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Republican presidential candidate Patrick J. Buchanan strongly favored a plan of "covert operations" to harass and embarrass Democratic contenders in the heady days at the Nixon White House before the Watergate scandal.
Then a White House speechwriter and enthusiastic member of the Nixon campaign's "attack group," Buchanan laid out his ideas in an April 10, 1972, memo looking ahead to that summer's Democratic National Convention in Miami Beach. It was addressed to Attorney General John N. Mitchell and White House Chief of Staff H.R. Haldeman.
On the memo's last page -- one never turned over to Watergate congressional investigators -- Buchanan and his top aide recommended staging counterfeit attacks by one Democrat on another, fouling up scheduled events, arranging demonstrations and spreading rumors to plague the rival party, all the while being careful not to run afoul of the Secret Service.
Buchanan denied in testimony before the Senate Watergate committee in 1973 that he was aware of any "covert operations" that the GOP had sponsored for the Democratic convention.
It is unclear whether the last page of the four-page memo, composed by Buchanan and his chief aide Ken Khachigian, was ever sent. But it shows how the blunt-spoken Buchanan felt about political espionage against the Democrats. It also indicates that he knew that covert operations were being "directed" out of the White House "as they have been in the past."
Now a contender for the GOP nomination, Buchanan was an aggressive, outspoken defender of President Richard M. Nixon during the Watergate scandal but was never caught up in it, in contrast to individuals such as Haldeman and Mitchell, who were convicted in the coverup.
In addition to his speechwriting work, Buchanan was in charge of "opposition research" for the Nixon White House and was, as he put it in one memo, a "regular and enthusiastic member of the campaign 'Attack Group' " that met regularly to discuss 1972 political strategy.
A spokesman for Buchanan's presidential campaign declined to comment Saturday on the April 10, 1972, memo. Buchanan was in Atlanta yesterday with more than seven hours of "downtime" on his schedule, but the spokesman, K.B. Forbes, said he had no intention of disturbing the candidate.
"We're focusing on a national presidential campaign," Forbes said. "Pulling out the 'golden oldies' from 20 years ago is irrelevant." He said "downtime" for Buchanan "means he's untouchable."
On the campaign trail these days, Buchanan, 57, makes only passing references to his time at the Nixon White House. He joined Nixon in 1966 when the former vice president was planning his comeback and stayed with him until Nixon resigned in August 1974. But Buchanan is rarely asked about the experience as he hops from state to state and he rarely speaks about it.
The 1972 document, as well as others offering a glimpse of Buchanan's White House work, are in the custody of the National Archives, preserved under a 1974 law designed to protect records of historical significance and to "provide the public with the full truth, at the earliest reasonable date, of the abuses of governmental power popularly identified under the generic term 'Watergate.' "
Despite that mandate, many of the Nixon records are still tied up as a result of objections by the late president's lawyers and many more, including Buchanan's papers before 1971, have yet to be processed.
His April 10, 1972, memo began by proposing creation of an overt and hard-hitting outpost in Miami Beach to take advantage of "running sores" at the forthcoming Democratic convention there.
It said the outpost -- which Buchanan planned to head -- should be made public and should spend almost all of its time with the national press. "Anyone at the Observation Post should be clean as a hound's tooth -- and the Observation Post should have no hand in any 'covert operations' ongoing in Miami," it said.
Eventually, in the wake of the Watergate break-in and coverup, the memo was among records subpoenaed by Senate investigators for an inquiry into alleged sabotage and "dirty tricks" during the 1972 campaign. White House counsel told Buchanan not to produce his political memos, but Senate lawyers obtained what they thought was a complete copy of the April 1972 document by serving another subpoena on the Committee to Re-Elect the President, popularly known as CREEP.
Only three pages were produced. The Senate Watergate committee never learned that there was a fourth page. On it, Buchanan and Khachigian proposed:
"COVERT OPERATIONS -- We should have as many of these down there [at Miami Beach] as needed to conduct harassment exercises, and embarrassment exercises for the Democrats. They should have no connection at all with the GOP Observation Post, and should be directed out of here, as they have been in the past.
"They should be able to help put demonstrations together, get leaflets out, start rumors, and generally foul up scheduled events -- and add to the considerable confusion and chaos that will inevitably exist."
It continued:
"The preparation of attacks on one Democrat by another -- and 'endorsements' of one Democrat by another, which has to be repudiated, are examples of what can be done. Nothing should be done here, incidentally, which can seriously backfire and anything done should be cleared by the highest campaign authority. The Secret Service, it should be noted, will be all over Miami; and any activity will have to take into consideration their capabilities.
"We should guard here against a) anything which enables the Democrats to blame us for the mess which takes place in Miami Beach; b) anything which can be traced back to us and c) anything which is so horrendous as to damage us, if the hand is discovered."
The memo was labeled "CONFIDENTIAL" and contains typographical errors indicating it was a draft. It was among the Buchanan papers once relegated to the Nixon White House's "special files unit," a section that maintained files considered sensitive because of their political content or security classification.
Asked about the three-page version of the memo at a Sept. 26, 1973, Senate Watergate committee hearing, Buchanan said the observation post was never set up at the convention "because, frankly, of the Watergate incident and apprehension on my part" that the Democrats would have accused those manning the post of being spies. He envisioned the post, operating out of the Fontainebleau Hotel, as being headed by two "politically savvy" spokesmen, one of them a "tough cop" to counterattack the Democrats and the other a "nice cop" to praise the president's record "and to answer, more in sorrow than in anger, the charges being elevated" by the Democrats.
The Watergate break-in at Democratic National Committee offices took place on June 17, 1972. The bitterly contested Democratic convention at Miami Beach, ending with the nomination of Sen. George S. McGovern (D-S.D.), was held July 10-13.
In preparation for the convention, G. Gordon Liddy, subsequently convicted of the Watergate burglary, laid out an elaborate covert operations plan, "Operation Gemstone," at a Jan. 17, 1972, Justice Department meeting with Attorney General and Nixon campaign director Mitchell, White House counsel John Dean and deputy campaign director Jeb S. Magruder.
His proposals included CRYSTAL, an electronic surveillance to be directed at the Democratic convention from an opulent houseboat; SAPPHIRE, a spying caper relying on prostitutes working out of a lush houseboat bedroom, wired for sound [the ceiling was too low for an overhead camera]; and TURQUOISE, a disruption scheme relying on what Liddy called "a commando team of Cubans" to sabotage all of the convention hall's air-conditioning units.
At the January meeting, Mitchell rejected the scheme as too expensive. But on April 1, Liddy has said, Magruder finally conveyed approval of a $250,000 "Gemstone" budget, including two prostitutes, four spies in the Democratic camps and a series of surreptitious break-ins.
The arrest of five men at the Watergate in the early morning hours of June 17 apparently derailed the rest of "Gemstone" and led instead to a long coverup culminating in Nixon's resignation in August 1974.
The Buchanan-Khachigian memo of April 10, 1972, makes no mention of "Gemstone" or any other code word and, on its face, cautions against anything "so horrendous as to damage us, if the hand is discovered." It also says that "anything done should be cleared by the highest campaign authority."
Terry Lenzner, former assistant chief counsel for the Senate Watergate committee, said on learning of the memo last week that it was more reminiscent of the separate program of "dirty tricks" directed against Democratic presidential candidates in the 1972 primaries by individuals such as White House-hired political saboteur Donald H. Segretti.
With funds supplied by Nixon's personal lawyer, Segretti crisscrossed the country under assumed names, planting spies, disrupting rallies and creating divisiveness among the Democrats with false press releases, bogus letters and fake ads. After plea bargaining, he drew a six-month prison term for fabricating literature in the Florida primary. One was a letter on the campaign stationery of Sen. Edmund S. Muskie (D-Maine) accusing Sens. Henry M. Jackson (D-Wash.) and Hubert H. Humphrey (D-Minn.) of sexual misconduct.
Minor Republican rivals such as then-Rep. Pete McCloskey (R-Calif.) were also fair game in Buchanan's view. His White House papers include a Dec. 15, 1971, memo to Haldeman and Mitchell outlining "an anti-McCloskey campaign in New Hampshire." One idea, Buchanan said, would be to find a way of getting a gay rights group or the Black Panthers or the radical Students for a Democratic Society at Dartmouth "to contribute a grand or so to the McCloskey campaign" and then alert the highly conservative Manchester Union Leader about the donation.
The three-page version of the April 10, 1972, memo that was given to the Senate Watergate Committee was accompanied by a cover memo, dated April 12, 1972, from Magruder to Mitchell, recommending approval. The attorney general checked "Approve," added the phrase "subject to comments," and initialed it.
Buchanan dominated the 1973 Senate hearing, playing, as one commentator put it, "the dirtiest trick a witness can play on televised senators -- he made them look like a bunch of nitpickers. For every supposed political dirty trick they asked him about, he had either an explanation, a denial of involvement or a similar example from the lore of Democratic politics."
At one point, the committee's chief counsel, Sam Dash, asked Buchanan: "Were you aware of the covert activities sponsored by the Republican Party for the Democratic National Convention during . . . the convention?"
Buchanan responded: "Was I aware of any? No, I was not aware of any. I would trust we had some intelligence people down at Miami Beach to see how they handled their convention -- that is a gigantic affair -- how they handled their press, how they handled their demonstrations . . . but this was not my function."
He was asked only briefly about the April 10 memo. "I did recommend a forward observation post," Buchanan said.
"But you recommended that it be kept clear or clean, away from any covert operations?" Dash said.
"Right," Buchanan replied. "There were 2,000 press in Miami Beach. I certainly hope we had people down there demonstrating for Richard Nixon. But anything like that should be kept away from the observation post, we should be clean as a hound's tooth out of apprehension at the allegations made against us so we could say flatly, no, we had nothing to do with X, Y or Z."
No one asked him about his endorsement of covert operations because no questioner at the hearing knew about page 4 of the memo. Lenzner said he was unaware of its existence until Friday when a reporter asked him about it. "We assumed we were given the entire document," Lenzner said.
Staff researcher Alice Crites contributed to this report.


