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Blue Man Group - Klein Mandelbrot (HQ) MP3
Klein Mandelbrot, track 13 from "Audio" by Blue Man Group.
Blue Man Group Klein Mandelbrot video MP3
Music Copyright (C) Blue Man Group 2009 video clips belong to BBC and Denee ( aka bluemanhuggger) Enjoy!
Klein Mandelbrot MP3
Provided to YouTube by Universal Music Group Klein Mandelbrot · The Blue Man Group Audio ℗ 1999 Blue Man Group Records LLC under exclusive license to ...
Blue Man Group Klein Mandelbrot - Drum Break MP3
Just a short drum break from Blue Man Group's Klein Mandelbrot without the Guitar.
Klein Mandelbrot snare MP3
Connor plays a bit of Blue Man Group's "Klein Mandelbrot" on just the snare drum. He really wanted to use the bongos so he could have more variety in the ...
Summer Flash Video MP3
This is a video I edited of Kent State's mascot, Flash, to Blue Man Group's Klein Mandelbrot. It was originally intended to be sent in with his entry to the Capitol ...
My Modular Origami Collection MP3
These are some of the modular origami I've made over the past year. (I forgot the Fuse spirals and boxes... and the 3D Swan... damn it...) You can find ...
Smash Brawl Online #12 MP3
CSHS Charger Band Show in 2 Minutes 2012 MP3
Power Wheels ReBuild MP3
Watch me Rebuild my Power Wheel, song: Klein Mandelbrot By Blue Man Group More crazy stuff http://www.modifiedpowerwheels.com.
Pack 250 Webelos Two Scouts Class of 2012 MP3
Blue Man Group - Feast Picking (live) MP3
from the "Live at The Venetian -- Las Vegas" digital album. "Feast Picking" is a re-done version of "Klein Mandelbrot" off the BMG album "Audio".
The Hardest Mandelbrot Zoom Ever!!! MP3
Mandelbrot Zoom Rekord :)
High Council Atramedes 10 Man Rogue Pov MP3
High Council Guild Atramedes 10 Man Song Blue Man Group, Klein Mandelbrot, I do not Clam or Own this song.
Pi and the Mandelbrot Set - Numberphile MP3
Thanks to Audible --- http://www.audible.com/numberphile This video features Dr Holly Krieger. Extra footage from this interview: https://youtu.be/r8Ksuc7T-VQ ...
My PVC Instrument Mega Mix (Take 1) MP3
I dug up my original mega mix video and found this first take of me playing my Mega Mix in the blue without the greenscreen. I guess you could say that it was ...
IKB neon on cloth (and some nice noise in the background), Art Core MP3
Esposizione all'Oscar bar, Novara. Telo dipinto, con neon foderati di blu. "Cubo musicale" con Arduino. Art Core: Martina Triolo, Luca Imbriani, Luca Cerina, ...
Episode 1-Internship MP3
Hope you enjoy this video about our summer internship made by our 2011 interns: Danielle Reinhard, Sarah Thomas, Steve Slater, Elliott O'Melia, and Micah ...
Pebble Beach and Monterey Automotive Week - 2013 MP3
Pi and Mandelbrot (extra footage) MP3
MAIN VIDEO: https://youtu.be/d0vY0CKYhPY More with Holly Krieger: http://bit.ly/HollyKrieger Objectivity: http://bit.ly/Objectivity NUMBERPHILE Website: ...
Times Tables, Mandelbrot and the Heart of Mathematics MP3
The good old times tables lead a very exciting secret life involving the infamous Mandelbrot set, the ubiquitous cardioid and a myriad of hidden beautiful patterns ...


text:
Garbage Removal
I have a tractor and dump trailer ready to work. I can clean property, grading, moving heavy things, trenches, prep work. Post holes, why do the work manually? Love yourself and take care of your body from heavy labor.
4 hour minimum.
Give us a call. Have pictures of previous work, and Referrals.

subset: commoncrawl


text:
Big companies today aren't creating nearly as many middle-class jobs. Instead they're hiring out much of the work to contractors around the world. But what if we could reverse engineer our technology to bring about a new era of local manufacturing in the U.S.? Economics correspondent Paul Solman talks with Jerry Davis, author of the new book "The Vanishing American Corporation." Continue reading
Three of Maria Sharapova's sponsors distanced themselves from the tennis star Tuesday after she announced failing a drug test at the Australian Open in January. Continue reading
In our news wrap Friday, President Obama visited the Oregon headquarters of athletic apparel company Nike to promote the Trans-Pacific Partnership. Also, the Labor Department reported that employers added 223,000 jobs in April, up from March. The unemployment rate dropped again, falling to 5.4 percent, the lowest since May 2008. Continue reading
Oregon Gov. Ted Kulongoski signed legislation Wednesday that will allow some legal rights for gay couples, joining nearly a dozen other states that recognize gay marriage or domestic partnerships. The NewsHour looks at the debate over same-sex civil unions. Continue reading


text:
CBS) Spaghetti and meatballs may not be the only things in some packages of Lean Cuisine Simple Favorites Spaghetti with Meatballs. The frozen entree's maker, Nestle, recalled the packages over fears they may contain pieces of red plastic.
The recalled packages bear the UPC code 13800-10390 with the production code 0298595519 P, the company said on its website.
The recall was announced after some customers reported finding the plastic pieces in the meatball portion of the entree. No injuries were reported.
The product should not be eaten, the company said. Customers who bought it can contact Nestle at 866 606 8264 or at firstname.lastname@example.com for more information and to receive a coupon for a replacement entree.


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Dr. Agnieszka Niemeyer MD Patient Reviews
- Dermatology Sequim, WA
Overall Rating
22 Patient Reviews
- Friendly Staff
- Promptness
- Wait Time 47.4 minutes
- Appropriate Followup
- Spends Time With Patients
- Bedside Manner
- Fair and Accurate Diagnosis
- Easy Appointments
Showing 1 - 12 reviews
2.0 of 5
July 15th, 2016
No one is worth waiting 2 hours to see.
5.0 of 5
December 13th, 2015
She diagnosed and healed something that troubled me for 30+ years
The doctor is excellent. The nursing staff not very impressive, reflecting for sure the population of the peninsula.
5.0 of 5
September 3rd, 2015
She's an exceptional doctor
Several of my friends had face cancers removed by Dr Niemeyer. She's such a skilled surgeon, a stranger would never guess they'd had deep, disfiguring lesions. Yes, sometimes the waiting is long, but she never rushes me through when it's MY turn.
5.0 of 5
June 15th, 2015
I'm receiving caring and skilled attention to my very difficult condition.
2.3 of 5
October 23rd, 2013
Great Doctor HORRIBLE Staff Member
Our family likes Dr. Niemeyer. Yes, there is always a long wait to see her, but she is worth waiting for. The problem at Paragon Dermatology is not the physician. The problem is 1 staff member who treats Dr. Niemeyer's patients horribly -- in a rude, unprofessional & demeaning manner. M.P. does NOT reflect the quality of professionals Dr. Niemeyer has a reputation for hiring. Dr. Niemeyer deserves better and her patients deserve better.
1.0 of 5
September 20th, 2013
Worst experience at a "doctors" office ever
I was early to fill out paperwork like requested. I waited 45 minutes after my appt time to be seen. I waited another 45 mins with no clothes on in a cold exam room. Finally this rude dr Niemeyer comes blasting in likes its my fault she has to work. Spins me around, doesn't discuss a thing with me and burns off two moles without as much as remark as to why. Worst doctor ever. I heard her say how she doesn't like Americans because we complain too much. She's a mean person.
1.0 of 5
July 8th, 2013
Bring a snack
She is always running late. She shows up 30-45mins late for her first appointment every day. She blames everything on the poor girl at the reception desk. If you even see the same girl for your next appt. She hires and fires them. If you complain, the staff just apologizes. They hear it everyday.
2.3 of 5
May 19th, 2011
just try, I dare you to get a refill on a prescription from this Dr. Five days and counting. Does not answer e-mail request from pharmacy, office staff promised to have it called in twice and.....still no script..nice!
1.0 of 5
August 3rd, 2010
Poor professionalism
My husband visited Dr. Niemeyer's office to have a skin check. He waited 2 hours on the first visit before he was able to get in to see the doctor. On the second visit two days later (waiting 45 minutes) for 2 biopsies, he received very unprofessinal treatment from the assistant who talked about another clinic where she had worked, talked about a patient they had just seen who was only given a couple months to live, called Dr. N the "biopsy queen" because she biopsies everything, realized she had forgotten to photograph the mole which was to be removed, and tried to make a decision about which one it was. When the doctor scraped the area, the sample fell on the floor and they proceeded to look for it. She then scraped another area near the area which we suppose was the area to be biopsied. When I called the doctor to complain about this treatment, she was rude ("What is it you want" -- as though she really didn't have time to talk to me), said she was doing us a favor to see my husband, and was defensive about the procedure, asking me if I really hadn't heard of a specimen jumping off the knife before. Then she told me she would send the results and for us to be sure to see another doctor next time before she hung up on me. A professional would never make you feel you were bothering her with taking time to see you or answer questions, let alone hang up on you.
5.0 of 5
June 2nd, 2010
Amazing and caring
Would strongly recommended. Friendly staff. Beautiful office. Smart, smart, smart doctor!!!!
1.0 of 5
April 27th, 2010
5.0 of 5
August 17th, 2017
Health Guides
Skin Cancer
Get the facts about skin cancer, including the different types and symptoms.
more health guides
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Dr. Agnieszka Niemeyer, MD is similar to these 3 Doctors near Sequim, WA.
Sequim, WA
Sequim, WA


