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Jobs in Chicago, Illinois (US)
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Found 21 jobs in this campaign
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Postdoctoral Scientist
Multiple Postdoctoral Scientist positions are open in the laboratory of Dr. Ryan M. Drenan in the Department of Pharmacology at Northwestern Univer...
Postdoctoral Position at the University of Chicago
Postdoc Position at UC in the lab of Anning Lin, PhD to study signaling mechanism involved in inflammation, cancer and neuronal degenerative disease.
Water-Related Molecular Engineering, Assistant Professor/Associate Professor/Professor
University of Chicago's IME invites applications for one or more faculty positions, at all ranks, in the area of Water-related Molecular Engineering.
Postdoctoral Scholar, Single-cell analysis methods
Applications are invited at the Systems Biology and Bioengineering Group to develop single-cell analysis methods and microfluidic systems.
Assistant, Associate or Full Professor - Anatomy & Cell Biology (Job ID #83516)
Assistant, Associate or Full Professor (Job ID #83516) Department of Anatomy and Cell Biology UNIVERSITY OF ILLINOIS AT CHICAGO The Department of A...
Faculty Position in Regenerative Biology
Feinberg Cardiovascular Research Institute is recruiting a tenure-track scientist or physician-scientist in the area of regenerative biology.
Dean of the Graduate College of Rush University
Rush University Medical Center invites applications for the position of Dean of the Graduate College of Rush University.
Postdoctoral Scholar in Computational Biology/Cancer Genomics
The Yang Lab is seeking self-motivated individuals with strong background of computational biology to study cancer genomics. The main goal of the l...
Microbiology Faculty Position
Candidates should have interest in developing approaches to cultivate, propagate, and interrogate microbial species or consortia.
Faculty Positions in Host-Pathogen Interactions
Faculty Positions in Host-Pathogen Interactions - Department of Microbiology and Immunology at University of Illinois at Chicago
Non-Tenure Track Assistant Professor
A non-tenure track faculty position of Assistant Professor is available in the Department of Physiology at the University of Tennessee Health Scien...
Assistant Professor of Chemistry
Position Title: Assistant Professor of Chemistry Req # 03393 The Department of Chemistry at The University of Chicago invites applications for the ...
postdoc fellow
A postdoctoral fellow position is available in Dr. Li Lily Wang's laboratory, in the department of Microbiology & Immunology, Medical College of Wi...
Faculty Director of the Duchossois Family Institute
Faculty Director of the Duchossois Family Institute The University of Chicago's Biological Sciences Division (BSD) invites applications for the pos...
KICP Postdoctoral Research Fellow 2018
KICP Postdoctoral Research Fellow 2018 The KICP announces its 2018 Postdoctoral Research Fellowship competition. Scientists receiving a PhD in ...
The Lake Forest College Biology Department invites applications for a tenure-track faculty position at the Assistant Professor level.


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Integration for Swift code
Follow the steps below Download the sdk zip file which have some files library (.a file), header file (.h file), and an image (.png file), from sdk download link and include them into your project. Simply drag and include them in your project.Download IOS SDK
1. Configure your info.plist
Open info.plist of your project as source code (right click on info.plist and click on Open as >> Source code) and add the following code in it.
<string>Your Project Identifier Name</string>
<string>location is required for geofence</string>
<true/><!--OR--><!-- <false/>-->
You can simply open the info.plist and add the keys which works as same as above for this.
1.1. Add a new row by going to the menu and clicking Editor > Add Item. Setup a NSAppTransportSecurity as a Dictionary
1.2. Added a Subkey called NSAllowsArbitraryLoads as Boolean and set its value to YES as like following image
1.3. Add a new row again and set up a URL Types item by adding a new item. Expand the URL Types key, expand Item 0, and add a new item, URL schemes. Fill in "appScheme" for Item 0 of URL schemes and your company identifier for the URL Identifier. Your file should resemble the image below when done
1.4. Add a new row again and set up a NSLocationAlwaysUsageDescription as String and fill this field with the message you want to show in alert box for asking user permission for geofencing (example: location is required for geofence)
1.5. Add a new row again and set up a nvBrandID as Number and fill this field with your BRANDID
1.6. Add a new row again and set up a nvSecretKey as String and fill this field with your SECRET KEY
1.7. Add a new row again and set up a nvPushCategory as String and set it's value nvpush
1.8. Add a new row again and set up a key nvViewAutoRedirection as Boolean set it YES to enable auto redirection of your app's ViewControllers from sdk or set it NO to handle redirections by your app
1.9. Goto Capabilities Tab and turn the Background Modes switch on.To do that select the project from the Project Navigator then select the app target then select the Capabilities tab, and turn the Background Modes switch on .Select 3 check boxes (i.e. Location updates,Background fetch,Remote notifications)
In the Capabilities Tab Turn On Push Notifications and if you are upgraded Xcode 8.0 or later and Push Notifications was turned on in previous version turn off Push Notifications and turn on it again to configure push notification properly for the upgraded devices.
Add a new header file and name it with following format. YOUR_PROJECT_NAME-Bridging-Header.h Example if your project name is test. Then the header file name will be test-Bridging-Header.h. Now add the following import statement in YOUR_PROJECT_NAME-Bridging-Header.h for accessing Native SDK Classes.
#import "notifyvisitors.h"
Make sure that the path of bridge-header.h file is included in build settings under "Swift compiler-code generation" as:
Objective C bridging header:YOUR_PROJECT_NAME/YOUR_PROJECT_NAME-Bridging-Header.h
2. Initialise the SDK
Initialize the sdk in application didFinishLaunchingWithOptions function.
Define a String nvMode and set its value "debug" or "live" based on preprocessor if condition so that sdk knows the app is running in debugging mode or downloaded from AppStore (i.e. live mode) as follows.
func application(application: UIApplication, didFinishLaunchingWithOptions launchOptions: [NSObject : AnyObject]?) -> Bool {
var nvMode:String? = nil
#if DEBUG
nvMode = "debug"
nvMode = "live"
Add the following method in application didFinishLaunchingWithOptions to register your app for push notification and geofencing.
notifyvisitors.registerPush(withDelegate: self, app: application, launchOptions: launchOptions)
Add the following three function inside your AppDelegate file to handle the registering and receiving events of push notification.
func application(application: UIApplication, didRegisterForRemoteNotificationsWithDeviceToken deviceToken: NSData) { notifyvisitors.DidRegisteredNotification(application, deviceToken: deviceToken)
func application(application: UIApplication, didFailToRegisterForRemoteNotificationsWithError error: NSError) { print(error)
func application(_ application: UIApplication, didReceiveRemoteNotification userInfo: [AnyHashable : Any]) {
notifyvisitors.didReceiveRemoteNotification(userInfo: userInfo)
iOS 10 Push Notification Handler
For iOS 10 Push Notification Add the following Delegate Methods in AppDelegate file.
Goto AppDelegate file import UserNotifications framework and also add UNUserNotificationCenterDelegate to support iOS 10 Push Notification or Rich media push notifications.
import UserNotifications
class AppDelegate: UIResponder, UIApplicationDelegate, UNUserNotificationCenterDelegate {
Now add the following delegate methods into AppDelegate file to handle iOS 10 push notifications.
@available(iOS 10.0, *)
func userNotificationCenter(_ center: UNUserNotificationCenter, willPresent notification: UNNotification, withCompletionHandler completionHandler: @escaping (UNNotificationPresentationOptions) -> Void) {
notifyvisitors.willPresent(notification, withCompletionHandler: completionHandler)
func application(_ application: UIApplication, didReceiveRemoteNotification userInfo: [AnyHashable : Any], fetchCompletionHandler completionHandler: @escaping (UIBackgroundFetchResult) -> Void) {
notifyvisitors.didReceiveRemoteNotification(userInfo, fetchCompletionHandler: completionHandler)
@available(iOS 10.0, *)
func userNotificationCenter(_ center: UNUserNotificationCenter, didReceive response: UNNotificationResponse, withCompletionHandler completionHandler: @escaping () -> Void) {
Add Notification Service Extension to support Rich media Attachment in iOS 10 push notification.Kindly refer step 8 for Notification Service Extension creation guide.
To handle the geofencing notifications in background state and Inactive state of application add the following code in applicationDidEnterBackground and applicationDidBecomeActive respectively.
func applicationDidEnterBackground(application: UIApplication) {
notifyvisitors.NotifyVisitorsGeofencingApplicationDidEnterBackground() }
func applicationDidBecomeActive(application: UIApplication) {
notifyvisitors.NotifyVisitorsGeofencingapplicationDidBecomeActive() }
Add the following Code to receive local notification when geofencing events trigger.
func application(_ application: UIApplication, didReceive notification: UILocalNotification) {
Deep Linking
Call the following function in your AppDelegate openURL function that will check the deep linking and open your app from URL Scheme.
func application(application: UIApplication, openURL url: NSURL, sourceApplication: String?, annotation: AnyObject) -> Bool {
notifyvisitors.openUrl(with: app, url: url)
return true
Give the Storyboard ID to all of your View Controller same as its name for example if you have a View Controller named HomeViewController then it's Stroryboard ID should be HomeViewController. Do it for all view controllers in storyboard.
3.Showing In-App Notifications
Use following function to show in app popups. Pass the User Token & CustomRule as NSMutableDictionary or pass nil.
notifyvisitors.Show(UserToken , CustomRule:CustomRule )
notifyvisitors.Show(nil , CustomRule:nil )
notifyvisitors.Show(TokenMutableDictionary , CustomRule:CustomRule )
If you are using UIScrollView use the following function in your ScrollView delegate method ScrollViewDidScroll to View Notification on specific scroll position.
func scrollViewDidScroll(scrollView: UIScrollView) {
notifyvisitors.scrollViewDidScroll(scrollView) }
If you need to dismiss all inApp notifications currently viewing on screen, you can call DismissAllNotifyvisitorsInAppNotifications method like this:-
4. User Identifiers
To identify the different app users, call the method userIdentifier as follows.
notifyvisitors.UserIdentifier("userID" , jsonData:jsonDataMutableDictionary )
5. Showing Notification Center
You can show list of push notification received push notifications in an In-app Notification Center. To launch In-app notification center you can call the following method.
6. Tracking events
To track the various app events, call the method event like:-
notifyvisitors.trackEvents:("eventName" Attributes:AttributesDictionary lifetimeValue:"Ltv" Scope:scope )
Where: eventName is the name of the event you want to track for example "sale", AttributesDictionaryis the json (Key Value Pair) containing different properties of the event in the form of json object like:-
var AttributesDictionary = NSMutableDictionary (dictionary: dictionary)
AttributesDictionary["price"] = "2000"
AttributesDictionary["Category" ] = "fancy"
Ltv is the value you want to give to user corresponding to every particular event.
scope - 1 (called every time the function is called)
scope -2(called once for the session)
scope -3 (called once per lifetime)
7. Handle Call to Action Manually
This point is optional if your apps action button action not working to load your app's view controller you can handle it yourself using NSNotificationCenter to do that add the following code anywhere in your app recommended is inside viewDidLoad of first View Controller.
NotificationCenter.default.addObserver(self, selector: #selector(self.triggerAction), name:NSNotification.Name(rawValue: "NVInAppViewConroller"), object: nil)
From above code your app will be notified on tap on action button if you set action button to open your in-app view controller on notifyvisitors control panel and now you can be able to handle the action as following method.
@objc func triggerAction(notification: NSNotification){
print("notification received \(notification.userInfo)")
// Do your stuffs here…………………………………………………………..
8. Notification Service Extension
Create a Notification Service Extension in your project. To do that, in Xcode, select File >> New >> Target and choose the Notification Service Extension template.
Define a name for the Notification Service Extension as given below :
Once the target is created, Activate the scheme for Extension when prompted for the same. After this your extension will be added to project you will see a class with the extension name provided by you while creation and .plist file associated with it.
Now Open info.plist of your Notification Service Extension as source code (right click on info.plist and click on Open as >> Source code) and add the following code in it.
<key>App Bundle identifier</key>
<string>"Your App's Project Identifier Name"</string>
You can simply open the info.plist and add the keys which works as same as above for this.
1.1Add a new row by going to the menu and clicking Editor > Add Item. Set a key App Bundle identifier as a String and set its value to your app's Bundle Identifier.
1.2Expand the NSExtension and add NSExtensionAttributes as Dictionary. Inside NSExtensionAttributes dictionary add a key UNNotificationExtensionDefaultContentHidden as Boolean its value should be YES and add another key UNNotificationExtensionInitialContentSizeRatio as Number its value should be 0.7 as the following preview.
Goto Build Phase tab of your Notification Service Extension target and click on "+" sign under Link Binary With Libraries and click on "Add Other…" from promoted box and add the reference of our sdk .a file from your apps project folder (Don't give reference of .a file from outside of your project).
Add a new header file and name it with following format. YOUR_EXTENSION_NAME-Bridging-Header.h in your Notification Service Extension. Example if your extension name is testExt. Then the header file name will be testExt-Bridging-Header.h. Now add the following import statement in YOUR_EXTENSION_NAME-Bridging-Header.h for accessing Native SDK Classes.
#import "notifyvisitors.h"
Make sure that the path of bridge-header.h file is included in build settings under "Swift compiler-code generation" as:
Objective C bridging header:YOUR_EXTENSION_NAME/YOUR_EXTENSION_NAME-Bridging-Header.h
Goto NotificationService.m file and update didReceiveRequestWithContentHandler delegate mehod as follows:
override func didReceive(_ request: UNNotificationRequest, withContentHandler contentHandler: @escaping (UNNotificationContent) -> Void) {
self.contentHandler = contentHandler
bestAttemptContent = (request.content.mutableCopy() as? UNMutableNotificationContent)
let userInfo: [AnyHashable: Any]? = request.content.userInfo
if userInfo == nil {
var FileData: [AnyHashable: Any] = notifyvisitors.getmediaInfo(userInfo)
let FileUrl: String? = FileData["mediafile"] as? String
let FileType: String? = FileData["filetype"] as? String
if FileUrl == nil || FileType == nil {
notifyvisitors.getAttachmentData(forFileUrl: FileUrl, withFileType: FileType, completionHandler: {(attachment:UNNotificationAttachment?) ->Void in
if (attachment != nil) {
self.bestAttemptContent?.attachments = [attachment!]
func contentComplete() {
if let contentHandler = contentHandler, let bestAttemptContent = bestAttemptContent {

