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And so the Olympics are upon us ....
May God help us.
Since I have already gone on record with a Times Op-Ed article in April saying the games should be banned entirely because of their incontrovertible history of corruption and politicizing, I know I shouldn't watch. But given my abiding interest in the bizarre spectacle that I call SportsWorld, I won't be able to entirely ignore the endless soap operas.
I will pay close attention to the Beijing pollution index, waiting for that inevitable moment when the Chinese, with their very serious paranoia and their obsessive drive to create a perfect summer Olympiad, not only ban all cars, factory work, construction and outdoor breathing in the city, but simply move the entire population of 17.4 million temporarily to Queens. I will watch eagerly to see the amount of blue sky that actually appears over the next 16 days, because the Chinese have promised good weather, and I have full confidence in the Chinese since pretty much everything I own at this point is either made by the Chinese or will be in the near future.
I will keep an eye on the medals table, curious to see how the Russians perform now that several of their finest athletes have been suspended for failing drug tests. I will watch women's beach volleyball, not because it's a sport, but because skimpily-clad leggy women rolling in sand does put me in a state of excitement right up there with mud wrestling (no doubt the next sanctioned Olympic sport given NBC's need for strong television ratings and the correct calculus that soft-core porn under the guise of sport does have its benefits). I will watch the short-distance races to see if I can determine by naked eye alone who is cheating, because history tells us that somebody inevitably will be.
But most of all I will watch the enormously popular women's gymnastics competition. The performances are incredible and fearless, but it isn't the athleticism that draws me in. In fact I can't think of any competition in the Olympics, or all of SportsWorld, more creepy and disturbing: these largely shapeless girls in their leotards and flaxen-waxen hair and bouncy-wouncy ponytails. "They look like girls from the neck up," I was told by Joan Ryan, whose 1995 book, "Little Girls in Pretty Boxes," blew a sky-high lid off the sadomasochistic training regimens that young female gymnasts were being subjected to. She continued: "From the neck down they look like prepubescent boys."
During the Olympics, when a female gymnast finishes an event and hugs her coach, often a man three times her age, I cringe at what I believe is the unsavory stench of the sport in general — children under the wing of men who based on lengthy documentation have proven to be abusive, relentless, intolerant, humiliating and, in some instances, accused of sexual misconduct. "These girls will do anything for these guys," Ms. Ryan told me. "They have such control over them."Continue reading the main story
For the mothers and young daughters who watch in droves, Olympic female gymnasts represent the little princess fantasy, perfect pixies in those perfect ponytails. For the men who watch, they may say they do so because of the pure sport of it. But for some the voyeuristic fantasy is part of the mix as well, these older-men-little-girl relationships that remind me for some reason of the Louis Malle film "Pretty Baby" and Brooke Shield's role as a coquettish 12-year-old prostitute in New Orleans in the early 1900's.
How young are these girls? Jeré Longman and Juliet Macur of The Times recently reported that China has two gymnastics participants in the Games who may be 14, although in order to qualify, girls must have been born in 1992 or earlier. In other words, basically 16. Not that 16 is particularly old of course. It is still young, too young perhaps to compete in the Olympics where female bodies are still being formed not just physically but psychologically. But that's the way it is in women's gymnastics — in your prime in your teens until such nettlesome realities as puberty and weight gain often render you washed-up and useless. As for the coaches, the vast majority of them only care about one thing no matter how many soft and sweet hugs they give to their little princesses after an event.
Just listen to Jennifer Sey, a former national champion at 16 in 1986 whose payback to the sport before she had the sense to quit was a broken femur, a torn hamstring, several broken ankles, stress fractures in her shins and wrists and floating bone chips in one of those torn-up ankles that ultimately required surgery. There was also the obsession with keeping thin, tacitly aided and abetted by her coaches according to Sey, that led to anorexia, bulimia, a diet that consisted largely of laxatives and once caused her to soil herself in public, and the inability to menstruate until she turned 20 and had given up the sport.
"They're coaches and their only interest is in having a winning athlete," Sey told me. Which doesn't make them different from coaches the world over: no matter how many bromides they weave about character-building and lifelong lessons in discipline and the rest of the blah blah blah, winning is the only thing they care about and will ever care about, the higher the level the more maniacal the attitude.
But as Sey points out, there is one major difference between women's gymnastics and other sports — the age-level that is required to achieve the dream of making the Olympics. For a young girl who has promise, rigorous training often begins at the age of six or seven, the cycle of a regimen that quickly builds itself to as much as seven hours of practice a day. "These aren't grown children," says Ms. Sey, now 39 years old and the mother of two sons and a vice president of marketing for Levi Strauss & Co. "These are children."
That age factor, combined with the inherent physical dangers of female gymnastics, is also what causes Joan Ryan, who spent 13 years as a newspaper sports columnist in San Francisco, to call it "the must brutal sport I've ever covered."
Ms. Sey has not performed competitively since the 1980s, but the effects of what she went through still linger. It wasn't until she became pregnant at 30 that she believes she began to maintain a healthy attitude toward food, still remembering the coach who got on a loudspeaker and berated a fellow teammate for gaining a pound. To this day her hips still pop and her ankles still swell and her hands still stiffen to the extent that it is difficult to hold a cup of coffee in the morning.
But she also believes that things have changed. Girls at the elite level are not as bone-thin as they once were, in part she says, because the sport has become more difficult and demanding and therefore requires added power and muscle. Because of the age requirement that was introduced into the Olympics in 1997, girls are also obviously not as young as they once were: two members of this year's American team are 20 and the average age is roughly seventeen and a half.
Based on various medical studies, however, the sport still has a high rate of physical injury. But don't expect to see the dark side portrayed during NBC's broadcast of the games in Beijing. The sport is carefully marketed on television as an aesthetic female fantasy — girls performing death-defying feats without so much as a single blemish of what they have gone through. " But the six members of the Olympic team are the ones who have made it. What you never see, says Ms. Ryan, are "all the bodies that were broken and discarded to get to those six. There are hundreds and hundreds of bodies strewn along their path."
Julissa Gomez, a Texan who made the national team in the mid-'80's, ultimately died in 1991 from complications of paralysis after misstep on a springboard caused her to collide at full speed into the vaulting apparatus. Christy Henrich, world-class artistic gymnast, was told by a judge when she was 15 that she was too heavy to compete at an Olympic level (she was 4 feet 11 inches and 90 pounds at the time); after that, she simply withered away, weighing less than 50 pounds when she died in 1994 at the age of 22.
According to a study by Merrilee Zetaruk of the Pan Am Sports Medical Center in Canada based on data collected largely from the 1990s, the number of injuries in competitive women's gymnastics were as high as 200 per 100 gymnasts per year. There's a whole litany of injuries — skin rips on the palm from holding rings, terrible stress on the wrist in which the force was 2.37 times the weight of the body for a back handspring; spine stress fractures that affected as much as 11 percent of the female competitive population.
Dr. Zetaruk cited the phenomenon of the "female athletic triad," which in sports marked by a need for a lean body has led to serious disorders in eating, disruptions in menstrual cycle and osteoporosis. She also found that the prevalence of dangerous weight control by competitive female gymnasts, whether through use of laxatives, diuretics, excessive exercise or diet pills, was as high as 74 percent, in sharp contrast to 47 percent in female distance track athletes and 21 percent in female volleyball athletes.
There is also the dirty little secret of sexual misconduct. Nobody knows how prevalent it is. But Sey said the prevailing attitude was basically one of "see no evil, speak no evil," entirely understandable when you have young girls in the power thrall of dominant male coaches.
But there have been suspicious incidents. In 2004 in England, a top gymnastics coach named Joseph Mills was sentenced to seven years in prison after he admitted to four acts of "indecency" with girls ranging in age from eight to 14 and was described by a judge of being guilty of a "disgraceful" abuse of his position. Last December, a popular gymnastics coach named Steve Infante was charged with molesting two female gymnasts when they were in their teens. He pleaded not guilty.
But it all adds up to a sport that is far removed from any ideal of what it should be, much less the Olympic one. Former United States Olympian Dominique Moceanu, who at the age of 14 was part of the 1996 team that won the overall Olympic gold, called for the ouster of Marta Karolyi, the coordinator of the women's Olympic team, in a recent appearance on the HBO show "Real Sports."
Moceanu told me she feels the training methods of Marta Karyoli and her legendary husband, Bela, are obsolete, outdated and center on intimidation. As a result, injuries are often ignored; Moceanu suffered a lower-leg stress fracture right before the Olympics in 1996 and says Marta Karolyi initially scoffed even though she collapsed twice one day while trying to train. But seeing as Marta Karolyi has helped produce 13 gold medals for the United States at world championships since 2001, don't count on any changes, in particular if the women's team finds itself drenched in gold in Beijing.
"Why is winning the only thing that matters?" asks Sey. "There must be some national crisis of self-esteem for us to push so hard for these medals. Otherwise why would you need it?"
Because that's SportsWorld. Which is also why upon further review, I'll stick with the Beijing pollution index and the blue sky index and not watch women's gymnastics. I will no doubt miss out on some of the best performances of the entire games. But that's the trade-off when you're just not a fan of child abuse.Continue reading the main story


