text:
I have a data.txt file containing data like this
...house # johncar # smithboat # john...
I need to remove from file data.txt , all rows having "# john" . I can load the file in array because it's a very big file and I receive a memory error.Is there any way to remove all rows having "# john" in the file , without loading the file in array ?
Thank youGraziano
You will want to use fgets, write lines you want to keep to a new file, something like the below
$oldfile = fopen('mylargefile.txt', 'r');
$newfile = fopen('mynewlargefile.txt', 'w');
while (($currentLine = fgets($oldfile)) !== false)
if (strpos($currentLine, '# john') === false) // line did not contain # john
fwrite($newfile, $currentLine);
excellent way , thank you.


text:
It Is Time To Give Abhay A Hug Tank Top
Product Color:
Product information
The Tank Top It Is Time To Give Abhay A Hug is the no-sleeve version of the popular favorite t-shape, ladies style. Perfect for use in sports where you are bound to sweat and need wide range of movement as well as on hot and sunny days, to avoid those tan-lines across your biceps.
Put It Is Time To Give Abhay A Hug on the finest combed jersey which feels soothing against your skin. Abhay Tank Top is available in 10 different color options. Heather Grey: 80% Peruvian Cotton/20% Polyester. Remaining Colors: 100% Cotton.
Sku: TT1GR0000008721717170011BL0000000

subset: commoncrawl


text:
Officials confirm girl was run over by fire truck responding to airliner crash
SAN FRANCISCO — A little girl who was aboard the Asiana Airlines flight that crash-landed died Friday, the same day that authorities confirmed one of the two Chinese 16-year-olds killed in the disaster was hit by a firetruck.
The disclosure about the teen raised the tragic possibility that she could have survived the crash only to die in its chaotic aftermath.
No one knows yet whether the two teens lived through the initial impact at the San Francisco airport. But police and fire officials confirmed that Ye Meng Yuan was hit by a firetruck racing to extinguish the blazing Boeing 777.
Her close friend Wang Linjia was among a group of passengers who did not get immediate medical help. Rescuers did not spot her until 14 minutes after the crash.
The other little girl died Friday morning. San Francisco General Hospital said she had been in critical condition since arriving Saturday after the accident. Officials did not identify the girl at the request of her parents. Her age was also withheld.
Meng Yuan's body was found covered in firefighting foam near a seawall at the edge of the runway, along with three flight attendants who were flung onto the tarmac while still buckled in their seats. Meng Yuan was not in her seat.
"The firetruck did go over the victim at least one time. Now the other question is what was the cause of death?" police spokesman Albie Esparza said. "That's what we are trying to determine."
San Mateo County Coroner Robert Foucrault said the results of his initial inquiry into the deaths would likely be released sometime next week. He would not comment on the police investigation.
Moments after the July 6 crash, while rescuers tried to help passengers near the burning fuselage, Wang Linjia and the flight attendants lay in the rubble almost 2,000 feet away. A group of survivors called 911 and tried to help them.
Members of the group — martial arts athletes and their families returning from a competition in South Korea — said that after escaping the plane, they sat with at least four victims who appeared to be seriously hurt. They believe one of them was one of the girls who died.
Cindy Stone, who was in that group, was recorded by California Highway Patrol dispatchers calling in for help: "There are no ambulances here. We've been on the ground 20 minutes. There are people lying on the tarmac with critical injuries, head injuries. We're almost losing a woman here. We're trying to keep her alive."
San Francisco Fire Department spokeswoman Mindy Talmadge said Friday that when airport personnel reached the group near the seawall, Linjia was dead.


