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Breast ductal lavage for biomarker assessment in high risk women: rationale, design and methodology of a randomized phase II clinical trial with nimesulide, simvastatin and placebo
Clinical and radiation oncology
Despite positive results from large phase III clinical trials proved that it is possible to prevent estrogen-responsive breast cancers with selective estrogen receptor modulators and aromatase inhibitors, no significant results have been reached so far to prevent hormone non-responsive tumors. The Ductal Lavage (DL) procedure offers a minimally invasive method to obtain breast epithelial cells from the ductal system for cytopathologic analysis. Several studies with long-term follow-up have shown that women with atypical hyperplasia have an elevated risk of developing breast cancer. The objective of the proposed trial is to assess the efficacy and safety of a daily administration of nimesulide or simvastatin in women at higher risk for breast cancer, focused particularly on hormone non-responsive tumor risk. The primary endpoint is the change in prevalence of atypical cells and cell proliferation (measured by Ki67) in DL or fine needle aspirate samples, after 12 months of treatment and 12 months after treatment cessation.
From 2005 to 2011, 150 women with a history of estrogen receptor negative ductal intraepithelial neoplasia or lobular intraepithelial neoplasia or atypical hyperplasia, or unaffected subjects carrying a mutation of BRCA1 or with a probability of mutation >10% (according to BRCAPRO) were randomized to receive nimesulide 100mg/day versus simvastatin 20mg/day versus placebo for one year followed by a second year of follow-up.
This is the first randomized placebo controlled trial to evaluate the role of DL to study surrogate endpoints biomarkers and the effects of these drugs on breast carcinogenesis. In 2007 the European Medicines Agency limited the use of systemic formulations of nimesulide to 15 days. According to the European Institute of Oncology Ethics Committee communication, we are now performing an even more careful monitoring of the study participants. Preliminary results showed that DL is a feasible procedure, the treatment is well tolerated and the safety blood tests do not show any significant liver toxicity. There is an urgent need to confirm in the clinical setting the potential efficacy of other compounds in contrasting hormone non-responsive breast cancer. This paper is focused on the methodology and operational aspects of the clinical trial.
Trial Registration
(ClinicalTrials.gov Identifier: NCT01500577)
Breast cancer (BC) is now the most common cancer diagnosed in women worldwide and is the leading cause of deaths from cancer among women
Several studies with long-term follow-up have shown that women with atypical hyperplasia have an elevated risk of developing breast cancer
The ductal lavage (DL) procedure offers a minimally invasive method to obtain breast epithelial cells from the ductal system for cytopathologic analysis to provide individualized risk assessment with a sensitivity up to 3.2 times greater than that of Nipple Aspirate Fluid (NAF) in detecting abnormal intraductal cells
Over-expression of cyclooxygenase-2 (COX-2) has been detected in a variety of human tumors in breast, prostate, lung, skin, and colon
Statins (HMG-CoA reductase inhibitors), the most widely used medications in the western world to manage hypercholesterolemia and associated morbidities
All these data, together with the long post-marketing surveillance of both compounds, make these two drugs most interesting to investigate in a chemoprevention trial in subjects at higher risk for ER negative breast cancer.
We are conducting a phase II, randomized, double blind, placebo controlled trial in 150 women at increased risk for hormone non-responsive breast cancer, randomly assigned to receive nimesulide 100 mg or simvastatin 20 mg once daily or matching placebo for 12 months, and then followed for another year. This paper describes the rationale and design of the study, thus focusing on the methodology and operational aspects of the clinical trial.
Ethical considerations and registration
The study protocol is in compliance with the Declaration of Helsinki
Design overview
We are conducting a monoistitutional phase II, randomized, double blind, placebo controlled trial to assess the efficacy and the safety of a daily administration of nimesulide or simvastatin to change the expression of a large set of tissue and circulating surrogate endpoint biomarkers (SEBs) of breast carcinogenesis in women at higher risk of developing a hormone non-responsive (ER negative) breast cancer. The primary endpoint is the change in prevalence of atypical cells and cell proliferation (Ki-67), after 12 months of treatment. A total of 150 women were randomized: 50 per arm. Within the 3 treatment groups, subjects were stratified according to their hormonal status (premenopausal vs. postmenopausal ) and Ductal Intraepithelial Neoplasia (DIN)/Lobular Intraepithelial Neoplasia (LIN)/Atypical Hyperplasia(AH) vs. High genetic risk and centre. A schema of the trial design is presented in Figure
Figure 1
Trial design
Trial design.
Participants selection
Eligible subjects are women at increased risk for hormone non-responsive BC: patients with previous surgery for ER negative Intra Epithelial Neoplasia (IEN), and unaffected subjects carrying a mutation of BRCA1 or with high probability of BRCA1/2 mutation. This represents a relatively heterogeneous group with various degrees of risk, but all characterized by a higher probability to develop a ER negative breast cancer rather than other cohorts of subjects. Their risk is often confirmed by a diagnosis of IEN at young age and/or by an early germ-line mutation assessment. Moreover, no current preventive treatments (especially endocrine) could be reasonably proposed to most of these subjects.
– Patients with ER negative DIN (within 12 months from radical surgery)
– Patients with AH (within 12 months from radical surgery)
– Patients with LIN (within 12 months from radical surgery)
– Unaffected carriers of BRCA1 mutation
– Unaffected subjects with high probability of BRCA1/2 gene mutation (≥ 10 % according to Berry Parmigiani and/or Couch model).
On the basis of a weekly multidisciplinary meeting the candidates are contacted by phone by trained personnel illustrating the possibility of taking part in a chemoprevention trial and scheduling an appointment for an outpatient visit at the European Institute of Oncology. In case of a previous diagnosis of IEN, randomization is performed within 12 months from surgery. Inclusion and exclusion criteria are summarized in Figure
Figure 2
Inclusion and exclusion criteria
Inclusion and exclusion criteria.
Recruitment and retention strategy
Pre-initiation phase
Subjects with a previous surgery of ER negative IEN, and unaffected subjects carrying a mutation of BRCA1 or with high probability of BRCA1/2 mutation that are potentially eligible for the trial are addressed to the oncologist and the geneticist respectively.
Active recruitment
After the evaluation by the oncologist of the multidisciplinary team, patients surgically treated for IEN receive a Hospital Discharge Report including an appointment to discuss the trial and, when possible, the alternative options. Unaffected subjects carrying a mutation of BRCA1 or with high probability of BRCA1/2 mutation on the basis of the geneticist evaluation are contacted by the staff of the Division of Cancer Prevention and Genetics for a first phone interview and the check of all inclusion criteria. The trial design is explained and willingness to participate is asked. Candidates accepting to participate or interested in the study are invited for a clinic visit at the European Institute of Oncology (EIO) or the Department of Oncology & Haematology of the University of Modena and Reggio Emilia for informed consent and baseline visit.
Retention phase (including adherence strategies)
Subjects are scheduled for periodic visits (every 3 months in the first year) during which a complete physical exam and lab tests are performed. A couple of weeks before the following scheduled appointment, participants are reminded about the visit, blood test and physical exam. Recruitment and retention effort are evaluated routinely by the site coordinator and the study staff.
Treatment groups
Patients who signed an informed consent and who met the eligibility criteria are randomly assigned to one of three groups for 12 months of treatment, as follows.
Group 1: nimesulide 100 mg/day, administered per os and on full stomach. A single oral dose of 100 mg of nimesulide suppresses COX-2 activity by 90% in both in vitro and ex vivo assays and, at a much lesser extent, COX-1 activity with a 20-fold selectivity for the former isoenzyme
On May 15, 2007 the Irish Medicines Board (IMB) decided to suspend nimesulide from the Irish market and refer it to the EU Committee for Human Medicinal Products (CHMP) for a review of its benefit/risk profile. The decision was due to the reporting of six cases of potentially related liver failures to the IMB by the National Liver Transplant Unit, St Vincent Hospital. These cases occurred in the period from 1999 to 2006. On September 21, 2007 the EMA released a press release on their review on the liver-related safety of nimesulide. The EMA concluded that the benefits of these medicines outweigh their risks, but that there was a need to limit the duration of use to ensure the risk of patients developing liver problems is kept to a minimum. Therefore the EMA has limited the use of systemic formulations of nimesulide to 15 days. According to the European Institute of Oncology Ethics Committee communication, released officially on October 10, 2007 which recommended the maintenance of the study according to the present design, we are now performing an even more careful monitoring of the study participants and we are carrying out a systematic check of the possible side effects, both in those who are receiving treatment and in those who have finished. We have modified the Inform consent and we have informed all the participants accordingly.
Group 2: simvastatin 20 mg/day. The most important adverse events associated with statins are asymptomatic increases in liver transaminases, and myopathy. Myopathy and its serious complication, rhabdomyolysis, are potential side effects of therapy with the available statins, but occur very rarely. The molecular and biochemical mechanisms of myopathy and rhabdomyolysis caused by statins are yet to be fully elucidated
Group 3: placebo. An identical appearing tablet containing placebo is taken daily by participants assigned to the placebo group.
Toxicity is evaluated at each visit using the NCI toxicity criteria (CTCAE version 3.0, published 12/12/03). Any use of systemic drugs is clearly documented (time, doses, routes, and indications) and strictly followed by the physician. All medications (prescription and over-the counter), vitamin and mineral supplements, and/or herbs taken by the participant are documented on the concomitant medication CRF and included: start and stop date, dose and route of administration, and indication for use. Medications taken for a procedure (e.g., biopsy) are included. Patients are discouraged from taking unspecified medications.
Adherence/compliance to treatment
Although drug concentration is not being measured in the blood, compliance is monitored in the following ways.
Patient self-report
Patient's history—the most direct source of information—is the most widely employed measure of a patient's adherence to their medical regimen. However, patient self-reporting has been criticized as being too subjective, with patients tending to over-report their adherence by as much as two to fourfold. Positive information is helpful, but false negatives are common.
Calendar completion
Each subject is given a 7-month calendar as a reminder of drug consumption. Each subject is asked to cross the corresponding day of the calendar (1 cross for each consumption). Subjects are asked to fill the calendar and some additional space is left for patient's notes. Each calendar is returned at the next scheduled visit.
Dose count
Each subject receives a 6-month supply (at baseline and 6th month visits) of the drug or placebo and they are asked to return all full and empty packs, irrespective of their use. Pills are counted and the compliance is measured as follows: number of pills taken (i.e., number of pills given-number of pills returned)/number of pills that should have been taken during that period of time. If packs are not returned, the compliance is calculated from the calendar. In case of discrepancy between the pill counts and the calendar, pill count is taken as the superseding compliance measure.
Clinical evaluation and procedures
Date of birth, occupation, complete address and phone number, full details of family doctor; previous medical history; general physical examination, including anthropometric features; first or second degree family history of cancer; number of pack-years of cigarettes; alcohol consumption; concomitant medications.
Participants are assessed at baseline, 3, 6, 9, 12 and 24 months with clinical examination and blood safety tests. Mammography are performed at baseline, 12 and 24 months. DL are performed at baseline, 12 and 24 months in all subjects. In case of anatomical impediments to perform DL, this is substituted by a breast fine needle aspiration (FNA), preferably ultrasound-guided in the most dense area of the breast. Breast ultrasound is performed in premenopausal women at baseline, 12 and 24 months, in postmenopausal only if indicated by the study physician. Blood drawing for biomarkers and hormone measurements are done at baseline, 12 and 24 months. Intervention with nimesulide or simvastatin or placebo continues for 12 months or until the occurrence of a serious adverse event, including breast cancer. A detailed follow-up schema is illustrated in Table
Methods for ductal lavage and fine needle aspiration
DL is performed by a single physician for both recruiting centers with a dedicated microcatheter (Sterylab, Rho, Italy) to cannulate ductal orifices on the nipple that are identified by nipple discharge. After the duct has been cannulated, and a small infusion of local anesthesia is performed, the milk duct is infused with a saline solution. DL is performed in the contralateral breast in DIN/LIN/AH patients and bilaterally in healthy high risk subjects or in DIN/LIN/AH patients when feasible. The fluid collected from the effluent tube is then analyzed for the presence of cell alterations. Ki-67 expression in epithelial cells obtained by DL is calculated using the percentage of cells expressing the antigen over the total number of epithelial cells. The localization of the cannulated duct is recorded on a specific nipple grid in order to collect samples always from the same breast duct (Figure
Figure 3
Ductal Lavage
Ductal Lavage. a | saline is injected through the catheter into the duct and the breast is massaged to bring ductal cells into the chamber of the catheter. An empty syringe attached to the catheter is used to collect the cells from the catheter chamber. Saline injection and massage are repeated until a sufficient sample has been collected. b | microcatheter. c | nipple grid. d | Examples of ductal epithelial cells collected by ductal lavage:
In case of anatomical impediments to perform DL, this is substituted by a breast FNA, preferably ultrasound-guided in the most dense area of the breast. In all samples obtained by FNA, ER, PgR, and Ki-67 are analyzed using the immunohistochemical (IHC) method. Ki-67 is expressed as the actual percentage of stained cells over a total of at least 2000 tumor cells at high magnification (400 x).
Methods for biomarker measurements
Fasting blood samples for circulating biomarkers are collected and stored at −80°C until assayed. All the circulating biomarkers are determined on serum. IGF-I and prolactin are measured by a chemiluminescent immunometric assay (Nichols Institute Diagnostics, San Juan, CA). The assays are performed on the automatic instrument LIAISON (DiaSorin Deutschland GmbH, Dietzenbach, Germany). IGFBP-1 is measured by a two-site immunoradiometric assay, IGFBP-2 by a double-antibody radioimmunoassay (RIA) and IGFBP-3 by enzyme-linked immunosorbent assay, all provided by Diagnostic Systems Laboratories Inc. (Webster, TX). IGF-I and IGFBP concentrations are expressed in nanomolar (nmol) concentrations to calculate the IGF-I/IGFBP ratio, which is used as a more sensitive index of growth factor bioavailability. SHBG and C-reactive protein are determined by a chemiluminescent immunometric assay provided by Diagnostic Products Corporation, Inc. (Los Angeles, CA) designed for the Immulite Automated analyzer. Estradiol is measured by a 3rd generation RIA provided by Diagnostic System Laboratories Inc. (Webster, TX). Estrone-sulphate and Dehydroepiandrosterone-sulphate are determined by RIA kits provided by Diagnostic System Laboratories Inc. (Webster, TX). Pre- and post-treatment blood samples obtained from each subject are assayed within the same run to improve analytical precision. All analyses are blinded to the treatment groups.
Toxicity and dose modification
Toxicity is evaluated at each visit using the NCI common terminology criteria for adverse events (CTCAE, version 3.0, revised June 10, 2003
Statistical consideration
Sample size
A total of 150 subjects are allocated in the three treatment groups: 50 for each treatment group. Within the 3 treatment groups, subjects are stratified according to their hormonal status (premenopausal vs. postmenopausal), DIN/LIN/AH vs. Genetic High Risk, and centre.
Such sample size yields a power of 80% to detect a reduction from an anticipated 50% 12-month prevalence of atypical hyperplasia and cellular proliferation (Ki-67) in the control arm to 25% in each of the treated arms. The specification of an alpha level of 0.1 and a one-sided test were used in the calculation of the power. Both choices of an alpha level greater than 0.05 and a one-sided test are justifiable in phase II studies, also considering that the study is interested in determining if the prevalence of atypical hyperplasia and cellular proliferation (Ki-67) is reduced by the investigated treatments. The planned sample size incorporates a correction for possibly inadequate tissue sampling in about 20% of study subjects.
Statistical methods
Each of the two active treatment groups will be compared separately with the control group for 12-month prevalence of atypical hyperplasia and cellular proliferation (Ki-67), considered as two distinct endpoints. The comparison will be based on Pearson's Chi-square test. A secondary analysis will be carried out within a Generalized Estimating Equations (GEE) logistic regression modeling approach. Such analysis will incorporate baseline and 12-month measurements, and will take into account possible correlation between the two assessments made within the same subject. Secondary endpoints considered in this study are represented by continuous variables. Treatment effect on their change over time will be investigated by means of covariance analysis (ANCOVA), possibly after suitable data transformations to achieve normal distributions.
A randomization list is prepared using permuted blocks to ensure that an equal number of subjects are assigned to the 3 arms at different points of the randomization process. Neither the investigators involved with the study nor the women participating know which type of preparation is administered. The treatment and pertinent arm to which a patient has been allocated is made known only in the case of proven need (e.g., severe adverse events) by the Data Center upon formal written authorization of the Principal Investigator.
All participants, those who administer the therapy and those who assess the outcomes are blinded to group assignment to ensure the double blind design. Both nimesulide and simvastatin have been purchased from the market, placebo capsules have been prepared by the Hospital Pharmacy of the European Institute of Oncology (EIO). All the treatments are blinded by over-encapsulation and appear as capsules (size 0) of the same colour and exactly identical. Drug or placebo are provided in boxes (of identical shape) containing the capsules needed for each semester. They are manufactured by the EIO pharmacy. The code will be revealed to researchers and participant once recruitment, data collection, and laboratory analyses are complete.
Recruitment and preliminary results
Among the 528 women evaluated for protocol inclusion, 388 were eligible according to inclusion criteria characteristics. The flow diagram of study of the randomized trial is shown in Figure
Figure 4
Number of subject for each phase of the randomized trial
Number of subject for each phase of the randomized trial.
The success of chemopreventive approach depends on the recognition of high-risk subjects, the development of novel and safe agents, and the identification of new surrogate endpoint biomarkers using molecular pathways and new targets of drugs activity. Several chemoprevention studies have demonstrated that it is possible to reduce the incidence of hormone receptor positive breast cancer and that chemoprevention is clinically safe and well tolerated. Unfortunately we have no effective agents to prevent ER-negative breast cancer which accounts for 20–30% of breast cancers and has a poor prognosis
Competing interests
The authors declare that they have no financial or non-financial competing interests.
Authors' contributions
BB, AGG and DR have made substantial contributions to conception and design. ML, AGG, SM and DR have been involved in drafting the manuscript, analysis and interpretation of data. ML, DS, MC, LC have recruited participants and they will performed the follow-up at outpatient clinic. CC shall carry out pathological analysis. CJ shall prepare the drugs and placebo. MC is the physician who will perform ductal lavage. MP is the radiologist who will read the mammograms and who will perform breast fine needle aspiration. Statistical analysis will be performed by DR. All authors have read and approved the final manuscript.
The trial is supported by the Lega Italiana per la Lotta contro i Tumori (LILT), Project number: 8/2007.We thank the data manager Isabella Marchi, Margherita Omesso for writing assistance and Giorgia Bollani for the artwork.
The trial is supported by the "Lega Italiana per la Lotta contro i Tumori" (LILT) - Project number: 8/2007.
Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008
Oestrogen receptor negativity as a marker for high-grade ductal carcinoma in situ of the breast
Biological markers that predict clinical recurrence in ductal carcinoma in situ of the breast
Prevalence of BRCA1 and BRCA2 mutations in triple negative breast cancer
Risk factors for breast cancer in women with proliferative breast disease
Breast cancer risk associated with proliferative breast disease and atypical hyperplasia
A prospective study of benign breast disease and the risk of breast cancer
Breast cancer incidence in women with abnormal cytology in nipple aspirates of breast fluid
Ductal lavage for detection of cellular atypia in women at high risk for breast cancer
Cyclooxygenase 2: a molecular target for cancer prevention and treatment
Induction of apoptosis and inhibition of cell growth in human hepatocellular carcinoma cells by COX-2 inhibitors
Cyclooxygenase-2 inhibitor induces apoptosis and enhances cytotoxicity of various anticancer agents in non-small cell lung cancer cell lines
Suppressive effects of nimesulide, a selective inhibitor of cyclooxygenase-2, on azoxymethane-induced colon carcinogenesis in mice
The selective cyclooxygenase-2 inhibitor nimesulide prevents Helicobacter pylori-associated gastric cancer development in a mouse model
Effect of a selective cyclooxygenase-2 inhibitor, nimesulide, on the growth of lung tumors and their expression of cyclooxygenase-2 and peroxisome proliferator- activated receptor-gamma
Cyclooxygenase-2 inhibitors demonstrate anti-proliferative effects in oesophageal cancer cells by prostaglandin E(2)-independent mechanisms
COX-2 inhibitors suppress lung cancer cell growth by inducing p21 via COX-2 independent signals
Statins personalized
Pleiotropic effects of statins
Pleiotropic effects of statin therapy: molecular mechanisms and clinical results
Statin prescriptions and breast cancer recurrence risk: a Danish nationwide prospective cohort study
Effects of nimesulide on constitutive and inducible prostanoid biosynthesis in human beings
Cyclooxygenase-1 and cyclooxygenase-2 selectivity of widely used nonsteroidal anti-inflammatory drugs
Safety of statins: focus on clinical pharmacokinetics and drug interactions
Statin-associated myopathy
Race, breast cancer subtypes, and survival in the Carolina Breast Cancer Study
Prevention of ER-negative breast cancer: where do we stand?
Pre-publication history
The pre-publication history for this paper can be accessed here:


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Zeolite/sintered metal fibers composites as effective structured catalysts
The catalytic filters of sintered metal fibers (SMF) coated by thin MFI-type zeolite (silicalite-1, ZSM-5) films have been synthesized and tested in the reactor with structured catalytic bed. The catalysts show multifunctional behavior, combining catalysis with heat exchange, mixing, and particulates removal. The reactors based on the zeolite/SMF composite elements have a three-level structure: (i) a micro-scale due to oriented submicron zeolite crystals; (ii) a meso-scale due to homogeneous porosity of metal fiber filters; (iii) a macro-scale due to the design characteristics of the catalyst packing. The catalytic bed of the FeZSM-5/SMFFecralloy was efficient and the one-step benzene hydroxylation to phenol with N2O at temperatures as low as 270 °C without loosing N2O via decomposition to nitrogen and oxygen (selectivity close to 100%). The catalyst was effective in the N2O decomposition at temperatures 400–500 °C.
- doi:10.1016/j.apcata.2004.11.012
- View record in Web of Science
Keywords: Metallic fibers Role: CAT (Catalyst use) ; USES (Uses) (iron alloy ; Bekipor ST 20AL3; zeolite/sintered metal fibers composites as effective structured catalysts); Zeolite ZSM-5 Role: CAT (Catalyst use) ; SPN (Synthetic preparation) ; PREP (Preparation) ; US ; silicalite ZSM5 zeolite catalyst hydroxylation benzene phenol manuf
[u'CAN 142:394102', u'45-4', u'Industrial Organic Chemicals, Leather, Fats, and Waxes', u'Laboratory of Chemical Reaction Engineering, LGRC-EPFL,Swiss Federal Institute of Technology,Lausanne,Switz.', u'Journal', u'0926-860X', u'written in English.', u'108-95-2P (Phenol) Role: IMF (Industrial manufacture), PREP (Preparation) (zeolite/sintered metal fibers composites as effective structured catalysts); 71-43-2 (Benzene); 78-10-4 (TEOS); 4499-86-9 (Tetrapropylammonium hydroxide) Role: RCT (Reactant), RACT (Reactant or reagent) (zeolite/sintered metal fibers composites as effective structured catalysts)']
Record created on 2006-04-18, modified on 2016-08-08