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"Praise the Lord," state Rep. Patricia Smith said Wednesday after Gov. Bobby Jindal signed her legislation that possibly could free some elderly inmates.
"I just didn't know what he was going to do," said Smith, D-Baton Rouge.
The governor is working his way through the hundreds of bills that made it to his desk from the two-month legislative session that ended June 23.
The latest batch of bills to get his signature includes Smith's House Bill 138 as well as legislation creating breastfeeding areas in state buildings and a crime prevention district in Broadmoor neighborhood.
Smith worked for several years to pass the proposal in HB138. The legislation makes certain offenders eligible for parole once they reach their 60th birthday.
The proposal comes with several strings. Offenders cannot be violent offenders or sex crime offenders. They must serve at least 10 years in prison, achieve the equivalency of a high school diploma and behave themselves in prison.
"What I hope it achieves is for those individuals who are incarcerated right now who have not gathered all the criteria, that it gives them hope," Smith said.
The Legislative Fiscal Office estimates the bill currently applies to 15 offenders. Freeing those 15, the office determined, could save the state $136,054 annually.
Jindal also signed Senate Bill 80 despite criticism from his office of key provisions in the measure. The legislation puts into state law the recent reorganization of the state Department of Education.
But it also requires state Senate confirmation of two additional department employees, which Jindal's office said earlier could interfere with school reform efforts.
One of the jobs is held by Erin Bendily, who is chief of department support. The other post is held by Rayne Martin, who is chief of innovation. Both are paid $140,000 per year.
The governor also signed:
House Bill 174 by state Rep. Henry Burns, R-Haughton, to allow visually impaired truck drivers to haul non-hazardous materials. The drivers would have to have at least 20/40 vision in one eye and be able to distinguish traffic signal colors.
House Bill 292 by state Rep. Jim Morris, R-Oil City, to continue a $1 driver's license fee. The money will be used for litter abatement.
House Bill 313 by state Rep. Scott Simon, R-Abita Springs, to require state buildings to provide breastfeeding and lactation stations for nursing women.
House Bill 485 by state Rep. Hunter Greene, R-Baton Rouge, to create a crime prevention and improvement district in Broadmoor subdivision. The district would be able to collect an annual fee of up to $100 per parcel.
House Bill 628 by state Rep. Walt Leger III, D-New Orleans, to allow the state's dental school and medical schools to increase tuition and fees by up to 5 percent a year for five years.
Will Sentell contributed to this report.

subset: commoncrawl


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The Rising of a "Supermoon"
By: Alan Dyer
Tags: 2013, Alan Dyer, Alberta, astrophotography, Full Moon, June 22, Moon, moonlight, Moonrise, nightscape, perigee, Supermoon
Category: Nightscape, Solar System
|Focal Length:
|1/250 sec
|Canon EOS 60D
Here is the much hyped Supermoon of 2013 rising into a twilight sky on the wet Alberta prairies.
A clear night for a change, with no storms about. Though one rolled through earlier today. We don't need any more rain! Thankfully I am high and dry on the Alberta prairie but many friends to the west are not so lucky and have been flooded out, evacuated or have been camping in their homes with power and heat off. Calgary has largely come to a standstill, with the main pastime being watching the rivers rise and fall.
Tonight, after two days of destruction from horrific floods, at least we in southern Alberta were able to enjoy a clear night and the sight of the wonderful solstice Moon rising. This is the closest Full Moon of 2013 and has received an inordinate amount of PR as the "supermoon."
It certainly did look fine tonight, though in truth no one could ever tell the difference between this "supermoon" and any normal Full Moon.
But perhaps this one is a little special, reminding us that the sky brings beauty as well as destruction.
– Alan, June 22, 2013 / © 2013 Alan Dyer
6 comments on "The Rising of a "Supermoon""
Very nice Alan. Marion & I headed North of Coronation, to get our "Supermoon" photos, when we came across an old farmhouse that looked very similar to a location you have used for some previous Time Lapse work. We pondered this for awhile, as we tried our hand at some Lunar photography. I can certainly appreciate the need for graduated ND gel filters when shooting Lunar photos. Thank You for the continued inspiration…
[…] at 6:15 on June 24, 2013 by John Klein Reblogged from The Amazing Sky: … This entry was posted in Uncategorized. Bookmark the permalink. ← […]
Alan – your images are always an inspiration for me to continue to learn about astrophotography…thank you so much!!!
These are stunning photos, Alan. Thank you so much. I saw the supermoon in the midst of fireworks tonight – Olds College 100th Anniversary. It was fantastic.


