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"The thoughts we choose to think are the tools we use to paint the canvas of our lives."
— Louise L. Hay
— Louise L. Hay
Life is about coping with conflicting demands; balance and calm are often purely aspirational. Periodically, we all need to tune into mind and body; unearth hidden barriers; invite and accept change; learn how to deal with stress; or detect underlying health issues. Alternative therapies such as aromatherapy, bioresonance medicine, body-mind balancing, ear candling, holistic dietetics, massage, reflexology, reiki, or sports therapy massage can deliver very positive outcomes. Why not visit us for a consultation or partake in one of our workshops: our Love Yourself, Heal Your Life® Louise Hay workshop may help you ring the changes you need, or an ear candling, aromatherapy, reiki, or colour workshop could restore harmony and balance into your life. Remember, life's pressures are not age-specfic; they can impede us at any stage in life.
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Whether you are looking for a career change, a better way to deal with life's challenges or just simply have more peace in your life, the Love Yourself, Heal Your Life Teacher Training gives you the opportunity to manifest more of what you want in your life.
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Eileen Clair is a teacher trainer authorised by Hay House, Inc, and approved by Louise Hay.


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- S. D. Bruda, S. G. Akl
- 2006
We show that all the problems solvable by a nondeterministic machine with logarithmic work space (NL) can be solved in real time by a parallel machine, no matter how tight the real-time constraints are. We also show that several other real-time problems are in effect solvable in nondeterministic logarithmic space once their real-time constraints are dropped… (More)
- Stefan D. Bruda, Selim G. Akl
- 2001
- Jianguo Chen, Huijuan Lu, Stefan D. Bruda
- 2009 International Conference on Networks…
- 2009
We developed a model to investigate the phenomenon of whitewashing in peer-to-peer (P2P) systems. A white washer is a node that leaves the network and re-joins using a different identity. Whitewashing is a common problem in P2P systems and is a difficult to manage properly for reputable systems. The paper discusses the definition and properties of trust,… (More)
- Stefan D. Bruda, Yuanqiao Zhang
- Scalable Computing: Practice and Experience
- 2009
We investigate the relative computational power of parallel models with shared memory. Based on feasibility considerations present in the literature, we split these models into " lightweight " and " heavyweight, " and then find that the heavyweight class is strictly more powerful than the lightweight class, as expected. On the other hand, we contradict the… (More)
- Selim G. Akl, Stefan D. Bruda
- Parallel Processing Letters
- 1999
Traditionally, interest in parallel computation centered around the speedup provided by parallel algorithms over their sequential counterparts. In this paper, we ask a diierent type of question: Can parallel computers, due to their speed, do more than simply speed up the solution to a problem? We show that for real-time optimization problems, a parallel… (More)
- Stefan D. Bruda, Selim G. Akl
- 1999
A data-accumulating algorithm (d-algorithm for short) works on an input considered as a virtually endless stream. The computation terminates when all the currently arrived data have been processed before another datum arrives. In this paper, the class of d-algorithms is characterized. It is shown that this class is identical to the class of on-line… (More)
- Stefan D. Bruda, Selim G. Akl
- J. Parallel Distrib. Comput.
- 2001
A correcting algorithm is one that receives an endless stream of corrections to its initial input data and terminates when all the corrections received have been taken into account. We give a characterization of correcting algorithms based on the theory of data{accumulating algorithms. In particular, it is shown that any correcting algorithm exhibits… (More)
- Selim G. Akl, Stefan D. Bruda
- 2000
Parallel computers can do more than simply speed up sequential computations. They are capable of nding solutions that are far better in quality than those obtained by sequential computers. This fact is demonstrated by analyzing sequential and parallel solutions to numerical problems in a real-time paradigm. In this setting, numerical data required to solve… (More)
In the data{accumulating paradigm, the input is an endless stream. A computation is considered to be nished when all the already received data are processed before another datum arrives. We study sorting algorithms in this paradigm. First, we consider the data arrival law as being polynomial in time. We prove the existence of an upper bound on the running… (More)
- Selim G. Akl, Stefan D. Bruda
- 2000
The primary purpose of parallel computation is the fast execution of computational tasks that are too slow to perform sequentially. H o w ever, it was shown recently that a second equally important motivation for using parallel computers exists: Within the paradigm of real-time computation, some classes of problems have the property that a solution to a… (More)

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gtdjewelrynmore on Aug 8, 2015
Thank you so much for the beautiful quilt! It is wonderful. And thank for the the quick response to my original questions.
Terri Creeley on Mar 4, 2015
This is the second in a series of five custom quilts that Vicki is making for the bunk room at our beach house. It is absolutely beautiful and fits the room perfectly. Vicki has been great to work with and has filled my orders much faster than I expected. I'm looking forward to working with her on the rest of the project.
Laura Riley on Sep 23, 2014
Vickie was wonderful to work with! Quick communication and very willing to create the perfect custom order. The resulting quilts are beautiful and very well made. I know we will enjoy them for many years to come!
I've been a quilter and artist for over 10 years. Quilting allows me to express my creativity using fabric as my canvas. I find the ocean to be my greatest source of inspiration and I especially enjoy creating quilts depicting sea-life.
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Sandbox Quilts
I'm a self-taught quilter who began quilting approximately 10 years ago. Quilting gives me an opportunity to combine my artistic talents with my love of fabric. The result is a one-of-a-kind usable piece of art.
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Unfortunately, I am not able to make quilts any larger than a lap or throw size.
To care for a quilt, I recommend using a mild detergent and low tempurature settings.
I am now using onesies from American Apparel. I am very pleased with their product. They are very soft, all-cotton, and well made. If you need a different size, please feel free to ask as I often have larger sizes available.
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We help you search for a Ambleside double bass tutor. Double Bass tuition are a great method to begin a stimulating new hobby, pick up a new talent and gain confidence with double bass. Please use our site to find Ambleside double bass tutors and choose which best suits your needs so you can start your double bass lessons in Ambleside immediately!
This is the best place to discover Ambleside double bass teachers in the UK, helping you discover Ambleside double bass tuition in your area and Ambleside teachers to assist with any instrument like piano, violin or guitar. We can help you find Ambleside double bass tuition or a Ambleside double bass teacher to prepare for double bass grades and improve your double bass skills! Our search will order Ambleside double bass tutors local to you by their hourly charges and proximity to you.
If you are a double bass teacher wishing to offer your double bass lessons in Ambleside or anywhere else across the UK, please register with First Tutors: Music or learn about us here. Becoming a Ambleside double bass teacher is a fantastic way to re-affirm your own knowledge through giving double bass tuition while assisting someone else, all in Ambleside!


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Assad: Atmosphere in the region "positive"
Syria's President Bashar al-Assad on Monday described the general atmosphere in the region as "positive," calling for constantly giving momentum to the current positive course of action.
Meeting Norwegian Foreign Minister Jonas Gahr Store Monday morning, the Syrian leader noted "it is very important to restore the Palestinian national unity as it is difficult to achieve any positive progress without it."
As for Lebanon, al-Assad pointed out to the importance of carrying out Doha Agreement as a whole and forming a national unity government as soon as possible. On Iraq, he reiterated Syria's support to the present political process in the country, indicating that this process should encompass all walks of life and coincide with a timetable for the withdrawal of foreign forces from there.


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This is my first time to create a blog.
Well here it goes.
During the Oracion Seis arc, Wizard Saint Jura Neekis is involved during the fray but he isn't stronger then compared today.
During Grimoire Heart Invasion (Tenrou Arc) it takes the likes of Makarov, Laxus and Gildarts and all FT just to defeat Grimoire Heart.
Now During Tartarus arc, it takes all FT members (with the exception of Gildarts) plus Crime Sorciere (Jellal and Meredy) and Sabertooth (Sting and Rogue; maybe in the future Orga, Rufus and Yukino would join the fray, also hoping the Aguria sisters (Angel and Yukino respecitively) to fight together if Angel would accept his alliance with CS along with his co-Oracion Seis members which most likely they'll accept, they are all wiped by Jellal alone, poor Oracion Seis sob...) to battle Tartarus.
I think Gildarts should comeback to even the playing field against Tartarus.
Hoping for a FT + CS + SBT + LS vs Tartarus
Also looking forward for the Team Natsu Slayers (Gray and Natsu) against E.N.D himself.


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Blood Drive
January 13 @ 9:00 am - 3:00 pm
Event Navigation
Friday, Jan. 13, 9 a.m. to 3 p.m. Cargill Connection Center, 10383 165th Ave. NW, Elk River. American Red Cross Blood Drive. Regular collection (no Power Red collection). Bring photo id or Red Cross card. Walk-ins welcome. Schedule appointments at www.redcrossblood.org (sponsor code Cargill) or call Terry at 763-241-3368.


