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Hurel Corporation
Hurel Corporation
Hurel Corporation | Date: 2017-07-12
An in vitro methods of characterizing biliary excretion of a chemical entity using a single hepatocyte culture. Comprising providing cell culture comprising hepatocytes forming at least one bile canaliculus; contacting the cell culture with a first chemical entity for a time sufficient to allow uptake of the chemical entity by hepatocytes in the culture; disrupting the at least one bile canaliculus without lysing the hepatocytes and detecting the amount (if any) of the first chemical entity and/or a metabolite thereof released by the at least one bile canaliculus; and lysing the hepatocytes and detecting the amount of the first chemical entity and/or a metabolite thereof released by the hepatocytes.
Hurel Corporation | Date: 2017-06-28
Primary mammalian cell culture systems, methods of making primary mammalian cell culture systems, and methods of culturing primary mammalian cells are provided. In some embodiments the systems and methods utilize an exothermic chemical process as a heat source for culturing and shipping cultures comprising primary mammalian cells.
News Article | October 28, 2016
Site: www.marketwired.com
LOS ANGELES, CA--(Marketwired - Oct 24, 2016) - Stellar Biotechnologies, Inc. ( : SBOT), the leader in sustainable manufacture of a key protein utilized in multiple immunotherapy development pipelines targeting cancers, Alzheimer's and lupus, among other diseases, announced today that Gregory T. Baxter, PhD, will join the company's management team in the new role of Executive Vice President of Corporate Development, effective December 1, 2016. Dr. Baxter, a current member of Stellar's Board of Directors and its Scientific Advisory Board, will lead the company's corporate development activities, including joint ventures and business development, as well as the expansion of Stellar's production and manufacturing capabilities. Stellar previously announced the development of a second production site in Baja California, Mexico and a joint venture, Neostell S.A.S., with French partner Neovacs S.A. for manufacturing immunotherapy products for Neovacs and potentially other third-party customers utilizing KLH-based therapeutic vaccines. "Greg's in-depth understanding of our business and extensive business experience in biotechnology, pharmaceutical drug development and aquaculture make him a uniquely qualified choice to support our growth opportunities," said Stellar President and CEO Frank Oakes. "He will take the lead oversight role in our Neostell joint venture and guide our strategic planning and operations." Dr. Baxter is a published author and holds over 20 patents on various aspects of molecular biology and biochemistry, and has served as an executive and scientist for several biotechnology corporations and foundations. Since 2001, he has been a Senior Scientist in the Department of Clinical Drug Development for CCS Associates, Inc. He also serves as Adjunct Associate Professor at Cornell University in the College of Chemical Engineering and on the Founders Board of Stanford University's StartX Med Program. Dr. Baxter's background spans both science and business arenas including Program Director for the National Science Foundation (NSF) Division of Industrial Innovation and Partnerships; Founder and CSO of Hurel Corporation; Founder and CEO of Aegen Biosciences; and Research Scientists for Molecular Devices Corporation. Dr. Baxter received his PhD in Biochemistry/Molecular Biology from the University of California, Santa Barbara. Dr. Baxter said that Stellar provides an exciting opportunity to work in a pivotal area for multiple indications. "KLH-conjugated vaccines have demonstrated great promise and our collaborators have a number of exciting clinical milestones ahead. I look forward to advancing the sustainable production and manufacturing of GMP-grade KLH and paving the way for more KLH-based approaches to immunotherapy," he said. About Stellar Based north of Los Angeles at the Port of Hueneme, Stellar Biotechnologies, Inc. ( : SBOT) is the leader in sustainable manufacture of Keyhole Limpet Hemocyanin (KLH), an important immune-stimulating protein used in wide-ranging therapeutic and diagnostic markets. KLH is both an active pharmaceutical ingredient (API) in many new immunotherapies (targeting cancer, immune disorders, Alzheimer's and inflammatory diseases) as well as a finished product for measuring immune status. Stellar is unique in its proprietary methods, facilities, and KLH technology. The company is committed to meeting the growing demand for commercial-scale supplies of GMP grade KLH, ensuring environmentally sound KLH production, and developing KLH-based active immunotherapies. Stellar Forward-Looking Statements This press release may contain forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. Forward-looking statements may be identified by the use of words such as "anticipate," "believe," "plan," "estimate," "expect," "intend," "may," "will," "would," "could," "should," "might," "potential," or "continue" and variations or similar expressions. Readers should not unduly rely on these forward-looking statements, which are not a guarantee of future performance. There can be no assurance that forward-looking statements will prove to be accurate, as all such forward-looking statements involve known and unknown risks, uncertainties and other factors which may cause actual results or future events to differ materially from the forward-looking statements. Such risks include, but may not be limited to: general economic and business conditions; technology changes; competition; changes in strategy or development plans; availability of funds and resources; governmental regulations and the ability or failure to comply with governmental regulations; the timing of Stellar's or its partners' anticipated results, including in connection with clinical trials; the ability to meet the goals of Stellar's joint ventures and strategic partnerships; and other factors referenced in Stellar's filings with securities regulators. For a discussion of further risks and uncertainties related to the Stellar's business, please refer to the Stellar's public company reports filed with the U.S. Securities and Exchange Commission and the British Columbia Securities Commission. All forward-looking statements are made as of the date hereof and are subject to change. Except as required by law, Stellar assumes no obligation to update such statements. This press release does not constitute an offer or solicitation of an offer for sale of any securities in any jurisdiction, including the United States.
Novik E.,Hurel Corporation |
Maguire T.J.,Hurel Corporation |
Chao P.,Hurel Corporation |
Cheng K.C.,Schering |
Yarmush M.L.,Harvard University
Biochemical Pharmacology | Year: 2010
Within the global pharmaceutical and biotech industries, there is significant interest in identifying in vitro screening systems that are more human-relevant-i.e., that offer greater utility in predicting subcellular and cellular physiological responses in humans in vivo-and that thereby allow investigators to reduce the incidence of costly late-stage failures during pharmaceutical clinical trials, as well as to reduce the use of animals in drug testing. Currently incumbent in vitro screening methods, such as culturing human hepatocytes in suspension, while useful, are limited by a lack of long term cellular function. In order to address this limitation, we have established an integrated, microfluidic, in vitro platform that combines the patented HmREL1 microdevice with a hepatic coculture system. In the present report, we use this platform to study clearance and metabolite generation of a battery of molecular entities. The results show that the flow-based coculture system is capable of clearing, with improved resolution and predictive value, compounds with high, medium, and low clearance values. In addition, when coculture is coupled with flow, higher metabolite production rates are obtained than in static systems.© 2009 Elsevier Inc. All rights reserved.
Hurel Corporation | Date: 2011-10-13
Hurel Corporation | Date: 2012-01-04
cells, cell constructs, tissues, tissue constructs, cell or tissue constructs comprising man-made or bioengineered biochemical materials, constructs of naturally occurring biochemical materials; media for culturing cells, tissues, man-made, bionengineered, or naturally occurring biochemical materials or constructs configured therefrom; platforms, networks or systems comprising cells, tissues, man-made, bionengineered, or naturally occurring biochemical materials or constructs configured therefrom; assays, readouts, transducers or sensors for detecting signals from cells, tissues, man-made, bionengineered, or naturally occurring biochemical materials or constructs configured therefrom, or platforms, networks or systems comprising any of the foregoing; or computer software, computer programs, or information databases for storing, analyzing, interpreting, or presenting information relating to any of the foregoing.
Hurel Corporation | Date: 2015-02-26
Tissue cultures, buffering solutions, and associated analytic methods suitable for measuring the uptake of proteins and other chemical entities into cells, and the efflux of proteins and other chemical entities out of cells, including without limitation with respect to hepatobiliary cells.
Hurel Corporation and General Hospital Corporation | Date: 2016-01-20
Compositions and methods described herein provide a cell culture system in which cells are in high metabolic states from the onset of the culture. Combinations of various cell culture components disclosed and employed herein allow cells to be in high metabolic states useful for drug testing immediately after the start of cell culture.
Hurel Corporation | Date: 2015-09-02
An in vitro methods of characterizing biliary excretion of a chemical entity using a single hepatocyte culture. Comprising providing cell culture comprising hepatocytes forming at least one bile canaliculus; contacting the cell culture with a first chemical entity for a time sufficient to allow uptake of the chemical entity by hepatocytes in the culture; disrupting the at least one bile canaliculus without lysing the hepatocytes and detecting the amount (if any) of the first chemical entity and/or a metabolite thereof released by the at least one bile canaliculus; and lysing the hepatocytes and detecting the amount of the first chemical entity and/or a metabolite thereof released by the hepatocytes.
Hurel Corporation | Date: 2010-01-05
Flow cytometers and flow-based analyzers providing cell and particle analysis, detection, and counting for scientific, laboratory, and general research uses; Plates, glass slides and chips having multi-well arrays that can be used in chemical analysis, biological analysis and patterning for scientific, laboratory and medical research use; Reaction systems for catalyst research.


