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California Governor Signs Law to Create First State Ethnic Studies Curriculum
California's new law requires the state's education department to create a template for an ethnic studies curriculum.
California's new law requires the state's education department to create a template for an ethnic studies curriculum.
Fifteen years after the attacks on September 11, most K-12 students have no personal memories of the event.
A Mexican-American studies textbook proposed for use in Texas schools is being criticized for its characterizations of Mexican workers.
A Cobb County teacher's lesson on slavery is the latest to draw national attention to the question of how this piece of history should be taught.
U.S. Sen. Ron Johnson, R-Wis., is apparently a fan of Ken Burns' documentary "The Civil War" and thinks they can do the job typically done by teachers.
Tennessee was part of a growing number of states that planned to require high school students to pass a civics test, but the law that actually passed looks different.
California is taking steps to implement a 2011 law that required the teaching of LGBTQ history.
How can teachers address two recent high-profile police shootings and the death of five Dallas police officers in the classroom? Here are some resources.
Wiesel, who died at age 87, wrote dozens of books, the first and perhaps most influential of which was Night, a Holocaust memoir that's taught in middle and high school classrooms around the world.
After an Advanced Placement European History curriculum revision, one critic suggests the new program doesn't focus enough on the United Kingdom.

subset: commoncrawl


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Karl Chevrolet has a wide selection of exceptional Certified pre-owned vehicles to choose from, including this 2015 Chevrolet Cruze LT. This one-owner vehicle was sold new and serviced right here at Karl Chevrolet, so we know it has been well cared for. Features include the Technology Package with Backup Camera and Bluetooth, Driver Convenience Package with Power Seat, Remote Start, Heated Mirrors, and much more! Dont miss this great value! This Chevrolet includes: SILVER ICE METALLIC LPO, ALL-WEATHER FLOOR MATS, FRONT AND REAR Floor Mats PREFERRED EQUIPMENT GROUP TRANSMISSION, 6-SPEED AUTOMATIC, ELECTRONICALLY CONTROLLED WITH OVERDRIVE (STD) A/T 6-Speed A/T CHEVROLET MYLINK Bluetooth Connection Auxiliary Audio Input Hard Disk Drive Media Storage MP3 Player JET BLACK, PREMIUM CLOTH SEAT TRIM Cloth Seats REMOTE VEHICLE STARTER SYSTEM Remote Engine Start 1LT DRIVER CONVENIENCE PACKAGE Driver Vanity Mirror Passenger Vanity Mirror Power Mirror(s) Auto-Dimming Rearview Mirror Heated Mirrors Power Driver Seat Passenger Illuminated Visor Mirror Driver Illuminated Vanity Mirror SEAT ADJUSTER, DRIVER 6-WAY POWER WITH MANUAL RECLINER Power Driver Seat EMISSIONS, CONNECTICUT, DELAWARE, MAINE, MARYLAND, MASSACHUSETTS, NEW JERSEY, NEW YORK, OREGON, PENNSYLVANIA, RHODE ISLAND, VERMONT AND WASHINGTON STATE REQUIREMENTS ENGINE, ECOTEC TURBO 1.4L VARIABLE VALVE TIMING DOHC 4-CYLINDER SEQUENTIAL MFI 4 Cylinder Engine Gasoline Fuel Turbocharged REAR VISION CAMERA Back-Up Camera MIRROR, INSIDE REARVIEW AUTO-DIMMING Auto-Dimming Rearview Mirror TECHNOLOGY PACKAGE Back-Up Camera Bluetooth Connection MP3 Player AUDIO SYSTEM, CHEVROLET MYLINK RADIO AM/FM CD Player AM/FM Stereo Bluetooth Connection MP3 Player MIRRORS, OUTSIDE HEATED, POWER-ADJUSTABLE, BODY-COLOR, MANUAL-FOLDING Power Mirror(s) Heated Mirrors SEATS, FRONT BUCKET WITH RECLINING SEATBACKS AND ADJUSTABLE HEAD RESTRAINTS Bucket Seats *Note - For third party subscriptions or services, please contact the dealer for more information.* Drive home in your new pre-owned vehicle with the knowledge you're fully backed by the CARFAX Buyback Guarantee. The CARFAX report for this 2015 Chevrolet Cruze LT highlights that it's a One-Owner vehicle, and for good reason. A One-Owner vehicle gives you the feel of owning a new vehicle without paying the new car price. As a Certified Pre-Owned vehicle, this Chevrolet Cruze LT offers you the peace of mind because you know it has been rigorously inspected to meet exacting standards. You could spend more on fuel each month than on your vehicle payments, so why not consider one with exceptional fuel economy like this 2015 Chevrolet Cruze. With complete historical records, you'll know your next pre-owned vehicle, like this one, inside and out before you purchase it. Clean interior? How about flawless. This Chevrolet Cruze looks like has never been used. More information about the 2015 Chevrolet Cruze: The 2015 Chevrolet Cruze is one of the most refined and sophisticated compact sedans on the market, offering a choice of powertrains, excellent ride comfort and top-tier safety features and amenities. The Cruze is built on a global platform and its safety performance has been tested and proven with top results in many of the world's crash-test programs - including here in the U.S. It also offers more active safety options than is typical in this class. For those who want to keep compact but use the back seat occasionally, the Cruze is particularly roomy, with a quiet, comfortable ride and some excellent connectivity with the Chevrolet MyLink. Separately, the Cruze Clean Turbo Diesel is one of the most fuel-efficient non-hybrid cars on the market with its 46-mpg highway rating. Strengths of this model include affordable pricing, Roomy interior, smooth ride, great fuel economy in ECO and Turbo Diesel variants, and excellent safety and occupant protection As always, our goal here at KARL Chevrolet is to assist you to find the perfect vehicle to meet your needs. While we strive to have the area's best selection of quality pre-owned vehicles in stock at all times, we know there are times when a customer may have very specific needs. If you have a specific model or features that you are searching for, please let us know. You might be surprised how quickly we can find a match! Just another KARL Advantage ... finding you the perfect vehicle at the best overall value. Thank you for the opportunity to assist in your vehicle search.
Price may exclude tax, title, tags, governmental fees, any emissions testing charges and any finance charges (if applicable). Unless otherwise stated separately in the vehicle details, price does not include documentation, processing, administrative, closing or similar fees. Current mileage may vary due to test drives and vehicle relocation.


