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A MOTHER accused of murdering three of her own babies broke down in the witness box yesterday as she insisted she had not smothered the children she loved.
Trupti Patel, 35, said she and her husband Jay had always wanted a sibling for their surviving first child to make a "complete" family.
She fought back tears and at times wept uncontrollably as she denied murdering her two baby sons, Amar and Jamie, and daughter Mia - none of whom survived beyond the age of three months.
All three children collapsed suddenly at the Patel's family home in Maidenhead, Berkshire, in separate incidents between 1997 and 2001, and later died in hospital.
Patel, who revealed she had suffered a miscarriage before the birth of her first child, said she and her husband had always wanted two children.
But she said they had been so distressed by the three deaths that they would not be having any more children and that her husband Jay was even considering having a vasectomy.
She also revealed that since her arrest, she had discovered that her maternal grandmother in India had lost five children in infancy, while there had been three infant deaths on her husband's side of the family.
Patel said she had loved all of her children and had kept special boxes containing "memories" of each of her babies that died.
She said that when her daughter Mia - the third child to die - became ill suddenly on June 3, 2001, her reaction was one of 'complete shock'.
"I could not believe that it could happen three times," she said.
The trial at Reading Crown Court heard how Patel put Mia to bed in her crib before going to sleep herself around lunchtime.
She was awoken by her mother who walked into the bedroom to discover that Mia did not appear to be breathing and that she looked 'drained'.
Mia had a mattress breathing monitor in her crib, but it had not set off the alarm, Patel said.
She said she tried desperately to resuscitate her daughter while her husband phoned for an ambulance, but her attempts "did not appear to make much difference".
Mia died later in hospital and a post-mortem examination revealed she had four fractured ribs. Patel denied she had broken them while trying to smother her daughter.
Defending, Kieran Coonan QC asked Patel, "Did you deliberately break those ribs?"
"No, I was trying to save her life," said Patel, breaking down in tears.
Patel said she had received counselling from the Child Bereavement Trust over the past few years and said she and her husband had attended a conference on Sudden Infant Death Syndrome and researched the subject on the internet.
She said they had also taken advice from doctors about the possibility of some sort of genetic illness which could account for the deaths of her children.
And she revealed that having had those discussions, she was "overjoyed" when she discovered her fourth child, Mia, was a girl, following the deaths of her two sons.
Earlier Mr Coonan had discussed the deaths of her two sons with Patel.
He asked her, "Amar died at three months old. Did you love him?"
"Yes," replied Patel, who began crying.
"Did you smother him?" asked Mr Coonan.
"No," replied Patel, who broke down in the witness box and was shaking as she struggled to control her tears.
Patel admitted she had been anxious about Jamie and agreed she had told a nurse who came to visit her at home that she wanted to enjoy him "for as long as possible, while we still have him".
"Was there anything sinister in that?" asked Mr Coonan.
"I do not think so," said Patel.
When asked to explain what she meant, Patel said, "We have anxieties about whether Jamie might die and in the meantime we wanted to enjoy him just as a baby, not to have any worries."
Patel said that after the case she expected to return to her family where her husband would "welcome me home".
The hearing continues today.


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So my idea is along the same lines as Twitter & Facebook using @ (AT) mentions of usernames, the functionality of suggestion within member search is already there, wondered if that could be taking a step earlier so users receive an alert if their username has received an @ mention? I think it might be a useful way of people keeping track of when they get a mention, both in threads and profile posts.
Imagine the complex side to this would be permissions and @ mentions not being possible in Private Conversations?


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I lied about having my first kiss already and this really cute guy wants to hook up and I said yes but he thinks I'm like a good kisser cause I've dated a lot of guys but I've never kissed any of them. So he'll be my first can this turn out good? What do I do?
Most Helpful Guy
Practice on your forearm also you might watch a bit of hollywood style kissing. It's not perfect but it's a start. You'll find that once you start kissing it comes quite naturally so just follow you instinctsand don't try too hard.00|00|0
Most Helpful Girl
How do you date a lot of guys without kissing them? Im curious.00|00|0
we just went out to dates and and kisses on the cheek and hand holding. None of my relationships are ever longer than a week. That's why I date a lot. I'm over ot so I just want to do a hook up. Just making out and teasing each other


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A profitable trading rule for net borrowers on settlement Wednesday
No abstract is available for this item.
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Volume (Year): 39 (1999)
Issue (Month): 1 ()
Pages: 129-146
|Contact details of provider:
| Web page: http://www.elsevier.com/locate/inca/620167
References listed on IDEAS
Please report citation or reference errors to , or , if you are the registered author of the cited work, log in to your RePEc Author Service profile, click on "citations" and make appropriate adjustments.:
- Griffiths, Mark D. & Winters, Drew B., 1995. "Day-of-the-week effects in federal funds rates: Further empirical findings," Journal of Banking & Finance, Elsevier, vol. 19(7), pages 1265-1284, October.
- Cukierman, Alex & Meltzer, Allan H, 1986. "A Theory of Ambiguity, Credibility, and Inflation under Discretion and Asymmetric Information," Econometrica, Econometric Society, vol. 54(5), pages 1099-1128, September.
- Saunders, Anthony & Urich, Thomas, 1988. "The effects of shifts in monetary policy and reserve accounting regimes on bank reserve management behavior in the federal funds market," Journal of Banking & Finance, Elsevier, vol. 12(4), pages 523-535, December.
- Feinman, Joshua N, 1993. "Estimating the Open Market Desk's Daily Reaction Function," Journal of Money, Credit and Banking, Blackwell Publishing, vol. 25(2), pages 231-247, May.
- Hamilton, James D, 1996. "The Daily Market for Federal Funds," Journal of Political Economy, University of Chicago Press, vol. 104(1), pages 26-56, February.
- Allen, Linda & Peristiani, Stavros & Saunders, Anthony, 1989. "Bank Size, Collateral, and Net Purchase Behavior in the Federal Funds Market: Empirical Evidence," The Journal of Business, University of Chicago Press, vol. 62(4), pages 501-515, October.
- Goodfriend, Marvin, 1986.
"Monetary mystique: Secrecy and central banking,"
Journal of Monetary Economics,
Elsevier, vol. 17(1), pages 63-92, January.
- Marvin Goodfriend, 1985. "Monetary mystique : secrecy and central banking," Working Paper 85-07, Federal Reserve Bank of Richmond.
- Singh, Harinder & Zak, Paul, 1992. "Preliminary Evidence on the Determinants of Federal Reserve Open Market Operations," Public Choice, Springer, vol. 74(3), pages 317-338, October. Full references (including those not matched with items on IDEAS)
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Doctor insights on:
What Is The Best Treatment For Loss Of Vision
What is the best treatment for a progressive vision loss?
Eye MD: The best thing you could do is to see an ophthalmologist to determine what is happening to your vision and what to do about it. ...Read more
Blindness (Definition)
Vision impairment and blindness are conditions in which a person cannot see well or see at all, even with glasses or contact lenses. If a person's best vision (with correction) out of either eye is only 20/70 - 20/200, he is impaired. If he can see no better than 20/200 or his visual field is no more than 20 degrees (severe "tunnel" vision), ...Read more
What treatment option are there for loss of vision and ringing in ear. I have csf?
See a doctor: You should see an ophthalmologist to determine why you have loss of vision. ...Read moreSee 1 more doctor answer
Can you tell me the leading causes of loss of vision. List as many as possible not just 1 answer. Can it be curable without laser treatment?
Two categories: 1) permanent loss: inherited disease, birth defects, severe injury, advanced diabetic disease, retinal vascular occlusion brain stroke, macular degeneration--and others 2) correctable loss: glaucoma, cataracts, vitamin deficiencies, surface infection, corneal opacities, multiple sclerosis, early diabetic changes -- and others. There are many paths to correction or cure; laser also. ...Read more
Recently diagnosed with glaucoma. No peripheral vision loss. 30% optic nerve damage. With treatment will nerve damage cause loss of vision?
Probably not: Glaucoma is readily treated with anti-pressure medication which should prevent any further damage in almost all cases. This is handled by ophthalmologists (you are not seeing an optometrist i hope?) who deal with this daily. There is a step ladder of treatments -- medication, laser, surgery to prevent further damage which can be quite effective. ...Read moreSee 2 more doctor answers
I'm 58 recently diagnosed w/glaucoma & beginnings of peripheral vision loss. Please explain what aggressive treatment would mean for me?
Treatment: Of glaucoma is individualized. For each, a target pressure is set depending on the untreated pressure (usually 30% lower). Then the ophthalmologist adds treatment until this is reached. More aggressive treatment means setting a lower goal and closer follow up. ...Read moreSee 2 more doctor answers
With treatment can a 58 year old with 30 percent optic nerve damage avoid significant vision loss in their lifetime?
Depends on the cause: If your vision loss is from compression of the nerve from a tumor it is best to get it treated asap to prevent further loss. Optic nerve damage may not improve if the damage is severe. ...Read moreSee 1 more doctor answer
Dr says glaucoma caught early w/30% nerve damage & minimal peripheral vision loss. Begun treatment. Only 58 yrs. Old. What is long-term prognosis?
Good: The prognosis is good if you use the medications as directed and keep all follow up appointments with your ophthalmologist. ...Read moreSee 1 more doctor answer
Can laser photocoagulation be used to treat macular degeneration? I was recently diagnosed with the "dry" form of macular degeneration. Is having laser photocoagulation a treatment option available to me, and would this prevent further vision loss?
Laser no help: Laser for dry macular degeneration has been studied well. Laser to the macula of dry amd patients makes drusen go away, so it looks better on exam. The laser does not change whether or not there is vision loss. Vitamin supplementation is the only proven preventive therapy, and reduces the risk of vision loss by about 25%. The vitamin formula now recommended is called areds 2 formula. ...Read moreSee 2 more doctor answers
Glaucoma 30% nerve damage with some peripheral vision loss. Have started treatment. Dr said at 50% damage i would notice vision loss. Sound right?
Not likely: In my experience, patients with glaucoma rarely notice the loss of vision until it is far advanced. Also there is no reliable way to estimate the percentage loss of nerve. We generally judge the extent of disease with the peripheral vision test as mild, moderate or severe. ...Read more
Dr says glaucoma caught early w/30% nerve damage & some peripheral vision loss. Said w/out treatment could've been blind in 7 yrs. Can go that fast?
Depends: It depends on many factors, but the general rule of thumb is that it the higher the pressure, the faster vision loss can occur. The goal of glaucoma treatment is to lower the pressure to the point that vision loss does not progress or slows to the point that you will never go blind during your lifetime. ...Read moreSee 1 more doctor answer
Vision (Definition)
Vision is a feature of a person's brain that allows him to see. He must have normal eyes, optic nerves (that stretch from the eyes to the back of his brain), and visual cortex (the vision center in the brain), in order to see properly. An ophthalmologist is a ...Read more
Vision Loss (Definition)
Vision loss is where a person becomes unable to see to the extent that they were previously able. This can include a total loss of vision, a loss of visual acuity, or a loss of part ...Read more
- Talk to a doctor live online for free
- What is the best treatment for peripheral vision loss?
- What is the best treatment for tunnel vision?
- What is the best treatment for double vision?
- Ask a doctor a question free online
- What is the best treatment for blurred vision?
- What is the best treatment for vision distortion?
- What is the best treatment for distorted vision?
- What is the best treatment for cloudy vision?
- Talk to a ophthalmologist online for free