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Treatment approaches for frontotemporal lobar degeneration (FTLD) are rapidly evolving with improved understanding of the disease. This brief review highlights recent advances.
Early-onset dementia has a devastating impact on families and rids its victims of their most productive and rewarding years. Over the past ten years, FTLD has emerged as the commonest cause of dementia under the age of 60 years, outstripping even Alzheimer's disease in prevalence. Remarkable progress has occurred in our understanding of FTLD both as a set of distinctive clinical syndromes and as a set of disorders with unique genetic and pathological profiles. While there are no Food and Drug Administration approved medications for FTLD, new evidence of specific genetic and neurochemical defects are beginning to provide a strong rationale for pharmacological treatment.
Behavioral changes, which are common in behavioral variant FTD and semantic dementia, often respond to treatment with selective serotonin inhibitors. Memantine also holds promise to treat neuropsychiatric symptoms, but more prospective trials are needed. With better understanding of pathogenic molecular pathways involving microtubule associated protein tau, progranulin and TDP-43, potential disease-modifying therapies are being studied in animal models and approaching human trials.
Once considered a rare disorder, frontotemporal lobar degeneration (FTLD) is now recognized as a common cause of early-onset dementia. Patients typically present in their 50s to 60s with impairments in social comportment, language production or semantic knowledge. Because there are no Food and Drug Administration-approved medications for FTLD, treatment choices have been mostly culled from therapies that are available for Alzheimer's disease and for psychiatric disorders. In the absence of large-scale placebo-controlled clinical trials, the treatment of FTLD does not have a strong rational basis, although, with recent breakthroughs in our understanding of the biology of FTLD along with improved diagnostic accuracy, new approaches to FTLD are likely to emerge.
In 1998, Neary and colleagues established research criteria for frontotemporal lobar degeneration (FTLD) and defined three major subtypes: frontotemporal dementia (FTD), semantic dementia (SD), and progressive non-fluent aphasia (PNFA) [1]. Over the ensuing ten years of scientific progress, these research diagnoses have remained a rational underpinning for characterizing patient cohorts with unique but overlapping genetic and pathological profiles.
Frontally predominant FTD, also known as behavioral variant FTD (bvFTD) begins with atrophy of the orbitofrontal, anterior cingulate, and anterior insular cortex and quickly involves the basal ganglia [2]. Clinically, bvFTD is characterized by a cluster of behavioral symptoms in association with executive dysfunction. Typical behaviors include disinhibition, apathy, social withdrawal, loss of empathy or sympathy for others, sweet cravings, diminished insight, mental rigidity, perseverations, stereotypic behaviors, and repetitive motor behaviors [1, 3]. When delusions occur, they are often bizarre, and grandiose but rarely persecutory [4].
SD, also known as temporal variant FTD (tvFTD), begins with asymmetric atrophy of the anterior temporal lobes and anterior insulae [2] with later involvement of the orbitofrontal cortex and basal ganglia [5]. Clinically, patients with more significant left temporal atrophy present with progressive loss of semantic knowledge. Speech remains fluent but becomes empty and jargon-laden with supraordinate word substitutions (such as "food" for "carrots") and surface dyslexia. These patients have difficulty reading irregular words due to the inability to move from orthograph to meaning so that "yacht" is read as "yachtuh "or "gnat" is read as "gunat") [6*]. Multimodality agnosia leads to difficulty with object recognition. Patients with predominately right temporal atrophy may present with prosopagnosia [7] or show profound loss of emotion recognition and diminished empathy [8, 9]. Typical behavioral changes in SD include irritability, impulsiveness, bizarre alterations in dress, mental rigidity, and goal-directed compulsive collecting [10, 11]. Additionally, SD patients develop behavioral features that overlap considerably with bvFTD.
PNFA is associated with atrophy of the left inferior frontal lobe, anterior insula, and basal ganglia. Patients develop aphasia characterized by shortened phrase length, stuttering, agrammatism, and speech apraxia. Often, executive function and working memory are impaired. Most patients with PNFA ultimately develop a clinical syndrome suggestive of either corticobasal degeneration (CBD) or progressive supranuclear palsy (PSP) [12] that is confirmed at neuropathology. Behaviorally, these patients may be impulsive, apathetic, or depressed, but are generally appropriate and many have exquisitely spared insight [13*]. Both SD and PNFA are primarily language disorders, and both types of patients have been classified as subtypes of primary progressive aphasia (PPA) based upon the prominent language deficits that persist for two years with relatively spared cognition and behavior [14]. Additional motor symptoms such as Parkinsonism or motor neuron disease may accompany any of the FTD syndromes; MND most commonly occurs with bvFTD [15]. Alzheimer's disease may mimic any of the FTLD syndromes [16*], however, advances in imaging such as positron emission tomography with the amyloid ligand, Pittsburgh-B-compound (PIB-PET), AD is becoming easier to distinguish from FTLD [17].
As of January 2007, 16 open-label and randomized clinical trials had been published for patients with FTLD (for review see Boxer and Boeve [18*]); the largest study enrolled 26 patients [19]. Additional clinical trials and case reports published over the past 18 months are provided in Table 1. In 2008, Dr. Boxer began an 11-site placebo-controlled study on FTD and SD using the NMDA antagonist memantine. This six-month study will likely complete enrollment 2008 and will explore the effects of this compound on behavior and activities of daily living in these populations.
The behavioral symptoms of bvFTD and SD are often quite disturbing for caregivers and may lead to situations that are embarrassing to both caregivers and strangers. Changes in personality, commonly seen with more right-sided pathology [26, 27], and in empathy [8, 28, 29] are difficult to treat pharmacologically, and caregiver education is often crucial to maintaining family cohesiveness. Certain behavioral changes, though, such as disinhibition, inappropriate sexual behavior, dietary changes, repetitive stereotyped behaviors, and obsessive compulsive behavior, often respond to pharmacotherapy. Patients with FTLD show deficiencies in the serotonin and dopamine neurotransmitter systems, which provides rationale for the use of medications that boost these neurotransmitters [20]. The most well studied and effective treatments are selective serotonin reuptake inhibitors (SSRI), including fluoxetine, fluvoxamine, sertraline and paroxetine. A meta-analysis of SSRI and trazodone effects on behavioral symptoms in bvFTD, revealed a mean improvement in the Neuropsychiatric Inventory (NPI) [30], a measure of behavioral impairments [20]. In our practice, SSRIs (particularly ones with low anticholinergic properties such as citalopram and escitalopram) are used as first-line agents for the management of behavioral symptoms in bvFTD. The use of trazodone may be limited due to its sedating side effects. Impulsivity, which is common in patients with PSP may respond to treatment with SSRIs.
Given that memantine has a beneficial effect on the neuropsychiatric manifestations of AD [31, 32], which may be frontally mediated [31, 33], it has been speculated that memantine may also improve behavioral symptoms in FTLD. Additionally, overexcited glutamate receptors, a proposed mechanism for AD, can be hypothesized for FTLD. Over the past year, two studies reported on the use of memantine in FTLD (see table 1): a six-month open-label trial without a placebo-arm studied sixteen patients with either bvFTD or SD, all of whom received therapy [21]; and a case series followed three patients with bvFTD who each received therapy. While the larger open trial showed no improvement in behavior and a decline in cognitive function after six months, the case series demonstrated improved NPI score in all three patients after three months of treatment. Certainly, larger prospective, randomized, placebo-controlled clinical trials are needed, however, in our practice memantine is well tolerated in patients with FTLD and we offer this medication as a second-line agent for behavioral symptoms.
Atypical antipsychotic agents may be considered to treat delusions, severe agitation or aggression [22*], however, atypical antipsychotics should be used sparingly in patients with FTLD because of their sensitivity to side effects including somnolence, weight gain, extrapyramidal symptoms, and exacerbation of apathy.
Apathy, characterized by paucity of spontaneous ideation and motivation, localizes to the medial frontal lobe [5, 34], a region that is atrophied in all FTLD clinical syndromes, particularly bvFTD [5]. In general, apathy is recalcitrant to pharmacotherapyand can be a welcome relief for the caregivers in the severely disinhibited patient. In some cases, though we have tried bupropion. Bupropion has additional indirect dopaminergic agonist properties [35] and could be considered in a patient with Parkinsonism who is suspected of having low dopamine levels.
Dietary changes in bvFTD are characterized by cravings for sweets and decreased satiety, which often leads to weight gain. Later in the disease, hyperorality and oral exploratory behaviors may arise. Food cravings may be considered a component of disinhibition and has a shared anatomy (the right orbitofrontal-insular-striatal region [36]. In SD, dietary preferences may become more fastidious and even lead to weight loss, although later binge eating may occur. Dietary changes often respond in a limited degree to treatment with SSRIs [37]. Caregivers should be counseled to monitor for dysphagia and gorging behaviors, which are less responsive to pharmacologic management.
To date, no medications have been found to stabilize or improve cognitive dysfunction in any of the FTLD syndromes. Given the success of acetylcholinesterase inhibitorsin Alzheimer's disease, these medications have been tried in patients with FTLD; however, no studies have demonstrated a cholinergic deficit in any of the FTLD syndromes. Similarly, donepezil was actually found to worsen behavioral symptoms in patients with bvFTD [38], and for these reasons we have discouraged their use in FTLD. Conversely, in patients suspected of having frontal variant AD (e.g., those with positive PIB-PET imaging), a trial of acetycholinesterase inhibitors is warranted. In patients with PNFA, speech therapy may offer modest benefit, particularly early in the course of disease.
Quite often symptoms of apathy are misperceived as depression. While depression is rare in bvFTD, it is more common in patients SD and PNFA [13*]. Often patients with bvFTD are euthymic or even euphoric. While no studies are available on antidepressant efficacy in PNFA, we generally treat depression with either an SSRI, or bupropion when additional Parkinsonism is present.
Sleep disturbances occur more commonly in SD than bvFTD [5]. Once more conservative measures have been tried, trazodone should be considered for insomnia. Trazodone may have dual benefits because it was also shown to be effective for the behavioral symptoms of bvFTD in a randomized placebo-controlled trial [19]. Parasomnias such as REM sleep behavior disorder or periodic limb movements of sleep are rare in FTLD syndromes and should raise the suspicion for alpha-synuclein disorders such as dementia with Lewy bodies, Parkinson's disease dementia or multi-system atrophy. As with the evaluation of any patient with dementia, patients with FTLD should be asked about symptoms of obstructive sleep apnea (OSA) such as snoring, apneic spells and daytime sleepiness, a syndrome that may emerge due to the weight-gain associated with FTD. Patients who are obese, as commonly occurs in bvFTD, are at risk for develop OSA and treatment of such a condition may dramatically improve their cognitive function. If suspected, a formal sleep study and continuous positive airway pressure trial should be obtained.
Motor impairments, including atypical parkinsonism or weakness from motor neuron involvement, are commonly observed with more advanced disease [39], When parkinsonism occurs early in the coarse of the disease, as happens in patients with PNFA, a trial of dopamine agonist therapy should be considered. Generally, axial instability and dysphagia are recalcitrant to such treatment, but patients may experience more fluidity of movements. Lowering of blood pressure, worsening of psychotic symptoms, and constipation are potential side effects. In patients on high-dose dopamine therapy, prophylaxis against constipation with use of a stool softener should be provided. Given the gait instability that often accompanies PSP and CBD, early intervention with a physical and occupational therapist including a home safety evaluation is important. While we encourage exercise in all dementia patients, those with Parkinsonism may especially benefit from cardiovascular and weight-bearing exercise as a protective measure against further motor decline. Because all of the FTLD syndromes are associated with early-involvement of the basal ganglia or motor neurons, any patient with FTLD should be evaluated thoroughly for signs of motor neuron disease, and when appropriate, referred to a neuromuscular specialist. Patients with FTD-MND are often started on riluzole, which is generally well tolerated and has low drug-drug interactions with antidepressants and memantine.
Incontinence tends to occur earlier in FTLD-spectrum patients than in AD as the medial frontal cortex is an early target of the FTLD-related disorders, particularly bvFTD and CBD. Additionally, in PSP involvement of pyramidal tracts and Onuf's nucleus can lead to incontinence of bowel and bladder [40]. In such cases management may include intermittent catheterization or use of diapers. If suspected, these patients should be referred to a urologist for urodynamic testing. FTLD-spectrum patients, particularly those with predominantly pyramidal involvement, may respond to peripherally acting anticholinergic medications, although these medications may exacerbate confusion and exacerbate problems with lower-motor neurons. Darifenacin may have less cognitive side effects than oxybutynin or tolterodine.
Considerable progress has occurred in elucidating the genetic and neuropathological causes of FTLD and potential molecular approaches to FTLD are beginning to emerge. Approximately 10% of FTLD cases are autosomal dominant in inheritance although up to 40% show a strong family history of FTLD or related neuropsychiatric conditions [41]. In recent years, three major genes have been linked to familial FTLD: microtubule associated protein tau (MAPT) [42–45] progranulin [46, 47] and transactive response (TAR) DNA-binding protein-43 (TDP-43) [48]. Tau mutations appear to cause a toxic gain of function with abnormal aggregations of 4R tau leading to selective degeneration of neurons. In contrast, progranulin mutations, appear to cause a haploinsufficiency syndrome with decreased expression of progranulin triggering a neurodegenerative condition.
Tau and progranulin are located within 1.7 megabases on chromosome 17; however beyond their close physical proximity and role as risk factors for FTLD, the mechanism for neurodegeneration associated with each gene appears to be different. The pathological inclusions in the central nervous system associated with MAPT mutations are hyperphosphorylated insoluble aggregates of tau (FTLD-tauopathy) [42–45], whereas those associated with progranulin and TDP-43 mutations are tau-negative, ubiquitinated inclusions containing TDP-43 (FTLD-U/TDP-43) [46–48]. Only a small number of FTLD-U cases show ubiquitinated inclusions lacking TDP-43 [49, 50*]. The recent discovery that TDP-43 genetic mutations themselves are sufficient to cause neurodegeneration within the FTLD-U/TDP-43 spectrum of disease [51**] supported a pathogenic role for this protein.
Both familial and sporadic FTLD can be pathologically subdivided into FTLD-tauopathy and FTLD-U/TDP-43 types [52], and the clinical presentation may suggest which pathology is more likely. While the pathological correlate for bvFTD is evenly split between FTLD-tauopathy and FTLD-U/TDP-43 [53], most patients with SD have FTLDU/TDP-43 pathology in neurons and glia [54], PNFA (and CBD/PSP) is nearly always FTLD-tauopathy [54] with H1/H1 tau haplotype [55], and FTD-MND is associated with FTLD-U/TDP-43 [48, 53, 54].
Potential therapies for FTLD and related tauopathies are in various stages of investigation ranging from preclinical evaluation to phase III clinical trials. In a recent meeting of the Working Group on FTD Drug Discovery several of these strategies were discussed (for review see Trojanowski et al. [56**]). Table 2 provides a list of candidate drug targets.
Of the pathological proteins involved in FTLD, tau has received the most attention given the availability of powerful animal models and likely mechanistic overlap with other tauopathies, including Alzheimer's disease. Tau is primarily expressed in neuronal axons where it promotes microtubule assembly and stabilization and is involved in signaling transduction [57]. Tau mutations result in alterations of tau splicing, cleavage, and phosphorylation, any of which may alter tau function and contribute to deposition in neurons and/or glia [57]. Both toxic gain of function and loss of normal function have been proposed in tau pathogenesis, and a combination of mechanisms is likely (for comprehensive review, see Ballatore et al. [82*]). Therapeutic strategies under investigation include inhibiting tau kinases [58*–62], inhibiting/reversing tau aggregation [63], blocking tau cleavage [69], reducing tau expression [66–68], immunosuppression [70], altering chaperone systems [71], interference with splicing machinery [72], and stabilizing microtubules [74–76*]. Clinical trials for many of these compounds are already underway for Alzheimer's disease where tau pathology is always expected. Given the heterogeneity of pathology in patients with FTLD, analogous trials for FTLD should focus on patients with known tau mutations or clinical presentations usually associated with tau pathology (PNFA, CBD, and PSP).
In less than two years since the discovery of progranulin mutations linked to FTLD-U, 57 heterozygous mutations have been identified, accounting for 5 to 10% of FTLD (AD and FTD Mutation Database; www.molgen.ua.ac.be/FTDMutations) (for review see Gijselinck et al. [83*]). Progranulin is a protein growth factor expressed in a variety of body tissues [77]; in the CNS, progranulin is expressed in neurons, particularly neocortical and hippocampal pyramidal neurons, and in activated microglia [46, 84]. Progranulin mediates inflammatory response, cell growth, and cell cycle progression; when overexpressed, progranulin has been implicated in tumorogensis [85]. While full-length progranulin is anti-inflammatory, the proteolytic fragments (granulins) derived from progranulin by elastase-mediated cleavage, are proinflammatory [85]. Neurotrophic properties of progranulin have been demonstrated in neuronal cultures [78*] suggesting a role for this protein in neuronal survival. Most progranulin mutations are predicted to introduce a premature termination codon that leads to nonsense-mediated mRNA decay [83*]; this functionally null allele effectively reduces progranulin expression by 50%. Possible mechanisms whereby progranulin deficiency leads to neurodegeneration include long-term depletion of neurotrophic support and defective response to initial neuronal injury. Interestingly, the clinical phenotypes of patients with progranulin mutations are heterogeneous with some presenting in their 30s and others unaffected into their 80s [83*, 86]. Given the haploinsufficiency mechanism, progranulin is a particularly appealing gene for drug targeting because boosting its expression may be beneficial. Ribosomal read-through compounds hold promise because they may circumvent nonsense-mediated mRNA decay and result in more expression of functional protein. One such compound, PTC124, which is orally bioavailable, is already approaching phase II and III clinical trials for other genetic deficiency syndromes including Duchenne muscular dystrophy and cystic fibrosis [79, 80]. The Consortium for Frontotemporal Research (CFR), based at The University of California San Francisco, is envisioning clinical trials with read-through compounds for FTLD patients with progranulin mutations (Herz J, personal communication). The challenge will be determining how much progranulin expression levels need to be raised to have a significant clinical effect while avoiding potential adverse effects such as tumorogensis. The development of worm and mouse models will allow high throughput screening of compounds and genes that modulate progranulin expression (Farese RV and Kao AW, personal communication).
TDP-43 is an evolutionarily conserved nuclear protein that can bind to DNA and RNA, repress transcription, and initiate exon skipping [81, 87]. Its pathology is characterized by hyperphosphorylation, ubiquitination, and nucleus-to-cytoplasm translocation [48] and pathogenesis may involve both loss of normal function in the nucleus and toxic gain of function in the cytoplasm. Missense mutations are found in the ribonucleoprotein interacting domain of the TARDBP gene, suggesting a dysregulation of mRNA splicing [88*]. Mutations in either progranulin or TDP-43 are associated with TDP-43 pathology, and a cellular pathway linking the two proteins was recently discovered in cultured H4 neuroglioma cells where progranulin prevented caspase-3-mediated cleavage of TDP-43 [89*]. Caspase-cleaved TDP-43 is also a common pathological finding in AD [90*], implicating progranulin and TDP-43 in other neurodegenerative conditions and possibly broadening the therapeutic potential of progranulin/TDP-43 based therapies.
Two other causative genes for FTLD-U, valosin-containing protein VCP [91] and charged multivesicular body protein 2b (CHMP2B) [92], have been discovered in a much smaller number of families. Although rare, these mutations offer further insights into the pathogenesis of FTLD-U. VCP mutations are associated with a range of clinical phenotypes including inclusion body myopathy, Paget disease of bone and FTD [91]. VCP is a ubiquitously expressed protein involved in multiple cellular processes including endoplasmic reticulum (ER)-stress related protein degradation [93, 94]. Loss-of-function mutations in VCP are expected to cause ER stress, oxidative stress, and mitochondria-dependent apoptosis [95*]. Interestingly, patients with VCP mutations who also carry an apolipoprotein E4 (ApoE4) allele are more likely to develop FTD [96], suggesting that apoE4 is a genetic modifier for the clinical presentation of FTLD; thus apoE4 targeted therapy, which is under investigation [97] may benefit patients with FTLD. CHMP2B is involved in endosomal trafficking through the ESCRT (endosomal secretory complex required for trafficking) III complex, which may be involved in degradation of growth factors. Dysfunction of CHMP2B results in the formation of dysmorphic organelles of the late endosomal pathway and autophagosomes [92, 98, 99].
Therapeutic strategies to target TDP-43, VCP, and CHMP2B pathology will evolve with better understanding of these pathogenic mutations in Drosophila, C. elegans, and mouse models. These models will also allow for high throughput screening for genes and compounds that modify the mutant phenotypes (Farese BV, Gao F-B, and Shu H, personal communication). As with tau-based therapies, clinical trials assessing the efficacy of progranulin, TDP-43, VCP, and/or CHMP2B based therapies should focus on patients with known genetic mutations or clinical presentations usually associated with FTLD-U/TDP-43 pathology (SD and FTD-MND).
The past decade has witnessed an explosion of research in FTLD spanning bench to bedside. Large-scale, placebo-controlled clinical trials are underway to determine the efficacy of currently available treatments while optimizing measures of clinical progression. A host of strategies targeting the underlying pathology in FTLD are under investigation, and tau-based therapies are already entering phase III clinical trials for MCI and AD. The prospects for disease-modifying treatments for FTLD have never seemed closer.
This work was supported by the National Institute of Aging (P01 AG19724-01A1, P50 AG1657303-75271) and grants from the Wessinger Foundation and CFR, Dr. Miller, and a T32 and McBean Foundation Fellowship to Dr. Vossel.
Funding for this work was provided, in part, by the National Institutes of Health.
Papers of particular interest, published within the annual period of review, have been highlighted as follows:
* of special interest
** of outstanding interest
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