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Hanging houses of an enchanted city
The beauty and history of Cuenca have earned it a place as a World Heritage Site.MADRID - Cuenca is one of 13 Spanish towns declared World Heritage Cities by UNESCO, a jewel of architecture that preserves examples of its Moorish origins as a stronghold for the Umayyad Caliphate of Córdoba, as well as Christian buildings dating back to the conquest of the city in the 12th century by King Alfonso VIII.
Cuenca boasts Spain's first Gothic cathedral, whose nucleus was built at that time, although subsequent additions throughout the centuries added new styles to the massive building.
However, Cuenca is mostly famous for its "hanging houses" (casas colgadas), which perch precariously atop a narrow gorge over the river Huecar. At one point, the entire rock face was full of such houses, but today only three remain.
They underwent extensive restoration in the 20th century to maintain them in a similar state as that in which they were originally built, with an abundance of wood as building material.
The Puerta de San Juan is one remaining door of the seven or eight gates that gave access to the town when it was still surrounded by a protective wall. Legend has it that King Alfonso VIII entered Cuenca through this door to recover it from the Moors.
This setting is home to one of Spain's most notable Easter celebrations, which in Castilla-La Mancha are usually sober and silent in comparison with the more boisterous Andalusian processions.
Declared of International Tourist Interest, it is the city's most important cultural event of the year, and brotherhoods take care to maintain the spirit of those first processions from the 17th century.
Eerie landscapes
After visiting the myriad churches and noble homes that dot the city, many visitors head out to La Ciudad Encantada (The Enchanted City), a natural space where water erosion has created fantastically shaped stones inside a gorge between the locations of Uña and Villalba de la Sierra. A walk through this eerie landscape takes visitors to stone "sculptures" called The Elephant, The Dog and The Boat.
Around 80 kilometres from Cuenca capital is another natural space of interest, the Nacimiento del Río Cuervo, where the river of that name originates. Water running down from the mountain has created highly original rock formations inside the cave where the Cuervo is "born." To get there one must walk along a mountain trail that follows the course of the river and its many small cascades.
For more natural beauty, the Hoces del Cabriel is a natural reserve with a notable biodiversity that is home to, among other species, otters, wildcats, golden eagles, peregrine falcons and eagle owls.
[El Pais / S. U. / Expatica]
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Hi my friends,
Hope you are having a wonderful day! I surely am as my deadlines are finally over 🙂 🙂 ! The stress goes down the mojo is back! Today I share with you a card I made some months ago for one of my clients. It was meant for a baby shower. I used this baby onesie as template, embossed the little dots by hand (difficult the see in the picture, but they are there) and finally decorated it.
Hope you like it …


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Most Helpful Girl
At one time it could be done but not now. This is under "Help" > "Account":
Can I change my username?
Unfortunately no. Recently we have changed our policy and do not allow username changes anymore. Username changes have been starting to become more and more popular and these changes have been creating confusions among users. So, no more username changes. Thank you for your understanding.10|10|0
thank you


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Answer to question 3. \[\frac{6l-1}{4l-3}=\frac{7k-5}{5k-3}\] After cross multiplication we get \[8k+l+lk=6\] Adding 8 to both sides \[8k+8+l+lk=14\] \[8(k+1)+l(1+k)=14\] \[(8+l)(1+k)=14\] Since \(l,k\) are integers therefore the solutions of \[(l,k)=(-1,1),(-6,6),(6,0),(-7,13),(-15,-3),(-22,-2),(-10,-8),(-9,-15)\] Therefore the required fractions are \[ 1,\frac{43}{31},\frac{5}{3},\frac{37}{27},\frac{13}{9},\frac{19}{13},\frac{61}{43},\frac{55}{39}\]
Group Mathematical Olympiad is conducted by CBSE . It is only for CBSE students . Every CBSE school can send 5 students for it. Around 30 students are selected from the country and are eligible to write INMO.


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GERMANY: VW after 10% cost cut and China buying step-up
Volkswagen plans to cut 10% from its materials costs by 2008 and will sharply step up buying from suppliers in China, the head of purchasing told Reuters.
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French fashion house Chloé was founded in 1952 by Gaby Aghion, who pioneered pret-a-porter. With the likes of...
OnlyLens is an online shop created in 2009. We sale sunglasses guaranteed by the best and most prestigious brands.
More information at www.onlylens.com
Enjoy the sun!
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In the bible story of adam and eve. isn't it all eve's fault humanity got screwed over
Most Helpful Girl
- pr3ttybr0wnmho 18%
Why is it Eve's fault? Adam could have said no.20|20|0
Most Helpful Guy
- fenixx0083mho 6%
No, it was/is all God's fault... evil is inherant in his plan00|00|1
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Satan was part of God's plan
God made him, and he's omniscient and thusly knew Lucifer was going to rebel before he made him, but made him anyway
A normal child's normal parent isn't omniscient
Normally a parent wouldn't be responsible for their children's actions, no... not after they come of age, anyway...
there you go. god give you advise-but doesn't force use to obey them. he give us warning of what will happen, as he did with adam and eve:God told them they could eat food from the trees of the garden. But from one tree God said not to eat, or else they would die. do you know what happened next
I disagree: of you understand the consequences of an action, and choose to do that that action anyway, then you're responsible... God knew all of the outcomes of the actions involved in creating heaven and the world, but chose to do so anyway.
It's the difference between a monkey picking up a gun and pulling the trigger and accidentally killing someone versus a man knowingly murdering someone... but with omniscience, and having created *everything*, and thusly, *knowingly* creating all consequences ever.
No, I just don't believe in the bible for a number of reasons including the one we were just discussing... Even *if* there *is* a God, then his word has become so totally corrupted, that you still might never find him in any organized religeon, or in any of their dogma/texts.
I believe that we are responsible for our actions, even if the bible (pherhaps inadvertently) says otherwise.
explain this warning: But know this, that in the last days+ critical times hard to deal with will be here. 2 For men will be lovers of themselves, lovers of money, boastful, haughty, blasphemers, disobedient to parents, unthankful, disloyal, 3 having no natural affection, not open to any agreement, slanderers, without self-control, fierce, without love of goodness, 4 betrayers, headstrong, puffed up with pride, lovers of pleasures rather than lovers of God, 5 having an appearance of godliness but proving false to its power;+ and from these turn away. 6 From among these arise men who slyly work their way into households and captivate weak women loaded down with sins, led by various desires, 7 always learning and yet never able to come to an accurate knowledge of truth.
My biblespeak is pretty rusty, but basically it appears to say that there will be non-believers, and that they could only be the scum-of-the-earth types... And what else would you expect from a book (and the religeon that it accompanoes) that offer no proof or realistic reasoning of any kind but big threats, and coarse (baseless) accusations of one's character and merit?
"oh, ya, if you don't believe all this than you must be scum... just because I said so, and I will offer no proof. In fact I'm going to leave metric tons of evidence to the contrary, but still unbelievers are unbelievers because 'they have no love for goodness' or whatever"...
I am none of those things your little book claims I am, and just saying so doesn't make it so.
If I made up a religeon, and wrote a book explaining that people wouldn't believe it for this reason and that, that would make everything else I wrote in it true?
So... whoever wrote the bible had some basic understand that there are different kinds of people... that have been here since the beginning of the human race? That's proof?
Hey, ya, "people are gonna be people today, tomorrow, and until the end of time", isn't really much of a prediction...
Funny, usually sheep are considered mindless whether they are shepherded or not...
The shepherd is a dusty old book for whole the only evidence of its validity is itself, and the charlatans and people who truly believe in it, but only because they had it drilled into them when they were children (read: before they had access to reasoning)
Do i? Do I really? 😄😄
Funny how our psycho-Christian nation-cult keeps blaming "the heathen" ("the infidel", if you will) for all its problems... Isn't it weird how religeon captains our little rock-flying-through-space, but when the shit hits the fan, only everybody else must go down with the ship...
Like 5% of the nation are atheist... and a lot more than that number are in prison (not to mention how the number increases by whole factors of you include crimes that go unsolved; only 1 in five murders get solved, for instance) so even if every single non-god-fearing person committed horrible crimes, there would still be *far* more Christians and whatnot committing crimes than "heathens"...
Neither have I... but that doesn't mean the entire demographic is perfectly innocent, does it?
About 10% of the American population is behind bars at any given moment, and only 5% of the population identify as atheists... so do the math... and then attempt to factor in unsolved crimes... There simply aren't enough atheists to answer for all crimes... and then factor in that 10% behind bars doesn't account for unsolved crimes...
You said "the infidels" we're ruining the earth by way of rape, and murder, and so on, when clearly that isn't the case... Can you at least concede that much?
And do you really want to start on the wildly varyied and inconsistant things the bible "teaches"us?
And to reiterate: I'm not saying there isn't a God, I'm saying the bible isn't the path to him... and that "he/she/it" is *necessarily* ANYTHING like we prefer to imagine him
@killer1000 (sorry Ikeep forgetting to include you, btw)
I'm not the least bit sure that *anybody* knows...
@killer1000 ...


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The Deal
- $25 for one ticket to The Big Toast ($50 value)
On September 27th, from 6 p.m. to 10 p.m., join the charitable organization Big Brothers Big Sisters of the Ocean State for an evening of 1920s-themed entertainment, loosely based on The Great Gatsby. Held at the historic Linden Place Museum, the event provides an opportunity to sample fine wines, beers, liquors, and gourmet cuisine while giving to a good cause.
The Big Toast
The Big Toast, a Great Gatsby-themed benefit for Big Brothers Big Sisters of The Ocean State, blends the decadence of the roaring 20s with the philanthropic spirit of the modern age. Partygoers are invited to dress in flapper dresses and fedoras (or business casual). They can also sample their fill of fine wines, craft beers, and quality liquors, celebrating just like the Prohibition-Era speakeasy dwellers did.
The evening's entertainment takes place at the Linden Place Museum. Throughout its storied history, the well-maintained mansion has entertained four presidents, generations of socialites, and famous performers such as Ethel Barrymore Colt. Appropriately enough, it even served as a set for the 1974 film adaptation of the The Great Gatsby.