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Tag: horizon perfekt rumble
How Much Do You Like Your Camera? Rumble Winners Announcementwritten by mayeemayee on 2013-01-31 #news
It was a festival of appreciation for the Lomography premium cameras! Hey, why not? These are the gems that create Lomographic masterpieces after all!27 24 Share Tweet
How Much Do You Like Your Horizon Perfekt? Rumblewritten by mayeemayee on 2013-01-29 #news
The last Lomographic premium camera that will cap our rumble series is finally here to show you what it has got!1 9 Share Tweet


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On July 18th, 2016, the 4,000th article was added to the SuccuWiki!
The Angel Without Wings
For other uses of the word Succubus, see Succubus (disambiguation).
The Angel Without Wings is an novel written by Robbie Howerton. In this work various characters appear that are described as being Succubus in nature and action.
- Title: The Angel Without Wings
- Author: Robbie Howerton
- Published By: Trafford
- Length: 260 Pages
- Format: Hardcover, Paperback & eBook
- ASIN: B006WQFH1S (eBook)
- ISBN-10: 1426988273 (Hardcover)
- ISBN-13: 978-1426988271 (Hardcover)
- ISBN-10: 1426988265 (Paperback)
- ISBN-13: 978-1426988264 (Paperback)
- Publishing Date: December 5, 2011
- Title: The Angel Without Wings
- Author: Robbie Howerton
- Published By: Trafford Publishing
- Length: 260 pages
- Format: Hardcover and Paperback Formats
- Original Publishing Date: December 5, 2011
Plot Summary
The day that Robbie's baby sister was born, he meets a boy named Kevin. Years later, he meets him again. The two of them become great friends; however, Robbie can tell that Kevin has a deep secret. When Robbie's Papa dies, Kevin is forced to tell the truth about just who he is and why he is here. He had been sent back to earth after dying in order to kill demons, with the help of a weapon created by God himself, the God Sword, the only weapon able to kill a demon. After Robbie discovers this, he agrees to help Kevin with his task. Their group slowly grows, and then Robbie finds out another truth-the more Kevin kills the demons, the closer he himself gets to becoming the strongest demon in the world. Robbie has to protect him from this fate. However he puts the blame on everything upon the demons and swears to get his revenge on them all!
Book Review
At the time of this article's entry in the SuccuWiki, no review was available. Tera has this work on her reading list and will review it shortly.


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CMU Mucked Up Desert Challenge
North of Walker Field Airport
Sat 09/07/2013
400 Participants
Proceeds from the M.U.D. Challenge go to benefit Colorado Mesa University's Athletic Scholarship Fund, the Grand Junction Fire Department and those who have lost to Colorado Wild Fires. Participants will be able to test their survival skills against mother nature, and in the process, get a free T-Shirt and one free beer from Palisade Breweries Beer Garden for age eligible participants, with a reminder to drink responsibly. Also, Palisade Breweries Beer Garden, Live Music, Food and Vendors. Different obstacles include: Mud Hill (Drought conditions warrant), tire run, Hay bail climb, Mud crawl (drought conditions warrant), balance beam, a cognitive test, fire pit, rope swing, spiders web, ice dip, etc.
- Address:27 1/4 Rd H Rd.
Grand Junction, CO 81501


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Photo: David Soanes
Iveagh House
Saturday 15 October, 11.00am – 5.00pm
Iveagh House, now home to the Department of Foreign Affairs and Trade, was first designed in 1736 by Richard Castle and remodeled in the 19th century, when a Portland stone facade was added. Behind this facade is a large house dating from three distinct periods with a highly decorated sumptuous interior.
First-come basis: Just turn up and look out for Open House Dublin volunteers. Wheelchair Access. Please note that the 2.00pm tour will be given through Irish.
Designed by: Richard Castle / OPW Architects Department
Building Date: 1736
Location: 79–80 St Stephen's Green, Dublin 2