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Words containing emiparin
Found 1 words containing emiparin. Browse our Scrabble Word Finder, Words With Friends cheat dictionary, and WordHub word solver to find words that contain emiparin. Or use our Unscramble word solver to find your best possible play! Related: Words that end in emiparin
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- Listen to a Night of the Living Dead Rescore by UK's OGRE
- Listen to a Night of the Living Dead Rescore by UK's OGRE
- Trailer for Philip K. Dick Anthology Series ELECTRIC DREAMS!
- Noomi Rapace Plays Septuplets in SciFi Thriller WHAT HAPPENED TO MONDAY [Trailer]
- WFF 2015: NESTOR Is A Puzzle You'll Want to Watch Endlessly to Solve [Review]
- Listen to a Night of the Living Dead Rescore by UK's OGRE
- Godzilla Gets Animated in GODZILLA: PLANET OF MONSTERS [Trailer]
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- Netflix Goes PA with Alien Invasion Thriller BIRD BOX
- Godzilla Gets Animated in GODZILLA: PLANET OF MONSTERS [Trailer]
- Listen to a Night of the Living Dead Rescore by UK's OGRE
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- THE WALKING DEAD Season 8 Trailer
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Marina Antunes [Celluloid 05.25.17] thriller crime
Actor-turned-writer Taylor Sheridan made a big splash with the one-two punch of writing both Sicario and Hell or High Water which is, arguably, one of the best heist movies in a few years.
Now Sheridan is flexing his directing muscle but moving pretty far from the rather terrible horror movie he made nearly a decade ago and staying more in line with his recent fascination with crime thrillers: Wind River.
The Sundance and Cannes selected title is written and directed by Sheridan and stars Jeremy Renner as a game tracker who finds the body of a teenage girl on a Native Reservation in the far north. Elizabeth Olsen plays Jane Banner, an FBI agent sent in to investigate the homicide which appears to affect everyone in town. The movie also co-stars Graham Greene, Gil Birmingham and Hugh Dillon.
Early reviews suggest this isn't quite en par with Hell or High Water but that bar was set pretty high. The trailer suggests a fairly straightforward thriller with a unique setting which appears to play a fairly major role in the storytelling. Will that be enough to satisfy? We'll find out soon enough.
Wind River opens August 4.
Recommended Release: Hell or High Water
You might also like
uncleB (2 months ago) Reply
I like Sheridans work. I look forward to next Sicario film.
nemo (2 months ago) Reply
I had a bit of a problem with Sicario - the Emily Blunt character is set up as the protagonist, but she is just there to enable the CIA guy to be involved. So the character set up as protagonist has no role in the conclusion of the film. I'm all for breaking conventions, but that just did not work for me.
Wumpus (2 months ago) Reply
I thought her frustration with her essential powerlessness (which is basically as you described) was meant to illustrate the many frustrations of the war on drugs. *shrug* Anyway, it worked for me.


