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Weighted average cost of capital – Wikipedia – The weighted average cost of capital (WACC) is the rate that a company is expected to pay on average to all its security holders to finance its assets.
Finance Google Slb Alternative to google finance api – Stack Overflow – I wanted to use Google Finance API to get stock data about company but this API is deprecated since 2011/26/05. So my question is simple 🙂 What do you use as free … Finance Careers 10,476 jobs globally in Finance, Banking, Accounting … – Browse finance
Finance Leased Cars Corporation Tax Subaru Cars, Sedans, SUVs | Subaru of America – Active Military Discount Program. Subaru is proud to offer a special discount to active duty members of the U.S. Air Force, Army, Navy, Marines, National Guard, and … 2017 Lincoln MKZ | Models & Options | Lincoln Canada – View all available models of the 2017
Weighted Average Cost Of Capital (WACC) – Weighted average cost of capital (WACC) is a calculation of a firm's cost of capital in which each category of capital is proportionately weighted.
Financial Leverage – Investopedia – Sharper Insight … – Financial leverage is the degree to which a company uses fixed-income securities such as debt and preferred equity. The more debt financing a company uses, the higher …


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Drunter & Drüber | Neustadt-Festival opening hours
The "Drunter & Drüber" Neustadt-Festival is on this weekend, so we have different opening hours this Friday and Saturday as well as a guided tour for our exhibition TRACES OF MINIMALISM, featuring artwork by Olly Fathers, Alan Steele, Yukako Shibata, DongHwa Lee, Swen Kählert and Tanja Soler Zang.
For the complete Program of the Festival, please check this website: DRUNTER & DRÜBER
Here's more info on the guided tour to all galleries in the quarter: Gallery Walk / Galerien-Staffellauf
Opening hours of the gallery:
Friday, Sept 16: 4–9 PM
Saturday: Sept 17: 2–7 PM
Images from the opening of "Traces of Minimalism" are online here.
You can view the exhibited artwork by clicking here.

subset: commoncrawl


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|Results 1 - 4 of about 8 for MLK Parade. Search took 0.04 seconds.
SDCCD marches in 2017 MLK Parade
|San Diego Community College District faculty, staff and students walked
in the 37th annual MLK Parade on Sunday, Jan. 15 to honor ...
www.sdccd.edu/newscenter/multimedia/mlk-parade-2017-photo-gallery.asp - 26k
|... Video: 2016 MLK Parade. January 20, 2016. |. San Diego Community College District.
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March in the 37th annual Martin Luther King, Jr. Parade
|... 15. Two days before the parade, SDCCD representatives will attend the 32nd annual
Martin ... 14, the district will take part in the MLK Educators Breakfast at the ...
www.sdccd.edu/newscenter/articles/martin-luther-king-jr-parade-event.asp - 21k
Continuing Ed takes 1st Place for MLK float
|... year. Welding program students and staff, and others from SDCE, have
participated in the MLK Jr. Parade for the past 12 years. The ...
www.sdccd.edu/newscenter/articles/continuing-education-first-place-mlk-float.asp - 22k
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Willard Care Centre
Talk to a Family Advisor:
Reviews of Willard Care Centre
lookingforchange January 28, 2012
I am a friend or relative of a resident
There are several ways in which I was pleased with the facility. It seemed very clean, the residents seem cheerful, and the overall atmosphere was one of caring. However there are days that I am not impressed. For instance the day we brought my aunt in there were several nurses on duty and not one of them offered to help after she was in the building. They did not appear to be busy and we had to ask them several times if we needed something. I have been in there and seen a resident's 'assistance needed' light on for long periods of time with no one coming to aid. This includes an incident with my aunt. There are many friendly and caring people employed here and there are some who are very apathetic and lazy.
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About Willard Care Centre
Willard Care Centre is a nursing home in Willard, MO that provides patients with skilled nursing care as well as private or shared accommodations. Contact Willard Care Centre for more details on housing, services, and rates.
Features of Willard Care Centre
Medicare (ratings last updated: 06/16/17)
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- Ownership Type: For Profit Corporation
- Date Certified: 05/01/2017
- Resident Capacity: 66
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Representatives from the Isle of Man have shared the territory's expertise in the area of criminal justice to assist the UK's other overseas territories in undertaking reform in the area, at a recent event in London co-organized by the UK Foreign and Commonwealth Office (FCO) and the Ministry of Justice.
The workshop provided an opportunity for Governors from seven of the Overseas Territories to hear of the development of the Isle of Man's acclaimed criminal justice system from Mark Kelly, the Chief Executive Officer at the Isle of Man's Department of Home Affairs, and Dan Davies, who has appointed by the Manx Government to spearhead efforts to make Government operations more efficient.
The workshop was organized to assist in the UK Government's efforts to encourage reform by its Overseas Territories to strengthen good governance, public financial management and economic planning, in line with the recommendations of the FCO's white paper reviewing the UK's relationship with the Overseas Territories. The UK Ministry of Justice had previously highlighted the Isle of Man's criminal justice modernization strategy to the Overseas Territories as an example of best practice.
The Isle of Man's Home Affairs Minister with responsibility for criminal justice modernization, Juan Watterson said: "The Isle of Man has a strong track record of international cooperation and we were pleased to take this opportunity to engage positively with the Foreign and Commonwealth Office, Ministry of Justice and Overseas Territories. The invitation to attend the event in London recognizes the quality of the work we are undertaking to make the island's criminal justice system faster, simpler and more cost efficient."
"Many countries around the world are facing common challenges in terms of delivering more for less, and the Isle of Man's experiences in driving forward its modernization strategy really struck a chord with the Overseas Territories."
Mark Kelly added: "It was extremely gratifying to see the level of interest from the Governors of the Overseas Territories, both during the presentation and in the margins of the workshop. Jurisdictions such as Bermuda, Turks and Caicos and the British Virgin Islands have all approached the theme of criminal justice reform but recognize the Isle of Man is already well advanced in this area. A number of Governors expressed their interest in visiting the Isle of Man to consider at first hand the progress achieved to date in our program of change."
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Oh No El Niño
February 21, 2016
Hang on for a minute...we're trying to find some more stories you might like.
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It is a mystery to no one that we are having a warmer than normal winter. With a record breaking 70 degree Christmas and the first confirmed hurricane in January since 1938, it has begun to leave me wondering "Where did winter go?".
There seem to be many factors contributing to our extraordinarily abnormal winter. The first factor is "El Niño", a term is thrown around a lot in the media, but what is it actually? El Niño is the warm phase of the El Niño-Southern Oscillation (ENSO), which is indicated by above average ocean surface water temperatures in the area off the coasts of Colombia, Ecuador, and Peru stretching in a horizontal stripe westward across the Pacific. This water, which is many degrees Celsius above normal, causes the usual distribution of thermal energy in the air to become disrupted and results in warmer and drier than normal winters along the northern extent of US and cooler and wetter than normal winters along the southern extent of the US. So for us North easterners that means a warmer and drier winter. However, this is only partially responsible for our so irregular winter.
The trend of global warming has been recorded and established officially since 1975 following a study of how airplane emissions affect trace gasses in the stratosphere (Ozone), and the evidence to support it has only mounted since. 2015 was the warmest year on record, breaking the previous record held by 2014, and topping out the list of the top 10 warmest years on record (all of which have been recorded since 1998). The global average temperature of 2015 was 2.4 degrees Fahrenheit above the 20th-century average. It is agreed upon by 97 percent of actively published climate scientists agree that warming trends of our planet are human caused. There is no longer a debate on whether or not our planet is warming, and there is only a small minority of climatologists who dispute the fact that it is human caused. Currently, the global average carbon dioxide parts per million (CO2 ppm) is at 401.85, which is around 100ppm above the highest measured CO2 ppm in Earth history. Being a greenhouse gas, these excessive amounts of CO2 is trapping increasing amounts thermal energy rebounding from Earth's surface that usually would have escaped the atmosphere and dissipated in space. Since the beginning of the industrial revolution Human activity (specifically the burning of fossil fuels) has resulted in an almost 110 parts per million increase in atmospheric CO2 concentrations. At the rate that we are pumping CO2 into the atmosphere and the rate at which the Earth is warming as a result, it is becoming increasingly likely that within the next 50 years Connecticut will have a climate that more summarily matches that of South Carolina than what we have now. This winter seems to be just a taste of what the reality will be in the near future, and I don't like it.
However, hope is not completely lost for our planet. Since there is no one over the hill who is coming to save us we are going to have to save ourselves, which is something we already know how to do. To prevent this unusually warm winter from becoming an average winter in the future, all we have to do is reduce our CO2 emissions, which is easier said than done. With the completion of the 2015 United Nations Climate Change Conference (COP21) in Paris, last year leaders from 149 countries have agreed to make significant reductions in CO2 emissions, with President Obama pledging to reduce our emissions by 26%. This conference was a massive step in the right direction, it was the first time that world leaders had ever recognized and acted upon climate change as they tried to prevent global average temperature change due to human activity from climbing above two degrees Celsius. While climate change may seem like a problem too big for any one person to effect or that it should be handled by only the leaders of the world, there is a lot you could do. Things like turning off the lights when you leave the room, turning down the thermostat, and driving a more efficient car are all very good ways of reducing your carbon footprint since transportation and residential sectors account for just over 30% of emissions in the US. But one of the most important things you could do is writing a letter to your congressman and exercising your right to vote. Electricity production accounts for 31% of all emissions in the US because the vast majority of US power is produced by burning fossil fuels. While electricity production may seem out of your hands, by writing to your congressman or voting for an official who supports green energy your voice can be heard and policies can be changed. To avoid this storm looming on the horizon we need to make some big changes, and one of the best ways to do that is to make sure the people in charge are ready to act. The time to act is now, or winter maybe becomes a forgotten season.