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Latest News
Ex-Hearts midfielder Laryea Kingston wants to return to the club as a coach.
Kingston, 36, has received his CAF Licence B coaching certificate.
The former Ghana international is a popular figure at the club after spending two-years at the club.
And he is relishing the chance to return to the club as a coach.
"Last month I completed my License B course which means I am ready to start coaching very actively," he said.
"I want to work my way up gradually to the Premier League level.
"Everyone knows Hearts of Oak is in my heart so I will be very glad to be given the opportunity to coach or manage them one day.
"Right now I have a Division Two club I am coaching."


text: In 1991 we opened our first coffee shop in Finland and since that very day we've been serving freshly made sweets, sandwiches and drinks of highest possible quality to everyone who knocks on our door. Always with smiles on our faces, always with an open and service minded mind. Making our customers happy has been part of the Arnolds DNA since day one. Maybe that's why there are more than 30 Arnolds in Finland today (all found in city centres or in busy malls). And maybe that's why Arnolds is the most well known coffee chain in Finland. We don't know, but honestly – it makes us really proud!


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Hi loves! Today I have (finally) a new video tutorial for you! Today I'm making some easy spring flowers with the new Deborah Milano Gel Effect Spring 2015 collection! Let's take a look!
Hi girls! Today I have another tutorial for the Deborah Milano Beauty Club for you 😀 I couldn't decide what color to wear so I chose a lot of them and made a rainbow manicure. hope you like it!
Hi loves! Happy Queensday! Yeah I know, I'm one day late but I was too tired yesterday to make a blogpost. But here it is 😀


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Just blocks from Yorba Linda Country Club and walking distance to Fairmont Elementary. This Pool home is ready for a new owner. Large corner lot, with 4 bedrooms and 2.75 baths. One bedroom and bath located downstairs. Kitchen has granite counters and view of the pool. 2 fireplaces, one in living room and one in family room. This is a must see and priced right!
Listing courtesy of Julie Bruckner from Top Producers Realty & Reo
Listing courtesy of Julie Bruckner from Top Producers Realty & Reo
Based on information from California Regional Multiple Listing Service, Inc. as of . This information is for your personal, non-commercial use and may not be used for any purpose other than to identify prospective properties you may be interested in purchasing. Display of MLS data is usually deemed reliable but is NOT guaranteed accurate by the MLS. Buyers are responsible for verifying the accuracy of all information and should investigate the data themselves or retain appropriate professionals. Information from sources other than the Listing Agent may have been included in the MLS data. Unless otherwise specified in writing, Broker/Agent has not and will not verify any information obtained from other sources. The Broker/Agent providing the information contained herein may or may not have been the Listing and/or Selling Agent.


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Steiner Sports' Ben Zettler Talks Social Media Media Notes Christie Won't Replace Mike Francesa Remy Promises To Return To Booth Opening Day '18 New Docuseries Highlights Hendrick Motorsports NBA, MLB Not Expected On Turner OTT Service ESPN's "SNB" To Have Lots Of Little League Ties PGA Champ. Lowest Final Round Since '12 Turner Launching OTT Service With UEFA Content ESPN On Apple TV Allows For Four Streams On One TV
Upcoming Conferences and Events
SBD/8/Sports Media
Published May 8, 1998
Sports Illustrated's cover-story last week on professional athletes fathering out-of-wedlock children featured a young Khalid Minor, the son of Celtics G/F Greg Minor, on its cover. In Orlando, Jerry Greene calls the cover shot "cruelly exploitative." Greene: "What it illustrated was not the report but the fact that we sensationalize things today, even when we believe we're acting on this side of righteousness" (ORLANDO SENTINEL, 5/8). In K.C., Jason Whitlock, on the SI piece: "The complaints I've heard are that the issue was too personal and had nothing to do with sports, and many journalists thought SI exploited [Khalid Minor] by putting him on the cover with the headline, 'Where's Daddy?' I agree with the second complaint, but not with the first" (K.C. STAR, 5/8). CELTS RESPOND: Celtics President/coach Rick Pitino, on Minor's well-documented paternity problems: "As an organization, it is our job to counsel these players. In most of these situations, the organization has no say." On releasing Minor: "Waive him for what? For being a bad father? That's not a choice" (BOSTON GLOBE, 5/8). OSCAR CALLS STORY "OUT OF LINE": Boxer Oscar De La Hoya, who was also mentioned in the SI story, called the piece "out of line," but said that he won't take any action against the magazine (Ursula Reel, N.Y. POST, 5/8).


