grated (or Grana Padano Cheese)
Directions See How It's Made
- Prepare Bechamel Sauce first: Melt butter in small sauce pan over medium heat. Stir in 2 tablespoons all-purpose flour. Gradually blend in 3/4 cup milk. Season to taste with white pepper. Cook until thick and bubbly, stirring constantly. Set sauce aside.
- Cook and stir onion and garlic in hot oil in Dutch oven over medium-high heat until tender.
- Add ground beef and cook until no longer pink, stirring occasionally.
- Add tomatoes, celery, carrot, and basil.
- Reduce heat to low.
- Cover and simmer 45 minutes.
- Remove cover and simmer 15 minutes more.
- Arrange 1/3 of the lasagna noodles in bottom of buttered 13x9 inch baking dish.
- Add 1/2 cup of the Bel Paese cheese (I used Ricotta instead) and 1/2 of the eggs.
- Spread the Bechamel Sauce.
- Top with layer of noodles.
- Dot with butter.
- Sprinkle with Parmesan and bake in preheated 350 oven for 30 to 40 minutes or until heated through.
- Let stand 10 minutes before cutting.


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Assistant men's basketball coach Nate Pomeday sometimes forgets whom exactly he's working for at Oregon State.
It's not that his memory lapses that Craig Robinson is his boss and the coach of the Beavers. But between running around the country recruiting with Robinson, discussing basketball strategy with him and seeing him act no different from your ordinary coach on a daily basis, Pomeday isn't being constantly hit over the head with who Robinson and his family are in the grand scheme of things. It's not as if Robinson brags about who he has in his cell phone.
"At times, I forget how intertwined he is with what is an amazing, amazing story in the history of America," Pomeday said. "It's unbelievable. His family is writing the history books. I forget that, and then I turn on CNN. 'Holy cow, his sister is on TV.'"
Robinson, 47, is the older brother of first lady Michelle Obama and the brother-in-law of President Barack Obama.
Although life around Robinson and his entire family has changed significantly in the past year, Robinson himself hasn't. Those who knew him before he ever spoke at the Democratic National Convention or had a front-row seat to the presidential inauguration attest that the Chicago native is still that hardworking, caring and honest person he always has been.
"I'm 55 years old, and even now when I have a hard decision to make, you know who I call? Craig Robinson," said Johnnie Gage, who coached Robinson as a kid. "He still answers his phone for me."
Robinson's famous relatives certainly didn't matter to Ahmad Starks and his family when they started planning a college future. They realized Barack Obama wasn't going to be the one calling timeouts for Oregon State.
"It had nothing to do with Barack," said Starks' father, Don. "Craig Robinson was more intriguing to us."
Robinson did have an in with the family, though. He knew Don from the 1990s, when both worked in the business world. He also knew the younger Starks because Robinson's son had played sports with Ahmad.
Despite their previous relationship, Robinson still had to sell Starks on Oregon State like any other recruit. After taking in each school's pitch, the Starks family sat down with a pen and paper, attributed points to specific categories and added it all up. In the end, the Beavers came out on top.
Oregon State provided a high level of basketball in the Pac-10, excellent academics and a coach the Starkses could trust.
"At the end of the day, do you trust them?" Don said. "Do you believe someone is going to take care of your son to grow as a man? We trust Craig. We knew his background and character. He's a great, great person. He's honest, and he's about helping kids, helping people."
Ahmad was just as sold on Robinson's personality.
"He's a laid-back person, kind of like myself," said Starks, who, as a junior guard, helped Whitney Young to a state championship. "He can be funny. He's just a good person to be around. He knows how to get to people."
A lot of coaches don't enjoy recruiting. Even fewer are good at it. Robinson found himself to be that rare one who enjoyed it and was good at it.
It goes back to when he wore a suit and tie to a different sort of occupation. He spent time as the vice president for Continental Bank, a VP for Morgan Stanley Dean Witter and finally as a managing director for Loop Capital Markets.
"Recruiting is like sales and marketing," Robinson said. "If you spend 14 years in the business world, you can't do that without knowing something about marketing. How to market yourself, how to market your product, how to market your company. Recruiting is sales. It's the lifeblood of your program. Just the same as sales is the lifeblood of a company."
Robinson felt something missing in his life while working behind a desk. It wasn't the money. That was one upside to it all. But the corporate world just didn't satisfy him in a way that basketball had always done.
"I had been fortunate to be in a career where you could fulfill your goals and set up yourself in a good way financially," he said. "What I realized was I wasn't having any fun in what I was doing. I realized what I really loved was teaching and coaching."
In stepped former Princeton and current Northwestern coach Bill Carmody with the offer of an assistant coaching job with the Wildcats. Robinson, who had played at Princeton, had to consider whether the loss of income would be worth it to his family. When his family members assured him they'd be happy no matter what, he took the job in 1999.
Robinson quickly found coaching was no different from his previous occupations in some ways. Both were stressful, but he found the stress of coaching to be easier to absorb.
"I just enjoy the job and the lifestyle and being a part of a kid's life," he said. "You feel like you're doing more."
The one question he had for Carmody in the beginning of his tenure was whether the veteran coach thought Robinson was too old to be a head coach himself one day. Carmody didn't think so, and he was proved correct when Robinson was hired as the Brown head coach after six seasons with the Wildcats.
Robinson spent two years at Brown, leading the Bears to a school-record 19 wins and a College Basketball Invitational berth in the 2007-08 season. After his second season, Oregon State came calling.
Oregon State wasn't exactly a dream program to take over.
The year before, the Beavers had gone winless in 18 Pac-10 contests and won a total of six games. Their season ended on a 20-game losing streak.
"There were obstacles aplenty," Robinson said. "The first obstacle was me. They had to learn how to manage me and what I expected. Just everything from work habits to behavior on and off the court. Basically, how to get better every day."
To many people's surprise, Robinson had the Beavers' sinking ship back afloat in just one season. OSU went 18-18 and had the country's third biggest win improvement. The Beavers also won seven conference games, swept California and Stanford, and ended the year by winning the CBI in a best-of-three series with UTEP.
"I would be lying to you if I thought we would have been as successful as we ended up being," Robinson said.
Recruiting the Chicago area is nothing new to Robinson. He's just doing it from farther away than before.
At Northwestern, he brought in players from the Chicago area. At Brown, he did the same. Already, that trend is continuing at Oregon State.
In the Beavers' 2008 recruiting class, Robinson received a letter of intent from Lake Forest Academy's Angus Brandt. Brandt and Rhys Murphy, who also signed with Oregon State, played club basketball with Chicago suburban-based Full Package Athletics. Starks is committed for 2009. Whitney Young's Sam Thompson, Class of 2010, and Glenbrook North's Alex Dragicevich, Class of 2009, have mentioned Oregon State among the schools they're considering.
"The good thing about big cities like Chicago, Los Angeles, New York is there's a lot of good basketball players," said Robinson, who is always sure to stop at Lem's Bar-B-Q House on 75th Street whenever he's back home. "Clearly, Chicago has a warm spot in my heart because I'm from here. The older I get, most of the guys who are coaching in Chicago I've coached against them or played them sometime in my career."
Illinois Warriors coach Larry Butler and Full Package Athletics coach Steve Pratt are among those who have dealt with Robinson for many years. Both have always been impressed.
"Parents are going to listen to him when he comes through the door," Butler said. "Craig is a smart guy. He's a good recruiter."
"I love Craig," Pratt said. "Craig's a straight shooter. He's a tough coach. He's going to make you tough. But he's also a players' coach. He's looking to develop players."
To help in his Chicago recruiting mission, Robinson hired Pomeday to his staff last summer. Pomeday, a former Northwestern player, spent time coaching at Lake Forest Academy and Full Package Athletics. Both were in Deerfield in early July to recruit at the Chicago Summer Classic.
Of course, there's also the fact that Robinson is the brother-in-law of the president and Obama has declared he's an Oregon State basketball fan.
"He's closer to Barack Obama than 99 percent of the rest of the world," Dragicevich said. "There's a cool factor to that."
Pomeday believed there was another factor to it, as well.
"I think there's an advantage in a way in parents know we automatically have credibility as far as character and how we're going to treat our kids and how we act," Pomeday said. "Everything we do is under a microscope whether we like it or not."
Robinson said, "There's much more scrutiny. I'm not using that word as a negative. More people are playing attention. We want people paying attention."
Character is the word most associated with Robinson.
For Robinson, it's a word he associates back to his parents, Fraser and Marian Robinson, as he grew up on Chicago's South Side.
"They laid a very good foundation for success," Robinson said. "Teaching me and my sister how to behave, how to go about our business, how to love, building a base of fundamentals."
That discipline continued with his earliest basketball coaches and later when he attended Mount Carmel, an all-boys Catholic high school. In May, he was inducted into Mount Carmel's hall of fame.
"There was an accountability, which I love," Robinson said. "You were supposed to do your homework, and if you didn't, there were repercussions. You were supposed to behave in the hallway, and if you didn't, there were repercussions."
The coaches who have influenced Robinson's career have ranged from those at Mount Carmel to Princeton's Pete Carril to Carmody. One of the earliest was Gage, who coached him at the Martin Luther King Jr. Boys Club in Chicago.
In the 1970s, Gage possessed an AAU team that would make any coach jealous.
Alongside Robinson in the starting lineup, Gage played Mark Aguirre and Isiah Thomas. As expected with three future NBA draft picks -- the Sixers drafted Robinson in the fourth round in 1983 -- the team rarely lost. In the six years Gage coached the boys, he estimated they lost six, maybe seven games.
More important than dominating the competition, though, Gage thought he got through to Robinson on a different level. It might explain why Robinson still always answers Gage's phone calls.
"What I told those guys was by the time you're 36-37 years old, basketball is over," Gage said. "If you don't have an education, don't have the right mind, haven't been around the right people, around the right management, you're back at the start. Those kids listened to me, and they made it.
"I always say birds of a feather flock together. Craig Robinson and his sister, Michelle, look who else they hang around with -- Barack Obama and people like that. If my son was playing basketball and was able to go to a school that Craig was coaching, and he would be the last person on the bench, and he could start at any other university, I'd tell him to play for Craig. Just to be around him, you'll end up being a decent person. Anyone around him is not going to be bad. He's different. He's more different than anybody you can meet, I'm telling you."