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A broad range of cells are subjected to irregular time varying mechanical stimuli within the body, particularly in the respiratory and circulatory systems. Mechanical stretch is an important factor in determining cell function; however, the effects of variable stretch remain unexplored. In order to investigate the effects of variable stretch, we designed, built and tested a uniaxial stretching device that can stretch three-dimensional tissue constructs while varying the strain amplitude from cycle to cycle. The device is the first to apply variable stretching signals to cells in tissues or three dimensional tissue constructs. Following device validation, we applied 20% uniaxial strain to Gelfoam samples seeded with neonatal rat lung fibroblasts with different levels of variability (0%, 25%, 50% and 75%). RT-PCR was then performed to measure the effects of variable stretch on key molecules involved in cell-matrix interactions including: collagen 1α, lysyl oxidase, α-actin, β1 integrin, β3 integrin, syndecan-4, and vascular endothelial growth factor-A. Adding variability to the stretching signal upregulated, downregulated or had no effect on mRNA production depending on the molecule and the amount of variability. In particular, syndecan-4 showed a statistically significant peak at 25% variability, suggesting that an optimal variability of strain may exist for production of this molecule. We conclude that cycle-by-cycle variability in strain influences the expression of molecules related to cell-matrix interactions and hence may be used to selectively tune the composition of tissue constructs.
Many cell types are sensitive to their mechanical environment. Hence, essential cell functions are influenced by the physiological levels of mechanical forces cells experience within the body.1 Primary examples of mechanical stimuli on cells are found in the respiratory and circulatory systems, where pressures due to tidal breathing and cardiac output, respectively, impart stretches on adherent cells. Most studies related to how cells respond to mechanical forces, mechanotransduction, have examined cells in isolation and focused on static and simple sinusoidal stretching patterns.2-6 However, cells in the body are subject to irregular and varying mechanical stimuli. In the respiratory system in particular, tidal breathing varies considerably in both frequency and amplitude,7 resulting in cell stretches that simple sine waves of constant amplitude and frequency do not reproduce.
Recently, there has been interest in the effects of irregularly varying mechanical stimuli on cell function. In particular, it has been shown in type II alveolar epithelial cells in culture that adding variability to the stretching stimulus can result in an increase in surfactant secretion.8 The stretch pattern applied to the epithelial cells randomly varied from cycle to cycle in both frequency and amplitude, but had the same mean frequency and amplitude as a constant sinusoidal pattern. Different levels of variability, defined as the interval around the mean from which random amplitudes were chosen, showed distinct levels of surfactant secretion. However, a limitation of this study was that these experiments were performed in two dimensional cell culture rather than with a three dimensional tissue or construct. While various stretching devices have been designed,9,10 to our knowledge, devices that can accommodate tissues have not been able to provide variable stretch patterns such as those found in the body. In order to further explore the effects of variable stretch on the function of a broader range of cells it is necessary to develop the tools to apply this type of stretch to three dimensional tissues and tissue-engineered constructs.
The primary purpose of this study was to design, build and test a uniaxial stretching device capable of delivering cyclic variable stretch to tissues and constructs in a controlled environment. Furthermore, we aimed to develop a multi-well tissue stretcher in order to be able to simultaneously stretch several samples that would provide for rapid experimental testing of novel hypotheses related to mechanotransduction. To this end, we developed such a system and used it for preliminary testing of the effects of variable stretch on mRNA expression of several intracellular and extracellular matrix (ECM)-related molecules in a collagen-based construct (Gelfoam) seeded with neonatal rat lung fibroblasts.
Figure 1A shows the relationship between the input and output distances for cyclic stretches performed at 0.5 Hz. The linear fit has a slope of 0.977 and an R2 of 0.999 thus showing that the output distance was consistent and linearly related to the input distance over the entire range of the actuator stroke. Figure 1B shows the dependence of the output distance on frequency, ranging from 0.1 to 2 Hz. The output distance remained within 2% of the desired distance (5 mm) for all tested frequencies. The repeatability of the stretch is shown in Figure 1C, where the solid line represents the stretch waveform at the beginning of a three hour stretch while the stars indicate the waveform at the conclusion of the stretch. The desired cyclic stretch had a frequency of 0.1 Hz and amplitude of 5 mm. The two curves are nearly identical, showing that the motion of the actuator was reproducible over the length of the experiment.
Mechanotransduction involves the translation of forces from the extracellular space into the cell leading to cellular response. To determine how variable stretch might modulate cell function we evaluated the relative expression of important ECM components (type 1 collagen, and lysyl oxidase (LOX)), cell surface ECM receptors (integrins and syndecan 4), a critical cytoskeletal component (α-smooth muscle actin) and vascular endothelial growth factor-A (VEGF) involved in maintaining cell viability and stimulating tissue repair. The expression level of each mRNA was evaluated at 0, 25, 50, and 75% variability. The monotonous sinusoidal (0% variability) condition had a sample size of 9, while all other conditions had a sample size of 3. Figure 2 shows the relative mRNA expressions of collagen 1α and LOX for increasing levels of variability. Both collagen 1α and LOX mRNA levels were elevated with increased variability and this was statistically significant among the groups with p = 0.033 for collagen 1α and p = 0.034 for LOX.
The relative expression of mRNA for α-actin and VEGF are shown in Figure 3. Both molecules exhibited a decreasing trend in expression at 25% variability in strain. The dependence of α-actin on variability was statistically significant among the group (p = 0.039), whereas VEGF nearly reached statistical significance (p = 0.066).
The expression of cell surface ECM receptors syndecan-4, β1 and β3 integrins is shown in Figure 4. Although β1 and β3 integrins did not show a statistically significant difference among groups (p = 0.075 and 0.260 respectively), syndecan-4 displayed a strong difference among groups (p = < 0.001). Furthermore, the mRNA level at 25% variability was different from the 0%, 50% and 75% variability conditions and the 0% variability condition was also statistically different from the 50% and 75% variability groups.
Cells in the body receive mechanical stimuli caused by the stresses and strains of locomotion, breathing, and due to various other physiological activities such as the heart pumping blood. The deformations that cells are exposed to are always irregular. For example, both the tidal volume of breathing7 and the ejection volume by the heart vary from cycle to cycle.11 Consequently, the mechanical stimuli that cells are exposed to within the ECM of the lung and the blood vessels also vary from cycle to cycle. Thus, it is likely that cells are tuned to recognize and respond to these variable mechanical inputs. In order to determine how such variability in strain might affect the expression of key ECM and cell related molecules, we designed, built and tested a uniaxial stretching device that can mechanically stimulate up to six tissue pieces or constructs at a time, delivering cycle to cycle variability. Although similar uniaxial stretchers exist in the literature,9,10 this is the first study to apply cycle-by-cycle variability in strain and frequency. In this study, we developed a device that is robust and can deliver reliable strains for long durations in the controlled environment of a cell incubator. Additionally, our preliminary exploration with the device suggests that variable stretch patterns can influence the expression of mRNA for several key molecules known to play important roles in cell-ECM interactions.
Although several uniaxial stretchers have been introduced some of which are also commercially available, this is the first device to allow the user to apply variability of strain on a cycle-by-cycle basis. Our stretcher is designed as a high throughput system that can stretch up to six samples under the same mechanical conditions while allowing for different biochemical conditions in different wells. Our system is ideal for biochemical analysis of cells and ECM in mechanically stimulated tissues and constructs. Commercially available systems such as LigaGen by Tissue Growth Technologies or ElectroForce BioDynamic Test Instruments by Bose cannot accommodate as many samples simultaneously and therefore require multiple experiments to achieve the same sample number. Such repeated experiments can increase the inter-sample variability of the data potentially requiring a further increase in sample number. The stretcher developed by Kluge et al. features multiple wells but also uses multiple actuators to deliver the strain.10 A disadvantage of our current system is the lack of force transducers, which prevents us from acquiring stress and stiffness data. The purpose of this device, however, was to be able to measure the biochemical response of multiple samples to mechanical stimulation. Moreover, the addition of force transducers to each well is still possible if deemed necessary. Nevertheless, it is not expected that significant deposition of the major structural molecules such as the collagens would occur during our short-term stretching and hence the stiffness of the samples is not likely to increase by the end of the protocol used in this study.
Our system features the following important design considerations: (1) the stretcher size and material composition allow it to be placed inside the controllable environment of an incubator; (2) the system can be easily sterilized using ethanol or UV light; (3) having six wells increases the sample number over current systems and also allows for simultaneous mechanical stimulation under different biochemical treatment conditions; (4) the system is flexible and can also be set up such that any of the samples receive static or no stretch while the rest of the samples undergo cyclic stretch; (5) the actuator can stretch up to 2 cm allowing a large range of strains; (6) the mechanism for clamping the samples allows easy and reliable mounting of tissues and constructs; and (7) the well size is minimized in order to concentrate any proteins released by the cells as well as to reduce the amount of reagents used in certain conditions.
The molecules chosen for mRNA analysis are integral to controlling the mechanical environment of cells in the ECM as well as the cells' own mechanical properties. For example, cells can regulate the stiffness of their environment by depositing type I collagen, an important structural protein of the ECM.12,13 LOX catalyzes the crosslinking of collagen and therefore can also regulate the stiffness of the ECM.14 Syndecan-4, β1 integrin and β3 integrin are membrane-bound receptors that function as ECM receptors transducing signals from the ECM into the cell15,16 whereas α-actin is a protein that is required for contractile force generation and also contributes to the stiffness of the cell.17 Finally, VEGF is a signaling protein that cells produce to enhance local cell viability and to promote vasculogenesis and angiogenesis.18 Mechanical stretch delivered as a cyclic monotonous waveform has been found to influence many molecules.19 For example, the mRNA expression of α1 procollagen was shown to be upregulated by stretch on elastin and laminin coated membranes but not on fibronectin.3 Mechanical stresses were shown to dynamically regulate syndecan-4 expression and relocation on cell surface.20 Additionally, 4 h of uniaxial cyclic stretch was found to upregulate the expression of integrin β3 in human umbilical endothelial cells, which may enhance their ability to adhere to the vessel wall.21
