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Lisa 🐝 Gallagher23/06/2017A Message from North Korea by a 24 Year old GirlThis video speaks for itself. What can we do to help? This is powerful and devastating. ...
Comments24/06/2017 #5 David B. GrinbergLisa, thank you for sharing this a powerful and moving message from such a brave young woman about the perpetual string of atrocities and injustices which continue to plague the people of North Korea by a totalitarian regime run by an evil incarnate. The reckless disregard of the regime for the basic human and civil rights of the people is indeed alarming. Unfortunately, the USA's strategic military options are not good.
If we attack the hermit nation by land, air and sea, their million man army will initially overwhelm the 20,000+ US troops protecting South Korea along the DMZ. The N. Korean military would send missiles into Soul which is very close to the border and is densely packed with millions of S. Korean citizens. Yes, the USA would ultimately prevail through sheer military might. But the toll of lives lost would be devastating. Thus, there appear to be no good options other than an internal coup to oust the ruthless regime and dispose of the despot. Let's hope and pray for the best.24/06/2017 #4 Lisa 🐝 Gallagher#3 First they'd be driven to the Tumen River. But when it came time to leave, Black was afraid they'd be too conspicuous in a car and insisted that they instead walk through the mountains to the crossing point, a seven-hour ordeal that permanently damaged the nerves in his toes.
The video Brian- speculation on his behalf. He backed nothing up with fact. So, her story changed, she was a victim of horrible abuse. She was young and still is.
I don't care, we all know that N. Korea is guilty of 100 of thousands of Human rights abuses, not to mention murder.
Otto Warmbier, 22, who was arrested in North Korea while visiting as a tourist, had been described by doctors caring for him last week as having extensive brain damage that left him in a state of "unresponsive wakefulness." (For taking a poster off the wall??!!!) https://www.reuters.com/article/us-usa-northkorea-detainee-idUSKBN19A2TW23/06/2017 #3 Brian McKenzieShe works for a South Korean 'Freedom Think Tank" funded by .... wait for it....
PS -- A compass doesn't fail to work. GPS - yes - compass - no. It only 'stops working' if it is crushed. Magnets, Science.
Facts over Feels.23/06/2017 #2 Brian McKenziePandering, petulant Wag the Dog
Here we fkn go again23/06/2017 #1 Brian McKenzieNot this shit again. EVERY time these globalist f*cks trot out a crying girl on cam, they launch a new little war. Lousy Elitist, blood thirsty miscreants. Look for war in the zone before the Olympics. Nice going. 8?/
Veronica Ochoa27/04/2017#ALEXANDRA BELL #MIKE BROWN #POLITICAL ART #RESIST #NYLON #counternarrative #responsiblejournalism #bias #racism #copywriting #editorsnoteThis Public Art Project Makes A Powerful Statement About "Fake News"www.nylon.com We talk with artist Alexandra...
Veronica Ochoa17/04/2017#syria #AbdAlkaderHabak This photo will define this war. It will be like the #napalmgirl of the #vietnamwar and so many other brave photographs of horrible international wars and of dehumanizing violence. I just came back from hiking and I read this article. I am reminded of this passage from the Qu'ran "And the servants of the Most Merciful are those who walk upon the earth easily, and when the ignorant address them [harshly], they say [words of] peace," Surah:25: verse 63www.elmundo.es Se llama Abd Alkader Habak y trabaja como reportero gráfico en Alepo, la mayor ciudad de Siria, escenario este sábado de un atentado contra un convoy de evacuados que dejó más de...
Veronica Ochoa12/04/2017#mansplaining101 #whiteprivilege #thefutureisfemale Very proud of my native Minnesotan female congressional representatives for refusing to sign a law or pass a law which would inhibit political dissent. Rena Moran you walk the walk and talk the talk. #renamoranMinnesota Legislator Who Called Out White Male Colleagues Won't Apologize | The Huffington Postwww.huffingtonpost.com "I'm really tired of watching women of color, in particular, being ignored," said state Rep. Melissa...
Veronica Ochoa10/04/2017#PlannedParenthood #mybodymyrights #handsoffmyvagina #handsoffmyuterus #stopregulatingwomensbodies
For those not aware in the US right now, handguns are LESS regulated than women's reproductive organs, bodies and reproductive rights.
#merica #7inchesforplannedparenhood So, glad to see a list of A-lister musicians putting forth their own music to support all womyn. #plannedparenthood #intersectionalfeminist7-inches for Planned Parenthoodthecreativeindependent.com Brandon Stosuy, TCI Editor-in-Chief and Creative Director for 7-Inches For Planned Parenthood, provides context on the the project's genesis and collaborative...
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Mohammed A. Jawad01/02/2017The Value of a HugA refugee's hug* The world looks on as the United States of America appears to be in self destruction mode. One day it was a world leader of hope, justice, truth, liberty and many positives. The next it was everything we have been taught to dislike...
Comments04/02/2017 #10 Sushmita Thakare JainThank You @Donna-Luisa Eversley for tagging me in, I wonder how I had missed on this post
I agree with you, on taking stand for the Right.
Your poem is so warming and heart touching.
For me its simple no religon supports violance and those who support it belong to no religion.
We all the Children of the almighty and we need to be treated with equality.
Sending you Hugs my friend 😘😇04/02/2017 #9 Donna-Luisa Eversley@Sushmita Thakare Jain ..fyi03/02/2017 #8 🐝 Fatima G. WilliamsMe toooo Hugs you @Donna-Luisa Eversley Donna Girl :)03/02/2017 #7 Cyndi wilkinsUnfortunately, what the current president of our USA does not understand is that the remedy to terrorism is not hostility toward the already hostile...It's like taking a stick and whacking mindlessly at a BEES nest...(Pardon the pun)...This is no laughing matter for any of us...especially those of us who despise the very thought of enduring the next four years with a schoolyard bully pushing the vulnerable to the ground and expecting everyone to cheer...The ones that do are the fearful...and no border wall will ever be high enough to "repeal and replace" genuine understanding;-) This is a beautiful poem @Donna-Luisa Eversley...It gives me hope for humanity;-)02/02/2017 #6 Franci🐝Eugenia Hoffman, beBee Brand AmbassadorSending hugs your way, @Donna-Luisa Eversley. 💐💐02/02/2017 #5 CityVP 🐝 ManjitFrom my personal experience, the world's premier hugs are in Brazil. Get working in Brazil, spend about 3 years and on returning everything will be fine. Escalation when it is a deliberate political strategy can't work when people are too busy focused on hugs.01/02/2017 #4 Pascal DerrienHugs are useful to help un-manufacturing hate :-)01/02/2017 #3 Donna-Luisa Eversley#2 @Mohammed A. Jawad wow thank you for sharing such a real and apt poem . Wealth is temporary as is our lives. I ish everyone reads your comment. Thank you01/02/2017 #2 Mohammed A. JawadAh, where stands the worth of this little globe, our world, in the vastness of the whole Universe. And the true master of this whole, expansive Universe is the Almighty Lord, and we humans, in this world, are just helpless, weak with temporal stay. Yet, with little power and dusty wealth, how man becomes prodigal, egoistic, arrogant, and marches forth to conquer the world and make others under oppression. Here's, one of my poems, I wish to post here:
In the business of living—
how well are men compounded
Nothing best, yet brief reflections
of mingled realities and distress
With an overflow of chronicles sad
there's an imprint of misery
Let some gracious celestial powers descend
to check the beggared lives and
move the blameworthy souls.01/02/2017 #1 Donna-Luisa EversleyThis post has generated 1.9m views in a couple as a repost, and decided to publish on beBee to ensure the message is easily accessible! Peace & love
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Pamela 🐝 Williams29/01/2017Where Have You Been? Over the last couple of weeks I have heard that question in my head. I'm not hearing voices but my sometimes overactive imagination could hear my fellow Bees asking me why my presence on beBee has been infrequent of late. It had nothing...
Comments19/06/2017 #58 Pamela 🐝 Williams#57 Hi Martin, yes it's been months, I could make excuses but quite frankly, it's all been a head journey. If I can thank the buffoon in DC for one thing it's that it has opened my eyes, made me question my own life. I'm actually doing very very well but thank you for checking in!14/06/2017 #57 Martin WrightPamela, its been months , where have ypu been and are ypu alright?27/02/2017 #56 Preston 🐝 Vander Ven#55 Thank you for your update to my question.27/02/2017 #55 Pamela 🐝 Williams#54 Preston, I understand your confusion. It was originally supposed to be a march about women's issues, but with the political roller coaster that is occurring and the numerous policy issues that were dividing the country the women's march became much much more. In our own march the name was officially changed to the Human Rights, Justice, & Equality March. The originators of the march in DC followed this same train of thought as I understand from the speech one of the organizers gave. It's because all these issues are women's issues. LGBT rights are women's issues, equality, immigration, justice; they are all women's issues, so they came together. I'm sorry those in St Louis had disagreements because it was supposed to be inclusive and tolerant; that was the whole point. Otherwise there wouldn't have been men marching right beside us! Fathers carrying their young daughters on their shoulders with signs that read; I march for my little girl. Or Christian mother's marching beside their gay sons and daughters with signs that read; equality includes everyone or God loves my gay son too (yes I saw these signs). It was a moving day Preston and one I will never forget.27/02/2017 #54 Preston 🐝 Vander VenI think it was the same weekend in St. Louis that there was a women march. I was working at an Autoshow. There were a lot of supporters and I was very happy for everyone marching and peacefully using their First Amendment Rights. What I didn't like was at the women march in St. Louis was there was no common theme. Even on the Metro Train, even though women were wearing the same shirts, they were all marching for different causes. One group next to me was pro-life trying to support Trump, one group of women was talking about equal rights but wouldn't speak on which rights of women needed to be solved, the next group was only their to try to bring back Hillary, a fourth group was marching for Men who want to act like women to have the rights of women, then I saw another group protesting the national security issues. I watch about ten minutes of the women getting together, yet their was a lot are disagreement among the groups. Certain women said they other women where not allowed to be at this march. So, What was the main theme of this march?31/01/2017 #53 Mohammed A. JawadThought-provoking post @Pamela 🐝 Williams. Here's one of my poems...enjoy it!