text:
So I maintain an online dating profile. It is very well fleshed out and makes very clear I'm only interested in a long term relationship. About 2 weeks ago, a guy in CA messaged me. I am no where near CA. I was somewhat intrigued, as he clearly wasn't local, he'd asked me a philosophical question relating to something in my profile, and frankly, was model-level good looking. So I responded. So far everything he has told me has checked out as true, including the fact that yes, he was a model (huzzah for Skype and the internet). He's been very attentive, in fact a bit too much. His compliments and willingness to commit are kinda over the top and premature, and I can't tell if he's just that smitten, a bit immature, or a player with a capital P. It just seems "too good to be true". He's a doctor (he's older than I am), and so well-off he tells me. He only admitted it reluctantly when I said I wasn't really interested in long distance, and he said travel wasn't an issue for him, that he'd fly out on the weekends. I just have a hard time believing it. Like I said though, it ALL checks out with digging. A friend of his contacted me on the dating site saying that he'd never seen this guy so intent so he wanted to say hi and see what the fuss was about. He's not been shy overall with personal details, which I'd expect form someone looking for the power trip deception can offer. He has been shy with me a bit though, in the stuttering first date sort of way. We have not met in real life yet. I'm a 24 year old PhD candidate, and while I'm hardly unattractive, I'm definitely not model-level pretty. So I'm somewhat perplexed. At the end of the day though, for all his success, intellect and good looks, he is just another person, so I guess it could be?
So guys, What is your take? Is he playing a game very very well, or is he just an unusually desirable lonely guy looking for love?
Most Helpful Girl
To be honest, it seems kinky/fishy to me. I knew a guy (almost dated that guy) who appeared very interested in me at the very beginning, he messaged me every day and pampered me with his complements and his suaveness. It took me almost two years to realise i could never get him to commit to any serious relationship with though. So if i were in your shoes, i would take it veryyy slow. Dont afraid he would run away because if he is your mr. Right, at the end of the day, he will be there for you... And if you haven't met him face to face, you should and talk to him. I think it may help your instinct. Let's wait and see. Good luck!00|00|0


text:
Safia Abdalla, Northside College Prep class of 2014, has been named a National Winner of the Aspirations Award in Computing from the NCWIT.
Safia Abdalla, class of 2014, has been named a National Winner of the Aspirations Award in Computing from the National Center of Women and Information Technology [NCWIT]. Safia is one of 35 young women from across the nation selected for this honor and the only recipient from Illinois. This caps a three year run for Safia. She won the Illinois State award in 2011, the National Runner-Up award in 2012, and now National winner! She was also recently named as one of the top ten high school computer science students in Illinois by the Illinois Technology Foundation's 50 For Future program.
Safia is evidence that perseverance and determination yield rewards. A significant factor for her winning is her tireless work in supporting other young women in Computer Science through her work with Chicago Girls in Computing, Northside Robotics, and facilitating middle school computing experience around the city. Last summer while visiting family in Sudan, Safia organized a computing workshop for young women from her home village, providing some with their first ever computing experience!
NCWIT is the largest academic and professional organization for women in computing. The award includes a scholarship, travel to the NCWIT national conference, and most importantly mentoring from some of the top women computer scientists in the nation!
Please join the Northside Computer Science Department in acknowledging and celebrating her wonderful accomplishments! Also on Friday, She was also accepted by Northwestern University's School of Engineering.
PS: This makes two years in a row that Northside has been honored with a National Winner. Abril Vela, class of 2014, was awarded the National honor last year!
Don Yanek
Chair: Department of Computer Science, Northside College Prep HS
Chicago Chapter of the Computer Science Teachers Association
Illinois Representative: National CSTA Leadership Cohort


text: SemiLEDs Corporation (NASDAQ: LEDS), will report financial results for the fiscal third quarter ended May 31, 2012, before market open on Tuesday, July 10, 2012. The Company will hold its quarterly conference call to discuss these results at 8:00 a.m. EDT (5:00 a.m. Pacific Daylight Time, 8:00 p.m. China Standard Time). Investors may access a live webcast of this conference call by visiting: http://investors.semileds.com/events.cfm A replay of the webcast will be available on the Investors section of the Company's web site approximately three hours after the conclusion of the call and remain available for approximately 90 calendar days. About SemiLEDs SemiLEDs develops and manufactures LED chips and LED components primarily for general lighting applications, including street lights and commercial, industrial and residential lighting. SemiLEDs sells blue, green and ultraviolet (UV) LED chips under the MvpLED brand.


text:
Nova Spire Ottawa
Nova Spire - Audio Visual Artist based in Ottawa, Canada. Expanding creativity, imagination and consciousness. I create a
diverse array of different electronic music projects. I score and compose music for film and am always excited to take on new projects.
Nova Spire is the major umbrella under which I create music, on occasion I release under different aliases. ... more
Streaming and Download help