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Camp Sites in Wroxham
Visit the Norfolk Broads and stay in a camp site in Wroxham. Wroxham is famous for being the heart of the Norfolk Broads, and attracts thousands of visiting tourists wanting to explore the delights of this unique wetland park. Wroxham is located on the A1151, north-east of Norwich. There is a regular train service from Norwich that stops at Wroxham/Hoveton station.
Staying at a camp site in Wroxham is perfect to explore the rest of the Norfolk Broads from, on the River Bure. Wroxham offers a wide range of facilities for a Norfolk Broads town, including 'Roys of Wroxham'; a large department store as well several pubs and few good restaurants to dine out.Wroxham is a great way to enjoy a family camping holiday in Norfolk and experience the delights of the Norfolk Broads. For more information on Camp Sites in Wroxham - please click on the link below:
Camping on Salhouse Broad
For relaxed, friendly countryside camping, Salhouse Broad on the Norfolk Broads is the perfect place to stay and enjoy your holiday with friends and familyread more visit website contact
Glamping Pods on Salhouse Broad
Fancy something more simple and more solid than a tent? All you need to do is turn up with a roll mat and sleeping bag.....Why not try our Pod!read more visit website contact
Camping at Salhouse Lodge
Salhouse Lodge is set in the heart of the Norfolk Countryside yet just a mile from Wroxham the capital of The Broads and 5 mile from Norwich .read more visit website contact

subset: commoncrawl


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HPI Racing Light Weight Steel Spur Gear 53T (Hellfire)
HPI Racing
This item is discontinued and no longer available for purchase. You may want to search our site for a similar item.
|Low Price:
Discontinued Online
This is the optional replacement 53T light weight spur gear for the HPI Hellfire Monster Truck. The spur gear attaches to the center differential and provides power from the engine clutch bell and transfers it to the center drive train. This light weight spur gear is a great way to shed weight from your truck.
This product was added to our catalog on May 8, 2006.


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Featuring over 75 schools, Live Stream delivers exclusive coverage with customization and DVR functionality, to any of your screens.
Over 30 different Men's and Women's sports. 15,000 live events per year. NCAA Championship coverage. NFL & NCAAF Live is the most comprehensive collegiate sports streaming product available.
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We provide 100% satisfaction guarantee to our subscribers.If you are not satisfied with your purchase, just let us know and we will cancel the subscription at any time with 7 days Money back Guarantee.


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Monthly Archives: September 2015
Catching up with Larry Smith
I talked to Larry Smith earlier this summer about his Six Word Memoirs project and the Columbus variant, Six in the City. He had a booth at the 2015 Columbus Independents' Day Festival and I got an update on his plans. … Continue reading
Posted in Craft guest follow up, Creativity, Original Craft Productions Comments Off on Catching up with Larry Smith
I Hulk Out with Lou Ferrigno
The Columbus Comic Con is upon us! I'll be attending doing interviews, so say "hi" if you see me. Below is a sneak peak of the Con with Lou Ferrigno, the original Hulk. I remember watching this show as a … Continue reading
Posted in Original Craft Productions Comments Off on I Hulk Out with Lou Ferrigno
How Do You Pronounce Sumukh Torgalkar?
His new album "The Mispronunciation of Sumukh Torgalkar" (iTunes) was a hit on iTunes Comedy and Sumukh Torgalkar has been touring around the country from his base in Columbus, Ohio, as well as at the Arch City Comedy Festival. Listen in … Continue reading
Posted in Comedy, Original Craft Productions Tagged Comedian Sumukh Torgalkar, itunes comedy album Comments Off on How Do You Pronounce Sumukh Torgalkar?
How Well Do You Know Paula Poundstone?
You've heard her on "Wait, Wait Don't Tell Me," seen her HBO comedy special, or watched her animated character "Forgetter Paula" in Disney Pixar's "Inside Out." But how well do you really know Paula Poundstone? Listen to our interview so you … Continue reading
Posted in CAPA, Comedy, Original Craft Productions Tagged Disney Pixar's Inside Out, Paula Poundstone, Wait Wait Don't Tell Me Comments Off on How Well Do You Know Paula Poundstone?
Erin Foley: Outside Her Comfort Zone
Comedian Erin Foley, appearing in Columbus on September 3-5 with the Arch City Comedy Festival, has done many things: toured extensively as a stand up comedian, hosted the popular podcast Sports without Balls, and released a CD, Lady with Pockets. But when … Continue reading
Posted in Original Craft Productions Tagged comedy, Erin Foley, erotic fan fiction Comments Off on Erin Foley: Outside Her Comfort Zone


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Our painting and sculpture classes cater to art students of all levels across a wide range of mediums including: oil, pastel, watercolour, acrylic, gouache and sculpture. Lessons cover a range of techniques, such as drawing, contemporary, portraiture, landscape, still life and life model.
Students need to be 18 years and over to enrol in our classes.
Art classes must be paid in full in advance.
Please choose carefully when selecting a class, as we do not offer refunds or transfers except under special circumstances.
Term 3 classes will be available for bookings from Monday 19th June 2017.


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vintage photos of people in cape town in the early sixties
some of my favourite shots from a wee photo session at nook the other day
hello fox
angie & her friend jo have created all this amazing handmade jewellery for the Charity Angel's flea market Bedfordview Pre-Primary School – 22 Kings Road Bedfordview (across from St Benedicts), 10am to 3pm on sunday the 6 December, THIS sunday. if you're in the area code go buy some stuff…
i want to go to there
holy moly, it's only 18 odd days and then my SUMMER HOLIDAY starts. today i'm reflecting on summer holidays of old, 99.9% of the time spent by the sea (where else?). our family haunts were: knysna: when i was very small, we went camping in knysna. i don't remember much…
look at nook
oh YAY Jessica & Luke's restaurant Nook has been featured in the December issue of House & Leisure! so excited & proud of them, if you guys haven't visited yet – please do
boogie woogie board
sunset and waves at kogel bay
kagga kamma
i want to go to there.
i've watched this advert a multitude of times, but decided to share anyway for those of you who might have missed it.
the dudes in my family went on a big bad bike trip through the karoo this past weekend.
latest pics of the new 2010 stadiums from the official 2010 twitter feed – nice!
ooooooh i'm hoping for the entire alphabet! go haasbroek go go go.
spring day, 1990
every spring day (sept 1st) at our primary school there would be a 'spring hat' competition for the younger kids.
steri stumpie
first steri stumpie billboard ever, how classic! for those non-afrikaans speakers, the headline reads "we flavour milk". simple, to the point – i like that. i would have loved to drink my steri stumpies from glass bottles, too – industry people take note. strawberry geur for me, please. from the…
& Union
sausage, meat, mustard & great poster design all in one. good beer too, so i hear – & Union.
& the
ooooooh my favourite SA band Desmond & The Tutus has a new EP out Everyone that signs up today or before today gets a free download of the EP http://www.andthe.co.za/