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Earth Day 2016 – Trees for the Earth/
Earth Day 2016 will take place tomorrow, April 22, 2016, and this year's theme is Trees for the Earth - Let's Get Planting. Trees are critical in slowing climate change and creating a sustainable global future. Wildlife Alliance, through our Southern Cardamom Forest Protection Program and our Tropical Reforestation Project, is working to protect and rebuild the forests of the Southern Cardamom Mountain Range.
Forests are vital to slowing climate change because they act as carbon sinks, meaning they absorb more CO2 than they produce. Carbon dioxide is a major greenhouse gas that causes the earth's atmosphere to heat up. Forests also filter polluted air, providing people and wildlife with clean air to breathe. Over the last six years, Wildlife Alliance's forest protection program has conserved and protected 2 million acres of pristine forest and our Tropical Reforestation Project has planted over 917,000 trees. The Reforestation Project sites are all in areas that have been cleared of tropical forests. The clear-cut areas experience flooding, soil erosion and runoff, and are plagued by invasive weed species. In 2015, 760,273 seedlings were germinated in the Chi Phat shade net and 297, 071 seedlings were transferred from the Chi Phat nursery to multiple planting fields.
Forests are also vital to communities, helping them achieve economic and environmental sustainability. All of our projects employ local community members, providing them with a sustainable income. Wildlife Alliance works to alleviate poverty and stop the destruction of tropical forests throughout the Tropical Belt. In Cambodia alone, 8.2 million people rely on forest slash-and-burn practices. Wildlife Alliance is working with communities through our Community Agriculture Development Program to teach them sustainable farming practices and is employing other locals to reforest previously slashed areas.
Make a difference this Earth Day by making a gift to one of our forest programs!


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Marshlands Road, Moorends, Doncaster, DN8 4SZ
Telephone: 01405 818 787
Opening Times:
Mon to Sun: 5:00pm - 11:00pm
"Wednesday Offer - Four Courses For £8"
Date of Visit: Wednesday 25/05/16 - 5:30pm
Tandoori Mixed Starter £2.95
Sylheti Balti £6.95
Sabzi Sallom £6.50
Lamb Kazana £6.20
Plain Naan £1.60
Keema Naan £1.80
Kulcha Naan £1.80
Vegetable Pilau £2.10
Cup of Tea £?
We took advantage of the Wednesday offer of 4 courses (starter, main, rice or bread and a coffee or a tea) for £7.95. King Prawn dishes are not included.
The Tandoori Mixed Starter consisted of Seekh Kebab (3/5), Onion Bhaji (4/5) and Chicken Tikka (3/5). Pretty average starters to be fair. They didn't quite hit the heights of my last visit.
The Greyhounds Sabzi Sallom (4/5) was an enjoyable dish... spicy, not overly hot, but infused with delicious spices. Old Ironguts' Lamb Kazana (4/5) was a sweet dish and of good quality, but not quite what he was wanting. Afterwards, he did comment that he should have expected it to be a sweet dish due to a couple of the ingredients listed in the description. My Sylheti Balti (4/5) was a full, flavoursome dish which I thoroughly enjoyed.
The breads and rice were very good.
Awarded June 2015
"I Can't Fault It!"
Date of Visit: Tuesday 17/03/15 - 5:30pm
So, 3 days after our first visit, I found myself on a solo mission and arrived minus my two wingmen.
On Saturday, I thought that this establishment was first class but didn't have the energy to try and persuade my two mates that it was deserving of 5 stars. Tonight's visit confirmed it for me.
Tandoori Mixed Starter £2.95
Sabzi Sallom £6.50
Kulcha Naan £1.80
Vegetable Pilau £2.10 (untouched and taken home in a takeout container)
Cup of Tea £?
On Tuesday's and Wednesday's, they do a special offer of 4 courses for £7.95. That's any starter, any main, any naan or any rice and a cup of tea or coffee for less than eight quid. Please note, King Prawn dishes aren't included.
The Tandoori Mixed Starter consisted of Seekh Keebab, Onion Bhaji and Chicken Tikka. From Saturday, I knew that the SK and OB were good but the Chicken Tikka elevated it to new heights. The CT consisted of 3 great big chunks of marinated chicken; at most places you'd get just the one piece.
The Sabzi Sallom was as described, spicy - not hot, but infused by delicious spices.
I now understand why my mates raved about their Naan at the weekend… the Kulcha Naan was perfection. The Vegetable Rice I took home and had the next day - a spoonful in the restaurant revealed that it too was of outstanding quality.
Well deserving of five stars.
Awarded June 2015
"Hot House"
Date of Visit: Saturday 14/03/15; 7:30pm
In Hindi, Mirch means Chili. Mirchi can also means spicy hot, through chilies. Hot, will probably suffice as an English translation.
On this occasion we couldn't find a decent pre-meal watering hole. The two venues that we tried were quite pricey considering the fabric of the buildings and the ambiance within.
What's not to like? The "lads" travel in from Bradford. Starters, Mains and Sundries are all very sensibly priced… unlike some places!
Service was excellent, neither faked or disconcerting. The two chaps that we entered in to conversation with were engaging and affable.
They don't serve alcohol, but I'm sure one of my mates said that you can take your own. We didn't bother with poppadoms... and later, I'm sure that I heard one of the waiters ask a group of girls dining - "you'll not be bothered with poppadoms, will you?"
The non-intrusive background music took the edge off of the "emptiness", as we were the only diners when we took up our seats.
Seekh Keebab £2.20 (2 pieces)
Onion Bhaji £2.00 (2 pieces)
Gosht Karahi £5.95
Murgh Jalfrezi £5.95
Naga Surprise £6.45
Pilau Rice £1.75
Plain Naan £1.60
Puree (fried Chapati) 70p
The Seekh Kebab, as is so often the case, was of good quality but not spicy enough for us. The Onion Bhaji's were excellent, quite possibly the best that we have ever had.
My Naga Surprise, was just that; it was pretty much bang on the button. I'd probably rate it as a 5 star dish. It really was very, very good. All of the ingredients, were "cooked in to the dish" rather than being thrown in as an after thought.
The Gosht Karahi was also of a high standard, this friend rating the overall experience as four stars.
My other friends Murgh Jalfrezi looked good, but he wasn't too impressed with the sprinkling of raw Chili's and thought that the extra heat had been infused by use of a liberal dose of curry/chili powder.
I didn't have a Naan, though my two companions raved about theirs. A Naan next time for me then! The Puree (fried Chapati) were excellent and not often seen on menus in South Yorkshire. The Pilau Rice was of good quality, the saffron adding something extra to it.
We weren't asked if we wanted a dessert; as I don't think they do them. However, we were well sated and doubt that we had room.
I like this restaurant a lot and plan to return on Wednesday of this coming week? Why? Well, there are a number of dishes on the menu that you don't see on most South Yorkshire Indian Restaurants. These dishes remind me of Indo Lanka Fusion on Abbeydale Road in Sheffield.
On Tuesday's and Wednesday's, they (Mirchi) do 4 courses for £7.95!
A plus point for me, is that it's only a 10 minute detour on my journey home from work.
Roll on Wednesday!
I am not for turning and I look forward to dining here again on Wednesday!


text:
As rumors of the ASUS Padfone Mini increased in frequency, we were expecting an official unveiling soon. And right on cue, ASUS has just announced this smartphone+tablet hybrid with a relatively midrange hardware. Going against the conventional Padfone design, the ASUS Padfone Mini features a 4.3 inch smartphone which docks into the 7 inch tablet.
The tablet on the Padfone Mini packs a 7 inch 1280×800 display, while the display on the smartphone has a qHD resolution. The device also packs a quad core 1.4 GHz Snapdragon 400 chipset, an 8MP camera with the ASUS PixelMaster technology, 16GB of internal storage along with a microSD card slot and 1GB of RAM. The smartphone contains a 1,500 mAh battery while the tablet has a slightly bigger 2,200 mAh battery. The smartphone can be charged while docked into the tablet, which is certainly a neat touch.
The Padfone Mini combo runs Android 4.3 Jelly Bean with some customizations, so it's not entirely stock Android. Availability is currently limited to China, Russia, Taiwan, Hong Kong, Singapore and Indonesia with no word on European or North American launch just yet. Pricing has been set at NT$ 11,990 which is a touch over $400.
Via: Engadget


