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Gene expression anti-profiles as a basis for accurate universal cancer signatures
Transcriptome analysis
Early screening for cancer is arguably one of the greatest public health advances over the last fifty years. However, many cancer screening tests are invasive (digital rectal exams), expensive (mammograms, imaging) or both (colonoscopies). This has spurred growing interest in developing genomic signatures that can be used for cancer diagnosis and prognosis. However, progress has been slowed by heterogeneity in cancer profiles and the lack of effective computational prediction tools for this type of data.
We developed
We have introduced
Early detection through mass screening remains one of the most effective approaches for reducing health care costs
Peripheral blood-based genomic signatures are a promising avenue for developing non-invasive cancer biomarkers
We complement our novel statistical approach with new biological insights related to cancer. For the colon cancer anti-profiles we incorporate the finding that consistent decreases in methylation are observed along large (5kb – 10Mb) genomic blocks
Gene expression variability and stochasticity have been studied previously in the context of normal populations
Results and discussion
Gene expression anti-profiles
We developed the
To illustrate our method we developed an expression anti-profile that distinguishes colon cancer from normal colon in tissue biopsies. We used two independent colon cancer studies, performed by different groups
Figure 1
The colon cancer anti-profile signature
The colon cancer anti-profile signature. (A) Normalized gene expression for 15 hyper-variable genes in cancer from two independent colon cancer datasets
To determine the relationship between gene expression hyper-variability and CpG DNA methylation hyper-variability, we examined a publicly available DNA methylation dataset comparing colon cancer with matched normal colon tissue on the Illumina HumanMethylation 27k BeadChip array (see Methods). We found that there is significant overlap between genes with hyper-variable expression in colon cancer and promoter region CpG hyper-variable methylation (Fisher's exact test OR=2.41, P=0.005, see Methods). We then repeated the experiment on the two colon cancer expression datasets using CpG hyper-variable methylation to select anti-profile genes and observed worse prediction performance (AUC=.84 and AUC=.97). Enrichment of hyper-variable CpG DNA methylation in blocks of hypo-methylation for this dataset has been previously reported
Colon cancer biomarker in peripheral blood
We combined the two colon-cancer tissue datasets described above and derived one
Additional file 1
Supplementary Material. This file contains supplementary Figures and Tables.
Click here for file
Figure 2
The colon cancer peripheral blood anti-profile
The colon cancer peripheral blood anti-profile. (A) Plot of the
Consistent hyper-variability across cancer types
We collected and manually curated a set of 6,172 cancer and normal microarray samples in biopsies (n=4,950 and n=1,222 respectively) from 59 tumor types and 102 normal tissue types across 176 different studies in the Gene Expression Omnibus (GEO,
Using these data we developed an anti-profile to predict cancer status regardless of tumor or tissue type. First, we confirmed that across-sample variability was a general characteristic of cancer (Additional file
Figure 3
Genes with consistent hyper-variability across cancer types
Genes with consistent hyper-variability across cancer types. (A) The 100 genes that most consistently show hyper variability across cancer types. We first define a normal range of expression using normal samples across all tissue types expecting that normal samples from a few tissue types will deviate from this normal range due to the tissue specificity of some genes. Each cell in the matrix indicates the percentage of samples of each type in which expression is outside the normal range. We observed that for the majority of genes, the percentage of samples in each normal tissue type outside normal range is close to either 0% (most tissues) or 100% (the small number of tissues for which the gene is specific). We also observed that in cancer, percentages are consistently away from 0% or 100%, indicating high variability. (B) Principal components for normal samples in adrenal cortex, colon, endometrium, kidney, skin, stomach and vulva. Circles illustrate profiles of normal expression for each tissue type. (C) Principal components for cancer samples. Increased variability is present in cancer but not manifested as multiple tightly defined sub-groups for each cancer type. Instead, we observe lack of regulation in cancer around tightly regulated regions of normal expression in each tissue type. The anti-profile method is based on this observation: stochastic departure from tightly regulated normal expression in these genes is characteristic in cancer and can be used in predictive settings.
Consistent hyper-variability across cancer is not due to cellular heterogeneity
Our results suggest that the universally consistent gene expression hyper-variability we report here cannot be fully ascribed to cellular heterogeneity in cancer samples. For a gene to show hyper-variability in cancer due to cellular heterogeneity, it must also be a marker for a number of distinct cell types in a heterogeneous cellular mixture found in a tumor. However, we found that a large number (45%) of universally hyper-variable genes in cancer are not consistently expressed in any of the normal tissues in our dataset (we say a gene is consistently expressed for a tissue if it is expressed in at least 95% of the normal samples for that tissue, see Methods section). This implies that, for almost half of the universally hyper-variable genes in cancer, hyper-variability cannot be the result of a heterogeneous mixture of markers for different cellular subtypes since these genes are usually silenced in normal tissues. Also, while hyper-variable genes are enriched in the set of tissue-specific genes, we found that the majority of tissue-specific genes are not consistently hyper-variable (64%). The vast majority of tissue-specific genes show hyper-variability in a small number of cancer types (Additional file
We also investigated the relationship between cancer-specific hyper-variability and tissue-specificity in the seven tissues for which we have sufficient samples of both normal and cancer. We found that the vast majority (95-99%) of hyper-variable genes in each of these cancers are not tissue-specific for the corresponding normal tissue (Additional file
Considering this finding, we investigated the relationship between cellular-specificity and the colon cancer peripheral blood result reported above. We determined genes that are specific to strictly one of two types of lymphocytes for which we had five or more samples in our dataset (CD4+ and CD31+ T-cells) and found that 12% of the genes used in the peripheral blood colon cancer anti-profile fall under this category. Furthermore, lymphocyte-specific genes are enriched in the set of genes with hyper-variable expression in colon cancer inside colon cancer hypo-methylation blocks (Fisher's exact test OR 3.0, P=1.2e-11). This suggests that we cannot rule out that varying lymphocyte composition in the peripheral blood samples of colon cancer patients may drive the prediction performance of the peripheral blood anti-profile.
Universal cancer anti-profile
While in the colon cancer anti-profile we restricted genes to be in the colon-cancer hypo-methylated blocks here we used our newly found biological insight: we restricted the anti-profile to tissue-specific genes defined as those genes that are expressed in at least 95% of samples for at most three tissues using the gene expression barcode method
Figure 4
A stochastic universal cancer classifier
A stochastic universal cancer classifier. (A) ROC curves for a 10-fold cross-validation experiment classifying
We used pathological tumor stage or grade annotation available for a subset of the samples used in the leave-one-tissue-out cross-validation experiment to determine if heterogeneity across samples in pathological tumor stage or grade may explain the increased gene expression variability observed in anti-profile genes used for prediction. For each of the leave-one-tissue-out experiments reported in Figure
We have introduced and developed gene expression anti-profiles for cancer biomarker discovery. Anti-profiles explicitly model increased gene expression variability in cancer to define robust and reproducible gene expression signatures capable of accurately distinguishing tumor samples from healthy controls. We have developed an
We note that Mammaprint
In this case we can use the anti-profile score, that is, the number of genes in the anti-profile where expression deviates from a normal range of expression obtained from normal breast tissue samples, to determine prognosis. Since this score is based on stable expression in normal tissues, it may be more robust than calculating correlation to a mean signature for tumors with good prognosis that would show high variability. This will require that more samples of both normal breast tissue and tumor are available on platforms for which robust, single-chip normalization methods exist.
In addition to developing a peripheral blood signature for colon cancer, we have confirmed the existence of hyper-variable genes across 59 distinct cancer types. We also provide evidence of the close relationship between hyper-variability across cancer types and tissue-specific gene expression. Consistent with these observations on tissue-specificity, gene ontology category enrichment analysis found that categories involving development, organ morphogenesis and differentiation are enriched with hyper-variable genes and the remaining gene categories enriched with hyper-variable genes involved cellular interaction with extracellular matrix, e.g., adhesion, localization and collagen catabolic processing or in cell locomotion and cellular component movement. These results argue strongly against the observed hyper-variability being a consequence of sample heterogeneity in the cancer samples.
Incorporating this general result on tissue-specificity and hyper-variability we developed anti-profiles able to classify tissue samples across multiple tissue and cancer types, even when a specific cancer/tissue type is not included in the original training set. Our cross-validation results suggest that consistent hyper-variability of a small set of tissue-specific genes is a stable mark of cancer across tissue types. Our results also suggest the potential for developing peripheral blood signatures for cancer diagnostics on the basis of
In the course of achieving these results we have used recently developed statistical preprocessing methods to remove potential artifacts in a way that is applicable to single clinical samples
Gene expression Affymetrix microarray data preprocessing
We downloaded CEL files for 6,172 Affymetrix HGU133plus2 microarrays from 176 studies in the Gene Expression Omnibus (GEO,
Colon cancer anti-profile
We used the HGU133plus2 probeset annotation from Ensembl (version 15, gene dataset version: GRCh37.p5) to map probesets to genes and obtain each gene's transcription start site. In the colon cancer anti-profile, we only consider probesets for genes with transcription start sites inside blocks of DNA methylation change (
Normal regions of expression are defined for each probeset as median expression +/− 5 median absolute deviations of expression in the normal samples. We found that our results are quite insensitive to the choice of median absolute deviation multiplier (Additional file
Colon cancer illumina HumanMethylation 27k array
We downloaded a publicly available dataset of methylation levels of 22 matched colon normal/tumor samples assayed using Illumina's HumanMethylation 27k array (GEO accession number GSE17648). Methylation measurements were used with no further preprocessing. Differences in methylation variability were determined using an F-test and significance determined at 1% false discovery rate. For each probeset in our expression data we found the CpG inside it's promoter region (defined as 1000bp upstream and 250bp downstream) nearest to the transcription start site. We determined significant expression hyper-variability using an F-test at 1% false discovery rate to determine overlap between expression hyper-variability and DNA methylation hyper-variability.
Colon cancer peripheral blood data
We obtained peripheral blood Affymetrix HGU133plus2 samples from colon cancer patients and healthy controls (
Colon cancer peripheral blood anti-profile signature
We defined the anti-profile from colon tissue by combining samples from the two colon cancer biopsy datasets used in the
Additional file 2
Table S3. Colon cancer anti-profile. Contains Affymetrix probeset ids and normal expression median and median absolute deviation.
Click here for file
To assess the sensitivity to signature size of the accuracy of the peripheral blood signature, we tested signatures of increasing size with genes included in order of decreasing hyper-variability across colon tumor samples (Additional file
Universal hyper-variable genes in cancer
To determine probesets that exhibit hypervariable expression in cancer we compute a variance ratio statistic across multiple tissues. We restrict this computation to tissues and cancer types with more than 10 samples in our dataset (list given in Figure
To define the universal normal range of expression we use a similar method: we compute median expression for each gene g on each tissue t separately (mgt) along with median absolute deviation (madgt)
Additional file 3
Table S4. Universal cancer anti-profile. Contains Affymetrix probeset ids and normal expression median and median absolute deviation.
Click here for file
Defining tissue-specific genes
To define tissue-specific genes, we tabulated the number of samples in which a gene is expressed (defined as gene expression barcode
Gene ontology category enrichment analysis
Gene ontology (GO) enrichment analysis was done using a hyper-geometric test for association between hyper-variable genes (defined as ug>1) and GO terms. We used the implementation in the Bioconductor
Cross-validation experiments
We performed two types of cross-validation experiments to quantify the accuracy of universal cancer anti-profiles. The first was ten-fold cross validation, data was randomly split into 10 equal-sized subsets, retaining the proportion of normal and cancer samples from the full dataset in each subset. Each of the 10 subsets (or folds) was used sequentially as a test set, scored using an anti-profile trained on the remaining 90% of the data (this includes all steps: 1) filtering to include only tissue-specific probesets, 2) computing the universal variance ratio ug
The other type of cross-validation experiment was carried out on the 7 tissues for which we had at least 10 samples each of normal tissue and tumor. For each tissue type, we performed a leave-one-tissue-out experiment by using all samples (normal and corresponding tumor type) as test set and scored them using an anti-profile trained on the remaining data. This ensures that
To classify a new sample we count the number of anti-profile genes for which their expression fell outside their normal range (Figure
Competing interests
The authors report no competing interests.
Author's contributions
HCB, JTL and RAI conceived, designed and performed experiments, analyzed data and drafted the manuscript; VP performed experiments and analyzed data; MM contributed reagents. All authors read and approved the final manuscript.
This work was partially funded by the National Institutes of Health R01 grant GM083084.
A cost-effectiveness analysis of colorectal screening of hereditary nonpolyposis colorectal carcinoma gene carriers
Breast cancer screening and cost-effectiveness; policy alternatives, quality of life considerations and the possible impact of uncertain factors
Cost-effectiveness of cervical-cancer screening in five developing countries
Cost-effectiveness of pancreatic cancer screening in familial pancreatic cancer kindreds
Reduction in mortality from breast cancer after mass screening with mammography. Randomised trial from the Breast Cancer Screening Working Group of the Swedish National Board of Health and Welfare
Breast cancer screening with mammography: overview of Swedish randomised trials
Screening sigmoidoscopy and colorectal cancer mortality
Mortality results from a randomized prostate-cancer screening trial
Reducing mortality from colorectal cancer by screening for fecal occult blood
Colorectal cancer screening: scientific review
Barriers to colorectal cancer screening: a comparison of reports from primary care physicians and average-risk adults
Factors associated with repeat adherence to breast cancer screening
Progress in cancer screening practices in the United States: results from the 2000 National Health Interview Survey
A prospective, controlled assessment of factors influencing acceptance of screening colonoscopy
Diagnostic clues for early pancreatic cancer
Screening for lung cancer: ACCP evidence-based clinical practice guidelines (2nd edition)
Identification biomarkers for cervical cancer in peripheral blood lymphocytes by oligonucleotide microarrays
Gene expression profiling of peripheral blood cells for early detection of breast cancer
Novel blood-based, five-gene biomarker set for the detection of colorectal cancer
Blood-based gene expression signatures in non-small cell lung cancer
Novel blood biomarkers of human urinary bladder cancer
Evolution in health and medicine Sackler colloquium: Stochastic epigenetic variation as a driving force of development, evolutionary adaptation, and disease
Increased methylation variation in epigenetic domains across cancer types
The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores
Genome-wide analysis of cancer/testis gene expression
Gene-expression variation within and among human populations
Population genomics of human gene expression
Genomic Analysis of QTLs and Genes Altering Natural Variation in Stochastic Noise
Gene expression variability within and between human populations and implications toward disease susceptibility
Variance of gene expression identifies altered network constraints in neurological disease
COPA–cancer outlier profile analysis
Outlier sums for differential gene expression analysis
Exploration, normalization, and summaries of high density oligonucleotide array probe level data
Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection
Converting a breast cancer microarray signature into a high-throughput diagnostic test
Frozen robust multiarray analysis (fRMA)
Assessing affymetrix GeneChip microarray quality
Evaluation of microarray preprocessing algorithms based on concordance with RT-PCR in clinical samples
Reversal of gene expression changes in the colorectal normal-adenoma pathway by NS398 selective COX2 inhibitor
Transcriptome profile of human colorectal adenomas
Gene Expression Omnibus: NCBI gene expression and hybridization array data repository
Using GOstats to test gene lists for GO term association
Linear models and empirical bayes methods for assessing differential expression in microarray experiments
The Gene Expression Barcode: leveraging public data repositories to begin cataloging the human and murine transcriptomes
Gene expression profiling predicts clinical outcome of breast cancer
A gene-expression signature as a predictor of survival in breast cancer
Why most gene expression signatures of tumors have not been useful in the clinic
An introduction to ROC analysis
Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach
pROC: an open-source package for R and S+ to analyze and compare ROC curves
Diagnostic mRNA expression patterns of inflamed, benign, and malignant colorectal biopsy specimen and their correlation with peripheral blood results
Statistical significance for genomewide studies


