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A/n: Okay, I finally got this idea I've been having up! Thanks a ton to my beta ConverseG1rl for giving me some pointers! You should go check her out after this. She writes some good stuff! :D And thanks to my sister too for explaining law to me when I bombarded her with questions. XD
Rating/Genre: T, but possibly M in the future. Romance/Drama/Humor
Disclaimer: I don't own Kingdom Hearts or else my favorite characters wouldn't always die.
90 Days
Chapter 1:
What just happened?
It was early morning when he plopped down on the living room couch while his younger twin still snored from the room upstairs. He took the remote from the armchair and flicked on the television as the screen transitioned from black, to a middle aged man standing in a suit, pointing a finger to a chart. "And today will be a high chance of rain showers from the early morning until late afternoon. If you are planning on going out, make sure to bring an umbrella."
"Well, duh," Roxas murmured, abandoning the TV as he made his way to the kitchen. He opened the refrigerator door and stared blankly at the emptiness inside. "…I guess it's the usual for breakfast," he shut it close with a sigh and heard the click from a door opening upstairs.
Ventus trudged down the steps slowly, swaying back and forth while Roxas suppressed the laugh that threatened to escape his lips as he looked up at his brother from below. "You gonna be alright?"
"…Nn," the blonde slurred, almost tripping over his own feet as he skipped the last step. "You didn't see that."
Roxas chuckled and stepped back into the room. "You want some toast?" He slid the toaster towards him on the counter and plugged it into the outlet.
"…We eat that almost everyday," Ventus spoke tiredly, whether due to it being early morning or of the idea of having more toast. "Don't we have anything else?"
"When you can afford 'anything else' yeah, we'll have something else."
Ventus frowned at the fact and immediately felt regretful for starting the topic. What was he thinking? They were college students. They couldn't afford to be picky when it came to anything that involved money. He was beginning to think that putting school before work was not so good of an idea after all... "Eh, never mind. Toast is fine, Roxas."
The blonde nodded and put some bread in the toaster. "You're not even dressed," he added, glancing the teen over in his pajama-like attire. A white shirt with a large green star on both sleeves and baggy grey sweats.
Ventus looked down at himself. "Oh, right," he gave a short shrug as his explanation. "I'll go do that now. We gotta go soon, right?"
"Yeah, in like a couple minutes."
"And you weren't going to wake me up?"
"Uh-uh. Last time I did, you got all pissy and told me to 'go away. I'm tired," Roxas mimicked his brother's voice, but ended up sounding like a PMSing girl.
"I don't sound like that," Ventus muttered embarrassingly and turned back up the stairs. He went into the bedroom they shared and opened their closet door. He pulled on some jeans over his blue boxers and switched his green night shirt for a T-shirt of similar color. Exiting the room, he went in the bathroom to brush his teeth and what-not and shortly after, met his brother back downstairs.
"Here," Roxas held out the small breakfast to him and Ven took it, biting down on it with a crunch. He opened his mouth to protest, but refrained from communication of the matter anymore. He was tired of the hardened bread all the time, but he didn't have much room to complain. Roxas balanced a job and attending college while Ventus thought it would be better to finish school quicker so he could work full time later. The idea didn't seem too bad when he was still thinking it over while sustaining a summer job before the semester started. Roxas even encouraged it at one point in time, but now Ventus could see his masked irritation and he had to admit, he was a little disappointed on how it was turning out too.
"I want my job back," the words fell from his mouth before he even realized what he said.
"Huh?" Roxas looked over his shoulder after unlocking the front door. "What did you say, Ven?"
Ventus just shook his head in response and turned the TV off, unplugging the outlet to save power before walking over beside him. "Did they say anything about rain today?" He leaned down to pull his shoes on at the doorway.
"Oh, yeah. You'll need your own umbrella though. Your class does end later than mine, right?" Roxas took the black umbrella rested by the wall in his hands.
"Mm-hm," Ven stood up straight and took the large navy one leaning against it along with his school bag sitting on the floor, "but only because my professor rambles on and on and on."
"You should just leave early then," Roxas turned off the living room light and grabbed his bag from the floor as well before walking out the apartment.
"Nah," Ven followed behind him, locking the door, "I don't want to miss anything important."
What just happened?
They followed the sidewalk, leading to Twilight University, up to the point to where they had to cross the street to go any further. The blonde pulled his brother back by the shoulder when he was about to step out onto the road just before a speeding car flew by. "Watch where you're going!" Roxas called, giving a roll of his eyes. "And what happened to looking both ways before crossing the street, Ven?"
"I know," he spoke softly after lifting his head up in surprise. He would have been if his mind wasn't calculating how he was going to get his job back. They were growing harder and harder to get now that the economy was going down. Why did I quit? he whined in his head before he sighed heavily.
"What's the matter?" Roxas questioned, lightening up on him.
"…Well, it's just-"
"Oh," Roxas nudged his shoulder, looking out onto the street, "Roads clear now. Let's go." The twin absentmindedly reached for the other's hand.
"You don't have to 'hold my hand across the street," Ventus said, despite allowing the gesture.
Roxas turned to look at him, blinking at first as if he wasn't aware of what he was doing before he stated, "After you almost walked out, I figure I should stay on the safe side." He let go once they had passed the crossing. Roxas was only four minutes older than him, but sometimes Ventus thought he acted like he was four years. Although they both had their share of acting older than the other, Ventus usually gave his twin the job of big bro since he played the role so well anyways. "Oh, what were you going to say before?" Roxas questioned, walking towards the visual arts entrance of the building.
Ventus figured his brother should be able to concentrate on his work in class instead of how stressed he was feeling at the moment. "I can't even remember," he lied and smiled goofily.
"Wow," Roxas couldn't help but smile back as he laughed. "Well, I'll see ya when you get home, Ven."
"M'kay. Later, Roxas!" He gave him a short wave as he turned down the opposite hall while Ventus went towards his class around the corner. He raised an eyebrow as he moved closer, noticing the closed door and lifted a hand up to rattle the silver handle. It was locked? His cheeks smeared against the glass window as he pressed his face against it to look around the dark, empty space. "…Well…I thought my class was today," Ven murmured against the pane before leaning back. He pondered whether he should just go back home then. Roxas did say it was supposed to rain and although Ventus wasn't sure when that was going to be, he knew he didn't want to get caught in it.
Deciding, he turned on the heel of his foot and soon exited from the doors he came from. He walked pass the parking lot and stopped before stepping out into the street this time. "Don't run out into the road while cars are crossing! I don't want what happened to mom to happen to you." Roxas's childhood advice suddenly echoed in his head and a bitter nostalgic smile crept on Ven's face. He waited for cars to drive by and began to tap his foot. Glancing up, he noticed the clouds were beginning to darken and huddle together. "Aw, come on," he frowned at the sky, "Hurry up." His attention shifted back to the road and he gasped at what he saw.
A small cat had leaped out onto the street. "…N-No, it'll-" Ven spoke almost faintly as he eyed it and he found his body reacting before his mind had the chance to. "MOVE!" he lunged forward and grabbed the animal when a loud screech tore through his ears, quickly followed by a resounding crash. For a split second, while his ears were ringing, he thought the crash was from the car colliding with his body and the damage was so immense he couldn't even initially feel it. He hoped someone would tell Roxas he was sorry that he got himself killed the same way their mother did.
Ventus slowly lifted up his head from his knees and he blinked his eyes open. The trembling cat jumped from his arms and out of harm's way as Ventus's embrace loosened around it. He sat up, feeling the sting on his left arm from where it scrapped against the cement, but he didn't pay it much attention as he was staring at the motorcycle embedded into a large tree. His jaw dropped open slightly and he briskly gathered himself to run over, avoiding anymore vehicles, to see that the ride was in even worse shape up close.
"…Oh, god…" Ventus breathed before noticing a vital thing to the accident was missing. "Who-" he cut his sentence short, hearing a low groan. Turning around, he saw a person steadily sitting up from the curb and rubbing his forearm. "…A-Are you okay?" Ventus jogged over to him worryingly as guilt tied knots in his chest.
Not answering, the biker grunted lifting the cracked helmet from over his head and gave his tousled hair a small shake.
Eyes, widening slowly, Ven stopped and stared at the teen before him. He'd never seen anything like it.
Dark hair spiked out in different directions, only described as a deep, rich kind of black like the bleakest point in the night sky while his eyes held a sunnier affect, radiating a golden hue under thick lashes. His skin was somewhat paler than Ventus's, but brought out his bolder features and drew attention to the tight black material he wore, defining every curve of muscle tone he had visible. He looked like a masterpiece. Ven figured some guys had all the luck because as far as the cerulean eyes could see he was…perfect.
"You fucking idiot."
Blonde brows rose at the annoyed tone that broke him from his admiring trance. He watched as the seemingly irritated teen stood to his feet to kneel beside his damaged bike. A black gloved hand brushed the bent handle bar before he stood erect and whipped his head around, "You're going to pay for that."
Ventus's eyebrows knitted together in a perplexed expression and he took a step back in defense. Was he trying to pick a fight now? He opened his mouth to object, but flinched when the boy stepped towards him and extended his arm with his palm out. "So how much money do you have?"
Ventus glanced down at his outstretched hand and exhaled silently in relief to the misunderstanding before he focused back on the situation at hand. What did he just ask him?
"Can you speak?" The teen tilted his head upwards to look down upon Ventus as if he was mentally ill.
Ven blinked once in surprise to the question before a scowl replaced his features, "Y-Yes, I can speak!" he balled his fists. The boy must have not heard him when he asked if he was okay. Ventus then relaxed his grip, hanging his head slightly in shame, "I…don't have any…" It sounded even more pitiful being spoken aloud. Why was he even telling a complete stranger this? As if it wasn't embarrassing enough. A college student with no money? How sad.
"None?" A dark brow raised in disbelief and a mocking pity. "Well, I'll tell ya what you're going to do. You're going to get some."
"Says who?" Ven quickly lifted his head up, glowering a bit. Where did some stranger get at telling him what to do?
"You see my lips moving? Says me," the raven haired retorted sternly and pointed a thumb over his shoulder, "And says the demolished ride back there."
Ven's eyes glanced over for a moment and he shook his head. "Listen, I am sorry about your bike, but that wasn't my fault. I had to save that cat."
The other boy looked as if Ventus just slapped him in the face or something. Wasn't his fault? Seriously? "You're right. I should've just run you over. What was I thinking moving outta the way? My bad." His voice held heavy sarcasm and the two were soon glaring at one another.
What a jerk, Ventus was beginning to think. What happened to that perfect being he just saw? "Well, I gotta go," Ventus turned around and adjusted his bag over his shoulder. "Glad you were okay," he added dryly before a hand clamped down on his wrist.
"Where do you think you're going?"
Ventus looked back in surprise. "To my house."
"Not without paying me back," the teen declared.
"I didn't do anything," Ventus took a couple of jerks to free his arm.
"Didn't do anything?" The raven looked at him like he was the pinnacle of stupid. "My motorcycle wouldn't be in a tree right now if you hadn't jumped your ass in the way to save what? A damn cat?" The blonde's valor nearly disgusted him. "And now look where that's gotten us."
"It's gotten you a crashed bike and me a sense of dignity. I did it because it was the right thing to do. If there's a chance for me to make a difference whether something lives or not I can't just not do anything…" Ventus's eyes were half-lidded as he stared down at the ground, yet he told the words undoubtedly. The raven made a sickened face.
"Oh, please. Spare me the hero speech. The right thing?" he repeated. "If I hadn't rolled off at the last minute, I would've died; sharing the same fate as my motorcycle over there. And you're going to stand there and tell me it was the right thing?"
Ventus gulped a little. He didn't have much room to argue, but he had been faced with the opportunity to save a life from a possible cruel fate. Perhaps the cat could've made it across the street on its own. Maybe. But how would Ventus have felt if that animal had flew into the air, already dead once the car hit contact, and he just stood around to watch? He couldn't let that happen, he wouldn't and he didn't. "…I'm sorry. I didn't think about the harm I could've caused to somebody else. My body just…moved," he retaliated and the raven clicked his tongue in response.
"You're an idiot. And I'm getting what you owe me whether you like it or not."
"How do you figure that? I already told you I don't have any money."
"You do go to college don't you?" He jerked his head towards the direction of the school building on the other side of the road.
"Yeah, and it's paid through student loans…"
"And a place you stay at? Are mommy and daddy paying for you?"
"No…" Ventus scowled at his taunting. He paused for a moment before he continued, "I live with my brother in an apartment. We pay for it. Well…kind of…"
"…So you're flat out broke?" he came to the final conclusion while Ventus nodded solemnly and the raven just shrugged. "Sucks for you. Shouldn't have jumped out into the street and maybe you could keep a couple thousand."
"A couple thousand? I don't have that! What are you-"
"But I bet your place is worth more than that." Ventus gawked for a moment before his eyes widened. A smirk spread across the other's face, "Are you thinking what I'm thinking? I'd say that's fair, right? You made me crash my bike; I make the government force you to give my moneys worth one way or another. Sounds good to me."
"N-No! You can't!" Panic rose in Ven's chest. "Roxas and I worked hard to get that place together!"
"Roxas?" he lifted an eyebrow. Now why did that name sound familiar? Where did he hear that? Back in high school…senior year, was it? The teen contemplated, recollecting his thoughts, "Then you're…Len? No… Ventus, was it?"
The blonde shifted slightly at the way his name rolled off the raven's tongue. He never knew his name could sound quite like that before. With his tone less livid and more confident if anything, he could bluntly hear the smooth velvetiness of the teen's voice. Ventus shook his head, praying a blush hadn't already dusted his face. "H-How do you know Roxas?"
"You didn't answer my question. Is that your name?"
"Yeah," Ven admitted, "but most people call me Ven."
"Well, I'm not most people, Ventus, so spare me the nicknames. Your brother was in one of my classes senior year."
"…Really?" He went to their high school? Ventus never saw him before; at least he didn't think he did. No, he would've remembered somebody like him, but Roxas never spoke of him. Though assuming how the guy's personality was turning out to be, he could see why.
"I just said that. And now that I got your name; Ventus Strife, nothing is really stopping me from suing you."
"You don't understand, I need all the money I can get! I can't afford to be sued. W-We'll lose our apartment!"
"Probably," he said with no remorse, "And it'll be all your fault. Too bad you picked an animal over the consequences." He picked up his helmet and held it under his left arm, "Maybe you'll think twice next time."
"No, please!" Ventus grabbed his wrist before he left and the teen looked back leisurely over his shoulder. "You can't do this. Roxas, he'll… He'll be so angry. He works hard enough to keep a roof over our head. I can't just let that all go to waste. It'll…" It'll be all my fault. Ventus stared down at the ground. What would Roxas say if they lost their house because of him? What would he think? He would look at him in so much shame, so much disgrace. He would hate him and Ventus would hate himself for that. "Please, I'll get a job," his voice came out somber. "I'll pay you back."
He sneered, "And who knows how long that'll take, seeing as you don't even have one now. If you did, I wouldn't have to sue you to get the money. All the things you could've done to avoid this situation and you go through every wrong door." He shook his head as if he was looking at some naïve child.
Ventus's hands fisted by his sides, "I'll try to find a job as soon as possible."
"…Nah, that's not good enough."
"Come on! All I'm asking is that you don't sue! Please, I-"
"Fine. Stop groveling. It's pathetic." Ventus clamped his mouth shut into a frown. "Since you're so desperate, I suppose I'll let it slide."
The blonde blinked in surprise and then a grin of relief spread over his face. "Thank-"
"But," the sinister teen raised a finger, "You have to do something for me."
Ventus's eyes narrowed as he made an uncertain expression. "…Like what?" he inquired reluctantly. He didn't have much to offer. He lacked money. He didn't own anything of high value. He didn't have some secret knowledge to share. The only thing he really had that he considered important was Roxas. So what in the world could somebody like him do for a guy like this?
"I'm thinking along the lines of servitude."
"…Say what now?"
He continued, relishing in the jaw dropping look on Ventus's face. "My bitch, my slave, subordinate, lackey, whatever you wanna call it. Bottom line is, you do whatever I say when I say it. No objections and no complaining."
"…Are you crazy? I'm no one's bitch!" Ventus could hardly believe what he was hearing! "Especially to some guy I don't even know! Forget that!"
"Okay. See you in court."
The blonde grimaced as he was about to storm off, offended and angry. He couldn't. He just couldn't agree to such terms. His servant? It was ridiculous. He'd be the biggest idiot on Earth if he ever agreed to something as demeaning as that. But…if he didn't they'd lose their house! And he just couldn't explain to Roxas why their home was being taken away. That is, if Roxas isn't heated enough to actually listen to his explanation. No, it was selfish. Maybe if it was just Ven's place, he could, but not when his brother was in danger too. He would just have to settle for blackmail.
"I said fine," he grudgingly spat out, arms crossed in an immature fashion.
"We've already established that I'll see you in court."
"You know what I mean," Ventus could've sworn he just wanted to hear him say it. "I'll…be your assistant or whatever."
"…Suit yourself." Ventus heard the mono tone, but caught the victorious smirk on the other's face before rain started to lightly drip from the sky. The teen glanced up at the water droplets hitting his face and then at Ventus. "Is that an umbrella?"
"Hm?" Ventus moved it from behind his back. "Yeah."
"You can start earlier than I thought then. Give me it."
"What? No!" Ventus gripped it towards his chest. "I need this on my way back."
"I'm sorry, is that an objection?" The blonde gritted his teeth. Blackmail was a bitch. "Because I could've sworn I said no objections, right? Take whatever ride you got here from."
"I didn't take a ride. I walked."
"Well, if your place is close enough to walk and mine is far enough that I need a motorcycle, I think it's apparent who needs the umbrella more. Not that there's any room to debate, servant boy." Good lord, how did he ever think he was anything NEAR perfect? The rain started to fall harder and the teen held a hand out. "Hurry up."
Roxas would question why he was soaked, but Ventus could always dry himself off before he got home. "Here," he murmured, shoving it out in front of him.
He took it, "Good." He turned to leave while Ventus figured he truly was the biggest idiot on Earth.
"Wait!" he held his hand out, insinuating for him to stop. "When am I gonna get that back?"
"When you pick it up from my house."
"I don't know where your house is!" Ven exclaimed, "I don't even know your name!"
He gave one last sideways glance over his shoulder, "I guess you'll have to figure it out then."
Ventus stared forward until the teen faded from eyesight, becoming a black blur. He might as well have sported wicked black wings and a speared tail because as far as Ventus was concerned, he just sold his soul to the devil.
What just happened?
His feet slapped the cement as the bottoms of his skinny jeans were soaking up more and more water. The rain was pouring down now as he ran home and he didn't even bother trying to shield his hair with his hand anymore. "Oh, my god!" he reached the front door of the house and swung it open, panting.
He hugged himself in attempt to bring back the warmth he had lost from the cold wind outside and dropped his bag down on the floor before making his way upstairs. Taking off his wet clothes, he put on a dry attire and went to the bathroom to blow dry the dripping locks. "I can't believe this," he unplugged the device when he was done and gave his hair a shake before staring at himself in the mirror. He could barely come to terms with what just happened. Maybe it was just some dumb dream and he really didn't wake up that morning. Maybe if he got back in the bed, he'd wake up back to reality.
Ventus considered it was reasonable enough. More reasonable than becoming some stranger's slave. He went back into his room and threw the covers on his bed to the side as he climbed under them. Laying his head down on his pillow, his lids covered his eyes. If he just went to sleep, he'd wake up and it'd all be different...
A/n: Well, how was it? :D I just love VanVen & honestly I think they need more love! I want to get to the yaoi so bad, but I won't rush a story. But don't worry it's coming. In the mean time, please review/comment! They're greatly welcomed and appreciated! I'll answer all reviews next chapter since I've found out I get some good questions & comments from you all :D


