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Get to know our Board of Directors:
Rob O'Dea, Chair
Rob O'Dea is an accomplished executive with more than 16 years of experience in setting marketing, product, and communications strategy for blue chip clients. The early years of his career were spent helping large national banks set their retail strategies and guiding some of the nation's largest retailers and brands including Nike, Adidas, Target, Costco, and Sam's Club through the launch of cutting edge retail technologies. Rob has started multiple companies including his current marketing firm, Barracuda M.A.D., LLC; commercial investigations and security firm, SA Risk Management; and strategy consultancy Sage Allied, LLC that has successfully overseen the entitlement of more than a $1.1 billion dollars of new construction development since 2012. Rob is an avid cyclist, fly fisherman, and skier who lives in Boulder with his wife, Adria and their two children.
Lisa Hough, Vice Chair
Networking, mentoring and making connections are both business and passion for Lisa Hough. She has two decades of professional experience in a variety of government and public affairs capacities including expertise in policy development, community investment strategies, media relations, and trade association engagement. In addition, she's had extensive experience in crisis communications. Lisa has worked for a number of global companies with strong ties to Colorado in telecommunications and energy as well as experience with several environmental organizations such as the Natural Resources Defense Council. She's a graduate of Sturm College of Law at the University of Denver where she specialized in natural resources law and public interest programs. Lisa obtained her undergraduate degree from Duke University. She and her family live in Westminster and enjoy all the city has to offer from the extensive open space corridors to the beautiful golf courses. Her family first came to Butterfly Pavilion with their girls as young children, but have enjoyed re-experiencing the facility with teenage eyes these days!
Kevin Medina, Past Chair
Kevin Medina is a highly skilled executive with an impressive track record of building and managing profitable organizations from the ground up. He is the founder of four successful start-ups and is currently President of his latest venture, Denver Marketing Group. Kevin has always believed in community involvement. He has served on the Board of Directors for Court Appointed Special Advocates of Adams County (CASA) and the Metro North Chamber of Commerce. He currently serves on the Board of Directors for Wish of a Lifetime, where he was also the Board Chair in 2010. Kevin is a Colorado native; he has two daughters and holds a B.S. in marketing from the University of Colorado at Boulder, School of Business and Administration.
Richard Jarboe, Treasurer
Richard Jarboe retired in May 2012 after working for almost 30 years as a computer programmer for various Denver-area financial and manufacturing companies. Prior to that, Richard worked in the mining and metals industry in Colorado and Arizona for 15 years. Richard has been an active volunteer at Butterfly Pavilion since August of 1997, and currently serves as Chairman of the Volunteer Leadership Council. Richard is also an active volunteer at the Denver Museum of Nature and Science since November of 1994, working in the Prehistoric Journey and Space Odyssey permanent exhibits.
Richard is a graduate of the Colorado School of Mines with a degree of Metallurgical Engineering, and an MBA graduate of West Texas State University (now West Texas A&M University) with an emphasis in Data Processing. Richard served as a Lieutenant in the US Army Corps of Engineers from 1967 to 1969 with duty stations in Korea and West Point, NY.
Bob Briggs, Secretary
Bob Briggs was elected to Westminster City Council in November 2007 and was term limited in 2015. He is President of Briggs Enterprises that contracts with companies that have issues with local government and is the head cheerleader for Rocky Mountain Railroad Xpress, an effort to connect Wyoming and New Mexico with 110 mph rail service. Bob has served as an Adams County commissioner, a Director for the Regional Transportation District, and a Colorado State Representative. He is a member of the Westminster High School class of 1955, and Colorado State University classes of 1959 and 1961. Other past memberships include Westminster Jaycees president, 1964-1965; Westminster Chamber of Commerce charter chairman, 2013; Westminster Rotary Club president, 1978; Boy Scout Troop 324 scoutmaster, 1975-78; Valley District for the Boy Scouts chairman, 1980; Westminster Presbyterian Church, president of the corporation three times; Denver Regional Council of Governments Board of Directors, 1980-82; Westminster Open Space Advisory Board, charter member since 1987. Bob received the 2015 Pioneer Award from Butterfly Pavilion for his efforts supporting the Pavilions since 1993.
Faith Winter
Faith Winter is currently the Mayor Pro-Tem of Westminster, Executive Director of Emerge Colorado, and candidate for State House District 35. Faith has spent her entire career inspiring people to action, whether it is the thousands of women she trained to run for office at The White House Project, the young voters she turned out in 2004, or engaging her constituents on important issues facing Westminster. In 2004 Winter was named one of 30 people under 30 showing political leadership by the Youth Vote Coalition; in 2008 Winter was named one of the top ten most influential women in Denver by the Denver Examiner; in 2010 she was named Woman of the year by Colorado Business and Professional Women, northwest chapter; and in 2012 Winter was named one of the up and coming women leaders to watch by the Denver Post. Winter loves organizing because she believes the best way to create change is by building power through people. She has fun doing it, because a job isn't worth doing unless you laugh once in a while.
Michael Snider
Michael Snider is a partner with the law firm Davis Graham & Stubbs LLP in Denver, where his practice focuses on federal income tax planning. He regularly advises clients on the tax aspects of international investments, cross-border mergers and acquisitions, and international joint ventures. Prior to joining Davis Graham & Stubbs LLP, Michael was a partner in the Houston office of Baker & McKenzie LLP and served as Tax Counsel for Chevron Phillips Chemical Company LP in The Woodlands, Texas. Michael has been recognized as a leading tax advisor by the International Tax Review and as a Texas Rising Star® by Thomson Reuters. Michael received his law degree from the University of Colorado at Boulder and a Bachelor of Science in Geography from the University of Georgia. He also has a Masters of Law in Taxation from New York University.
Joel Cox
Joel Cox is the Director of Digital Strategy and Co-Founder of Strategus, a digital agency providing 'What's Next in Data-Driven Advertising'. Joel developed his first online business at the age of 20 and graduated from the University of Colorado at Boulder with a degree in marketing. Joel's background began with search optimization and after having been a member of the core team that developed and rolled out the nation's first publisher-owned ad network for Media News Group, Joel co-founded Strategus. Joel is Google Certified and fluent in all facets of digital advertising with a passion and emphasis on cutting-edge & innovative digital display tactics.
Jordan Alvillar
Jordan's main passion is bringing a voice to those in need. Because of this, Jordan finds immense joy in being involved in her community and causes she cares about. Jordan works at Pac/West, one of the strongest political public affairs firms in the western United States. At Pac/West, Jordan serves as an account manager and communications expert for an array of clients and issues. Prior to Pac/West, Jordan worked for the Girl Scouts of Colorado in Communications and Product Sales, solidifying her passion and interest in nonprofit management and operations. In addition to sitting on the Board of Directors for the Butterfly Pavilion, Jordan is a Board member for Denver Gay Professionals and Kids in Need of Dentistry (KIND). Born and raised in Grand Junction, Jordan believes in investing in key organizations that are meaningful to Colorado's legacy. Jordan received her bachelor's degree from Northern Arizona University in Advertising and a minor in Visual Communications.
Kenneth Monfort
Kenneth Monfort has been owner/Director at Monfort Companies since 2011 and has played an instrumental role in structuring the family's private investment office as well as the commercial real estate development business. In addition to a board seat with Butterfly Pavilion, Kenneth holds influential positions with the State Colorado Restaurant Association, National Western Stock Show, The Denver Athletic Club, Ballpark Neighborhood Association, and Downtown Denver Partnership. Kenneth has a Bachelor of Science degree in Finance & Real Estate from University of Denver.
Tisha Schuller
Tisha Schuller consults private clients from fortune-500 energy companies to non-profit environmental organizations in energy policy, business strategy, politics, and community engagement. She also serves as the Strategic Advisor for Stanford University's Natural Gas Initiative. In this role, she works with companies and stakeholders to interface with Stanford's diverse faculty conducting research in the areas of sustainable development, technology innovation, climate policy, and geopolitics. She conducts public speaking and consulting focused on deescalating the energy wars, understanding the polarized landscape, and navigating successful strategies. Tisha most recently worked as President & Chief Executive Officer of the Colorado Oil & Gas Association in one of the most dramatic and contentious times for energy development in Colorado's history. Prior to COGA, Ms. Schuller served as a Principal and Vice President with Tetra Tech, a national environmental consulting and engineering firm for 15 years. She has a B.S. in Earth Systems with an emphasis in Geology from Stanford University.