text: Home > Lifestyle > How to boast a beautiful smile > Bad breath Bad breath All sections in Lifestyle » Diet and nutrition » Fitness » Man » Sex » Parenting » Woman » Contraception » Environmental Health » Health and Your Money » Healthy Home » Healthy Workplace » Mental Health » Pet Health » Stop Smoking » Street Drugs » Sun » Teen » Travel Health » Ageing well » Natural Health » Health tech » All lifestyle sections advertisement From our sponsors Johannesburg conference to tackle digital transformation in healthcare Coital incontinence: the 'oops' women are too afraid to talk about Symptoms differ from person to person, identifying what triggers your IBS WIN a R2000 voucher. Great skin is just a click away! Live healthier Myths busted! » Breastfeeding may reduce pain from C-section Breastfeeding and work - how to make it work 9 breastfeeding myths busted Breastfeeding will help me lose my baby weight, right? Wrong! We bust nine myths about breastfeeding. Eat right. » How watching porn can cause erectile dysfunction 7 scientific ways to cure erectile dysfunction 7 foods that could relieve erectile dysfunction If you experience erectile dysfunction from time to time, you may be able to manage the problem without any medical help.

subset: commoncrawl


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Insulin: how it works
What is insulin?
Insulin is a hormone produced by the pancreas, a large gland that is located in the abdomen, behind your stomach.
Sugar regulation
Insulin is produced by special cells called pancreatic islets (or islets of Langerhans), which exist as small, isolated clumps of cells within the pancreas. The islets of Langerhans also produce glucagon, another hormone which affects blood glucose levels. Both insulin and glucagon are secreted directly into your bloodstream, and work together to regulate the sugar (glucose) levels in your body.
Glucagon is produced by the alpha cells of the pancreatic islets. It is released when your blood sugar levels are low (for example, if you have been fasting or exercising) stimulating the release of glucose from your body stores. As a result, stored glycogen in the liver is broken down to glucose and enters the bloodstream.
Insulin, on the other hand, is produced by the beta cells of the pancreatic islets. It is released when you have just eaten a meal and the level of glucose in your bloodstream is high. Insulin works by stimulating the cells within your body to take up the glucose in your blood, either for immediate energy or for storing as glycogen in your liver and muscle cells.
Insulin and diabetes
If your pancreas does not produce enough insulin, or if your body's cells fail to respond to the insulin being produced (insulin resistance), then your blood will contain too much glucose (hyperglycaemia). This type of metabolic disorder is known as diabetes mellitus. It is often characterised by excessive thirst or hunger, frequent urination, recurrent infections (such as vaginal thrush or boils) and blurred vision. Other symptoms include slow healing of wounds and cuts, feeling tired or weak, mood swings, headaches, dizziness, leg cramps, and unexplained weight loss (for type 1 diabetes) or weight gain (for type 2 diabetes).
If your body cannot use glucose as its energy source, it will start to break down fat. This releases by-products called ketones into the bloodstream which cause the blood to become acidic (a condition called ketoacidosis). If left untreated, this can lead to diabetic coma and even death.
In type 1 diabetes, the pancreas produces little or no insulin. In type 2 diabetes, the body does not respond to insulin: at first, the pancreas reacts by producing extra insulin (hyperinsulinaemia) but eventually it is unable to produce enough to meet the body's needs.
Achieving normal blood glucose levels
For these reasons it is important that people with diabetes stabilise their blood glucose levels. Ideally, blood glucose levels when fasting or before meals should be between 4 and 6 mmol/L, and blood sugar levels after eating should be between 6 and 8 mmol/L.
In people with type 2 diabetes and people with IGT (impaired glucose tolerance) there either isn't enough insulin or it does not function correctly which results in the levels of blood glucose being too high after a meal.
People with type 1 diabetes must have daily insulin injections — sometimes several times a day — to achieve their target blood glucose levels, while people with type 2 diabetes can usually control their condition with a healthy diet, sufficient exercise and/or the use of tablets known as oral hypoglycaemic medications. Eventually, however, many people with type 2 diabetes will require insulin injections.