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Specializing in EB-5 Visas
for permanent U.S. residency for foreign investors
(301) 276-0653
Senior Attorney
I.A. Donoso & Associates
Fiona received her bachelor degree and master degree in law from Peking University, and her LL.M. degree from Georgetown University Law Center. Before joining I.A. Donoso & Associates, LLC, she was practicing in the field of securities and corporations in China. She is licensed to practice in New York and China. Fiona is fluent in English and Mandarin Chinese.


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APPSC Recruitment 2017 – Arunachal Pradesh Public Service Commission, Itanagar is going to conduct APPSSC Pre Exams-2017 for the recruitment of various posts such as APCS, APPS, Child Development Project Officer, Assistant Director (Industries), District Food & Civil Supply Officer and Assistant Station Superintendent. Hence, interested candidates can apply through prescribed application form from the […]
Tag: APPSC recruitment 2017
|10th Board Result 2017
|SSC CGL Admit Card 2017
|Government Jobs 2017
|NDA 1 Admit Card
|12th Board Result 2017
|Bihar Police Admit Card 2017
APPSC Recruitment 2017 for Lecturers in Govt. College | Apply Online (ORA) before 28th of Jan. 2017 |
Andhra Pradesh Public Service Commission has release online application form for the posts of Lecturers in Government Degree College and interested candidates can apply for online application form before last date. For more information visit the official site or keep touch with our site. Andhra Pradesh Public Service Commission is a department of Andhra Pradesh […]


text: Answer this question: Retrieved from "http://inquiringmoms.answers.wikia.com/wiki/When_should_I_allow_my_daughter_to_wear_makeup?oldid=13096" Ad blocker interference detected! Wikia is a free-to-use site that makes money from advertising. We have a modified experience for viewers using ad blockers Wikia is not accessible if you've made further modifications. Remove the custom ad blocker rule(s) and the page will load as expected. Tags: Un-answered questions Makeup Girls Add category Cancel Save


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Περισσότερες ιδέες από το
Want to win an awesome vacation to sunny St. Lucia + a $1500 J.Crew shopping spree? (that's a lot of bikinis and cover-ups) www.jcrewbeachple... #beachplease
Summer and the sea
Flamingo palmtrees | 18 Easy Summer Nail Art for Short Nails
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What type of nail art best matches your inner self?
Pretty Palm Tree Nail Art design. The skies are painted in soft morning colors with hints of yellow. The palm trees and the birds are seen in silhouette styles overlooking the beach.
Hair goals!!! Bronde, hair inspiration, shoulder length hair, long hair


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The 60-year-old star was treated in hospital in Arizona on Tuesday, her agent, Shelly Schultz, told the Associated Press news agency.
Ms Schultz refused to disclose details about the surgery, but said that it was not for cancer.
Ronstadt - best known for albums such as What's New - was due to perform gigs in September and October.
They included dates in Mexico and Texas.
Speaking about the surgery, Ms Schultz said: "It wasn't an emergency, but it came about rather quickly, so she decided to do it sooner rather than later.
"It's surgery, it's completed, and she's fine."
Ronstadt will recuperate at her home in Tucson, Arizona, for an "undetermined" amount of time, and then travel back to her other home in San Francisco to spend time with her adopted children, Ms Schultz added.
Most Popular Now | 56,514 people are reading stories on the site right now.";


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Rehab day #3.
Quite a lot of progress. We are moving a lot together in the mornings and in the evenings. No activity in between. I am trying to simulate days when she needs to be alone. I am also quitting home often, for short and long periods. Just sitting on the stairs outside, gardening in front of the house, or driving to the mall for shopping. Still in the neighborhood for giving a quick reaction if needed.
But not needed, fortunately. No barking. No peeing. No destruction of doors. Whenever I arrive home, a calm, resting dog is waiting for me, lying on the sofa, belly exposed, tail wagging. Just perfect. If it remained like that as of next week, that would be wonderful.
Key is exercising for at least an hour. In the mornings we run, something I always loved – and the very purpose of adopting this very type of dog and not something else. But something we never really pursued because of the continuous behavior problems. This week I gave it a chance and I have the feeling it was a great decision. On a short leash for now, then the leash will be longer and longer once she has learned never to leave me. Goal is canicross, a totally different type of run where the dog must be the leader and she also must pull – a no-frickin'-way set-up at this point in time. But it is always good to have a goal with a rough path to achieve, is it.
In the evenings she is bringing her backpack with light weights. Strictly on a short leash, properly walking. No sniffing, no looking around, no nothing. Peeing and pooping when I allow, where I allow. Another type of exercise, another type of load for the body and the mind. In the evenings she also has cue exercises: fetching, sitting here or there, whatnot.
These 3 together seem to be the key. This dog is extremely sensitive for losing rules, and I simply must keep that in mind. Any miss of applying those and she falls apart. It cannot happen again.
We have 2 more days to practise – and I very much hope all this anxety issue will be past tense for good, for both of us.


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Eric Thomas Quotes : Eric Thomas is a famous American author and a great inspiring personality of all time. He has also written a book named "The secret to success" in which he write all his life struggles. He stats that once he was homeless and he had to eat from garbage cans, and now a successful motivational speaker in America.
If you haven't heard of him yet, than these Eric Thomas Quotes will surely give you an idea about him. We have compiled the best-est quotes from him to inspire lives of you all. We hope you can connect to these quotes and will share the inspiration with your family and friends.
Eric Thomas Quotes
Everybody wants to be a beast, until it's time to do what real beasts do.
The difference between those who succeed and fail: not taking advantage of opportunities.
When you're great! You attract great! When you're average! You attract average!
At the end of pain is success.
Be stronger than your excuses.
I've got a dream that's worth more than my sleep.
The problem is, you get more excited talking about it, than you do when you actually doing it!
I'm gonna make the rest of my life, the best of my life.
Fall in love with the process and the results will come.
Look in the mirror, that's your competition.
What you envision in your mind, how you see yourself, and how you envision the world around you is of great importance because those things become your focus.
I learned that a real friendship is not about what you can get, but what you can give. Real friendship is about making sacrifices and investing in people to help them improve their lives.
Best Eric Thomas Quotes
Avoid being your own enemy.
I use pain to push me to greatness.
top whining, start grinding.
Stop being average. You're not even good. You were born to be great.
If you're going to go to your next level, your values are going to have to change.
You can't cheat the grind, it knows hows much you've invested, it won't give you nothing you haven't worked for.
Stop the blame game.
Stop looking out the window and look in the mirror!
Success is never on discount! Greatness is never on sale! Greatness is never half off! It's all or nothing! It's all day, every day! Greatness is never on discount!
Most of you don't want success as much as you want to sleep!
Everybody has a dream, but not everybody has a grind.
Information changes situations.
Don't make a habit out of choosing what feels good over what's actually good for you.
When you want to succeed as bad as you want to breathe, then you'll be successful.
Now here's the video of these Eric Thomas Quotes compilation. Please do share with your family and friends and also subscribe to our blog for more quotes.


