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Hi, I'm working on some FP&A and Sales planning models and I am interested to hear how people have dealt with heavy foreign currency exposures? How have you accounted for uncertainty and volatility around assumed currency exchange rates?
My models assume over 50% non-dollar currency exposure so can this can have a big impact on my potential total revenue forecasted.
Please see two article below on Pfizer as a public reference:
Appreciate the communities thoughts!
Thank you
Solved! Go to Solution.
Hi I would suggest to have the forecast done in the transaction currencies, further have a model to see how the exchange rate for calculations were derived so we hit the nearest possible rates.
I would further suggest to have few versions and variances for those versions so we can know how much hit are gain are we going to get from the currency fluctuations and what would our plan B be to hedge the same.


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Many of you know by now that this is my last year doing ministry on campus with SCF. In fact, I'm now in my last month of doing full-time vocational ministry and will be transitioning into my new job starting sometime in May. This may come as a surprise and a shock to many of you, so I want to provide you with a little bit of a back story and then end by looking toward the future.
The Back Story
In August of 2013 I was presented with an opportunity to be part of a church plant to midtown Detroit and head up the campus ministry at Wayne State University. After thinking, praying, and talking about this with many people for a month, my wife and I felt like this wasn't the right opportunity for us. But what it did was set me on course for the next year and a half of praying and seeking the Lord for what was next.
Throughout that time, I thought about and considered many things: future campus ministry, seminary, pastoral ministry, and even opportunities outside of ministry. I was asking questions and praying through issues like: Where could I best serve the Lord, my family, and the church? How could I best use my gifts in service to the Lord's kingdom? My desire was to lay my life down before the Lord and say, "your will be done."
One morning in December, after spending extended time praying about my future, I received a call from one of my supporters asking if I'd be interested in interviewing for a job. At the time I wasn't sure, but I had just been praying about my future so I thought I had better at least look into this opportunity. After the interview I was surprised by how excited I was about the company and the position, which would allow me to pursue my interest in renewable energy (a major reason why I had studied Biosystems Engineering at MSU).
After that came more praying, more conversations, and a lot of waiting. Throughout that process I had peace and excitement to move forward if I was given an offer. In March I officially received the offer, and after discussing the situation again with friends and family, I officially accepted it.
Looking Forward
Leaving full-time vocational ministry is bittersweet. It's bitter because I will miss my colleagues that I've labored with on campus for the last five years; I'll miss the students that I've discipled and spent hours and hours with studying the Bible, praying, and hanging out; and I'll miss the up-front view I've had to see the Lord change lives in drastic ways on campus.
But it's also sweet. It's sweet because I'm leaving on good terms and with a good taste in my mouth. I still love my church (which I'll still be attending and serving), I still love my colleagues, I still love the students, and I still love doing ministry. It's not that I got burned out or disillusioned. No, but in many ways I love Jesus more, appreciate his church more, and am thankful for the gospel even more.
It's also sweet because this change is not from ministry to not-ministry. It's rather a shift in ministry, and it's exciting to trust the Lord for how he will lead my family and me and use us in this next phase of our lives.
We know from Scripture that we don't direct our own steps or lean on our own understanding or always understand our way, yet we do make plans, we do take steps, and we do it all while acknowledging God and trusting in him (cf Prov. 3:5-8, 16:1, 16:3, 16:9, 19:21, 20:24, Psalm 37:23, Jer. 10:23). It is God who establishes our steps and plans, who gives purpose, who provides answers, and who makes straight our paths. This year-and-a-half long journey has been a walk of faith to try to humbly walk with God while seeking wisdom for the future.
As I look forward to this new phase of life, my prayer is that I would be faithful to live the life that God has assigned to me and called me to (1 Cor. 7:17), that I would be diligent to use my gifts to serve his church (1 Pet. 4:10, Rom. 12:6), and that as I go I would be obedient to the call on my life as a believer in Jesus Christ to make disciples (Matt. 28:18-20).
To God be the glory!

subset: commoncrawl


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Search Collections
William Wilhelmi
Also Known as: William Merle Wilhelmi
Garwin, Iowa 1939
Active in:
- Corpus Christi, Texas
Luce Artist Quote
". . . Wilhelmi's work tells a story . . . evokes emotion . . . and comes to life. Each piece is a shaped composite of his life's experiences, expressing joy and appreciation for our rich culture and southern traditions." Lillian Murray, Exhibition catalogue for "The Clay's the Thing," The Art Museum of South Texas, March-June 1996
Luce Artist Biography
Bill Wilhelmi began his artistic training by taking every art course offered at San Diego State College from 1956 to 1960. The artist spent three years in the Navy, where he said he spent most of his time decorating officers' clubs, and after his discharge enrolled in a graduate program at UCLA. The art that Wilhelmi creates demonstrates a conscious movement away from the Japanese-influenced style that he was taught at school, and a development of a design that expresses his roots in Texas.


