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Title: Work-Life Balance
Author: nancybrown
Rating: PG
Characters/Pairings: Jack/Ianto/Lisa, Team
Spoilers: up through CoE
Disclaimer: So not mine. Really.
Warnings: Deeply fluffy.
Words: 2000
Summary: Whoever said "Home is where the heart is" never had to juggle three adults and three kids in a two-bedroom rental in Caerau. Part of the Rabbit Hole AU.
A/N: Originally posted at Share and Share Alike for the "Three Weeks for Dreamwidth" project. (Prompt 18.)
Lisa's mobile rang. Cursing, she turned it off without even looking at the ID. Anyone who was important had his or her own ringtone; this call had been the generic ring. She turned her attention back to the readings on her scanner. "Power fluctuations are getting stronger. We're running out of time."
Two minutes, a flurry of motion, and a large number of bullets fired later, the Gr'nak who'd come through the Rift planning world domination was dead. Johnson holstered her weapon while Gwen made the call back to the Hub to let them know it'd been taken care of. Lisa didn't correct the premature celebration, but instead went to work on the Gr'nak's energy device, unfastening the cover and following Tosh's instructions in her ear on how to safely disarm it.
As she pulled wires carefully, Tosh said, "This isn't the first Gr'nak to try this plan."
"Good thing for us they only have the one plan, then." Behind her, Gwen and Johnson hefted the body into the back of the SUV. Crazily, Lisa had an annoying song from one of her daughter's favourite programmes running through her head: "What's gonna work? Teamwork! What's gonna work? Teamwork!" Parenthood rotted your brain from within, she decided, and pulled the last wire. The energy device failed to destroy south Wales.
When they were in the car headed back, Lisa remembered to check her voice mail.
"Hello, Mrs. Jones!" piped a perky voice. "This is Anita from Frost Lynch. I've got a list of homes ready for you and Mr. Jones to view. I've left messages at the other number you gave me," she added, with the perkiness dropping a little. "If you could call me back, I'd appreciate it!" She gave a number, which Lisa knew they already had on a magnet on the refrigerator with Anita's smiling picture printed on it.
She closed her phone.
"Everything all right?" Gwen asked.
"Fine. Bloody estate agent."
"Oh. How's the house search going?" Gwen was good at offering openings: not exactly prying, but allowing other people to overshare. It was how they'd met, months back.
"It's going fine. We just haven't had much time to look."
"I know what you mean. Rhys practically had to choose our house by himself."
Johnson, as usual, had nothing to add to the conversation. Lisa met her eyes briefly in the mirror, but found no emotion she could name. Lisa kept wanting to find common ground with the other woman besides matters directly related to work. However, an opening conversational gambit of, "So how do you feel about the fact that I'm sleeping with your girlfriend's father?" was simply not going to lead anywhere constructive, no matter what Gwen said.
Back at the Hub, Gwen handed the keys to the SUV to Ianto with a pat. Lisa offered him a quick kiss. "We have to talk about the house tonight."
He nodded, took the keys, and went to deal with the body in the car. She watched him go. One of the problems with working with one's spouse was trying to negotiate the boundaries between work and home. They'd been co-workers before they'd been lovers, and stayed co-workers after they'd married, and she thought on the whole that they'd managed a stable balance.
The outer door opened again as Ianto reached it, and Jack swept in with Andy and Mickey in tow. "Hope Street," he announced happily. "Now with two fewer Weevils." He handed Ianto the keys to that vehicle and gave him a quick kiss of his own.
"At work," said Mickey in a less than patient voice.
"Going," said Ianto, two sets of car keys in his hand and a flush creeping over his collar.
Lisa sighed, checked on the baby, then walked back to the lab she shared with Toshiko to thank her for the help. Balance was something that was much harder to achieve when one and one's spouse were dating the boss. Jack gave them orders every day, orders that could easily lead to their deaths if it meant saving the Earth. Some days she had trouble parsing that man as separate from the one who was not technically living with them but came to their bed almost every night and made breakfast for the children in the morning.
Ianto lost the coin toss to leave work on time. While Torchwood never worked to the clock, the agreement was that unless the world was in deadly peril, someone left to fetch the children from Rhiannon's place and feed them supper at home. Seeing as it was Lisa's turn, that probably meant spaghetti hoops for the older two. Jack didn't take many turns staying home with the kids when work called, especially late at night, but then, Jack rigged the coin tosses and thought neither of them had noticed yet. It was both exasperating and charming.
When the last proverbial fire had been extinguished -- a Melorian raider and her crew in a near-collision event, fortunately avoided -- Jack shooed out the rest of the staff, set the alerts to automatic, and then waved his own car keys at Ianto. "Need a lift?"
There was always that second question in the air. While Jack seemed to enjoy his time with them at the little house they were renting, and while he thought nothing of showing up uninvited, it was always with the quietest note of fear. Part of him expected to be told to go. The staff therapist wasn't permitted to disclose anyone's individual details, but Ianto knew that if he had access to Jack's file, the words "Abandonment Complex" would be written in red at the top. The manifestations of same were also exasperating and charming.
"I thought you'd never ask." And there was the relief, flickered past the bravado and gone again.
They didn't talk much on the ride home. The perils of living with someone one also worked with included a much tighter list of safe topics for small talk. For example, Ianto couldn't blow off steam about his idiot boss or inept co-workers, and neither could Lisa, while Jack was no doubt dying inside to have just one person to complain to that he could have hired trained marmosets to do a better job some days.
This, Ianto mused, was why people had friends outside of work.
Back at the house, Lisa was putting the kids to bed after their baths, so Ianto tidied while Jack fixed the adults something to eat that wasn't out of a can. They tried, and failed to avoid bumping into one another as they went about their tasks, but the space had been small with the five of them, and adding another adult to the one storey house hadn't helped. Whoever said "Home is where the heart is" never had to juggle three adults and three kids in a two-bedroom rental in Caerau.
At last, they settled at the table with plates of something that looked like chicken and noodles, and smelled like garlic and butter. Ianto heard scuffling from the bedroom Callie and Kyle shared. Lisa saw his face and said, "I told them they could play quietly for a little while. You can both go in for kisses after dinner and tell them it's time to sleep."
Ianto didn't miss the slight emphasis on "both," and neither had Jack. He saw Jack smile around a bite of noodles.
Lisa said, "I heard from the estate agent today. She says she's found us some houses to look at."
Ianto groaned. "Can we make time on the weekend to look?" He glanced at Jack.
"Put it on the calendar. Lois can schedule you around a few meetings during the week if that's what you need to do."
"The Rift doesn't pause for house hunting," Ianto said.
"No, but if we know we're going to be down two people for an hour or two, we can work around it if something comes up. When Gwen was buying a house, she was called away all the time." Jack went to smile but it got caught in a memory somewhere and left him again. Ianto did the math and figured that Gwen would have been buying her house around the same time that everything went very badly for Jack. There was no good way to offer comfort to someone who'd survived horrors that had later been rewritten, although Martha seemed to understand.
Lisa said, "We should call Anita tomorrow. We have to tell her our specifications have changed."
"Hm?" Close to good schools, close to work, reasonable price range, probably a three bedroom and the girls would share when Isabelle was out of her cot. It'd be … "Oh."
"We'll be looking in the same neighbourhoods," Lisa said, "and I'm sure she'll be able to find something."
"It's going to raise the prices we're looking at."
Lisa shrugged. "It's only money." She looked at Jack. "One of us will meet with the agent to look when she's got a list. After we've narrowed it down, we'll plan an afternoon or a weekend, something when the Rift predictor says it's going to be quiet, and make a decision."
Jack nodded. "Just let me know when you'll want the time off."