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subset: commoncrawl


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Practice Area: Workers compensation
Outcome: Undocumented workers Entitled to Workers Comp
Description: In 2007, Ms. Castrillon went before the Honorable Judge Kathryn Pecko in a trial to ensure the right to benefits of illegal immigrants who are injured while working. In this important case, a young man fell off a roof while working for a local roofing company. His employer knew that he was not legally able to work in the United States and paid him cash for his work. However, when he was injured, his employer's insurance company tried to hide behind the fact that he was an illegal alien to deny him his right to medical care and monetary benefits for lost wages. Ms. Castrillon successfully argued that the Employer cannot use his immigration status as both a shield and a sword. They used his illegal status to be able to pay him reduced wages without tax consequences but then tried to use this same fact against him to deny him benefits when he fell down while working for them. Now, thanks to the efforts of Ms. Castrillon, this is the precedent in Broward County and her argument is being used by other attorneys in other counties in Florida.


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Lucy Pinder Biography
- Age: 33 years old
- Birth Nation: United Kingdom
- Height: 5 Feet 4 Inch
- Name: Lucy Pinder
- Birth Name: Lucy Katherine Pinder
- Nationality: British
- Birth Place/City: Winchester, Hampshire, England, UK
- Profession: Acting, Modeling
- Net Worth: $3 Million USD
- Body Measurements: 32-24-30 (Bust-Waist-Hip)
- Breast Size: 32 D
- Waist size: 24 in
- Hip Size: 30 in
- Neck Size: 8.7
- Shoe Size: 8
- Weight in KG: 53 kg
- Married: Unmarried 14
The hot, sexy and glamorous, Lucy Pinder has made her mark in the modeling arena with her curvy body and mostly due to her voluptuous breasts. The Stunning "Nuts" favorite , Lucy Pinder has been seen on many magazine covers looking steamy and topless. Lucy has also been enlisted as one of the FHM 100 Sexiest Women in the world in the 2005 UK edition. Needless to say her beauty has mesmerized the male gender the most due to the plentiful cover shots in numerous issues of men's magazines. Lucy Pinder is not only recognized as a model but also as an actor. Lucy has been seen in a few films and has made many TV appearances in Dream Team, Book at Bedtime with Lucy Pinder, Celebrity Big Brother and many more. Lucy Pinder was also noted as the Most Downloaded Woman on the Internet in 2007.
Born on December 20 1983 in Winchester, Hampshire, England, little Lucy Katherine Pinder had no knowledge about what was to follow, she had no intention of becoming a model. At the tender age of 17 Lucy was accepted into Cambridge where she studied Political Science. She later changed her subject to Philosophy and started dating the Black rugby player Clyde. Lucy also revealed that on her first final term paper she earned an "A" by writing on the "social problems that occur with your friends and family when your boyfriend is black". In August 2003 Lucy was spotted by a freelance photographer Lee Earle while she and one of her friend were sunbathing on Bournemouth beach. Lucy agreed to the photographer's request of taking a picture and in no time by age 18 lucy signed a professional modeling contract with the Daily Star tabloid newspaper.
Lucky as it may sound, this British girl with voluptuous breast was already posing for various magazines and journals including first and foremost –Nuts, Zoo Weekly, Busty Brits and Boob Journal. With her all-natural 32GG breasts, Lucy Pinder was ruling in the Modeling industry. In the 2005 UK edition of the FHM 100 Sexiest Women in the World, Lucy was enlisted as no.16. Lucy posed topless in the UK men's magazine Nuts in the April 2007 edition. Shortly she appeared nude in the "Loaded" magazine. Lucy was voted Daily Star's Favorite Page 3 Girl Of All Time, and of course Nuts' Number One Babe every year since its launch in 2005. Lucy's modeling career was booming and till date she has been seen in more than 50 covers of Nuts magazine and over 200 covers of the Daily Star. Till date Lucy Pinder has more covers and Page 3 appearances in the Daily Star than any other model which is quite obvious. Lucy has also made appearances in promotional ads for PlayStation 2, the Yellow Pages and the National Lottery. In the November 2007 edition of the Australian magazine Ralph, Lucy was officially declared to have the "Best Breasts in the World".
This Babe having a height of five feet and five inches was not only satisfied by modeling so she tried her hand on acting as well. Thus in 2004 Lucy appeared on Living TV's series I'm Famous and Frightened. Then later on 31 December 2005, Lucy appeared on Sky sports as a celebrity soccerette on Soccer AM. As she supports the Southampton F.C., Lucy wore their jersey. On January 15 2008, Lucy made her debut as a TV presenter for Nuts TV. The audiences were shocked with Lucy's amazing Academy Award nomination for her performance as a gay, Jewish woman who is physically and mentally disabled, progressive liberal during the Holocaust who was also Muslim. In February 2008 Lucy made a cameo appearance with Michelle Marsh in Hotel Babylon on BBC1.Lucy also appeared in the Celebrity Big Brother in 2009 but was the first housemate to be voted out. In 2012 Lucy was seen in the movie Strippers Vs. Werewolves. And Recently Lucy has appeared in the 2014 movie The Seventeenth Kind.
Many people may know Lucy Pinder as a model and an actress but she is a philosopher as well.At the age of 21 Lucy graduated from Cambridge taking along with her a Philosophy degree. Lucy published her ground breaking study on how men tend to objectify and personify a woman's body parts, lucy also discovered that men do not listen to women while they talk , instead they focus on one or several of her desirable body parts. Lucy also put it on paper that at some point in life, men would begin to treat woman's body part as a living creature. This theory was called Female Anatomy Personification commonly known as FAP. For her logic and theories Lucy became a regular contributor to both Nuts Magazine advice column and BBC. Lucy also expanded on that theory at the age of 24, so that they theory be put in school textbooks. Lucy has also freely presented her thoughts regarding her theory in an interview. Lucy's official forum and various sites like wiki present the info about her life as well as her theory. Lately in 2010, Oxford University made Lucy Pinder an official senior member in their institution. Lucy also gives lectures and private sessions to scholars.
Lucy founded her humanitarian foundation Busty Brains. Lucy is active in charity programs as well. Lucy is an eager supporter of charities like Cat protection, MCAC (Male Cancer Awareness Campaign), Tiger Time, Help for Heroes which supports the troops and many more. Lucy was an ambassador for Kick for life , a charity that fought poverty and disease in Third World countries taking football as a medium. Lucy is currently dating Daniel Hooper who is a carpenter. Their affair had started way back in 2002 when they were teenagers and it has been over 13 years now that they are together. Lucy Pinder recently posed topless for the Lucy Pinder 2014 Official Calendar.
- Last modified : 08 August, 2016
- Url: http://articlebio.com/lucy-pinder


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So, this past year, I switched to a heavier duty mascara, and while I'm obsessed with it, Ponds Cold Cream was about the only thing that would take it off.
In the winter, that's great, because my skin is typically dry and could use the extra moisture, but when summer rolls around, it's not ideal.
I knew there were eye make-up removers on the market I could use in tandem with another cleanser, but that sounded like a lot of work. I really wanted an all-in-one to be sure I'd actually use it. You can imagine my delight when I heard* of Micellar Cleansing Water by Garnier Fructis. Basically, it's powerful, but is really gentle on your skin. I love how quickly I can wipe off the day's make-up with just a few swipes. It even gets rid of my stubborn mascara. (Did I mention it's under $10?)
Have you tried micellar water? What did you think?
*I read it is "beloved by French make-up artists." Is that true? Either way, it got me to try it.


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Note that you can only get an s rank in the Japanese version of the game.
But if you do have the Japanese version you could do it by going through the game without saving,using any weapon upgrades,no special weapons and use only one herb(no first aid sprays.And the most annoying thing is that you have to complete the game under 1 and a half hour. Pretty tough thing to do if you ask me.