text:
Download Little kitten to share apk 1.1 free for Android smartphone
Posted by AndyMakerSpain in Entertainment | March 6, 2014 | 0 Comments
Apk file size: 14.0 MB
Collection of the most nice kittens to share with your friends and contacts.
You can share all these nice little kittens with your friends by e-mail, Whatsapp or Line.
Recommend them the application so that they too can find their favourite kitten and enjoy like you.
Offline support: enjoy with your favourite kittens even without any Internet connection available.
LEGAL NOTE: The ownership entity of this application reports that it contains images, some of which have been obtained over the Internet. These images are all public domain, since they are not identified by symbols or other information indicating the existence of exploitation rights reserved thereon. Notwithstanding this, a clear willingness to respect rights under Royal Legislative Decree 1/1996, of 12 April, approving the revised text of the Copyright Act, and compliance with the obligations imposed by Law 34/2002, of July 11, services of the information society and electronic commerce, the creator of this application calls to any natural or legal person to be the owner of any images contained therein, accrediting via email to firstname.lastname@example.com, committing the creator of the application to the immediate removal of said image after verifying, where applicable, the ownership of the protected image.
AndyMakerSpain part of our Entertainment and have average installs from 1000 to 5000. Last Update March 6, 2014. Google play rating is 75.6522. Current verison is 1.1. Actual size 14.0 MB.
Similar applications
Cat and Kitten Fun Meow Sounds1232 Comments


text:
Best practice strategies for validation of micro moulding process simulation
- Authors
- Publication Date
- Source
- Legacy
- Disciplines
The use of simulation for injection moulding design is a powerful tool which can be used up-front to avoid costly tooling modifications and reduce the number of mould trials. However, the accuracy of the simulation results depends on many component technologies and information, some of which can be easily controlled or known by the simulation analyst and others which are not easily known. For this reason, experimental validation studies are an important tool for establishing best practice methodologies for use during analysis set up on all future design projects. During the validation studies, detailed information about the moulding process is gathered and used to establish these methodologies. Whereas in routine design projects, these methodologies are then relied on to provide efficient but reliable working practices. Data analysis and simulations on preliminary micro-moulding experiments have been conducted. Numerous difficulties are identified which must be overcome for the accurate simulation of the micro-moulding process.


text:
- English
- français
Unified cluster expansion method applied to the configurational thermodynamics of cubic Ti1-xAlxN
We study the thermodynamics of cubic Ti1-xAlxN using a unified cluster expansion approach for the alloy problem. The purely configurational part of the alloy Hamiltonian is expanded in terms of concentration- and volume-dependent effective cluster interactions. By separate expansions of the chemical fixed lattice, and local lattice relaxation terms of the ordering energies, we demonstrate how the screened generalized perturbation method can be fruitfully combined with a concentration-dependent Connolly-Williams cluster expansion method. Utilizing the obtained Hamiltonian in Monte Carlo simulations we access the free energy of Ti1-xAlxN alloys and construct the isostructural phase diagram. The results show striking similarities with the previously obtained mean-field results: The metastable c-TiAlN is subject to coherent spinodal decomposition over a larger part of the concentration range, e.g., from x >= 0.33 at 2000 K.
- doi:10.1103/PhysRevB.83.104203
- View record in Web of Science
Keywords: Augmented-Wave Method ; Mechanical-Properties ; Thin-Films ; Alloys ; Ti ; Aluminum ; Coatings ; Titanium ; Systems
Record created on 2011-12-16, modified on 2016-08-09
Related material
- ICMP - Unattributed publications


text:
To add insult to injury during the Knicks huge loss to the Spurs (120-89), New York's Iman Shumpert's ankles got twisted up courtesy of Tony Parker.
Coming off a big block by Danny Green in the first quarter, Parker led the Spurs back on offense where he found himself one-on-one with Shumpert. What happened after was a massacre for Iman's ankles as well as his pride.
Check out TP crossing up Shumpert and blowing right past him for the easy bucket.


text:
Hello Friends,
Friday was the last day of my daughter´s school. Every year, last day we come home with teary eyes...:(
I made "Thank you" cards for her teachers.
I love to work with Dies and using felt and adding some embroidery is always my favourite thing.
It looks very handmade :))
Closer view
I´m linking this card in following challenges:
CAS on Sunday - Flower
CAS on Sunday - Flower
The Paper Players - Teacher thank you card.
Simon says Wednesday challenge : Anything goes
I love that´s crafty challenge blog - Keep it simple
Thanks for stopping by!!


text:
Kestrel House School
Catchment Area
Academic Results
Parents Forum
Buy & Sell
About Kestrel House School
Kestrel House School is a Independent school located in London. The Headteacher is Rosalind Norton.
The school supports special needs including: Aspergers Syndrome [archived], ASD - Autistic Spectrum Disorder
Contact Information
Other Info
- Type: Independent
- Headteacher: Ms Rosalind Norton
- Gender: Co-ed
- Total on roll: 23
School Catchment Area
Academic Results
Download the official OFSTED report for Kestrel House School
Parents Forum
New and exclusive to School Reviewer is our new parent's forum. Join other parents to discuss issues and topics that are relevant to your school, or join our national forum to discuss, ask or give advice on topics that matter to all parents. Get involved and start the conversation!
Buy & Sell
School Reviewer's new and unique Buy and Sell section Sell your child's outgrown uniforms, no longer needed books or any other items on your local selling platform. Welcome to the new and simple way to buy and sell unwanted school items.


text:
Hazardous Tree Report
Collect data about damaged trees that may need removal.
- iPhone, iPad
- Android
- Web, Desktop
About the App
The Hazardous Tree Report app allows tree managers or municipal public services agencies to mark the locations of trees that need pruning or removal, as they could be a hazard to nearby structures or features if they fall. Information can be reported about branch and trunk health, nearby features in danger of damage, as well as tree size.
Tree Species
Hazard Evaluation
Diameter of Tree (inches)
Treefall Hazards
Wounds in Tree
Root Health
Dead Branches
Other Defects


text:
1. Login to Hubdoc.
2. Select the Add Account button at the top of the Hubdoc Home screen.
3. Type in the name of the company you want to connect to Hubdoc. For example, American Express.
4. Enter in your credentials to login to that company's website.
5. Watch the magic as Hubdoc logs in and downloads all the historical documents available in your online account.
6. Hubdoc will create a folder with your company name. For example, American Express.
7. Hubdoc will automatically create subfolders for each account if you have multiple accounts with a company.
Hubdoc will pull in all sub-accounts associated with the online portal. you can choose which sub-accounts Hubdoc will fetch from by hiding accounts. To learn more about hiding accounts, Click Here.


text: Monica Fortunato OTR/L is a licensed Occupational Therapist with over 25 years of experience. She has spent the last 10 years working with children, teens and adults improving their handwriting skills. Monica and her programs have been featured in the LA Times, the Today in OT magazine and on BBC International Radio. She is Level One Certified by Handwriting Without Tears to evaluate and remediate handwriting difficulties. Monica works privately with children to remediate handwriting difficulties. Monica also works in schools providing Occupational Therapy services. Monica has worked with authors, physicians and business people to improve their handwriting legibility and confidence. Monica owns Handwriting Studio providing handwriting help to all ages.


text:
|Message view
|« Date » · « Thread »
|« Date » · « Thread »
|"Mark R. Diggory" <mdigg...@latte.harvard.edu>
|Re: [Jelly] Making jelly.bat a little smarter
|Wed, 01 Jan 2003 23:18:39 GMT
The big issue I recently ran into which caused me to suggest the changes to the jelly.bat file involved the configuration of services like log4j on JVM initialization. I seem to have to place the following on the classpath prior to initializing forehead for log4j to configure properly through forehead. A .bat file example (where log4j config file is in C:\xyz\conf\logconfig.xml): @echo off set CLASSPATH=C:\xyz\conf set FOREHEAD_CONF=C:\xyz\conf\forehead.conf set JELLY_OPTS=%JELLY_OPTS% -Dxyz.home=C:\xyz set JELLY_OPTS=%JELLY_OPTS% -Dlog4j.configuratorClass=org.apache.log4j.xml.DOMConfigurator set JELLY_OPTS=%JELLY_OPTS% -Dlog4j.configuration=logconfig.xml call %JELLY_HOME%\bin\jelly model.xml now I was hoping to get away with loading up the classpath in forehead like this in C:\xyz\conf\forehead.conf: +ant.home +jelly.home +xyz.home +tools.jar =[root] org.apache.commons.jelly.Jelly [root] ${xyz.home}/conf ${xyz.home}/classes ${xyz.home}/lib/*.jar ${jelly.home}/lib/*.jar ${ant.home}/lib/*.jar ${tools.jar} but it appears something is wrong because log4j attempts to fire up and fails to locate the logconfig.xml file on the classpath. I'm not exactly sure why this happens when it appears that the log4j jar isn't placed on the classpath until the forhead.conf file has been processed. I'll try it with classworlds and see if I get the same effect. -Mark bob mcwhirter wrote: > Ideally, we need to move Jelly to use classworlds instead of forehead > also. > > http://classworlds.werken.com/ > > Maven is making the move, as forehead was a only premature attempt to > solve a larger problem. classworlds solves the problem better, I believe. > > Your same suggestion applies though, regarding supplying alternate > launcher config files. > > -bob > > > > > On Fri, 27 Dec 2002, Mark R. Diggory wrote: > > >>Making jelly.bat support alternate sources for forehead.conf would good >>as well. This allows for addition of jars to the classpath when its >>unfeasable to place them into the jelly/custom directory. >> >> >>@echo off >> >>if "%FOREHEAD_CONF%"=="" set FOREHEAD_CONF=%JELLY_HOME%\bin\forehead.conf >> >>%JAVA_HOME%\bin\java -classpath >>%CLASSPATH%;%JELLY_HOME%\lib\forehead.jar >>-Dforehead.conf.file=%FOREHEAD_CONF% -Dant.home=%ANT_HOME% >>-Djelly.home=%JELLY_HOME% -Dtools.jar=%JAVA_HOME%\lib\tools.jar >>%JELLY_OPTS% com.werken.forehead.Forehead %* >> >> >>---- >>Mark >> >> >>-- >>To unsubscribe, e-mail: <mailto:firstname.lastname@example.com> >>For additional commands, e-mail: <mailto:email@example.com> >> > > -- > Bob McWhirter firstname.lastname@example.com > The Werken Company http://werken.com/ > > > -- > To unsubscribe, e-mail: <mailto:firstname.lastname@example.com> > For additional commands, e-mail: <mailto:firstname.lastname@example.com> > -- To unsubscribe, e-mail: <mailto:email@example.com> For additional commands, e-mail: <mailto:email@example.com>
|View raw message