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Price: $2.99
(as of 2012-10-06 11:20:05 PST)
TEACH YOURSELF SYNCHRONICITY, DOWSING and SELF-HYPNOSIS (The Mental Magic series) by James F. Coyle
DescriptionThe author of this small book was the founder and CEO of the Australian Mindpower Research Foundation.
…… "Dowsing is the name given to the autonomous direct connection between your subconscious mind and the muscles of your hands. It is usually extremely difficult to extract information from your subconscious but with the use of dowsing you can, in certain instances, extract the information required by actually bypassing the interfering conscious mind. Sometimes with an amazing degree of accuracy. The process has been around for many thousands of years and there are various professional dowsers who make a good living out of it.
........ "Synchronistic events tend to reveal an underlying pattern, which is part of a larger unidentified event. Synchronistic events are regarded as signs and those who are aware consciously use them to make decisions in life. They can often give you a sense of direction to take to possibly avoid a disastrous situation. These days I pay close attention when I notice a series of apparently unconnected events that appear to exhibit a common purpose, almost always to my advantage!".......
......... "Self hypnosis was the tried and proven method of affecting the subconscious mind before Alpha and Theta states were discovered. Some people find it easier to use and learn than alpha/theta meditation techniques. With Alpha, Theta and Delta mind states you are able to fire your requirements out into the universe to be fulfilled eventually and manifested as material possessions and events. With self-hypnosis you are changing your inner core state to become the person you want. You are reprogramming your basic neural belief system. They are usually two totally different processes with two different end results."..........
This small easy-to-read book (with dowsing pictures) demonstrates the quickest possible way to learn these three disciplines.
Become a fan of Fish Eagle Publishing on Facebook for the inside scoop on latest and most exclusive books.


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Looks like Super Luxurious New 4BR House in Lake Jovita is no longer available on Rent.com which means this information is likely out of date.
Super Luxurious New 4BR House on Golf Course, 24h live guard gated
Luxurious, elegant, and beautiful Arthur Rutenberg's St Augustine VI model, 4BR+office/3.5BA/3Car/Pool, 3750sft under air condition. formal dinning, living, family room, breakfest area, 11"-14" ceiling heights, open floor plan, back to golf course, in gated golf course community - Lake Jovita. $3250/mo for rent. Open for rent or lease to purchase options ($250/mo will be credit to closing).
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This property is set in a quiet hamlet just 5 minutes drive to the picturesque village of Verteuil and 10 minutes drive to the market town of Ruffec. It is comprised of an entrance hall, kitchen/diner with woodburner, living room with woodburner, utility room and shower room/WC.... More details ›
Marketed by Compagnie Immobilière Charentaise, RUFFEC. Call: 0033545303531


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Second MBBS Alliance for Research and Training-SMART-2015
The School of Para-clinical Medical Sciences has conducted the National level activity of "Second MBBS Alliance for Research and Training", SMART-2015 on the 26th of August 2015 at D.Y. Patil Medical College Kolhapur. A total of 314 student delegates were registered for this one day event.
The event was inaugurated by Dr. Santosh Kakade the Chief Guest of the inauguration function. This was followed by the presidential address by Prof. Dr. S.H. Pawar, Vice-Chancellor of D.Y. Patil University. Thereafter the guest lecture by the Dr. Santosh Kakade on the topic of "Legal Boundaries of Medical Practice" discussed in detail. The legal issues of practicing Medicine and it was very informative for the students as well as the faculty members.
The overall event organization and Guest Lecture Invitation was looked after by the department of Forensic Medicine whereas the student activities in form of Essay competition was Organized department of Pathology, Poster Presentation by the department of Microbiology and lCMR-STS presentations by the department of Pharmacology. All the Teaching faculty, non teaching staff and the students of Second M.B.B.S. were actively involved in making this event a success.
Later in the evening a panel discussion was organized on ways to inculcate research in the Young medical graduates so as to boost medical research output of India.
The Chief Guest of the valedictory function was Dr. Arun Chougule, Dean, Faculty of Para-Medical sciences at Rajasthan University of Health Sciences, who shared his views on medical research with the delegates before giving away the prizes to the winners. All the events were appreciated by the students and the faculty who already were looking forward to attend the second M.B.B.S. student activity next year.