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Anger at students' Hitler drinking game
The community has spoken of its outrage after almost 12,000 students joined a Facebook group promoting a drinking game which encourages participants to mock the Holocaust and dress up as Hitler.
Students at Huddersfield University allegedly created Hitler – The Drinking Game, which involves laying out cards in a swastika shape and members impersonating Hitler.
Each card carries a different meaning, including the "Hitler Card" where the person who draws the card "becomes Hitler" and other plays must refer to him as Hitler or Mein Fuhrer and the "Heil Hitler" card where the players must salute until somebody forfeits and must do a shot.
Creators of the Facebook group, which has since been shut down, called themselves "Fuhrers", according to the Press Association.
According to PA, Professor Peter Slee, deputy vice-chancellor at the university, said inquiries would be made into the involvement of the students with the group.
He said: "We are shocked to hear about this game, and extremely disturbed at the allegations that students at this university have been taking part in it.
"This is a highly unusual incident and the university prides itself on its multi-cultural, cohesive campus.
"We will be investigating these allegations, which we take very seriously, and will take appropriate action once these investigations are complete."
Another group, Hitler Drinking Game, has since been set up by with more than 5,000 members.
Carly McKenzie, UJS campaigns director, said: "It's a disgusting actions against an abhorrent historical event. Holocaust Memorial Day is just days away and this is a demonstration of the fact there is still so much work to be done on education.
"It's a huge issue for this country if students – the leaders of tomorrow – are doing Heil Hitlers and making a mockery of a horrific point in history."
Mark Gardner, of the Community Security Trust, said: "It would be easy to dismiss this as a stupid and offensive student stunt, but it is absolutely shocking that 12,000 people should have joined the Facebook group.
"This is another example of how electronic media is facilitating and normalising hatred. We welcome the university's proposed investigation."
- Writer who uncovered troll hit by online antisemitism
Writer who uncovered troll hit by online antisemitism
- Hundreds of thousands view Holocaust denial talk
Hundreds of thousands view Holocaust denial talk
- Dublin to fly Palestinian flag
Dublin to fly Palestinian flag
- Swiss to vote on kosher meat import ban
Swiss to vote on kosher meat import ban
- Ex-JFS student makes history on Dragons' Den
Ex-JFS student makes history on Dragons' Den
- Jewish mum in Great British Bake-Off
Jewish mum in Great British Bake-Off
- Couple to take civil partnership case to Supreme Court
Couple to take civil partnership case to Supreme Court


text:
NEW guidance has been issued on what the new Common Agricultural Policy (CAP) greening rules will mean for English farmers.
CAP is the £15billion policy implemented at EU level which sets out rules for what farmers can produce and how.
The information aims to be as simple and flexible as possible.
Under the new Basic Payment Scheme, greening will account for around 30 per cent of claimants' direct payments.
There is a new online service called the CAP Information Service, available on gov.uk
This will be used to apply all new CAP schemes and to help keep track of payments.
Farmers have raised concerns about the impact of the new greening criteria and three-crop rule on their businesses.
The three-crop rule states that if a farmer has 10 or more hectares of arable land, they have to follow crop diversification rules to continue to receive the full greening payment.
The government has said it does not want farmers to be adversely affected and that three crops can be grown over the course of a year.
A two-month inspection window of May to June has been set for the five per cent of farms that will be inspected. This should cover the majority of crops in England.
Environment Secretary Elizabeth Truss said: "I will press the Commission for increased clarity and flexibility on greening, including a review of the three-crop rule.
"I will champion the interest of our farmers so they can continue to produce top-quality, world-class food."