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Steelers 24, Jets 19: My Top 10 Observer-ations
10. Some of us said all week that with the way the Jets celebrated wildly in New England, it was if they'd already won their Super Bowl. Proved astute right out of the gate as the Steelers set the tone with a 15-play, 66-yard touchdown drive to open the game. The Jets weren't emotionally primed.
9. I fondly -- yet barely -- remember a time when Marion Barber ran as hard as Rashard Mendenhall.
8. I can stomach the Terrible Towel in Cowboys Stadium without its creator and noted Cowboys antagonist Myron Cope not around to wave one.
7. Steelers win despite Ben Roethlisberger's quarterback rating of 35.5. Kind of how they won the Super Bowl over Seattle despite his 22.6 rating. You spell that explanation d-e-f-e-n-s-e.
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6. Not often does a team win an AFC Championship Game when its leading receiver has two catches for 38 yards, as tight end Heath Miller did for Pittsburgh.
5. One of the most underrated coaches of our time is Steelers' defensive coordinator Dick LeBeau.The names change, but the results produced by his defense remain consistently awesome. His contract expires after this season.
4. Two of the Steelers' biggest offensive plays came courtesy of unheralded Antonio Brown. Nursing a five-point lead, his 27-yard kickoff return gave Pittsburgh some breathing room and, of course, his diving 14-yard catch on third down sealed the deal.
3. A lot of the Cowboys' angle during Super Bowl XLV week will focus on Flozell Adams. But after watching how woeful kicker Shaun Suisham was a year ago -- the missed field goal in the playoff game at Minnesota helped set the tone -- who'da thunk he would be perched for a ring in 2011?
2. Felt bad for TCU-ex LaDanian Tomlinson. At the end of a 17-play, 88-yard drive in the fourth quarter, he couldn't squeeze past Casey Hampton and Brett Keisel on fourth-and-goal from the one. Game. Over.
1. My early gut says the Steelers will beat the Packers. My instincts also tell me that it's impossible to root for Roethlisberger. Remember, this is the guy who sat out the season's first four games for allegedly assaulting the Georgia college chick last March. Great player. Grimy person.
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Through Cubemate's guiding hand, I came across Watson Phillips Norman's Todd Norman's thoughts on planning and creativity. The gist of the article is that people like one double first from Oxford in physics and mathematics are bad planners because they're too smart, while humble and empathetic enthusiasts of pop culture and media who occupy a grey zone between creativity and ignorance are great planners because they are dumb. A good test of this hypothesis would involve a generation of systematic hiring of Ph.D.-carrying anthropologists (oddly omitted by Todd), archaeologists (understandably omitted by Todd), sociologists, psychologists and other social scientists for planning positions around the globe and an improved curriculum for these young professionals that would include applied training for product design, advertsing, PR and business strategy consultancy. Anecdotal cases of Nobel laureauts not being able to establish a rapport with an art director are hardly convincing. Alternatively, in order to fully exploit their teams of planners and not relegate them to self-deprecating advisors to all-powerful creatives, ad agencies should start working with the clients and the consumers at an earlier stage in the evolution of the relationship between the latter two. Product innovation, business strategy, field research into corporate and consumer culture are just the few trends that may help "planners" find their unique identity, an identity rooted not in imagination and not in rationality (both of these remain within the "known") but in the discovery of the "unknown" about human culture and behavior. That's how originally anthropology built its brand equity.
I attached a photo of a pen-as-toothbrush that I've picked up at a dentist office for a reason. This mutant is, in my opinion, a symbol of what a planner, a strategist, and an applied anthropologist is. He has to be able to inspire creatives and to remain detached from their creative process just to let it flow naturally and not be bummed by a "wrong course." But on the other end, he has to be able to author a brand/business strategy, a cultural analysis of a political campaign, a semiotic analysis of old ads, and a case study of an ad campaign that he's just let go of in order to recapture it later on a new level of execution. Finally he should be prepared to write a book of his own experiences doing all that. There's definitely a grain of truth in Todd's article, and a good balance of hardcore analytics with serendipity makes a great planner, but the wonderful workings of this mechanism still need to be explicated in order to salvage Todd's thoughts from falling into a grey zone between banality and failure.


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Greetings from the arctic, otherwise known as Illinois. Lol
SmokingMeatForums.com Top Picks
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Welcome aboard smokevirgin, great screen-name, lol. I think you'll find this forum pretty entertaining and educational. One thing's for sure, there is no end to the advice and instruction that you will receive - most of it good! Great to have ya.
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Glad you joined the group. The search bar at the top of any page is your best friend.
About anything you wanna know about smoking/grilling/curing/brining/cutting or slicing
and the list goes on has probably been posted. Remember to post a QVIEW of your smokes.
We are all smoke junkies here and we have to get our fix. If you have questions
Post it and you will probably get 10 replies with 11 different answers. That is
because their are so many different ways to make great Q...
Happy smoken.
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Welcome to the Smoking forum. You'll find great , friendly people here, all more than willing to answer any question you may have. Just ask and you'll get about 10 different answers—all right. LOL. Don't forget to post qviews.


text:
A claim is a tract of land, the right to mine of which is held under the Federal General Mining Law of 1872 and applicable local laws.
A product from a uranium production and milling facility, which is commonly referred to as uranium concentrate or U3O8.
A process whereby uranium concentrates are converted into forms suitable for use as fuel in commercial nuclear reactors.
Cut-off grade is determined by the following formula parameters: estimates over the relevant period of project costs, ore treatment costs, general and administrative costs, refining costs, royalty expenses, process and refining recovery rates and uranium prices.
Total acres under which we have mineral rights and can recover uranium.
A term derived from jurisdictional determinations in criminal law enforcement proceedings under 18 U.S.C. § 1151 and understood to encompass territory situated within Indian reservations, land owned by Indian allottees and land within a dependent Indian community.
A mineralized body which has been delineated by appropriately spaced drilling and/or underground sampling to support a sufficient tonnage and average grade. Such a deposit does not qualify as a reserve, until a comprehensive evaluation based upon unit cost, grade, recoveries, and other material factors conclude legal and economic feasibility.
Actual acres under lease which may differ from gross acres when fractional mineral interests are not leased.
Naturally occurring material from which a mineral or minerals of economic value can be extracted at a reasonable profit.
Operating enrichment plants in a manner that reduces plant operating costs but increases the amount of uranium required to produce a given quantity of enriched uranium.
Reserves for which quantity and grade and/or quality are computed from information similar to that used for proven (measured) reserves, but the sites for inspection, sampling and measurement are farther apart or are otherwise less adequately spaced. The degree of assurance, although lower than that for proven (measured) reserves, is high enough to assume continuity between points of observation.
Reserves for which (a) quantity is computed from dimensions revealed in outcrops, trenches, workings or drill holes; grade and/or quality are computed from the results of detailed sampling and (b) the sites for inspection, sampling and measurement are spaced so closely and the geologic character is so well defined that size, shape, depth and mineral content of reserves are well established.
Reclamation involves the returning of the surface area of the recovery and wellfield operating areas to a condition similar to pre-mining.
Reserves that are either proven or probable, are physically minable and can be profitably recovered under conditions specified at the time of the appraisal, based on a positive feasibility study. The calculation of usable reserves is adjusted for potential recovery and dilution.
That part of a mineral deposit which could be economically and legally extracted or produced at the time of the reserve determination.
Restoration involves returning an aquifer to a condition consistent with our pre-extraction use and removing evidences of surface disturbance. The restoration of a wellfield can be accomplished by flushing the ore zone with native ground water and/or using reverse osmosis to remove ions to provide clean water for reinjection to flush the ore zone.
A resource is a concentration of naturally occurring minerals in such a form that economic extraction is potentially feasible.
The configuration of sedimentary uranium ore bodies as they appear within the host sand. A term that depicts an elongate uranium ore mass that is 'C' shaped.
A term that refers to ceasing production or the absence of production.
A lease clause permitting the extension of a lease not held by production by payment of a per-acre royalty.
Fine particles of uranium concentrated and suspended in water.
The price at which uranium may be purchased for delivery within one year.
A bond, letter of credit, or financial guarantee posted by a party in favor of a beneficiary to ensure the performance of its or another party's obligations, e.g., reclamation bonds, workers' compensation bond, or guarantees of debt instruments.
Waste material from a mineral processing mill after the metals and minerals of a commercial nature have been extracted; or that portion of the ore which remains after the valuable minerals have been extracted.
U3O8 or triuranium octoxide.
Triuranium octoxide equivalent contained in uranium concentrates, referred to as uranium concentrate.
Barren rock or uranium in a rock formation that is too low in grade to be processed and milled at a profit.
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Luckily their new animated advert, featuring characters voiced by David Walliams, David Mitchell, Johnny Vegas, and Sir John Hurt, teaches us all what to do when a baby starts to choke. Taking on the character of objects which could potentially choke a baby - a small Princess toy, a pen lid, a jelly baby and a peanut - who have joined together because they've had enough and want to show how easy it is to save a choking baby's life.
The film starts with David Mitchell, as a chewed up pen lid, asking for the audience's attention. A jelly baby – Johnny Vegas – then explains that they're all fed up of babies choking on innocent objects like them. David Walliams' lofty Princess character demonstrates the correct technique – up to five back blows, followed by up to five chest thrusts – on the jelly baby, now turning blue, who quickly coughs out a peanut (Sir John Hurt), before returning to his normal shade.
You can see the video here:
Sue Killen, CEO of St John Ambulance, says:
"Knowing what to do in an emergency can be the difference between life and death, especially with something like choking. We all know how time pressed parents are so this film makes it as easy as possible to learn first aid – in less than 40 seconds we can all know a skill that could save a life. We hope people watch and share the video with their friends and family so more people have the confidence to act in an emergency."
Please share this post with your friends, family and social media today.
St John Ambulance is the nation's leading first aid charity, and believes that nobody should die because they needed first aid and didn't get it. Every year thousands of people die in situations where first aid could have given them a chance to live. St John Ambulance teaches people first aid so that they can be the difference between a life lost and a life saved. You can find lots more first aid advice on the St John Ambulance website, and also details of their first aid training courses.


