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The time now is 11:45 PM. -- Mobile_Default -- TSF - v2.0 -- TSF - v1.0 Contact Us - Tech Support Forum - Site Map - Community Rules - Terms of right click Volume taskbar icon select Playback devices disable the main pc speakers It will immediately route all sounds to the USB headset without having to restart any applications. USB connector: If the device uses a USB connector, disconnect and then reconnect the USB connector to the computer. That's what drivers are for. http://admitcore.net/not-working/usb-headphones-not-working.html
Figure : Update Driver Software option in Device Manager Click Search automatically for updated driver software and wait for Windows to update the driver software. Looking for a movie of about futuristic city and alien society more hot questions question feed about us tour help blog chat data legal privacy policy work here advertising info mobile Sign in to add this to Watch Later Add to Loading playlists... Sign in Transcript Statistics 46,879 views 106 Like this video?
I've tried reinstalling the driver a few times too but nothing worked. About Press Copyright Creators Advertise Developers +YouTube Terms Privacy Policy & Safety Send feedback Try something new! MrJamieTECHGEEK 204,090 views 2:35 Best Gaming Headset? (PC, PS4, XBOX ONE) - Duration: 7:52.
If you want to manually move the audio, you can do so in the control panel. Usb Headphones Not Working Windows 7 Also, using an adaptor might affect the quality of the audio. GIGABYTE - Motherboard - Socket 1155 - GA-B75M-D3H (rev. 1.0) Note your bios version during bootup, as as you have a Cyberpower PC you should contact them about doing any kind I can't change my default playback device.
Figure : Windows has successfully updated your driver software If updating the driver did not resolve the issue, continue to the next section. Usb Headset Not Detected Windows 10 Choose Playback Devices. You earn reputation points by for example asking questions and answering other peoples questions. –Mogget Apr 13 '13 at 14:17 add a comment| 3 Answers 3 active oldest votes up vote Sign in to make your opinion count.
Squeaky belt issues on '95 Chevy S10 Driving through Croatia: can someone tell me where I took this photo? http://support.hp.com/gb-en/document/c04474731 I need an MS hotfix [SOLVED] Windows 10 Mic issues RAM Upgrade The circus is on the road No icon images for new user account After Processor Upgrade, no... Usb Headphones Not Working Windows 10 share|improve this answer answered Aug 28 '09 at 4:30 Steve Rowe 2,89921826 I've done this already, but after I've started a program, it uses the audio device that was Px22 Pc Setup If the device you want to use contains a small circle with an arrow pointing down, the device is disabled.
i would also check bios and make sure the audio is enabled. this contact form See your browser's documentation for specific instructions. {} Z7_3054ICK0KGTE30AQO5O3KA30U5 hp-support-head-portlet Actions ${title} Loading... Cancel all of that out, then unplug your headset and wait about 30 seconds. Visit now Z7_3054ICK0KGTE30AQO5O3KA30H4 hp-feedback-banner-portlet Actions ${title} Loading... Usb Headset Not Working Windows 8
What kind of headphones are these? Figure : Selecting the Audio tests Select Run Once and press Enter. Leave the Playback tab open and refer to the Step 2: Setting the default device section of this article. have a peek here You should be able to see your headphones there.
Is it possible to formulate the Schrödinger equation in a manner that excludes imaginary numbers? Turtle Beach Px22 Drivers Windows 10 If the computer cannot play sound from the speakers, choose one of the HP support documents below to resolve that issue: Desktop computers - No Sound from the Speakers (Windows 8) Headsets with two jack connectors are only compatible with computers that have both a headphone and microphone port.
Sign in to make your opinion count. LinusTechTips 610,875 views 12:02 Explaining USB 3.0 - Duration: 4:42. Posting your PC specs will help us to assist you quicker and effectively. 03-19-2014, 08:55 PM #11 mattman1995 Registered Member Join Date: Mar 2014 Posts: 11 OS: Windows Check This Out Try Windows Media Player.
Then click Next and follow the on-screen instructions. For headset compatibility, you might also want to check the section of this article called Headsets: Checking for computer port compatibility. This feature is not available right now. Integrity with anti-confidentiality US Election results 2016: What went wrong with prediction models?
Could someone explain what knot theory is about, exactly? The connectors are marked with symbols next them. Worth TX Posts: 1,460 OS: Windows 7 Ok then I would look to contacting Cyberpower about the issue, and also seeing if you can just replace the headset with another exact HP PCs - Resolving Headphones and Headset Problems (Windows8) Before you begin Checking the headphones or headset Updating the audio driver Using the Windows troubleshooting tool Checking the sound settings Troubleshooting
Search by Keyword or Article ID How to Follow Up on Your Warranty Replacement (Australia) How to Replace a Defective Headset in New Zealand Plantronics Manager Pro: How to Modify a scythe7 Motherboards, Bios & CPU 28 09-20-2013 08:32 AM Computer Won't Play Sound Through Headphones Hi, Recently the power cable for my speakers broke, therefore the only other device I currently Loading... One supports only sound to the headphones, and the other supports sound to the headphones and the use of a microphone.
USB headphones will require hardware drivers. What were the results? 03-19-2014, 09:21 PM #16 mattman1995 Registered Member Join Date: Mar 2014 Posts: 11 OS: Windows 7 I went through everything mentioned so far with The Properties window opens. I usually play games or im surfing the net.
What program are you using?
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COL4A1 mutations cause familial porencephaly, infantile hemiplegia, cerebral small vessel disease (CSVD), and hemorrhagic stroke. We recently described hereditary angiopathy with nephropathy, aneurysm, and muscle cramps (HANAC) syndrome in 3 families with closely localized COL4A1 mutations. The aim of this study was to describe the cerebrovascular phenotype of HANAC.
Detailed clinical data were collected in 14 affected subjects from the 3 families. MRI and magnetic resonance angiography (MRA) were performed in 9 of them. Skin biopsies were analyzed by electron microscopy in affected subjects in the 3 families.
Only 2 of 14 subjects had clinical cerebrovascular symptoms: a minor ischemic stroke at age 47 years and a small posttraumatic hemorrhage under anticoagulants at age 48 years. MRI-MRA showed cerebrovascular lesions in 8 of 9 studied subjects (mean age 39.4 years, 21–57 years), asymptomatic in 6 of them. Unique or multiple intracranial aneurysms, all on the carotid siphon, were observed in 5 patients. Seven patients had a CSVD characterized by white matter changes (7/7) affecting subcortical, periventricular, or pontine regions, dilated perivascular spaces (5/7), and lacunar infarcts (4/7). Infantile hemiplegia, major stroke, and porencephaly were not observed. Skin biopsies showed alterations of basement membranes at the dermoepidermal junction associated with expansion of extracellular matrix between smooth vascular cells in the arteriolar wall.
The cerebrovascular phenotype in hereditary angiopathy with nephropathy, aneurysm, and muscle cramps syndrome associates a cerebral small vessel disease and a large vessel disease with aneurysms of the carotid siphon. It is consistent with a lower susceptibility to hemorrhagic stroke than in familial porencephaly, suggesting an important clinical heterogeneity in the phenotypic expression of disorders related to COL4A1 mutations.
Type IV collagen is a major component of basement membranes. Type IV collagen α1 and α2 chains form the widely expressed α1α1α2(IV) heterotrimers.1–3 Mutations in the COL4A1 gene, which encodes the α1(IV) chain, have been reported in 6 families with autosomal dominant forms of porencephaly, in which a porencephalic cavity is caused by a cerebral hemorrhage that occurred during the intrauterine or neonatal period.4–9 A broad range of neurologic features have been described in families with hereditary porencephaly related to COL4A1 mutations, including infantile hemiplegia, mental retardation, and hemorrhagic strokes in childhood or in adults often triggered by head trauma. The cerebrovascular phenotype also includes a cerebral small vessel disease (CSVD) with leukoencephalopathy, lacunar infarcts, microbleeds, macrobleeds, and dilated perivascular spaces (DPS), sometimes without porencephaly. Three additional families with CSVD and COL4A1 mutations have been reported, 1 with hemorrhagic stroke and retinal arteriolar tortuosity, 1 with hemorrhagic stroke and cataract, and the other with ischemic stroke and anterior segment dysgenesis of the eye (Axenfeld-Rieger anomaly).10–13 One sporadic case with recurrent intracerebral hemorrhage was also reported.14 No manifestations suggestive of a systemic disease were observed in these patients. Consequently, COL4A1 mutations are a new cause of CSVD, in addition to lipohyalinosis secondary to hypertension, and to other hereditary conditions such as cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), retinal vasculopathy with cerebral leukodystrophy (RVCL), and amyloid angiopathy.
We have recently described an autosomal dominant syndrome in 3 unrelated French families that we named HANAC syndrome for hereditary angiopathy with nephropathy, aneurysm, and muscle cramps.15,16 HANAC syndrome is due to COL4A1 mutations affecting glycine residues that are in close proximity in exons 24 and 25 within the triple-helix domain of the protein. HANAC syndrome has a broad phenotypical spectrum with systemic as well as cerebrovascular features. The systemic phenotype includes a nephropathy with either hematuria or bilateral renal cysts, a muscular disease with cramps and/or elevated creatine phosphokinase (CPK), and retinal arterial tortuosity. Because ultrastructural examination of the kidney and the skin shows abnormal thickening, multilamination, and/or focal disruption of the basement membranes, HANAC is considered as a systemic "basalopathy." The objective of the present study is to give a detailed description of neurologic manifestations and brain imaging in the 3 recently reported families with HANAC syndrome.
A total of 14 affected members have been identified in the 3 families (A, B, and C) with HANAC syndrome (figure e-1 on the Neurology® Web site at www.neurology.org). As previously reported, genetic analysis showed COL4A1 mutations localized in exon 24 in family A (c.1493G>T) and in exon 25 in family B (c.1555G>A) and family C (c.1583G>A).16
The study received approval from the ethical regional committee on human experimentation ("Comité de Protection des Personnes-Ile de France VI number P061017–IDRCB 2007-A01441-52). Written informed consent was obtained from all patients participating in the study.
Nine of the 14 patients with COL4A1 mutations were directly interviewed and examined for neurologic evaluation: 3 affected brothers and their 3 children in family A, 2 patients in family B (the father and her daughter), and 1 patient in family C. Clinical information on the 4 deceased patients and on the affected subjects who declined to participate in this study was obtained through their relatives. The neurologic interview recorded mental retardation, infantile hemiparesis, strokes and their types, cranial traumas and their consequences, headaches, epilepsy, dementia, and sudden death. Risk factors for cerebral vascular disorders were recorded.
Clinical evaluation of systemic involvement, including renal, muscle, eye, and cardiovascular symptoms, has been reported in detail.16 All 14 patients and 3 relatives without COL4A1 mutation (B.III-2, B.II-1, and C.III-2) had fundus examination and retinal angiography.
Brain MRI was performed in 9 patients and in 1 unaffected relative (C.III-2) using a 1.5-T magnetic resonance scanner (contiguous slices of 5 mm thickness) and included T1-weighted images, T2-weighted images, fluid-attenuated inversion recovery sequences, and magnetic resonance angiography (MRA). T2 gradient-echo (T2*) weighted images were recorded in 7 patients. When MRA was inconclusive about the presence of an intracranial aneurysm (ICA), 16-row multislice CT angiography was performed. Four-axis conventional angiography was available in 1 patient.
All imaging data were analyzed by a consensus of 2 neurologists (S.A. and P.F.) and 1 neuroradiologist (B.M.). The following lesions were assessed: white matter changes (WMC) defining leukoencephalopathy, lacunar infarcts, DPS, microbleeds, macrobleeds, and porencephaly. MRI lesions were categorized by anatomic cerebral region (appendix e-1). For lobar white matter, it was specified when lesions affected the arcuate fibers and the center semiovale. WMC were rated according to the Scheltens visual scale, taking into account size, number, and anatomic distribution of the lesions17 (appendix e-1). The numbers of lacunar infarcts and microbleeds were recorded.
The size of each ICA was defined by its maximal diameter. The carotid siphon was divided according to Fisher classification into 5 segments from its beginning to its end with 3 extradural (C5 to C3) and 2 intradural (C2 and C1) segments. Other intracranial arteries abnormalities, such as dolichoectasia, were also examined.
A punch biopsy was performed in healthy skin of subjects A.III.3, A.IV.4, B.II.1, and C.II.3 (with the COL4A1 mutation) and C.III.2 (without the mutation). Electron microscopy was performed as previously described.16
None of the 14 subjects had infantile hemiparesis or mental retardation. There was no history of stroke during the neonatal period and childhood, or history of spontaneous subarachnoid or intracerebral hemorrhage or dementia in the 3 families. None of the 14 subjects had diabetes or hypertension, 1 patient had hypercholesterolemia (A.III.1), 2 subjects were past smokers (A.III.1 and A.III.3), and 1 was an active smoker (A.III.5). Neurologic examination was normal for CNS functions in the 9 subjects whom we directly assessed. For the 4 deceased subjects, the age of death ranged from 60 to 69 years. The causes of death were not neurologic. Subject A.II.1, whose genotype is unknown, died suddenly at age 6 months from an unknown cause. No other sudden death was recorded.
One patient (A.IV.4) had a unique seizure at age 19 years without recurrence in the absence of any therapy. Three subjects (A.III.1, A.IV.1, and C.II.3) had migraine without aura. Only 2 of the 14 subjects with COL4A1 mutations had a history of cerebrovascular injury. Patient A.III.3 had an acute cerebellar ataxia without vertigo lasting 2 days at age 47 years; MRI with diffusion-weighted imaging, performed only 8 days later, did not show any recent infarct. The diagnosis of brainstem minor ischemic stroke was retained, and investigations revealed neither cardiac nor large artery cause. Patient A.III.1 presented a posttraumatic cerebromeningeal hemorrhage at age 48 years, while the patient was receiving anticoagulants for venous thrombosis of the lower limb. A cranial trauma was indeed responsible for confusion, aphasia, and headaches related to a left temporal hemorrhagic contusion measuring 23 mm with adjacent subarachnoid hemorrhage. His mental status improved within 24 hours, and his language totally recovered within 4 weeks. Notably, his brother (A.III.5) had a serious brain trauma due to a car crash at age 30 years, with initial loss of consciousness and transient confusion lasting 1 day. No CT scan was performed. He denied any persistent neurologic deficit.
All patients showed retinal arteriolar tortuosity and had muscle cramps, with elevation of CPK, whereas 3 relatives without COL4A1 mutation did not have any retinal or muscular abnormalities.16 Renal involvement was observed in 10 patients, consisting of renal cysts in 4, hematuria in 7 (family A), and renal insufficiency in 5. Raynaud phenomenon was recorded in 6 patients, and supraventricular arrhythmia was recorded in 5.16
Brain MRI was performed in 9 subjects (mean age 39.4 years, 21–57 years), during the third decade of life in 4 of them and during the fifth and sixth decades in the other 5 patients. All but 1 affected subject (A.III.5, aged 44 years) showed at least 1 abnormality. Four patients had a combination of ICAs and CSVD, 3 had only CSVD, and 1 had an isolated ICA (tables 1 and e-1). Interestingly, no porencephaly was observed. Brain imaging performed in 1 unaffected relative (C.III.2) was normal.
A total of 12 ICAs were present in the 5 subjects with at least 1 affected member in each family: 3 of 6 in family A (A.III.3, AIV.2, and A.IV4), 1 of 2 in family B (B.III.2), and 1 of 1 in family C (C.II.3) (figure 1 and table e-1). Multiple ICAs were observed in 3 patients. All ICAs were asymptomatic and discovered on systematic radiologic examinations at ages ranging from 21 to 57 years. The majority of ICAs were small; only 1 was larger than 7 mm. The ICAs presented a large base of implantation without identifiable neck. All were localized on the intracranial carotid, at different levels of the carotid siphon. Six ICAs were extradural (1 on C4 and 5 on C3), and 6 were intradural (4 on C2 and 2 on C1). Eleven of the 12 aneurysms were localized on the right carotid, and 1 was localized on the left carotid. Additionally, 2 patients (A.III.3 and C.II.3) had dolichosiphons of both carotids.
Seven patients had MRI abnormalities consistent with a CSVD, including 5 of 6 in family A (A.III.1, A.III.3, A.IV.3, A.IV2, and A.IV.4), 1 of 2 in family B (B.II.1), and 1 of 1 in family C (C.III.3). All these 7 patients had WMC with a periventricular (5/7), subcortical (7/7), and/or subtentorial (3/7) distribution (table 1). Periventricular WMC showed an equal distribution between anterior, posterior, and lateral horns (figure 2). Subcortical WMC especially affected the frontal and parietal lobes, with the largest and most confluent lesions being observed in the inferoposterior areas of these lobes. Temporal and occipital lobes as well as U fibers were globally spared. WMC were predominantly located in the centrum semiovale and sometimes involved the external capsule and the posterior part of the posterior limb of the internal capsule (figure 2). Subtentorial WMC affected the core of the pons respecting the surface (figure 2). No cortical involvement was noted. In addition, 15 lacunar infarcts were observed in 4 patients (A.III.1, A.III.3, A.IV.2, and B.II.1), including 9 located in white matter (7 in the centrum semiovale and 2 in cerebellum hemisphere) and 6 in gray matter, all in the lenticular nucleus (table 1 and figure e-2). Five patients (A.III.1, A.III.3, A.IV.2, B.II.1, and C.II.3) had DPS in the basal ganglia and/or centrum semiovale (table 1 and figure e-2). Interestingly, only 3 (A.III.1, A.III.3, and C.II.3) of the 7 subjects investigated by T2* sequences had microbleeds, with 1 or 2 microbleeds per patient (table 1 and figure e-2). Patient A.III.1 had a 10-mm posttraumatic hemorrhagic lesion of the left external temporal region, but no other patient had a macrobleed.
Globally, CSVD seemed more severe in older than in younger patients; the Scheltens score was generally higher in the oldest generation (table 1). However, the severity of WMC was not homogeneous among patients of the same age. Indeed, the 44-year-old patient A.III.5 did not have any MRI abnormalities. Moreover, the 29-year-old patient A.IV.1 had very mild WMC in comparison with his 24-year-old brother (A.IV.2).
Significant ultrastructural anomalies were found in affected subjects although their skin had a completely normal appearance on physical examination and light microscopy. Replication of the lamina densa was observed at the dermoepidermal junction in the affected subjects of the 3 families (A.III.3, A.IV.4, B.II.1, and C.II.3; figure 3, A–C). The wall of dermal arterioles was also markedly altered. Vascular smooth muscle cells were dissociated, with abnormal spreading of the basement membrane (figure 3, D–F). The vessel wall had a normal appearance in the skin of a control sample, unaffected subject C.III.2 (data not shown).
Since the initial description of 3 distinct phenotypes associated with COL4A1 mutations that include autosomal dominant type I porencephaly (Online Mendelian Inheritance in Man [OMIM] 175780), cerebral small vessel disease with hemorrhages (OMIM 607595), and HANAC syndrome (OMIM 611773), identification of additional families now clearly indicates that autosomal dominant porencephaly and CSVD are part of a continuum with overlapping neurologic clinical and imaging features (table 2). This study focused on cerebrovascular disease in HANAC syndrome and revealed 4 distinctive features. First, although cerebrovascular lesions are common, they are usually asymptomatic in contrast with patients with prominent brain disease related to COL4A1 mutations, in whom various degrees of infantile hemiplegia, mental retardation, and stroke were commonly observed. Second, in addition to CSVD dominated by leukoencephalopathy, MRI analysis revealed unique or multiple aneurysms electively localized on the carotid siphon, which indicates that mutations in COL4A1 are not only involved in CSVD but also in large artery disease. Third, no patient with HANAC syndrome displayed porencephalic cavities, macrobleed, or a large number of microbleeds. Fourth, cerebrovascular disease in HANAC is part of a multiorgan disease with systemic vasculopathy as attested to by the results of skin biopsy.
In human and mice mutants with porencephaly related to COL4A1 mutation, the phenotype includes a high susceptibility to hemorrhagic strokes frequently triggered by birth trauma, brain trauma, or anticoagulant treatment.4,11 By contrast, in HANAC syndrome, only 1 of the 14 affected members had a small hemorrhage after a serious head trauma despite anticoagulant therapy. Another subject had a severe head trauma without any trace of cerebral hemorrhage on follow-up MRI. These findings strongly suggest that COL4A1 mutations underlying HANAC syndrome are associated with a lower risk of hemorrhagic strokes than COL4A1 mutations underlying familial porencephaly and CVSD. The absence of severe brain hemorrhages may be due to environmental and/or genetic modifiers. Mice with COL4A1 mutations also show important phenotypic heterogeneity,4,18 with a significant influence of the genetic background on the ocular phenotype.19 Because of the small number of families and patients with COL4A1 mutations described so far, a precise genotype-phenotype correlation with neurologic as well as systemic manifestations remains hazardous. Nevertheless, our data raise the hypothesis of a mutation effect on the phenotypic expression, because COL4A1 mutations responsible for HANAC syndrome are closely localized in a very narrow stretch of the gene, whereas other mutations usually affect more C-terminal glycine residues (table 2).
CSVD in HANAC syndrome is dominated by leukoencephalopathy affecting periventricular, deep regions and the pons. WMC were noted despite the young age of the patients and in the absence of vascular risk factors, such as hypertension, usually associated with WMC.20 The highest lesion load was observed in frontal and parietal white matter predominantly in posterior regions, especially in the centrum semiovale. The temporal lobe and arcuate fibers are spared in contrast with the abnormalities observed in CADASIL.21,22 Most of the WMC and lacunar infarcts were located in the territory of lenticulostriate small perforating arteries, leptomeningeal long penetrating arteries, and pontine perforating arteries with a pattern recovering partially those of WMC associated with hypertension and arteriolosclerosis.22,23
The severity of WMC seems to be variable between and within families with HANAC, suggesting the presence of genetic and/or environmental modifiers or subtle differences in the consequences of the different mutations. In a previously reported family of 6 affected members with a COL4A1 mutation but without HANAC disease, 2 subjects died of intracranial hemorrhage, whereas MRI signal abnormalities did not change after a follow-up period of 7 years in the other patients.24 These findings correspond with our data showing that COL4A1 mutation carriers may have a great diversity in clinical and radiologic expression of cerebrovascular injury.
COL4A1 mutations in HANAC syndrome constitute a new monogenic cause of familial ICAs with 55% of the affected patients. ICAs were previously described in only 3 patients from 3 different families with COL4A1 mutation but without HANAC syndrome5,7,12,13 (table 2). The other hereditary diseases associated with ICAs are rare and consist mainly of diseases of connective tissue and extracellular matrix such as autosomal dominant polycystic kidney disease and Ehlers-Danlos syndrome type IV with mutations in COL3A1.24–26 The extracellular matrix of the arterial wall plays an important role in strength and elasticity of intracranial arteries. Collagen types III and IV and elastin fibers are decreased in the wall of ICAs as well as in skin biopsies of patients with ICA.27 Moreover, genes encoding extracellular matrix protein, including COL4A1, have been associated with a susceptibility to ICA formation in the general population.28 In vascular basement membrane, COL4A1 forms a sheetlike network beneath the endothelium and surrounding smooth muscle cells.1,2 Our findings suggest that COL4A1 mutations observed in HANAC syndrome lead to a disruption of extracellular matrix and a remodeling of the vascular wall with the formation of ICA.
A surprising fact about ICAs in HANAC syndrome was their elective localization on the carotid siphon both on intradural and extradural segments. The collagen type IV network is essential for the cohesiveness of basement membranes under conditions of increasing mechanical demands.29 The carotid siphon constitutes a peculiar zone due to the conjunction of a high blood flow and a tortuous curving form. In HANAC syndrome, the occurrence of basement membrane defects in this area, which is subject to high mechanical stress, may predispose to ICA formation in the carotid siphon. Intriguingly, no patient had a spontaneous subarachnoid hemorrhage, which may be due to the small size of these ICAs or to a low risk of rupture of aneurysms associated with COL4A1 mutations.
In addition to CSVD and ICA, COL4A1 mutations in HANAC syndrome are responsible for a multiorgan disease affecting the kidney, the musculature, and the retinal small arterioles, which seems to be the hallmark of the syndrome. The ultrastructural alterations observed in the skin, particularly in dermal arterioles, demonstrate a systemic vasculopathy. Interestingly, skin biopsy also shows changes in blood vessel morphology in 2 autosomal dominant cerebral angiopathies: CADASIL (OMIM 125310) due to mutations in the NOTCH3 receptor and hereditary endotheliopathy with retinopathy, nephropathy, and stroke (HERNS), a distinctive subtype of RVCL caused by mutations in TREX1 transcription factor.30,31 Patients with CADASIL and transgenic mice expressing mutant Notch3 show an enlargement of the inter–smooth muscle cell space, in skin vessels and tail artery sections. These anomalies precede the accumulation of granular osmiophilic material in transgenic mice.32 In HERNS, the brain disease is associated with renal abnormalities, Raynaud phenomenon, and retinal vasculopathy with ultrastructural alterations affecting capillaries in the brain and other tissues,33 but with a distinct feature from HANAC syndrome. Skin biopsy may provide a cost-effective guide before practicing an expensive and time-consuming genetic screening of COL4A1 mutations.
Sonia Alamowitch and Emmanuelle Plaisier designed the study, retrieved the data, and drafted the report. Pascal Favrole and Béatrice Marro retrieved the clinical and radiologic data. Catherine Prost and Zhiyong Chen retrieved the data of skin biopsy. Tom Van Agtmael helped with the interpretation of the data. Pierre Ronco initiated the project and contributed to design and revision of the report.
The authors thank Safa Benhassine and Marie-Chrisine Verpont for technical assistance.
Dr. Alamowitch serves on the editorial committee of the Revue Neurologique. Dr. Plaisier, Dr. Favrole, Dr. Prost, and Mrs. Chen report no disclosures. Dr. Van Agtmael receives research support from the Medical Research Council UK [G0601268 (PI)]. Dr. Marro reports no disclosures. Dr. Ronco serves as a Section Editor for Nephrology Dialysis Transplantation and serves on the editorial boards of the Journal of American Society of Nephrology, Nature Clinical Practice Nephrology, and Kidney International; and has received research support from Amgen SAS.
Address correspondence and reprint requests to Dr. Sonia Alamowitch, Stroke Unit, Department of Neurology, Tenon University Hospital, AP-HP, 4 Rue de la Chine, Paris, France email@example.com
Supplemental data at www.neurology.org
*These authors contributed equally to this work.
Supported by grants from INSERM, Université Pierre et Marie Curie–Paris 6 (BQR and legs Tessier), Assistance Publique–Hôpitaux de Paris (Délégation à la Recherche Clinique, Contrat CIRC), Association pour l'Utilisation du Rein Artificiel (AURA), Agence Nationale de le Recherche (ANR-08-Genopath-018-02), and Délégation Générale à la Santé, and through Coordination Theme 1 (Health) of the European Community's 7th Framework Programme (grant agreement no. HEALTH-F2-2007- 201590). T.V.A. is supported by an MRC New Investigator Research Grant.
Disclosure: Author disclosures are provided at the end of the article.
Received April 19, 2009. Accepted in final form September 9, 2009.
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.