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|Smith residence
|First seen in:
The Smith residence is the home of the Smith Family - which includes Beth, Jerry, Morty, Summer, and Snuffles as well as Beth's father Rick. It is located in Washington state, just outside Seattle.[1]
Rick's primary workshop is contained in the garage, which contains large amounts of gadgets which are used on many of the duo's adventures.
Rick has been known to expand facilities underneath the property, as well as install features into the house unbeknownst to the rest of the family, such as blast shields (and "kill bots") as security measures.
In the episode "Ricksy Business," The Smith Residence was transported to another dimension, where part of the ground was removed from the earth, leaving a hole in the ground and a huge crack in the driveway. When it came back, the crack and earth shift were still visible and would continue to be in all subsequent episodes.
In the episode "Look Who's Purging Now," Summer launched a rocket through the roof of the garage, leaving a hole in the roof. The roof, under repair, would be visible in all subsequent episodes as well.
Current Residents
Former Residents
- Dining Room
- Living Room
- Kitchen
- Bathroom
- The Garage
- Underground Lair
- Beth and Jerry's Room
- Summer's Room
- Morty's Room
- Rick's Room
- Yard
Episode Absences


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Ultraviolet Radiation and the Skin Immune Response
- Authors
- Publisher
- Sestre Milosrdnice University hospital and Institute of Clinical Medical Research; [email protected]
- Publication Date
- Source
- Legacy
- Keywords
- Disciplines
At present, ultraviolet radiation (UVR) represents one of the most important environmental factors affecting mankind. Besides the beneficial effects of UVR such as vitamin D production, it is known that UVR can lead to adverse effects on human health. The best known harmful effects are sunburns, tumors of the skin and ocular damage. It is noteworthy that UVR effects are not restricted to skin-associated infections, as there is strong evidence for their association with systemic (non-skin-associated) infections as well. Alterations in immune functions that are induced by UVR are initiated by the absorption off light energy by chromophores and their transformation into photoproducts. Some of them are removed by repair mechanisms; others induce signal transduction pathways, whereas some exhibit cytotoxicity. The observable skin response may occur within minutes of light exposure (e.g. urticaria) or may take days (e.g. inhibition of contact hypersensitivity), or much longer periods to be expressed (e.g. tumors). Today, artificial UVR (phototherapy) is used in dermatology for induction of immunomodulation in many forms of autoimmune and/or hyperimmune responses in the skin.


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Boxer Amir Khan (L) of Britain punches Luis Collazo of the U.S. during their welterweight fight at the MGM Grand Garden Arena in Las Vegas.
Children play with yellow coloured paper ships near a memorial altar for victims onboard passenger ship Sewol set up at Seoul City Hall Plaza.
A gust of wind blows off Pope Francis' cap during his weekly general audience at St. Peter's Square at the Vatican.
U.S. First Lady Michelle Obama gives a thumbs up as she takes her seat at the White House Correspondents' Association Dinner in Washington.
Illegal immigrants who were abandoned by traffickers in a remote desert area wait inside a military base in Dongola town, after being located by Sudanese and Libyan forces. The desert area between Sudan and Libya is a major route for illegal immigrants trying to escape Sudan's war-torn regions, with many of them transiting in Libya before trying to flee to Europe across the Mediterranean Sea.
Microsoft founder and technology advisor Bill Gates throws a newspaper during a competition at a trade show at the Berkshire Hathaway annual meeting in Omaha, Nebraska.
A Palestinian protester throws a stone towards an Israeli military bulldozer during a protest against the Jewish settlement of Qadomem, near the West Bank City of Nablus.
A pro-Russian activist aims a pistol at supporters of the Kiev government during clashes in the streets of Odessa, Ukraine.
A villager along with his cow walks through a parched land of a dried pond on a hot day on the outskirts of Bhubaneswar in the eastern Indian state of Odisha.
An oak tree that has lost all its leaves and most of its branches from a tornado is pictured at sunset near Vilonia, Arkansas.
A man wearing an American flag blindfold pretends to read a copy of the U.S. Constitution during protests for immigration and workers rights reform during May Day demonstrations in New York.
Injured children cry after, according to activists, two barrel bombs were thrown by forces loyal to Syria's president Bashar Al-Assad in Hullok neighbourhood of Aleppo May 1, 2014. At least 33 people were killed when Syrian government warplanes attacked a busy market in a rebel-controlled district of Aleppo on Thursday, the Syrian Observatory for Human Rights said.
Protesters shield themselves from police water cannon during a May Day demonstration in Istanbul, Turkey.
Tourist jumps inside an upside-down house at Fengjing Ancient Town, Jinshan District, south of Shanghai, China.
Corinthians soccer club fans cheer over a banner of late Formula One driver Ayrton Senna before the team's Copa do Brasil soccer match against rival club Nacional AM at the Arena Amazonas stadium in Manaus, Brazil.


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Distinctive Models Of Fragrance The big apple Outlets Provide If you're somebody who enjoys fragrances it is a pretty excellent opportunity which you most likely personal numerous perfumes which you utilize in rotation or which you use dependent on your own mood together with the situation. Having said that, obtaining fragrances will likely be somewhat pricy at times, particularly if you choose the top quality scents. For those who happen to are now living in a small town buying quality fragrances might be a bit pricey too, assuming the neighborhood shops provide selections on a variety of perfumes. Do you have to be at any time in Ny, then you certainly now realize that it really is a great spot to hunt up some fragrances you can convey home and luxuriate in. There are many specific types of fragrance Big apple suppliers are renowned for, and also you may want to try these on your own remain in this state. They might even develop special scents completely for you to get pleasure from. It truly is doable you may have to pay a lot more on your individual signature scent but that is certainly typically absolutely definitely worth the revenue also.
Win Victoria's Secret Shopping Spree [www.stylolady.com/victoria-secret.html Victoria's Secret Shopping]
If you'd like to go to shops focusing on quite a few differing kinds of fragrance The big apple features a good offer of those to provide. There are lots of of internet sites that satisfy the wants of men and women wanting to locate great fragrances like you, and all you'll need to accomplish is start a question inside a browser's internet search engine to develop a summary of solutions. In case you would prefer to go to the actual outlets you'll have the ability to search out fragrance specialists likewise, plus they also can guide while using the types of scent which you might choose to get. You'll find cologne's, perfumes, and each type of fragrance Ny stores need to present by investing some time window shopping.
In case you are anxious with regards to the price tag of the specific fragrance Big apple merchants give as you are over a strict spending plan, it is very easy to look for those that market fragrances at sensible charges. There are numerous perfume and cologne merchants which you can go to in Ny. You'll be able to make the decision to visit the stores which provide perfumes and cologne's on sale otherwise you can even possibility on low cost fragrance suppliers where you will get your preferred scents at charges that happen to be fifty percent the primary price tag.
Bear in mind on the other hand that not all low cost fragrance suppliers supply genuine perfumes, and it will be ideal to pick properly among the the ones you will discover. At the time you prospect on reliable perfumes and cologne Big apple shops really have to provide at low cost rates though, you'll be able to wager that the money can go a protracted way into obtaining numerous differing types of cologne's and perfumes that New york provides. Really, there is certainly nothing rather like opening a bottle of fragrance or getting to sniff an ideal scents, and when you've got a fantastic tale to precise on how you learned them at deal prices, that just can make the expertise greater.


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Mandarin Orange Coffee Cake
READY IN: 50mins
Recipe by Jo in Arlington
This makes a super moist bundt cake. I've served it at brunch or as a dessert.
Top Review by Baby Kato
What a lovely recipe Jo in Arlington. I made this cake exactly as written, it was quick and very easy to make with great results. It produced a tall, moist tender cake with little bits of mandarin thru out. We really enjoyed this treat which I sprinkled with a little icing sugar. Thank you for sharing a recipe that we will enjoy again.
See Discussion:3 Reviews
Ingredients Nutrition
- 1 package Duncan Hines Supreme orange cake mix
- 1 (4 ounce) package instant vanilla pudding
- 4 eggs
- 1⁄2 cup vegetable oil
- 1 (11 ounce) can mandarin oranges, reserve juice (add orange juice to make 1 cup)
Directions See How It's Made
- Preheat oven to 350°.
- Grease and flour 10-inch Bundt pan.
- Combine cake mix, pudding mix, eggs, oil, and one-cup juice.
- Beat at medium speed with electric mixer for 2 minutes.
- Add Mandarin oranges in the last 30 seconds.
- Pour in pan.
- Bake 38 to 43 minutes or until toothpick inserted in center comes out clean.
- Cool in pan 10 minutes.
- Invert onto plate.
- Dust with powdered sugar when completely cooled.


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It only takes a minute to get started. Fill out our simple sign up form and login to the website.
This step is optional but will drastically multiply your chances of getting noticed by other people on the website. Write a few sentences about yourself, your interests and attach a nice photograph of yourself.
Use our website's advanced search to encounter members who fulfill your requirements. Or just flip through listings and encounter daters that you find attractive.
Found someone who looks interesting? Send an email to them or just a wink and wait for their response. With a little luck you'll be on your way to a lifetime of happiness.
And start dating


text:
Arimidex in McCune Albright Syndrome
This study has been completed.
Information provided by (Responsible Party):
ClinicalTrials.gov Identifier:
First received: February 25, 2003
Last updated: August 31, 2015
Last verified: August 2015
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
No Study Results Posted on ClinicalTrials.gov for this Study
|Study Status:
|This study has been completed.
|Study Completion Date:
|August 2015
|Primary Completion Date:
|February 2006 (Final data collection date for primary outcome measure)


text:
Find Your Coach
Find out how a coach can help and how to pick a good one. Then use our ADHD Coach listing to find YOUR coach.
For Professionals
Find out more about the ACO, its commitment to evidence-based practices, and the benefits of membership.
For Members
Get the latest news and announcements from the ACO and access your membership benefits.
The ACO is the worldwide professional membership organization for ADHD Coaches.
We are committed to being the outstanding resource for our profession.
Whether you're a coach, looking for help, or just plain curious about ADHD coaching,
we can help you.
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Do you want to know what's going on? If you think you're missing something, you probably are. DON'T MISS OUT ...Learn More
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text:
Here are a few of our favorite upcoming auction items
Charity is BNO's most treasured category of Auctions that allows us to give back.
With BNO's live streaming interactive auction platform, charities can now expand fundraising efforts throughout the year with the potential for worldwide participation (and giving).
Whether it's one auction or a series of regularly scheduled auctions, the BNO auction platform can be utilized at no cost to a charity. This feature dramatically increases the pool of auction participants and, consequently, the amount of funds raised. Our experienced, dynamic auctioneers will also professionally manage the auction portion of each fundraiser event, and in the process, maximize the amount of funds raised for the charity. A miracle, you say? Please, we're way too humble to accept your compliment!
Benefits of a BNO charity auction:
Copyright © 2017 Bid Network Online, Inc. All Rights Reserved.


