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Polymeric scaffolds formed from synthetic or natural materials have many applications in tissue engineering and medicine, and multiple material properties need to be optimized for specific applications. Recent studies have emphasized the importance of the scaffolds' mechanical properties to support specific cellular responses in addition to considerations of biochemical interactions, material transport, immunogenicity, and other factors that determine biocompatibility. Fibrin gels formed from purified fibrinogen and thrombin, the final two reactants in the blood coagulation cascade, have long been shown to be effective in wound healing and supporting the growth of cells in vitro and in vivo. Fibrin, even without additional growth factors or other components has potential for use in neuronal wound healing in part because of its mechanical compliance that supports the growth of neurons without activation of glial proliferation. This review summarizes issues related to the use of fibrin gels in neuronal cell contexts, with an emphasis on issues of immunogenicity, and considers the potential advantages and disadvantages of fibrin prepared from non-mammalian sources.
The elastic properties of tissues and biomaterials designed to promote wound healing or regeneration in specific settings has until recently not been considered as an essential design feature. Most studies have addressed the biochemical and structural properties of scaffolds and extracellular matrices that dictate the molecular specificity of cell adhesions and the transport of soluble factors into and away from the site of repair. A series of recent studies has rejuvenated interest in studying how tissue and biomaterial stiffness influences the structure and function of cells by showing that matrix stiffness, under conditions where other factors are held constant, has a large effect on the rate of cell proliferation, specific programs of gene expression, cell motility, and the developmental fate of stem cells [1–3]. In some cases, matrix stiffness can override chemical stimuli, as illustrated by the lack of response to osteogenic growth factors when mesenchymal stem cells are plated on soft (< 1000 Pa) surfaces [4], and in other cases the nature of the adhesive ligand works in concert with substrate mechanics to direct specific processes such as the interplay between the type of integrin ligand and the substrate stiffness on the formation of actin stress fibers or the modulation of motility[5–7].
Not all cells respond similarly to matrix stiffness, and some cell types such as neutrophils seem not to respond to stiffness differences in the range that strongly affect other cell types [5]. One setting in which the elasticity of the substrate appears to have a highly specific effect is in central nervous system. The brain is among the softest human tissues, with a time-dependent shear storage modulus (or, depending on the type of rheologic measurement, Young's modulus) that varies from 1000 Pa at millisecond time scales appropriate for modeling effects of impact, to a relatively steady level near 200 Pa at time scales on the order of seconds [8, 9]. At sites of injury, where glial scarring occurs, the local stiffness can be palpably higher, but is not yet quantitatively determined, and the stiffness difference at the interface of the glial scar can act as a physical as well as a chemical barrier to neurite extension and neuronal repair in severe injuries [9, 10].
The possibility that soft materials might be partially useful in restoration of diseased CNS tissue is related to the finding that two main cell types of the CNS, neurons and astrocytes, respond in very different ways to matrix stiffness [10], and that gels of low elastic modulus differentially support the neuronal development of precursor cells [9]. Spinal cord and cortical brain neurons extend neurites and form branches more avidly on soft materials, and are the only cell type thus far documented to be inhibited from extending as the matrix becomes stiffer than the stiffness of a normal brain (<1000 Pa) [9, 11–15]. In contrast, astrocytes, like numerous other cell types, develop stress fibers, a larger spread area, and become activated on stiff surfaces [10]. This article will focus on evidence of the effects of manipulating substrate stiffness that may have utility in central nervous system and other injury settings and on the specific properties of matrices derived from non-mammalian clotting factors such as salmon fibrinogen and thrombin that have potential advantages or complementary properties compared to synthetic or human-derived materials.
Fibrin has a long and extensive record of use in wound healing including treatment of trauma to the brain and spinal cord [16, 17]. Fibrin is the normal scaffold that first forms at sites where trauma to cells initiates the cascade of reactions leading to blood clotting. Purification of the two final reactants, fibrinogen and thrombin, and administration in controlled amounts at defined locations has many clinical applications [18]. The fibrin scaffold can be supplemented with growth factors and other agents for specific settings and is simple to administer, with a straightforward injection into the affected region [19]. The reaction occurs at physiological temperature and pH, and both the rates of gelation and the mechanical properties of the polymerized gel can be controlled easily by adjusting the injection mix [20, 21].
Limitations of the use of fibrin in CNS or other injuries include the fact that fibrin is designed to degrade at a rate that depends on the production of plasmin and other proteases generated at the injured site, and in some settings such as neural regeneration, fibrin degradation proceeds too rapidly to allow neurite infiltration without the use of protease inhibitors that can have known or unanticipated negative effects. Cells of the CNS, including neurons, astrocytes, and microglia have receptors for thrombin, fibrinogen or fibrin that also have potentially negative effects on neural wound healing. Human fibrin is also optimized to polymerize at slightly below 37°C, and fails to clot at lowered temperatures that are required in some surgical settings, including CNS trauma. Additional concerns involve the potentials for infectious agents introduced by using proteins derived from pooled human or other mammalian sources. Some of these limitations can be overcome by non-mammalian coagulation proteins, such as have been purified from salmon blood [22–26]. Worldwide production of farmed salmon now exceeds a million metric tons annually. Therefore, millions of liters of blood with consistent quality are available from animals where genetics, nutrition, and environment are controlled or closely monitored.
Proteins derived from salmon or other non-mammalian tissues are likely to be safe from mammalian infectious agents due to the wide evolutionary distance between fish and humans. The low body temperature of cold water fish serves as another barrier to cross-species survival of bacteria or viruses. Prion infection is also most probable in species with similar prion proteins. Although salmon do have a normal isoform of prion protein, its structure is quite different from the mammalian protein [27] and therefore presents little risk. Also, there is no evidence of prion disease in fish, and even if farmed fish ingest mammalian prions, the infectivity is quickly cleared [28]. Prion contamination is a special concern in fibrinogen products, because mammalian fibrinogen can selectively bind the infective part of the prion protein [29].
Salmon fibrinogen and thrombin are sufficiently similar to human fibrinogen and thrombin to be interchangeable in terms of fibrin polymerization, but they differ subtly from those of the human proteins both in amino acid sequence and the nature of glycosylation [23, 24, 30]. For example, whereas salmon thrombin activates human platelets (a cell type absent in fish) the time course of platelet aggregation in vitro is slightly different, suggesting that salmon thrombin activates the major human platelet receptor, but might not fully activate other cellular targets [23]. The A-alpha chain of salmon fibrinogen is significant lower molecular weight compared to human A-alpha, and the gamma chain of zebrafish fibrinogen, the closest species to salmon that has been sequenced, lacks homology in a region of human fibrinogen that activates microglia [31] and is thought to contribute to inflammation in the CNS.
Differences between salmon and mammalian fibrin are apparent in several studies in which these scaffolds have been compared in cell culture and animal models. Mammalian neurite outgrowth in vitro is significantly less in human or bovine fibrin compared to salmon fibrin in three dimensional fibrin gels [33]. Human fibrin did not improve functional recovery in a rat model of spinal cord injury [33]. Human fibrinogen inhibits neurite outgrowth while salmon fibrin does not, possibly via outgrowth by triggering an inhibitory signal transduction pathway in neurons [34]. Human fibrinogen polymerizes slowly below 37°C but salmon fibrinogen clots normally down to 0°C [30]. Since outcomes can be improved by hypothermia after traumatic brain injury [35] and possibly spinal cord injury [36], salmon fibrin could be effective for the coagulopathy seen at low body temperature.
The same structural differences between salmon and mammalian fibrinogen and thrombin that in some context confers possible advantages to use of non-mammalian fibrin is potentially countered by the presumed higher antigenicity of salmon proteins in a mammalian host. The inflammatory response to synthetic and natural tissue adhesives is variable, depending primarily on the contact of tissue fluids around the biomaterial and the access of host blood cells. In general, host reactions following administration of biomaterials include stages of blood-material interaction, provisional matrix formation, acute inflammation, chronic inflammation, granulation tissue development, foreign body reaction, and fibrosis (fibrous capsule) development [37]. In the cascade of these events the role of the immune system is significant, but immune system activation largely depends on the immunogenicity of tissue adhesives.
Synthetic tissue adhesives, as most widely used and continuously developed, are relatively inert for the host immune system. For example, if administered intravascularly to the rats, N-butyl-2-cyanoacrylate induces only mild eosinophilic inflammation during the first day and after 7 days the tissue reaction is minimal [38]. However, small particles of cyanoacrylates can modulate immune response to external antigens as demonstrated by Simeonova et al. [39]. Currently it is believed that the adjuvant effect of synthetic materials in stimulating dendritic cells and the adaptive immune response to co-expressed (auto)antigens may be more important than was previously thought [40]. In addition, systemic inflammatory reactions and septic complications can develop, but the conditions that are needed for their development are not well known. Some of these rare reactions can be life threatening due to fulminant inflammatory reactions [41]. Delayed and recurrent chronic inflammatory and granulomatous reactions could be seen in response to some synthetic gels [42]. However, polyethylene glycol based biodegradable hydrogels used as tissue sealants do not appear to induce immediate humoral or cellular immune reactions [43, 44].
Thus in general, synthetic tissue adhesives do not necessarily strongly initiate cross-talk with hosts tissues and cells due to their relatively passive role in tissue repair. However, the immune reactions largely depend on the chemistry and physics of synthetic biomaterials surfaces which contact the host tissue. Biomaterials' surface characteristics have a significant impact on antigen presenting cells, including macrophage and dendritic cells' responses such as adhesion, apoptosis and cytokine secretion. These cells continuously sense and internalize their surroundings by pattern recognizing receptors orchestrating the immune system and inflammatory reactions towards the target tissue. As an example, alginate, which is composed of alternating mannuronic and guluronic acid residues has been shown to induce inflammatory response depending on the amount of mannuronic acid residues in the preparation [45]. Thus by controlling the alginate composition it is possible to modulate inflammatory reactions induced by sealants containing alginate. Synthetic materials like polyglycolic acid are also able to enhance immune response [40]. Unfortunately, thus far the interactions between synthetic tissue adhesives and the immune system are only superficially studied in spite of the fact that specially designed materials could stimulate the immune system to improve tissue healing [46].