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#158 Shane Davied leads the National Points Championship as at 15th August 2017
The latest track championship charts have been published
#158 Shane Davies tops the World Rankings as of 1st July 2017
Final win for: 428 - Lee Sampson (Raymond Gunn Tribute)
Final win for: 684 - Ian McLaughlin
Final win for: 214 - Tom Yould
Final win for: 670 - Ross Watters
Final win for: 26 - Tommy Barnes
National Points are scored:Heats, Consolations, Allcomers, Last Chance Qualifiers: 10, 9, 8, 7, 6, 5, 4, 3, 2, 1Meeting Finals: 10, 9, 8, 7, 6, 5, 4, 3, 2, 1When 20 or more drivers compete in a meeting, points for the Meeting Final will be doubled.English, Scottish, ORC Championship: 30, 27, 24, 21, 18, 15, 12, 9, 6, 3British, European, National Championship: 40, 36, 32, 28, 24, 20, 16, 12, 8, 4World Championship: 50, 45, 40, 35, 30, 25, 20, 15, 10, 5
Note that "White & Yellow" grade races, not within the scope of the meeting, will not score points.
A driver's grade will be determined by his Average points, as at the end of each Grading Period.Average points are computed by dividing the total number of National Points, by the number of meetings a driver has contested.There is no exact cut-off Average points score for each grade. The number of drivers in each grade can fluctuate in relation to the number of drivers who are currently active.However, as an approximate guide:
A driver will be upgraded a maximum of two grades in one grading period.
A driver will not be eligible to be downgraded if:
Any driver in the Top 24 of the World Rankings shall have a minimum Blue grade.Former World and National Points Champions may not drop below Red grade for 4 years.Drivers shall only be downgraded a maximum of one grade per month, if they have met the criteria to be eligible to be downgraded.


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Quick review of what I think about the drawbacks of iTunes 9 are.
1. Minimizing the window to "mini player" is now a 3-button command. The green upper left button no longer functions if you think about it. Collapsing itunes to get it out of my way was the only feature I used the most. Nobody ever remembers quick commands. Those were designed for power users who were doing repetitive graphics work. I want iTunes 8 back just to get this feature back...one-click minimize to the mini player please!! WTF.
2. The interface is harder to look at. They tried to candy it up even farther, but fucked up. The pause/play button is now whiter. But the playlist background is white. This is bad because you do not want a non-object (the background) to correlate color wise with the main buttons. Its giving me a 3d headache. Poor use of dimension.
3. I don't like how ever new feature requires an iTunes account now. It seems like apple wants to know what data is on your CPU. Why would I need an iTunes account to share across a home network? Lame.
Verdict: Its just an mp3 player. Screwing up the minimize window function and making it a key-command makes me want to digg up Soundjam MP.
UPDATE. FIXED!!!!! AN UPDATE to iTunes brings back the green button maximize function.


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A Local Area Network or LAN is high speed data network that covers a relatively small geographic area such as a building, alaboratory, or a school. It connects workstations, personal computers, servers, and other devices. LAN offer computer users many advantages, including shared access to devices and applications, file exchange between connected users and communication between users via electronic mail and other applications. LANs differ in the way the computers are connected
IEEE (Institute of Electrical and Electronic Engineers) is a US publishing and standards organization responsible for many LAN standards such as the 802 series. IEEE 802.3, populary called Ethernet is the most popular LAN. Usually operating at 10 Mbps to 10 Gbps and is present in most large organizations and offices. In a typical lan configuration, one computer is designated as the server. It stores all of the software that controls the network, as wel as the software that can be shared by the computers attached to the network. Computers connected to the server are called workstations.
Two most commonlyused LAN implementations are depicted below
A) Ethernet or IEEE 802.3
B) Token Ring or IEEE802.5


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Chemical element is one of the four elements in the game.
Attack EffectsEdit
A Chemical attack can poison an opponent. This poisoning applies a Chemical buffer which inflicts damage for some turns. A Chemical attack (not the poison damages) inflicts half damage to monsters of Chemical nature and double damage to monsters of Thermal nature.
Monster ElementEdit
Monsters of Chemical nature take half damage from Chemical attacks and double damage from Electrical ones.