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Well, we're finally at camp. The trip here was relatively uneventful (except for the ice fight....ask the teens about that!) and we are settled in.
My sister, Jen, is spending the week with Camden and Josiah. You can read her blog and see what they've been up to this week. She has posted some terrific photos of my darling boys!
Please pray for our teens this week. Pray that God would speak to them, and that they would listen!


text: Terranevo is a country in the world of LUMINE. Geography and Climate Edit Terranevo is covered in snow most of the year.[1] Known Inhabitants Edit Lumine (previously) References Edit ↑ Episode 5 Retrieved from "http://lumine.wikia.com/wiki/Terranevo?oldid=453" Ad blocker interference detected! Wikia is a free-to-use site that makes money from advertising. We have a modified experience for viewers using ad blockers Wikia is not accessible if you've made further modifications. Remove the custom ad blocker rule(s) and the page will load as expected. Categories: Countries Locations Add category Cancel Save


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Please excuse, you will see at some point my eye begun to water like mad, I don't know but I kept it moving.
Jan x


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Ibanez AEG20E-TRS, steel string acoutic guitar, flamed maple top, mahogany back and sides, mahogany neck, rosewood fretboard and bridge, 20 frets, cutaway, gold Hardware, saddle width: 43mm, scale lenght: 645 mm, Fishman Sonicore pickup with Ibanez SST preamp, integrated tuner, color: transparent red sunburst, incl. gigbag and strap
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Den eksotiske træ IBANEZ AEW4012AS ER EN 12 STRING GUITAR MED ET ANGIVET ASH TOP.


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Ready Home Store: Black Forest Trifle
Ready Home Store: Black Forest Trifle
: Black Forest Trifle To change it up, try what I did and instead of cake use our Fudge Brownies ! Super Delicious! We ate it right up!
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February Workshop Recap
First and foremost, thank you. Thank you to you wonderful people who came out and joined us for our first Wind & Willow Home workshops. We had such a blast meeting you, teaching you, and learning more about your creative and business goals.
Our selling online workshop was just awesome. It was so wonderful to see the diversity in the room, from entrepreneurs who've already started out, to future entrepreneurs who have dreamed up their business and are in the process of making it real. From interactive discussion to targeted business questions, we covered a lot of ground and I had such a great time learning more about each of your ideas. In fact, this workshop was so fun that we're planning on doing a repeat class in March! (You heard it here first.) From there, we'll be diving into more focused areas of creative entrepreneurship in future workshops, including how to use Instagram and product photography. (As always, drop us a note if you have any specific requests for future workshops at firstname.lastname@example.com!)
And then our weaving workshop. We are just SWOONING over your amazing creations, each completely unique and completely yours. We can't even begin to verbalize how gorgeous your pieces are, so luckily we have some photos to help us, check out all the fun on Instagram #wwhworkshop.
Since our first weaving workshop was SOLD OUT, we wanted to give you all a chance to get in on the fun. So, by popular demand, we'd be happy to repeat this class! You can sign up here for our March Weaving Workshop in addition to our new Block Printing Workshop. In the meantime, we'll just be counting down the days until our next workshops!


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Bank Job
A cheerful, energetic, and completely entertaining movie, The Bank Job follows some small-time hoods who think they've lucked into a big-time opportunity when they learn a bank's security system will be temporarily suspended–little suspecting that they're being manipulated by government agents for their own ends. The result is that the movie doubles its pleasures: While the robbery itself has the usual suspense of a heist film, when the robbery is over the hoods find themselves being hunted by the police, the government, and brutal criminal kingpins who were storing dangerous information in a safety deposit box. The Bank Job won't win any awards, but it's enormously fun. Director Roger Donaldson (No Way Out, Species) propels the action along with vigor, editing zippily with perfect clarity among multiple storylines and various colorful characters. Jason Statham (Snatch, The Transporter), as the leader of the bank robbers, successfully steps away from his usual bone-crunching roles to a more human presence. The rest of the cast–including Saffron Burrows (Deep Blue Sea), Keeley Hawes (Tipping the Velvet), David Suchet (Poirot), and many faces familiar from British film and television–give their characters the right degree of personality and flavor without getting fussy or detracting from the headlong rush of the story. A little sex, a lot of action, a sly sense of humor, and a twisty plot; if more movies had these basic pleasures, the world would be a happier place. –Bret Fetzer