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- Adult Adventure
- Some Body Parts
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- Replacement Parts
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- Earlets & Tunnels
- Captive Bead Rings
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- Ear Plugs
- Genuine Diamond Jewelry
- Hide Your Piercing
- Organics
- Spirals & Claws
- Screwball Rings
- Circular Barbells
- Fixed Bead Rings
- Charms
Some Body Parts
Nipple Rounders$25.99Nipple Rounders are great additions to your nipple piercing. These effective jewelry pieces will put your nipples on a display in the most stylish way imaginable. A truly eye-catching jewelry piece with an edge! Learn More
Build Your Own Curved Barbell$26.99Build Your Own Curved Barbell is an elegant jewelry piece you can customize according to your needs. Choose between various ball sizes to create a truly personalized jewelry piece. This curved barbell is made of high-quality Surgical Steel and can be used for many different piercing types. Learn More
Big Ballin Straight Barbell$24.99Big Ballin Straight Barbell is an elegant jewelry piece you can customize according to your wishes. Choose the ball size you like the most and create your own, personalized jewelry piece. Suitable for almost any piercing type and available in many different sizes. Learn More
Titanium Internally Threaded Straight Barbell$30.99Titanium Internally Threaded Straight Barbell is a very elegant jewelry piece you can use for many different piercing types. The barbell is made of titanium and it's available in many different colors. Ideal for tongue, industrial, nipple and ear piercings! Learn More
Nipple Trainer$28.99The Nipple Trainer is a handy tool for stretching your nipple or just your nipple piercing. It is comfortable and very effective. You may use it to achieve long-term results. This nipple trainer can also be used for a temporary sensation and kinky games. Learn More
Titanium Big Balling Curved Barbell$26.99Titanium Big Balling Curved Barbell is an elegant jewelry piece with oversized balls. You can easily customize this barbell by choosing just the ball size you need. Create a truly eye-catching jewelry piece you can wear in almost any piercing! Learn More
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Build Your Own Titanium Circular Barbell$26.99Build Your Own Titanium Circular Barbell is an elegant jewelry piece you can customize according to your wishes. Choose the ball size you want and create your own, personalized jewelry that will sure attract a lot of attention! Learn More
Titanium Big Ballin Circular Barbell$26.99Titanium Big Ballin Circular Barbell is an eye-catching jewelry piece you will love to wear. This barbell comes with large balls so it will sure draw attention to your piercing. Customize your circular barbell with your choice of balls. Learn More


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Chaz Schilens was somewhat of an afterthought in 2008 when the Raiders drafted him in the seventh round of the NFL draft. He had been injured his senior season at San Diego State, the Raiders had already signed Javon Walker for the season, and Arman Shields was drafted by the team in the fourth round of the same draft. On top of all that, he'd have to compete with two other receivers drafted (Johnnie Lee Higgins and Jonathan Holland) in the 2007 draft.
Raiders at Chiefs postgame videos
The Oakland Raiders escaped what could've been a large setback in recent years. Their offense sputtered for only 166 total yards, while their defense allowed 409 to the Chiefs at Arrowhead Stadium on Sunday.
Raiders at Chiefs: Raider Rants Keys to the Game
Last week, the Oakland Raiders surprised many of the naysayers–including this one. From the start of their battle with San Diego until the end, the Raiders played so well that many left game concluding that they 'should have' won. Some have even considered the loss a victory of some sort.
One person not looking at it that way is Raiders' head coach Tom Cable. "We have nothing to be confident about other than our effort Monday night," said Cable on Friday to reporters. The key word from that statement is "effort." There's nothing in that statement about a win of any sort.
Current Raiders unfazed by Sapp's Showtime comments
As was reported at TFDSSports.com on Wednesday evening, Warren Sapp had plenty to say about the Oakland Raiders after week one–and none of it was complimentary.
The comments were made on Showtime's Inside the NFL, the long-running series that recaps the previous weekend in the NFL.
Raiders' trio of backs still nameless
Justin Fargas, Michael Bush, Darren McFadden, and even Louis Rankin–regardless who the Raiders have in the backfield, that back can make the defense pay for any mistakes it might commit.
There's only one problem. The Raiders can only start one of them at a time.
Raiders lose nail biter in final seconds
The Raiders were wearing uniforms from their AFL days, rushing the quarterback and stopping the run like they did when their legends were still on the field, scoring on long touchdowns as they did when they were perennial winners, but when they needed to play like their glory days the most, they looked more 2006 than 1976.
Cable confirms that Garcia wanted out
During a production meeting with ESPN for their Monday night contest with the San Diego Chargers, head coach Tom Cable revealed that he had misled beat writers on September 5, 2009, following the release of Jeff Garcia.
Chargers at Raiders: Raider Rants Keys to the Game
It's that time of year again, the time when Raider Nation's hopes are up and the Raiders are tied for the best record in the NFL–at 0-0.
After a rather quiet offseason, the Raiders began to make moves to shore up their run defense after they'd completed all of their OTA's. First, they signed Greg Ellis prior to camp. Ellis, the former Dallas Cowboys linebacker was promptly put into Derrick Burgess' left defensive end position.
Soon after the start of training camp, Derrick Burgess was traded to the New England Patriots for a third-round and a conditional fourth-round draft choice in 2010.
Four more rookies reported to have signed
The Oakland Raiders have reportedly signed four more undrafted rookie free agents. As of yet, none of the Raiders' free agent acquisitions have been confirmed by the team.
The four free agents reported to have agreed to terms are WR Chris Johnson (Tennessee State), TE Chris O'Neill (Boise State), LB Jerome Boyd (Oregon), and OG Jonathan Compas (UC Davis).
Raiders reportedly sign five undrafted rookies
The Oakland Raiders added a few more players to their stable of rookies on Monday with the signing of LB Frantz Joseph (FAU), LB David Nixon (BYU), WR Shawn Bayes (Kent St.), WR Nick Miller (So. Utah), and DE Desmond Bryant (Harvard).