text:
The songs in Pree's upcoming album, Rima (which takes its name from geologic fissures on the moon), feature a series of interpersonal confrontation--interactions enhanced and at times distorted by the narrator's own fractured understanding of others. They are sent off in an outpouring of letters centered around longing and expectation, whose imposing jaws are often only capable of ensnaring disappointment and heartbreak. They reveal truths in a harsh light, at times exposing wide expanses between friends and intimates who have spent time enough apart to approach each other with near-scientific objectivity. Other expanses, still narrow and tender, take the form of defensive trenches or reasons to raise one's voice to a figure not yet out of earshot.
Whether the gaps have taken a lifetime to develop or appear abruptly and perhaps through self-infliction, the letters in Rima remain unanswered, prompting the sender to draw her own conclusions regarding those close to her. The album is a study in these divergences of personal relationships and how the narrator copes with their implications as she seeks to define herself and determine what to leave behind and what is worth hanging onto.
Pree is:
Ben Usie
May Tabol
Benjamin Schurr
Album/Website Artwork Courtesy of Rhona L.K. Schonwald
Photo: Shervin Lainez


text:
Vanquis Credit Card
43 reviews from the community
Review of "Vanquis Credit Card"
"Vanquis Credit Card Does what it says"
I applied for a Vanquis Card in December 2009 and at the time had a few defaults and CCJ's registered against me. I applied for the card as I wanted to build my credit back up, plain and simple.After sending off proof of my identity in a pre-paid envelope they provided I received my card at the beginning of January 2010 with a credit limit of £250.
I used the card to pay for my normal everyday stuff that Ii would spend anyway and every month I would repay the balance in full. This has cost me NOTHING extra other than what I have spent... Basically a 0% Interest rate!!!!In July 2010 I received a text message on my mobile and a letter in the post confirming my new Credit limit of £1,000. I didn't ask for this increase (You can't ask anyway), but I was pleasantly suprised since my defaults and CCJ's wont expire until 2013.
I still use the card every month and I only spend what I can comfortably afford to pay back. This means I still pay 0% on my card since January 2010.I think their customer service is excellent but it does take a while to get through. The payment via debit card using automated systems is quick and usually authorises within seconds. Overall I am really grateful for the card as it helps to improve my credit and doesn't cost me a penny to do it!!
I would not like to pay the 34.9% interest charges if I didn't pay my balance in full each month though. I don't care about rewards or anything like that at present. I am a sub-prime borrower and I am just grateful Vanquis have given me the opportunity to rebuild my credit file when so many others would not.
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Pegfilgrastim prophylaxis is associated with a lower risk of hospitalization of cancer patients than filgrastim prophylaxis: a retrospective United States claims analysis of granulocyte colony-stimulating factors (G-CSF)
Clinical and radiation oncology
Myelosuppressive chemotherapy can lead to dose-limiting febrile neutropenia. Prophylactic use of recombinant human G-CSF such as daily filgrastim and once-per-cycle pegfilgrastim may reduce the incidence of febrile neutropenia. This comparative study examined the effect of pegfilgrastim versus daily filgrastim on the risk of hospitalization.
This retrospective United States claims analysis utilized 2004–2009 data for filgrastim- and pegfilgrastim-treated patients receiving chemotherapy for non-Hodgkin's lymphoma (NHL) or breast, lung, ovarian, or colorectal cancers. Cycles in which pegfilgrastim or filgrastim was administered within 5 days from initiation of chemotherapy (considered to represent prophylaxis) were pooled for analysis. Neutropenia-related hospitalization and other healthcare encounters were defined with a "narrow" criterion for claims with an ICD-9 code for neutropenia and with a "broad" criterion for claims with an ICD-9 code for neutropenia, fever, or infection. Odds ratios (OR) for hospitalization and 95% confidence intervals (CI) were estimated by generalized estimating equation (GEE) models and adjusted for patient, tumor, and treatment characteristics. Per-cycle healthcare utilization and costs were examined for cycles with pegfilgrastim or filgrastim prophylaxis.
We identified 3,535 patients receiving G-CSF prophylaxis, representing 12,056 chemotherapy cycles (11,683 pegfilgrastim, 373 filgrastim). The mean duration of filgrastim prophylaxis in the sample was 4.8 days. The mean duration of pegfilgrastim prophylaxis in the sample was 1.0 day, consistent with the recommended dosage of pegfilgrastim - a single injection once per chemotherapy cycle. Cycles with prophylactic pegfilgrastim were associated with a decreased risk of neutropenia-related hospitalization (narrow definition: OR = 0.43, 95% CI: 0.16–1.13; broad definition: OR = 0.38, 95% CI: 0.24–0.59) and all-cause hospitalization (OR = 0.50, 95% CI: 0.35–0.72) versus cycles with prophylactic filgrastim. For neutropenia-related utilization by setting of care, there were more ambulatory visits and hospitalizations per cycle associated with filgrastim prophylaxis than with pegfilgrastim prophylaxis. Mean per-cycle neutropenia-related costs were also higher with prophylactic filgrastim than with prophylactic pegfilgrastim.
In this comparative effectiveness study, pegfilgrastim prophylaxis was associated with a reduced risk of neutropenia-related or all-cause hospitalization relative to filgrastim prophylaxis.
Patients receiving myelosuppressive chemotherapy are at risk of developing febrile neutropenia, a major dose-limiting toxicity of systemic chemotherapy associated with hospitalization, use of intravenous antibiotics, and significant morbidity, mortality, and costs
Filgrastim is recommended to be administered at a recommended starting dose of 5 mcg/kg per day until neutrophil recovery occurs after the expected chemotherapy-induced nadir. Its short circulating half-life (~3.5 hours) necessitates that it be given daily. The efficacy of filgrastim depends on the number of days it is administered. Randomized comparative clinical trials have shown that patients treated with a mean of 10–11 filgrastim doses per chemotherapy cycle reported a similar decrease in the duration of severe neutropenia as patients treated with pegfilgrastim once per chemotherapy cycle
Neutropenic complications following chemotherapy contribute significantly to the costs of cancer care. During 1989–2007, the number of neutropenia-related hospitalizations among cancer patients in the United States was estimated to be approximately 57,000–103,000 per year
The primary objective of the current study was to determine whether a difference in the risk of neutropenia-related and all-cause hospitalization between chemotherapy cycles associated with filgrastim prophylaxis and cycles with pegfilgrastim prophylaxis. This study from a United States claims database included data from January 2004 through February 2009 regarding filgrastim and pegfilgrastim administration patterns and related clinical outcomes. Additionally, economic data in the form of comparative healthcare utilization and costs results are described.
Study design
This study was a retrospective United States claims analysis using data from health plans affiliated with OptumInsight (formally Ingenix). This national database contains both medical and pharmacy claims with linked enrollment information data beginning in 1993. As of 2008, medical and pharmacy benefit coverage information was available for over 14 million individuals.
All patient-identifying information was either encrypted or removed from the study database prior to its release to the study investigators. The study database does not contain any Protected Health Information and is fully compliant with the Health Insurance Portability and Accountability Act (HIPAA) of 1996 and federal guidance on Public Welfare and the Protection of Human Subjects
Outcomes, including administration patterns, neutropenia-related and all-cause hospitalization rates, and utilization and cost data, were obtained for both filgrastim- and pegfilgrastim-treated patients receiving chemotherapy for non-Hodgkin's lymphoma (NHL), breast cancer, lung cancer, ovarian cancer, or colorectal cancer.
Patients with chemotherapy medical claims between January 1, 2005 and February 28, 2009 were studied. The year prior to the index date was used to determine whether patients met inclusion/exclusion criteria and to provide demographic and patient characteristic data. The date of the first chemotherapy claim of an eligible patient was deemed the index date. Patients were included if they had two or more medical claims ( ≥ 7 days apart) with ICD-9 code(s) for NHL, breast cancer, lung cancer, ovarian cancer, or colorectal cancer from 30 days prior to the index date up to 30 days after the index date, and one or more claim for filgrastim or pegfilgrastim (not both) during the chemotherapy course. Claims from laboratories, diagnostic testing centers, or any diagnostic tests were not considered when identifying cancer patients, as well as claims with "rule-out" codes (CPT-4 codes 36400–36425, 70010–76999, 7800–78799, 80000–89999; HCPCS codes S9529, G0001). Patients were excluded if they had less than 1 year of continuous eligibility preceding the index date; any claim for chemotherapy during the 1 year prior to the index date; one or more medical claims for bone marrow or stem cell transplant; claims indicating sargramostim use; claims for services provided in skilled nursing facility or hospice services; or if they had codes for more than one type of primary cancer. Patients with metastatic disease were not specifically excluded.