subset: commoncrawl


text: Dissertation of the Year Award for 2017—nomination deadline, July 15, 2017 The Language and Social Interaction Division of the National Communication Association (http://www.nca-lsi.org/) will recognize the outstanding doctoral dissertation in the field of Language and Social Interaction. Nominations should reflect the division's focus on situated language usage and social interaction. Analyses of both institutional and everyday interaction, in face-to-face and mediated contexts, and interact...More


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Dominic Murphy, the executive behind one of KKR's most successful investments, is leaving the buyout firm. Mr Murphy was instrumental in orchestrating the £12bn acquisition of UK pharmacy chain Alliance Boots in 2007, in what became Europe's largest leveraged buyout, as well as its subsequent merger with US rival Walgreens.
Walgreens Boots Alliance, Inc. today announced that affiliates of Kohlberg Kravis Roberts & Co. L.P. intend to offer for sale, in an underwritten secondary offering, 15,000,000 shares of the company's common stock. Dominic Murphy, a senior executive at KKR, will remain a member of the company's board of directors after the completion of the proposed offering.


text:
Help with chylothorax needed!
Expand Messages
- My cat Clawed, who was diagnosed with heart disease last September,
developed chylothorax (presumably due to the heart disease) last week.
He has had to have it drained twice, so I am looking for others'
experience in controlling this. He was just put on prednisone
yesterday. Also, the vet recommended a low fat diet. I am thinking
of making him thhe low-fat meat diet in Dr. Pitcairn's book.
I welcome ANY suggestions, thoughts, etc.
I'm on website-only, so I will check a few times each day, but if you
want to reach me straight away you can email me at NWL1 @
tampabay.rr.com .
Your message has been successfully submitted and would be delivered to recipients shortly.


text:
LONDON, April 13 (Reuters) - Britain's FTSE 100 futures contract slipped 0.3 percent on Monday, and the cash market was also expected to ease back off record highs with weak China data set to weigh on mining stocks. For more on the factors affecting European stocks, please click on
* The UK blue chip index ended up 1.1 percent at 7,089.77 points on Friday, its highest ever closing level. It had earlier set an intraday record high of 7,095.36 points on Friday as well.
* UK ELECTION: Britain's opposition Labour party have taken a 3 percentage point lead over Prime Minister David Cameron's Conservatives according to a YouGov opinion poll ahead of the May 7 general election.
* CHINA DATA: Data showed China's export sales contracted 15 percent in March while import shipments fell at their sharpest rate since the 2009 global financial crisis, a shock outcome that deepens concern about sputtering Chinese economic growth.
* OIL: Oil prices inched up on Monday following a strong session on Friday.
* COPPER: London copper was flat on Monday after surprisingly weak China trade data was offset by a jump in March copper imports, which were plumped up by bookings made a month earlier when imports were cheaper.
* EASYJET : British low-cost airline easyJet named Andrew Findlay as its new chief financial officer, poaching him from bicycle retailer Halfords .
* ICAP /HISCOX : ICAP Plc, the world's largest interdealer broker, said it had appointed British insurance veteran Stuart Bridges as it group finance director.
* FALKLAND OIL & GAS : Falkland Oil and Gas (FOGL) said on Monday it had decided together with its joint venture partners Noble Energy and Edison International to shelve plans to drill a second oil well in the south and east Falkland basin.
* WINCANTON : British logistics company Wincanton Plc said on Monday Eric Born, its chief executive of six years, intended to step down to take on another job.
* TRAVELODGE: The owners of UK budget hotel chain Travelodge are preparing to appoint advisers to consider strategic options, including a sale that may value the company at more than 1 billion pounds ($1.46 billion), The Times reported on Sunday.
* CRYSTAL AMBER/PINEWOOD: The Crystal Amber fund is eyeing a new stake in Pinewood Studios, the Financial Times reported.
* CO-OP: Co-Op Group members have revolted over the company's boardroom elections, The Guardian reported.
> Financial Times
> Other business headlines Multimedia versions of Reuters Top News are now available for: * 3000 Xtra : visit topnews.session.rservices.com * BridgeStation: view story .134 For more information on Top News visit topnews.reuters.com (Reporting by Sudip Kar-Gupta; Editing by Blaise Robinson)