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1 March 2006,
London, South Kensington
Price realised GBP 3,600
Mary Fedden, R.A. (B. 1915)
Jocelyn's Dish
signed and dated 'Fedden 1991' (lower left), signed again and inscribed 'Mary Fedden/Jocelyn's Dish' (on a label attached to the backboard)
watercolour and bodycolour
8 x 11 in. (20.3 x 28 cm.)
New York +1 212 636 2000
London +44 (0)20 7839 9060
Hong Kong +852 2760 1766
Shanghai +86 21 6355 1766
Special Notice
No VAT will be charged on the hammer price, but VAT at 17.5% will be added to the buyer's premium, which is invoiced on a VAT inclusive basis.This lot is subject to storage and collection charges.
**For Furniture and Decorative Objects, storage charges commence 7 days from sale. Please contact department for further details.**
Saleroom Notice
Artist's resale right ("droit de suite") applies to this lot. Please see the Important Notice to Bidders posted in the salerooms and at bidder registration.
Design specialist Jeni Sandberg illuminates the origins of the lamp and advises on what to consider when buying
A look at highlights from the collection of the famed interior decorator, offered on 12-14 September at Christie's in Paris


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Number of Tables: 2
This IDC update tracks the vendors, technologies, and markets for semiconductors and technologies being sold into server, storage, networking, and security systems, which are the major components in the enterprise infrastructure and the datacenters of cloud service providers. This document provides an update on select semiconductor companies focused on delivering solutions for communications infrastructure in the cloud and IDC's estimate of the companies' quarterly revenue in the cloud and mobile communications infrastructure market for the past eight quarters up to the third calendar quarter of 2015, as well as key recent developments in the markets these companies serve. This update is part of IDC's Semiconductor Core Technologies: Cloud Infrastructure document series.
Enabling Technologies: Cloud and Enterprise Infrastructure
Intel Corporation, Cavium, Inc., Marvell Technology Group Ltd., Xilinx, Inc., NXP Semiconductors N.V., Broadcom Corporation, Microsoft Corporation
Cloud collaboration suites, Consumer device semiconductor, Ethernet switch, Wireless and wired communications semiconductor


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Latest figures from bank and credit card companies suggest UK plastic, card and online banking fraud losses ran to £209.3m
in the first 6 months of 2006.
1 in every 3 people has been a victim of card fraud with around £1.2m being stolen every day.
Although chip and pin has helped to bring down losses, card-not-present fraud where cards are used over the telephone, internet or for mail order, continues to rise.
If you had been a victim of fraud, we asked if your bank or building society was helpful in sorting out the problem and if you recieved a full refund.
You sent us your views, a selection of which are below. The debate is now closed.
I'm very careful about safeguarding my cards and banking details - although I do use internet banking. Despite this both my debit card and credit card (issued by the same bank) were fraudulently used at the same time - suggesting that someone inside the bank might be involved. The fraudulent transactions were picked up really quickly - by the company and myself - and I had no real problems in getting the money back.
What shocked me was the bank's dilatory attitude to following this up. The user bought a number of items - including air tickets - that should have made it easy to trace him/her. However, my impression was that no effort was made to trace the offender.Valerie, London
If banks and building societies want to shift responsibility to customers they should also take responsibility. Two cases show that neither they nor the police bother to follow up cases of fraud even when there are clues. In my case my cheque book was intercepted in the post. I never received it but as I don't often write cheques I didn't miss it. A large amount was drawn using one of the cheques. Fortunately I was overdrawn so the bank did not honour the cheque so there was no harm done and the cheque book was cancelled. I asked for a copy of the cheque and it showed the payee and where the cheque was presented, but neither the police nor the bank seemed to want to follow it up. There could be a thief at the post office or even within the bank system - but no one seemed interested in the details. In another case a friend of mine received an invoice from Dell for computers supposedly ordered by her using her card. It showed the delivery address somewhere in the Midlands. West Midlands police told her to contact her police (in Hampshire). They were not interested. What a wasted opportunity when details where available to follow up.Liz, London
Last week Alliance & Leicester phoned me about unusual activity on my debit card. There had been a couple of small amounts taken out by a company I had never heard of which they said were probably tests followed by the big one which was over £1000 to a company in Canada which I had also never heard of let alone had any dealings with. When I asked the bank how this could happen they said they could have just got the card number by random selection. I find this worrying as it means no matter how careful you are it can still happen! The bank blocked my card immediately and issued a new one which I should get in the next few days. They have also put my balance back to what it was before the fraud.Simon, High Wycombe
I am an artist and am the victim of a fraud regarding the sale of a painting.
The circumstance arose when I was emailed by a buyer, supposedly in Dubai, wanting to purchase a painting. He said he was also buying other works in the UK and wanted his associate in the UK to pay me by cheque for all his purchases, for me to keep my share and forward the balance on to his shipping agent, who would take care of the rest of the purchases and would pick up my painting.
I had some questions about the payment process but having had our questions answered I decided to go ahead with the deal. I had every intention of waiting for the cheque to clear before making the arranged payment using Western Union. Our bank, First Direct sent a text mini-statement by mobile phone, which showed our 'available funds' - with the cheque credited to our account, as did the statement on the internet banking system. I thus assumed the cheque had cleared and continued with the transaction. I would never have made a payment unless I believed this to be the case.
The cheque proved to be a forgery and I lost a great deal of money.
I suggest that showing a credit in an account that has not cleared is highly misleading. Other banks' internet services (the Co-operative Bank's 'Acumen' service for one) show both the cleared and uncleared amounts. If this had been the case with First Direct, I would have waited and would have realised the cheque was not good.
Having, in retrospect, discovered that this is a common form of fraud, it now seems very obvious that the fraudsters use this ambiguity to their advantage. A simple change to the design of a website and a little more detail on text statements could save innocent people from such scams.
First Direct has offered no financial support or help in this case and do not seem to value ten years of custom and investment with the bank.
Don, Hebden Bridge
My wallet was stolen recently. The thieves managed to steal £550 from a credit card in the wallet. The bank is refusing to re-pay the amount stolen as they say I must have been negligent in some way and given access to my pin number for the thieves to be able to access my account. I have assured them, categorically, that this was not the case. What help can I get?Tom, Ipswich
I had a cheque for £20,000 (made out to me by Halifax) stolen in the post and cashed at a Nationwide branch. It took the best part of a year for most of the money to be returned - it was £800 short. By the time I got most of it I was too exhausted by the whole thing to go and fight for the missing £800.
I was not paid interest on the money (which I presume the Nationwide had), and the financial ombudsman thought that given the full story this was fair enough.
I suffer from a chronic illness which makes it inadvisable for me to be under undue stress.
I found it humiliating being treated as if I was the criminal and not being allowed to talk to Nationwide myself - since they could not prove my identity. Everything had to go through Halifax HQ. I found the whole thing very, very lonely and would have valued some kind of support group.Jenny, London
A family member in London bought two drinks in a bar, paid for them around 12.43pm
(time on receipt) by credit card using pin and returned with card to her table. Unknown to her, her card had been stolen and just 6 minutes after a cash withdrawal was made from a nearby dispenser. The max. for one day was taken then just after midnight a further max. for one day was withdrawn from the same bank. She discovered her loss later (still in bar) and reported it to the police. Barclaycard told her at first that she would have to prove she had not given the number to someone but gave her forms to fill in. The outcome is not clear yet (no reply). I provide this information to warn others of the danger. She is now £900.00 overdrawn and has received no assurances that her money stolen presumably by someone looking over her shoulder to observe the pin and a pickpocket in the bar [will be returned].Anne, Stevenage
My 81 year old mother had her bag stolen with purse, cards and pin no. written on envelope from her sheltered accom. flat. The thief used it to withdraw 2 x 200 from her account with Lloyds TSB in Wigan. When visiting the bank on 2 occasions, they did not give us any advice re the situation, the police advised me saying 'it was theft from the bank'. I have complained to the bank, however they have refused to refund the money saying this is because the pin no. was with the card. I feel they have been as callous as the thief. What can I do? This is ongoing at the moment. Lorraine, Huddersfield
I purchased an item off ebay and I paid by direct transfer from my HSBC account. The next day I got an email from ebay not to pay, so I got onto my bank straight away to stop payment but they said they couldn't stop it going through, which was quite absurd. It takes 4 days to go into the other person's account and they couldn't stop it. Not only that, I did one wrong number on my security details and they stopped my account straight away. It's amazing how they can stop a person's account in 2 seconds but can't stop a payment that takes 4 days to clear. Now I've lost over £200.00 and my purchase has not arrived.John, Luton
I had my handbag (and filofax) stolen in central London last June. The difference between the various 'banks' attitude to the use the thieves put my various cards to was interesting. Capital One just refunded the card that was drawn within 1/2 hour of the theft - after telephoning me to check the position Lloyds refunded both the cash drawn on my card (again within 1/2 an hour) and the spending on the stolen cheques - partly their fault as [I was] told they 'overlooked' stopping the cheques. But they apologised profusely for their error.
Sainsbury's said 'tough you pay the lot'. They did not even bother to telephone me about the use of the card which was unusual as I had never, ever drawn cash on it before - although their fraud people parroted 'you were listed for a call' but could not even apologise that the call never took place! Phyl, Reading
I ordered about £500 worth of wines & spirits over the internet from an Italian firm. The goods were never sent despite many e-mails. I complained to my card company, Marbles, and it refunded my money in full without a quibble.Dave, Kendal
Nationwide contacted me by phone to advise me that they suspected that some transactions being put through on my Visa card may be fraudulent. They went through about 6 or 10 recent tranasactions and asked me to confirm which were genuine. Having estblished that there were 3 or 4 fraudulent transactions they immediately cancelled the card, removed the fraudulent transactions and issued me with a new card. About as painless as it could be.Derek, Beaumaris
Strange that the banks do not pay out when fraud occurs, as they certainly do not lose the money themselves.
As a small retailer I have been victim on numerous occasions to fraud and not once has the bank re-imbursed me. Richard, Brentwood
I was recently the victim of fraud after trying to order Christmas presents for my children over the net. I informed my bank who promptly cancelled my card after about £80 had been taken. 2 days later £1,600 was paid out for two lap tops. I was told this was due to these transactions having been invisible 'in the ether' at the time. I was pleased to have my losses reimbursed by the bank and grateful to them. Thanks to my husband's internet searches we actually were able to get the e-mail address of the culprit and passed this on to the bank, but no-one either at main office or at my branch could confirm whether or not this information would be passed on to the police. Though delighted to get my money back, I would hate to think that this person has got off scotfree. Do you know if card frauds are in fact pursued? Thank you.Elaine,Keswick
I had my HSBC debit card fraudulently used by having approximately £600 taken out of my account just before Christmas by two separate transactions in Malaysia. HSBC were very, very good, accepted that it was a fraud and replaced my money into my account within two weeks despite it including the Christmas period.
However, the two separate transactions caused me to go over my overdraft limit so really the second, cash, transaction should have not gone through. If I had used the cash machine opposite my house I am sure the machine would have eaten my card. Possibly then HSBC bank have been a bit negligent? Jacqui,Cambridge
I am a "Merchant" and in my experience of 20 years in finance dealing with all the clearing banks I have never found any bank being on the side of the victimised business. They take the easy way out of protecting themselves and the cardholder by carrying out charge back. They don't even advise businesses what to do when they do become a victim of fraud. Their response to the paperwork sent to justify the transaction is inadequate too. Most banks carry out the charge back within 4 days from receipt of notification and give you 14 days to send in the supporting paperwork, this too is unfair.Syrus, London
The comments we publish are not necessarily the views of the BBC but will reflect the balance of views we have received. It is helpful if contributors state if they work for any organisation relevant to an issue discussed. Readers should form their own views on whether messages published represent undeclared interests, or views prompted by a common source.
Download or subscribe to this programme's podcast
Most Popular Now | 56,514 people are reading stories on the site right now.";