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At your seasonal event, at every table, this Snowflake Place Card Holder is destined to be the handiest hit of any winter occasion, giving your guests a choice of uses when they take it home. The stand on the back of the snowflake creates the iconic place card holder for your winter-themed table decor. With its elegant black ribbon, the silver-tone, beautifully designed snowflake becomes a keepsake ornament. And of course, the magnet on the back lets your guests attract a snowfall wherever they wish. :Silver-tone snowflake place card holder with stand can also be displayed as a magnet or hung as an ornamentFeatures a magnet on the back and black satin ribbon for easily display in the home or officeMeasures 3 3/4" x 3 3/4"Sold as a set of four
Rarely has there been a favor designed with such classic elegance. The artists at Kate Aspen have created this fashionable photo frame in 17th-Century Italian baroque style, where architecture, painting, sculpture, and the decorative arts combine to capture finely detailed movement. Whatever it holds—a place card or your favorite photo, our captivating baroque frame graces your tables with grandeur. : Intricately designed, glossy black-resin Baroque photo frame Black back and vertical stand with easy-open access to photo space Frame has 2 ½ " h x 1 ¾ " space for photo or place card Insert with coordinating accent can be used as a place card Baroque frame measures 4 ¾ " h x 3 ½ " w
Let a nostalgic expression of days gone by lead the way to your happy occasion. Guests will feel like they are in a historic place full of old-world charm as this clever streetlight favor shows them the way to their seats with a place card that looks like a street sign. Delightfully unique! : Gracefully crafted, metal-and-resin streetlight is black with painted, white "glass" windows in the lamp Streetlight measures approximately 4 1/4" h x 3" w (with place card) Place card with scroll design included Sold in a set of four Featured in BRIDES magazine
Vintage charm meets utterly unique in Kate Aspen's Victorian key that holds place cards and photos. A fabulous favor is the key to a memorable thank-you gift, and this intricately crafted key is designed to unlock memories! :Antique-gold-finish, resin Victorian-style key with slit for place cardKey measures approximately 3 1/4" h x 1 1/4" wCoordinated place cards includedSold in a set of four
Create the perfect seaside atmosphere by showing your guests to their seats with these beautiful authentic shell holders. Each dainty, shiny shell holds a place card and guests can later use these keepsake shells to hold their own photos. A perfect memento for seaside events! Features & Facts: Sold as a set of 6 Matching designer place cards included Because these are real sea shells actual size and shape may vary
Just the favor for the love-filled, mellow mood you want at your wedding! Kate Aspen's woodsy, heartwarming place card/photo frame has a quaint charm that people appreciate, and it brings the old and the new happily together. :Square, resin frame with light, faux wood print and a heart-shaped space for a photoBlack back and frame standPhoto space is 2 1/8 h x 2 1/8" h (in heart shape)Photo frame measures approximately 3" square
Featuring a little bit of elegance and boho chic in one beautiful package, Kate Aspen's Gold Laurel Place Card Holder is perfect to use as you're helping guests find their seats at your botanical garden wedding! Whether your wedding is taking place in a beautiful backyard garden or in a classy ballroom, the antique gold finish is sure to complement your decor. You could even use them to display photos, or the buffet's selections. :Resin place card holder is an antique gold round wreath with a backer. Place card is white with a think gold foil line across the topPlace card holder measures 1.1" w x 0.86" d x 3.22" h; place card measures 2.24" w x 0.03" d x 2.12" hSold in a set of 6Packaged gift ready in a white box
You want your place cards to be noticed, and we have just the piece to help them catch the eye! Kate Aspen's Silver Seashell Place Card Holders are the perfect place card holder to use for your beach wedding or destination themed bridal shower, as your place cards are accented by their own little silver seashell! In sets of 6, these Silver Seashell Place Card Holders can work beautifully for events big and small! :Elegant seashell-shaped silver-finish metal place card holder Coordinating place card holders with aqua watercolor design includedPlace card holder measures 1.4" w x 1.3" h x 0.4" d; coordinating place card measures 2.3"w x 1.4" h Sold in sets of 6
Kate Aspen's Gold Pumpkin Place Card Holder leads your guests to their place at the table in a cute and seasonal way! Made from gold finished resin, these fall place card holders come with matching Kraft and gold foil place cards, creating the ultimate matching package to sit on your tables. Perfect for fall weddings and Thanksgiving celebrations, our Gold Pumpkin Place Card Holder is sure to make a gorgeous autumn impression! : Set of six gold resin pumpkin-shaped place card holders with coordinating place cards Coordinating Kraft place cards feature a gold foil border Place card holder measures 1.15" h x 1.38" in diameter, place card measures 2.36" w x 1.38" h Sold in sets of 6
In a set of 6, Kate Aspen's XOXO Gold Place Card Holder shares love with your guests the moment they walk in the door! These place card holders display your wedding or event place cards using a metal holder on a gold resin XOXO base, showing guests where to go simply and easily. Matching white and gold cardstock place cards are included with each set of holders. :Gold XOXO base place card holder with swirly stand holding included white and gold foil cards.Measures approximately 1.53"w x 1.57"h x 0.55"d, place card measures 2.16"w x 1.18"h x 0.03"dSold in sets of 6 with matching place cards included.
Whether your Hawaiian inspired wedding takes place on the Big Island, or you're just evoking a tropical feel for your bridal shower or luau party, chances are you'll need something to make place settings extra special. Kate Aspen's Gold Pineapple Place Card Holders are just the thing! Use them to seat guests, display photos, or label foods on the buffet table. :Gold, pineapple-shaped place card holder is made of resin and comes with coordinating watercolor striped place cards Pineapple place card holder measures to 1.4†w x 0.4â€d x 1.9â€h ; coordinating place card measures 2.2" w x 1.2" h Sold in sets of 6
Your day is all about love, so why not set the stage for your guests right away? Our LOVE Gold Place Card Holders display guest names in a way made to catch the eye. Sold in sets of 6, these beautiful gold LOVE themed table decor pieces will bring a little something special to any sized wedding! :Gold finish resin LOVE themed place card holderClassic "LOVE" letter design features a heart in place of the "O"Coordinating place cards included Place card holder measures 1"w x 3.3"h x 0.4"d; place card measures 2.5" w x 1.5" hSold in sets of 6
When your guests walk into your event, what are they going to look for first? The place cards! With Kate Aspen's Vintage Cameo Place Card Holders, your garden themed wedding or garden party bridal shower can have a little extra touch of elegance as each place card is settled in its own vintage-inspired cameo themed holder. Made from resin and including a floral cardstock place card, these vintage favor pieces will serve as a brilliant touch further accenting your theme! :Vintage inspired resin cameo place card holders in antique silver, and soft pink or mint green finishMeasures 1.8"h x 1.6"w x 0.6"d; coordinating place card measures 1.6" h x 2.8" wSold in set of 6
When the sea beckons, love sets sail near the splendor of a sun-drenched shore. Create the ambiance only a beach wedding can inspire by making your tables an ocean full of glistening silver sailboats with these "Shining Sails†Place Card Holders—each one a paragon of stunning simplicity. :Silvery metal sailboats hold place cards or photosSailboats measure 1 1/2" x 1 1/4" x 1/2"Sold as a set of four
You've found your happiness, now help your guests find their seats! Kate Aspen's "Double Happiness" Place Card Holders are adorned with the ancient Chinese symbol for double happiness, and are gilded with a gold finish for an elegant place card holder that will brighten up guest tables at your wedding. Even better, guests can take these keepsakes home to use for their own cards and photos. :"Double Happiness" Place Card Holder features an ancient Chinese double happiness symbol and is made of metal with a gold finish. . Place-card Included.Metal place card measures 1" w x 1.5" hSold in set of 6
How lucky your friends and family will feel when they see Kate Aspen's Lucky Golden Elephant Place Card Holders at your beautiful jewel tone wedding or Indian bridal shower! Just imagine how lovely these golden place card holders will look on your guest tables. Even better, your loved ones can take these elephant wedding favors home to serve as a keepsake memento of your special day. :Antique gold resin finish with embossed decorative detailMeasures 1.75" w x 1.25"h (at highest point)Sold in set of 6Comes with coordinating cards
Show your guests to their seat with style using Kate Aspen's Pink and Gold Heart Place Card Holders! When guests walk into your wedding or shower venue, the place card table is usually where they'll go first, and our heart-shaped place card holders from the Sweet Heart collection will lead them to their seats while communicating an atmosphere of love and your theme. In sets of 6, these work beautifully for weddings of all sizes! : Heart-shaped resin place card holders in three designs: pink and white stripes, pink with white polka dots, and pink with gold glitter. Coordinating place cards with pink heart design includedPlace card holders measure 2.3"w x 2.1"h x 0.8"d; place cards measure 2.3"w x 2.4"hSold in sets of 6
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text: This category lists images featuring Piko Pau 'iole Disclaimer Promotional ImagesEdit Add a photo to this galleryGalleryEdit Retrieved from "http://hawaiifiveo.wikia.com/wiki/Piko_Pau_%27iole/Gallery?oldid=21791" Ad blocker interference detected! Wikia is a free-to-use site that makes money from advertising. We have a modified experience for viewers using ad blockers Wikia is not accessible if you've made further modifications. Remove the custom ad blocker rule(s) and the page will load as expected. Categories: Gallery Episode Gallery Add category Cancel Save


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CCTV of a "nasty" moped robbery outside a Hindu temple that involved a victim being dragged to the ground has been released by police.
At about 4.40pm on Tuesday, June 20, a 52-year-old woman was standing outside the Hindu temple on Clarenden Rise, when she was approached by a suspect wearing a crash helmet.
The suspect grabbed her gold necklace and tried to remove it from her neck. The victim resisted and was dragged to the floor before the necklace broke free.
The necklace is valued at £600.
The suspect then got onto the back of one of two mopeds at the scene before they drove off with the assailant as a pillion passenger.
Detective Constable Alexander Hamilton, from Lewisham CID, said: "We are urgently seeking any information regarding this nasty crime, which has left the victim shaken from her ordeal. Please come forward if you know anything, witnessed anything, or you know who the men in the CCTV images are."
Three suspects are all described as wearing a black bike helmet.
the first suspect was wearing a white shirt, a dark blue jacket with grey trousers and black shoes.
The second suspect was wearing blue shoes and a grey tracksuit with white stripes.
The third suspect was wearing a grey hooded top, dark trousers and white trainers.
Anyone with information can call Lewisham CID via 101. To give information anonymously contact Crimestoppers on 0800 555 111 or visit crimestoppers-uk.org.