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by: Chango
There is a power struggle going on between him and a woman; a woman who is internally enmeshing him and not only earning the trust and confidence of voters and the people of the town.
What people do not know is that this woman, this being that comes with such apparently good intentions and eager to organize the economic and moral situation of the country, and boasts of solution to problems, is nothing more than a façade, is nothing more than a mask concealing their true intentions.
Quite difficult for the place and the people who inhabit it. It comes in a time where violence is increased, where it will be increasingly complicated to live there, where people are deprived of many rights, where they will see that, foe evil or good, in one way or another, would be better with its current president.
On the question of whether President Aquino will (attempt to run) for next period, yes, he will try too, but will not succeed and not manage to get there, as people lose faith in what he has done and what he will do. Sadly this place, Philippines for some years will not be so good place to live, insecurity, economic situation and many other factors begin to be affected even more than before.
Photo: Aklan Forum
A collection of predictions from renowned psychics across the globe, covering world and local events, politics, entertainment, environment, spirituality, and more. Genuine and best psychics in the Philippines and worldwide!
Sunday, October 19, 2014
President Benigno Aquino III
5 comments:
- AnonymousOctober 19, 2014 at 6:29 PM
A woman...hmmmReplyDelete
- AnonymousOctober 20, 2014 at 12:14 AM
CJ SERENOReplyDelete
- AnonymousOctober 20, 2014 at 9:25 PM
The best option for him is to just finish this term, and make sure he leaves a good foundation for the next president.ReplyDelete
way to go Philippines!ReplyDelete
- AnonymousOctober 23, 2014 at 12:09 AM
poor philippines, even a foreigner like Mr. Chango sees it as such.ReplyDelete
Subscribe to: Post Comments (Atom)


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Lightly roasted in olive oil and sea salt, this Warm Roasted Sweet Potato Salad has a crisp, dense texture and a slightly sweet fresh taste.
- 2 1/2 pounds sweet potatoes, cut into chunks
- 1 tablespoons olive oil, divided
- ½ teaspoon coarse sea salt
- 3 cups lettuce greens,chopped
- 1/8 cup freshly squeezed orange juice
- 2 tablespoons honey
- 3 green onions, thinly sliced
- ¼ cup chopped cilantro
- 1/3 cup grated Parmesan cheese
- salt and pepper, to taste
- Preheat the oven to 400 degrees F.
- Add the chopped sweet potatoes to a large baking pan and drizzle with olive oil. Sprinkle with ½ teaspoon salt and toss to coat.
- Arrange the potatoes in a single layer.
- Bake for about 40 to 55 minutes, stirring occasionally, until the potatoes are tender and soft.
- In a small bowl, whisk together the orange juice, honey and ½ tablespoon olive oil. Set aside.
- When the potatoes are done cooking, add them to a large bowl.
- Add the lettuce greens, green onions, cilantro and Parmesan cheese.
- Add the orange juice mixture to the bowl and toss to coat.
- Season with salt and pepper to taste.
- Serve warm or at room temperature.
Welcome back!
Today's post is part of the monthly themed recipe party called #TheSaladBar. Our hostess is Wendy from the Weekend Gourmet. Our ingredient theme this month is the Sweet Potato. .An excellent choice for the fall season.
And now it's confession time. I despised sweet potatoes as a kid. I didn't like them when mom made them for Thanksgiving. She basically opened a can of yams and heated them up with brown sugar and olive oil. But there was something about them that just didn't appeal to me. I'm thinking there just wasn't enough chocolate added. I was a picky eater and veggies were not my friend at all. Mom made mush of them and I didn't like mush.
But several years ago, my friend order sweet potato fries and let me taste one. Um, let's just say, I totally did not know what I was missing all these years.
So for those of you who are not a sweet potato fan. Try them again, you might just surprise yourself.
Enjoy the rest of the Sweet Potato Salad recipes!


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Little Rhymes For Little People
$60.00 Add to cart
Product Information
Little Rhymes for Little People. Syracuse, NY: Merrell-Soule Co., c. late 1800's early 1900's. 3 x 4.5 in. A little booklet of rhymes put out by None Such Mince Meat. The booklet, marketed towards children, in hopes "it will please the little folks and be the means of persuading the older ones who are not acquainted with the merits of the None Such Mince Meat to give it a trial". Lovely illustrations (in both color and black and white) fill the pages and give the booklet a certain charm. Near pristine with .5 cm closed tear to front cover corner. Clean and crisp copy. Orig. color illustrated wraps. Very Good. Staplebound.


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Audit, Visiting, and Returning Students
Admission requirements and procedures differ for some students.
If you wish to take university classes solely for interest's sake, auditing classes may be an option for you.
Auditing a class means that you are able to attend lectures but do not hand in assignments, participate in class discussions, or write mid-term or final exams. You will not receive credit for the classes you take, but will pay lower fees and are exempt from many admission requirements.
To apply to become an audit student, select the "Audit Student" application type when you apply online.
If you are enrolled at another institution and you want to take University of Saskatchewan classes to transfer to your degree program, you may apply as a visiting student.
When you apply, you will need to provide a letter of permission from your home institution stating that you have approval to attend the University of Saskatchewan, indicating the intended term of study, and identifying the specific course(s) in which you intend to enroll.
To apply to become a visiting student, select the "Visiting Student" application type when you apply online.
Saskatchewan students enrolled at the University of Saskatchewan, University of Regina, and Saskatchewan Polytechnic
As a Common Visiting Student, you may take distance and off-campus classes offered by a Saskatchewan partner institution. A visiting student is eligible to take classes at the U of S with a letter of permission provided by their home institution with the intent of transferring earned credit back to the home institution. A letter of permission is required for admission. Talk to the advisor at your off-campus site for more information.
If you have previously completed classes at the U of S, have not attended another post-secondary institution, and want to return to the same college, you should apply for readmission as a returning student. Please note that you must meet returning application deadlines.
If you still have access to PAWS, you can apply for readmission through the Admissions channel. Select "Returning Student" as the application type.
If you do not have access to PAWS, please begin a new application. You may still select "Returning Student" as the application type.
Use the "Current U of S Student" application if you want to apply to a college other than the one in which you were previously enrolled. If you have completed classes at another post-secondary institution since you last attended the U of S, you should apply as a "Transfer" student; remember, if you have completed classes at the U of S previously, you do not need to submit another application fee.
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text:
In the wake of the release of their 6th studio album, Hydrograd (due June 30th), Stone Sour have announced their plans for a European/UK Tour later this year. Continue reading "Stone Sour European/UK Tour 2017"
Tag: Metal
'Iron Maiden: The Complete Albums Collection 1990-2015'
So this little beauty came in the post yesterday. Featuring two LPs, and a box set to complete over the coming months, Iron Maiden are starting to roll out their next lot of vinyl re-issues. Continue reading "'Iron Maiden: The Complete Albums Collection 1990-2015'"


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Samsung Galaxy S8 Plus reviewRecommended
Updated The big Samsung Galaxy S8 Plus is here. We have a mega-sized review of the phone to match.
Updated The big Samsung Galaxy S8 Plus is here. We have a mega-sized review of the phone to match.
Access EdgeCast, G-Core, MaxCDN and Highwinds from this simple multi-CDN.
MINI REVIEW The Anker SoundCore 2 isn't the best-sounding speaker – but, for the price, it remains a great value.
Downloads A fun, easy way to transform your landscape photos with dramatic skies and lighting.
Updated By sitting back and refining its winning product, Dell has managed to make yet another winning Ultrabook.
After the smash hit success of last year's NES Mini, Nintendo is following up with its next retro console.
Polar wants to tease you away from Fitbits with the promise of GPS tracking in a band.
Sony's flagship noise-cancelling headphones are a killer pair of cans with a few tricks up their sleeves.
Updated If you were hoping for refinement out of 2017's MacBook Pro refresh, then you're in luck – just don't expect a revolution.