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Checking out her new threads...sadly, she has graduated to size 3-6 months.
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Blakely McMullan, a 6-year-old from Ocean Isle Beach, recently secured first-place finishes at the Wilmington Swim League Championships at Cape Fear Country Club.
McMullan was a team member of the Southport/Oak Island Marlins swim team this summer. The season began in May and concluded at the championships, which were held the last week of July. The Wilmington Swim League is comprised of 13 teams, including the Marlins and 12 teams from the Wilmington area.
Not much has changed with fishing here in Brunswick County. Last week our region did experience a push of cooler weather that ignited a short-lived beachfront king mackerel bite. Other than that run, it has been all about the summertime heat. For some, these hot, humid conditions might mean good days to lay on the beach and tan, but for fishermen, it means tough fishing.
Anthony "Bubba" McCray recently competed in the 2017 East-West All-Star Game. During that game, he took a handoff around the left side and scampered for 37 yards, the longest carry of the contest for his East squad.
Football fans in Shallotte are going to miss the sight of McCray blazing past defenders, his dreadlocks flopping in the wind on the way to a 60-yard touchdown run.
You see, West Brunswick High School football is back, but McCray is gone.
WILMINGTON - Three county high school football teams have waited an entire offseason for this night.
The 31st Annual BB&T Football Jamboree kicks off the 2017 high school football season Friday night at Legion Stadium in Wilmington.
West Brunswick squares off against New Hanover in the first scrimmage contest of the evening, while county foes North Brunswick and South Brunswick meet in the third tilt.
Gates open at 4:30 p.m. and the first scrimmage begins at 5:30 p.m.
West Brunswick High School is coming off one of the most successful seasons in the last 20 years of the football program.
The Trojans, who enter their third season under the leadership of head coach Kelly Williamson, finished the 2016 campaign with a 9-4 record. They advanced to the second round of the NCHSAA 3A state playoffs before dropping a tight contest against Jacksonville.
A Wilmington man has been charged in the death of a man who died of a drug overdose last year in Sunset Beach.
Hunter McRae Morgan, 36, was arrested Tuesday, Aug. 8, on charges of involuntary manslaughter, conspiracy possession with intent to sell or deliver a counterfeit controlled substance and selling or delivering a counterfeit substance.
BOLIVIA — The Brunswick County Board of Education approved a balanced 2017-2018 school year budget during its Tuesday afternoon work session.
Board members Charlie Miller and John Thompson were absent from the meeting.
SUPPLY — Levi Grissett still doesn't care much to eat his vegetables, but he sure loves to grow them.
The Brunswick County native's latest summer crop consists of a tall row of heirloom butterbeans towering over his backyard garden at his home on Empire Road, he estimates between 18 to 20 feet high.
"The fantastic thing about those beans is they've been in my deep freeze for 10 years — I've had 'em since '07," the retired trucker said as he stood on his own expansive family heirloom property.
SUNSET BEACH — Town council has given unanimous approval to the state-enabled "brunch bill," which allows a town to choose whether to allow sales of alcoholic beverages starting at 10 a.m. instead of noon Sundays.
Councilman Richard Cerrato was an involuntary part of the unanimous vote count after he tried to recuse himself from voting on the issue at council's monthly meeting Monday night, stating while he has ownership in a local restaurant it is not directly affected by the measure.
Copyright © 2017
The Brunswick Beacon is your source for local news, sports, events and information in Brunswick County, North Carolina and surrounding areas.