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York S1-4770 - CONTROL ELECTRODE
York S1-4770 - CONTROL ELECTRODE
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Newark Neptune Shimmy is in the Arena Art Group show This Is Jazz at the Little Theater Cafe in Rochester, NY in June 2017
"It's an understatement to say that his work is engaging. It is bright, bold, sensuous, erotic, often challenging, always distinctive, meticulous and crafted. Brandwein is both painter and ceramicist. Biology in both popular and academic senses is a key to his work. As is geometry, his abstractions concerned with pattern, convexity, topology, the perfection of curve and line.
All of which misses the direct and immediate appeal of his work. Appeal, that is. to a wide often traditional audience...."
------Keith McFarlane, creator of Artportal Negative Entropy B.V.


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12/08/2017 Katsottu yhteensä: 13969 Tänään: 1
Chalet Tremalzo is located in Ledro. Complete with a dishwasher, the dining area also has a microwave. Private bathrooms also come with a shower. Extras include a barbecue and a fireplace. At Chalet Tremalzo you will find a garden. The property offers free parking. This holiday home is 55 km Verona Lentokenttä. (Chalet Tremalzo Ledro hotels varaamalla).


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- Trending Now: More Trending:
- Svengali syzygy hegemon repugnant white nationalist, white supremacist
put a damper on
Definition of put a damper on
: to make (something) less strong, active, or exciting His bad mood put a damper on the celebration. He was putting a bit of a damper on her spirits.
Word by Word Definitions
: to place in a specified position or relationship : lay
: to move in a specified direction
: to send (something, such as a weapon or missile) into or through something : thrust
: a throw made with an overhand pushing motion
: the act or an instance of putting the shot
: an option to sell a specified amount of a security (such as a stock) or commodity (such as wheat) at a fixed price at or within a specified time — compare call 3d
: being in place : fixed, set
: a dulling or deadening influence
: a device that damps: such as
: a valve or plate (as in the flue of a furnace) for regulating the draft
Learn More about put a damper on
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What made you want to look up put a damper on? Please tell us where you read or heard it (including the quote, if possible).


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Nan-E Nokhochi Persian Cookies
READY IN: 1hr 35mins
Recipe by Barbell Bunny
My favorite Iranian cookie! These are made from chickpea flour and have such a unique and lovely taste. They melt right in your mouth and are irresistible. They pair nicely with tea.
Ingredients Nutrition
- 3 1⁄2 cups chickpea flour, roasted
- 3⁄4 cup vegetable oil or 3⁄4 cup clarified butter
- 1 cup confectioners' sugar
- 3 teaspoons ground cardamom
- 1 tablespoon rose water
- 4 tablespoons crushed pistachios, for garnish
Directions See How It's Made
- Sift and combine the chickpea flour, confectioner's sugar, and ground cardamom.
- Add oil or butter and mix well.
- Add rose water, and continue to mix.
- Tightly pack the flour mixture into a small rectangular pan that is 3/4" deep.
- Cover with plastic wrap and refrigerate for one hour to harden the dough.
- Remove from the refrigerator.
- Preheat oven to 300 degrees.
- Cut the dough with a small cookie cutter (3/4" x 3/4". Traditionally a clover or flower cutout is used.).
- Place cookies on a baking sheet one inch apart.
- Garnish with crushed pistachios.
- Bake for 20-25 minutes, or until the base of the cookie is slightly golden.
- Allow the cookies to cool before transferring to a cooling rack or storage container. Be careful, as they are delicate.