text:
|Home | About | Journals | Submit | Contact Us | Français
Staphylococcus aureus pathogenicity islands (SaPIs) are mobile genetic elements that encode virulence factors and depend on helper phages for their mobilization. Such mobilization is specific and depends on the ability of a phage protein to inactivate the SaPI repressor Stl. Phage 80α can mobilize several SaPIs, including SaPI1 and SaPIbov1, via its Sri and Dut proteins, respectively. In many cases, the capsids formed in the presence of the SaPI are smaller than those normally produced by the phage. Two SaPI-encoded proteins, CpmA and CpmB, are involved in this size determination process. S. aureus strain Newman contains four prophages, named NM1 through NM4. Phages NM1 and NM2 are very similar to phage 80α in the structural genes, and encode almost identical Sri proteins, while their Dut proteins are highly divergent. We show that NM1 and NM2 are able to mobilize both SaPI1 and SaPIbov1 and yield infectious transducing particles. The majority of the capsids formed in all cases are small, showing that both SaPIs can redirect the capsid size of both NM1 and NM2.
Staphylococcus aureus is a ubiquitous bacterium that is associated with a variety of clinical presentations.1 The emergence of community-acquired virulent and antibiotic resistant S. aureus strains is a significant public health issue.2 Virulence in S. aureus and other bacteria is often associated with mobile genetic elements, such as bacteriophages, plasmids and pathogenicity islands that are horizontally transferred within the bacterial population.3,4
Bacteriophages are also involved in the mobilization of a family of S. aureus pathogenicity islands (SaPIs).5 SaPIs are 14–27 kb genetic elements that contain phage-like repressor, integrase and terminase genes, as well as genes encoding superantigen toxins and other virulence and antibiotic resistance factors. Two of the best characterized SaPIs are SaPI1 and SaPIbov1, found in S. aureus strains RN4282 and RF122, respectively.5 SaPI1 carries genes for the toxic shock syndrome toxin 1 (tst) and enterotoxins K (sek) and Q (seq).6 SaPIbov1 carries tst as well as sec and sel, encoding enterotoxins C and L, respectively, and is associated with bovine pathogenic S. aureus.7 While normally repressed and stably integrated in the host genome, SaPIs become derepressed and mobilized by specific "helper" bacteriophages. Upon mobilization, the SaPI genomes are packaged into transducing particles formed by structural proteins encoded by the helper phage.8,9
The first step of the mobilization process is the inactivation of the SaPI Stl repressor, which is dependent on specific interactions between Stl and a phage-encoded derepressor.5,10 Bacteriophage 80α, a transducing phage that is closely related to staphylococcal typing phage 53,11-13 encodes a protein, Sri, gene product (gp) of open reading frame (orf) 2211(Table 1) that binds to and deactivates SaPI1 Stl. In contrast, the SaPIbov1 Stl protein, which only shares 16% sequence identity with SaPI1 Stl, does not respond to Sri. Instead, SaPIbov1 Stl is inactivated by binding of 80α gp32 (Table 2), which encodes a dUTPase (Dut).10 A third mechanism is found in SaPIbov2, in which Stl is derepressed by the 80α gp15 protein.10 80α has also been shown to derepress SaPI2 and SaPIn1, by an unknown mechanism.5 Derepression leads to excision and replication of the SaPI genome.
Capsid assembly in 80α, as in other bacteriophages, starts with the formation of a precursor procapsid from the major capsid protein (CP; gp47 in 80α) and a scaffolding protein (SP; gp46)11 that acts as a chaperone for the assembly process.14,15 A ring-shaped portal made of portal protein (PP; gp42) and a few copies of a minor protein of unknown function (gp44), are also incorporated into the procapsid.8,16 The DNA is packaged through the portal in a process that requires the terminase complex, consisting of the small (TerS; gp40) and large (TerL; gp41) terminase subunits. During DNA packaging, the capsid changes from a round, thick-walled procapsid to an angular, thin-walled mature capsid.17
A unique aspect of the phage-induced SaPI mobilization is that in many cases, the capsids formed are smaller (having T = 4 icosahedral symmetry18) than those normally formed by the phage alone17 (T = 7). The smaller capsid can only accommodate the smaller SaPI genome and thus interferes with phage multiplication.6 We previously showed that SaPI1 proteins gp6 (CpmB, Capsid morphogenesis protein B) and gp7 (CpmA) (corresponding to SaPIbov1 gp8 and gp9, respectively; Table 2) are involved in this size determination,16,18-20 and that CpmB acts as an internal scaffold in the T = 4 SaPI1 procapsids.18 CpmA and CpmB are conserved, and always appear together, in the majority of SaPIs sequenced to date.5 Other factors, including the SaPI-encoded TerS subunit, also contribute to phage interference.21,22
S. aureus strain Newman (NCTC 8178) was originally isolated from a case of 'secondarily infected tubercular osteomyelitis'23. It produces more coagulase than other strains23 and is currently used in animal infection models.24-27 The strain Newman genome28 (GenBank ID AP009351) contains no recognizable SaPIs, but harbors four prophages, named NM1, NM2, NM3 and NM4,29 three of which (NM1, NM2 and NM4) could be induced via the SOS response with mitomycin C, and one (NM3), that could not. A phage-cured strain Newman showed greatly reduced virulence, largely due to the lack of NM3, which carries several virulence genes, but the other phages also appear to contribute to the parental strain's virulence.29
Based on sequence comparisons with 80α, we predicted that NM1 and NM2 should be able to mobilize SaPI1 and other SaPIs that are mobilized by the 80α Sri protein. In this paper, we test this prediction, and find that NM1 and NM2 can indeed mobilize SaPI1. In addition, both phages can mobilize SaPIbov1, which was surprising, in light of the extreme differences in the Dut protein. We also find that NM1 and NM2 respond to capsid size determination induced by SaPI1 and SaPIbov1, although in the case of mobilization of SaPIbov1 by 80α, only about 63% of the capsids formed are small. Our results suggest that prophages found in clinical isolates of S. aureus may play a role in mobilization, spread and establishment of pathogenicity islands in the bacterial population, and underscore the importance of prophages in the evolution of bacterial pathogenicity.
S. aureus strain Newman phages NM1 and NM229 were identified in a global BLAST search for bacteriophage sequences related to the 80α CP and SP. The other two Newman phages, NM3 and NM4, are more distantly related to 80α and were not picked up by a BLAST search. The NM4 capsid protein is about 37% identical to those of 80α, NM1 and NM2, while NM3 is not homologous to the other three phages; it is non-inducible by mitomycin C and appears to be defective in excision and lysis.29 NM3 and NM4 will not be considered further in this paper.
The complete genomic sequences of NM1 (GenBank accession number DQ530359),29 NM2 (DQ530360)29 and 80α (DQ517338)11 were aligned using the programs Easyfig30 (Fig. 1) and VISTA31 (Fig. S1). Large tracts of the three genomes are identical, in particular the structural gene cluster starting from terS [80α orf40, nucleotide (nt) number 16,407] until the end of 80α orf69 at nt 40,331 (Fig. 1), which in 80α are all considered to belong to the same operon.11 (See Table 1 for a listing of relevant proteins and their GenBank IDs.) The major capsid proteins (CP) of NM1 and NM2 share 99% sequence identity with 80α CP. The scaffolding proteins (SP) are 68% identical to 80α SP, with all differences clustered in the N-terminal half of the protein (Fig. 2A). Importantly, the C-terminal end of SP, which is thought to be responsible for CP binding,18 is conserved.
Other genes were also conserved (Fig. 1), most notably the genes encoding the SaPI1 antirepressor (Sri) homologs, which exhibit only two amino acid substitutions at the protein level (Fig. 2B). 80α Sri (ABF71593) corresponds to protein ABF73115 in NM2. In the NM1 sequence, the equivalent gene was not annotated, but corresponds to an orf that is found between nt 11,303–11,461 (which lies between ABF73049 and ABF73050; Table 1). This similarity suggested that NM1 and NM2 should be able to derepress SaPI1 by the same mechanism previously determined for 80α.10 Indeed, NM2 (and NM4) were previously shown to mobilize SaPI1.32
The divergent regions of the sequences include numerous orfs that are comparable in size and location to genes in 80α, but are non-homologous. One such gene is 80α orf32, which encodes the Dut antirepressor (ABF71603) of SaPIbov1 Stl.10 According to its position in the genome, this gene corresponds to proteins ABF73061 in NM1 and ABF73127 in NM2 (Table 1). While these proteins are identical between NM1 and NM2, they share less than 15% sequence identity with 80α Dut (Fig. 2C).
Differences between NM1 and NM2 are localized to the two ends of the genome. The integrase (int) gene, at the leftmost end of the sequence, is similar between 80α and NM2, but differs in NM1 (Fig. 1). A corresponding relationship is found in the attachment (att) sites, which are recognized by the integrase.9 At the opposite end of the genome, the lysis genes (holin and lysin; NM1 proteins ABF73093 and ABF73094, respectively) are similar in 80α and NM1, but differ in NM2 (Fig. S1).
S. aureus strains TB25 and TB26 contain phages NM1 and NM2, respectively, lysogenized in the phage-cured S. aureus strain RN45029 (Table 3). RN10616 is an 80α lysogen.22 The lysogens were induced with mitomycin C, and the resulting lysates were purified by PEG precipitation and CsCl density gradient separation, as previously described.16 The purified NM1 and NM2 fractions were analyzed for the presence of phage particles by electron microscopy (EM). Both contained siphoviruses with 60 nm diameter icosahedral capsids and 185 nm tails (Fig. 3A,B), similar to those of phage 80α,16,17 and consistent with the previous report,29 except that we did not observe a difference in tail length between NM1 and NM2.
The crude lysates from the phage inductions above were filtered through a 0.22 µm filter to remove unlysed cells. The filtrates were used to infect S. aureus strain ST1, an RN4220 derivative that contains SaPI1 tst::tetM (Table 3). At 2–3 h post infection, unlysed cells were removed by centrifugation, and the resulting particles were purified as described above. EM revealed siphovirus particles similar to the phages, but having predominantly smaller (~45 nm) capsids (Fig. 3 C and D). This result shows that, like 80α, NM1 and NM2 both respond to the previously described SaP1-induced size determination.6