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"We have had Eugene look after our cat twice now and he is great, he really went above and beyond..."
"Cass was great, our Boston was very well looked after. He was walked everyday and just knowing he..."
"My mini dachies Lola and Violet had a fantastic 4 night stay with Christina and her family, it was..."
"5 stars! Emma is extremely lovely and looked after our cat really well. We were very happy with..."
"Gabrielle, thanks so much for looking after Zoe, she had a lovely time and was very spoilt."
"Booked again through Martina - she was great. She makes it very easy for us to go away knowing our..."
"Wonderful care of Bobby. He is always so happy to stay at Lisa's! "
"She was very good, communicating well and quickly"
"Felt very relaxed about leaving Mishka in the care of Linda. She asked appropriate questions and..."
"Awesome. Gussy was extremely well looked after. Thank you so much Steve and Freevia"
"Sally is wonderful. She was so caring to our pups. Couldn't ask for more. Thank you Sally"
"Thank you sooo very very much! She did such a Fantastic job of looking after pur fur babies and..."
"Thanks Sharron"
"Awesome as always. Great to know our boys are safe in 'Nanny Isobel's' care when we travel... ?"
"Amazing service!"
"Laura was great and very accomodating. Am recommending her and will love to have her sit again "
"Thanks again"
"Lorna was well organised, sent photos, and our dog Basil looked very happy upon return, great job..."
"Awesome "


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Hair Care« Previous EntriesNext Entries »
Thinning Hair: How to Care for It in 5 (and a Half) Easy Steps
THERE are probably as many causes for thinning hair as there are people on the planet. But the most common are sickness, poor nutrition, medication, over-processing and genes. While you are taking care of any issues you do have control over, you can follow these tips to care for the hair you've got.
No More 'Poo? Never Wash Your Hair Again!
Here's a secret shampoo makers don't want you to know: you can have clean, lustrous and healthy hair without their products. That's right, whether you're spending a buck for a cheapy bottle at the drugstore or shelling out $20 or more on high-priced salon stuff, you can save your money thanks to one of your […]
Natural Hair Loss Treatment
Poor nutrition and deficiencies in some vitamins and minerals may be contributing to your losing your hair. In this article you will learn about natural hair loss treatments you can start using today to curb your follicular fall out.« Previous EntriesNext Entries »


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This property has been removed by the agent. It may be sold or temporarily removed from the market
Commercial Property for salePark Street, Wallasey, CH44
Offers in Region of £130,000
Property Description
Key features
- Fabulous Office Space with Yard Area
- Close Proximity to Liscard Town Centre
- Bright and Airy Office Space with Ajoining Storage Area
- Yard Area with additional Workshop
- Viewing Highly Recommended
Full description
The Property Centre are delighted to offer for sale this commercial yard space complete with office area, in an excellent location and in close proximity to Liscard town centre.
Currently trading at D & R Services, the yard area is gated with an additional enclosed workshop inside.
The bright and airy office space is complete with kitchen, WC and storage cupboard. Adjoining the office space is a further large storage area with overhead storage extending back over the office space ceiling.
The office and large storage area are also complete with metal shutter and car parking area.
A fabulous opportunity not to be missed!
Office Space : 15'4" x 14'11" (4.67m x 4.55m) , Bright and Airy Office Space with UPVC front door and windows, laminate flooring, Kitchen 5ft 6in x 4ft 6in (1.68m x 1.37m), WC and Storage cupboard complete with built in shelving.
The office has telephone, fax and internet points, underfloor heating and a fire escape to the front of the office.
Storage Area (adjoining the office) : 17'11" x 16'5" (5.46m x 5.00m) , Storage area currently containing shelving ,which can be removed, overhead storage which extends to the length of the office ceiling.
Yard Space : 45'7" x 11'1" (13.89m x 3.38m) , Gated yard space.
Measurements up to the wall of the Workshop.
Workshop : 24'4" x 15'9" (7.42m x 4.80m) , Brick built Workshop space inside gated yard area, also with own door access.
Outside : To the front of the premises is a car parking area with an outside tradesman's WC. The Office and adjoining Storage area has a metal shutter.
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Disclaimer - Property reference PRPCE_000323. The information displayed about this property comprises a property advertisement. Rightmove.co.uk makes no warranty as to the accuracy or completeness of the advertisement or any linked or associated information, and Rightmove has no control over the content. This property advertisement does not constitute property particulars. The information is provided and maintained by The Property Centre, Wallasey. Please contact the selling agent or developer directly to obtain any information which may be available under the terms of The Energy Performance of Buildings (Certificates and Inspections) (England and Wales) Regulations 2007 or the Home Report if in relation to a residential property in Scotland.
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text: Simon Hoellerbauer is a research intern at the Project on Democratic Transitions. He is a recent graduate of Kenyon College with a BA in Political Science and Modern Languages (Spanish and Russian). His research interests include democratic transitions, especially in Latin America and in the former Soviet Bloc, and the role democracy plays in how countries carry out their foreign policy.


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SAN FRANCISCO (MarketWatch) -- Data Domain Inc. shareholders were probably not surprised that their board of directors rejected the latest offer from EMC Corp., the Goliath storage company in the ongoing bidding war between it and the smaller Network Appliance Inc.
Data Domain DDUP said Monday that its board recommended against EMC's EMC, -0.55% $30 all-cash offer -- or about $1.8 billion -- for the data backup software company. One reason for the rejection of the larger, cash-rich EMC is a termination agreement between Data Domain and NetApp NTAP, -0.53% which would force Data Domain to pay a $57 million termination fee. Data Domain also cited the "conditional nature" of EMC's offer. See news story here.
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EMC already came out swinging with a statement shortly after the Data Domain rejection, saying it does not believe Data Domain shareholders will approve the deal with NetApp. EMC said its all-cash offer, versus NetApp's cash-and-stock deal, is superior and gives Data Domain "price certainty and price protection."
A termination pact of $57 million is a small price to pay when one is talking about a deal that would surpass $2 billion, if EMC raises its all-cash offer. Data Domain's board is likely putting on a good bluff in this high-stakes game.
-- Therese Poletti