Worldly Disputes
By the uses of faith and reason
let men judge their plain folly
There's nothing in worldly disputes
but flaws of untruth, precepts of idiocy
And, more trouble in the periods of existence
that pays regard to mistaken subjects
Lo! its an outbreak of idle deeds
which oft shadows common sense.31/01/2017 #52 Lisa 🐝 GallagherI'm working on organizing, not "I"31/01/2017 #51 Lisa 🐝 GallagherThis needs more traffic, one of the most important topics affecting not only the US but the globe right now. I working on organizing. My daughter in law is attending a March in Denver this week for Muslims.29/01/2017 #50 Suzanne Dwillies-Khan, Pharmacist and MusicianThank-you for sharing and posting :)29/01/2017 #49 Pamela 🐝 Williams#48 Thank you for the kind compliment Franci and for reading my post.29/01/2017 #48 Franci🐝Eugenia Hoffman, beBee Brand AmbassadorWell written piece and thank you for voicing your opinions, Pam. I am glad you are feeling better.29/01/2017 #47 Pamela 🐝 Williams#43 Oops, accidentally deleted my reply:
What is coming out is that the efforts to put him into the wh began in prior to 2010, and then Congress became GOP dominant. They used the media and the Tea Party to feed into the people's frustrations and turn it into irrational anger. You hear this negativity every day for 6 years and it seeps into your pores. They laid their groundwork well and that is why he felt confident in making that statement, even though I think it shook a few people in the party.
The thing about such a campaign is they know it will be easy to punch holes in that dam and that is the reason for the drastic measures they are taking now, and the campaign to clamp down on the media. If they can turn this country into a military state quickly then we may see the largest 'democracy' fall. I don't think they were counting on The Resistance and so they are getting careless...They made a huge mistake; that the American people would stay gullible. They are losing support daily and the pressure is being put on the rest of the party. If they don't get the 'control' they are aiming for by mid-term elections they know they will have lost the war...It will be the next 22 months that will speak volumes. IMHO29/01/2017 #45 Pamela 🐝 Williams#44 And/or mid-term elections and we clean out Congress!29/01/2017 #44 CityVP 🐝 ManjitOnly 207 more weeks to go - unless their is an impeachment or an insurrection.29/01/2017 #43 CityVP 🐝 Manjit#6 Trump did not just slip through he boasted vocally that he was slipping through. One of his campaign boasts was that if he had shot someone in the street, his supporters would still vote for him. http://thehill.com/blogs/ballot-box/gop-primaries/266809-trump-i-could-shoot-people-in-streets-and-not-lose-support29/01/2017 #42 Deb 🐝 Helfrich#29 @Pamela 🐝 Williams - that is a crucial topic for discussion. The knee-jerk, bullying sentiment that 'if you don't love the US as it is right now, you are a communist' that aims to silence clear, rational discussions by making someone feel "wrong".
That specific tendency - the extreme polarization of any idea or opinion - is exactly part of the malaise that has changed us from a country of messy, flawed, but essential tolerance to one of intolerance in around 3 or 4 decades.
The communism trope is simply deployed to stop someone from continuing the initial point they were making.
We need clarity so profoundly right now. That is the way forward.29/01/2017 #41 🐝 Fatima G. Williams#35 I wish it worked that way after they become leaders. But I've not seen such a leader for the people in my life so far 🤐🙁😟😟😟
@Pamela 🐝 Williams That's lovely to know about Greensboro I feel more closer to them now and I wish you guys all the best. Praying for the best 😘29/01/2017 #40 Jared 🐝 Wiese ➡ I sell YOU. Fast!Seth Godin: The tribes we lead
https://www.ted.com/talks/seth_godin_on_the_tribes_we_lead/transcript?language=en29/01/2017 #39 Jared 🐝 Wiese ➡ I sell YOU. Fast!#32 Why do people vote against their own interests?!
https://www.google.com/search?q=people+vote+against+own+interests29/01/2017 #38 Jared 🐝 Wiese ➡ I sell YOU. Fast!#28
"I've realized that our community is a global community". Perhaps it's more than just our community...
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Pascal Derrien27/01/2017Human One Point O Have you heard about the Mars One Project `` Mars One plans to establish the first human settlement on Mars by April 2023? The first crew of four astronauts emigrate to their new planet from Earth, a journey that takes seven months. A new team will...
Comments02/02/2017 #29 Pascal Derrien#28 thanks @Neil Smith indeed indeed ....... :-(02/02/2017 #28 Neil Smith#23 In fact Pascal I would say that "common sense" is a long way from being all that common.29/01/2017 #27 Aleta Curry#26 I see the system stripped out my HTML and that last sentence didn't make a great deal of sense. It's supposed to have a < / rant >, but you all get the idea!29/01/2017 #26 Pascal Derrien#25 thanks @Aleta Curry :-) what else can I say now :-)29/01/2017 #25 Aleta CurryWhat an eerily-evocative photograph!
See, just reading the opening paragraph, there I was all ready to start with my 'stop with the cosmic gaseous emission pollution and leave people who are bigger and badder than we are alone ain't you people ever heard of The Borg?' spiel. But this isn't about that. before it's begun! :D
Thanks for another thought-provoking piece, @Pascal Derrien.28/01/2017 #24 CityVP 🐝 Manjit#22 The Martian's would welcome us because we will arrive with solutions to overcome their global warming issue, it is the Venusian's that they are dead scared of. They did not even try to explore Earth or Mars before global warming turned Venus into a brimstone planet. http://www.dailygalaxy.com/my_weblog/2014/06/-venus-and-mars-hold-priceless-climate-change-warnings-for-earth-todays-most-popular.html
Alas the Martians are no more, so Mars is simply the planetary equivalent of early settlement Australia, we can place all the personal branding people that Douglas N. Adams once designed the B-Ark for. This time we will keep the prisoners though as prison workers.
B-Ark - Douglas Adams - Hitchhikers Guide to the Galaxy
https://www.youtube.com/watch?v=CSid-p0Xlk028/01/2017 #23 Pascal Derrien#20 that would make sense @Donna-Luisa Eversley but common sense is a devalued currency at the moment :-)28/01/2017 #22 Pascal Derrien#21 thanks @CityVP 🐝 Manjit history is full of those examples indeed, a few good individuals always give hope and light but is it enough to warrant us a mandate to disturb the martians :-)28/01/2017 #21 CityVP 🐝 ManjitHuman beings in jam jars - that is actually where civilization is in terms of how evolved it really is. The good news is that we are still evolving, the bad news is that it is not fast enough. The most amazing people are those who invited refugee's into their own homes - but that is the road lesser traveled. We only know where we are on this issue, when the territory is our own home. Empathy at our own individual door step has a different face than when a government takes responsibility for it. Remember Bablyon was in Iraq and the Rastafarians keep singing about the fate of Bablyon as a allegory for the United States. Empires rise, empires fall. We don't need to go to Mars, for the way humanity is proceeding, it seems they want Earth to look like Mars.28/01/2017 #20 Donna-Luisa EversleyMaybe humans need to figure out how to live together on earth before taking a self destructive journey elsewhere. Hmm... Good mental stimulation @Pascal Derrien28/01/2017 #19 Lisa 🐝 Gallagher#12 Well said Pascal! I hope our Congress grows a set, they are going to need to stand up in a bipartisan manner to this Prez.28/01/2017 #17 Pascal Derrien#3 Indeed @Franci🐝Eugenia Hoffman, beBee Brand Ambassador the comment was right on the button , thank you for saying so. :-)28/01/2017 #16 Pascal Derrien#4 @Max🐝 J. Carter Europe is not homogeneous in its views and obviously culture that makes it difficult and exciting at the same time :-)28/01/2017 #15 Pascal Derrien#5 thanks @Dean Owen I am trying to park (if feasible) the political aspect and focus on the people aspect of the mass exodus, on Germany and o her countries I think we enough boats to rescue most from this morale titanic fiasco :-(28/01/2017 #14 Pascal Derrien#6 @Ken Boddie , Bob knew a few things, I think we know them too but we aren't learning :-(28/01/2017 #13 Pascal Derrien#7 exactly @Chas ✌ Wyatt what an interesting paradox I thought too :-)28/01/2017 #12 Pascal Derrien#8 the new US admin will be tested very soon beyond the bravado when reality will impose it self on the policy makers, isolationism will need nowhere @Lisa 🐝 Gallagher28/01/2017 #11 Pascal Derrien#10 @Aurorasa Sima, Germany has shown leadership and humanity at a time of great crisis, now they getting the flack from the populists and Pediga but it was the right thing to do in my opinion they set the bar for the other countries28/01/2017 #9 Lisa 🐝 GallagherI forget to add the link from where I drew the info/stats in my comment below: http://time.com/4116619/syrian-refugees-screening-process/28/01/2017 #8 Lisa 🐝 GallagherThis *Was* the US policy for refugees- Among those who pass background checks, a small percentage are referred for overseas resettlement based on criteria designed to determine the most vulnerable cases. This group may include survivors of torture, victims of sexual violence, targets of political persecution, the medically needy, families with multiple children and a female head of household. How long does the whole process take?
Eighteen to 24 months on average.
So even after the torture, rape and more it still takes up to 2 yrs for the process to be completed. Now, we have a new Prez who just put a halt on helping those who will probably die if they don't get refuge in another country.
If there is a God, it would be 'one world,' not 'Countries' that are defined by borders, distance and Men.
José Ramón 🐝 López01/12/2016
Comments01/12/2016 #1 Mauricio Castro NavarreteGod bless all the children in Aleppo. My absolute admiration for all of them.
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Dr. Allen Brown02/07/2016What are Human RightsAt the conclusion of our last broadcast on Grassroots Talks Radio show I was moved by one our co-host Selim as we talked about the topic of betrayal. While it started of focusing on relationships the discussion turned to being betrayed by the boss...