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Don't Cry Over Spilt Milk! Khutzeymateen Grizzly Sanctuary, Great Bear Rainforest (northern BC coast). June 1, 2013.
No need to cry over spilt milk - even Ma isn't too worried that her two cubs are being a little sloppy as they nurse on an exposed sand bar in the Khutzeymateen estuary!
This female grizzly has to rank high in the animal kingdom's "world's best mom" competition. She's ever-vigilant and her two cubs - now in their 3rd spring - seem as healthy as can be (despite the fact that they're living in an area literally crawling with large and hungry male bears!). This was a real special moment - we had seen ma nursing her cubs many times before, but she always took them into the surrounding forest and all we got were quick glimpses between the leaves and branches. But this time, Ma just walked to a high spot on a sand bar and, in plain view, laid down and let the cubs dog-pile on top of her and begin suckling away! And, as is visible in this photo, the cubs were pretty unconcerned about how much of a "mess" they made on Ma's chest! I suspect she did feel just a tad exposed (so to speak) - she made a point of looking up every few moments as though she was checking that we were behaving ourselves and keeping a respectful distance!
This fantastic photo op presented itself when I had a Nikkor 500mm f4 VR lens mounted on my D4 body (yep, darned lucky). I don't own a 500mm f4 (it was a friend's lens and he lent it to me while he tried out my 400mm f2.8 VR) but a few years back I borrowed one from Nikon to test and compare it to my own 400mm f2.8 VR and 600mm f4 VR. My impression "way back then" was that it was somewhat easier to hand-hold than its significantly heavier relatives (the 400mm f2.8 VR and the 600mm f4 VR). Since that time I have shot both of the big monsters hand-held a lot and have gotten quite used to it. And, when I picked up the 500mm f4 this time, it felt like a lightweight lens (hey - everything is relative)! I have to say I really enjoyed shooting the 500mm f4 and I can fully understand why many photographers opt for the 500, especially if they might be forced to hand-hold their super-telephoto lenses.
Does this mean I'm considering selling either or both of my other big lenses and replacing them with a 500mm f4 VR? Nope. I love the speed, sharpness and contrast of my 400mm f2.8 VR and consider it my #1 "go-to" wildlife lens. And, when the opportunity is right (meaning I need more reach than my 400 provides), I just love what the 600mm f4 VR can do (even hand-held). But I AM splitting hairs - to be honest you can't go wrong with ANY of the Nikon's "big three"...and most shooters would likely get the most mileage and use out of the 500, largely owing to its noticeably lighter weight and ease of handling. It's not impossible I will add a 500mm f4 to my "stable" of lenses sometime in the future.
Here's a higher resolution (2400 pixel) version of the shot for those wanting to see more detail:
Don't Cry Over Spilt Milk! Download 2400 pixel image (JPEG: 1.1 MB)
1. This image - in all resolutions - is protected by copyright. I'm fine with personal uses of them (including use as desktop backgrounds or screensavers on your own computer), but unauthorized commercial use of the image is prohibited by law. Thanks in advance for respecting my copyright!
2. This image was captured during one of my two spring "Grizzlies of the Khutzeymateen" photo tours in May/June of 2013. Each year I offer trips into two different parts of the Great Bear Rainforest as well as one to photograph aquatic mammals and oceanscapes near the northern tip of Vancouver Island. And, in selected years, I also offer photo tours to locations to capture other highly sought-after subjects, such as various boreal owl species and wildlife of Canada's Arctic. Details about these trips can be found on the Photo Tours page of this website.
3. Like all wildlife images on this website, the subject(s) is/are fully wild and completely unconstrained. Besides the potential impact of my/our presence, nothing has been done to intentionally alter or affect the ongoing behavior of the subject and, of course, there has been no use of any form of bait or other form of wildlife attractants/luring devices (including vocalizations or other sounds).
Don't Cry Over Spilt Milk! Khutzeymateen Grizzly Sanctuary, Great Bear Rainforest (northern BC coast). June 1, 2013.
Digital Capture; Compressed RAW (NEF) 14-bit format; ISO 1000.
Nikon D4 paired with Nikkor 500mm f4 VRII prime lens - hand-held from floating Zodiac. VR on and in normal mode.
1/500s @ f8; -0.33 stop compensation from matrix-metered exposure setting.
Don't Cry Over Spilt Milk! Khutzeymateen Grizzly Sanctuary, Great Bear Rainforest (northern BC coast). June 1, 2013.
RAW Conversion to 16-bit TIFF, including first-pass/capture sharpening using Capture One Pro version 7. Two raw variants (images processed from raw) differing by a total of 0.4 stops in total exposure.
Further digital corrections on resulting 16-bit TIFF files using Adobe's Photoshop CS6 and Light Craft's Lightzone. Photoshop adjustments included compositing the raw conversion exposure variants, selective minor tweaks to exposure and contrast (using selective curves adjustment), and selective sharpening for web output. Final tone tweaking performed using tonemapper/re-light tool in Lightzone.
Don't Cry Over Spilt Milk! Khutzeymateen Grizzly Sanctuary, Great Bear Rainforest (northern BC coast). June 1, 2013.
Ten percent of the revenue generated by this image will be donated to Raincoast*.
Species Status in Canada**: Special Concern (May 2002).
While Grizzly Bears (Ursus arctos) are not technically listed as "Endangered" in Canada, they have been extirpated from most of their historical range. Grizzly Bears are far more sensitive to intrusion/disturbance in their habitat than are Black Bears and are being increasingly forced into marginal habitat by human encroachment. The Great Bear Rainforest along the central and northern coast of British Columbia is one of the last strongholds of the Grizzly Bear in Canada, and even this population is coming under increasing pressure.
Sadly, because these bears reside in BC, there's a very real chance that their lives will be ended by a bullet. And, their heads and paws will be cut off (leaving their carcasses to simply rot) so that they can be mounted and adorn the wall of some fearless trophy hunter (who will, no doubt, be cheered on by all the grasses, sedges and clams that will be saved from being so mercilessly eaten by these fearsome beasts).
The debate about the trophy hunting of carnivores can be broken into 3 arguments: the ethical, the economic, and the ecological. The ethical argument for the trophy hunting of grizzlies in BC? On that one - just go back and look at this image and read the paragraph immediately above. The economic argument? Well, it's on even shakier grounds - not only does bear-watching in BC generate 11-15 times as much revenue as bear hunting (and employ 10-15 times as many people), but the revenue generated by bear hunting doesn't even cover the cost to the BC Gov't of managing the hunt itself - it's a net loss to the taxpayers of BC (all studies related to these economic claims can be supplied on request). The ecological argument? Yep, you guessed right - there isn't one. As a matter of fact, an increasing body of sound, peer-reviewed scientific studies have shown how the guild of carnivores at the TOP of the food chain are exceptionally important to the overall health of ecosystems - everything from ensuring continued biodiversity through to maximizing that amount of carbon dioxide the ecosystem can absorb (climate change consequences, anyone?).
So why does the trophy hunting of carnivores (and bears in particular) continue to exist in BC? Good question. Well, it sure isn't because of public support - just under 90% of British Columbians are against it. And many First Nations have banned it in their territories. Sadly, it appears that little more than the fact that a handful of elected officials (MLA's) in a few rural ridings fear the backlash from voters if they stand against trophy hunting is keeping trophy hunting alive.
Those wishing to get active in helping to stop the trophy hunting of carnivores in BC are encouraged to visit this page on Raincoast's website. And please help spread the word!
*The Raincoast Conservation Society (and Foundation) is an effective and efficient organization that has been fighting for protection of this unique habitat. If you are looking for a meaningful way to contribute to the conservation of this amazing ecosystem, Raincoast will provide maximal "bang" for your conservation dollars.
**as determined by COSEWIC: The Committee on the Status of Endangered Wildlife in Canada