To test for the ability to transduce S. aureus, the 0.22 µm filtered lysates from the ST1 infections were mixed with S. aureus strain RN4220 and plated out on GL agar containing 5 µg/ml tetracycline. In all three cases (ST1 infected by 80α, NM1 and NM2), the lysates successfully conferred tetracycline resistance on RN4220, showing that the particles had been packaged with the SaPI1 tst::tetM genome (Table 4). PCR with primers specific to SaPI1 orf618 also confirmed that SaPI1 DNA was present in all three transductants (data not shown).
To test for mobilization of SaPIbov1, the filtered NM1 and NM2 phage lysates were used to infect ST137, which is an RN4220 derivative containing SaPIbov1 tst::tetM (Table 3) (G.E. Christie, unpublished data). As a positive control, the cells were infected with an 80α lysate in parallel. The resulting lysates were purified and analyzed by EM. Both large and small capsids were observed (Fig. 3E and F). Aliquots of 0.22 µm filtered lysates from the ST137 infections were used to infect RN4220. The NM1 and NM2 lysates were as efficient as 80α in conferring tetracycline resistance on RN4220 (Table 4). These results show that SaPIbov1 tst::tetM DNA had been successfully mobilized by both NM1 and NM2 and packaged into transducing particles, in spite of the lack of a recognizable Dut protein.
The only substantial sequence homology between 80α Dut and the corresponding proteins in NM1 and NM2 are two short, completely conserved motifs: an N-terminal MTNTL sequence and an internal GVSS sequence (Fig. 2C). These motifs are outside of the middle region that is divergent between 80α and 11 Dut, and that was previously shown to affect the rate of mobilization.10 In S. epidermidis phage PH15, which does not induce SaPIbov1,10 the MTNTL and GVSS motifs are not completely conserved, in spite of otherwise relatively high sequence conservation (40% identity; Figure 2C). Thus, the ability to bind Stl and mobilize SaPIbov1 might depend on these motifs. Alternatively, another factor encoded by NM1 and NM2 could be able to carry out the SaPIbov1 derepression.
Although only Dut has a known activity other than Stl derepression (as a dUTPase), Sri and other derepressor proteins are also assumed to serve some phage function, since the ability to mobilize a SaPI would seem to offer no benefit to the phage. Apparently, the SaPIs have evolved the ability to use these proteins to sense when an appropriate phage enters the lytic cycle and use this otherwise terminal event to their advantage.10
Double lysogens containing a NM1 or NM2 and SaPI1 or SaPIbov1 were made by introducing filtered lysates of SaPI1 tst::tetM or SaPIbov1 tst::tetM into TB25 and TB26, and selecting for tetracycline resistance, yielding strains AD1 (NM1, SaPI1), AD2 (NM2, SaPI1), AD3 (NM1, SaPIbov1) and AD4 (NM2, SaPI1bov1) (Table 3). A double lysogen of 80α and SaPIbov1 was made by introducing SaPIbov1 tst::tetM into the 80α lysogen RN10616,22 yielding strain AD5 (80α, SaPIbov1)(Table 3). RN10628, a double lysogen of 80α and SaPI1 tst::tetM was previously described.22 The use of double lysogens instead of infections circumvents the effects of variation in m.o.i. by ensuring a 1:1 ratio of phage to SaPI genomes. To eliminate the possibility of contamination from another helper phage, we used SaPI1 and SaPIbov1 lysates prepared with the same helper phage with which we made the double lysogens.
The resulting transductants were grown under tetracycline selection and induced with mitomycin C as previously described.16 Lysis for NM1 and 80α occurred after about 4 h. The NM2-containing double lysogens did not obviously lyse, but the supernatant was collected after 4 h and purified the same way as the other lysates. Unlysed cells were removed in the first centrifugation step. The difference in lysis for NM2 could be related to the differences in the lytic proteins, holin and lysin (Fig. 1).
To avoid the separation of different types of particles (procapsids, mature capsids, empty mature capsids) into different fractions that is inherent in the CsCl gradient purification, these particles were purified only by PEG precipitation and differential centrifugation, and imaged by EM (Fig. 4). The samples were not as clean as the CsCl gradient-purified particles, but included a representative distribution of procapsids and packaged, mature transducing particles of all sizes. A minimum of 300 particles were counted and measured for each double lysogen. The capsids were divided into four groups by size (large or small) and maturity (procapsids vs. mature capsids) and plotted as a fraction of the total number of capsids (Fig. 5). As observed previously16 many mature capsids are also empty due to abortive DNA packaging or loss of DNA during purification. These are easily distinguishable from procapsids and were grouped together with the mature capsids. A small number of aberrant shells that did not fit into any of the categories above were excluded from the analysis.
By this analysis, SaPI1 induced small capsid size equally efficiently in NM1, NM2 and 80α, with 90–95% small capsids formed, including procapsids and mature capsids (Fig. 5). Similarly, SaPIbov1 is equally efficient as SaPI1 in converting NM1 and NM2 to the small capsid phenotype: > 95% of the resulting capsids (procapsids and mature capsids) were, in both cases, small (Fig. 5). This was not surprising, in light of the high degree of similarity (99%) between the CP of 80α, NM1 and NM2 and the conservation of CpmA and CpmB, which are 94% and 96% identical, respectively, between SaPI1 and SaPIbov1.
When SaPIbov1 was mobilized by 80a, in contrast, only 63% of the resulting capsids were small (Figs. 4B and and5).5). It is unclear why this particular combination of SaPI and phage should be less efficient at size determination. It could be related to protein expression or the presence of other factors that modulate the effect of CpmA and CpmB. It is also possible that derepression of SaPIbov1 by 80α is less efficient, but the high transducing titers obtained with SaPIbov1 (Table 4) suggests that this was not the case.
In all cases, the majority of the of the capsids did not mature and remained as procapsids in the lysate. This is perhaps not surprising, as the cells may run out of energy to package DNA during the time between mitomycin C induction and lysis. The most striking example of this was NM1, for which 90% of the capsids observed were procapsids (Fig. 4A and 55).
Formation of small particles is one of the mechanisms by which SaPIs interfere with phage multiplication. Some SaPIs lack homologs of the cpmA and cpmB genes5 and are thus presumed not to change the size of their helpers, although this has not been confirmed experimentally. Nevertheless, the high conservation of these genes in many SaPIs suggests that the size determination does confer an evolutionary advantage on the SaPIs under some circumstances. SaPI mobilization depends on a delicate interplay between phage and SaPI-encoded proteins, and SaPIs have evolved multiple strategies for usurping the gene products encoded by the phage for their own benefit. All these mechanisms contribute to the overall fitness of the SaPI element and its subsequent success and establishment in the S. aureus population.
S. aureus strains used are listed in Table 3. S. aureus lysogens were grown in CY media at 32°C as previously described.33 For induction of prophages, mitomycin C was added to 5 µg/ml at OD600 = 0.8. Cells were grown until lysis occurred, as evidenced by a drop in OD600, typically after 3–4 h. The clarified lysates were precipitated with 10% (w/v) PEG 6,000 in 0.5 M NaCl and pelleted at 8,600 g for 20 min. The pellets were resuspended in phage buffer (50 mM TRIS-HCl pH 7.8, 100 mM NaCl, 1 mM MgSO4, 4 mM CaCl2) and centrifuged at 8,600 g for 20 min to remove insoluble material. The resulting supernatant was either centrifuged at 250,000 g for 30 min to pellet all capsid-related structures, or purified further on CsCl gradients, in which case 0.5 g CsCl was added per ml of supernatant, followed by centrifugation for 20 h at 70,000 rpm in a Beckman NVT90 rotor. Bands were collected and dialyzed against phage buffer.
For phage-induced SaPI mobilization, 50 ml cultures of the appropriate SaPI-containing strains (ST1 or ST137) were grown at 32°C in the presence of 5 µg/ml tetracycline. At OD600 = 0.5, the cells were infected at an approximate m.o.i. = 1 with phage lysates that had been passed through a 0.22 µm filter to remove any intact cells. The supernatant was collected after 2–3 h of growth, and the resulting transducing particles were purified by PEG precipitation and CsCl gradient centrifugation as described above.
For transduction assays, lysates from phage infections of equal volumes of ST1 or ST137 starting cultures were filtered through a 0.22 µm filter. Serial dilutions (100 µl volume) of the filtrates were mixed with an equal volume of RN4220 cells, incubated for 30 min at 32°C and spread on GL agar plates containing 5 µg/ml tetracycline. The plates were incubated at 32°C for 20 h and colonies were counted.
Double lysogens, containing both a SaPI and a prophage, were made similarly, by mixing the filtered lysates from infections of ST1 or ST137 with the appropriate recipient phage lysogen strain (TB25, TB26 or RN10616), incubating for 30 min at 32°C and spreading on GL agar plates containing 5 µg/ml tetracycline. After restreaking, single colonies were picked and grown in CY with 5 µg/ml tetracycline. For production of particles, the resulting double lysogens were grown and induced with mitomycin C as described for the phage lysogens above. Particles to be used for capsid size measurements were purified by PEG precipitation and differential centrifugation, but were not run on CsCl gradients.
The partially purified or CsCl gradient-purified material was diluted in 80α dialysis buffer (20 mM TRIS-HCl pH 7.8, 50 mM NaCl, 1 mM MgSO4, 1 mM CaCl2), applied to glow-discharged 400 mesh carbon-only grids (Electron Microscopy Sciences), washed with two drops of dialysis buffer, and negatively stained stained with 1% uranyl acetate. The grids were observed in an FEI Tecnai F20 electron microscope operated at 200 kV and imaged with a Gatan Ultrascan 4000 CCD camera at a typical magnification of 65,500×.
No potential conflicts of interest were disclosed.
We are grateful to Dr Taeok Bae at Indiana University Northwest for supplying the NM1 and NM2 lysogens used in this study and to Dr Gail E. Christie at Virginia Commonwealth University for supplying other strains and for helpful discussions. This work was supported by National Institutes of Health grant R01 AI083255.
Supplemental materials may be found here: www.landesbioscience.com/journals/bacteriophage/article/20632
Previously published online: www.landesbioscience.com/journals/bacteriophage/article/20632
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