text:
Passo del Cerreto rankings
Difficulty ranking world: 2761 (all)
Ranking Italy: 788 (all)
Ranking Apennines: 152(all)
Difficulty score: 77.91 what?
Passo del Cerreto ratings
(3.7) Overall
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The Passo del Cerreto is situated in Tuscany. This climb belongs to the Apennines.
Starting from Fivizzano,
the Passo del Cerreto ascent is 18.8 km long. Over this distance, you climb 935 heightmeters.
The average percentage thus is 5 %.
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subset: commoncrawl


text:
In 2017 we're hosting the 10th Bergen Swim Festival, and we're inviting you to join in on our celebration! It is an honour to again host a great swim meet in Alexander Dale Oen Arena. We look forward to celebrating 10 years of great swimming and a lot of fun. The swim meet is approved by the Norwegian Swimming Federation (NSF) and organized by their rules and regulations.
AdO arena Fina approved 5m - 10 lanes. Pool temperature ca. 27º C.
Electonic timing and online live timing.
Age dispensation from NSF.
Disabled: Competing by Austrailian model. Participants ranked by world record in each class.
The best swimmers are swimming in the first three heats in the preliminaries. Finals organized by class, except 800 and 1500 meter, that are organized as super finals (no prelims) with the 8 fastest registered swimmers.
In the case of fewer than 8 registered participants, everyone is automatically qualified for the finals.
50 m arranged as knock out heats, except 50 crawl which is organized through semi-finals and finals.
8 fastest swimmers in each class qualifiy to the finals. 3 heats in each class, 3 slowest swimmers leave after heat one, 2 swimmers leave after the second heat. The final three swimmers swim in heat three. A minimum of 3. min. between each race.
N.B: Heat limitation as described in event program
See Event Setup
Super finals: NOK 3000,-, 1250,- og 750,- in cash
Senior: NOK 3000,-, 1250,- og 750,- in cash.
Junior: NOK 500,-, 300,- og 200,- in cash.
Disabled: NOK 500,-, 300,- og 200,- in cash.
Best overall performances according to FINA-2016 listings achieved during finals gets following prize money (only one prize per participant):
1. place NOK 10.000,-
2. place NOK 5.000,-
3. place NOK 2.500,-
1. place NOK 5.000,-
2. place NOK 2.500,-
3. place NOK 1.250,-
AdO arena Friday at 08.00 am.
|2.00pm - 9.00pm
|08.00-09.45 am and 3.30-4.30 pm
|08.00-09.45 am and 3.30-4.30 pm
|07.00-08.45 am and 2.30-3.45 pm
Friday 16.30.
|prelims 10am Finals 5pm
|prelims 10am Finals 5pm
|prelims 9am Finals 4pm
Meet office is open every day and is located next to the Reception area at the pool entrance. Results and information: bsf.no
BSF 2017 has been approved by FINA as a qualification meet for the WC in Budapest.
Deadline for entries:
Tuesday April 18th at 24.00
Entry times are best times achieved between April 19th 2016 - April 18th 2017.
Stipulated time is allowed if the swimmer haven't swum the event in this time period. In case of limited heat entries, stipulated times are seeded last.
Entry forms accepted through Stevnebørsen / PRIMA-format or Grodan. Alternatively in Word/Excel, e-mailed to: email@example.com.
NOK 100,- per individual event to be paid in total by each team.
Bergen Swim Festival
Account no. 9521.34.41257
postboks 1342, Vika
0113 Oslo
Manager: Finn Zachariassen
Tel: +47 920 28 992
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Erica Russell
Music and News Writer/Weekend Editor for PopCrush. Follow Erica on Twitter @neonandnoise
Lorde premiered a brand new song, 'Sober,' during a pre-Coachella show in the desert on Friday, April 14.
Watch The Chainsmokers perform on the April 8 episode of 'SNL.'
New reports allege that Mel B's ex, Stephen Belafonte, physically abused and sexually exploited the singer during their ten year marriage.
Demi Lovato made out with a pillow featuring Ed Sheeran's face on 'The Tonight Show' during an 'Ew!' sketch with Jimmy Fallon.
Jodie Sweetin's ex-fiance Justin Hodak was reportedly arrested for violating a restraining order Sweetin had taken out against him.
Actor Antonio Banderas shared that he experienced a heart attack back in January.
Reality star Jon Gosselin will make his debut as a stripper in Atlantic City in April.
Katy Perry was honored with the National Equality Award for her pro-LGBTQ work.
From the good—Emma Watson and the music—to the beastly—LeFou's 'gay moment' joke and the jarring CGI objects, one lifelong Disney fan reviews 2017's 'Beauty and the Beast.'
Emma Watson is pursuing legal action against hackers who stole and leaked private, non-nude photos of the actress online.
'Beauty and the Beast' director Bill Condon weighs in on Lindsay Lohan's desire to play Ariel in 'The Little Mermaid.'
J. Lo and A-Rod are reportedly in a relationship.
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This personal suite is a typical example of living accommodation at Sunrise of Guildford. As with all our suites – including those designed for couples – private en-suite facilities are included.
* How to navigate through virtual tour: It is a 360-degree, interactive tour showcasing Sunrise Senior Living's care home. You can navigate around the virtual tour by simply dragging, clicking and zooming in or out with your computer mouse. For the best viewing experience, please click the button at the top right hand corner to enter into full screen mode.


text: Welcome to Drago's Survivor Series Add Imagealt= Retrieved from "http://dragossurvivor.wikia.com/wiki/Drago%27s_Survivor_Wiki?oldid=4097" Ad blocker interference detected! Wikia is a free-to-use site that makes money from advertising. We have a modified experience for viewers using ad blockers Wikia is not accessible if you've made further modifications. Remove the custom ad blocker rule(s) and the page will load as expected. Categories: Browse Add category Cancel Save Mayhem Weapons Summer Sci-Fi Adam Ruins


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text: 5. Gleacher & Company ( GLCH) is an investment bank offering advisory services to companies and institutional investors. It also provides capital-raising, sales and trading services. For first-quarter 2011, the company's revenue was $94.7 million as compared to $79.3 million in the earlier-year quarter, led by fixed-income revenue and revenue related to ClearPoint, a mortgage company it acquired in January 2011. Net income for the quarter stood at $7.2 million, or 6 cents per share, as compared to a net loss of $211,000, or nil per share, in the year-ago quarter. During the quarter, the company launched its residential mortgage banking initiative through ClearPoint and earned $5.4 million in principal transactions and commissions. Also, $900,000 was recorded in fees and other revenue due to fees earned on mortgage-lending services. Gleacher recorded $2.3 million as bargain purchase gain in the ClearPoint acquisition. Of the five analysts covering the stock, 40% recommended it as a buy while 40% rate it a hold. The stock's average 12-month price target is $3.2, or 69.3% higher than the current price, analysts polled by Bloomberg say. Prev 6 of 11 Next


