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3 bedroom semi-detached house for saleThe Square, Grampound Road, Truro, Cornwall
Sold STC £235,000
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Call: 01872 810810
Property Description
Full description
Tenure: Freehold
A well planned and attractively designed three bedroomed semi-detached house with a large conservatory to the rear. With slate hanging and stone work to the exterior, the property is to be sold with no ongoing chain and offers a deceptive appearance from the roadside as to the accommodation on offer. Within a cul-de-sac of similarly designed properties, the house is found within the heart of the village and has a gas central heating system and double glazing.
Further points to note include laminate flooring within the entrance hallway and conservatory and utility room and, via the entrance hallway, there is a cloakroom, a lounge/dining room with a gas coal effect fire and double glazed French doors to the conservatory, the kitchen/breakfast room which is equipped with a hob, oven and hood and adjoining is a the utility room and an integral garage.
At first floor level, two of the bedrooms have fitted wardrobes and the master bedroom has an en-suite bathroom. In addition, there is a family bathroom with a shower over the bath.
The gardens have been designed for ease of maintenance and to the front exterior, there is a good sized brick paved driveway.
Grampound Road has a local shop/post office and a primary school. In addition, there is a cricket ground, which has a new pavilion and this is used for additional village facilities. A bus service serves both Truro and them market town of St Austell. The village itself is also handily placed for the north coast and Newquay.
Property ref: 121_1890_4240120
The Accommodation Comprises
Canopied entrance porch with side pillars and outside courtesy light, paved flooring and entrance door to entrance hallway.
Entrance Hallway
Laminate flooring, double radiator, coving, staircase to first floor.
With a wash hand basin, hot and cold, with tiled splashback, low flush WC, under stairs storage cupboard, extractor fan, two ceiling downlights, fuse box, radiator.
Lounge/Dining Room
17' 7" x 10' 10" (5.35m x 3.31m) excluding bay window. Bay window, two double radiators, gas coal effect fire with marble hearth and surround and timber mantle. Coving, television point, telephone point, front and rear garden views, double glazed French doors to conservatory.
12' 8" x 11' 3" (3.85m x 3.42m) plus 10' 10" x 5' 3" (3.29m x 1.60m) Partially tiled and laminate flooring, two double radiators, rear aspect views, double glazed French doors to rear garden, ceiling spotlights, two wall lights. Half glazed, double glazed door to kitchen/breakfast room.
Kitchen/Breakfast Room
11' 6" x 10' 4" (3.50m x 3.16m) wall to wall. Tiled flooring, additional door to entrance hallway, stainless steel sink unit, hot and cold, with centre sink tidy and side drainer with cupboards below. Further range of working surfaces with cupboards and drawers under. Tiled splashback, wall mounted units with concealed lighting. Five ring gas hob with extractor hood over, double, seven ceiling downlights, coving, telephone point, television point.
Utility Room
8' 5" x 5' 3" (2.57m x 1.59m) wall to wall. Stainless steel sink unit, hot and cold, with side drainer with cupboard and space below. Laminate flooring, space for washing machine and tumble dryer. Wall mounted cupboards and shelving, Vokera central heating boiler, tiled splashback, loft space. Door to integral garage.
First Floor
Landing, staircase from entrance hallway, loft space with ladder to boarded and carpeted loft, radiator.
Comprising of a panelled bath, hot and cold, with a shower with glass screen. Fully tiled walls, radiator/towel rail, low flush WC, wash hand basin, hot and cold, with cupboards below, wall mounted mirror, fluorescent light/electric shaver socket point, four ceiling downlights, extractor fan.
Bedroom One
11' 5" x 10' 1" (3.47m x 3.07m) into wardrobes. Two sets of fitted wardrobes, rear aspect views, coving, telephone point, television point, two bed lights, one ceiling downlight.
En-Suite Bathroom
With a low flush WC, radiator/towel rail, wash hand basin, hot and cold, with cupboards below, extractor fan. Partial coving, partial tiled surround, five ceiling downlights, eaves cupboards. Panelled bath, hot and cold, with shower with glass screen and tiled surround, side wall light.
Bedroom Two
10' 8" x 10' 2" (3.26m x 3.11m) into wardrobes. Fitted wardrobes, double radiator, rear aspect views, coving, television point, telephone point.
Bedroom Three
10' 1" x 6' 11" (3.07m x 2.10m) Front aspect views, coving, radiator, television point, telephone point.
Integral Garage
12' 6" x 8' 3" (3.82m x 2.52m) Gas meter, fuse box, lighting and power, up and over door, rear personal door to utility room.
Front Garden
The front garden has a brick paved driveway providing parking for a number of vehicles. To the side, there is a gravelled border for ease of maintenance.
Rear Garden
This is approached via a side wrought iron gate with a brick paved pathway leading to a maintenance saving garden which has a curved, brick paved sun terrace/patio and this flanks a gravelled area. The garden is enclosed by walling and fencing. Attached to the house, there is an outside courtesy light.
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Listing History
Nearest station
- St. Columb Road (5.6 mi)
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Disclaimer - Property reference 4240120. The information displayed about this property comprises a property advertisement. Rightmove.co.uk makes no warranty as to the accuracy or completeness of the advertisement or any linked or associated information, and Rightmove has no control over the content. This property advertisement does not constitute property particulars. The information is provided and maintained by Simon Milnes, Truro. Please contact the selling agent or developer directly to obtain any information which may be available under the terms of The Energy Performance of Buildings (Certificates and Inspections) (England and Wales) Regulations 2007 or the Home Report if in relation to a residential property in Scotland.
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LAOS – Mekong Discovery
(Day 276 to 278)
24.08.2010 - 26.08.2010
View Round The World Map on kostlin's travel map.
Border Crossing
From Chiang Rai, we hopped onto a small local bus that would take us to the border town of Chiang Khong in two hours for the small fee of 65 Baht each. Once we got there we took a quick Tuk Tuk to the Thai border crossing, followed by a boat that would take us across the river and see us standing proudly on Lao soil.
After paying for our visa (U$30) and buying our Slowboat ticket, we found our way to our guesthouse which was conveniently situated on the river, right by the Slowboat Pier for the next morning's trip. Getting to the boat early in the morning is vital to secure a good seat near the front, so this guesthouse was ideal for us.
Journey down the Mekong
This would be a 2 day journey to Luang Phabang, fitted with bum-numbing wooden benches most probably used in torture chambers during the war! After the fist day on the boat, we'd reached Pakbeng, a ramshackle old town on the banks which seems to cater mainly for the tourists stopping over. This is unavoidable as boats don't operate at night. We were expecting cold water and sporadic electricity, and braced ourselves for a bad night but although the accommodation was basic, the stop was perfectly fine (with elect and hot water!).
The boat trip was pleasant and the scenery pretty and peaceful, with small villages along the way and the greenest fields & hills we've seen so far which were shrouded with low lying clouds. This is the advantage of travelling during the rainy season but it does mean a daily dose of rain, which we have had without fail so far. Although enjoyable, this trip was very touristy and mainly because of this, would never compare to the amazing slowboat trip we had done over 3 days up the Amazon just a few months ago. Nevertheless, we discovered the Mekong River and that was special in itself.
The Mekong is the 7th longest river in Asia, starting in the Tibetan Plateau, the river runs through China, Burma, Laos, Thailand, Cambodia and Vietnam.
After another 8hr day on the boat on Day 2, we finally arrived in the laidback town of Luang Phabang. This time our boat had been upgraded to a 'Tourist Boat' with comfy seats and a western toilet

