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Thorndale Acres (GNIS FID: 1595521) is a populated place located in Natrona County at latitude 42.82 and longitude -106.313.
The elevation of Thorndale Acres is 5,318 feet. Thorndale Acres appears on the Casper U.S. Geological Survey Map. Natrona County is in the Mountain Time Zone (UTC -7 hours).
Natrona County: Cities & Towns | ZIP Codes | Features (airports, churches, hospitals, etc.)
BIG Map |
Driving Directions |
Data Source - USGS GNIS FID: 1595521
BOUNDARY MAPS: Casper Division | Natrona County
Mills, WY
(3.1 miles WNW)
Casper, WY (3.4 miles N)
Evansville, WY (3.6 miles NE)
Mountain View, WY (4.5 miles WNW)
Brookhurst, WY (4.7 miles NE)
Hartrandt, WY
(4.9 miles NNW)
Casper Mountain, WY (6 miles S)
Red Butte, WY (6.3 miles W)
Bar Nunn, WY (6.7 miles NNW)
Vista West, WY (7 miles WNW)
Allendale, WY
(< 0.1 mile)
Midwest Heights, WY (3.4 miles NW)
Strouds, WY (4.3 miles NE)
Paradise Valley, WY (4.3 miles W)
Richardson Acres, WY (5.6 miles NNW)
Red Buttes Village, WY
(5.6 miles W)
Crimson Dawn, WY (6.3 miles SSE)
Air Base Acres, WY (7.9 miles WNW)
Goose Egg, WY (9.7 miles WSW)
Cow Hollow, WY (10.7 miles ENE)


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Carmike to buy three Birmingham Rave cinemas
Carmike Cinemas Inc. will purchase 16 movie theaters currently operated by Rave Cinemas LLC, including Rave's three theaters in Birmingham.
The purchase, expected to close in the fourth quarter, will transfer ownership of Rave's local theaters, Lee Branch 15, Patton Creek 15 and Vestavia Hills 10, to Carmike. Those theaters were operating under the Rave Motion Pictures brand.
Additionally, Carmike (Nasdaq: CKEC) will acquire Jubilee Square 12 in Daphne, Valley Bend 18 in Huntsville and Wharf 15 in Orange Beach. Other Rave theaters in the deal are in Florida, Indiana, Illinois, Pennsylvania, Tennessee and Texas.
According to a Carmike press release, the purchase price includes $19 million in cash and $100.4 million of assumed lease obligations.
Carmike CEO David Passman called the purchase an "opportunistic development," noting Carmike's plan to expand its footprint to 300 theaters with 3,000 screens through acquisitions.
Rave Cinemas is a portfolio company of BV Investment Partners.

subset: commoncrawl


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Derek Bonikowski
4523 Avenue C Austin, TX 78751 firstname.lastname@example.com HOME 512-419-9504 CELL 512-779-4963 Profile Experienced, results-oriented, School of the Art Institute of Chicago, Animation Program 1994-1996 Skills Extensive knowledge of animation in Maya.
Gils Resume UT
Austin, Tx 78745 (512) 423-7005 firstname.lastname@example.com www.gilsfilms.com I also assist the school with A/V and Mac computer needs. While here I Volunteer DJ for KNTU student radio while a student at The University of North Texas
Austin Wedding DJ Gig Log, Event, Up Lighting, San Marcos …
4:23 Event Log – School Prom Lighting, Uplighter, Fairy Lights (Gig log) by BDJCEvents 367 views 3:27 DJ AzTeX 512-779-5219 Event Center Austin, TX July 3, 2010 by Cesar Valiente 924 views 7:58 Wedding DJs San Antonio by Alfredo n Janine Perez 161 views
2012 Texas PPA
April 29 – May 4, 2012 Texas School 2012 Addison, TX June 24 – 27, 2012 TPPA Summer Roundup Austin (visitor's guide) and his work is sold in galleries including the Texas State Capital and the Texas State History Museum. He won first
DJ Doc Coutee, JJ's Bar & Lounge, 9503 Hwy 1, 9pm-1am. 318/352-8757. Jan 2,6,13,16,20,27 Woden High School Gym, Call Lisa Littleton at 936/558-3637 for more information. Jan 16 . Stephen F. Austin Planetarium "Marsquest," SFASU Planetarium, SFA Campus,
I. Hires To Full-time Positions – Univision.com – Últimas …
One University Station A0901 Austin TX 78712-0110 (512) 471-9421 staying in school and drug free! DJ Hamm and Biggie Paul attended Dilly Elementary Career Day on 5/25/04 spoke to Mary Harper Middle School students in Dilly, TX about their radio
Harlem Shake At Spinners Bar & Grill (Austin, TX) Hosted By …
Harlem Shake at Spinners Bar & Grill (Austin, TX) Hosted by DJ 5-Oh Old/New School R&B and Hip-Hop from 10p-Close. Category Entertainment. License. Standard YouTube License Buy "Harlem Shake" on. Google Play eMusic iTunes AmazonMP3;
What Is A DAN! (Defeat Autism Now) Doctor?
Most school districts have pre-k autism programs. Seek that out also and pray for the Lord's healing in your beautiful son. June 19, 2011 at 9:16 pm (6) Jeremy's mom says: Hi Cayden's mom! I just read your post and wondered how your son is doing?
Kashmere Stage Band – Wikipedia, The Free Encyclopedia
Kashmere Stage Band (KSB) was an elite performing unit of the student band at Kashmere High School from the late 1960s until 1978. Contents 1 History 2 Discography 3 References 4 External links History Kashmere High School is located in a predominantly black neighborhood known as Kashmere
WITNESS LIST For
Of School Administrators), Austin, TX Holt, David (Cogdell Memorial Hospital), Snyder, TX Pendleton, DJ (Texas Manufactured Housing Association), Austin, TX On: Kuntz, Jr., William H. (Texas Department of Licensing and Regulation), Austin, TX 5 .
$101 Million In College Financial Aid Awarded To Central …
Graduating High School Seniors Based on Free Application for Federal Student Aid Submissions . April 19, 2013 [AUSTIN, TX] – Central Texas students are headin g to college with were awarded with either a DJ or Photo Booth for Senior Prom through the Austin Chamber. The high schools


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7月 17, 2017 合計視聴数:: 8070 今日は: 2 ★★★★★
Hotel Pulitzer Amsterdam, This 5-star Hotel Pulitzer Amsterdam is located in typical townhouses along the famous Prinsengracht and Keizersgracht canals. It features an on-site gym, courtyard gardens and luxurious rooms. Guests can explore the city in true Amsterdam fashion by using the hotel's private boat service. Famous attractions such as Anne Frank House, Dam Square and the Jordaan neighborhood are within 15 徒歩分. The elegant rooms have typical Dutch decorations and a bathroom with a heated marble floor. They come with an armchair seating corner and flat-screen TVs with pay-per-view movies. Classic fish and meat dishes are served in the canal-view Restaurant Keizersgracht 238. There is also a lounge to relax and a hotel bar. Tram stop Westermarkt is 200 メートル. It provides easy access to the rest of the city and Central Station. (ホテルピューリッツァー Amsterdam hotels 予約).


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For All Of Your Electrical Needs
Are you Looking For an Electrician in British Columbia? We have an Electrical Contractor in your City.
Check out the Cities We Serve Section Below to find an Electrician.
Services We Provide:
Cities We Serve:
Abbotsford, Burnaby, Campbell River, Chilliwack, Colwood, Coquitlam, Courtenay, Cranbrook, Dawson Creek, Delta, Duncan, Fort St. John, Kamloops, Kelowna, Langford, Langley, Maple Ridge, Mission, Nanaimo, Nelson, New Westminster, North Vancouver, Parksville, Penticton, Pitt Meadows, Port Alberni, Port Coquitlam, Port Moody, Powell River, Prince George, Prince Rupert, Quesnel, Richmond, Salmon Arm, Saanich, Squamish, Surrey, Terrace, Vancouver, Vernon, Victoria, Westbank, West Kelowna, White Rock, Williams Lake


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On average, listings lease in the $20's per square foot per year. The Cuyahoga County submarket is seeing a decline in rates. In the last 3 months, the median rate decreased $1 per sqft per year. That's a 2% decrease in rent.
In the last 90 days, 419 listings have been made available, so you'll want to check back regularly for new listings. About 86% of the listings in the Cuyahoga County are subleases, so you might be able to find a shorter term or below market rent. There aren't many listings below 2,000 square feet available, so finding a space for a small business might be tough.
Even though the median size is 3,150 sqft, there are still 0 new availabilities below 2,000 sqft. Most properties in this region are close to 2 stories. Most buildings in this area were built in 1979 and are Class B.
Trends and status of the commercial real estate market in Cuyahoga County.
Market Report
Real time and historical data on commercial real estate listings in Cuyahoga County.