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From giant pandas to Sumatran tigers, Zoo Atlanta's large animals can have large appetites. Shuffling at least 20 pounds of plants a day to herbivores like pandas is enough of a chore, but what about large meat eaters? WABE looks into how Zoo Atlanta feeds its large carnivores.
A fossa is a weasel-like creature that climbs trees and often eats lemurs in the wild.
Feeding Zoo Atlanta's fossa, Logan, starts the way most carnivore feeding begins – with fences. Lead Carnivore Keeper Jenny Elgart says they keep humans and animals safe.
While Logan is outside in his exhibit area, Elgart sneaks a treat high up in his pen. "It's the knuckle bone of a cow, and it doesn't have a lot of meat on it. We monitor his diet pretty closely."
Then, Elgart lets in Logan through a metal door that's the zoo version of a pet flap. He scuffles in ands calls out. Since he's a tree-climber, he knows how to knock the bone to the ground for easy munching. When he's full, Logan will head back outside.
Giant Otters
For giant otters, lunchtime involves splashing. The holding building for otters Yzma and Bakairi is part pool and part concrete. They each get a bag of fish a day, and hand feeding helps with training.
Elgart stands on the other side of a fence from Yzma and holds up a fish. She explains about the otter, "She has to have good behavior, so no jumping, no vocalizing. We can target her, which means she just holds her head still … and then she gets her fish."
Elgart says encouraging animals to target like this makes it easy for keepers and vets to ensure they're healthy.
The otters also like to fish or just bring their snacks to the water. When they're done, they'll go back outside to a larger pool.
6 Spring Activities For Budding Georgian Zoologists
Sumatran Tigers
To feed the zoo's female tiger, Chelsea, Keeper Katie Gatlin walks through the cats' holding area to a fence at the back of the tiger exhibit. There, Chelsea almost seems like a house cat when Gatlin calls to the cat – and Chelsea doesn't listen.
Gatlin bribes the 250-pound tiger with milk, and the cat not only walks over, she also obeys commands. To let Gatlin check her stomach, Chelsea stands on her back paws and stretches up against the fence.
Chelsea will even put her tail through the fence so the vet can draw blood – when she feels like it.


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Hot Cayenne Pepper Vodka
Be the first to review
READY IN: 15mins
Recipe by Potatoes Browning
This is something I found in a book a few years ago, tried and loved. It gets a nice pepper taste over time. It is great for Bloody Marys or male bonding. I understand you can vary the alcohol and the pepper to whatever fits, like rum and habaneros, brandy and bird peppers. I always have a bottle in the freezer.
See Discussion:
Ingredients Nutrition
- 6 medium size cayenne chili peppers
- 1 (750 ml) bottle vodka
Directions See How It's Made
- Pour a shot or two of vodka out for yourself to compensate for the space the peppers will take.
- Cut a slit into each pepper. Remove seeds and inner tendril. Try to keep the peppers looking pretty.
- Insert each pepper into the bottle. Close bottle and store for at least 1 month if 80 proof, 3 months if 90 proof, the longer the better.


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iStockPhoto/ Thinkstock
The folks at Sealed Air recently released the results of their 2014 Food Waste Survey, and the numbers are stunning. While the global demand for food has increased exponentially as the population of developing countries skyrockets, more than a third of all the food produced in the U.S. is simply thrown in the garbage. And while Americans are increasingly aware of the issue of food waste, a shocking percentage of them refuse to admit that they're a part of the problem.