subset: commoncrawl


text:
University courses are designated by UNIV.
The University Experience
helps students develop the skills and strategies that will benefit them as they make the transition from high school to university. Class activities and assignments focus on critical and creative thinking, communication skills, self-awareness, information literacy, and the ability to work in teams. Students will explore the campus community and examine the role the university plays in our society.
Critical Reading and Writing: A Path to Future Studies
broadens students' understanding of the multi-disciplinary nature of the university. Concentrating on reading and writing activities in multiple media, students will see how dialogue and text are involved in defining, creating, supporting, debating, refining, and disseminating research-based knowledge. The course offers students an opportunity to improve their own skills in an active and collaborative learning environment. All sections of this course follow Critical Reading and Writing Course Guidelines available at www.mun.ca/hss/crw.
CR: the former UNIV 2020
Introduction to Critical Reading and Writing in University
(same as the former Arts 1500) introduces students to some of the processes, techniques and standards of university-level critical reading and writing. Students will engage in the practices of critical reading and pre-writing, drafting, revising and editing texts. An emphasis will be placed on using writing in response to critical reading exercises. All sections of this course follow Critical Reading and Writing Course Guidelines available at www.mun.ca/hss/crw.
CR: the former Arts 1500
PR: restricted to students with fewer than eighteen credit hours
International Study Program
is a non-credit hour designation that signifies completion of a Harlow Campus semester, a field school offered outside of Canada by Memorial University of Newfoundland, or completion of another program of study requiring residency outside of Canada. The normal period of residency outside of Canada is 12 weeks.
CO: enrollment in approved courses requiring residency outside of Canada (normally a minimum of 9 credit hours)
PR: acceptance into an approved university level study program located outside of Canada
International Internship
is a full-time work or voluntary experience for at least 12 weeks duration in a location outside of Canada. Students are expected to learn, develop and practice the high stand of behaviours and performance normally expected in the work environment. Students should have sufficient academic grounding in international concepts to contribute to the international workplace, to acquire intercultural competencies and to develop as global citizens.
CR: any work term course with the final character of "w"
PR: enrollment in the iBA; minimum third-year standing with a minimum 70% average; minimum 6 credit hours in Language Study (LS) courses; and 12 credit hours in designated International Studies (IS) courses.


text:
Southeast Centers,LLC & SEC Commercial Realty offer a fully integrated platform of best-in- class services, buttressed by long established operating philosophies and high-level, dedicated talent.
Strategic Property/Asset Management
Our comprehensive approach to accretive property management and asset enhancement demands that we anticipate, innovate, collaborate, and communicate with our clients. We execute thanks to an impressive team of experienced Property Managers who seek to exceed all internal and external performance expectations. Over the past 30 years, our portfolio has reached over 4 million square feet, and we have distinguished ourselves as the most conscientious and effective property managers in Florida
Proactive Leasing
Our Leasing Professionals leverage deep experience, meaningful relationships, and diligent strategy execution to ensure optimum occupancies and reliable revenue streams. We stay focused on our clients' desired investment returns, and measure our success by the level to which we have exceeded those expectations.
Acquisition & Development
Southeast Centers, LLC is actively looking to acquire shopping centers, commercial properties and vacant land throughout Florida and the southeast United States. The management of Southeast Centers has extensive experience in evaluating and acquiring quality commercial property, having successfully built or purchased over 50 shopping centers.
Professional Design and Construction Management
Our construction and design department has the experience and expertise to handle new construction, re-developments and renovations of commercial properties throughout Florida. We have designed and built commercial properties for Publix, Winn Dixie, Walgreens, CVS (Eckerd), TJ Maxx, HomeGoods, Havertys Furniture, Ross Dress For Less, Starbucks, OfficeMax, Barnes&Noble, Goodyear Tire and hundreds of other notables companies. "Let us build your next shopping center in Florida!"