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Institute National Of Sante Et Of Recherche Medicale
Institute National Of Sante Et Of Recherche Medicale
Borgers H.,Biomedical science Group |
Moens L.,Biomedical science Group |
Picard C.,Institute National Of Sante Et Of Recherche Medicale |
Picard C.,University of Paris Descartes |
And 9 more authors.
Clinical Immunology | Year: 2010
We evaluated a multiplexed bead-based assay (xMAP® Pneumococcal Immunity assay from Luminex) for the simultaneous determination of antibodies against 14 capsular polysaccharides. Post-vaccination (Pneumovax®) antibody concentrations were measured in 35 healthy children, 40 healthy adults, 99 consecutive patients with increased susceptibility to respiratory infection, and 24 patients with a deficient anti-polysaccharide antibody response. The serotype-specific lower 5th percentile (cutoff) value for the post-immunization antibody concentration was determined in healthy individuals. Eleven of 99 patients (11%) failed to mount a response that was > 5th percentile of controls for at least 6 of the 14 serotypes tested, whereas only 3 of 75 controls (4%) failed to do so. All patients with known anti-polysaccharide antibody deficiency failed to mount a response that was > 5th percentile of controls for at least 6 of the 14 serotypes tested. The XMAP® pneumococcal immunity panel appears useful for identifying individuals with a low response to the unconjugated pneumococcal vaccine. © 2009 Elsevier Inc. All rights reserved.
Fourcade J.,University of Pittsburgh |
Sun Z.,University of Pittsburgh |
Pagliano O.,University of Pittsburgh |
Guillaume P.,University of Lausanne |
And 6 more authors.
Cancer Research | Year: 2012
Cytotoxic T cells that are present in tumors and capable of recognizing tumor epitopes are nevertheless generally impotent in eliciting tumor rejection. Thus, identifying the immune escape mechanisms responsible for inducing tumor-specific CD8 + T-cell dysfunction may reveal effective strategies for immune therapy. The inhibitory receptors PD-1 and Tim-3 are known to negatively regulate CD8 + T-cell responses directed against the well-characterized tumor antigen NY-ESO-1. Here, we report that the upregulation of the inhibitory molecule BTLA also plays a critical role in restricting NY-ESO-1-specific CD8 + T-cell expansion and function in melanoma. BTLA-expressing PD-1 +Tim-3 - CD8 + T cells represented the largest subset of NY-ESO-1-specific CD8 + T cells in patients with melanoma. These cells were partially dysfunctional, producing less IFN-γ than BTLA - T cells but more IFN-γ, TNF, and interleukin-2 than the highly dysfunctional subset expressing all three receptors. Expression of BTLA did not increase with higher T-cell dysfunction or upon cognate antigen stimulation, as it does with PD-1, suggesting that BTLA upregulation occurs independently of functional exhaustion driven by high antigen load. Added with PD-1 and Tim-3 blockades, BTLA blockade enhanced the expansion, proliferation, and cytokine production of NY-ESO-1-specific CD8 + T cells. Collectively, our findings indicate that targeting BTLA along with the PD-1 and Tim-3 pathways is critical to reverse an important mechanism of immune escape in patients with advanced melanoma. ©2011 AACR.
Detante O.,Institute National Of Sante Et Of Recherche Medicale |
Detante O.,Joseph Fourier University |
Valable S.,Institute National Of Sante Et Of Recherche Medicale |
Valable S.,Joseph Fourier University |
And 18 more authors.
Stem Cells Translational Medicine | Year: 2012
Human mesenchymal stem cells (hMSCs) have strong potential for cell therapy after stroke. Tracking stem cells in vivo following a graft can provide insight into many issues regarding optimal route and/or dosing. hMSCs were labeled for magnetic resonance imaging (MRI) and histology with micrometer-sized superparamagnetic iron oxides (M-SPIOs) that contained a fluorophore. We assessed whether M-SPIO labeling obtained without the use of a transfection agent induced any cell damage in clinical-grade hMSCs and whether it may be useful for in vivo MRI studies after stroke. M-SPIOs provided efficient intracellular hMSC labeling and did not modify cell viability, phenotype, or in vitro differentiation capacity. Following grafting in a rat model of stroke, labeled hMSCs could be detected using both in vivo MRI and fluorescent microscopy until 4 weeks following transplantation. However, whereas good label stability and unaffected hMSC viability were observed in vitro, grafted hMSCs may die and release iron particles in vivo. © AlphaMed Press.
PubMed | Institute National Of Sante Et Of Recherche Medicale
Type: Evaluation Studies | Journal: European journal of pediatrics | Year: 2012
West syndrome or infantile spasms is one of the most frequent epileptic syndromes in the first year of life. The clinical symptoms of infantile spasms are very different than any other type of seizure because of both the absence of paroxysmal motor phenomena (i.e., as in a convulsion) and the lack of significant duration of loss of consciousness (i.e., as in absence epilepsy). Infantile spasms may lead to misdiagnosis by pediatricians and other primary care providers. We assessed the missed diagnoses prior to the diagnosis of infantile spasms. We hypothesized that a delay in treatment may have consequences on neurologic outcome. We conducted a multicenter, retrospective, observational study to evaluate occurrence of misdiagnosis and its possible consequences. We performed a multivariate analysis to evaluate the risk for the outcome 2years after the diagnosis of infantile spasms. We included 83 infants over a 5-year period. The majority of consulted physicians (301 of 362) did not suggest any specific diagnosis while the others suggested gastroesophageal reflux (7%), constipation (7%), or colitis (3%). Results indicated that a poor outcome was related to a delay in diagnosis, which was observed regardless of the existence of cognitive involvement prior to the start of infantile spasms (Relative Risk: RR 12.08 [1.52-96.3]). These results highlight the importance of making an early diagnosis of infantile spasms.
PubMed | Institute National Of Sante Et Of Recherche Medicale
Type: Evaluation Studies | Journal: Clinical cancer research : an official journal of the American Association for Cancer Research | Year: 2010
NY-ESO-1 (ESO), a tumor-specific antigen of the cancer/testis group, is presently viewed as an important model antigen for the development of generic anticancer vaccines. The ESO(119-143) region is immunodominant following immunization with a recombinant ESO vaccine. In this study, we generated DRB1*0101/ESO(119-143) tetramers and used them to assess CD4 T-cell responses in vaccinated patients expressing DRB1*0101 (DR1).We generated tetramers of DRB1*0101 incorporating peptide ESO(119-143) using a previously described strategy. We assessed ESO(119-143)-specific CD4 T cells in peptide-stimulated postvaccine cultures using the tetramers. We isolated DR1/ESO(119-143) tetramer(+) cells by cell sorting and characterized them functionally. We assessed vaccine-induced CD4(+) DR1/ESO(119-143) tetramer(+) T cells ex vivo and characterized them phenotypically.Staining of cultures from vaccinated patients with DR1/ESO(119-143) tetramers identified vaccine-induced CD4 T cells. Tetramer(+) cells isolated by cell sorting were of T(H)1 type and efficiently recognized full-length ESO. We identified ESO(123-137) as the minimal optimal epitope recognized by DR1-restricted ESO-specific CD4 T cells. By assessing DR1/ESO(119-143) tetramer(+) cells using T cell receptor (TCR) chain variable region (V)-specific antibodies, we identified several frequently used V. Finally, direct ex vivo staining of patients CD4 T cells with tetramers allowed the direct quantification and phenotyping of vaccine-induced ESO-specific CD4 T cells.The development of DR1/ESO(119-143) tetramers, allowing the direct visualization, isolation, and characterization of ESO-specific CD4 T cells, will be instrumental for the evaluation of spontaneous and vaccine-induced immune responses to this important tumor antigen in DR1-expressing patients.
PubMed | Institute National Of Sante Et Of Recherche Medicale
Type: Journal Article | Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology | Year: 2010
The purpose of this study was to assess the direct effect of CCL18, a chemokine elevated in allergic diseases and induced by Th2 cytokines, on the polarization of human CD4(+) T cells. Purified human T cells from healthy subjects were pretreated or not with CCL18, and evaluated for cytokine production. CCL18-pretreated memory but not naive CD4(+) T cells exhibited an increased production of IL-10 (12.3 2.6 vs. 5.6 0.9 ng/ml for medium) and TGF-1 but not IL-4, IFN-, and IL-17 compared with control cells. Pretreatment of highly purified CD4(+)CD25(-) memory T cells with CCL18 led to their conversion to CD4(+)CD25(+)Foxp3(+) regulatory T cells able to inhibit the proliferation of CD4(+)CD25(-) effector T cells by both cytokine and cell contact-dependent mechanisms. However, this regulatory effect of CCL18 was lost when T cells originated from allergic subjects in relation with a decreased binding of CCL18 to these cells [0.7 0.3 mean fluorescence intensity (MFI)] as compared to those from healthy subjects (6.0 1.7 MFI). This study is the first to define a chemokine that generates adaptive regulatory T cells from CD4(+)CD25(-) memory T cells. This mechanism appears defective in allergic patients and may underlie the decreased tolerance observed in allergic diseases.
PubMed | Institute National Of Sante Et Of Recherche Medicale
Type: | Journal: Journal of visualized experiments : JoVE | Year: 2012
Our goal is to obtain a comprehensive description of molecular processes occurring at cellular membranes in different biological functions. We aim at characterizing the complex organization and dynamics of the plasma membrane at single-molecule level, by developing analytic tools dedicated to Single-Particle Tracking (SPT) at high density: Multiple-Target Tracing (MTT). Single-molecule videomicroscopy, offering millisecond and nanometric resolution, allows a detailed representation of membrane organization by accurately mapping descriptors such as cell receptors localization, mobility, confinement or interactions. We revisited SPT, both experimentally and algorithmically. Experimental aspects included optimizing setup and cell labeling, with a particular emphasis on reaching the highest possible labeling density, in order to provide a dynamic snapshot of molecular dynamics as it occurs within the membrane. Algorithmic issues concerned each step used for rebuilding trajectories: peaks detection, estimation and reconnection, addressed by specific tools from image analysis. Implementing deflation after detection allows rescuing peaks initially hidden by neighboring, stronger peaks. Of note, improving detection directly impacts reconnection, by reducing gaps within trajectories. Performances have been evaluated using Monte-Carlo simulations for various labeling density and noise values, which typically represent the two major limitations for parallel measurements at high spatiotemporal resolution. The nanometric accuracy obtained for single molecules, using either successive on/off photoswitching or non-linear optics, can deliver exhaustive observations. This is the basis of nanoscopy methods such as STORM, PALM, RESOLFT or STED, which may often require imaging fixed samples. The central task is the detection and estimation of diffraction-limited peaks emanating from single-molecules. Hence, providing adequate assumptions such as handling a constant positional accuracy instead of Brownian motion, MTT is straightforwardly suited for nanoscopic analyses. Furthermore, MTT can fundamentally be used at any scale: not only for molecules, but also for cells or animals, for instance. Hence, MTT is a powerful tracking algorithm that finds applications at molecular and cellular scales.
PubMed | Institute National Of Sante Et Of Recherche Medicale
Type: Journal Article | Journal: Breast cancer research and treatment | Year: 2011
Germline mutations in BRCA1/2 confer a high risk of breast cancer (BC), but the magnitude of this risk varies according to various factors. Although controversial, there are data to support the hypothesis of allelic-risk heterogeneity. We assessed variation in BC risk according to the location of mutations recorded in the French study GENEPSO. Since the women in this study were selected from high-risk families, oversampling of affected women was eliminated by using a weighted Cox-regression model. Women were censored at the date of diagnosis when affected by any cancer, or the date of interview when unaffected. A total of 990 women were selected for the analysis: 379 were classified as affected, 611 as unaffected. For BRCA1, there was some evidence of a central region where the risk of BC is lower (codons 374-1161) (HR=0.59, P=0.04). For BRCA2, there was a strong evidence for a region at decreased risk (codons 957-1827) (HR=0.35, P=0.005) and for one at increased risk (codons 2546-2968) (HR=3.56, P=0.01). Moreover, we found an important association between radiation exposure from chest X-rays and BC risk (HR=4.29, P<10(-3)) and a positive association between smoking more than 21 pack-years and BC risk (HR=2.09, P=0.04). No significant variation in BC risk associated with chest X-ray exposure, smoking, and alcohol consumption was found according to the location of the mutation in BRCA1 and BRCA2. Our findings are consistent with those suggesting that the risk of BC is lower in the central regions of BRCA1/2. A new high-risk region in BRCA2 is described. Taking into account environmental and lifestyle modifiers, the location of mutations might be important in the clinical management of BRCA mutation carriers.
PubMed | Institute National Of Sante Et Of Recherche Medicale
Type: Journal Article | Journal: American journal of physiology. Heart and circulatory physiology | Year: 2011
We examined structure, composition, and endothelial function in cerebral arterioles after 4 wk of chronic renal failure (CRF) in a well-defined murine model (C57BL/6J and apolipoprotein E knockout female mice). We also determined quantitative expression of endothelial nitric oxide synthase (eNOS), phosphorylated eNOS (on serine 1177 and threonine 495), and caveolin-1; quantitative expression of markers of vascular inflammation or oxidative stress [Rock-1, Rock-2, VCAM-1, and peroxisome proliferator-activated receptor- (PPAR)]; and the plasma concentration of L-arginine and asymmetric dimethylarginine (ADMA). Our hypothesis was that endothelial function would be impaired in cerebral arterioles during CRF following either a decrease in NO production (through alteration of eNOS expression or regulation) or an increase in NO degradation (due to oxidative stress or vascular inflammation). Endothelium-dependent relaxation was impaired during CRF, but endothelium-independent relaxation was not. CRF had no effect on cerebral arteriolar structure and composition. Quantitative expressions of eNOS, eNOS phosphorylated on serine 1177, caveolin-1, Rock-1, Rock-2, and VCAM-1 were similar in CRF and non-CRF mice. In contrast, quantitative expression of PPAR (which exercises a protective role on blood vessels) was significantly lower in CRF mice, whereas quantitative expression of eNOS phosphorylated on the threonine 495 (the inactive form of eNOS) was significantly higher. Lastly, the plasma concentration of ADMA (a uremic toxin and an endogenous inhibitor of eNOS) was elevated and plasma concentration of L-arginine was low in CRF. In conclusion, endothelial function is impaired in a mouse model of early stage CRF. These alterations may be related (at least in part) to a decrease in NO production.
PubMed | Institute National Of Sante Et Of Recherche Medicale
Type: Journal Article | Journal: Diabetes | Year: 2010
Maturity onset diabetes of the young type 3 (MODY3) is a consequence of heterozygous germline mutation in HNF1A. A subtype of hepatocellular adenoma (HCA) is also caused by biallelic somatic HNF1A mutations (H-HCA), and rare HCA may be related to MODY3. To better understand a relationship between the development of MODY3 and HCA, we compared both germline and somatic spectra of HNF1A mutations.We compared 151 somatic HNF1A mutations in HCA with 364 germline mutations described in MODY3. We searched for genotoxic and oxidative stress features in HCA and surrounding liver tissue.A spectrum of HNF1A somatic mutations significantly differed from the germline changes in MODY3. In HCA, we identified a specific hot spot at codon 206, nonsense and frameshift mutations mainly in the NH(2)-terminal part, and almost all amino acid substitutions were restricted to the POU-H domain. The high frequency of G-to-T tranversions, predominantly found on the nontranscribed DNA strand, suggested a genotoxic mechanism. However, no features of oxidative stress were observed in the nontumor liver tissue. Finally, in a few MODY3 patients with HNF1A germline mutation leading to amino acid substitutions outside the POU-H domain, we identified a different subtype of HCA either with a gp130 and/or CTNNB1 activating mutation.Germline HNF1A mutations could be associated with different molecular subtypes of HCA. H-HCA showed mutations profoundly inactivating hepatocyte nuclear factor-1alpha function; they are associated with a genotoxic signature suggesting a specific toxicant exposure that could be associated with genetic predisposition.