Comments24/07/2016 #13 Margaret Aranda, MD, PhD#9 #10 Great wisdom to know that the value and extent of education for your child(ren) rests on you, the parent. It is so simple to say, yet it screams from the school bells that have now turned into buzzers and gongs.05/07/2016 #12 Selim Yeniçeri#9 #10 One of my mentors had said once "You talk too much. You have too ears, but one mouth. God tells you to speak once, listen twice." I took these words to the heart, and became a lifelong learner. You're right, William. I wish parents would be so sensitive about this. Unfortunately, most of them leave the education of their kids to the schools.05/07/2016 #9 William VanDorin#6 If only more parents had the same attitude and mental attributes this would be a very different world.. Once the thirst for knowledge is introduced, you will spend the rest of your life drinking parched from the cup. It only takes the right spark like my friend Selim.05/07/2016 #6 Selim Yeniçeri#5 One of the most common lies in my country is that "people have been uneducated and made ignorant." Education is "one of the" government's responsibilities, but "main responsibility" of the individuals. I grew up in the same country, and people call me "The Walking Library," because nobody stopped me from reading, searching, exploring, and learning. My son goes to school, but as his father, it's me who is responsible for his education foremost, not his teachers. And if those teachers are somehow wrong about something, I would emphasize it, too! When I was teaching English classes, my students (and they were adults, not kids or teens) would ask me "Can we talk English as good as you do?" I would always come up with the same answer: "If you don't want to learn, nobody can teach you. If you do, you will learn despite me!"03/07/2016 #5 William VanDorin#3 I wish I were wrong in most sincerity, but do not feel this is the nature of the majority. I truly believe we are being manipulated by our leadership creating divisive issues in race, sex and religion to name a few. Unfortunately the skills to do so are well honed and most good people do not anticipate treachery. There is simply no greater villain than those who would divide us in hatred and mistrust. We really can not blame our leadership or media, as they would have no power if we failed to follow. There is a better way, we must simply step off the path and hate no more.02/07/2016 #3 William VanDorinHuman rights is the fair, ethical and humane treatment of individuals regardless of sex, religion or race. It is a myth of course. An ideal we aspire to as a culture, but as a species we do not act upon. The proportion of our resources devoted to destruction and hatred demonstrates this truth all to clearly..02/07/2016 #2 Dale Masters@Dr. Allen Brown Sadly enough, our God-given rights are being flushed down the toilet as an excuse for keeping us safe. Meanwhile, police departments are being given weapons that, Constitutionally, they never should have had in the first place. Because no one is taught how to think critically, the public still swallows the 9/11 lie, despite experts like Architects and Engineers for 9/11 Truth and Pilots for 9/11 Truth having a plethora of evidence that the whole story around 9/11 was fabricated. We live in a country that is rapidly taking on the aspects of the State that Orwell mentioned in "1984". Books are being removed from library shelves (for example) that were written during WWII...because (I suspect) they challenge some of the most basic ideas about Hitler's actions vis-a-vis Poland among other things, like Hitler's peace treaty with Great Britain . When all the books of that era are finally gone, and the people who fought in the War are dead, the State is free to rewrite history to its liking. This is but one example of the evil being perpetrated against the American people and the rest of the world.02/07/2016 #1 Lisa 🐝 GallagherPowerful message in the video @Dr. Allen Brown! I hope more people see this.
Francisco Lopez23/06/2016This 17 year old kid, and an Irish Citizen, is for the last three years in a one meter by one meter cell in an Egyptian prison. and in a legal limbo. He was arrested while taking refuge in a Mosque while accompanying a group of teens to watch a protest. His sitesrs were freed but he remains in prison.Ibrahim Hawala's Storywww.linkedin.com It was the summer of 2013; A summer for one 17-year-old boy named Ibrahim Hawala that could easily be called the summer of hell. Ibrahim is an Irish citizen by birth, both his parents are...
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Brian McKenzie14/06/2016Social Justice 'Equality'That word equality is in quotes because it is another vacant idea that is great for stirring up a herd of prattle cattle without respect to numbers, facts, critical examination or reality; and instead relies only upon low information Pavlovian...
Comments13/07/2016 #13 Brian McKenzie#12 Actually that twerk was for free - while I was waiting for the burgers to grill up and somewhere between the 3 & 4 spiked Kvas / Vodka drink.....no money was earned. Sorry IRS. viva la wage gap.13/07/2016 #12 Jim MurrayYou're much sexier than and Kardashian. Phil Friedman and I were chatting last night and wondered= if we were the only two guys left who prefer to not kiss some sort of ass in our posts. And here you are workin' the poll for dolla bills. Good post. Politicians are all full of crap. Except Bernie Sanders...he's like half full. I'm personally exhausted from all the electioneering going on other there. But it's like train wreck. It's awful, but you just can't look away. I'm going to go hide in my basement now cause it's Africa hot outside and it's still cool down there.15/06/2016 #11 Brian McKenzieno, HER data is consistent with my argument - that when you remove the hyperbole of Social Justice and look at specific industries and account with education levels, experience, and time in position - the difference between salaries is most often accounted for my the differentiation of overtime hours vs short shift hours and not a function of gender discrimination. There is no statistically viable wage gap. Data doesn't support it - Market performance doesn't show it. And if you READ my article, and WATCHED the videos - that is the argument I made throughout. Trot out those industries that Goldin is adamant about - and I will let math settle the issue; because that is what math does.15/06/2016 #10 Michele Williams#9 @Brian McKenzie. Thank you for the data. I agree with your point about pharmacy. In the statement that I quoted, Goldin was indeed praising pharmacy as one of the few industries with a linear relationship between pay and hours worked. This holds for men and women. She was explaining some of the technological advances that have made this possible. Your data are consistent with her arguments about pharmacy. Goldin's data also suggest that many industries do not have this linear relationship between hours worked and pay.14/06/2016 #9 Brian McKenzie#8 Women in pharmacy are 53% of the work force market sector according to 2011 census date, in the same sampling period women in the field received a median pay of 111,000 for the profession - 92% of the wage of men in the same sector - In an article from CNN Money - GOLDIN states "Women with children earn less largely because they work fewer hours, source citation: http://cnnmon.ie/237AcBr The article further highlights - "there is a small gap, but it can be almost entirely explained by some men working longer hours - - not discrimination." Economics is not Sociology - Sociology surely is not Economics. They are not interchangeable because of 'feels' - numbers, statistics, reporting quantifiers and market practice don't give credence to the rant.14/06/2016 #8 Michele Williams#5 As we consider women with and without children in the workplace, the question becomes one for sociologists. Why is work organized in a way that provides large differentials for more consecutive hours in the office and does it need to be that way? I met with Claudia Goldin last year, from that conversation and her AEA address, I believe that she discusses how some firms and occupations organize work to create a linear relationship between consecutive hours worked and pay, which benefits people who value flexibility (see the quote from Goldin below). I think it is best to let all bees view her speech, download her papers and decide for themselves. @Brian Mckenzie, we may have to agree to disagree.
GOLDIN: … My favorite example is pharmacy, in which there's virtually no part-time penalty, in which there is very little ownership now in terms of independent pharmacies. …So, there have been changes in pharmacy that have led pharmacists to be better substitutes for each other — the use of highly standardized drugs, for example, less compounding, less individual, less need for a particular pharmacist to deal with you. Information technologies have been absolutely essential. When you go to the pharmacist, it could be any of the pharmacists working there who are intelligent and professional and can read the information about you. So some of what has happened that has been good for women comes from changes that I call organic, and they simply happen because of various technological advances that make each pharmacist a perfect puzzle piece for another pharmacist. And also, I mean, go to Silicon Valley and they don't talk about family time, they talk about play time, and it's work-life balance rather than just work-family balance."14/06/2016 #7 Lori BoxerOne word: Bravo.14/06/2016 #5 Brian McKenzie#4 @Michele Williams Goldin agrees with Anne-Marie Slaughter; in that 'If you take women who don't have care-giving obligations, they're almost equal with men. It's somewhere in the 95 percent range. But when women then have children, or again are caring for their own parents or other sick family members who need care, then they need to work differently.' She terms it "Temporal Flexibility". In that if you compare same and similar family status workers; between the genders - there is minimal statistical difference between pay, by her account 5% by BLS numbers 3% : It is when women leave the work force to have children, or reduce their hours to care for aging parents while the man increases his hours and accumulates overtime that the 'gap' appears.
Damn Math. * source http://bit.ly/1Rs87RZ The answer - is if you want to be wealthy and get ahead in the labor force - don't get married, don't have kids - and trust me; the men of MGTOW are all too aware of that paradigm - it is why we are not getting married, and certainly not breeding mini-mes14/06/2016 #4 Michele Williams#2 @Brian Mckenzie I understand and share your frustration over the flawed statistical analysis of the gender pay gap that enflames people's emotions. However, that does not change the fact that rigorous research in economics, research that controls for education, experience, age and industry, for instance, finds a persistent gender pay gap. The gap is smaller than the overall averages reported in the media, but significant and persistent across most industries. I would recommend the highly rigorous and respected work by two award-winning economists, Claudia Goldin, a chaired professor of economics at Harvard University and Francine Blau, a chaired professor of economics at Cornell University. The gender pay gap is not an issue for radical feminists alone; it is an issue for human beings, men and women, who care about a social structure that is unequal and want their daughters to be paid fairly.14/06/2016 #3 George HullI agree with your point of view @Brian McKenzie radical feminists complain so much about wages or legal natters being unfair, but as you are going to write an article about it, I don't see any woman complaining about the rights they are awarded with when there's a divorce.14/06/2016 #2 Brian McKenzieI have had my fill of Social Justice Warrior shit - I am done with it. They will bring emotions and feels to an argument that requires math, statistics, economics and hard number analysis - they never survive the evidence; not once, not yet.
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Mohammed A. Jawad08/05/2016Hapless Destinies of Darling DaughtersIf one wishes to pen down the essence and worth of daughters, then much can be written. Indeed, there's a popular dictum that says 'birth of a daughter is both blessing and mercy'.Verily, there's a unique merit in girl's existence, and as she grows...
Comments08/05/2016 #3 Mohammed A. Jawad#2 That's so painful to hear from you. Keep patience, and encourage your dear daughter to strengthen her spirit and be cheery. After hardship, there's always ease...08/05/2016 #2 Suzan ChamberlainI agree. My own precious daughter entered an oppressive marriage and was horribly mistreated by her husband and his parents. It happened right here in the US. It's a tragedy no matter what country you live in or what religion you belong to. She is lost to me and my heart breaks everyday. I miss her so much. In my eyes and heart she is and always will be my precious little girl.


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Conceived and designed the experiments: AM AJS SR. Performed the experiments: AM CHN. Analyzed the data: AM. Contributed reagents/materials/analysis tools: AM WD AC AJS SR. Wrote the paper: AM AJS. Edited the paper: SR, AJS.
Assessment of molecular defects that underlie cognitive deficits observed in mendelian disorders provides a unique opportunity to identify key regulators of human cognition. Congenital Myotonic Dystrophy 1 (cDM1), a multi-system disorder is characterized by both cognitive deficits and a spectrum of behavioral abnormalities, which include visuo-spatial memory deficits, anxiety and apathy. Decreased levels of DMPK (Dystrophia Myotonica-protein kinase), SIX5, a transcription factor or MBNL1 (Muscleblind-like 1), an RNA splice regulator have been demonstrated to contribute to distinct features of cDM1. Mouse strains in which either Dmpk, Six5 or Mbnl1 are inactivated were therefore studied to determine the relative contribution of each gene to these cognitive functions. The open field and elevated plus maze tasks were used to examine anxiety, sucrose consumption was used to assess motivation, whereas the water maze and context fear conditioning were used to examine spatial learning and memory. Cognitive and behavioral abnormalities were observed only in Mbnl1 deficient mice, which demonstrate behavior consistent with motivational deficits in the Morris water maze, a complex visuo-spatial task and in the sucrose consumption test for anhedonia. All three models of cDM1 exhibit normal spatial learning and memory. These data identify MBNL1 as a potential regulator of emotional state with decreased MBNL1 levels underlying the motivational deficits observed in cDM1.