Native tissue adhesives represent natural bio-compounds of the host to mimic the physiological situation and therefore their interaction with cellular and humoral factors of the immune system is more immediate. Here the immune system gets stronger direct signals for its activation. The extent of activation depends on genetic differences between donor (from where biomaterial is prepared) and host tissues. Tissue sealants prepared from the individual's tissues to be treated (autologous adhesives) are not immunogenic if their composition is not physically or chemically altered i.e. there are no neo-antigens recognized by the immune system as non-self. In a study by van Nooten et al. [47] a 2-component glue with sufficient elasticity and tensile strength was made by mixing canine autologous plasma concentrate with 7.5 % glutaraldehyde and applied to dogs. As a result, only mild inflammation with few lymphocytes and plasma cells around the glue was formed. The absence of CD4+ T lymphocytes in the infiltration was taken as evidence for the absence of antigen presentation in the tissue treated with glue [47]. Protein preparations from other individuals of the same species can acquire immunogenicity (for example due to blood group antigens contamination) whereas xenogenic biomaterials from tissues of other species are always immunogenic. The combination of allogenous and heterologous proteins in fibrinogen-coated collagen patches seems to diminish immunological reactions against the patches' components [48], but comprehensive immunological studies on these tissue adhesives are still not available.
The use of recombinant human coagulation proteins, instead of those prepared from blood with a possibility of contamination with infectious agents, seems to offer a treatment device that has no problems. However, an expectation that human recombinant protein preparations would be non-immunogenic in patients capable of synthesizing these proteins by themselves, is somewhat premature, if we take into account the possibility that these preparations may include trace amounts of ingredients originating from the expression systems used for their preparation. Also incomplete or abnormal post-translational modification or other, even minimal changes in the composition can render these preparations immunogenic [49]. Still, recombinant human thrombin is less immunogenic for clinical use than heterologous thrombin as has also been demonstrated by the comparative clinical analysis of Weaver et al. [50]. In this study no patients who underwent either a peripheral arterial bypass or arteriovenous graft procedure and received recombinant human thrombin seroconverted or had an increase in anti-thrombin antibody titer. In another study, the development of non-neutralized antibodies to recombinant human thrombin was detected in 3 out of 198 patients [32].
The most commonly used native tissue sealants are thrombin- and fibrinogen-based. Thrombin-based products are often produced from bovine plasma and fibrinogen-based hemostatic agents derived from human plasma [51]. Accordingly, the most serious immunological problems could rise if bovine thrombin based fibrin glue is used. Although tissue glues of such types have been safely and effectively used for many years in thousands of patients, a number of immunological complications have been reported. In most cases, these complications are related to the development of immune reactions against bovine thrombin preparations. Even a single administration of bovine thrombin can mount a significant immune response, as has been shown by the development of autoantibodies characteristic for the systemic autoimmunity in non-autoimmune-prone mice [52]. If the patient has a propensity to develop such antibodies or has pre-existing autoantibodies to thrombin, the administration of bovine thrombin containing glue could induce or potentiate immune reactions against autologous thrombin. In such cases serious clinical consequences from the antithrombin autoantibodies may appear. It is possible that these autoantibodies cause either thrombosis [53] or hemorrhage [54]. The pathological outcome of antithrombin antibodies likely depends on the antigenic epitope to which they react. According to recent studies, thrombin autoantibodies can be found in up to 40.9 % of patients with systemic lupus erythematosus and antiphospholipid syndrome [55]. Somewhat lower frequencies have been reported earlier [56], however thrombin may share common epitopes with prothrombin and beta2- glycoprotein I, well known autoantigens in antiphospholipid syndrome [57]. Similarly, antibodies to other bovine fibrin glue components like factor Va could arise [53], leading to the development of autoantibodies against human factor Va which would impair the systemic coagulation with serious clinical complications similar to those seen in cases of spontaneously developed autoantibodies [58].
Administration of bovine fibrin glue can also induce immediate reactions in the form of Immunoglobulin E (IgE)-mediated anaphylaxis against thrombin [59, 60]. If aprotinin of bovine origin is used in fibrin sealant to prevent lysis of the clot, anaphylactic reactions can develop [61, 62]. A specific immune response induced by local aprotinin administration does not differ from that seen in intravenous exposure [61].
The development of immune reactions to bovine fibrin glue and other glue materials of bovine origin is mostly due to the presence of xenogenic carbohydrates such as Galα1-3Gal in bovine products [63]. These carbohydrates, not present in human fibrinogen or thrombin, are strong stimulators of immune response among humans. In bovine thrombin preparations the source of Galα1-3Gal may not be thrombin itself but rather this xenoantigen can be expressed on contaminating proteins. Whatever the cause, 90 % of humans exposed to a bovine thrombin preparation develop IgG antibodies against one or more of the proteins in the preparation [53].
In contrast to tissue sealants containing constituents of bovine origin, coagulation proteins of salmon used for fibrin glue development do not express highly antigenic carbohydrate Galα1-3Gal. However IgE and IgG antibodies can be developed to fish proteins, probably induced by proteins rather than by carbohydrate residues. Among fish proteins with potency to activate IgE (i.e. immediate allergen) reactions, parvalbumin, a muscle protein, holds a special position since parvalbumins from fish are considered to be the major or sole allergens for 95 % of the patients suffering from IgE-mediated fish allergy [64]. So far parvalbumins of about 30 fish species have been characterized [65] including salmon allergen Sal s1 [66, 67]. Parvalbumins of different fish species show considerable cross-reactivity and therefore are dangerous for individuals with known fish allergy that account for about 0.1–0.3 % of the general population [65]. This salmon protein was also demonstrated to be antigenic by the use of salmon antibodies in IgG ELISA and immunoelectrophoretic methods [66]. However, since salmon thrombin and fibrinogen are prepared from salmon blood the possibility that allergen Sal s1 situating in the fish muscle would contaminate salmon fibrin glue should be minimal.
Some reactions to fish proteins may also develop through cross-reactions. Thus, pre-existing autoantibodies can react with fish thrombin and fibrinogen preparations as has been shown in previous studies [23, 24]. In these studies, as well as a later one by Laidmäe et al. [30], no assays of immune response showed any unusual antigenicity of the salmon fibrin sealant (Figure 1). Humoral immune response to salmon thrombin and fibrinogen was studied after intraperitoneal administration of salmon fibrin glue to rabbits and rats. Using an enzyme-linked immunosorbent assay and salmon thrombin and fibrinogen as antigens, only a mild increase of IgG binding to antigens was demonstrated 1–3 weeks after the first fibrin glue administration. As expected, after a second dose of salmon fibrin glue, antibodies levels were higher (Fig 1A,B). In no case was an increase in clotting times observed, demonstrating that the antibodies developed did not affect the normal coagulation process (Fig 1D). Notably, when rabbit blood samples were tested with purified rabbit fibrinogen and thrombin, no antibodies were detected showing that autoantibodies to host proteins have not been developed (Fig 1C). These results were further confirmed in immunoblot studies on 23 control and 23 experimental rats where low intensity antibody reactions to other polypeptides in thrombin and fibrinogen preparations were found [30]. As also demonstrated by other authors in association with human proteins [68], salmon fibrinogen is more immunogenic than salmon thrombin. Most importantly, however, no cross- reactivity to human factor Va was demonstrated in animals immunized with salmon thrombin. This result shows that salmon fibrin glue does not induce immune reactions that might be cross-reactive with human factor Va, which is the most problematic immunological cross-reactivity associated with the use of bovine fibrin glue [69]. Also, peripheral blood C-reactive protein levels were similar in experimental and control rats at the next day of second salmon fibrin glue challenge (Laidmäe et al., unpublished). These results show that there is no immediate inflammatory reaction in response to salmon fibrin glue application. The absence of antibody cross-reactivity between salmon and mammalian proteins is likely due to differences in glycosylation and other posttranslational modifications which are substantially different between fish and mammals.
Salmon fibrin has been tested in animal models of both hemostasis and neuronal wound healing. In two models of bleeding, purified salmon fibrinogen and thrombin preparations performed as well as commercial preparations of human proteins. Salmon fibrin dressing efficiently stopped bleeding in a rat hip penetrating injury model [70] and bandages lined with lyophilized salmon fibrinogen and thrombin controls arterial bleeding in a swine model where a 4.4 mm hole was surgically formed in the aorta [71]. Gels made from salmon fibrin were superior to human fibrin gels in supporting the growth and tubulogenesis of human umbilical vein endothelial cells in vitro [72].
In addition to its utility in hemostasis and formation of a matrix in which angiogenesis can initiate, fibrin also has advantages for repair of central and peripheral nervous system injuries in part because of it mechanical properties, which can be tuned by varying fibrinogen and thrombin concentrations. Neurons, unlike other cell types, appear to grow best on very soft materials [11, 12] and fibrin fibers are among the softest biopolymers [73–75]. One consequence of the mechanical preference of neurons is evident in Figure 2, which shows how the relative amounts of neurons and astrocytes grown from a whole cortical mouse brain preparation are altered as the elastic modulus of the salmon fibrin gel is changed from 1800 Pa to 74 Pa. The softest gels, which simulate the softness of normal brain [1,3] strongly promote growth of neurons and astrocytes, whereas stiffer gels promote astrocyte adhesion and spreading but not neuronal extension.
Formation of a soft-cell-compatible matrix is accomplished by fibrin from any source, but the suitability of this matrix for specific applications depends on many factors such as the stability of the matrix to degradative enzymes released at the site of injury and the multiple signals than can be elicited by sites within the protein filaments. For the long-term cultures needed to produce robust neurite outgrowth with minimal activation of inflammation, salmon fibrin is more effective than human or bovine thrombin to support neuronal growth in vitro [33]. In part this is because salmon fibrin is more resistant to rapid degradation in a neuronal setting, and in part perhaps because of beneficial differences in post-translational modifications or primary structure. Figure 3 shows the greater extension and more robust growth of neurites from rat brain cortices in salmon fibrin compared to human or bovine fibrin. Whereas the mechanisms that account for the greater growth of mammalian neurons in salmon fibrin are not known, preliminary studies in a rat spinal cord injury model are consistent with these in vitro findings.
The biochemical and mechanical properties of fibrin gels, characterized by a large mesh size, a low elastic modulus, and binding sites for integrins and other cellular targets are well suited to use in neuronal and other tissue engineering contexts. The effectiveness of fibrin gels in vivo cannot be inferred from its efficacy in vitro without consideration of its stability at wound sites and the immunologic response of the host to this foreign material. For proteins derived from blood or even from recombinant sources possible adverse effects from infectious agents or bacterial endotoxins are also an important consideration. Such issues have motivated studies of fibrin derived from non-mammalian source such as farmed salmon, and structural differences between salmon and mammalian fibrin might also contribute to its advantageous use in neural cell growth and repair.
This work was supported by the US National Institutes of Health through NIH-SBIR (2-R44 NS048734-03)
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