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Chain Link Fence Specifications
- Available heights: 3' through 16' (Special heights available on
- Fabric available in 50' rolls
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- Special fabric diameters and finishes quoted upon request
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– Aluminized 9 gauge, ASTM A491, type 1
– Fused and bonded, 9 gauge finish (10 gauge core) vinyl coated by thermally fused and bonded method per ASTM F668 specifications, class 2b
– Fused and bonded, 8 gauge finish (9 gauge core) vinyl coated by thermally fused and bonded method per ASTM F668 specifications, class 2b
Galvanized Chain Link Fence
We weave our chain link fence mesh with 9 or 10 gauge wire. Choose the gauge that best meets your needs and specifications.
Vinyl Coated Chain Link Fence
For those customers who would prefer colored chain link fencing, check out our color coordinated, vinyl coated chain link fence. This colorful fence is created by applying a generous coat of fused and bonded vinyl to rugged wire mesh. The result is chain link fencing that is bright and colorful.
And, should you like to insert privacy fence slats into the fence, the available colors of vinyl coated chain link fence closely match seven bright, attractive slat colors.
Exact representation of colors on the web is difficult. Please refer to actual color samples for accurate matching. Samples available upon request.


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Friday, December 18, 2009
Ricki's Pick of the Week: Snowman BB Gun Card from Barley & Bailey
Last month, my husband and I went to a craft fair at the high school closest to our house. We found this table full of hilarious Christmas cards by Barley & Bailey and purchased the variety pack of 24 cards (there were more there than on their website). All of the cards are great, but the Snowman BB Gun one is definitely one of my favorites. We're giving this to my father-in-law who loves the movie A Christmas Story.
Posted by Ricki at 12:19 PM
Labels: Barley and Bailey, card
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Apartment Features
- Air Conditioning
- Balcony
- Cable Ready
- Dishwasher
- Fireplace
- Gas Range
- Hardwood Flooring
- Microwave
- New/Renovated Interior
- View
- Washer & Dryer In Unit
- Garbage Disposal
- Refrigerator
Special Features
- Pets
- Short Term Available
Community Features
- Business Center
- Clubhouse
- Fitness Center
- Garage
- High Speed Internet Access
- Hot Tub
- Playground
- Public Transportation
- Swimming Pool
- Pet Friendly
- Luxury Community
Additional Features
- Pool Lounge
- Gated Entrance
- Major Employer Discount
- Barbeques
- All Size Pets
- Short Term/ Corporate Units
- Wood grain flooring with plush neutral-tone car...
- Granite kitchen counter tops
- * on Selected Units
- Ice Maker
- Cats Allowed
- Dogs and cats are permitted. No weight restrictions. $400 pet deposit per dog. $55 monthly pet rent per dog. $200 pet deposit per cat. $35 monthly pet rent per cat. Residents will be allowed a maximum of 2 pets per townhome. Breed restrictions: Dobermans, Rottweillers, German Shepherds, Dalmatians, Mastiffs (all breeds), American Bull Dogs/American Staffordshire Terriers/Bull Terriers/Pit /bulls, Wolf Dogs, and any cross breed of any of the listed breeds. Pets Accepted
- Dogs Allowed
Floor Plans & Pricing
Prices and availability subject to change without notice.
Property Details
CasaLago Eastlake
CasaLago offers three unique residence types and a host of amenities designed for relaxed and active lifestyles. Enjoy a resort-style experience with two pools with lounges and barbeques and a tranquil lake and mountain-view, and two clubhouses featuring state-of-the-art fitness center, yoga studio, plus media rooms and kitchens for social gatherings. Our luxury flats and townhomes showcase spacious two and three bedroom apartments with attached one-and two-car garages with side-by-side parking and direct access in every home. Select residences include fireplaces and private patios and terraces, grassy yards and panoramic lake views. Every home includes expansive 9' ceilings, resilient wood-grained floors, master bedrooms with walk-in closets and en suite bathrooms featuring Moen fixtures and glass shower doors. The gourmet kitchens include granite counter tops, timeless black Kenmore appliances, breakfast bars, recessed lighting and wenge wood-style cabinetry throughout.
Lease Terms
6-Month, 7-Month, 8-Month, 9-Month, 10-Month, 11-Month, 12-Month
Office Hours
Open Today
Ratings & Reviews
21 Reviews for CasaLago Eastlake
Sort by:
Thus far CasaLago has met all of our expectations. It is a beautiful and safe place to live.
CasaLago Eastlake is a clean, well-planned community with a modern feel and several resident-pleasing amenities. I am located near the pool, and enjoy the easy access to the clean and well-maintained community grills, pool, and hot tub. I frequently use all of them. The only improvement that needs to be considered is the drainage of the grassy area, near the dumpsters. During the last storm, the sidewalk was flooded and impassible.
Friendly, helpful, and efficient staff. Property is always clean and we'll maintained. From viewing the property for the first time to living here for 6 months, we don't have one single complaint.
Very nice property.
everything is close to perfection in living here at casalago. but the only problem we have is the parking. if given an assigned parking it would be excellent and perfect! some neighbors who have 2car garage still park their car outside. they would park their car outside in the morning til night. wish they would really implement towing!
What is a Certified Resident?
A resident who lives at the property and has completed a resident satisfaction survey.
Advertising properties provide a list of email addresses of its residents to Kingsley Associates, a third party market research firm, who then sends out the satisfaction survey to the residents. Properties may also conduct satisfaction surveys of its residents through other third party market research firms. In those cases, we will publish those survey responses as long as the questions conform to our standard survey format.
Because reviews are from Certified Residents, and are managed by a third party, you can feel confident that the feedback provided is accurate and trustworthy.
General Directions
From South: Take I-805N. Exit Olympic Pkwy. Turn right on Olympic Pkwy. Continue on Olympic Pkwy about 6.6 miles. Your destination will be on your right. If you reach Wueste Rd you've gone too far. * From North: Take I-805S. Exit Olympic Pkwy. Turn left on Olympic Pkwy. Continue on Olympic Pkwy about 6.6 miles. Your destination will be on your right. If you reach Wueste Rd you've gone too far.
Helpful Information
Visit the property's management website
We are dedicated to delivering exemplary service in a quality home environment. Our goal is to be the apartment home provider of choice--a goal we attain through our residents and employees. We understand that our customers define the standard of quality and service, and their loyalty must be earned.


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Tag - Canadian
What's Her Secret? Lingerie Designer Mary Young
7 Kickass Canadian Women You Should Follow on Twitter
Canadian Brands to Rock this Canada Day!
Prominent Canadian Women That Inspire Us
8 Canadian-Based Books to Read this Month
5 Fabulous Canadian Female Bloggers You Should Be...
Meet Our #29DaysofHope Winner, Doina Oncel
Q&A: Fashion Designer Kaelen Haworth
Toronto Fashion Week 2014 Kicks Off on Monday!
Alissa Mohammed Alissa Mohammed firstname.lastname@example.com Author 29Secrets
Keep posted with 29Secrets!


text: Heaven's Gate Episode 6 - Contract Void It's the final episode of Heaven's Gate! And God may have met his match. Clever Dicks Productions November 07, 2013 70 Views More Info Full Credits Clever Dicks Productions Uploader Stats & Data 1Funny2Die 70 Views November 07, 2013 Published Category Animation Sketch Web Series Tags comedy humor humour sketch skit funny simon goodway holly powis louise byrne clever dicks heaven god st peter religion satire religious satire christianity cartoon animation web series series cartoon series Up Next: Customer Service AUTOPLAY Up Next In: 10 Customer Service News and Weather Heaven's Gate Episode 1 - The God Collusion The One with the Thing that Happened Follow Browse Related Comments 9+ more View All ▶ Clever Dicks Productions Vaguely Related Videos Vaguely Related Pics & Words Advertisement Tags: comedy humor humour sketch skit Advertisement