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Find the Best Restore APK Mobile Android Apps and Games Below!
SMS Backup Restore - AD FREE Free
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App Backup & Restore – program to backup and restore apps for Android.
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Super Backup & Restore App. Easy APK Extractor, App Editor & Manager for Android
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Backup your messages, contacts, call logs, bookmarks and application.
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Dumpster works just like the recycle bin on your windows or mac desktop computer.
APP Backup And Restore 2 Free
take backup of selected or all the apps and allows user to share the apps
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A simple App to backup and restore APNs (Settings to connect to the internet with the mobile connect
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Tool box provide extra features for Where's My Water games(unlock levels, backup/restore, profiles)


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3rd Shift Production Supervisor
Dallas , Texas
November 03, 2016
The individual selected will be responsible for providing leadership to a shift of production operators on safety, quality, performance and trouble shooting, staffing issues, training, etc. Lead TE, cost reduction, and other improvement efforts on one or more production lines.
Key Responsibilities & Accountabilities:
Responsible for accident investigations for accidents and near misses on the shift
Lead and or participate in Safety Program elements
Meet AIB and food safety requirements for your areas as designated
Assign sanitation responsibilities for work areas and production lines as designated
Maintain accountability of employees' schedule, line coverage and correct work hours. Reconcile materials used and product produced on your lines in MARS and SAP
KPI tracking for safety, quality, cost and TE performance on your lines
Completion of assigned TPM/HPWS roles and activities
Facilitate line-troubleshooting activities for issues on your lines
Support new materials and product testing on the shift
Ensure SOPs are current and are being followed for activities on your lines
Work with the Maintenance team to track and prioritize maintenance work items on your lines. Management of first step grievances
Lead the shift meetings for your lines and ensure effective pass downs are conducted
Lead a loss reduction project
Bachelor's degree is required and a degree in supply chain, engineering or a similar function is strongly preferred
A minimum of 2-3 years of Operations or Logistics experience
Ability to work a flexible schedule including early mornings, evenings and/or weekends
Demonstrated planning and organization skills
Demonstrated front-line supervisory skills
Relocation Eligible
Not Eligible for Relocation
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Our nation's veterans bring unbeatable life experience, job skills and leadership to PepsiCo. Together We Win.
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At face value, the new PC-24 jet, launched by Pilatus in May, should be well suited to Latin America's needs and aviation infrastructure–not least because of its versatile operational performance which enables it to operate from short and unprepared runways (2,690-foot balanced field length at max takeoff weight). The Swiss company has spent a long time conferring with prospective customers and it believes it is on course to deliver the ideal follow-on product from its successful PC-12 turboprop single, when it achieves certification in early 2017.
"The PC-24 is unique," claimed Pilatus chairman Oscar Schwenk. "It's the only aircraft combining the versatility of a turboprop with the cabin size of a medium-size jet and the performance of a lightjet."
Intended for Part 23 certification, the PC-24 can be flown by one pilot. Two Williams International FJ44-4A engines help the PC-24 climb to its maximum altitude of 45,000 feet in under 30 minutes and achieve a high-speed cruise of 425 ktas at 30,000 feet. Range with an 800-pound payload (four passengers) at long-range cruise speed and NBAA 100-nm IFR reserves is 1,950 nm. Maximum takeoff weight is 17,650 pounds and maximum payload is 2,500pounds.
With seating for six to eight passengers or up to 10 in commuter configuration, the PC-24's cabin volume is 501 cu ft, "much more than bigger aircraft that cost twice as much," Schwenk said. The cabin has a flatfloor and features a large cargo door like the PC-12, plus a pressurized baggage compartment.
Key to the PC-24's short-field performance is a unique design feature of the jet's two 3,435-pound-thrust Williams engines. An additional 5 percent power is available via a new automatic thrust reserve feature, according to Williams International. The turbofans also employ Williams' Exact passive thrust vectoring nozzle technology, which uses the Coanda effect to provide a three-degree "vectored" thrust during high-power operations. The Exact feature was planned for Piper's cancelled Altaire single-engine jet, although using a higher seven-degreevector.
An anti-ice and noise-suppressing inlet is supplied by Williams, as is an integral pre-cooler "to condition engine bleed air and reduce drag losses." The PC-24 doesn't need an APU because the FJ44s use Williams's quiet power mode to provide ground power efficiently and with little noise. The engine has a 5,000-hour TBO and hot-section interval of 2,500hours.
The avionics suite consists of a Honeywell Primus Apex flight deck, which for this platform is branded as the Pilatus Advanced Cockpit Environment. The most basic version includes four 12-inch displays, Honeywell SmartView synthetic vision, Tcas II, inertial reference system, Waas LPV approaches and graphical flight planning on the movingmap.
The cockpit will also feature the integrated navigation data service (INDS) data manager for the Apple iPad. The INDS, developed by Jeppesen and Honeywell (Stand 1004), simplifies the Honeywell Apex database update process, allowing wireless updates through the iPad. An Aspen Avionics CG100P Connected Panel device is part of the INDS system; this is the first selection of Aspen's Connected Panel for a businessjet.
Pilatus has already begun building the prototype PC-24 in a small hangar tucked into the edges of the company's Stans, Switzerland headquarters. The first PC-24 is to roll out in the third quarter of 2014 and fly before the end of the year. European and U.S. certification is planned in early 2017, according to Schwenk, and first delivery will take place immediately aftercertification. The PC-24 will sell for $8.9 million in 2017 economic terms, according to Schwenk. Pilatus won't officially start taking orders for the new model until next May. Financing for the program is entirely from Pilatusfunds.
Proud of his company's efforts, Schwenk introduced the new PC-24 at the recent EBACE show in Switzerland as a "super versatile jet" or SVJ, because, he explained, it's in an entirely new category for businessjets.
Defying Categorization
To some extent, the PC-24 defies categorization since it is unclear whether it belongs in the light or midsize classes. The new aircraft's 17,650-pound mtow, nearly identical to that of the Embraer Phenom 300, places it firmly in the light jet category. However, its 501-cu-ft cabin volume suggests it is midsize, since it is well above the 325 cu ft of thePhenom.
In fact, the PC-24's cabin is larger than the best-selling midsize jet–the Cessna Citation XLS+–in almost every respect; it is wider (67 inches versus 66 inches), longer (23 feet versus 18.5 feet) and more voluminous (501 cu ft versus 461 cu ft). In this matchup, the PC-24 loses only in cabin height–61 inches versus the XLS+'s 68 inches. However, the PC-24 has a flat floor while the Citation has a drop-down floor, so seated passengers won't have any more headroom in the XLS+ compared with the PC-24.
Dubbed "Crystal Class," the Pilatus jet's interior evokes the qualities of Swiss crystals: beauty, uniqueness and versatility, according to the aircraft manufacturer. The six-passenger cabin mockup demonstrates the first two qualities, while its versatility comes from no fewer than seven interior options, including three executive versions (six, eight and six/eight-seat quick-change configurations); 10-passenger commuter layout; combination (forward club-seat cluster and aft cargo); cargo; and medevac. In the three executive versions, the externally serviced lavatory can be located in the fore or aft cabin, and there is a galley option aswell.
No matter what configuration is chosen, operators are sure to appreciate the jet's large 4.1- by 4.25-foot rear cargo door as well as the ability to remove seats quickly and move the aft partition to adjust the size of baggage compartment or cabin. With the partition in the forward position, the baggage compartment volume is 90 cu ft, large enough to hold a full-size motorcycle. In the aft position, the compartment encloses 51 cu ft. The cargo door height is 4 feet 3 inches and usable width 4 feet 1 inch, large enough to accommodate standard-size cargopallets.
Pilatus has not yet selected a cabin management system (CMS) for the PC-24, saying that technology advances in these electronics are occurring so rapidly that it is still too soon to commit to a CMS for a jet that won't be certified until 2017. But it has chosen Boulder, Colorado-based Air Comm to provide the PC-24's environmental cooling and heatingsystem.
Innovative Solutions & Support (IS&S) was chosen to supply the PC-24's utilities management system (UMS), which uses a multi-line Ethernet network to monitor and control PC-24 mechanical and electrical systems and the jet's avionics. The UMS consists of four identical IS&S data concentration and processing units, each with two channels but dissimilar hardware and software. The units control and monitor "navigation, autoflight, landing gear, surface positions, fire protection, ice/rain protection, electrical loads, lighting, environmental conditions, cabin pressurization and oxygen systems," according to IS&S, as part of the company's UMS-100 utility management system product family. Another UMS-100 feature is the ability to act as a central maintenance computer and transmit real-time fault reporting data via satcom or other datalinks.