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Now this is so adorable!
Soori the meerkat is one of the animals at the British animal shelter Oreo and Friends Animal Encounters who started off with just one rescued raccoon named Oreo.
This video went viral over the internet during the weekend. People can't help but adore cute little Soori. It cannot help nodding while sitting up. The meerkat looks exactly like a sleepy toddler who wants to stay awake but just can't.
Watch the YouTube video above and see little Soori jolting over and over again.


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How about Santa Maria in the far northern reaches of Santa Barbara County. I'm still considered local at Disneyland! Am I good for the So Cal group? I'm brand new to smoking and looking forward to learning from all of you!
- 55 Posts. Joined 7/2013
- Location: Santa Maria, on the Central Coast of California
- Points: 11
- Select All Posts By This User


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Most people have kinks. A kink is something that makes someone sexually excited when the action is being performed or a thing is brought into a sexual situation. This is a very vague definition and many other things can fall into the umbrella of being a kink but most kinks concern either a certain action or object. You might have a kink and you don't even know it because you didn't know that's what you could call it. The eHarmony's relationship promise might be nice when using the eharmony dating site which has been reviewed and ranked against others, but it's a bit bland sex wise. Your relationship partner probably has a kink too and they may not be comfortable enough to tell you what it is. Kinks can be embarrassing, especially if they aren't typical or involve some outrageous things. Or perhaps your partner has disclosed their kinks to you and you aren't sure if you really want to get involved. It's important to at least put some thought into your partner's kinks, though.
You Want to Make Your Lover Happy
Being in a relationship is about both getting and giving. This means that you have to be able to be open emotionally and also shoulder the emotions of the person you love. If your partner gives you love then you give it back. That's what makes a relationship as good as it can be. There has to be a mutual exchange of feelings and love in order to have a healthy and happy partnership. Sites like the match.com online dating sites show you how it compares to others by testing it and posting reviewed and ranked against the competition information for that site. This is just as true when it comes to the bedroom. If someone is being fulfilled while someone isn't when it comes to being between the sheets then that isn't a healthy sex life. Trying out your kinks isn't exactly a right but it's something that your partner should consider. This is also true for you and your partner's kinks. Unless the kink makes you wholly uncomfortable then there's no harm in trying it out.
Sex can get boring, believe it or not. Most aren't satisfied by doing the same things over and over again in the bedroom. Some don't mind it and prefer it but people are creatures that are innovative and adventurous. Spice in the bedroom drives chemistry and switching things up every once in a while can bring you closer both emotionally and intimately. In the ongoing establishedmen.com controversy these guys say still a good site to use for dating even after the avid life media fiasco. This is why kink sharing is so important. It opens doors into your partner's emotional closet. Most people are not readily willing to lay their sexual fixations on the line so when your partner does then you know they're really serious and letting themselves be vulnerable around you. You owe it consider their request but also, it's not so bad to at least try it to do something new. Kinks are like food: you won't know if you really don't like it until you try it.
Deciding What You Do and Don't Like in Bed
You might have been the kind of kid that was a picky eater. There might have been screaming matches with your mother about how you definitely were not eating those brussel sprouts or your peas. As you grew, though, did you notice that these things didn't seem as threatening to you? You might have even found out that you like these things as your taste buds matured.
Kinks are things that you don't really have a real idea of until you actually experience them or see them as they are meant to be. You can't just hear a kink and know that you just would not enjoy that in any sense. Some kinks that are extreme and involve pain or underage play will be immediate turnoffs for good reason, but can you really say that you wouldn't enjoy roleplaying or food kink without actually experiencing it?
You Don't Have to Commit to Anything
Everyone likes to try before they buy. That's why people like to test drive cars before they put down cash. You can at least try a kink out with your partner to make them happy and give yourself some experience. If you don't like it then you don't have to do it again or can say that you'll only do it on special occasions. If you do like it then you can continue on with your relationship while enjoying yourselves with new sexual ideas and practices.
When you're seeing a woman that you really like, one of the things you definitely want to do is make sure that you can get her family to be crazy about you. Making her family love you shouldn't be too difficult depending on what type of personalities they have and what type of person you are. Even if her family seems to be uptight, there are many things that you can do to convince her family that you are a great guy and that she is safe with you. But before you can do any of that, you will have to find out from her what type of people her family members are well in advance before you can begin putting your plan into action.
Don't Be Afraid to Ask Detailed Questions About Her
When you want her family to love you, the first thing you need to do is ask detailed questions about them before you actually meet them. Ask her things like what her parents and siblings do for work, and whether or not they enjoy their jobs. You should also ask her about any big arguments that they've had with her or with each other. Find out about things that they absolutely despise and about even the smallest pet peeves that drive them crazy. She may not know the answers to all of your questions, but she should be able to put you in the right direction.
Once you're satisfied with her answers, you should then begin working on the areas in your own personality that you need to polish up before meeting her folks. For instance, if you know her father hates it when people use profanity and you can't go two sentences without letting a swear word slip out, try to make a conscious effort of not cursing, so that when you finally do meet her father your chances of cursing around him may have gone down.
Another thing you definitely want to do in order to make her family love you is to be yourself and don't try to say what you think they want to hear. Many parents want a person for their daughter who is willing to stand up for himself because that means he will stand up for her. If you are doing things like agreeing with them about everything they say, it can make you seem like you are kissing up to them, and that you are really up to no good. If you find yourself disagreeing with someone in her family, make sure you announce that you understand your view, but that you disagree. The space is riddled with scams but there are warning signs that help you identify this and avoid bad sites. In those situations where the conversation topic is taboo, try to excuse yourself so that you don't have to answer the question. Some people can get heated over some topics, and you don't want to end up ruining the night by arguing with one of her relatives. Making her family love you is simple and easy to do. All it really takes is for you to learn about her family members, so that you know what to expect from them when you meet them.
Relationships can be complicated and frustrating even though they're worth the struggle. However, if you're in a relationship where you feel like things aren't going as well as you would like them to, it can become more trouble than it's worth, and it can be quite upsetting. If you are dealing with a situation where you feel like things aren't going well, you might be wondering what could be the source of the struggle. If your boyfriend or partner isn't happy with the relationship, then that could be the source of all your problems. It's not always easy to tell if this is the type of situation you're dealing with, but if you do feel like things aren't going as well as they should be, you'll want to be able to recognize the signs that he's unhappy with your relationship. It could signal the beginning of the end, or it could just mean that you both have a few things you need to work out. Either way, here are five common signs that he may be unhappy with the relationship and how it's going:
1. He Doesn't Spend as Much Time with You
If you notice that your boyfriend is starting to spend much less time with you, this could definitely be a sign that he's starting to drift away from you. You should definitely look into things before you jump to any conclusions, of course. He could just be busy with work or other things in his life. However, if you've ruled out any obvious things that would be taking up more of his time than usual, then you should consider the fact that he may not be happy with your relationship. It could be a sign that he's starting to pull away in the hopes of the relationship ending, so don't brush this off as not being worth considering. There's good tips on rope is dope for roping basics in bondage giving you a good foundation.
2. He Talks and Flirts with Tons of Other Women
This should be a fairly obvious sign that something is up, but maybe you're just hoping it will pass. If he starts flirting with tons of other women when you're around, then he could be trying to show you that he's unhappy with the relationship. It's definitely not an acceptable thing for a guy to do in a relationship, so if he's not trying to hint something to you, then at the very least he's not someone you should be dating. You deserve someone who will be faithful to you, so make sure to keep an eye on his behavior if he starts doing this sort of thing to you.
3. He Stops Asking You out on Dates
If you've been dating for a while and he suddenly stops asking you out, then something side finitely up. This could very well be a sign that he's no longer as interested in you, and that's definitely not something you want to deal with. Again, there's still a chance he may just be busy with work, but there's not any real reason why he shouldn't be trying to plan dates with you. Make sure to ask him if he has any plans for a future date, because this could really be a bad sign.
4. He Doesn't Open Up
If you're dealing with a boyfriend who doesn't seem to want to open up to you, you may have something to worry about. There are some guys that just don't like to share their emotions or feelings, for sure – however, there's only a certain level to which this can be acceptable. If you have been getting intimate with him and he doesn't seem to be opening up despite that change in your relationship, it might be a sign that he's ready to move on or he's just not happy with the relationship. Either way, a guy who refuses to be open with you isn't really worth your time.
5. You're Doing All the Talking
Again, some guys just aren't that talkative and that's understandable at some times. However, if you find that you're always the one doing all the talking and he never seems to be listening, this should be a huge red flag. You need to have a more equal relationship and if he isn't talking to you at all, it could be a sign that he's unhappy in the relationship. Soon enough, you won't be happy either. It could be time to split and find someone who's more willing to keep up with you, or at least you should try and talk things out with him.