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text: But Why is a meme relating to nonsensical things, asked in the manner of Fluttershy sitting on a toilet, with the caption 'but why' in response to someone requesting the drawing on 4chan. It is still somewhat common to see, and has been extended to include numerous other ponies as well. Many unicorn and pegasus features of the pony are missing.


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Explore the best hiking trails near Saint Paul with hand-curated trail maps and driving directions as well as detailed reviews and photos from hikers, campers and nature lovers like you.
Terry P. on Harriet Island to Cherokee Bluffs
10 days ago
Trail up the Bluffs says it was closed, but lots of people walking it. I would not rate it hard either, maybe moderate. Although a lot is on sidewalks the last half, nice walk.
1 month ago
wonderful hiling trails
1 month ago
lovely shady trail..got beautiful deer photos.


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They will also be adding more prize if the giveaway entry hit every 100th! No kidding faster hit the link to take part now.


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The innate immune system is our first line of disease against infection and injury, and responsible for initiating inflammatory and immune responses to resolve infections and repair injured tissues. This review focuses on the Toll-like receptors (TLRs) of the innate immune system and their role in recognizing infection and injury, and regulating inflammatory responses in the kidney.
There is increasing data to support a role for TLRs in immune complex-mediated glomerulonephritis. TLR7 has emerged as a key regulator of autoantibody production in murine lupus nephritis. In addition, studies have implicated TLR recognition of endogenous molecules released during cellular necrosis as critical regulators of sterile inflammation and injury. Tonic interactions between TLRs and environmental agonists derived from commensal microbes and endogenous sources may also influence autoimmune disease and inflammatory disorders affecting the kidney.
Future studies to decipher the contribution of TLRs and other innate immune receptors in the regulation of inflammation, immune responses, and injury in the kidney will pave the way for novel therapeutic interventions.
Toll-like receptors (TLRs) are members of a growing family of innate immune receptors and the focus of this review. Innate immune receptors detect infection and regulate inflammatory and immune responses. This traditional view of innate immunity has been transformed by in-depth study over the past several years to reveal a much broader role for the innate immune system in regulating the interactions between the host and its environment.
For simplicity, we can divide the innate immune system's interaction with our environment into three classes (Fig. 1). The first is local recognition of infection and injury, in which local activation of innate immunity yields potent inflammatory responses and the initiation of immunity. The second class is systemic activation of innate immunity by infection or injury, which may indirectly affect the kidney through release of inflammatory mediators or the propagation of systemic diseases. The third class is homeostatic interactions between innate immune system and environmental stimuli. The innate immune system is constantly receiving input from our environment and these signals may influence self-nonself discrimination (allergic and autoimmune responses, and transplantation), as well as tissue healing and repair in response to injury.
Long-awaited breakthroughs in structural studies on TLRs have demonstrated the molecular details of how some agonists bind and activate TLRs [1–3]. Structures of the TLR2/TLR1 heterodimer with triacylated lipopeptide and TLR3 with double-stranded RNA demonstrate the precise nature of ligand-induced receptor dimerization that is required for activation [1,3]. Both the TLR3 and TLR2/1 agonists bind to specific sites and form a bridge between the receptors. This bridging interaction brings together the glycan-free surfaces of the TLRs, and the dimer is further stabilized by extensive intermolecular protein–protein interactions between the TLR molecules. The general model for TLR recognition of agonists that emerges from these studies is that the individual TLRs use diverse means of ligand binding and intermolecular interactions to form dimers that have similar quaternary structure, which properly aligns the cytoplasmic domains to initiate signal transduction.
The structure of the TLR4/myeloid differentiation factor 2 (MD-2) complex with eritoran, a synthetic antagonist of lipopolysaccharide (LPS), suggests that ligand-induced conformational changes may be an additional mechanism for ligand recognition [2]. In this structure, the four acyl chains of eritoran are tightly bound in the hyprophobic pocket of MD-2 and occupy greater than 90% of the pocket's surface. MD-2 is bound to TLR4, and there is no direct interaction between eritoran and TLR4. Because agonistic forms of LPS have upto six acyl chains, conformational changes in the MD-2 LPS complex are predicted to accommodate the additional acyl chains. It is possible that conformational differences between the MD-2/eritoran and MD-2/LPS complexes determine whether or not TLR4 dimerizes. Future structures with agonist forms of LPS should provide insight into the molecular mechanisms that induce TLR dimerization.
Exogenous TLR agonists access the kidney through two major routes: direct infection and via circulatory system. The best studied system of direct infection is urinary tract infection and pyelonephritis. Multiple TLRs contribute to the host innate immune response to urinary tract infection by Escherichia. coli, including TLR4, TLR5, and TLR11 [4]. These clever bugs also inject Toll-interleukin-1 receptor (TIR) domain containing proteins into host cells that interfere with TLR signaling and increase virulence [5]. Despite the convincing role of TLRs in mouse models of bacterial infection, less is known about the role for these receptors in human bacterial infections of the kidney. In fact, individuals with homozygous defects in MyD88 or interleukin-1 receptor-associated kinase 4 (IRAK4), essential signaling adaptors for TLR1, 2, 4, 5, 6, 7, 8, and 9 (Fig. 2), have no reported increase in urinary tract infections [6•]. Remarkably, these individuals primarily suffered from increased susceptibility to a narrow range of pyogenic bacterial infections, most commonly Streptococcus pneumoniae, Staphylococcus aureus, and Pseudomonas aeruginosa, and these infections were limited to childhood and early adolescence [6•, 7•]. Little is known about the role of innate immunity to polyoma virus, which has become a substantial problem in renal transplantation. One recent study on mice [8] demonstrated that MyD88 contributed to the development of long-lasting antibody-mediated immunity to polyoma. A better understanding of the role of innate immunity in controlling polyoma virus infection may lead to novel strategies to increase natural immunity to this virus and preserve renal function in kidney transplant and immunosuppressed patients.
TLR agonists may also be circulating in the blood free or as a component of immune complexes, which are then deposited in the kidneys, frequently glomeruli, causing local activation of the innate immune system. This model is mostly theoretical and although supported by circumstantial evidence, we still have very little evidence to support the deposition of TLR agonists in the kidney and whether such deposited TLR agonists contribute to kidney disease. For immune complex-mediated glomerulonephritis, there is evidence that viral agonists of TLRs may contribute to the immune complex-mediated glomerulonephritis. TLR3 mRNA is upregulated in glomerular mesangial cells in hepatitis C virus (HCV)-associated membranoproliferative glomerulonephritis [9], and TLR7 polymorphisms have been linked to chronic HCV infection [10]. In addition, HCV core and NS3 proteins have been reported to activate macrophages through TLR2 [11]. Thus, TLRs may recognize HCV in immune complexes and this could aggravate glomerulonephritis. In addition to HCV-associated glomerulonephritis, TLR agonists may also be components of other infection-associated glomerulonephritides such as postinfection glomerulonephritis and IgA nephropathy. Thus, local recognition of TLR agonists in immune deposits may affect the inflammatory activity of immune complex-mediated glomerulonephritis.
The contribution of local vs. systemic TLR recognition to disease progression has been technically difficult to differentiate in mouse models, and the experimental approach that has been most frequently relied upon to make this distinction is the generation of bone marrow chimeras. This strategy helps to define the contribution of hematopoietic cells and nonhematopoietic cells, but falls short of defining cell-type-specific contributions. The recent generation of inducible MyD88-deficient mice provides a new tool to evaluate the cell-type-specific responses of TLRs using the Cre-LoxP system [12•] and this should provide even more details about the precise role of intrinsic TLRs in the kidney.
Sterile injury provokes inflammation and this inflammatory response has several physiologic and pathologic outcomes. The inflammatory response to injury is critical for wound healing and repair, and defense against opportunistic pathogens. However, the resulting inflammation may also lead to excessive tissue destruction and impaired organ function. Rodent models of toxin and ischemia-induced renal injury have demonstrated that inflammation contributes to the development of renal failure [13,14]. What are the receptors and ligands that trigger inflammation in these settings of sterile kidney injury? Recent studies implicate TLR2 and TLR4 as key regulators of inflammation in ischemia/reperfusion injury (IRI), but the results are complex. TLR2-deficient mice were protected from IRI [15,16••] and using bone marrow chimeras, Leemans et al. [15] found that the TLR2 effect was mediated by nonhematopoietic cells. Shigeoka et al. [16••] tested MyD88-deficient mice, which were also protected from IRI, but surprisingly, the MyD88 effect was substantially less than that seen for TLR2-deficient mice. In contrast, Wu et al. [17••] demonstrate substantial protection from IRI in TLR4-deficient mice and MyD88-deficient mice. Yet another study by Pulskens et al. [18••] concludes that TLR4-deficient mice are protected from IRI, whereas MyD88-deficient mice and TIR domain-containing adapter-inducing IFN-β (TRIF)-deficient mice are not. This group also found that the TLR4 effect is mediated by nonhematopoietic cells [18••]. In summary, these studies have found that TLR2 and TLR4 contribute to inflammation and renal insufficiency in IRI, and when tested these effects are mediated by nonhematopoietic cells. However, the studies disagree about the contribution of MyD88, the primary signaling adaptor for TLRs (except TLR3, Fig. 2). Future studies will be needed to clarify the roles of TLRs and their signaling pathways in IRI. TLR4 expressed in nonhematopoietic cells has also been demonstrated to contribute to the inflammatory response and kidney injury secondary to cisplatin [19].