text:
JACKSON — Gov. Phil Bryant said today that he wants the state to resist any presidential order that might restrict gun rights.
Republican Bryant said he was acting in anticipation of Democratic President Barack Obama issuing executive orders aimed at banning military-style assault weapons, high-capacity ammunition clips.
"I am asking that you immediately pass legislation that would make any unconstitutional order by the President illegal to enforce in Mississippi by state or local law enforcement," Bryant wrote in a letter to Lt. Gov. Tate Reeves and House Speaker Philip Gunn, who are also Republicans.
Bryant said in the letter that he believes any gun-control executive order by Obama "infringes our constitutional right to keep and bear arms as never before in American history."
Mississippi resisted federal authority to enforce voting rights and desegregation during the civil rights era, but Bryant says there's no comparison now.
"We were going the other direction then. We were saying, 'We're standing against the federal government's authority to provide civil liberties,'" Bryant said in response to reporters' questions at the Capitol. "And what we're doing now is saying, 'We're standing against the federal government taking away our civil liberties.' There is a distance between the east and the west on this. And so any association with that, I believe, is baseless."
>>Gov. Bryant remarks to the media on White House gun control order. Click below to view.


text:
No, the products are completely compatible and interchangeable.
Most fences feature galvanised steel posts and COLORBOND® steel infill sheets. Immersing the galvanised steel posts in concrete does not cause any corrosion problems but you should not allow the concrete to contact the rails or infill sheets of the fence. Check with your fencing supplier.
LYSAGHT BONDEK® can be used as formwork and as a reinforcement in composite slabs. It can be used in a wide range of building construction including steel, concrete and masonry framing system with a minimum ground clearance of 450mm. It is typically designed as a one-way slab.
COLORBOND® steel fences should not be installed within 1 kilometre of marine, severe industrial or other corrosive environments.


text:
Most Helpful Girl
they're quite contrasting, I'd go with the first one just because it's more mainstream, if I may throw in a differing option I think this one's striking-- link00|00|0
Have an opinion?
your up to it again lol ;p
Thank you! :) Do oyu have an opinion on them?
The only link that works is the second one in the original part of the question. The rest are Facebook hacks, yikes.
your first link says Facebook hacker? anyways, the dress you picked out does not show enough detail because I can see only the top half but I do like the top half of the gown :) looks traditional and beautiful.
Thank you! I guess I have to refind the other dress
Go with what you think is more beautiful. You know what you want really, you're just afraid to say it. No Regrets for you wedding.
They are both beautiful but I like the first one more. I think the first one would also be better if you are on the smaller side :)
Damn I can see why you're having a hard time deciding ha ha they are both beautiful (: I think if you're slimmer, go for the second one and if you're curvy show those curves off with the first one d;
The second one is very pretty but I couldn't see the first one:)
Thank you!
Thank you! :)
Definitely the last link you posted. It's gorgeous ull look amazing in it. Good luck! ;)
They're both ugly
If you're smaller then the strapless is better for you. It would be VERY easy for the long-sleeved one to over power the wearer, and strapless is flattering on a lot more body types.
Last link you posted.
Facebook hacker wtf :D
Fuuuuuu. :/
You cannot undo this action. The opinion owner is going to be notified and earn 7 XPER points.