Our data obtained using the device in this preliminary investigation, however, suggest that mRNA expression of most of studied molecules is also sensitive to the introduction of variability with some molecules being upregulated while others downregulated. In particular, in fibroblasts seeded in collagen-based gelfoam constructs, actin mRNA production decreased at 25% variability, but recovered at larger levels of variability whereas syndecan-4 showed peak expression at 25% variability. The mRNA expression of collagen and LOX increased above control levels for larger levels of variability. The mRNA of VEGF and β1 integrin nearly reached significance with variability that may be achieved with a larger sample size. The only molecule whose mRNA expression did not show signs of sensitivity to variability was β3 integrin. Thus, there appear to be multiple and sophisticated mechanisms in place for cells to sense and respond to variable stretch-induced mechanical stimulation.
The most interesting result was observed with syndecan-4 mRNA, which also showed the strongest statistically significant differences among the different levels of variability. Syndecan-4 mRNA displayed a distinct peak in production at 25% variability, which then decreased at increasing levels of variability. In their paper on surfactant secretion, Arold et al. also showed a peak in surfactant secretion at an optimal level of variability.8 We note that actin also exhibited a similar behavior in that there was a specific level of variability or noise at which its mRNA production was maximally reduced. Such variability- or noise-enhanced signaling is similar to the phenomenon known as stochastic resonance that occurs in nonlinear systems where the addition of noise to the input signal can result in the amplification of the output.22,23 Stochastic resonance has been implicated in various biological phenomena.8,24-27 We speculate that physiological levels of variability must be optimal in some sense for the functioning of the cell or its components within its native mechanical and biochemical environment. Since the biochemical environment includes the composition of the ECM whereas the mechanical environment is a function of the organization of the ECM, our results are likely specific to the cell type and construct composition used.
With regard to the possible mechanisms of how variability around a mean level of stretch can influence signaling, we note the following. Even though this preliminary investigation did not allow us to reveal the detailed signaling mechanism by which variability in stretch regulates mRNA production of the proteins tested here, it is certainly true that signal transduction pathways are invariably nonlinear due to feedbacks in the reaction networks and Michaelis-Menten kinetics.28 As cells adhere to the ECM via cell surface receptors such as integrins, the stretch of the ECM fibers generates force in the integrins which is transmitted through various focal adhesion proteins to the actin cytoskeleton.29 Because of the complex structure of the focal adhesion and the network organization of the actin, this mechanical transmission pathway is nonlinear. While it is not known exactly how and where these mechanical signals are transduced into chemical signals, upregulation or downregulation of mRNA requires a certain threshold stimulus mostly due to feedback from the output to some components of the pathway itself perhaps through the NFκB pathway.30 Such threshold phenomena are inherently nonlinear. Depending on the specific pathway nonlinearities for a given molecule, the occasional larger than average stretch amplitudes can overcome the thresholds associated with that pathway and if this occurs a sufficient number of times, the baseline signal transduction generated by the monotonous sinusoidal stretching will be altered. Thus, the specific responses that we see in the various signal transduction pathways should depend on the specific nonlinearities in these pathways, the mean level and the variability of stretch as well as the total time of stretching.
It is also possible that due to the viscoelastic nature of both the cell and the ECM, different strain rates could generate different tensile forces on the focal adhesions that in turn could affect the final mRNA expression through the nonlinearities of the pathway. In our case, the time period of a given sinusoidal was proportional to the amplitude and hence the strain rate was constant for different cycles and across all variabilities. The strain rate was kept constant in order to avoid possible effects of increasing strain rate on mRNA expression, which we did not study specifically.
Considering that a broad range of cell types experience irregular mechanical stimuli, it is important to investigate the effects of variability on various cell functions. Our results demonstrate that the addition of variability can cause cells to alter their mRNA production for key molecules when compared with regular cyclic stretch. Furthermore, the specific effects of variability appear to differ among the different molecules studied. Depending on how lasting these effects are, it may thus be possible to differentially control cell function simply by adding variability to the stretching stimulus. This finding can have implications for future studies in mechanotransduction as well as tissue engineering. If, for example, cells can be stimulated to produce more collagen and LOX at different variabilities it may be possible to control the stiffness of tissue engineered constructs while other signal transduction pathways are not influenced. Likewise, physiological levels of variability may influence many other cell functions that warrants exploring in future experiments related to mechanotransduction.
A uniaxial stretching device was designed and built to deliver mechanical stimuli to native tissue or construct samples (Fig. 5A). The device, which measures 20 × 24 × 14 cm, is compact and can be placed inside a cell incubator so as to provide the appropriate environmental conditions such as temperature, humidity and CO2. The device consists of six wells, each of which can accommodate one sample. The wells measure 5 × 2 × 1 cm, and can accommodate up to 9 ml of media depending on the size of the sample. The six samples can be stretched simultaneously providing identical stretch to each sample or several samples can be held at a fixed strain and serve as controls. The tissue samples are secured within the wells on both sides by stainless steel clamps (Fig. 5B). The clamps consist of two parts: the top part snap fits onto the rods while the bottom part is joined to the top part by a stainless steel screw, securing the tissue between the two parts. One side of the clamps remains fixed, while the other can travel on a linear motion guide. The travel of the clamps, and thus the stretch of the tissue sample, is controlled by a linear actuator (Size 14 Linear Actuator, Haydon Kerk Motion Solutions) powered by a stepper motor that has a minimum step size of 25.4 µm. The stroke of the actuator is 2.54 cm, which is the maximum stretch that can be applied to any sample.
The linear actuator is controlled by custom built Labview software that delivers step and direction pulses to the actuator via a Labview DAQ (Labview DAQ 6221, National Instruments). The amplitude and frequency of stretch are controlled by the input of the corresponding step and direction signals delivered via the DAQ. The device can deliver static as well as cyclic stretching of the tissue sample. Furthermore, by delivering appropriate stretching signals, the device can stretch samples with cycle by cycle variability.
The device was calibrated by ensuring that the linear actuator traveled the specified distance, and therefore applied the correct strain to the tissue sample. The distance between a stationary point on the device and the linear motion guide was imaged during stretch (DSC-T70, Sony) and the travel distance was measured via MATLAB software developed in the laboratory. The device was imaged under different amplitudes and frequencies to verify the ability of the actuator to deliver the correct travel distances. Likewise, the ability of the actuator to be consistent over time was measured by comparing the initial and final cycles of a three hour long stretch.
The protocol was approved by the Boston University IACUC. Neonatal rat pulmonary fibroblasts (NNRLF) were isolated from 2–3 d old Sprague-Dawley rats and were cultured in Dulbecco's modified Eagle's medium (DMEM) with 5% fetal bovine serum (FBS), 1% penicillin/streptomycin antibiotic cocktail, 1% sodium pyruvate and 1% nonessential amino acids. The cells were cultured in flasks for one week before being seeded on Gelfoam constructs.
Gelfoam constructs (Pharmacia and Upjohn) were cut into 4 cm × 1 cm × 0.3 cm pieces the day before seeding and were equilibrated in NNRLF medium overnight prior to seeding. The constructs were seeded by spot pipetting 250,000 cells over the entire 4 cm × 1 cm surface. Samples were then placed in an incubator for 2–3 h and then into centrifuge tubes containing NNRLF medium. The medium was changed 24 h after seeding and at 3 d intervals thereafter. The constructs were cultured for 8 d before stretching.
Gelfoam constructs were stretched on the 8th day following seeding without changing the medium. Samples were attached to the device using the special clamps and the stretching was performed on six samples simultaneously. Two unstretched constructs were maintained as controls for each day. The two types of stimuli delivered were monotonous cyclic and variable cyclic stretch. Variable stretch delivers a sequence of sinusoids in which each cycle has a different strain amplitude (ε) and frequency (f). Here we defined the variability of the stretch signal to be an interval described by the percentage of the mean strain; thus, a signal with a mean strain of 20% and an imposed variability of 25% would deliver peak strains in each cycle in the range of 15 to 25% with equal probability. The corresponding strain and frequency were fixed by the equation εf = C, such that a larger peak strain would have a smaller frequency resulting in a constant strain rate.All stretched conditions received an average strain amplitude of 20% at an average frequency of 0.2 Hz. In total, there were four conditions: (1) monotonous stretch, which corresponds to 0% variability, and consists of a single repeated sinusoidal stretch at 20% strain (2) 25% variability, (3) 50% variability and (4) 75% variability. All stretches were applied for three hours. Following stretching, the samples were removed from the wells and cut from the clamps. Only the portion of the sample that experienced stretch was collected for analysis.
All Gelfoam samples were collected for total RNA purification immediately following stretching. The samples were washed using PBS and then cut into smaller pieces with scissors. Two samples of the same condition were combined into one to obtain enough RNA for analysis. A previously described protocol was used to extract the total RNA from the cut pieces.31
To remove genomic DNA, the RNA samples were incubated with RNase-free DNase I (New England BioLabs, M0303S) in conjunction with the use of an RNase inhibitor (Life Technologies, N808–0119). The cDNA was prepared by annealing the RNA with random hexamer and oligo dT primers and allowing the first strand synthesis to be performed with MuLV reverse transcriptase (Life Technologies, N808–0234). No reverse transcriptase was used in the negative controls. An Applied Biosystems 7300 Real-Time PCR system was used to carry out real-time PCR analysis. ABI TaqMan gene expression assays for rat collagen 1α (Rn00801649-gl), elastin (Rn01499782-m1), lysyl oxidase (Rn00566984-m1), α-smooth muscle actin (Mn01546133-m1), Vegf (Rn01511605-m1), syndecan-4 (Rn00561900-m1), β1 integrin (Mn01253227-m1) and β3 integrin (Rn00596601-m1) were used as target probes. Eukaryotic 18 S rRNA (4308329) was used as an endogenous control. Standard cycling parameters of 50°C for 10 min, 95°C for 2 min, and 40 cycles of 95°C for 15 sec and 60°C for 1 min were completed. Data were analyzed with the ΔΔCT method with 18 S rRNA as the endogenous control.
Data are presented as mean ± standard deviation for each group. Data were analyzed using one-way Anova and differences between groups were considered statistically different for p < 0.05.
No potential conflicts of interest were disclosed.
This work was supported by NIH grants HL-098976 and HL-088572.
Previously published online: www.landesbioscience.com/journals/biomatter/article/24650
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


