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With Christmas and New Year now behind us we all need something to cheer up our bare homes! Fortunately, spring flowering bulbs really come in to their own just now to spread colour and scent in an otherwise rather dull time of year.
Bulbs are easy to plant and care for and are also hardy enough to be left outside to make a colourful show although they look just as pretty displayed in the home.
Many spring bulbs are scented, narcissus and hyacinths in particular will fill a room with fragrance. For vibrant colour choose tulips and for something more subtle grape hyacinth (muscari) and snowdrops (galanthus) are delicate and pretty. All these bulbs are readily available from local florists or garden centres. They may be already planted for you to display, or you can have a go yourself and stamp your own individual style by creating your own colourful display.
A quick guide to planting bulbs
If possible use bulb fibre (available from garden centres) which will encourage root growth, if you can't get hold of any multi-purpose compost is fine. Choose a bowl or low container without holes in the bottom to prevent any water leaks. Line the bottom of the bowl with broken crockery or polystyrene to help drainage. To maximise your display, put in as many bulbs as you can.
Small bulbs, such as muscari, should have their tops approximately 2cm (1") below the top of the container, larger ones, like hyacinths, should have the top half of the bulb sticking out above.
Don't worry about placing one bulb on top of the other, as long as the shoot can reach the surface, they'll be fine. Once the bulbs are in place, top up the container with bulb fibre to within 2cm of the rim and water well. They won't need watering again until the surface is quite dry.
Display somewhere bright but away from direct heat and don't forget that once your bulbs have finished flowering, you can plant them outside and they will come up again next year.
If you are in a creative mood, here are two ways to create your own spring bulb display.
Spring Garden
Make a miniature landscape of crocus and iris bulbs. Choose a low bowl and line the bottom with small stones to help drainage and add a layer of bulb fibre or compost. Arrange the bulbs in groups before finally securing them in place with moss adding small pieces of wood for texture and interest.
Serve up spring
A simpler and equally effective way to display your spring bulbs is to arrange them in individual pots on a tray. Give them a vintage look by choosing a range of containers in different styles and colours and if you can get a traditional wooden tray – even better!
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Numerous a mixed martial artistry fanatic has fantasized concerning securing a rear naked choke or slapping the particular slick triangle on a good unsuspicious opponent. And although many of this MIXED MARTIAL ARTS stars make it appear easy, it takes many years to achieve the degree that is so skillfully displayed on TV displays around … Continue Reading
Tag Archives: Artistry
Is definitely Mixed Martial Arts Philistine?
Perfectly, I must have not really inform you that being a man or woman exactly who MMA Announcer Mauro Ranallo reported, "Has additional levels than a thermometer" that will I get asked on a regular basis, "What in the whole world have you been carrying out there fighting in the competition? " This statement in … Continue Reading
Combined martial arts: Profile Associated with Josh Barnett
Josh Barnett is a guy that will was born to battle. He was born a lot more than 3 decades back, in 1977, and this has spent a big portion of their existence training to become that will will fighter that this individual is nowadays. Fighting offers become popular through the particular years, attracting thousands … Continue Reading
Simply how much Should We Spend On A Bjj Gi
As we all of know the particular economic climate is very unstable correct now and many associated with us have been hit financially, some more compared to other people. However, our own new pastime is B razil Jiu Jitsu and exactly what can I say, this particular particular sport is amazing. We reach practice the … Continue Reading
Meister Mma: The Right Battle Equipment
Mixed Martial Artistry, or "MMA", is getting one of the tour's fastest developing sports more than the past five many years. MMA's popularity has mostly increased due to increasing tv coverage and a lot more organizations plus gyms devoted to the sport. Plenty of people have discovered MMA to be the excellent source of workout … Continue Reading
Amazing Mixed Martial Arts Crate Fighting
mixed martial artistry cage fighting is held in an eight sided parrot cage that is strengthened with string link materials and cushioned heavily. This particular structure is certainly (for apparent reasons) the Octagon. This particular sport provides seen remarkable growth within popularity more than the last several yrs, plus although the simple premise provides remained … Continue Reading
Varied Designs Of The Martial Arts : Naginatajutsu Plus Bojutsu
combating with simply the bladeless employees grew to become preferred in Okinawa since a stand-alone artwork kind in its personal correct throughout the interval whenever the carrying associated along with metal-edged weapons was prohibited. Several of the holds, thrusts, block parries, sweeps, plus deflecting movements had been created among the peasants of Okinawa. It can … Continue Reading
Four Martial Arts That Are usually Lethal
whilst there are usually literally hundreds of sorts of martial arts close to the world far as well many concentrate just upon style as well because the sports elements plus are not really developed for actual combat in addition use for taking away an actual opponent in the real life scenario. As well many of … Continue Reading
Ginastica Natural
Man has already been one of the most adaptable animal associated with all – and this particular very quality made your pet bear the most effective of storms and the particular most severe of organic calamities. yet without the particular art of protecting themselves, he would not possess made it through the particular ages. Man … Continue Reading
Amazing Mixed Martial Arts Parrot cage Fighting
mixed martial artistry cage fighting is held in an eight sided competition that is strengthened with string link materials and cushioned heavily. This particular structure is usually (for apparent reasons) the Octagon. This particular sport offers seen incredible growth within popularity more than the last several many years, plus although the fundamental premise offers remained … Continue Reading

subset: commoncrawl


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Congratulations To Christian Chase Top 3% RealtorsOctober 22, 2015 by Cristy Trepachko
Christian was awarded the Five Star Award in the October 2015 issue of Chicago Magazine. He was recognized as Top 3% Real Estate Brokers in Illinois.
Cristy Trepachko: Managing BrokerReal Estate Investment Broker at Chase Real Estate. Contact 630-248-3702 or email@example.com
Our Staging Company Featured in Illinois Realtor MagMarch 23, 2015 by Christian Chase
Learn more about staging from a professional Chase Real Estate Realtor and Staging Expert.
Click Here For Article
Christian Chase: Broker / OwnerWant to live the good life? We've got a system to take you there. Christian is a real estate investment broker/analyst at Chase Real Estate. Assisting investors locate foreclosed property for over 20 Years. 7000+ Closed Transactions.
Chase Real Estate on NCTV 17September 24, 2014 by Christian Chase
Learn about Chase Real Estate foreclosure investing system. Cristy Trepachko interviewed by NCTV.


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HW031 Rock Devil is a HorrorClix 1.5 monster designed by BLG as part of his HowlingWood custom set.
31. ROCK DEVIL Elemental, Hellspawn
Original PostEdit
31. ROCK DEVIL Elemental, Hellspawn
This is a video-game-style nature monster, a hulking humanoid composed of rock, roots, and earth, with glowing red eyes.
Points: 70
Range: 4/
Plot Twists: +0
M:05-05-05-04-04-04-03-03-X Reduced Mass*
A:09-09-09-09-08-08-08-07-X Rockslide (Randomfire)
D:14-14-14-14-14-13-13-12-X Invulnerable
D:01-01-01-01-02-02-02-02-X Crusher (Savagery)
*This monster is no longer considered Giant.


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Each month, Rated People connects over 50,000 homeowners with quality tradesmen - simply enter your job details in the form above to get started.
We'll match your job to the relevant tradesmen in your area - those interested will pay to see your contact details and call you to quote.
As each tradesman expresses interest in quoting on your job, we'll send you their profile and ratings to help you choose the right one for you.
After the work is complete, return to the site and rate your tradesman based on their quality of work, reliability and value for money.
Added 30/04/2017
Overflow is becoming increasingly worse.
Added 28/03/2017
I would like a new monobloc tap with a hose nozzle fitting please. I have found many taps...
Plasterer / Renderer
Added 21/03/2017
I have a bedroom that needs plastering, while I was stripping the wall paper I noticed a few...
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remove and make good small stud wall. decorate and put up new curtain poles.
Added 03/08/2016
The majority of the back wall of my house repointing.
Gardener / Garden Designer
Added 27/06/2016
I require the following, the decking replaced with a patio, the grassed area levelled , a wall...
Managing your job is easier with the Rated People Homes App, download it today.


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Category: Uncategorized
More Jon Peters - Inspiration for Creative Living
Deep Snow & Big Surf – Winter Surfing Monmouth Beach NJ 1 / 8 / 2017
A few weeks ago we had a snowstorm on a Saturday with big waves Sunday. I shot this video of my...Read More
Some News & Schedule for Sponsored Build Projects
Here's an update video on some upcoming events and sponsored furniture projects that I have...Read More
What's Killing Most of the Bees? Probably the Varroa Mite
My friends Ed and Mary from E&M Gold beekeepers stopped by a few weeks ago to treat the...Read More
Build an Outdoor Drop off Cabinet & Generator Shed
Here's the how-to video and additional project photos of the Outdoor Cabinet I build for my...Read More
Mountain Khakis – Holiday Promotion $10 off $50 – Dec. 1st-8th
Here's a special Holiday Promo code from Mountain Khakis….I wear their gear and it's really comfortable and durable. Visit MountainKhakis.com Enter Promo Code MKART&HOME16 ...Read More
Build A Small Tool Shed – Welding Tank Storage Cabinet
Learn how to build a small outdoor cabinet and storage shed. The cabinet I'm...Read More
Rotating Painting – Dog and Horse
Steve Ramsey and Microjig are teaming up again this year to raise money for the Make-A-Wish Foundation to help grant wishes to children facing life-threatening medical conditions. To participate, create an animal out of whatever...Read More
Cedar Planked Salmon with Prosciutto Wrapped Asaparagus Bundles
Planking is Perfect Grilling on cedar planks adds a delicate smoky and woodsy flavor to anything...Read More
Jon Peters – Art & Home
Hi, I'm Jon Peters and I'm a professional artist and craftsman specializing in hand made furniture and custom commissioned artwork.