A large number of molecules have been implicated as endogenous agonists of TLRs (Table 1) [20–36], and some of these could possibly mediate IRI. Wu et al. [17••] looked for upregulation of candidate TLR4 agonists and discovered that high mobility group box 1 (HMGB1), biglycan, and hyaluronan were increased in the ischemic kidney. The ensuing model is that IRI produces endogenous TLR4 agonists that activate TLR4 expressed by resident kidney cells, leading to inflammation and renal dysfunction. Unfortunately, much of the data concerning endogenous agonists of TLRs are plagued with issues of contamination [24,37,38]. HMGB1 has been ascribed multiple mechanisms for activating TLRs, which include direct binding to TLR2 and TLR4 [30,39], binding cellular DNA to promote endocytosis by receptor for advanced glycation endproducts (RAGE) and TLR9 activation [40], and promoting CD14-dependent TLR4 recognition of LPS [41]. Recombinant biglycan activates TLR2 and TLR4 in vitro, and biglycan-deficient mice are protected from sepsis induced by LPS or yeast cell wall [42]. Biglycan has also been shown to bind tumor necrosis factor (TNF) and transforming growth factor-β (TGF-β) and this activity may be relevant in vivo. Future studies should elucidate the molecular mechanisms of TLR2 and TLR4 activation during ischemic or toxic kidney injury and the role of endogenous TLR agonist in vivo.
Systemic activation of the innate immune can affect the kidney in multiple ways; we will focus on two pathways. The first is innate immune system activation of B lymphocytes, leading to the production of autoantibodies and immune complex-mediated glomerulonephritis. The second is the exacerbation of preexisting kidney disease by TLR agonists. Most of these data stem from mouse models, which may provide some insight into human disease.
Mouse models and human genetic studies have provided additional evidence that innate immune system regulates autoantibody production, and in particular lupus autoantibodies and rheumatoid factor. The recent advances in our understanding of the roles of TLRs in systemic lupus erythematosus (SLE) have revealed the close link between the nature of autoantigens in lupus and the ligand specificity of the TLRs, namely TLR7 and TLR9. These findings also unveiled an imperfection in the innate immune system – innate discrimination of host from pathogen is not absolute. This is true in particular for the nucleic acid TLR agonists. Thus, dsRNA (TLR3), ssRNA (TLR7 and TLR8), and CpG DNA (TLR9) are not chemical structures that are unique to microbes. The ability to discriminate host nucleic acids from microbial nucleic acids appears to rely on a combination of properties, including sequence motifs, tertiary structure, chemical modifications (i.e. cytosine methylation), and the endosomal localization of these TLRs. TLR recognition of host nucleic acids may be a promiscuity that has been tolerated throughout evolution, because the selective advantage of pathogen detection outweighs the risk of autoantibody production.
Rheumatoid factor is a common component of cryoglobulins in mixed cryoglobulinemia, which can cause membranoproliferative glomerulonephritis and is a problematic manifestation of HCV infection. Elegant studies on a mouse model demonstrated that rheumatoid factor-producing B cells were elicited in extrafollicular sites by immune complexes that contain IgG and chromatin through a mechanism requiring surface IgM, TLR7, TLR9, and MyD88 [43••]. This generation of autoreactive rheumatoid factor-producing B cells did not require T-cell-specific signals [43••]. Thus, costimulation of autoreactive B cells by autoantigens, which are TLR agonists or associated with TLR agonists, may be a common mechanism for autoantibody production.
The role of innate immunity in lupus nephritis has been recently reviewed [44]. Both TLR7 and TLR9 have been implicated in autoantibody production in lupus, but recent studies on a murine lupus model (the MRL/Mplpr/lpr mouse) suggest that these receptors may have opposing roles [45]. TLR7-deficient mice did not produce anti-Smith or antiribonucleoprotein (RNP) antibodies and they were protected from lupus nephritis. In contrast, the TLR9-deficient mice did not make anti-DNA antibodies, but they had accelerated disease. Duplication of the TLR7 gene in Yaa mice was responsible for their lupus phenotype [46,47] and TLR7 was also required for the mouse model of pristine-induced lupus nephritis [48,49]. Thus, there is substantial evidence that copies of TLR7 or excess production of endogenous TLR7 agonists contribute to lupus nephritis in the mouse. Overexpression of TLR4 in mice also resulted in autoantibodies and lupus-like nephritis in C57BL/6 mice [50]. In addition, deletion of single Ig interleukin-1 receptor-related molecule (SIGIRR), a negative regulator of TLR signaling (Fig. 2), exacerbated lupus in mice [51]. These studies support a role for dysregulation of TLRs (or their agonists) in lupus and have uncovered a surprising protective role for TLR9.
The models of nephrotoxic serum-induced glomerulonephritis, membranoproliferative glomerulonephritis, in the mouse suggest that systemic activation of the innate immune system can increase inflammation and injury within the kidney. Passive transfer of antiglomerular basement membrane (GBM) antibodies induced only mild disease, which is markedly exacerbated by coadministration of TLR agonists [52]. Similarly, TLR9 agonists augmented glomerular inflammation in a mouse model of membranoproliferative glomerulonephritis [53]. These studies suggest that systemic activation of the innate immune system can aggravate preexisting kidney disease.
The interaction between host and commensals is another area that has emerged in recent years as an important aspect of innate immunity. A seminal study [54] demonstrated that TLR-dependent sensing of commensal bacteria in the gut is critical for epithelial repair to toxic injury induced by dextran sodium sulfate. This study demonstrated that TLRs can sense commensal bacteria and use this as a signal to initiate wound healing and repair. More recent studies have illuminated the continuous interaction between our innate immune system and the environment. Mice that are deficient in TNFAIP3 (Fig. 2), a key negative regulator of TLR signaling, develop a spontaneous autoinflammatory disorder that involves multiple organs, including the kidney, and results in marked cachexia and early death [55]. This autoinflammatory disorder is dependent on MyD88 and commensal bacteria [56•], suggesting that tonic recognition of commensals by TLRs is kept in check by negative regulatory mechanisms. Human polymorphisms in TNFAIP3 have also been associated with SLE [57]. Interestingly, the increased anti-dsDNA antibody titer in TLR4-overexpressing mice was dependent on commensal flora [50]. In humans, MyD88 and IRAK4 are required for the efficient removal of autoreactive B cells [58••]. Finally, the development of diabetes in the nonobese diabetic (NOD) mouse was also influenced by MyD88 [59]. Thus, the development of autoantibodies and autoimmune diseases may in part be influenced by homeostatic interactions between TLRs and our environment, in particular commensal microbes and endogenous agonists. It is interesting to speculate that homeostatic interactions between TLRs and our environment are continuously regulating our inflammatory rheostat and self-nonself discrimination.
Microbial infections are also recognized by additional families of innate immune receptors, which are increasingly recognized as important components of the innate immune response. These families include the NOD-like receptors (NLRs) and the retinoic acid-inducible gene (RIG)-like helicases (RLHs) [60,61]. These families of receptors primarily detect microbial products that gain access to the cytosol, or alterations in host cell, such as the efflux of potassium. Importantly, extracellular ATP, uric acid crystals, and calcium phosphate crystals have been shown to activate the caspase-1 inflammasome and interleukin-1B and interleukin-18 secretion through an NLR-dependent pathway [62,63]. Future studies concerning these families of innate immune receptors should provide additional insight into the role of the innate immune system in recognizing infection and injury and regulating inflammation in kidney diseases.
These recent studies underscore the importance of the innate immune system in kidney disease. A more detailed understanding of the role of the innate immune system in sterile injury will help to clarify the receptors, signaling pathways, and agonists that regulate this response. There are also potential roles for modulating the innate immune system to promote the clearance of unwanted infections, such as polyoma virus infection, and to modulate tissue repair due to injury. Finally, we are now beginning to appreciate the existence of tonic signaling through TLRs via ligands that emanate from commensal bacteria or endogenous molecules, and that dysregulation of this homeostasis can influence inflammatory and autoimmune diseases. Future studies to decipher the contribution of TLRs and other innate immune receptors in the regulation of inflammation, immune responses, and injury in the kidney will pave the way for novel therapeutic interventions.
K.D.S. is supported by grants from the US National Institutes of Health.
Papers of particular interest, published within the annual period of review, have been highlighted as:
• of special interest
•• of outstanding interest
Additional references related to this topic can also be found in the Current World Literature section in this issue (pp. 000–000).
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