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- Wood Working Lathe Tool
- Rock Bits
- UPA-USB UPAUSB Serial Programmer Full Package V1.2 Ecu Chip Tunning Obd2 Diagnostic Tool Free Shipping FULL UPA USB PROGRAMMER
- Alloy Cnc Precision Machining Parts Coupling
- Iron Jack Plane
- Precision Micro Machining With Competitive Price
- Carbide Tipped Tool Bit T.C.T. Drill Bits
- Vertical Lathe Machine Tools C5225
- Ductile Iron Casting and Machining
Place of Origin: Hubei China (Mainland) Brand Name: Fotma Model Number: DNMG, TNMG, WNMA etc. Product Name: Carbide Tipped Tool Bit material: tungsten carbide material composition: WC, Co Material Grade: ZP25, ZP35, C2, C5 etc. Models: CNMG, DNMG,SNMM,TNMG,VNMG,RNMA,DCMT,WNMG,CCMT Surface condition: coated or un-coated application: cutting and machining Warranty: in 3 months Certificate: ISO9001 OEM: offered seajs.use(['http://style.aliunicorn.com/js/6v/biz/aisn/detail/common/quickdetail/??quickdetail.js?t=95685684_3c9a80612'], function(quickdetail){quickdetail();}); Packaging & Delivery Packaging Detail: plywood cases, paper cartons or other customized package, neutral packing available Delivery Detail: in about 25 days Specifications Carbide Tipped Tool Bit Superior quality & reasonable price 100% virgin materials Well grounded surface OEM service support. Carbide Tipped Tool Bit Our company has in its possession an advanced production line for manufacturing dies and moulds and a production line for post machined cemented carbide products. We can also supply tailor-made products of various specifications based on the requirements of our customers. Because of its high precision and high reliability, tungsten carbide inserts have been broadly used worldwide for significant productivity improvements. With different application, the inserts are sorted as wood-cutting tools, clamped inserts, milling & turning inserts, etc. 1-YG6, YG8, YG6X, YG012, YG013, YG8A etc2-CNMG, DNMG,SNMM,TNMG,VNMG,RNMA,DCMT,WNMG,CCMT Advantages of our carbide products: 1. Stable and reliable quality2. Made from 100% virgin material3. All products go through in-process and final inspection4. Free online technical service available5. Produced with advanced equipments and process6. Sample available We supply tungsten carbide wear part, tungsten carbide blanks, tungsten carbide rod, tungsten carbide plate, tungsten carbide tips, tungsten carbide drill bits, tungsten carbide saw tips, tungsten carbide tools, tungsten carbide insert, tungsten carbide blade, tungsten carbide dies, tungsten carbide products. Please contact with our sales department for more details. Carbide insert grades introduction: GradeApplicationsC2 UncoatedHigh wear resistance and high strength; machining chilled cast iron and refractory steel, finishing of normal cast iron.C5 UncoatedExcellent in strength, impact resistance and resistance to thermal shock ; Rough turning, rough planing and semi planing of Carbon steel and alloy steel.ZK10UFFine-grained alloy, good wear resistance and high strength. Semi-finishing and finishing of cast iron and nonferrous metals. It is the unique material for making of solid carbide tools for holing.ZK30UFFine grain grade. Excellent wear resistance, high in strength and impact resistance. Machining of cast irons, nonferrous metals and non-metallic materials. It is the unique material of solid carbide tools for holing. ZP25Fine in wear resistance and toughness; Rough turning, milling, planing and depth drilling of carbon steel, cast steel, manganese steel and alloy steel.ZP35A versatile grade, high in red hardness, strength and resistance to impact and thermal shocking. Roughing and strong cutting of steel and cast steel.TiN Multy Layer coating TiN/TiC/TiCN/TiN. High red hardness and excellent in wear resistance semi-finishing and finishing of steel,cast steel and alloy steel,also cast-iron and other short chip materials.TANMulty Layer coating TiC/AL2O3/TiN. Good toughness,high strength in use and versatility for roughing,medium roughing of steel,alloy steel and cast-iron, especially for high speed and quick cutting.Suggestion: We would like to recommend suitable grade depending on your machining materials. Our Products: High accuracy parts made by CNC machine with tungsten carbide inserts Our Factory: Our Office: Our Certificate: For more information about the tungsten carbide insert we supply please send us feedback. Contact Person: Cherry Zhao Skype: henrybunny Tel: +86-27-67845271 Fax:+86-27-67845262 Mobile: +86-13995656368 seajs.use(['http://style.aliunicorn.com/js/6v/biz/aisn/detail/common/richtext/??richtext.js?t=8499c9f4_59b44c0d6'], function(richtext){richtext();});Prev : Button Bits
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EC gearing, a new kind of toothed engagement — is a fundamental resource and energy saving development in the field of machine-building industry
A new kind of gearing called eccentrically cycloidal (EC) is developed,
on its basis the manufacture of almost any type of gearbox is possible
(cylindrical, planetary and bevel EC-gearboxes, and also
rack-type EC gears for mechanisms with rectilinear motion).
The new kind of gearing is asserted by 7 patents of Russian Federation.
International applications are filed.
How it works
Press about us
Technical and economic indicators
Figure shows the comparative dimensions of pinions with EC gearing and involute gearing with the same parameters (U = 9, equal loading torque).
- Several times reduction of mass and overall dimensions;
- Increased gear ratio U in one stage up to 30
(in the involute gearing U<= 8);
- It is allowed to increase misalignment and center-to-center clearance in the EC gearing 5-10 times compared with functioning standard parameters for the involute gearing without loss of force characteristics in the engagement;
- Efficiency in the EC gearing approaches the rolling efficiency 99,9% for Кfr = 0.075, since the meshing point is in the pitch point.
|By the method of investment casting, a batch of EC wheels and a gear shaft have been manufactured.
|At the exhibition "Metalworking - 2017" (Moscow) the general director of "Technology Market" CJSC Victor Stanovskoy held a number of business meetings.
|The head of the staff of the collegium of the military-industrial complex of the Russian Federation is Deputy Head of the Staff of the Government of the Russian Federation, I.V. Borovkov held a meeting in the FPI (Moscow) on EC-gearing.
|Five types of gearboxes with EC-gearing of different power and transmission ratios
|General machine building
|Reducer assembly line
|Extraction and processing of raw materials
|Reducer pumping unit
|Extraction and processing of raw materials
All projects
Look, how our technology works:


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Sewing Machine,Brass Egg Shaped Thimble Holder, This "Antique Brass Sewing Egg Shaped Thimble Holder" measures 1 and one half inches long and is 1 inch wide. This unique brass egg shaped thimble holder circa 1900 snaps shut and has a push button release to open it. This antique sewing thimble container weighs 15 grams.
Item 2330
To get the realized price, click HERE
I got a chair from my grandmother with carved dragons on it. After searching everywhere, I found the same chair on your website. I thought it looked Asian, but had no idea how valuable it is! I almost sold it to a friend for a hundred bucks. I am so glad I used your site to learn how much it's worth! Your price guide is such a great tool! Thanks Again!!
- D. Weston (customer testimonial)