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Detecting and Eradicating Contraband Cell Phones is a Matter of Public Safety
Jeffrey B. Haidinger, President & Chief Operating Officer, GTL
PRNewsWire – In 2010, former Corrections Captain Robert Johnson was shot six times in an attempted contract killing orchestrated via a contraband cell phone. He survived the ordeal and recently wrote about the dangers of contraband cell phones in The Post and Courier.
Captain Johnson is correct. Cell phones are a particularly dangerous form of contraband, and they have morphed into a national epidemic and a serious public safety issue. As he said, "they are often used to organize protests, plan escapes, intimidate witnesses, facilitate the sale of weapons and drugs, and orchestrate murders from behind bars." It is not only corrections staff who are at risk, but the general public as well.
In November 2016, the Association of State Correctional Administrators (ASCA) sent a letter to the FCC citing examples of the horrific crimes that have been committed because an inmate had access to a contraband cellphone. In their letter, the ASCA asked for the FCC to take immediate action and said that these forbidden cellphones infiltrating correctional facilities nationwide are a "dire public safety threat."
As recently as early July 2017, a convicted kidnapper escaped a maximum-security prison in South Carolina using a contraband cell phone to coordinate the delivery of wire cutters via a drone. While he was later apprehended, this is a huge threat to public safety. This incident occurred almost a week after South Carolina Department of Corrections (SCDC) Director Bryan P. Stirling and other policy makers went before the U.S. Department of Justice and the FCC asking them to take action to defeat contraband cell phones for the safety of their corrections officers, employees, and for the public at large. Technology partners to Corrections like GTL support and share in the concerns recently expressed by the ASCA, SCDC Director Stirling, and other correctional administrators.
The FCC is not the only organization that must participate in solving this problem. Wireless carriers must realize their important role in closing the gap on this public safety issue. Much like the public-private partnership these carriers formed to build and execute the AMBER Alert System, wireless carriers have the resources to help solve the contraband cell phone problem in the immediate future.
Unless wireless carriers take an active role and work with the FCC and the corrections community to solve this problem, security incidents of all kinds will continue to occur. Wireless carriers have a crucial role to play when it comes to building a solution that truly promotes public safety by eliminating these dangerous contraband wireless devices in correctional facilities. As the corrections industry technology leader, GTL is joining the ASCA, SCDC Director Stirling, and countless others that have gone before the FCC to encourage wireless carriers to support the efforts of those who are working hard to better protect our communities.
Consistent with previous FCC meetings and filings, GTL formally submitted comments to the FCC as part of a Notice of Proposed Rule Making (NPRM). In this filing, among other things, GTL stresses that the FCC should allow all available technology options for combatting contraband cell phones and take all the necessary steps to insure wireless carriers actively and fully participate in the development and deployment of those options. Carriers must be partners in the process.
There is no denying it—an inmate escape is a serious public safety issue, and GTL strongly encourages FCC Chairman Ajit Pai and FCC Commissioners to move quickly towards building consensus among all stakeholders, including wireless providers, to develop solutions to tackle this nationwide epidemic. This much-needed change in regulation would give the corrections community a fighting chance at winning this war on contraband cell phones and increasing public safety.
Press Contact: Vinnie Mascarenhas
GTL's Deposit Systems create efficiencies when taking deposits, reduce correctional facility costs, and increase the convenience for friends and family members. GTL offers a broad selection of products to choose from so that the right mix can be created for every facility.
GTL offers multiple options for friends and family to set up and fund telephone accounts, inmate trust accounts, or commissary accounts. This streamlines the payment process for friends and family members seeking to communicate with incarcerated loved ones or provide them with funds.
GTL's innovative technology allows correctional facilities to streamline the release process through a suite of easy-to-use, time-saving products for returning inmate funds at the time of release.
From intake to release, information on all aspects of an inmate's incarcerations are maintained by the GTL Offender Management System (OMS) – including initial intake, charges, sentencing, property, housing, medical, meal planning, scheduling, and temporary release to name a few.
OMS Accounting was specifically designed to meet the needs of correctional facilities of every size. Unlike standard off-the-shelf accounting systems, OMS Accounting offers corrections institutions the exact modules that will help them complete all of their correctional facility's accounting activities.
GTL's Facility Services Secretary allows friends and families to easily access facility information, inmate status, and other services such as court dates, release dates, facility address and directions, rules and policies, visitation information and hours, just by dialing a single toll-free number.
GTL's IQ family of call and voice analysis products offer investigators a range of options for gathering actionable intelligence to combat fraud, criminal activity, and gang and terrorist recruitment by pinpointing the location of a called party, identifying phone type, detecting calls from multiple inmates to a single called party, and identifying inmates using voiceprints.
GTL's data analysis tools include a powerful data mining and link analysis application to identify actionable intelligence critical to ensuring a facility's safety and security. They offer the ability to take any data source for the purposes of analysis, even including the detection of mobile devices and the extraction of its data.
GTL's Intelligence as a Service offering is flexible enough to meet the unique demands of individual facilities. Focused on the development of actionable intelligence, analysts are trained and equipped with the tools to analyze vast amounts of raw data to provide facilities with the proverbial "needle in a haystack." Depending on facility needs, analysts can also be equipped to provide mobile device forensic services to extract data from legally seized contraband phones, thus assisting facilities in shutting down the supply of contraband.
GTL's feature-rich Inmate Telephone System is a turnkey solution that comes complete with all hardware and software, including the telephone network, circuits, monitoring and recording system, call-control system, secure database, telephones, workstations, printers, and associated software.
Message Link provides an electronic alternative to an otherwise inefficient and potentially tainted communication method. As contraband and cryptic messages are entering correctional facilities through an ever-rising level of creativity, Message Link provides a secure, controlled environment for inmate messaging.
The GTL VisitMe video visitation solution allows facilities to transition traditional in-person visitation service to a more secure on-premise or remote alternative. This highly scalable solution can help facilities improve security while reallocating staff time to more critical tasks.
VisitMe Scheduler can eliminate long queues in the visitation area by avoiding the chaos of having a high volume of concurrent visitors at the facility. In so doing, the system also minimizes staffing requirements.
Education Link allows inmates to take advantage of several electronic learning initiatives while monitoring and reporting each inmate's progress so adjustments can be made, if necessary.
Our in-pod kiosk can be configured to allow inmates to access a variety of approved multimedia applications through a secure personal device. Offerings in the GTL entertainment portfolio provide access to the largest MP3/4, video, and e-book secure library available.
Introducing GTL Genesis to a facility provides an automated alternative to manual, behind-the-bars activities. In addition, the GTL Genesis provides the opportunity to introduce new interactive technologies that help inmates manage their incarcerated time.