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Bloons TD 5 Level 113 Tips and Strategies
Bloons TD 5
By: Ninja Kiwi
Genre: Action
Video Tips
This video walkthrough demonstrates how to beat Level 113 without any power ups. Uploaded on Tim NrwHf official channel at April 13, 2015.
Still need help to finish Bloons TD 5 level 113?
I will update this post with more tips and tricks, so please bookmark this page and keep on checking in!
If you have any questions, feel free to ask for extra help in the comments section.
Hit like if this helped you!
Visit Bloons TD 5 walkthrough page for level videos, tutorials, cheats and more.
Level 113 Questions
Questions related to level 113 of Bloons TD 5 iPhone game.


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Thornton-le-Moor Vacation Packages
Many of North Yorkshire's highlights can be found within easy reach of Thornton-le-Moor, so it is a convenient place to base yourself. Two attractions that should be on every visitor's itinerary is the fascinating Mount Grace Priory and the iconic Shandy Hall. Also, be sure to check out Byland Abbey and Blacksheep Brewery.
Do make the effort to see some of the nearby museums and galleries, which help make the area such a great vacation choice. In particular, you should make sure you check out the Darlington Railway Centre and Museum in Darlington.
If the weather is good head outside and make the most of the nearby parks and reserves. There are some pleasant gardens and parks, so why don't you go out and enjoy the Studley Royal Park in Harrogate and the Hemsley Walled Garden in York.
To really get a feel for the area, visit the nearby local attractions such as Richmond Castle in Richmond, Theakston Brewery in Ripon and Easby Abbey. These are a magnet for travellers from all the corners of the globe. Should you feel the need for a little spiritual renewal, spend a little time at the area's most sacred sites, such as the St Cuthbert Church in Darlington. Learn more about the events of the past by visiting heritage sites, such as Middleham Castle in Leyburn, Helmsley Castle in York and the Ripley Castle and Gardens in Harrogate.
To browse through stores or enjoy a snack, visit the Richmond Market Place in Richmond.
If you're a sports fan, be sure to catch local heroes, the Middlesbrough FC, doing battle at Riverside Stadium, Middlesbrough. On match days follow the sea of red and white, to the stadium, then after the final whistle blows, join local soccer lovers at a nearby pub, bar or cafe and relive the games finest moments over a few cold beers.
To make sure you get the most out of this fascinating part of the world, think about booking your accommodation at one of the area's hotel or serviced apartment options. Check out the rooms and rates at the St George Hotel, Darlington, the Tulip Inn York Burn Hall, or the Mercure Darlington Kings Hotel.


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Sri Lanka Navy today rescued 28 persons from an asylum seeker boat in trouble, which had attempted to flee to Australia.
Sri Lanka Navy had sought the assistance of a merchant vessel to rescue the group in distress and they were later brought to the Galle Harbour on a Navy vessel.
The Australia-bound group of illegal migrants had reportedly set sail from Valaichenai on July 13th.


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Whenever we go to Thornton Beach Ivey begs to see the "caballos"
So of course we did.
This time she was actually brave enough to ride one. His name was Cody.
She was so happy all she could talk about was Cody.
Ivey: "¿Dónde está Cody?"
Me: "En el granero"
Ivey: "¿Por qué?"
Me: "porque es su casa."
Ivey: "¿Mommy, dónde está Cody?"
Me: "I already told you honey, en el granero"
Sunday is for "fútbol"
Linden doesn't seem to enjoy it as much as Ivey, at least not yet.
Ivey's favorite part seems to be getting stamps.
My favorite is moments like this.
Did you enjoy this post?
If so, check out other posts participating in Sundays In My City at unknownmami.com.


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DBS check approved
Renewal date: Aug 2019
I have been working in the care profession for over three years, both with Age UK and as a live in private carer.
I am genuinely interested in the wellbeing and welfare of those around me. Compassion is one of my natural characteristics and this is important when looking after people. I am always respectful and kind.
I enjoy reading, walking, working out, films and music.
Please contact me if you are looking for a carer. I am available in evenings and weekends.


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Hi I'm Damian Press and I've worked 15 years professionally in Music studios. That has resulted in clients aquiring Universal Record deals, EMI publishing deals and international radio play.
From writing the first melody to performing and recording each instrument through to mixing and mastering - I bring professional experience to ensure your songs pull at the heart, tingle the mind and get feet on the dance floor.
I operate from a number of studios in Berlin that can be found off my website (damianpress.com) Ginsberg Studios is my studio studio base and can be found in the heart of Berlin. I use only state of the art equipment from API and Neumann to ensure that what is produced, mixed and mastered is the best it can possibly be. I also use a wide selection of guitars, amps and analog synths.
If you're interested in taking your project to the next level please get in touch
Onwards and Upwards,
Damian Press
Send me an email through 'Contact' button above and I'll get back to you asap.
Gear highlights
- API A2D preamp and AD converters
- Neumann microphones
- Joe Meek
- TLA Ivory
- Fender Twin Reverb 65 reissue amp
- 2 acoustic
- 2 electric
- loads of FX pedals and plug ins. Works in ProTools
- Ableton and Logic Pro. Roland
- Yamaha Analog Synths
Genres I specialize in
Terms of Service
3 revisions per project. Turn around time is 3 - 7 days.


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Manotick, Ontario, is a suburb of Ottawa on the Rideau River, immediately south of the suburbs Barrhaven and Riverside South and is about 25 km (16 mi) from downtown Ottawa. It has been part of the City of Ottawa since amalgamation in 2001. It had a 2011 population of 4520.
In the 1830s, a small settlement formed in the area of the newly constructed Long Island locks on the Rideau Canal, but no development was done in the area of present day Manotick. In 1859, when a bulkhead was constructed across the west branch of the Rideau River in the location of present day Manotick, entrepreneur Moss Kent Dickinson and his partner Joseph Merrill Currier obtained the water rights and constructed a stone mill, on the shores of the Rideau River. Mills established by Dickinson and Currier helped spur the development of the settlement. One of these, Watson's Mill, survives today (open to the public).
It was Dickinson, who in 1864 named the new village "Manotick," after the Ojibwa word meaning "island in the river". Dickinson House, built in 1863, was the first major building in Manotick. It served as a general store, bank, post office, and telegraph office. The Dickinson, Spratt, and Watson families, who owned/operated the grist mill, now known as Watson's Mill, used the house as their residence from 1870 to 1972. The house is currently furnished to give visitors an interpretation of what the space was like when the Dickinson family was in residence.
The original St. James Anglican Church was built of wood in a Norman style in 1876, on land donated by Moss Kent Dickinson. When a larger church was built in 1985, the original style and appearance, including a Norman tower, the original stained glass windows, plaques and much of the other furnishings were maintained.
As commercial traffic on the Rideau became less important, the population in the village declined. The population in the village rebounded as Manotick came to be viewed by some as a commuter community for Ottawa. It joined the City of Ottawa in 2001.
Map of Ottawa and Carleton County from Wikipedia Commons
Research Tips
The primary source for basic documents (vital statistics, land records, wills) for people who lived in the Province of Ontario is the Archives of Ontario, 134 Ian Macdonald Blvd, Toronto, Ontario, Canada M7A 2C5.
Early Records
Civil registration did not begin in the province until 1869. Before then there may be church records of baptisms and burials. For the most part these are still held by the denomination who recorded them. Copies of marriage records made pre-1869 had to be sent by individual clergymen to the registrar of the county in which the marriage took place. These marriage records are available through Ontario Archives, on micorfilm through LDS libraries, and on paid and unpaid websites, but because they were copied at the registrars' offices, they cannot be considered a primary source.
Vital Records after 1869
Birth, marriage and death registrations are not open to the public until a specific number of years after the event occurred. Births to 1915 are now available [October 2014]; dates for marriages and deaths are later. Birth and death registration was not universally carried out in the early years after its adoption. Deaths were more apt to be reported than births for several years. The more rural the area, the less likely it would be that these happenings were reported to the authorities.
Land Records and Wills
Information on how to access land records and wills is best sought on the Archives of Ontario website. An ancestor's land holding might be found on Canadian County Atlas Digital Project if he was in occupancy circa 1878.
Association for the Preservation of Ontario Land Registry Office Documents (APOLROD). A list of Land Registry Offices for all Counties of Ontario.
The original censuses are in the hands of Library and Archives Canada, known to Canadians as "LAC". Copies of original microfilms are online at the LAC website for all censuses up to 1911. Each census database is preceded with an explanation of the geographical area covered, the amount of material retained (some census division material has been lost), the questions on the census form, and whether there is a name index. Census divisions were redrawn as the population increased and more land was inhabited. The 1921 census is only available through Ancestry.ca, but it is free-to-view.
Hard-to-Find Places
E-books, Books and Newspapers
Researching in Eastern Ontario
The website of the Ottawa Branch of the Ontario Genealogical Society offers a number of search engines for databases of material they maintain:
The Society covers the counties of Carleton (combined with the city of Ottawa), Lanark, Renfrew, Prescott and Russell. There is a note on the website that the URL will be changing soon (Jun 2012). It may be best to "google" the Ottawa Branch of OGS.


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MOO104lf Mooka Jasper Pendant
features an abstract pattern of purple, yellow, and creamy white jasper. Each stone is topped with a sterling silver bail which allows the natural beauty of the stone to shine through.
38mm x 35mm (not including silver bail).
Each pendant comes with a product card with the name of the stone.