Myotonic dystrophy (DM1) is a multi-system disorder characterized by muscle weakness, skeletal myotonia, cardiac conduction defects, ocular cataracts and cognitive and behavioral abnormalities [1]. DM1 is caused by a CTG repeat expansion found in the 3′UTR of the DMPK gene and located immediately 5′ of the SIX5 gene on chromosome 19 [2], [3], [4], [5]. Repeat expansion results in three distinct molecular defects that increase in severity as a function of repeat tract length: first, as consequence of the aberrant sequestration of the mutant DMPK RNA within the nucleus, DMPK levels are decreased in DM1 cells [6], [7]. Second, CTG repeat expansion results in the transcriptional down-regulation of the linked SIX5 allele leading to diminished levels of SIX5 [8], [9]. Third, expression of expanded CUG repeat sequences have been shown to dysregulate RNA splicing due to the inactivation of the alternative splice regulator, MBNL1, by mechanisms that have yet to be fully understood [10], [11], [12], [13], [14], [15]. The pleiotropy of the DM1 phenotypes are thought to result from a combination of these three effects, with the expression of CUG repeats playing a prominent role in the development of major aspects of the disease.
Patients with the myotonic dystrophy type 1 exhibit cognitive and behavioral abnormalities including mental retardation, visuo-spatial memory deficits, apathy, anxiety, hypersomnolence, autism, depression and attention deficit hyperactivity disorders [16], [17], [18], [19], [20]. Patient assessment suggests that apathy cannot be accounted for by depression or muscle weakness and reflects a CNS involvement [17]. It is also of interest to note that visuo-spatial reasoning and memory appears to be specifically compromised in DM1 patients [16]. The severity of psychiatric illness in DM1 is roughly proportional both to the CTG tract length and age of disease onset with cognitive and behavioral deficits showing the greatest prevalance and severity in the congenital form of the disorder [21].
To investigate the contribution of these genes to cognitive symptoms observed in DM1 patients, we studied the effect of deletion of Six5, Dmpk and Mbnl1 on three separate behavioral tasks designed to test learning and memory, anxiety and motivation. These three mouse models of DM1 show various physical phenotypes pertaining to myotonic dystrophy. Dmpk−/− mice display muscle weakness and heart disease [22], [23], Six5−/− mice display cataracts and heart disease [24], [25] and Mbnl1−/− mice display skeletal myotonia, muscle weakness, cataracts and possibly heart disease [15]. Therefore, we carefully chose tasks that require varying degrees of muscular strength (i.e. low demands in fear conditioning, higher demands in the water maze) and performed control tasks when possible (i.e. visible watermaze to control for the hidden water maze) in order to dissociate muscular/physical impairments from higher level brain functional deficits. Our results demonstrate that neither Six5 nor DmpK affect cognitive function but that Mbnl1−/− mice have deficits consistent with decreased motivation.
We began by assessing anxiety-related behaviors (thigmotaxis or wall-hugging) and general activity using the Open Field task. In this task, mice are placed in an open arena and allowed to explore. No differences in Open Field thigmotaxis (wall-hugging, Figure 1i), ambulation (total cm traveled, Figure 1ii) or average velocity (cm/s, Figure 1iii) were detected in the Six5−/− and Dmpk−/− mutant mice compared to their wild-type littermate controls (Figure 1A, and B, respectively). However, Mbnl1−/− mice showed increased thigmotaxis, and decreased ambulation and average velocity (Figure 1C). These results show that Mbnl1−/− mice have decreased overall activity experience. Increased thigmotaxis exhibited by the Mbnl1−/− mice could be due to muscle weakness, increased anxiety or decreased motivation to explore.
Since Mbnl1−/− mice showed increased thigmotaxis, but the cause of this anxiety-related behavior is unclear, we further tested these mutants in the elevated plus maze, another anxiety test. Mice are placed on a 4-arm maze in which two arms are sheltered and the other two arms are open. This configuration presents a "safe" environment in the sheltered, darker arms and a more "dangerous" environment in the two open, lighted arms. Similar to the open field task, mice that are anxious will spend more time in the "safe", closed arms.
The Mbnl1−/− mice generally show normal anxiety levels in this test. They did not show a preference for the closed arms, spending the same amount of time in the open and closed arms as well as the center of the maze (Figure 2A, I, ii and iii, respectively). Although not statistically significant, the Mbnl1−/− mice spend slightly more time in the open arms compared to their wild-type littermates. Similarly, the Mbnl1−/− mice spent less time in the stretch position which is typically indicative of decreased anxiety (Figure 2B). Lastly, Mbnl1−/− mice show the same relative number of entries into the closed and open arms, although the total number of entries are decreased (Figure 2C, i, ii and iii, respectively). However, Mbnl1−/− mice also made fewer head dips over the side of the maze, which normally indicates increased anxiety (Figure 2D).
As with the open field test, the observed behavior may have contributions from decreased motivational drive to explore, muscular phenotypes or altered anxiety. Indeed, Mbnl1−/− mice have decreased locomotion in the elevated plus maze, making significantly fewer total entries and entries into the closed arms. Although the Mbnl1−/− mice also entered the open arms fewer times than their wild-type littermates, this was not statistically significant, probably due to the low number of entries by both the wild-type and Mbnl1−/− groups of mice (Figure 2C, iii). Overall, these results indicate that the musculoskeletal deficits in the Mbnl1−/− mice lead to poor performance on the elevated plus maze, and result in conflicting indicators of anxiety, namely fewer head dips and less time in the stretch position. Given these results, it is likely that their musculoskeletal phenotype is contributing to poor performance on the elevated plus maze and thus cannot be directly interpreted. Taken together with the Open Field phenotype, these results are inconclusive as to whether or not the Mbnl1−/− mice experience increased anxiety and but do indicate that the mutant mice have musculoskeletal deficits.
To investigate hippocampal cognitive function, we tested these three DM1 models in contextual fear conditioning. This is a hippocampus-dependent task that measures formation of predictive associations. In context fear conditioning, mice are placed in a training chamber, allowed to explore and subsequently given a mild foot shock. In this paradigm, the mouse learns that the specific context predicts the foot shock and will exhibit fear responses such as freezing (lack of all movement except for breathing) when returned to the same context.
Six5−/−, Dmpk−/− and Mbnl1−/− mice show no deficits in hippocampus-dependent context fear conditioning (Figure 3Ai, Bi and Ci, respectively). Both freezing (Figure 3A) and activity suppression (the relative decrease in locomotor activity of post-training to pre-training levels, Figure 3B) in a test performed 7 days after training were normal compared to wild-type littermate controls. Activity suppression normalizes for general activity levels of the mice and therefore corrects for potential hypo- and hyper-activity [26].
Although hippocampus-dependent associative conditioning was normal in all three DM1 disease models, abnormal baseline activity and activity bursts (the response to the foot shock which includes jumping and/or running) were observed in Mbnl1−/− mice. Specifically, both Six5−/− and Dmpk−/− mice displayed normal baseline activity (pre-traininig locomotor activity, Figure 3Aiii and Biii, respectively) and foot shock response (Figure 3Aiv and Biv). In contrast, the Mbnl1−/− mice display hypo-activity (Figure 3Ciii) and a decreased response to foot shock (activity burst, Figure 3Diii), consistent with muscle weakness or myotonia.
To further examine hippocampal function as it relates to visuo-spatial learning and memory, we performed the Morris water maze task. In this task, mice are trained daily to find a hidden platform in a circular pool, using external spatial cues to create a map of the environment and assist in navigation. The Water Maze has non-spatial components such as swim velocity, latency or pathlength during acquisition and thigmotaxis as well as spatial components, such as spatially-selective search strategies during probe trials in which the hidden platform is removed [27]. Mice were given two training trials per day, with probe trials given both during acquisition and at the end of training.
Both the Six5−/− (Figure 4A) and Dmpk−/− (Figure 4B) mutant strains showed normal acquisition as defined by the latency to find the platform (Figure 4i), had normal swim speeds (Figure 4ii), and normal levels of thigmotaxis (Figure 4iii). Mbnl1−/− mice also improved with time, acquiring the task whether measured as latency (Figure 4Ci) or pathlength to find the platform (Figure 4Ci inset). However, we observed several deficits in the Mbnl1−/− mice, including decreased swim speeds and increased levels of thigmotaxis (Figure 4Cii and iii, respectively). A number of Mbnl1−/− mice exhibited >10% thigmotaxis by the end of training so were excluded from these analyses (Figure 4C and D). If these mice are included, the Mbnl1−/− mice show the same swim speed but even greater thigmotaxis (Figure S1A). These data are consistent with decreased muscle strength observed in the Mbnl1−/− mice [15].
Interestingly, as training proceeded, Mbnl1−/− mice spent more time "floating" (% time floating, Figure 4D). This represents an inability to switch from a passive strategy to a spatially selective strategy and is typically indicative of decreased motivation [27]. This phenotype was not observed in either the Six5−/− or Dmpk−/− mice (data not shown). This is unlikely to be caused by muscular fatigue or myotonia for the following reasons. First, the Mbnl1−/− mice perform normally in the visible watermaze (Figure 4E) which involved three sequential trials compared to two sequential trials in the hidden platform task, and was performed after the hidden watermaze. Consequently, if the Mbnl1−/− mice were fatigued, this should be more evident in the visible watermaze. Second, myotonia exhibits a "practice effect" meaning that the failure of muscle relaxation after contraction decreases with even a short warm-up period of activity [28]. Importantly, this phenotype was not observed at the beginning of training but only manifested after probe trials in which the hidden platform is removed. Thus, these factors are consistent with the hypothesis that the Mbnl1−/− mice "give up" when the task is too difficult, suggesting motivational deficits instead of muscular fatigue or weakness.
Six5−/−, Dmpk−/− and Mbnl1−/− mutant mice showed normal spatial learning and memory, searching selectively for the platform (Figure 5A, B, and C respectively). If, however, spatial learning and memory is assessed with the inclusion of the Mbnl1−/− mutant mice that exhibited high levels of thigmotaxis at the end of training, they showed a deficit in spatial memory, randomly searching for the platform in all quadrants (% time in target quadrant Figure S1D). Importantly, Mbnl1−/− mutant mice had normal acquisition when trained in the visible water maze task which is marked by a local cue and has the same physical requirements but involves different cognitive capacities (Figure 5E and Figure S1C). Therefore, the visible water maze controls for performance indicating that the decrease spatial ability in the Mbnl1−/− mice is not due to decreased vision from cataracts, or muscular complications such as myotonia, decreased skeletal muscle strength or cardiac complications.