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Frequently Asked Questions
Other efforts to improve ACP include engagement programs; paper, video and electronic decision-aids; and skills training programs that focus on one stage of planning. Some of these efforts are complementary to and can be used to support the RC approach. Some are fundamentally inconsistent in their design and approach or are simply designed to be used themselves and cannot be integrated into the RC model.
No. The Respecting Choices program does not endorse or support groups or organizations.
No. Respecting Choices does not lobby or advocate for any legislation. The mission of RC is to help health organizations, professional societies and other groups build effective ACP systems so that patients and their families or loved ones can make the most informed, ethical decisions supported by medical science and permitted by law.
Respecting Choices believes that all patients and their families deserve accessible, highly quality ACP services. Experience and evidence have clearly led to the conclusion that physicians simply do not have the time to provide a service that typically can take 30 to 90 minutes depending on the patient and the stage of planning. Physicians are trying to address the needs of many patients and, clearly, treating the ill always needs to be a priority.
The physician does have a key role as a member of the ACP team. Advance care planning needs to be a team effort where ACP facilitators guide people through this complex conversation and call on the expertise of others, including physicians when needed.
Physicians also have an important role to initiate conversations, to motivate their patients to plan, to provide medical information as needed, to review plans over time so they stay up-to-date and become more specific as illness progresses and to use plans to make decisions when appropriate.
There is no formal programmatic or organizational relationship between the Physician Orders for Life-Sustaining Treatment (POLST) paradigm program or Task Force and Respecting Choices (RC). Early on, RC saw that the POLST system was an effective way to communicate important medical decisions for patients in the last year of life. It is a system that allows any medical decisions to be expressed and clearly communicated from one setting to another.
Additionally, the POLST program provides for revision and reconsideration of these decisions as health conditions change and transition of care occurs. The POLST paradigm has also been strongly supported by research evidence and has been endorsed by both professional groups and through legislation in 22 states. It was the clear effectiveness and systematic nature of the POLST paradigm that made it so consistent with the evidence-based, systematic approach of Respecting Choices.
Respecting Choices brings an expanded component to the POLST program: an effective method to train health professionals to facilitate the conversation with patients and their surrogates to enhance the quality of decision making. It was to achieve that end that RC developed the Last Steps® Advance Care Planning (ACP) facilitator, instructor, and faculty training program. The facilitated process can be used with any system of communication or documentation. POLST is the one that is most well-known and best supported by the evidence.
No. The aim of RC is to help establish effective ACP systems so all individuals have the opportunity to plan for certain future medical situations and to have their values and goals respected if a time comes when the person can no longer speak for himself or herself.
Use of the RC model appears to be associated with a lower utilization of acute care services because most individuals who effectively plan are interested in defining the boundaries of treatment when burdens outweigh benefits.
There is no truth to the claims that suggested the federal government would attempt to ration care by making ACP a benefit for Medicare members.
The link that was made between rationing and ACP occurred because the original healthcare reform act proposed a requirement that health organizations report three things:
Some political leaders incorrectly linked these outcome measures as "pay for performance" and argued that the goal was to pay physicians to talk patients out of expensive medical care. This allegation was not true.
The goal of outcome measures is to hold healthcare organizations accountable to use advance directives correctly. There is no reason to make ACP a benefit if this activity does not actually help improve care for patients and families. Paying clinicians to have ACP discussions makes no sense if the prevalence did not increase, plans were not available, and plans were not honored.
No. Rationing care means an effective medical treatment will not be provided because the treatment has been determined too costly. In some countries this is a social decision sanctioned after political debate and decision making.
Respecting Choices is an approach to assist people and those close to them to consider when the goals of medical care should or should not shift because of changing evaluation of the benefits and burdens of treatment. Respecting Choices is focused on assisting individuals and their families to make informed decisions about their future healthcare.
Effective ACP can lead to lower healthcare cost as it becomes possible to avoid treatments that are neither wanted by the patient or effective in treating the patient. If cost saving is achieved in this manner, it is because the patient's values and views have determined that the burdens of some medical treatment is not worth the potential benefits.
The RC approach with patients does not lead to earlier deaths. In one randomized, controlled clinical trial where patients were either provided RC ACP facilitation or a standard of care with no ACP intervention, subjects who received the RC facilitation and those who did not lived the same length of life. However, the intervention group received significantly less ICU care.
In La Crosse County where RC has been the standard of care since 1993, the mean age of death has increased over the past 20 years and is similar to the mean age of death as other counties in Wisconsin were ACP is not as widespread.
According to the Dartmouth Atlas, the La Crosse health region uses a very low intensity of hospital services in the last two years of life compared to other places. So while La Crosse has done better than almost every other place in the country to control healthcare cost, our citizens enjoy the same or longer lengths of life as in other areas of the country.
Respecting Choices and palliative care have some overlapping features, but are distinct. Palliative care clearly focuses on making important decisions with patients about their care, especially those who have serious illnesses.
Respecting Choices also helps address these issues; however, RC addresses a broader range of ACP activities including planning at a time when people are healthy and are preparing for some unexpected, serious illness.
Because of its person-centered approach, fostering concurrent care and its team approach, RC does foster a palliative approach to all patient care and extends the benefits of palliative care to a much broader number of patients.
Clearly, it is impossible and would be dangerous to plan for everything that might afflict a human being. Fortunately, it is not necessary to attempt such planning. When planning is conceived as something that can be done over time and in relationship to your health condition, it becomes possible to create a more realistic planning experience.
When adults are healthy or don't have a progressive, life-limiting condition, there are only two important future medical decisions that are needed:
With this approach to planning individuals can express a plan (e.g., who will make your decisions when you cannot and when a serious brain injury would be so bad that the goals of medical treatment should change). In making this plan the person can indicate what treatment might be forgone, but the actual decision would be made in the moment by the appointed healthcare agent.
This First Steps® plan needs to be reviewed and reconsidered over time, but people really do not have to plan for any other medical decisions until they have a serious condition that is getting worse, and/or they are suffering significant or more frequent complications.
At this point in time it is clear that more complications might be expected. Here, what we need to be prepared for is how to proceed when we treat the next complication and the outcome of that treatment is not good. When would an outcome be so bad that you might change the goals of care? Again such planning prepares the patient or the healthcare agent to actually make medical decisions in the moment.
Of course the answer for some individuals might be they "never" want the goals of treatment to change, but this is at least the type of circumstance where some bad outcomes would be viewed as low benefit and high burden for some individuals and this person may be too ill to communicate that assessment at the time needed.
Finally, when an individual has a short life expectancy and is getting worse despite treatments, people should have an opportunity to create a specific medical plan for if and when hospital services such as intensive care and mechanical breathing may be needed. These services will clearly be issues in the near future and might add little to such individuals' care—except prolong suffering.
The word "choices" in the name Respecting Choices is sometimes mistakenly thought to promote an unlimited personal autonomy, (i.e., whatever the patients wants is ethically, medically and legally acceptable). This has never been the aim of the RC program. In the end, of course, choices must be made and they must be guided by ethical and medical thoughtfulness within social and legal boundaries.
The word "choices" is plural not because each individual makes numerous decisions, but because plans reflect values and thoughts of patients, their families and the healthcare professionals who care for them. In these relationships it is the goal that all "choices" need to be respected.
Many approaches to planning are created to assist in planning by providing more information and by asking basic, straightforward questions for the individual to answer about their values and priorities.
While good information is always needed, one can only make authentic decisions if one's values and goals are clear and thought out. The questions that are often provided in decisions aids assume that it is relatively straightforward for individuals to answer and know the answers to these questions. Often this is not true!
Respecting Choices views the planning process as more complex and challenging. What's important and has priority at some future time isn't a process most are familiar with nor is it easy to sort these values and priorities out. Taking this to heart, RC has created a process of planning that includes the following focuses:


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Books in the Library
Docie, R. L. (2010). The inventor's bible: How to market and license your brilliant ideas. Berkeley, Calif: Ten Speed Press. Law Library, Call no.
Fox, B. (2009). Patents: A guide. Ormond, Vic: Hybrid Publishers. Law Library, Call no. 346.940486/F791p/2009
Ma, M. Y. (2009). Fundamentals of patenting and licensing for scientists and engineers. Hackensack, NJ: World Scientific. Dixson Library, Call no.
Park, J. H. (2010). Patents and industry standards. Northampton, Mass: Edward Elgar. Law Library, Call no. 346.0486/P235p


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View from Beeston Castle, Cheshire, England.
Bollington, Cheshire,UK.
English countryside. This looks like the kind of scenic view romance novels are written for.
Wentworth, Yorkshire, England
just love the low form factor grass in the foreground, not a mondo grass, but some form of low ground cover, looks great. adds a manicured, luxury style
reignandhale: bristol continues to amaze me
Castle Combe, England. Known for its picturesque scenery, the village in Britain's Wiltshire County about 20 miles east of Bristol was named the country's prettiest village...
7b2b28391d7fb06a5e42e053aca4cb8a.jpg (500×5485)
#StopTheHate they haven't done a single thing to deserve hate all that they have done is go on tour and sing for all of their fan's that they love very much and get to go all around the world and visit places they haven't been to ever.They even went to Africa to visit kid's who were sick and raise money for them and it was hard for them to see them like this and they cared about those kids and they care about their jobs and haven't done a single thing one so #NoHate
so guys whats your favorite songs off of four? i absolutely love no control with stockholm syndrome closely following. :) xx


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Team: Sophie
Raised in less-than-mainstream ways, Sophie has always been immersed in some form of outdoor pursuit. She sailed the seven seas as a youngster before taking to the land. Sophie's father would take her to Woodhill Forest to ride bikes, her mother to ride horses. Gradually the horses took over, but while studying Zoology and Marine Science in Dunedin, Sophie rekindled the old love for bikes. Nowadays, Sophie bikes for sustainable and affordable transport as well as for mountain adventures. At Bicycle Junction, she can typically be found curing caffeine cravings and talking bikes, bits, bobs, and other irrelevant banter.


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Summer Bird Travels Potluck Dinner & Program!
Thursday, September 26th, 2013
Dinner & Social at 6:30 p.m. with Program at 7 p.m.*
*Starts ½ hour early
Historic Amtrak Station, 918 Railroad Avenue
Our first program in September features our traditional covered dish dinner and presentations on the summer travels of chapter members. Bring your favorite dish to enjoy with other bird-minded folks and hear about the summer activities of friends and neighbors as well as plans for the upcoming year.
If you have 3-5 slides of your summer adventures with birds, please bring them along in a PowerPoint presentation and we'll let you take the stage to share the memories with other chapter members.
Apalachee Audubon's Education Committee Co-Chairs Carol Franchi and Pat Press spent a week at Audubon's Hog Island Education Camp in Maine this past summer and will share their experience with colorful slides and information on some of the stellar education materials being developed by Audubon.
Past-President Kathleen Carr and photo whiz Nick Baldwin also visited Hog Island this summer and have brought back some beautiful shots of puffins, gannets, and other cool-water species that stand to lose greatly as global warming progresses.


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day "I forget"....whose counting?
hahahaha...how pitiful is that, I can't even count how many days its been, and actually I suppose I could but I'm not goonna...cuz I don't care.....its Monday AM - time to get out and do my second open water dive test today. yesterday went out the the Great Barrier Reef and did two dives. Its like swimming in a big aquarium without glass walls. The seas were pretty rough....so folks got sick.....and it was certainly a new experience for me. the swells got pretty serious towards the end of the trip....and on the trip home (about 1.5 hours), it was a trip for sure. Sea spray everywhere! The diving was spectacular. Nemos everywhere. ok ok...clown fish. and so so so so many others. I will have to learn all the names. Potato Cod....big friggin ugly looking grouper kinda thing....about the size of a person. Giant clams.....huge....and I mean huge! anyhow....I've been told that the expedition that I am going on is likely one of the best in Australia, and the places we will go ar one of the best dive experiences in the world! So for now...I should get my ass in gear and head out. I'll have two days of rest before going out on my liveaboard boat expedition, and will take dsome time them to hopeful.y post some pics and write a little more. So far so good. The sun is hugley powerful...yes I got burned...a little. The temps are in the 80's including the water. the beaches are priceless....as is all the scenery so far! cheers all!


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I'm amazed it's December now and I'm marvelling how my last post was about Thanksgiving and we're now verging on Christmas.
I'm in holiday mode and there's been lots of holiday preparations the past 2 weeks...
: : some Christmas tree trimming
: : some handmade advent calendar surprises
: : and more tree trimming... (K's first Hello Kitty ornament from day 1 of the advent calendar)
: : And lots of Christmas cookie goodness!
K's is in love with cupcakes these days. All she wants to wear is clothes with cupcakes on them! I picked up the apron from Snug as a Bug at the One of a Kind Show a few weeks ago. Wishing you all a happy and cheerful holiday season!


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Saturday, May 14, 2011
Easter Egg Hunt
We had a Primary activity at our villa just before Easter. The children loved the easter egg hunt. Many of the children had never been to an easter egg hunt before. Our Primary is very diverse. We have Brazilians, Indians, Omanis, Americans, Filipinos, and Brits in our Primary. Along with all of the nationalities there are many different languages spoken. The one common denominator is the Primary songs and thus we do a lot of singing!
Mary Davis Family at 8:05 PM


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Marthas Vineyard, Massachusetts
From lush tree covered mountain ranges to the picturesque sand dunes of the coast, Massachusetts is a state that does not disappoint any visitor. From hikers and campers to history and ghost enthusiasts, the entire state is a theme park of life no matter what the interest is!
Martha's Vineyard
The 87 square mile land mass of Martha's Vineyard is primarily known as a summer colony, and is accessible only by boat and by air. Cost of living on the island is approximately 60% higher than the national average and housing prices are about 96% higher.
Although not a single's destination like Provincetown, upscale and gay-friendly Martha's Vineyard shouldn't be missed for a scenic and romantic getaway. Besides, it's home to the Dike Bridge and Gay Head Cliffs...
To find out more LGBT fun in Massachusetts, we recommend:
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text: Automotive Archive By AdminCategory AutomotiveAugust 15, 2017 The Best Jointer Planer in Review 2017 Generally, to make sure that you get the right product for your operational purposes, it is important that you gain a good understanding over the potential attributes that the product provides in comparison to the actual jobs Read More By AdminCategory AutomotiveAugust 6, 2017 The Best Portable Tire Inflator in Review 2017 It is better to own a portable tire inflator at home. Since flat tire might cause you time and budget, an immediate solution can be found with a purchase of tire inflator. The varieties of such tool Read More By AdminCategory AutomotiveJuly 28, 2017 The Best Roof Rack Basket in Review 2017 For this post, it is reviewing the best roof rack basket for you. 10 of the best of them have been first carefully selected through the customer review rate as well as its brand and quality. Along Read More By AdminCategory AutomotiveJuly 19, 2017 The Best Travel Trailer Covers in Review 2017 Of course, to take care of your travel trailer well, you need a good cover for it. Thus, it could stand again rain and sunlight better. Actually, quite a lot of the covers are available. It is Read More By AdminCategory AutomotiveJuly 18, 2017 The Best Thule Cargo Box in Review 2017 When it comes to needing the cargo box, you might think of which brand that is popular and will have the best product for you. According to our search, Thule is one of them you can trust, Read More By AdminCategory AutomotiveJuly 17, 2017 The Best Weight Distribution Hitch in Review 2017 Actually, not many weight distribution hitches are available on the market. However, the tool is extremely important that you have to need one if your work involves that. Still, a few of the available ones are best Read More By AdminCategory AutomotiveJuly 16, 2017 The Headache Rack in Review 2017 Not many best headache racks are actually available online. Still, among those that are available, some of them are brilliant for the design as well as the quality and strength. As reviewed by our team, these ten Read More