text:
Trista Footstool
100 0
false pdp {"scheme":"product1_cr"}
false pdp {"scheme":"product2_cr"}
Trista Footstool is rated out of 5 by 119.
Rated 5 out of 5 by jlok from perfect size and shape
Date published: 2016-09-13
Rated 5 out of 5 by PT53 from Great Footstool The Trista Footstool is a great addition to my small reading room ...not big and bulky, but very compact...just the right size! I bought one for my mom, to use with her rocker. Great colors!
Date published: 2015-06-30
Rated 5 out of 5 by CBNJ from Exactly what I was looking for I bought 2 footstools to use in our family room to use as footrests & sit on @ a coffee table. They are the perfect size & fit under the table when not in use. They are made very well & I actually ordered another one to use in another room.
Date published: 2014-12-09
Rated 5 out of 5 by Annatty1 from Absolutely adorable These little ottomans look great under my glass coffee table. In fact they look so good, I ordered another two so that I will have ottomans in every corner under the coffee table. Since I just received them, I can't comment on quality or durability,.but they look great. Also, each was packaged inside a muslin protective cover.
Date published: 2017-01-24
Rated 5 out of 5 by KathrynM from Good looks and quality... This is the 2nd Trista Triangle Leather Ottoman that I have purchased. The color choices are bold, it looks great, and the quality is very good. The nailhead trim really conveys the look I want. The size is small enough that the ottoman is not in the way when walking by or vaccuming. Other ottomans are large and often too high.
Date published: 2014-03-06
Rated 5 out of 5 by MarkS from Nice Ottoman This ottoman is well built and looks beautiful. The ottoman was very well packed and was dilevered in perfect condition. When you are ordering your ottoman make sure to break out a ruler so that you get a true sense of the size. They are small but that is exactly what I wanted for my low couch. I would definately recommend buying this product.
Date published: 2013-05-18
Rated 5 out of 5 by Lindax2 from Love them I have rec'd so many complements on how beautiful these are. They make the room pop!
Date published: 2014-10-08
Rated 5 out of 5 by KBCalifornia from Absolutely gorgeous I wanted a stool to have near my coffee table/fireplace; thought it would be nice to be able to sit on it near the fire place or when using the coffee table to play board games. These are so beautiful! My coffee table is glass top and round with 4 quadrants underneath; turns out this wedge tucks in the quadrant completely out of the way when I am not using it and it looks very pretty through the glass. I have 2 and I think I will have to get 2 more for the remaining quadrants (though I'd actually prefer to find a nice triangular basket but no success so far.# The size is perfect -- not too small #which would make it uncomfortable and unstable#; not too big #which would make it take up too much space.) Comfort-wise, it is very firm! My bottom would have loved it to be a little cushier but this way the leather keeps its shape better. It's fine for short periods of time.
Date published: 2015-11-14
What is the dimention in inches of the three sides.
The footstool curves on the three sides and the three sides measure 17".
Date published: 2016-11-12
Does the Textured Sky Blue of the Trista Footstool match the TSB of the Bella Chair?
Thank you for your interest in the Trista Footstool. The Textured Sky Blue is the same color for both this stool and the Bella Chair (141381).
Date published: 2017-03-16
What are the exact height dimensions?
One comment states that it is really only 10+ inches high. That makes a difference to my purchase.
Yes, the footstool at best is about 10 inches tall. Would have liked it to be a little bit taller, but still works out fine for us.
Date published: 2017-04-15
Would you describe the color of the Deep Sea leather as a Teal? Thanks!
Yes, the Deep Sea is a bright Teal.
Date published: 2016-11-12
What is the diameter of the legs.
I'm interesting in attaching casters to this. The casters are 5/16" diameter, and require me to drill a 3/8" wide by 1-5/8" deep hole. Would this work? Thanks much.
The legs of the Trista Footstool are 2" in diameter. However, we do not recommend modifying the stool as it will void the warranty.
Date published: 2015-06-10
Product:63249-Trista Footstool


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Cape Town - In the next 100 days, Police Minister Nkosinathi Nhleko will visit SAPS offices countrywide, launch a community outreach programme to encourage better relations between police and citizens, and oversee the opening of four new police stations.
Closer at hand, however, could be his ministry's involvement in steps to be announced in relation to the five-month-old platinum miners' strike, marred by killings and violence in recent weeks. This emerged during Sunday's briefing on the ANC's national executive committee meeting.
Party secretary-general Gwede Mantashe said the meeting had urged the ministers of police, justice, state security and others in that cluster to ensure the security of citizens amid strikes or protests.
"The state cannot be helpless when citizens are killed," Mantashe said, noting five workers had been killed in recent weeks. "The state can't be idle. What is today known as the Marikana debacle started with watching workers being killed… The government was nudged to deal with the matter (at the meeting)."
However, he said details would be up to the ministers. The National Union of Mineworkers (NUM) and the Association of Mineworkers and Construction Union (Amcu) have both raised concerns over strike-related violence.
Meanwhile, the August 2012 police killing of 34 Marikana miners – after the killings of 10 people, including two police officers and two mine security guards the week before – remains the subject of a commission of inquiry set to wrap up hearings at the end of next month before compiling its report and recommendations for submission to President Jacob Zuma.
Nhleko said it would be best to await the commission's findings.
'But he said it was possible the lessons would be "around operational matters and matters on leadership, which may not necessarily have to do with policing" as the SAPS became involved in what was essentially a labour dispute.
On the policing front, Nhleko said the emphasis would be on a professional, accessible service with uniform standards, accountable to South Africans in line with the National Development Plan (NDP), South Africa's vision to reduce poverty and inequality by 2030 and for an efficient developmental state.
The NDP states personal safety is a human right and a "necessary condition for human development". It outlines a demilitarised police, well-resourced and staffed by skilled professionals who render a professional service with respect for the rights of equality and justice.
"We want to focus on the NDP. We can't do that without a community outreach programme… We'll continue to look at ways and means to improve the service and increasingly professionalise the police," Nhleko said.
"We need to step up efforts to engage with residents around creating safe and secure communities."
Policing was not just about fitness or handling a gun, he said, but "how the police renders a service, how the community sees that service". Two weeks into his portfolio the minister continues to be briefed on a job which is a poisoned chalice.
As the political boss, Nhleko is in charge of policy, but implementation of policy, management and operational issues like crowd control are the SAPS's responsibilities.
The service has been marked by public turf wars in top police ranks, police brutality and killings that have hit the headlines – from the 2011 death during a community protest of Ficksburg activist Andries Tatane and the Marikana killings to the death of Daveyton taxi driver Mido Macia who was dragged behind a police van while handcuffed to it.
Despite the challenges of perception, Nhleko said today's police service had transformed itself, and continued to do so, to be a far cry from what was in place in 1994.
Police were taking action to ensure zero tolerance of wrongdoing in their ranks, he said. The number of police officers arrested for fraud and corruption had stabilised at about 20 a month, down from an average of 125 officers a month in previous years.
Political Bureau