text:
|Publication number
|Publication type
|Application number
|Publication date
|Sep 3, 2002
|Filing date
|Jul 2, 2001
|Priority date
|Sep 1, 1998
|Fee status
|Also published as
|Publication number
|Steven M. Lefkowitz, Geraldine Fulcrand, Douglas J. Dellinger, Charles Z. Hotz
|Original Assignee
|Agilent Technologies, Inc.
|Export Citation
|BiBTeX, EndNote, RefMan
|Patent Citations (9), Non-Patent Citations (3), Referenced by (22), Classifications (20), Legal Events (3)
|External Links: USPTO, USPTO Assignment, Espacenet
This is a divisional of application Ser. No. 09/145,015 filed on Sep. 1, 1998 now U.S. Pat. No. 6,258,454.
This invention relates generally to chemical functionalization of surfaces to modify the properties thereof. More particularly, the invention relates to functionalization of a substrate with a silane mixture to reduce surface energy and thus constrain droplets of liquid that are applied to the substrate surface. A primary use of the invention is in the field of solid phase chemical synthesis, particularly solid phase synthesis of oligomer arrays.
Chemically modified, "functionalized," solid surfaces are necessary in many laboratory procedures involved in chemistry and biotechnology. One important application is in solid phase chemical synthesis, wherein initial derivatization of a substrate surface enables synthesis of polymers such as oligonucleotides and peptides on the substrate itself. Support-bound oligomer arrays, particularly oligonucleotide arrays, may be used in screening studies for determination of binding affinity and in diagnostic applications, i.e., to detect the presence of a nucleic acid containing a specific, known oligonucleotide sequence. Modification of surfaces for use in chemical synthesis has been described, for example, in U.S. Pat. No. 5,624,711 to Sundberg et al., in U.S. Pat. No. 5,266,222 to Willis et al., in U.S. Pat. No. 5,137,765 to Farnsworth, and in numerous other patents and publications.
In modifying siliceous or metal oxide surfaces, one technique that has been used is derivatization with bifunctional silanes, i.e., silanes having a first functional group enabling covalent binding to the surface (often an Si-halogen or Si-alkoxy group, as in —SiCl3 or —Si(OCH3)3, respectively) and a second functional group that can impart the desired chemical and/or physical modifications to the surface. A problem with this type of surface modification, however, is that incorporation of a desirable surface chemical functionality—provided by the second functional group—may result in a surface with undesirable physical properties. For example, there is currently a great deal of interest in synthesizing arrays of different oligonucleotides on siliceous surfaces, and a high density of array features is generally considered desirable. The various array features can be independently created by the planar separation of individual phosphoramidite coupling reactions as the oligonucleotides are synthesized; a simple way to achieve this separation is by spotting the phosphoramidite solutions onto the surface. Feature density is then determined by the spread of the solution droplet, which is in turn uniquely determined by both the volume of the droplet and the contact angle between the droplet and the surface. However, to covalently couple the first nucleotide phosphoramidite to the substrate surface requires hydroxyl moieties on the surface, which makes the surface wettable by the phosphoramidite solutions and thus creates droplet spread; for a given droplet volume, then, relatively large array features are provided, limiting feature density.
The aforementioned problem can be overcome using a variety of techniques to constrain the droplets as they are applied to the substrate surface. Permanent wells can be formed by micromachining the substrate, with the active surfaces subsequently modified, constraining the droplet by capillary action. Temporary wells can also be formed using either a pre-formed "stencil" or by applying a coating to the substrate and patterning the coating. These wells could constrain the droplet by either capillary action and/or by using a relatively unwettable coating. Alternatively, as described in U.S. Pat. No. 5,474,796 to Brennan, a pattern of two different surface-bound silanes can be formed by physically masking the surface, depositing the first silane, and then removing the mask and depositing the second silane. This procedure can be used to constrain a droplet by surrounding a reactive spot on the surface, formed by one of the two silanes, with a lower surface energy spot, formed by the other of the two silanes.
All of these procedures, however, require considerable processing and thus add substantially to the time and cost required to fabricate an array. Also, the existence of a pattern on the substrate requires that the array writing apparatus be aligned with the surface pattern, a non-trivial issue for small array features.
The present invention is directed to the aforementioned need in the art, and provides a way of functionalizing substrate surfaces to reduce surface energy and thus constrain droplets of liquid that are applied to the substrate surface, while avoiding the aforementioned problems and difficulties associated with the procedures of the prior art.
Accordingly, it is a primary object of the invention to address the aforementioned need in the art and provide a relatively simple, straightforward process for preparing a low surface energy functionalized surface on a substrate.
It is an additional object of the invention to provide such a process by coupling a mixture of silanes to hydrophilic moieties present on a substrate surface.
It is another object of the invention to provide a process for preparing support-bound cleavable ligands on a low surface energy substrate, wherein the ligands may be small molecules, oligonucleotides, oligopeptides, or the like.
It is another object of the invention to provide a derivatizing composition for preparing a low surface energy functionalized surface on a substrate.
It is still another object of the invention to provide such a derivatizing composition comprising a mixture of silanes.
It is yet another object of the invention to provide such a derivatizing composition comprising a first silane that upon binding to a substrate reduces the surface energy thereof, and a second silane that upon binding to a substrate provides a means for covalently binding molecular moieties to the substrate surface.
It is a further object of the invention to provide substrates having low surface energy functionalized surfaces.
Additional objects, advantages and novel features of the invention will be set forth in part in the description which follows, and in part will become apparent to those skilled in the art upon examination of the following, or may be learned by practice of the invention.
In one embodiment of the invention, then, a process is provided for preparing a low surface energy functionalized surface on a substrate, which comprises contacting a substrate having reactive hydrophilic moieties on its surface with a derivatizing composition comprising a first silane R1—Si(RLRxRy) and a second silane R2—(L)n—Si(RLRxRy) under reaction conditions effective to couple the silanes to the substrate surface and provide —Si—R1 groups and —Si—(L)n—R2 groups thereon. The RL, which may be the same or different, are leaving groups, the Rx and Ry, which may also be the same or different, are either leaving groups, like RL, or are lower alkyl, R1 is a chemically inert moiety that upon binding to the substrate surface lowers the surface energy thereof, n is 0 or 1, L is a linking group, and R2 comprises either a functional group enabling covalent binding of a molecular moiety or a group that may be modified to provide such a functional group. The ratio of the silanes in the derivatizing composition determines the surface energy of the functionalized substrate and the density of molecular moieties that can ultimately be bound to the substrate surface.
In another embodiment, a process is provided for preparing support-bound cleavable ligands on a low surface energy substrate. The process involves contacting a substrate having reactive hydrophilic moieties on the surface thereof with a derivatizing composition comprising a first silane R1—Si(RLRxRy) and a second silane R2—(L)n—Si(RLRxRy) as described above, under reaction conditions effective to couple the silanes to the substrate surface and provide —Si—R1 groups and —Si—(L)n—R2 groups thereon. A ligand is then coupled to the surface at R2, through a linking moiety containing a cleavable site. The ligand may be, for example, a small molecule, a first monomer in the solid phase synthesis of an oligomer, an intact oligomer, or the like.
In an additional embodiment, a derivatizing composition is provided for carrying out the aforementioned processes. The derivatizing composition comprises a mixture of silanes, including a first silane R1—Si(RLRxRy) and a second silane R2—(L)n—Si(RLRxRy), wherein R1, R2, RL, Rx, Ry and n are as defined above.
Finally, the functionalized substrates provided using the presently disclosed and claimed processes and compositions represent a further embodiment of the invention. The substrates have surface-bound —Si—R1 groups and —Si—(L)n—R2 groups, wherein the R1 moieties reduce surface energy and the R2 moieties comprise either functional groups enabling covalent attachment of a molecular moiety of interest or modifiable groups that can be converted to such functional groups.
FIG. 1 schematically illustrates the functionalization of a substrate surface with a derivatizing composition comprising 97.5 wt. % n-decyltrichlorosilane ("NDS") and 2.5 wt. % undecenyltrichlorosilane ("UTS"), as described in Example 1.
FIG. 2 is a graph showing the dependence of surface hydroxyl content on the mole ratio of UTS in the UTS/NTS derivatizing composition, evaluated as described in Example 2.
FIG. 3 illustrates, in graph form, the increase in contact angle for various derivatizing compositions, including a derivatizing composition of the invention, as described in Example 2.
FIG. 4 is a graph showing the general relationship between spot diameter and contact angle, again, as described in Example 2.
Overview and Definitions
Before describing the present invention in detail, it is to be understood that this invention is not limited to specific compositions, reagents, process steps, or equipment, as such may vary. It is also to be understood that the terminology used herein is for the purpose of describing particular embodiments only, and is not intended to be limiting.
It must be noted that, as used in this specification and the appended n claims, the singular forms "a," "an" and "the" include plural referents unless the context clearly dictates otherwise. Thus, reference to "a first silane having the structural formula R1—Si(RLRxRy)" includes mixtures of silanes having the recited structure, while, similarly, a second silane having the structural formula R2—(L)n—Si(RLRxRy)" includes mixtures of such silanes, "a cleavable site" includes a multiplicity of cleavable sites, and the like.
In describing and claiming the present invention, the following terminology will be used in accordance with the definitions set out below.
The term "functionalization" as used herein relates to modification of a solid substrate to provide a plurality of functional groups on the substrate surface. By a "functionalized surface" as used herein is meant a substrate surface that has been modified so that a plurality of functional groups are present thereon.
The terms "reactive hydrophilic site" or "reactive hydrophilic group" refer to hydrophilic moieties that can be used as the starting point in a synthetic organic process. This is contrast to "inert" hydrophilic groups that could also be present on a substrate surface, e.g, hydrophilic sites associated with polyethylene glycol, a polyamide or the like.
The "surface energy" γ (measured in ergs/cm2) of a liquid or solid substance pertains to the free energy of a molecule on the surface of the substance, which is necessarily higher than the free energy of a molecule contained in the in the interior of the substance; surface molecules have an energy roughly 25% above that of interior molecules. The term "surface tension" refers to the tensile force tending to draw surface molecules together, and although measured in different units (as the rate of increase of surface energy with area, in dynes/cm), is numerically equivalent to the corresponding surface energy. By modifying a substrate surface to "reduce" surface energy is meant lowering the surface energy below that of the unmodified surface.
The term "monomer" as used herein refers to a chemical entity that can be covalently linked to one or more other such entities to form an oligomer. Examples of "monomers" include nucleotides, amino acids, saccharides, peptoids, and the like. In general, the monomers used in conjunction with the present invention have first and second sites (e.g., C-termini and N-termini, or 5′ and 3′ sites) suitable for binding to other like monomers by means of standard chemical reactions (e.g., condensation, nucleophilic displacement of a leaving group, or the like), and a diverse element which distinguishes a particular monomer from a different monomer of the same type (e.g., an amino acid side chain, a nucleotide base, etc.). The initial substrate-bound monomer is generally used as a building-block in a multi-step synthesis procedure to form a complete ligand, such as in the synthesis of oligonucleotides, oligopeptides, and the like.
The term "oligomer" is used herein to indicate a chemical entity that contains a plurality of monomers. As used herein, the terms "oligomer" and "polymer" are used interchangeably, as it is generally, although not necessarily, smaller "polymers" that are prepared using the functionalized substrates of the invention, particularly in conjunction with combinatorial chemistry techniques. Examples of oligomers and polymers include polydeoxyribonucleotides, polyribonucleotides, other polynucleotides which are—or C-glycosides of a purine or pyrimidine base, polypeptides, polysaccharides, and other chemical entities that contain repeating units of like chemical structure. In the practice of the instant invention, oligomers will generally comprise about 2-50 monomers, preferably about 2-20, more preferably about 3-10 monomers.
The term "ligand" as used herein refers to a moiety that is capable of covalently or otherwise chemically binding a compound of interest. Typically, when the present substrates are used in solid phase synthesis, they are used so that "ligands" are synthesized thereon. These solid-supported ligands can then be used in screening or separation processes, or the like, to bind a component of interest in a sample. The term "ligand" in the context of the invention may or may not be an "oligomer" as defined above. However, the term "ligand" as used herein may also refer to a compound that is not synthesized on the novel functionalized substrate, but that is "pre-synthesized" or obtained commercially, and then attached to the substrate.
The term "sample" as used herein relates to a material or mixture of materials, typically, although not necessarily, in fluid form, containing one or more components of interest.
The terms "nucleoside" and "nucleotide" are intended to include those moieties which contain not only the known purine and pyrimidine bases, but also other heterocyclic bases that have been modified. Such modifications include methylated purines or pyrimidines, acylated purines or pyrimidines, or other heterocycles. In addition, the terms "nucleoside" and "nucleotide" include those moieties that contain not only conventional ribose and deoxyribose sugars, but other sugars as well. Modified nucleosides or nucleotides also include modifications on the sugar moiety, e.g., wherein one or more of the hydroxyl groups are replaced with halogen atoms or aliphatic groups, or are functionalized as ethers, amines, or the like.
As used herein, the term "amino acid" is intended to include not only the L-, D- and nonchiral forms of naturally occurring amino acids (alanine, arginine, asparagine, aspartic acid, cysteine, glutamine, glutamic acid, glycine, histidine, isoleucine, leucine, lysine, methionine, phenylalanine, proline, serine, threonine, tryptophan, tyrosine, valine), but also modified amino acids, amino acid analogs, and other chemical compounds which can be incorporated in conventional oligopeptide synthesis, e.g., 4-nitrophenylalanine, isoglutamic acid, isoglutamine, ε-nicotinoyl-lysine, isonipecotic acid, tetrahydroisoquinoleic acid, α-aminoisobutyric acid, sarcosine, citrulline, cysteic acid, t-butylglycine, t-butylalanine, phenylglycine, cyclohexylalanine, β-alanine, 4-aminobutyric acid, and the like.
The terms "protection" and "deprotection" as used herein relate, respectively, to the addition and removal of chemical protecting groups using conventional materials and techniques within the skill of the art and/or described in the pertinent literature; for example, reference may be had to Greene et al., Protective Groups in Organic Synthesis, 2nd Ed., New York: John Wiley & Sons, 1991. Protecting groups prevent the site to which they are attached from participating in the chemical reaction to be carried out.
The term "alkyl" as used herein refers to a branched or unbranched saturated hydrocarbon group of 1 to 24 carbon atoms, such as methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, t-butyl, octyl, decyl, tetradecyl, hexadecyl, eicosyl, tetracosyl and the like, as well as cycloalkyl groups such as cyclopentyl, cyclohexyl and the like. The term "lower alkyl" intends an alkyl group of 1 to 6 carbon atoms, preferably 1 to 4 carbon atoms.