Lisa look to Ianto for help. Ianto looked back, with no idea of what she wanted him to do. More precisely, he did know, but had no idea of how to say it.
Finally Lisa said, "Fine. I'll see if Lois can clear your schedule."
"If Lois can … " Comprehension dawned. "That'd be helpful. Thanks." Ianto wasn't sure if he should read the somewhat dazed expression as happy or worried. The problem with Jack's abandonment issues was that he often took them as a reason to be the one to leave first, at least according to rumour.
He said, "Tell the agent we want five bedrooms. My sister is only going to believe Jack is sleeping on the sofa so long." Poor Jack, going through a divorce and needing to rely on the charity of friends, and so far, both extended families bought it.
Lisa found a slip of paper and began to write. "I'll want an office as well. We can turn the fifth bedroom into that, but I'd rather have a study or similar to use. What about the kitchen?" This she asked of Jack, pencil at the paper. "Any requests?"
"Counter space," said Jack. "Anything else can be bought later." His eyes locked on her hand as she wrote it on her list.
Ianto said, "A basement or a decent attic for storage."
Lisa wrote "storage," then said, "A real dining room."
"We should look at new furniture," Jack said, and Ianto only heard the catch on the "we" because he'd been listening for it. "If we're going to have a dining room, we're going to need a better table than this one." Lisa made notes on the other side of the paper. The noise from the children's room had ceased. They'd have to sneak in for goodnight kisses.
She said, "We'll have to purchase a washer and dryer. The kids are dirtying two and three outfits every day."
Ianto nodded. He took their work clothes to the dry cleaner, but the piles of tiny clothes in the children's room were reaching scary proportions as the adults tried and failed to find time to do something about it. He'd been a stay-at-home father for a reason. But Torchwood had beckoned, and Jack had given him the look that said he already knew what Ianto was going to do before he did it, and "No" was no longer an option.
He summoned up that look now, and turned it onto Jack. The dazed expression faded, to be replaced by a familiar, rakish grin as Ianto said, "Tell Anita to make certain the master bedroom is large. We're going to buy a bigger bed." He stopped himself from commenting how none of them were small; Lisa was still sensitive about not having lost the last of the baby weight yet.
She smiled as she wrote down, "Bed. Big."
Jack sat back in his chair, limbs in a happy sprawl. "You're right. And that's going to require a lot of comparison shopping. We'll need to clear, oh, at least three days on the schedule as soon as possible."
Ianto said in his most professional voice, "I'll inform Lois in the morning."
Lisa set aside the paper. "I can give this list to Anita tomorrow. Are we done?"
Ianto shrugged and Jack said, "I suppose we are."
"Good." She stood up and grabbed a hand from each of them. "If we're going to replace the bed, we should at least give the old one a good send-off."
The End


text:
Keep in mind, I am not asking this in search of attention. Nor do I lack confidence in my appearance. I am just curious. (: Thanks.
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subset: commoncrawl


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Rick Ament
Veteran Health Care Executive in Michigan
About Rick Ament
A veteran health care executive, Rick Ament brings more than three decades of experience to his current position as the president and CEO of Beacon Healthcare Finance. Based in Green Bay, Wisconsin, Beacon Healthcare Finance is the product of combining Beacon Leadership Group with Beacon Commercial Finance. Beacon Leadership Group is a boutique healthcare consulting firm and Beacon Commercial Finance is a full service capital finance company.
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State workers sweep Grand Forks blood drive
State employees in Grand Forks County brought the heat -- and blood -- in an annual blood donation competition held Thursday in the Grand Forks County Building.
State workers donated head to head against county and city workers in the Holiday Blood Drive Challenge. As the drive wound down, almost 30 state employees had donated blood while the county and city followed at 14 and six donors respectively.
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This drive is the blood bank's last big push for December, a time Jensen considers the season of giving.
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The holiday drive will help carry the facility through to January, which is National Blood Donor Month and the month when Dak Minn gets some of its biggest donations.
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CHAMBERSBURG, Pa. -- Marlin D. Zook, 68, of Chambersburg, Pa., passed away on Wednesday, March 15, 2017, at Chambersburg Hospital.
Born March 15, 1949 in Youngstown, he was the son of the late David M. and Edna Weaver Zook, and the stepson of the late Emma Zook. A 1967 graduate of the North Lima High School, Marlin went on to attend Hesston College in Hesston, Kans.
A licensed insurance agent, he owned/operated the Marlin Zook Agency in Dalton, retiring in 2013. He was a member of Brookview Chapel at Menno Haven and was a lifelong supporter of Pregnancy Care Ministries in Wooster and in Chambersburg, Pa.
He enjoyed teaching Sunday school, was an avid gardener, and had a lifelong love of ping pong, airplanes, trains and flying. He was a licensed pilot in his younger years.
Surviving are his loving wife of 44 years, Rose Police Zook, whom he married May 14, 1972; his sons, Daniel Zook and wife, Jacinda of Dalton and Jeremiah Zook and wife, Melanie of Chambersburg, Pa.; grandchildren, Verda Rose, Patrick, Jeren, Vincent, and Selena; and siblings, Rhoda McClain and husband, Dale of Columbiana, Mary Louise Uchida and husband, Mel of Laupahoehoe, Hawaii and Herb Zook and wife, Marlene of Belleville, Pa.
Services and interment will be private.
Memorial contributions may be made to Pregnancy Care Ministries of Wayne County, 142 W. Liberty St., Suite 3a, Wooster 44691; or Wycliffe Bible Translators in support of Ken and Mae Zook, P.O. Box 628200, Orlando, Fla. 32862-8200.
Arrangements are entrusted to Thomas L. Geisel Funeral Home & Cremation Center, Chambersburg, Pa. Condolences and memories may be shared on his Book of Memories page at www.geiselfuneralhome.com.


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Prices, specials, features and availability subject to change.
Beautiful and quiet North Phoenix setting. Create your own living space at Belara, Now Leasing!!!!. Belara features an abundance of floorplans that you can make your own. Choose from 1 or 2 bedrooms that feature a variety of options: breakfast bar or kitchen island; corner balcony or covered terrace, attached or detached garage. Whatever your lifestyle, there is certain to be a design that fits your needs. You can even select a custom accent wall and further personalize your living space. Outside, your choices continue: would you like to meet friends at Belara's outdoor fireside lounge or in the chic clubroom? Work out at the fitness center? Finish that last report at the business center or on your laptop by the pool? Stay at home or hit The Shops at Norterra?
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307 units
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Great location and staff. Very well maintained.
April 16, 2017
Thank you for the five star review! We are so happy you are enjoying your home with us.
The adult atmosphere
April 15, 2017
Thank you for taking the time to review our community, we are pleased to see you gave us a five star rating! We appreciate you and hope you enjoy Belara for years to come.
The staff is very friendly and helpful.
April 14, 2017
Thank you for taking the time to review our community, We strive for "5"!
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Quiet and clean
April 14, 2017
Thank you for taking a moment to complete this for our team and community... We are so happy you are enjoying our five star service. We are always here for you seven days a week if you ever have any questions or concerns.
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The facilities and symphatic staff
April 14, 2017
Thank you taking the time to review our community and team here at Belara. We hope you continue to enjoy your stay with us!
Monday-Tuesday: 10:00am-6:00pm
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is there anyway, i have a xp machine a windows 2000 Virtual on it, i have ran a few different Avs across it but have not found anything, yet i know the last time ti was connected to teh network, 60 accounts locked almost immediately. we use trend and our version will not work on win 2k, when I scan the files on teh Physical machine, will do locate any issues, or is there a way to mount the drive like i would a secondary physical drive and scan it that way?
