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While the week before the Final Four drags on like a Streisand convention (think about it a second), please enjoy this commercial about getting your holes filled.
Monthly Archives: March 2012
Expectations and the Joyless Final Four
The date was March 27th, 2011.
My brother and I had just finished watching our 4th seeded Kentucky Wildcats knock off the 2nd seeded North Carolina Tarheels in thrilling fashion. As the realization that our beloved Wildcats were finally going back to the Final Four after 13 long years sank in, we screamed and jumped around like tweens at a Justin Bieber concert. Victory had never tasted much sweeter.
Flash forward to all but a year later and I'm sitting alone in my garage watching Kentucky dominate an over-matched Baylor team to reach their second straight Final Four. I had been confined to my "man cave" for poor behavior, as the weight of expectations had caused my scream-reflex to have a hairier trigger than most seasons.
As the minutes slowly ticked off the clock, there was no celebration in my solitary screen-room. There was only relief. This was expected, better yet, this was required.
With a roster stacked with at least 6 NBA players, Kentucky began this season as the 2nd rated team in the nation, trailing only the aforementioned Tarheels who combined similar NBA talent with "experience". As the year progressed, we saw Heels and Orangemen fall to the wayside, and the Wildcats emerged as the "clear favorite" to win the title.
In a season that saw Kentucky beat the Tarheels, the Jayhawks, and the Cardinals OOC, they went 16-0 in the SEC. Going undefeated in a major conference hadn't happened for anyone since the 2003. It became increasingly clear that this group was truly a notch above everyone else.
This year's Kentucky team is such an over-whelming favorite to win it all that anything less than a shiny new National Title banner hanging in Rupp Arena will be deemed a failure. The expectations are so great, that we have writers like ESPN's Myron Medcalf openly suggesting that it's title or bust for the Cats.
Anything short of a national title for Kentucky will equal failure.
Let that sink in for a minute… In a sport where 68 teams are given equal opportunity to win the title, the Kentucky Wildcats are the only squad that can't lose at any point and have their season deemed a success. It's not just that they have the best shot to win the title. It's that they have to win the title.
For a fanbase that's only 3 seasons removed from the NIT, this sort of talk is sweet honey with a side of vinegar. This is what we wanted. We wanted to be on top. We wanted these expectations. In these waning hours of the greatest ball of all, though, doubt and paranoia can ruin the party.
We start projecting amazing powers on apathetic players like Perry Jones III, who probably cares as much about winning a tournament game as he does his next MWIII session on the XBox. We start imagining the taunts we will receive from opposing fanbases if we lose. "Biggest choke of all time", they'll say and we'll be forced to agree with them.
So, like the hottest girl in school, there really are no excuses for this team not to be the homecoming queen. It's all or it's nothing. It's the elation of a title 14 years in the making or it's questioning the one-and-done philosophy and whether our coach is capable of winning the big one.
The Final Four isn't enough, not this season. In short, in a year where Kentucky fans may experience their 8th National Title, there will be no joy riding along the way.
Sweet Emotions: Part II
Well, we can all breath a sigh of relief. At least two of those unbearable B1G teams can't hurt our eyes anymore.
Thankfully, yesterday saw Syracuse pull out a close one over Wisconsin and those filthy Cards mercy-killed Michigan State. Now we're left with an Ohio State team that does at least try to score and… Indiana. I feel better, don't you?
Some sweet hot mama with a face like a gent
Said my get up and go musta got up and went
Well I got good news, she's a real good liar
Cause the backstage boogie'll set your pants on fire
Mr. Tyler is talking to you, UNC and UK fans. I think. Let's move on to today's games:
10 Xavier vs. 3 Baylor
This would seem like a match-up nightmare on paper for the X-Men. Baylor has a plethora of athletic lottery picks and dead-eye Brady Heslip, who can't seem to miss when it matters. Thankfully for Xavier, games aren't played on paper. While Baylor has top 3 talent, they seem to have a bottom 3 motor at times. When the Bears have lost, it's been to tougher teams that have weathered the storm and delivered the kill shot. Xavier is a team that has been hammered by distractions and disappointments, and has seemed to come out stronger for it. Look for this game to be a lot closer than you might think.
13 Ohio vs. 1 UNC
With Wrist-Gate still in full force for the Heels, they must still feel kind of fortunate to draw an over-matched Ohio squad in the round of 16. Even without KM, UNC has an enormous talent advantage at nearly every position. Don't get me wrong, Ohio is a good team, who has had a great run. There's just no conceivable reason they should beat North Carolina. You could have said that about VCU and Kansas last year too, though…
4 Indiana vs. 1 Kentucky
As you all know, Indiana delivered the Wildcats one of their two losses on the season in dramatic, buzzer-beater fashion in Bloomington. The shot has been played over and over (and over and over) on ESPN all season long. While Indiana fans might cling to that game as proof that they will arise victorious once again, reality suggests this might be a bloodbath. Anthony Davis, who played his fewest minutes of the season against IU, has grown into the (likely) player of the year. Marquis Teague, who started the season as a turn-over waiting to happen, has been molded into the poised floor leader that Calipari's offense thrives on. Outside of the SEC tournament, Kentucky has looked nigh invincible. If teams focus on clogging the middle, then they shoot over them and beat them by double-digits. If opponents play them straight up, the Wildcats dish and dunk to double-digit wins. Add to that the revenge factor that Kentucky players have openly discussed, and you have to like their chances on a neutral floor.
11 NC State vs. 2 Kansas
The Wolfpack is back, or so it would seem. Mark Gottfried, who used to play a coach on TV, has ignited NC State from the last team in to a Sweet 16 success story. Just as admirable, Bill Self has taken a squad with little expectations going into the season and transformed them into a legit Final Four threat. From the outside, this game appears to be a strength on strength match-up of C.J. Leslie and Richard Howell versus Thomas Robinson and Jeff Withey. If that equates to anything close to a stale-mate, look for the guards to be the difference, as Tyshawn Taylor and Elijah Johnson use their new-found assertiveness to put away the Pack.
While not quite as sweet as yesterday's match-ups, there's still plenty to watch for with the ultimate national champion probably emerging from this group.
Sweet Emotions
Well, ladies and gents, things are about to get real. With the fun and excitement of the first weekend behind us, we are now left with serious games with serious implications and emotions in the Sweet 16. As Steven Tyler put it:
I pulled into town in a police car
Your daddy said I took you just a little too far
You're telling me things but your girlfriend lied
You can't catch me 'cause the rabbit done died
Yes it did
I'll just let that sink in for a minute. While we wait, here are my thoughts on today's Sweet 16 matchups:
4 Wisconsin vs. 1 Syracuse
I'm not going to lie. Any game featuring Wisconsin has the potential to make you want to stab your eyes out. That said, their combination of quality guard play and tough defense should make this game very competitive. The Syracuse zone forces teams to hit outside shots to win, something Wisconsin has shown it can do on occasion. There is potential for an upset, but here's hoping Syracuse uses their superior size and athleticism to spare us another round of "Bo Ball".
4 Louisville vs. 1 Michigan State
Based on the season thus far, this seems to be a match-up of similar teams on similar paths. Both teams play suffocating defense at times, both teams struggle to score, and both teams overcame mid-to-early season set-backs to win their conference tournament. While Michigan State is the higher seed, all but one of the personnel match-ups seem to favor a finally healthy Louisville roster. The problem is that one match-up happens to be Draymond Green, who can and has put his team on his back. If Louisville can somehow convert a high percentage of transition baskets, look for the Cardinals to advance.
6 Cincinnati vs. 2 Ohio State
While the Cardinals and Spartans might feel like they're looking in the mirror at one another, the Bearcats and Buckeyes couldn't be more different. Cincinnati seemed to switch gears from mediocre also-ran to true Final Four contender heading up to the tournament, while pre-season Final Four favorite Ohio State has gone the other direction. The Buckeyes will have the clear talent advantage and they should be able to force their tempo on a Bearcat attack that sometimes resembles a team from the Rec League Final Four. Still, I can't help but wonder if the Buckeyes will be able to return to form this late in the season.