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Izmir is a region in Turkey which is packed with magic and mystery in which you can explore its many interesting sights. It lies in the Gulf of Izmir within the Aegean Sea so you can guarantee fantastic weather for at least 7 months of the year. On the coastal resorts of the Aegean and Mediterranean Seas the summers, between May to October are very acrid, hot and dry. The summer temperatures can reach a staggering 40oC so sun protection is essential.
Izmir is Turkey's 3rd biggest city and is steeped in history and wonder. Its architecture is astounding and the city has many fine mosques, in particular the Hisar Mosque. The Clock Tower in Konak Square is a famous tourist attraction and well worth a visit for some photographic souvenirs. The most popular resorts in the region of Izmir are Cesme, Foca, Izmir, Kusadasi and Ozdere. The ancient name for the city was originally Smyrna, but today it is more popularly known as Izmir.
There are places in Izmir that are still traditional, yet others where life is much more modern. Izmir has an amazing history, together with some splendid beaches, natural beauty, ancient sites, lakes and some fantastic landscapes.
You will be amazed by the smells and sounds as you wander around the streets of Izmir. You will take much delight in its many markets and bazaars that sell lots of oils and spices, as we said the smells are delicious. In the larger towns you will find some cosmopolitan shopping too. Izmir has plenty of shops selling all kinds of items, designer boutiques with the latest fashions, leather shops where you can buy a bargain handbag or sandals, local craft shops and much more.
Izmir is popular for its night venues with both holidaymakers and locals alike. There is a wide variety of bars, clubs and discos which provide a choice of popular music along with some traditional Turkish music and jazz music which is popular amongst the Turkish people. The town of Alsancak is a popular choice with clubbers and those looking for all night entertainment.
If you want to see something traditional like belly dancing, or something more modern like popular music, it is here. You will find a variety of nightlife available but one of the delights of visiting Turkey is to experience that authentic Turkish feel, its music and its culture.
The hospitality of the Turkish people is friendly; they can't do enough to help you. The restaurants serve an amazing mix of traditional Turkish food to something a little more international.
A holiday in Izmir will provide you with historical sights, fantastic scenery, thrills, excitement, water sports, diving, snorkelling, golf, mountain walks and some of the world's finest beaches. There is heaps to do for families and couples alike. You can find a variety of budget, low cost and value for money hotels which won't break your budget.
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Facebook update alert! Your page has changed
- 11 Jun
Facebook update alert! Your page has changed
Facebook has introduced a new look for company business pages, which it describes as being more "streamlined".
The update is designed to make it easier for people to find the information they want and help page admins find the tools they use the most.
Sounds good. But what's actually changed?
The first thing you will see when logged in as an admin is the 'Page Manager' admin tools have gone. Actually, they haven't, they've just moved. However, at first glance, you could be mistaken for thinking so. The large management panel that used to provide an in-depth overview of post details, page activity and personal messages has been replaced by a simplified tab with activity, insights and settings neatly arranged along the top.
This certainly cleans up the page but will require you to actively click on each button to view the analytics results. The benefit, however, is once you do click through, the analytics section has been refined and is more insightful and clearly laid out.
A nice and simple add-on on the right hand side is the "This Week" bar which gives you a quick snapshot of your activities results. It's a nice snapshot, because it arguably displays your most important information e.g. 'is what I'm doing having an impact?' If you roll-over the icons you will receive a detailed breakdown of each of your posts and what content you're putting out there is making a difference.
One of the most distinctive yet subtle changes to business pages is to the timeline. Before the timeline was spread across two columns. Now these two columns still exist, but the content displayed, has changed. Instead of your posts being displayed across both panels, they're now only shown down the right hand column. The benefit of posts appearing on one column is twofold. Firstly, it stops your user's eyeballs being dragged all over the scene by the often incoherent two column structure. Secondly, and most importantly, the return of one column focuses attention back on your content, which is what it's all about.
The left hand column is all about showcasing general information about your business. This includes an about section which will incorporate location, contact details etc. Your photos and apps will also appear here and has helped make the page easier on the eye. The additional and necessary benefit is that it will aid mobile optimisation. However, fundamentally it's not about the left-hand column. These updates are about content. Content is what will benefit your business.
What else should you look out for?
Are you interested in what other businesses are doing and how they compare to yours? The 'Pages to Watch' is a new Page Insights feature and will allow you to create a list of businesses you're interested in and track their performance. You'll get to see other companies 'page likes' and how much engagement their content is driving. Useful tool.
It's becoming clearer and clearer that the focus is relentlessly on content. Google has already made this clear and now Facebook has too.
Interesting and engaging content is the way to win on Facebook.
This could make it difficult for businesses who don't have the time to invest in generating this type of content. However, it is this type of content that drives engagement, website traffic and new business.
Let us know what you think of the new page layout in our comments section below.
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Arts, Culture & Community with the Coast Collective
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The Art Space Program provides the opportunity to bring art out in the community with a frequently changing displays of original artwork at larger venues by local artists. Pieces are offered for sale and sales are handled by Coast Collective. There is no charge for businesses to participate in this program. They only need to sign a simple contract and provide access at mutually agreeable times so the art displayed can be changed every 2 months.
If you are interested in participating either as an artist providing works or as business providing space for this program,please contact us at 250-391-5522 or e-mail us at email@example.com.
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The Coast Collective Arts Centre is a cultural enterprise
of the Society for Arts on the South Island (SASI)
The Coast Collective Arts Centre is a dynamic, inspiring centre promoting art and culture, connecting community members of all ages through creative expression and explorations. Gallery exhibits bring the works of talented emerging and established Canadian artists and artisans to the public at an accessible location. An Artisan Gift Shop showcases juried handmade works that celebrate the artistry and craftsmanship of Southern Vancouver Island. Exceptional, innovative, international-calibre instructors encourage the pursuit of excellence and fun for artists of all ages and abilities.
A special thank you to our Sponsors
Copyright Society for Arts on the South Island (SASI) dba Coast Collective © 2017 Colwood BC
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EITACIES INC announces it's services compliance, making it one of the best IT Companies in the world to achieve this level of certification
EITACIES, a leading IT service provider, announced it will achieve another best Service Provider compliance following recent changes to the EITACIES Services focused on helping customers successfully leverage their investment to drive business and address key market trends shaping the industry. Our proven expertise has provided us immense experience to help organizations build the technology solutions that will enable them to reach their goals of improving energy efficiency and increasing service reliability to their customers
EITACIES provides the necessary talent, expertise, products and resources to make our client's information systems and technology work effectively. Each member of the EITACIES team possesses the ingenuity, drive and talent to make a positive difference to the client's business
By using EITACIES Engineering Talent and solution accelerators, our clients are assured that the services offered to their individual customers are already fully accomplished to the very highest and latest standards - this eliminates overhead cost and fees that companies would experience if tasked with meeting these standards separately. "As a result, the increase in demand for our services provides the added benefit of cost savings while also freeing up time for our clients and their customers."
EITACIES Inc, established since 2008 with operations in the United States and Asia, with professional services in Information Technology is a recognized leader in delivering proven business and IT strategies and solutions to Global 2000 companies across many industries. With a balanced view of strategy, people, process and technology, we work with companies to understand their unique business needs, and to develop and implement practical business strategies and technology solutions. From business strategy development through application deployment, our consultants are committed to helping clients quickly realize measurable business value and achieve sustainable ROI.
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Helps to select qualified candidates to fill required positions in the leadership of the organization. Organizes and manages the call for candidate nominations. This important committee will aid in developing the future direction of the association through its leadership.
Education and advocacy to improve ethics, standards, and practices in paleontology
Elections Committee
1. Key Responsibilities
a. Seek input from the Board on the needs for each election cycle.
b. Establish a timeline for the election cycle and determine a voting platform that
best fits the needs of the Association.
c. Solicit nominations, vet candidates, and inform nominees of their placement on
the ballot.
d. Report the election results once they have been tabulated to the Board.
2. Expected time commitment
a. Committee members will spend an average of 1-2 hours per month, with an
increase up to 4 hours per month during the election season.
b. The committee shall maintain a calendar of events associated with Annual
Election of the Board.
3. Specific qualities/skills/attributes beneficial for membership in committee
a. Committee members should be prepared for the time commitment associated
with the annual election.
b. Good communication, writing, and editing skills.
4. Available support for committee: funding, board support, existing materials
a. Collaboration with Membership Secretary for up to date membership
b. Collaboration with Board Treasurer for funding.
5. Accountability to the board
a. The committee shall provide the Board regular updates not less than once per
month on the status of annual election that will include timelines, costs, and
Committee Chair
Deb Wagner
University of Texas at Austin