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In the movie market of any kind of nation worldwide, Oscar is taken into consideration as one of the most distinguished rewards. Annually countless movies send their elections for this traditional competition. There are various areas for obtaining the reward such as, ideal stars, ideal supervisors, songs, visual effects and so on. After sending, the Oscar board has actually chosen couple of amongst them then the competition is begun to discover the ideal movie in various groups. In listed below pointed out website you will certainly figure out exceptionally great oscar movie winners having actually attained the honor. There is additionally a short summary on together with the movie where you could see the information of the movie additionally, such as the launch day, name of the supervisor, the tale and so on.
If you're finding for highly unique best picture academy awards, you have actually stay on the best blog post.
Source: buzzfeed Recommenced Article:best
Image credit: Columbia Pictures
Image credit: United Artists
Image credit: MGM
Image credit: Moviestore Collection / Rex / REX USA
Image credit: Fox Searchlight Pictures
Image credit: Columbia Pictures
Image credit: Columbia Pictures
Image credit: Columbia TriStar
Image credit: Orion Pictures
Image credit: Paramount Pictures


text: Sorting type: Most visited Most visited Alphabetical | The Category of the people who are leaders. Pages in category "Leaders" Lady Shiva Anarky Ra's al Ghul Professor Pyg Tobias Whale Killer Croc Mr. Toad Silver Monkey Phosphorus Rex Retrieved from "http://beware-thebatman.wikia.com/wiki/Category:Leaders?oldid=11966" Ad blocker interference detected! Wikia is a free-to-use site that makes money from advertising. We have a modified experience for viewers using ad blockers Wikia is not accessible if you've made further modifications. Remove the custom ad blocker rule(s) and the page will load as expected. Categories: Add category Cancel Save


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Upgrade Kit or PMU?
Discussion in 'Zenmuse H3-2D GoPro Gimbal' started by mcspade, Oct 16, 2013.
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- About her song, "Go (feat. Karen O.)" in which she discusses about the 'New American Dream':
Nowadays, if something isn't accessible, it's boring. We've become a society obsessed with instant gratification, and it's created a warped mentality. The New American Dream is to become rich and famous by happenstance, and to get there with as little work or talent as possible. Everything is about the external – materialism, status, celebrity.
- Her view on the quality of art today and why she thinks it's suffering:
I feel that real art, and people who are trying to do something interesting, original and thoughtful, are not valued as much now as they were in the past. And yeah, the quality of everything is low right now. Some of the lyrics to 'GO' are: 'The quo is so low. Everybody's itching for a thrown to throw. Better sell your status while the quo's so low.' So basically, I'm saying you should get in while you can, while it takes nothing to be considered good.
- And the 'girl power!' comment...her thoughts on women in the 90's vs. women of today:
And the 90s was such a great time for girls! Women are in a weird place right now. I don't get it. Everything you see on TV – Married To The Mob, the fucking Kardashians – is full of girls fighting, like, getting into physical fights. Everybody has a plastic face, full-on make-up. And that's what is considered beauty. [...] Well, in the 90s it wasn't like that. It was grunge and riot grrrl, it was about looking real and messy, and feeling comfortable. Girls looked like they could actually do something, not like they were going to trip on their heels and break their nails. They looked like functioning humans. [...] Everyone is under the pressure. People on the red carpet look crazy. It's a bunch of freeze-faces. But things will come back around.Refreshing to here that.
Well, back to the music, Santigold discussed vaguely about her follow-up album (when the hell is it going to be released??!) and only hints that it's gonna be a good, yet eclectic one. You can take in the rest of the piece here to where she further talks about today's perfectionism culture, about being mean girl while at Quaker school, further thoughts on today's perfectionism culture, and how Eddie Murphy's Coming To America inspires her.
Oh, and for a bonus, here's Santigold at the Austin City Limits music festival last month performing, "Go". Fun stuff.
Camino: Dazed & Confused


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Born June 7, 2008
Weight 3.8 ounces
Length 17 inches
Born June 7, 2008
Weight 3.8 ounces
Length 17 inches
Baby Katia is a sculpt by Anneke Doeven. I loved reborning this little preemie baby. Katia is 17 inches with bent feet and weighs 3.8 oz. She has a cloth body made by Auntie Roseann from "Roseann's Boutique". She has 3/4 limbs. Katia's head has to be supported like a newborn's head.
She is filled with glass pellets and polyfill, so she can travel everywhere in the world without any problems. She has soft and silky curly rooted baby blonde mohair, and rooted eyelashes as well. I get my mohair from "Waterloo Mohair" Katia's head is sealed, so you can wash, comb and set her hair.
She will come to mommy with everything you see in her layette. The red dress and head band, the romper, booties, the adorable preemie outfit was made by Maureen from "The-Eternal-Infant-Nursery" The outfit comes with a bib, bloomers, shirt and hat. She will also bring her non magnetic paci adapted by me and her diaper.
Thank you very much and happy adopting!
God Speed!


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Product Description
H-Priv Mini Kit by SmokLooking for a great-looking mod with versatile performance? You're going to love Smok's H-Priv Mini Kit. Packed with advanced features, this is the latest must-have mod for all types of vapers. Buy the kit and get Smok's Brit Beast tank as well!
The H-Priv features an advanced chipset that can deliver 50 watts of power to the coil in variable power or temperature control mode. It's capable of firing coils down to 0.06Ω and has extensive safety features, including short circuit and overheat protection. Its design genius isn't all hidden away inside, though. The innovative full-height firing grip makes it easy to use however you hold the mod, and the top-mounted screen makes it easy to check and adjust your settings.
Our kit also contains the Brit Beast sub-ohm tank, complete with a conical drip tip mouth piece and capacity to 3.5ml. This is a top-class kit for anyone who wants top performance.
Package Contents
- H-Priv TC Mini Box Mod 50W
- 1x Brit Beast Tank (3.5ml)
- 1 x V8 Baby-Q2 0.6 Ohm Atomizer Coil (Pre-fitted)
- 1 x V8 Baby-Q2 0.6 Ohm Atomizer Coil (Spare)
- 1x Spare glass tank (3.5ml)
- Spare parts
- USB charging / upgrade cable
- User Manual
- Authenticity code
Mod Specification
- Battery Capacity: 1650 mAh
- Variable Wattage power: 1 - 50 watts
- Variable Temp Control power: 200°F - 600°F (100°C - 315 °C)
- Resistance range: 0.06ohm - 2ohm (TC Mode) 0.1ohm - 3ohm (Wattage Mode)
- OLED Screen
- Safety cut out and over discharge/heat protection
- H-Priv Mini Mod - Height: 65 mm Width: 42mm Depth: 24.5mm
- Brit Beast Tank - Height: 43.5 mm Daimeter: 23mm
- 510 Thread Tanks
Customer Reviews (2)
- First classReview by Marsh
So glad i did its bang on easy to use and understand and such a clean vape you don't realise your chugging at 40w and the flavour is amazing!
Spot on vapour uk thanks. (Posted on 14/03/2017)
- Top notchReview by James
All orders placed before 3pm Monday-Friday (excluding Bank holidays) will aim to be dispatched the same day. Any orders placed after 3pm Friday will be dispatched the next working day (Monday).
Please make sure you have inputted the correct address details as amendments cannot be made once the order is being processed or has been dispatched.
All orders require a signature for delivery. If you are not in to sign for your item when delivery is attempted, you will receive a 'sorry you were not in' card and will need to arrange a re-delivery or collect the item from your local collection office.
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We are unable to offer Next Day and 1 hour time slot services to the following postcode areas including Northern Ireland, Channel Islands, Highlands. Please allow for an additional 1-2 working days. Orders to these destinations are sent with Royal Mail Tracked & Signed For: AB30-38, AB44-56, FK17-99, G83, IV1-28, IV30-39, IV52-54, IV63, KW1-14, PA21-33, PA34-40, PH18-26, PH30, PH31-41, PH49-50; HS1-9, IV40-51, IV55-56, KA27-28, KW15-17, PA20, PA41-49, PA60-78, PH42-44, ZE1-3.
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Strawberry Cup Cakes Food
Photographs by: Kyra O'Reilly, Paperchase (background)
January 2011
Pretty cakes that everyone will love! You will need: Equipment
115g/ 4 oz Caster Sugar 115g/ 4oz Butter, soft 175g /5oz Self Raising Flour 150g / 6 oz Icing Sugar 2 Eggs 1 Tablespoon Milk 12 Toppings of your Choice
Photographs by: Kyra O'Reilly, Paperchase (background)
12 Cake Cases Muffin Pan Pink Food Coluring Strawberry Essence Wooden Spoon Mixing Bowl
*This recipe makes 12 cupcakes
Instructions 1. Separate the cake cases into the muffin pan. 2. Put all the caster sugar and the butter into a mixing bowl and cream together until it is pale and fluffy. 3. Gradually beat in the eggs. 4. Stir in the milk, strawberry essence and the food colouring. 5. Fold in the flour. 6. Divide the mixture into the cases and bake for 12 - 15 minutes at 200oC
January 2011
four teacups and saucers from a charity shop for just £4.00. Bargain!
Photographs by: Kyra O'Reilly, Paperchase (background)
To add a bit of old fashioned elegance to your feast, you could place your cupcakes on lace doilies and add matching vintage teapots. Tea, of course, is a an essential. But how about mixing it up with fruit tea or green tea? Better yet, you could make it pink themed event and have Strawberry, Cranberry and Raspberry flavoured treats and fruit tea in the same flavours.
Toppings To make the icing: Sift the icing sugar into a bowl and add warm water a little at a time. Stir the mixture and keep adding watr until all the icing sugar is dissolved and the icing is thick, but able to be spooned out. When the cakes are baked, put a blob of icing in the middle of each of the cakes and add your toppings before it cools and hardens. In the pictures, we used Sugar Roses and Posh Pearls from Asda. But you could also decorate them with sprinkles, PAGE 22
jelly diamonds, hundreds and thousands, and hundreds of other toppings.
How To... Create Your Own Vintage Tea Party Using this recipe, you can make some beautiful cupackes that would look just perfect at a tea party. Simply pop your cupcakes into some fancy looking teacups and arrange however you like. We got this Ming China set of January 2011
Your guests could come in fancy dresses in vintage designs, with pink accessories. Another theme could be roses, with rose petals on the table as decorations and floral print dresses. Or, picking up on the fruity theme, you could have raspberry jelly. All you do is put lots of raspberries in a glass, fill with raspberry jelly (and a little champagne if you're feeling festive) and leave to set. No tea party is complete without tiny sandwiches, but how about dessert sandwiches? Just as cute, but more sweet. Words: Kyra O'Reilly
Published on Feb 8, 2012
A how to article for a niche magazine based on vintage. This tells you how to make 'cup' cakes for a vintage inspired tea party.