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Family Tree Wall Decals for Nursery Ideas
Parents and children can have tree wall decals for nursery. Neutral gender theme allow boys and girls to have such nursery decor to pour into their room. Wall decals are available in so many themes but if you want to have one that represents each and everyone of people in the house, tree could be a fine choice. Different trees like birch are looking cute especially with the white color that features neutrality.
Birds and trees are a fine combination to pour into baby's room. Owl is popular for today. Just pick the right colors to meet your baby gender style or choose neutral colors like brown and white. Flying and perching owls around the trees make the walls look so alive. Try out wall decal appliques for the purpose. Its textured style looks impressive and you can add some 3D features as well.
Not only for baby room nursery decor, the decals are also cute for family room. We have white family room walls with black tree decals. We have some photos are placed on some the decal branches as addition and to feature family nursery value. Our kids love them and indeed we do as well.
Michaels has some interesting tree wall decals. Simple shapes on wall designs are for sure to make a better home and living inexpensively. You can access his official site michaels.com or some others like weedecor.com and etsy.com. Each one of them has unique offerings related to tree wall decals for family room decor and nursery theme ideas.
Big tree wall decals are for sure to add pleasing to the eyes and the heart home interior decor. Bear in mind about colors of other features like furniture, rugs and curtains for harmonious beauty. Neutral tree colors are wonderful but you can have some of the leaves colored. For instance, pink for the girl, blue for the little boy and brown or red for the parents.
It is simple but a thing for sure to add wonderful values in your family room as one of the most significant home improvement ideas. Have the walls in white or stripes or others based on your room decor. Nursing all family members and improving your home with Tree Wall Decals for Nursery are obtainable just in one way.Incoming search terms: tree wall decals for nursery, etsy birch tree wall decal, white tree nursery decal, white tree wall decals


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666: The Mark of the Beast
In New York City, it is common to receive religious advice while buying coffee or condoms or walking your dog. This guidance may come calmly, from someone on the train who wants to talk about God. It may come in … Continue reading


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One of my relatives parked her car at a shopping mall (where we normally get pizzas) on Good Friday and left on an outside errand. When she returned to the mall, her car had been towed to a place 2 kilometres away. She was forced to pay $350 in cash to get her vehicle back. There were very few vehicles in the lot, as most stores were closed. Is this ethical?
The only time I've had to appear as a defendant in a court of law was after I chose, in a fit of Sabbath pique, to have a car towed from our church parking lot. The lot was properly signed, but this guy had been parking there for weeks.
We put polite notes on his bucket-o-bolts, and when those failed, we called the cops. All to no avail: that municipality had no bylaw preventing parking in lots such as ours, so the cop said: "Tow him!"
I did, the owner charged the church with illegal towing and — believe it or not — we were found guilty.
Now, before you waste excess sympathy on our wretched plight, you should know we were fined exactly $1 — and Felonious Parker was warned by Hizzoner never to show his sorry puss in his courtroom again. Sometimes, to quote Charles Dickens' Mr. Bumble, "the law is a ass."
You will, therefore, understand why I have some sympathy for the mall owner. Mall lots are private property, not public facilities. The right to park is limited to at-the-time customers; lots are usually signed to that effect. Nowadays, most municipalities have bylaws permitting owners of such land to enforce those conditions. Abandoning your car in a mall lot, jumping on the subway and returning six hours later is essentially the same as leaving it in someone's driveway while visiting their neighbour.
So yes, in that strict sense, it was ethical to remove the car.
But another principle of ethics (warbled so lyrically by the Mikado) is "let the punishment fit the crime" — and in this case, the penalty was outlandish.
Unless your relative was driving an 18-wheeler, $350 is an outrageous cost for a 2-km tow.
Then the towing company required that she pay the bill on the spot, in cash, before releasing her car; they had no right to do that. That's bullying, pure and simple. Had your relative been unable to pay or chosen to contest the charge, the company needed to release her car, and pursue payment through normal channels available to any other business. The dentist doesn't hold your kid hostage 'til you pay for her filling; by what right does the Happy Hooker garnishee your wheels?
And finally, it was Good Friday, and while that doesn't make parking on private property OK, the stores were closed; that makes the mall's action ethically, if not legally, shaky.
There's no point trying to deal with the towing company; that's like spitting into the wind. Your relative should speak to mall management. Remember — the towing company was acting as their agent.
Ask for partial redress for the outrageous charge. If none is forthcoming, order your pizza somewhere else. And park on the street.
Send your questions to firstname.lastname@example.com
Send your questions to firstname.lastname@example.com


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Mācību centrs +371 20400777
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Professional training program
The professional training center SPA SCHOOL announce sthe intake of students for "SPA SPECIALIST" professional training program. SPA SCHOOL graduates receive TWO documents: Latvian professional qualification certificate and ITEC INTERNATIONAL DIPLOMA that is recognized in over 35 countries worldwide!
With conferment of "SPA SPECIALIST"profession
(LR Board of Education license Nr. P-6090, Accreditation Nr. AP 1646)
Nowadays the profession of a SPA SPECIALIST is becoming especially needed. It is connected with
an active development of SPA branch and also a great interest of people who visit SPA salons and SPA centers in order to improve their health, aesthetic appearance, and to release their emotional tension.
SPA SPECIALIST – it is a specialist who is working in the industry of beauty. This specialist has a right to work in beauty salons and SPA centers as a "SPA SPECIALIST", and also may keep private practice in the appropriate specialty.
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Get an actual PROFESSION and WORK WORLDWIDE!
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and many other things…
At the conclusion of studies the graduates receive TWO DOCUMENTS CONFIRMING their PROFESSIONAL EDUCATION:
1. LR Professional QualificationCertificate (Latvijas Valsts apliecība par profesionālo izglītību) that provides its holders with a "SPA SPECIALIST" qualification and enables them to obtain employment in the appropriate profession in Latvia.
2. ITEC International Diploma (London) that provides its holders with professional education and that is recognized in over 35 countries worldwide (UK Accreditation: QAN 500/7458/1 Level 3).
ITEC International Diploma conforms to the international standards and enables its holders to obtain employment in SPA, Wellness and Beauty industries (at hotels, salons, health resorts) in more than 35 countries of the world, including also Great Britain, Ireland, the USA,countries of the EU, Australia and Asian countries. (www.itecworld.co.uk)
The training programs and teaching staff are approved by ITEC international examonation board (London).
Examinations and tests are held with direct involvement of ITEC examiners from Great Britain.
To enter a course of study it is necessary to present the following documents:
• a copy of the passport
• SPA SCHOOL filled in application form
• two photos (3x4 cm)
• the Certificate of Secondary or Higher Education
• It is necessary to enter into a contract of apprenticeship
The mentioned documents are acceptedinthe SPA SCHOOL training center at the following address: Riga, Kalpaka boulevard10, 3rd floor,
Phone: +371 67244455, +371 20400777
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A well appointed and extended 5 bedroom character home, benefitting from 4 reception rooms and conveniently located for the village's amenities and shops.
Requiring a degree of updating and with potential to extend (subject to necessary consents) is this 1950's chalet bungalow with grounds in excess of a third of an acre. No onward chain.
An extended family home overlooking open fields and enjoying a secluded rear garden and superb 32ft kitchen/breakfast/family room.
An imposing 6 bedroom Victorian country house of great integrity set in approximately 2.4 acres of lightly wooded grounds and gardens, located in Eversley with convenient access to excellent commuter links and schools.
An imposing 6 bedroom Victorian country house that has undergone considerably improvement in recent year, set in approximately 2.4 acres of lightly wooded grounds and gardens, with convenient access to excellent commuter links and schools.
Set in approximately 2.5 acres is this unique detached home with accommodation approaching 4800 sq. ft. ideal for an extended family or those looking for generous annexed living space. No onward chain.
A well presented 4 double bedroom detached family home located nearby the town centre and occupying a plot in excess of 0.2 of an acre. No onward chain complications.
This extended 5 bedroom detached family home offers accommodation approaching 2,700 sq.ft. and is situated at the end of an attractive cul-de-sac.
Situated in a pleasant cul-de-sac location is this 5 bedroom detached house with 3 reception rooms and enjoying a 55ft x 50ft rear garden. No onward chain.
A desirable 4 bedroom family home enjoying an enviable position at the end of the cul de sac and overlooking a nature reserve. The property has been very well maintained with a well proportioned kitchen/breakfast room, dining room, living room and a large conservatory.
Due to the fast moving pace of the Short Let market, many of our properties never make it to the website. If you can't find what you're looking for, please give our Short Let team a call as we may have the ideal property for you.