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I been avoid to go because I can't put the contacts in my eyes. I want to go ask for app but I am scared of anyone judging me or calling me out. Sometimes i hate begin so young... people think its okay to walk all over you////
Most Helpful Guy
What about wearing glasses instead of contacts?22|00|0


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Exercise is not just a great way to get fit, the benefits of breaking into a sweat can help to improve the overall health of your mind, body and spirit.
While gasping for air in the middle of a heart-pumping workout, it can be difficult to imagine the often ignored benefits of exercising or joining a gym.
But consider these five often ignored ways that working out can work wonders in your life.
1. Make New Friends
Sparking up a conversation with fellow gym-goers not only passes the time during a strenuous workout, but also introduces you to new buddies who will encourage you through grueling routines. Before you know it, your social calendar will be packed with dates for friendly [health-conscious] lunches.
2. Improve Your Rhythm
Hip-hop, salsa or zumba? Pick your poison. There are tons of dance classes to choose from at your local gym and finding one to pique your interest will make you smoother on your feet.
3. Discover A New Passion
Why confine yourself to the typical routine of strength training and cardio? Spice things up with a game of racquetball, join an amateur basketball league, meet the challenge of the rock climbing wall or do something totally out-the-box and invigorating like Karate classes or surfing!
4. Increase Your Life's Focus
Allow your discipline and motivation in the gym to carry over into the everyday tasks that test your mental toughness. If you can push through five miles on the track, you can certainly endure a last-minute stack of tedious paperwork at the job.
5. Welcome A Better Wardrobe
Go ahead, enjoy your slim, new figure! Dropping those extra pounds and leading a healthier lifestyle are certainly positive benefits of working out, but fitting into your dream jeans? Icing on the cake.


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Concerns over Bulahdelah Hospital changes
Staff at Bulahdelah Hospital have joined local residents in fighting a proposed restructure that they say will lead to the facility being downgraded.
After unsuccessful attempts to attract a GP to the town, Hunter New England Health has flagged a refit of the Hospital with a shift from inpatient to outpatient and community based services.
Residents will meet next week to organise a rally in protest at the changes.
NSW Nurses Association Organiser Michael Whaites says staff are also upset that emergency services will cease.
"What it will mean is that people in Bulahdelah and surrounding areas will be relying on the ambulance service to take them to Taree and John Hunter Hospitals," he said.
"This is an hour in either direction to get to their local emergency department.
"Members at Bulahdelah hospital believe that an inpatient service need to be maintained at the site."
Mr Whaites says nurses who have been fighting alongside residents to save the Hospital, are opposing the plan.
"Our members have been fighting for a long time to maintain Bulahdelah Hospital as an inpatient hospital with 24 hour Emergency Department services for the local community and they want the government to commit to that," he said.
"We certainly look forward to open and transparent dialogue with Hunter New England Health but we are concerned that a position is being put that won't have much room to move on.
Topics: health, healthcare-facilities, bulahdelah-2423
First posted


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*After three weeks without chocolate oatmeal cookies, Hubs broke down and asked me to bake some. Of course, since he had also made me promise to stay away from the stores until grocery day (Saturday), my reponse was "sure. On Saturday." He was not impressed. Bwahahahah....I'm so mean.
*Jake was all pumped to go fishing yesterday. In the rain. I convinced him that standing in the rain was no fun, and so now he's going to be pressing to go today. Have I ever told you how much I hate fishing? We did go for a little walk the other day and found a lizard. Lizard!! Now that is weird, I've never seen a lizard in these parts. Apparently they do exist but I have no proof because it was too fast for my camera.
*I'm not nearly as obsessive over our vacation this year as I have been in previous years. Maybe it's because I've been to Moab. Or I have a good idea what to expect. This year I'm all laid back and...."Sure, the hotels are booked, the tours reserved, the route mapped. We just have to pack." I feel like I'm sitting here waiting to leave. :P All I need to do is get a hair cut, buy some travel medical insurance, and find a good bag.
*Our neighbors are home from their holiday. I suppose that means we can't water our back lawn on off days now. (oops! Did I just say that? )
*I actually fooled Hubs about the cookies~ I have all the stuff in the cupboard and plan to make them this afternoon. Who me? Mean? Never.
Wednesday, July 18, 2007
Posted by Karen Humphrey at 8:53 AM Labels: nonsensical rambling


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AFC Wimbledon boss Terry Brown wants his underfire defenders to adopt the hard-working ethic of the double-winning Arsenal defence of 1998.
Following a 6-2 mauling at Burton Albion on Tuesday night, the Dons' heaviest League Two defeat since winning promotion last year, Brown revealed he has no budget to spend on new players and must work with what he has.
Injuries to Curtis Osana and Callum McNaughton are not helping Brown as he struggles to put square pegs in round holes in his makeshift
But he believes hard work is the secret because it worked at Arsenal with Tony Adams leading Lee Dixon, Nigel Winterburn and Steve Bould.
"I have got to stiffen up the back four, but I have spent my budget and I need to get more out of the players I have got," Brown said.
"It has to be done on the training pitch and it is all about working hard. The formula behind some of the best defences in history are those that worked at it the most and Arsenal in the late nineties is a prime example of that. That's what we need to aim for.
"It doesn't help that I have not been able to play my preferred back four and because it is early in the season it is actually difficult to know what that is.
"I am playing a centre half at right back and we're getting hurt down the wings. I need to get Curtis [Osana] back from injury as soon as possible."
The Dons conceded four goals in 20 minutes at Burton to find themselves 4-0 down at the break and then 6-0 down within 70 minutes. Late goals from Byron Harrison and Pim Balkestein salvaged some pride for the travelling fans.
Brown said: "The only positive, and it is a very small positive, is that at 6-0 we kept on playing and got a couple of goals.
"We could have got even more, which in a way is more frustrating because we were not able to benefit from any of our attacking play. Defensively we weren't good enough.
"The fact we conceded four goals in half an hour tells it all, and Burton didn't have to do too much to get the goals. They weren't carving us open with football, we just weren't dealing with balls played in behind our defence."
Brown added: "But you cannot dress it up any other way really, it was bitterly disappointing. More than 400 fans made the long journey and no one wants to get a spanking."
The Dons travel to Bradford on Saturday and Brown told his men to tighten things up or face the consequences.
"Bradford have spent a penny or two, so that will be a difficult game. They are a big club with big ambitions, but we've really just got to go up there and concentrate on being more solid at the back and being harder to beat. We cannot go away and be as open as we were at Burton."
Luke Moore and Rashid Yussuf picked up knocks on Tuesday remain doubts for the trip to Yorkshire.