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Crazy cat lady. she is still single, hence the love of cats. Frequently fakes injuries to get vicodon and oxy cotton. teaches orchestra and randomly screams and gets excited. when her students play exceptionally well, she EXPLODES all over them.
by Andrew Munson February 15, 2008
The Urban Dictionary Mug
One side has the word, one side has the definition. Microwave and dishwasher safe. Lotsa space for your liquids.Buy the mug


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I'm back!! !
Hubby and I ran away for new years and almost didn't come back. We spent a few days in Paris followed by a few more days traveling through Switzerland. It was a lot of fun and inspired me to travel more often.
The only thing that didn't agree with this trip was my half marathon training. I had every intention of continuing my training while away. I was supposed to run a million miles (ok not a million, but a few 5 and 6 mile runs) but not a single run was accomplished. I felt like a failure :(
How I prepared to stay fit on vacation:
- I packed 3 running outfits with all the appropriate cold/wet weather gear.
- I loaded up my IPod with inspiring new songs AND ensured it was fully charged.
What I didn't prepare for:
- The wine I would consume randomly during the day- Did I mention I loved Paris??
- The lack of Gatorade/Coconut water- Have the French/Swiss not heard of Vita coco yet? How else am I going to replenish my fluids after a 6 miler???
- How tired I would be from the change in time zone-The clock says it's 9 am but my body says it's 3 am back in NY.
- How runner un-friendly Paris is-Really, how do those skinny French women stay so skinny?
- How hard it was to fit in time to run when you have so much to see and do your first time to these countries.
- Caring for hubby when he got sick with Bronchitis and Food Poisoning- It's hard to find time to run when you have to go to "la pharmacie" and try to translate cough suppressant. Did I mention the only French I learned was on the plane over?
- How many miles I'd walk during the day sight seeing- any where from 2-8 miles in a single day.
- How exhausted and sore I'd be from skiing the Swiss Alps- I'm not very advanced so I wedge most of the way down, which totally burns your legs and butt.
|What I want to look like
|What I actually look like
I know some of these are just excuses, but every time I'd tell myself that "tomorrow is the day" a new reason not to run would soon follow. Hubby says it's fine. That any mileage on your feet is mileage, walking or running. That your body just needs time on your feet when distance training (Hubby runs marathons and other crazy long distances for fun). He's right, I was so tired and sore from all the walking each day that I felt like I'd already ran my half marathon. Not only the walking but skiing was a great workout too. Lugging all the equipment around (in super high altitude too), and skiing its self burned major calories.
So although I majorly indulged while away: eating buttery croissants, drinking full fat café au lait (coffee with milk), enjoying french cusine: steak frites, baguettes, escargot, beef bourguignon, and don't forget the swiss cusine: cheese, cheese and potatoes. I was so active during the day that I don't have to feel like a failure. Now that I'm home I can go right back to my workout/ running routine. I even found a fun French song to run to:


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Shipping Questions
How quickly will my order be shipped?
We ship on Monday through Thursday each week. If everything on your order is in stock, it will ship within 1-3 business days of the order being placed.
How long does it take to receive my shipment?
If you live in the United States, it can take 7-10 business days however if there are delays made by the USPS it may take longer. Shipments to Canada can take up to 30 days to be received due to possible custom delays.
How much is shipping and handling within the United States?
Please contact firstname.lastname@example.com for shipping information.
NOTE: US CUSTOMERS - We now offer free shipping on orders $75 or more shipping within the USA. If you have ordered a gift card this is not included. If the order goes over $75 with a gift card purchase shipping and handling will still be applied.
Our shipping and handling charges include costs for Customer Service, processing and shipping. Shipping and handling is non-refundable.
How do you ship to addresses within the United States?
We normally ship using the USPS (United States Postal Service).
Can I ship to an address outside of the United States? If so, how much will shipping cost?
At this time we are shipping to Canada only.
**Canadian Customers** If the actual shipping and handling charges are significantly higher than what you paid during checkout, we will require an additional payment to cover the costs before the order can be shipped.
What if I would prefer expedited shipping?
At this time we do not offer expedited shipping.
Do you provide tracking numbers on orders once they have shipped?
Maggie's Crochet offers tracking on most packages being shipped to addresses in the USA and Canada. If available, tracking information is sent through email when your order is shipped out.
Can I pick my item/order up in your store?
If you are local and wish to pick your order up in our shop, please contact us by phone or through email before placing your order.
How do I change the shipping address if I am not sending to myself?
To send orders to an address besides your own please follow these steps:
1. Add the items to the shopping cart and then click on your cart.
2. Click Proceed to Checkout.
3. In Checkout, Step 1 of 2 will ask you for your billing address for the order. On this same page, after entering in your billing address you have the option to check or uncheck the box labeled Ship item to the above billing address. Uncheck the box and then enter in the address you would like to have the order shipped to. Click Continue to next step.
When did my order ship?
When your order ships, you will receive notification through email to the registered email address on file.
I ordered a downloadable pattern when I meant to order a mailed copy. Can you just send me it without charging me for shipping and handling?
If you have ordered a Maggie's Crochet Brand download and would rather have it mailed, a separate order will need to be placed for the pattern with shipping and handling on it. Once that order has been entered in, we will gladly refund the cost of the original download order.
If you have ordered an Annie's Attic, Bella Crochet, Crochet Garden, Gourmet Crochet, Patty Davis Designs, Glamour4You, Sandy's Cape Cod Originals, Crafting Friends Designs, TooYarnCute, Trifles N Treasures, Hatched With Love, or Stella-Marie Publications download, we cannot mail these out. They are only available as PDF's online. All Sales Are Final On These Brands.
Please contact email@example.com with any questions.
I placed an order and used the wrong shipping address and it has shipped. What can I do?
A second order will need to be placed to have the item shipped to your new or correct address. If we receive back the original shipped order, we will be more than happy to refund the value of the item, but not the shipping cost since the item was shipped to the address confirmed at the time of checkout and was not corrected before the order was submitted and shipped out.
What happens if my order is lost in transit or if my package arrives with items missing?
We now offer tracking information on most orders. Please contact Customer Service as soon as possible if you think this has happened. Canadian customers: Please keep in mind that shipments can become delayed by customs once they have left the USA. Delivery times can vary and may take some time.
I received my package but the product is damaged. What do I need to do?
If you discover something in your order is damaged you should call us 336-992-0054, or email firstname.lastname@example.com and explain the situation. Do not send the damaged items back without having contacted us first.


text:
Changeover/Wastegate N75 Valve for A3 and B4 chassis TDIs (AHU or 1Z engines).
These have been failing with increasing frequency lately, based on our sales. Though more correctly called a changeover or wastegate valve, TDI owners commonly refer to this as the "N75 valve".
Please note this part does NOT work on the newer ALH or PD engine cars.


text:
Chocolate Amaretti Recipe
With a hint of almond, these chewy treats are similar to those sold in Italian bakeries. My husband and children are always excited when I include these in my holiday baking lineup. —Kathy Long, Whitefish Bay, Wisconsin
- 1-1/4 cups almond paste
- 3/4 cup sugar
- 2 large egg whites
- 1/2 cup confectioners' sugar
- 1/4 cup baking cocoa
- 1. In a large bowl, beat the almond paste, sugar and egg whites until combined. Combine confectioners' sugar and cocoa; gradually add to almond mixture and mix well.
- 2. Drop by tablespoonfuls 2 in. apart onto parchment paper-lined baking sheets. Bake at 350° for 17-20 minutes or until tops are cracked. Cool for 1 minute before removing from pans to wire racks. Store in an airtight container. Yield: 3 dozen.
Nutritional Facts
1 cookie: 69 calories, 3g fat (0 saturated fat), 0 cholesterol, 4mg sodium, 11g carbohydrate (9g sugars, 1g fiber), 1g protein. Diabetic Exchanges: 1 starch, 1/2 fat.
Reviews for Chocolate Amaretti
Average Rating
© 2017 RDA Enthusiast Brands, LLC