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Alright, now we're getting serious. The book description is where you need to put in some serious thought. That's not to say that you don't need to think about what you put in the "Publisher" field, but I don't think too many people on Amazon buy or don't buy books based solely on who the publisher is. The same can't be said for the description. A lot of people buy or don't buy books based on that.
So what makes a good description? Well, first we must appease the Amazon gods, so let's talk about what should not go in the description. According to Amazon, that includes the following:
• Pornographic, obscene, or offensive content.
• Phone numbers, physical mail addresses, e-mail addresses, or website URLs.
• Availability, price, alternative ordering information (such as links to other websites for placing orders)
• Reviews, quotes or testimonials.
• Solicitations for customer reviews.
• Advertisements, watermarks on images or videos, or promotional material.
• Time-sensitive information (e.g., dates of promotional tours, seminars, lectures, etc.).
Having said that, I do routinely see website URLs in book descriptions. If you want to add one and make sure yours doesn't get caught, I'd send readers to "mywebsite dot com" instead of "mywebsite.com." I don't know if Amazon has software that checks descriptions and denies any that include a www. or a .com (I doubt it, actually), but I think that would be a good way to play it semi-safe.
I also very, very often see reviews, quotes, and testimonials in book descriptions. I don't think Amazon even tries to enforce this one. In fact, I just looked at the #1 bestseller on Amazon (currently The Fault in Our Stars), and look what I see:
I don't know if you'd categorize that as a quote or a review, but either way, it technically shouldn't be allowed.
But still, if Amazon ever does decide to go after books with reviews, quotes, or testimonials in their book descriptions, it would be great to sleep soundly knowing that your book descriptions contain nothing of the stort.
OK. We've not done what Amazon has asked us not to do. We're good there. Now what? What makes for a good description? This is a huge topic, and it varies from fiction to nonfiction and genre to genre. What it really comes down to is making a potential reader want to buy the book. So how do you do that?
Go to Amazon and look at the bestselling books in your genre. Read their descriptions. What is it about them that would make someone want to click the buy button? While it's true that an amazing and popular book can have a lousy description (and vice versa), good books usually have good descriptions. Have you ever been swayed to buy a book after reading its description? What was it that got to you? What information do you look for when you read a book's description?
There are things that I look for in a book description when it comes to an informational nonfiction book as opposed to an naarrative nonfiction book. (Something like The 7 Habits of Highly Effective People is informational; Unbroken and Wild are narratives). Some of the things I look for in these informational books include:
- Why should I listen to the author? In other words, what credentials or experience does the author have?
- Will this book give me the information or experience I'm looking for? If it's a how-to book for example, will it convey the information I'm looking for? If it's something like a memoir or biography, will it entertain me and/or give me knowledge about the subject?
- What value will I derive from this book?
- What can I expect from this book?
As for fiction or narrative nonfiction, what you really want to do is hook the reader. I don't read much fiction, but every one in a while, I'll read a fiction book's description and become hooked. The last one to do this was a book called 3:00 a.m. by Nick Pirog. The description is short and sweet, and it is formatted simply. This is the whole thing:
Henry Bins has Henry Bins.
A sleeping disorder, named after him.
He is awake for one hour a day.
He wakes up at 3 a.m. then falls asleep at 4 a.m.
Life is simple.
Until he hears the woman scream.
And sees the man leave the house across the street.
But not just any man.
The President of the United States.
Isn't that great? How could you not want to read the book after that? Here's another good description that left me unable to resist buying the book:
Mark Jones is a henchman for hire. He guards bunkers, patrols perimeters and stands around in a boiler suit waiting to get knocked out by Ninjas. This is his job.
He's worked for some of the most notorious super villains the world has ever known – Doctor Thalassocrat, Victor Soliman, Polonius Crump; Mark was with each of them when they met their makers at the hands of British Secret Service super-spy, Jack Tempest and lived to tell the tale – if not pay the bills.
Still for every hour under gunfire there are weeks if not months of sitting around on monorails so Jones starts a book club with his fellow henchmen to help pass the time.
It was only meant to be a bit of fun.
It was never meant to save the world.
That's the description for The Henchmen's Book Club. I guess I'm a sucker for outlandish plots.
The goal here is to hook your potential readers. Walk them through a synopsis of the story (or just part of it) and then leave them with a cliffhanger. Leave them wanting more. Leave them with the desire to find out what comes next. Leave them with no other option but to buy your book. Include enough details (settling, plot, characters, etc.) to whet the appetite.
Here are some other things you could put in the description:
- Benefits of reading the book
- The tone of the book
- The tone of the writing in the book (not the same as the tone of the book)
- An excerpt from the book (i.e., a writing sample)
- Quotes from reviewers or well-known people in your niche or industry
- What readers can expect from the book (e.g., how many words or chapters, the table of contents, what the reader's end result or state will be, etc.)
- Your background or experience
- Other books you've written (especially ones in the same series)
Whether or how much you talk about the above things will depend on the type of book you've got (and in the case of some of them, how willing you are to bend Amazon's official rules a bit). No one will care much about your background as an IT consultant if your book is a cozy mystery novel set in the Florida Everglades. But if your book is a medical thriller, stating that you're a heart surgeon (if it's true) will be a point in your favor. When I wrote my book about rock climbing tips, you better believe I mentioned my extensive rock climbing experience. The fact that I've been climbing for nearly two decades and have established a ton of new climbs is a selling point that not all authors of similar books will have.
One thing I've seen authors do is to fill the description space up with nothing but quotes that praise the book. I don't know about you, but this is supremely annoying to me. If I wanted to know what other people had to say about the book, I'd be looking at the reviews, not the description.
Keep in mind that your book description doesn't have to be long. A couple sentences can be enough to convince the reader to buy if they are the right sentences.
Fancier book descriptions
It is possible to make your book descriptions "fancy" by having various font sizes, bolded and italicized text, and so on. This is done with html, but only certain html tags are allowed. Below complete list of 18 supported tags, straight from the horse's (Amazon's) mouth. Unless tagged with an asterisk (*), all tags need to be closed as well.
|HTML Tag
|Formats enclosed text as bold.
|*Creates a line break.
|Emphasizes the enclosed text; generally formatted as italic.
|Determines the appearance of the enclosed text.
|
 to