Oct 19, 2011 at 4:33 UTC
Here's how you can install VHDMount :)
This will make mounting / dismounting easy once VHDMount is installed
8 Replies
Oct 19, 2011 at 3:41 UTC
For clarification, are you wanting to mount this as you would, say, an ISO image for direct file access?
Oct 19, 2011 at 3:48 UTC
To mount a .vhd as a drive letter with Virtual Server installed
Oct 19, 2011 at 4:24 UTC
say i have my desk top and a user brings me teh HDD out of their physical machine, i can take that drive, hook it up to my desk top with what ever connection type i need to sata, esata, IDE, USB adapter, so on. I can then right click that drive and scan it with my AV. is there a way to do this with a VHD?
Oct 19, 2011 at 4:29 UTC
You can use the VHDMount utility to mount a .vhd file as an additional drive letter.
Are you using Virtual Server to run your VM?
Oct 19, 2011 at 4:31 UTC
this particular machine is using virtual PC 7
Oct 19, 2011 at 4:33 UTC
Here's how you can install VHDMount :)
This will make mounting / dismounting easy once VHDMount is installed
Oct 19, 2011 at 4:39 UTC
perfect, thank you all so much
Oct 19, 2011 at 4:39 UTC
all??? lol thank you so much
This discussion has been inactive for over a year.
You may get a better answer to your question by starting a new discussion.


text:
Like a mirror, art reflects the beauty of the world around us, reveals who we truly are, and can contain a lot of naked people. Step into a funhouse of art-mirrors with today's Groupon to the Museum of Fine Arts in St. Petersburg. Choose between the following options:
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- For $16, you get two adult admissions (a $32 value).
The hallowed halls of this prestigious museum permanently house works by Claude Monet, Georgia O'Keeffe, Robert Henri, and Aaron Siskind, among other hard-boiled image capturers. Its original building, designed by John Volk, opened in 1965 and has since expanded to include two interior gardens and the MFA Café, which allows eyes to continue their feasting frenzy with views of the downtown waterfront. More than 10,000 images take up two-dimensional residence on the MFA's walls, and ancient Greek and Roman sculptures prance boastfully around its galleries, having conquered the dimension linking time and space. In addition to the museum's permanent collection, rotating exhibitions ensure that return trips, like your last three identities, are warranted.
Frommer's, the St. Petersburg Times, and Art Daily have all featured the Museum of Fine Arts. Three TripAdvisors give it an average of four owl eyes:
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Museum of Fine Arts
The Experience
Inside a building in St. Petersburg, works of art from around the world gather like good friends. Georgia O'Keeffe's Poppy hangs not far from Paul Cézanne's A Corner of the Woods, Pointoise. Claude Monet's Houses of Parliament gives a glimpse of faraway lands, while Thomas Moran's Florida Landscape stays closer to home.
With a range of permanent and rotating exhibitions, the Museum of Fine Arts seeks to engage visitors with art while preserving the pieces in its care. Much of the collection resides in an original 1960s building, but the adjacent modern gallery area draws in visitors with special exhibitions, interactive educational facilities for children, as well as being a beautiful location to hold a corporate dinner, wedding reception, or event. Guests can also stroll into the museum store to browse unique gifts, artisan jewelry, books, and more.
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- Nine rotating exhibitions are scheduled for the coming year, with member receptions in advance of each public opening.
Who They Are
The MFA serves over 100,000 visitors annually ranging in age from young children to adults. The Museum is dedicated to engaging and adapting to the community at large. In addition to the wide selection of art from past time periods through modern day, the Museum of Fine Arts offers educational workshops and two gardens where visitors can browse and relax.


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- Yes I do59%(26)54%(50)Vote50%(24)
- No I do not41%(18)46%(42)Vote50%(24)
Most Helpful Girl
I've been a paranormal investigator for 7 years, and I've experienced some shit that terrified me, because I couldn't explain it. I don't think demons are exclusive to the Christian pantheon, more that those beings fall under the "demon" classification. They take many forms, have many different abilities, and not all of them are "evil", in my opinion.00|00|0
I hope you don't mind my asking, but how do you even get into something like that? Do you break into the house and investigate for your own knowledge, or do you work for some company that gets hired to give a family peace of mind, or something else. The only people I have ever met that did that, all claimed they broke into the houses, so I was wondering how it actually works.
- Show AllShow Less
I don't even know what a Demonoligist is. The tour thing sounds fun though. All I have been able to find are bread and breakfasts that claim to be haunted in order to pull in more guests.
@heavensgift2girls A demonologist is someone trained by the Catholic church in exorcism and purification of homes and other buildings. Yeah, we have a lot of haunted B&B and restaurants here too, but the city requires that they provide proof of their claims in the form of historical evidence of deaths on the property, and at least 10 credible accounts from separate sources of haunting activity.
Most Helpful Guy
Maybe. Though if they are, I seriously doubt that they are as dangerous as "The Exorcist" would lead you to believe. Most of the early Christian literature on them such as "The Sayings of the Desert Fathers" among other ascetic writings describe them as tricksters, more of a nuisance than anything else whose sole aim is to distract your attention away from God. I believe this is how the Qur'an also describes the jinn? In either case, the Philakolia famously advises monks to not look up into the sky while praying, lest demons distract them.00|00|0


text: But not now. Not with the papers reading the way they are. So the financial buyers are dumping Brent at the exact same time that the actual producers in the United States are getting their product to the world market instead of having it landlocked in the Midwest. The result? The world price is coming down. Now, of course, unlike all of the other markets there is a swing producer here in Saudi Arabia. The Saudis may not know about all of the oil discovered here or can't game it because we do not have a government with an energy policy, so you don't know what will be used -- Canada tar sands -- and what will forever be locked into the ground because of the lowered price. But they know Iraq is starting to pump much more than it used to and that Libya is back on line. They know that the big Nigeria-to-U.S. oil trade isn't slowing. Neither is the Algeria trade. So it is possible that they cut back and make the market tight again. Remember the tug of war there. They must keep the price tight enough to maximize profit without encouraging more drilling or conservation. If they pull back then the financial buyers have nothing to fear. But if they don't, then oil will be in the same free fall that all of the other commodities that have been propped up by the China marginal buyer trade. So, the financial buyers are being margined out, globally, or they are giving up on the trade and what you are seeing is an unprecedented rollback in prices on everything raw. Oh, one more thing. Don't forget that it is good for all but a handful of companies that actually produce iron, aluminum, nickel, copper, oil and the like. It's just not good enough right now for people to realize it. Action Alerts PLUS, which Cramer co-manages as a charitable trust, has no positions in the stocks mentioned.


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Disclosure of Material Connection: I received one or more of the products or services mentioned above for free in the hope that I would mention it on my blog. Regardless, I only recommend products or services I use personally and believe will be good for my readers. I am disclosing this in accordance with the Federal Trade Commission's 16 CFR, Part 255: "Guides Concerning the Use of Endorsements and Testimonials in Advertising."
**This post contains affiliate links**
It's important for kitchen safety to have a sharp knife.
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Question: As a class decide on a fictional large scale change
As a class, decide on a fictional large scale change that could affect Dupont. Divide the class into three groups (and role-play the situation in two acts). In Act 1, one group will take a problem solving approach and introduce the change with the second group (Dupont staff affected by the change). In Act 2 a third group (the appreciative inquiry group) will introduce the change with the second group (Dupont staff affected by the change). After the exercise, compare and contrast the steps taken in each approach. From the point of view of group two (Dupont staff), which approach seemed to work best? Why? From the point of view of groups one and two, how easy/difficult was it adopting this approach? What broad conclusions can be drawn?