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Guest Post: Best of 2014 | 5 Favourites I Discovered Only RecentlyTuesday, December 23, 2014
Hey everyone! It's Stephanie from theFantasia blogging for Stephanie of Beauty Infinitum! I know, I know, you were probably thinking why I was about to guest blog on my blog!
Today, I am sharing with you the 5 things I discovered recently that has quickly made it to the top of my "Best of 2014" list! Trying to narrow down my favourites to only 5 was a monumental task, but here I am giving it a shot anyhow!
1 // The new LORAC Mega Pro palette set a lot of hearts racin' and broke a few hearts along the way (for those who were unable to get their hands on it). Don't despair though - even though I think it is a fantastic palette for the value, the Lorac Pro 1 and 2 are equally good if you're more into those shades. This palette features more colour variety which I think is fab for the holidays!
2 // The Make Up For Ever HD Primer is a must-have in my travel/everyday makeup bag, especially when I want to have my complexion to look as good in the afternoon as it did in the morning. The to-go version featured here fits easily and perfectly into any tiny purse!
3 // The Stila Collage of Color Lip & Cheek Palette was exclusive to last year's Black Friday sale. I adore this palette so much for anything cheek and lip related - the colours are gorgeous, and you can control the level of pigmentation quite easily. I love how it stains the lips after it wears off!
4 // I received this Giorgio Armani Eccentrico Blush last year, but sadly it broke en route. However, it is a gloriously beautiful pink coral blush. You can control the shade of pink or coral based on how you mix the colours together. The overlay disappeared quite quickly, not that I minded because I didn't like the glitter very much.
5 // If I could have $10 for every person who mentioned why they love the MAC Pro Longwear Concealer so much, I'd be able to have so many backups of this. A fantastic full-coverage concealer that literally works double-duty (as an eyeshadow primer, brightener, etc), I think this is one of the best must-haves from MAC. It is relatively inexpensive at around $22 (last time I bought this anyway), compared to some of the Sephora stuff, and will last you quite some time.
Stila Collage of Color Lip & Cheek Palette // Giorgio Armani Eccentrico Blush
Now it's your turn! Have you tried any of these products before? Which ones are your favourites? As always, I'd love to hear your thoughts! Share with me comment section or through Twitter or Instagram!
Great post, Stephanie! I need to check out some of these products. You can see my guest post on my favourites of 2014 at Trysh's blog, Prairie Beauty. -Stephanie (Beauty Infinitum version!)


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ThemeForest Greek Responsive Magento Theme 10186243
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Language Therapy Reporting »The Ugly Duckling »A Guide To Working With The Deaf Community In The ... »Delayed Access to Visual Language is Neurotoxic »SSE and Franglais »How to Develop Language »A very quick bit on autism and deafness »On opportunities to socialise »On Priority »Deaf voices and speech perception »
Cued speech is no different from shorthand in all respects but modality. Discuss.
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Briess CBW® (Concentrated Brewers Wort) Sparkling Amber is an amber colored, American malt extract. It produces a sweet malty flavor with notes of caramel.
¹ Color figure applies to a mixture of extract with water. Therefore, you may experience a different color, depending on use. ² Specific Gravity applies to a mixture of 1 lb of extract with 1 gal of water. For 'brewer's points', use the final two digits of the figure.
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I read a post where the Autolamps stayed on during the day after someone installed HID headlights.
I know my dash mounted light sensor is working because my dash lights brighten and dim as I go between light and dark ambient light.
The post reminded me that the Autolamps turn on when the wipers are turned on.
What I expect to find on my car is the white wire is pulled to ground even when the wipers are off. I will try looking deeper into this on my car later.
Attached Files
Edited by wrbrower, 12 May 2017 - 07:41 PM.


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Download E-books How to Pass Verbal Reasoning Tests: Tests Involving Missing Words, Word Swaps, Word Link, Hidden Sentences, Sentence Sequences and Verbal Reasoning PDF
By Harry Tolley, Ken Thomas
Verbal reasoning or literacy assessments are common for choice and review reasons in an effort to identify how powerfuble applicants are of their use of English. how one can move Verbal Reasoning checks may also help you organize for such assessments and achieve the boldness to be successful. there's specialist suggestion on bettering talents and try out innovations, in addition to thousands of perform questions that can assist you get used to the kind of questions requested. easy methods to move Verbal Reasoning checks comprises the next sorts of try out: lacking phrases, notice change, notice hyperlink, hidden sentences, sentence sequences and a brand new bankruptcy on verbal logical reasoning. Intermediate in point, it's going to end up worthwhile to college leavers, extra schooling students and people employing for clerical/administrative posts.
Download E-books The Cambridge Companion to Walter Benjamin (Cambridge Companions to Literature) PDF
By David S. Ferris
Providing a entire creation to the idea of Walter Benjamin, the hugely influential twentieth-century critic and theorist, this significant other examines various major facets of Benjamin's paintings. subject matters of contributions contain Benjamin's dating to the avant-garde hobbies of his time; his theories on language, mimesis and modernity; and his relevance to trendy cultural reviews. extra fabric contains autobiographical writings, a advisor to additional studying and a chronology.
Download E-books Bilingualism: A Social Approach (Palgrave Advances) PDF
By Monica Heller
The individuals to this quantity supply a serious exam of the suggestion of bilingualism because it has constructed in linguistics and of its use in discourses of social law in country and civil society within the 20th and twenty-first centuries. They try to circulate the sector clear of a "common sense," yet in truth hugely ideologized, view of bilingualism because the co-existence of 2 linguistic platforms, and to improve a serious standpoint which methods "bilingualism" as a wide selection of units of sociolinguistic practices attached to the development of social distinction and of social inequality lower than particular old conditions.
MONICA HELLER is Professor on the Ontario Institute for reports in schooling, college of Toronto, Canada. Her significant guides within the box of bilingualism comprise Codeswitching: Anthropological and Sociolinguistic views; Linguistic Minorities and Modernity: A Sociolinguistic Ethnography; Voices of Authority: schooling and Linguistic distinction (edited with Marilyn Martin-Jones) and such a lot lately Discours et identitiés. los angeles francité canadienne entre modernité et mondialisation (edited with Normand Labrie).
Download E-books The Force of Language (Language, Discourse, Society) PDF
By Jean-Jacques Lecercle, Denise Riley
This article illustrates how the philosophy of Language, if otherwise conceived, can without delay contain questions of political notion and of emotionality, and provides the sensible case of protective suggestions opposed to abusive speech. This follows a huge attention of the interior voice or internal speech as a attempt case for a brand new method of language, specifically as a fashion of noticeably rethinking the standard distinction among internal and outer via furnishing an account of the way we internalize speech. The book's center deals a considerable critique of orthodox ways to the philosophy of language from Chomsky and others; drawing on ecu political proposal from Marx to Deleuze, it's going to flow past this inheritance to give an explanation for and display its clean notion of language at work.
Download E-books Pensées simples (Pensées simples, Volume 1) PDF
By Gérard Macé
L. a. langue, los angeles littérature, les mythes, los angeles civilisation et los angeles barbarie : telles sont les lignes de strength et les hantises personnelles à partir desquelles se dessine l'unité de ce livre, qui repose aussi sur l'enchaînement des pensées.
La langue : l'auteur se penche non seulement sur le français, mais aussi sur le chinois, le japonais, les hiéroglyphes de l'ancienne Égypte.
Les mythes sont ceux du monde entier.
Quant à los angeles littérature, elle est celle des grands écrivains de l'humanité, notamment les conteurs.
Grand voyageur, l'auteur est particulièrement fasciné par l'Afrique ; d'où des notations inattendues sur ce continent méconnu, automobile le voyage est devenu une expérience personnelle, au même titre que los angeles lecture, le keepsake, los angeles rencontre.
Download E-books Arabic-English Thematic Lexicon PDF
By Daniel L. Newman
The Arabic-English Thematic Lexicon is a useful source for all freshmen of Arabic.
It includes a few 8,000 entries, prepared into issues, together with natural world, food and drinks, the human physique, overall healthiness care, the kin, housing, garments, schooling, IT, activities, politics, economics and trade, the legislations, media, language, geography, commute, faith, arts, technological know-how, and ordinary assets. 3 appendices conceal the names of Arab and chosen non-Arab areas, international locations and capitals, and overseas agencies.
The entries within the Lexicon have been drawn from an intensive corpus of up to date general Arabic vocabulary, in keeping with genuine resources. as well as verbs, nouns and adjectives, the Lexicon contains words and conventional collocations, offering clients with the required vocabulary as a way to speak successfully and hopefully in either written and spoken commonplace Arabic.
The Lexicon presents an quintessential supplement to Arabic grammar guideline and likewise serves as an invaluable reference consultant for all Arabic language users.
Download E-books The Big Red Book of Spanish Grammar w/CD-ROM PDF
By Dora del Carmen Vargas
Sail in the course of the turbulent seas of Spanish grammar and speak with confidence!
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System necessities: computer basically: home windows 2000, XP, Vista
Download E-books Our Magnificent Bastard Tongue: The Untold History of English PDF
By John McWhorter
A survey of the quirks and quandaries of the English language, concentrating on our unusual and beautiful grammar
Why will we say "I am examining a catalog" rather than "I learn a catalog"? Why will we say "do" in any respect? Is the best way we communicate a mirrored image of our cultural values? Delving into those provocative issues and more, Our significant Bastard Language distills 1000's of years of attention-grabbing lore into one vigorous history.
Covering such turning issues because the little-known Celtic and Welsh impacts on English, the influence of the Viking raids and the Norman Conquest, and the Germanic invasions that began all of it in the course of the 5th century advert, John McWhorter narrates this colourful evolution with vigour. Drawing on progressive genetic and linguistic study in addition to a cache of outstanding trivialities concerning the origins of English phrases and syntax patterns, Our wonderful Bastard Tongue ultimately demonstrates the arbitrary, maddening nature of English— and its ironic simplicity because of its function as a streamlined lingua franca in the course of the early formation of england. this can be the ebook that language aficionados all over the world were expecting (and no, it's now not a sin to finish a sentence with a preposition).
Download E-books Verbal Art, Verbal Sign, Verbal Time PDF
By Roman Jakobson
Verbal artwork, Verbal signal, Verbal Time used to be first released in 1985. Minnesota Archive versions makes use of electronic know-how to make long-unavailable books once more available, and are released unaltered from the unique college of Minnesota Press editions.
Roman Jakobson, probably the most vital thinkers of our century, was once wager identified for his function within the upward push and unfold of the structural method of linguistics and literature. His formative structuralism method of linguistics and literature. His early life with the Russian Futurists and next involvement within the Moscow and Prague Linguistic Circles (which he co-founded) ended in a lifelong devotion to basic switch in either literary concept and linguistics. In bringing every one to endure upon the opposite, he enlivened either disciplines; if a literary paintings used to be to a him a linguistic truth, it used to be additionally a semiotic phenomenon - a part of the total universe of symptoms; and notably, for either language and literature, time used to be an indispensable issue, one who produced momentum and alter. Jakobson's books and articles, written in lots of languages and released all over the world, have been accrued in a huge seven-volume paintings, Selected Writings (1962 -1984), which has been on hand in basic terms to a constrained readership. no longer lengthy prior to his dying in 1982, Jakobson introduced jointly this team of 11 essays—Verbal paintings, Verbal signal, Verbal Time — to function an creation to a few of his linguistic theories and particularly, to his paintings in poetics.
Jakobson's introductory article and the editor's preface jointly recommend the diversity of his paintings and supply a context for the essays during this publication, which fall into 3 teams. these within the first part replicate his preoccupation with the dynamic position of time in language and society. Jakobson demanding situations Saussure's inflexible contrast among language as a static (synchronic) procedure and its ancient (diachronic) improvement - a fake competition, in his view, because it ignores the position of time within the current second of language. The essays on time counter the suggestion that structuralism itself, as inheritor to Saussure's paintings, has discarded background; in Jakabson's fingers, we see a fight to combine the 2 modes. In critical workforce essays, on poetic conception, he exhibits how the grammatical different types of daily speech turn into the expressive, hugely charged language of poetry. those essays additionally take care of the similar problems with subliminal and intentional linguistic styles of poetry. those essays additionally take care of the similar problems with subliminal and intentional linguistic styles in poetry—areas which are complex in structural analysis—and offer exemplary readings of Pushkin and Yeats. The final essays, on Mayakovsky and Holderlin, clarify that Jakobson used to be conscious of the fundamental (and in those cases, tragic) bond among a poet's lifestyles and artwork. The ebook closes with essays via Linda Waugh, Krystyna Pomorska, and Igor Melchuk that supply a considerate point of view on Jakobson's paintings as a whole.
Download E-books The Conceptual Mind: New Directions in the Study of Concepts (MIT Press) PDF
The learn of innovations has complex dramatically in recent times, with intriguing new findings and theoretical advancements. middle options were investigated in larger intensity and new traces of inquiry have blossomed, with researchers from an ever broader variety of disciplines making very important contributions. during this quantity, major philosophers and cognitive scientists supply unique essays that current the cutting-edge within the learn of suggestions. those essays, all commissioned for this booklet, don't only current the standard surveys and overviews; really, they give the most recent paintings on suggestions by way of a various team of theorists in addition to discussions of the information that are supposed to consultant study over the subsequent decade. The ebook is an important spouse quantity to the sooner Concepts: middle Readings, the definitive resource for traditional texts at the nature of concepts.
The essays conceal strategies as they relate to animal cognition, the mind, evolution, notion, and language, ideas throughout cultures, notion acquisition and conceptual switch, innovations and normativity, strategies in context, and conceptual individuation. The members comprise such famous students as Susan Carey, Nicola Clayton, Jerry Fodor, Douglas Medin, Joshua Tenenbaum, and Anna Wierzbicka.
ContributorsAurore Avarguès-Weber, Eef Ameel, Megan Bang, H. Clark Barrett, Pascal Boyer, Elisabeth Camp, Susan Carey, Daniel Casasanto, Nicola S. Clayton, Dorothy L. Cheney, Vyvyan Evans, Jerry A. Fodor, Silvia Gennari, Tobias Gerstenberg, Martin Giurfa, Noah D. Goodman, J. Kiley Hamlin, James A. Hampton, Mutsumi Imai, Charles W. Kalish, Frank Keil, Jonathan Kominsky, Stephen Laurence, Gary Lupyan, Edouard Machery, Bradford Z. Mahon, Asifa Majid, Barbara C. Malt, Eric Margolis, Douglas Medin, Nancy J. Nersessian, bethany ojalehto, Anna Papafragou, Joshua M. Plotnik, Noburo Saji, Robert M. Seyfarth, Joshua B. Tenenbaum, Sandra Waxman, Daniel A. Weiskopf, Anna Wierzbicka