|Formats enclosed text as a section heading:
 (largest) through
 (smallest).
|*Creates a horizontal "rule" or line. Often used to divide sections of text.
|Formats enclosed text as italic.
|Identifies an item in an ordered (numbered) or unordered (bulleted) list.
|Creates a numbered list from enclosed items, each of which is identified by a
 tag.
|Defines a paragraph of text with the first line indented; creates a line break at the end of the enclosed text.
|Defines preformatted text.
|Formats text as strikethrough. See also, .
|Formats text as strikethrough. See also, <s>.
|Formats enclosed text as bold. See also, .
|Formats enclosed text as subscript: reduces the font size and drops it below the baseline.
|Formats enclosed text as superscript: reduces the font size and places it above the baseline.
|Formats enclosed text as underlined.
|Creates a bulleted list from enclosed items, each of which is identified by a
 tag.
In addition to those tags, I've found that you can use the  tag to center align headlines.
So how do you use these tags? Well, let's say you want a sentence in your description to be bold. You would use the following in your description:
This is the sentence I want to be bold.
Make sense? (The  part is what I meant when I said that most of the tags need to be closed.)
It's all well and good to see that list of html tags, but what do they actually look like when used in a book description? I, too, wanted a more visual look at what each tag does, so I ended up using all of the tags in a dummy book description, publishing it, and then seeing what each tag turned out to be. Below is the result. Click the image for the full-size version.
Here is the plain text that I used in the book description to get that formatting. (That link is to a .txt file.)
In my opinion, you can ignore the , ,
, and  tags. Don't worry about those. They are either redundant or don't really do anything.
Further reading
If you want to read more about writing fiction book descriptions, check out the following:
- The 11 Ingredients of a Sizzling Book Description
- Making Digital Books: Writing Great Descriptions for Your Ebooks – This blog post also includes several links to other good articles that are worth reading.
Previous: Book series, edition number, and publisher
Next: Book contributors and language


text: Contents[show] Catchphrase Edit "Give a wave of applause please!" Info Edit Species: Wave warrior Gender: Male Element: Water Role: Skylander World: Skylands Appearance Edit Tsunami is a living tidal wave with a water sword and shield. Background Edit Personality Often greedy, but is a help. Story Retrieved from "http://skylanders-fan.wikia.com/wiki/Tsunami%27s_Database?oldid=21372" Ad blocker interference detected! Wikia is a free-to-use site that makes money from advertising. We have a modified experience for viewers using ad blockers Wikia is not accessible if you've made further modifications. Remove the custom ad blocker rule(s) and the page will load as expected. Categories: Add category Cancel Save


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15 Of The Most Brilliant Moments From "The West Wing"
Bartlet for America.
These Celebrities Have A Hilarious Message For The Class Of 2017
"Never give up, unless it's hard."
Rob Lowe Addressed Those Rumors About His Crazy Demands For A Personal Assistant
He's funny and a good sport...you just might want that job after all.
Watch Rob Lowe Help Two Disgruntled Roommates Solve One Big Problem
"He smells like the last day of Burning Man."
9 Celebrity #TBT Photos You Need To See This Week
Sarah Michelle Gellar paying homage to Cruel Intentions kicks off this week's #ThrowbackThursday.
There Was An Amazing "West Wing" Reunion On "The Grinder" And Now Everything Is Great
Good to see you, Sam and Toby.
People Are Upset With Rob Lowe After He Tweeted About The Paris Attacks
"Oh, NOW France closes its borders."
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Rob Lowe, Ageless Wizard.
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Can you get through this post without saying "cute"?
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text: Low carbon technologies in the country are about to get a significant boost as around £56 million in investment is going to be put into the industry. Around £27 million of this is going to come from the Office for Low Emission Vehicles. This funding from the public sector is going to be complimented by nearly £30 million from the private sector and it is


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MANCHESTER, NH – Democratic candidate for Governor, Maggie Hassan today launched her campaign's North Country Steering Committee with over 30 key volunteers and activists from the region.
The group will be chaired by former State Representative Tom Buco of Conway and veteran and candidate for State Senate, Jeff Ballard of Brookfield.
"I am honored by our great support in the North Country," said Hassan. "We are in strong shape with Tom Buco and Jeff Ballard helping lead the way. I'm looking forward to working with them and our entire committee all the way to November and beyond."
"I am proud to support Senator Maggie Hassan to be the next Governor of New Hampshire," said former State Representative Tom Buco of Conway. "She will govern, as Governor John Lynch has, by putting the people of New Hampshire first, above politics. Maggie will work with both Republicans and Democrats to keep New Hampshire the safest state to raise children and the best state to conduct business. She will foster positive business conditions by keeping taxes under control and promoting an educated workforce."
"My decision to endorse Maggie was an easy one," said Jeff Ballard, candidate for State Senate from Brookfield. "At the end of the Governor Lynch's term, we need a leader who will unite New Hampshire and continue a path of bi-partisan progress. With Maggie I know we will have a leader with the ability to reach across the aisle when both sides are willing to work together, but also with the conviction to not compromise her beliefs."
Maggie Hassan for Governor North Country Steering Committee Co-Chairs
Jeff Ballard, Brookfield, veteran, candidate for State Senate
Tom Buco, Conway, former State Representative
North Country Public Supporters
Ted Adriance, Sandwich, small business owner
Stephanie Ballard, Brookfield, small business owner
Mary Breasted Smyth, Tamworth, Democratic Party leader
Brian Bresnahan, Groveton, Democratic Party leader
George Cleveland, Tamworth, Democratic Party leader
Don Ekberg, Conway, former County Democratic Chair
Laurel Ekberg, Conway, town Democratic Vice Chair
Kelly DeFeo, Conway, former County Democratic Chair
Carol DeLaurier, Brookfield, Democratic Party leader
Frank Frazier, Brookfield, Democratic Party leader
Pam Frazier, Brookfield, Democratic Party leader
Peter Goodwin, Wolfeboro, Democratic Party leader
Susan Goodwin, Wolfeboro, Democratic Party leader
Jaye Hays, Ossipee, Town Democratic Chair
Rep. Bill Hatch, Gorham, State Representative
Mark Hounsell, Conway, former State Senator
Bud Martin, Sandwich, Selectman and former Judge
Rep. Evalyn Merrick, Lancaster, State Representative
Porter Miller, Orford, Democratic Party Leader
David Mitchell, Whitefield, Coos County Democrats Chair
Duncan Porter-Zuckerman, Sandwich, Democratic Party leader
Eve Porter-Zuckerman, Sandwich, Democratic Party leader
Rebecca P. Sinkler, Sandwich, Democratic Party leader
David D. Sinkler, Sandwich, Democratic Party leader
Dorothy Solomon, Albany, County Commissioner, former County Democratic Chair
Dawn Steele, Franconia, Democratic Party leader
Rep. Robert Theberge, Berlin, State Representative
Paul Turner, Sanbornville, Democratic Party leader
Jeff Woodburn, Twin Mountain, former New Hampshire Democratic Party Chairman


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The Black Dahlia Murder
On October 6th, The Black Dahlia Murder will release their eighth full-length, 'Nightbringers', via Metal Blade Records. For a first preview of the record, a video for the title track can be viewed at metalblade.com/tbdmRead More
On September 15th, Metal Blade Records will release Whitechapel's 'The Somatic Defilement' for the first time ever on vinyl! Re-mastered for vinyl, this special re-issue will be available in following versionsRead More
Act of Defiance
Act of Defiance to release new full-length album, 'Old Scars, New Wounds', on September 29th; video for new single, 'M.I.A.', now onlineRead More
New Releases
Upcoming Releases
Latest News
KETZER announces new album "Starless" for January, 29th of 2016!
- 04/11/15 – Landing page with first single, album art and pre-order...Read More
REVOCATION premieres "Alliance and Tyranny" live video via DecibelMagazine.com
- 03/11/15 – New lyric video for "The Fix" out now! On...Read More
VISIGOTH launches live video for "Iron Brotherhood" from last month's "Frost and Fire Festival"!
- 03/11/15 – Last month, Salt Lake City's VISIGOTH delivered a...Read More
TWITCHING TONGUES releases new video for "Insincerely Yours"
- 30/10/15 – New album, 'Disharmony', out now! Southern...Read More
KING DIAMOND: new video interview on Vice
- 29/10/15 – Upcoming shows in Detroit and Philadelphia to be filmed...Read More
RAM: 'Svbversvm' full-length from Swedish heavy metal loyalists streaming in full at Noisey
- 28/10/15 – Record to see worldwide release this Friday via Metal...Read More
EXUMER announces more European tour dates and support acts for "Road Rage 2016″!
- 28/10/15 – German thrash masters EXUMER will enter the studio in...Read More
TWITCHING TONGUES streams new album, "Disharmony", via Lambgoat.com!
- 26/10/15 – This Friday (October 30th), southern California's...Read More