7 Florida vs. 3 Marquette
On paper, this pairing would seem to favor the Golden Eagles. According to KenPom, Marquette has a balanced, efficient attack with the nation's #28 offense and #16 defense. The Gators trend toward the scoring side with the #3 offense and #73 defense. Marquette seems to be the tougher, more consistent team and with dynamite scoring from Darius Johnson-Odom and Big East POY Jae Crowder we could see them pull away. However, you can never under-estimate guard play in the NCAA tournament and Florida's can be unmatched at times. If the Gators are hitting outside shots, this could go down to the wire.
As we all pretend to be interested in what they're paying us to do, lets keep our fingers crossed that 4 potentially great match-ups all materialize tonight. See you tomorrow.
A "Big Hit" for the Future of Baseball?
March Madness. We love it. We live it. We breathe it. We drive our families and friends crazy with talk of brackets and upsets. For three weeks in March, it's the ONLY thing that matters, until it's over. At that point, the annual, "Oh no, what now?" feeling kicks in.
What's next is baseball. Spring training is already in full swing. Opening day of the regular baseball season is just two weeks away and it's time to start planning your fantasy league and dreaming of that breakout offensive season that no one else picked.
This year, there might be a LOT of increased offensive production if what I'm hearing about a new baseball bat is true. Baden Sports–you may be more familiar with their basketballs–has recently introduced a new baseball bat called the Axe. This is the first major change to the shape of a bat in over a century.
I spoke with the company and one of the first things they told me was that Ted Williams says in his book, "The Science of Hitting," that swinging a baseball bat is like swinging an axe. Apparently, an axe handle guides your hand into a proper position that fits flush at the bottom and increases leverage through the swing–something that a traditional baseball bat doesn't do.
Baden says: "The Axe bat promotes an ergonomically correct grip, a better fit, a less restricted swing and greater bat speed through the hitting zone."
Who's using it and what are the results?
Since this is such a new bat, big league players are just being introduced to it. It's been approved for use in MLB games in 2012, so the company is currently working with players at spring training. They can't "name names," but they will say that players from every club are taking at least practice swings and becoming familiar with the bat.
Jimmy Rollins of the Phillies hit a monster home run–his first of the season—on March 12 against the Pirates with the Axe bat. He'd been practicing with it, and his first time to the plate with the Axe someone from the dugout yelled, "Let loose with that bat, Jimmy!" He did, and hit it DEEP over the left field wall.
That was the first "official" home run, but I've done some digging and found a reliable report that among others, Oakland As first baseman Brandon Allen enjoyed his first outing with the Axe. On opening day of spring training, Allen hit a grand slam, a two-run double and drove in the go-ahead run in the 9th … all with the Axe. 7 RBIs. Not bad.
So maybe there's something to this new Axe baseball bat. Time will tell, but since my basketball team didn't even make March Madness this year, my tears are close to drying and I'm getting a jump start on putting a miserable basketball season behind me.
Baseball will fill my sports cravings over the next 6 months, and I'm paying close attention to what's happening with the Axe bat.
The Greatest Day Ever: Part II
Closing the books on the glorious masterpiece that was the first day of the NCAA tournament is done with the sweetest of sorrows, but fear not. Just like Groundhog Day, we get to hit the clock and do it again.
Here's what's peaked my interest for Day 2:
7 Florida vs. 10 UVA
This has to be one of the hardest games to pick that I can remember. Both teams have looked like top 10-15 material on occasion this season, but neither has found the consistency for that to materialize. Florida is #5 in KenPom's offensive efficiency and #121 on defense, while UVA is #104 on offense and #3 on defense. It should be interesting to see how this "strength-on-strength" match-up plays out.
Is The Wolfpack Back?
NC State gave UNC all it wanted in the ACC tournament and managed to scrape their way into the field.While the Wolfpack is obviously playing their best basketball of the year, San Diego St. seems to have put theirs well behind them. If C.J. Leslie and the Pack get going, they should have a good chance of not only beating the Aztecs, but possibly making a run at the Sweet 16.
Will The Mid-Major Bug Bite KU Again?
Kansas is a very good basketball team led by a POY candidate in Thomas Robinson. Kansas has also had lots of very good basketball teams that have lost to mid-major teams in shocking fashion. Detroit is no Kansas, but they have size, athleticism, and 5 guys averaging double-digits in scoring. I'm not saying it's going to happen, I'm just saying…
Here's to a great day of hoops. Hopefully we'll see a little more shock than chalk.
The Greatest Day Ever
Today marks the real beginning of the NCAA Tournament and one of my favorite days all year. The upsets, the overtimes, the buzzer-beaters, the Cinderellas… It all starts today.
Here what I'll be watching:
6 Murray St. vs. 11 Colorado St.
Are the Racers for real or have they been the benefactors of a dreadful schedule? Has Colorado State been "tested" against a tough MWC schedule or are they as mediocre as their record would indicate? We'll get the answers today and hopefully see Isaiah Cannon put on a show.
Early Exit Artists
Will the Louisville Cardinals and Vanderbilt Commodores continue their trend of high seeds and early exits? Logic tells you that with Louisville being the Big East tournament champs and Vanderbilt taking the SEC tournament title over #1 Kentucky this should be a no-brainer. My gut still tells me to trust neither win as a given against tough first round opponents.
Is Kentucky Still Kentucky?
After steam-rolling through the regular season, the Wildcats looked anything but dominant in the SEC tournament. Was that a result of a lack of motivation or a sign of regression? We might not get a full answer against an over-matched WKU squad, but it will be interesting to see if the Cats start strong.
There's just no equivalent to the excitement of knowing you're going to see so many games that mean so much for each team's players, coaches, and fans. It's the NFL playoffs turned up to 11. It's the NBA playoffs, if the players cared. It's March Madness and it knows no peer.


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"Excellent care overall"
About: The Heart Hospital The Heart Hospital London W1G 8PH
Posted by Anonymous
I found the nursing staff were truly amazing. I therefore found it upsetting to witness junior doctors treating nurses badly, I witness doctors shouting and being other wise rude to nursing staff on several occasions.....I also wanted to make a suggestion.... I suffer from generalized anxiety disorder....and I found medical staff had little knowledge of how to handle this...whilst I don't expect everyone to be expert (it is a heart hospital after all), maybe the hospital could run brief short training seminars for staff just to improve their perception and care of patients with mental health conditions.
Response from The Heart Hospital 3 years ago
Thank you for taking the time to feed back to us. We're so pleased you were happy with the care and attention you received from the Cardiothoracic nursing staff and will feed this back, however we are very sorry to hear about your recent experiences relating to medical staff. We would be grateful if you could contact our Patient Advice and Liaison Service (PALS) via email@example.com or by calling 0845 155 5000 ext 73042 so that we can investigate this matter further.
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subset: commoncrawl


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Question: What are the steps involved in the collective bargaining process
What are the steps involved in the collective bargaining process?
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View Solution:
Answer to relevant QuestionsDistinguish among mandatory, permissive, and prohibited bargaining issues. Distinguish between demotions, transfers, and promotions. Describe the following approaches to disciplinary action. • Hot stove rule: • Progressive disciplinary action: • Disciplinary action without punishment: What is the difference between NAFTA and CAFTA? What difficulties do virtual teams have in the global environment?
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3725 Grandview Manor Drive Cumming, GA 30028
- Listing Status Active
- Neighborhood Grandview Manor
- County Forsyth
- Year Built 2016
- Home Size 3240 sq.ft. (Source: not available)
- Sale Type Normal sale
Chatsworth B - 5 bedroom 3 full bath, bedroom and full bath on main. Beautiful open floor plan with all the bells and whistles!! Hardwoods throughout the main level and stairs. Wrought Iron railing. Gourmet Kitchen with granite countertops stainless steel appliances include double oven and separate cooktop. Granite in master bath. Laundry room upstairs with utility sink. Come see our model home which is the same plan!! This home will be ready to close in May/June 2016!
- Listing Status Active
- Neighborhood Grandview Manor
- County Forsyth
- Year Built 2016
- Home Size 3240 sq.ft. (Source: not available)
- Sale Type Normal sale
- Elementary Matt / Forsyth / Forsyth County, GA
- Middle
- High West Forsyth / Forsyth / Forsyth County, GA
Listing provided courtesy of TAYLOR MORRISON REALTY OF GA. Listing data displayed on this page comes from the Broker Reciprocity program of Georgia MLS. This information is considerd reliable but is not guaranteed.
Look Promising?
Want to schedule a showing? Have any questions? We're experts and ready to help!