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Baahubali 2 2nd, 3rd day Box Office Collection 1st Saturday Business Income Report
Baahubali 2 2nd, 3rd day Box Office Collection 1st Saturday Business Income Report
Baahubali 2 already made record on day 1 with highest box office collection at both domestic and overseas box office ever in Indian Movie Industry. According to Film maker Karan J tweet Actual Baahubali 2 Opening day collection is Rs 152 Cr including all language at domestic box office while including Overseas Box Office Collection which is Rs 60 Cr (Rs 30 Cr from USA alone) the Total 1st day income has crossed Rs 212 Cr milestones. That's a biggest record breaking amount ever made in Indian Cinema. These figures are unexpected, unbelievable and shocking for every one of us at the same time for all Baahubali lovers this is Baahubali day. Now in this post we will talk about in detailed for Baahubali 2 2nd day box office income. If you want to know more regarding day 1 collection then visit our dedicated
post on
Baahubali 2 first day Box Office Domestic and Overseas Collection
{Rs 450 Cr+}* Baahubali 2 Second Day BO income total collection till now
Actual figure for day 2 box office collection of Baahubali is not compiled yet but the rough or raw figure we have got from our sources that we will share with you. As like Day 1 Baahubali 2 achieve more income on day 2 due to holiday on Saturday and much more bookings as compared with that of first day or opening day of Baahubali 2.
We have received raw figure is that Rs 400 Cr+ which is total Box Office Collection of Baahubali 2 including day 1 and day 2 collection. That means on the second day also Baahubali 2 was successful to achieve same or more income than opening day at both domestic and overseas box office.
Expected Baahubali 2 3rd day Income, 1st Sunday weekend Business Worldwide Till Day Today
So simply anyone can expect around Rs 700 Cr + income from Baahubali 2 total 1st weekend box office collection. Other big starrer movie are hardly able to think for gross box office collection lifetime to be Rs 500 Cr+ but Baahubali 2 will achieved the same total in 3 days only. It will be interesting to see in how many days Baahubali 2 will beat PK (Rs 792 Cr) at Highest Box Office Collection. We are also maintaining exact, real time and accurate Box Office Collection of Baahubali 2 for you all at the right hand side of our blog in a dedicated table. So that you will have actual and correct information related to the Baahubali 2 box office income/collection with you. Please stay tuned with us for more news and updates regarding your all time favorite Baahubali 2.