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|Please note: This article is about the Memory Stick. For other uses of the term, please see A'op'chtch-tchr (disambiguation).
The Father's Stick was a Memory stick of the nezumi which told the tale of a brave father who rescued his kidnapped pup. The stick was attuned to a specific, willing creature. Any nezumi holding the stick to command it to point unerringly toward the creature to whom it was attuned. The Chipped Tooth Tribe used these sticks to find those that had been lost at sea. [1]
- ↑ Way of the Ratling, p. 85
|This magic or religion related article is a stub. That means that it has been started, but is incomplete. You can help by expanding this article.


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Sevilla - Alves not for sale
Sevilla insist they would only swap Daniel Alves for Lionel Messi if Barcelona paid an additional 30million euros.
By Lucas Brown
Last Updated: 08/02/08 12:46pm
Sevilla president Jose Maria del Nido insists the club would only swap Daniel Alves for Lionel Messi if Barcelona paid an additional 30million euros.
Alves was strongly linked with a move to Chelsea last season, while Real Madrid are also thought to be keen on the attacking full-back.
A number of clubs are understood to be ready to test Sevilla's resolve again this summer and Barcelona have been rumoured to be favourites to land the Brazilian.
However, Del Nido has labelled Alves the 'best player in Spain' and is adamant he would only agree to a hypothetical swap deal for Barcelona star Messi if the Catalan club paid an additional 30m euros (£22m).
When asked if he would swap Alves, Del Nido told reporters: "For absolutely nobody. For Messi and for £30million euros. Alves is the best player in the league now.
"We have to be careful and be open. But I guarantee you that if Sevilla do not want to sell, then we will not sell."


text:
by Harold Friend
The Cardinals had staged one of the greatest miracles by overtaking the Giants to become 1934 National League champions, but National League president John Heydler addressed some dark thoughts. About one month after the regular season ended, Mr. Heydler disclosed how he kept all the games played by the contenders under close surveillance in order to avoid any scandal.
Suspicions About Observing the Reds
Nothing would have been publicized, but Mr. Heydler realized that there were suspicions that the Cincinnati Reds' performances had been under great scrutiny. The last place Reds dropped their last four games of the season to the Cardinals while the sixth place Brooklyn Dodgers took two vital games from the Giants, resulting in the Cards winning the flag by two games.
Mr. Heydler denied that the Reds had been checked more closely than any other team. "There is no basis for any suggestion that we had cast suspicious eyes at the performance of the Reds. I had reports immediately after every game participated in not only by New York and St. Louis, but by the contestants for fourth place. I had my confidential representatives watching not only what took place on the playing field but off the field."
Specifics Were Provided
1. What was the character of baseball played against New York and St. Louis by otherwise hopelessly beaten clubs?
2. Did they present their best lineups and a fair rotation of their pitchers?
3. Did they put forth their best efforts?
4. Were any decisions made that could possibly lead to a protested game or that could be construed as discriminating against either contesting club?
The National League Didn't Want a Repeat of the 1924 Scandal
It was explained that the league didn't want a repeat of the Dolan-O'Connell scandal of 1924. After the Giants won their fourth consecutive pennant, there were accusations that some Giants' players had offered Philadelphia Phillies' shortstop Henie Sand a bribe of $500 to "lay down" during the final games between the two teams.
The players involved were young outfielder Jimmy O'Connell, who claimed that he was put up to the dastardly deed by first base coach Cozy Dolan. O'Connell also claimed that Frankie Frisch, Ross Youngs, and George Kelly knew about the scheme.
Commissioner Landis Holds a Secret Meeting
Frisch, Youngs, and Kelly denied any involvement and insisted that it was only a joke, but Commissioner Landis was never in a humorous mood. He held secret meetings, after which it was announced that young Giants' outfielder Jimmy O'Connell and first base coach Cozy Dolan were banned from baseball for life. Frisch, Youngs, and Kelly, were exonerated of any wrong doing.
No Guarantees
It is fascinating that players on a team clearly in command of the pennant race could be so insecure that they feel that need to bribe the opposition, but that merely once again confirms the similarities between life and baseball. There are no guarantees, and no lead is safe.
Mr. Heydler Had to Be Certain
Almost no one thought that the 1924 Giants would lose their final two games to the Phillies while second place Brooklyn would win two from Boston to tie for the pennant. but it was possible. It turned out that Boston beat Brooklyn, the Giants beat the Phillies without help from Henie Sand, and the Giants won the pennant, but Mr. Heydler, 10 years later, had to be certain that the Reds, Cardinals, Giants, and Dodgers played the game for all they were worth.
By The Associated Press.. (1934, November 1). HEYDLER UPHOLDS PLAYERS' INTEGRITY :Discloses Strict Surveillance of Critical Games in National League Pennant Race. ANSWER TO REDS' INQUIRY Circuit Head Denies Cincinnati Club Was Suspected While Losing Four to Cards.. New York Times (1857-Current file),27. Retrieved July 18, 2009, from ProQuest Historical Newspapers The New York Times (1851 - 2006). (Document ID: 94577136).


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Find a wide selection of Meadow Brook Amphitheatre event tickets to choose from on TicketNetwork, including Meadow Brook Amphitheatre concerts, and all other events. Whether you live nearby or are traveling, don't miss out on the upcoming events at Meadow Brook Amphitheatre. See the full schedule of shows at Meadow Brook Amphitheatre below, and find tickets by clicking the show you'd like to see!
|Date & Time
Sep 03, 2017
|Garrison Keillor
|Rochester, MI
Meadow Brook Amphitheatre
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Punctuate a birthday with a concert, make an anniversary extra special with a trip to the theater, or take the kids to watch a ball game. Whatever the occasion, TicketNetwork can help you find Meadow Brook Amphitheatre tickets!


text:
We can't possibly choose between this pleated skirt and these paisley-print pants, and you can't make us. We'll just wear them both at the same time, with the help of J. W. Anderson, who has helpfully joined the two together for us. And what J.W Anderson has put together, let no fashion police officer put asunder. Far be it for us to suggest that there's no need to spend £1,275 on this creation, when you could find an ugly pair of pants and an equally ugly skirt for a mere fraction of that price and wear them together. Nuh-uh. We know a bargain when we see one, and this has been reduced to $510, for reasons that we can't possibly even begin to guess at. Go get it, fashion jurors! Snap it up, before someone else does! Then go forth and wear your paisley-print two-piece with pride![Buy it here]
Fashion Police


text:
Dirac had discovered a relativistic wave equation for a spinless massive particle with only positive energies. It has a defect: it became inconsistent when electromagnetic interaction was included. In this paper this problem is surmounted simply.
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text: Craighall Riesling 2004 This is moderately rich in colour for a young dry Riesling. It has a fresh hue and a nose of talc, lime and lemon zest, pineapple (?) and a whiff of African violets. The palate is somewhat rounded and moderately structured. It has a clean entry, is dry and full length, and has an elegant finish and a persistent aftertaste. It has cleansing mineral flavours tasting of crushed lime, lemon curd and sherbet. My best guess is that it will show its best at 3 to 6-7 years, depending on the cellar. Review in about 2006/07. View cellaring information > Default Title - $0.00 NZD You must be a registered Dry River customer to purchase wine online. Register your interest. Previous Vintages Riesling Spring 2004


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I am very excited to have Melanie from My Friendly Reminders as a guest poster today! I met her in Denver and I love the concept of their site! Check this out!
The holiday season has arrived, which means it's finally time for hot cocoa, beautiful decorations, lots of shopping, and of course, holiday parties. I'd say it's a pretty safe bet that you're either hosting or attending at least one holiday-themed shindig this month. I'm also going to guess that if you have some dietary restrictions, these holiday parties may be a little stress-inducing.
We all know how important it is to share our dietary restrictions but up until now there really hasn't been an easy way to do so. That's where Friendly Reminders comes in, a site we created to make it easy to share dietary restrictions and food preferences with your friends, family or coworkers.
At Friendly Reminders, we want all hosts to cook confidently knowing their guests will be able to eat the food they've prepared and we want all dinner party guest to rest easy knowing that their host knows exactly what they can and can't eat.
How does it work? It's easy! Let's say you're hosting an event. Simply ask your guests to fill out a profile for themselves. Here's an example of one:
Once you're connected, you add them to your event and pull a report (it's super easy). The report will show you which allergies, intolerances and diets you need to be aware of for a select group. It also shows you the top food, drink and alcohol preferences within the group. It looks like this:
Cool, huh? I truly hope My Friendly Reminders will take some of the stress out of your holiday season.
Please visit MyFriendlyReminders.com
and let me know what you think.