text:
Ok, it's not really a throwdown – everyone's a winner when it comes to delicious Mexican sandwiches. Since moving to Sunset Park, I've been ravenously sampling the neighborhood's torta offerings. A torta is a beast of a sandwich – a round white roll piled with (usually) one or more meats, white cheese, refried beans, lettuce, […]
Required Reading
Recent Comments
- Drug Test on Season of Liquid Sandwiches: Blue Bunny
- hugo boss perfumes on Scare Away E. Coli with Mini-Burgers at L'Orange Bleu
- kill la kill on Grandaisy Bakery – It's All About the Bread
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- wake up now on Change We Can Believe In: Artisanal's Grilled Cheese Bar
'Wich List- Press 195
- Kelly's Roast Beef
- Bahn Mi Saigon Bakery
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- Kensington Kosher Deli
- Grape and Grain
- Aamachi Pao
- Saltie


text:
They are a great Mexican establishment that we frequent weekly and almost always have good service and great food!
1 - 10 of 45 reviews
They are a great Mexican establishment that we frequent weekly and almost always have good service and great food!
Ordered my go to chicken enchiladas with green sauce. The sauce was very odd. Beans were good. All in all food was just okay. Salsa was like tomato sauce. Service was excellent: quick, attentive and very friendly.
We dine here occasionally since we live in town. The service and atmosphere are always great, and we enjoy going there. The menu is very large and had your typical Mexican foods. The portions always seem to be more than enough, so we usually have...More
I've been here serval times but I always seem to be a creature of habit and order the same entrée so I can't rowing to have too much of an opinion on any of the other menu items. However, I will say that this restaurant...More
We have a large family and don't eat out often, but this is probably where we splurge most often. The food is always fresh, hot, and fast. The salsa and chips are the best around, and the waiters are forever charming.
My wife and I stopped here on our way through Tell City and didn't regret it. We are always impressed when service by a particular restaurant is very good and The Fiesta Grande did not disappoint. Food was very good, wait time was short, price...More
We went there for lunch and the menu is the same old, same old, just like any other mexican restaurant. The waiter was ok... pure business. Overall, it is an average restaurant.
If you want real authentic Mexican food this is the place to come to. Excellent food, great service. It's my favorite.
Nothing Authentic about this place. Good service. Horrible parking if you come during the dinner hours. But the reason this is a 3 for me and my husband, the watered down the Margaritas. The Margarita were $7 dollars each. I would go again at a...More
Prices are at a normal range for all items on menu. Food was in large portions and you do not leave hungry. Very tasty food.


text:
Karen Carrot is a common Bakery and Family Food Shopkin from Season Six. She is included in the Carrot Cake recipe in the Bakery team and the Fried Rice recipe in the Family Food team.
Karen Carrot: Loves to dig in and help with the cooking. Some of her friends think she looks more orange than an orange! But she doesn't carrot all.
Karen Carrot is a carrot with an orange to red ombré effect and a green stem.
There are no variants of her.
- Although she is included in the Family Food team as well as the Bakery team, the collector's tool only lists her as being in the Bakery team.
- She is the second carrot Shopkin, the first being Wild Carrot from Season Three.