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The rand added 0.5 percent to R12.9307 to the dollar as of 3.38pm, reversing losses of as much as 1.3 percent.
At 5pm, however, the rand was bid at R12.9464 to the dollar, 3.55c softer than at the same time on Tuesday.
The ANC officials who are said to oppose Zuma's plan include deputy President Cyril Ramaphosa, secretary-general Gwede Mantashe and treasurer-general Zweli Mkhize, a person with knowledge of the matter said.
The benchmark government bonds due December 2026 rose.

subset: commoncrawl


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IMF Downgrade of U.S. and U.K. Economies Puts Investors on NoticePosted on July 26th, 2017.
The International Monetary Fund (IMF) has slashed its growth outlook for the world's No. 1 and No. 5 economies, citing political pressures and fiscal uncertainty in its evaluation of the next two years. U.S. Outlook Cut as Fiscal Stimulus Remains Elusive After a dismal first half of 2017, the U.S. economy is projected to grow just...


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The 21st century has sped up many aspects of our day-to-day lives and in the area of language learning, this is certainly the case. For those of you looking for an accelerated learning German course we have some great tips in this article.
No doubt, the best type of program is one which forces you to become interactive. With the visual and audio tools to assist you in mastering the German language, interactive courses are a great way to speed up the learning process.
Some will argue you get this in a live class situation and that's true however, we are talking the 21st century here and all things online. Learning online has eased the pressure for those who can't make a regular live class or who may be a little intimidated by this scenario.
Another benefit of learning online is you can learn at your own pace. Using accelerated learning German techniques online means no waiting a week for the next class. you are basically in control.
Accelerated German Learning Tips
First learn to speak before you strive to read and write. It is easier to speak than to read and write. The interactive CDs provide a great and fun way to learn German without it being boring. There are many interactive games that will help you progress quickly with your pronunciation, usage of verbs and vocabulary.
Although you can decide to enroll for an off line class this may not be the best approach in accelerated learning German techniques. The class may be too fast or too slow for your pace, or it may be too advanced or too basic for your stage.
Therefore, you can opt to buy an audio tape or interactive CD that you can use at home. The advantage of using tapes and CDs is that you can always repeat them if you need to, and also you can progress with your German at a pace that you are comfortable with.
There are language learning programs that are available which can help you learn German quickly. The programs may have a speech recognition application that will help you to gauge whether you are getting the pronunciations correctly.
Be – Do – Have German!
If you can get hold of "deutsch-speaking" movies, magazines, comics, books and TV shows, watch or read them as this will aid in your learning process. By watching the shows and movies, you will improve your pronunciation while books and magazines will improve your vocabulary and verb usage.
Make a good study time table and ensure that you stick to it. Your study routine should be consistent as this will help you progress much faster in a accelerated learning German program. Remember that in order to progress quickly, you have to be motivated and enthusiastic about learning the language.
Give yourself breaks if you find you are getting bored in your studies or if you do not seem to get anything. Take your lessons when your mind is fresh and you are not tired. Alertness and freshness will make you progress faster.
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Archive for the 'FEGLI claim' Category
The clear answer towards the query why payment state attorneys are required by you after any type of incident damage is the fact that attorneys would be the better to manage issues that are legal. They are lawyers who are the very best manual for anybody who's struggling with any type of fight that is legal. Whatever claim's kind is they are at fixing the puzzle proficient. Today you have to take this proven fact that we being non individuals that are legal do not comprehend a lot of regulation. In this scenario they are the best individuals to assist you to for all of US regarding everything because they may decode regulation. Sometimes the conditions that are lawful create us baffled particularly when we are through some type of an issue. They are proficient with conditions that are denied FEGLI claim lawyer as well as their skill is based on law's world.
These payment attorneys are individuals who might help you from form-filling to earning the situation together with your state. In some instances you can be advice by them without having of courtroom negotiations as well. Within this respect never any documents without them and you have to be careful. Ensure that anything is signed by you under their guidance. Along with all of this it requires to become stated that these attorneys might help you receive your state quicker. You can't handle regulation on your own why you will need the help of an attorney and that's. They execute lots of issues with respect to you and often assist you having a large amount of issues. In a nutshell they are a trusted supply to rely on.
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Between a work Google account, YouTube checker Google account, and personal Google accounts, it can be tricky to determine which account you are logged into if you have not set up Chrome profiles. You can create multiple Chrome profiles and easily switch between accounts without having to sign out of either account! Below is a screencast on creating multiple profiles (https://youtu.be/tMUSjliPhk0).
If you prefer to see a step-by-step guide, here are instructions on how to set up a second Chrome profile for the GCISD YouTube Checker account but could also be used for creating profiles for any other email account. If you would prefer a larger copy to save or view, you can access a PDF of instructions here.
If a video cannot play when logged into the YouTube checker account, you can submit a work order to have the video approved at help.gcisd.net


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Citrus Zinger Sport
Brand Zing Anything
Turn up to your next yoga class with a zing with the Citrus Zinger Sport. The convenient, leak-free bottle includes a flip-up straw for spill-free hydration on-the-go!
The Citrus Zinger is perfect for sporty activities like running, swimming, hiking and jogging as it's extremely lightweight, and features a 'no hands' straw - with justa bite you can position the straw and sip your zingy citrus infused water while on the go!
The Citrus Zinger Sport uses an active infusion technology to infuse water with citrus fruit flavors, vitamins, and nutrients. You can jazz up your lemon water by adding ingredients like cucumber or ginger to the middle section of the water bottle.
Perfect for indoor and outdoor exercise, the Citrus Zinger Sport will quickly become an essential part of your workout routine. They are so lightweight and easy to carry, and make you drink more water as you can experiment with different zingy combinations!
- Finger hole for easy carrying
- Easy to add ice via the bottom opening
- Capacity 800ml
- BPA/Halogen/EA and Phthalate-free


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Solid-phase extraction of lead and copper on a polyhydroxybutyrate-b-polydimethyl siloxane (PHB-b-PDMS) block copolymer disc and flame atomic absorption spectrometric determination of them in water and food samples
Correspondent: Fax: +90 356 2521585;
e-mail: email@example.com
A separation and preconcentration procedure based on solid-phase extraction of Cu(II) and Pb(II) as their Sudan III chelates on polyhydroxybutyrate-b-polydimethyl siloxane (PHB-b-PDMS) block copolymer disc has been established. Various analytical parameters including pH, amount of Sudan III, eluent type and volume, sample volume, flow rates were optimised. The effects of concomitant ions on the retentions of the analyte ions on PHB-b-PDMS disc were also examined. The detection limits for Cu(II) and Pb(II) were found to be 2.3 and 4.9 μgL−1, respectively. Preconcentration factor was found to be sixty. Relative standard deviation was found to be 5%. The accuracy of the method was confirmed by analysing certified reference materials (TMDA 54.4 fortified lake water and NIST 1515 Apple leaves). Optimised method was applied to determine the analyte ions in various water and food samples from Turkey.