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text: Corn salad was a salad from Earth which was prepared using corn. In 2371, Neelix learned to prepare familiar dishes for the USS Voyager crew, including corn salad for Chakotay and peanut butter and jelly sandwiches for Tom Paris. (VOY: "Faces") Retrieved from "http://memory-alpha.wikia.com/wiki/Corn_salad?oldid=1856540" Ad blocker interference detected! Wikia is a free-to-use site that makes money from advertising. We have a modified experience for viewers using ad blockers Wikia is not accessible if you've made further modifications. Remove the custom ad blocker rule(s) and the page will load as expected. Categories: Earth foods Add category Cancel Save Languages: Deutsch


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Lebanese, Syrian Military Chiefs Review Redeployment
High-ranking Lebanese and Syrian military officers met Friday in Beirut to review the latest redeployment of Syrian troops in Lebanon, reported the Daily Star newspaper on Saturday.
The meeting was seen as a step to allay fears among some about the motives behind the redeployment and its scope.
Lebanon's Army commander General Michel Suleiman received Major General Ibrahim Safi, commander of Syrian troops stationed in the country, who was accompanied by Major General Ghazi Kenaan, chief of Syrian intelligence in Lebanon.
A number of other senior officers were present.
Suleiman stressed the importance of cooperation and coordination between the two armies, especially with regard to the redeployment operation.
He paid tribute to "efforts and sacrifices" made by Syrian troops in achieving security and stability in the country and in backing the Lebanese Army in carrying out its "national duties."
The officers went on a tour of joint Syrian and Lebanese military positions in eastern and southern Lebanon, said the paper.
Syrian President Bashar Assad has confirmed that the surprise troop withdrawal from Beirut was coordinated by the military commands of the two countries, and that his forces' presence in Lebanon was temporary.
"What happened was a redeployment of the Syrian forces in Lebanon. This was the subject of technical considerations decided by the military in both Syria and Lebanon," Assad told the France 2 television station on Thursday.
"It is certainly connected to a decision of the political leaderships in both states. There is continuous coordination between the military leaderships in both countries (on this issue)," he said in the interview on the eve of his June 25-27 official visit to Paris.
Officials said that some of the troops which had left Beirut had joined other forces already deployed in the Bekaa Valley, but the majority had returned to Syria.
Assad declined to give a date Syria's full withdrawal – Albawaba.com
© 2001 Al Bawaba (www.albawaba.com)
Top Headlines
- Lebanese Forces chief ridicules Assad
- Senior Official: Syria Denies Meeting with Lebanon on Troop Redeployment
- Syria launches ''comprehensive redeployment'' from Lebanon
- Syrian President, Army Chief receive Lebanese Army Commander
- Hundreds of Syrian troops leave Lebanon as Powell consider redeployment as ''positive step''


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Ten hut, soldier!
It is imperative that you not only know who you're fighting, but also HOW to fight it. Our big bad in Puzzle Trooper? The forces of E.V.I.L! Our weapon(s) of mass destruction? Five color puzzle balls ready for carnage!
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After basketball practice, our coach took the team out to eat Friday. The guys on the team were talking about how hot the 29 year old waitress was. Little did they know, is that she's my girlfriend lol. She took our orders, Despite them trying to get her attention, she kept smiling at me. One of the guys asked for her number, once she (Mya) was done taking the orders, she kissed me and walked away. The entire team looked shocked and I didn't get what the big deal was. Lot's of guys date older gorgeous women. Why were they so shocked?
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I guess they were shocked that the waitress was your girlfriend perhaps? I mean it's not really a usual thing that a hot waitress kisses a guy out of the blue, is it00|00|0
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US stoner metal band formed in 1998 in San Francisco, California, by Matt Pike (guitar/vocals), Des Kensel (drums) and George Rice (bass). Pike had formerly worked with Sleep, the cult doom metal band that had disbanded the same year after their record company had refused to release their third album. High On Fire drew on the sound pioneered by Sleep, an intensely heavy reworking of the Black Sabbath / Celtic Frost blueprint, with Pikes aggressive guitar playing more to the fore than it had been in Sleep. The trios demo recordings attracted immediate interest from a number of independent metal labels, with Mans Ruin releasing The Art Of Self-Defense in 2000. Critics weary of the then fashionable rap metal and nu-metal sound greeted the album as a beacon of traditional heavy metal.
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Red ragtop by Tim Mcgraw heard on The Guilt Trip movie
Artist: Tim Mcgraw
Music By: Jason White
Overheard: 66 times
Music By: Jason White
Overheard: 66 times
TOP 20 Popular songs from films where this soundtrack is played
Cherry pie by Warrant
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Red ragtop lyricsI was twenty and she was eighteen,
We were just about as wild as we were green,
In the ways of the world.
Well she picked me up in that red rag top,
We were free of the folks
Reed full lyrics and hiding from the cops,
On a summer night, running all the red lights.
We parked way out in a clearing in a grove,
And the night was as hot as a coal burning stove.
We were cooking with gas
knew it had to last
In the back of that red rag top
She said please don't stop
Well the very first time her mother met me
Her green eyed girl had been a mother to be, for two weeks.
I was out of a job and she was in school,
And life was fast and the world was cruel,
We were young and wild, we decided not to have a child
So we did what we did and we tried to forget
And we swore up and down, there would be no regrets in the morning light,
But on the way home that night
On the back of that red rag top
She said please don't stop
Loving me
We took one more trip around the sun,
But it was all make believe in the end,
No I can't say where she is today,
I can't remember who I was back then.
Well you do what you do and you pay for your sins,
And there's no such thing as what might have been
That's a waste of time, drive you outta your mind.
I was stopped at a red light just yesterday,
Beside a young girl in a cabriolet and her eyes were green,
And I was in an old scene
I was back in that red rag top
On the day she stopped
Loving me (2x)


text:
With a stay at Shaftesbury Hyde Park International in London (Paddington), you'll be minutes from Whiteleys Shopping Centre and close to Royal Albert Hall. This 4-star hotel is close to Trafalgar Square and Big Ben.
Make yourself at home in one of the air-conditioned rooms featuring flat-screen televisions. Complimentary wired and wireless Internet access is available. Private bathrooms with shower/tub combinations feature complimentary toiletries and hair dryers. Conveniences include direct-dial phones, as well as safes and complimentary newspapers.
Take advantage of recreation opportunities such as a fitness facility, or other amenities including complimentary wireless Internet access and concierge services.
Enjoy a meal at a restaurant, or stay in and take advantage of the hotel's room service (during limited hours). Full breakfasts are available daily for a fee.
Featured amenities include complimentary high-speed (wired) Internet access, a business center, and currency exchange. Parking (subject to charges) is conveniently located nearby.