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French foreign affairs minister calls US strike in Syria a 'warning'
By RFI on April 7, 2017
RFI — French Foreign Affairs Minister Jean-Marc Ayrault said on Friday that the United StatesтАЩ missile strike targeting a military base in Syria was a тАЬcondemnationтАЭ of the тАЬcriminal regimeтАЭ of Bashar al-Assad.
The minister told reporters during an official visit in Mauritania on Friday that US Secretary of State Rex Tillerson had informed him of the impending strike on Thursday night.
The US fired 59 Tomahawk cruise missiles from two naval destroyers, the USS Porter and the USS Ross, based in the eastern Mediterranean, at 3.40am Syrian time on Friday. The strike targeted Shayrat Airfield, a military base south of Homs.
At least six Syrian soldiers were killed, according to the UK-based monitoring group Syrian Observatory for Human Rights, which added that тАЬthe airbase was almost completely destroyedтАЭ.
The strike came just days after a suspected sarin gas attack in the rebel-held town of Khan Sheikhun killed nearly 80 people, including dozens of children, and wounded hundreds more. US President Donald Trump has accused Assad of carrying out the тАЬbarbaric attackтАЭ.
The┬аuse of chemical weapons is a sad reality,тАЭ said Ayrault. тАЬWe know this, in spite of the denial, the lies and the propaganda of Bashar al-AssadтАЩs regime.тАЭ
тАЬItтАЩs unacceptable, itтАЩs even unbearable, and it must be punished as a war crime,тАЭ the minister said of the suspected chemical attack. тАЬThe international justice community must give a verdict on Assad and his crimes.тАЭ
However, he added that France тАЬis not at war with Syria.тАЭ
тАЬWe are only fighting the Islamic State armed group (IS) and we have no intention of participating in this war in Syria.тАЭ
Ayrault stressed that тАЬit is now more important than everтАЭ to restart peace talks. тАЬWe must begin negotiating for a political transition, for reconstruction of the country, and for the return of refugees, and it wonтАЩt be done with Bashar al-Assad.тАЭ
Strategy change-up
The US missile strike has escalated American involvement in SyriaтАЩs ongoing civil war, marking a point of departure from Obama-era foreign policy regarding military intervention in the country.
тАЬIt crossed a lot of lines for me,тАЭ said Trump of the Khan Sheikhun incident.
The presidentтАЩs statement was a thinly veiled reference to former US president Barack Obama, who ultimately decided against enforcing what he called the тАЬred lineтАЭ on the use of chemical weapons in Syria in 2013.
Trump announced the strike, his biggest military decision since assuming the presidency, in a televised address on Friday just hours after the UN Security Council failed to agree on a probe into the suspected gas attack.
тАЬTonight I call on all civilised nations to join us in seeking to end this slaughter and bloodshed in Syria, and also to end terrorism of all kinds and types,тАЭ he said.
The US president described the strike as being of тАЬvital national security interestтАЭ.
International reactions
Syria has denied the use of chemical weapons and called the US strike тАЬan act of aggressionтАЭ.
Its Russian ally has also denounced the military action. Kremlin spokesman Dmitry Peskov described it as an тАЬaggression against a sovereign stateтАЭ that could potentially do тАЬconsiderable damageтАЭ to US-Russia relations.
Backers of the US-led coalition in Syria have declared their support, such as Israeli Prime Minister Benjamin Netanyahu, who said that Trump тАЬsent a strong and clear message that the use and spread of chemical weapons will not be tolerated.тАЭ
German Foreign Minister Sigmar Gabriel said the strike was тАЬunderstandableтАЭ following the suspected sarin gas attack, while Shinzo Abe, JapanтАЩs Prime Minister, said his country тАЬsupports the US governmentтАЩs resolveтАЭ.
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It's the beginning of a new week, and that means it's time for a new Artist Spotlight. If you are new to the blog, this is a weekly feature, where we showcase artist and photographers whose work has caught our eye. If you would like to be featured, or know of someone we should check out, please let us know. We are always looking for fresh faces.
This week, the spotlight is on Montreal photographer Michelle Karpman. Michelle caught our eye through Instagram. I (Justin) happened to stumble upon her through her liking some of our posts. I was instantly drawn to her work. I was able to see another side of her work too, when I found the model that she works with on Instagram. Soon I connected with Michelle on tumblr as well, and I realized that there was no way we couldn't have her on Snap It See It. So take the time to look at her work, and give her a follow. You wont be disappointed!
Portfolio | Tumblr | Instagram
A little about yourself. Where you are from and what you do?
I'm from Montreal, Quebec, and I'm a full time student. I'm hoping to stay in school for as long as possible so as to avoid getting a real job, being responsible, growing up – all the fun things real adults do. Next year I will (hopefully!) be starting my masters in English Literature (so obviously there will be no employment for a long time). I fill all my non-school time with photoshoots with my best friend/model Aviva Artzy; that girl who's in every picture. We run Amamak together (amamakphoto.tumblr.com) and spend most of our time futzing around shooting, organizing, and planning future photo adventures.
How did you get into instant photography?
A lot of the people I had been following at the time were taking really beautiful Polaroids and I wanted to get in on the fun. This was about five years ago, and I'd already been shooting with Aviva for a while, but only medium format film. I decided to buy an SLR680, stock up on a ton of Polaroid film, and give it a go. I'm down to my last 10 packs or so and I am looking forward to shooting them this summer!
What is your favorite camera used for instant photography?
I used to be set on my SLR680, but now that I mainly shoot Impossible films I prefer the SX-70. Something about the SX-70 and Impossible tones makes for magic in a way that the 600 film can't yet seem to pull off.
What instant camera have you not shot with, but would love to try?
This is actually a very difficult question! Every time I learn of a new instant camera I have a terrible – and expensive – habit of buying it. So I own most of the instant cameras that have interested me over the years. I am open to suggestions though! Feel free to feed my addiction.
What's your favorite Impossible film or pack film type?
I'm a huge fan of PX70
How have you incorporated instant film into your regular workflow?
Every shoot includes at least two instant cameras – the SX-70 and SLR680, and sometimes the 600SE if I'm not trying to travel light. I shoot about a pack a shoot, because it's amazing seeing something develop (if slowly) during the shoot itself and also because I've learned that leaving the film in the camera can make it go all wonky. As if we needed another excuse to shoot more! This year Aviva and I have shot more instant shots than ever before, and have recently put out a little book of our favourite Polaroids.
How would you describe your voice or vision with instant photography? (does it differ from your other work?)
I aim for something naturey, sun-filled, and comfortable. Aviva and I luckily share an artistic vision defined by pink sunsets and a, "I'm a faerie sprite who is just casually exploring this forest" feeling. With my instant work especially, I try to get as much sun and glow as possible. I think there's something so magical about the way instant films take sunlight and, when you're lucky, sun flare.
Any personal projects we should know about?
We're just gearing up for an onslaught of spring shoots! After months of cold and snow we're excited to finally venture into the outdoors. We're also trying to figure out a way to put out some less expensive print stuff – like a zine, or a smaller, locally-made book. There's nothing like seeing your work in print!
What other photographers do you look up to?
Oh a bunch of people – Jared Chambers, Jon Duenas, Josh Soskin, Matt Fry, and a million more I can't think of. I've also recently become a fan of some wedding photographers, mainly Jeremiah & Rachel photography. If you never thought you'd like wedding photography but are a fan of fine art film photography, you should check these guys out.
What advice would you give to someone just getting into instant photography?
Buy a lot of film and don't be scared to use it! I know Impossible film is crazy expensive, but if you can somehow save up a bunch of money and then not think about how much each picture is costing you, you'll have way more fun and also get much better at this whole instant photo thing! Also shoot on overcast days or in the shade – figuring out how to not overexpose photos in the sun is headachy.
Where does your inspiration come from? Do you seek it out or wait till it finds you?
I like looking at pretty things, so I spend about 90% of my time online looking through Tumblr and Flickr and Instagram. If I didn't take pictures I'm pretty sure I'd do the exact same thing. Every once in awhile I'll see a particular photo that will make me want to do something similar, but more often than not all the pictures I look through just help to remind me why I do what I do.


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The Best Acting Performances by Christian Bale
I'm gonna go ahead and make a gutsy call here. I think that Christian Bale is the white Will Smith. What do you guys think about that? Seriously. Give it a moment. Aside from not being a music or television star and starting off as a rapper, they're pretty similar. All jokes aside, they're both huge action stars now and unfortunately we don't see these guys in great "acting" roles much anymore.
I mean Bale is a rugged, pretty big dude who is Batman. And as such he's been in other action type movies like Reign of Fire and Terminator Salvation. By no means is he a type casted actor but Bale is definitely now considered an action star.
That however, was not always the case. And I've selected seven movie roles that show how good of an actor Bale really is…..
Empire of the Sun – Jamie Graham
For some reason people fail to realize that Bale was in this movie. I think it's extremely underrated and I think that Bale simple didn't get enough praise for it. After all he was just a kid. And standing toe to toe with John Malkovich in a Steven Spielberg directed movie is no easy task. He was only 13 for this film.
American Psycho – Patrick Bateman
Anyone who is a big fan of Christian Bale would probably consider the role of Patrick Bateman to be their favorite. To this day people still say things like "I have to go return some video tapes" or "I have a meeting with Cliff Huxtable." What a great movie but certainly made much better by the dark, obsessive Bateman character that Bale so finely portrayed. And Jesus talk about role preparation. Could he have been more ripped in this movie? Good Lord.
Metroland – Chris
Most people I know haven't seen this film and I happened to have loved it. It's about a suburbanite who realizes how boring his life is when his buddy from the past comes to visit him. He thinks of a life that once was and explores the idea of living it again. A free life where he can have sex with women other than his wife. Bale looks really "British" in this movie but he's awesome in it. Not that there's anything wrong with looking British.
The Prestige – Alfred Borden
Talk about an awesome movie. I mean how can you go wrong with Christopher Nolan. Of all the films they've done together this is by far the best Bale has acted. I mean playing Batman is acting yes, but it doesn't seem too challenging to lower your voice when you're in the cape and to be a Playboy when you're out of it. In the Prestige he's playing multiple roles and he was excellent.
The Machinist – Trevor Reznik
Losing that much weight is enough to show what kind of dedication Bale had. It was gross seeing how emaciated he was. But the movie itself was awesome and Bale nailed his part as basically a neurotic insomniac who barely touches food and tries to make sense of his own life nightmare. I won't ruin the entire plot.
Swing Kids – Thomas Berger
This movie didn't become too popular. I think it was because of the subject matter. People don't like seeing Nazi type movies that involve teens. However, Bale nailed his role as a once swing kid turned Nazi. It's a great role for character transformation as you see him move to once party animal to strict Nazi officer.
*The Fighter – Dickie Eklund
I'm just making a gutsy call here. The movie hasn't come out yet but you can tell that Bale is going to nail this role. The movie's based on a true story and Bale had someone he could study off of. Plus, hair and body transformation yet again. I feel like Bale loves doing this shit.
*He was pretty solid in Equilibrium2 Comments
I don't know about the "white Will Smith" hehe,
but he is truly an amazing actor.
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Flying? The closest major airport is Raleigh-Durham International Airport (RDU).
The airport is about 20 miles from Chapel Hill, so you will need to take a taxi or rent a car. A taxi ride to Chapel Hill costs approximately $40. For more information visit the RDU Ground Transportation page.
Coming by Train? The closest Amtrak Station is in Durham, about 17 miles from Chapel Hill. From Durham you can take TTA Bus No. 400 from the station to the UNC Campus. It takes about an hour and costs $2.25.
Driving? Directions to UNC Visitor's Center (central campus)
Campus parking is in high demand and short supply. We are not able to supply campus parking permits and recommend that visitors park in Chapel Hill city garages. The Wallace Deck on Franklin Street (lot 18 on the map) offers parking near campus for $1.50/hour or $7 flat fee for day if you arrive before 9 am and leave after 6 pm. The 140 West Parking Garage (lot 10 on the map) is another parking option near campus. For more information on city parking options, visit the Park on the Hill site.