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Day 1: Arrive at the Torbay Court hotel, Paignton this afternoon where we stay for 3 nights.
Day 2: A trip to the beautiful town of Dartmouth. Explore the variety of unique shops all located around the harbourside and quaint streets and enjoy the delightful riverside traditional style Park with bandstand.
This afternoon we spend some time back in Paignton.
Day 3: Day trip to Plymouth. We visit the Waterfront area known as the Barbican as well as the city centre.
Day 4: Making our way home after breakfast.
Price includes 3 nights D/B/B plus travel and trips out as shown. Single Supp £19
3 minutes walk to Seafront and 5 mins level walk to pretty shopping Centre & steam railway and within easy reach of Paignton zoo.
Hotel is adjacent to a very pleasant public garden.
56 guest rooms with ensuite bath or shower room. TV, Tea/Coffee tray, hairdryer.
Lift to all floors. 6 ground floor rooms.
Regular evening entertainment in lounge with Large Dance Floor and bar.
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2013 Leafs Trades/Proposals/Signings Version II
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Originally Posted by
same guy who is one of those "there's always next year" or "no worries we will get em next time" dudes....
buy they went a whole CBA without making the playoffs and their record is no better with these leaders then it was before they came.. Both are compliment pieces to an elite foundation, not elite leaders..
Stop saying fans are frustrated cause we are 5 games in... this goes back a long ways for some.. its a build up of on going losing...
I don't dispute that these are compliment pieces. Phaneuf is overpaid for what he brings, no question. It's not the frustration that is the biggest issue, it's the over reaction. Fans always want to make a trade, to fix things now somehow. Somehow people didn't see this type of play coming?
While I would agree that the amount of points is no better than the pre-Burke period, I do believe we have started to build a foundation of decent young players and prospects. Hopefully we can draft one more excellent piece this year, and pick up some critical UFA's. It has been apparent for several years that this team was setup for this upcoming UFA season.
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Well it might have been the end of Eve Walters, but her legacy had far reaching implications across shallow space. We explore that legacy in a series of snippets from faction press outlets.
(Missed the story? Then catup-up: 1, 2, 3, 4, 5)
"Terrorists neutralised in coup for Pleiades Police."
In another triumph for the Corporation's principles and methodologies, terrorist Eve Walters was apprehended by Corporate Police earlier this month.
Walters was part of a network of Imperium dissidents jealous of the advances and comfort bestowed upon Corporate employees and attempting to bring us down to their level.
Walters resisted arrest and her ship was damaged during the chase. She later succumbed to her injuries, but not before recording a video confession of her crimes. Eve Walters will serve as an example for any other criminals intent on damaging the Corporation.
"Public Announcements."
We like to think that those that share in Illegal Refreshments have a common bond, if not full friendship then at least a sense of comradery. In this vein we have a public announcement for those that may be affected:
1) Gregory Walters' ship was destroyed leaving dock in the Oberon system, apparently due to systems failure on board his freighter. In a twist of cruel fate, his daughter Eve Walters was also killed by pilot error this month. The family is survived by Gregory's son Jimmy who is carrying on the family business.
2) We have been notified that 'scoundrel of fortune' Jack Hamilton has been out of touch with his contacts for the last month. We know many of you disprove of his recent actions, but he is part of our large family, so if you see him please tell him to get in touch.
3) Kane Guptill has been working with the Shallom Clan attempting to recreate Shallom's last movements before his disappearance a decade ago. He believes he is on to something and will be making an announcement at the next Kill4 meeting.
"Pleiades Corporation: 'Killing Civilians OK'."
Readers of Incorporated Now will be familiar with the work of Eve Walters, a celebrated journalist from Mayflower, who has previously contracted to Incorporated Now (And stirred up the odd hornet's nest too).
We found her in-your-face attitude refreshing and our Corporation's management graciously saw the funny side in her antics.
But earlier this month we learnt of her untimely death in the Pleiades System. Rumours abound regarding how and where she died, but one thing this journal is sure of is that something stinks.
She didn't die by accident.
Eve was doing what Eve does best and the Pleiades Corporation killed her for it. We here at Incorporated Now believe it is our solemn duty to warn all our readers, here in Incorporated Space and beyond, to stay away from the Pleiades system as they clearly sanction the murder of Imperium citizens. You have been warned.
We will be sending a delegation to Mayflower to mourn our lost friend at her memorial. Employees are welcome to apply for dispensation to also attend the memorial.
The GUARDIAN
"Award Winning Reporter Tragically Killed"
It is with regret and sadness that we must report the death of one of our own. Eve Walters, a prize winning journalist for our respected media outlet, died in the Pleiades system last month.
Official police reports indicate pilot error by the commercial charter she was using, crashing into one of the many asteroids in the system after attempting to escape police custody.
Eve had been researching violation of the Eugenics Accords by the Pleiades Corporation who in turn claim Eve was engaging in acts of terrorism. Anyone who knows Eve knows this simply is not true and our lawyers are currently in contact with the PLC in regards to this slander.
Eve was a highly valued member of the team at The Guardian and will be sorely missed. There will be an open memorial service at York on Christian's World, Mayflower on April 26th.


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tag:blogger.com,1999:blog-3030368038490158017.post6949002262459206382..comments2017-08-19T17:33:02.605-04:00Comments on Dawg Business: It's Your Dog's Health!: Symptoms To Watch For In Your Dog: Excessive PantingJana Radehttps://firstname.lastname@example.com:blogger.com,1999:blog-3030368038490158017.post-52502765201357210602017-04-04T19:34:21.265-04:002017-04-04T19:34:21.265-04:00Yes, I agree that a check-up and some basic labs a...Yes, I agree that a check-up and some basic labs are a good idea in any case.Jana Radehttps://email@example.com:blogger.com,1999:blog-3030368038490158017.post-24714167858138213142017-04-04T12:47:22.618-04:002017-04-04T12:47:22.618-04:00Thank u I spoke with my vet today they said give m...Thank u I spoke with my vet today they said give my baby aka dog few days as it could be a diet problem causing the symptoms so have to try him on chicken necks chicken thighs n rice as he has had other dog dry food which I normally give him super coat but my mum's dogs don't eat the one they brought them so they gave it to me to try so it didn't go to waste so back to super coat n diet for few days to see how it goes he didn't have any yukky burps today so I'm praying it's just the diet but of no better before Friday then our vet wants to run test but have booked him in for a check up anyhow for Friday even if he is better thank u for ur reply means alot I worry so much about my dog like I do my own babies part of the family he is a amazing n beautiful My babyhttps://email@example.com:blogger.com,1999:blog-3030368038490158017.post-61467209552139491422017-04-04T12:32:10.614-04:002017-04-04T12:32:10.614-04:00Yes, I'd see a vet with this and not wait for ...Yes, I'd see a vet with this and not wait for things to get worse which they could. There could be a foreign body, obstruction, or something else equally serious going on there. Please do see a vet.Jana Radehttps://email@example.com:blogger.com,1999:blog-3030368038490158017.post-47532519017169285152017-04-03T11:35:10.750-04:002017-04-03T11:35:10.750-04:00Hi my dog is normally pretty healthy playful but t...Hi my dog is normally pretty healthy playful but the last three days now he is had a rotten egg smell when he burps and has spewed twice in the three days but has been dry reaching a few times I know dogs can get the flu but I'm worried should I take him to see a vet his still drinking and eating n playful but I'm just worried can anyone help with this Q plz ? My babyhttps://email@example.com:blogger.com,1999:blog-3030368038490158017.post-16449385943286052632017-02-06T11:17:35.227-05:002017-02-06T11:17:35.227-05:00Since she started behaving unusually, there is som...Since she started behaving unusually, there is something causing it. While the test for Cushing's is quite demanding, starting with urinalysis and basic blood panel can provide clues as to what to look for next.Jana Radehttps://firstname.lastname@example.com:blogger.com,1999:blog-3030368038490158017.post-30333656465912408242017-02-05T22:11:34.781-05:002017-02-05T22:11:34.781-05:00I have a Rotti she started panting slow then faste...I have a Rotti she started panting slow then faster drinking licking the covers fixed her so her head is flat and she has stopped panting, she is 9 1/2 and the panting is off and on more in the evening I asked my vet about checking for Cushing but she didn't think it was needed.Rotti momhttps://email@example.com:blogger.com,1999:blog-3030368038490158017.post-38800222091187211392016-11-05T10:06:33.190-04:002016-11-05T10:06:33.190-04:00Aging it itself doesn't come with any symptoms...Aging it itself doesn't come with any symptoms. Diseases and medical conditions that can crop up with age do. Walking gingerly could be indeed hips, or could be something internal. Abdominal pain can cause posture changes as well. Panting can be sign of pain or other problem. Most of these things can be well managed if addressed properly.