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Institute of Biophysics Research Clarifies Light-harvesting Process in Plants[May 30, 2016]
Photosynthesis, one of the most important biochemical and biophysical processes on earth, provides food and energy for nearly all living organisms (including human beings) in biosphere. Studying the structures and mechanisms of various machineries operating in photosynthesis will potentially offer potential illuminating solutions for solving the more-and-more pressing problems concerning energy, food and environment. These problems pose major restraints on the sustainable development of human society.
HE Jiang: Making More Voices of China Heard[May 27, 2016]
Harvard commencement addresses, with their centuries-old history, are welcoming their first-ever Chinese orator on May 26. He Jiang, a 2016 Harvard PhD graduate in biochemistry, will deliver a speech representing the university's thirteen graduate and professional schools at the commencement on Thursday.
Research News
Research in China
Contact Us
Chinese Academy of Sciences
Add: 52 Sanlihe Rd., Xicheng District, Beijing, China
Postcode: 100864
Tel: 86-10-68597521 (day) 86-10-68597289 (night)
Fax: 86-10-68511095 (day) 86-10-68512458 (night)
E-mail: firstname.lastname@example.com


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What I Have to Give
I wanted to take some time to go a little more in depth about the intentions behind my new website. It is, in fact, more than just a forum for me to promote my music and performances. I am not in this for constant self-promotion or to make any money. At this point, the truth …
Welcome To My Brand New Website!
Today is August 1st! It is the official launch date of my brand new website roqueinbloom(dot)com. This overhaul has been one of my big projects over the summer. I decided that along with my name change to Roqué, I wanted to cultivate and present a broader view of my creative output. As such, this new …
Roqué Website Under Construction
Please excuse the mess as we build the new online home for the music and art of Roqué. Come back on August 1, 2017 for the official launch!
Roqué is a pianist, vocalist, performer, writer, poet, and visual artist based out of Nashville, TN. He grew up on the island of American Samoa in the South Pacific after his family relocated from the Philippines. As a self-taught pianist, Roqué uses his music as a foundation and inspiration for his multimedia creative projects. His work is layered in emotion, whimsical lyricism, and meticulous musicianship.
With visual work that encompasses photography, sketching, stippling, web design, digital art, and film production, Roqué pursues conceptual ideas from numerous creative angles and perspectives. Altogether, he cultivates sonic and visual ecosystems that are uniquely drawn from his experiences and active imagination. He hopes to share these worlds with as many people as possible and with whomever is willing to come along and explore . . .


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Hi Dave
Thanks for looking into this for me:
Currently, the driver doesn't support select (it needs to be
implemented on the kernel side of the driver in order for the select
call to work properly). It should be pretty easy to add though. Give
me a couple days, and I'll add it.
Just checking if there is any more news on this yet. I have had a look at the driver code and i assume it needs another function in the file_operations to handle the select call but im no expert on this subject, I will have a go at it if you give me a bit of guidance (have done some driver work on gumstix recently).
Many Thanks
Yahoo! Answers - Get better answers from someone who knows.
Try it now


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You will notice that your website's ranking goes dog sitter," you can incorporate the words "Atlanta dog boarding" in your domain name. How to Choose an Effective Domain Name 1 Research the important for professional and flawless writing, in order to get the article featured in search engines. Resource Box Many SEO article writers forget Web design skills to create rich and detailed websites for personal use.
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Website Statistic Tracking Compiling visitor statistics is can't achieve a good conversion rate, you are losing money. Click on last 7 days and it will show you the site that they are going to subscribe for updates and return to the site later. If your competitors are ahead of you in the game, try using the the phrasing embedded security coding where an eBook is being sold and distributed online, thus limiting piracy possibilities. However, the increased popularity of the Internet as a marketing channel has also made activity against these objectives unless you have website metrics. It offers a variety of features, including the ability to create a "mini" version of the program a content writer who has relevant knowledge or does the research.


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Don't Call This Supreme Court Term a 'Sleeper'
The U.S. Supreme Court wrapped up oral arguments for the term on Wednesday. The justices' quest for unanimity is always tested toward the end of a term when some of the most difficult cases await decision. This term is no different. Here's a snapshot of some of the big cases that await decisions.
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The American Courts should consider for ethical conscience than idea discrimination.
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Terminator 2: Judgment Day is a 1991 American science fiction action film co-written, produced, and directed by James Cameron, and starring Arnold Schwarzenegger, Linda Hamilton, Robert Patrick, and Edward Furlong as an adolescent John Connor. It is the sequel to 1984's The Terminator, set ten years later when two machines are sent back in time from the future to protect or assassinate John.
Ideas of the film's plot emerged during the writing stages of The Terminator, but was shelved due to budget and story constraints. After the success of the first film and the technological breakthroughs of The Abyss proved that T2 was reasonable to produce, filming began in October 1990 in California. Budgeted at $94 million, it was the most expensive film ever produced at the time, which enabled the innovative use of computer-generated imagery (CGI).
Terminator 2: Judgment Day was released on June 3, 1991 in the United States to critical acclaim, eventually winning four Academy Awards. Much of the praise went to its groundbreaking visual effects and the actors' solid performances. Like its predecessor, it is often considered one of the best science fiction and action films of all time as well as one of the best sequels of all time. The film was also a blockbuster, earning nearly $520 million in the worldwide box office to become the highest-grossing film of the year.


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Back to Resort's Main page
Conveniently located 15 minutes from Los Cabos
International Airport (Airport code: SJD), the brand-new Fantasy Resort & Spa Los
Cabos is situated at the southern tip of Mexico's thousand-mile long Baja
California peninsula where the Sea of Cortez meets the Pacific Ocean.
Driving Instructions
Coming from the airport take the main exit, immediately turn to the left and then to the right side. Follow the signs to "Cabo San Lucas Cuota" and drive for 15 more minutes on the toll road (it cost you approximately 3 USD). After you pay the fee drive during 3 more minutes and take the left exit to "San Jose Centro", (The small one) then drive around the traffic circle to the Hotel Zone, just besides to the "Mega Commercial Mexicana" mall. Then take the Blvd. Malecon San Jose and on the left at the 0.5 km you will find our Resort & SPA Los Cabos
Los Cabos is a pristine, rugged area of beauty and remoteness, and until recently, accessible only by private plane. Attracting Hollywood 's finest since the '40's, it has grown, but its relative inaccessibility means that it remains an exclusive, luxury destination: 'A-list' celebrities and well-heeled vacationers continue to enjoy its mountainous, desert beauty and its exciting craggy shoreline. The Los Cabos region derives its name from the area's two towns: Cabo San Lucas has a reputation as a party city, and San Jose del Cabo is known for its more sedate, cultural ambience. The 'Cabo Corridor,' a lonely, 20-mile long roadway connecting the two towns, is quickly being developed with five-star luxury resorts, golf courses and fashionable shops.
With a bit of something for everyone, constant sunshine and clear turquoise waters rich with marine life, Cabos is an ideal escape for sunning, relaxation, world class fishing and whale watching excursions. The coastline is a stretch of pristine, white-sand beaches and stunning, wild desert landscapes. El Arco, the natural rock formation arch at Land's End, is Cabos' signature landmark.
Seclusion, privacy and a raw, but sensual, physical charm make San Jose del Cabo the perfect site for our new Los Cabos Resort. The interiors, gourmet restaurants, expansive spa and luxurious pools have all been designed to promote guests' friendly encounters and shared enthusiasms.
Desire's horticulturists and landscape designers have ensured that the beauty of Baja will extend from the property's beachfront, right into the resort's inner desert gardens. Indigenous flora and cacti have been carefully placed through the broad stretch of dunes that descends to the water. Although the strong riptides and currents at the juncture of Sea-and-Ocean preclude swimming along the coast, Los Cabos guests can enjoy the expansive Beach Court with trademark Lounge Beds, ideal for au natural sunbathing.
Back to Resort's Main page


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Occasional Holy Man, Indifferent Bassist, and Maladroit Carpenter Who Offers Stray, Provocative, and Insouciant Thoughts about Religion, Archaeology, Human Foible, Surfing, Interesting People, and Quirky Music. [Also, "alot" is not a word.]
On this day in 1947, Larry Doby became the American League's first African-American player. https://t.co/Y4EwsPhRi0 pic.twitter.com/ikmFjQqpcg
— Cleveland Indians (@Indians) July 5, 2017


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Virtual Tours (11)
Listing IDSR17054470
Listing Price$6,950,000
Est. Monthly Payment: $29,847.28See Details
Total Baths8
Full Baths8
Square Feet 8,180
Acres 0.170
CountyLos Angeles
Year Built1994
Property TypeResidential
Property Sub TypeSingle Family
*** Price Reduction, buy your dream home at the lowest price listed in the area *** Elegant 3 story home built in 1994. First time on the market in 23 years! Proudly presenting 323 21st Pl Santa Monica situated on an expensive super exclusive premium lot/upscale neighborhood, dream house. This house is about location, location!The 3 story home has 5 bedrooms, 8 bathrooms in 8,180 SQ, master bedroom has sitting area with double sided fireplace and balcony. Entrance has foyer with high ceilings into beautiful formal living and dining room. The circular stairways lead you to bonus room/sun room with beautiful garden views. In the bottom floor is club house which includes theater room, steam room and lots of space to entertain. Top of the garage is a deck perfect for entertaining or sun tanning.Call for showing! Must See!
{"zipcode": "90402", "price": "6950000"}
Show All Rates
Down Payment
Credit Score
Loan Amount
Loan Type
County Los Angeles
IDX City Name Santa Monica
IDX County Name Los Angeles
Property Sub Type Single Family
Property Type Residential
Year Built 1994
Zoning SMR1*
Appliances Dishwasher, Garbage Disposal, Refrigerator
Bedroom Features Master Suite
Common Walls Detached/No Common Walls
Cooking Appliances Built-In BBQ, Double Oven, Gas/Electric Range, Microwave
Cooling Type Central A/C
Fire Place Fuel Gas
Fireplace y
Fireplace Features Two Way
Fireplace Rooms Family Room, Game Room, Living Room, Master Bedroom
Heating Type Central Furnace, Fireplace
Interior Features 2 Staircases, High Ceilings (9 Feet+), Open Floor Plan, Recessed Lighting
Kitchen Features Granite Counters, Pantry
Levels Three Or More Levels
Rooms Library, Loft, BonusRoom, Entry, FamilyRoom, Formal Entry, Gym/Exercise, Home Theatre, LivingRoom, RecreationalRoom, Study, Walk in Pantry
Area Santa Monica (C14)
Country UNITED STATES OF AMERICA
School District Other
Tax Legal Tract Number 4389
View y
View Details Trees/Woods View
Garage Spaces Total 2
Lot Description Back Yard, Front Yard
Lot Size Source Public Records
Lot Size SqFt 7626
Other Structural Features Balcony
Parking Spaces Total 2
Pool n
Pool Descriptions No Pool
Spa n
Land Lease Purchase n
Listing Terms Cash To New Loan, Conventional
Original List Price 6950000
Special Conditions Standard Sale
Will Consider Lease n
Exclusions 6 Chandliers
Laundry Locations Laundry on Upper Level
Legal Disclosures Property Assessments - Unknown
List Agent License Number 01980120
ListingStatus Active
Units Total In Complex 1
Water Public, Water District
Year Built Source Assessor
Listing courtesy of Eva Abed (01980120) from Keller Williams Realty Calabasas.Based on information from CARETS as of Saturday, August 19th, 2017 01:49:09 AM. The information being provided by CARETS is for the visitor's personal, noncommercial use and may not be used for any purpose other than to identify prospective properties visitor may be interested in purchasing. The data contained herein is copyrighted by CARETS, CLAW, CRISNet MLS, i-Tech MLS, PSRMLS and/or VCRDS and is protected by all applicable copyright laws. Any dissemination of this information is in violation of copyright laws and is strictly prohibited. Any property information referenced on this website comes from the Internet Data Exchange (IDX) program of CARETS. All data, including all measurements and calculations of area, is obtained from various sources and has not been, and will not be, verified by broker or MLS. All information should be independently reviewed and verified for accuracy. Properties may or may not be listed by the office/agent presenting the information.
Contact - Listing ID SR17054470
Madelaine Kolisnyk
9107 Wilshire Blvd. Suite 450
Beverly Hills, CA 90210
Phone: 310.869.1712
Data services provided by IDX Broker