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Hash Browns Potato Salad
READY IN: 17mins
Recipe by Alisa Lea
My family would rather have their potato salad made this way than any other and it's so easy I sure don't mind. I can't remember where I learned this but I've been doing it this way for years. No peeling, chopping, boiling, etc. Except for the potatoes I'm just making a guess on the amounts listed. I never measure but I had to put in something to get the recipe posted.
Top Review by Patty N.
really an easier way... holidays will rock!
See Discussion:17 Reviews 1 Tweak
Ingredients Nutrition
- 1 (2 lb) bag frozen hash browns or 1 (2 lb) bag O'Brien potatoes
- 1 cup mayonnaise
- 2 tablespoons mustard
- 1⁄4 cup onion, chopped
- 2 tablespoons pickle relish
- 4 hard-boiled eggs, chopped
Directions See How It's Made
- Poke some holes in the hash brown package with a fork; microwave on High 6 minutes.
- Shake bag to "stir" potatoes; microwave another 6 minutes.
- Open bag and pour into a bowl.
- Season with salt and pepper to taste.
- Add mayonnaise, mustard, chopped onion, pickle relish, chopped boiled eggs. (Use whatever combination your family likes in their potato salad.).
- Refrigerate until ready to serve.


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Bikram yoga and agoura
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Evan Rachel Wood Opens Up About Dating Marilyn Manson at 18
Evan Rachel Wood has been earning acclaim for her film and TV work since she was a child actress in the mid 1990s, but she's recently hit a new level of fame with her lead role on HBO's Westworld as free-thinking robot Dolores. As such, a new Rolling Stone interview with Wood in part reexamines her past life in Hollywood — including her controversial relationship at 18 with Marilyn Manson, who was then 36.
Wood says she first met Marilyn Manson at L.A.'s Chateau Marmont, back when he was still married to burlesque star Dita Von Teese. They began dating and Wood then starred in his video for the song "Heart-Shaped Glasses" (you know, like the ones that belonged to fictional jailbait Lolita's?) in which the couple made out under a shower of blood. To then-teenaged Evan Rachel Wood, this was just romance on top of romance.
"I met somebody that promised freedom and expression and no judgments," Wood says of their relationship's beginnings. "And I was craving danger and excitement. I looked at my mother one day and said, 'Mom, I'm gonna get on this tour bus for eight months and see the world and have a crazy journey and find myself, and if people aren't OK with that, I'm sorry, but I can't live my life for other people.'"
Wood eventually learned that "people" indeed found her union with a makeup-caked rock star twice her age, well, gross.
"Most teenagers are searching for identity, and I was thrown into a situation where I was supposed to have that already figured out," the Thirteen star said. "Then you're demonized for figuring it out and getting messy. People would call me a whore when I walked down the street, and you can't not be hurt by that."
Wood also told Rolling Stone that she was attracted to Manson's androgyny, and came out as bisexual in 2011.
Dita Von Teese blames the demise of her marriage to Marilyn Manson not on Evan Rachel Wood, but on the decision to get married at all.
"I was with him for seven years, we were married for only a year," Von Teese told Khloe Kardashian on the now-canceled show Kocktails With Khloe. "I feel like getting married was sort of like the kiss of death for us because it was sort of like the nail in the coffin. I felt kind of obliged to go through with the ceremony in a way."
Read Evan Rachel Wood's full interview over at Rolling Stone.
Subscribe to WGBF-FM on
Celebrity Breakups, 2016: The Stars Who Split


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155 Tanglewood Place,Marlboro NJ, 07746
Sold Price
2 beds , 2 Full/1 Half baths
Status: Sold
Berkshire Hathaway HomeServices New Jersey Properties
(800) 548-3466
Last Updated: 8/18/2017 9:29 AM
Description for 155 Tanglewood Place Marlboro, NJ 07746
Some words will not translate correctly. By using this feature, you accept this risk and agree to release Berkshire Hathaway HomeServices and its franchisees from any claims or damages resulting from incorrect translation.
Some words will not translate correctly. By using this feature, you accept this risk and agree to release Berkshire Hathaway HomeServices and its franchisees from any claims or damages resulting from incorrect translation.
Listing Information
Gas Water Heater, Public Water Service
Public Sewer
Room Information
Interior Features
Dishwasher, Gas Range/Cooktop, Refrigerator
Carpet Wall to Wall, Vinyl, Ceramic
Central Air
Gas Heat, Forced Air
Woodburning Fireplace
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Assigned Parking Space, Shared Driveway
Vinyl, Brick Trim/Veneer
Pond, Pond Front
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Community Pool, Park Play Area
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Median list price$650,000
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Properties sold95
Median sq ft price$203
Arrows indicate 90 day trend
Listing Price History for 155 Tanglewood Place
Marlboro Real Estate
Marlboro is located in New Jersey. Marlboro, New Jersey 07746 has population of40,671.
The median household income in Marlboro, New Jersey 07746 is $135,929. The median household income for the surrounding county is $85,605 compared to the national median of $53,482. The median age of people living in Marlboro 07746 is 42.4 years.
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text: Utter filth that a troll revolves his gimmick around. Most people hate this kid, except Beliebers. He is also a criminal. Got arrested for DUI, racing, etc. He has wrote several albums, started out as a typical child with a million views on YouTube, he would sing, or play his guitar. He was kinda cool, but that all changed for most people when he started writing albums. His wannabe general, BieberNinja, is one of the many annoying GameFAQs users.