Call us anytime at 404-965-4080
Listings identified with the FMLS IDX logo come from FMLS, are held by brokerage firms other than the owner of this website and the listing brokerage is identified in any listing details. Information is deemed reliable but is not guaranteed. ©2014 First Multiple Listing Service, Inc.
© 2014 North East Georgia MLS. the information provided is for the consumer's personal, noncommercial use and may not be used for any purpose other than to identify prospective properties that the consumer may be interested in purchasing. Some or all of the listings displayed may not belong to the firm whose web site is being visited.


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"Worsh hospital ever"
About: Medway Maritime Hospital Medway Maritime Hospital Gillingham ME7 5NY
Posted by Anonymous
The worst hospital I have ever been. Very dirty, the staff very rude and not caring about patients. I have been to the hospital with tonsilitis and given wrong antibiotic which did not work. I went back again and given another antibiotic even though I told them that I generally have a specific one because I had tonsilitis many times in the past but they refused to prescribe it. I tried the new antibiotic and worked but it did not clear the microbes well which means that few weeks ago I got it again. Fortunately I went to a locum which was brilliant and he recommended the antibiotic I usually had in the past for tonsilitis as he said it did not clear well with the other antibiotics. I feel bad that this staff in medway hospital treat people like this. They are completely unprofessional and have no idea that being a healthcarer is something more than prescribing and giving drugs without listening and understanding patients' needs. Shame on you!
Response from Medway Maritime Hospital 3 years ago
We are sorry to hear of your unsatisfactory experience at the hospital and if you would like to discuss this further please contact John Fletcher, Senior Matron, for the emergency department on 01634 830000 x3847 or Amanda Morrice, Clinical Director, on 01634 830000 x3035, who will be more than happy to look into your case further.
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MADness 2013
Don't Forget!
Things you should know before Departure
- We will leave from the University (Cafeteria). The MEETING POINT will be at 7:00 am, and the bus will leave at 07:15 am. Please, be PUNCTUAL. We won't wait for anyone, so be on time :)
- Bring your Passport or ID!
- Bring your ESN Card. It's essencial for taking part in all the activities during the trip
- Food to be Donated.
- Bring old clothes for the Glow Paint Party. We can't guarantee that the paint will be removable.
- Bring your own towels! The hostel won't provide you with one.
- We will create a Whatsapp Group in order to contact with you during the hole trip, so don't forget to check it frequently!
- Remember to bring you insurance card or medical insurance.
- After the check-in, you will have some free time to explore the city. Our first Tour is at 17:00h, so the MEETING POINT will be at 16:15h at the Hostel.
- The second Tour will start right after the first one.
- The bus that will take us to the Glow Paint Part will leave at 23:30h. The MEETING POINT will be at 22:30h at the Hostel
- From the party, we will leave at 5:30h, so be at the entrance of the club
- TIP: Take some clothes with you for changing after the Paint Party. It might be cold while going back to the hostel
- Our day will start at 10:00h, with the visit to Museo del Prado. Our MEETING POINT will be at 09:30h at the Hostel.
- After that we will go to the Gastronomical Event. DON'T FORGET to bring your donation!!
- At 17:00h the Tour around Madrid de los Borbones starts. MEETING POINT at 16.40h at the Puerta del Sol next to the horse statue in the middle of the park.
- The bus for going to the party will leave at 23.30h. MEETING POINT will be at 22.30h at the Hostel. From the party, you will be able to go back to the hostel at any time you want. There will be buses placed at the entrance of the club, that will drop you at Plaza España (really close from our Hostel)
- Check out time is at 11.00h. Make sure you have everything ready, as we will leave all our luggage at the bus before the last tour start, and won't go back to the hostel.
- The last tour begins at 12.00h. So, MEETING POINT will be at 11:30 at the Hostel.
- After the tour, we will enjoy the picnic at Parque del Retiro, and then, we will go back to Gandia
General Information
- Breakfast time: From 8:00 to 10:00
- Hostel Address: Calle Mesonero Romanos, 7, 28013 Madrid. (A Point on the Map)
- Hostel Telephone: 915 31 33 89
- Taxis in Madrid: 911 61 05 06 - 914 05 12 13
- Schedule is subject to change.


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I just don't want to move in with him. We've been together several years. We lived together before, but thanks to a new job and about a million other things, I moved out and got my own place. It was an amicable split, and we did not break up. Neither of us wanted to end our relationship - I just needed more space. Being so close all the time was beginning to make me resent him. When I'm not around him all the time, I appreciate him and enjoy our time together more. This all makes such clear sense to me... but now after it's been several months, he is insisting we live together again. I have so enjoyed having my own home with my own rules. I have freedom, and I don't have any desire to use that freedom to cheat or find someone new. I love him and I want to maintain our relationship for the long term, and I know he feels the same way. I am happier with our relationship now than I have ever been in the past. I feel like I have the room to be the complete person I want to be... but if I say this to him, he interprets it as me wanting to be free to cheat on him. Neither of us are looking to get married and start a family. That doesn't mean I'm not committed to him. I don't want to end our relationship over this. I want to figure out how to help him understand how I feel. I'm tired of fighting over it. I can't seem to find any way to discuss it that doesn't end up with me sounding like I'm just selfish. This IS a selfish decision, but it's a logical one for our relationship too. If I don't have space to breathe, our relationship will never survive. I'm not going to relent. How do I talk to him about this?
How do I make my boyfriend understand (and respect) that I want to live alone?
Have an opinion?
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text:
- 发布:
- 2008-05-20
- 已更新:
- 2008-05-21
RHSA-2008:0297 - Security Advisory
Low: dovecot security and bug fix update
Security Advisory: Low
An updated dovecot package that fixes several security issues and various
bugs is now available for Red Hat Enterprise Linux 5.
This update has been rated as having low security impact by the Red Hat
Security Response Team.
Dovecot is an IMAP server for Linux and UNIX-like systems, primarily
written with security in mind.
A flaw was discovered in the way Dovecot handled the "mail_extra_groups"
option. An authenticated attacker with local shell access could leverage
this flaw to read, modify, or delete other users mail that is stored on
the mail server. (CVE-2008-1199)
This issue did not affect the default Red Hat Enterprise Linux 5 Dovecot
configuration. This update adds two new configuration options --
"mail_privileged_group" and "mail_access_groups" -- to minimize the usage
of additional privileges.
A directory traversal flaw was discovered in Dovecot's zlib plug-in. An
authenticated user could use this flaw to view other compressed mailboxes
with the permissions of the Dovecot process. (CVE-2007-2231)
A flaw was found in the Dovecot ACL plug-in. User with only insert
permissions for a mailbox could use the "COPY" and "APPEND" commands to set
additional message flags. (CVE-2007-4211)
A flaw was found in a way Dovecot cached LDAP query results in certain
configurations. This could possibly allow authenticated users to log in as
a different user who has the same password. (CVE-2007-6598)
As well, this updated package fixes the following bugs:
- configuring "userdb" and "passdb" to use LDAP caused Dovecot to hang. A
segmentation fault may have occurred. In this updated package, using an
LDAP backend for "userdb" and "passdb" no longer causes Dovecot to hang.
- the Dovecot "login_process_size" limit was configured for 32-bit systems.
On 64-bit systems, when Dovecot was configured to use either IMAP or POP3,
the log in processes crashed with out-of-memory errors. Errors such as the
following were logged:
pop3-login: pop3-login: error while loading shared libraries:
libsepol.so.1: failed to map segment from shared object: Cannot allocate
In this updated package, the "login_process_size" limit is correctly
configured on 64-bit systems, which resolves this issue.
Note: this updated package upgrades dovecot to version 1.0.7. For
further details, refer to the Dovecot changelog:
Users of dovecot are advised to upgrade to this updated package, which
resolves these issues.
Before applying this update, make sure that all previously-released
errata relevant to your system have been applied.
This update is available via Red Hat Network. Details on how to use
the Red Hat Network to apply this update are available at
- Red Hat Enterprise Linux Server 5 x86_64
- Red Hat Enterprise Linux Server 5 ia64
- Red Hat Enterprise Linux Server 5 i386
- Red Hat Enterprise Linux Workstation 5 x86_64
- Red Hat Enterprise Linux Workstation 5 i386
- Red Hat Enterprise Linux for IBM z Systems 5 s390x
- Red Hat Enterprise Linux for Power, big endian 5 ppc
- Red Hat Enterprise Linux Server from RHUI 5 x86_64
- Red Hat Enterprise Linux Server from RHUI 5 i386
- BZ - 238439 - CVE-2007-2231 Directory traversal in dovecot with zlib plugin
- BZ - 245249 - Dovecot hangs while using ldap backend.