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Simple Oyako Donburi (Oyakodon)
Recipe by howcheng
This is a very simple way to make Japanese oyako donburi. The name literally means "parent and child", referring to the main ingredients, chicken and egg. This version of the recipe came from a magazine put out by CLAIR, a Japanese governmental agency, and although contains a couple of specialty Japanese ingredients, these may be substituted.
Top Review by Ilovemy4kids
My daughter wanted a simple and healthy meal and this dish is perfect for what she needed. I marinated the chicken a tad longer than instructed, and I poured the marinade into the pot along with the chicken. The dish came together quickly and it was delicious. Thank you for posting.
See Discussion:1 Review
Ingredients Nutrition
- 3⁄4 lb chicken breasts or 3⁄4 lb chicken thigh
- 6 large eggs
- 1 green onion
- 2 tablespoons light soy sauce
- 2 tablespoons mirin
- 1 cup dashi
- shredded nori (optional)
Directions See How It's Made
- Finely chop the green onion.
- Cut chicken into bite-sized pieces.
- Marinate chicken in soy sauce and mirin for at least 10 minutes. If you don't have mirin, you can use sake and 1/4 tsp sugar. If you don't have sake, dry sherry can be used as well.
- In another bowl, break the eggs. Divide the yolks into halves. Stir the eggs, but do not fully blend them.
- In a saucepan, heat the dashi (substitute with chicken broth) to a boil. Add the chicken and cook quickly, stirring constantly.
- When the chicken is fully cooked, add the green onions and eggs in a circular motion. Roughly stir the mixture.
- In the traditional Japanese recipe, you would turn off the heat when the eggs are half-cooked and then place the pot on a cold wet towel (to keep the eggs from cooking any further), but they don't worry about salmonella poisoning over there, so I prefer to fully cook the eggs.
- Serve on steamed rice and garnish with nori to taste.


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*Revels North Program/Event Manager*
Revels North is looking for a positive, energetic and organized individual
to be Revels North's (RN) Part Time Program/Event Manager (PEM).
The PEM is responsible for organizing, coordinating and executing Revels
North events and programs. The PEM will provide operational program support
to the Executive and Artistic Directors and guidance to program
contractors. He or she will be an integral part in RN successfully
achieving program outcomes. The PEM must be flexible, detail oriented and
able to work well in a fast paced, dynamic environment. Experience with
theater, event planning and program management is a plus, but not necessary.
The PEM meets weekly with the RN core team at our office in White River
Junction and is at the office at least half time (10 hours a week) to work
in person with the AD and ED. The PEM needs to be present for relevant
events and mandatory meetings. This job will offer a unique level of
flexibility to the right person.
The Program Manager reports to the Executive Director.
Pay: $15 an hour. $15,600 a year.
Hours: 20 hours a week.
To apply, please send a resume and brief cover letter to
*View complete job description here.
Revels North l P.O. Box 415 l Hanover, NH 03755 l 866-556-3083 l
*Bringing Tradition to Life*


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Foreign relations of Uganda
|This article needs additional citations for verification. (December 2015) (Learn how and when to remove this template message)
|This article is part of a series on the
politics and government of
|Foreign relations
Bilateral relations[edit]
Both countries established diplomatic relations on 28 June 2013.
Ugandas relations with Israel remain uneasily strained due to the 1976 capturing of a French airliner hijacked by the Palestinian Liberation Organization in an airport in the now-famous city.
From 1961 to 1965 the two states, along with Tanzania, were united in the East African Common Services Organization, a common market with a loose federal structure.[3]
Malaysia does not yet have a high commission in Kampala,[4] while Uganda has an Embassy in Kuala Lumpur and Uganda high commission in Kuala Lumpur were also accredited to Brunei Darussalam, Indonesia, Philippines, Thailand, Vietnam, Lao PDR, Cambodia and Myanmar.[5][6]
Russia has an embassy in Kampala and Uganda has an embassy in Moscow.
South Korea[edit]
Establishment of Diplomatic Relations between the Republic of Korea (South Korea) and the Republic of Uganda is 26 March 1963.[7]
United States[edit]
Bilateral relations between the United States and Uganda have been good since Museveni assumed power, and the United States has welcomed his efforts to end human rights abuses and to pursue economic reform. Uganda is a strong supporter of the Global War on Terror. The United States is helping Uganda achieve export-led economic growth through the African Growth and Opportunity Act and provides a significant amount of development assistance. At the same time, the United States is concerned about continuing human rights problems and the pace of progress toward the establishment of genuine political pluralism.
Uganda and the Commonwealth of Nations[edit]
Uganda became independent in 1962 as a Commonwealth realm, then exactly a year later, Uganda became a Commonwealth republic.
See also[edit]
- Ministry of Foreign Affairs (Uganda)
- List of diplomatic missions in Uganda
- List of diplomatic missions of Uganda
- ^ Indian High Commission in Uganda
- ^ Uganda High Commission in India
- ^ East Africa Living Encyclopedia Kenya -- Foreign Relations
- ^ "Uganda Keen On Malaysia To Open Embassy In Kampala". Bernama. 6 August 2007. Retrieved 2 February 2014.
- ^ "High Commission of the Republic of Uganda, Kuala Lumpur, Malaysia". Uganda High Commission, Kuala Lumpur. Retrieved 2 February 2014.
- ^ "DIPLOMATIC AND CONSULAR MISSION". Ministry of Foreign Affairs, Malaysia. Retrieved 2 February 2014.
- ^ http://www.mofa.go.kr/ENG/countries/middleeast/countries/20070824/1_24477.jsp?menu=m_30_50
- This article incorporates public domain material from the Library of Congress Country Studies website http://lcweb2.loc.gov/frd/cs/.


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When Megan rocks out a bouquet picture. 🌺🌸💐#stacyhartphotography
Just you wait until you see her groom's epic reaction to seeing his bride for the first time. Cutest first look. Ever!!! #stacyhartphotography @samfos11 Hair and Makeup| @tay.glosssalondelaware
I'm currently taking the week off and relaxing with my family and a group of friends from our church in the Poconos to recharge before the fall schedule hits. It's been a blessing to have time to unwind and to fellowship together and the best part? It's only Tuesday!!! Today the girls are on kid duty as the guys go off and do a group created The Office Tour of Scranton, PA. I'm pretty sure they will make Dwight Schrute and Michael Scott so proud. Tomorrow is ladies day and we are off to a winery and some shopping. In the short amount of time I have been "off", I already feel rejuvenated. I can't wait to kick the fall season into high gear! Remember, if you want a fall family session to contact me soon. I am almost fully booked up until November, but have a few spots left. Tell me, what's your favorite to recharge?
And, I die! Russ and his olive suit, Anna and her light peachy wedding dress. I was over the moon with all the style at this wedding, and the earth tones were making my heart sing. Not to mention, their beautiful ceremony had all the right sentimental touches. Just you wait and see! ❤❤❤Yesterday I was smiling the whole day. #stacyhartphotography #olivesuit #CantTuttThis
Guess what?!? Maria and Kevin's White Clay Creek engagement session is on the blog today! Whoop! These two. Gosh, I just love them. From the first time we met, I knew they were going to be fun to work with, but I didn't want to leave this shoot. It felt like I was photographing long time friends. I had so much fun, and also it totally helps that they are just plain gorgeous and the light was absolutely perfect! I'm seriously a lucky photographer. #udelengagement http://stacyhart.com/maria-kevin-a-wilmington-de-engagement/
Film+feminine details = 💗 I swear I'll post this styled shoot soon! #stacyhartphotography #ishootfujifilm @thefindlab
This is what my dreams are made of. Photographing my sweet wedding couple from a couple years ago as they anticipate becoming a family of four! Aren't they the cutest?!? #lovemyjob
Give me all the details... #stacyhartphotography #weddingshoes #weddingdetails
Steph and Tyler's breathtaking West Chester engagement session is up on the blog today and you are going to love it! You guys, it was seriously hard to choose the images for this post because they were all my favorites. We met at a farm where Steph keeps her beautiful horse, and I couldn't get over how gorgeous this whole property was. Not to mention we had the most incredible light that evening. The whole session was swoon worthy, but that was mostly because of Steph and Tyler's playful chemistry and model skills. I just loved working with you both and am so excited for your wedding! Can't wait!
I'm kinda obsessed with the talent of @astyledfete and I love teaming up with her. Don't you just love this? Also, be sure to check out her IG page and shoe her some love. She is making a huge announcement this month that you won't want to miss . #weddingfloral #weddinginspiration #weddingfloraldesign #theknot
It's like Christmas morning every time I get film scans back from @photovisionprints #fuji400 @ishootfujifilm #ishootfujifilm #stacyhartphotography
I mean, can you feel the joy?!? #dudeandwife #hinduwedding #marriedatdeerfield