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Solve This (? + ? + ?=30)
If 1111=R, 2222=T, 3333=E, 4444=N Then 5555=?
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Dynamic susceptibility contrast (DSC) and arterial spin labeling (ASL) are both used to measure cerebral blood flow (CBF), but neither technique is ideal. Absolute DSC-CBF quantitation is challenging due to many uncertainties, including partial-volume errors and nonlinear contrast relaxivity. ASL can measure quantitative CBF in regions with rapidly arriving flow, but CBF is underestimated in regions with delayed arrival. To address both problems, we have derived a patient-specific correction factor, the ratio of ASL- and DSC-CBF, calculated only in short-arrival-time regions (as determined by the DSC-based normalized bolus arrival time [Tmax]). We have compared the combined CBF method to gold-standard xenon CT in 20 patients with cerebrovascular disease, using a range of Tmax threshold levels. Combined ASL and DSC CBF demonstrated quantitative accuracy as good as the ASL technique but with improved correlation in voxels with long Tmax. The ratio of MRI-based CBF to xenon CT CBF (coefficient of variation) was 90 ± 30% (33%) for combined ASL and DSC CBF, 43 ± 21% (47%) for DSC, and 91 ± 31% (34%) for ASL (Tmax threshold 3 sec). These findings suggest that combining ASL and DSC perfusion measurements improves quantitative CBF measurements in patients with cerebrovascular disease.
Bolus dynamic susceptibility contrast (DSC) perfusion-weighted imaging (PWI) and arterial spin labeling (ASL) are two methods of measuring cerebral blood flow (CBF) using MRI, each with different strengths and weaknesses (1–3). ASL CBF levels are reliable in regions with rapidly arriving flow but suffer from reduced signal-to-noise ratio (SNR), CBF underestimation, and artifacts in regions with long arterial arrival times (4–7). In theory, DSC-based CBF measurements are unaffected by long arrival times if Fourier-based or delay-invariant block-circulant singular value decomposition deconvolution methods are used (8–10). However, absolute quantitation is challenging for many reasons, including uncertainties regarding the arterial input function (AIF) partial-volume amount, the effect of vessel orientation on contrast relaxivity, the nonlinear relationship between transverse relaxivity and contrast concentration, clipping of AIF signal due to high tracer concentrations, and susceptibility-based voxel shifting (11–15). For these reasons, both techniques have yet to be fully embraced by the neuroimaging community for evaluating patients with cerebrovascular disease.
This study describes a calibration method that uses ASL CBF measurements in regions with short transit delays (as measured by the AIF-normalized time to peak of the residue function [Tmax]) to provide a patient-specific correction factor (CF) for DSC CBF measurements. We have termed this method "combined ASL and DSC CBF," or CAD-CBF. We hypothesize that in patients with cerebrovascular disease, the CAD-CBF method will have less bias and more precision with respect to a gold-standard CBF method. We also hypothesize that application of such a CF will improve CBF measurements in long arterial arrival time regions compared with ASL. To test this, we have evaluated 20 patients with known cerebrovascular disease who received xenon CT (xeCT) and MR perfusion imaging. xeCT is a gold-standard perfusion measurement that uses a diffusible tracer (xenon gas) that is inhaled by the patient and that permits CBF measurement using the autoradiographic ("Kety-Schmidt") method (16,17).
The study was approved by the institutional review board and was Health Insurance Portability and Accountability Act (HIPAA) compliant. Patients were enrolled if they had symptoms concerning for cerebral ischemia (acute, subacute, or chronic) or transient ischemic attack and were willing to undergo the xeCT CBF study. To be included in the study, the stable xeCT and MRI studies had to occur within a 48-h period.
Twenty patients met the inclusion criteria (11 men, nine women; mean age 53 years; range 25–74 years). Their clinical indications were as follows: 13 moyamoya disease, four acute ischemic stroke, three transient ischemic attacks; of these, five had unilateral internal carotid occlusion, while two had bilateral internal carotid artery occlusion. The root-mean-squared time difference between the xeCT and MRI studies was 27 h. In 11 of 20 patients (55%), xeCT was acquired before MRI.
CT was performed using a GE LightSpeed 8 detector scanner (GE Healthcare, Waukesha, WI) integrated with a stable xenon enhancer system (Diversified Diagnostic Products, Inc., Houston, TX). The xeCT protocol interrogated four contiguous slices (axial mode, slice thickness 10mm, field of view 25 cm, 80 kVp, 240 mA), beginning at the level of the basal ganglia, aligned with the superior orbitomeatal axis. Eight sets of images were acquired at 45-sec intervals, and the total time for the xeCT examination was 6 min. The first two time points were acquired while the patient breathed room air, and the remaining six time points were acquired with the patient breathing 28% xenon (Xe) gas, 20% oxygen, remainder air through a snug facemask. An end-tidal gas analyzer recorded expired Xe concentration, which was associated with the alveolar Xe concentration. The alveolar Xe concentration was assumed to correspond to the arterial Xe concentration, a reasonable approximation, except in patients with severe respiratory disease and abnormal alveolar-to-arterial gradient. CBF was calculated using the Kety-Schmidt method by the manufacturer's dedicated commercial software (Diversified Diagnostic Products, Inc.) according to Johnson et al. (18). The output was CBF maps with in-plane spatial resolution on the order of 2–3mm.
All MRI scans were performed at 1.5 T (Signa LX/i; GE Medical Systems, Waukesha, WI). Anatomic imaging was performed in addition to the perfusion measurements and always included fluid-attenuated inversion recovery and diffusion-weighted imaging, with a b value of 1000 sec/mm2.
DSC was performed using gradient-echo echo planar imaging during passage of 0.1 mmol/kg of either gadopentetate dimeglumine (Magnevist; Berlex Laboratories, Wayne, NJ) or gadodiamide (Omniscan; GE Healthcare), delivered using a power injector at 4 mL/sec. Image readout was performed using a multishot, multiecho Generalized Autocalibrating Partially Parallel Acquisitions (GRAPPA) echo planar imaging sequence with an acceleration factor of 3 and pulse repetition time/echo time of 1225/(17,30,52) ms (19). Twelve to 15 axial slices of 5mm thickness separated by 1.5mm interslice gap covered the entire supratentorial brain. In-plane resolution was 2.6mm (matrix 96 × 96, field of view 240mm). The DSC images required 2 min to acquire. Again, the slices were aligned with the superior orbitomeatal axis.
AIF and venous output function detection and deconvolution with block-circulant singular value decomposition (10) were performed, using a regularization threshold of 15% of the maximum singular value, in line with the work of Wu et al. (10), to create maps of CBF, cerebral blood volume (CBV), mean transit time, and AIF-corrected time-to-peak of the residue function (Tmax). To avoid subjective selection of AIF and venous output function, we employed automatic selection of 10 voxels each, based on location, peak value, peak width, and contrast arrival time (20). This algorithm resulted in AIF locations in middle cerebral arteries, anterior cerebral arteries, basilar artery, or internal carotid arteries. The venous output function locations were typically in the superior sagittal sinus, transverse sinus, or straight sinus.
Transverse relaxivity change (ΔR2*) was calculated using a weighted least-squares fit of the signal intensity from the three acquired echoes (15). A nonlinear relationship between blood tracer concentration and transverse relaxivity was assumed for tissue, according to theoretical and experimental work (14,21,22). For the tissue signal, a linear relationship between the change in transverse relaxation rate, ΔR2*, and gadolinium concentration, c(t), was used:
where a relaxivity of r2 = 0.044 (ms mM)−1 was assumed for gadolinium at 1.5 T. For the AIF, a quadratic relationship between relaxivity and concentration was used (21):
where a = 7.6 × 10−3 (ms mM)−1 and b = 574 × 10−6 (ms mM2)−1 for 1.5 T gradient-echo. All subsequent calculations were performed with the data expressed in these units of tracer concentration.
Pulsed continuous ASL was performed using a labeling period (TL) of 1500 ms, followed by a 2000-ms post-label delay (w) (23). Readout was accomplished with a three-dimensional background suppressed fast-spin-echo stack-of-spirals method. Multiarm spiral imaging was used, with eight arms and 512 data points acquired on each arm (bandwidth ± 62.5 kHz), yielding in-plane spatial resolution of 3mm. Forty 4mm-thick slices in the axial plane were acquired without intraslice gaps. Because the spirals are interleaved, both echo time (2.5 ms) and total readout time (4 ms) could be kept quite short, resulting in excellent performance in high-susceptibility regions. Pulse repetition time was approximately 5.5 sec. A high level of background suppression was achieved by the use of four separate inversion pulses placed after the labeling pulse during the postlabel delay period (at 1.49 sec, 0.68 sec, 0.25 sec, and 0.06 sec before readout). The sequence required 6 min to acquire, which included proton density images required for CBF quantitation. Postprocessing was performed using an automated reconstruction script that returned CBF images directly to the scanner console within 1 min. CBF (in milliliters/100 g/minute) was calculated in each voxel using the following equation:
where λ is the brain:blood partition coefficient (0.9 mL/g), w is the postlabel delay (2.0 sec), T1blood is the T1 of arterial blood at 1.5 T (1.4 sec), α is the labeling efficiency (0.85), TL is the labeling duration (1.5 sec), ΔS is the ASL difference signal (i.e., label-control image), and S0 is the proton density signal intensity. The term (1 − exp(−2.0s/1.2s)) in the numerator reflects the presence of a saturation pulse that is applied in the proton-density images and allows conversion between measured MR signal (S0) and the unperturbed longitudinal gray matter magnetization.
To determine an ASL-based global CF, we determined the location of all voxels with relatively rapid arterial arrival time, as measured by the DSC Tmax maps. Multiple different Tmax thresholds (Tmaxthresh) were examined, ranging from <1.5 sec to <6 sec at 0.5-sec intervals, as well as an infinite Tmax (i.e., all voxels were used for determining the CF). We found that shorter Tmaxthresh (i.e., less than 1.5 sec) did not reliably include voxels in all patients for the subsequent calculations. While in practice it is reasonable to choose only voxels with the shortest Tmax, we examined these other conditions to evaluate the sensitivity to Tmax threshold choice and any potential tradeoffs. After three-dimensional rigid-body registration of ASL and DSC, the mean CBF calculated from only the voxels that met the Tmax criteria were calculated for both the ASL and DSC, yielding a patient-specific CF:
This dimensionless scaling factor was then multiplied with the DSC CBF map to determine the "corrected" hybrid ASL-DSC CBF, which we term CBFCAD:
Figure 1 is a schematic of the steps taken during this process.
Finally, we chose to examine the performance of this method against another proposed method for converting DSC CBF maps from relative to absolute units in the literature (12,24), that of assigning an ROI of normal appearing white matter to 22 mL/100 g/min. ROIs comprising 180 voxels (1.8 mL) were manually positioned in the white matter on the superiormost slice corresponding to the centrum semiovale. DSC CBF maps were then scaled such that this ROI measured 22 mL/100 g/min. Results are presenting in Table 1.
Rigid-body rotation based on mutual information using SPM5 (Wellcome Department of Imaging Neuroscience, University College of London, London, England) was used to coregister the MR and xeCT images. Typically, fluid-attenuated inversion recovery anatomic images were coregistered to the four contiguous xeCT slices, and this transformation was then applied to the DSC and ASL CBF maps. Each slice was then divided into 1-mL cubic ROIs, using a "battleship grid" consisting of contiguous square ROIs. This yielded a large number of voxels with equal spatial resolution (about 400 voxels per patient) that were free of any possible region-of-interest (ROI) selection bias. Voxels belonging to the ventricles and cortical sulcal CSF were excluded by thresholding the diffusion-weighted images manually. In each patient, scatterplots of the individual DSC and ASL CBF maps with xeCT were created, yielding slope, intercept, and correlation coefficient (R).
The global mean CBF was calculated by averaging the (~400) individual ROI measurements described above in each patient. The MRI-based CBF measurements were normalized by the xeCT CBF value using the CBF ratio:
where all values are global means. Ideally, this value should be 1, which would represent exact correspondence (i.e., no bias) between the two techniques. To determine the precision of the CBF between patients, the coefficient of variation (COV), or normalized between-patients standard deviation, was used:
where the overbar represents the mean of all n patients and SD is standard deviation. Lower COV represents a more precise measurement. A COV of 0% means that each MRI-based CBF measurement corresponds to the xeCT CBF measurements to the level of a patient-independent scaling factor.
CBV was also calculated from the DSC maps before correction, using the ratio of the integrated tissue and venous output function concentration-time curve; postcorrection CBV maps were created by multiplying the precorrection DSC images by the same CF described above.
Linear regression was performed comparing the mean xeCT-based and MRI-based CBF measurements between patients.All postprocessingwas performed usingMatlab 7.3 (MathWorks Inc., Natick, MA). Stata, release 9.2 (StataCorp LLP, College Station, TX), was used for all statistical calculations. All values are reported as mean ± standard deviation. P < 0.05 was considered significant.
Figure 2 demonstrates a typical coregistered data set, including xeCT CBF, as well as the three different MRI-based approaches (DSC alone, ASL alone, and combined) in a patient with acute ischemic stroke. It can be seen that the ASL demonstrates a region of both high and low CBF in the right middle cerebral artery territory, which is not present on either the DSC or xeCT CBF maps. However, the uncorrected DSC CBF map markedly underestimates true CBF, as measured by xeCT. The CBFCAD image demonstrates both improved representation of the right MCA region and improved quantitative CBF levels.
Figure 3 demonstrates the effect of varying Tmaxthresh. In short, we found that the precise threshold was not critical: within the range from 2 to 6 sec, the mean CF ranged between 2.28 ± 1.32 and 2.53 ± 1.37. Without any thresholding based on the Tmax lesions (i.e., using all colocalized voxels in the ASL and DSC scans), CF was 2.48 ± 1.32. However, the CF in individual patients varied significantly, consistent with the idea that this is a patient-specific factor; for example, using a Tmax threshold of 3 sec, the range of the CF in the different patients ranged from a low of 1.02 to a high of 6.71.