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Roskamp Institute
Roskamp Institute
Sajan M.P.,Medical and Research Services |
Farese R.V.,Medical and Research Services |
Farese R.V.,Roskamp Institute |
Farese R.V.,University of South Florida
Diabetologia | Year: 2012
Aims/hypothesis We examined the role of protein kinase C-ι (PKC-ι) in mediating alterations in the abundance of enzymes in hepatocytes of type 2 diabetic humans that contribute importantly to the development of lipid and carbohydrate abnormalities in type 2 diabetes. Methods We examined (1) insulin signalling in isolated hepatocytes of non-diabetic and type 2 diabetic humans and (2) the effects of two newly developed small molecule PKC-ι inhibitors on aberrant signalling and downstream processes. Results In contrast with PKC-ι deficiency in diabetic muscle, which diminishes glucose transport, PKC-ι in diabetic hepatocytes was overproduced and overactive, basally and after insulin treatment, and, moreover, was accompanied by increased abundance of PKC-ι-dependent lipogenic, proinflammatory and gluconeogenic enzymes. Heightened PKC-ι activity most likely reflected heightened activity of IRS-2-dependent phosphatidylinositol 3-kinase (PI3K), as IRS-1 levels and IRS-1/PI3K activity were markedly diminished. Importantly, insulin-stimulated PKC-ι abundance and its overabundance in diabetic hepatocytes was reversed in vitro by both insulin deprivation and PKC-ι inhibitors; this suggested operation of an insulin-driven, feed-forward/ positive-feedback mechanism. In contrast with PKC-ι, protein kinase B (Akt2) activity and activation by insulin was diminished, apparently reflecting IRS-1 deficiency. Treatment of diabetic hepatocytes with PKC-ι/λ inhibitors diminished abundance of lipogenic, proinflammatory and gluconeogenic enzymes. Conclusions/interpretation Our findings suggest that a vicious cycle of PKC-ι overactivity and overproduction exists in hepatocytes of humans with type 2 diabetes and contributes importantly to maintaining overactivity of lipogenic, proinflammatory and gluconeogenic pathways, which underlies the lipid and carbohydrate abnormalities in type 2 diabetes.© 2012 Springer-Verlag (outside the USA).
Sheinerman K.S.,Diamir, Llc |
Tsivinsky V.G.,Diamir, Llc |
Abdullah L.,Roskamp Institute |
Crawford F.,Roskamp Institute |
Umansky S.R.,Diamir, Llc
Aging | Year: 2013
A minimally invasive test for early detection and monitoring of Alzheimer's and other neurodegenerative diseases is a highly unmet need for drug development and planning of patient care. Mild Cognitive Impairment (MCI) is a syndrome characteristic of early stages of many neurodegenerative diseases. Recently, we have identified two sets of circulating brain-enriched miRNAs, the miR-132 family (miR-128, miR-132, miR-874) normalized per miR-491-5p and the miR-134 family (miR-134, miR-323-3p, miR-382) normalized per miR-370, capable of differentiating MCI from age-matched control (AMC) with high accuracy. Here we report a biomarker validation study of the identified miRNA pairs using larger independent sets of age- and gender- matched plasma samples. The biomarker pairs detected MCI with sensitivity, specificity and overall accuracy similar to those obtained in the first study. The miR-132 family biomarkers differentiated MCI from AMC with 84%-94% sensitivity and 96%-98% specificity, and the miR-134 family biomarkers demonstrated 74%- 88% sensitivity and 80-92% specificity. When miRNAs of the same family were combined, miR-132 and miR-134 family biomarkers demonstrated 96% and 87% overall accuracy, respectively. No statistically significant differences in the biomarker concentrations in samples obtained from male and female subjects were observed for either MCI or AMC. The present study also demonstrated that the highest sensitivity and specificity are achieved with pairs of miRNAs whose concentrations in plasma are highly correlated. © Sheinerman et al.
Cui J.,Roskamp Institute |
Shen Y.,Roskamp Institute |
Li R.,Roskamp Institute
Trends in Molecular Medicine | Year: 2013
Estrogens are the primary female sex hormones and play important roles in both reproductive and non-reproductive systems. Estrogens can be synthesized in non-reproductive tissues such as liver, heart, muscle, bone and brain, and tissue-specific estrogen synthesis is consistent with a diversity of estrogen actions. In this article we review tissue and cell-specific estrogen synthesis and estrogen receptor signaling in three parts: (i) synthesis and metabolism, (ii) the distribution of estrogen receptors and signaling, and (iii) estrogen functions and related disorders, including cardiovascular diseases, osteoporosis, Alzheimer's disease (AD), and Parkinson disease (PD). This comprehensive review provides new insights into estrogens by giving a better understanding of the tissue-specific estrogen effects and their roles in various diseases. © 2012 Elsevier Ltd.
Ojo J.-O.,Roskamp Institute |
Mouzon B.,Roskamp Institute |
Greenberg M.B.,Roskamp Institute |
Bachmeier C.,Roskamp Institute |
And 2 more authors.
Journal of Neuropathology and Experimental Neurology | Year: 2013
Extensive tau-immunoreactive neurons and glial cells associated with chronic traumatic encephalopathy (CTE) have been documented in the brains of some professional athletes and others with a history of repetitive mild traumatic brain injury (r-mTBI). The neuropathology and tau involvement in mTBI have not been extensively studied in animal models, particularly in aged animals. We investigated the effects of single mTBI (s-mTBI) and r-mTBI in 18-month-old hTau mice, which express wild-type human tau isoforms on a null murine tau background (n = 3-5 per group). At this age, hTau mice already demonstrate tau pathology, but there was a significant increase in phospho-tau immunoreactivity in response to r-mTBI, but not to s-mTBI,as determined using multiple phospho-tau-specific antibodies. Repetitive mTBI also resulted in a marked increase in astrocyte/microglia activation notably in the superficial layer of the motor/somatosensory cortex and the corpus callosum. We did not observe the perivascular tau pathology, neuritic threads, or astrocytic tangles that are commonly found in human CTE. The increase in phospho-tau in the r-mTBI mice suggests that this may be a useful model for investigating further the link between mTBI, particularly r-mTBI, and tau pathobiology in CTE and in understanding responses of the aged brain to mTBI. © 2013 by the American Association of Neuropathologists, Inc.
Li R.,Roskamp Institute |
Singh M.,University of North Texas Health Science Center
Frontiers in Neuroendocrinology | Year: 2014
Studies have shown differences in specific cognitive ability domains and risk of Alzheimer's disease between the men and women at later age. However it is important to know that sex differences in cognitive function during adulthood may have their basis in both organizational effects, i.e., occurring as early as during the neuronal development period, as well as in activational effects, where the influence of the sex steroids influence brain function in adulthood. Further, the rate of cognitive decline with aging is also different between the sexes. Understanding the biology of sex differences in cognitive function will not only provide insight into Alzheimer's disease prevention, but also is integral to the development of personalized, gender-specific medicine. This review draws on epidemiological, translational, clinical, and basic science studies to assess the impact of sex differences in cognitive function from young to old, and examines the effects of sex hormone treatments on Alzheimer's disease in men and women. © 2014 Elsevier Inc.