- BZ - 251007 - CVE-2007-4211 Dovecot possible privilege ascalation in ACL plugin
- BZ - 253363 - Dovecot pop3-login/imap-login crash with OOM error
- BZ - 331441 - Please consider upgrading Dovecot to 1.0rc23 at least
- BZ - 380401 - tracker bug for 1.0.7 rebase
- BZ - 427575 - CVE-2007-6598: dovecot LDAP+auth cache user login mixup
- BZ - 436927 - CVE-2008-1199 dovecot: insecure mail_extra_groups option
Red Hat Enterprise Linux Server 5
|SHA-256: c8b5cce8b84dc8013c19261352a0f1e7d58abf7ca548df26697cb9f7331222e0
Red Hat Enterprise Linux Workstation 5
|SHA-256: c8b5cce8b84dc8013c19261352a0f1e7d58abf7ca548df26697cb9f7331222e0
Red Hat Enterprise Linux Server from RHUI 5
|SHA-256: c8b5cce8b84dc8013c19261352a0f1e7d58abf7ca548df26697cb9f7331222e0
Red Hat 安全团队联络方式为 email@example.com。 更多联络细节请参考 https://access.redhat.com/security/team/contact/。


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Today SimpliVity announced the rollout of two new hardware models optimized for remote office and branch office (ROBO) deployments: the OmniCube CN-1400 and the OmniStack Solution with Lenovo System x for Remote Sites. This extends our portfolio of ROBO platforms to include a wider range of options that span our entire portfolio of x86 platforms. ROBO deployments are one of the key drivers for customers adopting SimpliVity hyperconverged infrastructure. Enterprises of all sizes managing multiple remote offices are especially interested in a ROBO solution that help them simplify and consolidate their critical remote operations – from regional sales offices to retail outlets, manufacturing facilities, and more. Why is hyperconverged infrastructure ideal for ROBOs? Hyperconverged solutions natively combine compute, storage, and storage networking in single x86 building blocks, with rapid scalability within and across sites. SimpliVity goes even further by consolidating all IT … [Read more...]
SimpliVity Talks ROBO and VDI at Cisco Live Berlin
The SimpliVity team is finishing up Cisco Live in Berlin this week, discussing the various use cases that SimpliVity and Cisco address together with OmniStack. SimpliVity's OmniStack Solution with Cisco UCS is ideal for a wide variety of customer use cases, including data center consolidation, VDI, ROBO, data migration, private cloud, Tier-1 applications, data protection, and more. As a Cisco Preferred Solution Partner and Cisco TSANet Partner for support, SimpliVity has been taking the hyperconverged market by storm with its OmniStack solutions with Cisco. And now, we've been showcasing two of the hottest use cases for hyperconvergence at Cisco Live: remote office / branch office (ROBO) sites and virtual desktop infrastructure (VDI). ROBO Businesses are constantly adjusting their physical, worldwide presence to expand customer reach and foster growth. According to ESG, 53% of companies operate at least 100 ROBOs worldwide! More over, the 2015 State of Hyperconvergence Report … [Read more...]
Changing the Equation of ROBO Data Protection
Backing up and restoring the critical data and business applications in remote office/branch office (ROBO) locations has always been a challenge, especially when you don't have IT personnel in the distributed sites. With the ever-increasing volume of ROBO data—multiplied by dozens or more remote offices—you can imagine why IT organizations are looking for faster, more reliable, and more cost-effective ROBO data protection solutions. For ROBO backup and recovery, you have a few options: perform on-premises backup at the ROBO, perform a remote backup of ROBO data to a centralized location, or do nothing. Given the constraints of ROBO environments, the first two present real challenges. The third option of doing nothing only introduces risk to your organization. Let's examine each in more detail. Perform on-premises backup/recovery at the ROBO. An on-premises strategy at the ROBO location requires local backup/recovery software and hardware, and a method to get a copy off site for … [Read more...]
ROBO Tales from the Trenches
Halloween has ended and most of us can go back to living our day-to-day fright-free lives. The haunted houses have been closed down for the year. The ghosts and ghouls rising out of your neighbor's lawn will soon be replaced by an inflatable Santa Claus and his team of light-up reindeer. And, if you hurry, you might be able to snatch up some of the post-Halloween discount candy before it becomes full-priced Christmas candy. But while the rest of the world can look forward to the winter and the holidays it brings along, the scary season never seems to end for business owners with remote offices. That's because remote offices, when not running on the right IT infrastructure, can be very complex, very cumbersome, and very expensive to maintain. There are five main concerns keeping remote office managers up at night: data protection, physical footprint, management complexity, expense, and ability to scale. Data Protection Data loss. If you are in the IT industry and those two words … [Read more...]
Data Center in the Closet
Picture a closet at your favorite store. Just an ordinary closet. From the outside anyway. Imagine what's just beyond that closed closet door. If you turn the handle, what will you see? I picture dust particles floating in a dim room lit by a single ceiling light. A few yellow "Slippery When Wet" signs. A broom and a dustpan. Shelves, piled high with bottles full of blue-colored cleaning concoctions, paper towels, and trash bags. But this is no ordinary closet. This closet may foreshadow the future of IT, but for the moment it is an outlier, completely devoid of brooms and dustpans, of cleaning supplies, paper towels, "Slippery When Wet" signs, and trash bags. This closet is empty except for one or two appliances running the entire IT infrastructure of your favorite store along with network connectivity to the outside world. Businesses across the globe are finding that space is limited. There is just not enough room in every branch of a business to deploy a typical … [Read more...]
Extreme ROBO – Shape Up or Ship Out
Let's face it: there are so many conversations about ROBO today that they are all starting to sound a bit familiar and the challenges, commonplace. However, there are plenty of ROBO deployments that are far from commonplace. Just think of the extreme ROBO cases, where "remote" doesn't mean "not at headquarters" but rather hundreds of miles off the shore of Antarctica. Extreme ROBO cases have challenged IT teams to rethink how to design, build, and manage their infrastructure to serve the unique challenges for extremely remote areas that still need fast accessibility to business-critical applications. Whether extreme ROBO or standard ROBO, many enterprises are adopting hyperconverged infrastructure. Take one SimpliVity customer, one of the largest energy companies in the Southern Hemisphere – let's call them Oil & Gas Company (OGC for short)– who took remote to a whole new level when they deployed SimpliVity's OmniCubes on their ships 200 miles off-shore. OGC was faced … [Read more...]
Out of Sight Does Not have to Mean Out of Mind
Does your messy garage remind you of your ROBO's IT infrastructure? Is it like the dust under the couch? Do you find yourself wishing you could send it out with the recycling? Usually ROBOs (remote offices, branch offices) have neither the staff nor expertise on-site for supporting complex IT infrastructure and mission-critical, business applications. According to a recent ESG survey, only one in five ROBOs has on-site staff; that same study revealed over half (53%) operate at least 100 ROBO locations world-wide. Given the goals for which ROBOs are established – driving customer engagement and growing the business – supporting the business productivity of 'front-line' employees at these distributed locations must be on par with those working in corporate headquarters or centralized sites. Specifically, the infrastructure and application support must deliver high levels of performance and reliability. ROBOs may be out of sight to corporate IT, but in order to be successful … [Read more...]
Not all converged systems fit for ROBO
All IT admins understand the challenges and complications involved with launching or integrating remote or branch office (ROBO) IT. Nowadays many businesses are turning to pre-integrated or converged storage, servers and virtualization packages, and others even attempt to integrate best-of-breed components themselves, but these are not perfect solutions for ROBO. They do not address the lack of IT resources at ROBOs, and can actually perpetuate WAN bandwidth inefficiencies and bottlenecks. Do-it-yourself (DIY) solutions always end up taking more time and resources than anticipated; resources that must continue to be applied for on-going upgrades, integrations and support. And for ROBOs, replicating a DIY approach across multiple locations with little or no local IT support is a risky proposition. Pre-integrated storage, servers and virtualization packages also do not address the limited IT resources at distributed locations. And their design does nothing to address the increasing … [Read more...]