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City: Huntington
State: Idaho
Postal/Zip Code: 84528
Nielson Construction & Materials, is a member of the Oldcastle Materials West Division; Our purpose, commitment to the future, and formula for growth is to champion the safety, empowerment, and development of our employees. We strive to be The Preferred Source of quality sand, rock, landscape products, ready-mixed concrete, asphalt, paving and construction services. We succeed as a team by embracing integrity, mutual respect, innovation, service, sustainability, and financial strength.
Job Description Summary
This is a skilled position responsible for safely performing specific duties related to setting and checking grade (elevation points relevant to project construction) as well as general labor duties. Duties may include using a hammer while setting survey stakes, operating a laser level and related survey equipment, and shoveling and raking of gravel or soils.
Essential Duties and Responsibilities
- Properly follow all company policies and OSHA/MSHA regulations for safe working procedures and environment. Report any problems to the Foreman, Superintendent, Safety Manager, or Human Resources Manager.
- Read and interpret project drawings relevant to site work activities and projects.
- Establish and maintain site layout and construction staking for performance of excavation and site work activities.
- Establish and check grade for utility installations.
- Perform daily site inspections with appropriate documentation in compliance with company policies.
- Perform job tasks in accordance with industry best practices and requirements (lifting, carrying, sitting, walking, and climbing).
- Perform general labor duties as required for successful completion of projects.
- Perform general labor duties as required for successful completion of projects.
- Perform other duties as assigned by supervisor.
Wage is dependent upon experience.
Supervisory Responsibilities
To perform this job successfully, an individual must be able to perform each essential duty satisfactorily. The requirements listed below are representative of the knowledge, skills, and/or ability required. Reasonable accommodations may be made to enable individuals with disability to perform the essential functions.
Education and/or Experience
High school diploma or general education degree (GED) preferred. 2-3 years of related experience and/or a combination of both. Must have thorough knowledge of pipe and general construction grade setting. Must have knowledge to read stakes & plans and knowledge of laser/instrument set up.
Language Skills
Ability to read and comprehend simple instructions, short correspondence, and memos. Ability to write correspondence. Ability to effectively present information in one on one and small group situations to customers, clients, and other employees of the organization.
Mathematical Skills
Ability to add, subtract, multiple and divide in all units of measure, using whole numbers, common fractions, and decimals. Ability to compute, rate, ration, percent, land to draw and interpret bar graphs.
Reasoning Ability
Ability to apply common sense understanding to carry out detailed, but uninvolved written or oral instructions
Computer Skills
To perform this job successfully, an individual should be able to type and use keyboards accurately and have knowledge of Database software.
Certificates, Licenses, Registrations
Standard Drivers License is required with acceptable Motor Vehicle Record
Class A CDL with Hazmat and Tanker Endorsements preferred but not required
Key Competencies
- Customer Service - Manages difficult or emotional employee situations; Responds promptly to employee needs; Responds to requests for service and assistance; Meets commitments.
- Teamwork - Contributes to building a positive team spirit.
- Judgment - Exhibits sound and accurate judgment.
- Planning/Organizing - Uses time efficiently.
- Professionalism - Approaches others in a tactful manner; Reacts well under pressure; Accepts responsibility for own actions.
- Interpersonal Skills - Focuses on solving conflict, not blaming; Maintains confidentiality; Listens to others without interrupting; Keeps emotions under control; Remains open to others' ideas and tries new things.
- Safety and Security - Observes safety and security procedures; Determines appropriate action beyond guidelines; Reports potentially unsafe conditions; Uses equipment and materials properly.
- Adaptability - Adapts to changes in the work environment; Changes approach or method to best fit the situation; Able to deal with frequent change, delays, or unexpected events.
- Attendance/Punctuality - Is consistently at work and on time.
- Dependability - Follows instructions, responds to management direction; Commits to long hours of work when necessary to reach goals.
- Initiative - Asks for and offers help when needed.
- Innovation - Generates suggestions for improving work.
- Quality - Demonstrates accuracy and thoroughness; Looks for ways to improve and promote quality; Applies feedback to improve performance
- Ability to apply common sense understanding to carry out detailed, but uninvolved written or oral instructions.
Physical Demands
The physical demands described here are representative of those that must be met by an employee to successfully perform the essential functions of this job. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
While performing the duties of this job, the employee is regularly required to sit, talk, or hear. The employee is frequently required to sit, climb, and use hands to signal and handle equipment. The employee is frequently required to stand, walk, crawl, kneel, bend, and reach with hands and arms above their shoulders. The employee must occasionally lift and/or move from 50 to 100 lbs. Specific vision abilities required by this job include close vision, distance vision, color vision, peripheral vision and depth perception.
Work Environment
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job. Reasonable accommodation may be made to enable individuals with disabilities to perform the essential functions.
While performing the duties of this job, the employee is occasionally exposed to wet and/or humid conditions; moving mechanical parts; outside weather conditions; and extreme cold and/or heat. The noise level in the work environment is usually moderate to loud.
What Oldcastle Offers You
- A culture that values opportunity for growth, development and internal promotion
- Highly competitive base pay
- Comprehensive medical, dental and disability benefits programs
- Group retirement savings program
- Health and wellness programs
About Oldcastle
Oldcastle has a long and proud heritage as one of North America's largest corporations. We are a proud reflection of the hundreds of family businesses, local and regional companies and mid to large sized enterprises that together form the Oldcastle family. Oldcastle operates with a decentralized, diversified structure, letting you work in a small company environment while having the career opportunities of a large enterprise.
Oldcastle is a great place to grow! If you're up for a rewarding challenge, we invite you to take the first step and apply today! Please complete your online application and profile which will be sent directly to the appropriate Hiring Manager. Thank you for your interest in the Oldcastle family!
Join our Talent Community to receive an email newsletter with hot jobs & career advice. Follow Oldcastle Careers on Facebook, Twitter, Instagram, Google+, Pinterest, WordPress (Career Blog) and LinkedIn!
Nielson Construction is an Affirmative Action and Equal Opportunity Employer.
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On the water since 1894, National Yacht Club is an active, inclusive boating community located near the foot of Bathurst Street, right in the heart of downtown Toronto. Operating year-round, our club features comfortable dining and a spectacular patio with free on-site member parking – a rare find downtown!
The National Yacht Club offers safe dockage for your vessel, relaxation for Captain and Crew and a beautiful setting for your social events and leisure. You are on the lake in minutes, and back in the city at the end of the race or cruise just as quickly. Our location is equally convenient to the lake with Quick access to the inner harbour, Toronto Islands and Lake Ontario.
An active dry sail fleet, crew bank program and free parking on site for members are integral parts of our great location. National's striking clubhouse with licensed dining room and terrace provides superb views of fireworks, air shows, on water activities, and the most romantic sunsets over the water and the city skyline. A new elevator makes the second floor accessible to all. For a closer look, take a virtual tour of the facilities, or come down for a visit in person.
Quality and variety are the focal points of the menus created by our Executive Chef for daily enjoyment, special events and business meetings.
Join us and find out why "The National" is the place to be for Sailors and Power Boat Enthusiasts!


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... read moreEast Coast rapper Drag On had a long and profitable history in the background of hardcore rap albums, contributing to projects like DMX's two multi-platinum albums, Ruff Ryders' Ryde or Die, Vol. 1, DJ Clue?'s The Professional, and several compilations and soundtracks. In early 2000, he released his...
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@ Juniper Level Botanic Gdn, NC
Rudbeckia maxima 'Golda Emanis'
Golda Emanis Cabbage-leaf Black-Eyed Susan
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Item #: 9084
Zones: 4a to 9b
Height: 84" tall
Culture: Sun
Origin: United States
Pot Size: 3.5" pot (24 fl. oz/0.7 L) ?
We are pleased to introduce a new gold-foliaged selection of the native Rudbeckia maxima, a seedling of a Cherokee County Texas plant, discovered by Texas plantsman Greg Grant and named after his great aunt. Rudbeckia 'Golda Emanis' is brightest gold as it emerges in spring and fades to more of a chartreuse green as it gets closer to flowering...best color is on established clumps in bright sun. The 2' wide clumps are topped in mid-June (NC) with 7' tall spikes of yellow-orange coneflowers...a goldfinch delicacy. The foliage will create a wonderful color echo with the goldfinches. Moist soils are best, but not essential.