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Classic Henley sweater, worked from the neck down in 42, 46, 50, 54, 58 inches. Read the full description...
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Howdy folks!
Hopefully, this will be a question with an easy answer. When subscribers are imported into the database, do they receive a "Welcome Email"or is that message only sent when users arrive via a web form?
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text:
So me and this guy dated for 7 months and he cheated. Well he wants me back now and apologized for it even texted my mom about it. I asked him why he cheated and he said he was being stupid and that I'm perfect and all this but it still bothers me. I love him to death even wanted to possibly marry him. I let him into my son's life and my baby loved him and called him dad. I want to move forward and create the family picture with him I'm just stuck I guess. I know people can change and people deserve second chances sometimes but I'm not sure what to do to move on from the past if he's serious. Help?
Most Helpful Girl
I think you have to be realistic with yourself, do you think you could trust him again knowing he has done this? Do you think you can forgive him truly, because if you don't this will be hanging over your head, and overtime you will start to feel resentment towards him. You will always second guess his honesty, if you can't forgive him in your heart. With that being said, stay with him only if you believe you can love him even more than you do now, don't stay with him for the picture perfect family you want in your head.00|00|0
It's not about the picture perfect family. It's about trust. Anyway, I'm asking to see if others would give that chance. I have no problem cutting off people who don't want what I have to offer.
I took back a cheater, it was a huge mistake. At the time I thought It was a good choice, but not everyone is the same. I guess it depends on what kind of person he is, and if you think he can be better than he was.


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Alexandra Shulman
Inside Vogue
Who better to tell the inside story of British Vogue in its centenary year than its longest serving editor, Alexandra Shulman? Uniquely placed to give an insight into the fascinating world of fashion and a British institution, Shulman has also given a rich, personal, and sharply observed account of being a businesswoman, entrepreneur, cultural figurehead and mother, in twenty-first century Britain.
Alexandra Shulman has edited British Vogue since 1992. She is a contributor to The Times, Daily Mail, Guardian and Daily Telegraph and lives in London. She is the author of two novels, also published by Fig Tree/Penguin, The Parrots and Can We Still Be Friends.
In conversation with Festival Patron Rowan Pelling, Journalist and Editor, The Amorist