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I love hearing from readers, and I make every effort to respond to all fan mail in a timely fashion. For all requests, including charitable contributions, swag, interviews, and guest blogs, please contact my assistant, Melissa Jolly at Author Rx. She handles all my scheduling.
Send fanmail: E-mail • Tumblr • Good Reads • Facebook • Twitter


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Tax the wealthy to reduce national debt
What will we do if the national debt becomes so big that other countries stop lending to us?
Eliminate fossil fuel use to save environment
Another day of stifling heat is made even harder to bear thanks to the smoke filling the air.
Don't we have a weed law in Sunnyside?
As a resident of Sunnyside, I am concerned with all the dried weeds all over town.
Don't gut Johnson Amendment
If House Republicans succeed in their efforts to gut the Johnson Amendment, it would open the door for big money donors and political interest groups to pressure and manipulate our nation's churches and charities.
Cicada killers are beneficial, but sting
I am looking at an image on the front page of the July 18 issue of The Daily Sun taken by Ted Escobar.
Tell senators to vote no on Obamacare repeal
"The Better Care Reconciliation Act" is a cruel proposal.
Congressional oversight needed
In order to make the Ground-based Missile Defense System effective against attacks by North Korea or whomever, we should probably have rigorous congressional oversight (as well as any extra funding that is needed).
Repent if you want to go to heaven
America and the world continues down the path to impending destruction because of man's failure to follow God's word, rules and laws he set forth by which man was to live by.
Beware politicians giving away freebies
Dr. Carl Olden said, "The U.S. Senate worked behind closed doors to draft legislation that could change the future of health care in America."
Not an act of nature
In late February and early March, a berm protecting a 187-acre dairy-owned field near Outlook failed.
Action needed on carbon emissions
Freedom, a cherished value in America, is threatened by inaction on climate change.
Scholarship effort praised by reader
Wow — $16,000 for student medical scholarships raised by Charlene Maling and all her volunteer women and men managing the Sunnyside Community Hospital gift shop, part of the hospital auxiliary's projects of community support.
Port of Sunnyside work noticed
What a wonderful vision the Port of Sunnyside has for our city.
Florida reader calls for summer water safety
With summer here it's time to enjoy swimming with the grandkids, but you need to be aware of two rare and silent killers called dry drowning and delayed drowning.
Newspaper should be more positive
As a subscriber of The Daily Sun, I look forward to two papers every year the most — the babies edition and the Top 5 percent graduates.
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Dr. Kristophe Karami DO, MS Patient Reviews
- Neurological Surgery Vancouver, WA
Overall Rating
7 Patient Reviews
- Friendly Staff
- Promptness
- Appropriate Followup
- Spends Time With Patients
- Bedside Manner
- Fair and Accurate Diagnosis
- Easy Appointments
- Wait Time 10 minutes
Showing 1 - 7 reviews
1.0 of 5
January 27th, 2015
Trips over his own ego.
5.0 of 5
September 8th, 2013
A Beacon
My experience with Dr. Karami occurred during his tenure at Johns Hopkins. His professional skills and abilities, mannerism, and empathetic nature were traits that I found remarkable in this day and age where there is typically an aloofness between doctors of his caliber and their patients. In addition to his medical astuteness, he possesses impeccable bedside manners, is very through and patient--takes the time to answer questions/concerns and give detailed explanations of what's involved and the medical approach he will undertake. He performed two very intricate cancer surgeries on my husband in 2012 and I appreciated how he took the time to listen to my husband's fears, concerns, as well as, what I would classify as his frivolous gaffs. My husband had immense faith in Dr. Karami's medical abilities (that is second to God), and so did I. To sum up his personality: caring, down-to-earth and affable. KEEP UP THE GOOD WORK DOC AND CONTINUE TO BE TRUE TO WHO YOU ARE!! Thank you for all you have done and your support and empathy during our ordeal.
1.0 of 5
August 12th, 2017
1.0 of 5
August 12th, 2017
3.7 of 5
July 8th, 2014
5.0 of 5
May 12th, 2009
5.0 of 5
April 29th, 2008
Health Guides
Alzheimer's Disease
Get the facts about Alzheimer's Disease, including the symptoms and stages.
more health guides
Nearby Doctors
Dr. Kristophe Karami, DO, MS is similar to these 3 Doctors near Vancouver, WA.
Vancouver, WA
Vancouver, WA


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I went crazy and ordered a bunch of pens on Amazon. Collecting pens has been a hobby for a very long time. I got three different types… 150 more words
Tags » Sharpie Pen
Pen review
Sharpie happy team of Radiation Therapy Nurses.
I was always told not to write on myself or the ink will poison my blood and I would get really sick. Uhm…no one seems to have told my team of Radiation Therapy Nurses. 435 more words
"Expecto Patronum," by Zoe S.
"Expecto Patronum," by Zoe S. was done with sharpie marker and white gel pen.
"Hipster Green," by Zoe S.
"Hipster Green," was done with white gel pen, dual tip artists markers, and Sharpie pen. 6 more words
Sharpie pens on glass
Use silver and gold Sharpie paint pens to make our Christmas glasses this holiday season! 20 more words
A Junky Free Table on The Side of The Road...
So, if you're prone to reading this blog, be patient. It's going to take me a while to figure out the hang of it AND get in the groove, but I shall persevere! 820 more words
*Updated* Sharpies: Good for Writing, Great for Accessorizing
Editor's Note: This post is an updated version of the post titled "Permanent Fixtures: Reviewing the Sharpie" that was published on The Pensive Penner on September 13, 2016. 806 more words


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This award carries a $5,000 discretionary academic support prize given to the faculty member or group.
There is a two-stage selection process. The selection committee reviews the nominations and provides a list of potential awardees to the Dean of the Medical School, who makes the final selection. Nominees must be faculty of the University of Michigan Medical School.
Nominations for the Clinical and Health Services Research Award can be made using the Medical School's Competition Space website.
The nomination deadline is Monday, May 1, 2017.
2016 Recipients
John Z. Ayanian, M.D., MPP, Alice Hamilton Collegiate Professor of Medicine, professor, Department of Internal Medicine. Photo 1 | Photo 2
Ella A. Kazerooni, M.D., M.S., professor, Department of Radiology. Photo 1 | Photo 2
Past Award Winners
2015: Julie C. Lumeng, M.D., Albert P. Rocchini, M.D. & Sanjay K. Saint, M.D., M.P.H.
2014: Lewis B. Morgenstern, M.D. & Moshe Talpaz, M.D. and David C. Smith, M.D.
2013: Denise G. Tate, Ph.D. & John T. Wei, M.D., M.S.
2012: Steven J. Katz, M.D., M.P.H. & Maha Hussain, M.D., F.A.C.P.
2011: Ronald D. Chervin, M.D., M.S. & Eve A. Kerr, M.D., M.P.H.
2010: James T. Elder, M.D., Ph.D.
2009: Frederic C. Blow, Ph.D.
2008: Kevin Chung, M.D.
2007: A. Mark Fendrick, M.D. & William H. Herman, M.D., MPH.
2006: Laurence H. Baker, D.O.
2005: Rodney A. Hayward, M.D. & Mark S. Kaminski, M.D.
2004: John DeLancey, M.D.
2003: Gary L. Freed, M.D., Ph.D.
2002: Fred Morady, M.D.
2001: Sewon Kang, M.D. & Gary Fischer, Ph.D.