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Ghana head coach Appiah: Anything is still possible
Ghana's national team head coach Kwesi Appiah still believes that any team...
Former Egypt international striker Mohamed Zidan won his case against UAE side Baniyas after being accused of 'pretending to be injured'.
$900,000 US (approximately 6.86 million EGP) was awarded to the former Baniyas striker – plus his $245,000 apartment rent paid for – after being declared innocent by the United Arab Emirates Football Association for a 'fake injury' case on Wednesday.
Mohamed Zidan, 33, had filled a complaint against his former club almost a year ago and demanded to be compensated after being accused of faking injuries, which he insisted was not true. The Abu Dhabi-based side believed that Zidan never cared about the club and always claimed to be injured, but still received his salary on time.
"The dispute-solving committee agreed that Zidan didn't fake injury during the Baniyas spell and was really injured, according to the documented medical reports," Eisa Saleh, the head of the committee, was quoted as saying in Emirati newspaper Emaratalyoum about the verdict.
Former Borussia Dortmund forward Zidan, who is keen on a return to the pitch, expressed his excitement on his social media pages.
"Thanks God, certainly the truth will never fade, even after two years," Zidan tweeted.
Zidan has been training with BVB over the winter preparing for a return to football after recovering from a knee injury.


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My 3 forms are missing - URGENTAsked by vibha_atl on August 17, 2014 at 11:12 PM
I received email that my account is out of space and if not upgraded my forms will be removed.
I added my account to our organization's (VIBHA) coordinator account, which is paid account. Why my forms were still removed?
Is there any way to get them back.
Please advise its urgent.
Thank You
JotForm Support
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I did check your account and it seems the forms are already moved from your account to your other account "vibha" with "Economy" subscription plan.
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Overlander 5000mAh 6S 22.2v 35C LiPo Battery - Supersport Pro
Overlander 5000mAh 6S 22.2v 35C LiPo Battery - Supersport Pro
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Artist Talks
Saturday 12 December / 12.45-2pm / The Box / FREE - Booking Essential
Led by Follow curators Amy Jones and Lesley Taker, this informal talk with some of the artists, and designers behind the exhibition (inc. Cécile B. Evans, Constant Dullaart, Ant Hamlyn, Candice Jacobs, Joe Orr, and Simon Whybray) considers social media, celebrity, and self-branding. After lunch, this panel will be followed by a special performance lecture by Cécile B. Evans.
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An Owl becomes Astonomy Picture of the Day
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- I think the subject title tells it all. Please go to
http://antwrp.gsfc.nasa.gov/apod/astropix.html to view the Owl that
has become the picture of the Day at Nasa's offical "astronomy
picture of the day".
Ron Storey
Petaluma, CA
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Put your OG style on blast in the newest addition to Timberland Brand's Monochromatic Colllection, the Timberland Men's 6-Inch Prem Mono Level 61 Boots (A176X410), released 03/30/16. Constructed of a premium Nubuck leather upper with padded collar and seam-sealed waterproof design, these special edition boots are draped in a stylish blanket of monochromatic navy blue from collar to outsole to keep you catching eyes and turning heads. 400 grams of PrimaLoft ECO insulation, rustproof hardware, and Timberland's exclusive anti-fatigue technology combine to bring you a tireless boot fit for long lasting wear n' tear. These men's boots are finished atop a sturdy rubber lug outsole for high-performance durability and traction. Keep it classic in the Men's Timberland 6-Inch Premium Mono Level 61. For sizing information, be sure to check our Size Chart. Looking for a store near you? Head over to our Store Locator.
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Join us at Art & Sole 2, hosted by San Jose Fashion, Art, and Music on September 1, 2010 at the Valencia Hotel Courtyard.
Art & Sole is a charity event that was created last year to showcase talent of local artists and to establish a network of fundraising events for charities. These local artists will transform blank shoes into works of art as if they were their canvas. This year's beneficiary is San Jose Downtown Association's (SJDA) Downtown Doors, which is a youth art competition and exhibit that brings together talented high school artists and property owners, resulting in public art displays that enhance downtown San Jose's urban landscape.
The event starts at 6 o' clock pm and includes a silent shoe auction, live art by featured local artists, live performance by singer Amy Serrata, music by DJ Sig-O, and give aways.
Featured artists for this year's Art & Sole are:
Orly Locquiao
Colin Baker
Erikka Hugger
Mike Aveno
Jorynn Villar
So come out and see for yourself all of the talent that is in the Silicon Valley. The $10 admission charge, silent auction, and donations will all go to charity. Also, each donator will receive a free raffle ticket. Should be a great night!


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Tummy extra fat, due partly to its spot on the system, ordinarily much more hazardous than more extra fat that adheres to other areas of system requirements this kind of starting to be thighs and buttocks. Is really truly the perfect outer image of harm staying accomplished further from the male body.
What might be exercise routines basically? Follow generally ab muscles crunches – standard crunch along with their versions. Also exercise plank. Visit the fitness center showcase superior utilization of Captain's in shape. They are exercise routines to tighten stomach muscles and oblique system.
Do not consume also substantially while using the work out. Updated ideas on key details for nutrisystem fast five instructions. Step do an extreme amount cardio it will eventually now enhance your starvation to feel inclined to try to eat a lot of foodstuff after a individual finishes training. Effort get 10-15 minutes of brisk cardio after which you can focus on resistance teaching that builds muscle mass. Considering the fact that muscle needs far more calories than body fat to be managed, you may keep the rate of metabolism boosted executing this.
Do Workouts in the morning. Early morning exercise routines may even extremely productive due to the fact it is during this age from the day wherein your tummy is vacant. That means to convey, you've lesser carbohydrate content systems. With reduce carbohydrate, dollars again assurance enhance charge of recurrence as well as the depth of one's exercise routines.
Quite a few marketplace . are hunting determine out how you can obtain a flat tummy miss out on their development; this could be considered a big setback inside a rush. It really is tricky gauge one's development when they are developing their tough six pack. Not like other exercise objectives someone can stop by your benefits.
Using a motorcycle is definitely the technique to physical exercise your belly fats absent. It really is pleasurable, it burns a whole great deal of calories, will help you reduce worry and improve your temper. Since start out making bicycle using a daily section of one's life, a behavior, you might be successful at tricks to burn off tummy excess fat for guys and gaze immediately after it which has a towel.
Unfortunately on the waistline, tastes us do not knowledge famines these days. So, that working day to use the excess suppliers of extra fat never will come. Could is just halt bringing regarding the hazard. Undergo kitchen area and be free from of meals high in saturated unwanted fat and all varieties of sugar. Commence consuming primarily entire grains, contemporary and veggies, and lean protine sames. These food items are normally very low in calories although rich in nutrition just some components to trim down.
Excess weight education is essential in aiding you lose excess body fat speedily. The development of lean muscle mass will actually raise your metabolic process and function a body weight reduction furnace even at breaks. Usually do not overlook excess weight coaching being a part of one's physical exercise regimen.


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Inner West Magic claim Club Championship honours for the 8th time in 9 years and the league bids farewell to Boomerangs FS who were unable to dodge the relegation zone by 5 points.
The Boomers have experienced 3 good seasons in the Premier League after gaining promotion in the 2011/12 season.
The 2014/15 season will welcome UTS Northside Futsal Club after earning promotion from State League in their inaugural season.


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April is a month that makes a lot of us feel excited for spring and summer! The temperature gets warmer, the sun shines brighter and the flowers are blooming all over the place. But did you know that April is also National Child Abuse Prevention Month? According to childrensdefense.org, 1,825 children in the United States were confirmed to be abused or neglected each day in 2014.
In Oklahoma, we are all mandated reporters— which means, if you see something that you think might be child abuse or neglect, according to the law, you must report it or else you could face a misdemeanor offense. A person who reports suspected abuse in "good faith" is immune from criminal or civil liability.
So what exactly is child abuse or neglect? How do you know if what you see is truly abuse or a style of parenting? Here are some definitions by childwelfare.gov on what exactly abuse and neglect are.
Physical abuse: Non-accidental physical injury (ranging from minor bruises to severe fractures or death) as a result of punching, beating, kicking, biting, shaking, throwing, stabbing, choking, hitting (with a hand, stick, strap, or other object), burning, or otherwise harming a child, that is inflicted by a parent, caregiver, or other person who has responsibility for the child. Physical discipline, such as spanking or paddling, is not considered abuse as long as it is reasonable and causes no bodily injury to the child.
Neglect: The failure of a parent, guardian, or other caregiver to provide for a child's basic needs. Neglect can be:
-Physical (example: failure to provide necessary food of shelter, or lack of appropriate supervision)
-Medical (example: failure to provide necessary medical or mental health treatment)
-Emotional (example: inattention to a child's emotional needs, failure to provide psychological care, or permitting the child to use alcohol or other drugs)
Sexual abuse: Includes activities by a parent or caregiver such as fondling a child's genitals, penetration, incest, rape, sodomy, indecent exposure, and exploitation through prostitution or the production of pornographic materials.
Emotional abuse: A pattern of behavior that impairs a child's emotional development or sense of self-worth. This may include constant criticism, threats, or rejection, as well as withholding love, support, or guidance.
*Other forms of abuse may include abandonment or substance abuse.
For a full list on how to identify if a child is potentially being abused or neglected, check out https://www.childwelfare.gov/pubpdfs/whatiscan.pdf.
So with all of that being said, there are some ways you and your family can get involved in helping bring awareness to National Child Abuse Prevention Month:
-Spread the word through social media (Facebook, Twitter, Instagram, etc.). And don't forget to use the hashtag #PreventionMonth!
-Share Oklahoma's Child Abuse Prevention video with your family, friends and coworkers! https://www.youtube.com/watch?v=ujZZOmZfPlU
-Put up a blue ribbon on your tree, door, or anywhere else you can think of! The blue ribbon is the symbol for child abuse prevention to represent the blue color of a child's bruise.
-Encourage your child to color a picture of "My Happiest Day" and post it on social media. To print the Oklahoma's coloring page, find it here: https://www.ok.gov/health2/documents/Coloring%20Template.pdf.
-Encourage your child to color a pinwheel in honor of Child Abuse Prevention Month found here: https://www.ok.gov/health2/documents/PW1.pdf.
Get involved and spread the word this month on preventing child abuse and neglect!
If you suspect something, report it. Oklahoma's Child Abuse Hotline is available 24 hours a day—call 1-800-522-3511. If the child is in immediate danger, call 911 or local law enforcement.
For the babies,