As the threshold increases, more voxels are included in each patient for the calculation of CF (Fig. 3), with about 50% of voxels included for Tmax between 3 and 4 sec. Based on the improved precision and low bias, we believe that a Tmax of 3 sec represented the best operational choice for Tmaxthresh in this patient population. Table 1 presents the mean CBF data for xeCT, uncorrected DSC, ASL, and the combined method for a range of Tmaxthresh, including nonthresholded (i.e., Tmaxthresh = infinity). CBF measured using the CAD approach had a bias roughly equivalent to the ASL method, but the precision of the measurement, as reflected by the COV improved, decreasing to 33% from 47% for Tmaxthresh of 3 sec. Finally, the method in which a normal-appearing white matter ROI is set to 22 mL/100 g/min partially improves interpatient variability (COV 36%) but causes about 30% overestimation in mean CBF compared with the xenon CT gold standard (Table 1). As in the work of Mukherjee et al. (12), the reason for this is that the xenon CT CBF values in these ROIs had a wide range, from 6 mL/100 g/min to 35 mL/100 g/min. Figure 4 shows the mean CBF measurements for each MRI method compared with xeCT CBF.
In individual patients, both ASL and uncorrected DSC had similar correlation for all voxels (R = 0.34 ± 0.16 for ASL, R = 0.39 ± 0.13 for DSC). Multiplication of the DSC images by a global CF will not improve correlation of individual CBF ROI measurements in individual patients; however, when ROIs from all patients were combined, there was a significantly improved correlation of the CBFCAD maps (R = 0.32 for CAD-CBF, R = 0.30 for ASL, R = 0.26 for DSC; n = 6496 voxels, P < 0.05 for all values being different from each other). This effect was particularly evident when considering only voxels with long Tmax (one example is shown as Fig. 5, for Tmaxthresh of 3 sec, examining only voxels with Tmax >7.5 sec). In these regions, the correlation of combined maps is higher than that of the ASL CBF maps.
While we did not have a gold standard for evaluating CBV, we note that the CF above can be applied to these maps and can be compared with literature values. The mean CBV in the brain increased from 1.63 ± 0.79% (precorrection) to 3.50 ± 1.42% (postcorrection) for a Tmaxthresh of 3 sec.
ASL has been shown to accurately measure quantitative CBF in normal volunteers (25), but it has not been validated in a patient population with a wide variety of cerebrovascular disease and extensive collateral flow. In particular, CBF errors are known to occur in regions with prolonged arterial arrival times (4–6), which may lead to CBF under- or overestimation, depending on the precise relationship between arterial arrival time and the sequence's postlabel delay time, as well as whether vessel suppression techniques are used. This can lead to a confusing picture, and for this reason, many have doubted whether ASL could play a role in the diagnosis and management of patients with severe cerebrovascular disease, particularly acute stroke patients.
Some of these problems can be mitigated by the use of ASL sequences with multiple postlabel delay times (6,26,27). Improved estimation of CBF in the setting of variable delay can be accomplished by nonlinear fitting of the ASL difference signal data to a generalized kinetic model or by using a "model-free" approach, in which the difference between non-vessel-suppressed and vessel- suppressed images acts as an AIF. However, this method cannot be used for regions supplied by very slow collateral pathways, in which no ASL difference signal is observed even for the longest postlabel delays. Also, multiple postlabel delay ASL sequences necessarily have either reduced SNR for individual time points or an overall increase in scan time.
DSC CBF methods yield robust relative CBF maps, especially if delay-invariant deconvolution methods are performed (10). However, prior studies have shown that the intersubject variability with DSC CBF measurements is significant (11,12,28,29), which has been attributed to a host of factors, including AIF partial volume, vessel orientation sensitivity, AIF clipping due to signal saturation, nonlinear contrast relaxivity, susceptibility-induced voxel location shifting, and differences in large vessel/small vessel hematocrit, such that absolute CBF quantitation is challenging in individual patients. While degradation of the AIF shape and regularization will contribute to quantitation errors, we hypothesize that the major contribution to CBF quantitation errors emanates from scaling issues due to the aforementioned effects on the AIF.
Both DSC and ASL, when used in isolation, thus have difficulties measuring quantitative CBF in patients with cerebrovascular disease. However, the strength of each measurement can be leveraged using a combined ASL-DSC approach, we have termed CAD-CBF. ASL quantitation is robust in regions with normal arrival times; DSC can be used to identify precisely these voxels, using the timing information that can be obtained from Tmax maps. Thus, a patient-specific CF can be determined by equating the mean CBF obtained from each method only in voxels with Tmax below a prespecified threshold. It is important to note that the precise CF is dependent upon any corrections that have been applied to scale the DSC data (e.g., brain density factor, relaxivity and relaxation rate look-up table, and small/large vessel hematocrit (Hct) correction) and therefore would likely vary, depending on the exact implementation and postprocessing steps used calculate absolute CBF. The method is only predicated on the assumption that the relative CBF maps produced by DSC are accurate or, at minimum, are more accurate than ASL. The CF value is applied to the entire DSC CBF data set, taking advantage of the better relative CBF properties of DSC in regions with long delay times, where ASL suffers from T1-based label decay and arterial transit artifacts (e.g., incomplete arterial bolus arrival to the capillaries).
This general approach is flexible, and a similar CF can also be derived from and applied to spin-echo DSC sequences. In fact, this may be preferable, given that gradient- echo echo planar imaging is sensitive to large blood vessels (which should not be included in the perfusion measurement as this would, in theory, lead to a "flow-through artifact") (30). ASL and spin-echo-DSC also share the characteristic of being most sensitive to perfusion at the microvascular level (31,32). This may explain the remaining small underestimation of CBF by about 10% in the combined CBF maps. The use of a patient-specific CF also obviates the need for determining the magnitude of the AIF, which is fundamentally problematic for spin-echo acquisitions. This, in turn, would enable truly quantitative measurements of both microvascular CBF and CBV (11).
We found that the specific choice of Tmaxthresh was not critical. This may seem nonintuitive, but we believe is due to the relatively small number of voxels with long Tmax in most patients with cerebrovascular disease. Thus, we found that good results were achieved even without using a threshold (i.e., determining the CF based on all the voxels within the colocalized DSC and ASL volumes); such an approach might be feasible in most patients and could reduce computational time and errors from noise in the Tmax maps. However, we believe the current approach is most prudent, given that the CF is likely to be sensitive to Tmaxthresh for patients with large and/or bilateral lesions, such as those seen in moyamoya disease or carotid terminus occlusions. We believe that the optimal level for Tmaxthresh is around 3 sec as this resulted in the lowest intersubject variability, accompanied by reasonably low bias compared with gold standard xeCT CBF. Also, at this threshold, 41.1 ± 14.3% of voxels are used in the calculation, thus minimizing issues with noise that could occur with shorter Tmaxthresh.
The combined ASL-DSC method yields a better estimate of gold-standard CBF compared with either ASL or DSC used alone. Specifically, the CAD-CBF method has a bias and precision equal to or better than that for ASL, with improved correlation in voxels with long Tmax. The correlation of all voxels in all patients was also significantly increased using the combined method, though the overall difference was slight and may not be clinically relevant. However, this improvement was more pronounced in voxels with long Tmax (see Fig. 5), as expected, given the challenges of ASL imaging in such regions. Finally, while we could not compare the corrected CBV values with a gold standard, the use of the CF did increase the mean whole-brain CBV (3.5 ± 1.4%) to the level of literature values (3.8 ± 0.7%), as measured by C15O Positron Emission Tomography (PET) (33).
The method does require that two perfusion studies be obtained, adding either 2 or 6 min to the protocol, depending on which sequence one considers to have added. The ASL sequence used in the current study obtains three number of averages (NEX) to increase SNR. This was done because we ask our clinicians to examine both ASL and DSC hemodynamic studies, and only one average for the ASL study results in poor image quality. However, for the purposes of measuring the CF, it is likely that fewer NEX are required since the CF is derived from mean values calculated in a large ROI (usually about half of the total imaged volume); this would lead to a reduction in imaging time and could be incorporated into a "prescan" module of the DSC measurement. For the same reason, larger voxels can be used. The added SNR affords the use of parallel imaging, which would further reduce scan time. It should be noted that differences in geometric distortion between the ASL and the DSC acquisitions could lead to imperfect registration on a voxel-by-voxel basis and could conceivably affect the CF calculation. In our implementation, the ASL is a three-dimensional spin echo sequence, while the DSC is a two-dimensional gradient echo echo planar imaging sequence. However, we believe the effects of this are relatively small, given the large number of voxels used for the CF calculation, most of which are not located in problematic regions such as the inferior frontal and temporal lobes. It may be desirable for this reason to acquire both the ASL prescan and the DSC images using a readout with similar geometric distortion profiles.
Several previous reports have described approaches to normalize CBF measurements in individual patients, using a patient-specific CF. Lin et al. (28) described a method that derived a CF normalizing the area under the curve of the individual patient's superior sagittal sinus, with the mean value derived from a small cohort of young normal volunteers. A similar method is also used in computed tomography perfusion (CTP). This method is predicated on the idea that (1) the measurement is accurate in normal volunteers and (2) the percentage of the cardiac output delivered to the brain is a constant, regardless of age or disease state. Using this method, they showed good correlation between CBF measured with DSC and PET in five different patients with unilateral carotid occlusion. They did not report on whether the accuracy was equivalent between the affected and unaffected hemispheres, which would be expected to have markedly different transit delay times. Mukherjee et al. (12) examined a similar group of seven patients with chronic unilateral internal carotid artery occlusion. They found that the scaling the individual measurements such that a deep white matter ROI was fixed to be 22 mL/100 g/min, a value derived from PET studies, did not significantly improve the correlation of DSC and gold-standard PET CBF measurements (data not reported). We found that the use of this method was associated with partial improvement in interpatient variability, but, like Mukherjee et al. (12), that the absolute CBF values were overestimated. In addition, this method is quite subjective and time consuming compared with the CAD-CBF approach.
Sakaie et al. (29) proposed a novel "bookend" method, in which steady-state CBV measurements obtained using T1-weighted images before and after bolus contrast passage could be used to determine a patient-specific CF, with the assumption that there is slow exchange between intra- and extravascular water on the time scale of the measurement. They demonstrated that the use of this CF led to a reduction in the variability of CBF measurements between different normal young volunteers and that the CBF levels were more compatible with literature values, though they did not perform direct comparison with a gold-standard method. The method has the advantage of being self-calibrated, in that neither a separate gold-standard measurement nor a population-averaged mean value is required. It does require two additional sequences obtained before and after the bolus perfusion study, which added 4 min to their protocol.
The current study is limited by several factors. First, the number of patients was relatively small. It is possible that there are CBF errors even in the ASL-derived maps in regions with short Tmax or that the specific model used to convert ASL difference signal and proton-density images into CBF values is not valid. There could be leakage of contrast on DSC images that is spatially variable, leading to errors in the final CAD-CBF maps. Also, the block-circulant singular value decomposition method used for calculation of CBF and Tmax on the DSC maps, while accounting in theory for delay, does not address relative CBF errors related to bolus dispersion or inaccurate representation of AIF shape due to clipping or partial- volume artifact.
The calculation of the CF requires that the relative CBF be comparable between the two techniques, and it should be remembered that ASL uses a diffusible tracer to measure CBF, while DSC (whether gradient echo or spin echo) is based on a nondiffusible tracer. In particular, gradientecho echo planar imaging maps that included large vessels (i.e., partial-volume contribution from arterioles and venules) could lead to systemic underestimation of the CF since the vessels tend to have short Tmax, and this may explain the persistent slight underestimation in the CAD-CBF maps compared with xeCT. Also, we chose to determine a CF based only on Tmax; one could conceive of other approaches to select the appropriate voxels, including criteria based on tissue type (gray versus white matter), baseline CBF levels, or even presence or absence of pathology. We emphasize that this is a first-level approach that is relatively easy to implement, and it is possible that other metrics could be applied that may further improve the accuracy of the technique.
Finally, the data analysis assumes that the CBF for both the MRI and xeCT sessions was equal; systemic CBF differences could occur between the examinations, and scans were not performed at the same time of day or under the same diet or CO2 conditions. It is possible that much of the remaining variability in the measurement is due to these factors. Also, there is some evidence that the inhalation of xenon-enriched gas can lead to small (5%) CBF increases (16).
We have demonstrated a method that we have termed CAD-CBF, based on combined DSC and ASL imaging methods, which has reduced bias and precision when compared to gold-standard xeCT CBF. A patient-specific scaling factor is derived from equating the CBF levels on the ASL and DSC images only in regions with short arterial arrival times. Correlation between CAD-CBF method and xeCT CBF is improved, particularly in regions with long arterial arrival times. We believe the approach supports the use of both ASL and DSC in patients with cerebrovascular disease. For scaling purposes, we anticipate that an ASL scan with a coarser resolution than used in this study would be sufficient. Thus, a much more time-efficient ASL method could be used that would minimize the additional time needed for this calibration measurement.
The study was partially supported by the Neuroradiology Education and Research Foundation Scholar Award (G.Z.) and the Lucas Foundation.
Grant sponsor: NIH; Grant number: R01-NS066506.
Additional Supporting Information may be found in the online version of this article.
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