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Palm City, Fla., March 21, 2017 – STS Component Solutions (STSCS), a division ofSTS Aviation Group, is proud to announce its new partnership with FW Marsh Energy Services for Aeroderivative Field Service Solutions. Read More!
Author Archives: Taylor Salisbury
STS Component Solutions Looks Ahead in 2017
As 2016 came to a close, STS Component Solutions ended a very successful year on a high note. Being able to reach sales goals, develop new relationships with valuable OEMs and build upon existing relationships with our customers and OEM partners were all achievements that made the year so amazing! Read More!
STS Component Solutions Hires Jim Naylor as its New Director of Sales-EMEA
Palm City, Fla., October 18, 2016 – STS Component Solutions (STSCS), a division of STS Aviation Group, is pleased to announce the recent hire of Jim Naylor as Director of Sales within the EMEA region. Jim will work remotely from the United Kingdom to further develop existing accounts as well as create new accounts for STSCS throughout the United Kingdom and Europe.
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Palm City, Fla., September 27, 2016 – STS Component Solutions, a division of STS Aviation Group, successfully acquires an LM2500 Aeroderivative Gas Turbine engine. This is the company's first LM2500 series engine purchase and further broadens STS' LM support capabilities. Read More!


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Posts Tagged 'technology'
Science Policy Around the Web – March 06, 2017
By: Liu-Ya Tang, PhD
Technology and Health
Is That Smartphone Making Your Teenager's Shyness Worse?
The development of new technologies, especially computers and smartphones, has greatly changed people's lifestyles. People can telework without going to offices, and shop online without wandering in stores. While this has brought about convenience, it has also generated many adverse effects. People tend to spend more time with their devices than with their peers. Parents of shy teenagers ask, "Is that smartphone making my teenager's shyness worse?"
Professor Joe Moran, in his article in the Washington Post, says that the parents' concern is reasonable. The Stanford Shyness Survey, which was started by Professor Philip Zimbardo in the 1970s, found that "the number of people who said they were shy had risen from 40 percent to 60 percent" in about 20 years. He attributed this to new technology like email, cell phones and even ATMs. He even described such phenomena of non-communication as the arrival of "a new ice age".
Contrary to Professor Zimbardo's claims, other findings showed that the new technology provided a different social method. As an example, teenagers often use texting to express their love without running into awkward situations. Texting actually gives them time and space to digest and ponder a response. Further, Professor Moran said that the claim of Professor Zimardo was made before the rise of social networks; shy teenagers can share their personal life online even if they don't talk in public. He also talks about the paradox of shyness, where shyness is caused by "our strange capacity for self-attention", while "we are also social animals that crave the support and approval of the tribe." Therefore, new technologies are not making the shyness worse, in contrast social networks and smartphones can help shy teenagers find new ways to express that contradiction. (Joe Moran, Washington Post)
Biologists Propose to Sequence the DNA of All Life on Earth
You may think that it is impossible to sequence the DNA of all life on Earth, but at a meeting organized by the Smithsonian Initiative on Biodiversity Genomics and the Shenzhen, China-based sequencing powerhouse BGI, researchers announced their intent to start the Earth BioGenome Project (EBP). The news was reported in Science. There are other ongoing big sequencing projects such as the UK Biobank, which aims to sequence the genomes of 500,000 individuals.
The significance of the EBP will greatly help "understand how life evolves", says Oliver Ryder, a conservation biologist at the San Diego Zoo Institute for Conservation Research in California. Though the EBP researchers are still working on many details, they propose to carry out this project in three steps. Firstly, they plan to sequence the genome of a member of each eukaryotic family (about 9000 in all) in great detail as reference genomes. Secondly, they would sequence species from each of the 150,000 to 200,000 genera to a lesser degree. Finally, the sequencing task will be expanded to the 1.5 million remaining known eukaryotic species with a lower resolution, which can be improved if needed. As suggested by EBP researchers, the eukaryotic work might be completed in a decade.
There are many challenges to starting this project. One significant challenge is sampling, which requires international efforts from developing countries, particularly those with high biodiversity. The Global Genome Biodiversity Network could supply much of the DNA needed, as it is compiling lists and images of specimens at museums and other biorepositories around the world. As not all DNA samples in museum specimens are good enough for high-quality genomes, getting samples from the wild would be the biggest challenge and the highest cost. The EBP researchers also need to develop standards to ensure high-quality genome sequences and to record associated information for each species sequenced. (Elizabeth Pennisi, ScienceInsider)
Have an interesting science policy link? Share it in the comments!
Science Policy Around the Web – January 6, 2017
By: Aaron Rising, PhD
Do You Want to Be a Superhero? Your Electronics Might Be Able to Get You a Little Closer to Being 'Wolverine'!
In a recent communication in the journal Advanced Material, and summarized in The Christian Science Monitor, researchers have designed a conductive material that has quite a number of uncanny attributes. It consists of polarized, stretchable, polymer chains that are connected via ion-dipole interactions. This material stretches well, tolerating "extreme strains exceeding 5000%", has high electrical conductivity, and is practically invisible.