I'd start with full physical and labs to determine what exactly is happening and then see what options there are to fix or manage it.Jana Radehttps://firstname.lastname@example.com:blogger.com,1999:blog-3030368038490158017.post-60769248925575972882016-11-04T22:03:17.162-04:002016-11-04T22:03:17.162-04:00My dog will be 10 next month and she's been wa...My dog will be 10 next month and she's been walking pretty gingerly like her hips are sore. She has recently started panting, too. Is there anything to be done about that or is it just a sign of aging?Unknownhttps://email@example.com:blogger.com,1999:blog-3030368038490158017.post-50622935211169203502016-11-04T19:03:50.003-04:002016-11-04T19:03:50.003-04:00Just had an incident with my Pomeranian. Got home...Just had an incident with my Pomeranian. Got home, let the boys out to pee. When they came back in they get their treat. Well, the bigger dog started excessive panting with his tongue out farther than I've ever seen it. Took about 20 minutes to figure out that he had a bad case of stomach pain, due to gas from gobbling up his chicken strip as fast he could. Gave him Nutrical first... since I had No idea what was going on. Then grabbed him and started a general massage along his back. Then started a gental massage on his belly and such. He eventually burped, wanted more massage, and now seems to be getting himself back to normal. Dogs do wierd shit when they have pain of any type, just like us. Go for a simple explanation before running to a Vet ER.Monsterpomhttps://firstname.lastname@example.com:blogger.com,1999:blog-3030368038490158017.post-23181370054118087962016-10-19T09:43:19.541-04:002016-10-19T09:43:19.541-04:00She is showing serious signs of distress. I cannot...She is showing serious signs of distress. I cannot tell you what is going on but with these signs I'd be back at the vet. Particularly with a dog this young, you don't want to take chances.Jana Radehttps://email@example.com:blogger.com,1999:blog-3030368038490158017.post-64045079726835128362016-10-19T02:21:36.668-04:002016-10-19T02:21:36.668-04:00I have a 13 week old Great Dane. We got her with h...I have a 13 week old Great Dane. We got her with her first shots and deworming at 8 weeks. She's now had all her shots (except rabies) been dewormed 3 times. At her 12 week vet visit they gave me an antibiotic for her for puppy rash. She was fine with it for the first 4 days, then had vomiting and diarrhea so we stopped the antibiotic, the rash is gone, but this morning I took her out and she had roundworms in her poop. Picked up deformed at vet and gave it to her with a meal. But all evening she's been restless, won't lay down, is panting, whining. Is this a side effect of the worms or the mess or could something else be happening email@example.com:blogger.com,1999:blog-3030368038490158017.post-14432719536307120582016-09-12T11:12:28.358-04:002016-09-12T11:12:28.358-04:00What breed is Lilith? How old? While panting could...What breed is Lilith? How old? While panting could be due to anxiety from the change, loss of bark would not be. There are a number of things that could be going on but to find out which and to treat it you need to see a vet. Please do that. Physical exam and consultation does not cost that much.Jana Radehttps://firstname.lastname@example.com:blogger.com,1999:blog-3030368038490158017.post-52902209810093923852016-09-11T23:05:40.201-04:002016-09-11T23:05:40.201-04:00My Lilith is panting constantly!!! She also can ba...My Lilith is panting constantly!!! She also can barley bark!!! She lives with my parents now as i cant have her at my house (looking to move to have her with me) since then ive noticed that she has begun panting way more and recently she has lost her voice!!! Shes able to bark a low woof but thats it. I thought maybe she barked too much and maybe strained her vocal cords but this has been over a week now. I do know she has separation anxiety from me shes used to being by my side since she left her mother. But her beautiful bark is gone and she just keeps panting!!! Does anybody have an idea what is wrong with her? Im trying to raise the money to take her to the vet but as a single mother its hard i love her so much!!!!!!Candis Blancohttps://email@example.com:blogger.com,1999:blog-3030368038490158017.post-43595160930384974042016-08-18T08:43:42.060-04:002016-08-18T08:43:42.060-04:00Hon, the internet isn't a good place to come t...Hon, the internet isn't a good place to come to with emergencies nor I can even begin to guess what's wrong with your girl. You mean the "hernias" popped up out of the blue? I would strongly recommend you call around to see if any veterinarian or dog rescue would help you.Jana Radehttps://email@example.com:blogger.com,1999:blog-3030368038490158017.post-21479431014518285582016-08-17T21:31:04.368-04:002016-08-17T21:31:04.368-04:00Help I can't decide what is wrong with my baby...Help I can't decide what is wrong with my baby girl. She is a 13 year old Chihuahua Pug mix that is 20 pounds and I am so scared to lose her. She started panting like crazy just a few hours ago. Yes it's been hot but not hot enough to make her pant this hard. She also has small hernias all over her stomach and I am terrified. Is my best friend dying? Am I going to have to bury her or put her down for her own good? God the line between right and wrong is hard to define right now... please I really need some help please tell me what to do I can't afford to go to the vet to have her properly taken care of and I don't know how to diagnose anything I am only a massage therapy student. Please just tell me what to do I'm scared...Warrior Girlhttps://firstname.lastname@example.com:blogger.com,1999:blog-3030368038490158017.post-11602139745731105762016-08-17T21:27:07.401-04:002016-08-17T21:27:07.401-04:00Hello I honestly don't know which is wrong wit...Hello I honestly don't know which is wrong with my dog and I am very scared she is a 13 year old overweight Chihuahua she weighs 20 pounds and doesn't eat much anymore I am worried I'm going to lose my best friend because I cannot diagnose what is wrong with her and I cannot afford to take her to the vet I don't want to have to put her down and I don't want to have to lose her but I don't want her suffering in pain I am so scared I don't know what to do please helpWarrior Girlhttps://email@example.com:blogger.com,1999:blog-3030368038490158017.post-48318183630574629762016-08-14T21:15:45.515-04:002016-08-14T21:15:45.515-04:00This is very similar to my pup. I noticed that she...This is very similar to my pup. I noticed that she doesn't really yawn fully, like she tries, but it looks fake..She has been panting and breathing heavily for a few months now, most of the time. She gets winded with very little exercise and pants like crazy..but she is a lively 7 month old GR, and plays and eats like normal. I have taken her to the vet TWICE, two different vets, and both say she seems fine and is probably just not acclimating well to the Summer (Arizona). My house is always 77-79 degrees. I don't buy it, but THAT is what you get from the professionals, folks.Unknownhttps://firstname.lastname@example.com:blogger.com,1999:blog-3030368038490158017.post-25857827868466645272016-08-14T21:15:10.330-04:002016-08-14T21:15:10.330-04:00This is very similar to my pup. I noticed that she...This is very similar to my pup. I noticed that she doesn't really yawn fully, like she tries, but it looks fake..She has been panting and breathing heavily for a few months now, most of the time. She gets winded with very little exercise and pants like crazy..but she is a lively 7 month old GR, and plays and eats like normal. I have taken her to the vet TWICE, two different vets, and both say she seems fine and is probably just not acclimating well to the Summer (Arizona). My house is always 77-79 degrees. I don't buy it, but THAT is what you get from the professionals, folks.Unknownhttps://firstname.lastname@example.com:blogger.com,1999:blog-3030368038490158017.post-40369715477991561682016-08-13T12:35:03.531-04:002016-08-13T12:35:03.531-04:00There may be a number of different things going on...There may be a number of different things going on there. Sounds like at least two problems in one. Please do see a vet.Jana Radehttps://firstname.lastname@example.com:blogger.com,1999:blog-3030368038490158017.post-41020723560021938622016-08-13T12:14:46.257-04:002016-08-13T12:14:46.257-04:00Hi i have a 13 yr old lab she had hysterectamy2 yr...Hi i have a 13 yr old lab she had hysterectamy2 yrs ago she has many lumps an bumps on her she keeps having these turns where she doesnt know where or wat shes doing her eyes flick from side to side she is blind due to catarachs but continuously pants except when she goes to sleep she drinks excessively but still eats well ivecalso noticed bits that fall from her mouth are frothy Doodleshttps://firstname.lastname@example.com:blogger.com,1999:blog-3030368038490158017.post-40713056132488652502016-07-29T09:29:12.769-04:002016-07-29T09:29:12.769-04:00Tianna, there can be a number of different things ...Tianna, there can be a number of different things causing this. Most commonly it's an expression of pain of any sort or discomfort. This may or may not be related to the surgery (post-op infection maybe?) or the original reason the surgery was done, or it could be something unrelated all together.

It's good that you noticed and I would talk to the vet about it and have him seen to get to the bottom of it.
Jana Radehttps://email@example.com:blogger.com,1999:blog-3030368038490158017.post-90517318102106256982016-07-29T04:49:01.774-04:002016-07-29T04:49:01.774-04:00Have a question my English bulldog had bracacephal...Have a question my English bulldog had bracacephalic surgery about a month ago and the last couple nights he seems like he has a hard time relaxing and sleeping he is up and down breaths per min seem to be normal but U can tell somthing is bothering him what is causing this tianna caseyhttps://firstname.lastname@example.com:blogger.com,1999:blog-3030368038490158017.post-52709020213922731692016-06-06T09:15:55.236-04:002016-06-06T09:15:55.236-04:00I would be concerned as it's happening during ...I would be concerned as it's happening during the time of rest. I would do a vet check-up to make sure her heart is working properly and nothing else is wrong.Jana Radehttps://firstname.lastname@example.com:blogger.com,1999:blog-3030368038490158017.post-36507283526570298132016-06-05T22:36:31.630-04:002016-06-05T22:36:31.630-04:00My 3 year old female pug has been breathing heavil...My 3 year old female pug has been breathing heavily at night the past few nights. If I wake her up, she starts panting heavily for a bit and then falls back to sleep and the heavy breathing starts again. She doesn't pant during the day. Is this something I should be concerned about? She just got over being in firstname.lastname@example.com:blogger.com,1999:blog-3030368038490158017.post-29554146027762493042016-05-15T08:47:54.465-04:002016-05-15T08:47:54.465-04:00Hi Jessica, the dog needs to see a vet as soon as ...Hi Jessica, the dog needs to see a vet as soon as possible. The vet will find out why he's having a hard time getting up and such things can be managed with medication and physical therapy. There might be weight issue - is he thin, heavy or really heavy? Physical exam and blood work will tell about organ function and about what might be going on with the body. Lumps need to be examined and aspirated.Jana Radehttps://email@example.com