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Before You Remarry, Revisit Your Estate PlanJanuary 22, 2014 9:21 pm Asset Protection, Estate Planning
If you are planning to remarry soon, you have probably given some thought to how this new marriage will impact your finances and that of your old and new families. Before you take your next trip down the aisle, you both should review your estate plans with the following in mind:
Asset management – both of you need to create a list of your separate assets, including IRAs, brokerage accounts, bank accounts, retirement plans, pensions, life insurance policy, etc., and then decide which of these you plan to combine and which you plan to keep separate.
Asset plan – if one or both of you have children you are bringing to the new marriage, then you need to plan for how they will be included in your estate plan and wills. You may want to consider creating a trust or buying additional life insurance to cover children.
Estate plan — consulting with an estate planning attorney is important, whether your assets are great or small. If you have an existing estate plan and you remarry, you need to update your will, living will, powers of attorney, HIPAA authorization, and change the beneficiary designation on your qualified retirement and life insurance plans. And if one spouse is bringing significantly more assets to the marriage, you may want to consider a prenuptial agreement to protect assets.
Whenever a major life event brings change to your family circumstances, contact our Orange County law firm to review or update your estate plan.


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|Home | Products | Services | Support
|Introduction | Download | Buy | Online Help | Developers | Awards
NetLegger Systems is proud to introduce LargeEdit 1.0. This editor is an all-in-one productivity tool for everyone that works with text files. LargeEdit has something to offer everyone;
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Do you use big, slow loading editors just for the syntax highlighting. It's understandable, syntax highlighting makes code easier to read, but now you don't have to wait for those bloated editors to load up. LargeEdit provider syntax highlighting for; Javascript, VBScript, HTML, C++, Java, ObjectPascal, Visual Basic, Cascading style sheets, PHP, XML, Perl, Fortran, Foxpro, SQL, INI, x86 assembly, MS DOS Batch, and AWK Script.
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Forget a function or tag name, use the code completion editor to add frequently forgotten code. Simply press CTRL+Space to invoke the code completion window.
Keyboard Macros
Increase your productivity with keyboard macros, no more repetitive keystroke sequences, simply record your keystroke sequence once and play it back as many times as you want. You can also save your keystrokes for later use.
Extended Find & Replace
Are you sick of wasting time copying and pasting a block text from file to file in order to replace an existing block of text. Use Extended Find and Replace to search and replace blocks of text inside multiple files. LargeEdit can scan a selected directory and its sub-directories for matches.
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LargeEdit's integrated FTP lets you open and edit files from a remote server, saving automatically transfers the updated file back to the remote server.
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Data files are now easier to navigate and update. No more counting commas or tabs to find the field you want, you can even make your changes directly in the grid.
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Windows macros, spell checker, delete data field, run file, print preview, email, export(HTML,RTF), block select, case converter, bookmarks, ASCII & HTML Codes, XPath Search, and HTML Colors.
Click here to register, if you already a registered user click here to login
|© Copyright NSI


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Black&Decker 6.5-Quart Multicooker review
The amazing design sense, creativity and simplicity is what makes the Black+Decker 6.5 Quart Multicooker stand out against its competition. This product can carry out multiple varieties of cooking job and as per customer's reviews; it is very effective in all of them. But the million dollar question is, why customers should buy this product for $130, when they have an option to buy cheaper alternatives which claim to be equally good.
This Black & Decker multicooker claims to be very effective in 3 basic kitchen tasks – slow cooking, sear/sauté and roast/bake. Out of all three, we got best result with Roast/bake and we can easily say, for roast/bake this product is a superior option in comparison to its competition. We found this product to be equally useful for slow cooking and sear/sauté jobs as compared to the traditional multicooker models.
We must mention here that the baking experience was not as enjoyable in Black & Decker Multicooker as compared to other tasks. The biggest problem was finding a sheet/pan that could easily fit in to the cooker. We baked numerous items in this cooker, the result was outstanding each time. But for a product priced at $130, the company should provide a right size baking pan with the product.
Talking about drawback, there are two things that we must mention. The cooker does not come with an in-built timer and the slow roast function could have been made better. Now, keeping in mind the price of product which is just above $100, these drawbacks are completely avoidable.
Having a multicooker in your kitchen is sure to add more value to your cooking experience. Most models are very convenient to operate, helps you save a lot of time and while occupying very less space on your counter, gives numerous cooking options.
This multicooker from black and decker helps you avoid turning on the full-size oven every now and then for small cooking jobs. But for a price of $130, it is bit expensive for this product range. There are cheaper models from brands like instantpot and Panasonic, which perform better or at least equally good.


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Back in 2014, BBC Radio 1Xtra rightfully earned flack for its list of the twenty most powerful entertainers in the UK's urban music scene, on which Ed Sheeran held the number one spot. The most attentive listeners of Sheeran's may recognize Sheeran's Saltine cracker jams to be anything but urban, and in fact, this seemed like Sheeran's whole selling point: he's an inoffensive presence whose Hallmark tales of love and heartbreak are just generic enough to be identifiable to the lowest comment denominator. Someone, at some point, however, decided that if Sheeran wasn't lovingly accepted by all as a representative of Black music coming from the UK, he would be in short time. That can be the only explanation as to why Sheeran decided to rap as much as he does on Divide, his third studio album—and the worst part is, Sheeran's embarrassing brand of "fish n' chip"-hop is far from the only problem with this record.
Review: 'Drunk' by Thundercat
You've heard Stephen Bruner, stage name Thundercat, even if you've never heard of him. The Los Angeles-born bass guitarist extraordinaire has long played a background role in hip-hop, having appeared in recent years on Mac Miller's GO:OD AM, Childish Gambino's Because the Internet, and the latest two projects from Kendrick Lamar. He's a moldable presence capable of adapting to a stylistically diverse soundscape, even serving as the bass player of crossover thrash group Suicidal Tendencies for a number of years. On Drunk, his third studio album, Bruner displays a masterful flexibility of tone, even if he occasionally veers into sonic homogeny.
Review: 'Prisoner' by Ryan Adams
It was fitting that Ryan Adams's previous full-length album was a front-to-back cover of Taylor Swift's award-winning 1989. Both artists have made careers out of amplifying their intimate stories into anthems while retaining the specificity of their songwriting—Adams, at the time, was going through a divorce with his then-wife Mandy Moore, and Swift's tales of structurally-unsound young love translated well to weariness, Adams's degradation of relationship reflected in the somber acoustic guitars comprising much of the album.
It's a principle that hasn't waned, despite the more uniformly electric soundscape occupying Prisoner. From the outset, Prisoner proves to be a way's away from his 2000 debut solo album Heartbreaker, a Nashville purist's wildest fantasy, but Adams even deviates from his bluesy 2014 self-titled album, the last original material we'd heard from him. It's almost as if he needed 1989 as a middle ground to metamorphose, its pop sensibilities transforming him into a full-fledged heartland rocker. The sun-drenched organs and guitars of the opener, "Do You Still Love Me?," evoke Bruce Springsteen in the late '80s, and on "Doomsday," his declarations that "My love, we can do better than this" soar over crashing acoustic guitar riffs. On the whole, Prisoner isn't too far off from a Tom Petty and the Heartbreakers record, but its larger-than-life sound and raw sense of emotional turbulence fit the kind of grand arena orchestration that defined acts like Springsteen and Petty thirty years ago.
Review: 'I Decided' by Big Sean
"Throughout my life, I always felt like I got a second chance at everything somehow," Big Sean told Trevor Noah on The Daily Show late last month. Second chances and the process of reinvention have always marked the Detroit rapper's career. Long gone are the days of strip club anthems set to MC Hammer samples; two years ago, Sean took a plunge into the moody, inky Dark Sky Paradise, his most ambitious project to date, while I Decided offers the most sonic diversity of his career. But as admirable as Big Sean's penchant for rediscovery is, it's only extended as far as the instrumental spaces he inhabits. I Decided still suffers from the same problem that every other Big Sean album does: Big Sean himself.
Review: 'Culture' by Migos
"And I really wanna thank the Migos—not for being in the show—but for making 'Bad and Boujee.' Like, that's the best song ever."
Donald Glover isn't the only one to think so. Despite seeing relative success with singles in the past like "Versace" and "Fight Night," Migos really hit their stride with "Bad and Boujee," which went on to peak at number one on the U.S. Billboard Hot 100 last week. The group became largely known in 2013 for their "Versace flow"—rapping in taut triplets—which influenced the likes of Drake, Future, and even Kanye West. Although they didn't invent triplet flow, their usurpation of the technique became the cornerstone of their sound, members Quavo, Offset, and Takeoff's burst-fire delivery tap dancing atop trap hi-hat percussion and chilly synthesizers. It's perfectly acceptable that Culture makes no attempt to sound wildly different than its contemporaries, because it's ultimately a satisfying affirmation that Migos has fully mastered its musical lexicon.
Top 10 Singles of 2016
Repeat to yourself: My music will get me through the next four years. My music will get me through the next four years. My music will get me through the next four years. Here are ten great songs from last year. Maybe one of them will get you through the next four years.
Top 25 Albums of 2016
If music is as therapeutic to me as it is to everyone else, then 2016 gave music a new level of importance in all of our lives. It was a bad year, but at least we got some great albums out of it. Here are my favorite albums of 2016.