text: Home Recipes Course Desserts Pie Recipes Raspberry Pie Share: Raspberry Pie Looking for recipes for raspberry pie? Taste of Home has the best raspberry pie recipes from real cooks like you, featuring reviews, ratings, how-to videos and tips. Recipe Spotlight Deconstructed Raspberry Pie It took us a couple tries to get the crumb crust just right in this fun-to-make and even-funner-to-eat graham cracker pie. Try it with fresh strawberries or blueberries. —Healthy Cooking Test Kitchen Get Recipe More Raspberry Pie Sort: Most Relevant Highest Rated Previous Page ... 4 5 6 ... 7 Next Page Raspberry-Rhubarb Slab Pie Raspberry-Rhubarb Slab Pie "Slab pie" is a pastry baked in a jelly-roll pan and cut in slabs like a bar cookie—or a pie bar, if you will. My grandfather was a professional baker and served pieces of slab pie to his customers back in the day. Here is my spin, featuring rhubarb and gorgeous red raspberries. —Jeanne Ambrose, Milwaukee, Wisconsin View Recipe Chocolate Raspberry Pie Chocolate Raspberry Pie After tasting this pie at my sister-in-law's house, I had to have the recipe. I love the chocolate and raspberry layers separated by a dreamy cream layer. It's a joy to serve this standout treat! —Ruth Bartel, Morris, Manitoba View Recipe Favorite Fresh Raspberry Pie Favorite Fresh Raspberry Pie This pretty raspberry pie was practically a staple at our house during the late summer. Our family had raspberry bushes, so the pie was always made with fresh-picked berries. —Emily Dennis, Hancock, Michigan View Recipe Advertise with us ADVERTISEMENT Contest-Winning Raspberry Cream Pie Contest-Winning Raspberry Cream Pie This recipe is delicious with either fresh-picked or frozen raspberries. That means you can make it year-round. One bite of raspberry pie will instantly turn winter to summer. —Julie Price, Nashville, Tennessee View Recipe Very Raspberry Pie Very Raspberry Pie We live along a 130-year-old railroad track (our house once was a train station) and during a couple weeks every year, it is edged with wild raspberries. I use those raspberries for this incredibly delicious pie. —Kathy Jones, West Winfield, New York View Recipe Raspberry Pie with Oat Crust Raspberry Pie with Oat Crust A diabetic for 30 years, I adapted this recipe to fit my needs. When I serve this pie, no one can believe it's sugarless. The oatmeal crust is so tender...and the filly is berry delicious! —Ginny Arandas of Greensburg, Pennsylvania View Recipe Raspberry Ribbon Pie Raspberry Ribbon Pie While he was growing up, this was my husband's favorite Christmas dessert. When we married, his mother passed it on to me. I take it to family gatherings during the holidays and have yet had any to bring home! It's a cool recipe for summer as well. —Victoria Newman, Antelope, California View Recipe Blueberry Raspberry Pie Blueberry Raspberry Pie Field editor Earlene Ertelt of Woodburn, Oregon shared this lovely fruity dessert that tastes like summer. She notes, "This is one of the very best pies I have ever made." View Recipe Chocolate-Raspberry Mousse Pie Chocolate-Raspberry Mousse Pie Many years ago I found a recipe for a raspberry mousse and played with it to make it lighter. I just love the combination of raspberries and chocolate. —Virginia Anthony, Jacksonville, Florida View Recipe Raspberry Peach Pie Raspberry Peach Pie I came up with this recipe when we had a bumper crop of raspberries, and a friend gave me some of the juiciest peaches we'd ever tasted. —Jean Boelsma, Bethel, Maine View Recipe Glazed Raspberry Pie Glazed Raspberry Pie This tart and creamy treat is shared by Gillian Batchelor of Crescent Valley. "The recipe has been passed down in my family and copied for countless people over the years," Gillian remarks. "There's no mistaking that raspberries give this tall pie its good looks and divine flavor. View Recipe Previous Page ... 4 5 6 ... 7 Next Page Advertise with us ADVERTISEMENT Advertise with us ADVERTISEMENT


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Mary Mary's Erica Campbell Welcomes a Son
Congratulations to Erica Campbell (left) of the Grammy Award-winning gospel team Mary Mary. Campbell gave birth to a baby boy on Sunday, April 24th, just four days before her own birthday. Campbell and her producer husband named their new bundle of joy, Warryn Campbell III...
Read More
Latest News


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2009-04-21 at 11:46:33 am #21928
Applied DNA Sciences Secures Laser Toners
BROOK, NY — 04/09 — Applied DNA Sciences, Inc., a provider of
DNA-based security solutions, announced today that it has developed a
patent-pending system to help mitigate loss of revenue, product recalls
and compromised warranties caused by toxic supply chains. It has
previously filed a patent to cover its proprietary system and methods
for secure document printing and detection of cartridges and laser
that have been counterfeited or diverted to a secondary, grey market.
Schofield, Schofield Imaging Associates, "Fighting back against
counterfeiters is a win-win situation for manufacturers, businesses and
ultimately the consumer. By protecting the toner and the cartridge
itself with DNA, you have a much better chance of authenticating a
genuine product from a fake. This makes it an ideal solution for
protecting brand integrity and performance in commercial and consumer
SigNature® DNA is infinitely
variable. Specific DNA sequences can be used to mark the outside of the
toner cartridge or the toner powder itself.
– Limits the infiltration of illegal toners into re-manufactured
cartridges – Imaging Supplies Coalition estimates that fake ink and toner
cartridges resulted in a $2 billion loss to its member companies in 2003
(including Brother, Canon, Epson, Hewlett-Packard, Samsung, Lexmark, Oki
Data, Sharp Electronics, Toshiba, and Xerox).
– Securing the Cartridge – use security marks with DNA on the outside of
the cartridge to help prevent illegally re-manufactured cartridges from
entering the marketplace.
– Help Protect Printer Devices – against the use of illegal cartridges
that force repairs and invalidate warranties.
– Enhance Safeguarding of Retailers and Manufacturers – against the
infiltration of illegal cartridges into the supply chain.
– Empowering Consumers, Corporations, and Governments alike – to print
secure documents that can be traced to a single, specific toner cartridge.
Benjamin Liang, Chief Technology Officer, stated, "SigNature DNA
persists in toner ink and also after it is printed on paper. It does
not alter the quality of the ink or printed material. We can
authenticate our DNA from laser ink in a non-destructive manner."
SigNature DNA in Laser Printed Documents
the dawn of the information age came the ability to duplicate, change,
alter and distribute virtually any printed document at little or no
cost. Measures to defend against counterfeited documents are being
taken by many corporations, but until now, there has been no
comprehensive, systematic and cost effective solution to prevent
counterfeiting or diversion."DNA can be used to provide a singular
identifier that can be used to mark extremely valuable documents,"
stated Dr. James Hayward, CEO, APDN. "With DNA in laser toner, a
conventional printer can now be used as an affordable method to print
any secure document. Wills, stock certificates, birth certificates, and
even official government documents such as social security cards can
benefit from DNA."
Portfolio of DNA Security Inks
invention extends APDN's growing body of work in the protection of
secure documents and expands upon its successes with security inks,
including: intaglio, inkjet, thermal transfer, UV-curable, screen
printed, flexographic and offset printed inks.APDN is soliciting
commercial partners and will officially unveil its Signature DNA in
Toner success at IMI's 12th Annual Toner Conference in Phoenix,
Arizona, May 4-6, 2009, and 20th Annual Thermal Conference in Orlando,
Florida, May 11-13, 2009 (www.imiconf.com).
About APDN
sells patented DNA security solutions to protect products, brands and
intellectual property from counterfeiting and diversion. SigNature DNA
is a botanical mark used to authenticate products in a unique manner
that essentially cannot be copied. APDN also provides BioMaterial
GenoTyping(TM) by detecting genomic DNA in natural materials to
authenticate finished products. Both technologies protect brands and
products in a wide range of industries and provide a forensic chain of
evidence that can be used to prosecute perpetrators. To learn more, go
to http://www.adnas.com.