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Effective and reliable Voice Alarm (VA) systems are imperative in today's modern retail environment, where shoppers in crowded shops and centres need clear guidance in the event of an emergency to leave via the safest evacuation route. A good Public Address (PA) system allows retailers to play both pre-recorded and live promotional messages throughout stores and malls, which combines with the EN54-certified VA system that ensures shoppers are safe.
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Cases involving individuals who have been injured in crashes and collisions involving commercial airlines and private airplanes. An aviation Accident is an occurrence associated with the operation of an aircraft which takes place between the time any person boards the aircraft with the intention of flight and all such persons have disembarked, in which a person is fatally or seriously injured, the aircraft sustains damage or structural failure and/or the aircraft is missing or is completely inaccessible.
Sibley is a city in Osceola County, Iowa, United States. The population was 2,796 at the 2000 census. It is the county seat of Osceola County. It is named after Henry Hastings Sibley, a prominent General during the Dakota War of 1862, who eventually became the first territorial governor of Minnesota. William L. Harding, governor of Iowa from 1917 to 1921, was born in Sibley in 1877. Hawkeye Point, the highest point in the State of Iowa, is also nearby.
Aviation Accident Litigation Lawyers In Sibley Iowa


text: Die Schachtel is proud to present Angelo Petronella, a talented composer who has been working as a sound artist for many years, and has developed a very personal vision on the narrative qualities of acousmatics, which he pursues with millimetric precision and obsessive passion. In Sintesi da un Diario (Abstract from a Diary), he has created a rich and complex soundscape made of distant and future memories, imaginary places and countless possible stories. Read more on Last.fm


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|Bardric Returns
|Season 2, Episode 7
|Date of Events
|11th of August
|Airing Date
|13th of June 2015
| ↞Previous
| Next↠
|Additional Links
|▶ Watch Episode
|📖 Read Q&A
Story Edit
Bardric reunites with Kellan and two other murder-hobos.
Grigori, Kellan and Galahan stayed in town for 11 days, three of those spent in training. Grigori did nothing but live like a baron (cost: 16gp).
Kellan went on a shopping spree, buying fancy clothes, a saddle, horse feed, a tent, and two gifts for Elleth Salte (an intricate holy symbol of Hverra and perfume). Living comfortably he had living expenses of 22 gp.
Galahan wanted to buy a war-horse, but had second thoughts at the cost (400 gp). Meanwhile he also reflected on his Oath and what it would mean for his next battles. He also lived comfortably for 22 gp.
Bardric was away for 71 days! She tried to pursue her musical career, but had to return to adventuring. Bardric performed in taverns and earned a total of 71 gold. Deciding to live modestly and being very fiscally responsible she managed to save 3 gp of her work pay.
In Frelka's Tavern Edit
Everyone meets and plots their next adventure. Grigori never met an halfling, but after an explanation he accepted Kellan's little friend. Kellan proposes they try to clear the Starkwald of awakened plants, but Grigori and Galahan prefer to finish Captain Koke's last quest of putting to rest the specter in the Elven Ruins' tomb.
On the first day Edit
Before leaving Viriskali Kellan recalls his meeting with Elleth Salte, the awkward exchange ends in a positive note with a quick kiss.
Later in the morning Grigori leads our group to the Elven Ruins, the entrance is surrounded by some small earth mounds, including one that crumbled due to hammer blows.
The party approaches the entrance warily, Kellan senses the presence of undead and a very faint scent of dragon... Galahan sees a green foot and leg and descends the stairs which results in him being accosted by three wolves and one dire-wolf.
Galahan is surrounded at the foot of the stairs and bitten badly so he backtracks to the top. Creating a choking point the team fends off against regular wolves, while the dire-wolf stays in the back. Two wolves are roasted after oil is tossed and set on fire.
The dire-wolf is the last one standing and is now menacing Galahan. After a series of slashes, thrusts and spells there's a large howl by Kellan as the dire-wolf is slain.
Entering the tomb Edit
Galahan is bandaged by Grigori and everyone steps into the granite antechamber. A familiar room is presented, including a "dragon head" with smoke pouring out, a door to the right with a warning of: "Kuthar's bane, enter not" and a door to the left. There are gobbelin corpses, partially eaten and one dead wolf at the front dais.
Dr. Grigori posits that this presumed elven ruin, may not be elven, since its dragon head may indicate a dragon worshiping cult.
Opening the antechamber's left door Edit
Kellan notices a creature stuck in the ceiling with glinting eyes, a slug-like body and tentacles hanging above. Galahan "pokes" the creature, it falls screaming horribly to the floor.
This carrion crawler misses Galahan but hits Kellan. Fortunately his body resists the poisoned tentacles. Galahan ends it with a divine blow.
Grigori tries to clarify if Bardric is related to the dead gobbelins; she is not. Both rooms in the hallway are effectively empty (broken glass, empty chests, unused bedrolls).
Opening the antechamber's Kuthar's Bane right door Edit
Another familiar scene presents itself, a room with downwards stairs with a party of four descending. Bardric checks the alcoves and finds some copper coins and old bows and arrows interred with the corpses.
Checking a side room Galahan sees two dire-wolves with cubs. Grigori and Kellan do the old "light them on fire until they die" trick. Only the cubs die and the parents smash the door. Galahan lances both of them dead.
Inside the burial room, with cooked dire-wolf are some silver and blue electrum coins. These blue coins have an elven face in one side and on the other is a lizard. This reminds Bardric that there was an elven tribe that worshiped basilisks, making ritual hunts to catch these beasts.
Approaching a large rune-filled circle, Kellan realizes it is a circle of protection for undead, maybe even for one specific undead. Galahan steps inside the circle and a specter rises, it has the features of an elven woman without a face.
It evaporates when Dr. Grigori slings a powerful bolt. Searching the alcoves yields some silver. Galahan senses an undead creature nearby and everyone decides to rest and re-enter at full force.
At camp Grigori recalls a time where he was young and marched along with some other lads. In this dream Grigori saw a boy fall and tried to help him, for his troubles Grigori was whipped by a soldier. Grigori believes there is a moral, that helping the weak only gets you whipped and you have to take their burden.
Delving back they approach the end of the hall and see a black door with a image of a woman laying in a pedestal. Once again Galahan senses an undead nearby.
Opening this black door our prepared adventures notice a large shadow lying on the floor. This room has depictions of an elven woman running away from a many-legged lizard creature, another depictes the woman running and shooting an arrow at the beast, the last depiction has the woman being devoured by the now one-eyed lizard.
Everyone engages this over-sized shadow and with green flame, arrows and mockery it dies.
Inspecting the room they also notice a large gobbelin grasping tightly a large egg, that Kellan senses has a faint draconic aura.
Looting the room of treasure, Galahan picks up the egg, Grigori takes the elven skull from the coffin and Kellan acquires a magical bow.
Key Events Edit
- Cleared the Elven Ruins Northeast of Town, missing only the basilisk head room.
- Encountered and slayed a Carrion Crawler.
- Slayed wolves, dire-wolves and the last specter haunting the tomb.
- Grigori took an elven princess' skull from the tomb.
- Galahan retrieved a dragon egg from the tomb.
Treasure Edit
- Aarinadya: a fine heartwood bow with 3 extra strings and 14 arrows.
- Two gobblets (200gp each)
- Four gems for 210gp total
- Coin: 100 copper, 32 silver, 7 electrum
- Black dragon egg
- Total haul: 617.7 gold, a black dragon egg, and Aarinadya
Experience Edit
Total party experience: 1700 experience points. Divided by four, 425 experience points each.
Trivia Edit
|1 - 2 - 3 - 4 - 5 - 6 - 7 - 8 - 9 - 10 - 11 - 12 - 13 - 14 - 15 - 16 - 17 - 18 - 19 - 20 - 21 - 22 - 23 - 24 - 25 - 26 - 27 - 28 - 29 - 30 - 31 - 32 - 33 - 34 - 35 - 36 - 37
Pages in category "Episode 17"
The following 7 pages are in this category, out of 7 total.