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Rx drug information, pharmaceutical research, clinical trials, news, and more
Aliskiren, the active component of Tekturna ® Tablets, is an orally active, nonpeptide, potent renin inhibitor. Aliskiren is present in Tekturna Tablets as its hemifumarate salt.
Tekturna ® (aliskiren) is indicated for the treatment of hypertension. It may be used alone or in combination with other antihypertensive agents. Use with maximal doses of ACE inhibitors has not been adequately studied.
Prehypertension in Midlife Ups Later Dementia Risk Source: Medscape NeurologyHeadlines [2017.08.10]A study confirms the importance of midlife vascular risk factors on dementia risk and adds new information about risk with prehypertension. Medscape Medical News
Pulmonary Hypertension (Symptoms, Treatment Medications, Life Expectancy) Source: MedicineNet Cirrhosis Specialty [2017.07.26]Title: Pulmonary Hypertension (Symptoms, Treatment Medications, Life Expectancy)Category: Diseases and ConditionsCreated: 12/31/1997 12:00:00 AMLast Editorial Review: 7/26/2017 12:00:00 AM
Hypertension before the age of 55 increases risk of cardiovascular death Source: Hypertension News From Medical News Today [2017.05.19]When someone gets diagnosed with hypertension, either early (before the age of 55) or later in life, can have important health ramifications.
Simple blood tests lead to improved hypertension treatment in African countries Source: Hypertension News From Medical News Today [2017.05.04]Using two simple blood tests, Western University researchers were able to drastically improve treatment for resistant hypertension across three sites in Nigeria, Kenya and South Africa.
Diabetes and hypertension: What is the relationship? Source: Hypertension News From Medical News Today [2017.04.29]Hypertension, or high blood pressure, is linked to diabetes, and each condition can make the other worse. How can people reduce the associated risks?
Effect of naproxen and acetaminophen on blood pressure lowering by ramipril,
valsartan and aliskiren in hypertensive patients. [2013]CONCLUSIONS: Both naproxen and acetaminophen can affect anti-hypertensive therapy
Aliskiren effect on plaque progression in established atherosclerosis using high
resolution 3D MRI (ALPINE): a double-blind placebo-controlled trial. [2013]CONCLUSIONS: MRI quantification of atheroma plaque burden demonstrated that
Comparison of the effects of aliskiren/valsartan in combination versus valsartan
alone in patients with stage 2 hypertension. [2012]The extent to which the combination of a renin inhibitor with an angiotensin
receptor blocker (ARB) lowers clinic and ambulatory blood pressure (BP) versus an
ARB alone in stage 2 hypertension is not well known. Hence, we performed an
8-week, randomized, double-blind study in 451 patients with stage 2 hypertension
to compare the efficacy of the combination of aliskiren/valsartan 300/320 mg
versus valsartan 320 mg...
Long-Term Safety and Tolerability of the Oral Direct Renin Inhibitor Aliskiren with Optional Add-On Hydrochlorothiazide in Patients with Hypertension: A Randomized, Open-Label, Parallel-Group, Multicentre, Dose-Escalation Study with an Extension Phase. [2011.10.13]BACKGROUND: Most patients with hypertension will require combination therapy with at least two agents from different antihypertensive classes to achieve blood pressure (BP) control. Thiazide diuretics, such as hydrochlorothiazide (HCTZ), are widely used in combination therapy. The volume reduction with these agents stimulates the renin-angiotensin system (RAS), making RAS inhibitors such as the direct renin inhibitor aliskiren a logical choice for combination therapy with HCTZ. OBJECTIVE: The aim of this study was to investigate the long-term safety, tolerability and efficacy of the direct renin inhibitor aliskiren, with or without addition of the diuretic HCTZ... CONCLUSION: In patients with hypertension, long-term treatment with aliskiren, with or without add-on HCTZ, is well tolerated and provides effective BP lowering that is sustained over 12 months. TRIAL REGISTRATION: ClinicalTrials.gov Identifier NCT00219037.
Aliskiren as add-on therapy in the treatment of hypertensive diabetic patients inadequately controlled with valsartan/HCT combination: a placebo-controlled study. [2011.10.01]BACKGROUND: Hypertension frequently coexists with diabetes mellitus, resulting in increased cardiovascular risk. Thus, BP control is crucial in decreasing morbidity and mortality in this difficult-to-treat patient population. OBJECTIVE: The objective of this study was to evaluate the efficacy and safety of aliskiren in hypertensive patients with diabetes not adequately responsive to the combination of valsartan and hydrochlorothiazide (HCT)... CONCLUSION: The reductions in BP with aliskiren added to valsartan/HCT in this study were numerically greater compared with placebo added to valsartan/HCT, although not statistically significant. TRIAL REGISTRATION: ClinicalTrials.gov identifier NCT00219102.
Effects of Aliskiren and Amlodipine on the Renin-Angiotensin System (RAS) and Lipid/Carbohydrate Metabolism in Obese Patients With Hypertension [Terminated]
Part 1 determined: aliskiren, amlodipine and angiotensin II concentrations in interstitial
fluid of fat and skeletal muscle; aliskiren and angiotensin II concentrations, and renin
activity and concentration in fat and skeletal muscle tissues (biopsies); aliskiren,
amlodipine and angiotensin II concentrations, and renin activity and concentration in
Part 2 investigated the potential for aliskiren to modulate renin-angiotensin-aldosterone
system (RAAS) activity, and lipid/carbohydrate metabolism in adipose and skeletal muscle
tissue in obese patients with hypertension in comparison to amlodipine.
Vitamin D Augmentation of Tekturna (Aliskiren) in Hypertension [Recruiting]
In this research study, the goal is to find out if a currently FDA-approved medication
called Tekturna(Aliskiren) along with the addition of Vitamin D will lower blood pressure
and improve heart function in the African American population. High blood pressure occurs
earlier in life in African Americans, is more severe, and is associated with greater organ
damage in relation to uncontrolled hypertension. Having low levels of Vitamin D is also very
common in the African American population. Research has shown that there may be a link
between low Vitamin D levels and the ability of high blood pressure medications to be fully
The Effect of Tekturna on Endothelial Function and Endothelial Progenitor Cells in Patients With Early Atherosclerosis [Terminated]
We will study the hypothesis that long-term Tekturna treatment will improve endothelial
function and the production and function of endothelial progenitor cells (EPCs) in patients
with early atherosclerosis. Specifically, long-term Tekturna treatment will increase the
Reactive Hyperemia Peripheral Arterial Tonometry indexes and increase the numbers and the
function of circulating endothelial progenitor cells, compared to placebo, in association
with a reduction in inflammation and oxidative stress.
A Clinical Study to Evaluate Renal Hemodynamic Responses to Aliskiren in Patients With Type 2 Diabetes Mellitus [Completed]
The study objective was to assess the effect of single and multiple doses of aliskiren on
renal plasma flow, glomerular filtration rate and to compare the effects of single and
multiple doses of aliskiren versus captopril or irbesartan on renal blood flow, glomerular
filtration rate, and retinal blood flow in patients with type 2 diabetes mellitus.
Pharmacokinetics, Safety and Tolerability of Aliskiren (SPP100) in Patients With End Stage Renal Disease on Hemodialysis and Matched Healthy Subjects [Completed]
This study will assess the pharmacokinetics, safety and tolerability of aliskiren in healthy
subjects and patients with End Stage Renal Disease on hemodialysis.
Blood Pressure Increased (33),
Hypertension (27),
Drug Ineffective (21),
Dizziness (21),
Cerebrovascular Accident (19),
Diabetes Mellitus (16),
Rash (15),
Blood Pressure Inadequately Controlled (14),
Diarrhoea (13),
Blood Pressure Fluctuation (13), more >>
All Rights reserved - Copyright DrugLib.com, 2006-2017