The performance of the Mbnl1−/− mice in the watermaze suggested that these mutants may have motivational deficits. To directly test apathy in these mutants, we chose a task that has minimal physical requirements. The sucrose consumption test, a classic anhedonia test, presents the mouse with a two bottle choice, one bottle contains water and the other contains a solution of sucrose. During habituation, Mbnl1−/− mice drank the same amount of water as their wild-type controls (Figure 6A). However, Mbnl1−/− mice showed no preference for sucrose compared to the wild-type mice for 2%, 4% and 8% sucrose (Figure 6B). Given a large enough reward of 16% sucrose, Mbnl1−/− mice showed a increased consumption of sucrose, drinking a similar volume of sucrose as their wild-type littermates (Figure 6B). The Mbnl1−/− mice showed a lack of interest in sucrose, a behavior typical of decreased motivation.
Patients with myotonic dystrophy have numerous physical symptoms, including musclular, skeletal, cardiac and vision difficulties. It has been long realized that they experience cognitive impairment, with a lower IQ overall and specific deficits in attention, visuo-spatial function, perception, executive function and autism spectrum disorder symptoms [16] [29] [17] [19] [20]. Apathy, hypersomnia and anxiety have been more recently associated with myotonic dystrophy and are dissociable from the physical disabilities. They appear to be explicit symptoms of the disease, and like the physical symptoms, there is a correlation with the severity of disease and cognitive deficits in which less severely affected patients generally have milder cognitive deficits.
The pleiotropy of this disease is reflected in symptoms, their severity and the molecular alterations that occurs. The disease is caused by a trinucleotide repeat expansion situated in the 3′UTR of the DMPK gene, located immediately 5′ of the SIX5 gene but the core of the biochemical defect is sequestration of MBNL1 by the expanded trinucleotide repeat RNA in nuclear foci. RNA processing is disrupted, in part due to inactivation of the alternative splice regulator, MBNL1 which normally regulates splicing of several transcripts including Cncl1, a chloride channel associated with myotonia [30] [15]. This RNA-dominant disease consequently has many possible molecular alterations that lead to individual symptoms. Therefore, it is important to ascertain which molecular alteration leads to the cognitive and emotional deficits seen in DM1 patients.
Neither Six5−/− nor Dmpk−/− mice appear to affect cognitive function in mouse models of DM1. In DM1, a trinucleotide repeat is expanded and disrupts normal RNA processing in the nucleus, and sequestering Mbnl1 protein in specific foci. Since in both Six5−/− and Dmpk−/− mice, there is no trinucleotide repeat, these mutants can be used to differentiate between the direct effect of a gene and the effect of impairing the function of other proteins with which they interact. Supporting the hypothesis that RNA metabolic disruption is key to the development of DM1 symptoms, we found deficits only in the Mbnl1−/− mice. Mbnl1−/− mice have normal spatial learning and memory but show severe alterations in motivated behavior. Specifically, Mbnl1−/− mice showed signs of motivation and apathy in a physically demanding task (Morris water maze) or a simple task (sucrose consumption).
Due to their physical symptoms, the cognitive and emotional phenotype of the Mbnl1−/− mice is difficult to assess. However, Mbnl1−/− mice show unmotivated behavior in the water maze, failing to switch from passive strategies to a spatially selective search as exhibited by increased floating in the watermaze task [27]. Interestingly, this increased floating only manifested after probe trials were performed. Combining this observation with normal performance in the visual watermaze suggests a complex interaction between the difficulty of the task and a substantial motivational component that underlie their lack of spatial acquisition, with the possibility that muscular weakness also contributes to apathy. Thus, Mbnl1−/− mice may become unmotivated if they fail to learn the platform location expediently. A number of Mbnl1−/− mice also exhibited such pronounced thigmotaxis that they were excluded from final analysis. The remaining Mbnl1−/− mice showed normal spatial learning and memory when tested without the platform present, however, the Mbnl1−/− mice that demonstrated pronounced thigmotaxis did not show any spatial learning and memory. This demonstrates that Mbnl1 deficit in these mice results in a range of severity of the observed phenotypes.
To substantiate a phenotype of decreased motivation, we tested Mbnl1−/− mice for apathy towards sucrose. The mice were tested in their home cage with the sucrose and water bottles presented in their normal location. Therefore, physical complications of this task are minimal as the physical demands are the same as drinking water in their home cage: these mutants do not experience dehydration from an inability to reach the water bottle. In this test for anhedonia, Mbnl1−/− mice show preference for sucrose over water at a much reduced rate than their wild-type counterparts. The Mbnl1−/− mice appear to require a higher reward as a 16% solution was equally appealing to the Mbnl1−/− mice as a 4% solution was to the wild-type mice. This suggests that the mutant mice do not have an innate aversion to sucrose but instead that they have a decreased interest in seeking a sweet reward. This finding may be particularly relevant as apathy is a striking feature in myotonic dystrophy patients and has been shown to be independent of both clinical depression and peripheral muscular weakness [17].
In addition to lack of motivation, myotonic dystrophy patients have increased anxiety. We tested all three mutant mouse strains for alterations in anxiety levels and only Mbnl1−/− mice exhibited high levels of thigmotaxis, a behavior indicative of anxiety. Although Dmpk−/− and Six5−/− showed no overt anxiety phenotype in the open field, we performed only one test of anxiety and thus subtle phenotypes may exist that can be detected using other tests. In a second test of anxiety, the elevated plus maze, the Mbnl1−/− mice showed conflicting signs of increased and decreased anxiety. Given these ambiguous results, it is difficult to determine if these mice are good models of anxiety observed in myotonic dystrophy patients. Furthermore, it would be difficult to determine the basis for their altered performance in either the open field and elevated plus maze tasks. The underlying cause of altered performance could be decreased motivation to explore, increased anxiety or musculoskeletal effect, or a combination of all three factors, all three of which are consistent with the human disease.
Finally, contextual associative learning was normal in the Mbnl1−/− mice. Since DM patients do not show remote memory deficits, we did not test memory at later times. Specifical alterations in 24-hour memory consolidated and remote memory were not tested however, based on a normal memory phenotype at seven days, which is it is indicative of protein-synthesis dependent memory and the transition to a remote memory [31], [32], we speculate that all three mutant strains will show relatively normal memory at these times as well. Taken together, these data suggest a normal spatial learning, with a complex motivational alteration that may result in part through an interaction of muscular effects with emotional state in Mbnl1−/− mice.
Important questions to address in the future will be to assess motivational drive in Mbnl1−/− mice with normal musculoskeletal function. Since these are separable in patients with DM1, it is likely that the transcripts controlled by Mbnl1 processing may play a specific role in apathy and motivation. The specific transcripts that undergo altered splicing due to Mbnl1 are not all known. Deep sequencing of the different mutant models of DM1 will be very useful in generating and further refining genotype/phenotype relationships. Mbnl1 belongs to a three-member family, and the role of specific Mbnl family members may further refine our understanding of the transcriptional misregulation that leads to specific symptoms [33]. The lack of these specific phenotypes in the Dmpk−/− and Six5−/− mice suggests that these genes do not play a role in motivation when they are specifically deleted but their dysfunction, as caused by the DM1 trinucleotide repeat expansion, may still participate in generating cognitive effects in patients. Defining the specific regions of the brain that show functional impairment in Mbln1 knockout mice and identification of Mbnl1 target RNAs in these areas will be critical to understanding this complex phenotype. These lines of inquiry should allow key insights into the molecular targets and circuits that regulate motivation, and spatial learning and memory in humans.
All experiments were performed in accordance with the institutional guidelines of the University of California at Los Angeles. For all tasks, male and female mice in the 129B6 genetic background were generated from heterozygous matings and all tests used mutant mice with their respective wild type littermates as controls. All mice were group-housed, maintained in a 1212 light/dark cycle and had food and water ad libitum. Six5−/−, Dmpk−/−, and Mbnl1−/− mice have been previously described [15], [22], [23], [24], [25]. All mice were tested between the ages of 8–14 months, Six5−/− mice ranged from 8–12 months, Dmpk−/− mice were 8–10 months and Mbnl1−/− mice were 8–14 months at the time of testing. Mice were used for multiple tests in this order: open field, watermaze, fear conditioning or open field, elevated plus maze, sucrose consumption, watermaze with a minimum of two weeks rest before commencing a new test.
Since physical deficits are present, we looked at specific measures during the behavioral tasks to minimize the influence of these impairments.
Open Field activity, the first behavioral test performed, was assessed to examine generalized activity and thigmotaxis (wall-hugging). Animals were placed in an open 30.5 cm by 30.5 cm space and allowed to explore for ten minutes under dim light conditions. Horizontal locomotor acivity was measured as beam breaks by paired sets of photo beams using the Activity Monitor systems (Med Associates, St. Albans, Vt). We measured thigmotaxis (amount of time in the outer versus inner zone), and general activity levels (velocity and total distance travelled). For the Six5 mutant strain, 6 wild-type and 7 mutant mice were tested. For the Dmpk mutant strain, 9 wild-type and 9 mutant mice were tested. For the Mbnl1 mutant strain, 23 wild-type and 19 mutant mice were tested.
In the elevated plus maze, a second anxiety test, mice were placed in the center of a four-arm maze and their movement on the maze was recorded for five minutes in dim light. The maze was 60 cm off the floor. Two arms were sheltered with 16.5 cm opaque walls and the other two arms were open. We measured the amount of time in the closed and open arms and the center of the maze, as well as the number of entries into each arm. The time in a stretch approach position and the number of times the mice dipped their heads over the edge of the maze was also scored. We tested 14 wild-type and 14 Mbnl1−/− mice.
Mice were trained in context fear conditioning. Animals were placed in the training chamber during which time baseline activity and freezing levels were obtained, followed by a single shock, delivered at 4 minutes. After seven days, mice were returned to the training chamber and tested for long-term memory of the context by measuring activity and freezing levels. Context fear conditioning was performed as previously described [31] using Med Associated Mouse Context Conditioning boxes. Automated freezing, activity scores and activity suppression ratios [(test activity)/(test activity + baseline activity)] were calculated as previously described [26]. Six wild-type and 6 Six5−/− mice, 10 wild-type and 6 Dmpk−/− mice, and 12 wild-type and 5 Mbnl1−/− mice were tested in this task.