Taking the Remote out of ROBO
Sir Richard Francis Burton once said: "Little islands are all large prisons: one cannot look at the sea without wishing for the wings of a swallow." No I am not here to philosophize, but when people talk of Remote Office Branch Office (ROBO) they do sometimes refer to them as Islands of ROBO. Why is that? Well the ROBO is often like an Island in the stream, left out of the sidelines, under-staffed, under-budget and under-supported. Islanders need to be a tough bunch because they face may unique challenges and routine shortages. They are the poster children of "doing more with less". They have to deal independently with the challenges of being remote. Like Islanders, ROBO administrators face many challenges. Maintaining, managing, protecting and securing a multi-vendor legacy IT infrastructure is difficult. Today's ROBO environments need to be dynamic and keep pace with shifting business requirements, however, with limited specialized IT staff, and constrained IT budgets many … [Read more...]


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Toyota Motor Philippines Corp. plans to invest an additional 3.3 billion Philippines peso ($58.8 million) for plant expansion and modernization in the next two years to realize its goal of becoming a major player in the global automotive industry. At the same time, the company's parts-manufacturing arm, Toyota Autoparts Philippines Inc., expects to export more than PP23 billion($400 million) by 2005, according to a published report. Last year, the Toyota Philippines group ...
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Exercise stress is associated with increased risk for upper respiratory tract infection. We have shown that exercise stress can increase susceptibility to infection. Quercetin, a flavonoid present in a wide variety of fruits and vegetables, has been reported to inhibit infectivity and replication of a broad spectrum of viruses and may offset the increase in susceptibility to infection associated with stressful exercise. This study examined the effects of quercetin feedings on susceptibility to the influenza virus A/Puerto Rico/8/34 (H1N1) following stressful exercise. Mice were randomly assigned to one of four treatment groups: exercise-placebo, exercise-quercetin, control-placebo, or control-quercetin. Exercise consisted of a run to fatigue (∼140 min) on a treadmill for 3 consecutive days. Quercetin (12.5 mg/kg) was administered via gavage for 7 days before viral challenge. At 30 min after the last bout of exercise or rest, mice (n = 23–30) were intranasally inoculated with a standardized dose of influenza virus (0.04 hemagglutinating units). Mice were monitored daily for morbidity (time to sickness), symptom severity, and mortality (time to death) for 21 days. Exercise stress was associated with an increased susceptibility to infection [morbidity, mortality, and symptom severity on days 5–7 (P < 0.05)]; quercetin offset the increase in susceptibility to infection [morbidity, mortality, and symptom severity on days 5–7 (P < 0.05)] that was associated with stressful exercise. These data suggest that short-term quercetin feedings may prove to be an effective strategy to lessen the impact of stressful exercise on susceptibility to respiratory infection.
- nutrition
- mice
- infection
- stress
- virus
several studies have reported that exercise can alter many immune system components and, therefore, modulate susceptibility to infection. It has been hypothesized that exercise stress can increase the risk for upper respiratory tract infection (URTI); data from controlled experimental animal studies generally support this hypothesis (5, 6, 11, 13, 19, 22), although there is some controversy regarding the supporting evidence in human subjects (4). There is very little evidence of the effects of exercise stress on susceptibility to the principal etiological agents of human respiratory infections, including influenza viruses. Our laboratory has used a herpes simplex virus (HSV-1) and an influenza [A/Puerto Rico/8/34 (H1N1)] mouse model of respiratory infection to determine the effects of exercise stress on susceptibility to infection (5, 6, 11, 13). We have reported that exercise stress can increase susceptibility to HSV-1 and influenza infection [morbidity (time to sickness), symptom severity, and mortality (time to death)] (5, 6, 11, 13), which are associated with a decrease in macrophage antiviral resistance (11, 13). The effects associated with exercise stress are not unlike those that have resulted in other stress paradigms, such as psychological stress, which has been shown to alter infectivity of a variety of pathogens, including HSV-1 and influenza (2, 18, 34).
Various nutritional strategies, including β-glucan (13), carbohydrates (26, 28), glutamine (7), zinc (30), and antioxidants (29), have been investigated as possible countermeasures for immunosuppression during periods of stressful training and competition. Several of these strategies have been shown to alter many immune system components during periods of stressful exercise (13, 26, 28, 30). However, except for a beneficial effect of oat β-glucan on susceptibility to HSV-1 infection following exercise stress (13), there is little evidence to suggest that these or any other nutritional strategies produce clinically significant changes in susceptibility to infection (23).
Quercetin, a flavonoid present in a wide variety of fruits and vegetables, has been investigated for its antiviral activity. Cell culture studies have shown that quercetin can reduce infectivity of target cells and replication against a wide variety of respiratory viruses, including HSV-1 and HSV-2 (9, 14), adenoviruses (AdV-3, AdV-8, and AdV-11) (9), coronavirus (14), parainfluenza virus type 3, respiratory syncytial virus (20), rhinovirus (15), and severe acute respiratory syndrome (8). It has recently been reported that quercetin feedings can reduce URTI following 3 days of exhaustive cycling exercise in athletes (27). However, the effects of quercetin on susceptibility to infection following exercise stress in a controlled experimental viral challenge model have not been determined.
The purpose of the present study was to determine the effects of quercetin feedings on susceptibility to infection following stressful exercise in mice. Altered susceptibility to infection was measured as changes in morbidity (time to sickness), symptom severity, and mortality (time to death). This was done using a well-characterized murine model of exercise stress (5, 6, 11, 13) and respiratory infection (5, 6, 11–13, 24). The exercise protocol consisted of 3 consecutive days of prolonged treadmill running to fatigue designed to mimic a short period of severe exercise training. The virus used to induce respiratory infection, the influenza virus A/Puerto Rico/8/34 (H1N1), was administered after the 3 days of exercise stress. There is a lack of evidence of the effects of exercise stress or nutrition on influenza virus infection, one of the most common human respiratory viruses among military personnel and athletes. Furthermore, because there is no virus challenge pool for influenza virus infection studies in humans, animal models are the only tool to examine exercise and nutritional effects on susceptibility to influenza virus infection. Quercetin was used because of its documented widespread health benefits, which include antiviral activity, abundance in the diet, and reported lack of side effects when used as a dietary supplement or food additive (17). We hypothesized that quercetin would offset the exercise stress-induced increase in susceptibility (morbidity, symptom severity, and mortality) to influenza virus.
Four-week-old male ICR mice (Harlan Sprague Dawley Labs) were acclimated to our facility for ≥3 days before any experimentation. Mice were purchased as pathogen-free stock, and periodic screening of sentinel mice yielded negative results for common murine viral or bacterial pathogens. Mice were housed, five per cage, and cared for in the animal facility at the University of South Carolina School of Medicine. Mice were maintained on a 12:12-h light-dark cycle in a low-stress environment (22°C, 50% humidity, low noise) and given food (Purina chow) and water ad libitum. All experiments were performed at the beginning of the active dark cycle. Animals were removed from the experiment if they refused to run on the treadmill, did not survive the inoculation, or expelled the inocula by sneezing. Typically, in our hands, this results in elimination of <10% of animals. The Institutional Animal Care and Use Committee of the University of South Carolina approved all experiments.
Quercetin treatment.
Mice were randomly assigned to one for four treatment groups as follows: exercise-placebo (Ex-Plac, n = 23), exercise-quercetin (Ex-Q, n = 27), control-placebo (Con-Plac, n = 30), or control-quercetin (Con-Q, n = 29). Quercetin (12.5 mg/kg; catalog no. QU995, Quercegen Pharma, Newton, MA) was fed to the mice via gavage daily in 200 μl of Tang (Kraft Foods, Northfield, IL) for the 7 days before viral challenge. Quercetin was administered in Tang, which contains vitamins (especially B3 and C) that have been suggested to increase the bioavailability of quercetin (personal communication, Quercegen Pharm). The placebo groups received Tang only during this time. The dose and timing of quercetin administration were based on evidence from our laboratory involving other effects of quercetin in rodents (unpublished data).
Treadmill acclimation and exercise protocol.