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Kyokushin Karate Dojo Kun (Oath)
We will train our hearts and bodies for a firm unshaking spirit.
We will pursue the true meaning of the martial way so that in time our senses may be alert.
With true vigor, we will seek to cultivate a spirit of self-denial.
We will observe the rules of courtesy, respect our superiors and refrain from violence.
We will follow our spiritual path and never forget the true virtue of humility.
We will look upwards to wisdom and strength not seeking other desires.
All our lives, through the discipline of karate, we will seek to fulfill the true meaning of the way.
Dojo Kun in Japanese
Hitotsu, ware ware wa, shinshin o renmashi, kak-ko fubatsu no shingi o kiwameru koto.
Hitotsu, ware ware wa, bu no shinzui o kiwame, ki ni hasshi, kan ni bin naru koto.
Hitotsu, ware ware wa, shitsujitsu goken o mot-te, jiko no seishin o kanyo suru koto.
Hitotsu, ware ware wa, reisetsu o omonji, sobo no furumai o tsutsushimu koto.
Hitotsu, ware ware wa, shinbutsu o totobi, kenjo no bitoku o wasurezaru koto.
Hitotsu, ware ware wa, chisei to tairyoku to o kojo sase, koto ni nozonde ayamatazaru koto.
Hitotsu, ware ware wa, shogai no shugyo o karate no michi ni tsuji, Kyokushin no michi o mat-to suro koto.


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Corporate Website – Pricing Plans:
Order process described:
1. Choose a plan from the below list (Decide whether you will use your own domain or not)
2. Order and pay the plan
3. We will ask you (via email) questions related to the website setup, please answer them.
4. We do the website setup and when we finish we will send you the login information
5. You can start managing your own website
6. When you are done with the website setup you can show your new website to your customers
!!! Notes:
– Setup Fee
Why we charge a setup fee and what is included?:
1. Setup chosen Theme
2. Create username and add it as moderator/administrator to your website (administrator is only available in Own Domain installations)
3. Setup your information for the store
– Redirect Your Domain to Follol.com
Prices in this case are lower because of the less licenses we need to pay compared to Own Domain.
What exactly is domain redirection: Client needs to setup 301 permanent domain redirection from his domain control panel which leads to his Follol.com URL.
Example: borovprashec.com is leading to https://www.follol.com/borovprashec/
If you prefer your own domain name without redirection please use Own Domain
– Own Domain (Own Installation) (more info here)
Client can choose to use his own domain without redirecting to Follol.com. In this case extra charges apply for setup, aslo the client will have to pay for any extra software licenses he may need. Please contact us for more info.
– Bandwidth
2 000 MB / month – Enough for 1000 page visits per month on an average web site
5 000 MB / month – Enough for 2500 page visits per month on an average web site
25 000 MB / month – Enough for 12 500 page visits per month on an average web site
100 000 MB / month – Enough for 50 000 page visits per month on an average web site
! Each web site has different content. The estimation above is made on an average web site page size.
– New Language Version – 20% DISCOUNT
One web site package can serve only one language version.
If you need another language version you will need to purchase another web site package.
Here you can find the Additional Language Version plans.
We understand that it will double your expenses, but it will also double our resources usage.
Anyway we have decided to give you a discount if you order another language version of your web site.
Please contact our Customer Support / Sales team if you have any questions or concerns.
– Responsive design
Can open the web site on Phone, Tablet, Laptop or Desktop
– Software Updates
All sites' software will be up to date with newest bug fixes.
We decide when and which updates to apply and when to have downtime.
!!! VAT Notice:
All prices exclude VAT unless otherwise noted!
Regarding EU VAT regulations:
– Clients with billing address from Bulgaria will BE charged with extra VAT fee.
– Clients with billing address inside the European Union and without having a valid VAT number will BE charged with extra VAT fee.
– Clients with billing address outside the European Union will NOT BE charged with extra VAT fee.


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Internet Not Working Properly - Several Viruses
It runs on Windows XP. Common problem! Once you have identified any type of anti-virus, anti-spyware, or firewall software running, start by disabling the software altogether. Note: Additionally, you can upgrade the routers firmware to the latest version. http://esecurelive.com/internet-connection/internet-not-working-in-my-test-lab.html
At the top right corner of the main window, click the 'wrench' icon. October 9, 2012 spike @Angel Marrero: That's way to little detail to actually help. See more Connected to wifi but cant access internet Can't get internet on computer Www.wifi connected but no internet access .com WRT54G Won't Set Up/Access Internet Wireless Internet connected but browser Helpful +9 Report James Lane Feb 1, 2009 at 10:37 PM To get the internet to work while switching to XP from Vista on a newer Toshiba laptop, download Atheros AR5006X https://www.pcrisk.com/computer-technician-blog/general-information/7022-how-to-remove-virus-no-internet-access
Internet Connection Problem
I've called automated cable help services that tell me that they DO have an outage in my area, that was just after talking to a Live internet service rep. WinSockFix is an incredibly useful tool that deserves a special mention here because it specifically locates network-related registry entries and attempts to fix them. With… Develop Good Computer Security Habits Passwords are the key to virtually everything online today, so… Create Secure Passwords Computer security tips are important to follow. I've also tried System Restore after I removed the virus, and selected a restoration point of a day before the virus came through.
January 25, 2011 David Purcell Need more info….It looks like you're using a USB wifi card? If you cannot access the Internet due to a malware infection, first try booting your computer in Safe Mode with Networking. Some cheap routers may need power cycled sometimes (maybe as often as weekly - but in this range you should buy a new router), but they should never need reset, especially Virus Blocking Internet Windows 10 More» More Stories by John R.
In the opened window, click the 'Properties' button. 7. Is the Link/Act light on and constant? The only protection I have in my pc is ESET Antivirus. http://www.pcmag.com/article2/0,2817,2498672,00.asp this includes firefox internet explorer and chrome how can i make them run?i have checked my wireless connection to make sure it is functioning properly.
Turn Off Firewall/Anti-Virus Programs This is another really common cause for Internet connection problems. Wireless Internet Connection Problems that informed me that the problem I had was with my router. I tried EVERYTHING. If you have a device that does not support stricter encryption standards like WPA2, you might have to lower the security settings so that the device can connect.
Virus Blocking Internet Connection
email me anything responses at Email Id removed for security or just respond. http://ccm.net/forum/affich-16982-can-t-access-internet-wireless-working Read some helpful tips for contributing content to this site. Internet Connection Problem More often, however, malicious software such as spyware will inject its own proxy settings without the user being aware. Internet Connection Problems Windows 10 October 10, 2012 bill marden my internet conection keeps dropping , BT have been trying to sort it out now for 6months ,i havent allways had this problem .
It'll say things like "Not Connected" "Acquiring network address" etc etc. his comment is here If the test is successful, you'll see timed results. October 9, 2012 Dano I've noticed that most of the time when people are having issues, it's because even though they are successfully joining the wireless network, they are not acquiring If you see packet loss (in other words, if the web server didn't respond to one or more of the packets you sent), this can indicate a network problem. Internet Connection Problems Windows 7
If there are still problems phone your ISP and ask them to help with your modem. TURN OFF THE POWER to you computer, modem and anything else that is connected to your computer. Is the Link/Act light on and constant? this contact form Device Drivers: re-install network device drivers (Windows) At this point we have ruled out most of the common software issues that you are likely to ever see.
Note that if you have multiple adapters connected like Ethernet and Wi-Fi, you should disconnect one as having both connected at the same time shouldn't necessarily cause any problems, but sometimes Your Internet Access Is Blocked Chrome if bt cant fix this problem who can , eny ideas plz bill October 10, 2012 John I have an issue where my securely-set up wireless network is no longer recognized June 7, 2014 Top Rated Recent Popular Recent Find us on Facebook Contact Us Privacy Policy Terms of Use Sitemap Featured Posts Copyright © 2017 PCTechBytes Search Sign Up Log In
Let's go through some possible solutions.
Rajnish P Sinha Hi it worked for me. If there are no lights at all, the router is probably unplugged or powered down. Wait a few minutes before rebooting the router. How To Fix Internet Router The whole problem didn't start until I got that Antivirus Pro 2010 virus on my computer.
The manual way to install the driver is to first remove the existing driver configuration. Check the routers configuration for high-security firewall settings. Pranab Kumar Das Gupta & Ramprosad MondalPublisherS. navigate here I am open to try almost anything to regain the shortcuts.
I didnt know that malwares such as this could exists. Right-click your connections and select "Diagnose." It might state there is a damaged Winsock and attempt repair it. Some laptops have physical switches that let you turn off the wireless functionality. Report ecej- Dec 19, 2012 at 06:27 PM hello my set up are ok obtain the ip and dsn are high lighted but still I couldnt connect to internet Report ecej-
Although I couldn't connect to the internet on that certain computer, my connection would always be excellent. Some AV (Eg. In the opened window, click 'View network status and stats'. 5. Thanks again, Nick October 20, 2012 Dr.
I like to ping 126.96.36.199 because it's an easy address to remember. Copyright © 2006-2017 How-To Geek, LLC All Rights Reserved