Morris Water Maze training was commenced to examine spatial learning and memory of the mutant mice, as previously described [34]. Briefly, animals are trained to locate a hidden submerged platform in a pool filled with opaque water. Probe trials, used to assess spatial memory by examining the search pattern of the mice when the platform was removed, were administered on days 5, 7, 9 for Dmpk−/−, days 4 and 7 for Six5−/− and days 4, 7, 10 and 13 for Mbnl1−/− mice. Results for the last probe trial are shown. Pathlengths to find the hidden platform during acquisition were used in addition to latency as latencies can be influenced by slow swim speeds. Upon completion of the hidden Water Maze task, all mice were tested in the visible water maze using a single session with three training trials in which the location of the submerged platform is marked by a local cue. This test further controls for performance, including visual capabilities and muscle deficits. Mbnl1−/− mice were analysed in two groups, data shown excludes individual mice that showed >10% thigmotaxis at the end of training as these mice may have visual complications that affect distant vision. Analysis of all Mbnl1−/−mice is shown in the supplemental data. For the Dmpk mutant strain, we tested 10 wild- type and 6 mutant mice, which were trained with two trials per day. For the Six5 mutant strain, we tested 13 wild-type and 12 mutant mice with two trials per day with probe trials on days 4 and 7. For the Mbnl1 mutant strain, we tested 25 wild type and 21 mutant mice with two trials per day with probe trials. Analysis of Mbnl1−/− mice was performed both excluding and including mice that exhibited more than 10% thigmotaxis at the end of training. This resulted in exclusion of 1 wild type and 8 Mbnl1−/− mice.
Mice were tested for motivation/anhedonia using the sucrose consumption test. Animals were water restricted overnight on each day of habituation and testing. Mice were habituated to testing cages with two drinking spouts, both of which contained water after which, one solution was replaced with sucrose. Mice were given 2%, 4%, 8% and 16% sucrose for three days each, the first day was used as habituation to the new solution. The volume of either water or sucrose was averaged for the remaining two days, in which the presentation of water and sucrose was counterbalanced. Fourteen wild-type and 14 Mbnl1−/− mice were tested.
The following software was used for analysis of raw data: Open Activity from Med Associates for the Open Field, custom designed software for fear conditioning described [26] and HVS Image for the water maze. All other behavioral data was obtained by hand-scoring. ANOVA was used to compare genotypes in the Open Field (thigmotaxis, velocity and ambulation), Water Maze (thigmotaxis and velocity), and Fear Conditioning (% freezing and suppression ratio for baseline and 7 day test, and activity). Repeated Measures ANOVA was used to compare genotypes in the Water Maze (acquisition latency or pathlength, % floating, visible Water Maze latency, and % time in target quadrant), and Fear Conditioning (activity bursts). All error bars represent standard error of the mean.
Mbnl1−/− mutant mice have altered performance in the Morris Water Maze. All mice, including Mbnl1−/− mice that demonstrate pronounced thigmotaxis are included. A) No statistical differences were found in the latency (seconds) to find the platform during training (panel i) (effect of genotype x latency using 2-day blocks, repeated measures ANOVA, F(6,264)=1.29, p=0.26) for Mbnl1−/− mice (white, n=21) compared to their Mbnl1+/+ wild-type littermate controls (black, n=25). A inset: The pathlength (m) to reach the target platform of Mbnl1−/− (white) was significantly different during acquisition compared to Mbnl1+/+ mice (black) (effect of genotype x latency F(6,264)=2.81, p=0.012; main effect of genotype F(1.44)=7.43, p=0.0092). Mbnl1−/− mutant mice (white) had a slower average velocity during all training days (cm/s, panel ii) (F(1,43)=52.7, p=<0.0001) and increased thigmotaxis (% time, panel iii) (F(1,43)=12.2, p=0.0011) compared to their wild-type littermate controls, Mbnl+/+ mice (black). B) The % time spent swimming slowly (floating behavior) of Mbnl1−/− (white) increased compared to Mbnl1+/+ mice (black) during acquisition (F(1,44)=16.4, p=0.0002; effect of genotype x latency F(6,264)=5.25, p=<0.0001) (panel i). Mbnl1−/− mice showed increased floating behavior in all training blocks except block 3. C) Mbnl1−/− mice displayed normal acquisition in the visible water maze task (pathlength (m), (effect of genotype x pathlength using 2-day blocks, repeated measures ANOVA, F(2,86)=0.694, p=0.50)). Training blocks represent two days (4 training trials) for Mbnl1 mutant mice. D) The percent time spent in the Target Quadrant (TQ), Adjacent Left (AL), Adjacent Right (AR) or Opposite Quadrant (OP) is shown. A score of 25% reflects random searching. Probe test results after training are shown. Statistically significant differences were found in the percent time spent in searching in each quadrant on day 13 as shown for wild-type (black) and Mbnl1−/− (white) mice (genotype x quadrant, repeated measures ANOVA F(3,132)=5.66, p=0.0011), main effect of genotype (F(1,44)=0.041, p=0.84). The Mbnl1−/− mice spent significantly less time searching in the target quadrant (F(1,44)=7.48, p=0.0089) and more time in the opposite quadrant (F=(1,44)=8.84,p=0.0048).
The authors would like to acknowledge Dr. Maurice Swanson for his generous gift of all the mutant mouse strains.
Competing Interests: The authors have declared that no competing interests exist.
Funding: This work was supported by grants from the Muscular Dystrophy Association and the NIH (RO1 NS 050861) to SR, and from the NIMH (P50-MH0779720) to AJS. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.

subset: commoncrawl


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Pelham, NY Dance Lessons
Looking for private in-home or in-studio Dance classes? Our Pelham teachers are ready to get you started. Find your teacher today!
Our online tools make booking, managing your schedule and paying for lessons easy and hassle-free.
Easily search and compare teachers in your area, including past student reviews and background checks.
If you're not completely satisfied, we'll help you find a new teacher or refund any unused lesson credits.
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Our teachers have taught
lessons and counting!
Popular Dance Teachers near Pelham, NY
Check out some of our most popular teachers near Pelham, NY including Bronxville, New Rochelle, Larchmont, Mount Vernon and Eastchester.
About Stephen H.Close
students can select the style of dance they wish to master and will learn will improve overall balance, choreology, and performance skills. students will also learn terminology and work on flexibility, strength, and muscle control. these lessons are based more on improving ability, not technique.
About Stephen
I have been teaching dance as a choreographer for over 5 years. The focus is on precision and performance. I specialize in technique and pedagogy for all levels of dance as well as movement, staging, and stage presence for dance theater performances. I embrace raw talent a
*** Lesson Details ***
Lessons will be both entertaining and challenging. Each lesson will be energetic from start to end and will be tailored to meet your needs and match your pace. Rest assured students will walk away from every lesson with new dance history knowledge as well as improvements in dance. The private lessons can prepare you for auditions, performances, and special events, or simply increase your strength and enthusiasm for dance.
*** Studio Equipment ***
none. lessons will be private lessons on site.
*** Travel Equipment ***
I will bring music, speakers, and sometimes worksheets. I can work in any open space in your home.
*** Specialties ***
contemporary, lyrical, Modern.
Jazz, Broadway, hip hop, Caribbean.
· Dance · In home
· Ballet · In home
· Dance · In home
Stephen H.
Stephen H.
About Michelle R.Close
View Full Profile
I have and am continuing to study ballet, modern/contemporary, and jazz. I received a BFA in choreography and performance, so I hold the ability to coach as well.
About Michelle
· Dance · In home
· Dance · In home
Michelle is a patient knowledgeable teacher. She started me with basic dancing steps to "Panda Bear - Doin' it Right ." The basic dance steps that Michelle taught me can be used for virtually all Rock/Disco/Techno music that you will encounter. The tempos might vary, but the steps remain the same. When I became more proficient Michelle taught me line dances such as the "Macarena" and the "Cha Cha Slide."
When I attended the Wedding reception with the Dance minor, I was confident and comfortable on the Dance floor thanks to Michelle!
Highly Recommended.
Michelle R.
Michelle R.
About Olga K.Close
I've been teaching ballroom dances for a few years . Within the first few lessons, you'll be able to learn couple of basic moves and start dancing with different kind of music. As time goes on you'll be able to learn more fun moves and go further in technique and have fun when you dancing) I specialize in ballroom dances as well as in wedding dance. I love working with students of all ages and experience levels and I can't wait to meet you!
About Olga
Just tell me your goals and we will try to achieve them.
· Ballroom Dance · In studio
· ·
full of talent and grace.... comes well prepared...
and makes you feel so comfortable as she eases
you right into it....
I would highly recommend her
· Dance · In home
Olga K.
Olga K.
About Cheyenne G.Close
About Cheyenne
My name is Cheyenne and I have been teaching dance for four years. I started when I was fourteen years old teaching at a summer intensive in 2010 and I've been teaching ever since around the country. I have been a dancer for fifteen years and I continue myself to grow everyday. I currently attend college at AMDA a performing arts school, and am in the process of getting a degree in Musical Theatre. If you have any questions about my experience please feel free to ask.
Hope to be working with you!
Cheyenne G.
Cheyenne G.
About Da-Rell T.Close
You just want to learn how to boogie when the music hits you? Or maybe even feel more comfortable socializing when out and about? I can teach you the skills required to impress your audience and attract the right kind of attention when on the dance floor or just moving with the music.
I have been teaching dance for over 15 years, ever since starting dance clubs in high school. I learned I loved teaching and I loved to learn from others.
My goals as a teacher is~~~
~To cultivate my students' talents, strengths, and abilities in as little as one training session.
~To raise my students confidence in skills they didn't know they already possessed.
~To open the students mind on ways of thinking about rhythm and movement that can have physical results.
~To pass on knowledge
About Da-Rell
I can teach: popping, locking, waving, tutting, liquid, sliding, house, footwork, breakdancing, acrobatics, choreography, improvisation, and theatrical.
I can help you build your own style. A style that specifically pertains to you. I'll show you how to incorporate concepts, themes, and ideas, to tell a story, or to just express yourself through movement and rhythm.
I love teaching, and I love that look i
If you want to learn hip hop, house, or fusion- I am a very patient yet motivating teacher. I can be strict at times, but only when needed ;-)
Classes focus on ideas and concepts as well as ways to act them out. We learn how to utilize balance, emotion, finesse, attention, and focus to transition between movements. Exploring performing with character, style, technique, and form to develop their own individual philosophies on movement. We dissect different instruments and rhythms to experience them in different parts of the body. Integrating hip hop, ballet, modern, house, and martial arts into one cohesive style.
My goal is to foster artistic growth and to help you surprise yourself!
· Hip Hop Dance · In home
· Dance · In home
· Hip Hop Dance · In home
Da-Rell T.
Da-Rell T.