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Doctor insights on:
Acute On Chronic Pancreatitis
What is acute vs chronic pancreatitis?
Temporary vs.: Permanent damage. Both are mostly due to alcohol abuse and gall stones. Acute pancreatitis may resolve without permanent damage to the organ, whereas chronic pancreatitis by definition is diagnosed when there is permanent damage to the organ. ...Read more
Chronic Pancreatitis (Definition)
Usually is described as a calcific pancreas in a patient w multiple prior acute episodes, pancreatic insufficiency, and frequently a history of alcoholism.. Pain is ...Read more
Idiopathic recurrent acute mild chronic pancreatitis CURE ?
Unknown.: Idiopathic means that we don't know why it happens. If we don't know why it happens then we cannot make any logical assumption as to how to cure it. Further information could be helpful. Are you diabetic? Are you overweight? What kind of diet do you have? You drink alcohol ever? Is there anything that you eat that seems to make it worse? Do you have high cholesterol or high triglycerides? ...Read moreSee 1 more doctor answer
What is the difference betwen acute and chronic pancreatitis ?
Differences: Acute pancreatitis starts suddenly and lasts for a relatively short period of time. This does not mean that it isn't dangerous, as it can range from mild to deadly. Chronic pancreatitis is a long-lasting infflamation of the pancreas. It often develops after a bout of acute pancreatitis. ...Read more
How long (days, weeks, months) does lipase stay elevated from onset of acute or chronic pancreatitis? Is Lipase elevated at end stage of pancreatitis?
Lipase: The lipase level is usually elevated in acute pancreatitis, and usually not in chronic pancreatitis. It will usually remain elevated as long as the acute pancreatitis remains active, and usually decreases as the pancreatitis improves. This can take weeks, but usually does not. A lot depends on what is causing the pancreatitis, in addition. Good luck. ...Read more
Can acute or chronic pancreatitis cause secondary lactose intolerance?
No: Lactase, the enzyme missing from lactose intolerant people, is normally made and present in the absorptive cells lining the inside of the intestine.The pancreas makes enzymes that are transported to and added to the stuff you are digesting.About a 4th of adults are lactose intolerant. ...Read moreSee 1 more doctor answer
Can you have acute or chronic pancreatitis without elevated lipase or amylase results in labs?
Chronic: Even in acute pancreatitis, these labs are unreliable, there is the possibility of lab error. Chronic pancreatitis is really more about scarring and injury to nearby structures rather than ongoing tissue damage, and amylase and lipase are usually normal. ...Read more
In the case of suspected active acute or chronic pancreatitis, do the doctors normally perform ERCP?
Sometimes: ERCP can be therapeutic in the management of some biliary pancreatitis, pancreatitis due to small stones, some types of sphincter of Oddi dysfunction, some cancers, and ascariasis infection. It is less important in diagnosis than it used to be due to the availablility of less invasive methods. ...Read more
How does serum glucose normally fluctuate during activie phases of acute or chronic pancreatitis? Does glucose get elevated AFTER pancreatitis ends?
Sugar: Your sugars can be very sporadic and and change upward or downward, with pancreatitis, but normally it will go up. As your pancreas is damaged, so are the cells that produce insulin and therefore your sugar my elevate. ...Read more
Can acute pancreatits turn into chronic pancreatitis?
Depends: Acute pancreatitis from gallstones generally does not turn into chronic pancreatitis. Chronic pancreatitis, associated with diabetes, chronic pain after eating, maldigestion of fats can occur after bouts of alcohol-induced acute pancreatitis;high triglyceride (>1000) panc'itis can also. Got stones? Get gb out; high tg-diet and meds. Alcohol-don't drink. Preg related?: see md for individual rx. ...Read moreSee 1 more doctor answer
What are your treatment options for acute diarrhea due to chronic pancreatitis?
Work up: Acute diarrhea needs usually work up and should not be assigned to chronic pancreatitis. Being accomplished with stool studies at least, depending upon how sick you are. ...Read more
Pancreatitis (Definition)
Pancreatitis is an inflammation or infection of the pancreas, causing abnormal secretions or leakage of the digestive enzymes ...Read more
- Talk to a doctor live online for free
- Acute vs chronic pancreatitis
- Can acute pancreatits turn into chronic pancreatitis?
- Idiopathic acute pancreatitis
- Ask a doctor a question free online
- Severe acute pancreatitis prognosis
- Acute necrotic pancreatitis
- Acute pancreatitis pancreatic cancer
- Mild acute pancreatitis treatment
- Talk to a gastroenterologist online


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We demonstrate in experiment an efficient cw four-wave mixing scheme with maximal intensity conversion efficiency up to 73% in a double-Λ system of hot rubidium atoms. Relevant theoretical analysis shows that this high conversion efficiency benefits greatly from the constructive interference between two four-wave mixing channels, characterized by two different space-dependent phases.
© 2010 Optical Society of AmericaFull Article | PDF Article
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J. Opt. Soc. Am. B 17(5) 820-826 (2000)
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A rollover is a type of vehicle accident, where a vehicle turns over on its side or roof. Such accidents have a tendency to badly injure the occupants of the vehicle, car, bus or truck involved and those around the vehicle. While many auto accidents occur because of human error, many also can be caused or worsened by defective products or inadequate safety mechanisms. Among these problems are vehicles that are prone to rollovers, especially increasingly popular sport utility vehicles, or SUVs. A number of vehicles have also been found to have roofs that cannot withstand rollover accidents, with drivers and passengers injured and killed. People who are injured in rollover accidents may be compensated for their injury, lost income, and pain and suffering.
Westphalia is a city in Osage County, Missouri, United States. The population was 320 at the 2000 census. It is part of the Jefferson City, Missouri Metropolitan Statistical Area. Westphalia is heavily influenced by the German heritage of the majority of its inhabitants. Many of the early settlers of the area came from the Westphalen area of Germany, hence the name. Many buildings are influenced by nineteenth century German architecture, and streets are labeled in both English and German. The center of population of Missouri is located in Westphalia .
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For theirs is the kingdom of Heaven
What does being poor in spirit mean to us in our 21st Century world? Our society considers a person poor if they don't have what is considered basic needs. Our spirit is what we call our inner being, our real selves. A person who is thought to be poor in spirit has no selfish intent. That individual looks to God for all his or her needs.
The world looks down on those who lack certain material belongings in their lives. A segment of society also feels a person who doesn't react with 'Type A' personality traits is not up to their standard.
God, on the other hand, looks at the heart. He doesn't look at what people have. He judges His children by what's inside them.
When we ask God to guide us through our days, and provide us with what we require, we have all of heaven willing to work for us.


text:
How to Change Search Queries Permalinks
I want to change search queries permalinks.
When I search at my blog url is like that
http://www.domain.com/search/ searched keyword
I want to change this permalink to
http://www.domain.com/unique id/search/searched keyword
Please tell me how to change this.
Thanks in Advance for help.
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3 Advantages Of Investing In Bulk Transport Bins For Your Warehousing Business
In the business of storing, handling, and shipping merchandise, the equipment that you use for transporting materials through your warehouse facility will always be an ongoing topic of concern. While pallet jacks, rolling carts, and other handling equipment are good to have on hand, consider bulk transport bins. Bulk bins come in many different varieties, from large to small and compact, which means you can easily find a style that perfectly caters to the daily needs of your business setup.
3 Signs You Needs To Replace The Rubber Seals On Your Factory's Hydraulics System
If your factory depends on hydraulics systems, you may wonder how to tell if the rubber seals are starting to deteriorate. If so, look for the following three signs that you need to replace the rubber seals on your factory's hydraulics system. Hydraulic Fluid Is Leaking Around The Seal If you see hydraulic fluid leaking around the seal, this is a definite sign that the rubber is no longer sealing correctly.
Troubleshooting An Air Compressor That Leaks Air
An air compressor that leaks air is a frustrating and potentially expensive problem. Not only does it mean that you may or may not have air when you need it, but it will also drive up the operating costs of your compressor, as it has to turn on more frequently to make up for the leak. If you would like to learn more about addressing this common problem, read on. This article will teach you how to troubleshoot a leaky air compressor.
No Tree Pests Allowed: Using Sheet Metal To Protect Your Fruit Tree
One of the challenges of growing fruit is that there are bandits, known as squirrels, rats and raccoons, that want to climb up the tree and steal all your fruit. One trick is to use sheet metal to prevent squirrels from climbing the tree. Also, by keeping squirrels out, you will be less likely to have a squirrel climb into your attic to create a nest. Measure The Diameter Of The Tree
Debunking The Biggest Myths About Owning A Septic Tank
If you have always relied on a public sewer system, there is no doubt that you will find the idea of managing your own waste a bit intimidating as a homeowner. However, with a little knowledge and a few pointers, owning a septic tank on your property is really not that big of a deal. Just make sure that you get the biggest myths and misconceptions about septic tank ownership out of the way right off the bat.
Helpful Information About Renting A Crane To Move Furniture
Are the stairs in your three story house narrow and making it difficult to move furniture on the highest floor? Rather than trying to get the furniture up the stairs, you might find it more efficient to rent a crane for the task as long as there are large windows or a balcony on the third floor. In this article, find out what you should know about renting a crane for moving furniture to the third floor of your house.
Machining Options: Choosing Between Traditional & CNC Machining
There is usually an upside and a downside to everything, which ensures good competitive prices. But this can also be confusing when you need to make a choice. The same thing goes with machining, and the following guide will help you decide which type of machining best suits your needs. And to do that you should understand some of the differences between traditional machining and CNC machining. Traditional Machining The simplest way to understand the difference between traditional and CNC machining is that traditional (or conventional) machining relies on a human machinist rather than a computer to get the job done.
The Most Popular Types Of Plastic Fabrication
Plastic fabrication is the assembly and manufacturing of plastic via a variety of methods. Plastic has advantages over other materials such as glass due to its permeable nature. It is also cost effective and durable. Here are the most popular types of plastic fabrication: Welding Similar to metal welding, plastic welding occurs when heat is used to melt two pieces or more together. Thermoplastics are often dealt with in this way, when adhesive binding is simply not an option.
5 Things To Consider When Renting A Tent For Your Event
Tent rentals for an outdoor event can be really helpful to protect guests from unexpected weather conditions and to allow guests a place to escape from the sun. However, before you reserve a tent rental, you want to be sure that you choose the right tent style and size for your event. Here are the five things you will want to consider before reserving yours: The Surface: Think about the surface that the tent is going to be placed on.
Holding A Beer Unveiling Party
If you enjoy brewing your own beer, you most likely try different flavors to enjoy when they have fermented to perfection. Beer brewing is a fun hobby that has an outcome that can be enjoyed by yourself, family and friends. Consider holding a beer unveiling party when your next batch is ready for consumption. Here are some ideas you can use to make it a fun event for all invited.
Protecting Your Vineyards: How Different Types Of Vineyard Nets Maximize Your Grape Harvest
The grapes you grow to produce your Canadian wine are precious. Each grape represents a few drops of juice that turns into a few cents' worth of fine wine. When birds and other animals start plucking and consuming your fruit, that is money lost. If you use vineyard nets, you can maximize your harvest in the following ways. High Density Polyethylene Yarns The word "yarns" here is a bit of a misnomer.
How To Prep A Saw Blade For Painting
Painting saw blades is a great way to turn a tool into a piece of art. They make excellent canvases. You can't just pick up any saw blade and begin painting, though. You need to prep the saw blade first so that the painting will look perfect and last a long time. It doesn't matter if you use an old blade or a brand new one, you will still need to do some prepping:
Diversify Your Investments With Knowledge And Hard Work - Information You Need Before A Real Estate Auction
With the world economy on the rebound, many people find themselves with access to more cash and credit flow than they may have had in many years. If you find yourself in this situation, the lure of the real estate market can be strong. Real estate auctions can seem like a tempting way to jump into the market and get your hands on inventory quickly and painlessly. Before you become too involved in the auction scene, however, it's important that you have an understanding of some of the possible pitfalls and problems.