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Is 83.1 the Magic Number for the Market?
Trump Video Too Controversial for CNN, ABC and MSNBC? (Watch it here)
CNN, ABC and MSNBC refuse to show this video.
Once you watch it (click here), it's easy to understand why.
It totally goes against the mainstream narrative that Trump's presidency is a disaster.
In fact, this video proves Trump is about to make a lot of people rich.
Click here to watch the video the mainstream media won't show.
Still worried that this bull market doesn't have legs? Perhaps the latest data out of Thomson Reuters and the University of Michigan will put you at ease.
The institutions found that consumer sentiment has now reached 83.1 – the highest level in five years.
This essentially means that consumers feel stronger about the economy and are more likely to increase spending over the coming weeks and months.
Combine the uptick in sentiment with other bullish indicators – like a lower unemployment rate, falling jobless claims and mounting evidence of a sustainable housing recovery – and things could certainly look a whole lot worse.


text: NinongBrown Interact My Recent Posts Registered Member Posts: 5,356 #41 [url] Jan 18 08 1:59 PM man, you guys are hurting my feelings! sick watches! i have a few, but these two are what i've been wearing the most lately nothing crazy |THE|KLIQ|| PSN: ninongbrown | | Gorilla on dragon, Pat Morita, what does it all mean? ALL I'M SAYING IS THAT I WENT TO COLLEGE!!! | Quote Reply Remove this ad jumpman1212.niketalk Interact My Recent Posts Registered Member Posts: 1,433 #42 [url] Jan 18 08 2:34 PM A couple of my timepieces.... I'd call the Omega my daily beater... <--------"Why Those Guys Try To Hurt Me ??" Quote Reply lugasch Interact My Recent Posts Registered User Posts: 119 #43 [url] Jan 18 08 2:57 PM Omega Speedmaster Pro: Quote Reply MaZA4eVeR14 Interact My Recent Posts Registered Member Posts: 12,598 #44 [url] Jan 18 08 3:02 PM Some cheap rolex submariner lookin/knockoff invicta TeamAmericanMuscle EatingRiceDaily Eff Gas FS/FT: DS Nike Air Force 1 - Black Slam Jam Sz 14 - $140.00 shipped! Quote Reply Mr J Himself 23 Interact My Recent Posts Registered Member Posts: 1,654 #45 [url] Jan 18 08 4:25 PM Wifey copped me this for christmas *Collection FOR SALE* DS OG XIII,II,V,X,XX(stealth),XXI,XXII..DS DMP..Jordan dunks All Sz 11 For Sale!!! Come On Down, You're the next contestant on Buy Mr J's Sneakers!!! *Collection FOR SALE* DS OG Last Shot XIV Sz 11.5 and VVVNDS 2001 Black/Red I Sz 12 Quote Reply HOVKid Interact My Recent Posts Registered Member Posts: 5,772 #46 [url] Jan 18 08 4:43 PM I only have one watch: "Gentry Is The OG Killer" - 3thaman PSN - HOVKid Quote Reply DA6 Interact My Recent Posts Registered Member Posts: 989 #47 [url] Jan 18 08 4:46 PM This is one of my two SA watches. VIKINGSLAKERSDODGERS Quote Reply Nevik21 Interact My Recent Posts Registered User Posts: 139 #48 [url] Jan 18 08 4:58 PM Swiss Tag Heuer TEAM POKEMON ~ Machamp Quote Reply importfan9000 Interact My Recent Posts Registered User Posts: 162 #49 [url] Jan 18 08 5:04 PM This is my collection for now Benny&Co Ice Dial 2.6 Jacob&Co JC-2 Breitling SS Super Avenger 3 ct bezel I'm thinking about getting two of these: Cartier Roadster ss chrono xl Breitling Chronomat Evolution SS and Gold Breitling Bentley Motors 6.75 Black Dial Audemars Piguet Royal Oak Offshore Rubberclad White Dial Jaeger LeCoultre Master Compressor Extreme World Chronograph L O U I S V U I T T O N Breitling 1884 Instruments for Professionals Quote Reply hollowpoints Interact My Recent Posts Registered Member Posts: 3,364 #50 [url] Jan 18 08 5:13 PM TEAM-AF-ONE Quote Reply Remove this ad d3772000 Interact My Recent Posts Registered Member Posts: 1,547 #51 [url] Jan 18 08 5:17 PM Heres my daily... really its the only one i own that works..lol My wife kopped it for me for Christmas a couple years ago. Bulova Team Chad iyaf... Last Edited By: d3772000 Jan 18 08 5:20 PM. Edited 1 time. Quote Reply KICKINHEADZ1010 Interact My Recent Posts Registered Member Posts: 1,901 #52 [url] Jan 18 08 5:20 PM The sun Quote Reply nYcHipHopHippo Interact My Recent Posts Registered Member Posts: 6,968 #53 [url] Jan 18 08 5:49 PM Some of you have some crazy watches. All 3 are Movado. Edit: Check my feet all the way on the bottom T E A M N E W Y O R K K N I C K S WTB: Jordan XXI and Zoom BB II only DS sz. 9.5s Quote Reply CWK Interact My Recent Posts Registered Member Posts: 1,209 #54 [url] Jan 18 08 6:15 PM TUDOR PRINCE DAY DATE by ROLEX This was my wedding/college graduation gift to myself. Communism is the shortest distance betwen capitalism and capitalism. Quote Reply kevL7 Interact My Recent Posts Registered Member Posts: 1,061 #55 [url] Jan 18 08 6:18 PM RunsHouse23 wrote: Team Pacific Northwest PSN: kdublam Tumblr Quote Reply mikeynice Interact My Recent Posts Registered Member Posts: 1,029 #56 [url] Jan 18 08 6:21 PM . I love my Tag! Need to get a dressier watch next. "**** DEF JAM" Quote Reply nycsemaj Interact My Recent Posts Registered Member Posts: 910 #57 [url] Jan 18 08 6:27 PM Nice stuff everybody...looking to get a watch myself. Quote Reply CWrite78 Interact My Recent Posts Registered Member Posts: 17,908 #58 [url] Jan 18 08 6:42 PM RFX45 wrote: I only have designer watches at the moment, mostly for daily wear. I think it's time to move on though and I'm trying to work into getting a Tag and/or IWC though. I'll have to see if I can get good deals on those. How much for the Chanel? Quote Reply jblackcat13 Interact My Recent Posts Registered Member Posts: 12,824 #59 [url] Jan 18 08 6:45 PM Yeah I wanted to know how much the J12 cost. Either way it's probably gonna be way over what I can afford. I'm sorry...I'm so sorry Quote Reply yamakazi18 Interact My Recent Posts Registered Member Posts: 13,590 #60 [url] Jan 18 08 6:46 PM RFX45 wrote: yamakazi18 wrote: ahh, yes, the caliber 5000/pellaton on the portuguese is one of my favorites. i've been eyeing the perpetual calendar myself, too bad it's basically eyecandy for me until i get out of school. i've seen people selling the portugese for ~$5000-$6000 near mint condition on a few watch forums, you may want to check those out if you wish to save a grand or two for basically a new watch! have you also looked into other brands in the same price range? you can get some really beautiful nardins or audemars at that price range (gently used, or course), i tend to favor the artistry of those over the more conservative iwc's...if i want conservative it'll be a patek for a dress watch and mid-range for everything else. I've checked some forums selling the watch but if I can get the dealer to sell it for near the around the same price range, although it's going to be difficult, I would rather buy it from them and establish a relationship for the future. I've checked out Audemars but their Millenary series is a bit too plain for me and their Royal Oak series just isn't doign it for me. To be honest for the price of Audemars, I rather get a Hublot Big Bang. At least with those I don't have to worry about getting it banged up. I have this thing about black watches and I can't resist the Hublot's all black BB and ICE. I'm also considering Zenith, for some reason I just really like the complicated faces their watches have, their skeleton watches are nice too and it's pretty easy to get Zenith on a discount. come on man! audemars has some of the most intricate movements i've seen! have you checked out the jules line? i'm more of a movementhead than an intricate dialhead sort of guy so check this out: audemars time equation, my version of watch pr0n: and audemar's Grande et Petite Sonnerie Repetition Minutes Carillon, Reserve de Sonnerie et Dynamographe, just blows my mind with a THREE gong chime big bang's a nice choice, but from what i've seen/heard of it, it's quite large and not really for dressier occasions or even with a suit. it'll definitely make a great casual wear watch, but if you can afford a big bang for a casual watch you'll probably be able to afford all the audemars you want! i haven't seen/heard much from zenith (pronounced zeh-nEETh), other than their vintage watches, which look similar to vintage longines and are equally nice. Team Pacific Northwest Quote Reply Remove this ad Prev 1 2 34 5 …186 187 Next Forum Jump Forum FAQ New Members Sneaker Showcase News & Updates Nike Talk Nike Retro Jordan Brand Talk Reebok Asics Talk Puma Talk Adidas Talk Converse Talk Vans Talk New Balance Talk Fila Talk More Brands Sneaker Design & Conceptual Art Sneaker Restoration & Maintenance Sneaker Custom Modifications Sneaker Reviews Regional Forums Northeast MD/DC/VA Southwest SoCal NorCal Pacific Northwest Midwest Southeast Canada Philippines UK & Europe Rest of the World For Sale For Sale: Sizes 9 & Under For Sale: Sizes 9.5 to 10 For Sale: Clothing, Accessories, Everything Else For Sale: Women's Shoes For Sale: Sizes 11.5 & Above For Sale: Sizes 10.5 to 11 Wanted to Buy: Sneakers, Clothing, Everything Else Deals & Coupon Codes Brick & Mortar Stores Jordan Brand Price & Fake Checks Member Feedback & Agreements General Music Sports & Training Tech Clothing & Accessories Add Reply Quick Reply bbcode help Use Smilies (Complete smilies list) Convert URLs Subscribe to this topic Preview Quick Reply