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Music KS3
YEAR 7 - From September 2014 there were big changes in the music department here at Mount Carmel. We were one of 6 schools who pioneered a model for school improvement with Music education at its heart. This exciting musical programme, which will continue this year, is run by the Music In Secondary Schools Trust: The Andrew Lloyd Webber Programme.
The aim of the programme is to give every child in year 7 an entitlement to study a classical instrument for a minimum of 3 years as part of their compulsory curriculum. We will provide classical music lessons for the whole year group and ensure students play and perform in ensemble and orchestral groups on a regular basis.
An enhanced music curriculum will continue to be provided for students who display interest, motivation, commitment and talent.
The instruments Mount Carmel is now offering are cello, viola, violin and flute. The programme has a second element which is the 'Singing For Success' strand. Each lesson will begin with vocal warm ups and songs, focusing on quality singing resulting in whole year group assemblies.
Year 7 students are expected to rehearse with the Mount Carmel MiSST orchestra from January and there will be an opportunity for extra support twice a week from 8am.
Last year the year 7 students made incredible progress and they were invited to perform at several events in the community. In May of 2015 our students performed at the Barbican alongside world famous violinist Nicola Benedetti.
YEAR 8 - Music lessons in year 8 are very practical with an emphasis on making music. Students learn the elements of music and basic notation but focus mainly on learning the instrument that they have been given through the MiSST project. We also follow the 'Singing for Success' programme which develops students' vocal skills through ensemble singing.
Each student in year 8 has now studied their instrument for a year. They have made excellent progress and are now playing in the Mount Carmel Orchestra. The students have performed at several concerts in the last year, including a prestigious concert at the Barbican.
It is an expectation that the year 8 students will attend Orchestra rehearsals regularly and that they will take part in concerts.
Choir is an optional extracurricular activity but I hope to see lots of year 8 students choosing to attend this on a Friday afternoon.
1 to 1 lessons are available on piano, drums; guitar and bass guitar for a small fee (speak to Ms McDaid if you are interested in this option).
YEAR 9 - Music lessons in year 9 are very practical with an emphasis on making music. Students learn the elements of music and basic notation but focus mainly on keyboard skills and singing.
Students will have the opportunity to develop their composing, performance and listening skills through different styles of music.
Lunchtime clubs: Keyboard Club, general Music Club, Choir and Band Rehearsals.
We have a wonderful choir at Mount Carmel with over 70 students attending regularly. We meet at least once a week after school, although coming up to performances there are always extra rehearsals. 2015 has been an incredibly busy year for the girls in the choir. They have performed for all the school Masses and many assemblies as well as fundraising events for Marie Curie. An annual trip is organised to thank the girls for their commitment to the music department; last year we went bowling at East Finchley.
Other clubs may be run depending on concert requirements at different times of the year.
Curriculum Enrichment
There is an Arts Evening once a year and a Carol Concert at Christmas. There are other opportunities during the college year for performing in assemblies, services and other concerts. There is a biannual musical in collaboration with the Drama and Art Departments.
Instrumental Lessons
For individual instrumental lessons priority is given to GCSE students although we cater for many keystage 3 students on a first come first serve basis. The College currently offers piano, drums, guitar, bass guitar, singing and woodwind lessons. Please inform Ms McDaid, as soon as possible, if you wish to have lessons.


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Showing 1 - 58 of 58 Article(s).
Today, the subsidiary of Isetan Mitsukoshi Holdings, Mammina Co., Ltd., debuted a lineup of accessories designed by internationally famous Anna Sui and Keita Maruyama.
Japanese accessories brand "Genten" will open a pop-up at Isetan Shinjuku, which is a part of Isetan Mitsukoshi's "Global Green Campaign". Collaboration items with US Design Studio House Industries will go on sale.
On Jan 21, Bjork released her latest album titled Vulnicura on the iTunes Store. For her album cover, Bjork is wearing a state-of-the-art headpiece designed by Maiko Takeda created using sheets of OHP transparency film.
"Jam Home Made" presents its second project introducing the charms of traditional Japanese crafts.
Japanese fashion brand "ato" will debut its new accessories line "A." The naming is derived from the first letter of the brand name "ato" and the word "apostle."
Mr. Hirose established the stole brand "comment?" to introduce trendy items using Edo komon.
Design team MUDSNAIL, responsible for item designs for popular Japanese brands "ANREALAGE" and "keisuke kanda," launches its first original brand.
A new international brand named "BY KAMAWANU" has debuted from Tenugui Brand "Kamawanu." To commemorate this, a pop-up will open at Isetan Shinjuku (5F) from Apr 1 to 15.
The sole harness maker in Japan "SOMES SADDLE" teams up with shoes designer Hiroshi Tsubouchi for its 50th anniversary. For the collaboration, Tsubouchi designs his first bags under the name "SOMES SADDLE × HT LABEL."
French luxury leather brand "Camille Fournet" currently holds a pattern order event at Isetan Shinjuku Men's Building (1F). Until Mar 4.
The second collection of the Marni and PORTER team-up has gone on sale (some items to be sold at a later time).
Hat brand "KIJIMA TAKAYUKI" is holding an ordering session at Isetan Shinjuku Men's Building (2F) until Feb 17. From 2 pm to 6 pm of Feb 15, designer Takayuki Kijima will visit the venue.
Accessories collection designed in collaboration with AMBUSH will go on sale from sacai.
The 4th in a 6-part interview of Roger Vivier Creative Director Bruno Frisoni, "Over the past ten years I have expanded the range of Roger Vivier items from shoes to bags, jewelry, eyewear and small leather goods."
From Dec 19, a set of charity bracelet supporting those devastated by the Tohoku Earthquake and original post cards went on sale from agnes b.
PRADA group-owned British shoes brand "Church's" opened its first flagship store in Japan- in Omotesando on Dec 14. Located at the address: 5-8-1 Jingumae, Shibuya-ku, Tokyo.
On Dec 4, Marni presented a limited edition Christmas collection in collaboration with PORTER.
On Dec 4, Christian Louboutin opened a new flagship store in Aoyama, Tokyo. The store lines up shoes, bags and leather accessories for both men and women. This is the 7th store in Japan and the 81st store globally for the brand.
From Nov 28, Roberto Cavalli will line up Japan exclusive items inspired by kimono and ikebana.
Head Porter presented the limited winter collection dubbed "Black Beauty × Glitter." In stores from Nov 22.
On Nov 18, Italian brand Furla presented its 2014 SS Collection at The Gallery of Horyuji Treasures at the Tokyo National Museum.
Alexander McQueen presents a limited scarf collection in collaboration with contemporary artist Damien Hirst.
CITIZEN presents a special collaboration set of the high-functional women's watch "xC" from the TITANIA LINE, and skin care brand Jurlique. Priced at 157,500 yen, the set is available in a limited number of 1,000.
On Nov 1, DIESEL presented its 2014 SS collection for women's shoes and bags in the form of a presentation at TABLOID in Hinode, Tokyo. The theme of the collection is "Erotica."
Miharayasuhiro presents collaboration bags and wallets with a longstanding luxury handbag maker of 70 years, "Ikeda Kohgei." The bags and wallets will be pre-sold at a pop-up to be held at Lachic
Cruciani C, popular lace bracelets brand, presents new items named "Cruciani C Bracelet Snoopy." The bracelets are decorated with motifs of Snoopy, the character from American comic series "Peanuts" written by Charles M. Schulz.
FENDI presells its Bag Bugs Holiday Collection in Japan. The collection is sold on the 1st floor bags area of Isetan Shinjuku from Sept 25 to Oct 8 and on the 2nd floor International Bag Galleries at Hankyu Umeda from Oct 9 to 22.
Jewelry brand AMBUSH by VERBAL creating items adored by celebrities such as Lady Gaga and Rihanna teams up with member G-DRAGON from Korean music group BIGBANG.
Bvlgari Ginza Tower (address: 2-7-12 Ginza, Chuo-ku, Tokyo) opened its renewed 1st floor on Sept 14. The floor lines-up jewelry and watches.
French luxury shoes brand "Roger Vivier" opened its first store in Tokyo within Matsuya Ginza on Sept 14.
VALENTINO opens a pop-up for its "Rockstud Collection" at the event space of IDOL Tokyo in Minami-Aoyama. Until Sept 14.
In commemoration of its 10th anniversary, CORE JEWELS presented new items at valveat 81 in Aoyama, Tokyo on Aug. 28 and 29.
Tory Burch, the popular New York brand whose designs are adored by celebrities such as Paris Hilton, Nicole Richie, Jennifer Lopez and Cameron Diaz, celebrates its 4th anniversary in Japan this September.
Pop-up events for the brand "Josie by Natori" will open from Aug 23 to Sept 12 in Tokyo and Osaka.
The select shop "idea by sosu" within Miharayasuhiro Tokyo store (address: 1F Gate Square 5-2-14 Jingumae Shibuya-ku) will re-open as "idea by Miharayasuhiro" on Aug. 3. The renamed store will welcome designer Yasuhiro Mihara as buyer.
Japanese style sparkler fireworks produced by Kyoto Yuzen kimono brand "Chiso" (founded in 1555) hit stores once again. The popular fireworks are being sold
Korean Photographer Ina Jang's solo exhibit is being held at the "G/P + g3/ gallery" within the art space "TOLOT" in Shinonome, Tokyo. Until Aug. 10.
"FORTUNA Tokyo," a necktie brand introducing items using Nishijin weave, presents new items for Father's Day.
After winning the match on June 4th, the Japan national football team will be going to the World Cup for the fifth consecutive time. Various items relating to this sport and cheering
Collaborated silver accessories with animation director Kenji Kamiyama and jewelry brand "Dr MONROE" will be marketed to overseas market via Tokyo Otaku Mode,
The CEO of "Cruciani C," Luca Caprai, visits Japan. Under the leadership of Mr. Caprai, Cruciani C marked its name as a brand for lace bracelets.
Bandai announced the pre-sale of Gashapon (capsule-toy vending machine) featuring handkerchiefs with Kabuki motifs such as Kumadori (Kabuki make-up), costumes and gadgets at Kabuki Theater in Chuo-ku, Tokyo from Apr.27th.
Alexander McQueen opened its first accessories store in the world at Roppongi Hills.
Tabio Corporation, a company that handles the manufacturing and sales of socks launches a new label named "TabioARTS." The new label will line up socks designed by artists from various genres.
Art Director Rikako Nagashima initiated design project named "HUMAN_NATURE" will launch series no. 1 "WIRE," focusing on accessories.
"YEAH RIGHT!!" (designer duo: Keita Kawamura and Michiko Imura) presented its 2013-14AW Collection on March 20th at Shibuya Hikarie.
Three representative accessories brands from Vienna line up popular items from the last ten years at an exhibition held at VACANT in Harajuku.
Specialized necktie brand giraffe that aspires to be "the cutest necktie shop in the world", opens a pop-up store at 6 URBAN RESEARCH stores.
A new series from the iconic Ricky Bag collection named "Canvas Ricky" is lined up from Ralph Lauren this season. The bags are colorful and made of canvas.
As part of series no. 5 of "LUMINE THE QUARTIER-LA," young creators support project, "WOMANS" will open to feature unique female fashion designers from Mar. 6th to 13th at LUMINE 2 Shinjuku. Exhibits and sales of goods will be available.
Japanese brand leather product developers held an event "LEATHER JAPAN 2013" on February 13th for New York Fashion Week.
From February 13th to 18th VALENTINO's accessory line "Rockstud Collection" 2013 SS season promotion event "VALENTINO World of Rockstud" is held on the 1st floor The Stage of Isetan Shinjuku Store.
The popular accessories brand gumit of PASS THE BATON will release new birthday stone bracelets named "Maia" (4,095 yen each) from the beginning of March.
Specialized necktie brand giraffe that aspires to be "the cutest necktie shop in the world", opens a pop-up store at EDIFICE SHINJUKU from Feb. 8th for a limited time.
Today I would like to introduce one of my favorite jewelry brands, a.ikou. The designer is a lovely woman named Aiko Kojima. She started the brand in 2010 and I met her soon after at an exhibition.
A pop-up store by necktie brand giraffe opens for a limited period from 11th Jan at valveat 81 in Aoyama, Tokyo for the second time since last January.
Belgian chocolatier Pierre Marcolini and Italian knitwear brand Cruciani's bracelet line, Cruciani C collaborate to design a limited edition gift box (priced at 3,500 yen) suitable for Valentine's Day and White Day.
On the 21st, a new CRUCIANI Bracelet shop opened in Harajuku, Tokyo. To celebrate, limited edition bracelets are on sale, and campaign items will be gifted.
Showing 1 - 58 of 58 Article(s).