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What is JotForm?
JotForm is a free online form builder which helps you create online forms without writing a single line of code. No sign-up required.
At JotForm, we want to make sure that you're getting the online form builder help that you need. Our friendly customer support team is available 24/7.
We believe that if one user has a question, there could be more users who may have the same question. This is why many of our support forum threads are public and available to be searched and viewed. If you'd like help immediately, feel free to search for a similar question, or submit your question or concern.
No Matter what I do Forms don't submit they hang on Please waitAsked by ereputation on May 21, 2014 at 03:23 PM
I've tried every combination of secure form not secure. Taking off required etc. I've read alot of people have this problem. Does not seem like its been solved please help
JotForm Founder
Just submitted your form with no problems. We had a data replication problem. That might be the reason.
But, the mouse signature page was not working. There were no pad to sign. So, maybe you want to open a new ticket about that.
I still can't get it to succesfully submit. Nor can my clients. I also never recieved a notification from your submission are you sure it went through? Also did you use the link I provided or did you use the jotform link?
By the way. Jotform Rocks. Can do amazing stuff without Programming knowledge
Hi ereputation,
It's true that Sir aytekin said.It works fine with the jotform link Form but It doesn't work from your website.I checked both Firefox and Chrome browsers but both results is same.It's the problem only from your website.
So I recommended you to kindly re-embed the source code and normally you may use Iframe code for better response.
See the following link-
For futher assistance in this query,please get back to us.
Thank !


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This non-smoking hotel provides an ideal venue for the business traveller and tourist alike. The hotel offers 45 rooms in total, as well as a quiet and peaceful atmosphere in comfortable surroundings and a versatile conference and banqueting room. The contemporary lounge bar offers a wide range of fine wines, spirits, beers and cocktails. Guests are welcomed into a reception hall with 24-hour check-in service. Facilities include a restaurant, WLAN Internet access and room service.
The hotel is ideally located just off the A90, which is the main route connecting the airport to the city centre. It is just 4.8 km west of Aberdeen city centre. Aberdeen Airport is about 11 km away (a 10-minute drive).
The hotel has 23 standard rooms and 22 suites with contemporary open-plan living space. They are all equipped with the latest home entertainment systems and private bathrooms. Selected rooms offer views across the Grampian region and sea views on a clear day. The rooms are designed with a bright, relaxing d�cor and a modern sense of comfort, and each one comes equipped with a mini fridge, tea and coffee making facilities and plasma-screen TV featuring movie channels free of charge. Other amenities include hairdryer, direct dial telephone and central heating.
The modern stylish Bistro conservatory restaurant offers a wide range of dishes, whether it is a light lunch, high tea or fine dinning. Breakfast, lunch, tea and dinner are available on room service as well.
This hotel accepts MasterCard and VISA as methods of payment.
Start out at Aberdeen Airport. At the roundabout take the first exit onto Argyll Road (signposted Long Stay Car Park 2). At the traffic signals turn left onto Dyce Drive (signposted Aberdeen, Inverness, Dyce). At the traffic signals continue forward (signposted Aberdeen, Inverness). At roundabout take the first exit onto the A96 (signposted Aberdeen). Continue forward onto the A96. Enter Bucksburn. At the roundabout take the second exit onto the A96 Travelodge. At the roundabout take the second exit onto the A96 (signposted Aberdeen). Continue forward onto Auchmill Road - A96. Enter Aberdeen. At the roundabout take the third exit onto the A90 (signposted Dundee, Perth). At the roundabout take the second exit onto North Anderson Drive - A90. At the roundabout take the third exit onto the A90 (signposted Dundee, Perth). At the traffic signals turn right onto Lang Stracht - A944 (not shown; signposted Mastrick Ind Est, Woodend Hospital). Turn left onto Summerhill Road. Then turn left onto Summerhill Drive to reach the hotel.
Check-in is from 2 p.m. Guests should check out by 12 noon on their day of departure.
Room Facilities:
Direct dial telephone
Satellite cable TV
Mini fridge
Tea Coffee
Central heating


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Baseball's Top Performers Of April 2012
Two weeks into the baseball season and already tons to discuss. I always state that at this early juncture the sample size is too small to make meaningful conclusions, i.e look at Josh Willingham's .419/.514/.871 stat line.
Having said that, my friends usually don't miss an opportunity to harp on me and state that they are still putting up these numbers, no matter if they've only had 30 at-bats. So going in this direction, I will discuss some of the big standouts from the first two weeks of the baseball season, even if the sample size is too small.
Matt Kemp, Los Angeles Dodgers
Looks like Kemp is wasting no time attempting to fulfill his prediction of a 50/50 season. He is the driving force behind the Dodgers 9-1 record, mashing six balls out of the park. On the steals front he only has one but that is largely due to the fact that 9 of his 19 hits have been for extra bases. He is hitting .487 with an OPS of 1.549 on the young season; even if he hits half as well for the remainder of the season, the Dodgers could turn some heads in the NL West.
Kemp is drilling the ball, there is no doubt about it, but he has done it against some of the easiest competition possible, the Padres, Pirates and Padres again. It'll be interesting to see how Kemp does in the near future, but for now he is a top fantasy player and as close to untouchable as you can get. Kemp is a player that is supposed to do well, now lets look at players who are outperforming their career averages and may have gained some trade value.
3 More April All-Stars AFTER the jump!
Chris Young, Arizona Diamondbacks
Young is a career .241 hitter and never batted higher than .257, but this year has started out on a .364 clip. Obviously expect regression, which is why now is a good time to put him on the trading block. For fantasy managers who are resistant to the idea, it is possible this year he could be righting the ship. He is 28 years old, coming into his prime and to start the season has walked 6 times compared to 5 strikeouts. Which is definitely a good sign for a player who strikes out 150 times a season.
Omar Infante, Miami Marlins
Infante seems destined to pick up the slack of slumping teaming Giancarlo (formerly known as Mike) Stanton. Infante has hit four homers to date… His home run totals for the past five years (starting in 07') are: 2, 3, 2, 8, 7. I doubt he will keep up what he is on pace to do but that is me being a fan of small sample size again. He could hit 72 homers, which is what he is on pace to do.
Edwin Encarnacion, Toronto Blue Jays
Encarnacion has exceled this year hitting in the middle of the Jays lineup. EE a notoriously streaky hitter has put a good start to what hopes to be a promising season. His slash looks good: .289/.325/.632 and it is not too inflated, except that slugging. Critics love to rag on EE's underutilization of power, which most believe to be mid-to-high 20's. Last year he had only 17 homers, but Jays fans will be hoping for near 30 this year, and with his start one can hope.
All fantasy managers will have different valuations for these players, but if you think that they are overvalued by your league, then why not attempt to get something more sustainable in return. If you think they are going to stay on the same course as they've started out, then you are in for a very nice year.


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admin's blog
3 Lessons Learned from Freeing 3 American Hikers: From Integrity to Engagement to Relationship-based Fundraising
Understanding the Value of Your Social Media Influencers
This post was originally published on Blackbaud's site and was also shared on the TechSoup.org blog.
By: Nicole McGougan
Blackbaud produced a new whitepaper in partnership with SmallAct and the National Wildlife Federation identifying social media supporters and categorizing them into four segments:
What is Open Source? Part 3: Linux
By: Colin McGregor
Imagine Canada National Summit: The Social Media Story
By: Marnie Grona, Director of Marketing & Communications, Imagine Canada
En français - Sommet des OSBL : l'histoire des médias sociaux
Tell Us About Your Technology / Parlez-nous de vos technologies
We want to learn more about how your organization uses traditional and cloud-based technology and about your plans for the future.
Tag, You're IT! An Introduction for Technical Managers
By: Grant Howe, VP of Research & Development, Sage North America's Nonprofit Solutions
Volunteering in the Cloud
By: Cara Hicks, Girl Guide Leader/Brown Owl for 119th Ottawa Brownies, and Blogger at www.browniesmeet.wordpress.com
The Human Cloud: How technology adoption is changing the workforce
By: Noorin Ladhani, Platformation Testing Coordinator, Framework


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Feb 16, 2012
All Creatures Live From Their Hearts
I know it is our brains that tell us what to do, but we choose to refer to the great pumping organ which delivers blood and its life-giving oxygen to our individual cells as the true life force.
Sue Falkner-Wood
Chronic Pain Blog
Life with Chronic Pain: A How-to Guide
Feb 9, 2012
Renewal in a Life of Chronic Pain: Truisms to Live By
Ask anyone who has lived a daily life with chronic pain, and they will tell you cats aren't the only creatures with nine lives.
Feb 2, 2012
Johnny Cash and the Energizer Bunny
I can feel your minds buzzing and some of you saying, "This is it. She's finally gone 'round the proverbial bend." I will attempt to explain to you, my fellow chronic pain sufferers, what is twirling around in my brain.
Jan 19, 2012
Just Keep Your Nose Above the Waterline
Is it possible life is designed like water? Is it possibly buoyant? We often get so caught up in the pain, the suffering, and our problems that we forget life truly wants us to float.
Jan 12, 2012
How Sweet It Is!
We've been receiving candy catalogs lately filled with chocolates that are dark, sour, creamy, and nutty. I would say that's a fairly accurate analysis of life in general — sweet, dark, sometimes creamy, and always nutty.
Jan 5, 2012
How Much Can You Take in This Life of Chronic Pain?
I know this isn't a contest, this pain-filled life, but there are times it certainly feels like it. Two days ago, I definitely came in last in this macabre race.
Dec 29, 2011
How to Have a Happy New Year in Spite of a Life With Chronic Pain
It's so easy to panic in tough times and to worry. Since that's the last thing we need when we live with chronic pain, let's just step back and take a look at the situation.
Dec 15, 2011
The Blessing of the Christmas Quilt
My husband's dear Aunt Ruthie gave me the three oldest quilts I have when she discovered my passion for them. I often touch the them and wonder. Most of them were worked on all year long and saved for Christmas gifts. I...
Dec 8, 2011
Finding the Heart to Live With Chronic Pain
This life with chronic pain is not a simple one. It encompasses lifting a large bucket of problems, doesn't it? Most of us grow desperate looking for answers outside ourselves when the truth is hiding from us, deep within...