What makes this material even more Incredible and Amazing is its ability to completely heal in 24 hours at room temperature. If cut with scissors, the ends will reconnect like new when placed in close proximity to one another. In talking with the Monitor, a co-author, Christopher Keplinger, described how we could go from metal robots like in Transformers to ones that look more like Data from Star Trek. "What you usually imagine is a metallic, clumsy piece of hardware that you would not want to have near yourself for any sort of collaboration or interaction – the mismatch in mechanics with the robot being hard and the human body being soft makes direct contact dangerous. Now imagine a new class of robots that are based on soft, elastic materials, being powered by stretchable electronic circuits and thus much more closely resemble the elegant design of biology."
While these materials won't make you invincible or heal like Wolverine they may make your cellphone or computer a little better at fighting crime or perhaps surviving being dropped. For a more global importance, this new material would allow for more suitable robotic human aids and caretakers. The use of robotic caretakers and companions has a rather large implication in both the health and the manufacturing sectors of our economy. (Joseph Dussault, The Christian Science Monitor)
We all know the major organs in our body, the heart, brain, lungs, stomach, etc. In fact, for well over 100 years medicine has stated we have 78 organs in total. These organs have been discussed and described in modern textbooks such as the 40th edition of "Gray's Anatomy" published in 2008. The editors of the prestigious textbook have revised the most recent version as a new organ called the mesentery has been found. It is located in and around the abdomen.
While discussed as early as 1885 by Dr. Frederick Treves and described as far back as 1508 by Leonardo da Vinci, the mesentery is a lining of the abdominal cavity that attaches to the intestine. This lining is what keeps the intestines in place in our gut. Treves described the mesentery 'existed only sporadically, in disjointed ribbons, dispersed among the intestines and therefore did not meet the definition of an organ'. And as such was not and has not been classified as one of the 78 organs.
Two Irish scientists, however, disagreed and have claimed that the mesentery was not correctly categorized. According to Dr. J Calvin Coffey and Dr. D Peter O'Leary in The Lancet Gastroenterology & Hepatology, the mesentery can really be described as a single and continuous tissue and thus can be classified as an organ. First summarized in the Independent and subsequently in Discovery Magazine and The Washington Post, the new organ's function isn't entirely understood. Talking to the Independent Dr. Coffey said, "Now we have established anatomy and the structure. The next step is the function. If you understand the function you can identify abnormal function, and then you have disease. Put them all together and you have the field of mesenteric science."
This new discovery opens up the possibility that some gastrointestinal ailments that have previously been associated with one organ, such as the stomach, may in fact be more aligned with the mesentery. Because the function of the mesentery is largely unknown, drug companies have a new target to test drugs and academic and government research groups have a complete new system to study. How to appropriately tackle the funding and attention this new organ and the emerging 'mesenteric science' will receive is just now being examined. (Tom Embury-Dennis, Independent)
Have an interesting science policy link? Share it in the comments!
Entrusting Your Life to Binary: The Increasing Popularity of Robotics in the Operating Room
By: Sterling Payne, B.Sc.
Minimally invasive surgery has been around since the late 20th century, however, technological advancement has sent robotic surgeons to the forefront of medicine in the past 20 years. The term "minimally invasive" refers to the performance of a surgery through small, precise incisions a far distance away from the target, thus having less of a physical impact on the patient in terms of pain and recovery times. As one can imagine, surgeons must use small instruments during a minimally invasive procedure and operate with a high-level of control in order to perform a successful operation. In light of these requirements, and due to fast-paced advances in robotics in the last decade, robots have become more common in the operating room. Though their use benefits all parties involved if used correctly, several questions of policy accompany the robotic advance and the goal of fully autonomous surgery.
The da Vinci system is one of the most popular devices used for minimally invasive surgeries, and was approved by the FDA in 2000 for use in surgical procedures. The newest model, the da Vinci Xi® System, includes four separate robotic arms that operate a camera and multiple arrays of tools. The camera projects a 3D view of the environment onto a monitor for the surgeon, who in turn operates the other 3 arms to perform highly precise movements. The da Vinci arms and instruments allow the surgeon more control over the subject via additional degrees of freedom (less restricted movement), and features such as tremor reduction.
Though the da Vinci system is widely used, its success still depends on the skill and experience of the operator. Surgical robotics engineer Azad Shademan and colleagues acknowledged this in a recent publication in Science, highlighting their successful design, manufacturing, and use of the Smart Tissue Autonomous Robot (STAR). The STAR contains a complex imaging system for tracking the dynamic movement of soft tissue, as well as a custom algorithm that allows the robot to perform a fully autonomous suturing procedure. Azad and colleagues demonstrated the effectiveness of their robot by having it perform various stitching procedures on non-living pig tissue in an open surgical setting. Not only did the STAR succeed in both procedures, it outperformed highly experienced surgeons that it was pitted against. More information on the STAR can be found here.