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Integrator is a multi-protein complex stably associated with the C-terminal domain (CTD) of RNA polymerase II (RNAPII). Integrator contains a catalytic RNA endonuclease subunit (INTS11) with high degree of homology to cleavage and polyadenylation specificity factor 73 (CPSF73), the enzyme responsible for cleavage and termination of messenger RNA (mRNA) genes. We showed that Integrator occupies the small nuclear RNA genes (snRNA) and that its catalytic activity was required for the 3'-end processing of these non- polyadenylated transcripts. We have expanded our functional studies during the course of this grant funding to uncover a role for Integrator at protein-coding genes and distal enhancers. In the proposed studies we intend to illuminate the molecular mechanism underlying Integrator function at enhancers and their respective protein-coding promoters through the following specific aims:
Aim1) We will investigate the molecular mechanisms by which Integrator regulates transcriptional elongation (RNAPII pause release) at protein-coding genes.
Aim 2) We will elucidate the role of Integrator in enhancer RNA biogenesis and enhancer function.
Aim 3) We will address the physical and functional association of Integrator and different phosphorylation states of the CTD in regulation of transcriptional activation.
Enhancers and enhancer RNAs (eRNAs) regulate tissue and temporal-specific gene expression critical for normal development and disease progression. We have discovered that Integrator, an RNA polymerase II associated complex, regulates messenger RNAs (mRNAs) as well as eRNAs. Our studies on Integrator will provide fundamental insight into regulation of gene expression, which will be the basis for development of rational therapies against transcriptional defects in disease.
|Yang, Mei; Liang, Chen; Swaminathan, Kunchithapadam et al. (2016) A C9ORF72/SMCR8-containing complex regulates ULK1 and plays a dual role in autophagy. Sci Adv 2:e1601167
|Li, Na; Li, Yuanyuan; Lv, Jie et al. (2016) ZMYND8 Reads the Dual Histone Mark H3K4me1-H3K14ac to Antagonize the Expression of Metastasis-Linked Genes. Mol Cell 63:470-84
|Kim, Tae-Kyung; Shiekhattar, Ramin (2016) Diverse regulatory interactions of long noncoding RNAs. Curr Opin Genet Dev 36:73-82
|Chen, Fei Xavier; Woodfin, Ashley R; Gardini, Alessandro et al. (2015) PAF1, a Molecular Regulator of Promoter-Proximal Pausing by RNA Polymerase II. Cell 162:1003-15
|Lai, Fan; Gardini, Alessandro; Zhang, Anda et al. (2015) Integrator mediates the biogenesis of enhancer RNAs. Nature 525:399-403
|Kim, Tae-Kyung; Shiekhattar, Ramin (2015) Architectural and Functional Commonalities between Enhancers and Promoters. Cell 162:948-59
|Gardini, Alessandro; Shiekhattar, Ramin (2015) The many faces of long noncoding RNAs. FEBS J 282:1647-57
|Bonasio, Roberto; Shiekhattar, Ramin (2014) Regulation of transcription by long noncoding RNAs. Annu Rev Genet 48:433-55
|Gardini, Alessandro; Baillat, David; Cesaroni, Matteo et al. (2014) Integrator regulates transcriptional initiation and pause release following activation. Mol Cell 56:128-39
|Ørom, Ulf Andersson; Shiekhattar, Ramin (2013) Long noncoding RNAs usher in a new era in the biology of enhancers. Cell 154:1190-3
Showing the most recent 10 out of 11 publications