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Monthly Archives: March 2014
Lego Arrives at Disneyland Paris
Early in 2013, a French employment website posted online an advert for Assistant Managers for a Lego-branded retail store to be opened at Disneyland Paris. The posting, which originally said that the store would be the biggest Lego-branded shop in Europe, was later changed to be much vaguer regarding both the brand and the location. However, this sparked much rumor and speculation throughout the European Disney community as to what this store would be like and when it would open.
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Discovery Cove Offers Florida Residents Getaway Rate
Discovery Cove, located in the heart of Orlando, is an all-inclusive day resort where guests can enjoy a one-of-a-kind opportunity to swim with dolphins, rays and tropical fish and hand-feed exotic birds. Discovery Cove was ranked #1 in the 2013 TripAdvisor's Traveler's Choice Awards under "Top 25 Amusement Parks & Water Parks in The World" category.
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Port Adventures Immerse Disney Cruise Line Guests in Splendor and Culture of Alaska during 2014 Season
During 2014 Alaska sailings, Disney Cruise Line invites guests to explore the grandeur of America's 49th state with a wide variety of fun and exciting Port Adventures.
In preparation for the three-month season of Alaska cruises, Disney Cruise Line worked with local tour operators to create family-friendly excursions that entertain and inspire both children and adults amid Alaska's natural beauty and rich cultural heritage.
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Adventures by Disney Announces New Film-Inspired Norway Itinerary for 2014
The trip-planning specialists at Adventures by Disney, masters of creating family vacations, have teamed up with the pioneers of storytelling on the silver screen – Walt Disney Animation Studios – to offer a new, epic adventure to the land that inspired the look of the upcoming animated feature film Frozen. This tour of Norway allows adventure-seeking families to immerse themselves in the activities that inspired the comedic adventure of Anna, the film's fearless and optimistic protagonist who sets off on a heroic journey to find her sister Elsa and save her kingdom from eternal winter.
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Disney Parks Invites Guests to 'Rock Your Disney Side' With 24-Hour Kickoff to Summer on Both Coasts
140 Disney characters gathered at Walt Disney World Resort today creating the Ultimate Tweet to announce the latest Disney Parks bi-coastal, all-night extravaganza; and guests are invited to show their "Disney Side" by dressing as their favorite Disney hero or villain.
Mickey, Minnie, Donald, Goofy, Pluto and 135 of their friends came together to trumpet the countdown to "Rock Your Disney Side: 24-Hours" this Memorial Day Weekend, the traditional start of the family travel season, when guests of Walt Disney World Resort in Florida and Disneyland Resort in California can enjoy select parks for 24 hours nonstop.
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Avengers Super Heroes Half Marathon Weekend to Swoop into Disneyland Resort in California this Fall
runDisney is expanding its portfolio of race weekends, adding a new Avengers Super Heroes Half Marathon Weekend at Disneyland Resort in Anaheim, CA to debut November 14-16, 2014.
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Lion Country Safari Adds 2 New Water Slides
After 5 months of construction, two brand new water slides are now open at Lion Country Safari. A 108-foot-long freefall water slide and 214-foot-long loop water slide will be the 3rd water activity/addition to the walk-through portion of the 320-acre theme park.
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I spend one night recently and enjoyed my stay. I had a lovely room, which was very quiet. I had a steak with fried potatoes and salat; very tasty home made cooking. Everybody was friendly. I would stay again.
Joined friends staying here for dinner - really welcoming , big shared tables , lovely home made dishes of the day with excellent local specialities. I joined them for dinner on 2 consecutive nights and had excellent roast goose, red cabbage and potato dumplings with...More