Besides tumor type and use of pegfilgrastim/filgrastim, data collected also included demographic characteristics, comorbid conditions, cancer treatment history, and chemotherapy agents received in each chemotherapy cycle. The first eligible chemotherapy course for each patient after January 1, 2005 was used in this analysis. Each chemotherapy course may include several cycles. The first chemotherapy course began on the index date and ended with any of the following, whichever came first: 1) the absence of any chemotherapy claims within the 60 days after a chemotherapy claim (ie, chemotherapy gap); 2) the end of insurance eligibility or study period; or 3) the initiation of radiation therapy. Chemotherapy cycles in the course were defined to identify unique cycles of interest, and were excluded if two chemotherapy claims had less than 20 days between them or if there were chemotherapy claims from days 7–19 of a cycle
For both filgrastim and pegfilgrastim, use was categorized as prophylactic (ie, initiated on or before day 5 of a cycle) or delayed (initiated after day 5 of a cycle)
Additional file 1
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Utilization and cost data
Healthcare utilization and costs were calculated for each cycle. Total all-cause costs were calculated as the costs associated with all medical and pharmacy claims during the cycle. Physician fees, chemotherapy costs, and G-CSF costs were all included in the total all-cause cost measure. Additionally, all-cause utilization and costs were calculated separately for emergency room (ER) visits, hospitalizations, and ambulatory care visits (outpatient hospital and office-based visits). Hospitalization length of stay was another examined utilization outcome. Drugs delivered as part of medical benefits (eg, administered chemotherapy) were included in the costs for each setting of care: ER, hospital inpatient, and ambulatory care. Retail pharmacy costs were calculated as the cost for all prescription claims and considered as a component of total costs in the ambulatory care setting. Neutropenia-related utilization and costs were calculated from claims associated with neutropenia. The costs represented the reimbursed amount paid by the patient and insurer. Only direct costs for services covered under the patient's insurance benefit were included in this study.
Statistical analyses
Descriptive statistics regarding patient characteristics and cycle characteristics (in terms of chemotherapy agents received and G-CSF administration patterns) were calculated for filgrastim and pegfilgrastim separately. Additionally, descriptive statistics were calculated for healthcare utilization, costs, and length of hospital stay during cycles with filgrastim or pegfilgrastim prophylaxis. Statistical tests were used based on the distribution of the data (eg, t-test for continuous variables and chi-squared test for categorical data). Odds ratios (OR) and 95% confidence intervals (CI) for hospitalization in cycles with pegfilgrastim prophylaxis compared to cycles with filgrastim prophylaxis were estimated by generalized estimating equation (GEE) models. The GEE models included up to the ninth chemotherapy cycle for each patient. This restriction was included because failure to do so resulted in GEE model estimation that failed to converge. A binomial distribution with log link was specified for all GEEs, and the models were fit using an exchangeable correlation structure. To control for possible confounding between G-CSF agent and outcomes, ORs were adjusted for patient age and sex, cancer type, myelotoxicity of chemotherapy, chronic comorbidities (as assessed with the Quan-Charlson comorbidity index
Sensitivity analysis
Sensitivity analyses were performed to determine whether other factors could affect the results. First, we examined the impact of excluding filgrastim cycles with a shorter duration (ie, less than 4 days of filgrastim prophylaxis) of filgrastim prophylaxis. Second, as the exclusion of patients with evidence of more than one primary cancer could inappropriately exclude patients with only one primary cancer (in case metastases were inappropriately coded as additional primary cancers), that criterion was removed.
Patient characteristics
The initial population from the claims database contained 151,118 patients receiving chemotherapy. After applying the inclusion and exclusion criteria, the eligible population included 3,535 patients with breast cancer, lung cancer, NHL, ovarian cancer, or colorectal cancer receiving G-CSF prophylaxis. These patients represented 12,056 cycles during which G-CSF was delivered prophylactically, including 373 filgrastim cycles and 11,683 pegfilgrastim cycles (Table
Risk of hospitalization
Hospitalization data for a narrow definition of neutropenia, a broad definition of neutropenia, and all causes were calculated and are described herein. The incidence of neutropenia-related hospitalization (narrow definition) per cycle was 1.3% (95% CI: 0.4%–3.1%) with prophylactic filgrastim and 0.6% (95% CI: 0.5%–0.7%) with prophylactic pegfilgrastim (P = 0.063); neutropenia-related hospitalization (broad definition) per cycle also occurred at a higher incidence with prophylactic filgrastim than with prophylactic pegfilgrastim (6.7% [95% CI: 4.4%–9.7%] vs. 2.4% [95% CI: 2.1%–2.7%], P < 0.001); a higher incidence with prophylactic filgrastim than with prophylactic pegfilgrastim in all-cause hospitalizations per cycle was observed as well (10.2% [95% CI: 7.3%–13.7%] vs. 5.0% [95% CI: 4.6%–5.4%], P < 0.001).
When compared with cycles in which filgrastim was prophylactically used, cycles in which prophylactic pegfilgrastim was used were associated with a reduction in the risk of all-cause hospitalizations (odds ratio [OR] of 0.50, 95% CI: 0.35–0.72, P < 0.001) and neutropenia-related hospitalization (narrow definition: OR: 0.43, 95% CI: 0.16–1.13, P = 0.087; broad definition: OR: 0.38, 95% CI: 0.24-0.59, P < 0.001), after controlling for patient, disease, and treatment characteristics in GEE models (Table
Figure 1
Odds ratios for neutropenia-related and all-cause hospitalization regarding prophylactic pegfilgrastim versus prophylactic filgrastim
Odds ratios for neutropenia-related and all-cause hospitalization regarding prophylactic pegfilgrastim versus prophylactic filgrastim. Odds ratios (ORs) and 95% confidence intervals (95% CI) for hospitalization are shown with pegfilgrastim versus filgrastim prophylaxis, adjusted for patient, cancer, and chemotherapy characteristics. The primary analysis included all cycles in which G-CSF was used prophylactically. The subgroup analysis only included those cycles in which patients received 4 or more days of filgrastim (as described in the Methods section under "Sensitivity Analyses").
Sensitivity analyses were conducted to examine the possible effects of length of filgrastim prophylaxis and the presence of more than one primary cancer. Hospitalization risk for cycles in which filgrastim was used for 4 or more days was examined. The OR for the comparison between filgrastim and pegfilgrastim did not change appreciably from those observed in the primary analysis (Figure
Healthcare utilization and costs
Healthcare resource utilization and costs on a per-cycle basis were examined for neutropenia-related causes (with both the broad and narrow criteria for neutropenia) and all causes (Table
For neutropenia-related utilization per cycle for all cycles (including cycles without neutropenia-related utilization), there were more ambulatory visits (2.1 vs. 0.36 per cycle, P < 0.001) and hospitalizations (0.02 vs. 0.01 per cycle, P = 0.146) with filgrastim than with pegfilgrastim (mean ER visits were 0 for both groups). In the subset of filgrastim cycles in which neutropenia-related hospitalization occurred (5 cycles, 1.34% among all 373 filgrastim cycles), an average of 1.4 neutropenia-related hospitalizations occurred per cycle, with mean length of stay of 12.6 days. In the subset of pegfilgrastim cycles in which neutropenia-related hospitalization occurred (68 cycles, 0.58% among all 11,683 pegfilgrastim cycles), an average of 1.0 neutropenia-related hospitalization occurred per cycle, lasting a mean of 7.0 days each. Among all filgrastim cycles, 39.7% were associated with at least one neutropenia-related ambulatory visit; the corresponding percentage among all pegfilgrastim cycles was 28.0%. During the subset of cycles in which these neutropenia-related ambulatory visits occurred, the mean number of neutropenia-related visits was 5.3 for filgrastim cycles and 1.3 for pegfilgrastim cycles. All-cause resource utilization showed similar trends as that indicated for neutropenia-related results, and specific all-cause healthcare utilization results can be seen in Table
Per-cycle costs were also examined by setting of care: ambulatory care, ER, and inpatient hospitalizations (Figure
Figure 2
Costs per cycle: All-cause and neutropenia-related
Costs per cycle: All-cause and neutropenia-related. Healthcare resource costs, for cycles in which pegfilgrastim and filgrastim were used prophylactically, were calculated on a per-cycle basis to provide total costs as well as subgroup costs by setting of care: ambulatory care, emergency room, and hospitalizations. The costs were direct costs for services covered under patients' insurance benefits and represented the reimbursed amount paid by the patient and insurer.