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Tax time can be a stressful part of the year for anyone, but seniors may be feeling the pressure more than others. Constant changes to the U.S. tax code, keeping on top of exemptions and credits, and the changes to both Medicare and the health care industry in general on the heels of the Patient Protection and Affordable Care Act can leave older adults struggling to keep their heads above water.
Fortunately, though it may seem daunting, filing taxes doesn't have to be a major event. Here are a few things to keep in mind to help seniors make it through …read more


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No! Don't.
Don't make an Art Lover fall for you.
They are the most dangerous set of beings ever. Selfish and little crybabies. They will use you for their art.
They will make sketches out of the way you make them feel.
They will write about you.
They will compose for you.
They will play music out of the feelings you make them feel.
You will become a work of them. A muse. Silently using you, your memories for their works.
You think hurting, leaving and backstabbing them will teach them a lesson? Haha, no dude. Hurting them will make them more powerful. They will use this hurt as a weapon – they will use this hurt as a canon to fire shots at you – in the form of paintings, photographs, write-ups, poems and stories.
Everyone will empathise with them, making you the villain. Haha!
Piece of advice, dearie? Make them love you only if you are prepared.
How and why?
They are the dreamers. They do not tolerate reality. They build their own sense of reality. They exist in this world and live in their own world. Their love is deep like the oceans, fresh like the mountains. They are suckers for consummating love. Fictions and fantasies are their drugs. They dream all day and night coordinating with their own thoughts. Music for them is equivalent to food and water, it gets counted in the basic survival list. They are hyperactive. They are the deep talkers and listeners. They are the restless ones, the silent yet angry ones, the impatient yet patient ones. They are the living contradictions.
Treat them right, and they will make you their king. Treat them wrong, they will make you their pawn instead. Haha. Both ways, there is no bringing them down.
Who doesn't want to feel loved like in the movies with those happy endings?
Love an artist right, I tell you.
They will make you their inspiration and create things which will make your eyes pop and jaws drop. Believe me!
You will be the hero of their stories.
The lyrics to their songs.
The candid images to their surreal photoshoots.
The feelings to their poems.
The imagination to their paintings.
The heartfelt notes to their musical instruments.
The content of their blog posts.
They will be the reason for your ecstasy.
Hurt them and I promise, you will break, for the art they create out of the hurt will remain… Forever.
Their agonized fire will burn you to ashes.