The Institutional Animal Care and Use Committee of the University of South Carolina approved the protocol. The exercise groups were acclimated to the treadmill for 20 min/day for the 3 days before the experimental exercise bouts. The exercise protocol consisted of an exhaustive exercise bout of treadmill running (performed in the evening, at 6 PM) for 3 consecutive days. Mice in the exercise groups ran on the treadmill (2 per lane) at 36 m/min and 8% grade until they reached volitional fatigue. Fatigue was defined as the inability of the mouse to maintain the appropriate pace, despite continuous hand prodding for 1 min, at which time the mouse was removed from the treadmill. Electric shock was never used, inasmuch as mice readily respond to a gentle tap of the tail or hindquarters encouraging them to maintain pace with the treadmill. Mice rarely required this type of continual prodding until they approached the point of fatigue. The control groups remained in their cages in the treadmill room throughout the exercise bouts; they were exposed to similar handling and noise in an attempt to control for extraneous stresses that may be associated with treadmill running. The control groups were deprived of food and water during the exercise sessions.
Intranasal infection with influenza.
On the day of the experiment, mice were exposed to control treatment or exercise. Immediately after exercise or control treatment, mice were given their final quercetin or placebo treatment and were returned to their cages; 30 min later they were lightly anesthetized with isoflurane and inoculated intranasally with 50 μl of a standardized dose (0.04 hemagglutinating units) of influenza virus [A/Puerto Rico/8/34 (H1N1)]. This dose yielded a ∼50% mortality rate among control mice in preliminary dose-response experiments. After infection, the mice were returned to their respective cages and housed in an isolated BSL-2 (Biosafety level 2) facility. All animals were monitored daily for 21 days for signs of morbidity, symptom severity, and mortality by an investigator blinded to the treatments.
Measures of morbidity.
Several typical symptoms of illness, including ruffled fur, redness around the eyes, nose, or mouth, altered respiration, hunched-back pose, and unresponsiveness, were included in the symptom severity scale (Table 1). Animals were scored daily on the basis of symptoms; each symptom was given a score of 1–3 depending on its severity. Symptoms that generally appear at the onset of sickness (ruffled fur and redness around the eyes) were weighted less than symptoms that appear as the illness became more severe (hunched-back pose, altered respiration, and unresponsiveness). In this model, symptoms such as ruffled fur and redness around the eyes will appear first (days 4–5) followed by altered respiration and a "hunched-back" pose (days 5–6); mice that are severely ill will be unresponsive (after day 6). Mice that displayed any of these sickness symptoms were considered morbid. Cumulative scores ranged of 0–9 were based on the varying degree of symptoms of sickness.
Statistical analysis.
Statistical analyses were performed using a commercially available statistical package (version 2.03, SigmaStat, SPSS, Chicago, IL). Differences in morbidity (time to sickness) and mortality (time to death) between groups across the 21-day postinfection period were determined using the Lifetest Survival Analysis program in SigmaStat (P < 0.05), which reported mean and median time to sickness and death. Differences in symptom severity over the 21-day postinfection period were determined using a two-way analysis of variance (exercise × treatment) with Student-Newman-Keuls post hoc analysis (P < 0.05).
We examined the effects of quercetin on morbidity rates in mice after a controlled viral challenge with influenza virus and exercise stress. Morbidity is defined as day 1 of onset of sickness symptoms. Group differences in morbidity were evident over the 21-day postinfection period (Fig. 1). Intranasal administration of influenza virus following 3 days of exercise stress resulted in an increase in morbidity (i.e., time to sickness) compared with resting controls (P < 0.001); mean time to sickness was 6.9 ± 0.7 (SE) days for Ex-Plac and 12.4 ± 1.4 days for Con-Plac. Median time to sickness (50% percentile) was 6.0 ± 0.19 days for Ex-Plac and 7.0 ± 0.6 days for Con-Plac. Ex-Plac experienced a 91% incidence in morbidity, while only 63% of Con-Plac got sick. Quercetin feedings for 7 days before infection significantly offset the increase in morbidity associated with stressful exercise (P < 0.01); mean time to sickness was 11.6 ± 1.5 days, and median time to sickness was 7.0 ± 0.35 days. Incidence of morbidity was 67% in Ex-Q. There was no difference between Ex-Q and Con-Plac and between Con-Plac and Con-Q.
Symptom severity.
Sickness symptoms were also graded to better address possible differences in severity of sickness (Table 1). Morbidity data simply indicate the day on which the first symptom was observed. Symptom severity data for days 1–7 (until and including death) after infection is presented in Fig. 2. Symptom scores are only reported to day 7, because as animals with very high symptom scores die, the mean scores for the living animals are artificially reduced, which could be inappropriately interpreted as recovery. In fact, very few animals recover once they become sick. Symptom severity was significantly different across the groups. The symptom severity score was significantly higher for Ex-Plac than Con-Plac on days 5–7 (P < 0.05). However, quercetin feedings significantly offset the increased symptom score in Ex-Q on days 5–7 (P < 0.05). There were no differences in Con-Plac vs. Ex-Q and Con-Q.
Similar treatment effects were found for mortality (i.e., time to death) over the 21-day postinfection period (Fig. 3). Intranasal administration of influenza virus following 3 days of exercise stress resulted in a significant increase in mortality compared with resting controls (P < 0.05): mean time to death was 12.5 ± 1.3 days for Ex-Plac and 15.9 ± 1.2 days for Con-Plac. Median time to death (50% percentile) was 9.0 ± 0.33 days for Ex-Plac and 14.0 days for Con-Plac. Mortality was 74% in Ex-Plac compared with 50% in Con-Plac. Quercetin feedings for 7 days before infection significantly offset the increase in mortality associated with stressful exercise (P < 0.01): mean time to death was 16.5 ± 1.2 days and median time to death was 20.0 days. Mortality in Ex-Q was only 52%. There was no difference between Ex-Q and Con-Plac. There was, however, a trend toward a beneficial effect of quercetin in Con-Q (P = 0.08): mean time to death was 18.5 ± 1.1 days, and median time to death is not reported, inasmuch <50% of mice exhibited mortality. Mortality in Con-Q was only 28%.
Various nutritional strategies, including zinc and Echinacea, have been examined for their ability to enhance immune function and decrease susceptibility to infection. However, there is little evidence to suggest that these or any other nutritional strategies produce clinically significant changes in susceptibility to infection in healthy, nonimmunocompromised subjects (31, 32). Furthermore, evidence of a possible benefit of nutrition in offsetting the increased risk for respiratory infection that is associated with exercise stress is limited. Quercetin, a flavonoid, has been reported to have widespread health benefits (17), including antiviral activity (9, 14). Recent evidence has shown that quercetin feedings can reduce illness symptoms following 3 days of exhaustive cycling exercise (27); however, the results of this study were based on self-reported symtomatology, and there was no attempt to identify the pathogenic origin. The present study used an established model of exercise and respiratory infection to determine whether quercetin feedings could protect mice from influenza virus infection following 3 days of exercise stress. The data suggest that quercetin feedings can offset the exercise stress-induced increase in morbidity (time to sickness), symptom severity, and mortality (time to death) in mice after intranasal inoculation with a standardized dose of influenza virus [A/Puerto Rico/8/34 (H1N1)]. We also found a trend toward a decrease in susceptibility to infection in rested nonstressed mice after quercetin treatment.
Data from controlled animal studies have been important in determining the effects of exercise stress on susceptibility to respiratory infection. However, evidence of the effects of exercise stress on influenza virus, one of the most common respiratory viruses among soldiers and athletes, is still limited. The specific pathogenesis and symtomatology of influenza infection are well characterized in the literature (3). Several studies have used this model to determine the effects of exercise on susceptibility to infection and possible immune mechanisms (19, 21, 22). The results from this study indicate that 3 days of exhaustive exercise on a treadmill can increase susceptibility to influenza virus [A/Puerto Rico/8/34 (H1N1)] infection and are consistent with our previous findings and those of others. For example, exhaustive swimming resulted in a 33% increase in mortality following infection with influenza virus [A/Aichi/2/68 (H3N2)] (19), and prolonged treadmill running resulted in higher maximal morbidity scores following infection with influenza virus [A/Puerto Rico/8/34 (H1N1)] (22).