Farese R.V.,University of South Florida |
Sajan M.P.,Roskamp Institute
American Journal of Physiology - Endocrinology and Metabolism | Year: 2010
Atypical protein kinase C (aPKC) isoforms mediate insulin effects on glucose transport in muscle and adipose tissues and lipid synthesis in liver and support other metabolic processes, expression of enzymes needed for islet insulin secretion and hepatic glucose production/release, CNS appetite suppression, and inflammatory responses. In muscle, selective aPKC deficiency impairs glucose uptake and produces insulin resistance and hyperinsulinemia, which, by activating hepatic aPKC, provokes inordinate increases in lipid synthesis and produces typical "metabolic syndrome" features. In contrast, hepatic aPKC deficiency diminishes lipid synthesis and protects against metabolic syndrome features. Unfortunately, aPKC is deficient in muscle but paradoxically conserved in liver in obesity and type 2 diabetes mellitus; this combination is particularly problematic because it promotes lipid and carbohydrate abnormalities. Accordingly, metabolic effects of aPKCs can be "good" or "bad," depending upon nutritional status; thus, muscle glucose uptake, islet insulin secretion, hepatic glucose and lipid production/release, and adipose fat synthesis/ storage would be important for survival during periods of limited food availability and therefore be "good." However, during times of food surfeit, excessive activation of hepatic aPKC, whether caused by overnutrition or impairments in extrahepatic effects of insulin, would lead to inordinate increases in hepatic lipid synthesis and metabolic syndrome features and therefore be "bad." In keeping with these ideas, the inhibition of hepatic aPKC markedly ameliorates lipid and carbohydrate abnormalities in experimental models of obesity and type 2 diabetes. We postulate that a similar approach may be useful for treating humans.
Li R.,Roskamp Institute |
Shen Y.,Roskamp Institute
Life Sciences | Year: 2013
The study of specific target protein expression is often performed by western blotting, a commonly used method to measure the protein expression in neuroscience research by specific antibodies. Housekeeping proteins are used as an internal control for protein loading as well as reference in the western blotting analysis. This practice is based on the belief that such housekeeping genes are considered to be ubiquitously and constitutively expressed in every tissue and produce the minimal essential transcripts necessary for normal cellular function. The most commonly used housekeeping proteins are β-actin, β-tubulin, and glyceraldehyde 3-phosphate dehydrogenase (GAPDH). However, recent studies have shown significant variation in some housekeeping genes both at the mRNA and protein levels in various neuropathological events, such as spinal cord injury and Alzheimer's diseases. Changes of housekeeping genes are also induced by non-neuronal diseases in various tissues. Therefore, these discoveries raise a potential concern regarding whether using a housekeeping protein as an internal standard for target protein analysis is an appropriate practice. This minireview will focus on (I) the effects of neuronal and non-neuronal diseases, experimental condition, and tissue-specific roles on alteration of housekeeping genes, and (II) alternative internal standards for gene and protein expression analysis. © 2013 Elsevier Inc.
Laco G.S.,Roskamp Institute
Biochimie | Year: 2015
A key target in the treatment of HIV-1/AIDS has been the viral protease. Here we first studied in silico the evolution of protease resistance. Primary active site resistance mutations were found to weaken interactions between protease and both inhibitor and substrate P4-P4′ residues. We next studied the effects of secondary resistance mutations, often distant from the active site, on protease binding to inhibitors and substrates. Those secondary mutations contributed to the rise of multi-drug resistance while also enhancing viral replicative capacity. Here many secondary resistance mutations were found in the HIV-1 protease substrate-grooves, one on each face of the symmetrical protease dimer. The protease active site binds substrate P4-P4′ residues, while the substrate-groove allows the protease to bind residues P12-P5/P5′-P12′, for a total of twenty-four residues. The substrate-groove secondary resistance mutations were found to compensate for the loss of interactions between the inhibitor resistant protease active site and substrate P4-P4′ residues, due to primary resistance mutations, by increasing interactions with substrate P12-P5/P5′-P12′ residues. In vitro experiments demonstrated that a multi-drug resistant protease with substrate-groove resistance mutations was slower than wild-type protease in cleaving a peptide substrate, which did not allow for substrate-groove interactions, while it had similar activity as wild-type protease when using a Gag polyprotein in which cleavage-site P12-P5/P5′-P12′ residues could be bound by the protease substrate-grooves. When the Gag MA/CA cleavage site P12-P5/P5′-P12′ residues were mutated the multi-drug resistant protease cleaved the mutant Gag significantly slower, indicating the importance of the protease S-grooves in binding to substrate. © 2015 Elsevier B.V. and Société Française de Biochimie et Biologie Moléculaire (SFBBM). Al1 rights reserved.
Li R.,Roskamp Institute |
Cui J.,Roskamp Institute |
Shen Y.,Roskamp Institute
Molecular and Cellular Endocrinology | Year: 2014
Estrogens can be synthesized in non-reproductive tissues such as liver, heart, muscle, bone and the brain. During the past decade, increasing evidence suggests that brain estrogen can not only be synthesized by neurons, but also by astrocytes. Brain estrogen also works locally at the site of synthesis in paracrine and/or intracrine fashion to maintain important tissue-specific functions. Here, we will focus on the biology of brain estrogen and its impact on cognitive function and Alzheimer's disease. This comprehensive review provides new insights into brain estrogens by presenting a better understanding of the tissue-specific estrogen effects and their roles in healthy ageing and cognitive function. © 2014 Elsevier Ireland Ltd.
Li R.,Roskamp Institute
Journal of Sport and Health Science | Year: 2014
The differences of learning and memory between males and females have been well documented and confirmed by both human and animal studies. The sex differences in cognition started from early stage of neuronal development and last through entire lifespan. The major biological basis of the gender-dependent cognitive activity includes two major components: sex hormone and sex-related characteristics, such as sex-determining region of the Y chromosome (SRY) protein. However, the knowledge of how much biology of sex contributes to normal cognitive function and elite athletes in various sports are still pretty limited. In this review, we will be focusing on sex differences in spatial learning and memory - especially the role of male- and female-type cognitive behaviors in sports. © 2014 Shanghai University of Sport.