In response to the da Vinci system, Google recently announced Verb Surgical, a joint-venture company with Johnson & Johnson. Verb aims to create "a new future, a future unimagined even a few years ago, which will involve machine learning, robotic surgery, instrumentation, advanced visualization, and data analytics". Whereas the da Vinci system helps the surgeon perform small, precise, movements, Verb will use artificial intelligence amongst other technologies to augment the surgeon's view, providing information such as anatomy and various boundaries of bodies such as tumors. A procedure assisted by the da Vinci system can increase the physical dexterity and mobility of the surgeon, however, Verb aims to achieve that and give a "good" surgeon the knowledge and thinking modalities previously confined to expert surgeons gathered over time through hundreds of surgeries. In a way, Verb could level the playing field in more ways than one, allowing all surgeons access to a vast knowledge base accumulated through machine learning.
As proven by the introduction of fully self-driving cars by Tesla in October, autonomous robots are becoming integrated into society; surgery is no exception. A 2014 paper in the American Medical Association Journal of Ethics states that we can apply Isaac Asimov's (author of I, Robot) three laws of robotics to robot-assisted surgery "if we acknowledge that the autonomy resides in the surgeon". However, the policy discussion for fully autonomous robot surgeons is still emergent. In the case of malpractice, the doctor performing the operation is usually the responsible party. When you replace the doctor with an algorithm, where does the accountability lie? When a robot surgeon makes a mistake, one could argue that the human surgeon failed to step in when necessary or supervise the surgery adequately. One could also argue logically that the manufacturers should claim responsibility for a malfunction during an automated surgery. Other possibilities include the programmer(s) who designed the algorithms (like the stitching algorithm featured in the STAR), as well as the hospital housing the robot. This entry from a clinical robotics law blog highlights the aforementioned questions from a litigator's standpoint.
A final talking-point amidst the dawn of autonomous surgical technology is the safeguarding of wireless connections to prevent "hacking" or unintended use of the machine during telesurgery. Telesurgery refers to the performance of an operation by a surgeon who is physically separated from the patient by a long distance, accomplished through wireless connections, at times open and unsecured. In 2015, a team of researchers at the University of Washington addressed the weaknesses of the procedure by hacking into a teleoperated surgical robot, the Raven II. The attacks highlighted vulnerabilities by flooding the robot with useless data, thus making intended movements less fluid, even forcing an emergency stop mechanism. Findings such as this will help with the future development and security of teleoperated surgical robots, their fully autonomous counterparts, and the policy which binds them.
When a web browser or computer application crashes, we simply hit restart, relying on autosave or some other mechanism to preserve our previous work. Unlike a computer, a human has no "refresh" button; any wrongful actions that harm the patient cannot be reversed, placing a far greater weight on all parties involved when a mistake is made. As it stands, the policy discussion for accountable, autonomous robots and algorithms is gaining much-needed momentum as said devices inch their way into society.
Have an interesting science policy link? Share it in the comments!
Science Policy Around the Web – October 28, 2016
By: Emily Petrus, PhD
Technology and Health
As digital media screens have become more prevalent, doctors have warned parents of its negative impact on developing minds. In 1999, screen time was first addressed, with doctors mandating that no screen time was recommended for children under age 2. The argument goes that children need parents present in real-time to interact with to develop the ability to read social cues and engage on a personal level.
Now the American Academy of Pediatrics (AAP) has dictated that one hour per day of high-quality educational screen time may be allowed for children between 2 and 5 years of age. For children 18 months to 2 years, some screen time is ok as long as a parent is actively engaged and watching with the child. This is especially relieving for parents of children who have relatives far away who use Skype or FaceTime to communicate. Although this is technically screen time, it does benefit children with those important social interactions and reading facial and vocal cues.
Overall the goal of the AAP is to ensure that media is used in a mindful way, not to replace social interactions but to enhance family discussions and provide supplementary education material for older age groups. They also recommend media-free family time to ensure children develop a healthy relationship with technology. Jenny Radesky, MD, FAAP and lead author for the statement said, "What's most important is that parents be their child's media mentor. That means teaching them how to use it as a tool to create, connect and learn." In relation to screen time rules, it seems the amount of parent involvement and moderation are the keys to success. (AAP)
Mental Health Research
New Director of National Institutes of Mental Health (NIMH)
NIMH has a tall order to fill: bridge the gap from the breakneck speed of basic neuroscience research advances to bring solid and reliable treatments to the clinic. Last month NIMH welcomed a new director, Dr. Joshua Gordon, to take the helm and direct the institute toward a balance between these two priorities. After 19 years as a faculty member at Columbia University, Gordon hopes to bring his experience as both a clinician and a researcher to achieve this delicate result.