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Suffolk drug bust
Suffolk County released the photos of individuals arrested in a drug sting. The gallery represents the charge at the time of the photo. Newsday.com will not be updating the status of these cases. All are presumed innocent unless proven guilty.
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Am an unknown but i have something to surprise you (hope so).
Here i am to –
Express about myself and my thinking,
Share happenings and best moments, my ideas and the experience i have obtained throughout !
Let me show you what i have got,
See you around , See Ya !
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Two minutes' silence have been held to remember those who have fallen in battle.
Marked by the first stroke of Big Ben at 11am and the firing of a gun from Horse Guards Parade by The King's Troop Royal Horse Artillery the silence was followed by The Last Post, sounded by the Buglers of the Royal Marines.
The Queen laid the first wreath at the Cenotaph in Whitehall, London, followed by the Duke of Edinburgh, the Duke of Cambridge, the Duke of York, the Earl of Wessex, the Princess Royal, Prince Michael of Kent and Field Marshal Lord Guthrie of Craigiebank.
Wreaths were also laid by Prime Minister David Cameron, Liberal Democrat leader Nick Clegg, opposition leader Ed Miliband and Westminster Plaid Cymru group leader Elfyn Llwyd, as well as high commissioners from Commonwealth countries and leaders of the Armed Forces.
Thousands of veterans have also marched through Whitehall to pay their respects at the Cenotaph.
The Prince of Wales and Duchess of Cornwall, currently on their Diamond Jubilee Tour in New Zealand, had already paid their respects, laying a wreath of poppies at the Auckland War Memorial Museum.
There are a number of services taking place, including at the National Memorial Arboretum in Staffordshire, St Giles Cathedral in Edinburgh and Enniskillen in County Fermanagh.
For the first time, the two most senior members of the Irish government will attend Remembrance events in Northern Ireland.
Irish premier Enda Kenny was in Enniskillen, 25 years after the 'Poppy Day bombing' which killed 11 people and injured more than 60. Mr Kenny laid a laurel wreath at the war memorial, only yards from where the no-warning blast detonated a quarter of a century ago
And deputy leader Eamon Gilmore laid a wreath with Northern Ireland Secretary Theresa Villiers in Belfast.
In Lashkar Gah, Afghanistan, around 150 servicemen and women attended a service at 11am Afghan time, marking the two minute silence before a bugler sounded the reveille.
Other ceremonies have been held across Helmand at patrol bases and checkpoints by the 9,500 British forces serving there.
Thousands of people also respected the two minute silence on Twitter, abstaining from posting messages during the period of reflection. The idea was spread using the hashtag #2minutesilence.
On Saturday night, Rod Stewart performed for the Queen at the Royal British Legion's Festival of Remembrance in honour of Britain's war dead.
The show included the traditional two minute silence as poppy petals fell from the roof of the Royal Albert Hall, each representing a life lost in war.
Two minutes of silence begin at 11am every year on November 11 to commemorate the armistice signed between the Allies of World War I and Germany for a ceasefire on the Western Front, which took effect at the eleventh hour of the eleventh day of the eleventh month of 1918.


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Bodi ONathan Photographer
Kian Cross 1Model Male Bournemouth, England, United Kingdom
Mayhem # 2824036
About MeFrom Bournemouth, Went into the world of Dj'ing in 2005. (Well known for my work infront of the camera), Since 2008 i've been hosting and presenting events weekly, such as private birthday's and wedding's, live day/evening/night events and done lots of work on interviewing famous stars.
Have a broad portfolio of work encompassing music, films and travel and everything inbetween.
Have you worked with Kian Cross 1? Add Credits for Kian Cross 1! >>
Bodi ONathan Photographer
My O Photo Photographer
Ruby Walker Photographer
Anoop Wilson Photographer
Speed of Film Photographer
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Between 2000 and 2008, the Hong Kong Eating Disorders Association identified 1,170 cases of eating disorders from more than 2,300 inquiries on its hotline. Of those, more than half were cases of bulimia; about 30 per cent were anorexia and almost 10 per cent involved eating disorders not otherwise specified. More than half of the sufferers were aged between 16 and 25.
Unspecified eating disorders have been on the rise, accounting for 39 per cent of cases identified in 2008, with bulimia making up about 33 per cent and anorexia about 27 per cent.
Here are some signs shown by people who may be suffering from an eating disorder:
1 Marked or continuous weight loss
2 Absence of menstruation
3 Restrictive diet and rigid/unusual eating rituals
4 Frequent checking of body weight/size (intense fear of gaining weight)
5 Repeatedly seeking assurance about being thin
6 Refusing to eat (arguing with parents about food intake)
7 Social withdrawal (to avoid eating or disclosure of eating rituals/restrictions)
Philippa Yu, clinical psychologist and head of the association, says apart from cultural and family influences, friends can help teenagers overcome their eating disorders. Yu offers the following advice:
Set a good example to your friends and don't bring up the 'fat' topic
Make eating a social event with your friends
If your friend expresses fears about weight gain, shift the discussion to other, interesting topics
Be understanding towards a friend's eating problems
Appreciate your friend's efforts to overcome their illness
Persuade your friend to take part in normal social activities
Additional reporting by Mabel Sieh


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Arthur Vistain was the third husband of Marlene Vistain, previously Marlene Fisk.
Arthur married Marlene some time after her marriage to Martin, her second husband. He passed away shortly before Marlene moved into Saint Bénézet Retirement Care. Marlene kept his name because she thought it sounded like royalty.[1]
- Marlene Vistain - Widow
- Wilson Fisk - Stepson


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What is JotForm?
JotForm is a free online form builder which helps you create online forms without writing a single line of code. No sign-up required.
At JotForm, we want to make sure that you're getting the online form builder help that you need. Our friendly customer support team is available 24/7.
We believe that if one user has a question, there could be more users who may have the same question. This is why many of our support forum threads are public and available to be searched and viewed. If you'd like help immediately, feel free to search for a similar question, or submit your question or concern.
Can I add drop down fields along with text fields to a MatrixAsked by carnegies on December 11, 2016 at 10:52 AM
I am trying to add drop down fields with fixed choices along with text fields for random entry to a Matrix. Can I do this?Also, how do I change the widths of the columns in a Matrix?
The form I am working on is https://www.jotform.com//?formID=63415833177863#
Thank you!
JotForm Support
Hello carnegies,
Please note that you can only have one field type in matrix field. That means you can not have a textbox along with dropdown field. If you just want to add dropdown field in matrix field, it is possible to achieve. Please check the screenshot below:
If you want to use more than one field type in matrix field, I would suggest you to use "Configurable List" widget and see if that fits into your account.
I have moved your second question to a new thread and you will be answered here: https://www.jotform.com/answers/1008657
Thank you!


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31 Pillar Ln., Hot Springs Village, AR 71909
- $12,900
- 1+ Years on site
- Beds: n/a
- Baths: n/a
- Raw Land
BUILD YOUR DREAM HOME ON THIS EXCEPTIONAL ISABELLA GOLF COURSE NEIGHBORHOOD LOT. IT SITS UP HIGH AND OVERLOOKS THE ISABELLA GOLF COURSE AND POND ACROSS THE STREET. THIS LOT IS MINUTES FROM THE EAST GATE AND IS WITHIN DRIVING DISTANCE FROM FIVE GOLF COURSE BY GOLF CART! THERE ARE BEAUTIFUL HOMES IN THE AREA ON THIS PRIVATE LANE. CALL FOR MORE INFORMATION! Click here to learn more about this listing.
- Year Built: n/a
- 1+ Years on site
- Raw Land
- Beds: n/a
- Baths: n/a
Listing Details
- Lot Size
- Approximately 0.41 Acres
Local Info
| Median Household Income
| Median Years In Residence
| Median Homeowner Age
| Households with Children
| Percent of Homes Rented
Nearby Elementary Schools
- Fountain Lake Elementary School
- 4207 Park Ave
- Fountain Lake Middle School
- 4207 Park Ave
- New Beginning Christian Academy
- 132 Patience Ln
Nearby Middle Schools
- Fountain Lake Middle School
- 4207 Park Ave
- Lighthouse Christian School
- 1075 Fox Pass Cutoff
- Christian Ministries Academy
- 548 Brookhill Ranch Trl
Nearby High Schools
- Fountain Lake High School
- 4207 Park Ave
- New Beginning Christian Academy
- 132 Patience Ln
- Christian Ministries Academy
- 548 Brookhill Ranch Trl
These are the closest schools to your requested location. Proximity does not guarantee enrollment eligibility. Please consult your real estate agent or school district to confirm the schools you are zoned to attend.
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text: It was, to be sure, an example of serendipitous timing. With the Commerce Department reporting on Tuesday that June retail sales were up by 0.6%, more than 600 institutional investors descended upon the Oppenheimer Consumer, Gaming, Lodging & Leisure Conference in Boston to be convinced that the future of retail is -- well, let's just say to be convinced that there is a future. "Retailers and brands cannot be afraid of the word 'recession,'" Marshal Cohen, chief industry analyst at NDP Group said in his keynote address. "Consumers can deal with it if the retailer learns how to address their new mentality." Cohen predicted that consumers will open their wallets for innovative products and ideas -- but not those who are simply hoping to ride out the recession until the economy returns to "normal." "But the new normal will not be what we saw two years ago," Cohen said. "People will go back to shopping more like they did 10 years ago." And on that mixed note, several retailers and consumer goods-makers vied to prove that they were prepared to capture that new, withered consumer dollar. Tupperware ( TUP) CEO Rick Goings, for one, announced that his company has targeted to have at least 25% of sales come from new products launched within the last two years. He added that Tupperware has been attempting to shed its "June Cleaver" persona by shifting the focus from function to design and beauty. "The way we do this is by making Tupperware fashionable in new colors and styles and improving some of our older products," Goings said.