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Eye of the SwarmEdit
When Sarlena awoke, she found herself laying on a bed with all her clothes on and attended to by several members of the crew, including guards. "She's awake."
"Well then what are we waiting for! Let's get her to the trial!"
Sarlena's mind was still on slow as she murmured with a yawn, "what trial?"
The crew member looked at her incredulously. "You're kidding me, right? About Michael's attempted murder against you? Or have you forgot it already?"
Sarlena bolted upright and snarled at them. She did Not want to be reminded of that heart-stopping experience. "Fine then, lead the way," she said, getting out of bed to follow them.
The trial room was already filled with several people, all dour-looking and very serious about the unfolding case. Michael was bound in one corner of the room, still wailing endlessly about how he had failed to exact the dead girl's vengeance by not having killed Sarlena earlier. There was no doubt about the guilt here.
But there was no doubt about the man's insanity either.
"Order in the court! Order in the court!" pronounced Daniel. "All right, I don't have a JD, but we're in the midst of a war, so let's get this over with as quickly as possible. Michael obviously can't plead either way. So it stands, for you, Sarlena, to decide whether he did what he did intentionally or otherwise. I have already prepared two sets cards holding what the rest of us have voted on will be the sentence, whichever way you choose. Please choose quickly." He held up two miniature envelopes, one with the words "intentional" and one with the words "insanity".
It was not a hard choice for Sarlena to make, for it was the truth, after all. And besides, it was not up to her to determine the verdict; whatever was in the envelopes would determine the outcome. So she quickly replied, "insanity."
"All right then, the vote for both of them is either death or life imprisonment," said James, taking the latter envelope and opening it. The others had already voted. Perhaps for his death, perhaps not. Perhaps for the pleading she chose for him, there would be at least one who did not wish for Michael to die. As everyone peered over to watch, he extracted a pile of folded pieces of paper, and unfolded them one by one. "Death." Next: "Death." "Death. Death. Death....."
Everyone in the room looked at everyone else in silent understanding as the votes continued to be read out loud. There was not a single dissenting vote. And that was for the lesser punishment...
"But... why?" asked Sarlena, stricken by being held responsible for the death of a one-time friend, yet knowing that both choices would have resulted in the same result.
James answered for the others with his intuition, "This latest event has finally shown us how much suffering Michael has undergone in the past several months. There has been not the slightest sign of recovery, and there is no light at the end of the proverbial tunnel. Therefore, in order to spare him of his misery, we have decided that a quick and painless execution is most fitting. Am I right?"
Grim, deathly nods from the officials arrayed around them.
"Sarlena, you will be escorted back to your room. Do get some sleep. You have been through too much already today, and I would hate to see the fate that befell Michael also consume you." He stood up at last, tapping his gavel one last time. "Case closed." Sarlena closed her eyes, remembering with sorrow and grief that the Michael before her was not, had not been, the friendly Michael she had known so long ago. It seemed entirely so surreal, that she didn't know what she should be thinking about it all. And yet... was she so heartless?
A few minutes later, when Michael had been put soundly to sleep, euthanasia was administered.
Daniel was awake yet nearly impossibly sleepy - he had slept no more than an hour the previous night - when the unwelcome barrage from the Overmind returned.
<Do you now see our power? The might of the Swarm is eternal; not even power a thousand times greater than your greatest of weaponry can harm the Overmind a whit. All the Protoss forces on Aiur have fallen like a row of dominoes. And we have access to Xel'Nagan technologies that the Protoss never even dreamed of. Do you now see the wisdom of siding with the Swarm?>
Daniel restrained the urge to spit in the operations center. <Humph. And do you not think that we too have secrets that you have never dreamed of? I will KILL you today.>
Then he touched the Khaydarin amulet he bore, and instantly the Overmind's haughty reply was banished.
I've had enough of that beast.
He turned to look at the hologram, which showed the continual progression of the Zerg. The Protoss had managed to evacuate their battered Stargates from the system, and the Khalai that had been on the planet had all been safely evacuated, but that could not right the fact that nearly all of Aiur was now Zerg territory, and that there would be little left of Firstborn civilization on the planet at all within minutes. Very few pylons remained functional on the planet.
Aboard Heart of the Conclave, the first of the Motherships, the most respected of Judicators came together one more time in a pristine, golden rotunda. Seats were placed about the walls, while a large, giant, flawless crystal of Khaydarin hovered in the middle, radiating a soft, tranquil blue glow. Arranged around the circular room like windows were viewscreens depicting the battle raging across the system.
Judicator Aldaris began. <We have all seen the destruction of numerous Cerebrates, and the ensuing total deadness of their two broods, the minions of which have all died from a breakdown of homeostasis. We know very well that these few dark ones alone have been responsible for more kills than half of all the Fleets of the Khala. And I remember very well what Zeratul had said to me: 'You speak of knowledge, Judicator? You speak of experience? I have journeyed through the darkness between the most distant stars. I have beheld the births of negative-suns and borne witness to the entropy of entire realities... Unto my experience, Aldaris, all that you've built here on Aiur is but a fleeting dream. A dream from which your precious Conclave shall awaken, finding themselves drowned in a greater nightmare.' Is it not best for us to acknowledge that maybe we are indeed not as perfect as a thousand years of the Khala has led us to believe?>
No protest, though all were pensive; the very silence seemed loud.
<Then let us make a lasting peace with Tassadar, Zeratul, and their stewards.> The Judicator reached out with his mind, and established a channel with one he once believed was his arch-enemy. <Tassadar. Zeratul. This comes too late to you. But the Conclave has witnessed your defeat of many a Cerebrate. They know now that they cannot deny the necessity or the effectiveness of your actions. We sought to punish you, while it was we who were in error. You represent what is greatest in us all, and all our hopes go with you. EN TARO ADUN, brave Sons of Aiur!>
Back aboard the Hyperion, Daniel smiled grimly. <Wow. Does that mean they're going to send some backup for us?>
<You know very well that the Conclave is but an empty shell now,> Zeratul stated flatly.
<We will return the Ganthrithor and the title of Executor to you. It is the least we can do,> Aldaris responded.
<Thank the Khala.> Tassadar communicated with Zeratul, < If I die killing the Overmind, only bring me back if I fail.>
< If that be your wish, as it is mine, then agreed. As an old friend, I make that request as well, that if I succeed, do not bring me back either, for I have realized what the endgame is. It seems quite apparent that the means the Xel'Naga were referring to involve the combination of two individuals into one.>
< I do too. The creation of an Archon?>
<Yes. The legendary feat that only Adun was able to do. Only this time, it will be different, for we truly know little about the Terran from our interactions with them. Do you think you will be able to manage?>
Tassadar's reply was adamant. < I have sacrificed all that our world might live. I have sullied my honor, I have discarded my rank and standing, and I have even broken our own most ancient traditions. But never think that I would, for one moment, regret my actions. For I am Templar, and above all else, I have sworn to protect our Homeworld 'till the end.>
<Then let us tell Daniel... no wait, we cannot.>
< Indeed, if we tell him what the true cost to him would be of killing the Overmind, he may think twice. And we cannot allow that to happen. He is, after all, human, and the Terran have never been Awakened, have never been able to put their all into a worthy goal to the extent that we and the Zerg are able to.>
<Then you should just tell him that he will be required for a ritual. That is all,> concluded Zeratul.
Tassadar called out to Daniel, <Daniel, you are needed for a ritual for destroying the Overmind. I will blink you aboard the Ganthrithor in a few seconds.>
Just as Daniel tried to understand this, a polarion beam, invisible to the naked eye, passed through him, scanning him, uploading everything there was to know about him into the Protoss data banks.