text:
Journal of Nature and Science (JNSCI), Vol.3, No.5, e358, 2017
T cells targeting neuromyelitis optica autoantigen aquaporin-4 cause paralysis and visual system injury
Andr��s Cruz-Herranz1, Sharon A. Sagan1,2, Raymond A. Sobel3, Ari J. Green1, and Scott S. Zamvil1,2,*
1 Department of Neurology and 2 Program in Immunology, University of California, San Francisco, CA 94143, USA. 3 Department of Pathology, Stanford University, Stanford, CA 94305, USA
Aquaporin-4 (AQP4)-specific antibodies are instrumental in promoting central nervous system (CNS) tissue injury in neuromyelitis optica (NMO), yet evidence indicates that AQP4-specific T cells also have a pivotal role in NMO pathogenesis. Although considerable effort has been devoted to creation of animal models to study how AQP4-specific T cells and antibodies may cooperate in development of both clinical and histologic opticospinal inflammatory disease, the initial attempts were unsuccessful. Recently, it was discovered that T cells from AQP4-deficient (AQP4-/-) mice recognize distinct AQP4 epitopes that were not identified previously in wild-type (WT) mice, and that donor Th17 cells from AQP4-/- mice that target those novel epitopes could cause paralysis and visual system injury associated with opticospinal inflammation in WT recipient mice. These observations indicate that the pathogenic AQP4-specific T cell repertoire is normally controlled by negative selection. Here, we describe the advances leading to development of an animal model for aquaporin-targeted CNS autoimmunity (ATCA). This new model provides a foundation to investigate immune mechanisms that may participate in NMO pathogenesis. It should also permit preclinical testing of agents considered for treatment of NMO.
neuromyelitis optica | aquaporin-4 | T cells | experimental neuromyelitis optica | experimental autoimmune encephalomyelitis
Neuromyelitis optica (NMO) is a CNS autoimmune inflammatory demyelinating disease that can cause severe, disabling paralysis and visual loss [1]. Unlike multiple sclerosis (MS), a more common CNS inflammatory disease that is considered to primarily target myelin proteins produced by oligodendrocytes, the target in NMO is aquaporin-4 (AQP4), a water channel expressed abundantly on astrocyte end-foot membranes in areas contacting the blood-brain barrier [2]. Pathogenic antibodies to AQP4 are found in the serum of approximately 75% of NMO patients [3]. NMO is therefore considered a humoral autoimmune disease. However, there is increasing evidence linking T cells to the pathophysiology of NMO. AQP4-specific antibodies are IgG1, a T-cell dependent Ig subclass [4] and their entry to the CNS requires inflammation [5, 6]. NMO patients have a higher frequency of AQP4-reactive T cells than healthy controls, and those T cells produce IL-17, providing evidence for a role of Th17 cells in NMO pathogenesis [7]. Yet, the precise contribution of T cells to opticospinal inflammation and neuronal damage in NMO has not been clarified. Animal models, which may elucidate how AQP4-specific T cells and antibodies cooperate in CNS autoimmunity are sorely needed.
Although multiple AQP4 T cell epitopes have been identified in WT mice and rats [8-10], development of a model with clinical and histologic manifestations of opticospinal autoimmune disease that targets AQP4 has proven challenging. Immunization with those identified peptide determinants or transfer of donor T cells targeting those epitopes did not induce clinically evident AQP4-targeted experimental NMO (��ENMO��) [9-11]. Zeka et al. did detect inner retinal T cell infiltration with permanent retinal ganglion cell (RGC) injury in Lewis rats after transfer of AQP4 p268-285-specific T cells, with or without injection of NMO-IgG, but did not observe significant paralysis [12].
In recent work, Sagan et al. studied AQP4-specific T cell responses in both AQP4-deficient (AQP4-/-) and WT mice [13]. Robust proliferation was observed following immunization of AQP4−/− mice with AQP4 peptide (p) 135�C153 or p201�C220, the two AQP4 peptides predicted to bind MHC II (I-Ab) with highest affinity. In contrast, these two AQP4 peptides elicited much weaker T cell responses in WT mice. The T cell receptor (TCR) repertoires used for recognition of AQP4 p135-153 and p201-220 in AQP4-/- mice were also unique. Collectively, these findings indicate that development and expansion of AQP4-specific T cells is regulated by thymic negative selection. Donor AQP4 p135-153-specific or p201�C220-specific T cells from AQP4−/− mice caused acute paralysis that was accompanied by opticospinal inflammation in WT and B-cell�Cdeficient mice. In comparison to Th1 cells, Th17-polarized AQP4-specific cells caused more severe clinical and histologic disease than AQP4-specific Th1 cells, providing further support for a Th17-mediated etiology in AQP4-targeted CNS autoimmunity (ATCA). Fluorescent-labeled AQP4-specific T cells were identified in infiltrates within the spinal cord and optic nerves, demonstrating that those pathogenic T cells had indeed penetrated the CNS. Optical coherence tomography (OCT) was used to monitor changes in the thickness of the inner retinal layers and revealed dynamic changes after induction of disease. Interestingly, although AQP4 is expressed in other organs (e.g., kidney and muscle) [14], AQP4-targeted T cell-mediated inflammation was detected in the CNS only.
Whereas AQP4 is the principal autoantigen in NMO, myelin oligodendrocyte glycoprotein (MOG), which itself is highly expressed on the surface of the outer lamellae of CNS myelin in the optic nerves and spinal cord [15], is a candidate autoantigen in multiple sclerosis (MS) [16-18]. Of interest, a subset of AQP4-IgG seronegative patients that have been diagnosed with NMO produce anti-MOG IgG [19]. While AQP4- and MOG-specific antibodies target different cell components of the CNS, relapsing optic neuritis is frequent in both groups of patients [20]. In their report, Sagan et al. studied the differential features of MOG- and AQP4-targeted T cell-mediated CNS autoimmunity. They compared the disease course, retinal dynamics, histological and immunohistochemical findings in WT mice receiving either Th17-polarized AQP4 p201-220-specific or MOG p35-55-specific T cells. MOG-specific Th17 cells induced classic EAE, with persistent paralysis associated with axonal loss in the spinal cord as well as initial inner retinal swelling that led to atrophy and reduction of retinal ganglion cells (RGCs). In contrast, both paralysis and retinal swelling induced by AQP4-specific Th17 cells were self-limited and there was no loss of spinal cord axons or RGCs. These findings highlighted distinct roles for T cells targeting cell surface astrocyte- and oligodendrocyte-specific proteins in CNS autoimmunity, which should provide insight regarding their respective roles in NMO and MS.