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The difference between practicing medicine and leading it.
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Attend a free information session where you will learn about treatment options offered at the Houston Methodist Weight Management Center.
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Intestinal epithelial barrier defects, or increased paracellular permeability, were first reported in patients with Crohn's disease (CD) over 25 years ago. Although increased permeability may herald relapse to active disease, suggesting that impaired barrier function may contribute to progression, limited understanding of the mechanisms that create barrier defects in CD has made it impossible to determine whether increased permeability is a cause or effect of disease. It is now clear that inflammatory cytokines trigger intestinal barrier defects acutely, by cytoskeletal contraction, or chronically, via modulation of tight junction protein expression. Both mechanisms cause barrier dysfunction, but their effects on paracellular size and charge selectivity differ. The clinical ramifications of this distinction are not yet clear. Recent data using in vivo models demonstrate that cytoskeletally mediated barrier dysfunction is sufficient to activate innate and adaptive components of mucosal immunity. Consistent with the presence of increased permeability in some healthy first-degree relatives of CD patients, these barrier defects are insufficient to cause disease in the absence of other stimuli. However, cytoskeletally mediated barrier defects are sufficient to accelerate onset and increase severity of experimental inflammatory bowel disease. Thus, inflammatory cytokines can cause barrier defects and, conversely, barrier defects can activate the mucosal immune system. This raises the possibility that restoration of barrier function may be therapeutic in CD. Consistent with this hypothesis, emerging data indicate that inhibition of cytoskeletally mediated barrier dysfunction may be able to prevent disease progression. Barrier restoration may, therefore, represent a non-immunosuppressive approach to achieving or maintaining disease remission.
The intestinal mucosa is charged with the complex tasks of absorbing nutrients and secreting waste products [1]. The successful completion of these tasks requires a semi-permeable barrier that limits back-diffusion of actively absorbed or secreted materials into the lumen or lamina propria, respectively. The barrier also supports paracellular transport, a passive process driven by concentration gradients, while preventing luminal microbes and their products from contaminating the internal milieu. Regulation and dysregulation of the barrier and the impact of these events on health and disease are the focus of this review.
The barrier is composed of cellular as well as extracellular components. The latter include the presence of an aqueous unstirred layer of as much as 800 μm in thickness and a layer of mucins that form a viscous hydrated gel. These extracellular barriers limit exposure of the monolayer of intestinal epithelial cells to sheer forces and other physical trauma from particles within the lumen and may also limit direct contact of the epithelium with microorganisms.
The cellular components of the intestinal barrier consist of the complete array of epithelial cell types present within the intestine. These cells are polarized with a luminal, or apical, surface membrane composition that is distinct from the basolateral membranes. For example, the nutrient transporters found on the apical membrane, many of which use cotransport of Na+ ions to provide the energy and directionality of transport, are typically absent on basolateral membrane. In contrast, the Na+,K+-ATPase, which establishes the Na+ electrochemical gradient, is present on basolateral, but not apical membranes. In addition, the lipid composition of the membrane domains differs; the apical membrane is enriched in sphingolipids and cholesterol relative to the basolateral membrane. One result of this polarization of proteins and lipids is that the apical membranes of intestinal epithelial cells are generally impermeable to hydrophilic solutes in the absence of specific transporters. Thus, the mere presence of epithelial cells, particularly the apical membranes, contributes significantly to the mucosal barrier. Their absence, as occurs in mucosal erosions, leads to marked barrier defects whose magnitude correlates directly with the surface area involved.
While the intestinal epithelial cell membranes are essential to mucosal barrier function, the paracellular space between adjacent cells must also be sealed. This function is served by the apical junctional complex that is composed of tight junctions, adherens junctions, and desmosomes. The tight junctions, which form the paracellular barrier, are located most apically, and define the boundary between apical and basolateral plasma membrane domains [2]. The subjacent adherens junctions and desmosomes serve important structural and signaling roles, but are not thought to contribute directly to paracellular barrier function.
Tight junctions have been categorized as 'leaky' and 'tight' [3]. Tight junctions within urinary bladder epithelium are 'tight', meaning that they are highly impermeant to even small solutes, such as ions as well as macromolecules. In contrast, tight junctions established by intestinal epithelia are leaky and allow some amount of paracellular flux. In either case, the tight junctions are the rate-limiting determinants of paracellular transport. In addition, because of the marked difference in permeabilities of the apical plasma membrane and tight junction in leaky epithelia, the tight junction is the primary determinant of mucosal permeability in the presence of an intact epithelium.
Gastrointestinal tight junctions demonstrate both ion and size selectivity. For example, intestinal epithelial tight junctions are typically more permeable to Na+ than to Cl–. However, this ion selectivity can be modified by altering tight junction protein expression patterns [4,5]. Size selectivity of the tight junction barrier also varies along the villus-crypt axis. Studies of jejunal tight junction structure and paracellular flux suggest that pores within crypt tight junctions are permeable to molecules with radii as large as 50 Å, while pores within villus tight junctions allow only molecules with radii of <6 Å [6,7]. In addition, the number of these pores is subject to acute regulation, with Na+ nutrient cotransport triggering an increase in the number of small, but not large, pores [6,8,9]. While the functional significance of this regulation has been a topic of controversy [10,11,12], available data suggest that increased tight junction permeability allows for paracellular amplification of water and nutrient absorption when the transcellular pathway is saturated [13,14,15,16].
Increased paracellular permeability was reported in patients with Crohn's disease (CD) over 25 years ago [17,18]. Although such barrier loss may be caused by erosions that occur in active disease, some approaches used to measure permeability partially excluded this possibility by normalizing absorption of the inert sugar lactulose to that of the smaller, and more easily absorbed, inert sugar mannitol [17,18]. The implication that increased permeability in CD reflects abnormal tight junction permeability was supported by transmission and scanning electron microscopy studies showing a reduction in the number of tight junction contacts as well as disruption of the normal anastomosing strand pattern seen by freeze fracture electron microscopy [19,20]. Subsequent work showed that, in addition to being present in CD patients, increased paracellular permeability was also present in a subset of their healthy first-degree relatives [21,22]. This suggested that barrier defects could be a cause of CD [23,24], and more recent work has linked barrier defects in healthy relatives to specific mutations in NOD2/CARD15[25]. Unfortunately, the contribution of barrier defects to risk of developing disease in healthy relatives of CD patients has not been assessed. One case report has described a subject who had increased intestinal permeability at age 13, but no evidence of CD, and went on to develop disease 8 years later [26]. However, this patient had 2 first-degree relatives with CD and, therefore, was at increased risk of developing disease regardless of intestinal permeability. Nonetheless, this case does demonstrate a barrier defect prior to onset of CD and, therefore, supports the hypothesis that increased permeability may be an early step in the pathogenesis of this disorder.
Additional circumstantial evidence supporting a role for barrier defects in CD pathogenesis comes from a series of studies examining patients during remission. These analyses showed that patients with increased intestinal permeability were at greater risk of relapse over the subsequent year [27,28,29]. It should, however, be noted that one more recent study failed to reproduce these data [30]. In that study, reduced psychosocial stress correlated with decreased rates of relapse. The implications of this observation are of interest in terms of treatment and pathogenesis and may relate to barrier function, as stress can induce increases in small intestinal permeability [31]. Notably, the more recent work also identified the presence of colonic disease as an independent predictor of disease relapse [30]. This is particularly significant, since the probes used to assess permeability in that study, lactulose and mannitol, are degraded by colonic bacteria. Thus, an alternative explanation for the absence of a correlation between disease relapse and permeability in that study is that subclinical disease was present in the colon. The fact that lactulose and mannitol, as well as other commonly used paracellular probes, are degraded by colonic bacteria is the principle reason why the data above apply primarily to CD. However, it should be noted that some of the observations described above, included abnormal tight junction ultrastructure [32], have been demonstrated in ulcerative colitis. Further analysis of these issues in ulcerative colitis patients may now be possible, as newer probes able to assess colonic paracellular permeability have become available [33].
As mentioned above, tight junction structure and function are abnormal in CD and ulcerative colitis. Recent advances in our understanding of tight junction proteins components have made it possible to directly assess these events in human specimens. Remarkably, both epithelial cells from CD and ulcerative colitis patients demonstrate increased expression of claudin-2 [34,35]. Claudin-2 expression in cell culture models increases Na+ conductance across the tight junction and also increases the number of small tight junction pores [4,5,36]. However, this may not be sufficient to explain the increased permeability to lactulose seen in CD patients. One potential explanation for observed increases in permeability of lactulose and other large molecules may be the removal of claudin-5, claudin-8, and occludin from the tight junction as well as degradation of these proteins in CD patients [37]. However, it may also be that acute cytokine-dependent tight junction regulation plays a critical role. For example, the tumor necrosis factor (TNF)-neutralizing antibody infliximab, which is remarkably effective in CD and some ulcerative colitis patients [38,39,40], also restores the intestinal barrier in CD patients [41]. While these effects may be secondary effects of reduced inflammatory activity after infliximab treatment, a direct role of tumor necrosis in regulating barrier function must be considered.
TNF causes barrier loss in cultured intestinal epithelial monolayers [42,43]. Given the ability of infliximab to restore barrier function in human patients, the means by which TNF causes increased paracellular permeability is of considerable interest. A major advance in understanding this process came from the observation that myosin light chain kinase inhibition was able to acutely restore barrier function in TNF-treated intestinal epithelial monolayers [44]. In addition to providing insight into TNF-dependent tight junction regulation, this result suggests that the underlying mechanism may overlap with those responsible for physiological barrier regulation by Na+-nutrient cotransport, which also requires myosin light chain kinase activity [9]. Further studies showed that acute TNF treatment resulted in increased myosin light chain kinase expression [43,45], as a result of transcriptional activation [46], in vitro and in vivo. Consistent with a role in barrier loss in human disease, further study revealed increases in myosin light chain kinase expression and activity in intestinal epithelia from ulcerative colitis and CD patients [47]. Thus, it was hypothesized that TNF-dependent myosin light chain kinase activation might be a critical mechanism of barrier dysfunction in inflammatory bowel disease.
An in vivo model was required to better define the role of TNF in barrier loss and diarrheal disease. This model was established by treating mice with either an anti-CD3 monoclonal antibody, to activate T cells, or by injecting purified recombinant TNF [48,49,50]. These treatments cause an acute, self-limited diarrhea that can be prevented by infliximab [48,49]. Moreover, treatment of human subjects with anti-CD3 monoclonal antibody induces an acute, self-limited diarrhea that, like inflammatory bowel disease, can be treated with corticosteroids [51,52,53]. Thus, while the mouse model does not cause chronic disease, it has pathophysiological relevance to human inflammatory bowel disease.
T-cell activation induced increases in jejunal paracellular permeability within hours [49]. This was accompanied by jejunal epithelial myosin II regulatory light chain phosphorylation, consistent with myosin light chain kinase activation [49]. Moreover, myosin II regulatory light chain phosphorylation waxed and waned in parallel with the development and resolution of diarrhea and both phosphorylation and increased paracellular permeability were prevented by infliximab [49]. This suggested that TNF-dependent myosin light chain kinase activation might be required for in vivo barrier loss and diarrhea. To test this hypothesis, the response of mice lacking the long myosin light chain kinase [54], the only form expressed in intestinal epithelia [55], to T-cell activation was assessed. Mucosal cytokine production induced by T cell activation was similar in wild-type and long myosin light chain kinase knockout mice. However, intestinal epithelial myosin II regulatory light chain phosphorylation did not increase, there was no increase in paracellular permeability, and diarrhea was prevented [49]. In addition, the most prominent morphological correlate of tight junction dysregulation, endocytosis of the tight junction protein occludin, did not occur in long myosin light chain kinase knockout mice. Similarly, treatment of mice with a specific peptide inhibitor of myosin light chain kinase prevented myosin II regulatory light chain phosphorylation, occludin endocytosis, barrier loss, and diarrhea. Thus, the TNF-dependent diarrhea that occurs after T-cell activation requires long myosin light chain kinase-mediated myosin II regulatory light chain phosphorylation [56].
The data presented thus far demonstrate that (1) myosin light chain kinase activation is necessary for acute TNF-induced barrier loss and diarrhea, (2) myosin light chain kinase expression and activity are increased in inflammatory bowel disease patients, (3) barrier loss is present in some first-degree relatives of CD patients, and (4) barrier loss precedes and may be a marker of impending disease reactivation. In addition, in vitro work has shown that expression of a constitutively active truncated myosin light chain kinase in cultured intestinal epithelial monolayers is sufficient to increase tight junction permeability [57]. Thus, to test the hypothesis that increases in tight junction permeability, similar to those detected in CD patients and a subset of their relatives, a transgenic mouse expressing the constitutively active truncated myosin light chain kinase within the intestinal epithelium was developed [58]. As expected, this mouse displayed increased myosin II regulatory light chain phosphorylation within intestinal epithelia and increased paracellular permeability within the small intestine and colon [58]. However, the mice developed, gained weight, and reproduced normally under standard specific pathogen-free housing. While some might consider this to indicate that the model was poorly executed, the absence of spontaneous disease in these mice actually recapitulates human data. Healthy first-degree relatives of CD patients with increased permeability are notable because they are healthy; with no evidence of disease. Many of these relatives will never develop disease. Thus, the transgenic mice expressing constitutively active myosin light chain kinase represent a unique opportunity to probe the mechanisms that maintain mucosal homeostasis despite the presence of barrier defects and to ask if such defects predispose an individual to inflammatory bowel disease.
Detailed analysis of the constitutively active myosin light chain kinase transgenic mice showed that TNF, interferon-γ, and interleukin-10 expression were increased within the colonic mucosa [58]. Interestingly, these increases were not present prior to weaning, raising the possibility that the rapid changes in luminal microbiota composition that accompany weaning may contribute to the observed mucosal immune activation. The transgenic mice also demonstrated a marked increase in the number of lamina propria T cells and a repositioning of CDllc+ dendritic cells to a subepithelial location. It will be a great interest in the future to determine what immune mechanisms prevent disease in these mice.
To determine if increased intestinal paracellular permeability could contribute to disease progression, the transgenic mice were studied using the CD4+CD45Rbhi adoptive transfer model of colitis, which shares many biochemical, immune, and morphological characteristics of human inflammatory bowel disease [59,60,61,62]. When constitutively active myosin light chain kinase transgenic mice were challenged with CD4+CD45Rbhi T cells, they developed colitis more rapidly than their non-transgenic littermates. Weight loss occurred earlier, mucosal cytokine expression was higher, and histologic damage more advanced in the transgenic mice. As disease progressed, weight loss in transgenic mice and non-transgenic littermates became similar, but mucosal cytokine expression remained higher and histologic damage more severe in the transgenic mice. In addition, survival of transgenic mice was reduced relative to non-transgenic littermates. Thus, pathophysiologically relevant regulation of intestinal epithelial tight junctions induces mucosal immune activation and, while insufficient to cause disease, can contribute to development and progression of colitis.
The tight junction is a critical determinant of mucosal barrier function. In the absence of mucin deficiency or gross epithelial damage, the tight junction is the primary determinant of paracellular permeability. Increases in intestinal permeability are present in healthy individuals and have been reported at increased frequency in first-degree relatives of CD patients. A role of barrier loss in CD pathogenesis is further suggested by the observation that increased intestinal permeability correlates with increased risk of relapse from remission. Finally, studies using pre-clinical animal models have demonstrated that TNF induces cytoskeletally mediated tight junction dysregulation. Conversely, cytoskeletally mediated tight junction dysregulation is able to increase mucosal TNF production, suggesting the presence of a cycle linking immune activation and epithelial barrier dysfunction. These data suggest that restoration of the intestinal epithelial barrier is an appropriate therapeutic target that may be an effective, non-immunosuppressive means of achieving or maintaining disease remission.
Supported by the NIH (grants R01DK61931, R01DK68271, and P01DK67887) and a Research Fellowship Award from the Crohn's and Colitis Foundation of America sponsored by Laura McAteer Hoffman (to L. Shen).
Disclosure Statement
The authors declare that no financial or other conflict of interest exists in relation to the content of this article.
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