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To quantitate extracellular and intracellular zidovudine (ZDV) and lamivudine (3TC) concentrations in blood and semen of HIV-1–infected men.
Nonblind, single-center, open-label pharmacokinetic (PK) study in 14 subjects receiving ZDV plus 3TC.
Paired blood and semen samples were obtained during 1 intensive visit and 3 single time point visits over 2 weeks. Extracellular ZDV and 3TC concentrations were measured in blood plasma (BP) and seminal plasma (SP), and intracellular ZDV and 3TC triphosphate (TP) concentrations were measured in isolated mononuclear cells using validated methods. HIV-1 RNA was measured in blood and semen. PK parameters were estimated using non-compartmental analysis.
Median (interquartile range [IQR]) SP/BP area under the time-concentration curve over the 12-hour dosing interval (AUC0–12h) ratios for ZDV and 3TC were 2.28 (1.48 to 2.97) and 6.67 (4.10 to 9.14), respectively, whereas individual SP/BP concentration ratios ranged from 1.9 to 91.4. Intracellular median (IQR) SP/BP AUC0–12h ratios for ZDV-TP and 3TC-TP were 0.36 (0.30 to 0.37) and 1.0 (0.62 to 1.30), respectively, whereas individual SP/BP concentration ratios ranged from 0.11 to 2.9. HIV-1 RNA was undetectable in both compartments.
ZDV and 3TC SP exposures are 2- to 6-fold greater than BP exposures. Seminal ZDV-TP exposures are ~40% of those found in peripheral blood mononuclear cells (PBMCs), whereas 3TC-TP exposures are similar to PBMC exposures. PK variability makes individual SP/BP ratios a suboptimal surrogate for genital tract exposure.
Unprotected sexual intercourse is the predominant risk factor for acquiring HIV, with most transmission occur- ring from infected men to male and female partners.1 The efficiency of HIV transmission depends on a variety of factors, including the type of sex act, the viral burden of the infected partner, and the susceptibility of the uninfected partner to HIV infection.2–7 Although behavioral interventions, such as condom use, have been successful in reducing transmission,8–10 approximately 4 million adults and children are infected globally on a yearly basis.1 New and novel prevention methods are urgently needed to slow the spread of the epidemic.
One potential mechanism to slow HIV transmission is the use of antiretroviral drugs (ARVs) to reduce HIV RNA concentrations in infectious secretions. ARV therapy has been shown reliably to decrease HIV RNA concentrations in the genital tract (GT),11–14 and lower semen HIV RNA concentrations are expected to decrease the efficiency of sexual transmission. Chakraborty and colleagues4 predict that a semen HIV RNA concentration of 100,000 copies/mL would result in transmission in 1 per 100 episodes of heterosexual intercourse, whereas a seminal viral load of 1000 copies/mL would decrease the probability of transmission to 3 per 10,000 acts. The relation between HIV RNA concentrations in blood plasma (BP) and semen is imperfect,15–18 and careful examination of viral sequences demonstrates that BP and GT can be viewed as separate viral compartments.19–21 Persistent GT HIV RNA shedding in subjects receiving ARVs has been reported,22 and long-lived resistant variants in the GT represent a particular problem for rebound viremia23 and transmitted resistance.19 It seems likely that poor penetration or altered metabolism of ARVs in the GT contribute to this problem.24
Nucleoside reverse transcriptase inhibitors (NRTIs) such as lamivudine (3TC) and zidovudine (ZDV) form the backbone of a typical ARV regimen, and this combination is currently recommended as an alternative option for initial treatment of HIV infection by the US Department of Health and Human Services.25 Random BP and seminal plasma (SP) concentrations of these drugs have been measured previously,14,26,27 and investigators have noted ZDV and 3TC concentrations to be 2 to 9 times higher in SP than in BP. As with all NRTIs, however, the active moiety is the triphosphate (TP) metabolite formed by intracellular enzymatic processes.28 Higher intracellular 3TC-TP and ZDV-TP concentrations in peripheral blood mononuclear cells (PBMCs) have been correlated with a faster decline in HIV RNA concentrations and an increase in CD4 T-cell counts.29 TP concentrations have not been previously characterized in GT mononuclear cells but are likely critical for NRTI efficacy locally. Here, we report on a comprehensive evaluation of extracellular and intracellular ZDV and 3TC concentrations in the male GT over a 12-hour dosing interval under steady-state conditions.
HIV-infected adult male subjects receiving ZDV/3TC twice daily as part of their ARV regimen were enrolled in a nonblind, open-label, descriptive pharmacokinetic (PK) study to assess the relation between parent drug concentration, intracellular drug metabolite concentrations, and HIV-1 RNA concentrations in BP and SP from May 2000 to June 2003. Subjects were recruited from the Infectious Disease Clinic at the University of North Carolina at Chapel Hill. Exclusion criteria included: age ≤17 years; vasectomy; active bacterial, fungal, or opportunistic GT or systemic infection at the time of enrollment; unwilling or unable to donate semen; abnormal blood chemistries or blood cell counts; or unable to receive ZDV/3TC for any reason. This protocol was approved by the Biomedical Institutional Review Board of the University of North Carolina at Chapel Hill.
In addition to 300 mg of ZDV and 150 mg of 3TC dosed twice daily, subjects could receive protease inhibitors or nonnucleoside reverse transcriptase inhibitors as part of the ARV regimen prescribed by their clinic provider. Subjects received the study regimen for 4 to 48 months before protocol enrollment. Before the PK visit, subjects completed a 7-day dosing card to ensure steady-state conditions; for the visit to continue, subjects must have achieved at least 90% adherence overall and have taken all doses in the preceding 3 days. Subjects were then admitted to the Verne S. Caviness General Clinical Research Center for an overnight stay for intense BP sampling and 2 semen samples. Matching blood and semen samples were also obtained at 3 outpatient visits over 2 weeks to complete the PK sampling from the seminal compartment and to measure HIV-1 RNA response in BP and SP.
At the steady-state PK visit, blood samples were obtained immediately before the next dose (time = 0), and at 0.5, 1, 2, 4, 6, 8, and l2 hours after an observed dose of ZDV/3TC. Semen samples were obtained by masturbation immediately before dosing at time = 0, and again 12 hours after dosing. Paired BP and SP samples were obtained at 3 outpatient visits over 2 weeks at 3, 6, and 9 hours after a dose of ZDV/3TC for extracellular concentrations and intracellular TP concentrations. The time interval between semen collections was designed to avoid potential effects of repeated sampling on drug concentrations in this compartment. Subsequent formal study of the effect of sampling interval of ARV concentrations in semen demonstrates that short sampling intervals have no significant effects on measured concentrations.30
Whole blood was obtained using ethylenediaminetetraacetic acid (EDTA)–containing collection tubes (BD Diagnostics, Franklin Lakes, NJ) and was centrifuged at 1400 g (2800 rpm) for 15 minutes at 4°C. The resultant BP was aliquoted into labeled cryovials and stored at −80°C until analysis of extracellular ZDV/3TC concentrations and HIV-1 RNA concentrations. PBMCs were obtained using 10-mL cell preparation tube (CPT) tubes with sodium citrate (BD Diagnostics) for intracellular ZDV/3TC concentration analyses. After collection and centrifugation at 300 g (1300 rpm) for 30 minutes, the resultant plasma and buffy coat were transferred to a 15-mL Falcon tube and washed with phosphate-buffered saline (PBS). After an additional centrifugation step, the cell pellet was resuspended and viable PBMCs were counted with a hemocytometer using the trypan blue exclusion method. After the cells were repelleted and lysed with methanol, the cellular debris was removed in a final centrifugation step and the methanolic supernatant containing the TP was transferred to a labeled cryovial and stored at −80°C until analyses.
Semen samples were collected into a standard specimen collection cup. After collection, samples were left at room temperature to liquefy for 45 minutes and then centrifuged at 1400 g (2800 rpm) for 15 minutes at room temperature to separate SP from the cellular fraction. SP aliquots were transferred to labeled cryovials and stored at −80°C until analysis of extracellular ZDV/3TC concentrations and HIV-1 RNA concentrations. To isolate seminal mononuclear cells, the cell pellet was resuspended and layered on a Percoll gradient before centrifugation at 1400 g (2800 rpm) for 20 minutes. The cells were removed from the interface, washed with PBS, and resuspended. Cells were then counted and processed for storage using the same method as described previously for PBMCs.
Extracellular and intracellular concentrations in blood and semen were measured using validated and previously published liquid chromatography tandem mass spectrometry (LC/MS/MS) methods.31,32 The dynamic range for extracellular concentrations of ZDV and 3TC was 5 to 5000 ng/mL, with a minimum of 90% accuracy, and interday and intraday variability of 3% to 14% and 1% to 7.6% relative standard deviation (RSD), respectively. The lower limits of quantitation (LLQs) for intracellular ZDV-TP and 3TC-TP were 0.10 and 10.5 pmol, respectively. For concentrations up to 150 pmol, recovery was ≥93%, and the coefficient of variation (CV) for interday variability ranged from 4.5% to 8.4%. The CV for intraday variability ranged from 1% to 8%.
HIV-1 RNA concentrations in BP were determined using the Roche Amplicor Monitor kit (Pleasanton, CA; LLQ = 50 copies/mL) and in SP using the Organon Teknika Nuclisens assay (Durham, NC; LLQ = 400 copies/mL).
PK parameters, including the area under the time-concentration curve over the 12- hour dosing interval (AUC0–12h), were estimated for BP and SP using WinNonlin Professional (Version 4.1; Pharsight, Inc., Mountain View, CA). Half-lives were calculated from λz values obtained from the noncompartmental analysis. For all analyses, concentration measurements lower than the lower limit of detection were imputed as 0 and those lower than the LLQ were imputed as ½ LLQ. Concentration ratios were calculated to describe differences between drug exposure in BP and SP for extracellular ZDV and 3TC and intracellular ZDV-TP and 3TC-TP.
Demographic data for the 14 men enrolled in the study are presented in Table 1. These men ranged in age from 26 to 48 years; 50% were African American and 50% were white. In addition to ZDV/3TC, most (64%) were also receiving a protease inhibitor or a nonnucleoside reverse transcriptase inhibitor. At baseline, the median HIV RNA concentration in BP was 2.6 log10 copies/mL and <400 copies/mL in SP; the median CD4 T-cell count was 512 cells/mm3. Men were followed in this study for 2 to 44 weeks. Over this period, HIV RNA levels declined to undetectable concentrations in blood and semen in all but 1 participant. This subject had been receiving a stable regimen of ZDV/3TC for 3.5 years before enrollment and had undetectable HIV RNA in BP up to 32 weeks after enrollment, with a single detectable HIV RNA measurement of 880 copies/mL at 2 weeks of enrollment.
Table 2 presents median (interquartile range [IQR]) AUC0–12h in SP and BP for ZDV and 3TC and their intracellular TP metabolites. Five of 112 total ZDV BP samples were lower than the LLQ, and imputed values were used for these samples; all other samples were within the quantitation limits for each assay. For ZDV, the AUC0–12h in SP was 3790 (IQR: 2481 to 4783) h·ng/mL, whereas the AUC0–12h in BP was 1479 (IQR: 1175 to 1748) h·ng/mL. By dividing each subject's SP AUC0–12h by their respective BP AUC0–12h, the SP/BP exposure ratio was calculated. Using this AUC ratio approach, rather than using the SP/BP ratios of concentrations obtained at individual time points, provided a robust overall estimate of GT drug penetration. For ZDV, the median (IQR) SP/BP AUC0–12h ratio was 2.28 (1.48 to 2.97), indicating that ZDV exposure in SP was twice that of BP. For 3TC, the median (IQR) SP/BP AUC0–12h was 6.67 (4.10 to 9.14), indicating that 3TC exposure in SP was >6 times that of BP.
In Figure 1A, the median (IQR) time-concentration profile for ZDV depicts higher exposures in SP than in BP over the dosing interval. The maximal concentration (Cmax) observed in each compartment was similar (median SP Cmax = 561 ng/mL, median BP Cmax = 785 ng/mL). Using the available data, the median ZDV half-lives in SP and BP were 6.9 hours and 2.7 hours, respectively.
Figure 1B illustrates 3TC concentrations in SP consistently higher than in BP throughout the dosing interval. Generally, SP concentrations remained constant across the dosing interval. The median 3TC half-lives in SP and BP were calculated to be 7.1 hours and 3.8 hours, respectively.
Figure 2 depicts the median (IQR) TP PK in blood and semen for ZDV-TP (see Fig. 2A) and 3TC-TP (see Fig. 2B). These concentrations were more consistent across the dosing interval than extracellular ZDV and 3TC. For ZDV-TP, the PBMC and seminal mononuclear cell median (IQR) half-lives were 25.0 (5.5 to 28.5) and 14.2 (12.9 to 14.3) hours, respectively. For 3TC-TP, PBMCs and seminal mononuclear cell median (IQR) half-lives were 10.4 (3.3 to 23.1) and 10.2 (1.2 to 22.2) hours, respectively.
For ZDV-TP, the median (IQR) AUC0–12h in SP was 646 (361 to 1029) h·fmol/106 cells, whereas the median (IQR) AUC0–12h in BP was 1460 (1241 to 2172) h·fmol/106 cells. The SP/BP ratio for ZDV-TP was 0.36 (IQR: 0.30 to 0.37). For 3TC-TP, the median (IQR) AUC0–12h in SP was 82,068 (64,342 to 139,404) h·fmol/106 cells, whereas the AUC0–12h in BP was 108,600 (IQR: 78,687 to 164,984) h·fmol/106 cells, yielding an SP/BP ratio of 1.0 (IQR: 0.62 to 1.30). Although extracellular GT concentrations were higher than BP, the intracellular TP concentrations in seminal mononuclear cells were similar to, or lower than, PBMC concentrations. For ZDV-TP, the SP/BP AUC0–12h of 0.36 indicates that the seminal cell exposure was approximately 40% that of PBMCs. The SP/BP AUC0–12h ratio of 1.0 for 3TC-TP indicates equivalent exposure, however.
Figure 3 compares SP/BP concentration ratios at each collection point for the 4 analytes. The concentration ratios for ZDV-TP and 3TC-TP did not differ appreciably over time, whereas they were highly dependent on the time of sampling for parent ZDV and 3TC. For ZDV and 3TC, individual SP/BP concentration ratios ranged from 1.9 to 91.4 and from 1.9 to 30.5, respectively, with CVs ranging from 60% to 285%. In comparison, parent drug AUC0–12h ratio CVs ranged from 48% to 87%. Samples obtained early in the dosing interval gave lower SP/BP ratios, whereas those obtained later in the dosing interval gave higher ratios. This is particularly evident for ZDV, which maintains high concentrations in SP over a dosing interval, whereas BP concentrations decline quickly. For ZDV-TP and 3TC-TP, individual SP/BP concentration ratios ranged from 0.11 to 2.9 and from 0.14 to 2.5, respectively.
Correlation analysis to investigate potential relations between extracellular parent drug and the TP metabolite exposures in SP and BP did not provide strong evidence of a direct relation for ZDV or 3TC (r < 0.6, P > 0.07 for all analyses; data not shown).
This is the first study designed to provide full extracellular and intracellular PK profiles in blood and semen for ZDV and 3TC. Using calculated AUCs in this investigation, ZDV SP exposure was approximately 2 times greater than BP exposure, and 3TC SP exposure was approximately 6 times greater than BP exposure. Three previous reports of ZDV and 3TC concentrations in SP using isolated time points reported ZDV and 3TC SP exposures ranging from 2.16- to 9.1-fold greater than BP exposures.14,26,27 By obtaining several timed samples over 2 weeks, this investigation was able to calculate an AUC0–12h in SP, which, when compared with the AUC0–12h in BP, provides a more accurate estimate of drug penetration over a dosing interval.
Different ARV exposures in the GT relative to BP have been reported for men and women,14,24,33–40 and the exact physiochemical properties that govern drug passage into GT secretions are currently unknown. Differences exist between classes of agents and between specific agents within each class. This behavior in the male GT is consistent with steady-state GT behavior in women (3TC 4-fold higher in GT, ZDV 2-fold higher in GT).24
Similar to our previous report for the nonnucleoside agent efavirenz,33 extracellular ZDV and 3TC individual SP/BP concentration ratios change considerably in a single subject over the dosing interval because of different rates of drug penetration into the GT. Therefore, the use of AUC0–12h ratios provided a more robust measure of overall drug exposure in SP relative to BP. This can be seen by the lower CVs for AUC0–12h ratios (range: 48% to 87%) compared with individual concentration ratios (range: 60% to 285%). Given the logistics of seminal sample collection for constructing an AUC0–12h, however, there is some increased variability around the estimates of individual PK parameters (particularly Cmax).
Unexpectedly, this investigation found that elevated extracellular ZDV and 3TC exposures in semen did not result in elevated intracellular TP exposures. Although 3TC exposure was approximately 6-fold higher in semen than in blood, 3TC-TP exposure in seminal mononuclear cells was similar to that in PBMCs. Despite 2-fold higher ZDVexposure in SP compared with BP, ZDV-TP exposure in seminal mononuclear cells was only approximately 40% of that measured in PBMCs.
Our subjects were patients on therapy for HIV infection, and as such, sampling was limited to within a dosing interval. Although this approach can underestimate half-life, the long intracellular half-life estimates of ZDV-TP and 3TC-TP reported here (median values of 10.2 to 25.0 hours) are similar to those reported elsewhere in PBMCs.32,41,42 The more stable TP concentrations observed over the dosing interval suggest that a single SP/BP concentration ratio may serve as a reasonable proxy for overall intracellular drug exposure in the male GT. Because collection, processing, and analysis of PBMCs and seminal mononuclear cells are complex procedures, using single time points rather than multiple sampling strategies could facilitate research in this area.
The differential TP exposures between PBMCs and seminal mononuclear cells observed here may be attributable to differential cellular activation or different cell populations between the 2 compartments. 3TC (a cytidine analogue) and ZDV (a thymidine analogue) have different intracellular metabolic pathways for activation.28 The enzymes involved in these pathways can be affected by cellular factors, such as growth phase and activity.28 ZDV is preferentially phosphorylated in activated cells,43,44 whereas 3TC is preferentially phosphorylated in quiescent cells.45 These subjects had been on stable therapy for at least 6 months and had been screened for sexually transmitted diseases (STDs) before participating in this study. Therefore, fewer activated mononuclear cells in the male GT could account for the low SP/BP ratio of ZDV-TP. There are currently no data on intracellular drug concentrations in the GT of men with ongoing HIV replication or an active STD, however.
Differential phosphorylation between SP and BP may also be explained by diverse cell populations in the 2 compartments. The distribution of mononuclear cell subsets in semen is unknown. It has recently been observed in PBMCs that different cell types may phosphorylate nucleosides to varying extents, however.46
At the end of the 2-week treatment period, all subjects had undetectable HIV RNA concentrations in BP and all but 1 subject had undetectable HIV RNA in SP. It is notable that this subject had the lowest intracellular seminal exposure for ZDV-TP and 3TC-TP. Unfortunately, viral sequencing could not be performed on his samples.
The small number of men in this cohort precluded meaningful statistical evaluations of drug concentrations with HIV RNA and/or CD4 T-cell response. Other researchers have reported correlations between TP concentrations in PBMCs and drug efficacy,29 with higher TP concentrations leading to faster declines in HIV-1 RNA and quicker improvements in CD4 cell counts. Future PK-pharmacodynamic modeling with these data to explore the highly complex intracellular-extracellular drug concentration relation in BP and SP is planned but is outside the scope of this article.
The GT pharmacology data presented here are important for the health of the HIV-infected individual and to gain insight into the development of drug resistance in the GT. Understanding the pharmacology of nucleoside analogue reverse transcriptase inhibitors, the backbone of ARV therapy, is critical for choosing agents that minimize the development of resistance in the GT. Lower active ZDV concentrations in seminal cells may provide a pharmacologic basis for the male GT as a sanctuary site for HIV replication. Sexual transmission of resistant HIV is becoming increasingly common as ARV treatment becomes more widely available,19,47–53 and the choice of drug regimen clearly drives HIV resistance patterns in the male and female GT compartments.54–56 In addition to these seminal TP data for 3TC and ZDV, tenofovir diphosphate concentrations in seminal mononuclear cells have recently been reported to be 5 times higher than in PBMCs at steady state.34 The ability of tenofovir diphosphate to be equally phosphorylated in activated and quiescent cells may partially explain the high intracellular concentrations,44 although other factors currently under investigation may contribute to these differences.
For prevention of HIV transmission, these data are most critical for elucidating the influence of local drug concentrations on HIV shedding and the development of drug resistance. To assess the ability of drugs to act locally and protect HIV-negative individuals from infection, tissue concentrations of ARVs in the rectum, penile foreskin, and vaginal/cervical mucosa would be the most relevant to evaluate.
HIV is found in all male GT compartments, including organs that contribute to the generation of semen (ie, prostate, seminal vesicles, testicles). Some differences may be observed in the penetration of ARVs into each of these compartments, but they are unlikely to be clinically relevant.57 Recent developments in techniques to measure the fraction of the total drug concentration contributed by seminal vesicle–derived fluid and prostatic fluid should continue to advance the understanding of GT pharmacology and implications for local drug resistance.58
In conclusion, this is the first study to report ZDV, ZDV-TP, 3TC, and 3TC-TP exposures over a dosing interval in SP and seminal mononuclear cells in comparison to BP and PBMCs. These data have implications for development of compartmental resistance and further assist us in understanding ARV activity in the male GT.
Funded by GlaxoSmithKline, the National Institute of Allergy and Infectious Diseases (AI54980; A. D. M. Kashuba), the University of North Carolina (UNC) Center for AIDS Research/National Institute of Allergy and Infectious Diseases (P30 AI50410; A. S. Bridges and S. A. Fiscus), the UNC General Clinical Research Center/National Institutes of Health (RR00046), and University of Puerto Rico Medical Sciences Campus RCMI Programs (1P20RR11126 and G12-RR03051).
The authors thank the study volunteers and the staff of the UNC Infectious Diseases Clinic, the Verne S. Caviness General Clinical Research Center, and the UNC Center for AIDS Research Virology and Clinical Pharmacology and Analytical Chemistry Cores.
Presented in part at the 10th Conference on Retroviruses and Opportunistic Infections, Boston, MA, February 10–14, 2003, and the XIV International World AIDS Conference, Barcelona, Spain, July 7–12, 2002.
G. J. Yuen is an employee of GlaxoSmithKline. As such, he receives a salary and, as part of his compensation package, receives stock, stock options, and other monetary and nonmonetary benefits.
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