View Solution:
View Solution:
Answer to relevant QuestionsHow many people would it make sense to involve? Review the swipe card story, drawing on each of the following change perspectives discussed in Chapters 7 and 8: • Organization development • Sense-making • Change management • Contingency • Processual From ...To what extent were these successful? Using what criteria? How influential do you think such articles are on the managers who read them? Describe how the turnaround team may have used Gerard and Teurfs' transformation skills to overcome the frustrations of employees.
Post your question


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Talk:Roger Temam
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Most thesis supervised by an individual at this school, in the US, in the world? The category says but this is an American professor.--Wadeperson (talk) 18:22, 31 December 2008 (UTC)
- Temam worked in both Université Paris-Sud 11] and Indiana University, Bloomington. The highest number of PhD is in the field of mathematics. Salih (talk) 06:42, 3 January 2009 (UTC)
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15 Books to Empower Tween Girls
Learn about good books that will empower young girls, tweens and teens. Shop books for girls on Overstock.com.
The Alchemist by Paulo Coelho continues to change the lives of its readers forever. With more than two million copies sold around the world,The Alchemist has established itself as a modern classic, universally admired.
Paulo Coelhos masterpiece tells the magical story of Santiago, an Andalusian shepherd boy who yearns to travel in search of a worldly treasure as extravagant as any ever found.
The story of the treasures Santiago finds along the way teaches us, as only a few stories can, about the essential wisdom of listening to our hearts, learning to read the omens strewn along lifes path, and, above all, following our dreams.
Acclaimed illustrator Daniel Sampere brings Paulo Coelho's classic to new life in this gorgeously illustrated graphic novel adaptation.
|COMICS & GRAPHIC NOVELS / Fantasy
|Publisher Date
|2010-11-23 00:00:00.0
|Copyright Year
|9.25 in
|5.75 in
|0.75 in
|Unit weight
|1.1 lb
|Coelho, Paulo
|Country of Origin
|United States
Shipped quickly, it's cool if you're really into comic books but I enjoy reading the original version more. I feel as if the graphic novel is missing something the original copy offers.Read More
Learn about good books that will empower young girls, tweens and teens. Shop books for girls on Overstock.com.
Best Books to Give for Mother's Day from Overstock.com. If your mom is a bookworm, use these tips to find her a literary Mother's Day gift.
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best SD ammo for 9mm
I just got my CC permit and am new to the SD ammo scene. Obviously big names like hornady stick out but what are some good quality brands for low quality price? I don't want to skimp on things that could save my life but I'm realistic in the amount of money in my budget.
1 Attachment(s)
Winchester PDX1 124gr +p are good, just switched from Federal Hydra-shoks 124gr.
Attachment 67160
The picture isn't great, but Federal on the left, PDX1 on the right. Approximately 1/4" hole vs 1/2" hole! PDX1 is a much nastier round, and costs about $5-$6 less per box.
most any of the name brand SD should work just fine. personally i would go for what functions perfectly in my pistol vs. what is the most super dooper, and, best and newest expanding ammo available. doesn't mean a lot if the ammo won't function reliabily in your firearm.
I've been practicing with fmj Winchester white box. Should I still practice with maybe 50 rounds of the SD ammo to make sure it runs thru my pistol?
I use Hornady Zombie ammo. Its the same exact thing as their critical defense stuff, but a few bucks cheaper. As far as cycling in your gun, i have tested it in 4 different guns (Ruger SR9C, Springfield XD, Smith and Wesson M&P and a Glock) and i have never had an issue. I usually test with 5 or so rounds. Since the Hornady Critical Defense / Zombie ammo comes with 25 rounds in a box, this leaves you with 20 rounds to load with. 5 rounds usually gives you a good feel for a round's ability to cycle in your gun.
A lot depends on the type of 9mm you are using. Smaller barrels create different ballistics on the 9mm round. If you are using a smaller barrel, the Speer gold dot 124gr jhp has shown some good test results. If you are carrying a longer barrel the federal hydro shocks 124 gr, as mentioned earlier look good too. Try a Internet search for ballistics and type in the length of your barrel or weapon make and caliber. Here is a start:
We have 9,000 posts about 9mm ammo. why start another?
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|Drugs and Magic Remedies (Objectionable Advertisements) Act, 1954
|Sections 3, 4 , 5 and 7
|Sections 3, 4 , 5 and 7
Complainants claiming herself to be "Divine Mother" having supernatural powers for curing many diseases and also had in a Television Talk claimed of curing cancer patients - offence if any committed? - Held it is sufficiently clear that in the alleged advertisement in news papers there is no indication of use of any Drug for the purposes as enumerated under Section 3 of the Act. It is simply indicated in the advertisement that the problems enumerated therein can suprisingly be solved. Such advertisement is published under the heading "Jyotish" (means Astrology) indicating that it would be supernatural or spiritual or astrological solution. Spiritual, supernatural or astrological activities are not prohibited in this country, nor taking avocation of Astrologer is an offence and accordingly, publication of advertisement of Astrology or of an Astrologer cannot be construed to be an offence under the Drugs and Magic Remedies (Objectionable Advertisement) Act, 1954 or under any of the statute - publication of an advertisement in the manner done in this case cannot be construed to be an offence punishable under Section 7 of the Act - it is a conviction of the complaint that cancer cannot be cured by Stones or Metallic substance as because this is a clinic disease, as has been opined by the Cancer Experts. On the other hand, the appellant opined in the Televisions discussion that cancer patients could be cured by spiritual or supernatural power. but mere opinion on a questionable topic cannot be construed to be an offence punishable under Section 7 of the Act. However, in the alleged advertisement in the Newspapers it was never claimed that cancer can be cured by Magic Remedy.
Prabir Ghosh vs. Smt. Jaya Ganguly and another, CALCUTTA HIGH COURT, 2003 Drugs Cases 125
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text:
How did the Galaxy deal with Major League Soccer's roster-compliance deadline? They didn't.
The club made no moves, and didn't have to, to come in under the $2.81 million salary cap on a roster of not more than 30 players, giving themselves another week, even longer, to make decisions on draft choices and the final trialist in camp.
L.A. has 28 players on their official roster, of which 18 to 20, depending on designation, count against the cap. The club has not divulged how it has divided players within the roster, and it is uncertain whether it will do so.
Five non-roster players, four of them selections from in January's SuperDraft and supplemental draft, remain in camp, battling for positions on the team. Injured defender Omar Gonzalez won't count against the roster while he is on the Disabled List, at least until September, so there is room for three additions and plenty of time to make moves.
"We think we've got a handle on it," assistant coach Dave Sarachan told ESPN Los Angeles a few hours before the 2 p.m. PT compliance deadline. "There is some decision-making still taking place. It's not a rubber-stamping thing. With some of the trialists, draft picks, they've made it hard on us, and that's a good thing. There's still a couple decisions that need to come."
Those decisions, he said, would come "more likely after this weekend."
The Galaxy opens the season Wednesday night in Toronto, in a CONCACAF Champions League quarterfinal first leg. They'll play their league opener March 10 against Real Salt Lake at Home Depot Center.
The roster-freeze date is in mid-September, but players can't participate in competitive games -- MLS Reserve League excepted -- until they are under contract.
FRONT-OFFICE MOVES: Chris McGowan's appointment as chief operations officer of the Galaxy and the dismissals of three club officials is part of a realignment within AEG, which has formed AEG Sports to the company's many sporting enterprises, according to sources within AEG and the Galaxy. McGowan, 38, also the L.A. Kings' COO, will head the new division and report to AEG President Tim Leiweke.
AEG has not officially announced the realignment but has revealed McGowan's appointment.