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Iberian Lynx
Lynx Pardinus
Bella Veloz and NINA MATTS
An Iberian Lynx, also known as the cat with eyeliner, is the most endangered big cat. Iberian Lynx's live in the semi-deciduous forests of Southern Spain. They eat European Rabbit, which makes up 90% percent of their diet. But the Lynx is not dying off because it's being hunted. Nothing hunts the Lynx. The Iberian Lynx is dying because the European Rabbit is dying of disease. With nothing to eat the Lynx starves. This makes the lynx CRITICALLY ENDANGERED. There are thought to be less than 50 adults left. Another reason they are dying off is they can only have 2-3 babies at a time and they have to be at least 1 year old.


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Small Group Training
- >>>>
Small group training, or semi-private training, is a great option if you want to work with a personal trainer at less cost than a one-to-one session. Join one of our pre-scheduled sessions or put together your own group of workout partners!
Contact us for a copy of the most recent Small Group Training Schedule.


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Bayern and Bremen moved closer towards securing first and third place, respectively as Schalke lost, and both Leverkusen and Dortmund could only earn draws.
Bayern Munich 3-1 Bochum
Borussia Dortmund 1-1 Wolfsburg
Eintracht Frankfurt 1-2 Hoffenheim
Koeln 2-2 Freiburg
Hamburg 4-0 Nuernberg
Hannover 6-1 Borussia M'gladbach
Schalke 0-2 Werder Bremen
Stuttgart 2-2 Mainz
Bayer Leverkusen 1-1 Hertha Berlin
Despite being all but mathematically relegated, Hertha put their best foot forward today, and nearly earned an improbable victory. Theofanis Gekas hit the bar early on before Raffael struck in the opener after 12 minutes. Leverkusen battled back and would not concede another opportunity before the break. The winter champions came close several times, but could not equalise before the half-time break.
Shortly before the hour mark, Manuel Friedrich headed in a corner, bringing Leverkusen back on level terms. The German defender came close to nodding in the winner late, but was denied by the crossbar. Hertha goalkeeper Jaroslav Drobny had to fend off a veritable hailstorm of shots, but but managed to avoid conceding a late goal, and the game ended in a draw.
Bayern Munich 3-1 Bochum
Click here to read full match report...
Borussia Dortmund 1-1 Wolfsburg
Still in the hunt for a third place finish, Dortmund dominated the first half, forcing Wolfsburg goalkeeper Diego Benaglio to make a heroic effort to deny an opener. The Ruhr side appeared to have earned their opener on 34 minutes, when Peter Pekarik conceded a penalty to Kevin Grosskreutz. Nuri Sahin stepped up to take the spot kick, but Benaglio again denied the hosts with an excellent save in the lower right corner of goal.
In the second half, Wolfsburg were much improved, and strikers Edin Dzeko and Grafite came out of the woodwork. In the 69th minute, Dzeko finished well from close range, giving the defending Bundesliga champions a deserved lead. Though initially stunned, Dortmund battled back and drew level as 19-year old substitute Marco Stiepermann scored in just his second Bundesliga appearance. Both teams had their chances in the late going, but neither could net a winner, and the match ended in a draw.
Eintracht Frankfurt 1-2 Hoffenheim
In a cagey first half only Pirmin Schwegler's brilliant effort from long range could separate Frankfurt and Hoffenheim. Given space to shoot, the central midfielder hammered in the opener for the hosts.
Play opened up more in the second half, which suited Hoffenheim. After Chinedu Obasi was unable to equalise, substitute Prince Tagoe pulled the visitors level with a fine finish on the break. Back on level terms, both teams looked to score a winner, and Tagoe proved to be the difference maker. The Ghanaian striker reached a long ball from goalkeeper Daniel Haas, and netted a late winner for the visitors.
Koeln 2-2 Freiburg
Still not quite assured a place in next year's Bundesliga campaign, Freiburg were dealt a shocking blow early on, when red-hot winger Zoran Tosic put Koeln ahead in the ninth minute. The hosts dominated possession, but were unable to put much pressure on the Freiburg defence. The team from Germany's southwestern corner were clinical with the ball, and equalised on 31 minutes as Mohamadou Idrissou finished from a corner kick.
With Koeln lacking a cutting edge in attack, Freiburg were the more dangerous side in the second half. Idrissou completed his brace on 57 minutes, and in doing so, all but confirmed Freiburg's final position above the league's bottom three. Sebastian Freis put Koeln on level terms in the 84th minute, but the visitors held on for a draw, putting them four points clear of the drop.
Hamburg 4-0 Nuernberg
Less than 48 hours after crashing out of the Europa League, Hamburg looked to finish their domestic campaign on a high note, and potentially overcome Stuttgart before the end of the campaign. Jonathan Pitroipa netted early for the hosts, and a quickfire brace from Mladen Petric ended the game as a contest within 25 minutes.
Nuernberg had a few chances in the second half, but were always on their heels, and conceded a fourth as substitute Ruud van Nistelrooy pounced on his opportunity and took his goal with typical class. Nuernberg had no answer, and will now need a win on matchday 34 to stand a chance of avoiding relegation.
Hannover 6-1 Borussia M'gladbach
An inspired Hannover team stormed out of the relegation zone today following an emphatic win over Moenchengladbach. First half goals from Karim Haggui, Sergio Pinto, Didier Ya Konan, and Mike Hanke put the hosts in full control, but with goal difference critical at this time in the season, Hannover pushed for more. Sofian Chahed added a fifth before Gladbach's Patrick Herrmann traded goals with Arnold Bruggink to cap a 6-1 result.
Schalke 0-2 Werder Bremen
In this week's most highly-anticipated clash, Bremen took a huge victory over Schalke. The hosts had their chances in the first half, but Jefferson Farfan and Kevin Kuranyi could not put away their opportunities, and the two teams entered the break on level terms.
Early in the second half, Mesut Ozil silenced the home crowd with a crucial opener, putting Bremen a step into the Champions League. Nine minutes later, the German international set up Hugo Almeida for Bremen's second, and Schalke could make no response. The result has all but finished off Schalke's title hopes, and left Bremen in control of their own destiny as they try to secure a third place finish.
Stuttgart 2-2 Mainz
Mainz, who have struggled on the road this year, were outplayed in the first half, but managed to limit their opponents' goalscoring opportunities. As a result, the visitors were able to secure a 0-0 scoreline at the half.
Early in the second period, defender Malik Fathi scored from a corner, causing Stuttgart to open up at the back. Andre Schuerrle doubled the visitors' advantage on 63 minutes with a fast break goal, leaving the Swabians with a mountain to climb. Stuttgart battled back, however, and Ciprian Marica netted a brace within two minutes to draw the score level. Stuttgart pressed forward over the final quarter hour, but failed to score the winner. As a result, they will need to draw with Hoffenheim next week in order to ensure a Europa League position next year.
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New Balance M530GBP Trainers in Blue / Grey. New Balance bring one of their most popular runners from the 90's in this contemporary colourway. Mesh panels are accented by leather / suede overlays whilst the entire shoe sits on an Encap midsole for comfort and durability. An XAR-1000 rubber outsole is added for enhanced grip.
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text:
What is JotForm?
JotForm is a free online form builder which helps you create online forms without writing a single line of code. No sign-up required.
At JotForm, we want to make sure that you're getting the online form builder help that you need. Our friendly customer support team is available 24/7.
We believe that if one user has a question, there could be more users who may have the same question. This is why many of our support forum threads are public and available to be searched and viewed. If you'd like help immediately, feel free to search for a similar question, or submit your question or concern.
How can I add a dollar sign in the input fields?Asked by RogerYelvington01 on February 21, 2017 at 03:00 PM
JotForm Support
Is this just for the form view or you want the sign to also appear in the email? You are using a number field, it's not possible to put an alpha character there. You have the dollar sign in the sub-label so I think that explains the value.
If you really want to have it, you need to change it by a textbox field and add it as a default value:


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pink street team
Apply to be on Texas Tech's pink street team
send resume & cover letter to firstname.lastname@example.com
deadline is Sunday 1/19 at noon
The Texas Tech PINK Street Team is comprised of a select group of girls that love the PINK brand just as much as we do! You will work directly with your PINK reps to promote PINK and PINK NATION on campus through events, flyers, social media and word-of-mouth! The Street Team will help plan, organize, set-up and tear down events as well as being responsible for recruiting students to go to our PINK events! This commitment and will last through the end of the Spring 2014 semester. There are no prior qualifications for this job we just ask that you are fully committed and that you include your major/classification in your resume. Any questions can be sent to firstname.lastname@example.com as well as your resume and cover letter :) We will select our team by Monday evening and there will be a mandatory meeting next Thursday at 6pm!
WRECK 'EM and LOVE PINK


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im dating a man online and I want to break up with him, he has a nude pic of me (which I deeply regret) and I'm afraid that he will black mail me with it or something? just really worried :(
Most Helpful Girl
Nude pic or not, guys can get back at you with any photo of you by posting it all over the web with your phone number underneath it, saying mean things about you. That's the risk anyone takes posting their pics online. The internet is not a safe haven, that's why I don't post my pics online. I had all kinds of things done to me, still recovering...11|00|0
oh I'm really sorry to hear that :S what a bunch of a**holes who would do such things, my Facebook account is the only place I have pics on, and I have security settings and no enemies lol, and I hope I don't make a new one after breaking up with him :(