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There are total 8 letters in Jealousy, Starting with J and ending with Y.
Total 105 words created by multiple letters combination of Jealousy in English Dictionary.
Jealousy is a scrabble word? Yes (18 Points)
Jealousy has worth 18 Scrabble points. Each letter point as below.
Words that starting with Jealousy
Words that containing Jealousy
Words that ending with Jealousy
Definition of the word Jealousy, Meaning of Jealousy word :
n. - The quality of being jealous, earnest concern or solicitude, painful apprehension of rivalship in cases nearly affecting one's happiness, painful suspicion of the faithfulness of husband, wife, or lover.


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A new law was passed by the Massachusetts Legislature on February 9, 2010, providing more options for persons that are being harassed to obtain a restraining order. The new law, Chapter 258E of the General Laws, provides the ability for the Superior Courts, Boston Municipal Court, District Courts, and Juvenile Court to issue Harassment Prevention Orders. (more…)
Archive for the 'Family Law' Category
New MGL c. 258E: Harassment Prevention Orders offers protection to victims of abuse, stalking, and harassmentSaturday, February 13th, 2010
I have been served. What shall I do?Saturday, August 8th, 2009
If you have been served with legal process by a constable, sheriff, or other person in Massachusetts most importantly do not ignore it. The papers you were served with should clearly indicate what you are expected to do. Even if you do not agree with what the papers say or how they were delivered some action is required. (more…)
Can I represent myself in court? Should I?Saturday, August 8th, 2009
In Massachusetts if you are an individual you have the right to represent yourself. This right is guaranteed in Article 12 of the Massachusetts Constitution. There are even many resources to assist you represent yourself. If you are not an individual, namely a corporation, LLC, trust, or some other entity, you need to retain an attorney. However, just because you have the right to represent himself should you? (more…)


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DEMOCRAT & CHRONICLE / SEARCH: 2128 Stout Road Willing, NY 14895
Single Family Residential
- 2 beds
- 1 baths
- $49,900 price
- R286148 mls id
- Year Built: 1900
- Status: A-Active
Country home in a beautiful setting. Located in the Town of Willing you will find this one family home located on .85 acres with berry bushes. Enter this home from the front porch into the foyer. The main floor includes a living room, dining room, kitchen, full bath and laundry room with a door leading to the side yard. Upstairs you will find two bedrooms, an office and a sewing room. The full basement has a concrete floor. The detached two car garage also has an attached workshop. Other buildings include a two story small barn and a storage building.
- Style 2 Story
Listing Agent: Victoria A Joyce Middaugh
Courtesy of: Middaugh Real Estate, Inc.
Office Phone: 585-593-3457
Updated: 20th August, 2017 11:51 AM.
2128 Stout Road Willing, NY
Real Estate | Democrat & Chronicle Powered by Placester


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Andruw to Rakuten
Rumour has it — rumour with an authoritative "u," no less — that Andruw Rudolf Jones will be taking his talents, and his unwieldy collection of Gold Gloves, to Japan. More specifically, what rumour has is that he'll be taking his talents to lovely, bustling Sendai, City of Trees, and of beef tongue, where the Tohoku Rakuten Golden Eagles of the Japanese Pacific League make their home. While fans of Todd "Moose" Linden, Darrell "Showstopper" Rasner, and Byung-Hyun "Mr. Not-tober" Kim will no doubt be intimately familiar with the Eagles, others of you may appreciate the opportunity to learn more.
Called simply "Rakuten" after their corporate sponsor, one of the largest e-commerce businesses in the world, the Eagles first suited up in 2005. Though they've only broken .500 twice, their pride is undimmed, as demonstrated by their four official cheer songs:
…and their two mascots, Clutch and Clutchyna:
The Eagles will surely welcome Jones' bat, as their 52 dingers this season ranked dead last in all of NPB. Curiously, there seems to be no announcement on their official website just yet. Judging from the warm welcome bestowed upon the seven young gentlemen above, however, Druw can look forward to an exceptionally friendly atmosphere. Here are some excerpts from their introductory press conference (tip of the cap to Google Translate):
Was carried out "press conference announcing the new players joined" at a hotel in Sendai on Thursday, December 13. While still in wear a nervous in front of the camera and press a bunch of line of sight of about 200 fan club members is poured, seven rookie players, showing off that magnificent comeback. I have taken the first step into the world of professional baseball. 7 to rookie players who joined to the Tohoku Rakuten Golden Eagles, thank you cheering warm hot.
…President Yozo Tachibana: Today, our fans, our media representative, Thank you for taking the time. Looking back on this season, I was unfortunately result in # 4. However, the coming season mainly Hoshino, I have already started off. Also, I would be today, excellent player who joined Seven. Have a lot of practice firmly in the future, we are in the hope that it will be a pillar of players like Rakuten Eagles. In addition, seven players, including this, thank you fans next season, with hot cheer if the Rakuten Eagles.
…Reporter: How do you want to heat up and Hoshino, Hoshino impression?
Mori: I have an image that is very strict person, there is a further image of incredibly hot. I think leading his team to victory in the spirit of his pitching in, and I should let a hot director.
?: I think that those who very dashing. I think leading his team to victory in the pitching in spirit, and you want to hot Hoshino too.
Otsuka: I think those who are very presence. I think I'll leave the scene, which is hot and you want to be kept securely.
Shimotsuma: I think I think you're hot and very strict supervision, because their larger body, and I get hot in the play such a large scale.
Shimai: I think that I am very hot. I think we would like to hot to play the best.
Kakizawa: I think the director has thrown the entire surface of the soul, I think I want to sprint like best-play not to lose it.
Miyagawa: I think that I am hot. But I would like to pitching overflowing spirit, and want to hot.
…Reporter: What you come to the Northeast, where I want to say, and what I want to eat, is that you have to look forward to other than baseball?
?: I think Sendai beef tongue is very famous since it with, I think I want to eat a lot, four high school students so they sync, and want to go off somewhere together on the day of the Forest.
?: I think though I will be the same as the players forest, and that beef tongue is very famous, and I want to eat a full stomach beef tongue.
Otsuka: I think I also want to eat beef tongue.
Shimotsuma: I also want to eat a cup of beef tongue. After that, but I went on a school trip to Matsushima in the days of elementary school before, I'd like to go again Matsushima landscape was so beautiful.
Shimai: I want to learn it's Date Masamune.
Kakizawa: I think I also want to eat beef tongue. I think I want to walk with you and the rest of the day off Otsuka.
Miyagawa: I want to eat a full stomach I also beef tongue.
Needless to say, I'll be keeping close tabs on the site, and will pass along a full account of Mr. Jones' introduction, as well as his feelings on hotness and beef tongue, as soon as they are published.
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