text:
[R.G. Mechanics] Lords Of The Fallen [2015, Action (Shooters, MMO FPS, TPS)] EN
Main Language: | Added:02-09-2016 | Author: Anonymous | Category: Games |
Torrent Score: 0
Full Title: [R.G. Mechanics] Lords Of The Fallen [2015, Action (Shooters, MMO FPS, TPS)] ENTitle: [R.G. Mechanics] Lords Of The Fallen
Genre: Action (Shooters, MMO FPS, TPS)
Platform: Windows
Multiplayer: No
Year: 2015
Type of publication:
Language of the game: EN
Description : Description :
In the era of the ancient god of evil rules the world and all of humanity lived under his heel. But fear, chilling the hearts of the people gave way to rage, and the morning came the Great Revolt, when the struggle for freedom. After a glorious victory over the overthrown god, people establish a new order ... in which there is no forgiveness of sin and salvation is not available to anyone.
Millennia have passed and the world is once again bound fear - because of the darkness came a legion rogarov - demons, driven by a diabolical thirst for innocent blood. Desperate humanity to call for help is very unusual defender - outcast society sinner imprisoned in the dungeon of sin ... a man named Harkin. Along with his mentor Castle they will travel to the heart of darkness ... to challenge the masters of the Fallen.
Immerse yourself in a dynamic RPG, is a sophisticated and interesting melee, in which the speed of the enemy's attack and determined set of weapons, armor and skills. And when a little force -
Embark on an epic adventure into the world of men and the world of demons
Meet the battlefield with powerful Lords, Army General rogarov
Explore a vast and dark fantasy world
Be careful - because every choice sudbonosen
Fight legendary weapons from a huge arsenal
Tags: No tags


text:
Black maxi skirt from T by Alexander Wang. Crafted from a matte jersey fabric, the long skirt comprises an elasticated high waistband and a close fit skirt with an elongated top layer forming a draped silhouette. Falls to an ankle length with a side slit cut to the thigh.
100% Viscose


text:
September 13, 2016
As Newport Beach city officials continue to grapple with regulating the short-term rentals popping up in residential neighborhoods, temporary lodging is also rising to the surface in the form of luxury vessels docked in Newport Harbor. As short-term rentals available through websites such as Airbnb, TurnKey and Vacation Rentals by Owner continue to swell in popularity, Newport has become one of several beach communities in Orange County grappling with how to regulate an industry that critics say has disruptive effects on communities….
Source: http://www.latimes.com/socal/daily-pilot/news/tn-dpt-me-short-term-rentals-20160913-story.html
September 13, 2016


text:
Thanks for checking out my shop! Check me out on instagram for more art and see how I do what I do and why. https://instagram.com/glitterbombart/
Lets spread glitterlove around the globe!
Thanks for checking out my shop! Check me out on instagram for more art and see how I do what I do and why. https://instagram.com/glitterbombart/
Lets spread glitterlove around the globe!
Shaland Sherratt on Jul 5, 2017
Love this hat! Tons of compliments!
Ashley Cobb on Dec 12, 2014
This painting was purchased as a gift, but I would love to keep it for myself! It's even more beautiful in person and the quality of the materials is great. A painting similar to this is definitely on my wishlist . . . Thank you Kassandra!
ccniemann0 on Aug 23, 2014
This is my fourth painting purchased from Kassandra and the sparkles and glitter are amazing! Every time I look at it, it just makes me super happy. Can't wait to buy more!!! Thanks Kass!
ccniemann0 on Aug 23, 2014
Love love LOVE my painting from Kassandra!! I have it on my living room wall and people always ask where I got it from. It's so amazingly colorful and happy!
GlitterBombArt by Kassandra
Well I am quite addicted to vibrant color and glitter. Bright bold intense saturated vibrating COLORS! And I also LOVE glitter. I love how each sparkle reflects light so my art comes alive. (See YouTube video below for a more detailed explanation.) For me, bright color and glitter equals magic and happiness. Making art has always been my safe happy place. I find dripping, pouring, and splashing color is great fun. I also find art is a great tool for releasing emotions, especially for children. Did I mention I have been a preschool art teacher at an amazing Montessori preschool for the past 11 years? GlitterBombArt was created with the intention to spread LOVE & JOY with glitter, color, and fun. Enjoy!
Love, Kassandra
See me on instagram here...
See a really cool YouTube video of me speaking about my art process here...
See me on Facebook here....
Check out my website here...
I love doing custom energy portraits. Check this link for more info...
Shop members
Kassandra Grossman Voigt
Owner, Maker, Designer, Curator
Shop policies
Accepted payment methods
- Accepts Etsy Gift Cards and Etsy Credits
Your purchase will be shipped 3-5 days from when your payment clears. Please feel free to ask me if you need it faster. I can see what I can do. All paintings and larger pieces will be shipped safely and securely with tracking number. Glitter notes come without tracking. Just ask if you want it. It will be a few bucks extra because of packaging.
Refunds and Exchanges
Please note, I have a super fluffy dog and 2 cats, I like to paint over old canvases, I paint on the floor of my studio, and I am very physical with my art painting process. If you are allergic to cats or dogs, well, beware.
***Color is VERY important to me and I do my very best to capture the true color in my photos. The color may be slightly off from what you see, but I guarantee it will be amazing in person. I am happy to send you MORE PICS, just let me know.***
Additional policies and FAQs
I always love custom orders and Energy Portraits. If you like a design but want it in different colors or you have other ideas please let me know.
Thanks much!
I retain my copyright to the art I make. All images displayed are property of Kassandra Grossman Voigt. The sale of original artwork does not include the sale of copyright. All rights reserved.


text:
- abject
- abject ab"ject ([a^]b"j[e^]kt), a. [L. abjectus, p. p. of
abjicere to throw away; ab + jacere to throw. See {Jet} a
shooting forth.]
1. Cast down; low-lying. [Obs.]
[1913 Webster]
From the safe shore their floating carcasses And broken chariot wheels; so thick bestrown Abject and lost lay these, covering the flood. --Milton. [1913 Webster]
2. Degraded; servile; groveling; despicable; as, abject posture, fortune, thoughts. ``Base and abject flatterers.'' --Addison. ``An abject liar.'' --Macaulay. [1913 Webster]
And banish hence these abject, lowly dreams. --Shak. [1913 Webster]
3. Sunk to a low condition; down in spirit or hope; miserable; -- of persons. [1913 Webster]
4. Humiliating; degrading; wretched; -- of situations; as, abject poverty. [PJC]
Syn: Mean; groveling; cringing; mean-spirited; slavish; ignoble; worthless; vile; beggarly; contemptible; degraded. [1913 Webster]
The Collaborative International Dictionary of English. 2000.


text:
Actor Srihari who is well known
as the real star of film industry has expired in Mumbai Leelavathi hospital.
Srihari who was born on 15-aug-1964
at Balanagar expired at the age 0f 49 due to cancer. Srihari started his career
as a stunt master in the industry; Srihari who is from a small background has
mingled with every one and had ginned a good stature in the film industry.
He later established him as a
villan, comedian and then moved on to become a hero with the film police, he
has acted more than 100 movie in his career. He was married to disco Shanthi
and has two daughters, Srihari moved onto Mumbai for the shooting of the upcoming
Rambo Raj Kumar.
He was feeling a bit uneasy
suddenly and has been taken to the hospital and finally he breathed his last
this afternoon, film industry is in a shock and with the loss of Srihari celebrities
of t-town showed a great gratitude for his death.


text:
A labor market is a system where the demand for all the components of an economy is fulfilled. It means
Search & Explore : Management Dictionary
Browse the definition and meaning of more terms similar to Labor Markets. The Management Dictionary covers over 7000 business concepts from 6 categories.
Related Business Content
Top Companies Lists 2017


text:
Last Updated Jun 24, 2011 4:47 PM EDT
The Kia ads in question (click to enlarge) were made by Brazilian agency Moma. One depicts a sexual situation between a male teacher and an underage student; the other shows two children in the Sleeping Beauty myth along side an an adult-oriented reinterpretation. They're intended to highlight Kia's hot-and-cold dual air conditioning zones for driver and passenger.
The Kia campaign won a Silver Lion at the Cannes ad festival in France, the most prestigious award show in the advertising business. But a look through the shortlist of winners shows that boorishness is a recurring theme.
This ad for Reporters Without Borders, which apparently shows President Obama groping Secretary of State Hillary Clinton, also shortlisted, was one of a series in which the censorship of a blurred image appeared to make an innocent situation seem prurient:
A shortlisted ad for Kitadol PerÃodo Menstrual, a period pain medicine in Chile, awards medals to the men who have to deal with women during that time of the month. Kitadol has previously depicted its female customers as masked wrestlers, boxers and martial arts fighters. The creative team at ad agency Prolam Y&R, Santiago, is all male.
And candy marketer Perfetti Van Melle apologized to BNET for approving a shortlisted campaign for Mentos in India that depicted its consumers committing suicide, even though suicides among indebted farmers in that country are a major issue. In an email, vp marketing Wouter Dorhout Mees confirmed that Mentos had commissioned the ad from Ogilvy & Mather Mumbai, and said:
This campaign was specifically targeted at urban youth in India who are exposed to and enjoy this kind of humour. We have not received a single complaint during or after the campaign.Of course, the Cannes Lions are awarded for creativity, not effectiveness. This is what's wrong with the ad business: What agency people value (crazy, edgy work) is not what clients need (stuff that sells). There is some of evidence that really awful campaigns work because they break through a highly cluttered media environment. But the fact that the agency world appears to be deliberately applying its best creative minds to the production of the most offensive ads they can make is depressing.
This campaign has already finished its run and will not be released again in the future in India or any other country.
... we apologize to you and any other person who has been offended by the ads.
There is hope. The Grand Prix winner at Cannes is this wonderful Samsonite ad from JWT Shanghai, which rewards careful viewing (click to enlarge):