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Words that end in anquan
Found 1 words that end in anquan. Browse our Scrabble Word Finder, Words With Friends cheat dictionary, and WordHub word solver to find words that end with anquan. Or use our Unscramble word solver to find your best possible play! Related: Words containing anquan
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1149 West Lancaster Ave Bryn Mawr PA 19010
Focused on providing cutting-edge technology education in the Philly area.
45 Haverford Rd Wynnewood PA 19096
Montgomery County, PA, United States
Camps. After-school programs. School's out camps.
40 North 2nd Street, Philadelphia, PA 19106, United States
Arden Theatre Company is dedicated to bringing to life great stories by great storytellers – on t...
550 Foundry Rd, East Norriton, PA 19403, United States
Weekly open play & family night sessions. Weekday and weekend parties by reservation only. Fi...
874 Welsh Road, Maple Glen, PA, United States
Competitive Edge Martial Arts offers highly individualized and exciting martial arts programs for...
11 Lancaster Avenue, Malvern, PA, United States
Grand Slam U.S.A. is over 30,000 square feet of indoor family fun. We have activities and sports ...
4251 State Road Devault PA 19432
Parties, Field Trips, Scout Activities
1950 Spring Mill Road, Gladwyne, Lower Merion Township, PA
Connecting children to the natural world is the heart of Riverbend's mission. We believe no...
8480 Hagy's Mill Road, Philadelphia, PA 19128
The Schuylkill Center inspires meaningful connections between people and nature. We use our for...
222 N 20th St Philadelphia PA 19103
(215) 448-1200(215) 448-1200
35 N Narberth Ave, Narberth, PA, United States
The Handwork Studio is a kids' needle arts, machine sewing and fashion camp. Our purpose is...
20 School Lane, Rose Valley, PA, United States
The School in Rose Valley is a progressive school for children in preschool through sixth grade. ...
780 Miles Road, West Chester, PA, United States
484-678-1602 and 484-319-8825484-678-1602 and 484-319-8825
Think Like a Scientist! llc began as a dream. Coleen and Jodi began teaching together at a local ...
431 West Valley Forge Road, King of Prussia, PA, United States
Are your kids ready to play? Discover how our unique Training Methodology can put elite in their ...
1416 Berwyn Paoli Rd Berwyn PA 19312
(610) 647-9622(610) 647-9622
Showing 16 results


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Do I get any tax benefits from leave travel allowance (LTA)?
The exemption is allowed only with respect to the fare. Expenses incurred towards boarding and lodging or on conveyance to and from the railway station/airport do not qualify for exemption.
How often can I claim this exemption?
You can claim LTA exemption twice in a block of four calendar years. The current block is 2006-09.
What if I am not able to claim exemption in a particular block?
One journey can be carried forward and claimed in the first calendar year of the succeeding block. Thereafter, you can claim the two remaining journeys of that block.
Who can come along?
Travel exemption is available only for your spouse, up to two children, dependant parents, brothers and sisters.
How is the exemption amount calculated?
The travel concession is exempt to the extent of the amount spent on travel or the following specified limits, whichever is less:
• If the mode of transport is air: economy airfare on a national carrier on the shortest route.
• Any mode other than air: If the destination is connected by rail, then it would be first-AC rail fare on the shortest route.
If it is not connected by rail, then it is first-class or deluxe fare where a recognized public transport system exists.
For places where a recognized public transport system does not exist, it would be first-AC rail fare for an equivalent distance.
Do I need to submit travel bills to my employer to claim LTA?
According to a 21 January Supreme Court judgement, employers are under no statutory obligation to collect travel bills from their employees to allow LTA exemption.
What if I failed to claim LTA and my employer had deducted tax on the LTA amount?
You can claim it in your income tax returns and you'll get a refund for the tax deducted.
If I receive a gift, is it taxable?
Any sum of money which exceeds Rs50,000 and is received as a gift (i.e., without consideration) by an individual or a Hindu undivided family is taxable.
Does this mean nothing will be taxable if the gift amount is up to Rs50,000?
Yes. Gifts up to Rs50,000 are not taxable. Also, this is applicable to aggregate gifts received by an individual from various sources. Let's take an example. Ganesh receives a gift of Rs25,000 from Amit and another Rs26,000 from Mohan. Since the aggregate value of the gift received exceeds Rs50,000, the entire amount of Rs51,000 will be taxable.
Are there any exceptions?
It does not apply to gifts received from any relative, during the individual's marriage, under a will or by way of inheritance in contemplation of death of the payer, any local authority, trust or university.
What about the taxability of gifts in kind?
Gifts in kind or of immovable property are not covered and are exempt without limit. A gift in kind does not include monetary instruments such as national savings certificates (NSCs), fixed deposits (FDs), cheques, etc. Those gifts are taxable.
What are the tax benefits for a gift to a spouse?
If you make a gift in kind or cash to your spouse, it is not taxable in their hands. However, any income generated by the gift in kind or cash shall be treated as your income.
What if I give a gift to my fiancé?
The good news is that if you make a gift in kind to your fiancé, then there is no tax implication. However, if your gift amount exceeds Rs50,000, then the entire amount will be added to your fiancé's income.
If I transfer my assets to my spouse or fiancé, does that create a tax issue?
If you transfer an asset—for example, a house—to your spouse, any income accruing from this asset shall be clubbed with your income and taxed in your hands.
But if you transfer the same property to your fiancé, and are to get married soon after the transfer, then even after your marriage, any income accruing on this asset will not be taxed as your income. This is because the marital relationship did not exist at the time of the asset transfer.
What are the tax implications of giving a gift to my parents?
Any gift in kind or cash is tax free in the hands of your parents and does not lead to any tax liability for you either.
Is there anything else to be taken care of while making a gift?
While receiving a gift, it is always in the interest of the donee to get a gift deed signed by the donor. This might be required to justify gift receipts in the event of future issues raised by the tax authorities.
House rent allowance (HRA) is given by an employer to an employee to meet expenses for the rent of accommodation. For HRA, it is important that you don't own the property and that you are paying rent.
How is HRA calculated?
Your HRA is the least of the following three limits:
1. Rent paid in excess of 10% of salary.
2. 40% of salary (50% if the property is located in Delhi, Mumbai, Kolkata,and Chennai).
3. Actual HRA allowance received.
Salary for the purposes of this calculation is the sum of the following:
• Basic salary;
• Dearness allowance, if being paid by employer;
• Commission, if given as a fixed percentage of the turnover achieved by the employee.
Can I claim HRA exemption if I am staying in property belonging to my parents or my spouse?
If you are living in a house owned by your parents or spouse and you are paying rent to them, then you can certainly claim HRA. However, the rental income they earn must be shown by them as income in their tax return to avoid any problems.
Can I claim HRA exemption along with other home loan tax benefits?
Yes, it is possible. Home loan repayment tax benefits are available as a deduction for repayment of home loan. If your employment requires you to be in a different location or city as a result of which you cannot occupy your own house and end up living in rented accommodation, you can certainly claim both benefits.
If you have held two jobs during the financial year, how do you know if the right amount of TDS is being deducted? If you have taken the wrong amount of deductions or taken the deductions twice, you might end up paying extra interest.
Should I disclose TDS deducted by my old employer to my new employer?
You should disclose it to avoid problems. When you file your tax return, your income from both employers will be clubbed together. The deductions and tax-slab benefits will be allowed only at one place. If you have taken these benefits twice, you will have saved on paying taxes. Additionally, there can be a large amount of interest added to your tax liability for late payment, as this tax ought to have been deducted by the employer at the time of giving your salary.
What should I disclose to my new employer?
• Salary received from the previous employer;
• Tax deducted (TDS) by the previous employer;
• Tax savings and investments eligible for deduction already declared with the previous employer.
Every year, inflation eats away at our disposable income, which ultimately results in a much higher cost of living. This issue is even more critical for retired people whose incomes cannot keep pace with inflation. However, if you actively manage your investments, you can protect yourself from the effects of inflation. You can invest in instruments that offer you long-term capital appreciation that is higher than the inflation rate. For instance, you could look at equities or equity mutual funds as opposed to fixed deposits.
As mentioned above (see GIFTS AND TAXES), any gift in cash or kind to your parents is tax-exempt. In fact, if you gift them a health insurance plan, you can get a tax benefit for yourself as well. As your parents age, their health care needs will increase. After 60, it gets tougher to get health insurance. Make sure you get them health coverage sooner than later, and also save up to Rs6,600 in taxes this year.
Under section 80D of the tax code, you can get up to Rs15,000 tax deduction towards the premium paid for health insurance for your parents, whether they are dependent on you or not. Additionally, if your parents are senior citizens, then you can get a further Rs5,000 deduction.
For a self-occupied property, interest deduction in your income-tax return on a home loan is capped at Rs1.5 lakh. But if you let out the house, the entire amount paid on the loan can be deducted in full. Whatever interest you've paid in the current financial year, plus one-fifth of the interest paid during the construction period, will be allowed in full, without any cap of Rs1.5 lakh. If you own multiple properties and all of them are occupied for residential purposes, then you can claim any one as self-occupied, and the others shall be deemed let out.
Are you aware that credit card debt is the most expensive form of debt? A typical credit card charges you an annualized percentage rate of approximately 30-45% on any unpaid balance on your card after the due date. Compare this with typical personal loans that would cost less than 20%. Additionally, there will be hefty late payment charges that could be around 5% of the outstanding amount. If you withdraw money from an ATM using your credit card, there will be transaction fees of around 2.5% of the withdrawal amount, subject to a minimum fee of up to Rs300, and there will be finance charges as well. The bottom line: Avoid credit card debt as much as you can.
Content provided by iTrust Financial Advisors
Write to us at email@example.com