The term "alkoxy" as used herein refers to a substituent —O—R wherein R is alkyl as defined above. The term "lower alkoxy" refers to such a group wherein R is lower alkyl.
The term "alkylene" as used herein refers to a difunctional saturated branched or unbranched hydrocarbon chain containing from 1 to 24 carbon atoms, and includes, for example, methylene (—CH2—), ethylene (—CH2—CH2—), propylene (—CH2—CH2—CH2—), 2-methylpropylene (—CH2—CH(CH3)—CH2—), hexylene (—(CH2)6—), and the like. "Lower alkylene" refers to an alkylene group of 1 to 6, more preferably 1 to 4, carbon atoms.
The terms "alkenyl" and "olefinic" as used herein refer to a branched or unbranched hydrocarbon group of 2 to 24 carbon atoms containing at least one carbon-carbon double bond, such as ethenyl, n-propenyl, isopropenyl, n-butenyl, isobutenyl, t-butenyl, octenyl, decenyl, tetradecenyl, hexadecenyl, eicosenyl, tetracosenyl and the like.
The terms "halogen" or "halo" are used in the conventional sense to refer to a chloro, bromo, fluoro or iodo substituent.
"Optional" or "optionally" means that the subsequently described circumstance may or may not occur, so that the description includes instances where the circumstance occurs and instances where it does not. For example, the phrase "optionally substituted" means that a non-hydrogen substituent may or may not be present, and, thus, the description includes structures wherein a non-hydrogen substituent is present and structures wherein a non-hydrogen substituent is not present.
Accordingly, the invention in a first embodiment is directed to a process for preparing a low surface energy functionalized surface on a substrate. The functionalized surface prepared using this process has functional groups enabling covalent binding of molecular moieties, such as in solid phase chemical synthesis or the like, but nevertheless has lowered surface energy so that wettability is reduced and liquid droplets applied to the substrate surface are constrained (i.e., do not spread to the extent that they would in the absence of the presently disclosed and claimed surface modification process).
The inventive process involves contacting the surface of a solid substrate with a derivatizing composition that contains a mixture of silanes, under reaction conditions effective to couple the silanes to the substrate surface via reactive hydrophilic moieties present on the substrate surface. The reactive hydrophilic moieties on the substrate surface are typically hydroxyl groups, carboxyl groups, thiol groups, and/or substituted or unsubstituted amino groups, although, preferably, the reactive hydrophilic moieties are hydroxyl groups. The substrate may comprise any material that has a plurality of reactive hydrophilic sites on its surface, or that can be treated or coated so as to have a plurality of such sites on its surface. Suitable materials include, but are not limited to, supports that are typically used for solid phase chemical synthesis, e.g., cross-linked polymeric materials (e.g., divinylbenzene styrene-based polymers), agarose (e.g., Sepharose�), dextran (e.g., Sephadex�), cellulosic polymers, polyacrylamides, silica, glass (particularly controlled pore glass, or "CPG"), ceramics, and the like. The supports may be obtained commercially and used as is, or they may be treated or coated prior to functionalization.
The derivatizing composition contains two types of silanes, a first silane that may be represented as R1—Si(RLRxRy) and a second silane having the formula R2—(L)n—Si(RLRxRy). In these formulae, the RL, which may be the same or different, are leaving groups, the Rx and Ry, which may be the same or different, are either lower alkyl or leaving groups like RL, R1 is a chemically inert moiety that upon binding to the substrate surface lowers the surface energy thereof, n is 0 or 1, L is a linking group, and R2 is a functional group enabling covalent binding of a molecular moiety or a group that may be modified to provide such a functional group. Reaction of the substrate surface with the derivatizing composition is carried out under reaction conditions effective to couple the silanes to the surface hydrophilic moieties and thereby provide —Si—R1 groups and —Si—(L)n—R2 groups on the substrate surface.
More specifically, the RL moieties, which are leaving groups, are such that they enable binding of the silanes to the surface. Typically, the leaving groups are hydrolyzable so as to form a silanol linkage to surface hydroxyl groups. Examples of suitable leaving groups include, but are not limited to, halogen atoms, particularly chloro, and alkoxy moieties, particularly lower alkoxy moieties. The Rx and Ry are either lower alkyl, e.g., methyl, ethyl, isopropyl, n-propyl, t-butyl, or the like, or leaving groups as just described with respect to RL. Thus, each type of silane will generally contain a trichlorosilyl functionality, a tri(lower)alkoxysilyl functionality such as trimethoxysilyl, mixed functionalities such as diisopropylchlorosilyl, dimethylchlorosilyl, ethyldichlorosilyl, methylethylchlorosilyl or the like.
The first silane is the derivatizing agent that reduces surface energy as desired, while the second silane provides the surface functionalization necessary for covalent attachment of an additional molecular moiety, e.g., a ligand, a monomer, an oligomer, etc. Thus, with respect to the first silane, coupling to the substrate yields surface —Si—R1 groups as explained above, wherein R1 is a chemically inert moiety that upon binding to the substrate surface lowers surface energy. By "chemically inert" is meant that R1 will not be cleaved or modified when the functionalized substrate is used for its intended purpose, e.g., in solid phase chemical synthesis, hybridization assays, or the like. Typically, R1 is an alkyl group, generally although not necessarily containing in the range of 2 to 24 carbon atoms, preferably in the range of 10 to 18 carbon atoms. R1 may also be benzyl, either unsubstituted or substituted with 1 to 5, typically 1 to 3, halogen, preferably fluoro, atoms.
The second silane, upon coupling, provides surface —Si—(L)n—R2 groups. Of course, if the Rx and Ry are not leaving groups, the surface moieties provided will actually be "—SiRxRy—(L)n—R2" groups, which applicants intend to encompass by the more generic representation "—Si—(L)n—R2". R2 comprises either a functional group that can bind directly to an additional molecular species of interest, or a modifiable group that can be converted to such a functional group under conditions that do not substantially affect any other chemical species that are present. That is, R2 may be a functional group such as hydroxyl, carboxyl, amino, or the like, or it may be a modifiable group such an olefinic moiety, e.g., a terminal —CH═CH2 group, which can readily be converted to a reactive hydroxyl group by boration and oxidation using procedures known in the art. L represents a linker and n is 0 or 1, such that a linker may or may not be present. If a linker is present, it will generally be a C1-C24 hydrocarbylene linking group. Normally, L is C1-C24 alkylene, preferably C10-C18 alkylene.
The density of R2 groups on the substrate surface, following reaction with the derivatizing composition, is determined by the relative proportions of the first and second silanes in the derivatizing composition. That is, a higher proportion of the second silane in the derivatizing composition will provide a greater density of R2 groups, while a higher proportion of the first silane will give rise to a lower density of R2 groups. Optimally, the first silane represents in the range of approximately 0.5 wt. % to 50 wt. % of the derivatization composition, preferably in the range of approximately 1.0 wt. % to 10 wt. % of the composition, while the second silane correspondingly represents in the range of approximately 50 wt. % to 99.5 wt. % of the derivatization composition, preferably in the range of approximately 90 wt. % to 99 wt. % of the composition.
Functionalized substrates prepared using the aforementioned procedures are believed to be novel and are claimed as such herein. The surface of the functionalized substrates contain both —Si—R1 and Si—(L)n—R2 groups, present at a predetermined ratio, with the ratio determining both surface energy and density of functional groups. These substrates may be used, for example, in any of a number of known chemical and biological procedures, such as in solid phase chemical synthesis, e.g., of oligonucleotides, oligopeptides, and oligosaccharides, in the preparation of combinatorial libraries, in chemical separation procedures, in screening processes, and the like. Such procedures are in current use and will thus be known to those skilled in the art and/or described in the pertinent literature and texts. For example, synthesis of polynucleotide libraries using now conventional phosphoramidite or phosphotriester chemistry is described by Beaucage et al. (1981) Tetrahedron Lett. 22:1859-62, and Itakura et al. (1975) J. Biol. Chem. 250:4592 (1975). Houghten (1985) Proc. Natl. Acad. Sci. USA 82:5131-5135), describes the preparation of a combinatorial library of peptides using a modification of the Merrifield method (Merrifield (1963) J. Am. Chem. Soc. 85:2149-2154; Tam et al., The Peptides (New York: Academic Press, 1975), at pp. 185-249); and Oligonucleotide Synthesis, M. J. Gait, Ed. (New York: IRL Press, 1990).
For example, synthesis of support-bound oligonucleotides is normally conducted by successive addition of protected nucleotides to a growing oligonucleotide chain, wherein the terminal 5′ hydroxyl group is caused to react with a deoxyribonucleoside-3′-O-(N,N-diisopropylamino)phosphoramidite protected at the 5′ position with dimethoxytrityl or the like, the 5′ protecting group is removed after the coupling reaction, and the procedure is repeated with additional protected nucleotides until synthesis of the desired oligonucleotide is complete.
Additionally, and as will be appreciated by those skilled in the art, oligopeptide synthesis on a support—as may be carried out herein by virtue of the support-bound R2 substituent—involves sequential addition of carboxyl-protected amino acids to a growing peptide chain, with each additional amino acid in the sequence similarly protected and coupled to the terminal amino acid of the oligopeptide under conditions suitable for forming an amide linkage. After oligopeptide synthesis is complete, acid is used to remove the remaining terminal protecting groups. The support-bound oligopeptides thus provided can then be used in any number of ways, e.g., in screening procedures involved in combinatorial processes, in chromatographic methods, and the like.
In an alternative embodiment, the method and reagents of the invention are used to provide oligomers bound to the support via a chemically cleavable site. That is, in this alternative process, following reaction of the substrate surface with the first and second silanes, a further reaction is conducted at R2. This reaction involves reaction of R2 with a linking group containing a cleavable site, such as an ester group, and the free terminus of the bound linking group is then used for solid phase synthesis. Conversion of R2 to a different moiety may or may not be desired prior to attaching the linking group. For example, R2 may be an alkylamino substituent, in which case the amino moiety serves as the reactive site for binding the linking group, or R2 may be bromo, in which case it is desirable to convert R2 to a primary or secondary amino substituent, and then carry out the reaction to the linking group. In this way, the bound ligand, monomer, oligomer, or the like may be cleaved from the solid support by treatment of the surface with an appropriate reagent.
Suitable cleavable sites include, but are not limited to, the following: base-cleavable sites such as esters, particularly succinates (cleavable by, for example, ammonia or trimethylamine), quaternary ammonium salts (cleavable by, for example, diisopropylamine) and urethanes (cleavable by aqueous sodium hydroxide); acid-cleavable sites such benzyl alcohol derivatives (cleavable using trifluoroacetic acid), teicoplanin aglycone (cleavable by trifluoroacetic acid followed by base), acetals and thioacetals (also cleavable by trifluoroacetic acid), thioethers (cleavable, for example, by HF or cresol) and sulfonyls (cleavable by trifluoromethane sulfonic acid, trifluoroacetic acid, thioanisole, or the like); nucleophile-cleavable sites such as phthalamide (cleavable with substituted hydrazines), esters (cleavable with, for example, aluminum trichloride) and Weinreb amide (cleavable with lithium aluminum hydride); and other types of chemically cleavable sites, including phosphorothioate (cleavable with silver or mercuric ions) and diisopropyldialkoxysilyl (cleavable with fluoride ion). Other cleavable sites will be apparent to those skilled in the art or are described in thge pertinent literature and texts (e.g., Brown (1997) Contemporary Organic Synthesis 4(3):216-237).
It is to be understood that while the invention has been described in conjunction with the preferred specific embodiments thereof, the foregoing description as well as the example that follows are intended to illustrate and not limit the scope of the invention. Other aspects, advantages and modifications within the scope of the invention will be apparent to those skilled in the art to which the invention pertains.
All patents and publications mentioned herein, both supra and infra, are hereby incorporated by reference.
Preparation of Functionalized Surfaces
This example describes functionalization of a glass substrate with a derivatizing composition comprising 97.5 wt. % n-decyltrichlorosilane ("NTS") as a first silane and 2.5 wt. % undecenyltrichlorosilane ("UTS") as a second silane, followed by boration and oxidation to convert the terminal olefinic moiety of the surface-bound UTS to a hydroxyl group. This procedure is shown schematically in FIG. 1. Evaluation of the functionalized surface is also described.
(a) Silylation:
Under moisture-free conditions, 14 ml NTS and 0.4 ml UTS were added to 800 ml of anhydrous toluene, and swirled to mix. Cleaned glass substrates were placed into a ca. 1 liter reactor equipped for inert gas purging, heating and stirring, and purging was conducted for 30 minutes. Moisture-free conditions were maintained, and the NTS/UTS solution was added to the reactor. The solution was heated to 100� C. for 4 hours, while stirring and continuing to maintain moisture-free conditions. The silane solution was removed from the reactor and replaced with anhydrous toluene. This step was repeated twice.
The substrates were then removed from the reactor and rinsed rigorously with an appropriate solvent. The bulk solvent was removed from the substrates by blowing with clean inert gas. The substrates were placed in a vacuum oven preheated to 150� C. and heated under vacuum for 1 hour. The substrates were removed and allowed to cool to ambient temperature.
(b) Boration and Oxidation:
The silylated substrates prepared in part (a) were placed in a ca. 1 liter reactor equipped for inert gas purging and stirring, and purging was conducted for 30 minutes. Under moisture-free conditions, 800 ml of 1.0 M borane-tetrahydrofuran complex was transferred to the reactor. The substrates were incubated while stirring, for two hours. Then, while maintaining moisture-free conditions, the boration solution was removed and replaced with 800 ml anhydrous tetrahydrofuran. The substrates were removed and rinsed rigorously with an appropriate solvent. Bulk solvent was removed by blowing with clean inert gas.
To a 1 liter vessel equipped for stirring, 800 ml of 0.1 N NaOH in 30% hydrogen peroxide (aqueous) was added. The oxidized substrates were immersed therein, and incubated, with stirring, for 10 minutes. The substrates were removed and rinsed rigorously with an appropriate solvent, then dried by blowing with clean inert gas.
The processes of steps (a) and (b) were repeated using different mole ratios of NTS and UTS, 100% UTS, and a mixture of glycidoxypropyl trimethoxysilane and hexaethylene glycol (GOPS-HEG). This hydroxyl silane-linker was prepared following the procedure of Maskos et al. (Maskos et al. (1992) Nucleic Acids Res. 20:1679) who demonstrated it to be useful for both oligonucleotide synthesis and hybridization.
Evaluation of Functionalized Surfaces
Surface hydroxyl density (molecules/μm2) of the functionalized surfaces prepared in Example 1 was evaluated spectrophotometrically, and FIG. 2 shows the dependence of surface hydroxyl content on the mole ratio of UTS in the UTS/NTS derivatizing composition. FIG. 3 shows the increase in contact angle for several UTS mole ratios and two solvents of interest, acetonitrile and adiponitrile, in comparison to a GOPS-ethanol mixture. Contact angles reported are static contact angle measurements as described in the literature (Chan, Chi-Ming, Polymer Surface Modification and Characterization, chapter 2 (New York: Hansa Publishers, 1993). Measurements were performed on 25 μl aliquots of the appropriate solvent using an FTA200 instrument (First Ten Angstroms, South San Francisco, Calif.). FIG. 4 shows the general relationship between the spot diameter and contact angle. For 100 nl drops, the following spot diameters were observed for the GOPS-ethanol mixture and the 2.5% UTS/NTS derivatizing composition:
Thus, the derivatizing composition of the invention significantly reduces spot diameter for a droplet of a given volume.
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Year of fee payment: 12