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Sleeper Sofa Chaise
Sleeper Sofa Chaise, picture size x posted by admin at May 29, 2016
Sleeper Sofa Chaise
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Links to Learning is a program funded by the NSW Government and administered by the NSW Department of Education. Under the 2017 – 2019 Links to Learning Community Grants Program, Pathfinders has been approved to deliver targeted programs to students in Year 6 through Year 11 who are at risk of disengaging from learning in the Barwon and the Northern Tablelands school districts.
Projects have been developed in line with Program Guidelines and in collaboration with local schools.
The Program emphasises the importance of completing schooling to achieve future hopes and aspirations and will reach disengaged students via a range of hands-on evidence-informed activities focused around mediums with strong appeal such as drumming, music, art and the outdoors. Delivered in a highly interactive and powerful way, the intent is that participants develop life-changing thinking that will positively impact on future behaviour and decisions.
Pathfinders therapeutic approach to youth development within the RAP philosophy Circle of Courage, which looks at youth development and welfare through the four elements – Belonging, Mastery, Independence and Generosity was used as inspiration during the project's development.
Objectives of the Links to Learning Community Grants Program
Key objectives of the Links to Learning Community Grants Program include:
Listen Community involvement and support along with interagency collaboration is an important part of the Pathfinders culture. We enjoy all opportunities to get to know and work alongside our partners! It was a very busy weekend for Pathfinders with our not-for-profit being represented at two local community events. Friday night saw us up against some... View Article
Listen Pathfinders has been named a Finalist in the Armidale Regional Business Awards 2017. This year, the Awards attracted around 80 top-notch entries showcasing the great amount of local businesses who are investing a lot of energy and insight into the strategies that are achieving their business success. Proudly, Pathfinders is one of these businesses.... View Article
Listen From inland to the coast, wherever you looked you would've found our program staff and kids celebrating NAIDOC Week. On July 6th, our Family Referral Service Mid North Coast team celebrated NAIDOC Week at the Port Macquarie Family Fun Day, featuring dancing, music, language circles and more. Our FRS MNC team attended with badges,... View Article
Listen NAIDOC Week might've passed this year, but many of our programs, staff and kids are still reminiscing on how great it was to celebrate Aboriginal and Torres Strait Islander history, culture and achievements throughout the region. Our Family Referral Service (FRS) team in Tamworth also attended the Family Fun Day on Friday at Bicentennial... View Article
Listen Our Ability Links Linker, Bec Browning, attended the NAIDOC March and Family Fun Day and Awards in Tamworth on July 7 at Bicentennial Park. Ability Links had a tent set up at the event and participated in the march and day's festivities. Bec said it was the biggest march she'd ever seen, and took... View Article


text: AppearanceEdit PersonalityEdit HistoryEdit Retrieved from "http://hellblade.wikia.com/wiki/Hyde?oldid=4146" Ad blocker interference detected! Wikia is a free-to-use site that makes money from advertising. We have a modified experience for viewers using ad blockers Wikia is not accessible if you've made further modifications. Remove the custom ad blocker rule(s) and the page will load as expected. Categories: Male Add category Cancel Save


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Grime on unwashed windows blocks sunlight, causing houseplants to turn toward the light of a TV set or birthday cake. Let plants look out windows with this Groupon.
Choose Between Two Options
- $69 for basic window washing for up to 20 windows on one story (up to a $160 value)
- $129 for basic window washing for up to 40 windows on up to two stories (up to a $320 value)

Basic window washing includes a cleaning of exterior windows.

Lawn Runners
Lawn Runners keeps yards tidy with lawn-care services scheduled on a regular or one-off basis, which ensure that ground hairs remain closely cropped, fertilized, and cleaned of winter or fall debris. Window and glass cleanings power-wash grime and neighborhood urchins off skylights, and junk or debris removal removes nonhazardous clutter, such as construction debris, appliances, and old furniture.


text: First time posting here, very nice site! Who can tell me what angle to sharpen a Ninja Blade? I sharpened mine today and I could have sworn I followed the previous angle but, it seems it is leaving some grass down the middle that isn't being cut quite as well as the rest. The only thing I can think of is that I got the angle wrong?


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Congratulations to our four Sunrise Senior Living communities that were recently recognized with a Silver – Achievement in Quality Award by the American Health Care Association and National Center for Assisted Living (AHCA/NCAL).
The award is part of AHCA/NCAL's National Quality Award Program, which honors long-term and post-acute communities across the United States that demonstrate a continued commitment to providing residents with quality care. The following four Sunrise communities were recognized with this year's Silver Award:
- Sunrise of Decatur (Decatur, GA)
- Sunrise of Johns Creek (Johns Creek, GA)
- Sunrise at Webb Gin (Lawrenceville, GA)
- The Stratford (San Mateo, CA)
"These …read more


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With the legendary Mapei team still looming large in the imagination of the cycling enthusiast, the Colnago C60 Limited Edition Mapei Electronic Frameset (Sloping Geometry) allows you to relive the glory days of the early 1990s pro-circuit whilst benefitting from the very best that modern cycling technology has to offer.
Colnago C60 Limited Edition Mapei Electronic Frameset (Sloping Geometry)
Ordered on demand
UK, EU and Worldwide delivery available.
Colnago C60 Limited Edition Mapei Electronic Frameset (Sloping Geometry)
Transporting you back to the glory days of the indomitable Mapei team, the Colnago C60 Limited Edition Mapei Electronic Frameset (Sloping Geometry) features a limited edition paintwork that's an exact replica for the paintwork on this Paris-Roubaix dominating team's original bikes. Regaled on this modern road racing machine of the very highest order, this is a very special edition bike for anyone looking for contemporary technology, with retro styling.
This paintwork covering Colnago's top of the line carbon fibre C60 frameset, the rider can benefit from a strong, stiff and responsive frame at the heart of their performance, assuring them of a top quality transfer of power. Oversized tubing making this an integrally strong option, the elements of this frame are bonded together using Colnago's unique and patented lugging process, reinforcing the frame and eliminating any rear flex. An oversized bottom bracket improving rigidity at the crucial juncture, this frame also benefits from a tapered headtube for a top quality control and feel when riding.
This version benefiting from a sloping geometry that allows for an improved standover height and a more nimble and agile feel, you can make use of a longer seatpost to provide you with the easy seating and comfortable platform on your ride. Compatible with electronic shifting setups, this is a high quality, modern pro-level bike, kitted out with the decals of days gone past.
- Includes: Frame, fork, and headset
- Made from Colnago's stiff and supremely crafted carbon fibre
- Tapered headtube for compliant control
- High-quality graphic replica of the Mapei team bikes
- Pioneering asymmetrical seat tube design
- Oversized bottom bracket for improved rigidity
- Internal cable routing
- Electronic groupset compatible
- FRAME: Colnago C60 Italia Dual Routed, Sloping Geometry
- FORK: Colnago carbon, 1-1/8" to 1-1/4" steerer
- HEADSET: Colnago CHS-1
- SEAT CLAMP: Colnago
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All our bikes are fully checked and tuned and tested by our Cytech qualified mechanics and then securely packaged, ready for despatch. All you have to do is add the pedals, rotate and tighten the handlebars. Typically we can deliver your bike in 4 - 5 working days.
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We offer a free returns service for our UK customers. Sigma Sport will happily refund or exchange any item purchased at Sigma Sport, excluding Sigma Sport gift vouchers and personalised products except when faulty.
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