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ISS Singapore's Reviews > Darius Bell and the Glitter Pool
Darius Bell and the Glitter Pool (Darius Bell, #1)
by Odo Hirsch
by Odo Hirsch
ISS Singapore's review
bookshelves: elementary-middle-school
Jan 12, 2011
bookshelves: elementary-middle-school
The Bell family's ancestors were showered with honours, gifts and grants of land. In exchange, they have bestowed a Gift, once every 25 years, on the town. The Gifts have ranged from a statue to a bell tower with stained-glass windows, but now it's Darius's father's turn - and there is no money for an impressive gift. It looks as though a wheelbarrow full of vegetables is the best they can do. Darius is determined to maintain family honour, and when an earthquake reveals a glorious cave, with the most beautiful minerals lining the walls, he thinks he's found the answer...
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Tuesday, June 1, 2010
Spice Cupcakes
2 1/2 cups all-purpose flour
2 teaspoons baking powder
1 teaspoon ground cinnamon
4 pinches ground nutmeg
4 pinches salt
12 tablespoons butter
1 1/3 cups sugar
4 eggs
1 teaspoon vanilla extract
1/2 cup milk
Preheat oven to 350 degrees F (175 degrees C). Line 12 muffin cups with paper muffin liners.
Combine ingredients until light and fluffy with an electric mixer. Pour the batter into the prepared muffin cups.
Bake in the preheated oven until golden and the tops spring back when lightly pressed, 15 to 20 minutes.
2 (8 ounce) packages cream cheese, softened
1/2 cup butter, softened
2 cups sifted confectioners' sugar
1 teaspoon vanilla extract
This morning I made these spice cupcakes, adapted from a recipe I found here. They turned out more like muffins for me, and they were a little dry (next time I may use a little less flour), but after adding this delicious cream cheese frosting, they were much more delicious. I'm not sure that I'll make the cupcakes again with this recipe--it just wasn't my favorite. However, I've got a lot of extra frosting that I can't wait to use, and I'll definitely make that again. Not only was it super easy, but it was also incredibly tasty. Not a great recipe if you're looking for super sweet icing, but perfect to cut into sweet or spiced cakes. Happy June! :)
Posted by Kelly at 1:04 PM
Labels: Cream Cheese Frosting, cupcakes
Subscribe to: Post Comments (Atom)


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- Looking for parents of James Henry Jackson born 1896 died 1936 Raleigh, NC
Married Della Gooch Lived in Raleigh, NC
Name of parents shown on aboves' marriage license is Father - James Jackson
Mother - Jennie ( maiden name could have been Hamilton?)
If this is James Henrys mother, she died when he was young and his father
remarried and had 2 sons Claude and Jack?
Anything will be appreciated
[Non-text portions of this message have been removed]
- Looking for info on a Lena Jackson. Husband unknown.
Children: James born 1848, Elizabeth Ann and Francis born 1853 Twins
Also, looking for a Polly Jackson. who was blind. Probably born mid to late
[Non-text portions of this message have been removed]
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Natural hair blogger @chronicurls used T-Roots Butter Curls defining creme and 5-in-1 Oil along with flexirods to create this cute look for a night out on the town.
Natural hair blogger @jolieluvlee used T-Roots Butter Curls defining creme and 5-in-1 Oil for a super hydrated and defined twist out. Listen to her product review and what she thinks of her results. (Starts at 5:58)
Beauty influencer and natural hair guru Janell Stewart (@blakizbeautyful) used T-Roots Butter Curls to create this super easy updo.
Beauty blogger @dominiquesvanitycorner shows us a quick flexirod style on stretched natural hair using T-Roots Butter Curls
Natural hair nomad @khalilahkjcurls shows us how to create mini faux bangs using flexirods and T-Roots Butter Curls
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Primary: Love and friendship is in the air! Let's celebrate! Every Valentine's Day we host a party for students to create crafts, play Valentine themed games and eat yummy treats at school. We invite parents to join in the fun too! Elementary: The elementary years mark the development of social skills. Class parties are the perfect time to practice and develop these skills. From start to finish students plan the event and get to enjoy the festivities. Montessori views class parties as…Find out more »
Teachers will set these conferences up individually with Pre-K & K families. These conferences will be scheduled in before or after school.Find out more »
Fathers deserve to be celebrated! We invite Dads to join their child for breakfast at Dads-N-Donuts. Students always have a special gift for their parents at these events.Find out more »
Every spring our students become world travelers as we journey around the globe in preparation for our International Festival. This is a unique event where each student chooses a county to learn about and represent. During the month of April, they learn about the geography, culture, and language of their country. Students learn to say hello and goodbye in their country's native language and a fact about their chosen country. At our Festival, each child will be handed a microphone…Find out more »
Mothers deserve to be celebrated! We invite Moms to join their child for breakfast at Moms-N-Muffins. Students always have a special gift for their parents at these events.Find out more »


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A departmental head at Sudan's Ministry of Culture issued a letter dated 29 January to the Sudanese Writers Union revoking its licence for unidentified violations of procedure. Effectively a ban, the decision was communicated to the union in a Kafkaesque statement of three lines devoid of a specific accusation or a reference clause of regulations, the type of statement that is the naked language of power.
In a sense, this second ban of the Sudanese Writers Union brackets a history, the first ban was in 1989 when President Bashir and his fellow officers assumed power. Like other independent trade unions and professional associations, the union was prohibited, its property confiscated and its headquarters at the mugran (confluence) of the Niles in Khartoum handed over to the General Union of Sudanese Students, a mobilisation agency of the new government.
Disbanded, the union remained a network of relationships and a staple of documents in the office of its secretary general, the lawyer and poet Kamal al-Gizouli, for sixteen years. Only after the signing of the 2005 Comprehensive Peace Agreement between the government of Sudan and the Sudan People's Liberation Army/Movement (SPLA/M) was it feasible to reconstitute the union and regain its legal status, an effort that I had the opportunity to contribute to in 2006. Kamal chose the term 'second birth' to celebrate the undertaking, and it certainly was.
Kamal invested a chunk of his poetic soul in the Writers Union but the project expanded beyond his old network and soon grew out of his mantle contrary to the expectations of many critics. The Writers Union is an association of largely urbanite and Khartoumite intellectuals and has thus been famously criticized by 'New Sudan' advocates as a union of' Arab Muslim' Sudanese writers. Considering the voracious appetite for democratic procedure at the time of its 'rebirth', elections for the leadership of the union were hotly contested, its mandate subject to excruciating scrutiny and its activities closely monitored by detractors and sympathisers alike.
For many of its members, the union was a replacement political party. It was expected to issue position statements on current affairs and mobilise for political struggle. The union, however, continued to operate on known ground. It organised and hosted cultural events peaking in an annual themed conference and reissued its irregular journal. Over time, it developed a certain routine, established new headquarters after a period of nomadic operation and settled to a limited bureaucracy and an elected executive. In the process, it entered into a 'partnership' with business and its events featured advertisements of the telecommunications giant Zain (Sudan) for a year or so.
The radical bend the Writers Union had in its beginnings, when it was densely inhabited by leftist intellectuals, has been greatly 'straightened' in recent years, whether in consequence of the general fatigue of the left or the implications of Sudan's neo-liberal transformation. Today, it is largely an association of liberally minded intellectuals, but that is already too much for the caretakers of power. The explanation, I presume, is that it continues to cherish a threatening principle. It is a free association accessible to all willing Sudanese writers without religious, ethnic, sectarian or gender restriction, and beyond that it successfully funds itself without need for government largesse and it organises!
The threat of this simple principle continues to enrage the security authorities each time they are reminded of the existence of the Communist Party. Tijani Tayeb, the late veteran leader of the party, probably had this principle in mind in a brief speech he made to a celebration in Cairo exile back in 1996 marking the fiftieth anniversary of the Communist Party. "The early communists stormed an unknown to them and to the Sudanese society by establishing a party of a new kind without prior experience," he stated. The authorities might ban the Sudanese Writers Union but this principle, a living legacy of the Communist Party which it once vigorously transplanted into the trade union movement, it can never ban. Hence, long live the struggle of the Sudanese Writers Union.


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Baily Garner were appointed Architect and Employer's Agent to deliver a new development of 40 affordable and shared ownership homes at Cranwell Road, replacing 44 existing substandard flats built in the 1970s. With additional services provided by our Environmental Group for this £5 million scheme, the new energy efficient homes include18 affordable family houses with 2, 3 or 4 bedrooms, private front and back gardens and off road parking, together with 22 flats, 11 for shared ownership, with 1 or 2 bedrooms, communal areas to the front and rear and a 22 space shared parking area. A two bed wheelchair house, designed to achieve full Habinteg standards, was also included in the scheme.
Completed in 2014, new homes were designed to meet HCA design requirements and to achieve Code for Sustainable Homes Level 3, incorporating very high levels of insulation whilst providing 10% of renewables for energy, particularly through the use of solar panels to south-east facing roofs. The modern new development has a distinct character, inspired by the villas in the immediate vicinity and designed to link with the size and scale of the existing terraces along Cranwell and Bretland Road