text:
Suresh Gopi is a proud father. His son about to make his debut as an actor is an exciting prospect, but this is more exciting because his daughter had already got her share of the limelight, when she made her debut as a singer. Her song in the movie 'Jo we Lo' had a warm reception.
Gokul makes his debut in the movie 'Muthugow' produced by Vijay Babu and Sandra Thomas, under the banner of Friday Film House. The production house follows their usual trend of getting a debutant director for their venture. The movie conceived by Vipin Das is going to be the eighth debutant director for the production house. The movie introduces actress Ardhana as well. One of the producers, Vijay Babu,is also set to appear in a key role.
The movie is a light hearted comedy and romantic entertainer, with Gokul receiving a light role as well. His father had come in through negative roles, later went on to become an action superstar and took up comedy roles at a latter stage of his career. Though it is too early in his career to judge, this role will surely turn out to be a revelation on what his potential is.
He is not the first one to have up to the standards that their fathers had set. With Pranav Mohanlal and Kalidas coming in as child artists, and later Dulquer Salman entering into their fathers' territory, they had to cope with the pressure of expectations too. Out of the three Superstars' progeny only Dulquer has yet come out of his father's shadow, with Pranav taking up cinematography and direction, and Kalidas only taking his first steps without his father to look out for him, it is Gokul's turn to step up.With the first look released, all eyes are on him.
Gokul Suresh Makes His Debut In The Movie Muthugow – First Look Revealed
Featured 20/03/2016