About Chelsea S.Close
View Full Profile
I have 23 years of classical dance training. I received a bachelor's degree in dance and continue to perform and work in the field professionally. My goal is to provide a warm, welcoming, and safe environment for my students that challenges them both physically and intellectually.
I specialize in contemporary, modern, and ballet.
About Chelsea
I teach movers of all ages and specialize in ballet, modern, contemporary, and creative movement for children.
· Dance · In studio
She's capable of teaching many different dance styles and was genuine and caring with my children. Definitely going back in the fall for privates!
Chelsea S.
Chelsea S.
About Iman B.Close
Interested in Dance lessons? You've come to the right person!
About Iman
She graduated from Florida State University with a BFA in Dance and it is there where Iman discovered her love for fitness. Taking many courses in Pilates, crossing training with athletes, and being in Ballet class every day gave her a plethora of knowledge and insight. she is looking forward to helping you reach your goals whether it's in a dance class or perfecting your lunges!
Dancing professionally in NYC and abroad with a variety of artists and companies in addition to training clients with specific fitness needs has been a whirlwind experience. She most recently performed onboard the Norwegian Escape doing Broadway's "After Midnight".
As an instructor, I would love to know what you are looking to accomplish and I will tailor my lessons/ workouts to fit you. Be as specific as possible! I want you to get the results you are looking for in a fun and educational environment.
I will travel to your home/ home gym/ or I will find a gym in your area!
Iman B.
Iman B.
About Carolyn M.Close
Interested in dance lessons? Carolyn began working professionally at 8 years old and has since appeared on stage, in national commercials, recorded voiceovers, and booked principal roles in both film and television. She earned her Bachelor of Fine Arts in 2011 from the Boston Conservatory, where she majored in musical theater with an emphasis in directing. With years of extensive dance training, she's had the opportunity to perform the original Broadway choreography in several major productions she has been a part of, her favorite being the tap spectacular "42nd Street." As an award winning choreographer, her pieces have been recognized nationally at dance competitions across the country.
About Carolyn
· Singing · Online
Furthermore, she has a strong song-writing and production background and has acted as a producer of sorts in the best way possible, challenging me to work outside of my comfort zone in order to help me package the music I've written into the best songs they could ever be.
She really knows what she is doing, is extremely personable, and I highly recommend her for anything music-related!
· Singing · In studio
I had a fabulous time for the time I spent in New York studying with her.
· Singing · In studio
Carolyn M.
Carolyn M.
About Ann D.Close
Hello, I am a traveling dance teacher and am willing to come to you or a location near you to provide you with dance instruction out of a selection of multiple styles. I teach modern and classic styles of dance. I do weddings, group classes, and private lessons. Check my website out and contact me with any inquiries. -Ann
About Ann
Ann D.
Ann D.
About Laura P.Close
I am here to help, explain and train you, so that you can learn and participate this amazing art form and express yourself freely.
Let's dance and make it happen!!!
About Laura
LaUra's attraction and passion for dance flourished over the years. Ballet school in Uzbekistan evolved to practices of Russian, Uzbek and international folklore dances under the supervision of well-known professionals.
She began her professional career as a belly dancer in Lebanon, where she met Mr. Siranossian one of the biggest entertainment agents, who offered her an opportunity to tour around the Middle East – Lebanon (Beirut), UAE (Dubai, Abu Dhabi), Yemen (Aden) as well as in Switzerland and India.
LaUra is a winner of many belly dance competitions such as RAKSTAR, MIAMI BELLY DANCE CONVENTION, LAS VEGAS BELLY DANCE CONVENTION.
Currently, LaUra is the founder, choreographer, and director of dance and ent
She is also owner of her dance studio in Brooklyn, NY where she teaches kids and adults how to belly dance.
Laura P.
Laura P.
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Dance Lesson Reviews from Students
Students are raving about their Dance instructors on TakeLessons. Check out some of these recent reviews.
From our first phone call, Gina became invested in my dance journey. From modern dance, to ballet and contemporary, Gina has guided m
She's capable of teaching many different dance styles and was genuine and caring with my children. Definitely going back in the fall for privates!"
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Recent Dance Articles from the Blog
Whether you're just starting out or a seasoned pro, check out the Dance articles on our blog.
Choreographing Creatively | How to Choreograph a Dance
Curious about choreography? Get started with these simple methods and tips from New York City actor, dancer, and teaching artist Jasmine B... Choreographing is an elusive art; sometimes we master it in moments, other times we can only sit in an empty studio with a pad of paper and our bodies in limbo. After learning how to choreograph a dance for myself, from some of the most innovative artists in the country, and witnessing some pretty phenomenal new pieces, I've noticed and st … Read More


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good old NVidia TDR strikes again. Important Links Terms of use Privacy Policy Donation Terms Print Spooler Repair Tool Feedback Email Support Form FeedBack Old3 Contact us Log in Disclaimer techsupportall.com is an independent website. February 6, 2013 LinuxRules I agree with the first two comments! You will need to restart IE after changing this setting. http://advancedcomputech.com/internet-explorer/ie-crashing-help-please.html
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thanks Reply Jimena July 3, 2013 at 9:34 pm the article has helped me with my technical problem Reply sousan June 19, 2013 at 8:43 am Thanks for your support. Safe mode with networking would stop all third party security, So between IOBit and Avast is own new concerns :/ Lets see the add-ons first but I would go ahead and I can't thank you enough!!! Tell me, what exactly happens when you double-click on IE?
Now i use firefox! To run sfc.exe, open an admin-level command window and then type: sfc /scannow Let the scan run to completion; then follow any on-screen instructions that appear. press start type andinetcpl.cpl and then press enter(open it)2. Internet Explorer Performance Troubleshooter http://support.microsoft.com/mats/ie_freezes_or_crashes/ http://support.microsoft.com/mats/ie_performance_and_safety/ Restart the computer.
Event Viewer steps to finding which file was related to the IE stopped working error: Right click on MyComputer and then click on Manage. Internet Explorer 11 Crashes Windows 7 64 Bit If IE starts fine using the above steps, you'll want to track down which add-on is causing the problem. While BHOs can often cause this, and the Microsoft Community and forums advocate this fix, the source of the problem is actually the ram module in Bank0. http://www.howtogeek.com/136193/how-to-troubleshoot-internet-explorer-crashes/ do a simple google search to see your success.if the problem still persists try and find the most recent windows update and uninstall it.
I'm a Sithbot:) Joined : Feb 2015 Bamberg Germany Posts : 12,894 Microsoft Windows 10 Pro 64-bit 14393 Multiprocessor Free New 27 Sep 2015 #2 Oh yeah, one more thing: Internet Explorer Keeps Freezing And Not Responding Strange enough …this was the first site I saw but bypassed it like an idiot. untick Internet Explorer, click okay this will uninstall Internet Explorer4. Using method 8 I was able to identify IE's NSIB.DLL module was faulting causing the error.
Solved Answer If you get this error message 'Internet explorer has stopped working'. Method 1 : Reset Internet Explorer Reset Solution 1: Open Internet Explorer. Internet Explorer Keeps Crashing Windows 10 Even now, there are reported security "holes" in IE that simply aren't a problem for most other browsers. Internet Explorer 11 Keeps Crashing Windows 10 So I uninstalled IE 9, but IE 8 would not open either.
This PC dont usually reboots on its own. http://advancedcomputech.com/internet-explorer/explorer-always-freezing-crashing-very-slow-computer.html Reply Abdulla February 21, 2016 at 10:06 am I will Add One More thing is import I tried all but nothing happen I remove Real Player Now Working 100% Reply Techexpert If crashes continue to occur, you have another problem. I have attempted to run Startup Repair from a disc with no luck. Internet Explorer 11 Not Responding Windows 7 Fix
Fix Freezes or Crashes with these resources from The Windows Club: Google Chrome Browser crashes Mozilla Firefox Browser freezing Windows freezes Windows Explorer crashes Edge browser hangs Windows Media Player freezes numerous errors: display adapter, install errors, uninstall errors, IE10, Firefox and IE 11 crashes. If it works fine, then it is obviously one of your add-ons that may be causing problems. http://advancedcomputech.com/internet-explorer/help-ie-keeps-crashing.html But what if resetting the browser doesn't work?
Use the Manage Add-ons tool, and disable each one after the other to find out which one is causing the problem. Internet Explorer 11 Freezes I had heard that if I uninstall it then reinstall it that the problem would be fixed but when I go to uninstall it I am unable to find it in So I looked at the crash logs in Reliability History, and found out that it's iertutil.dll that seems to be the culprit: Normally that could mean either the .dll is corrupted
Reply Techexpert March 10, 2015 at 7:13 am Could you please give us its location as well? I had found the first 7 of your suggested fixes - usually from people who insisted that it was the one and only solution. And btw, as soon as I booted back up into normal windows operation, I got a display adapter error ... Internet Explorer Keeps Crashing Windows 8 Who would have thought that the solution was so simple?
Method 7 : Run Microsoft Fixit's Download and run these Microsoft fixit to resolve that problem. So if IE keeps crashing, and in Reliability History it gives you that .dll, give this solution a shot. Advt ^ 5] You may want to read this article on how to Repair Internet Explorer and see if something helps you. 6] You can also see if the Internet Explorer http://advancedcomputech.com/internet-explorer/internet-explorer-keeps-crashing.html I identified the rogue .dll file and uninstalled it, (it turned out to be an annoying shopping ad file !).
Please kindly give me an advice.. Close all tabs and windows, and then shut down IE. Thanks a lot. Reply GHIULLIANO August 26, 2014 at 10:21 pm good job !!
Recent Comments News Posts on TWCNMicrosoft announces Data Science Utilities version 0.11Windows Hello now supports multiple secured companion devicesMicrosoft Azure and Office 365 gets DOD Level 5 PAWindows 7 users receiving In fact, I install computer all the time at clients offices and have yet to NOT have this issue on ANY computers. In the Reset Internet Explorer Settings dialog box, leave the "Delete personal settings" box unchecked to preserve items such as stored website passwords. Type "iexplore.exe -extoff", then press "Enter".
My System Specs Computer type PC/Desktop System Manufacturer/Model Number Cyberpower OS Windows 7 Premium x64 SP1 CPU 3.8 ghz AMD FX-4300 Quad-Core Motherboard 760GM-P23(FX) (MS-7641) 3.0 Memory 8 MB Graphics Card Perhaps those are bad examples since they don't exactly come from Microsoft - not that Microsoft could warn us via the updates process or anything. Reply Tj June 2, 2015 at 5:01 pm Hello, problem dll is nvundshim.dll but I don't have stereoscopic 3D?


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Upcoming Events
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Are you or were you ever a part of the Cross Cultural Centers family? We welcome you to share your experiences on camera! Be a part of the story. Visit website to submit your experience via photo, video or 75 word statement.