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I've never been the one to shy away from mixing prints, colors or textures and this outfit is no exception. There is something about mixing prints in the same family from head to toe because it either turns out like a train wreck or a masterpiece, the thing is you never know before trying. No need to introduce these trousers, I'm pretty sure I've abused them since I got them, but hey if it works right? I think the check prints worked exceptional well together in this look and the cardigan and brown loafers really put the final touch. What is your verdicts?
Talk to you soon
Wearing: Trouser – Zara / Loafers & Cardigan – Asos / Shirt – Kronstadt


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For a wedding photographer visit:Sheri http://lifechangingphotography.com/
Scott Swingle 740-398-9006 email@example.com
Hoffmann Guest House
Gambier House
White Oak Inn
For reception venues contact:
White Oak Inn
Baltimore & Ohio Railroad Depot
Mount Vernon Country Club
Alcove Restaurant
Janet Thompson 330-276-1215 if no answer call
cell phone 614-314-6399. If no answer, email would be better than leaving a message.
email: firstname.lastname@example.com
We do classical, religious, popular, celtic, folk, or a mix (which is the most popular).
Harp : 300.00 includes up to 30 minutes of prelude, processional, recessional, 10 minutes of postlude if needed, and any music during the wedding.
Harp and Violin : 450.00 includes same as above.
Harp and Flute : 450.00 includes same as above.
We don't do rehearsals as we usually don't need to. We practice on our own. We do speak with the officiator before the wedding to get any cues we may need. We show up at least 30 minutes before the prelude begins.
If any other instruments are added, it is 150.00 per instrument. We can add cello, another violin, viola, another flute, or whatever you may want. Just ask.
Do keep in mind the space available.