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The importance of Vitamin D
Vitamin D deficiency is becoming a global health concern affecting about 40 percent of the world's population (77% in the USA). The health factors that follow decreased vitamin D levels call for more recognition of the harmful effects a deficiency can have on the body.
"Three years ago, the Institute of Medicine concluded that having too-low blood levels of vitamin D created a health risk, particularly as we age when fracture and fall risks increase," said Mellissa Smith, Laboratory Administrative Director at Jersey Shore Hospital.
Vitamin D helps the body absorb calcium from food, strengthening the bones. The nutrient is found naturally in fatty fish like salmon and tuna, and in small amounts in mushrooms, cheese, and egg yolks. The other natural source for Vitamin D is sunshine, which causes the body to make Vitamin D.


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|Comments & References
|x rays\ncards in envelopes are divined, two methods, envelopes marked visually or haptically\n unknown\nder hellseher\nfriedrich w. conradi-horster 1897 new era card tricks Unknown
|X Rays
|New Era Card Tricks
|an envelope mystery\nforced cards put in envelopes with punch marks, including "a variation"\n unknown 1935 mental magic with cards Unknown
|An Envelope Mystery
|Mental Magic with Cards
|larsen's psychometry presentation\nwith astrological cards, where people have marked their zodiac\nwilliam larsen 1951 psychic magic - vol. 3 William Larsen
|Larsen's Psychometry Presentation
|Psychic Magic - Vol. 3
|lecture and readings\ndoing readings in the context of pseudo psychometry, examples with different objects\nwilliam larsen 1951 psychic magic - vol. 3 William Larsen
|Lecture and Readings
|Psychic Magic - Vol. 3
|covenant\nace, 2 and 3 are shuffled and distributed amongst three spectators, performer divines who has which card\nkarl fulves 1966 the pallbearers review vol. 1-4 Karl Fulves
|The Pallbearers Review Vol. 1-4 (Vol. 1, No. 5)
|seven sinners\nspelling james bond enemies on cards, then psychometry\ntony shiels 1966 the pallbearers review vol. 1-4 Tony Shiels
|Seven Sinners
|The Pallbearers Review Vol. 1-4 (Vol. 1, No. 7)
|psychometry worldly rampant\npseudo psychometry with tarot cards\nstephen minch\npseudo-psychometry\ntheodore annemann 1974 the book of thoth Stephen Minch
|Psychometry Worldly Rampant
|The Book of Thoth
|the up-down system\nout-of-room 4 spectators seal cards in envelope, performer divines them in dark room, featuring stacking system\nkarl fulves\ncharles t. jordan\n"satan's trance" (charles jordan) 1983 after jordan Karl Fulves, Charles T. Jordan
|The Up-Down System
|After Jordan
|paroptic psychometry i\nblindfolded, performer identifies objects\nrichard osterlind 1999 dynamic mysteries Richard Osterlind
|Paroptic Psychometry I
|Dynamic Mysteries
|paroptic psychometry ii\nblindfolded, performer identifies objects, different presentation\nrichard osterlind 1999 dynamic mysteries Richard Osterlind
|Paroptic Psychometry II
|Dynamic Mysteries
|trimental\nthree chosen cards are first divined, then produced from corresponding pockets\njuan tamariz\nlouis zingone\nthe zingone spread\nlouis zingone 2000 card college - volume 4 Juan Tamariz, Louis Zingone
|Card College - Volume 4
|deck and envelopes\nstacked deck\nal baker 2003 the secret ways of al baker Al Baker
|Deck and Envelopes
|The Secret Ways of Al Baker (Issue Notebooks)
|chic thief\npseudo psychometry with drawings\njohn lovick\n"sneak thief" (larry becker, stunners, 1992) 2016 the performance pieces & divertissements of the famous handsome jack, etc. John Lovick
|Chic Thief
|The Performance Pieces & Divertissements of the Famous Handsome Jack, etc.


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Search Directory
Browse By Category
- Bridal Wear
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- Venues
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London Wedding Directory
Welcome to 'London Weddings' the local venue & supplier wedding directory for London.
We have everything to help you plan your big day, from amazing cakes, ice sculptures to string quartets, plus the best local bridal wear, dj's & chair cover companies. With plenty of venues and suppliers to choose from, our directory will help you find the best local businesses to help you make your day extra special, whatever your budget.
Featured Listings
JUST SMILE - Wedding DJ & Entertainment
Most Popular DJ Service in Wedding Industry Expert Awards 2013, 2014, 2015 & 2016
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Wedding photographer covering all of the UK.
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My Big Day Events... Make it Special with our Dancefloors, PhotoBooth and more!
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Award winning creative Photography
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Brides to be in Kent and South East London - if you and your hens like chocolate, this is the hen do for you!... https://t.co/1CloQ1FSEX
If you are looking for a venue around the Surrey area, perhaps Caper & Berry at Losely Park would be suitable... https://t.co/TJFQPh2GfC
Brides looking for a beautician - why not consider Emma Olliff....... https://t.co/wlCOZyHzjb


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After we eat dinner we go upstairs and my grandpa has the floor. You would think that our attention spans would be a lot longer as we are all older and could really sit a lot longer than when we were younger. Nope, I remember when I was younger he would talk for thirty, forty, fifty minutes maybe even an hour (maybe is felt like that long) and we would listen to him speak about Christmas and help us really get into the spirit of it all. Now he is lucky if we last fifteen minutes! Getting older hasn't made us more patient.
George and Diane
George and Diane
BEST PART ABOUT PRESENTS IS.... the cousin gift. We each get a cousin and we buy a present for them. We usually have to draw who we have on Thanksgiving, but a lot of us weren't together for Thanksgiving so some were just given names. I didn't know who had me and I was very curious because it isn't hard to guess who has you because they usually end up asking you what you want (lame I know). No one asked me, so I didn't have a clue who had my name. I guess Brittnee requested me because she had already bought my present! Right when I looked in the bag and saw the shape I knew what it was. I was a little excited not going to lie. I totally wasn't expecting it.
Why is this the best gift ever... I will show you.
Meet August.... (Matt Bomer you have some competition) who wouldn't want to look at this beautiful man for a month ( I might keep him up year round). The money from calendars goes to charity what more could you ask for! I got a present that gives to charity and I get some eye candy to look at year round.
A lot of presents had a theme the University of Utah. A lot of us are U fans!
Titan is the only baby in the family even though he would disagree that he is a baby. He is the cutest person to watch. I think he was more excited to see what everyone else got then what he got himself.
My mommy got a cute colorful watch from Kenz and I got one as well, but mine was more subtle and boring it was black. A staple in my wardrobe.
Look at the picture behind my mother. That is the last cousin pic we had done. Wow it is dreadful and needs to be taken down with something more updated!
This cute couple have been married for over a year. I had to take a picture to show the difference in wrapping techniques. Brookie bless her heart wrapped Sean's gift with baby wrapping paper and it was a little rough around the edges. Sean wrapped hers in beautiful paper that looked like perfection. So funny and such a cute couple!
I had to wrap 12 presents and it about killed me because I don't have the patience for it, but I did better than this barely! Love ya Brookie!
Some gifts that were given. My sister got some cute jewelry, Kurt whose birthday is on Christmas Eve got a thing for his car, my mommy got some pajamas and she would totally rock them. It was a gag, but I am sure they are warm and her and Kenz would have worn them! Brookie's hubby gave her footsy pajama's and she looks like WHO!!!
All my grandpa asked for Christmas was a belt. Well, he got a belt and a trip to Scotland to go golfing with my Uncle Brad!!! I was a little confused to be honest golf & Scotland don't really go together for me, but I guess it is the birthplace of golf WHO KNEW! I guess you learn something new everyday. He totally deserves it love ya grandpa!
I am kind of jealous of him because I love castles and some of the oldest castles are in Scotland, so I wish I could tag along! They can play boring golf and I could go castle browsing.... One day it will happen...
Everyone is together! Doesn't happen very often now that we are all getting older, but I enjoyed Christmas and I hopefully will see them all before next Christmas!