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Ambra Gift Box Duo 100 : 100ml room spray + 100ml home diffuser by Dr. Vranjes
Discover a rich fragrance with oriental notes.
Amber and Iris Flower are joined by Cistus, Patchouli, Labdanum, Sandalwood and Vanilla to create this elegant, sophisticated fragrance.
- Capacity: 100ml (each bottle)
- Diffuser scent lasts for approximately 6 weeks
- Includes natural bamboo reeds
- Elegant Dr Vranjes labels & apothecary style bottles
- Suitable for all rooms
- Wide range of Dr Vranjes scents available
Ambra Cathedral Bottle 100ml Spray and the 100ml home fragrance diffuser with Sticks are brought together into a refined Gift Box creating a stunning gift for anyone who loves scent decor.


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limiting downloads from the internet
1 Reply
Nov 26, 2007 at 7:38 UTC
Lots of options. We need more details.
Are you in an Windows Domain enviroment?
You could use ISA server from Microsoft, but to be honest, i prefer running SQUID. You can do it on Windows, or Linux.
I'm in a dev enviroment so i didn't want any proxying, only URL recording, and that is dead easy in Squid. I had a working config on windows in around 30 minutes.
You can enforce the proxy on IE via group policy. (I would also consider blocking port 80 outbound on your firewall)
(if you allow firefox, there is a msi installer with group policy on http:/
This discussion has been inactive for over a year.
You may get a better answer to your question by starting a new discussion.


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ID3D11DeviceContext::RSGetViewports method
Gets the array of viewports bound to the rasterizer stage.
void RSGetViewports( [in, out] UINT *pNumViewports, [out, optional] D3D11_VIEWPORT *pViewports );
- pNumViewports [in, out]
Type: UINT*
A pointer to a variable that, on input, specifies the number of viewports (ranges from 0 to D3D11_VIEWPORT_AND_SCISSORRECT_OBJECT_COUNT_PER_PIPELINE) in the pViewports array; on output, the variable contains the actual number of viewports that are bound to the rasterizer stage. If pViewports is NULL, RSGetViewports fills the variable with the number of viewports currently bound.Note In some versions of the Windows SDK, a debug device will raise an exception if the input value in the variable to which pNumViewports points is greater than D3D11_VIEWPORT_AND_SCISSORRECT_OBJECT_COUNT_PER_PIPELINE even if pViewports is NULL. The regular runtime ignores the value in the variable to which pNumViewports points when pViewports is NULL. This behavior of a debug device might be corrected in a future release of the Windows SDK.
- pViewports [out, optional]
Type: D3D11_VIEWPORT*
An array of D3D11_VIEWPORT structures for the viewports that are bound to the rasterizer stage. If the number of viewports (in the variable to which pNumViewports points) is greater than the actual number of viewports currently bound, unused elements of the array contain 0. For info about how the viewport size depends on the device feature level, which has changed between Direct3D 11 and Direct3D 10, see D3D11_VIEWPORT.
Return value
Returns nothing.
Windows Phone 8: This API is supported.
See also


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Scotland is a country with an impressive heritage! It's culture, music, food and countryside all make this wondrous country great! Most visitors to Scotland will no doubt want to take in at least one of the picturesque castles that are dotted across its beautiful landscape.
Whenever I visit Scotland I always try to visit one local castle… even if it takes a little drive or train journey – so I decided to share my (not so) secret, favourite castles.
1.) Edinburgh Castle
In the heart of Edinburgh, this castle sits on-top of the plug of an extinct volcano!
2.) Dunnottar Castle
Head to Dunnottar Castle in Stonehaven to watch the perfect ocean sunset. Come rain or shine, this medieval castle always gives all visitors a perfect vista over the north-eastern coast!
3.) Balmoral Castle
Balmoral Castle is situated in Royal Deeside. It's one of the largest (in use) castles in East Scotland! A favourite of the Royal Family, this castle is a regular retreat for the Queen to escape the hustle and bustle of Buckingham Palace! 🙂
4.) Glamis Castle
Glamis Castle has been open to the public since Earl and Countess of Strathmore and Kinghorne (who live there) granted access to visitors. It's a great place to enjoy the architecture of medieval Scotland! Pair this beautiful castle with some Tea and Scones and you have yourself a truly British day out…
…Just beware of the ghostly ghouls, this castle is apparently haunted!
5.) Drummond Castle & Gardens
Drummond Castle and gardens provide one of the best examples of formal terraced gardens in the whole of the UK! It's expanse of land and space also gives this vast estate truly beautiful grounds to appreciate!
6.) Stirling Castle
One of the largest and historically important castles in the whole of Scotland!
7.) Craigievar Castle
Once home to the Clan Sempill and Forbes family, Craigievar Castle is now a beautiful example of a harled castle in Scotland.
8.) Abbots Tower
Technically not a fully fledged castle, Abbots Tower is what I like to call a faux-castle! 🙂 It's fairytale beauty and architectural charm makes it well worth a visit! Castle or tower… Abbots "Tower" is a great piece of Scottish history.
9.) Caerlaverock Castle
Caerlaverock Castle is a moated triangular castle in Dumfries. Truly, a favourite of mine!
10.) Cawdor Castle
Based in Naim, Cawdor is a castle that has grown throughout the centuries! It is best known for the connection to William Shakespeare's tragedy Macbeth!
11.) Culzean Castle
Little needs to be explained with this beautiful castle… just take my money and let me visit 😉
12.) Eilean Donan Castle
This castle seems to be on every Scottish postcard! The picturesque charm is reason enough to visit this magical castle! Truly breathtaking! 🙂
13.) Inverness Castle
Based in the centre of Inverness, this castle is great to explore one of the more "modern" Scottish castles… and by modern I mean 200-300 years old! 🙂
14.) Dunrobin Castle
Why not stay in Dunrobin Castle and have a perfect, luxury island retreat!
Read More On Creating Your Own Ultimate Adventure In The Highlands of Scotland!


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I just wanted to let you know that we purchased 4 dog tags a few years and one for our new puppy this week. Not only are all your designs super cool, the ones we ordered several years ago are in perfect condition along with the contact info on the back. I've never had a dog tag last more than a year. Your product is top notch!!! —Jenny Garner
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I could not be more satisfied with the Dog Tag Art tags that I recently purchased. The selection was creative and whimsical, the order arrived quickly and the tags are made of high quality materials with brilliant colors. Definitely far above the usual fare! The tags have garnered many compliments! Thanks for a wonderfully unique product! —Sue Hawk
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By JOHN J. O'CONNOR
Published: May 14, 1987
WHEN a network pre- empts its regular programming for cartoons, there is always the embarrassing prospect that nobody will notice the difference. But CBS is plunging ahead tomorrow evening anyway, with two half-hour animation specials based on popular comic strips: ''Blondie and Dagwood'' at 8, and ''Cathy'' at 8:30.
Produced and directed by Mike Joens for Marvel Comics and King Features Inc., in association with Toei Animation, ''Blondie and Dagwood'' brings us the dizzy Bumsteads, created by Chic Young in 1930 and still flourishing under the guidance of his son, Dean Young, and Stan Drake. In case you think that silliness doesn't pay, consider the figures: Today ''Blondie'' is carried in over 2,000 newspapers in 55 countries. Its estimated readership: 250 million. If the strip's appeal is broad, it can hardly be more than a millimeter deep, as Mr. Young continues to explore what he calls the ''four basic elements'' of living: eating, sleeping, raising a family and making money. ''Blondie'' tackles all of these and more, but with an exaggeration that is rarely taxing. Blondie, pert and efficient, and Dagwood, earnest and bumbling, are the Tom and Jerry of suburban living. Together with their rather patronizing children, Alexander and Cookie, not to mention Daisy the dog and Dagwood's always fuming boss, Mr. Dithers, they are subjected to all sorts of dreadful disasters but inevitably wind up wiser and miraculously whole.
The television scenario cooked up by the writers, Bob Smith and Barry O'Brien, is almost slavishly faithful to the comic strip, right down to the postman who is always knocked over by Dagwood, rushing out the door to work. The action, in short, remains dopey, the stuff of the kind of movie second-features that once starred Penny Singleton and Arthur Lake as the Bumsteads. But the ''Blondie'' strip has one outstanding asset: the line drawings, simple and uncluttered, yet wonderfully distinctive. The ''Blondie'' look was always more impressive than its text. The same is true of this TV adaptation. For the record, Loni Anderson supplies the voice for Blondie.
''Cathy,'' created and written by Cathy Guisewite, has far more pointed contacts with contemporary realities. Ms. Guisewite devised her comic-strip character in the mid-1970's - it now appears in 500 papers in 14 countries - as a vehicle for describing her own personal experiences, many of them, she concedes, in the category of ''most humiliating life moments.'' In any event, the character of Cathy, distinguished by two closely-set eyes and no nose, has become a clever running commentary on the joys and frustrations of being a single woman.
Cathy is a successful career woman who still has to cope with a mother constantly worried about her not being married. ''Single women have more cellulose,'' Mom insists. Cathy has a ''relationship'' with Irving, who is not beyond dating someone else when she insists on working at the office on Saturday nights. ''You failed me, Cosmo,'' Cathy cries. Cathy's friend Andrea is more determined. Come on, she says, ''we're going to find you a worthy date if we have to hit every sushi bar in town.'' Occasionally uncertain but always determined, Cathy pushes on, trying to be independent even while admitting that there is ''no place in the world more lonely than a single person's apartment without the phone-messages light blinking.''
Directed by Evert Brown for Lee Mendelson-Bill Melendez Productions, ''Cathy'' is the animated equivalent of clever, sophisticate sitcom. It fits snugly into network prime time.