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- Scott B. Halstead, Nguyen Trong Lan, +7 authors Timothy P. Endy
- Emerging infectious diseases
- 2002
The age distribution of cases of dengue hemorrhagic fever and dengue shock syndrome (DHF/DSS) in infants under the age of 1 year are reported from Bangkok, Thailand, and for the first time for Ho Chi Minh City, Vietnam; Yangon, Myanmar; and Surabaya, Indonesia. The four dengue viruses were isolated from Thai infants, all of whom were having a primary dengue… (More)
Despite a growing body of evidence predominantly, but not exclusively, from Thailand suggesting that the risk of developing dengue shock syndrome (DSS) is greatest following an anamnestic dengue infection, particularly if the most recent infection was with dengue 2 virus, there continues to be debate about the justification for these claims. This report… (More)
A total of 98 patients with dengue shock syndrome admitted into Children's Hospital from February 1973 to February 1974 were randomly selected into 2 groups. A double blind controlled trial of the efficacy of pharmacologic doses of hydrocortisone hemisuccinate was carried out. The 2 groups were confirmed to be completely matched by age, sex and severity of… (More)
Extensive complement activation precedes onset of shock in dengue patients and complement "split products" C3a and C5a could be responsible, directly or indirectly, for the increased vascular permeability and disseminated intravascular coagulation which characterises dengue haemorrhagic fever (DHF) dengue shock syndrome (DSS). As IgG subclasses vary in… (More)
Three studies were carried out to determine the need, acceptability, and efficacy of adding mefloquine to artemisinin derivatives (AD) for the first-line treatment of uncomplicated falciparum malaria. The first was a retrospective study of 255 basic health workers which showed that their recommendation of AD to patients depended on their level of training.… (More)
- Hlaing Myat Thu, Kym Lowry, +6 authors John Aaskov
- Emerging infectious diseases
- 2004
In 2001, Myanmar (Burma) had its largest outbreak of dengue-15,361 reported cases of dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS), including 192 deaths. That year, 95% of dengue viruses isolated from patients were serotype 1 viruses belonging to two lineages that had diverged from an earlier, now extinct, lineage sometime before 1998. The ratio… (More)
- A MacNeil, E Lederman, +11 authors I K Damon
- Zoonoses and public health
- 2010
Orf virus, pseudocowpox virus and bovine papular stomatitis virus, are parapoxviruses, associated with domestic ruminants, which are capable of causing cutaneous infections in humans. Owing to virtually identical appearances in humans, clinical differentiation of these viruses is difficult. We discuss three recent occurrences of parapoxvirus infection,… (More)
The high percentage (20%) of new cases with grade 2 disabilities, and a low treatment regularity of 47% indicated problems in case detection and case holding in Urban Yangon. The fact that Urban Health Centers (UHCs) were not involved in leprosy control programme might have had an adverse influence. To compare the effectiveness of two methods of integration… (More)
A cross sectional study was carried out in a rural area of Myanmar to identify malaria patients' acceptance of artesunate plus mefloquine drug combination and to determine the cost borne by patients. The majority (88.5%) preferred this new regimen rather than the other ones they had used before; conviction of drug efficacy was the reason given for the… (More)


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This is a lovely tune and an amazing performance. It starts with a Scottish (I presume) band with drums and bagpipe and then it's a flute, a bagpipe and a symphony orchestra. Excellent! Video: Andre Rieu and Amazing Grace Watch the video below … [Continue reading]
Limited Edition
I'm not weird. I am limited edition. … [Continue reading]
Big Magic by Elizabeth Gilbert
I just finished Big Magic: Creative Living Beyond Fear by Elizabeth Gilbert and I love it. The book is about creative living, regardless of what you're creating. Whether you're a writer, painter, photographer, do pottery or anything else this book is … [Continue reading]
Rituals and Routines when writing
Over at The Huffington Post is a post about the benefits of routines and rituals in order to get your writing done. Each of us create the rituals that suits us, routines are more generic and worth learning from others. The post list the following … [Continue reading]
Show up, show up
I posted about Bad writing precedes good writing and here's another statement along the same lines. Show up, show up, show up and after a while the muse shows up too. It goes well with Elizabeth Gilbert's A different way to think about creative … [Continue reading]
Bad writing precedes good writing
I posted about That elusive book of mine about a month ago. We have lots of ideas for topics but I haven't done much actual writing. I got stuck with the idea that if I couldn't write well then I shouldn't write at all. Then this quote turned up and … [Continue reading]
Simple questions for writers
Seth Godin has a great post with "simple" questions for writers. The questions are these: What is it for? (What's your intention?) Who are you? (What's your role?) Who is it for? Will it spread? For the full post, go to Simple questions for … [Continue reading]
Sustainable Housing? Try Shipping Containers
I came across an interesting article at Fast Company, So You Want Sustainable Housing? Try Shipping Containers. It's about a Dutch startup converting used shipping containers into off-the-shelf, off-the-grid dwellings. Dutch startup Sustainer Homes … [Continue reading]
Books September 2015
Here's a list of the books I bought in September and the reasons why I bought them. I include book texts to give a hint of what the books are about. Reviews might (or might not) come later. A Well Tempered Heart I bought "A Well Tempered Heart" by … [Continue reading]
Books and reading
I love books, browsing book stores in real life is a pleasure. Despite that I'm not an avid collector with lots of book on shelves. I'm picky which books I buy, it has to click in some way. My favourite online book store is The Book Depository. They … [Continue reading]
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FUEL YOUR SCHOOL Grants Pass Based Colvin Oil Launches 2015 Fuel Your School Program with up to $75,000 Available for Education Projects in Jackson and Josephine Counties Colvin Oil makes it easy to help generate funds for local teachers and students in collaboration with DonorsChoose.org GRANTS PASS, OREGON, Sept. 1, 2015– Colvin Oil and Chevron… Read More.
My Circle K Offers Free Coffee And Fountain Drinks to Keep Black Friday Shoppers Safe
Grants Pass OR – My Circle K, powered by Colvin Oil, is helping fuel all the all-nighters being pulled by the Black Friday Shoppers by offering free coffee and fountain drinks on Black Friday between 12 midnight and 6 am. "We were concerned about individuals who weren't used to being awake during those hours being… Read More.
New Car Wash Opens In Redmond
American Energy/Colvin Oil is proud to announce the opening of their new car wash in Redmond Oregon. Adjacent to the My Circle K and Chevron at 2005 S Hwy 97 in Redmond this new state of the art car wash is now open for operation. This is just another example of allowing the consumer to live full… Read More.