It is recognized that AQP4-specific IgG1 can have a key role in the effector stage of NMO. In this regard, Felix et al. [21] found that intravitreal delivery of anti-AQP4 IgG reduced AQP4 expression and increased glial fibrillary acidic protein with retinal inflammation and loss of ganglion cells in the retinas of adult rats and, surprisingly, this primary retinal pathology was complement-independent. After Sagan et al. [13] first demonstrated that AQP4 contains two pathogenic T cell epitopes, p135-153 and p201-220, in mice, Vogel et al. [22] reported that T cell- and B cell-deficient (Rag1-/-) mice reconstituted with naive peripheral CD4+ T cells from AQP4-/- mice were susceptible to induction of CNS autoimmunity by immunization with AQP4 p201-220. They also identified an NMO lesion-like pattern only upon concomitant administration of anti-AQP4 antibodies.
It took more than five years from the discovery of AQP4-specific T cell epitopes in mice [8] before investigators first succeeded in creating a model of clinical and histologically evident ATCA [13, 22, 23]. This advance was made by the discovery that pathogenic AQP4 T cell epitopes are concealed by the normal immune system. T cells that recognize the unique pathogenic AQP4 T cell determinants, identified by studying AQP4-/- mice, utilize both unique T cell and TCR repertoires, findings that indicate AQP4-specific T cells are normally sensitive to mechanisms of central tolerance. In future investigations, it will be important to examine whether specific gene products known to control thymic negative selection shape the AQP4-specific T cell repertoire in ATCA. One can speculate that a defect(s) in thymic negative selection might also participate in NMO pathogenesis. It is clear that the identification of multiple pathogenic AQP4 T cell epitopes should accelerate research to understand how pathogenic AQP4-specific T cells develop in NMO and how they may direct differentiation of AQP4-specific B cells and antibody-secreting plasma cells.
A. C.-H. is a fellow of the National Multiple Sclerosis Society (NMSS) (FG-20102-A-1). This work was supported by grants to S.S.Z. from the National Institutes of Health (1 RO1 NS092835-01 and 1 RO1 NS0630008-01) and the NMSS (RG 5180A11/1) and to A.J.G. by the NMSS (RG-1701-26783).
1. Wingerchuk, D.M. et al. (2007) The spectrum of neuromyelitis optica. Lancet Neurol 6 (9), 805-15.
2. Hubbard, J.A. et al. (2015) Expression of the Astrocyte Water Channel Aquaporin-4 in the Mouse Brain. ASN Neuro 7 (5).
3. Waters, P.J. et al. (2012) Serologic diagnosis of NMO: a multicenter comparison of aquaporin-4-IgG assays. Neurology 78 (9), 665-71; discussion 669.
4. Nurieva, R.I. and Chung, Y. (2010) Understanding the development and function of T follicular helper cells. Cell Mol Immunol 7 (3), 190-7.
5. Bradl, M. et al. (2009) Neuromyelitis optica: pathogenicity of patient immunoglobulin in vivo. Ann Neurol 66 (5), 630-43.
6. Bennett, J.L. et al. (2009) Intrathecal pathogenic anti-aquaporin-4 antibodies in early neuromyelitis optica. Ann Neurol 66 (5), 617-29.
7. Varrin-Doyer, M. et al. (2012) Aquaporin 4-specific T cells in neuromyelitis optica exhibit a Th17 bias and recognize Clostridium ABC transporter. Ann Neurol 72 (1), 53-64.
8. Nelson, P.A. et al. (2010) Immunodominant T cell determinants of aquaporin-4, the autoantigen associated with neuromyelitis optica. PLoS One 5 (11), e15050.
9. Kalluri, S.R. et al. (2011) Functional characterization of aquaporin-4 specific T cells: towards a model for neuromyelitis optica. PLoS One 6 (1), e16083.
10. Pohl, M. et al. (2011) Pathogenic T cell responses against aquaporin 4. Acta Neuropathol 122 (1), 21-34.
11. Zeka, B. et al. (2015) Highly encephalitogenic aquaporin 4-specific T cells and NMO-IgG jointly orchestrate lesion location and tissue damage in the CNS. Acta Neuropathol 130 (6), 783-98.
12. Zeka, B. et al. (2016) Aquaporin 4-specific T cells and NMO-IgG cause primary retinal damage in experimental NMO/SD. Acta Neuropathol Commun 4 (1), 82.
13. Sagan, S.A. et al. (2016) Tolerance checkpoint bypass permits emergence of pathogenic T cells to neuromyelitis optica autoantigen aquaporin-4. Proc Natl Acad Sci U S A 113 (51), 14781-14786.
14. Mobasheri, A. et al. (2007) Distribution of the AQP4 water channel in normal human tissues: protein and tissue microarrays reveal expression in several new anatomical locations, including the prostate gland and seminal vesicles. Channels (Austin) 1 (1), 29-38.
15. Berger, T. et al. (1997) Experimental autoimmune encephalomyelitis: the antigen specificity of T lymphocytes determines the topography of lesions in the central and peripheral nervous system. Lab Invest 76 (3), 355-64.
16. Genain, C.P. et al. (1999) Identification of autoantibodies associated with myelin damage in multiple sclerosis. Nat Med 5 (2), 170-5.
17. Kerlero de Rosbo, N. et al. (1993) Reactivity to myelin antigens in multiple sclerosis. Peripheral blood lymphocytes respond predominantly to myelin oligodendrocyte glycoprotein. J Clin Invest 92 (6), 2602-8.
18. Varrin-Doyer, M. et al. (2014) MOG transmembrane and cytoplasmic domains contain highly stimulatory T-cell epitopes in MS. Neurol Neuroimmunol Neuroinflamm 1 (2), e20.
19. Zamvil, S.S. and Slavin, A.J. (2015) Does MOG Ig-positive AQP4-seronegative opticospinal inflammatory disease justify a diagnosis of NMO spectrum disorder? Neurol Neuroimmunol Neuroinflamm 2 (1), e62.
20. Hoftberger, R. et al. (2015) Antibodies to MOG and AQP4 in adults with neuromyelitis optica and suspected limited forms of the disease. Mult Scler 21 (7), 866-74.
21. Felix, C.M. et al. (2016) Complement-independent retinal pathology produced by intravitreal injection of neuromyelitis optica immunoglobulin G. J Neuroinflammation 13 (1), 275.
22. Vogel, A.L. et al. (2017) Deletional tolerance prevents AQP4 directed autoimmunity in mice. Eur J Immunol.
23. Jones, M.V. et al. (2015) Pathogenic aquaporin-4 reactive T cells are sufficient to induce mouse model of neuromyelitis optica. Acta Neuropathol Commun 3, 28.
Conflict of Interest: No conflicts declared.
* Corresponding Author: Scott S. Zamvil, M.D., PhD. Professor of Neurology and Faculty, Program in Immunology, University of California, San Francisco, 675 Nelson Rising Lane, NS-215A, San Francisco, CA 94158, USA.
Tel: 415-502-7395; Fax: 415-502-7241.
E-mail: firstname.lastname@example.com
© 2017 by the Authors | Journal of Nature and Science (JNSCI).