President of business operations Tom Payne, communications director Patrick Donnelly and marketing director Veronica Avila have left the club, and more departures are possible. Leiweke told Sports Business Daily that McGowan's top priority was to "dramatically" improve Galaxy ticket sales. "This is all about season-ticket sales for the Galaxy," he said. L.A. has sold about 7,500 season tickets this season, Leiweke told the publication, far below the clubs in Seattle, Portland and Toronto.
Former Galaxy midfielder Chris Klein, who heads the club's academy, is taking on added business responsibilities within the realignment.
WORTH NOTING: Robbie Keane will arrive in Southern California by the weekend and join up with his teammates before departing Monday for Toronto and next week's Champions League quarterfinal. … Landon Donovan, recovering from bronchitis, is "pretty close" to getting back on the field, Sarachan said. Might he play in Saturday's Desert Diamond Cup final against New England in Tucson? "We haven't made that decision." ... Injured defender Sean Alvarado's contract was not renewed. … New York coach Hans Backe said goalkeeper Ryan Meara suffered a broken nose in Wednesday night's Desert Diamond Cup clash against L.A.
ROSTER LIST: Here's the roster the Galaxy submitted to MLS:
Bill Gaudette
Brian Perk (Rancho Santa Margarita/UCLA)
Josh Saunders (Lake Forest)
Andrew Boyens (New Zealand)
A.J. DeLaGarza
Todd Dunivant
Sean Franklin (Palmdale/Cal State Northridge)
Omar Gonzalez (DL)
Bryan Jordan (Temple City)
Leonardo (Brazil)
Tommy Meyer (R/draft)
David Beckham (DP, England)
Paolo Cardozo (Argentina), on loan from Quilmes (Argentina)
Landon Donovan (DP, Redlands)
Hector Jimenez (Bell Gardens)
Juninho (Brazil), on loan from São Paulo (Brazil)
Dan Keat (New Zealand)
Mike Magee
Kyle Nakazawa (Palos Verdes Estates/UCLA)
Marcelo Sarvas (Costa Rica)
Michael Stephens (UCLA)
Jose Villarreal (R, HGP/Inglewood)
Chad Barrett (UCLA)
Edson Buddle
Adam Cristman
Robbie Keane (DP, Ireland)
Jack McBean (HGP, Newport Beach)
Pat Noonan
D Justin Davies (R/draft)
M Rafael Garcia (R/draft, Canoga Park/Cal State Northridge)
D/F Bryan Gaul (R/draft)
D J.T. Murray (R/trial)
M Kenney Walker (R/draft)
DL -- Disabled List
DP -- Designated Player
HGP -- Home Grown Player
R -- Rookie
Note: Local hometowns/colleges and/or foreign designations in parentheses


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My husband and I were traveling back from a wonderful vacation in Myrtle Beach and decided to stay overnight. We were looking on trip advisor for places to stay and stumbled upon Cripple Creek Cabins. The cabin was a pleasant surprise and a nice end to our vacation. It was beautiful and the location was away from everything. We spent a quiet and relaxing evening, and wish we could have stayed longer. We were surprised that the owner included a wonderful breakfast delivered to your door. If you ever get the chance to spend a few days with no interruptions, I highly recommend these cabins!
- Official Description (provided by the hotel):
- Secluded individual cabins designed for a romantic getaway or just a quiet relaxing evening during your travels and we are only 15 minutes from I-77 and I-81. King sized beds, large two person whirlpool tub, wood burning fireplaces all in one room with a home made breakfast delivered to your cabin. Enjoy the rocking chairs on the porch and reconnect with Mother Nature. ... more less
- Also Known As:
- Cripple Creek Bed And Breakfast Cabins Hotel Wytheville
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Amalgamation (fiction)
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Amalgamation or amalgam, when used to refer to a fictional character or place, refers to one that was created by combining, or is perceived to be a combination, of several other previously existing characters or locations. To emphasize the origin of their creations, authors or artists may use amalgamated names.
Amalgamated characters[edit]
|It has been suggested that this section be merged into Composite character. (Discuss) Proposed since October 2015.
An amalgamated character is one that is based on other characters. Amalgamated characters may be a character whose appearance is entirely original to that author or artist, but whose personality shows aspects of several existing people or fictional characters. Such characters may appear to have a split personality, rapidly and inexplicably shifting between how their inspirations would act.
Other amalgamated characters may have their appearance based entirely on existing people or fictional characters. This may go as far as desired by the author or artist, and such a character may even have each eye in a different color. Such characters usually also incorporate some of the personality aspects of their inspirations, or have an entirely original personality.
An author or artist may choose to amalgamate a character, rather than imagining all of its aspects from scratch in order to be humorous by referencing other works and/or real people. This is why such characters are more common in parodies.
- All the characters from Amalgam Comics are combinations of superheroes from Marvel Comics and DC Comics, such as Super-Soldier (Captain America + Superman) and Dark Claw (Wolverine + Batman).
- Disney's version of the Queen of Hearts, as seen in the 1951 adaptation of Alice in Wonderland, seems to be an amalgam of the Duchess and the Queen in the original book, and the Red Queen of Through The Looking-Glass
- The popular web comic Homestuck takes a more literal approach to this, as in Act 6 the bodies of two deceased trolls are combined into one spirit-like entity, called "sprites". Sprites sport equal parts of each troll's physical appearance and personalities, and have names created from the two (for example, the trolls of Eridan and Sollux became Erisolsprite).
- The Crew aboard the Flying Dutchman in the Pirates of the Caribbean and the ship itself appear to have sea-life mutated into them.
- The Amalgamates in the True Lab in Undertale that are reanimated fusions of corpses of previously deceased monsters. They were created by Alphys as experiments.
Amalgamated places[edit]
Places may be amalgamated in fiction by taking districts, landmarks, or characters of existing locations, or previously created locations of another work of fiction. Thus, a sample fictional city could contain the Eiffel Tower a block away from the Forbidden City, where Bill Gates may be living after having bought a nearby clacks tower from Albus Dumbledore. Usually, if the author or artist desires the city to be more believable, he or she will amalgam it only from real places, whereas if the story is more fantastic, fictional places may be better.
An author or artist may choose to amalgamate a city rather than imagining all of its aspects from scratch in order to be humorous by referencing other works and/or real places, or to avoid having to name his or her city altogether, such as when shooting a film in several existing cities, while the city portrayed is supposed not to exist.


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I'm delighted to have had poems in the following magazines and anthologies - big thanks to all the editors!
Poems have appeared in a variety of anthologies and magazines in the UK, Italy and North America, including: Orbis, Tears in the Fence, Obsessed with Pipework, Rain Dog, Envoi, Smoke, Southlight, Seventh Quarry, Poetry Cornwall, Citizen 32, Diamond Twig And Other Poets, The Poetry Shed, Mediterranean Poetry, InterlitQ, Jacket2 and more!
UK anthologies:
Sculpted – Poetry of the North West; Running Before The Wind and The Price of Gold, Greyhen Press; On a Bat's Wing (Five Leaves Press), Simply Connect (Cinnamon Press), Not a Drop – Just Oceans of Poetry; My Dear Watson – The Very Elements in Poetry; Heavenly Bodies – a constellation of poetry Beautiful Dragons Press; The Raspberry and the Rowan (Cumbria Wildlife Trust); The Other Side of Sleep, Arachne Press; Live from Worktown 2014; The Cockermouth Poets, River Press Cockermouth; Watershed, Harestone Press; Both Side of Hadrian's Wall, Selkirk Lapwing Press; Advice on Proposals (Jane Austen), The Scratching of Pens (Brontes)Like This Press;
USA anthologies:
Primal Sanities – A Tribute to Walt Whitman (Allbook Books);
Elegant Rage – A Poetic Tribute to Woody Guthrie; From Maspeth to Montauk and Beyond, The North Sea Poetry Scene Press; Inspire the Planet, IGotMuse.com
Italy: anthology
Hortus Conclusus, Poetry on the Lake, ed. Gabriel Griffin
For Rhino in a Shrinking World, The Poets Printery, ed. Harry Owen
Online magazines I've been published in include:
Ink, Sweat & Tears
And other poems
The Poetry Shed
Peony Moon
The National Trust Project Write on the Gondola
The Skin … there's a freshness about her work that brought tears to my eyes. Real tears, like a child's." – Anne Stevenson, Mslexia OctNovDec 2003
Geraldine Green's passion for and knowledge of the natural world and its spiritual energies has its roots and takes its cue from home ground, her native Cumbria. She has noted her 'long and deep connection' with Cumbria. She draws inspiration from light over water, tidal energy, the intent of the land combined with rich tellings of family and local memory. But her poems and prose-poems also travel the roads and the seas: from Cumbria to Kansas, New Mexico, Spain, Greece, New York, Skye and Turkey.