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Moroni in Joseph Smith's Bedroom
Moroni in Joseph Smith's Bedroom
Post date:
February 19, 2016
Joseph Smith's official, canonical account of Moroni's first visitation to him includes specific details that pose some interesting and challenging difficulties for the veracity of the account. According to the account (written in 1838), Joseph was praying at night on September 21, 1823, when a light appeared in his bedroom and "continued to increase until the room was lighter than at noonday" (Joseph Smith—History 1:30). The angel then spoke to Joseph at length, reappearing two more times in the same manner, keeping Joseph awake most of the night (1:30-31).
What this account neglects to mention is that Joseph shared his bedroom, and even his bed, with some of his brothers. None of the adult children of Joseph Sr. and Lucy Smith had yet been married and all nine of them still lived with their parents. In September 1823 the Smith children and their ages were Alvin, 25; Hyrum, 23; Sophronia, 20; Joseph Jr., 17; Samuel, 15; William, 12; Katherine, 10; Don Carlos, 7; Lucy, 2.
In an article in the LDS magazine Ensign, Donald Enders described the Smith log cabin as "a one and one-half story structure with two rooms on the ground level and 'a garret above divided into two apartments.'" Enders noted that "the chamber above the two rooms probably served as sleeping quarters for most of the Smith children." A bedroom was added in July 1821 as the children became older, but even so, at the time of Moroni's first visitation the log house was "home to parents and nine children," with room for at most three beds to accommodate the seven boys.1 Thus, Joseph shared one small bedroom with at least four and probably five of his six brothers, and in fact must have shared a bed with one or two of them.
This fact renders the scene described by Joseph fifteen years later highly implausible, since he claims that the angel's presence made the room as bright as mid-day and that the two of them engaged in conversation three separate times throughout the night.2 Even LDS historian and Joseph Smith biographer Richard Bushman indirectly acknowledges the problem when he explains that Joseph's first vision (in 1820) took place in the woods because there was "no hope of privacy in the little cabin filled with children and household activity."3
Mormon apologists have offered various ad hoc responses to this problem. Ashurst-McGee's response is typical: "For those who do believe in Joseph's visions, the argument sounds theologically naive. Could not Moroni manifest himself to Joseph only? None of Paul's companions on the road to Damascus saw the resurrected Christ. A vision needs only to hold the attention of the visionary. Joseph's brothers can sleep in peace."4 The differences in the two cases are obvious:
- Luke mentions Paul's companions' presence, but Joseph did not mention his brothers' presence.
- However one interprets Paul's experience, Joseph's experience was supposedly not just a vision but a visitation; i.e., Moroni was supposedly literally, physically in the room. Here it is worth noting that Ashurst-McGee himself recognizes the significance of this distinction.5
- Paul's companions did not see Christ, but they saw the light, saw Saul fall to the ground, and afterwards helped him to get to Damascus because they knew he had been struck blind (Acts 9:4-8). Joseph's brothers and other family members apparently saw and heard nothing, despite the brilliant light and the long conversations that took up most or all of the night (JS-H 1:47). We know they did not see anything unusual that night because the next day Joseph's father knew nothing about what had happened until after Moroni appeared to Joseph a fourth time and instructed him to tell his father (1:49-50).
The problem of how Joseph's family could have been unaware of Joseph staying up all night talking to a brilliantly shining angel could be solved by taking the position that the experience was originally understood as a dream vision rather than a visitation. Such an explanation merely defends one element of the canonical account (the nocturnal experience in Joseph's bedroom) by rejecting another element of the same account (the literal appearance of a resurrected man in the room). It therefore fails to make the account any more plausible.
It might seem easy enough to dismiss the problem as a mere trifle, an instance of carping at a minor detail. However, the credibility of the account and of the one who gave it depends on the credibility of its specific elements. If it is not plausible that Joseph and a gloriously shining Moroni carried on lengthy conversations in his bedroom at night, that conclusion calls into question the alleged event itself and raises legitimate doubt about the trustworthiness of Joseph Smith.
1. Donald L. Enders, "The Joseph Smith, Sr., Family: Farmers of the Genesee," in Joseph Smith: The Prophet, the Man, ed. Susan Black Eastman and Charles D. Tate Jr., Religious Studies Center Monograph Series 17 (Provo, UT: Religious Studies Center, BYU, 1993), 213-25.
2. Cf. Clay L. Chandler, "Scrying for the Lord: Magic, Mysticism, and the Origins of the Book of Mormon," Dialogue 36, 4 (2003): 54 (43-78).
3. Richard Lyman Bushman, Joseph Smith: Rough Stone Rolling, with the assistance of Jed Woodworth (New York: Knopf, 2005), 39.
4. Mark Ashurst-McGee, "A Pathway to Prophethood: Joseph Smith Junior as Rodsman, Village Seer, and Judeo-Christian Prophet," M.A. thesis (Utah State University, 2000), 293.
5. Ibid., 10.


text:
by Giselle
(Sylmar, CA. )
Dear Lord- I pray that you please give my grandmother the strength to fight cancer. Help her become stronger everyday. I pray that you heal her and you allow us the opportunity to fix the problems that broke everyone apart.
Join in and write your own page! It's easy to do. How? Simply click here to return to Prayer for Cancer.
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text:
Wmn's T-Shirt INDIAN BIRDIE
Prices incl. VAT plus shipping costs
1 currently available
Order before 12:00, and we will ship the same day.
Prices incl. VAT plus shipping costs
Order before 12:00, and we will ship the same day.
As the warmth of summer returns, migrate Pally'Hi's Indian Birdie short sleeve T-shirt into your wardrobe. Its lightweight 150g/m2 Merino-Bamboo fabric is light and airy, breathable and wicks sweat from the body keeping you dry. Whether you're lounging at home or off on distant travels, Pally'Hi T-shirts always offer the perfect blend of functionality and style.
60% Wool (Merino) 40% Viscose (Bamboo), 17.5 Micron
Temperate Weight (150gr)


text:
Last Month at the Federal Circuit - March 2004
Judges: Linn (author), Lourie, and Gajarsa
In Sulzer Textile A.G. v. Picanol N.V., No. 02- 1410 (Fed. Cir. Feb. 17, 2004), the Federal Circuit granted a petition for panel rehearing and modified an earlier opinion ("Sulzer I") by vacating and remanding the district court's motion in limine ("MIL") in view of Festo for a determination of whether Sulzer Textile A.G. ("Sulzer") waived the DOE defense, and, if not, whether Sulzer is estopped from arguing the DOE. The Federal Circuit's Sulzer I opinion and the facts of the case were reported in the January 2004 issue of Last Month at the Federal Circuit. After the Sulzer I decision, Picanol N.V. ("Picanol") filed a petition for panel rehearing, arguing that the Federal Circuit's determination that Sulzer had not waived recourse to the DOE was incorrect based on the record before the district court. Upon reviewing the papers filed by both Sulzer and Picanol, the Federal Circuit discovered that the parties had failed to disclose certain facts, including material differences between the district court's nonfinal pretrial order and the final one. As a result, the Federal Circuit granted Picanol's petition and agreed to reexamine whether Sulzer's failure to argue infringement under the DOE was a waiver. Thus, in the instant opinion, the Federal Circuit modified Sulzer I solely with respect to the district court's decision on the MIL preventing Sulzer from arguing infringement under the DOE. Picanol argued that Sulzer failed to raise equivalents during its case-in-chief based on trial strategy rather than the district court's evidentiary order, and, therefore, waived its right to appeal under the DOE. As evidence, Picanol pointed out that the district court's MIL order did not issue until one day before the close of evidence. By comparison, Sulzer argued that it did not present evidence of infringement under the DOE because, prior to trial, the district court, in an off-the-record communication, informed Sulzer that it would be precluded from presenting evidence under the DOE. The Federal Circuit examined the docket sheet from the trial and discovered that the pretrial conference did not mention a ruling on Picanol's MIL. Further, in the Joint Final Pretrial Order, which was entered about a week before the close of evidence at trial, the MIL was listed as still pending, suggesting that the motion had not been decided prior to Sulzer's case-in-chief. However, the Joint Final Pretrial Order showed that, unlike the draft Pretrial Order, the DOE was not listed as contested, suggesting that the MIL had been decided, thereby barring Sulzer from presenting evidence. Faced with these conflicting facts, the Federal Circuit determined that only the district court had sufficient facts to determine whether a waiver had occurred and ordered the issue remanded. The Federal Circuit further instructed the district court to determine, in view of Festo, whether Sulzer could overcome the presumption of prosecution history estoppel.