text:
For Urban Gateways, September 2015
Without Hazard Press Photos
These are press photos taken for St. Louis-based band Without Hazard. You can contact them at http://www.withouthazard.com/
Here is a poster featuring one of my photos. Note that I did not make this poster.
Without Hazard
Carl Kennedy Senior Recital
DePaul Jazz Combo: An Education
This is a photo slideshow of members of DePaul's jazz program, with interviews from a select number of students. This project was made for class in March 2013.


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List of five leading wicket takers of DPL
- Bangladesh, Countries, Division, Domestic, News, Recent, Slides, Top News 2
- June 23, 2016
Abahani Limited : 305/10 in 49.2 overs (Sadman 103, Liton 65, Saif Hasan 51, Alamin 3/47, Ariful 3/58, Salman 2/38) Prime Bank Cricket Club : 198/10 in 44.5 overs (Salman 61*, Mehedi Maruf 31, Al Amin 31, Shuvagata 5/47, Manan 2/41, Kazi Anik 1/25) Result- Abahani Limited won by 112 runs. Player of the matchREAD MORE
Victoria Sporting Club : 155/10 in 45.3 overs (Uttam Sarker 35, Rubel Mia 28, Moinul 21, Raza Ali 3/13, Mosharraf 2/36, Sharif 2/44) Legends of Rupganj : 156/4 in 45.3 overs (Pinak Ghosh 62, Naeem Islam 29*, Mosharraf 21, Arafat Sani-2 1/16, Rubel Mia 1/17, Imamul 1/31) Legends of Rupganj won by 6 wickets. PlayerREAD MORE
Prime Doleshwar SC : 228/9 in 50 overs (Abdul Majid 50, Forhad Reza 46, Jakir Ali 40, Asalanka 3/29, Sajedul 3/30, Taijul 1/44) Mohammedan SC : 232/4 in 47.4 overs (Avishek Mitra 95, Rakibul 49*, Nazmul Milon 26*, Imtiaz 1/7, Arafat Sunny 1/60) Result- Mohammedan Sporting Club won by 6 wickets. Player of the matchREAD MORE
Opening batsman Imtiaz Hossain's 99 runs innings helped his side Prime Doleshwar Sporting Club (DPSC) to secure a four-wicket win over Brothers Union at the Fatullah Cricket Stadium. Chasing a target of 247, Imtiaz and Abdul Mazid's 86-run opening stand gave their team a flying start. Although Mazid went back to the pavilion after scoringREAD MORE
Legends of Rupganj's Mushfiqur Rahim and Naeem Islam's individual hundreds set up their side's 68-run win over Sheikh Jamal Dhanmondi Club in the second round of Dhaka Premier Division Cricket League 2016-17 on Monday. In this match after winning the toss at Bangladesh Krira Shikkha Prothisthan Ground-4 in Savar, Mushfiqur's Rupganj lost their openers withinREAD MORE
Maiden List-A hundred for Nazmul Hossain Shanto led his side Abahani Limited to thrash Partex Sporting Club by seven wickets at Bangladesh Krira Shikkha Prothisthan Ground-3, Savar. The 20-year old young batsman played 109 balls during his match winning knock of 102 runs, hitting five fours and four sixes. Chasing a target of 235 runs,READ MORE


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"I think he's a great base runner," third base coach Bo Porter said. "He was thinking double right out of the box. A lot of times, guys come out of the box, and then they make up their mind when they're rounding first. Jayson made up his mind when he hit that ball that he was going to go for two. That's the most important thing. He was committed to a double the whole time."
Werth has not yet attempted to steal a base, and because Ryan Zimmerman is hitting behind him, Werth may curtail his stealing. But when he does try to steal, you can be quite certain he'll make it. Over the past three years, Werth has stolen 53 bases in 60 tries, the third best rate in the majors over that span.
The top two, Chase Utley and Jimmy Rollins, also played for the Phillies and, more significantly, studied under coach Davy Lopes, who has since moved to the Dodgers. Werth credits Lopes for his skill as a base runner, particularly his focus on stolen base percentage and going first to third on singles.
Last year Werth took an extra base – going first to third on a single, second to home on a single or first to home on a double – 47 percent of his chances. The 2010 National League average was 40 percent league, and the Nationals took an extra base on 36 percent of their opportunities.
"It's a big part of the game," Werth said. "I do take great pride in my base running. You look at stolen base percentage and going first and third. Making good choices out there, it's all a part of winning baseball."
The Nationals made taking an extra base a theme during spring training, and for three games they're off to a reasonably good start. They've had four chances to take an extra base, and they have done so four times. Werth has been responsible for two of those.
It also hasn't hurt that Werth was the Nationals' best hitter during their opening series, going 4 for 10 with two doubles and two walks.