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Monday, May 16, 2011
The JOBC Contest
What was his name?
The first person that e-mails me the correct answer at email@example.com will win a commemorative Greg Maddux 3000th strikeout scorecard, an autographed copy of the excellent baseball novel "The Pitch" (by Hank Owens), plus a t-shirt from the Just One Bad Century catalog.
UPDATE: Congratulations to Bill Whitburn, the first person to e-mail me the correct answer. He knew that Fred Merkle, the notorious Boner or Bonehead, was the first baseman on that 1918 World Series Cubs team. (Read all about Boner's story here.)
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Global Garage Flooring® & Design is currently seeking to expand its national network of Global Garage Dealers with individuals who are ready to break the mold of the traditional franchise model and succeed on their own terms. What We Do As one of the premier garage refinishing and coating companies in North America, Global Garage Flooring® and Design offers complete garage makeover solutions from custom industrial strength concrete floor coatings to top of the line cabinetry. A secondary component of our business entails a focus on commercial and industrial flooring applications.
Three Lines of Revenue Stream;
It's a Great Time to Be in the Garage Global Garage Flooring® and Design is a FUN business with a Low Investment in the rising Housing Industry! Scalable business model that can be built one trailer at a time – Home, office, shop or retail based. We use patented, high-quality products, offer protected territories and have a wide availability of markets nationwide.
Full Training and Support
& quot;Global Garage is a fun business to be involved in. We are always dealing with clients who are looking forward to improving the appearance of their garage, and they are thrilled with the results we can provide.& quot; - Paul Leonard, Franchisee in Denver, CO
What Qualifies You to be a Global Garage Franchisee?
If you're looking for a career that looks more like a one of our finished garage makeovers (interesting, fun, clean, low stress) Global Garage is worth further investigation.
SuperGreen Solutions is a leading a franchise in commercial energy efficient solutions, making us truly a 'one stop energy efficient solution shop'. Having been in the Energy Efficiency industry for over eighteen years the founders have established a solid reputation spanning three continents. We are different because we look at energy creation and energy saving from a holistic point of view, to provide our clients with total solutions.
As one of only a few companies having international training, experience and accreditation, the SuperGreen Solutions team is well educated to deliver the best advice and supply the latest products. Training has come from the A.B.S.A (Association of Building Sustainability Assessors), B.E.R.S. Pro (Building Energy Rating System) software training, H.I.A. Greensmart Accreditation and local LEED membership and training. This keeps us focused on achieving total energy efficient solutions to benefit all parties.
State of the art Showroom - Why not make our staff and showroom facilities an extension of your business? Builders are encouraged to send clients to our state of the art showroom, where we visually display and demonstrate the features, benefits and long term savings delivered through green products. This facility often helps clients better understand the products resulting in long term savings for all parties.
The most important decision in opening your retail business is site selection. We carefully research all aspects of every new SuperGreen site, such as traffic patterns and client potential. After all criteria are met and a location has been selected, we assist you in the negotiation of your lease and the store build-out.
Once you feel comfortable with the site selection of your new store and all lease terms are finalized, you are then prepared for ownership and the start-up process.
Product range - As long term suppliers of energy efficient products, we are acutely aware of the environment and performance requirements sought within this region. Just as the region and the needs of our client base are diverse, so too is our product range. What never alters is that our product range has been selected based on quality, reputation, proven performance and an underlying preference to products that are American made. Our products span several categories in the green and energy industries:
The SuperGreen training system is one of the most extensive training programs in the franchising industry and backed by over 18 years of experience in energy efficiency and green solutions.
Your comprehensive SuperGreen Solutions training program includes the following:
As a SuperGreen franchisee, you will have access to the ongoing support from a team of trained professional individuals. They are here to assist you in all areas including training, consulting, marketing, equipment, research, and technical support.
When you join the SuperGreen family, you will experience the satisfaction of owning your own business while enjoying the benefits that come from being part of a global brand businesses already know and trust.
As part of the United Franchise Group, our growing franchise family headquartered in West Palm Beach, FL SuperGreen Solutions has over 160 employees at corporate headquarters and the 14 regional offices throughout the United States, Canada, and Australia. Master Franchise Partners are growing in countries such as the United Kingdom, New Zealand, South Africa, Asia, Spain, France, Thailand, India, Portugal, and the Netherlands.
We also award very unique MASTER LICENSE opportunities for targeted countries/regions to qualified individuals and companies.
A master license grants the owner the exclusive development privileges for the brand and generates a very positive cash flow stream from the selling of franchises and collecting royalties.
Interested parties should have at least $50,000 to invest.
No, thanks.
Cartridge World operates in an $80 billion global industry where every household and enterprise needing to print is a potential customer. Cartridge World provides a consistent, high-quality product that is uniquely controlled to guarantee end-users, return time and time again. As a franchisee, this is your key to building a meaningful and rewarding business.
We are an established global brand and have been in existence for more than 20 years. This is so important when considering a franchise investment. But we have not stood still in that time; in fact, we have evolved into leaders within the print consumable industry, pioneering new innovations that can provide new revenue streams for our global franchise network.
Cartridge World's award-winning brand and global recognition, new revenue streams, the Global Procurement Center, innovations in the mobile printing sector and worldwide reach in 55 countries with more than 1,000 franchise locations sets us apart as an industry leader and makes it an exciting time to become part of our success and the Cartridge World global network.
The Owner Operator Program provides special access to an expanded portfolio of benefits including:
The Farmers Insurance Agency Owner Operator Program is designed to give well-capitalized professionals a turn-key system to quickly build a start-up Exclusive Agency. There are other specialized programs that give you the ability to purchase a pre-existing agency, instead of starting from scratch.
Farmers Insurance is not a Franchise Opportunity. There are No Franchise Start-up and No Royalty Fees but you still can take advantage of an established business model and training to grow your own insurance agency.
Our unique program is backed by a local District Manager and Territory Team that provide a multitude of resources in the form of Agency Business Consultant, Life & Financial Services specialist, Wealth Management Consultants, Commercial Wholesaler, Marketing manager, etc. In addition you will have access to one of the top corporate training programs from the University of Farmers
The qualified Owner Operator Program candidate will have:
We offer services perfectly suited for today's connected world. As wireless and mobile usage increases, devices become more and more important to all of us. Once a phone or device purchase is made, keeping the information on that device intact and staying connected to friends, family or colleagues for work, business or pleasure is critical.
Whether our customers are at home, on the job, in the office or visiting one of our stores, Tekkeez Tech Repair is ready to provide prompt and courteous service.
Tekkeez Tech Repair offers convenient, professional device repair services for customers who are looking for a trusted, local provider and in some cases, are just too busy to get to the store. Our stores and mobile service operators strive to deliver exceptional services where they are needed most.
Students are a growing target consumer group as tablets are launched in many school districts as learning tools. Businesses maintain an assortment of tech devices for employees that need ongoing maintenance. Tekkeez Tech Repair is well-positioned to serve all of these customers.
We added computer repair, gaming console services and enhanced our inventory of accessories to better meet the needs of our customers. As we grow, we continue to offer the most up-to-date services and identify new products.
We tell our customers that Tekkeez Tech Repair wants to put the 'EZ' back into repairing your tech devices. We have seen that accidents can happen to anyone at any time. You try to be careful, but somehow unexpectedly, you crack the screen on your new Apple® iPhone or crush your iPad in your backpack. Tekkeez is there to help you get your device back!
We are looking for individuals who are ready to establish a successful retail service destination in their local market. Although we are a tech service provider, technical skills are not a requirement to operate our stores.
Having a desire to operate a business that is closely integrated with today's technology infrastructure is certainly recommended. Your management and leadership skills will have an important influence on your business. Ultimately, it's a fit between you and Tekkeez Tech Repair that will make the difference and qualify you to join us.
If you have been looking for an opportunity to get into the phone repair market, we would like to get to know you, your talents and skills. We will provide you with the details you need about Tekkeez Tech Repair to help you make an informed business decision.
We recommend approximately $25,000 in liquid assets and a net worth of $75,000 for a single store. Your total investment may vary depending on factors unique to your situation.
Tekkeez is committed to helping you succeed and we look forward to being with you every step of the way. We provide business development support and ongoing assistance for your business needs.
We invite you to join Tekkeez Tech Repair as we grow our brand to be a trusted, local service provider that customers count on for all their device maintenance and repair needs. Tekkeez believes in the power of local, small business operators to make a difference in their communities and bring much needed services where they are needed most.
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Nanomaterial-assisted laser desorption ionization for mass spectrometry-based biomedical analysis
Nanomaterials have been widely used to assist laser desorption ionization of biomolecules for mass spectrometry analysis. Compared with classical matrix-assisted laser desorption ionization, strategies based on nanomaterial-assisted ionization generate a clean background, which is of great benefit for the qualitative and quantitative analysis of small biomolecules, such as therapeutic and diagnostic molecules. As label-free platforms, they have successfully been used for high-throughput enzyme activity/inhibition monitoring and also for tissue imaging to map in situ the distribution of peptides, metabolites and drugs. In addition to widely used porous silicon nanomaterials, gold nanoparticles can be easily chemically modified by thiol-containing compounds, opening novel interesting perspectives. Such functionalized nanoparticles have been used both as probes to extract target molecules and as matrices to assist laser desorption ionization for developing new enzyme immunoassays or for studying DNA hybridization. More recently, semiconductor nanomaterials or quantum dots acting as photosensitive centers to induce insource redox reactions for proteomics and to investigate biomolecule oxidation for metabolomics have been shown to offer new analytical strategies.
- doi:10.2217/NNM.10.127
- View record in Web of Science
Keywords: gold nanoparticle ; ionization ; laser desorption ; mass spectrometry ; mass spectrometry imaging ; photo-oxidation/reduction ; porous-silicon ; titania ; Atmospheric-Pressure Desorption/Ionization ; Multi-Phosphorylated Peptides ; Maldi-Tof-Ms ; Porous Silicon ; Small Molecules ; Gold Nanoparticles ; Quantitative-Analysis ; Carbon Nanotubes ; Aluminum Foil ; Target Plate
Record created on 2011-12-16, modified on 2017-05-12