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Wine and the Word – March 28th
Save the date! The next Wine and the Word will take place on Monday, March 28th. Gathering at 7:30 p.m. and Scripture reflection at 8:00 p.m. Contact Row for location and details at firstname.lastname@example.com.
All young adults are encouraged to join us…especially to celebrate the Resurrection of our Lord!


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Racing Metro from the Top 14, will be looking to build on their win in the opening Round in Pool 5 of the Champions Cup, when they travel to the Stadio Comunale di Monigo, Treviso on Sunday to take on Benetton Treviso from Italy. The Italians have lost all six matches that they have played in the Guinness PRO12 tournament this season and managed just a single losing bonus point during those fixtures.
Last weekend they began their latest foray into the Champions Cup, with another thumping defeat at the Liberty Stadium in Swansea, where they slumped 7-42, to the PRO12 leaders. Racing Metro meanwhile were embroiled in a titanic battle with the Northampton Saints in Paris, where ill-discipline might easily have cost the hosts dear. They managed to ride out two yellow cards, and despite a late Northampton try that reduced the deficit to 11-13, Racing scored a last minute converted try, to deny their visitors a losing bonus point.
Neither side has covered themselves in glory over the years in the Champions Cup, with Treviso winning just 18 times, with one draw, from the 97 fixtures they have played. While Racing's record isn't much better, with 8 wins and a draw from 25 matches.
Copyright © 2017 www.watchliverugby.tv


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1308 N Main St, Fall River, Massachusetts
$109,9001 Bed1 BathActive
$109,9001 Bed1 BathActive
1308 N Main St, Fall River, Massachusetts 02720 - Why rent when you can own?? Great condo alternative, property has been completely remodeled, modern kitchen and bath, new roof, new plumbing, new electrical, recessed lighting, ample storage space in basement. Not a drive by. A Must See!
Listing Courtesy of Silva Realty Group, Inc.
"Debra was great through the entire sale process. She's extremely professional, responsive, practical and a real pleasure to work with. Highly recommend her whether you're selling, buying or both!"


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Now, I also noticed that the icon had changed, and instead of being Daemon Tools Lite icon, it was another icon, akin to the windows "I can't find your icon" icon. Why don't my users have separate desktops in Windows 10? Ask a question usually answered in minutes! epicandamazin 35,500 views 11:07 How to Open the Command Line in Windows 7 - Duration: 2:57. his comment is here
It wont let me open my torrent I downloaded. Skip navigation UploadSign inSearch Loading... Loading... This Daemon Tools Bin Error In Command Line error code has a numeric error number and a technical description.
thenewboston 68,048 views 7:31 Accelerated Learning: How To Get Good at Anything in 20 Hours - Duration: 23:28. Note: This article was updated on 2016-11-13 and previously published under WIKI_Q210794 Contents 1.What is Daemon Tools Bin Error In Command Line error? 2.What causes Daemon Tools Bin Error In Command Category Science & Technology License Standard YouTube License Show more Show less Loading... Sign in Statistics 9,725 views 59 Like this video?
under the Start menu, hit browse, go to My Computer from the browsing menu, open the virtual drive you created, then select AutoRun or Setup and open it. Program Info Programs that may interest you WinMerge open source visual text file ... You can use following commands and parameters to operate DAEMON Tools Lite from command line ... Daemon Tools Lite Download What do I do?
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SUSCRIBETEツ 218,776 views 6:31 Error in Command Line - Daemon Tools Lite - Duration: 1:04. Daemon Tools Free Download FREE KKZ 281,539 views 4:10 solucion errores de Daemon tools Pro - Duration: 7:48. The Daemon Tools Bin Error In Command Line error may be caused by windows system files damage. Please only answers if you know how the game works.?
What can I do to prevent this in the future? http://www.techyv.com/questions/daemon-tools-lite-error-command-line Powered by vBulletin Version 4.1.12Copyright ©2000 - 2016, Jelsoft Enterprises Ltd. Daemon Tools Lite Error In Command Line Windows 7 Autocad 2010 "L" command error? Daemon Tools Lite Error In Command Line Windows 8 Until today all was OK.Now ,many of the icons disapeared and appeared the Deamon icon all over.
Where are jeeps on sale? this content Please try again later. burlingamepj 61,995 views 2:57 Command Prompt Tutorial for Beginners - Tips & Tricks - Duration: 9:29. About Press Copyright Creators Advertise Developers +YouTube Terms Privacy Policy & Safety Send feedback Try something new! Daemon Tools Doesn't Work On This Version Of Windows
Paisa4life102 99,286 views 8:18 How to fix Daemon Tools error - "Unable to mount image.File not accessible" (Read description) - Duration: 4:07. Answer Questions Xbox, PlayStation, or PC? Sign in 10 Loading... weblink DAEMON Tools Lite Daemon Tools Lite is a virtual disc emulator for your personal computer.
Close Yeah, keep it Undo Close This video is unavailable. Use "ro" if an image you want to mount should be mounted as read-only. betox matesta 22,444 views 1:20 Loading more suggestions...
Then hit OK. In DOS, OS/2, and Microsoft Windows, a batch file is a text file containing a series of commands intended to be executed by the command interpreter. You can only upload videos smaller than 600MB. About Press Copyright Creators Advertise Developers +YouTube Terms Privacy Policy & Safety Send feedback Try something new!
Syntax: -unmount letter , where letter is a letter of the virtual device you want to eject. path is a path to the needed image. One more step Please complete the security check to access www.techyv.com Why do I have to complete a CAPTCHA? check over here An incomplete installation, an incomplete uninstall, improper deletion of applications or hardware.
Published on Jan 19, 2014In This video I will be showing you how to fix Error in Command line bug. No dice. If you are on a personal connection, like at home, you can run an anti-virus scan on your device to make sure it is not infected with malware. Reply With Quote 04.09.2009,19:37 #10 Blazkowicz GERMAN TRANSLATOR Join Date 09.11.2005 Posts 6,401 Starting DAEMON Tools.
DAEMON Tools Pro and the command line error doesn't suppose to happen. What is the better console for games and the overall communities? Also, I have tried reinstalling Daemon Tools windows-7 file-association share|improve this question asked Jun 20 '13 at 2:02 Gareth Jones 2472513 Have you tried simply (uninstalling and) reinstalling Daemon Loading...
Click on the DT tray icon, then right-click menu -> Options -> Shell Integration.