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"Ceriakan Duniamu" bersama Suria FM
Content rating: Everyone
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The President's message to the people of Kazakhstan
Our development programs of education, health care and agriculture will continue. We will have substantive discussion of these programs at the first enlarged session of Government the next year.
X-ray surgery department
Based at the X-ray Surgical Department of the City Cardiological Center there are master classes that are performed on a permanent basis there with the participation of intervention cardiologists from Austria, Czech Republic, Poland, Serbia, Slovenia and Lithuania.
Best medical institution
A joint project of the National socio-political newspaper «President and people» with the Republican Agency «Уақыт Таңдауы – Selection of time » has identified favor
Cardiosurgical department
Since 2008 in the City Cardiological Center there is a Cardiosurgical Department functioning where patients receive specialized high tech help. As of today, the Department of Cardiosurgery is the only clinic in Almaty that provides emergency cardiological help.


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"I love you" means that I accept you for the person that you are
I'm so lucky to be in love, to have someone to grow old with and blessed that it's you xx
Hainanese Chicken Rice - "The F Word" Tribute
Sio Bak 烧肉 (Roast Pork Belly)
Homemade Yeast from an Apple
Making your own yeast - need homegrown grapes or or other wild fruit or water from boiled potatoes to make. Perhaps start this in the spring when I can find some wild fruits.
Wake up to a delicious protein boost with this yogurt-based smoothie that's loaded with kale, strawberries, bananas and apples.
This healthier double chocolate banana cake is incredibly moist without any oil or butter.
French Hot Chocolate- an easy, dark hot chocolate that tastes just like the kind served in Paris cafes!
No Washing Up Ham Egg & Cheese Bread Bowls


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Generally traditions help toward spiritual progress, but sometimes a tradition becomes a goal in itself with no meaning and can hider your progress. I won't list traditions I consider to be hindrances for fear of pissing off a lot of people. Enough to say that if a tradition loses its meaning for you, consider abandoning it.
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I like your answer and understand about pissing people off. It was something that I faced in writing my hub-to-be about beliefs, telling the story of the various traditions I adhered to and let go of. Everyone has their own journey....
Both. Some traditions hinder progress along a spiritual path - through creating confusion or fear, particularly of change.
Some other traditions help spiritual progress by giving a guide to follow in order to reach certain points to make spiritual decisions.
Some traditions need to move with the times, and others need to stay as is. But they are all useful.
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A wise response, gratefully received.
I certainly think traditions are of great significance and should be examined carefully before abandoning them. My opinion concludes that Vatican II was a significant undermining of traditions and has weakened the universal church quite substantually. Re-discovering old Catholic traditions have accelerated my spiritual growth significantly... I certainly do not wish to impose the Latin Rite Mass on anyone; yet I believe for me, both this traditional Mass and the Sacraments have resulted in a significantly positive effect on my spiritual growth.
Perhaps another way to "look at this" is to remember this; "the quickest way forward is to go back"...
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Thank you for sharing from your journey.
I think we are surrounded by tradition. I do not consider myself traditional, but there is certainly pressure to conform to some traditions, especially around Christmas! That is why I usually try to go far away to some remote island. It gets me away from all the fuss and gifts of Christmas. On the other hand, I really wanted to marry in a church, and that is very traditional. Churches have many traditions of course, that is expected. But when I hear about truly sad events within churches, I have to question whether tradition actually enhances spirituality. I think I have come to the conclusion that tradition can be a sacred and respected thing, but it takes devoted and kind people to enhance spirituality, no matter what traditional religious rites they observe.Often tradition becomes blurred by commerce, and then there is no opportunity for it to enhance spirituality.
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Well said. Such discussions bring up many enriching thoughts and viewpoints. Thank you for participating.


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For if one is willing to listen to Socrates' arguments, they'd appear quite ridiculous at first; they're wrapped round on the outside with words and phrases like the hide of an outrageous satyr. He talks about packasses and smiths and cobblers and tanners, and forever appears to be saying the same things in the same ways, so that an inexperienced and unreasonable man might ridicule his arguments. But if the arguments are opened, and one sees them from the inside, he will find first that they are the only arguments with any sense in them, and next, that they contain within themselves utterly divine and multitudinous images of virtue, and that they are relevant to most or rather to all things worth considering for one who intends to be noble and good.
—Alcibiades' Speech, 222a, Plato, Symposium
Literature, real literature, must not be gulped down like some potion which may be good for the heart or good for the brain—the brain, that stomach of the soul. Literature must be taken and broken to bits, pulled apart, squashed—then its lovely reek will be smelt in the hollow of the palm, it will be munched and rolled upon the tongue with relish; then, and only then, its rare flavor will be appreciated at its true worth and the broken and crushed parts will again come together in your mind and disclose the beauty of a unity to which you have contributed something of your own blood.
—Nabokov, Lectures on Russian Literature, p. 105
No specific systems of analysis in these here hidden connections which I discovered while researching a very short piece I wanted to write—when Socrates saved Alcibiades' life at Potidaea—here there are just metaphors, but both of them essentially say, in their own way, to consider things slowly and closely, to look at what's taken for granted from new and different angles, to keep thinking and asking questions.
The paragraph on Potidaea will be forthcoming; far less analytical, far more action-packed.