Quercetin has been reported to reduce infectivity of target cells and replication against a wide variety of respiratory viruses (8–10, 14, 15, 20). It has been shown to decrease multiplication and infectivity of several etiological agents of respiratory infection, including HSV-1 and HSV-2 (9, 14), AdV-3, AdV-8, and AdV-11 (9), coronavirus (14), parainfluenza virus type 3, respiratory syncytial virus (20), rhinovirus (15), and severe acute respiratory syndrome (8), in cell culture studies. Recent evidence in athletes shows that quercetin feedings can reduce self-reports of upper respiratory infection following 3 days of exhaustive exercise (27). Cyclists ingesting quercetin at 1,000 mg/day over a 3-wk period experienced a significantly lower incidence of infection during the 2-wk period following the intense exercise. It is important, however, to note that this was based on self-report of upper respiratory infection with no confirmation of viral illness. To our knowledge, these are the first data to show a benefit of quercetin on the exercise-induced increase in susceptibility to respiratory infection in a controlled experimental virus challenge model. This is especially important given that there is no influenza virus challenge pool for use in human subjects.
Our findings also indicate a potential benefit of quercetin in rested, nonstressed control mice, but this effect did not reach statistical significance. However, in studies such as this, it is not unusual to find a lack of effect in healthy nonstressed animals that becomes significant in immunosuppressed or stressed individuals. Furthermore, the present study was designed to examine a benefit of quercetin in exercise-stressed mice and the lethal dose was determined based on this purpose. It is certainly possible that the strong trend toward a benefit of quercetin on susceptibility to infection in rested, nonstressed mice may become significant if the viral dose was adjusted.
The precise mechanisms for the apparent beneficial effect of quercetin on susceptibility to infection following exercise stress are unknown. However, previous evidence suggests multiple possible mechanisms for the antiviral effects of quercetin. Cell culture studies have reported that quercetin can block viral replication at an early stage of multiplication for several respiratory viruses, including adenoviruses, coronaviruses, and rhinoviruses, and using several mechanisms, including inhibition of proteases by molecular docking, suppression of virulence enzymes such as DNA gyrase and cellular lipase, and binding of viral capsid proteins (8–10). It is also possible that quercetin's antiviral effects may be mediated through induction of interferon; quercetin induces the gene expression and production of helper T lymphocyte-1 (Th-1)-derived IFNγ, and it downregulates Th-2-derived IL-4 when cultured with human peripheral blood mononuclear cells (25). Studies have also reported that quercetin may enhance activity of a variety of immune system components. Data from in vitro and animal studies have shown that quercetin increases natural killer cell lytic activity, neutrophil chemotaxis, and mitogen-stimulated lymphocyte proliferation (1, 16, 25). Nieman et al. (27) examined the effects of quercetin feedings on immune system dysfunction following 3 days of prolonged cycling and reported no beneficial effects of quercetin on natural killer cell lytic activity, polymorphonuclear respiratory burst, or phytohemagglutinin-stimulated lymphocyte proliferation, despite the reduced incidence of upper respiratory tract infection symptoms following quercetin feedings. However, many immune system parameters that have been shown to play a role in susceptibility to respiratory infection following exercise stress could not be measured in that study, for example, lung macrophages, which have been shown to play a necessary role in elimination of virus following respiratory infection.
One of the findings of the present study suggests that short-term quercetin feedings before infection (i.e., primary prevention) can delay the onset of sickness following intranasal inoculation of the virus. Although it is easy to conclude, therefore, that quercetin protected the animals from infection, it is also possible that this was due to reduced inflammation, which would be expected to blunt the symptoms. Indeed, quercetin is known to have potent anti-inflammatory properties (17). Both of these outcomes would be considered positive responses to quercetin feeding, especially in this case, since overall morbidity and mortality were benefited by quercetin. However, in certain cases, a more rapid appearance and resolution of symptoms may be a more favorable outcome. It is important to note that a quercetin-induced reduction in inflammatory processes may not always result in a reduction in susceptibility to infection; it has been shown that inflammation is necessary for the efficient elimination of influenza virus infection (33). This is clearly an aspect that should be considered in future studies in which the dose and timing of quercetin administration in relation to virus challenge are investigated.
In conclusion, this is the first controlled experimental study to show a benefit of short-term quercetin feedings on susceptibility to respiratory infection following exercise stress. Quercetin feeding was an effective preventive strategy to offset the increase in susceptibility to infection (morbidity, symptom severity, and mortality) that was associated with stressful exercise. If our data can be clinically translated, they may lead to an important nutritional strategy to decrease the risk of infection, which can be a problem in athletes and military personnel, who are often exposed to combinations of severe physical, psychological, and environmental stress.
This study was supported by Defense Advanced Research Projects Agency Award W911NF-07-10140.
The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
- Copyright © 2008 the American Physiological Society


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Decorating By Mamacitadedos Updated 25 Mar 2009 , 12:12pm by Mamacitadedos
Hi everyone. I'm new to the site and could not find any topics that would help me with my problem. So here goes...
On Mother's Day this year (so in about a month & a half) my husband and I will be participating at a Dedication Ceremony for our 5 1/2 year old son and 1 1/2 year old daughter. We plan on having a party in honor of the occassion with their GodParents and other family and close friends. All together there will be about 20-25 people, including us. I know I'm going to be making a cake for the occassion, and yes decorating it (which I've been doing here and there for about 8 years so I kinda know what I'm doing but not totally). I'm drawing a total blank for a cake idea. It will probably be chocolate since that is my son's favorite kind (and well my daughter has Mommy's sweet tooth so isn't picky). I don't want to just do a cross since it's not an actual baptism. Any ideas would be absolutely lovely and welcomed. Thanks for the help.
Hi there and welcome to our sweet little corner of the internet
Since you do have a bit of time I suggest you check out our galleries. There are sooooo many ideas to choose from. The topic for you to look at is Baby Showers.......and there are 2 or 3 separate places to find them. Christening/Baptism cakes are included in those areas.
Thanks for the welcome & the idea.
Don't know why it didn't occur to me to take a look at the gallery.
That should be a big big help.


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Best Practices for Setting Up a Global International Trade Compliance Program
Product ID: 703708
- Duration: 60 Min
Customer Care
Fax: +1-650-565-8542
Email: firstname.lastname@example.com
In this webinar, the speaker will share proven best practices on how to create, evaluate and monitor a global trade compliance program. The speaker will share critical components that should be included in your global compliance plan, and discuss specific actions for each component.
Why Should You Attend:
In today's global economy, multinational companies have business partners, employees, subsidiaries and offices around the world. As a trade compliance profession, you may be responsible for trade compliance at your organization on a global level. This is a challenging task.
Although you may have a good grasp on trade compliance activities within the USA, you could still be looking for answers to these questions:
- How do you evaluate the trade compliance risk for your worldwide subsidiaries?
- How do you ensure that your worldwide subsidiaries are adequately managing their trade compliance risk?
In this webinar, the speaker will address questions on how to create, evaluate and monitor a global trade compliance program. He will provide guidelines to help you create and maintain a successful trade compliance program focusing on international controls. In particular, the speaker will discuss critical import/export compliance components and benchmarking suggestions.
Areas Covered in the Webinar:
- Benefits: Learn why it is important to have a trade compliance program that covers your worldwide operations.
- Risks: Examples where lack of a coordinated trade compliance program cost companies millions.
- Challenges: Understand the common challenges in setting up a global trade compliance program.
- Best Practices: How do the best-run companies manage trade compliance in multiple geographies?
- Benchmarking: Learn about a scorecard method will help identify global risk areas.
- Import Topics: What are the import components that need to be included in a global compliance program?
- Export Topics: What are the export components that need to be included in a global compliance program?
- Roll-out: Recommendations on rolling out this program globally.
- Monitoring: Suggestions for monitoring your company's global trade compliance program going forward.
Who Will Benefit:
- Global Trade Compliance Professionals
- Import/Export Compliance Personnel
- Tax & Accounting Department
- Legal Department
- International Purchasing and Logistics Managers
- Customs Brokers
Deep SenGupta is the president of DSG Global, LLC, where his mission is to simplify global trade for his customers. Over the past 12 years, Mr. SenGupta co-founded and led FedEx's Trade & Customs Advisory Services (TCAS) division and assisted over 1000 importers and exporters with international trade solutions. In this capacity, he travelled to several companies to help his US-based customers develop worldwide trade compliance programs.
Prior to joining FedEx, he was with KPMG's Asia Pacific tax practice from 1997 where he helped establish KPMG's international trade and customs practice in India and advised several Fortune 500 clients on market-access issues for their South-Asian operations.