This poet takes her place in contemporary poetry with work that shines with joy in and respect for language. The vitality of life's many experiences are evoked here with all the senses. - Penelope Shuttle
"Geraldine Green's poems are alert to landscape, seasons, rootedness that draws from deep aquifers of language, change that flits like cloud shadows across the page. Some seemed light as thistle heads but proved enduringly strong, rich with seed. As I read, I almost expected goldfinches to feed alongside me with their otherworldly attentiveness. But that attentiveness was all hers." - Graham Mort
"Passio is a high-wire act where risk, desire and accomplishment create poems of precarious and touching beauty. There is a mythic quality to much of the work here; each poem a mantra of what is possible if we're prepared to become – and remain – astonished by our lives." – Professor Graham Mort
"Her personal travails find quiet relief in the memories of her pilgrimage and travel, which in turn generously spice her poems. She conveys memories so naturally, whether imagined, evolutionary, or conscious. The past is always present through language and memory. They don't exist without each other." – Mary Jo Malo – Unlikely Stories
"Geraldine Green has to invent her own language to express her wonder and pity for the wasted world and its oiled words" – Giles Darvill, Reviewer, SOUTH Magazine
"And with both exuberance and sadness, on an uncharted adventure and uncertain in a backwater, and with a language that's new-found, new-made for what is needed." – David Hart, Freelance Writer/Poet
"Geraldine writes like no-one else, with a visionary imagination that seems in a direct line from Blake and the English Romantics." – Charles Johnson, Poet, Editor, Obsessed with Pipework
"Her infectious enthusiasm informs a created world which integrates the vocabulary of her locality with the universality of transcendent vision" – George Wallace NY Poet
"The Beloit Poetry, one of America's most venerable, famously reads submissions aloud. If they read Geraldine Green's poems aloud they will think inevitably of e e cummings' regard for punctuation as impediment. Her very first poem, "Me and Janine," is full of information and yet it tells its story—sings it—without punctuation simply because Green's mind possesses unerring musicality. She thinks musically whereas some poets translate their thoughts into music. The difference shows up again and again in this remarkable, stylistically diverse manuscript, The Other Side of the Bridge." – Djelloul Marbrook blogs at www.djelloulmarbrook.com
"These are poems of vivid and compelling energy. Nature is a living presence throughout these poems, which are spontaneous, alert, and rich in transformations. Landscape is this poet's muse, be it her native Cumbria or Long Island or the Mid West. Memory is also a rich seam for this poet." – Review of The Other Side of the Bridge Penelope Shuttle
"Geraldine Green's THE OTHER SIDE OF THE BRIDGE delights with poems that travel from the Lake District to Greece to a Sac and Fox powwow in Oklahoma. Green's voice is fresh and full of verve. Her sharp sense of place is presented in a fusion of past and present. Her unique music and ability to capture personality through her characters' chatter enlivens her work. She sees the world as lush and does not skimp in invoking its magic, mystery and myths. Readers can never be sure where her words will carry them, even from the beginning of a phrase to the end of it. The surprises may startle, but each leap of imagination and language quickly seems perfectly apt. This is a volume to be read and re-read." – Carol Hamilton, former Poet Laureate, Oklahoma
"These are poems brimming with deep generosity. Although a faithful chronicler of Northern life, she holds out her arms to people across the world. She is a listener, a storyteller, working carefully with language to find the colours of reality. She is concerned with humanity, showing tenderness and curiosity in intimate writing revelling in the joys of love, or in poems where she stands as a witness to other times, other places, unafraid of the dark. Giving voice to those who often go unheard, she widens our knowledge and engages our imagination." – Rose Flint
Reviews on Salt Road:
Steven Matthews, Books Cumbria
Sue Sims, Poetry Space


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UV-induced p53 activation promotes cutaneous pigmentation by increasing transcriptional activity of pro-opiomelanocortin (POMC) in the skin. Induction of POMC/α-melanocyte-stimulating hormone (α-MSH) activates the melanocortin 1 receptor (MC1R), resulting in skin pigmentation. The common p53 codon 72 polymorphism alters the protein's transcriptional activity, which may influence the UV-induced tanning response. We assessed the association of the p53 codon 72 polymorphism with tanning response, and its interaction with MC1R variants on tanning response and skin cancer risk, in a nested case-control study within the Nurses' Health Study (NHS) (219 melanoma cases, 286 squamous cell carcinoma (SCC) cases, 300 basal cell carcinoma (BCC) cases and 874 controls), and among controls from four nested case-control studies within the NHS. We found that the p53 Pro allele was positively associated with childhood tanning response only among black/dark brown haired women. Compared with the Arg/Arg genotype, odds ratios (ORs) of childhood tanning tendency for Arg/Pro and Pro/Pro genotypes were 1.59 (95%CI, 0.96-2.65) and 1.56 (95%CI, 0.55-4.40), respectively. The association between MC1R variants and childhood tanning tendency was similar in both p53 Arg/Arg genotype and Pro allele carriers (Arg/Pro or Pro/Pro). The association of the p53 Pro/Pro genotype with melanoma risk was strongest among women with light pigmentation, and with MC1R variants, with the joint risk categories having the highest overall risk. We did not observe such interaction for SCC and BCC. Our study suggests the involvement of p53 codon 72 polymorphism in the skin tanning response and potential interaction with skin pigmentation on melanoma risk. Further work is needed to evaluate the association between p53 and its associated proteins and skin cancer risk.
Ultraviolet (UV) radiation is a cause of skin cancer 1-3. UV radiation induces DNA damage, producing cyclobutane-type pyrimidine dimmers (CPD) and pyrimidine pyrimidone or photoproducts 4-6. It has been shown that p53 is involved in cell cycle arrest and apoptosis in response to UV-induced DNA damage 7,8.
Most recently, Cui et al. reported a new genoprotective function of p53 by stimulating the suntan response. They showed that the tanning response is partially controlled by p53 9. Tanning is acquired pigmentation that results from exposure to UV 10. UV-induced pigmentation is the result of melanin synthesis by cutaneous melanocytes and transportation into adjacent keratinocytes 11. Melanin production is initiated by α-melanocyte-stimulating hormone (α-MSH), which is produced by proteolysis from a multicomponent precursor polypeptide, encoded by the pro-opiomelanocortin (POMC) gene 12. The induced POMC/α-MSH binds to MC1R, which further activates the cAMP signaling system, leading to eumelanin production. UV-induced p53 activation promotes transient pigmentation by increasing transcriptional activation of POMC in the skin (Figure 1).
A common p53 gene polymorphism is a G/C substitution at codon 72 in exon 4, which occurs in a proline-rich domain of p53 that is essential for p53-mediated apoptosis 13,14. This polymorphism encodes the amino acids Proline (Pro) and Arginine (Arg), resulting in two structurally distinct forms of the protein 15. It has been reported that the Pro allele has higher transcriptional activity and lower capacity to induce apoptosis 16,17.