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May 9, 2012
LOGAN, Utah - The Western Athletic Conference released its 2012 all-WAC softball teams today from Las Cruces, N.M., where the 2012 WAC Softball championship is being held. The all-WAC teams were selected by the league's head coaches. Utah State's junior infielder Christine Thomsen was selected to the first-team for her impressive 2012 campaign.
Thomsen finished the season batting .426 in conference games, with 29 hits, seven doubles and three home runs against WAC foes. She also posted a .982 fielding percentage, while manning first base, making her a defensive presence for her team as well. For the season, Thomsen batted .418 with a team high 66 hits to lead her team offensively. She posted a team-high 14 doubles to go along with 22 RBI and a .614 slugging percentage.
Thomsen is the 10th USU player to earn all-WAC honors since the Aggies joined the league in 2006. She is the fifth Aggie to earn first-team honors. Last season, freshman Allison Lenzora and Kassnadra Uchida were named to the second team. The last player to earn first-team honor was Nicole Rupp-Tindall in 2010.
"I am proud of Christine. When she joined our team this season I knew what type of player we were getting and she was able to showcase her talent every time she took the field. Christine worked hard this year and I am thrilled that she was recognized by opposing coaches and her peers for her hard work as well as her dedication to the game and our team."
Brigham Young's Delaney Willard was named WAC Player of the Year, while Hawai'i's Stephanie Ricketts was named Pitcher of the Year. Meanwhile, Hawai'i's Leisha Li'ili'i was named Freshman of the Year and UH's Bob Coolen was named Coach of the Year.
Hawai'i led the way with eight players on the all-WAC teams, followed by Brigham Young with five and Nevada with four. Five of the players were repeat selections from a year ago, while all eight schools were represented. The complete teams are listed below.
2012 ALL-WESTERN ATHLETIC CONFERENCE SOFTBALL TEAMS First Team Team Ht. Yr. Pos. Hometown (Last School) JC Clayton Brigham Young 5-5 Jr. SS Hollister, Calif. (San Benito) Jessica Dugas Brigham Young 5-4 Sr. CF Bellflower, Calif. (Mayfair) Makani Duhaylonsod Hawai`i 5-11 Sr. 1B Mililani, O`ahu (Mililani) Melanie Goff Louisiana Tech 5-9 Jr. SS/P Mira Mesa, Calif. (Grossmont) Jessica Iwata Hawai`i 5-4 Jr. SS Lihu'e, Kaua`i (Kaua`i) Kelly Majam Hawai`i 5-3 Jr. CF Pine Valley, Calif. (Mountain Empire) Michelle Moses Fresno State 5-9 Sr. RHP Paso Robles, Calif. (Paso Robles) Sara Parsons Nevada 5-9 So. OF Fallon, Nev. (Churchill County) Amanda Pridmore San Jose State 5-7 Jr. RHP Modesto, Calif. (Modesto) Stephanie Ricketts Hawai`i 6-0 Sr. RHP San Jose, Calif. (Archbishop Mitty) Sarah Robinson Hawai`i 5-8 Sr. 3B Honolulu, O`ahu (Moanalua) Christine Thomsen Utah State 5-8 Jr. 1B Fresno, Calif. (Colorado State) Delaney Willard Brigham Young 5-7 Sr. RF Camarillo, Calif. (Adolfo Camarillo)
Second Team Team Ht. Yr. Pos. Hometown (Last School) Alex Aguirre Hawai`i 5-5 Sr. LF Temple City, Calif. (Temple City) Tori Almond Brigham Young 6-1 So. RHP South Jordan, Utah (Bingham) Chelsea Barilli Nevada 5-5 Jr. OF Poway, Calif. (Poway) Michelle Cox San Jose State 5-6 Fr. OF Sydney, NSW, Australia Karley Hopkins Nevada 5-6 So. SS Reno, Nev. (Spanish Springs) Shaleese Javillo New Mexico State 5-5 Sr. 2B Kohala, Hawai`i (Kamehameha) Karlyn Jones Nevada 5-7 So. RHP Sparks, Nev. (Pitt) Leisha Li`ili`i Hawai`i 5-11 Fr. DP Kane`ohe, O`ahu (Castle) Katie Manuma Brigham Young 5-8 So. 1B Ewa Beach, Hawai`i (Campbell) Vonnie Martin Fresno State 5-5 So. 3B Plano, Texas (Plano) Courtney Moore Fresno State 5-5 Sr. DP El Sobrante, Calif. (MSU) Kaia Parnaby Hawai`i 5-6 Sr. LHP Bilgola Plateau, NSW, Australia Briana Tovio-Asato New Mexico State 5-8 Fr. 3B Kapolei, Hawai`i (Kapolei)
2012 WAC Player of the Year: Delaney Willard, Brigham Young 2012 WAC Pitcher of the Year: Stephanie Ricketts, Hawai`i 2012 WAC Freshman of the Year: Leisha Li`ili`i, Hawai`i 2012 WAC Coach of the Year: Bob Coolen, Hawai`i
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