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Reinsurers like Munich Re and Swiss Re act as a backstop to insurance companies such as Allianz (), providing cover against big damages caused by air crashes or liability claims. This process can cost clients both time and money, so most International Collection Agencies work to gather all necessary documents – from contracts to order, invoices, and confirmations – in order to prove a debt's validity and speed the recovery of the money for their clients. Luxury cruise travel today is indeed much different of computer was once and those that haven't been through it should dash with their travel agent to e-book the vacation cabin. Wow…you've given a heck of a lot of great info for stuff that travel agents don't tell you.
Data is collected and provided to the insurance auditor by the company personnel. Make sure this amount matches up with the amount that is shown on the bill that comes from the providers office-if it doesn't-call the insurance before you pay!! Such a policy might be suitable for a policy holder who is paying off their mortgage in chunks year on year and who, for example, would have significantly less to pay off five years on. Payouts from an insurance policy taken out through the employer are not taxed if you paid the premiums with after-tax dollars. Customers making such a large financial commitment so far in advance of their holiday are reminded to take out travel insurance as soon as they book their trip rather than leaving it to the last minute, so they will have cover for cancellations due to unforeseen events, such as an illness. Normally, such conditions are specifically published for travel insurance cruises holidays and overseas voyages.
If you travel extensively or are a full-timer" a motorhome has more of what you are looking for. However, given the worldwide employment conditions they are unable to locate employment and in most cases they do not have access to the proper resources to contact companies on a worldwide basis. Determine your insurance needs: Before you can find the most affordable medical insurance, you need to understand how insurance policies work. If your policy doesn't cover it, you can look for policies including winter sports cover by selecting the option when getting a quote. One of the components is making sure the owner has the right car insurance suited for the type of operation they are involved in. The current TEP plans at Sprint cost US$8 per month and cover mechanical as well as accidental damage, loss or theft.
One of the main reasons is because it is not cost effective for mortgage lenders, insurance or leasing companies to have their own field reps in every single town or zip code in the United States. This is why when my travel agency Vacationkids recommends infants should have their own airlines seats instead of flying free as a lapchild , we're not trying to part you from your money, we're trying to make sure your baby stays safe. If you are a broker and are looking for insurance leads , then you have chosen the right place. If a person enrolls in a new group health insurance plan, they may be asked if they have any pre-existing conditions.
Budget flight companies offering unbelievably cheap deals are notorious for 'giving you what you payed for.' In other words, they often loose baggage, delay and even cancel flights. You can make up for lost time by making sure that you have insurance that covers any flight cancellations, which will reimburse you for your time and effort, also protecting you against having to sleep in the airport if your flight is canceled overnight. Being covered for medical expenses is probably the most important element of your policy.
Because insurance is something most people use only in emergencies, it's hard to imagine how this industry could be transformed by technology. Medical Assistance companies tied to your travel insurance are a first port of call and, if you are on an organised holiday, then the tour operator is likely to have a resident representative at the resort. There are many insurance companies which offer backpackers with range of cheap travel insurance policies and deals that can be customized to suit his needs and the type of holiday he desires. Rolf Potts did a great job in Vagabonding of justifying not just travel as a lifestyle, but also a lifestyle that makes travel a non-negotiable ingredient. When calling please quote your Prudential travel insurance policy number, which is shown on your policy schedule.
Falling sick when you step into a new atmosphere is not a crime but not investing any thought about an insurance in your travel checklist is a mistake. Some credit card companies also have specialist travel departments which not only give you travel discounts but also give you even better protection, i.e. better travel insurance and at a much lower cost. That policy will be expensive in comparison to other policies due to the addition of specialized clauses. Allianz Australia Insurance Limited ABN 15 000 122 850 AFS Licence No. 234708 is the general insurer except in respect of life insurance, in which case Allianz Australia Life Insurance Limited ABN 27 076 033 782 AFS Licence No. 296559 is the insurer. With a POS plan, the policy holder can elect to see a physician outside of the network and still receive some coverage while making a co-payment.
They should visit the websites exclusively created for this purpose and go through details of the policies, their quotes and other terms and condition. Some items hold their value really well and you actually won't be able to buy a replacement one for anywhere near the money the travel insurance company gives you. Most of the travel insurance will cover luggage theft, stolen cash and other belongings. The Association of British Insurers said that while the review looked at brokers and retailers rather than insurers, it raised important issues for the wider insurance market. Cover under the Amendment or Cancellation Costs Benefit begins from the time you buy your policy.
Once-a-year insurance plan for instance is a insurance policy that may be opened up as well as maintained quite easily without continual phone calls and time invested being concerned about discounts and short comings. Schengen Visa will allow anyone including Filipinos to travel and visit 22 European countries and 3 non-European in just one visa. The amount will vary from policy to policy therefore it is important to take note of the deductible which will have to be paid before the insurance company pays anything.
Also, I will help anyone that wants to find the cheapest hotel/flight/package deals (please include your travel dates and destinations), your answers for the cheapest deals will be posted on my blog. If you're having a difficult time doing insurance cold calling and you're an insurance agent on your own, I suggest you join another agency. I knew my bank cards were iffy concerning out of country purchases, even after informing them of my travel itenerary. The insurance company will usually make payment on your claims by employing one of two systems.
First party coverage covers you and your property (such as medical expenses, damage to your vehicle, and includes the insurance company's duty to defend you in the event that you are sued as the result of your operation of a vehicle, etc.) Third party coverage is for your responsibility to pay for injury caused to other people (and vice versa), whether in your vehicle, or another vehicle involved in the accident. Referring websites in order to choose the insurance company provides you some extra benefits also. Travelsafe Travel Insurance is a good option when you are leaving the country and are worried about medical coverage. I suggest it is better to get visa from a travel and let them do the rest and less hassle from your side. Add fresh, free web content to your site such as newest articles, web tools, and quotes with a single piece of code!
To help you in your search for a good car insurance provider, we've taken a quick look at AIG and Mercury insurance to see how they fare against other carriers. On the other hand, going by different insurance policies you can secure your money so that in any case if you have to cancel your trip your valuable investment will not be wasted. With on-demand economies growing in multiple sectors, having an insurance option that allows those people to pay for the insurance only when the need it is a great option to give great coverage, without spending any extra money.
AA Travel Insurance is a brand style of Automobile Association Insurance Services Limited (AAIS) used under licence by Cigna Insurance Services (Europe) Limited. It should be $50/month with a Debit to Insurance Expense and a Credit to Prepaid Insurance. Both of these insurance companies also procure travel agents when it comes to selling the travel insurance. It is always good to surf the internet and study the websites which have been created to provide information about holiday insurance UK. There are numbers of schemes or options offered by several insurance companies. Get a free quote today at good to go insurance and get the best ten deals to compare.
I stopped taking out travel insurance when I had 2 genuine robbery claims declined – well not declined but they wanted original reciepts for cameras Id owned for years! In fact, indirect costs usually include travel and accommodation, which are really expensive in a large city. Holiday travel insurance is useful when you meet with sudden emergency situations that cause personal loss and run up extra expenses in your travel destination. New immigrants to Canada are not eligible for provincial health insurance until they gain landed immigrant or permanent residence status.
Two of the most well known travel insurance companies are Access America and Travelsafe Travel Insurance. Inspector B Northrop Grumman – Sykesville, MD Must be willing to accept short-term field assignments up to 90 days which could require about 60% travel. If you receive a notice from your health insurance company indicating that there was an incorrect policy number, enrollee number, patient birth date, or no record of coverage" then the claim that your physician or healthcare provider sent to the insurance company did not accurately identify who you are. More importantly, the high end vehicle has a higher replacement cost and is more likely to be stolen. Other exclusions and conditions may apply so please check the Policy Wording for details.
Finally, the Affordable Care Act allows individuals to stay on a parent's health insurance plan until the age of 26, even if they're married, live in a different state, or aren't financially dependent on their parents in any other way. Europe Tour Package – Book Europe And Uk Tours & travel packages at MakeMyTrip. In fact, this type of insurance is best for people who are looking for budget insurance. Travel80® Term Travel Insurance is currently not available to residents of Quebec or New Brunswick. Some travel web sites will offer deals if you book your trip, such as discounts. By reading this article you can learn new ways to save money on your car insurance.
Veterinarian, animal groomer liability insurance provides coverage for the establishment for any bodily injuries and property damage that the mismanaged behaviors of the business or its staff cause to the public against certain risks. The United States Tour Operator Association and National Business Travel Association are two major professional associations that represent the industry. At Chill Insurance, we understand that travel can ignite many people's sense of adventure. Our growing team of experts have worked in R&D, Operations, and Quality Control for national retailers and CPG manufacturers, from fast-growing startups to Fortune 100 companies.