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We may from time to time request further information from you regarding your order. Unfortunately we have to deal with credit card fraud on a daily basis, so in the event where expensive or highly desirable goods are ordered, i.e. Apple products we may request further information - for example proof of i.d etc.
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TAMPA, Fla., June 20, 2017 /PRNewswire/ — FMVMD™, powered by Carnahan Group, and Ntracts have partnered to share their ideas on further creating efficiencies around the timely and costly compliance gaps for healthcare organizations. The end goal is to have clients […]Read More
INDIANAPOLIS, IN–(Marketwired – January 30, 2017) – Crowe Horwath LLP and Ntracts have collaborated to integrate time study data from Crowe Physician Links with Ntracts, a leading contract management system founded by Hall Render. Crowe is one of the largest […]Read More
While there are many contract management systems available today, not all truly address the entire lifecycle of contract management. Most every system has a back-end repository or contract library where you can see what contracts are expiring or who the […]Read More


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110 EATON ST, Baltimore, Maryland
$149,9002 Beds1+ BathsActive
$149,9002 Beds1+ BathsActive
110 EATON ST, Baltimore, Maryland 21224 - ANOTHER STELLAR EMPIRE HOMES PRODUCT LOCATED IN THE HEART OF HIGHLANDTOWN! FEATURING HARDWOOD FLOORING, STAINLESS STEEL APPLIANCE ALLOCATION, GRANITE COUNTERS, NEW H2O HEATER, HVAC, DRYWALL, POWDER ROOM AND BATH AND SO MUCH MORE! ONLY SECONDS FROM THE NEWER SHOPPING CENTER, PATTERSON PARK, HOPKINS, & 95. DON'T MIISS OUT ON THIS PERFECT WELL APPOINTED STARTER OR INVESTMENT HOME!
View Virtual Tour
Listing Courtesy of RE/MAX Sails Inc.
"The ups and downs of a real estate search and transaction can be daunting and draining. Having a trusted team of professionals in your corner for counsel, reinforcement, perspective, and friendship is essential in both reaching your real estate goals and also keeping your sanity during the process. They are knowledgeable about everything from financing to marketing to the local market trends and, most importantly, are a pleasure to deal with every day. They helped us navigate a few very perilous last minute developments during our purchase and never lost their cool and reasoned approach to moving forward. All in all, DC Home Buzz is a tremendous advocate for their clients. We recommend with the highest confidence."


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Innovera INKCART HP C6602A BK (IVR6602A)Item#: 40528396 | Model#: IVR6602A
- Price:
- $15.99
- Shipping:
- In Stock. Usually ships next business day. (Details)
Additional Resources
Innovera INKCART HP C6602A BK Product Details
Additional Resources: Product Manuals
Manufactured by: Innovera
Warranty provided by: Innovera
UPC No:
Mfg Part No: IVR6602A
Box Size:
( Length:0, Width:0, Depth:0)
Shipping Weight: 0.9999 pound(s)
Click here for full warranty and support information
- Innovera logos are registered trademarks of Innovera. All others trademarks and copyrights mentioned herein are the property of their respective owners.


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London Wembley Arena
...expecting to entice fresh-blood with this murk is like swapping their PlayStation for a hoop and top. ..
He ambles to the lip of the stage, still on the cusp between drag Bagpuss and unfortunate botanical experiment, ruffles his hair like a fractious child, smiles into the darkness. And immediately, like monks across a misty pasture, all your yesterdays come creeping darkly back. Your mother saying that it's all just droning. Fringe and jumper matting together in one [I]Quatermass[/I]-like entity. Interviews about Hubba Bubba, [I]Star Wars[/I], and the importance of looking like a decomposing Marilyn. These were the days before Ibiza and "tune!" replaced Elysium and doom, before industrial rage usurped pre-penicillin angst, when it was Vespasian The Teenager who lurked and tutted under badly cut hair and worse phrased poetry. Where are all the [I]fleurs du mal[/I] gone? Ah, long time passing.
Tonight, though, Robert and [a]Simon[/a] and Perry go large once more. They gave you the best worst years of their lives – the least you can do is offer up three hours as libation. It quickly transpires, however, that after all those years, your mother might have had a point. There really is a lot of droning here, pulsing with all the vital spark of a flatlining hospital monitor. [I]Eleven[/I] minutes of 'Watching Me Fall'? Her hair might be black, the bed might be white – but expecting to entice fresh-blood with this murk is like swapping their PlayStation for a hoop and top.
MPU 1 (Desktop / Tablet)
As the largely taciturn Smith strums and wanders, it's clear this is drawing to an end like a particularly long eulogy, yet for a cheap day return to the tarry pits of alienation, it's still as much fun as you can have with your cloak on. Yes, most of the material from 'Bloodflowers' stretches your attention span like perished fishnet – except, perhaps, 'There Is No If', a love song so sweet bluebirds settle on Smith's shoulder and deer gambol by – but you still happily hand over the gloom dollar for 'Shake Dog Shake', or 'One Hundred Years', for basslines like mausoleums and 'Inbetween Days', for five men for whom a summer wardrobe is an unknown concept and a dying art is not the same as death. Next week: we review the latest developments in falconry.


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About Us
The groundbreaking innovation in medical imaging and diagnostic technologies and the impact of these advances on patient care and healthcare delivery has changed the face of Medical diagnostics. Foremost amongst these, Patient safety & Care provider convenience are the tenets which Prognosys® Medical Systems has pursued, since its inception in 2004. Read More…
Service Engineer
Should have experience in X-ray, C-arms and Radiology.
Area Sales Manager
Reporting to a SBU Head, Sales Manager is responsible for exceeding sales quota within an assigned territory…


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Surgical Services
About Our Surgical Services
Ocean Medical Center has 12 operating suites, four endoscopy rooms, and three minor rooms to handle both inpatient and same day surgery requirements. Three of the operating suites are dedicated laparoscopic Ors, one is a dedicated cysto room and one room is slated for eye procedures. Our surgery procedures encompass everything from general surgery and orthopedics, to new minimally invasive techniques like Video-assisted Thorascopic surgery (VAT) and InterStim® Therapy to treat urinary incontinence.
Patients scheduled for surgery can easily complete their pre-surgical assessment utilizing One Medical Passport. Click here to get started.
Care Locations
- Ocean Medical Center, 425 Jack Martin Boulevard, Brick, NJ 08724
Find a Physician
Looking for a physician in your area? By using our Physician Directory, you can search for a New Jersey physician by specialty, facility, town, and zip code right now.
For more information on any physician, call 1-800-DOCTORS or 1-800-560-9990.


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The Sumo ST520 is at the forefront of technology Sumo Technologies announce the Sumo ST520 Industrial Flex-Mount Tablet. With a 12.1" TFT LCD display, it delivers dependable computing in harsh industrial environments.
Certified for shock and vibration protection (MIL-STD-810F), water and dust proof protection (IP65), the Sumo ST520 is provisioned for a wide spectrum of industrial deployments. Its fan-less design and high availability power (internal UPS) allows the Sumo ST520 to meet high standards for reliability, availability and durability. Operational flexibility is further enhanced with optional peripherals including GPS module, 3G wireless WAN module, 802.11 a,b,g wireless connectivity and HDD storage.
The Sumo ST520 Industrial Flex-Mount Tablet delivers robust and reliable computing in demanding operational conditions, these include:
|Dimension – 240x310x40mm / Weight – 3kg
|12.1" TFT LCD 1024 x 768 Resolution
|processor / HDD
|AMD Mobile Sempron™ 1GHz / 120GB
Supplying Tough Technology
RUGGED MOBILE Systems supply an extensive range of powerful and flexible mobile computer solutions. We can help you to improve performance in a wide range of areas using Android, Windows and iOS.
Our products include Rugged PDA's, Rugged Handheld Computers, and Rugged Tablet PC's that provide mobile solutions for industry, Government, Military, Utilities, Field Service, Emergency Services, Public Safety, Transportation and Logistics organisations worldwide.