text: home > medical podcasts by doctors audio podcast Medical Podcasts by Doctors MedicineNet broadcasts medical podcasts in MP3 audio format that you can easily download to your iPod or MP3 player. You can also listen to the medical podcast segments through your computer. To learn more about our medical audio library of sound files, visit: Audio Newsletters and Medical Podcasts New to Podcasting? A podcast is an audio file (MP3 format) published on the Internet. You can subscribe to a podcast audio feed (audio RSS) to automatically download podcasts when they are published. The technology uses RSS but instead of just supplying text, podcasts include audio. To subscribe to MedicineNet's medical podcasts, download and install one of the following software products: iTunes (for Mac + PC) iPodder (for Windows 2000/XP) iPodderX (for Mac) Copy the following MedicineNet RSS XML link into the software http://www.medicinenet.com/audio/audionewsletter.xml OR you can also use your RSS feed reader. RSS Feeds on MedicineNet MedicineNet also has medical RSS feeds available on many medical topics. These medical RSS feeds allow you to be notified when content relating to a specific medical topic is updated on MedicineNet. To learn more about MedicineNet's medical RSS feeds, visit: http://www.medicinenet.com/rss/article.htm From Healthy Resources Personalized Tips for Managing MigraineDo You Take Good Care of Your Eyes?Tips for a Clean Home & Healthy Cat Featured Centers 13 Best Quit-Smoking Tips EverWhat Stress Does to Your MouthHealthy Home: To Buy or Not to Buy Organic? Health Solutions From Our Sponsors Frequent Constipation? Greater Food Accessibility Exclusives What Does Psoriasis Look Like? How to Prevent Muscle Cramps Blood Clot? Know the Signs and Symptoms Allergy Triggers: Do You Know Yours?


text:
Forex Trading
Welcome to ForexWorker.net, the home of forex trading. We provide forex education & learning tools for free.
Find useful broker comparisons. Read about the recommended brokers through our site and you will receive the best reviews available for new clients.
Currency trading has gained worldwide popularity and to be profitable you need fundamental skills and a bulletproof strategy. ForexWorker offers all the resources and tools you need, whether you are new to online forex trading or an experienced trader.
Forex Brokers - The Best & The Worst
Some forex brokers are better than others. Here's an overview of the main foreign exchange services on the internet today.
What is Forex Trading?
The investor's goal in Forex trading is to generate earnings of movements in foreign currency. More than 95% of all Forex trading performed by speculative reasons (ie to generate earnings of movements in exchange rates).
What is Forex?
Forex stands for Foreign Exchange. In the currency market as a trader can achieve extraordinary returns and earn lots of money.
Currency trading online
Forex trading online is exciting and educational. Buy and sell currency, and earn money!
Forex Millionaires: There Is No Secret
Foreign exchange (Forex) can indeed make you rich. The question is: can you handle the risk?
How to Make Money
How to make money in a way that allows you to benefit from the money you earn? Here is the recipe for making a lot of money.
How to get rich in forex trading
Here are my top tips on how to be rich in foreign exchange trading. Want to fly high in a private jet, live life without financial worries and be able to afford everything you want to buy?
The Idiot's Guide To Forex Trading
Forex trading is for speculators, first and foremost an activity that is about making money. Exciting is too.
The Forex Market: History and Future
Today, the forex market a continuing active market where currencies are traded Nations, usually through a broker. Foreign currencies are bought and sold at the same time through local and global markets.
Forex Market Theory and Practice: How the Market Works
Your success in forex trading is greatly determined by your understanding of the forex market. We will take a brief look at the factors that affect the U.
Practical Forex Trading
Trading currencies online is easy. Learn how to spot opportunities in the forex market.
Technical Analysis In Forex
Technical analysis is a method of predicting price movements and future market trends by studying what has happened in the past using charts. Technical analysts are concerned about what actually happened in the market, rather than what should have happened, and taking into account price of instruments and handelsvoulmet and create charts from this data as a primary tool.
Fundamental Analysis In Forex
Fundamental analysis is a method for predicting future movements in the price of a financially instrument based on economic, political, environmental and other relevant factors. In practice, many participants in the market technical analysis with fundamental analysis to determine their trading strategy.
Best Forex Trading Advice And Tips
I am often asked how one should start out in forex trading. I can see how beginners find this a difficult task, but in reality forex trading is pretty straightforward and easy.


text:
ANALYSIS: 'Most OEMs able to meet 120g CO2/km by 2012' - analyst
Most vehicle manufacturers, including premium manufacturers, will be able to meet an average limit of 120g CO2 emissions per kilometre by 2012 through hybridisation, according to Frost & Sullivan senior research analyst Vijayendra R Rao. But BMW may struggle.
Get full access to all content, just $1 for 30 days
A Message From The Editor
just-auto gives its paid members access to the very best automotive market coverage.
And now there's just-auto plus, our premium membership that gives you exclusive component forecast data, company profiles and extended news coverage - just for premium members.
Today I can offer you 30 days access for $1 - and that includes just-auto plus.
Dave Leggett, editor of just-auto
* plus VAT if applicable
Only on


text:
Posted by anonymous
As with any life changing situation an individual faces in there time on this earth I was facing one of them in the form of a possible Dwi and Refusal charge this past June in the lovely (village) of Kodiak. As I was standing on the street in front of Kodiak's finest I contacted a friend whom Fred had represented previously, he afforded me Fred's cell#. Mind you it was approx 11:00pm yet Fred called me back nearly minutes after I left him a message. Immediately following the discussion with him I did what he suggested.
I'll cut to the chase. As with anyone facing these life changing circumstances I was assuming the worst. Fred did not sugar coat any facet of the situation and layed out the potential legal representation and the dollar figures for those services. The end result was a mistermeaner charge of recklessness endangerment, no points,no license ramifications, no SR-22, or a lot of the consequences of making a bad decisions. Unbelievable results considering the evidence against me. I would recommend Fred's firm to anyone facing one of these life-changing circumstances as I have to all my close friends. Thank you Fred for a job well done.
Posted by Stephanie
I was scared, stressed out and unknowlegable about a potential DUI lingering before me. Mr. Slone got right to work, defending me from every angle. He put me at ease and made sure I had clear understanding throughout the whole process. The prices were fare and the service is unparalleled. I would recommend Fred Slone to anybody who has received a DUI.
Posted by anonymous
Fred Slone is the choice for a DUI attorney in Anchorage or the Mat Su Valley. This was the advice given to me by a group of lawyer friends of mine. As a commercial airline pilot I was very concerned. They were correct. I could not be more pleased of the service that I received. Mr Slone and his staff worked tirelessly and continuously impressed me with the knowledge that he has gained in his thirty plus years of experience. Completely due to Mr Slone my DUI case was ultimately dismissed.
Posted by Shane
Fred Slone was an absolute pleasure to work with. I had no idea what I was facing and anxious about the possible outcome from the court system. To make matters more interesting I was an out of state client. From the very beginning Fred and his staff kept me informed of the process and patiently worked with me to explain the status of my case. Ultimately, It was under his counsel that my case was dismissed. I would recommend Fred Slone to anyone that was seeking representation in a DUI , DWI, or OUI case. The knowledge and service provided was excellent.
Posted by Jeff
I was referred to Attorney Fred Slone by a coworker. He and 2 others had successfully been defended from dui charges. I was arrested for dui on a Saturday night. Fred returned my Sunday call within a very short time. He and his staff immediately began paperwork for a DMV hearing. This postponed my CDL forfeiture, which would have immediately cost me my job.
I had very difficult circumstances stacked against me. I had been cooperative with the arresting trooper. Despite this, Fred was able to determine my "due process" had been violated. Fred successfully defended me in the DMV hearing, resulting in NO loss of CDL!
I was able to witness both Fred (and Landon) at work in the courtroom. They were very impressive in action, and it was obvious I made the correct choice by seeking their representation. Ultimately, Fred was able to get my breath test dismissed, and eventually the state dropped my entire case! No charges!
I have never needed representation before this. Fred, Landon, Dawn, and Cynthia did an excellent job helping me through this crisis. They answered all my questions promptly, and were courteous and understanding. All correspondence (emails, recordings, etc.) Arrived timely, and instructions were clear. Any additional paperwork requests I had to stay in compliance with my employer, were handled without hesitation. Fred's fee contract kept me from guessing when I was getting a bill, and how much it was going to be.
I know not everyone is perfect. Good people make bad decisions. If you or someone you know is in the same boat I was, you CAN NOT afford to wait. You CAN NOT afford to go it without Attorney Fred Slone! I am 100% confident Fred will give you your best opportunity for success, just like he did for me.
Posted by anonymous
I was referred by a friend to Fred Slone after a DUI charge. After I called his office, Mr. Slone met with me immediately and agreed to take my case. He explained in plain language my situation and the options that were available. He mapped out a course of action and worked very hard on my behalf. What especially impressed me was the willingness of Mr. Slone to take my many calls throughout the process. It was a very stressful situation and he was always available to answer questions and offer advice. The charges were eventually reduced due to the excellent work of Mr. Slone. I would highly recommend Mr. Slone to anyone seeking legal representation.
Posted by Sam
I was extremely pleased with Fred Sloan and the job that he performed with my case. From the beginning, Fred was helpful with explaining my options and letting me know how the process would work. He never once tried to push me one direction or the other on whether to bring my case to trial or not and left the decision in my hands. His firm handled the administrative work that was necessary for the court, which made it much easier on me.
Once I decided to bring the case to trial, Fred made sure to get all of the evidence for the case and was properly prepared for the trial once it began. His recommendations on certain aspects of the case, such as which evidence to include and his knowledge of the law to disqualify other evidence proved to be key in the case.
At the trial, Fred was extremely knowledgable and made sure to include my input in important decisions such as jury selection, after asking very informative questions during the selection process. Once evidence was presented Fred did an outstanding job on the cross examination of the prosecutors witnesses, which was another key aspect of the trial.
My overall experience with Fred Sloan and his firm was great and I would highly recommend them, especially for cases that are related to a DUI offense.
Posted by Nate
Mr Slone took the time to get all the information from my case and review all documents and video. His dedication to his work and the facts helped my case against the charge against me. His meticulous cross examination at the hearing proved how well he took the time reviewing my case from counting steps on the sobriety test to analyzing the video over and over, while looking for discrepancies in the officers written report and testimony. His hard work and experience got my case dismissed and my life back. Mr Slone is an amazing lawyer, he answered all my questions in a timely manner no matter big or small. I would recommend him to anyone needing help like I did.
Posted by anonymous
He didn't have very good personal skills. If it wasn't for his assistant lawyer Erin I would've driven myself insane. Erin was wonderful.