This fair will be attended by recruiters including The Walt Disney Company, The Los Angeles City Attorney's Office, and Los Angeles Unified School District.
Pronounced as "cutie pock," stands for queer and trans people of color. QTPOC Thursdays is a weekly gathering space for queer and trans people of color to ask questions, explore, and dialogue about gender, sexuality, race, ableism, politics, pop culture and so much more every Thursday.
Arrested at 16 and tried as an adult for kidnapping and robbery, Eddy Zheng served over 20 years in California prisons and jails. Breathin': The Eddy Zheng Story paints an intimate portrait of Eddy -- the prisoner, the immigrant, the son, the activist -- on his journey to freedom, rehabilitation, and redemption. Directed by Ben Wang, 2016, 61 minutes.
Join the Cross Cultural Centers and Women's, Gender, and Sexuality Studies for a field trip to Laemmle's Playhouse Pasadena for a screening of Dolores, a new documentary on the life and activism of Dolores Huerta, on Sept. 15 at 1 p.m. Sign up starting Sept. 1 at 10 a.m., U-SU Room 306 for $10, which includes transportation and movie ticket. Departure time and trip information provided at signup. Participants must use transportation provided by the U-SU.
University closed.


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Ellen DeGeneres fingers door as cause of injury
Ellen DeGeneres's finger has never been more famous. More »
Ellen DeGeneres's finger has never been more famous. More »
If you follow The Superficial on Facebook and Twitter, then you have a ginormously long penis and already knew to skip the Grammys and wait patiently for pics of Katy Perry's giant breasts because they're the only thing worthwhile that happened. Don't get me wrong, I'm still going to post stupid shit like Chris Brown… More »
Ellen DeGeneres and Portia de Rossi made good on their promise to immediately wed once the ban against gay marriage was deemed unconstitutional in California. Somewhere, John McCain just went "Huh? What? I want tapioca." People reports:
"Ellen DeGeneres and Portia de Rossi were married tonight in an intimate ceremony at their home in… More »
Ellen DeGeneres and Portia de Rossi are taking immediate advantage of the California Supreme Court ruling that struck down the ban on gay marriage. The two plan to wed according to a spy for TMZ who was on the set for the latest episode of Ellen that will air today:
She surprised everyone and… More »


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Phantom 4 Pro+ - Production Aerial Kit
$ 2,372.00
NOTE: The Phantom 4 Pro Plus remote controller has an integrated tablet built in, the tablet does NOT run 3rd party apps. Only DJI Go 4.
With our Phantom 4 Pro bundle, you will have everything you need to get out and start producing some of your own content. We include the new DJI Phantom 4 Pro Plus drone, but we also include a travel case for the drone, spare batteries, and additional complimentary items. The DJI Phantom 4 Pro+ comes with the new DJI controller with the built-in screen.
This kit includes the following item(s):1 - DJI Phantom 4 Pro Plus Drone (RC with 5.5 Inch Screen included)
2 - Spare Intelligent Batteries
1 - Multi-Charger
1 - Phantom 4 Custom Wheeled Case (Props On)
1 - Polar Pro Phantom 4 Pro Filter Pack - Cinema Series - Vivid Collection
1 - DJI Phantom 4 Car Charger


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Members of a cricket team in Kashmir made headlines in the last few days for wearing Pakistan jerseys, as well as singing the national anthem of the neighbouring country, with which India has not had the best of relations.
If latest reports are to be believed, members of the Baba Darya Ud Din team were detained on Wednesday by local police in Ganderbal in central Kashmir, with a National Investigation Agency (NIA) team slated to visit the Valley later to further probe into the incident.
Central Kashmir deputy inspector general of police, Ghulam Hassan Bhat, confirmed the development in a report in the Hindustan Times.
"The boys are in the police station," Bhat was quoted as saying in the report.
Security in the meantime has been beefed up around the police station after local residents gathered around it demanding the immediate release of the 11 players in question.
The clip showing the players wearing the green jerseys were first uploaded by the Kashmir Media Service. They also carried a report for the same, which identified the venue of the match as the Wayil playfield in Ganderbal on 2 April.
The video caused a furore in India, especially in the backdrop of the recent cross-border tensions between the two neighbours. Terror attacks such as that at Pathankot in January 2016, as well as the Uri attacks later that year have worsened relations in recent times.
The tensions have spilled over to the cricket field as well, with the Board of Control for Cricket in India (BCCI) refusing to entertain a bilateral series with Pakistan despite signing a Memorandum of Understanding (MoU) with the Pakistan Cricket Board (PCB) in 2014 that included six bilateral series, two of which have already been scrapped.
The PCB is reported to be filing a case before the International Cricket Council (ICC) against the BCCI for losing out on revenue due to the cancelled series, and said it will not hesitate to approach the courts in case the ICC fails to deliver them justice.
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Couples' Paint Night
You guys deserve a break! Join us for a fun night out, under the guidance of our very own master artist, Rebbitzin Sara Bernath. With a glass of wine, you'll unleash your inner artist as you create a piece of art. No artistic skill required.
What to expect:
- A laid-back, upbeat atmosphere with music and laughter.
A really nice selection of Kosher wine throughout the night.
A step-by-step painting tutorial with everything provided for you.
- You'll take home your own painting that you can be proud of.
Saturday Night, November 19, 7pm
Advanced Registration (until November 17th): $35 per couple - Chai Members: 25$
At the door: $70 per couple
All materials included. Just bring yourself.
This is a special event just for couples - you are welcome to bring your significant other or your best friend.


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Glass Ball Table Lamp uploaded by Marquis Block on Saturday, October 15th, 2016. We have 3 great pictures of Glass Ball Table Lamp. Find New Home Interior Design Ideas Chronus-Imaging.com Luxurious Style Unlike Anything Else on category Unique.
See also Outdoor Lights For House from Unique Topic.
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All videos -Audio-bible - Most of the new testament letters of Paul were adressed to cities in the country now called Turkey. It is amazing to see that most of these cities are now MUslim! PPaul was the apostle sent by God to the gentiles whas for Peter was the apostle send to preach to the Jews! What a ministry, walking all thgoughoue eastern Asia and Europe, traveling to Greece and seeing the Acropolis and Athens in all its splendor! onlinebible, biblegateway audio bible, audio bible gateway,
Mighty signs were wrought by Paul. Most cities received God's message of the bible through the preaching of the apostle Paul. Some cities, like Athens whee many deities existed, Athens which was the center of higher learning, because of how they thought of themselves and their intelligence, God could not do many miracles there! Self was too strong and present for God to exist in their hearts! The bible accounts in Paul travels reveal how a true christian should ive, spending part of his life preaching the mssage of God and salvation through faith in the atoning sacrifice of Jesus! onlinebible, biblegateway audio bible, audio bible gateway,
Holy bible: 2 Corinthians 1 ' 1Paul, an apostle of Jesus Christ by the will of God, and Timothy our brother, unto the church of God which is at Corinth, with all the saints which are in all Achaia: 2Grace be to you and peace from God our Father, and from the Lord Jesus Christ. 3Blessed be God, even the Father of our Lord Jesus Christ, the Father of mercies, and the God of all comfort;
4Who comforteth us in all our tribulation, that we may be able to comfort them which are in any trouble, by the comfort wherewith we ourselves are comforted of God. 5For as the sufferings of Christ abound in us, so our consolation also aboundeth by Christ. 6And whether we be afflicted, it is for your consolation and salvation, which is effectual in the enduring of the same sufferings which we also suffer: or whether we be comforted, it is for your consolation and salvation. (read more...)
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Asscherick david four your faith
Asscherick david how Jesus will return
Asscherick david how near is the end?
Asscherick david how not to get the mark of the beast
Asscherick david logic of revival
Asscherick david there is really a final judgment
Asscherick david the USA in Bible prophecy
Audio bible acts of the apostles
C.D. Brooks questions and answers
Christian experience and teachings book
Conflict in the last days book
Creation evolution debates infidel guy
Creation evolution debates dr Shermer
Creation evolution debates rainbow
Darlene zschech what is worship?
David gates converging crisis 2
David gates crossing the jordan
David gates crossing the jordan 2
David gates crossing the jordan 3
David gates i have heard my people's cry
David gates questions and answers
David gates will the real adventist stand up?
David gentry center of the earth
David gentry creation's tiny mysteries
David gentry dark clouds of the big bang
David gentry fingerprints of creation
David gentry microscopic chances
David gentry what horrors the hubble wouldn't face
Doug batchelor final countdown
Doug batchelor God's mighty men
Doug batchelor is there anything we can trust?
Doug batchelor from pit to palace
Doug batchelor rest of the story
Doug batchelor revelation rapture
Dr day diseases don't just happen
Dr day what does the bible say about doctors?
Enfrentando a los gigantes movie
Evolution, foundation for the antichrist
Evolution, foundation for the antichrist 2
Evolutionists refuse to debate creationists
Hugh ross creation as a science
Hugo gambetta amonestacion solemne
Hugo gambetta mensage de elias
Hugo gambetta obreros de la hora undecima
Hugo gambetta pasa esto llamados
Hugo gambetta purificacion del sanctuario
Hugo gambetta plan de salvacion
Illuminati the history channel
Jan marcussen beauty meets the beast
Joe maniscalco new world order
Keep the faith sunday law is coming
Keep the faith sunday law and europe
Keep the faith sunday law and 9/11
Kent hovind dangers of evolution
Kent hovind lies in the textbooks
Kent hovind lies in the textbooks 2
Kent hovind the bible and health
Le temple de l'Apocalypse révélé
Los valles fertiles de mesopotamia
Marco barrientos cree todo es possible
Marco barrientos muestrame tu gloria
Marcos witt sana nuestra tiera
Mark woodman is this the end of the world?
Mark finley alive at end times
Mark finley beginning of the end
Mark finley countdown to eternity
Mark finley greatest religious cover up
Mark finley near death experience
Mark finley remedy for tension
Mark finley revelation judgment
Mark finley why so many denominations?
Quand les bergers se transforment en Bètes
Schizofrenia and nutritional therapy
The chronicles of Narnia movie
The french revolution history channel
The great debate 2 wilder smith
The lost pages of christianity
The extreme oath of the jesuits
Thoughts from the mount of blessing book
Time and creation Wilder smith
Visiting paris the bible way 2
Walter veith a woman rides the beast
Walter veith catholic islamic connections
Walter veith man behind the mask
Walter veith origin of variety
Walter veith papacy admits sda truth
Walter veith revolution tyrants
Walter veith the wine of babylon
Walter veith u.n. and occult agendas
Why my mother did not become a Jehovah's witness?