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[Auction] Ring of Sexiness: Stealth +15, Dex 8, SI 4, MR 3, EP 25, HCI 15, DCI 15, SDI 15, DI 25, Poison 15!!
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Financial Controller
- Recruiter
- Hays Specialist Recruitment Limited
- Location
- Durham, County Durham
- Salary
- £50,000
- Posted
- 21 Apr 2017
- Closes
- 24 Apr 2017
- Sector
- Manufacturing
Manufacturing, SME, Systems and Processes, Staff Management , Qualified Accountant, £50,000 - £55,000 Well established manufacturing and distribution business based in County Durham have a permanent vacancy for a professionally qualified Financial Controller to join their Senior Management team leading a team of Accounts Assistants.The position reports directly in to the Managing Director of the business, and will take full responsibility for all aspects of management and financial accounting duties, the provision of management information to support business strategy and growth, as well as looking at financial processes and procedures alongside financial systems to improve and develop these further.The role requires you to roll up your sleeves and get involved in day to day financial operations, as well as playing a significant role in the Senior Management Team, reporting to the Board and ensuring robust financial processes are embedded to help drive the business forward.You will need to be proactive and driven, with a diplomatic but firm approach, exceptional engagement skills and be able to deliver the detail whilst focusing on the bigger picture. As a confident and capable communicator, you will have proven skills in cashflow management, preparing budgets, forecasting and IT systems.This is an excellent opportunity to join a business where you can really make a difference in shaping the financial future of an organisation.Friendly and capable team, and a commitment to work life balance add to the attraction of this role.What you need to do nowIf you're interested in this role, and feel you have the experience to succeed, click 'apply now' to forward an up-to-date copy of your CV, or call us now.If this job isn't quite right for you but you are looking for a new position, please contact us for a confidential discussion on your career. Hays Specialist Recruitment Limited acts as an employment agency for permanent recruitment and employment business for the supply of temporary workers. By applying for this job you accept the T&C's, Privacy Policy and Disclaimers which can be found at hays.co.uk


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Joomla to WordPress website conversion for Hyperacusis Research
We converted a Joomla site to WordPress to ensure a consistent look and feel, mobile readiness, and to make editing site content much easier.
We converted a Joomla site to WordPress to ensure a consistent look and feel, mobile readiness, and to make editing site content much easier.
Essential tips on how to defend your website against the incessant attempts to break into it. Number one: make sure your website software is up to date.
Tips on how to block IP ranges from your Google Analytics statistics. Useful for companies with multiple locations. Keep staff visits from skewing results.
Brand new WordPress website and online presence for upstate NY medical biller Medetec. Responsive, SEO, Facebook, Twitter and more.
Schenectady financial planner Bill Del-Sette helps people to be happy in retirement. We made him happy with his new responsive WordPress website.
We discuss essential tips on how to create and manage an effective online presence. We were interviewed by Dylan Hall of Schenectady's Light the City initiative.
Podcast: Play in new window | Download
Sign up for our monthly newsletter of online communications tips today and receive a FREE list of terrific cloud services to save you time and money.
Your email is safe with us. We do not spam or share our list with anyone. Ever. And you can unsubscribe from our list any time you like.


text: Handwritten Burmese text {{Infobox }} Contents[show] Phonology Edit Grammar Edit Orthography Edit Common difficulties Edit Resources Edit Retrieved from "http://learnanylanguage.wikia.com/wiki/Burmese_(article)?oldid=5715" Ad blocker interference detected! Wikia is a free-to-use site that makes money from advertising. We have a modified experience for viewers using ad blockers Wikia is not accessible if you've made further modifications. Remove the custom ad blocker rule(s) and the page will load as expected. Categories: Languages Alphabet-written languages Burmese script Add category Cancel Save


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News articles
Ten years as a foundation trust
Moorfields celebrated 10 years as a foundation trust in April 2014.
Focusing on you: welcome to Moorfields at Croydon
Moorfields will be providing all eye care services at Croydon University Hospital and Purley War Memorial Hospital from Tuesday 1 April.
Moorfields consultants open up eye debate in Asia
Moorfields consultants are taking a leading role at the first Ophthalmology Futures Asian Forum in Japan next week.
Moorfields staff celebrate Healthcare Science Week
Don't rule out science technology and engineering as a career say Moorfields healthcare scientists.
New qualification in clinical ophthalmic practice
Recruitment is now open for the first blended learning postgraduate programme for nurses and health professionals in ophthalmology.
Moorfields and UCL join the fight against avoidable blindness
Moorfields Eye Hospital and UCL join forces with The Queen Elizabeth Diamond Jubilee Trust in the fight against avoidable blindness.
Moorfields supports World Glaucoma Week 2014
Moorfields is backing the World Glaucoma Association's Beat Invisible Glaucoma campaign for World Glaucoma Week 2014.
Our new website
We hope you like our new website. Please let us have any commments or suggestions for future improvements.


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The FlashBrainer's integrated 4-Stage Accelerated Innovation® Process helps you generate, plan and organize ideas. The tool also helps you use your whole brain to generate up to 530% more ideas than traditional brainstorming.
The FlashBrainer® is software that actually helps you think better, faster and smarter — using hundreds of proven questions, words, quotes and images as inspiration. Do you want to BE more creative? Do you want to KNOW how to innovate faster? Read on to learn how we can help.
The software has 180 color-coded 'cards' that use a proven innovation language. Many people find the FlashBrainer tool is more valuable than traditional books or software on innovation.180 color-coded cards guide you through the 4 stages of our unique Accelerated Innovation process to help you think differently.
How does the FlashBrainer work? [ back to top ]
The FlashBrainer works because it is designed to help you use your whole brain. Your brain is much more complex than traditional right and left brain models. Your brain actually has 4 quadrants and the FlashBrainer stimulates all 4 of them which inspire you to quickly develop innovative solutions. The FlashBrainer uses carefully-researched stimulus to provoke your brain to be more creative and innovative. The tool's innovation language is based on the biological structure of the human brain and Gerald "Solutionman" Haman's 4-quadrant 4Brain Thinkers™ Model.
Now, let's try a little FlashBraining!
I've chosen some sample words and questions from the 180 "cards" in the FlashBrainer to demonstrate. First, think of a goal, challenge or problem… Record your responses as you work through the steps below.
Every good solution begins with a solid understanding of the problem.
Begin expanding your mind by generating a broad array of different ideas. Get ready to record your answers, and select a prompt on the right to get started.
Ask Yourself:
What is needed, wanted or wished?
- Motivations
- Facts
- Perceptions
What If You:
- Define
- Redefine
- Discover
Think About:
"It isn't that they can't see the solution; it is that they can't see the problem."
- G.K. Chesterton
Sink your teeth in. Generate as many ideas as you can, there's no wrong answer (yet).
Use the Create State to begin synthesizing fresh ideas. Follow the shape of the diamonds – generate plenty of ideas, and select the best to refine in the next stage.
Ask Yourself:
What is impossible to do today, but if it could be done, would change the situation?
- Options
- Possibilities
- Emotions
What If You:
- Synthesize
- Recycle
Think About:
"Creation comes before distribution – or there will be nothing to distribute."
- Ayn Rand
Use the FlashBrainer's proven prompts to crosscheck your ideas for feasability.
The prompts in the Evaluate Stage are tuned to allow you to dissect your ideas from all angles. Identify what makes a solution the best fit for your goal or challenge.
Ask Yourself:
What are the potential evaluation criteria?
- Strengths
- Opportunities
- Threats
What If You:
- Rank
- Rate
- Prioritize
Think About:
"Objections are expressions of interest."
- Zig Ziglar
Confident you've now covered all angles, put the best into action in the final stage.
The Activate Stage ensures that your inspiration gets the attention it needs. Now that you know which ideas are best, know how to best make them reality.
Ask Yourself:
What are potential obstacles or challenges, and how must they be overcome?
- Communities
- Relationships
- Budgets
What If You:
- Implement
- Realize
- Inspire
Think About:
"An ounce of action is worth a ton of theory."
- G.K. Chesterton
It's time to step away from the drawing board and put your grand plans into action.
Craving more? Feel free to use this demo as many times as you'd like, but for the full experience, you need your own KnowBrainer!
Who uses the FlashBrainer? [ back to top ]
Everyone Who Wants To Innovate Better, Faster & Smarter.
The FlashBrainer was designed to be used by anyone for almost any purpose. It is based on how most human brains think, and therefore can be used in a variety of job situations, functions, professions and age groups. The FlashBrainer has been used by people in management, sales, marketing, public relations, communications, product and service development, finance and operations. Students and professors at several prominent universities and schools have found the FlashBrainer to be extremely valuable. Many people have used the FlashBrainer to prepare for entrepreneurial opportunities, change careers or find a new job.
How Will the FlashBrainer Help You?
Create Breakthrough Ideas Everywhere, Everytime with Everybody. The tool has helped thousands of people generate millions of ideas… and it can help YOU. People have used the FlashBrainer tool to invent award-winning products or services.
Thousands of people have used the FlashBrainer to develop, sell, market and promote ideas. If you need to save time or gain time, then the FlashBrainer is for you, your team, or your customers. If you need to increase profits or communicate more value, the FlashBrainer is for you.
Numerous ways to innovate
- 4-Step Innovation Process
- Investigate Needs
- Create Ideas
- Evaluate Solutions
- Activate Plans
- 4 Key Colors
- Blue to "Investigate"
- Yellow to "Create"
- Green to "Evaluate"
- Red to "Activate"
- 6 Types of Stimulus in Each Step
- iMusic
- Questions
- Nouns (What Words)
- Verbs (How Words)
- Quotes
- Images
- Unlimited Ways to Record Ideas
- Microsoft Word, Excel or PowerPoint
- Blank Paper, Flip Charts
- Audio, Video
- Outline, Draw, Illustrate, Sketch, Mind Map
- 4 Ways to View the FlashBrainer
- Small image
- Full screen
- Multiple views
- Project to groups on large monitors, TVs or screens
- 3 Methods of Navigation
- Manual
- Automatic
- Logical
- Random
Invest in your FlashBrainer Tool today.
Start brainstorming faster and smarter wherever you go.
Many people have used the FlashBrainer to plan meetings & events. Others have used to tool to develop plans that help people implement and execute ideas. Professors and teachers have used the FlashBrainer to teach students how to be more creative and innovative, in fact, it's been used as a "textbook replacement" for a graduate level innovation course at Northwestern University.
Many FlashBrainer users have found it to be valuable to attend webinars and workshops that help them learn the full power of the FlashBrainer and learn over 50 innovation techniques that use the FlashBrainer. All FlashBrainer owners can download a FREE eBook that provides detailed instructions on the 5 most popular techniques including FlashThinking, Questionating, Wordating, Quotemplating and Visualating.
iKnowBrainer Mobile Apps
We compressed all the great prompts from FlashBrainer into a handy interface that you can use wherever your mobile device takes you. Now on the count of three, put down the angry birds.
iKnowBrainer is now available for iPhone, Android, Blackberry, and Windows Mobile DevicesDigital products are excluded from the ROI GuaranteeBuy Now
KnowBrainer Classic Flashcard Deck
Our original set of 180 inspiring Flashcards. KnowBrainer is a hand-held brainstorming tool that expands your imagination using proven prompts, quotes, and images. It distills SolutionPeople's 4-Brain Accelerated Innovation method into a concise package.
Every KnowBrainer tool comes with our Return on Ideas Guarantee. If the value of the ideas generated using our tools isn´t greater than your investment, we´ll buy it back!Buy Now
FlashBrainer PC Software
FlashBrainer has all the power of the KnowBrainer Innovation Tool in a large digital format, wrapped up in our iMusic audio stimulator. Because odds are you're using a computer at this very moment.
FlashBrainer is compatible with Windows 2000, XP, ME, Vista, and Windows 7Digital products are excluded from the ROI GuaranteeBuy Now