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Why Should You Call Clekis?
Chat With Us BelowSpeak To A Live Person
Why Clekis?
Why Choose The Clekis Law Firm?
The Clekis Law Firm offers clients over four decades of experience and customer-focused service as we represented those injured by the negligence of others in Charleston and throughout the Low Country. Since 1989, clients have come first as we fought for justice in personal injury cases.
What Makes The Clekis Law Firm Different?
1) Clekis will come to you. Being injured presents all kinds of limitations. If you're unable to visit to our office, we'll come to you.
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Can The Clekis Law Firm Really Help Me?
The personal injury lawyers at the Clekis Law Firm work only for the plaintiffs – those who were injured as a result of someone else's negligence. We do not work for big business or insurance companies so our clients are people like you who find yourselves in need of restoration after a loss. We fight for the rights of those who were the victims of personal injury, wrongful death, slip and fall, dog and other animal bites, car accidents, tractor trailer accidents, pedestrian injuries, medical malpractice claims, drug claims, healthcare injuries, nursing home abuse and neglect, Workmen's Compensation, Social Security disability, defective product/product liability, and consumer class action causes/consumer fraud. Whatever you are harmed by the negligence of others, we are there for you.
Personal Injury Attorneys
Since 1989, the Charleston personal injury attorneys of Clekis Law Firm have been representing injured people and their families in South Carolina and throughout the Low Country. At the Clekis Law Firm our clients always come first.
As personal injury professionals, we have a duty to protect the rights of victims of personal injury, car accidents, tractor trailer accidents, pedestrian injuries, traumatic brain injury, medical malpractice, prescription drug claims, nursing home abuse and neglect, healthcare injuries, dog and animal attacks, defective products / products liability, slip and fall, wrongful death, consumer class action cases / consumer fraud, workers' compensation and Social Security disability. We do not represent the insurance industry or big business. We represent people like you to put your lives back together.
If you have suffered a serious personal injury due to the negligence of another, don't be victimized twice. You will be up against the insurance industry, big business, and all of their resources. You are not on an even playing field. You need someone on your side to help you obtain the fair and reasonable compensation that you deserve. You need a Charleston personal injury trial lawyer with experience and success in representing injured people.
Insurance companies try to settle claims as quickly and cheaply as possible, because, like every business, their focus is on making a profit. When you have encountered a personal injury through the fault of someone else, the insurance company of the person responsible for your injuries will usually contact you immediately to settle the claim. This happens even when you have serious personal injuries and the full extent of the damage may not be known by you for some time. When this happens, you need a lawyer with your best interests in mind – a lawyer who understands the complexities of personal injury and wrongful death laws.
At The Clekis Law Firm, we understand that suffering a personal injury or losing a loved one due to the negligence of another can be devastating and causes significant hardship and stress. It is of vital importance to obtain the best legal advice possible. Don't settle for less than you deserve; consult an experienced Charleston personal injury law firm as soon as possible. Delays may result in the loss of important physical evidence, and witnesses may forget important details.
You are invited to contact us for a free, no-obligation, and confidential consultation. Our SC personal injury lawyers will analyze your case and advise whether you are entitled to compensation. If we don't think you need an attorney, we will tell you right away.
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The Clekis Law Firm, P.A. will contact you promptly to discuss your concern and answer your questions. For faster results, you may wish to call us at (843) 720-3737.
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Antidepressant Basics
Generic Name: Desipramine
Brand Names: • Norpramin • Treyzafagit • Pertofrane
Class: Antidepressant, Tricyclic
Updated: July 2014
What Is It?
Desipramine hydrochloride, USP is an antidepressant drug of the tricyclic type. Manufactured by Catalent Pharma Solutions. Distributed by Actavis Inc.
What Does It Treat?
Desipramine hydrochloride tablets, USP are indicated for the treatment of depression. Off label uses include the treatment of anxiety, ADHD, cataplexy, chronic itching, bulimia, neuropathic pain, panic attacks, and depression caused by traumatic brain injury.
Some people have thoughts about suicide when first taking an antidepressant. Your doctor will need to check your progress at regular visits while you are using Desipramine. Your family or other caregivers should also be alert to changes in your mood or symptoms.
This medication guide does not take the place of talking to your healthcare provider about your medical condition or treatment. Talk with your healthcare provider if there is something you do not understand or want to learn more about.
Do not start or stop any medicine while taking Desipramine without talking to your healthcare provider first.
Who Should Not Take Desipramine?
Do not take Desipramine if you: 1) are allergic to Desipramine or any of the ingredients in Desipramine. See the end of this section for a complete list of ingredients in Desipramine; 2) are in the acute phase of recovery from a myocardial infarction (heart attack); 3) are allergic to dibenzazepines or tricyclic drugs; 3) take a monoamine oxidase inhibitor (MAOI) or have taken an MAOI in the past 14 days. Ask your healthcare provider or pharmacist if you are not sure if you take an MAOI, including the antibiotic linezolid. Do not take an MAOI within 2 weeks of stopping Desipramine unless directed to do so by your physician. Do not start Desipramine if you stopped taking an MAOI in the last 2 weeks unless directed to do so by your physician. MAOIs include Parnate (Tranylcypromine), Nardil (Phenelzine), Emsam (Selegiline transdermal), and Marplan (Isocarboxazid).
Safety and effectiveness in the pediatric population have not been established. Do not give Desipramine to anyone younger than 18 years old without the advice of a doctor.
Before Starting Desipramine
Tell your healthcare provider about: 1) any medical conditions you have, including seizure, cardiac, liver, kidney, or blood disease; 2) current pregnancy or plans to become pregnant; 3) current breastfeeding or plans to breastfeed; 4) any and all medications and supplements you are taking; 5) any thoughts or feelings of suicide. Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.
Patients should be told that the concomitant use of Desipramine and alcohol is not advised. Patients should inform their physician if they are taking, or plan to take, any prescription or over-the-counter drugs, as there is a potential for interactions. Patients should notify their physician if they become pregnant or intend to become pregnant during therapy. Patients should notify their physician if they are breast feeding an infant. While patients may notice improvement with Desipramine therapy, they should be advised to continue therapy as directed.
Ingredients of DESIPRAMINE:
Active ingredients: Desipramine hydrochloride. Inactive ingredients: croscarmellose sodium, hypromellose, anhydrous lactose, magnesium stearate, polyethylene glycol, polysorbate 80, povidone, sodium lauryl sulfate and titanium dioxide. The 25 mg, 50 mg, 75 mg, and 100 mg tablets also contain FD&C Blue No. 1 Aluminum Lake.
Indications and Usage
Desipramine hydrochloride tablets are indicated for the treatment of depression. Off label uses include the treatment of anxiety, ADHD, cataplexy, chronic itching, bulimia, neuropathic pain, panic attacks, and depression caused by traumatic brain injury. Desipramine may also be used for purposes not listed in this medication guide. Talk to your doctor about the possible risks of using this medication for your condition.
The physician who elects to use Desipramine for extended periods should periodically re-evaluate the long-term usefulness of the drug for the individual patient.
Desipramine hydrochloride should not be given in conjunction with, or within 2 weeks of, treatment with an MAO inhibitor drug; hyperpyretic crises, severe convulsions, and death have occurred in patients taking MAO inhibitors and tricyclic antidepressants. When desipramine hydrochloride is substituted for an MAO inhibitor, at least 2 weeks should elapse between treatments. Desipramine hydrochloride should then be started cautiously and should be increased gradually.
Desipramine hydrochloride is contraindicated in the acute recovery period following myocardial infarction. It should not be used in those who have shown prior hypersensitivity to the drug. Cross-sensitivity between this and other dibenzazepines is a possibility.
Common Side Effects
Gastrointestinal: Constipation, Xerostomia
Neurologic: Dizziness, Somnolence
Ophthalmic: Blurred vision
Other: Fatigue
Serious Side Effects
Cardiovascular: Cardiac dysrhythmia, Electrocardiogram abnormal, Myocardial infarction, Myocarditis, Prolonged QT interval, Sudden cardiac death
Hematologic: Agranulocytosis, Drug-induced eosinophilia, Purpuric disorder, Thrombocytopenia
Hepatic: Hepatic necrosis, Hepatitis, Jaundice
Immunologic: Immune hypersensitivity reaction
Neurologic: Cerebrovascular accident, Neuroleptic malignant syndrome, Seizure
Psychiatric: Depression, worsening, Suicidal thoughts, Suicide
Get emergency medical help if you have any of these signs of an allergic reaction: skin rash or hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Suicidality and Antidepressant Drugs
Antidepressants increased the risk compared to placebo of suicidal thinking and behavior (suicidality) in children, adolescents, and young adults in short-term studies of major depressive disorder (MDD) and other psychiatric disorders. Anyone considering the use of desipramine hydrochloride or any other antidepressant in a child, adolescent, or young adult must balance this risk with the clinical need. Short-term studies did not show an increase in the risk of suicidality with antidepressants compared to placebo in adults beyond age 24; there was a reduction in risk with antidepressants compared to placebo in adults aged 65 and older. Depression and certain other psychiatric disorders are themselves associated with increases in the risk of suicide. Patients of all ages who are started on antidepressant therapy should be monitored appropriately and observed closely for clinical worsening, suicidality, or unusual changes in behavior. Families and caregivers should be advised of the need for close observation and communication with the prescriber. Desipramine hydrochloride is not approved for use in pediatric patients.
Patients with major depressive disorder (MDD), both adult and pediatric, may experience worsening of their depression and/or the emergence of suicidal ideation and behavior (suicidality) or unusual changes in behavior, whether or not they are taking antidepressant medications, and this risk may persist until significant remission occurs. Suicide is a known risk of depression and certain other psychiatric disorders, and these disorders themselves are the strongest predictors of suicide. There has been a long-standing concern, however, that antidepressants may have a role in inducing worsening of depression and the emergence of suicidality in certain patients during the early phases of treatment. Pooled analyses of short-term placebo-controlled trials of antidepressant drugs (SSRIs and others) showed that these drugs increase the risk of suicidal thinking and behavior (suicidality) in children, adolescents, and young adults (ages 18-24) with major depressive disorder (MDD) and other psychiatric disorders.
All patients being treated with antidepressants for any indication should be monitored appropriately and observed closely for clinical worsening, suicidality, and unusual changes in behavior, especially during the initial few months of a course of drug therapy, or at times of dose changes, either increases or decreases. Families and caregivers of patients being treated with antidepressants for major depressive disorder or other indications, both psychiatric and nonpsychiatric, should be alerted about the need to monitor patients for the emergence of agitation, irritability, unusual changes in behavior, and the other symptoms described above, as well as the emergence of suicidality, and to report such symptoms immediately to health care providers. Such monitoring should include daily observation by families and caregivers.
Extreme caution should be used when this drug is given in the following situations:
• In patients with cardiovascular disease, because of the possibility of conduction defects, arrhythmias, tachycardias, strokes, and acute myocardial infarction.
• In patients who have a family history of sudden death, cardiac dysrhythmias, or cardiac conduction disturbances
• In patients with a history of urinary retention or glaucoma, because of the anticholinergic properties of the drug.
• In patients with thyroid disease or those taking thyroid medication, because of the possibility of cardiovascular toxicity, including arrhythmias.
• In patients with a history of seizure disorder, because this drug has been shown to lower the seizure threshold. Seizures precede cardiac dysrhythmias and death in some patients.
This drug is capable of blocking the antihypertensive effect of guanethidine and similarly acting compounds. The patient should be cautioned that this drug may impair the mental and/or physical abilities required for the performance of potentially hazardous tasks such as driving a car or operating machinery. In patients who may use alcohol excessively, it should be borne in mind that the potentiation may increase the danger inherent in any suicide attempt or overdosage.