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latetahl Review
Tank top is very good quality, heavy fabric that washed beautifully, no shrinkage. My "security" force looks so official when wearing this shirt.
- How did the image on site compare with the actual product? Very well
- How accurate was the on site description of the product? Accurate
- Please tell us about the quality of the product. High quality
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I might be one of the only people who love moving, but I really do! When I was in college, my roommate and I once moved to the building next door. We didn't even pack, we just put stuff in bins and made a billion trips. We used her office chair to haul the heavy stuff, and we still brag about the fact that we did it in two days. Since then, I have come up with a plan to help me start early and stay organized. I think the trick is to break it up as much as possible. I take the 25 days prior to moving to get a little done each day because moving day is not packing day, especially if you have people helping you move.
Using my Printable Twenty-Five Day Moving Guide can make a move feel much smaller of a task for everyone involved... and it might keep you from using an office chair to carry things! Okay, lets do this!
Day Twenty-Five
Gather Supplies - Most of my moving must haves can all be found in your pantry or at a dollar store, and will keep you from wasting money on moving. My favorite moving supplies are: Drawstring garbage bags, Styrofoam plates, shipping tape, permanent markers, and a pack of labels if you want to get fancy and color code your boxes. If you are at a rental, some spackle for holes and cleaning supplies will also help you get more of your deposit back. Depending on if you are moving locally, or out of town, you may want to pick up a few boxes, but you can often get free ones from stores. I also gather supplies that I already have such as suitcases, baskets, tote bags, and grocery store bags. I will explain the various uses as we count down the moving days.
Also take some time to figure out a labeling system. I could go on and on about labeling boxes. A little bit of attention to detail while packing will make a huge difference when unpacking.
Day Twenty-Four
Create a Storage Space - Figure out a room that you can live without for a month and make some space. I am using my guest bedroom as a "packed boxes room". Also create a corner of the space for items that you want to donate.
Day Twenty-Three
Pack the Books - We want the heaviest boxes on the bottom, so start with books and magazines (yes, I hoard magazines). Use smaller boxes for this so that you can actually move them. Don't forget to clean out as you go, and start adding to the donation pile!
Day Twenty Two
Seasonal Decor - If you don't already have your holiday decor in plastic bins, go ahead and pick up a few so you can consolidate any seasonal decor you have and get those items organized, packed, and labeled. Plastic bins are also really easy to stack so these items can go ahead and go in your space of packed items.
Day Twenty One
Hobby Supplies - Who has time for hobbies when you are moving? I like to paint, sew, etc., so these items will be next. My crafty stuff is in the plastic storage containers with drawers, so this is a great opportunity to get these items organized. I will use plastic wrap around the bins so that the drawers don't come open. Everything else will go in a box.
Day Twenty
Kitchen Phase 1 of 3 - Pack any kitchen items that you use on an occasional basis. Try to get at least half of the kitchen cabinets emptied so you can go ahead and clean the shelves. Use the Styrofoam plates to put between the plates, and grocery bags to wrap fragile items.
Day Nineteen
Assemble a Moving Tool-Kit - I like to have a container of Screw drivers, a hammer, cleaning supplies, etc., ready for when I need them. Once you get packing, you don't want to waste time looking for tools you need to take apart things.
Day Eighteen
Clean out Storage Closets - Donate what you can and pack the rest. Clean the space as needed.
Day Seventeen
Pack Tools that you wont need for the move.
Day Sixteen
Outdoor Items - If possible, move any porch, balcony, deck or patio items to one location. Clean the areas and any furniture that needs it. Clean dirt from pots and throw away any dead plants or items that you don't need.
Day Fifteen
Pack Entertainment Items - Pack games, DVDs, and any entertainment items. Don't forget to clean them out as you go, and maybe you can even make a little extra cash if you trade in your old movies.
Day Fourteen
Two Weeks to Go! Clean any empty rooms and catch up on the plan if needed. Don't get behind, that's how moves become overwhelming. This is also a good time to schedule your utilities, cable, and Internet installation for the new home. Also, don't forget to change your address at the post office and with any magazines or mailers that you get.
Day Thirteen
Pack Office items and organize as you go. Make sure all important documents are in a safe place that you can easily access if needed.
Day Twelve
Pack Dining and Kitchen Decor
Day Eleven
Pack Bedroom and Bathroom Decor
Day Ten
Pack Living Room Decor
Day Nine
Linens - Wash any linens and Towels. If you are using your current curtains in the new home, wash and iron them so they will be ready for the new house. You also want this stuff ready so you can shower and go to bed once you have gotten all the stuff in the new house. Vacuum and clean out your linen closet or wherever your linens were stored.
Day Eight
Decor on Walls - Take down frames, shelves, curtains, or anything that you have drilled in the walls. If any items have specific hardware, put them in a baggie and tape it to the back. Go ahead and dust pictures so they will be ready to hang when you move, and wash and press curtains if you haven't already.
Coordinate the people who will be helping you move, and give them any needed info.
Day Seven
The Kitchen Phase 2 of 3 - Plan out food for the week. Pull aside the items you will need to cook. Have paper products on hand to eat off of, and pack the rest. (Keep an extra box in the kitchen that you can put the rest of the items in on moving day.) At this point the kitchen should be empty except for the food for the upcoming week. Clean the oven, sink, and the inside of cabinets and drawers. If you are renting, pay special attention to cleaning the kitchen because that is what most people loose their deposit over.
Day Six
Toiletries - Put any bathroom toiletries that you use daily in a container, and pack the rest in a plastic bin. Try to set everything upright, but at least its in a plastic bin just in case it leaks. If you you have multiple bathrooms, put all the must haves in one so you can go ahead and clean the others. Wash any rugs or hand towels so they will be clean and ready for the new house. Maybe a note on the door that it has been cleaned might help you avoid redoing any cleaning.
Day Five
Clothes - Plan out any clothes, shoes, or accessories that you will need in the next five days. Go through your clothes and make a donation pile. Today is the day those drawstring garbage bags will come in handy. Leave your clothes hanging and use the garbage bags to tie around the clothes and hangers. You can also use those color labels to color coordinate which clothes belong to which family member. Use your suitcases for shoes, jewelry, and other small accessories.
Day Four
Clean the New House - If you are local, go to the new house and clean that thing! Don't worry too much with floors since you will track through anyway, but focus on the kitchen and bathroom. Put in drawer liners in the kitchen, and any organizing containers. Also take some sticky notes to plan where you want everything to go. This especially makes it easy if you have people helping you move so they can know where to put everything. If you plan on using products with an abrasive smell, it is definitely a good idea to do this a few days in advance so the smell will be aired out. You may also want to go ahead and spray for bugs since the door will be open during moving. A few air fresheners might be nice too. If you are renting, make a list of any issues that you want your landlord to fix or be aware of. This will avoid damages being blamed on you.
If you have people helping you, go ahead and have some bottled water in the fridge and some snacks at the new house. Also take toilet paper and soap for the bathroom.
Day Three
Patch Holes and Clean your current home. If your are renting, this is a must for getting your deposit back.Take unwanted items to a donation drop-off while the spackle dries. Touch up paint where needed.
Day Two
Electronics - Whoever will be setting up the TV and all that good stuff should be the one who packs it. Take pictures of the back of the TV and other electronics so you can remember where everything goes. If you are packing it all in one box.
Kitchen Phase 3 of 3 - Pack any food and kitchen items that you can and have a cooler on hand for packing cold items tomorrow.
Reconfirm the people who will be helping you move. Make it friendly and appreciative, and maybe even tell they you will have some breakfast ready by a certain time. Make sure the air is running at the new home.
Moving Day!
Have some breakfast ready for the people helping you. I recommend the frozen cinnamon rolls that come in the tin container that you bake it in to avoid cleaning. Depending on how long it takes, order some lunch for everyone as well. There are also great crock-pot meals that you can make ahead and have it going in the new house so people can take breaks and eat as needed.
Also, depending on how many people you have helping you move, designate one or two people to be unpacking as people bring in boxes. This is why labeling is such a big deal. It is also why it is so important to label where things will go in the house.
After the Move
If you are renting, go back through and clean everything thoroughly. Schedule the carpet cleaner to come, and enjoy getting your deposit back!
Download 25 Day Moving Countdown


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text: Freelance Cafe West Sundance Institute Panel discussion on the power of docs, Tuesday, Nov 13, 7:30pm, IFC Center, NYC October 29, 2012 MiaLobel Leave a comment Tickets are $16.50. -Mia If you have trouble viewing this email, click here. Sundance Institute Sundance Film Festival Support our Mission Please join Sundance Institute at Doc NYC for a panel discussion on the power of documentary film. Tuesday, November 13, 7:30 p.m. IFC Center, NYC To celebrate the 10th anniversary of Sundance Institute's Documentary Film Program, journalist Glenn Greenwald of The Guardian leads a conversation with Sundance DFP Director Cara Mertes and three prominent DFP supported filmmakers. Each will share a sneak peak of clips from their highly anticipated new films and discuss the power of non-fiction storytelling in the 21st century. Moderator: Glenn Greenwald (The Guardian) Jehane Noujaim (Rafea: Solar Mama) Roger Ross Williams (God Loves Uganda—upcoming documentary) Jeremy Scahill (Dirty Wars—upcoming documentary) Cara Mertes. Director, Sundance Institute Documentary Film Program. SUNDANCE INSTITUTE IS A NONPROFIT ORGANIZATION DEDICATED TO THE DISCOVERY AND DEVELOPMENT OF INDEPENDENT ARTISTS AND AUDIENCES IN FILM AND THEATRE. © 2000-2012 Sundance Institute | All rights reserved Related PostsMedia Ideation Fellowship Applications open TODAYMedia Ideation fellowship deadline Oct 8Media Ideation Fellowship Applications Open September 11KQED Panel Discussion for Filmmakers & Independent ProducersAnnouncing a call for entries for Rough cuts June event, deadline May 14th


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To want to wallow in a bit of self pity tonight? Or am I asking too much?(18 Posts)
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RE: [XP] Quality
Expand Messages
- I know its heresy to say this, but I also use a tool (NOT Rose!) that
reverse engineers the code and produces a UML diagram. I don't do this for
BUFD, just as a way to communicate what we've done. It takes about 5-10
minutes of my day, and provides benefit in two ways: Folks in other parts
of our company who are curious about what kind of crazy design XP results in
can see for themselves, thus reducing their fear of XP, and I have an easy
way to communicate ideas to a larger audience. Even some of our
non-programmers who need to know what's going on can sort of glean what we
are talking about by looking at a nifty class diagram.
Of course that doesn't replace looking at the tests...
Steve Ropa
-----Original Message-----
From: ericheikkila@... [mailto:ericheikkila@...]
Sent: Wednesday, August 01, 2001 6:41 AM
To: firstname.lastname@example.com
Subject: Re: [XP] Quality
Agreed....look at the tests....if they don't exist, write them.
--- In extremeprogramming@y..., Janet Graham <Janet.Graham@n...>
>the team who is inheriting the code should write them, it's the best
> Scott wrote:
> > Unit tests and acceptance tests are the only
> > way this can be
> > done as safely and quickly as possible. Such tests, when
> > kept up to date,
> > are far more valuable to developers than detailed
> > documentation, and they're
> > much more likely to be up to date too.
> Agreed, and if the unit tests and acceptance tests don't exist then
way to get to know the code and fix a few bugs at the same time. "The
code is the documentation" (I stole this).
>tests and acceptance tests to work with? I understand your reluctance
> Paulo, I would start with the test framework, have you got unit
for the team to just jump in and start working with the code but it
really is the best way and when questions arise along the way they
can refer back to the people who wrote the code. Some aspects of XP
are a leap of faith until you have tried them. All I can say is that
I would start with code quality & testing because it's familiar
territory for all programmers whether you do XP or not.
>To Post a message, send it to: extremeprogramming@...
> - Janet
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We are fighting for a clean energy future in Massachusetts at the state and local level.
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Lisa's Summer Node Tour: Building Power with Climate Justice Partnerships
Posted by:
Caitlin Weldon
on Jul 17, 2017
Who is most affected by climate change and why is it important for 350 Mass to build partnerships with "frontline communities?" Lisa Young, our Climate Justice Partnerships Organizer, is visiting every node this summer to facilitate dialogue around this topic and describe 350 Mass' solidarity work and how nodes...
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#PeopleOverPipelines in Otis State Forest
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Caitlin Weldon
on Jun 27, 2017
Last Saturday, climate activists in the Berkshires led by the Sugar Shack Alliance blocked construction of a section of the Connecticut Expansion natural gas pipeline project. Eight people were arrested. Members of the 350 Mass Berkshires node supported the action along with about 80 other pipeline fighters. T...
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Now is the Moment: Get Involved with 350 Mass
Posted by:
Katherine Anderson
on Dec 16, 2016
Since the election, 350 Mass website sign-ups have roughly quadrupled and node meetings have been flooded with new and returning members. Many of us have seen family and friends feeling a newfound urgency to fight for a just and livable world. If you're new to 350 Mass, this is the perfect moment to get involv...
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