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10 predictions for the 2014 US Open
Rory McIlroy won't win but he'll lead at some point. Phil Mickelson won't win, either. So who will win?
More Golf: Leaderboard | Rankings | Schedule | Equipment | FedEx Cup | US Open
Let's be honest for a minute. The US Open is usually a complete and utter train wreck. Back nine pileups, eights on holes, nines on holes, four-putts, five-putts, and a whole fleet of golfers leaving on the weekend pissed off at what the USGA did to them.
You know what? I kind of like it.
This tournament is unique in how tough it is and I kind of enjoy watching these golfers struggle in the same ways I struggle with golf (even if it takes a near-fantasyland golf course to make them do it).
With that, I have 10 predictions for this year's US Open.
1. Phil Mickelson will finish in the top 10: But he won't win. Lefty is too wily to not play well here but he likes to be cranking going into majors and he's just not this season.
He's playing okay but fooling around with his putting grip at the St. Jude Classic and all the other distractions will prove too much (this means he'll win by six).
2. We will get a Monday finish: Whether from rain or a playoff, I think this thing finishes up on Monday afternoon. Bonus golf, never a bad thing. Especially in majors.
3. Rory McIlroy will lead at some point after Thursday: This feels like the Ulsterman's tournament to lose. I know that sounds batty considering he hasn't won on the PGA Tour in the last two calendar years.
But he's one of the few golfers in the field who knows what it takes to hold this trophy and he's been immense of late. If he can grind, he will win.
4. There will be more rounds in the 80s than the 60s: Look no further than last year at Merion. There were 23 rounds in the 60s and 32 in the 80s. The amateur aspect of USGA events lends itself to that. In 2005 at Pinehurst there were 29 rounds in the 60s and 28 in the 80s so it's probably going to be close.
5. Someone will birdie No. 18 on the weekend: Not a bold prediction, you say?! Not a hot enough sports take, you think?! It didn't happen last year.
6. A score of 279 will win the tournament: In 1999 Payne Stewart won it with a 279 and Michael Campbell took it home with a 280 in 2005. 1 under or 2 under with the rough gone seems appropriate. I wouldn't be stunned if 3 under or 4 under won it, though.
7. Jordan Spieth will miss the cut: Yeah, I don't know, just a feeling here. I predicted Bubba Watson to miss the Masters cut in April and he won the dang thing. The learning curve at the US Open is the steepest and I'm not sure how far along Spieth is on it yet.
8. Cory Whitsett will be low amateur: Coming off his second straight national title at Alabama Whitsett blew away the field in his sectional qualifier, shooting 66-66. Roll amateurs!
9. Tiger Woods won't win: I promise you, guys, it won't happen. Tiger Woods will not get major No. 15 at Pinehurst this season. I guarantee it!
10. Charl Schwartzel will: Schwartzel has finished top 15 in two of his last three US Opens and has top 15 finishes in three of his last four PGA Tour events. He's a good putter, a good driver, and a good enough scrambler.
The only stat that worries me is his greens in regulation percentage but, well, I don't think many folks will be hitting greens in regulation this week.
Schwartzel gets his second major this week.
For more golf news, rumors and analysis, follow @EyeOnGolf and @KylePorterCBS on Twitter or Google+ and like us on Facebook.
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Thompson, U.S. retain Solheim Cup
Lexi Thompson got a clutch half point, and the U.S. was off to the races


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Artist's description:
A small portrait - painted as a study for larger works.
Concentrating on the essence of the portrait.
Painted in oil on a small box canvas, this comes ready to hang or can be popped into a frame if desired.
Comes with signed certificate of authenticity.
Materials used:
canvas, oil paint
Sweet Surprise (2016)
Oil painting by Jackie Whall
- Oil painting on Canvas
- One of a kind artwork
- Size: 4.92 x 7.09 x 0.59 in / 4.92 x 7.09 in (actual image size)
- Signed on the front
- Ready to hang
- Style: Expressive and gestural
- Subject: People and portraits
More by Jackie Whall View all
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Oil paintingby Jackie Whall
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Portrait study 20160401
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text: San Francisco Visiting San Francisco Is Like Visiting Heaven. This here bridge was made in 1937. 200,000 people walked this bridge higher than 1.7 miles to celebrate its grand opening. Here is one of many hotels,This one happens to be my absolute favorite.You can relax in a gorgeous hotel just like this one for a low price. Every thing you need in this room. The North Beach is where you can make a bunch of memories with your wonderful family. Enjoy your time with peace and relaxation. This Cable Car is the only moving National Monument! It Was built in 1873. If you want more information,stop by the museum, bonus its free. To go to San Francisco,you will most likely go by an airplane. The ride takes about 26 hrs or less to get to your destination. Now this is for anyone curios about whats right under the boat your probably standing on right now.Scuba diving is something You should try. Imagine eating delicious food at a wonderful restaurant with your gorgeous family having the time of your life. Just a quick ,nice view of this wonderful place also known as San Francisco,California. The Golden Gate Park,San Francisco's largest park,You can rent a boat and drift around the lake.In 1984 this was named Huntington Falls.


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Popular Now
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01803 865913
+44 1803 865913
By: Alain Grée(Author)
22 pages, colour illustrations
Guild of Master Craftsmen Publications
Alain Gree's beautiful illustrations from the 1960s and 70s are known throughout the world. With their naivety of form and bold use of colour, their charm is undeniable. My First book of Nature features Alain Gree's stunning vintage illustrations on every page. Aimed at children aged 0 to 2 years, My First book of Nature is a robust, wipeable board book with rounded corners. Its vibrant pictures and large, bold text will make learning about the natural world around them fun and absorbing for young children and toddlers.
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Alain Gree is a French author and illustrator of children's books. He has had over 300 books published, which have been translated into 20 different languages. He is currently a graphic designer and editor for various advertising publications. Alain's main hobby is sailing. He has owned several boats since the 1970s and has crossed the Atlantic Ocean twice. He finds his sailing trips provide the perfect time out to work on new children's stories and illustrations.
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Is it more important for your date to...
- get to know you?Vote A
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- just get you into bed?Vote C
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i don't need to date since prostitutes exist
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text: Pensioner Receives Payout After Suffering Severe Skin Burns From Leather Sofa Chemical Burn Injuries From Sofa 02.09.2009 A West Midlands pensioner has received a four figure compensation settlement after he suffered severe chemical burns and skin sores from a leather sofa which contained a highly toxic pesticide.Several thousand angry consumers are currently embroiled in legal action over health problems linked to leather sofas imported from China, which were later discovered to contain the toxic fungicide, di-methyl fumarate (DMF.) Leading law firm, Irwin Mitchell solicitors, have now obtained the out of court settlement - believed to be one of the first successful payouts to a UK 'toxic sofa' victim – on behalf of 68 year old Maurice Heminsley from Willenhall.Widower, Mr Heminsley, purchased the new £1,100 leather sofa from independent retailer, Furniture Warehouse, in Netherton, Dudley, in November 2007.However, within days, he began to suffer from a rash which spread across his neck, back and legs. Over the course of the next three months the rash developed into weeping, open sores which refused to heal. Mr Heminsley finally had to be hospitalised on 29 February 2008, where he was treated for acute contact dermatitis.His sister, Joyce Barham, explained: "He was in a terrible state. He had been suffering for more than a week before he finally confided in us that he had a painful rash. "Because the rash was on the back of his shoulders and legs he was unable to see the full extent of his injuries, but when we saw the horrific open sores we were in shock. He had been in so much pain but, as is typical of him, he hadn't complained as he didn't want to make a fuss."Mr Heminsley has now received an undisclosed four figure payout for his injuries, together with a full refund of £1,100 in respect of the defective sofa, from Dudley based Furniture Warehouse, who did not contest liability.Thousands of Chinese manufactured leather sofas were sold throughout 2007 and early 2008 by a number of UK retailers, including Argos, Walmseys, Land of Leather and more than a dozen independent furniture retailers. The sofas had been packed with sachets of the anti-mould chemical, DMF, to stop the leather from going mouldy during storage in humid conditions.Miss Toni Long, a solicitor with Irwin Mitchell, who represented Mr Heminsley, said:"Consumers quite rightly expect certain standards to be met throughout every stage of the manufacture and packaging process. "As of 1st May 2009 the European Commission has banned products containing the biocide DMF from being placed or made available on the market."The responsibility for the recall of all known products, which have been sold that contained DMF, has been placed on local Trading Standards. It is hoped that the larger retailers involved in legal action over 'toxic sofas', will be able to move swiftly towards settlement of the large number of similar claims against them."Mr Heminsley commented: "The settlement means I can now put this really painful episode in the past and move on with my life. However, I'm annoyed that more wasn't done to protect consumers. I think more should have been done to withdraw them from sale as soon as the manufacturers knew there was a problem." Related articles 17.08.2017Settlement For Family Of Elderly Man Who Died After Being Hit By Car As He Crossed The Road 16.08.2017NHS Figures Show Rise In Number Of Birth Injury Cases 11.08.2017Devastated Widow Takes Important Step In Legal Battle Following Husband's Sudden Death 11.08.2017Daughter Of Electric Furnace Maker Appeals For Answers After His Death From Asbestos Cancer 10.08.2017Operation Shelter: Specialist Lawyers Hope Convictions Will Encourage Abuse Survivors To Come Forward