text:
These guides are designed for new users to SwiftKey or those looking to gain a better understanding of features.
We all know that typing can be frustrating at times - dealing with typos, long words, and the inevitable autocorrect fails. We've put together these handy guides to help you get SwiftKey set up and working seamlessly, so your keyboard is one less troublesome thing in your life.
This first guide to 'Setting Up SwiftKey' will take you through the following:
1 - Customizing SwiftKey
One of our top tips to get SwiftKey working for you is to really get to know your way around SwiftKey Settings - i.e. the command centre.
You can access these by opening the SwiftKey app directly from your device.
Within Settings you can really fine tune SwiftKey: set up things like your languages/layouts, key click sounds, your text correction preferences and more. You can even browse and download themes to beautify your keyboard.
OK - now that you know where to find everything, let's move on to setting up your languages!
2 - Languages
SwiftKey supports 106 languages on iOS, so, even if you speak more than one, there's a good chance we support yours! The iOS app also lets you type in up to two languages at once, this means less time spent switching and more time typing to the ones you love.
Downloading/Enabling languages
First things first: where to download and enable your languages?
You'll find this in the 'Languages' section in SwiftKey Settings (accessed by opening the app from your device):
- You'll see a long list of available languages - just tap one to download.
- Downloaded languages will be automatically enabled, and you can enable up to two languages at once.
Check out this article for a more detailed explanation.
Setting language layout
It may be that you wish to type in German, but with a QWERTY keyboard layout, or in English with a QWERTZ layout. So, how to change your language layout?
This can also be done from the 'Languages' section in SwiftKey Settings. Once you have downloaded a language pack, simply press 'switch layout' to see a list of available layouts and choose the one you want.
If you'd like to learn more about using SwiftKey with more than one language, please see this article.
3 - Personalizing and backing up your words
Turbo charge your SwiftKey experience right from the beginning with a SwiftKey Account.
SwiftKey Account
The SwiftKey Account is a free opt-in service that enhances your SwiftKey Keyboard by leveraging the power of the cloud. As part of this, you can:
- Instantly tailor your predictions to you, by letting SwiftKey learn from the way you type on a range of social networks (including Facebook and Twitter).
- Safely store your learned language data and sync it across all your devices (never lose your learned language data again!).
All you need to perform this magic is to:
- Create a SwiftKey Account (accessed by opening the app from your device and tapping 'Account').
- Tap 'Personalization' and choose which channels you'd like SwiftKey to learn from, like your Facebook or Twitter accounts (you can come back at any time and do this again).
- Ensure 'Backup & Sync' is enabled.
Privacy and Data Security
It's important for you to know that we take privacy and data security extremely seriously. The SwiftKey Account is an opt-in, secure, encrypted service that gives you full control over your data. Our robust Privacy Policy explains and protects your rights and privacy.
For further information about the SwiftKey Account, Personalization and Backup & Sync, please see here.
OK - keep going, you're almost there!
4 - Customizing your keyboard
SwiftKey offers many options when it comes to customizing your typing experience.
Text correction
One of the coolest things about SwiftKey is that it not only corrects your typos (and therefore saves you from multiple embarrassments), but it also predicts your *next* word (i.e. reads your mind!).
Now, you may be someone who loves mashing your fingers on the keyboard and having it be translated into intelligible words. Or you may instead be a very careful typist who wants full control. Do not fear - SwiftKey allows you to choose whether or not you want autocorrect turned on.
This option can be found in the 'Settings' panel (accessed from the SwiftKey Settings by opening the app from your device).
Tip: in each case, you'll still always be able to enter predictions directly from the prediction bar.
SwiftKey Flow
If you would like to type by seamlessly gliding your finger across the keyboard, then SwiftKey Flow is something you'll want to check out!
You can learn more about Flow later on in the guide (or check out this article if you just can't wait) but for now, you can give it a spin from the 'Settings' panel (accessed from SwiftKey Settings by opening the app from your device).
Key Click Sounds
Whether you love or hate the idea of hearing a sound every time you tap a key, you can enable or disable key clicks under 'Settings' in the SwiftKey Settings (accessed by opening the app from your device).
Please note that if keyboard clicks are turned off in Apple settings > Sounds, this will not affect the settings selected in SwiftKey. However, muting 'Ringer and Alerts' in Apple settings > Sounds, will also mute SwiftKey's key click.
For more detailed information, please see this article.
Haptic Feedback
We've added Haptic Feedback to SwiftKey. Small vibrations can be felt when opening the emoji panel, long-pressing the emoji/globe key, and activating the 'emoji bomb'.
Support for Haptic Feedback is limited to iPhone 7 and above. It is enabled by default, so you don't need to do anything.
If you want to learn more move on to our 'Using the Keyboard' tutorial.


text:
Hi guys!
I'm 17 and will be finishing school probably next year.
For a long time now, I'm planning to travel to London, New York and Seoul. I've been in Spain, Italy, Portugal and Greece so far but only for few days. Since I have a lot of time after school I want to travel all around the world probably with some friends and for the first time without parents.
So I collected some questions and it would be nice if you guys would answer them.
1. Are those cities / countries worth travelling?
2. What have your experience been with long-distance flights? Which Airline would you recommend and which not?
3. Although I've been flying multiple times now, I've never had a long-distance flight + I dislike flying overall, can you recommend me anything which will help me?
4. How long do we need to discover everything in the city without any time pressure?
Thanks guys, if you didnt understand one question just ask, english isnt my first language


text:
Hexagonal keychains match perfectly into a honeycomb-shaped wall organizer in this elegant home accent that'll support make certain you in no way drop your keys yet again. 'Honey, I'm Home' was designed in collaboration with Malorie Pangilinan for Fab's 'First Things First' competitors and showcase for NYCxDesign 2014.
"The concept behind the task is the iconic phrase, "Honey, I'm Property," of the 50′s that drew photos of the American Dream and currently being capable to come home soon after a extended day to your beloved husband, wife, son, daughter, or even cat, dog, or fish."