text:
Android Intent is the message that is passed between components such as activities, content providers, broadcast receivers, services etc.It is generally used with startActivity() method to invoke activity, broadcast receivers etc.
The dictionary meaning of intent is intention or purpose. So, it can be described as the intention to do action.
Types of Android Intents
1) Implicit Intent
2) Explicit Intent


text:
|GP: Bicycle ring in Suwalki Region - Poland
Bicycle ring in Suwalki Region
Project details and results
The Project aimed at establishment of 220km of marked bike-roads, using local path, country roads, in some parts - normal roads linking the most valuable places of Suwalki region (Suwalszczyzna) - Wigry National park, Romincka Forest Landscape Park, Rospuda Valley, unique bridge in Stanczyki. Information billboards with maps in key places were installed. From non-GEF funds watch-tower in Stary Folwark on Wigry Lake will be constructed.
Emphasis on sustainable Livelihoods
Potential growth of services provided by eco-agro-farms as a result of more tourists attracted by Suwalki region and promotion campaign (folders, maps, brochures, media) of created 220km bike system.
Project results
220km system of bike roads was marked in blue (including 560 small plaques, 10 big information billboards with maps) linking Wigry National park, Romincka Forest landscape Park, Sudawskie Mountains, Rospoda River Valley, Sejny, Punsk (capital of Lithuanian minority in Poland), Wizajny, Stanczyki and Suwalki and is passing through: Stary Folwark (Wigry National Park), Rosochaty Rog, Mikolajewo, Mackowa Ruda, Wysoki Most, Pogorzelec, Bialogory, Sejny, Zegary, Radziuce, Burbiszki, Buda ZawidugieskaPrzystawance, Trakiszki, Punsk, Wojciuliszki, Jegliniec, Podwojponie, Budzisko, Majdan, Kupowo-Folwark, Trzcianka, Folusz, Rutka-Tartak, Potopy, Ejszeryszki, Wizajny, Wizgory, Leszkieme, Mauda, Pobledzie, Degucie, Golubie, Maciejowieta, Stanczyki, Przerosl, Rahkowek, Czarne, Supienie, Wolka, Filipow, Szafranki, Garbas, Matlak, Bakalarzewo, Kotowina, Kamionka Stara, Wolka Folwark, Rabalina, Raczki, Dowspuda, Chodorki, Kurianki, Stoki, Franciszkowo, Jozefowo, Dubowo II, Suwalki.
This Project is part of the GEF Small Grants Programme (SGP) implemented in collaboration with UNDP
SGP Poland


text:
Sold Out $ 5.49
Whether it's the Wild West or the Present Day, somebody's got to enforce the law! This child-sized black sheriff's hat has a silver star "Deputy Sheriff" emblem and a cord.
100% polyester.
Type: hat
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text:
Upholstered Seat Bench - Canadel
If you would like more information on this item, please click the Request Information button above or call us at:
Tigard / Portland area: 503.620.6600
Eugene area: 541.636.4713
Category: Dining Room
Product Code: BEN08905ZC14MNN. Body Color: 14 - Sienna Washed*. Seating Color: ZC. Available Finishes: Matte M, Glossy G, Antique A.
Warranty Information
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Prices subject to home office audit & correction.


text:
Restylane Silk, a brand-new dermal filler from the makers of Restylane has all the benefits of regular Restylane, with the added bonus of 0.3% lidocaine. The addition of lidocaine, a local anesthetic, means the virtual elimination of discomfort or pain when having a Restylane Silk procedure done.
As with Restylane, hyaluronic acid is the main ingredient in Restylane Silk. Hyaluronic acid occurs naturally in body, and is essential for smooth and elastic skin. When we are young, our skin has an abundance of hyaluronic acid, but we lose it as we age. Restylane Silk can help restore your skin's youthful appearance.
Restylane Silk is a dermal filler that can be used to restore volume and fullness to the lips, as well as to fill in wrinkles and fine lines. After a Restylane Silk procedure, you'll appear refreshed and rejuvenated, with restored volume and smoothness.
What is the difference between Restylane and Restylane Silk?
Restylane Silk puts comfort first with the addition of 0.3% lidocaine, a local anesthetic. This addition to the formula trusted by millions means that any pain or discomfort typically felt during the treatment is significantly diminished.


text:
IT consulting - Laptop/Desktop
I will help you evaluate based on the needs you describe a solution either desktop, latop, used or new... and supply you with a link and recommendation on where to purchase that solution.
often enough we settle for whats just available on the show room at bestbuy without looking deeply to see whats available in the echo chamber that is ebay, and craigslist. Used pcs/macs not only save us on the bottom line but also help us to keep items out of the landfill.
Training & Qualifications
I am an IT guy with over 20 years experience working in all facets of tech from retail repair/support to corporate IT manager. each area has it's own needs and challenges and I can bring that experience to help you find what you need, and perhaps more of what you might want in the end.
Availability & Preferences
I'm usually free on the weekends, and evenings but I'm flexible.
Reviews of Doug
Mike received unit of IT consulting - Laptop/Desktop from DougSep 25, 2016
Preston received unit of IT consulting - Laptop/Desktop from DougAug 28, 2016
Rob received Help with Listen to and review my podcast from DougFeb 16, 2017
Christopher provided Help with iTunes Podcast reviews for DougFeb 09, 2017
Sarah provided package of Graphic Design (Logos, Flyers, etc) for DougNov 02, 2016
Sarah provided package of Graphic Design (Logos, Flyers, etc) for DougOct 10, 2016
Sarah provided package of Graphic Design (Logos, Flyers, etc) for DougOct 02, 2016
Melissa sold Kawaii Lantern Festival to DougSep 28, 2016
Jacob provided unit of Bad Jokes for DougSep 21, 2016
Alira A provided visit of Learn a Dragon Fact for DougSep 19, 2016
About Doug c
IT Gunslinger/Sysadmin for Hire; not a Hacker, or Cracker, New Father, Lucky Husband to an Amazing Wife, ENTJ, Linux Cowboy, Windows Veteran, Mac Magician; Websmith, BeardOilAlchemist, Ferromancer, 2n...dAmendmentLover, Want to know more just ask.show moreOpen to other proposals
Doug c is looking for:
- Writing & Editing
- Gardening
- Personal Training
- Yoga
- Fitness
- Custom Art
- Interior Design
- Website Consulting
- Web/Software Development
- Video & AV
- Classes & Webcasts
- Dietary Counselling


text:
The world's most expensive dog collar
Who in their right mind would buy this?
This dog collar, called Amour, Amour (French for "love") costs a whopping $1,800,000.00 – almost two million dollars.
It's a one-of-a-kind, 52-carat collar, with over 1500 hand-set diamonds and a crocodile leather band.
Hmm…wonder who's dog will be the lucky recipient?
Source: I Love Dog Diamonds


text:
As the title states.
heat: http://heatware.com/eval.php?id=64135
Like vulcan said. Use Grub to point to peppermint or vice-versa.
pm sent
Can a mod change the title to FS/FT please.
New processors that were only tested to make sure they work. They have not been overclocked at all. Bare processors only. I will...
Looking to purchase ASAP. Only thing is that I need it to be shipped out Monday 100%.
heat: http://heatware.com/eval.php?id=64135
Gtx 285, 2tb, 1tb, i7 870
I'm also looking for hard drives. 1TB and up, i7 870 processors and GTX 260s
Fedora and CentOS.
PM sent.
I'm about to keep it after this week is done. LMK either way.
Just found out my brother is gay, bump!
price drop
Pm replied. Shevanel, you don't mess around!
Need to move to something cheaper.
Evga X58 E758 TR
Looking to sell or trade my EVGA E758 TR. Comes in original box w/ all the accessories.
$190 shipped. Shoot me some offers....
Yup, it's a card that handles the power of studio plugins. Compressors,eq's,reverbs, etc... Dare I say it sounds close to hardware (outboard gear).
This might be a long shot in a computer forum but here we go. This is the pci-e version and comes w/ 4 great DSP powered plugins. I use them on...
Opty 165 and 7600gt w/ zalman vf-900. If interested, pm me.
I really like it. It's nice to see something different.
Yes you can use it.
very classic design
Separate names with a comma.


text:
My name is Jacqueline Hunter, and I am the Show Director for Craftadian. As an entrepreneur I am passionate about sharing my knowledge. I am always looking for ways to learn everything there is on Etsy, Instagram, Facebook and Twitter. My niche is helping handmade/creative entrepreneurs succeed.
I showcase, promote and support other artisans, artists and designers - and one of the ways I do this is through knowledge sharing.