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Welcome to the Post Adoption Resource Center (PARC) website. We are here to be a resource for families with children ages 21 years or younger who have been adopted from Michigan's foster care system, adopted in Michigan through an international adoption, adopted in Michigan through a domestic infant adoption, or placed in guardianship through Michigan's foster care system and are eligible for guardianship assistance through MDHHS adoption subsidy office. Bethany's PARCs are available to serve families who live in Regions 2, 3, and 4. The PARCs are a partnership of Bethany Christian Services and the Michigan Department of Health and Human Services.
PARC's services include:
- Adoptive Family Support
PARC offers monthly groups and activities for adoptive families, as well as quarterly training opportunities on issues related to adoption.
- Coordination of Community Services
PARC helps adoptive families identify and utilize appropriate community resources and will assist them with coordinating and applying for supportive services.
- Dissemination of Information
PARC provides daily telephone and email access for adoptive families to request information about general supportive services, and to help them connect with community resources.
- Case Management Services
PARC provides short term (6-8 weeks) adoption sensitive in-home case management to support adoptive families who are dealing with challenges. This includes developing an intervention plan designed to address the specific needs of the family.
Please explore our website. You will find adoption relevant articles and resources, a calendar of family friendly community events, as well as the upcoming PARC events in your region. Be sure to check out our quarterly newsletter designed especially for adoptive families.
The three regions served by Bethany's PARCs are:
Region 2: Alcona, Alpena, Antrim, Benzie, Charlevoix, Cheboygan, Crawford, Emmet, Grand Traverse, Iosco, Kalkaska, Leelanau, Manistee, Missaukee, Montmorency, Ogemaw, Oscoda, Otsego, Presque Isle, Roscommon, Wexford.
Region 3: Arenac, Bay, Clare, Clinton, Gladwin, Gratiot, Ionia, Isabella, Lake, Mason, Mecosta, Midland, Montcalm, Newaygo, Oceana, Osceola, Saginaw, Shiawassee.
Region 4: Allegan, Berrien, Cass, Kent, Muskegon, Ottawa, Van Buren.


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Howto install repositor.io
Installing repositor.io is easy! Just open a terminal as root and run this command:
$ \wget -O - http://get.repositor.io/ | bash
If you don't have wget installed you can also use curl for this:
$ \curl http://get.repositor.io/ | bash
This will add the EPEL and RexOps package repositories to your package manager (on CentOS and RedHat) and install the application.
Supported Distributions
The installer script of repositor.io is tested on the following distributions.
- CentOS 6 + 7
- Debian 7 + 8
- Ubuntu 12.04 + 14.04


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Calistoga Winter In The Wineries
The Calistoga Chamber of Commerce and Visitor Bureau has announced the dates of its seventh Winter in the Wineries Passport Series, beginning Saturday, Dec. 3, 2016, and running through Sunday, Feb. 5, 2017. Passport holders will delight in swirls and sips in celebration of Winter in the Wineries, the leading upvalley event in the storybook city of Calistoga. Passports will be available to order in October via VisitCalistoga.com or by calling 707-942-6333. The passport price of $50 includes wine-tastings at 15 Calistoga boutique and well-known wineries and discounts on lodging and shopping at the top of Napa Valley. Winter in the Wineries Passport Series is valued at an estimated $300 and considered the best value of tasting in Napa Valley.
Visit Website


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Saga Drilling advances the zero mindset
Saga Drilling's objective is to plan and execute all our activities in such a way that we avoid accidents to personnel, environment, our assets and to our reputation. Avoiding work related illnesses for our personnel and contractors and assuring technical integrity of all assets under our management is key to our success. Our management system will assure Saga Drilling's compliance with regulatory and Clients' requirements.
We will achieve these objectives by integrating HSEQ considerations into all company activity plans and execution. Such HSEQ considerations will count equal to operational considerations. We will always be acting responsibly and treating our personnel and contractors fairly in line with our CSR commitments.
The Company managements view is that all accidents are preventable. Fostering such a mindset is an important factor that will help Saga Drilling and its stakeholders achieving their goals. Working closely together, sharing knowledge and experience, and being accountable are essential success factors.


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TRSL & Social Security
Are you eligible for Social Security benefits? If so, you'll want to attend this workshop. We'll go over the basics about your TRSL benefit...PLUS, we'll cover two federal laws that may offset your Social Security benefit — Government Pension Offset (GPO) and Windfall Elimination Provision (WEP).
You'll get answers to these questions (and more):


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So, I got trophies. However, I was last, lol. They're we're only 3 of us in Master's 40+. I got 3rd. There were 5 in my height class in the Open. I got 5th. It's all good though. I loved it. I knew going in that I still have so much to do and a ton to grow. I will say that all of the women in Physique were ripped and awesome looking - not me, lol. They were also ! ok nice & encouraging that I didn't even feel bad or overly embarrassed to be standing among them. Yay!
And this time I actually had abs too!
I saw Phil Heath & Branch Warren wandering about.
Sara's fiance, Barry, brought us Voodoo doughnuts for afterwards. Oh my goodness! My belly hurt after but it was delicious!!
My fellow physique gal & teammate & friend T-Bone!
Funny, I have 2 girlfriends nicknamed that!!


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Pittsfield, Illinois Golf Courses
Click on any the golf course listings below to explore golf courses in Pittsfield, Illinois. Find course information, driving directions, scorecards and Pittsfield, Illinois golf instructors.
Home » Golf Courses » Illinois » Pittsfield, Illinois Golf Courses
PGA of America Championships
Quail Hollow Club
Charlotte, North Carolina
Le Golf National
Guyancourt, France
Olympia Fields Country Club
Olympia Fields, Illinois
Trump National Golf Club
Washington, D.C.


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How to Scale Textures and Use Shade Maps
Learn how to adjust the scale of textures to create the look you want using a graphics program to unlock the potential of your sculpted furniture builds.
Working with textures in world can be quite frustrating. Not only are you greatly limited in the actual options but for many who are just starting to learn it can be completely frustrating. Trying to achieve a desired effect using a texture and a shade map combined might not create the look you are after. For this tutorial, we are using Bed Pack 19, which you can see in the picture below to get an idea of how it looks initially.
PLEASE NOTE: You MUST use a SEAMLESS texture in order to achieve the best results for this!
In this case, the blanket is what we are going to focus on texturing to achieve the desired effect. This is going to be a multi-step process that is actually quite simple. This tutorial as are all tutorials we release is based on Photoshop, however should be easy enough to convert to GIMP for those who prefer to use it.
First step is to select the texture that you want to use. For this example, I'm going to use a very bold block pattern that will make it very easy to see the differences.This texture when applied in world looks like this....
Which looks nice, but not as eye popping as I would like. To create the effect I want, I need to open the texture in my graphics program.
Now that my texture is open, I need to also open my shade map.
Please note, that by default when you just open a texture in ANY graphics program, it will automatically have a repeat or ratio of 1 x 1 which is 1 horizontal and 1 vertical.
Once the shade map is applied over my texture I get the following look.
Which looks like this in my graphics program.
As you can see, it looks much better but still not quite what I want.
Going back to the texture that we just opened, you need to select the layer, and then go to the EDIT menu and select DEFINE PATTERN. Choose a name for the pattern that you are creating that you will be able to remember. Once you do this, select OK. Next, go to the LAYER menu and select NEW FILL LAYER then select PATTERN at this point, a pop up window will appear asking you to select the layer name, opacity and mode options you want. For this example, I didn't worry about changing ANY of those. So just click OK.
On the next pop up window, you will be asked what SCALE you would like to apply. I changed the scale from 100% to 25% and then pressed OK. The result is in the picture below.
Once I save this texture and apply it in world, this is the result, which looks much nicer and has a much smaller scale!