It is known that MC1R is a major determining factor for pigment phenotype 18. A genotype-phenotype relationship has been reported for certain MC1R variants and light pigmentation. We reported that the red hair color (RHC) variants are associated with red hair, fair skin color, and childhood tanning tendency 19.
We evaluated the effect of the p53 codon 72 polymorphism on tanning response and its interaction with MC1R variants on tanning response and skin cancer risk in a nested case-control study within the Nurses' Health Study (NHS).
The NHS was established in 1976, when 121,700 female registered nurses between the ages of 30 and 55, residing in 11 larger U.S. states, completed a self-administered questionnaire on their medical histories and baseline health-related exposures. Updated information has been obtained by questionnaires every 2 years. Between 1989 and 1990, blood samples were collected from 32,826 of the cohort members. The distributions of risk factors for skin cancer were very similar in the subcohort of those who donated blood samples as in the overall cohort 19. Eligible cases in this study consisted of women with incident skin cancer from the subcohort who had given a blood specimen, including SCC and BCC cases with a diagnosis anytime after blood collection up to June 1, 1998 and melanoma cases up to June 1, 2000 that had no previously diagnosed skin cancer. A common control series was randomly selected from participants who gave a blood sample and were free of diagnosed skin cancer up to and including the questionnaire cycle in which the case was diagnosed. One or two controls were matched to each case by year of birth (±1 year) and self-reported race (Caucasian/missing). Less than 5% of cases and controls had missing race/ethnicity. The participation rate of cases and controls were 92% and 89%, respectively. The nested case-control study consisted of 219 melanoma cases, 286 SCC cases, 300 BCC cases and 874 matched controls. The study protocol was approved by the Committee on Use of Human Subjects of the Brigham and Women's Hospital, Boston, MA.
Information regarding skin cancer risk factors was obtained from the prospective biennial questionnaires and a retrospective supplementary questionnaire. Questions on natural hair color and childhood and adolescent tanning tendency were asked in the 1982 prospective questionnaire and for the ethnic group in the 1992 questionnaire. The question for childhood and adolescent tanning tendency was "as a child or adolescent, after repeated sun exposures, e.g., a two-week vacation outdoors, what kind of tan would you get?", and the multiple choices were practically none, light tan, average tan, and deep tan. In the skin cancer nested case-control study, natural skin color and other sun exposure-related information were collected by the retrospective supplementary questionnaire in 2002. In addition, the 11 states of residence of cohort members at baseline were grouped into 3 regions: Northeast (Connecticut, Massachusetts, Maryland, New Jersey, New York, and Pennsylvania), Northcentral (Michigan and Ohio) and West and South (California, Texas, and Florida). Estimation of past sunlight exposure for each subject was described previously 20.
The distribution and frequency of MC1R variants in 179 Caucasian controls from the US were determined by Kanetsky et al. using a direct sequencing method 21. Seven nonsynonymous polymorphisms with allele frequency above 1% were identified (Val60Leu, Val92Met, Arg151Cys, Ile155Thr, Arg160Trp, Arg163Gln, and Asp294His) in the coding region and were genotyped in our case-control study. The frequency distribution of MC1R variants in our study has been previously reported 19.
The Arg160Trp polymorphism of the MC1R gene was genotyped by restriction fragment length polymorphism (RFLP). Other MC1R polymorphisms and the p53 Arg72Pro polymorphism were genotyped by the 5′ nuclease assay (TaqMan®) in 384-well format, using the ABI PRISM 7900HT Sequence Detection System (Applied Biosystems, Foster City, CA). TaqMan® primers and probes were designed using the Primer Express® Oligo Design software v2.0 (ABI PRISM). Laboratory personnel were blinded to case-control status, and blinded quality control samples were inserted to validate genotyping procedures; concordance for the blinded samples was 100%. Primers, probes, and conditions for genotyping assays are available upon request.
In addition to the skin cancer nested case-control study, we had previously genotyped the p53 codon 72 polymorphism among the participants in nested case-control studies of colon cancer, colon polyps, and breast cancer within the NHS. To increase statistical power, we assessed the association between the p53 Arg72Pro polymorphism and childhood tanning tendency according to hair color among controls from all four studies. We used all controls in the skin cancer nested case-control study to evaluate the interaction between the p53 polymorphism and MC1R genotypes on childhood tanning tendency. We compared each type of skin cancer to the common control series in the skin cancer nested case-control study to increase the statistical power.
We classified the MC1R variants as follows; the Arg151Cys, Arg160Trp and Asp294His variants were categorized as "red hair color" (RHC) variants; the other 4 variants were referred to as "nonred hair color" (NRHC) variants 22-24. We also defined the chromosome without the MC1R variant at any of the 7 polymorphic sites that we genotyped as the consensus allele (WT). We used a χ2 test to assess whether the MC1R genotypes and the p53 genotype were in Hardy-Weinberg equilibrium among the controls (the distributions of two genotypes were in Hardy-Weinberg equilibrium), and the relation between the p53 genotype and childhood tanning tendency according to hair color among the controls. A test for trend was calculated across the three p53 genotypes. Unconditional logistic regression was used to estimate the association between the p53 genotype and childhood tanning tendency.
Interactions between the MC1R genotypes and the p53 polymorphism on childhood tanning tendency and skin cancer risk were evaluated in unconditional logistic regression models. Unconditional logistic regression was also employed to assess the interaction between p53 polymorphism and MC1R variants, hair color, and constitutional susceptibility score on skin cancer risk. We used cross-classified categories of the p53 polymorphism and MC1R genotypes (or hair color or a constitutional susceptibility score) compared to a common reference category. We modeled these predictors as ordinal variables to test the statistical significance of a single multiplicative interaction term. To summarize multiple constitutional phenotypic variables, we constructed a multivariate confounder score for skin cancer 25. Briefly, we applied the logistic regression coefficients from a multivariate model, including age, race, natural skin color, natural hair color, childhood or adolescent tendency to burn, and the number of palpably raised moles on arms, to each individual's values for the latter four variables and summed the values to compute a susceptibility risk score in the logit scale. We used this score to define women with low, intermediate, and high constitutional susceptibility based on tertiles among controls.
A detailed description of the characteristics of cases and controls in the skin cancer nested case-control study was reported elsewhere 19. In brief, at the beginning of the follow-up of this nested case-control study, the nurses were between 43 and 68 years old with a mean age of 58.7. The mean age at diagnosis of melanoma was 63.4. Those with skin cancers were more likely to have used sunlamps or attended tanning salons. A family history of skin cancer was a risk factor for melanoma. Those with skin cancers had higher cumulative sun exposure while wearing a bathing suit, more lifetime severe sunburns that blistered, and a higher constitutional susceptibility score.
We evaluated the association between the p53 Arg72Pro polymorphism and childhood tanning tendency according to hair color among controls from four nested case-control studies. A borderline positive association of the Pro/Pro genotype with childhood tanning tendency was observed among women who had black/dark brown hair. Compared with Arg/Arg genotype, odds ratio (ORs) of childhood tanning tendency for Arg/Pro and Pro/Pro genotypes were 1.59 (95% confidence interval (CI), 0.96–2.65) and 1.56 (95%CI, 0.55-4.40), respectively (P, trend, 0.08) (Table 1). No association was observed among women who had light hair (P, trend, 0.79) and red/blonde hair (P, trend, 0.54) (Table 1).