Screening Patients for Bipolar Disorder
A major depressive episode may be the initial presentation of bipolar disorder. It is generally believed (though not established in controlled trials) that treating such an episode with an antidepressant alone may increase the likelihood of precipitation of a mixed/manic episode in patients at risk for bipolar disorder. Whether any of the symptoms described above represent such a conversion is unknown. However, prior to initiating treatment with an antidepressant, patients with depressive symptoms should be adequately screened to determine if they are at risk for bipolar disorder; such screening should include a detailed psychiatric history, including a family history of suicide, bipolar disorder, and depression. It should be noted that desipramine hydrochloride is not approved for use in treating bipolar depression.
Deaths may occur from overdosage with this class of drugs. Overdose of desipramine has resulted in a higher death rate compared to overdoses of other tricyclic antidepressants. Multiple drug ingestion (including alcohol) is common in deliberate tricyclic antidepressant overdose. As the management is complex and changing, it is recommended that the physician contact a poison control center for current information on treatment. Signs and symptoms of toxicity develop rapidly after tricyclic antidepressant overdose; therefore, hospital monitoring is required as soon as possible. There is no specific antidote for desipramine overdosage. The oral median lethal dose of desipramine is 290 mg/kg in male mice and 320 mg/kg in female rats. Critical manifestations of overdose include: cardiac dysrhythmias, severe hypotension, convulsions and CNS depression, including coma. Changes in the electrocardiogram, particularly in QRS axis or width, are clinically significant indicators of tricyclic antidepressant toxicity. Early changes in the QRS complex include a widening of the terminal 40 msec with a rightward axis in the frontal plane, recognized by the presence of a terminal S wave in Lead 1 and AVL and an R wave in AVR. Other signs of overdose may include: confusion, disturbed concentration, transient visual hallucinations, dilated pupils, agitation, hyperactive reflexes, stupor, drowsiness, muscle rigidity, vomiting, hypothermia, and hyperpyrexia, among others. See the official Desipramine medication guide.
Call 911 or the Poison Help line at 1-800-222-1222 for all suspected overdose cases.
Pregnancy Category N (Not Assigned)
Safe use of desipramine hydrochloride during pregnancy and lactation has not been established; therefore, if it is to be given to pregnant patients, nursing mothers, or women of childbearing potential, the possible benefits must be weighed against the possible hazards to mother and child. Animal reproductive studies have been inconclusive.
Geriatric Use
Clinical studies of desipramine hydrochloride did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. Other reported clinical experience has not identified differences in responses between the elderly and younger patients. Lower doses are recommended for elderly patients. The ratio of 2-hydroxydesipramine to desipramine may be increased in the elderly, most likely due to decreased renal elimination with aging. This drug is known to be substantially excreted by the kidney, and the risk of toxic reactions to this drug may be greater in patients with impaired renal function. Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor renal function. Desipramine hydrochloride use in the elderly has been associated with a proneness to falling as well as confusional states.
Detailed Summary
Desipramine hydrochloride, USP is an antidepressant drug of the tricyclic type, and is chemically: 5H-Dibenz[b,f]azepine-5-propanamine,10,11-dihydro-N-methyl-, monohydrochloride. The following inactive ingredients are contained in all dosage strengths: croscarmellose sodium, hypromellose, anhydrous lactose, magnesium stearate, polyethylene glycol, polysorbate 80, povidone, sodium lauryl sulfate and titanium dioxide. The 25 mg, 50 mg, 75 mg, and 100 mg tablets also contain FD&C Blue No. 1 Aluminum Lake.
Mechanism of Action
Available evidence suggests that many depressions have a biochemical basis in the form of a relative deficiency of neurotransmitters such as norepinephrine and serotonin. Norepinephrine deficiency may be associated with relatively low urinary 3-methoxy- 4-hydroxyphenyl glycol (MHPG) levels, while serotonin deficiencies may be associated with low spinal fluid levels of 5-hydroxyindoleacetic acid. While the precise mechanism of action of the tricyclic antidepressants is unknown, a leading theory suggests that they restore normal levels of neurotransmitters by blocking the re-uptake of these substances from the synapse in the central nervous system. Evidence indicates that the secondary amine tricyclic antidepressants, including desipramine hydrochloride, may have greater activity in blocking the re-uptake of norepinephrine. Tertiary amine tricyclic antidepressants, such as amitriptyline, may have greater effect on serotonin re-uptake. Desipramine hydrochloride is not a monoamine oxidase (MAO) inhibitor and does not act primarily as a central nervous system stimulant. It has been found in some studies to have a more rapid onset of action than imipramine. Earliest therapeutic effects may occasionally be seen in 2 to 5 days, but full treatment benefit usually requires 2 to 3 weeks to obtain.
Tricyclic antidepressants, such as desipramine hydrochloride, are rapidly absorbed from the gastrointestinal tract. Tricyclic antidepressants or their metabolites are to some extent excreted through the gastric mucosa and reabsorbed from the gastrointestinal tract. Desipramine is metabolized in the liver, and approximately 70% is excreted in the urine. The rate of metabolism of tricyclic antidepressants varies widely from individual to individual, chiefly on a genetically determined basis. Up to a 36-fold difference in plasma level may be noted among individuals taking the same oral dose of desipramine. The ratio of 2-hydroxydesipramine to desipramine may be increased in the elderly, most likely due to decreased renal elimination with aging. Certain drugs, particularly the psychostimulants and the phenothiazines, increase plasma levels of concomitantly administered tricyclic antidepressants through competition for the same metabolic enzyme systems. Concurrent administration of cimetidine and tricyclic antidepressants can produce clinically significant increases in the plasma concentrations of the tricyclic antidepressants. Conversely, decreases in plasma levels of the tricyclic antidepressants have been reported upon discontinuation of cimetidine, which may result in the loss of the therapeutic efficacy of the tricyclic antidepressant. Other substances, particularly barbiturates and alcohol, induce liver enzyme activity and thereby reduce tricyclic antidepressant plasma levels. Similar effects have been reported with tobacco smoke. Research on the relationship of plasma level to therapeutic response with the tricyclic antidepressants has produced conflicting results. While some studies report no correlation, many studies cite therapeutic levels for most tricyclics in the range of 50 to 300 nanograms per milliliter. The therapeutic range is different for each tricyclic antidepressant. For desipramine, an optimal range of therapeutic plasma levels has not been established.
Drug-Drug Interactions Including P450 Interactions
The biochemical activity of the drug metabolizing isozyme cytochrome P450 2D6 (debrisoquin hydroxylase) is reduced in a subset of the Caucasian population (about 7% to 10% of Caucasians are so called "poor metabolizers"); reliable estimates of the prevalence of reduced P450 2D6 isozyme activity among Asian, African and other populations are not yet available. Poor metabolizers have higher than expected plasma concentrations of tricyclic antidepressants (TCAs) when given usual doses. Depending on the fraction of drug metabolized by P450 2D6, the increase in plasma concentration may be small, or quite large (8 fold increase in plasma AUC of the TCA).
In addition, certain drugs inhibit the activity of this isozyme and make normal metabolizers resemble poor metabolizers. An individual who is stable on a given dose of TCA may become abruptly toxic when given one of these inhibiting drugs as concomitant therapy. The drugs that inhibit cytochrome P450 2D6 include some that are not metabolized by the enzyme (quinidine; cimetidine) and many that are substrates for P450 2D6 (many other antidepressants, phenothiazines, and the Type IC antiarrhythmics propafenone and flecainide). While all the selective serotonin reuptake inhibitors (SSRIs), e.g., fluoxetine, sertraline, and paroxetine, inhibit P450 2D6, they may vary in the extent of inhibition. The extent to which SSRI-TCA interactions may pose clinical problems will depend on the degree of inhibition and the pharmacokinetics of the SSRI involved. Nevertheless, caution is indicated in the co-administration of TCAs with any of the SSRIs and also in switching from one class to the other. Of particular importance, sufficient time must elapse before initiating TCA treatment in a patient being withdrawn from fluoxetine, given the long half-life of the parent and active metabolite (at least 5 weeks may be necessary).
Concomitant use of tricyclic antidepressants with drugs that can inhibit cytochrome P450 2D6 may require lower doses than usually prescribed for either the tricyclic antidepressant or the other drug. Furthermore, whenever one of these other drugs is withdrawn from co-therapy, an increased dose of tricyclic antidepressant may be required. It is desirable to monitor TCA plasma levels whenever a TCA is going to be co-administered with another drug known to be an inhibitor of P450 2D6.
Close supervision and careful adjustment of dosage are required when this drug is given concomitantly with anticholinergic or sympathomimetic drugs. Patients should be warned that while taking this drug their response to alcoholic beverages may be exaggerated. If desipramine hydrochloride is to be combined with other psychotropic agents such as tranquilizers or sedative/hypnotics, careful consideration should be given to the pharmacology of the agents employed since the sedative effects of desipramine and benzodiazepines (e.g., chlordiazepoxide or diazepam) are additive. Both the sedative and anticholinergic effects of the major tranquilizers are also additive to those of desipramine.
Dosage and Administration
Dosage Forms and Strengths
Desipramine hydrochloride tablets, USP are supplied as follows:
• 10 mg – Each white to off-white, round, biconvex with flat edge, film-coated tablet, debossed with 341 on one side and plain on the other side. Tablets are supplied in bottles of 100 (NDC 45963-341-02) with a non-child resistant closure.
• 25 mg – Each light blue, round, biconvex with flat edge, film-coated tablet, debossed with 342 on one side and plain on the other side. Tablets are supplied in bottles of 100 (NDC 45963-342-02) with a non-child resistant closure.
• 50 mg – Each blue, round, biconvex with flat edge, film-coated tablet, debossed with 343 on one side and plain on the other side. Tablets are supplied in bottles of 100 (NDC 45963-343-02) with a non-child resistant closure.
• 75 mg – Each light blue, round, biconvex with flat edge, film-coated tablet, debossed with 344 on one side and plain on the other side. Tablets are supplied in bottles of 100 (NDC 45963-344-02) with a non-child resistant closure.
• 100 mg – Each blue, round, biconvex with flat edge, film-coated tablet, debossed with 345 on one side and plain on the other side. Tablets are supplied in bottles of 100 (NDC 45963-345-02) with a non-child resistant closure.
• 150 mg – Each white to off-white, round, biconvex with flat edge, film-coated tablet, debossed with 346 on one side and plain on the other side. Tablets are supplied in bottles of 50 (NDC 45963-346-50) with a non-child resistant closure.
Not recommended for use in children.
Lower dosages are recommended for elderly patients and adolescents. Lower dosages are also recommended for outpatients compared to hospitalized patients, who are closely supervised. Dosage should be initiated at a low level and increased according to clinical response and any evidence of intolerance. Following remission, maintenance medication may be required for a period of time and should be at the lowest dose that will maintain remission.
Usual Adult Dose
The usual adult dose is 100 to 200 mg per day. In more severely ill patients, dosage may be further increased gradually to 300 mg/day if necessary. Dosages above 300 mg/day are not recommended. Dosage should be initiated at a lower level and increased according to tolerance and clinical response. Treatment of patients requiring as much as 300 mg should generally be initiated in hospitals, where regular visits by the physician, skilled nursing care, and frequent electrocardiograms (ECGs) are available. The best available evidence of impending toxicity from very high doses of desipramine is prolongation of the QRS or QT intervals on the ECG. Prolongation of the PR interval is also significant, but less closely correlated with plasma levels. Clinical symptoms of intolerance, especially drowsiness, dizziness, and postural hypotension, should also alert the physician to the need for reduction in dosage. Initial therapy may be administered in divided doses or a single daily dose. Maintenance therapy may be given on a once-daily schedule for patient convenience and compliance.
Adolescent and Geriatric Dose
The usual adolescent and geriatric dose is 25 to 100 mg daily. Dosage should be initiated at a lower level and increased according to tolerance and clinical response to a usual maximum of 100 mg daily. In more severely ill patients, dosage may be further increased to 150 mg/day. Doses above 150 mg/day are not recommended in these age groups. Initial therapy may be administered in divided doses or a single daily dose. Maintenance therapy may be given on a once-daily schedule for patient convenience and compliance.