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For the second year in a row, cremations have been more popular than burials in the United States. more...
August 21 , 1959 : Hawaii became the 50th state to enter the Union. more...
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A lumbar laminectomy is a type of spinal surgery which is designed to relieve pressure on the spinal column and nerves. This procedure is also known as an open decompression. Like other surgical procedures, a lumbar laminectomy comes with some definite risks, but the procedure can be highly effective in treating leg pain and gait problems caused by problems in the spinal canal, making it worth it for some patients. Some surgeons have a success rate as high as 80%, which can be significant for patients who are suffering from extreme pain.
This procedure is necessitated by degenerative spinal conditions which cause a buildup of pressure along the spinal canal. The spinal canal itself may be impinged upon by bone spurs and a narrowing of the spaces between the vertebrae, and the nerves exiting the spinal column can also be pinched between the vertebrae. A lumbar laminectomy will usually be recommended after noninvasive treatment methods have failed.
In the surgery, the doctor makes an incision in the lower back, approaching the spine and stripping muscles away from the area as he or she works. Once the spinal column is exposed, the vertebrae in the area of concern are very carefully trimmed, with the doctor removing soft tissue, bone spurs, and sometimes parts of the vertebrae as well to relieve pressure. In some cases, the surgeon may need to install pins or screws to stabilize the spine. Next, the incision is closed, and the patient is brought out of anesthesia.
Patients should expect to stay in the hospital for around three days after a lumbar laminectomy. They are encouraged to walk and engage in gentle physical therapy during the healing stages, but heavy lifting and twisting are not advised, since these activities can tear at the site of the surgical incision. If the surgery is a success, the patient should have significantly reduced leg and back pain, with the laminectomy procedure being most successful in the treatment of leg pain.
Any time someone goes under anesthesia, there are risks due to the potential for adverse reactions to anesthesia. These risks are greatly reduced by working with a skilled surgical team, but they should be considered when patients decide whether or not to get a lumbar laminectomy. A surgeon should be comfortable discussing specific risks with a patient before the surgery takes place. Spinal surgery also carries some risk, including permanent nerve damage, infection, and paralysis. It is a good idea to ask for a surgeon's record and to confirm that he or she is board certified prior to the surgery.
Post 1
How is the space created by removal of muscle replaced when the wound is closed?
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