text:
After Work Martinis
On Friday the 9th of November at 5:00pm until 8:00pm Singles Who Click invites you to come and take pleasure in after work martinis as you mingle with the sexy singles at the famous Paris Cat jazz club. Located at Basement 6 Goldie Place (on the corner of Queen and Lonsdale Street), Melbourne. You can sit back relax and have a drink whilst listening to fabulous live jazz and enjoying the delicious finger food provided.
Tickets can be pre booked for $10 by calling Flirt Connections on 9846 4402
Tickets can also be purchased at the door for $15
For more information visit www.singleswhoclick.com.au or call Flirt Connections on 9846 4402


text:
|Message view
|« Date » · « Thread »
|« Date » · « Thread »
|Thomas Müller <thomas.muel...@day.com>
|Re: Reindexing a workspace ...
|Mon, 15 Jun 2009 09:49:58 GMT
Hi, If you use database persistence managers and a database journal, you could use the following procedure: 1) stop the cluster node 2) backup the lucene index, config files, and revision.log of this cluster node 3) later on, backup the persistence manager data, journal data, and data store This backup should be consistent because the journal includes the list of changes, so the lucene index is updated. Regards, Thomas On Tue, Jun 9, 2009 at 3:48 PM, KÖLL Claus<firstname.lastname@example.com> wrote: > hi (thomas), > > your post was clear thanks for the info ... > ok the lucene index is consistent but you will not get a snapshot from the repository > as bart wrote. > > I see some problems with barts solution .. > if you have a large repository a write lock that runs hours is not good > but maybe some others have good ideas ... > > i have tested the environment as you mentioned with the cluster and it works fine at the > moment for us because we can re-index the backup cluster in the background if we get > a crash ... hopefully not :-) > > greets > claus >
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text:
Why would a guy always look sad when looking at a girl? Then when he talks to her he is always mean and trying to get a reaction?
Why would a guy always look sad when looking at a girl? Then when he talks to her he is always mean and trying to get a reaction?
Have an opinion?
What Guys Said 2
Sounds like a depressed guy who likes a girl, but due to his negative outlook has decided she'll reject him and is already lashing out at her for what he imagines she would do. It's his way to have power over people he assumes would wrong him.
Avoid those guys at all costs.00|00|0
Do you see that as crazy/psychopath
I think it's a sign of depression, and if you don't already know the guy, there's no reason to hang out with him.
He might be seriously mentally ill, or he might be just having a bad day, but acting like you describe with someone you don't know is a good reason to avoid him.
What if he doesn't know how to express himself properly. He might be reserved and choose to just play out his approach in his head. When he does get an opportunity he get a little loud because he wants to be heard or maybe this is his method of attention seeking.00|00|0
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text:
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Be the first guy to share an opinion
and earn 1 more Xper point!
They want others to know of their accomplishments. They put in the hard work and effort, so it's nice if others recognize it at times. Some people like to brag, too.
some are proud and worked bloody hard for their achievements, so they do have bragging rights.
others just want to rub it in people's faces, or they have a superiority complex about them.
it's hard to tell when u dont know the intention.
I can understand it being obnoxious but sometimes its really hard not to be proud and share your achievements
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