Daniel turned to James. "I will be aboard Tassadar's Carrier soon. Congratulations, James. With Sarlena... out of the picture... I promote you to rear admiral. You will be responsible for running our fleet and preparing for the final showdown..." Before the awestruck James had any time to react, a miniature portal spirited Daniel away to the flagship Ganthrithor.
"So... what happens now?" asked another officer.
"Daniel's going to do what he can to win this war, even if it means leaving his own fleet. For now, I'm in charge. Just so you know, the battle's about to end soon one way or another, and I'm determined for it to end in our favor, even if it means sacrificing the Harbinger Fleet. You can be sure that I will do whatever it takes to bring us victory today."
Everyone in the room immediately tensed up, and James knew enough about these people to know why. "The Hyperion is not slated for such a fate," he declared, and immediately they all relaxed, even though they then tried to hide it from his eyes.
He saw it, and immediately became filled with rage. "Why you!.!. You care only about your own skins, and don't care if any- and everyone else dies in your place! OWW!--" he roared in frustration as he pulled a tendon in his jaw. "You bunch of..."
"Calm down, James," said Ariel, unperturbed. "There's a reason we - that is, the crew of this ship - have managed to live for so long in so hostile an environment. We're commanders, not martyrs. We're not stupid." Like Christopher, she wanted to add, but shut her mouth at the last moment.
"And Daniel's stupid too?" challenged James.
Ariel remained pacific. "I can promise you, that they will see to it that Daniel comes to no harm; he is merely required for a ritual, that is all."
The Overmind was cloaked in the black night; only the occasional cloud cover reflected any light from the occluded sun, their undersides a dark shade of red. Red from fire, blood, and destruction. The surface was entirely pitch; naught could be seen, as nothing gave off a glow here the way they did in Terran cities. Its furthest tendrils had, despite being time-bombed most of the time, already crept up the stairs of the Temple of Knowledge, working its way up to the final floor.
The hated Overmind, thought Daniel.
Tassadar gave his prepared speech to the remaining Protoss. <My friends, this is our final hour. Not all of us may survive the coming conflict. Yet, death may be a blessing should we fail here. We seek now to destroy a foe that has ravaged its way across the universe consuming all in its path. And now it has reached the end of its long journey. The Overmind has come to destroy all that we hold dear and assimilate us, and all knowledge, unto itself. And I say to thee, this shall not come to pass! Aiur shall not fall! As Executor, I stand ready!>
Daniel added, <As do I.>
Zeratul turned to the fleet of Warp Rays the Protoss had just minutes earlier constructed. <This is our time of glory. For now, we shall attempt to destroy that which we have pledged to destroy for centuries. Today, we are Templar! En Taro Adun!>
As the entire contingent of Protoss in that fleet began a wild psionic cheer, the Warp Rays as well as countless other starships - the Final Fleet - broke apart from the main bulk of the Protoss fleet and began moving toward the well-protected Overmind on the planetary surface. By now the Zerg Swarm had already slaughtered most of the leaderless broods, and had turned their attention back on the Protoss. The Homeworld Fleet began to suffer massive casualties once again.
The Final Fleet blinked all the way down to near the surface of the planet, right next to the Overmind, taking a sphere formation with the Ganthrithor and the Warp Rays in the center. That same instant the two forces, each billions upon billions of vessels strong, clashed, initiating yet another titanic battle.
The Guardians' shields held back the brown tide only momentarily before they too collapsed from the stress of too many Zerg sacrificing themselves in too short a span of time. Now left incredibly vulnerable, they were left shattered hulks, some even entirely missing from this reality, as waves of scourge slammed into them, knocking them out of the timestream. In turn, these scourge were obliterated by the interceptor cloud, their photon torpedoes easily hunting down their targets. But there were simply too many of them, and the dracolisks soon had mopped up all the interceptors through sheer numbers. Even the raw destructive force of the Needleships' ion cannons weren't enough; they could only slash in their narrow beam. It was like trying to stab every ant on the anthill with a pin - no matter how precise one could get with the aiming, it would simply take too much time to clean out the approaching swarm. And time they did not have, as the giant floating crabs - the cancerlisks - spurted out their highly destructive plasma balls, breaking through the Needleships' armor like they were nothing, and quickly pulverizing them into golden specks and shards. Dreadnoughts continued to shoot phase disruptors into the most concentrated areas of the swarm, hoping to score quick victories as their deleterious effects jumped from target to adjacent target but more often being simply destroyed before they could activate. Anemonelisks continually sacrificed their extensive pinkish tentacles absorbing enemy fire while the rest of the swarms continued to advance. Within moments the spider-like arachlisks had released massive, kilometer-scale webbing to entangle the Protoss vessels, preventing them from taking evasive maneuvers. Very quickly the two sides succumbed to each others' fire. Before any of the Warp Rays had caused enough of a feedback loop to harm the Overmind, they had all been destroyed, every one of them.
Then there were those which fought not with destruction. The Zerg had their damselisks, spreading purplish-black nanite plumes all over the Protoss interceptors where vicious microscale battles waged for control of their systems; many an interceptor turned against their own Carriers, unleashing a fierce bombardment in addition to that of the swarm. Motherships continued to flash their golden beams throughout the alien clusters, anything they touched quickly being subverted by the superior nanites of the Protoss. As a downpour of the Zerg nanite weaponry continued to pound on them, the Motherships quickly became pock-marked with holes. Then they would phase-shift, temporarily vanishing from this plane while they were swiftly reconstructed and restored back to prime condition. Then they would return, to continue on. But eventually the phase-shift devices on each of the Motherships was breached before they could activate, and then it was only a matter of seconds before they were destroyed, never to be regenerated.
Such a great cataclysm, so that a single ritual could proceed safely within the spherical formation of the golden fleet.
The flagship Ganthrithor was set on a crash course directly for the Overmind. On board the nearly hollowed out central portion of the Ganthrithor, Tassadar and Daniel stood in the center of the large, beautifully kaleidoscopic chamber, bluish wisps slowly emanating from the High Templar's body as the ritual Archon Meld began. Despite all the reassurances Tealdarin and Zeratul had given him, Daniel still felt unnatural amounts of fear creep upon him.
The light he produced only became more and more intense, the psionic signature more and more potent. Then the critical point had been reached; Tassadar flung his limbs over his head; the three nerve cords at the back of his head twisted together; and suddenly all of the carrier was eclipsed by the static from a sphere of living psionic potential that had replaced the two representatives of separate races.
An Archon.
<Tassadar was right, Daniel IS touched by the power of Xel'Nagan creation,> noted Zeratul as he and others watched the scene unfold from their own starships. <And what a fine one he is too.>
The building energies soon surpassed the size of the Carrier, vaporizing it in the process. The pulsing twilight star lit up the obsidian night sky, a single inextinguishable light in the midst of endless chaos, radiantly bluish-white, as it finished its plunge into the Overmind before it, seeing its doom swiftly approaching, could attempt to transplant itself on a different planet.
The Archon had one final demand to make. <Remember us, Conclave. Remember what was done here today. May Adun watch over you.> *
<En Taro Tassadar,> came the reply.
There was a transient psionic shockwave so strong it took all Protoss in the galaxy into a coma for an entire day thereafter, that destroyed all instruments designed to measure influences along that plane. It was one so powerful that it swept through the thousands of Zerg that had gotten in its way attempting to sacrifice themselves to save their master; and - most importantly - plowed through and obliterated the immunity that had kept the Overmind immortal for so long.
Then the entire Overmind, the Eye of the Swarm vaporized in a heartbeat as the incredible power of the Archon erupted over its iris simultaneously.
The Protoss may be put into a long coma, but the Zerg were dead.