We evaluated the interaction between the p53 Arg72Pro polymorphism and MC1R variants on childhood tanning tendency among controls in the nested case-control study of skin cancer (Table 2). As compared with women with MC1R WT/WT genotype and p53 Arg/Arg genotype, MC1R variants were significantly associated with childhood tanning tendency regardless of the p53 genotype (p, interaction, 0.55). The association between MC1R variants and childhood tanning tendency was similar in both the p53 Arg/Arg carriers and other p53 genotypes carriers. Similarly, no significant interaction was observed between p53 Arg72Pro polymorphism and MC1R variants on hair color and childhood sunburn reaction. Women carrying MC1R variants were more likely to have red hair color or childhood sunburn reactions, and p53 Arg72Pro polymorphism did not significantly modify these associations (Supplementary Table 1).
We evaluated the interaction between p53 Arg72Pro polymorphism and hair color on melanoma risk (Table 3). Compared to women with p53 Arg/Arg genotype and black/dark hair color, we observed that the effect of the p53 Pro/Pro genotype was strongest for melanoma risk among the women who had blonde/red hair color (OR, 10.51; 95% CI, 3.14-35.22) (p, trend, 0.04) (Table 3). The test for departure from multiplicative interaction between the p53 Arg72Pro polymorphism and blonde/red hair color was not statistically significant (p, interaction, 0.67), suggesting that these are independent risk factors and their combination gives rise to an approximately multiplicative level of risk. A similar result was found when we further evaluated the interaction between p53 Arg72Pro polymorphism and MC1R variants on melanoma risk (OR, 10.66; 95% CI, 1.93-58.92) (Table 4). This OR was attenuated after controlling for skin color and hair color, but the pattern or multiplicative risk remained (OR, 6.97; 95% CI, 1.23-39.60) (Table 4).
We also evaluated the interaction between p53 Arg72Pro polymorphism and the constitutional susceptibility score on melanoma risk (Table 5). The interaction pattern was similar to those between p53 Arg72Pro polymorphism and hair color and MC1R variants on melanoma risk. The constitutional susceptibility score that we used reflects general constitutional susceptibility index for skin cancer. Compared to women with low constitutional susceptibility scores and p53 Arg/Arg genotype, the p53 Pro/Pro carriers with high constitutional susceptibility scores had significantly increased risk of melanoma (OR, 7.09; 95% CI, 2.69-18.66) (p, trend, 0.01), whereas the women who had p53 Arg/Arg genotype and high constitutional susceptibility scores showed an OR of 3.00 (95% CI, 1.69-5.33) (p, interaction, 0.15).
Additionally, we evaluated the interactions between p53 Arg72Pro polymorphism and hair color, MC1R variants, and constitutional susceptibility score on the risks of SCC and BCC. There were no significant interactions observed (Supplementary Tables 2, 3, and 4).
A newly discovered important protective role of p53 was its ability to regulate the suntan response. Cui et al. found that p53 can directly modulate transcriptional activity of the POMC promoter following UV exposure 9. It is notable that the prevalence of p53 Arg72Pro polymorphism exhibits substantial latitudinal differences, with dark pigmented populations closer to the equator having increased Pro allele frequency 26,27. In this regard, it is speculated that p53 Pro allele is a more competent inducer of POMC transcription, an evolutionary selection in heavily sun-exposed areas 28. This speculation is consistent with the fact that the Pro allele was associated with increased transcriptional activity 17 . In this study, we evaluated the association between p53 Arg72Pro polymorphism and childhood tanning tendency according to different hair color. At the outset, we surmised that the effect of functional p53 polymorphism on tanning responses could only be evaluated in individuals with an intact MC1R pathway, e.g. in individuals with MC1R polymorphisms resulting in red hair, we would not be able to evaluate the effect of p53 as tanning responses are poor. As expected, only among the women with black/dark brown hair, the test for trend showed a borderline positive correlation of Pro allele with childhood tanning tendency. This finding may provide a plausible molecular explanation for different tanning response to UV among people with similar pigmentation.
The melanocortin 1 receptor (MC1R) gene is located at 16q24.3. It encodes a seven-transmembrane, G-protein-coupled receptor of 317 amino acids, and can be activated by its ligand α-MSH or adrenocorticotrophic hormone (ACTH) 29,30. Valverde et al. illustrated that variants in the coding region of the MC1R play an important role in tanning and pigmentation in humans 24. MC1R variants encode receptor proteins with decreased function to increase cAMP, resulting in decreased constitutional and transient pigmentation 31,32. We found that the women with RHC variants are less likely to tan; these associations were not modified by the p53 Arg72Pro polymorphism. The role of MC1R in skin pigmentation is predominant, and the variants of MC1R, especially RHC alleles, are consistently associated with constitutional and transient pigmentation 19. This result suggests that the propensity of the p53 Arg72Pro to increase the tanning response is mitigated by the strong influence of MC1R variants in the POMC/α-MSH-induced tanning response.
Previous studies reported that MC1R variants are associated with an increased risk of developing melanoma and are also associated with phenotypic features such as fair skin and red hair, which are strong risk factors for skin cancer 33-36. These observations are consistent with the findings of this study; i.e., the women who had MC1R RHC variants or red hair had statistically increased risk of melanoma. Similar result was also found for the women with high constitutional susceptibility score. The constitutional susceptibility score reflects the multiple constitutional phenotypic variables including hair color, skin color, childhood tendency to burn, and the number of palpably raised moles on arms, simultaneously. Interestingly, these associations were strongest among women who carried the p53 Pro/Pro genotype; namely, darker pigmentation substantially attenuated the melanoma risk associated with p53 Pro/Pro genotype. In an analysis on the same participants from this study, Han et al. observed that the Pro/Pro genotype carriers had higher melanoma risk than the Arg/Arg genotype carriers 37. In the present study, we observed that the p53 Pro allele was more strongly associated with tanning response among dark haired women, presumably those retaining substantial function of MC1R. These data suggest that the p53 Pro allele maybe a more active transcription factor of POMC than the Arg allele in tanning response, resulting in darker pigmentation. However, the Pro allele is associated with lower capacity to induce apoptosis than the Arg allele 16. Hence, even though the Pro allele is associated with tanning response, its reduced activity to induce apoptosis plays a predominant role in melanoma development among Caucasians.
The nested case-control design, high follow-up rate, and high response rate for the retrospective supplementary questionnaire are among strengths of this study. The limitations of the study include self-reported assessment of pigmentary phenotypes, which may lead to misclassification. Nevertheless, we observed that the Pro allele was associated with tanning response, probably due to enhanced induction of POMC transcription. The association of the p53 Pro/Pro genotype with cutaneous melanoma risk was strongest among the women with light pigmentation. The underlying mechanism of the p53 Arg72Pro polymorphism in the etiology of cutaneous melanoma remains to be demonstrated.
Supplementary Table 1. Interaction between the p53 Arg72Pro polymorphism and MC1R variants on hair color and childhood sunburn reaction among controls
Supplementary Table 2. SCC and BCC risks by p53 Arg72Pro polymorphism and hair color
Supplementary Table 3. SCC and BCC risks by p53 Arg72Pro polymorphism and MC1R variants
Supplementary Table 4. SCC and BCC risks by p53 Arg72Pro polymorphism and constitutional susceptibility score
Grant sponsor: NIH; Grant numbers: CA113100, CA128080, and CA087969.
We thank Dr. David E. Fisher at Dana-Farber Cancer Institute for scientific discussion, Ms. Carolyn Guo for her programming support. We are indebted to the participants in the Nurses' Health Study for their dedication and commitment.
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


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Titled "100 things to do in Tasmania before you die", Experience Oz have compiled a list of experiences not to miss while in our beautiful island state.
We're pleased to be featured at #17 – snugly between Salamanca Markets and The Wall – and we're pretty excited.
Be sure to check out the full list and get around to all the experiences while you can!