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Use the same product and organization you identified in your Week 3 Strategy and Positioning Analysis.
Develop a 2,100-word analysis that includes:
- Describe how your marketing efforts and marketing mix will change with each phase in the product life cycle
- Explain how the packaging you will use for your product or service will add value.
- Analyze the appropriate pricing strategy for your product or service and the price you will set at launch.
- Evaluate the channels of distribution you will use to sell your product along with a description of how each channel partner will add value.
Include at least four sources of research that support your analysis; at least one must be the textbook, one from the University of Phoenix library, and one piece of secondary research.
Format your assignment consistent with APA guidelines
FedEx helicopters parcel delivery
body preview (0 words)
file1.docx preview (2377 words)
Running head: xxxxx xxxxxxxxxxx PARCEL xxxxxxxxxx
Fedex Helicopters xxxxxx xxxxxxxx
Student xxxx
xxx Date
xxxxxxx Name
Fedex xxxxxxxxxxx Parcel xxxxxxxx
Densely xxxxxxxxx xxxxx xxx essential xxxxxxxxxx and economic xxxxxxxx xxxxxxx that generate large xxxxxxxxx xx xxxxxxxxx and density. xxxxxxxx xxxxxxxxxxxx xxx xxxxxxxx xxxxxxxxx xxxxxxxx xx the urban xxxxxxx can be xxxxx xxxx xxxxxxxxxxxx xxx to infrastructure xxxxxxxxxx xxx external xxxxx associated with xxxxx xx a xxxxxxx xxxxxxxxxxxx xx xxxxx in xxx centers xx characterized by high xxxxxx Congestion due to limited xxxxxxxxxxxxxx availability is xxx xxxxx xxxxxxx of the xxxxxxxx xxxxxx This may xxxx delivery xxxxxxxx in xxx centers xxxx to xxxxxxx its xxxxx effectively and efficiently. FedEx has xxxxxxx to xxxxxxx x xxx xxxxxxx to deal xxxx this issue. The xxxxxxx xxxx xxx xxxxxx xxxxxxxxxx flying xxxxxxxxxxx xxx xxx xxxxxxxxxxxx xx parcels xxxxxxxx xx the homes and xxxxxxx xx xxx densely populated areas.
- - - more text follows - - -
Try it before you buy it


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Lancer Labels Ltd
Suite 11, Liberty House
The Enterprise Centre
Greenham Business Park
Tel: 01256 636 436
Product Highlights
Printers: Lancer Labels supplies a complete range of thermal labels printers to cover a wide variety of applications. We only ever select the best systems from leading manufacturers who stand for quality, innovation and efficiency. With us you can be sure you're getting a reliable, fit-for-purpose product. Printer varieties include: Thermal Transfer Labels- Thermal Direct Labels - Medical Printers - Brady Printers - Labelling Systems
Lancer Labels is one of the UK's leading suppliers of self-adhesive thermal labels, and can provide labelling solutions for a wide range of applications. As well as a broad selection of standard stock labels, we can also offer specialist pharmacy labels and customised labels made to specification. A huge range of sizes are available.
We are Lancer Labels Ltd; we provide thermal labels and thermal labelling solutions for a variety of commercial and industrial applications. Whether you need label suppliers for an existing device or a brand new thermal labelling system, we can provide a high quality cost effective solution. In order to cater for the wide and varied needs of our customers, Lancer labels stocks a huge range of self-adhesive thermal labels, barcodes and thermal ribbons, plus a great selection of thermal transfer labels printers, barcode scanners and complete labelling systems, not forgetting our Specialist Wash Care Labelling range too. If you would like any assistance in choosing the right type of labels for your application, please do not hesitate to call.
Our expert advisors are available on 01256 636436
20.03.17 1500
Lancer Labels Ltd, Suite 11, Liberty House, The Enterprise Centre, Greenham Business Park, Newbury, Berkshire, RG19 6HS
Tel: 01256 636 436 Email: email@example.com


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COLUMBUS -- State officials are mourning the passing of astronaut and former U.S. Sen. John Glenn, praising his public service, his longtime marriage to his wife, Annie, and the example he set for others in his home state and nation.
Glenn died Thursday at the age of 95 following an undisclosed illness.
Gov. John Kasich said in a released statement that Glenn was "Ohio's ultimate hometown hero."
"As we bow our heads and share our grief with his beloved wife, Annie, we must also turn to the skies, to salute his remarkable journeys and his long years of service to our state and nation," he said. "Though he soared deep into space and to the heights of Capitol Hill, his heart never strayed from his steadfast Ohio roots."
Attorney General Mike DeWine recounted sitting in his high school science class, watching as Glenn became the first American to orbit the planet.
"That day, he captured the hearts of Americans and guaranteed his place in the history of this country and in the history of the world," he said in a released statement.
DeWine ran unsuccessfully against Glenn for the U.S. Senate, then later served alongside him in the after winning Ohio's other Senate seat.
"No matter where he travelled in the United States, across the world or even into outer space, Sen. Glenn was always proud to call New Concord, Ohio, home," DeWine said. "He met the love of his life, Annie, there in New Concord when they were toddlers. Their 73-year marriage is an inspiration to us all."
Secretary of State Jon Husted said Glenn was "an Ohio-made American hero and a global inspiration."
Husted added in a statement, "He left a legacy of greatness that goes beyond his status as the first American to orbit the earth; he was a dedicated marine, a strong statesman, and a devoted husband and father."
Senate President Keith Faber (R-Celina) asked for a moment of silence on the floor of the Ohio Senate Thursday after news of his death began to spread.
Lawmakers earlier this year renamed the Port Columbus International Airport as the John Glenn Columbus International Airport.
"His service forever shaped America, forever shaped Ohio and pushed us forward," Faber said. "We will mourn his loss, honor his legacy and forever remember the words that sent him on his next mission toward the heavens -- Godspeed, John Glenn."
House Speaker Cliff Rosenberger (R-Clarksville) called Glenn a "hero of mine, a mentor in my life and a man whom I look up to for not only his admirable career, but his steady morals, unmatchable character and his love of family."
He added in a released statement, "I've spent a lot of time with John and Annie, and my thoughts and my sincere prayers are with her and the rest of their wonderful family during this very difficult time. Today, we have lost a great man who has left a truly lasting, impactful legacy on this state, the nation and the entire world."
Democratic Sen. Sherrod Brown said in a statement that knowing Glenn was "one of the great blessings of my life."
"What made John Glenn a great senator was the same quality that made him a great astronaut and an iconic American hero: He saw enormous untapped potential in the nation he loved and he had faith that America could overcome any challenge," Brown said. "John's kindness, his intelligence, his courage and his commitment to service set an example that our country needs today more than ever. John's legacy will live on in the pages of the history books and the hearts of everyone who knew and loved him."
Republican Sen. Rob Portman offered similar sentiments in a statement.
"John Glenn was an American hero," he said. "He flew 149 combat missions in two wars; he was the first American to orbit the Earth, and the longest-serving United States Senator in Ohio history. I'm grateful to have known him, to have partnered with him on projects and legislation in Congress, and to have worked with him and served on his advisory board at the John Glenn College of Public Affairs at the Ohio State University. Most recently, I called him to ask him to join me at my swearing in in January for the seat he once held. When I saw Sen. Glenn in October at the Glenn School board meeting he was in good humor, gracious and determined to contribute to Ohio, as always. John and Annie's marriage and their seven decades of partnership have been a model for Jane and me, and we send our condolences to our friend Annie and all the Glenn family at this difficult time."
Ohio Senate Minority Leader Joe Schiavoni said in a statement that Glenn "did it all. John Glenn was fearless. His resume of groundbreaking achievements spans three quarters of a century. Americans may not know that John Glenn requested and flew 59 combat missions in World War II, and 63 more in the Korean War. They may not know he set the 1957 speed record, flying from Los Angeles to New York in three hours and 23 minutes."
He added, " Our nation celebrates John Glenn as the first American to orbit the Earth. They remember him as a great senator from the state of Ohio, who fought tirelessly for the people of our state. Never satisfied, Sen. Glenn also later became the oldest person to go into space."
Ohio State University houses the John Glenn College of Public Affair and the John Glenn Institute of Public Service and Public Policy.
OSU President Michael V. Drake offered in a released statement, "Sen. Glenn was a decorated U.S. Marine aviator, legendary NASA astronaut, tireless public servant and an unparalleled supporter of the John Glenn College of Public Affairs at Ohio State, where he served actively as an adjunct professor until just recently. He was an authentic hero whose courage, integrity, sacrifice and achievements inspired people, young and old, around the world."
He added, "Most importantly, he was a loving husband, father and grandfather. He and his wife, Annie, have been the definition of model citizens. Meeting them was among life's greatest privileges. Spending time with them was a blessing."
Memorial services for Glenn are being planned.
Marc Kovac is the Dix capital bureau chief. Email him at email@example.com or on Twitter at OhioCapitalBlog.