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From July 30th to August 4th, prepare to have a wonderful time at the Goshen Country Fair!
Located 3 miles east of West Chester, at the intersection of West Chester Pike (Route 3) and Ellis Lane.
There will be games of chance, amusement rides and delicious food (including their world famous (or at least locally famous) donuts!
You can enter the Agriculture & Family Living Contests or visit the dairy cow, sheep, goat, rabbit and poultry exhibits. You can dance, you can play bingo or you could just walk around and watch everyone having a great time.
My personal favorite is the pizza.
Hope to see you there!


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Comments:28.03.2017 at 11:06 Tom:
Lost labour.


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GeneRank: Using search engine technology for the analysis of microarray experiments
Interpretation of simple microarray experiments is usually based on the fold-change of gene expression between a reference and a "treated" sample where the treatment can be of many types from drug exposure to genetic variation. Interpretation of the results usually combines lists of differentially expressed genes with previous knowledge about their biological function. Here we evaluate a method – based on the PageRank algorithm employed by the popular search engine Google – that tries to automate some of this procedure to generate prioritized gene lists by exploiting biological background information.
GeneRank is an intuitive modification of PageRank that maintains many of its mathematical properties. It combines gene expression information with a network structure derived from gene annotations (gene ontologies) or expression profile correlations. Using both simulated and real data we find that the algorithm offers an improved ranking of genes compared to pure expression change rankings.
Our modification of the PageRank algorithm provides an alternative method of evaluating microarray experimental results which combines prior knowledge about the underlying network. GeneRank offers an improvement compared to assessing the importance of a gene based on its experimentally observed fold-change alone and may be used as a basis for further analytical developments.
Since its launch in 1998, the Google search engine has all but monopolized page searches on the world-wide web
Just as the original PageRank is stable against the artificial inflation of a web page's rank by web designers, we hope that GeneRank may obtain a more robust ranking of genes in (typically very noisy
Data sharing techniques have been successfully implemented previously using, for example, GO annotations
Our aim in this work is to use connectivity data to produce a prioritization of the genes in a microarray experiment that is less susceptible to variation caused by experimental noise than one based on expression levels alone. This is achieved using GeneRank, a customised version of the PageRank algorithm.
Results and discussion
The algorithm
The algorithm on which we base our method of microarray experiment analysis was originally devised for assessing the importance of web pages in search engine results. We show here that its formulation allows for a simple and intuitive extension for our application. The PageRank algorithm, used by the successful search engine Google
Figure 1
The Vote of Confidence Principle
The Vote of Confidence Principle. Just as a the PageRank of a web page will be high if it is linked to other highly ranked pages, we hope that the relative ranking of a gene will be increased if it is linked to other highly differentially expressed genes.
The original PageRank algorithm also has a random walk interpretation where the ranks correspond to the invariant measure of a teleporting random walk on the web. This is equivalent to saying that the rank of a web page is proportional to the time spent at the web page whilst surfing the web. This idea can also be intuitively extended to ranking genes, where the rank of a gene is proportional to the amount of time a biologist should spend looking at a gene whilst analysing the experimental results.
As with the original algorithm, we require a network or graph to allow us to calculate a rank for each entity in the network. With the original algorithm, nodes represent web pages and a link exists between two nodes if one page contains a hyperlink to the other. This results in a directed graph. In our case, we define an undirected graph where a node represents a gene and the edges can be defined by some other "previous knowledge". For our purpose, we use either Gene Ontology annotations
For each gene, the expression level vector contains the value for its expression change in the experiment under consideration. The algorithm, GeneRank, also uses a free parameter,
In addition to the gene expression data, GeneRank uses a network or graph as input. We use the absolute value (the algorithm requires positive expression change values) of the gene expression data as a weight for each node in the graph and define the network connectivity by some other criterion. We use either Gene Ontology annotations or correlation coefficients, but there are many other possibilities, e.g., metabolic networks, transcription factor networks, or protein-protein interactions. We also used synthetic networks with controlled topological features for evaluation purposes. The three types of network were constructed as follows.
GO networks
Genes are connected if they share an annotation defined by the Gene Ontology. This defines three networks, one for each of the GO sections; Biological Process, Cellular Component and Molecular Function. We do not use the acyclic directed graph associated with the Gene Ontology, but assign leaf nodes as the annotations for each gene. A yeast diauxic shift experiment
Table 1
Network Parameters
Network Parameters
Synthetic Network 1
Synthetic Network 2
Synthetic Network 3
Biological Process
Cellular Component
Molecular Function
Correlation Coefficient
Correlation coefficient networks
A yeast stress data set consisting of 156 microarray experiments under a wide range of stress conditions was used to construct these networks. This data set is discussed in
Synthetic networks
To allow control over the network structure, synthetic networks were defined with 1000 genes. The genes were split into two sets,
Synthetic network 1 is the standard case with equal expected degree across both sets and |
To justify drawing the expression levels for sets
Figure 2
Testing the algorithm
Synthetic networks
Since we are trying to improve the ranking of genes produced in microarray experiment, we need to quantify the quality of the ranking produced by the algorithm. In the case of synthetic data, we know that all genes in set
The construction of synthetic networks allows us to obtain full control over the network structure. We experimented with various network parameters.
Relative connectivity and expression-connectivity weighting
We measure the relative connectivity as
Relative expected degree
We carried out a number of tests where
Figure 3
Varying the relative expected degree between sets
Varying the relative expected degree between sets
A number of observations can be made from the experimental results where
• The maximum AUC achieved by the algorithm increases as the difference between
• As the difference between
• The maximum AUC achieved in each case occurs at larger values of
• The improvement by the algorithm over expression change ranking is greater when the difference between the expected degree of both sets is greater.
To summarise these findings, a higher expected degree of set
Relative set size
Four cases were investigated, where |
Figure 4
Varying the relative sizes of sets
Varying the relative sizes of sets
These results on synthetic networks suggest that for certain network structures GeneRank can achieve a significant improvement over ranking based on pure differential expression. The relative expected degree of sets
However, in our tests the quality of the results generally decreases for values of
GO networks
As described earlier, we construct the GO networks by defining an edge between two genes if they share an annotation allocated by the Gene Ontology Consortium. This allows us to construct three networks, one for each section defined by the Gene Ontology: Biological Process, Cellular Component and Molecular Function.
An initial test combined the real network connectivity with synthetic expression changes. We ordered the genes based on expression change in the yeast diauxic shift experiment and allocated the top 300 down-regulated genes to set
Figure 5
Combining real connectivity with synthetic expression
Combining real connectivity with synthetic expression. The network connectivity for each of the three GO networks: Biological Process, Cellular Component and Molecular Function were combined with synthetic expression data. In each case, the 300 most down-regulated genes which were defined using the real yeast diauxic shift data were allocated expression from a
To check if GeneRank produces a gene ranking which is robust to noise we conducted a further experiment using the GO networks. Real experimental data were used throughout. The Cellular Component network was used in this experiment. For each of the top 200 genes sorted by differential expression, we set its expression change to 0 in turn (i.e., defined it as "unchanged") and determined if the GeneRank algorithm was able to pick up this anomaly and consequently move the gene towards its original place in the ranked list. The premise here is that its connections to other highly changed genes will boost the artificially altered gene in the ranking. The same experiment was done for 200 randomly selected genes. The results are given in Figure
Figure 6
GO networks: testing the 'boosting' ability of the algorithm