The combined mean costs per cycle due to all cause for all cycles were fairly similar for the two G-CSF molecules, with $9,575 for filgrastim and $9,786 for pegfilgrastim (P = 0.756). Compared to pegfilgrastim, there were lower ambulatory care costs for filgrastim ($7,788 vs. $8,933, P = 0.004) and greater hospitalization costs for filgrastim ($1,769 vs. $815, P = 0.054).
In this retrospective United States claims analysis, use of prophylactic pegfilgrastim was associated with a decreased risk of neutropenia-related hospitalization (narrow definition: OR = 0.43, 95% CI: 0.16–1.13; broad definition: OR = 0.38, 95% CI: 0.24–0.59) and all-cause hospitalization (OR = 0.50, 95% CI: 0.35–0.72) when compared to that seen with the use of prophylactic filgrastim. Patients who received filgrastim prophylaxis in this study had a mean 4.8 days of prophylaxis, which is much shorter than the duration which has been demonstrated to be non-inferior to pegfilgrastim prophylaxis in clinical trials
In a previous study that used a large managed care claims database in the United States, Weycker et al. performed a retrospective cohort analysis of cancer patients who received filgrastim or pegfilgrastim during their first course of chemotherapy (2003–2005)
One distinct aspect of this study is that comparative filgrastim and pegfilgrastim costs and resource utilization data were reported, including details such as the number of hospitalizations, ambulatory and ER visits, and per-cycle costs. Comparative studies assessing cost and resource utilization of filgrastim and pegfilgrastim in the United States are limited. A retrospective single-time-point survey conducted by Fortner et al. assessed the human resource costs required for administering filgrastim or pegfilgrastim
In this study utilizing a large claims database, all-cause costs were roughly equivalent for filgrastim and pegfilgrastim on a per-cycle basis, with more spent on hospitalizations with filgrastim and more spent on ambulatory care with pegfilgrastim. It is interesting to note that although pegfilgrastim cycles had greater costs for ambulatory care, there were proportionally more ambulatory visits for filgrastim cycles. The increased all-cause per-cycle cost of pegfilgrastim ambulatory care may reflect the greater drug costs of pegfilgrastim compared to filgrastim, especially when fewer than the recommended number of filgrastim doses were administered. Neutropenia-related costs were greater for filgrastim than pegfilgrastim because of the greater costs of both inpatient and ambulatory care during filgrastim cycles. Overall, these data suggest that the greater drug costs with pegfilgrastim are offset by decreased hospitalization costs.
There are several sources of bias and limitations inherent in the study design that could influence interpretation of these results. As this was a database of a large employment-sponsored managed care population, patients would most likely be in the 18–64 year age range. Thus, the effects of G-CSF on outcomes in the population of patients aged 65 years or above were not fully captured. Additionally, the data are dependent on the accuracy of claims coding and hence contain any errors or omissions that occurred during that coding. By using the broad criteria for neutropenia, as well as all-cause utilization, we were able to more accurately provide upper limits for our estimates. It should be noted that this study compared risk between treatment cohorts. The potential under-coding and mistakes in coding of febrile neutropenia are unlikely to be associated with G-CSF selection and thus do not affect the estimates of interest (ie, ORs). Sample size is another issue that affects the statistical power of our estimates, as there were fewer than 400 cycles with prophylactic filgrastim use. Another source of bias is the assumption that G-CSF administration by day 5 of a cycle represents prophylaxis rather than treatment. Although this definition has been used in other studies
It is unclear whether this study adequately captured the various known patient, disease, and treatment characteristics that are risk factors for developing febrile neutropenia
The use of per-cycle analyses for utilization and costs has the disadvantage of not capturing costs associated with cycles in which G-CSF was not administered. However, per-patient analyses would not allow us to temporally associate use of either G-CSF with utilization. For instance, in a per-patient analysis, a patient hospitalized in cycle 1 who subsequently received G-CSF in cycle 2 would have those two events associated, when clearly the hospitalization was independent of any effects from G-CSF. Another disadvantage of per-patient analyses is that while on average, each patient who received filgrastim received it for a mean of 2.3 cycles, while each patient who received pegfilgrastim received it for a mean of 3.5 cycles. The accompanying drug costs would make it difficult to discern any possible effect of either medication on all-cause medical costs.
In conclusion, the results of this claims analysis indicate that prophylactic use of filgrastim as compared with pegfilgrastim is associated with an increased risk of hospitalization from all causes as well as neutropenia-related causes. Results from this analysis and others indicate that other factors influence the risk of hospitalization, including comorbidities, history of anemia, age, and presence of metastatic disease
This retrospective comparative effectiveness study used claims data to examine prophylactic use of filgrastim and pegfilgrastim in cancer patients receiving chemotherapy. The key finding of the study is that pegfilgrastim prophylaxis was associated with a reduced risk of hospitalization due to neutropenia or all-cause.
Competing interests
In addition to the relationships with Amgen Inc. described in the Acknowledgements, Henry Henk and Laura Becker are employees of OptumInsight, while Victoria Chia, Sejal Badre, Xiaoyan Li, and Robert Deeter are stockholders of Amgen Inc.
Authors' contributions
All authors contributed to study design and analysis and interpretation of data. HH and LB were primarily responsible for data acquisition. All authors read and approved the final manuscript.
Funding for this study was provided by Amgen Inc. Victoria Chia, Sejal Badre, and Xiaoyan Li are employees of Amgen Inc., while Arash Naeim, Henry Henk, and Laura Becker are consultants for Amgen Inc. Robert Deeter was an employee of Amgen Inc. at the time this study was conducted. Medical writing assistance was provided by Susanna Mac and Michelle Zakson, who are employees of Amgen Inc.
Incidence, cost, and mortality of neutropenia hospitalization associated with chemotherapy
Chemotherapy-induced neutropenia: risks, consequences, and new directions for its management
Mortality, morbidity, and cost associated with febrile neutropenia in adult cancer patients
The economics of febrile neutropenia: implications for the use of colony-stimulating factors
Filgrastim in patients with neutropenia: potential effects on quality of life
Risk models for predicting chemotherapy-induced neutropenia
Cost of neutropenic complications of chemotherapy
Economic burden of chemotherapy-related febrile neutropenia
Costs and outcomes associated with hospitalized cancer patients with neutropenic complications: A retrospective study
Trends in Neutropenia-Related Inpatient Events
2006 update of recommendations for the use of white blood cell growth factors: an evidence-based clinical practice guideline
A randomized double-blind multicenter phase III study of fixed-dose single-administration pegfilgrastim versus daily filgrastim in patients receiving myelosuppressive chemotherapy
Open-label, randomized study of pegfilgrastim vs. daily filgrastim as an adjunct to chemotherapy in elderly patients with non-Hodgkin's lymphoma
Comparable efficacy and safety profiles of once-per-cycle pegfilgrastim and daily injection filgrastim in chemotherapy-induced neutropenia: a multicenter dose-finding study in women with breast cancer
Blinded, randomized, multicenter study to evaluate single administration pegfilgrastim once per cycle versus daily filgrastim as an adjunct to chemotherapy in patients with high-risk stage II or stage III/IV breast cancer
Randomized, multicenter, open-label study of pegfilgrastim compared with daily filgrastim after chemotherapy for lymphoma
Are shorter courses of filgrastim prophylaxis associated with increased risk of hospitalization?
Observational study of the prevalence of febrile neutropenia in patients who received filgrastim or pegfilgrastim associated with 3–4 week chemotherapy regimens in community oncology practices
Risk of hospitalization for neutropenic complications of chemotherapy in patients with primary solid tumors receiving pegfilgrastim or filgrastim prophylaxis: a retrospective cohort study
Comparative effectiveness of colony-stimulating factors for febrile neutropenia: a retrospective study
Comparative effectiveness of filgrastim, pegfilgrastim, and sargramostim as prophylaxis against hospitalization for neutropenic complications in patients with cancer receiving chemotherapy
Code Fed Regul Public Welfare 1995
Health Insurance Portability and Accountability Act of 1996. Public Law 104–191
Coding algorithms for defining comorbidities in ICD-9-CM and ICD-10 administrative data
Costs of human resources in delivering cancer chemotherapy and managing chemotherapy-induced neutropenia in community practice
Risks and consequences of chemotherapy-induced neutropenia
Pre-publication history
The pre-publication history for this paper can be accessed here:


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Home▶ Palm/Ponga Stacker Mug
Palm/Ponga Stacker Mug
We love a good stacker mug here at Coffee Supreme. So we designed and printed three new designs as part of our We Down Here summer 2017 range.
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Also available in the set are the
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Our CSR objectives are as follows:
- Promoting healthcare facilities for the upliftment of people at large and creating a positive impact by addressing issues of accessibility and affordability;
- Promoting educational facilities to help and assist in unfolding the talent of children and amateurs; and
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We have undertaken the following projects:
- Railway clinics: We have established free emergency medical centres within railway stations which provide basic health services and basic medicines primarily to the railway passengers. We operate 4 such clinics.
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Our CSR activities are monitored by the CSR Committee of our Board.


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Women today appear to be more accepting of their bodies in regard to weight than in the past, new research has found.
"While women consistently report being more dissatisfied with their bodies than men as far as thinness is concerned, that dissatisfaction has decreased over the 31-year period we studied," said Bryan Karazsia from the College of Wooster in the US.
"Body dissatisfaction is not only a common predictor of eating disorders, such as anorexia nervosa and binge eating, but also can play a role in the development of depression,"
Studies conducted in the 1990s suggested that the percentage of women who were unhappy with their weight was on the rise. For the new study, researchers conducted a meta-analysis of more than 250 studies representing 100,228 participants from 1981 to 2012, to analyse trends on how people felt about their bodies, specifically in regard to weight.
They found that while women consistently were more dissatisfied than men, their dissatisfaction gradually declined over time, while men's dissatisfaction remained relatively constant throughout.
Since men's body image issues are not always about thinness and can often be related to musculature, researchers also conducted a similar meta-analysis, this time focusing on muscle size.
They analysed 81 studies representing more than 23,000 participants over a 14-year span. Researchers found that men regularly reported more body dissatisfaction than women when it came to muscularity but, over time, levels remained relatively consistent for both men and women.
According to Karazsia, the findings represent a positive change in the social pressures that women face toward more body acceptance and body diversity.
"The last two decades have witnessed increasing attention and awareness on a body acceptance movement aimed primarily at girls and women," he said. "That, combined with increased media visibility of role models who run counter to the trend towards thinness, may, in part, help explain their findings," he added.


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Dr. David Tanner DO Patient Reviews
- Osteopathic Manipulative Medicine Boulder, CO
Overall Rating
11 Patient Reviews
- Friendly Staff
- Promptness
- Wait Time 22 minutes
- Appropriate Followup
- Spends Time With Patients
- Bedside Manner
- Fair and Accurate Diagnosis
- Easy Appointments
Showing 1 - 11 reviews
1.0 of 5
June 5th, 2015
He is 30 - 40 minutes late every morning, leaves at 3 thirty, doesn't work on Fridays and has taken 2 vacations in the past six months, yet he thinks his patients should see him twice a week and his physical therapist once a week. He does not respect your time, but his is paramount. He spoke to me on a few occasions in a disrespectful manner. The last time he told me I was on thin ice and everybody in his office had an Issue with me. It was reminiscent of a child who wasn't getting his way so he was going to take his soccer ball home and end the game. He insisted my problems were due to my migraines, regardless of the fact I told him I only got migraines once or twice a year since I had a hysterectomy 10 years ago. He did not listen and blamed me when he forgot something about my case. Lastly, he was angry with me because I was going out of town and needed my prescriptions one day early. He spoke angrily to me for about 10 minutes, then he decreased the dosage of my medicines as punishment. He then, threatened me when I returned from my vacation he was going to decrease the dosage of my medicines even more. If you love yourself, then spare yourself the behavour of this man.
1.0 of 5
April 25th, 2014
disrespectful, arrogant.
Bad experience, Do not see him. Would spend less than10 minuets with you or just put pressure on the back of your neck for few minuets. Usually Late for you're appointment's or has his assistant do PT to cover for him..Than he has you come in at least two times a week, and they refuse to tell you how much they charge. Witch is twice as much as any other doctor I have been to..By the time you get the bill you realize what a scam it is. Hopefully you can get in some ware else soon. Because if you try to change or cancel appointments he will treat you like a child and humiliate you.. The girls up front aren't any better.. Very expensive..DON'T WAST YOU'R TIME OR MONEY.....!!!!!
1.0 of 5
July 8th, 2013
BAD clinic
I was referred to this clinic for my migraines by a friend and she suggested I see Dr. Reish. I decided to see his colleague Dr. Tanner because he could get me in sooner...BIG MISTAKE. Despite having filled out all my paperwork before going in, I sat and waited for nearly 45 minutes before the doctor came to see me. The office was disorganized and nobody apologized for my wait. He didn't seem willing to hear me out that I would be unable to come to his office 2 times a week for Physical Therapy and wanted to look at other options. I decided I wasn't coming back. This was in May and I have yet to receive a billing statement from their office. I called and spoke with Jackie once and she promised to get back to me but now just dodges my calls. A call to my insurance company helped me find out that they didn't even have record of my visit until 3 weeks after I was seen because it hadn't been billed out yet. A VERY POORLY RUN OFFICE!
1.0 of 5
June 17th, 2013
Doctor seems to have a one size fits all approach to treating patients, which anyone who know migraine knows that is a poor system. He let me wait for 35 minutes, and then gave me a lecture about migraines . Waste of time.
2.3 of 5
November 19th, 2012
Dr. Tanner may be great butbthe staff
5.0 of 5
October 8th, 2010
Dr. David Tanner has been a life saver for my husband with Closed Head Injury (from an auto accident) and Lower Back and Neck problems along with TMJ. Dr.Tanner has his techniques and he was able to Bring my husband back to be able to live a more normal life. He worked very closely with my husband and after 2 years of extensive therapy my husband feels better than he did before starting with Dr. Tanner. Unfortunately we had to Move to Maryland and now we may mover to Colby Kansas and go back to see Dr.Tanner as he is worth the 31/2 hour drive every month! I hoope to see you again soon Doc! I'm happy you are still in area! :o)
5.0 of 5
August 30th, 2008
amazing treatment
5.0 of 5
April 8th, 2016
5.0 of 5
July 27th, 2015
5.0 of 5
April 1st, 2015
1.0 of 5
January 2nd, 2010
Health Guides
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Dr. David Tanner, DO is similar to these 3 Doctors near Boulder, CO.
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Manufacturing General Manager
- Recruiter
- Concorde Group
- Location
- Truro
- Salary
- £55K + bens
- Posted
- 15 Jun 2017
- Expires
- 21 Jun 2017
- Sector
- Engineering
Highly respected engineering/manufacturing company based near Truro, Cornwall are looking to recruit a permanent General Manager. Duties and responsibilities to include: ·Manage policy deployment in the areas of lean manufacturing techniques, quality, cost reduction, complete and on-time delivery, customer satisfaction, employee relations, visual controls and plant performance measures. ·Develop and manage operating budget to achieve company performance and EBITDA ·Provide leadership for employee relations through effective communications, coaching, training and development. ·Provide leadership for problem resolution to facilitate fast improvements and improved working relationships. ·Manage material requirements to increase inventory turns and reduce levels on hand. ·Ensure compliance with standards for cost control, waste reduction, quality, OSHA, safety, and complete and on-time delivery at the lowest possible cost. ·Balance work cell capacity/loading across the plant. ·Work with Director of Operations to determine operation head count needs and ensures compliance with company policies. ·Work with Director of Operations to identify, communicate and drive implementation of capital investments and improvement projects. ·Manage compliance with state and federal regulations.


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Hire our best Co-Writers in Anaheim, US
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"Tesseract" Album coming at the speed of light but we still a couple light years away... The prelude is reaching our solar system any day now! "Parrallel Universe (Four-dimensional space prelude)" Album out soon for free download on Soundcloud, Datpiff, and Spotify. In modern physics, space and time are unified in a four-dimensional Minkowski continuum called spacetime, whose metric treats the time dimension differently from the three spatial dimensions... The "Tesseract" Trilogy Album Series will consist of three spatial dimension style track listings...Album #1 "Parrallel Universe (Four-dimensional space prelude)"
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Warning: By law we cannot sell this product to anyone under 18, by placing an order with us you are confirming that you are over the age of 18.
Beaphar Banana Nibbly Bitz For Small Animals 50g
99p £19.80 per kg
This is a specialist veterinary product. We will ask you a simple set of questions to confirm that you are buying the correct medicine for your pet and know how to use it safely
Order by 3pm for Express Courier Delivery Some of the items we sell are a bit too bulky to fit on our delivery vans so we offer our customers Next Day Delivery via courier. Deliveries are made from 8am - 8pm Monday to Saturday and 9am - 5pm on Sundays. Your delivery slot will only be confirmed once your order has been placed.
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Mahindra's newly updated version of its Bolero SUV is all set for launch. The new compact version of the Bolero is named as Bolero+. There are no major changes to the exterior on the updated model. The only change to notice is the decrease in size, as Mahindra wanted it to be a compact SUV.
The Bolero+ gets the 1.5-litre m-Hawk D70 engine, but detuned for better mileage. which is expected to be around 16.5km/l. But Mahindra claims that the new engine is better on the performance front. The engine is coupled to a 5-speed manual gearbox, and Mahindra does not have plans for an AMT option.
Coming to the interior, there is no noticeable change. The existing seats have been improved for better cushioning. There is also no changes in the space offered by this SUV. The Bolero+ is a seven seater and this will be its strong point.
The Bolero+ is expected to be priced in the range of Rs 7.1 – Rs 8.6 lakh (on-road). The new SUV will be benefited from its compact size and the micro-hybrid technology, that has been around for some time now.