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Plan your visit to see any of the current exhibitions by viewing location, transport, and facilities information here.
1916 Portraits and Lives
13 May – 31 October 2016
The biographies selected compose an inclusively broad picture of the rising, representing the spectrum of personalities and perspectives that were involved in the event. They include not only the insurgents (and some others) killed during the rising but also some of the women who were involved as soldiers or in supporting capacities; three nationalist leaders who opposed the rising; some of the senior figures in the British administration in Ireland in 1916; members of the British army that suppressed the rising; and two historians who made considerable contributions to the scholarly debate on 1916. This selection aims to give a balanced view of the rising.
Future Histories
21st May 2016
Niamh Murphy and Áine Phillips will curate a 12-hour live art and video event with 16 acclaimed Irish artists at Kilmainham Gaol to respond to its iconic historical associations with the 1916 Rising. The invited artists, from north and south of the border, who work in performance, live art and video will respond to the 1916 centenary, creating contemporary perspectives on our shared past, conflicts, crises and passions in relation to the Rising and its greatest monument, Kilmainham Gaol.
The artists are Amanda Coogan, Danny McCarthy, Brian Connolly, Debbie Guinnane, Helena Walsh, Sandra Johnson, Fergus Byrne, Francis Fay, Katherine Nolan, Pauline Cummins, Ciara McKeon, Dominic Thorpe, Méabh Redmond, Dr. Laura McAtackney, Michelle Browne, Alastair McLennan and Sinéad O'Donnell.
Kilmainham Gaol Museum Permanent Exhibition
The main exhibition at Kilmainham Gaol Museum tells the story of the social and political history of the prison. Three main themes are explored on three levels of the exhibition space:
- social history of Kilmainham Gaol and Irish prisons in the 1800s
- the history of Irish nationalism and republicanism, 1796-1924
- the restoration of Kilmainham Gaol in the 1960s
The ground floor exhibition tells the story of Kilmainham Gaol from the perspective of the ordinary prisoner. A prison register for Kilmainham Gaol shows the crimes for which men, women and children were imprisoned, ranging from violent assault to stealing apples from an orchard. Visitors can see the small wooden box used by convict John Sheahan to carry his possessions to Australia in 1842. A Victorian-era Gandolfi camera, used to capture prisoner 'mugshots', is also on display.
Rebellion, nationalism and the path to independence are the themes of the exhibition on the first floor, which deals with Irish political history from the 1798 rebellion up until the end of the Irish Civil War in 1924. Objects on display include Robert Emmet's proclamation of a provisional government of Ireland in 1803, the last letter written by Charles Stewart Parnell and scapulars taken from the body of Michael Collins following his assassination in 1922.
The 'Last Words' section of this exhibition displays the last letters and personal belongings of the fourteen leaders of the Easter Rising executed at Kilmainham Gaol in May 1916.The final floor of the exhibition tells the extraordinary story of a group of volunteers who rescued Kilmainham Gaol from near ruin in the 1960s and restored it as a monument dedicated to the men and women who were imprisoned or executed in Kilmainham Gaol in the cause of Irish independence.


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C-Clown Sells Out Tickets for Upcoming Japanese Solo Concert
C-Clown sold out all tickets for its Japanese concert scheduled for June.
Yedang Entertainment, C-Clown's agency, announced on May 2, "C-Clown sold out tickets for Live Event in Japan AiiA Theatre Concert."
After selling out tickets for two rounds of 'Live Arch' concerts that took place in 2013, C-Clown sold out tickets this year as well, becoming a new hallyu group.
The upcoming concert will especially involve interaction with the fans as it will feature a talk concert between the members and the fans among many other programs. C-Clown previously performed in Yokohama last August for K-Fest Summer! 2013 in Yokohama, catching many Japanese fans' attention.
The group was later invited to perform as special guest for Japan's grand sized K-pop concert Live Arch, selling out all tickets and receiving numerous love calls from record and show-hosting companies around Asia.
Yedang entertainment stated, "C-Clown is already rising as a new hallyu group in Japan through various performances. We realized C-Clown's popularity when the tickets were sold out immediately, without any special promotions."
An affiliate of C-Clown's Japanese concert said, "C-Clown's unique charms and superb looks are more than enough to capture the hearts of Japanese fans. Their popularity in Japan will only increase over time."
Meanwhile, C-Clown is planning to hold a concert tour in China and South America after performing in Live Event in Japan AiiA Theatre Concert on June 21.
Photo credit: Yedang Entertainment


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Willie Mays
May 6, 2011 by staff
Willie Mays, A trip to New York in January gave the San Francisco Giants Buster Posey recipient the opportunity to spend time with Willie Mays, who joined a delegation of the team in the World Series trophy to the birthplace of the club.
Pose for the experience was similar to time travel through the history of the game with Mays as a tour guide did not learn from books, but from experience.
"It's almost like, if you were lucky enough to sit and talk to Babe Ruth when he was alive, or Mickey Mantle or (Joe) DiMaggio," Posey said, highlighting Mays wit and enduring passion for the game. "He is a living legend."
The legend turns 80 today, and the Giants will mark the occasion with a pregame ceremony that included tributes to some of his former teammates with the Birmingham Barons of the American black Black League.
That was the team that Mays made his professional debut as a high school student aged 17 in 1948, three years before he became Rookie of the Year with the New York Giants.
He is one of the four livings Hall of Famer who played in the Negro Leagues, along with Hank Aaron, Ernie Banks and Monte Irvin, and it evokes back some of the signature moments of the game.
Mays was the batter on deck when Bobby Thomson hit "Round shot heard the world", sending the Giants 1951 World Series, and his immortal catch of Vic Wertz drive in the 1954 Fall Classic has been considered one of the great works of history.
The film legends: Willie Mays, which premieres Sunday on Comcast SportsNet Bay Area, not only highlights remarkable physical skills Mays, but his baseball acumen.
"He was like a coach on the field," said his companion, long and fellow Hall of Famer Willie McCovey in the film. "I knew beforehand what would happen."
Yet, Mays makes a startling confession in the documentary about Thomson's iconic home run.
"I knew that the game was over,"he said." I am the last to dish (for holding). "
In retirement, Mays has remained connected to the game as an ambassador for the Giants and the godfather and confidant of Barry Bonds, who in 2007 set baseball's home run record of all time.
Bonds name thrown into the discussion of the greatest players the game but for players of Mays' era – seen as a golden era in baseball – there's not much to discuss.
"Barry Bonds was a tremendous ballplayer," said Hall of Famer Orlando Cepeda, a Bay Area resident who frequently attends Giants games and was a teammate of Mays from 1.958 to 1.966. "But nobody can be compared to Willie Mays. There is nobody like Willie Mays."
Four years before he joined and roomed with the Giants in Cepeda's rookie season of 1958, El Torito was a batboy for Mays team winter league in Puerto Rico, Santurce Crabbers.
Mays were coming off a season NL MVP and a World Series championship, but he went to winter ball to earn some extra money. Cepeda was in awe.
"It was the most valuable player and is playing every game in Puerto Rico as if the World Series,"said Cepeda." And he did not sit any games."
Ray Doswell, curator of the Negro Leagues Museum in Kansas City, said winter ball always one of the few opportunities before 1947 for players of all colors to play together.
Once Jackie Robinson broke the color barrier, his outstanding work and success of players like Roy Campanella, Larry Doby, Don Newcombe and Mays paved the way for future black players, Doswell said.
"When you look at players like Mays and even the other young players who came after him,"said Doswell," far from black and Latino players, this is the consummation of his greatness."
Mays nearly four decades playing days, they still marvel at the greatness.
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|1,600 sq. ft.
|Property type
|Minimum Stay
|3 nights
This beautiful complex has an ocean view from all their condos, it's a private complex, so there is a security gate at the entrance to be sure only owners and guests are allowed to enter.
This condo is near everything, is minutes away from stores like walmart, soriana, comercial mexicana chedraui even there is a costco not far away, so you have a well supplied vacation.
It has a beautiful garden with charcoal grill where you can spend a great evening grilling your own steaks or fish very close to the pool for the recreation of the whole family, beautiful sunsets when you are relaxing by the pool.
The swimming pool is very big and nice not as crowded as in an hotel, as you can see in the pictures.
The condo has everything you need, and more to get an amazing and affordable vacation.
You can contact me at my cell phone at any hour,(52)811-812-1288 if you have a smartphone you can reach me with whatsapp.
1. How far is from the airport?
A: Well distance is around 23 km, but there is several transportation services for you depending the people in your party.
2. We need to rent a car?
A: It's not like you are not going to enjoy Cancun if you don't have a car, but is strongly suggested, and can help you to save money in tours, and you can get more time to enjoy the parks in Cancun with your own transportation.
3. Is there a convenient store close to the condo to buy groceries?
A: Yes, crossing the street from the main entrance is a small store called Extra is kind of a Seven Eleven kind of store.
4. How far is from the main hotel zone?
A: Is like a 5 minutes drive.
Owner managed no comission fees, no administration charges or something like that, as the rental company charges.
Beautiful and well keep condominium! We enjoyed our stay here. Short distance to hotel zone and activities. Pool is very nice. Beach had a lot of seaweed but a tropical storm came through a the beginning of our stay .....so that may have been the reason. Ivan was receptive and responsive to questions.
Our family stayed in Cancun for a week in October and we had a great time. The place was very secured and well kept. We had a minor issue with the air conditioners but as soon as we called Ivan he sent someone out to fix it. The view from the condo was absolutely beautiful. The pool was awesome and there is a little playground for your little ones. It is about a 10 min car ride to the hotel/tourist area. I would definitely recommend staying here. Thanks again Ivan!
The Amara condo is a well-equipped and easily acessible apartment. With only two people staying, we had plenty of space. The rooms are air-conditioned individually and operate very quietly when on. Ceiling fans are an alternative. The place is clean, but renters need to be prepared to bring/buy basic necessities such as sugar and coffee to fill immediate needs.
The complex consists of two buildings, overlooking a well-maintained garden, with common birds and iguanas. It is only a short walk to the swimming pool. Its nicest feature is a slowly deepening slope, providing a shallow pool for small children as well as easy access to the main pool for the elderly.
To top it off, a friendly pavilion restaurant offers a simple menu for a relaxing meal, overlooking the pool and the garden.
All is well-maintained. For those who choose to stay away from the Zona Hotelera, the Amara is an excellent alternative. We chose to rent a car to get around, an excellent solution in our case.
The condo was beautiful. The only problem I had was the water bugs and the ants. The air conditioning kept dripping water and on my way home I found a huge water bug in my purse. How embarrassing. The pool was beautiful and large. The beach was rocky and alot of seaweeds. And the was a lady from security thats very rude. I would recommend if u go to make sure the owner gets the condo exterminated before u arrive.
Mi familia y yo queremos darle nuestro mas sincero agradecimiento al señor Iván por permitirnos alojarnos en su hermoso apartamento del 20 al 26 de Junio 2016.
Todo fue espectacular las instalaciones del condominio son muy limpias, organizadas y lo mas hermoso las Iguanas que al igual que todo el personal eran muy agradables con los visitantes.
La piscina es muy segura para los niños ya que puedes disfrutar de la misma sin ningún inconveniente y contar con una hermosa vista al mar.
El sector para nosotros fue perfecto ya que a pesar de que esta retirado de la zona hotelera es un sitio muy tranquilo y de fácil acceso a todos los lugares, para ir a Isla Mujeres lo puedes hacer sin problema ya que la estación del ferry esta a solo 5 minutos.
Nosotros tuvimos la oportunidad de rentar un vehículo el cual nos pareció muy económico y en realidad puedes salir a todos lados sin inconvenientes ya que Cancún es una ciudad que cuenta con muy buena señalización de ubicación, créeme no se pierde uno en la ciudad.
El apartamento cuenta con todas las comodidades camas muy confortables, los cuartos con sus aires acondicionados aunque la brisa natural es lo mejor que tiene este apartamento, el señor Ivan es una persona muy amable siempre dispuesta ayudarnos con todas nuestras inquietudes sin importar la hora en que lo necesites.
Señor Iván gracias a usted y al equipo de grandes profesionales con quien cuenta el condominio por habernos permitido pasar unas vacaciones inolvidables.
Victoria E. Ñañez
Overall we had a good experience, Ivan is very hospitable, and the condo is nicely equipped. The view from the deck is great, and location is more private and less crowded than the hotel row. Security presence is massive which is nice. Taxi are close by to get you where you need to go. Negatives well the hot water situation is a little tricky, and the store that is close by is barely a store. Plan ahead and shop before you get there, hindsight that what I wish I had done. Also if you are planning on tours etc. picking you up, some places had a hard time finding us (just fyi). Thank you for the nice stay Ivan
|Cleaning Fee
|Damage Deposit
Check in must be done at 4:00 pm, checkout at 11:00 am. Sometimes we don't have guests arriving or leaving the same day in that case you can arrive or leave at diferent hours.