Mr. SenGupta obtained his basic legal training (LL.B) in India and then obtained a Masters in Law-Taxation (LL.M) from the University of Washington - School of Law (2001) in Seattle, WA. He has also received executive education on international trade from Harvard University's Kennedy School.
He was appointed by the U.S Secretary of Commerce to the President's Export Council Subcommittee on Export Administration (PECSEA) to advise the Obama administration on its export control reform efforts. He has also assisted the CBP by serving on a COAC working group on enhancements to the focused assessment program. Mr. SenGupta is a sought-after speaker on international trade issues and addresses customers and trade associations around the country.
Topic Background:
Around the world, many individual countries (for example: China, India, Brazil, etc.) are getting increasingly diligent about trade compliance. For multinationals headquartered in the United States, this means that trade compliance professionals need to manage their risk on a worldwide basis, not just in the USA. This leads to a real challenge for the managers of a global trade compliance program, as they need to create international controls, processes, manuals and manage local trade compliance teams across dozens of jurisdictions.
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- asleep
- I. adjective Etymology: Middle English aslepe, from Old English on slæpe Date: 13th century 1. being in a state of sleep 2. dead 3. lacking sensation ; numb 4. a. inactive, dormant b. not alert ; indifferent II. adverb Date: 13th century 1. into a state of sleep 2. into the sleep of death 3. into a state of inactivity, sluggishness, or indifference
New Collegiate Dictionary. 2001.


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Question: List and describe several issues that pertain to each stage
List and describe several issues that pertain to each stage of the project life cycle.
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Answer to relevant QuestionsPut the five project management process groups in order from the one that generally requires the least work to the one that requires the most. Why might a contractor company perform a SWOT analysis prior to bidding on a potential project? Complete the following scoring model. Show all your work. Tell which project you would pick first, second, third, and last. How confident are you with each choice? If you lack confidence regarding any of your choices, what ...What are organizational values and what can a project manager accomplish with them? Given a scenario, select a preferred organizational structure and justify your selection.
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text: Siemens VersaCell X3 Solution (Photo: Business Wire)"Automation is essential to Martin Health System's laboratory operations, helping staff optimize workflow, consistently achieve quality measures and deliver superior service to the physician community we support," said Janet Frankenbery, BS, MT(ASCP) DLM, Corporate Director, Laboratory Services, Martin Health System. "As longtime users of several Siemens laboratory automation solutions, including multiple VersaCell systems, we are excited about the introduction of VersaCell X3 Solution and the additional benefits this advanced automation platform is positioned to deliver." Staffing challenges and widening access to medical care pushing testing volumes higher are increasing pressure on clinical laboratories to streamline operations and prepare for the future. ³ For lower- and mid-volume labs, whose budgets are often particularly constrained and where track-based automation may not be the right approach, VersaCell X3 Solution delivers several advantages. The new platform maintains its small footprint and upright design, but now connects up to three Siemens analyzers through a single robotic sample interface for increased productivity gains. ⁴ By supporting a customized mix of chemistry, immunoassay and/or integrated systems and associated assay menus, VersaCell X3 Solution helps labs reduce operator sample handling, better prioritize staff work and eliminate pre- and post-analytical processing—all through one-touch sample management. A conveniently placed priority drawer on VersaCell X3 Solution, situated above existing routine sample drawers, provides eight new STAT positions and frees up 50 sample positions for routine processing, enhancing STAT management and increasing overall sample routing flexibility. Plus, modifications to VersaCell X3 Solution's signature robotic arm also enable it to support both rounded and flat-bottom tubes, and the incorporation of a docking plate reduces service intervention time for all connected systems, increasing uptime so that labs can continue to deliver results to clinicians on time. A centralized screen on VersaCell X3 Solution provides consolidated, single-operator access to all connected analyzers, and further data consolidation is achievable through a connection to Siemens' CentraLink™ Data Management System.


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Signed up for my CWP class!!!
I'm finally taking my CWP class June 15th! I can't wait!! I'm still undecided on what to qualify with the g19c or the g22? Any suggestions? They're both pretty comfortable to shoot and I don't really notice any difference in the two to be honest. I also think they're both pretty easy to conceal.
Manta - it depends on the state. here in Pennsylvania(PA), open carry is legal, however, I've only seen it once or twice, always out in the wilds. PA is a "shall issue" state, meaning that if you are not barred by law from owning a firearm, it must issue you a concealed carry permit(CCW) that is valid for 5 years. You must apply for your CCW through the county sherriff's office and you are finger printed and photographed and must carry you CCW with you when you carry a concealed deadly weapon.
In order to CC in 36 other states, I had to take a 4 hour class, and submit another set of fingerprints and a photo to the issuing state (Utah). There is an approximately 60-day waiting period, while Utah officials do a background check.
Missoura, I was gonna ask that. Smaller is better to carry -- less so to qualify if they even test live there in SC.
Yeah I was living in Missouri and should have taken it then. Working too much and nights I just never got around to it. All they told me was bring what ever pistol I wanted and 50 rounds, it's an all day class. I could open carry in Missouri but only in certain cities. I did open carry a few times but only when I was in the city picking up my wife from work. I'm considering getting the g30s. I'm a big fan of the .45 and its supposed to be a slim frame design. The way my body is, it's not uncomfortable for me to keep a glock or my H&K usp compact which got stolen last year on the right side of my back/hip. The waiting period is at least 6 months right now and they just upped the fee to $75. The class is $50+$5 for fingerprinting, so I'm looking at around $130 after it's all said and done and the permit is good for 3 years. I'm not sure what the renewal is. I think it's easier to purchase after getting your CWP so I've heard.
Differs from state-to-state...in Florida, for example, you don't have to take a class if you have proof of prior firearms training, such as the military. It's never about proficiency. That you have to learn on your own. It's mostly about safety and the laws pertaining to CC, etc.
If you are not proficient in holstering and deploying your Glock, get in lots of practice with an unloaded Glock. Every weekend, some guy gal does an unintentional discharge of their handgun, because sometimes fingers get a crossed signal.
Do not to get Glock leg at the range on class day.
Be careful!
Yea I'll be careful. As a habit I never put my finger on the trigger unless I'm ready to fire. I've practiced some drills getting my weapon out as fast as I can. I'm looking forward to it though I think it will be a good experience.
Alright I got bumped up on the class I found out yesterday and took my test today. Passed shooting test with 100% and missed two questions that were south carolina related. The gun safety and common sense I obviously got correct. I'm sending my paperwork next friday and then will just wait on my permit for the next 3 months :(
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text: Net sales per hectoliter increased 1 percent in local currency. Owned brand net sales per hectoliter were in line with last year as a result of higher on-premise pricing and favorable mix, offset by lower pricing in the off-premise.COGS per hectoliter increased nearly 5 percent in local currency, driven by input inflation, higher pension expense, cycling a reduction in employee incentive compensation last year and fixed-cost deleverage from lower volumes, partly offset by results of cost savings initiatives. MG&A expenses increased 5 percent in local currency, due to cycling a reduction in employee incentive compensation last year, partly offset by cost savings. International Business The International segment posted an underlying pretax loss of $7.7 million in the third quarter, up from a $7.2 million loss a year ago due to incremental brand investments, partially offset by year-over-year volume growth from Europe and Latin America markets and including Central Europe export results this year. The Central Europe export business contributed underlying pretax income of $2.8 million in the third quarter. International STRs more than doubled due to the addition of Central Europe export. Excluding the addition of Central Europe export, STRs increased nearly 14 percent, driven by Carling growth in our Europe export markets, Coors Light growth in Latin America, Zima and Modelo brands in Japan, and a full quarter of sales in India this year. Net sales revenue increased 38.3 percent on higher volumes with 21.5 percent attributable to the inclusion of Central Europe export. COGS per hectoliter decreased 5.8 percent driven by geographic mix, partially offset by the inclusion of Central Europe export. Excluding the addition of Central Europe export, COGS per hectoliter decreased 16.9 percent. International MG&A expense increased 30.2 percent, driven by incremental brand investments in priority markets. Corporate Underlying Corporate expenses totaled $67.2 million pretax for the third quarter. This increase of $16.3 million was due to $22.4 million of interest expense related to financing our Central Europe acquisition this year.


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