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Pirate Latitudes by Micheal Crichton
The story is about Captain Charles Hunter (captain of the Cassandra) and his crew seeking to find treasurer. He was hired by the governor of Jamaica to find the it. James Almont, to lead an expedition to the island fortress of Matanceros islands that is protected by the Spaniards. The setting is way back in 1665 England. getting his crew he had a tough time he had to get very fearless people. because the island fortress of Matanceros is a heavily protected fortress. Highly dangerous to the point that people call it a suicide mission. once he finally got it that's where the story begins.
Captain Charles Hunter had a very long and rough journey getting to the island of Matanceros. doing the usual pirate things with his crew the one thing that was smart of them to do. Was hire a jew since none of them knew if the gold or silver was fake or not. Because none of them knew anything but what they usually do.


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Holmpton Rd
HU19 2QF Withernsea, Great Britain
Golden Sands Holiday Park is a private company categorized underRooming and Boarding Houses and located in Withernsea, N HUMBS, United Kingdom. Companies like Golden Sands Holiday Park usually offer:
Dormitory, Mit Dorm, Dorm, Berkeley Dorm and Coed Dorm.
Drywall construction companies
Products: none
Related products and services: Rooming and Boarding Houses, Rooming And Boarding Houses, Rooming and boarding houses in Withernsea, N HUMBS
Number of page views: 438


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Re: Unity 5.0.1 AA problem
Unanswered Question
User Badges:
Hi I have setup Unity 5.01 for Unified Messaging integrated with Lotus notes 7.0. Unity AA has been setup, when users get into the AA and enter the subscribers DN, the calls are forwarded automatically to their VM, the call does not ring on the subscribers phone. what could be the problem? Please advise how to correct this problem?
I have this problem too.
0 votes


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Fishdom episode 1 Tips and Strategies
By: Playrix
Genre: Puzzle
Video Tips
This video walkthrough demonstrates how to beat episode 1 without any power ups. Uploaded on MoonForgetToFallDown official channel at April 25, 2013.
Still need help to finish Fishdom episode 1?
I will update this post with more tips and tricks, so please bookmark this page and keep on checking in!
If you have any questions, feel free to ask for extra help in the comments section.
Hit like if this helped you!
Visit Fishdom walkthrough page for level videos, tutorials, cheats and more.
Episode 1 Questions
Questions related to episode 1 of Fishdom iPhone game.


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Stories of the homeless who met the pope in Rome
As often happens in life, surprises pop up when they are least expected. These homeless people experienced a taste of this after traveling to Rome to be with Pope Francis for the occasion of the Jubilee of Mercy. They come from 22 countries and would never have imagined that they would be able to visit Rome, and even less, to be so close to the pope. "It is a blessing. I feel peace ... many things." "This is all very special: meeting with the pope, praying with the ope. There are many... sensations, yes, that's it." While they are in difficult situations, they prefer to focus on the present moment and their encounter with the pope. "Difficult situation." "Extremely... The situation is difficult for all of us. But we came here and we're waiting." Pope Francis has always remembered the poor, especially during this year of the Jubilee of Mercy, and his visitors feel the warmth of his words especially now. "Rome is very beautiful, the pope has called us to come here and I am very happy to see the pope." Perhaps this visit will not give them a roof when they return to their countries and their lives, but they say they consider themselves enriched to have had an opportunity that many others only dream of. AQ/MB AA SV -PR Up:AC


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So my lil Cain has been doing the single "hah" laugh with the smile for some time now but no giggling. Well today while I was changing his diaper I started sneezing and he just bust up laughing like crazy! It was the cutest thing ever!
So now when I fake a sneeze he just laughs and laughs and it's the sweetest sound in the world
Any other LO's laughing like maniacs yet?


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CANADA: Toyota secures government funding for hybrid production
Toyota has secured Canadian government funding towards hybrid vehicle production in Canada.
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Accommodations withSee All
Airlie Beach enjoys sub-tropical climate all round the year. The summer months from May to November see average daily temperatures of 27 degrees Celsius and some rainfall. However Airlie Beach experiences relatively less humidity than its surrounding islands. Winter from June to October has temperatures drop to a minimum 16 degrees Celsius with an average of 23 degrees throughout making is cool and comfortable. The weather in Airlie Beach is ideal for most tourist activities any time of the year with cool ocean breezes and warm sunshine.
Explore the best travel planner for your visit to Airlie Beach and create a flawless plan in few simple steps!


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Optimal Control Configuration for Active Control of Structural Vibrationsby Mohamed Abdel-Mooty, Univ of Waterloo, Waterloo, Canada,
John Roorda, Univ of Waterloo, Waterloo, Canada,
Document Type: Proceeding Paper
Part of: Mechanics Computing in 1990's and Beyond
An active tendon control mechanism is used to control the vibrations of a bridge-like structure. A single control force controls three modes of vibrations. Special attention is paid to the interaction between the original structure and the control mechanism. The strong relationship between the control force position and the vibrational modes is studied.
Subject Headings: Vibration | Dynamic structural analysis | Hydraulic structures | Active control | Control systems | Dynamic models | Structural dynamics
Services: Buy this book/Buy this article
Return to search


text:
Visual Comparison and Contrast: 5 Valuable Tools to Use
Examining the similarities and differences between two or more things is an important element of many presentations.
For example, an entrepreneur pitching her startup's unique selling propositions might compare her product's features and benefits with those of her top competitor.
In a discussion of political candidates, a presenter might evaluate each one's stand on some major issues, to help his audience make an informed decision.
Occasionally you'll see some presenter make such a "compare-and-contrast" presentation using only textual slides – the two elements being compared are just written out on a slide or slides, connected by "versus" or "as compared to" or some other comparative word or phrase. While this is probably better than nothing, you can use visual elements to make far faster, easier-to-grasp comparisons. Here are a few of the most common:
Venn Diagram
Venn Diagrams consist of two or more interconnected shapes (usually circles) that show relationships between or among the people, groups, or other items being compared. Intersections between two circles indicate factors both have in common.
Charts and Graphs
Graphs and charts work well for comparing quantitative information. The right type of graph to choose depends on what you're trying to show. Are you comparing changes over a specific period? Use column, bar, or line charts. Do you want to compare component of a whole? Consider using a pie, area or waterfall chart. For plotting the distribution of date, look to scatter plot, line, or bar charts.
Head to Jami Oetting's Data Visualization 101 for an in-depth explanation of different types of charts and graphs for data analysis and presentation.
Another type of graphic representation is the continuum: a line with two contrasting factors at its opposite ends. Between these points are stages arranged in a progressive sequence. A continuum is best suited for showing a gradual transition between two extremes. Below you can see an example – a continuum of leadership behavior taken from one of our slide decks in the Themed Slides category. For more examples, check out DoItNow.com's range of alcohol consumption behavior, and TheQuietWisdom's personality continuum scale.
Tables and Matrices
A table or matrix is another effective tool for differentiating two or more items. Many websites use this graphic organizer to compare membership plans, service inclusions, and product features. To build a table, you first determine the items to be compared, decide on the features or attributes you wish to include, and then fill in the table's cells with the appropriate information.
Want to go beyond the traditional diagrams and graphs we've covered so far? Consider building an infographic! They have become increasingly popular over the past few years, and with good reason – they combine visual appeal and interesting morsels of information, drawing the viewer in to explore the subject. A cleverly constructed infographic can quickly and clearly make a point in a memorable way, with a minimum of text. Below you can see a couple of excellent examples.
More Comparison Slides
Our Comparison Slide Deck features a variety of templates to help you make your comparisons more vivid, more clear, and easier to grasp. Your audiences will thank you – and compare your presentations favorably with others they've seen.


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driven by the PitchBook Platform
August 26, 2010
Nautic Partners and Norwest Equity Partners have entered into a definitive agreement to sell Gaymar Industries to Stryker (NYSE: SYK) for $150 million in cash. The company manufactures medical devices for temperature and pressure ulcer management, and its products are currently being sold by Stryker to acute care customers in North America as part of an existing 10-year OEM relationship. Nautic and Norwest acquired Gaymar in a 2003 LBO from Cortec Group.
The recent financial crisis disrupted not only private equity investment, leaving the PE industry with a large capital overhang, but also the exit markets, creating a large overhang of overly mature investments in PE portfolios. For example, private equity investors made 1,203 investments in 2003, and 283 of those investments remain in those private equity firms' portfolios today, according to the PitchBook Platform. In aggregate, those 283 investments totaled well over $15 billion at the time of investment. This overhang of aging portfolio investments will continue to be a significant challenge to PE firms, especially with the challenging exit market today.
August 14, 2017
August 10, 2017
+1 (206) 623.1986
901 Fifth Avenue
Suite 1200
Seattle, WA 98164
+44 (0)207.190.9809
1 Oliver's Yard
55-71 City Road
London EC1Y 1HQ
United Kingdom
+1 (206) 623.1986
155 Fifth Avenue
Suite 500
New York, NY 10010
© 2017 PitchBook Data. All rights reserved. Venture capital, private equity and M&A data and technology provider.


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Today's Featured Artist: Michael Godard
Transform your photos into one-of-a-kind, hand painted masterpieces!
Who Me by Laurilee Taylor - 10" x 8"
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Crackers the Quaker is always inquisitive, and he always wants to put in his two cents worth. 'Who? Me? ... What you talking about? .. That's Ridiculous!!' ( this is a direct quote!)
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