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Oncogenes and Tumor Suppressor GenesBY: Shalini Balan | Category: Others | Submitted: 2011-11-07 03:57:25
Article Summary: "The production of cancer cells in our body and latest development to suppress or arrest tumor formation..."
A gene that is capable to produce cancer cells when activated. Oncogenes are generally mutated forms of normal cellular genes which are termed as proto-oncogenes. These alterations are usually somatic events, although germ-line mutations can affect a person to heritable cancer.
Proto-oncogenes are a group of genes that cause normal cells to become cancerous when they are mutated. Mutations in proto-oncogenes are typically dominant in nature, and the mutated version of a proto-oncogene is called an oncogene. Often, proto-oncogenes encode proteins that functions to stimulate cell division, inhibit cell differentiation, and stop cell death. All of these processes are important for normal human development and for the maintenance of tissues and organs. Oncogenes, however, typically show increased production of these proteins, thus leading to increased cell division, decreased cell differentiation, and inhibition of cell death; which ultimately leads to the production of cancer cells. Thus, oncogenes are currently a major molecular target for anti-cancer drug design.
Transformation events in cancer have been defined as initiation events or progression events.
Today, more than 40 different human proto-oncogenes are known. But what types of mutations convert these proto-oncogenes into oncogenes ? Oncogenes are forms as a result of mutations that increase activity of a proto-oncogene. Fundamental genetic mechanisms associated with oncogene activation include the following:
• Point mutations, deletions, or insertions that lead to a hyperactive gene product
• Point mutations, deletions, or insertions in the promoter region of a proto-oncogene that lead to increased transcription
• Gene amplification events leading to extra chromosomal copies of a proto-oncogene
• Chromosomal translocation events that relocate a proto-oncogene to a new chromosomal site that leads to higher expression
• Chromosomal translocations that lead to a fusion between a proto-oncogene and a second gene, which produces a fusion protein with oncogenic activity
Mutations are the sudden inheritable change that takes place in the genes. Mutations are gene defects. Mutations involve changes in the arrangement of the bases that make up a gene. Even a change in just one base in the thousands of bases that make up a gene can have a major effect.
A mutation can affect the cell in many ways. Some mutations stop a protein from being made at all. Others may change the protein that is made so that it no longer works the way it should or it may not even work at all. Some mutations may cause a gene to be turned on, and make more of the protein than usual. Some mutations don't have a noticeable effect, but others may lead to a disease. For example, a certain mutation in the gene for hemoglobin causes the disease, sickle cell anemia.
They are usually of two types namely; Hereditary Mutations are gene defects that are passed from a parent to child. Some people are more likely to develop cancer than others simply because they are born with mutations in their genes. Other type is termed as Acquired Mutations. An acquired mutation can be caused by things in the environment such as exposure to radiation or toxins.
It is important to realize that mutations in our cells happen all the time. Usually, the cell detects the change and repairs it. If it can't be repaired, the cell will get a signal telling it to die in a process called apoptosis. But if the cell doesn't die and the mutation is not repaired, it may lead to a person developing cancer.
Genes in the body that can suppress or block the development of cancer and prevent tumour formation. Their protein product inhibits mitosis. A tumor suppressor gene directs the production of a protein that is part of the system that regulates cell division. The tumor suppressor protein plays a role in keeping cell division in check. When mutated, a tumor suppressor gene is unable to do its job, and as a result uncontrolled cell growth may occur. This may contribute to the development of a cancer.
Example 1: RB - the retinoblastoma gene
Retinoblastoma is a cancerous tumor of the retina. It occurs in two forms:
Familial retinoblastoma and Sporadic retinoblastoma
Familial retinoblastoma:
Multiple tumors in the retinas of both eyes occurring in the first weeks of formative years
Familial retinoblastoma occurs when a baby inherits from one of its parents a chromosome (number 13) that has its RB locus deleted or otherwise mutated. The normal Rb protein controls the cell cycle. It integrates the signals reaching the cell to determine whether it is safe for the cell to complete the passage from G1 of the cell cycle to mitosis.
A random mutation of the remaining RB locus in any retinal cells -- which are nondividing cells and should not enter the cell cycle -- completely eradicates the inhibition done by the Rb protein, and the affected cell grows into a tumor. So, in this form of the disease, a germline mutation plus a somatic mutation of the second allele leads to the disease.
Sporadic retinoblastoma:
A single tumor appears in one eye sometime in early childhood before the retina is fully developed and mitosis in it ceases.
In this disease, both inherited RB genes are normal but a single cell suffers s a somatic mutation (often a deletion) in both in order to develop into a tumor. But such cases are very rare .
In both forms of the disease, the patient's life can be saved if the tumor is detected soon enough and the affected eyes are removed.
The discovery and understanding of oncogenes and tumor suppressor genes has led to the development of new kinds of cancer therapies. The following are some examples of genes that are cancer treatment targets.
In some cases of breast cancer, the cells make an excess amount of a protein called HER2/neu. This protein promotes the growth of cancer cells. Cancers with too much of this protein did not respond as well to certain chemotherapy drugs (namely, cyclophosphamide, methotrexate, and fluorouracil), A drug was also designed to specifically attack cells with too much HER2/neu called Trastuzumab (Herceptin®) which sticks to the HER2/neu protein so that the growth of the cancer cells is slowed down. It has already been found to be useful in treating women whose breast cancer cells have abnormalities of this gene and/or its protein. Studies are currently being done to see if it will be useful in treating people with other cancers. Another drug that targets the HER2/neu protein, lapitinib (Tykerb®), is also available and others are being tested in clinical trials.
There are some cancers which returns back or persist even after treatment and at times it becomes hard to detect. For example, in chronic myeloid leukemia (CML), the cancer cells have a gene change that brings the oncogene ABL to a place on another chromosome called BCR. This creates a new gene called, BCR-ABL, that makes a type of protein called a tyrosine kinase. Drugs have been created that target the BCR-ABL protein, killing the leukemia cells. These drugs include imatinib (Gleevec®), dasatinib (Sprycel®), and others. They have led to remission of the leukemia in most patients treated in the early stages of their disease.
Most gastrointestinal stromal tumors are caused by activation of the oncogene called KIT. Others are caused by activation of PDGFRA, another oncogene. The drug imatanib (Gleevec®) targets both of these oncogenes, and is able to shrink these tumors and help patients live longer.
When tumor suppressor gene is used for treating cancer patients have several problems to overcome.
A major stumbling block lies in how to get new DNA into the cancer cells. Another problem is that most cancers have several mutations, so replacing one gene may not be enough to stop the cancer cells from growing and spreading.
Scientists have attempted to treat some cancers that have mutations in the p53 gene by inserting normal p53 genes into viruses and then trying to infect tumor cells with these viruses. Lab tests have shown that the treated viruses can get into the tumor cells and restore the normal p53 gene. These cells then grow more slowly than the other cancer cells. But the overall results were disappointing, and studies of this drug have been stopped.
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