NIMH's strategic plan for research was laid out in September, with four priorities highlighted to combat mental illness. These include describing mechanisms of complex behaviors, at the molecular, cellular, circuit and genetic levels. Second, characterizing mental illness trajectories to determine best intervention procedures and time points, which would include detecting biomarkers and understanding how behavior reflects neuropathology. Third, NIMH strives to marry tried and true existing treatments with new therapies which can be implemented in community settings, thus bringing help to patients. Finally, NIMH funded research must improve public health, with better clinician education about new treatments, and new service delivery models that can be implemented to reach more patients suffering from mental illness.
These are all monumental tasks but Gordon seems up for the challenge. In a recent Q&A session by Meredith Wadman of Science Magazine, he was asked about the op-ed pieces in the Washington Post and the New York Times by NIMH clinical psychiatrists where they accused previous director Thomas Insel of putting too much priority on basic research and letting clinical neuroscience fall by the wayside. Gordon replied by saying, "I think my first priority is good science. Where there are opportunities in psychiatry for short-term effects, we are going to try to take advantage of them. Absolutely. We'd be mad not to. We know so little about the brain, we have so few truly novel treatments in the pipeline that I'm all ears." (NIH News Release)
Autism early intervention – help the parents, help their children
The plight of the working parent has become an important and almost bipartisan issue this election season. Politicians are proposing policies that will help families with paid family leave and some help with childcare costs, however there is a growing segment of people who desperately need even more help. Raising a child with autism is increasingly common, currently 1% of children and young people in the US are on the spectrum.
The cost of having an autistic child can be tremendous, with extra health care expenses, special equipment, classes and educational requirements. Often one parent must leave the workforce to care for their child as they require extensive and specialized care. Early interventions such as classes and therapy are thought to be effective for lessening the symptoms of autism, but until now the trials have been small and have had short end points. This week The Lancet published an article demonstrating that interventions aimed at educating parents of autistic children had long-term (up to 6 years) benefits. 152 children aged 2-4 years old were recruited to the study, with half given interventions that included therapy, monthly support and a parent-mediated 20-30 minute daily session of planned activities. The children who received this extra support reported lower levels of severe autism and had better teacher and parent assessed behaviors. However, the study did not find significant reductions in anxiety or depression or a language benefit.
This study demonstrates that providing education and resources for parents of autistic children are a worthwhile endeavor. Government resources are often aimed at providing services for the child, which are equally important. Parents armed with the proper educational tools can become personalized therapists for their children, which could reduce societal costs and improve outcomes. (Heidi Ledford, Nature)
Have an interesting science policy link? Share it in the comments!
Synthetic Biology and Biodefense: Regulating the Unknown
By Rebecca Cerio
The field of synthetic biology–most broadly described as the design and construction of new biological functions and systems not found in nature–has been quietly advancing ever since the discovery of restriction enzymes in the 1970s. Being able to cut-and-paste DNA segments in combinations different than those created by nature opened the door to molecular biology and the burgeoning biotechnology field. Such technologies, as well as our understanding of DNA functional and regulatory elements, now allow us to genetically engineer organisms to produce needed medicines, to bioengineer pest- and chemical-resistant food crops, and to sequence and study the genome of any organism for useful and harmful mutations.
Recently, the J. Craig Venter Institute's announcement that they can chemically synthesize an entire, functional genome in the lab has led to new public awareness of the potential power, benefits, and dangers of synthetic biology. One question raised is: just because we can, does that mean that we should?
Or, from a regulatory standpoint, just because it is possible, should it be allowed? Synthetic biology technology can be used for legitimate scientific purposes (i.e., producing vaccines) and to threaten public safety (i.e., producing deadly pathogens). But what are the actual, plausible risks and benefits of synthetic biology, beyond movie-plot scenarios and inflammatory rhetoric about "playing God"? Read the rest of this entry »


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- J C Willoughby, L M Glidden
- American journal of mental retardation : AJMR
- 1995
The relation between division of child care and marital satisfaction in couples rearing children with disabilities was explored. Greater father participation in child care was related to higher marital satisfaction for both parents. Higher family income was also related to higher marital satisfaction for fathers only. Results were discussed in the framework… (More)
- Stephen J Sheinkopf, Peter Mundy, Angelika H Claussen, Jennifer Willoughby
- Development and psychopathology
- 2004
This study examined whether infant joint attention (JA) skills predicted social behaviors in a sample of at-risk preschool children (n = 30) with a history of prenatal exposure to cocaine. JA behaviors were assessed with the Early Social and Communication Scales at 12, 15, and 18 months of age. Three classes of JA were measured: Initiating JA (IJA),… (More)
- Angelika H Claussen, Peter C Mundy, Sangeeta A Mallik, Jennifer C Willoughby
- Development and psychopathology
- 2002
The development of joint attention skills is a major milestone of infancy. Recent research suggests that the development of these skills may be affected by disorganized (D) attachment. This hypothesis was examined in a longitudinal study of attachment and joint attention skill development in a sample of infants at risk for developmental-behavioral… (More)
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