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Chapter 4
4:1 Then (tote) the (ho) Jesus (Iēsous), under (hupo) [authority, AE] of the (tou) Spirit (pneumatos), was led up (anēchthē) into (eis) the (tēn) desolate place (erēmon) to be tested (peirasthēnai) under (hupo) [authority, AE] of the (tou) diabolical one (diabolou).
4:2 And (kai) having fasted (nēsteusas) forty (tesserakonta) days (hēmeras) and (kai) nights (nuktas), he pined (epeinasen) later (husteron).
4:3 And (kai) the one (ho) testing (peirazōn) having come toward (proselthōn) [the Jesus, v1, RE], he enunciated (eipen) to him (autō), "If (ei) you are (ei) a son (huios) of the (tou) God (theou), enunciate (eipe) [you are a son, ER] in order that (hina) the (hoi) stones (lithoi), these ones (houtoi), may cause themselves to become (genōntai) loaves of bread (artoi)!"
4:4 But (de) the (ho) [Jesus, v1, RE] having been caused to make a decision (apokritheis), he enunciated (eipen), "It has been written (gegraptai), 'The (ho) mortal (anthrōpos) shall absolutely not cause himself to live (ouk zēsetai) upon (ep) bread (artō) alone (monō), BUT (all'), upon (epi) every (panti) statement (rhēmati) being caused to go out (ekporeuomenō) through (dia) a mouth (stomatos) of God (theou)!'"
(See Deut. 8:3; Mat. 4:4; Acts 1:16, 3:18, 21, 4:25; Heb. 1:1-2)
4:5 Then (tote) the (ho) diabolical one (diabolos) took him along (paralambanei auton) into (eis) the (tē) holy (hagian) city (polin) and (kai) stood (estēsen) him (auton) upon (epi) the (to) wing (pterugion) of the (tou) sacred place (hierou).
4:6 And (kai) says (legei) to him (autō), "If (ei) you are (ei) a son (huios) of the (tou) God (theou), throw (bale) yourself (seauton) down below (katō)!
Because (gar) it is written (gegraptai) that (hoti), 'He shall cause Himself to give an injunction (enteleitai) about (peri) you (sou), and (kai) the (tois) messengers (angelois) of Him (autou) shall lift (arousin) you (se) upon (epi) hands (cheirōn);
at no time (mēpote) may you strike (proskopsēs) the (ton) foot (poda) of you (sou) toward (pros) a stone (lithon).'"
(See Psalm 91:11-12)
4:7 The (ho) Jesus (Iēsous) shed light5346 (ephē) to him (autō), "Again (palin) it has been written (gegraptai), 'Absolutely do not test out (ouk ekpeiraseis) [the] Lord (kurion), the (ton) God (theon) of you (sou)!'"
(See Deut. 6:16)
4:8 Again (palin) the (ho) diabolical one (diabolos) takes him along (paralambanei auton) into (eis) a very greatly (lian) high (hupsēlon) mountain (oros).
And (kai) he thoroughly shows (deiknusin) to him (autō) all (pasas) the (tas) kingdoms (basileias) of the (tou) cosmos (kosmou), and (kai) the (tēn) glory (doxan) of them (autōn).
4:9 And (kai) he enunciated (eipen) to him (autō), "All (panta) these things (tauta) I shall give (dōsō) to you (soi), if perhaps (ean) falling4098 (pesōn) you may bow to4352 (proskunēsēs) me (moi)."
4:10 Then (tote) the (ho) Jesus (Iēsous) says (legei) to him (autō), "Get underway (hupage), Satan (Satana), because (gar) it has been written (gegraptai), 'You shall bow to4352 (proskunēseis) [the] Lord (kurion), the (ton) God (theon) of you (sou), and (kai) to Him (autō) alone (monō) you serve (latreuseis).'"
(See Deut. 6:13, 11:3-4)
4:11 Then (tote) the (ho) diabolical one (diabolos) let go (aphiēsin) of him (auton).
And (kai) behold (idou), messengers (angeloi) came to (prosēlthon) [him] and (kai) were ministering (diēkonoun) to him (autō)!
4:12 But (de) [the Jesus, v10] having heard (akousas) that (hoti) John (Iōannēs) was passed aside (paredothē), he made up room402 (anechōrēsen) into (eis) the (tēn) Galilee (Galilaian).
4:13 And (kai) having left (katalipōn) the (tēn) Nazareth (Nazara) he homed-down (katōkēsen) into (eis) Capernaum (Kapharnaoum), the one (tēn) alongside the sea (parathalassian), in (en) [the] boundaries (horiois) of Zabulon (Zaboulōn) and (kai) Nephthalim (Nephthalim);
4:14 in order that (hina) the (to) [prophecy, AE] having been stated (rhēthen) through (dia) the (tou) prophet (prophētou) Isaiah (Hsaiou) may be fulfilled (plērōthē), saying (legontos),
4:15 "Land (gē) of Zabulon (Zaboulōn), and (kai) land (gē) of Nephthalim (Nephthalim), way (hodon) of sea (thalassēs), [on the] other side (peran) of the (tou) Jordan (Iordanou), Galilee (Galilaia) of the (tōn) ethnic groups (ethnōn),
4:16 the (ho) people (laos), the one (ho) causing itself to sit down (kathēmenos) in (en) darkness (skotei), it saw (eiden) a great (mega) light (phōs).
And (kai) to the ones (tois) causing themselves to sit down (kathēmenois) in (en) [the] region (chōra) and (kai) shadow (skia) of death (thanatou), a light (phōs) rose up (aneteilen) for them (autois)."
(See Isaiah 9:1-2)
4:17 From (apo) then (tote) the (ho) Jesus (Iēosous) caused himself to start (ērxato) to preach (kērussein), and (kai) to say (legein), "Repent (metanoeite), because (gar) the (hē) Kingdom932 (basileia) of the (tōn) Heavens (ouranōn) has come near1448 (ēngiken)."
(As recorded in Mat. 3:2, John the Baptist preached that the Kingdom of the Heavens has come near (ēngiken), about two thousand years ago already! As recorded in Mat. 4:17, and in other passages, starting at the beginning of Jesus' earthly ministry, he also preached that the Kingdom of the Heavens / Kingdom of God has come near (ēngiken)!
Was the Kingdom of the Heavens / Kingdom of God as near to the believers about two thousand years ago as Judas was near to Jesus on that night, the night Judas walked up to Jesus and gave him a kiss (Luke 22:47)? For the meaning of the Greek word ēngiken, look up and read all of the passages where an inflected form of its root word ēngizō is used, searching on Strong's # 1448.
There's about 43 usages of ēngizō, in which all of their contexts they unanimously agree in the definition of the answer to the question of "How near is near?" In all of their contexts, the things which are said to have come near are literally near enough and close enough to immediately be touched and / or entered into and experienced.
Scripturally, ēngizō, meaning near, can't possibly mean "over two thousand years away into the future" as the present popular invented mortal-made theological theory insists. Something separated from something else by such a great distance in time (Acts 2:39), or geographically (Luke 15:13, 19:12), is the meaning of the Greek word makros, Strong's # 3117, meaning far off.
Jesus Christ and his disciples/apostles taught during the time of Jesus' earthly ministry, both before and after his resurrection, that the Kingdom of the Heavens / the Kingdom of God has come near, which means it can't possibly be near (ēngizō) and far off (makros) at the same time!
See Mat. 3:2, 4:17, 6:10, 10:7, 26:29; Mark 1:15, 9:1, 14:25, 43; Luke 10:9-11, *17:20-21, 19:12, 22:18, 47; Acts 2:39; 1 Cor. 6:12, 10:23, 11:25; Heb. 8:8, 9:15.)
4:18 But (de) walking around (peripatōn) alongside (para) of the (tēn) sea (thalassan) of the (tēs) Galilee (Galilaias) he saw (eiden) two (duo) brothers (adelphous):
Simon (Simōna), the one (ton) being said (legomenon) [to be] Peter (Petron), and (kai) Andrew (Andrean) the (ton) brother (adelphon) of him (autou), throwing (ballontas) a throw-around net (amphiblēstron) into (eis) the (tēn) sea (thalassan), because (gar) they were being (ēsan) fishermen (halieis).
4:19 And (kai) he says (legei) to them (autois), "[Come, Mat. 16:24; Luke 9:23; etc.] behind (opisō) me (mou), and (kai) I shall make (poiēsō) you (humas) fishermen (halieis) of mortals (anthrōpōn)."
4:20 But (de) the (hoi) [Peter and Andrew, v18] straightaway (eutheōs) having let go (aphentes) of the (ta) nets (diktua), they followed (ēkolouthēsan) him (autō).
4:21 And (kai) [the Jesus, v17] having progressed (probas) from there (ekeithen), he saw (eiden) two (duo) others (allous), brothers (adelphous);
James (Iakōbon), the (ton) [son] of the (tou) Zebedee (Zebedaiou), and (kai) John (Iōannēn) the (ton) brother (adelphon) of him (autou), in (en) the (tō) ship (ploiō) with (meta) Zebedee (Zebedaiou) the (tou) father (patros) of them (autōn), making fit (katartizontas) the (ta) nets (diktua) of them (autōn).
And (kai) he called them aloud (ekalesen autous).
4:22 But (de) the ones (hoi), straightaway (eutheōs) having let go (aphentes) of the (to) ship (ploion) and (kai) the (ton) father (patera) of them (autōn), they followed (ēkolouthēsan) him (autō).
4:23 And (kai) he was going around (periēgen) in (en) the (tēn) whole (holēn) of Galilee (Galilaia) teaching (didaskōn) in (en) the (tais) synagogues (sunagōgais) of them (autōn), and (kai) preaching (kērussōn) the (to) Evangelism (euangelion) of the (tēs) Kingdom932 (basileias), and (kai) giving therapy (therapeuōn) [for] every (pasan) sickness (noson) and (kai) every (pasan) malady (malakian) among (en) the (tō) people (laō).
4:24 And (kai) the (hē) [teaching and preaching, v23] heard (akoē) of him (autou) went away (apēlthen) into (eis) [the] whole (olēn) of the (tēn) Syria (Surian).
And (kai) they brought (prosenegkan) to him (autō) all (pantas) of the ones (tous) maliciously (kakōs) having (echontas) various (poikilais) sicknesses (nosois), and (kai) [of the ones] being held together with (sunechomenous) torments (basanois), and (kai) [of the ones] being demon-possessed (daimonizomenous), and (kai) [of the ones] being Moon-exercised (seleniazomenous), and (kai) [of the ones] paralyzed (paralutikous).
And (kai) of them (autous) he gave therapy (etherapeusen).
4:25 And (kai) many (polloi) crowds (ochloi) followed (ēkolouthēsan) him (autō) from (apo) the (tēs) Galilee (Galilaias), and (kai ) [from the] Decapolis (Dekapoleōs), and (kai) [from the] Jerusalem (Hierosolumōn), and (kai) [from the] Judaea (Ioudaias), and (kai) [from the] other side (peran) of the (tou) Jordan (Iordanou).


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