GO networks: testing the 'boosting' ability of the algorithm. An experiment was carried out to assess how well the algorithm is able to increase the relative ranking of a gene based on its connections to other highly changed genes. The top 200 most changed genes are set in turn to have a differential expression of 0. If the ranking were based on pure differential expression only, each gene would appear at the bottom of the list. By PageRanking, we raise the position of the gene closer to its original ranking. The same effect is not observed when a random 200 genes are chosen. The majority of these genes will not have connections to other highly changed genes. The blue line represents the original expression ranked position, the red circles show the original GeneRanked position and the blue asterisks show the modified GeneRanked position.
To quantify the results we calculated the quality index
where alt_PR is the GeneRanked position after the expression of the gene has been artificially altered, orig_exp_rank is the original expression-based position in the list, and alt_exp_rank is the expression-based position after the differential expression has been set to 0.
In the case where we are altering a gene in the top 200, a 'boosting' effect is observed and the ranked position after the fold-change has been moved towards the original ranked position. We can observe groups of genes which are boosted to the same level (shown by 'lines' of blue asterisks). It is likely that these genes are a completely connected subgraph, which results in all genes being given the same ranking. Altering genes which were originally ranked in the top 200, we achieve
Correlation coefficient networks
Using the correlation coefficient network defined by the stress data set
Figure 7
Correlation Coefficient networks: testing the 'boosting' ability of the algorithm
Correlation Coefficient networks: testing the 'boosting' ability of the algorithm. The same experiment as in Figure 6 was carried out on the correlation coefficient networks. In each case the network connectivity is identical but the expression change vector, used as input to the algorithm, is randomly chosen to be one experiment from the stress data set. The x-axis represents the top 200 genes when ranked using expression change information. We calculate a 'boosting' measure to quantify how much we increase the relative rank of each gene after it has been altered. In this case, each gene was changed to have expression change 1. The large values for
Again we calculate a value of our quality index
The purpose of this work was to explore the possibility of adapting the PageRank algorithm, used by Google in assessing the importance of web pages, for the task of prioritizing the 'importance' of genes in a microarray experiment. Our new algorithm, GeneRank, allows connectivity and expression data to be combined to produce a more robust and informed summary of an experiment, compared to the standard procedure of basing the importance of a gene on its measured expression change. Although we use expression change values as expression data, this is not restricted, and some other means of capturing the expression information may also be used. GeneRank can be justified theoretically and has been tested on synthetic data, experimental data and a combination of both. The algorithm has a single parameter,
While the improvement of gene rankings upon application of GeneRank is already significant in the examples presented, it may become even more so once comprehensive high-quality biological network information becomes available. Of particular interest in that respect will be transcriptional regulatory networks, such as are now being generated by technologies like ChIP-chip (see
The original algorithm
We summarize the basic PageRank algorithm which was developed by Larry Page and Sergey Brin at Stanford University
PageRank assigns a measure of relevance or importance to each web page, allowing Google to return high-quality pages in response to a user query. The algorithm is designed to be robust to methods of deception, where web page designers attempt to artificially boost the PageRank of their page by altering the local link structure. Robustness follows from the recursive nature of the algorithm, where a page is highly ranked if it is linked to by other highly ranked pages. A link from page
A random walk interpretation
The PageRanking process has an alternative interpretation in terms of a random walk
teleports: with probability 1 -
surfs: with probability
The PageRank vector r, when normalised so that its components sum to one, corresponds to the invariant measure for this process. In other words,
The modified algorithm: GeneRank
The PageRank idea translates intuitively to the analogous situation of gene expression analysis. Instead of producing a ranked list of web pages, we produce a ranked list of genes. PageRank views hyperlinks as votes of confidence, so we similarly allow functional connections to boost rank. Just as PageRank counts votes from a highly-ranked page as more influential than votes from a lowly-ranked page, we will allow connections to genes with high differential expression to carry greater significance than connections to genes with low differential expression. Figure
PageRank gives each web page a rank of (1 -
We remark that this iteration may also be motivated from the viewpoint of
The iteration (4) corresponds to Jacobi on the system
and, because the iteration matrix has not been altered, the condition that convergence is guaranteed for all 0 <
In summary, the GeneRank algorithm is finding the customised ranking vector r defined by the linear system (5). A Matlab implementation of the algorithm is available in the additional file geneRank.m The random walk interpretation carries through to this more general setting. If the teleporting step is re-defined so that the destination gene is not chosen uniformly over the whole set, but rather is chosen with probability proportional to absolute expression level, then r in (5), suitably scaled, is the invariant measure. Overall, we have a true generalization of PageRank in the sense that (a) the algorithm has both "vote of confidence" and "random walk" interpretations and (b) for the case where all ex
It is trivial to check that with the choice
and the system (5) for the corresponding fixed point becomes
First, we show that the sum of the rankings is preserved by the iteration. From (6),
Also, it is clear from (6) that the iteration preserves the nonnegativity of the initial ranks; that is,
Now, we observe that
So r* - deg/||deg||1 is an eigenvector of
Result If the eigenvalue λ = 1 of
Overall, we conclude that the extremal parameter values
ROC – Receiver Operating Characteristic
AUC – Area Under ROC Curve
GO – Gene Ontology
Authors' contributions
JLM implemented the algorithm, performed the experiments, and drafted the manuscript. RB provided biological datasets and interpretation, and participated in the experimental design. DRG contributed to study coordination and continuous discussions. DJH first conceived of the application of PageRanking to biological data, and participated in study design and supervision. All authors read and approved the final manuscript.
Additional File 1
The Matlab GeneRank implementation. The file contains a Matlab implementation of the GeneRank algorithm. The file requires a matrix describing the network connectivity and a vector of expression changes for each gene. The output is the vector of rankings for each gene.
Click here for file
Additional File 2
A Matlab .mat file containing sample GO networks and expression change vectors. This file can be loaded into Matlab using the command load G0_matrix. This will load three matrices (w_All, w_Up and w_Down) and three expression change vectors (expr_data, expr_dataUp and expr_dataDown) into the current workspace. These matrices were constructed using the all three sections of the Gene Ontology, where a link is present between two genes if they share a GO annotation. Only genes which are up-regulated are included in w_Up and only down-regulated in w_Down. The GeneRank algorithm should be used with the corresponding matrix and expression change vector, e.g. the command ranking = geneRank(w_Up, expr_dataUp,d) would be used to calculate the ranking of the up-regulated genes in the experiment.
Click here for file
JLM was supported by a Synergy scholarship, a jointly supervised studentship between the universities of Strathclyde and Glasgow.
RB was supported by a BBSRC grant (17/G17989) to Anna Amtmann and a personal research fellowship from the Caledonian Research Foundation..
DJH was supported by a Fellowship from the Royal Society of Edinburgh/Scottish Executive Education and Lifelong Learning Department and by the EPSRC grant GR/562383/01.
Deeper inside PageRank
The PageRank citation ranking: bringing order to the web
Vital statistics
Making sense of microarray data to classify cancer
Graph-based iterative Group Analysis enhances microarray interpretation
Discovering regulatory and signalling circuits in molecular interaction networks
Functional modules by relating protein interaction networks and gene expression
Protein network inference from multiple genomic data: a supervised approach
Protein Interaction Verification and Functional Annotation by Integrating Analysis of Genome-Scale Data
Gene Ontology
Exploring the metabolic and genetic control of gene expression on a genomic scale
Scaling exponents and clustering coefficients of a growing random network
Genomic expression programs in the response of yeast cells to environmental changes
Correlation Coefficient
Stanford Microarray Database
The area above the ordinal dominance graph and the area below the receiver operating characteristic graph
Use of receiver operating characteristic (ROC) analysis to evaluate sequence matching
Genome-wide location and function of DNA binding proteins
Genomic binding sites of the yeast cell-cycle transcription factors SBF and MBF
Complex transcriptional circuitry at the G1/S transition in Saccharomyces cerevisiae
The sleekest link algorithm
Google PageRank as mean playing time for pinball on the reverse web


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