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Childhood is the purest and the most innocence-filled phase of our lives. And, when love happens during this phase, it's precious and priceless. This feeling never ceases and lingers in our memories, even after we turn adults. It's like a dream come true, when one gets to marry his/her childhood sweetheart. It's a God's gift, when one gets to lead his/her entire life with the one whom he/she have been loving since childhood days.
Not only in our lives, we get to see several such Bollywood celebrities, who have been blessed to lead their lives with their childhood sweethearts. Some of the most hot and happening Bollywood star couples are Shahrukh Khan-Gauri Chibber Khan, Hrithik Roshan-Sussanne Roshan, Ayushhmann Khurranna-Tahira, Irfan Khan-Avantika Mallik, Chitrangada Singh-Jyoti Randhawa and many others are the best examples, who have known each other since their childhood days and finally they got married.
The best thing about these Bollywood stars is that despite their rocketing career graph and the superstar status, feelings never changed. Despite achieving a lot in the tinselville, the childhood feeling never got faded away from their heart. Go through the slider to check out those Bollywood actors who married their childhood love:
Shahrukh Khan-Gauri Khan
SRK and Gauri's love story is no less than a Bollywood movie. They fell in love with each other during their teens, and finally got married.
Zayed Khan-Mallaika Parekh
Khan married his childhood sweetheart Mallaika Parekh on 20 November 2005.
Rajesh Khanna-Dimple Kapadia
Dimple married the superstar Rajesh Khanna at a very tender age, and then retired from the industry.
Hrithik Roshan-Sussanne Roshan
Both Hrithik and Sussanne have known each other, since their childhood days, but love happened gradually between the two.
Saira Banu-Dilip Kumar
Saira Banu have been a big fan of Dilip, ever since she was only 12 years old. And, one fine day her dream came true, when she married Kumar.
Chitrangda Singh-Jyoti Randhawa
Chitrangda Singh met Jyoti when she was in 8th standard. Gradually, they developed feelings for each other and finally got married.
Ayushmann And Tahira
They both have known each other for 12 years now. Once Khurranna said, "I have actually grown up with Tahira. We met after high school and were family friends. We had tuitions together and later pursued master's degrees in Mass Communication at PU together".
Aamir Khan-Reena Dutta
Aamir married his childhood sweetheart, but unfortunately the marriage did not last forever.


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Type of Document Dissertation Author Rettie, Christopher Scott URN etd-01102006-112619 Title A Performer's and Conductor's Analysis of Ingolf Dahl's Concerto for Alto Saxophone and Wind Orchestra Degree Doctor of Musical Arts (D.M.A.) Department Music Advisory Committee
Advisor Name Title Griffin M. Campbell Committee Chair Frank B. Wickes Committee Member Katherine Kemler Committee Member William Ludwig Committee Member Jane Drake Brody Dean's Representative Keywords
- Dahl
- wind orchestra
- saxophone
- concerto
- band
Date of Defense 2005-10-18 Availability unrestricted AbstractIngolf Dahl's Concerto for Alto Saxophone and Wind Orchestra was written in 1949 for the famous concert saxophonist, Sigurd Rascher and was then revised to its present state in 1953. The concerto, widely known by saxophonists and wind band conductors alike, is considered among the finest of repertoire for band as well as for saxophone. Although Dahl's concerto is one of the most frequently performed saxophone concerti, there has been surprisingly little written about it. Available published sources deal directly with the concerto, but do not address harmonic implications, the saxophone solo part, or the published wind band score.
This document seeks to address this overlooked aspect of Dahl's concerto and will provide a guide to assist performance from the point of view of the saxophone soloist as well as the conductor. The result is a new resource that will enable a greater harmonic understanding of the work for future performers.
This dissertation begins with a brief discussion of Dahl's biography and general compositional style and a section discussing the historical information about the concerto. After this brief introduction, an analysis of each movement is used to show ideas that assist a performer in better understanding the structure. Harmonic language and instrumentation are the main focuses of this section, helping the reader to form a more complete sphere of knowledge about the work. Other factors addressed include the harmonic progression of each movement culminating with each movement's harmonic role in the overall structure. As a result, a performer gains a better micro and macro understanding of the concerto. This section is divided into three chapters, each dealing with a separate movement.
Following the harmonic analysis is a section dealing with suggested performance guidelines. Among these guidelines is a discussion of aspects of performance particular to both saxophonist and conductor. The result is a better understanding of particular difficulties of instrumental parts in the ensemble, leading to a more efficient method of preparing for performance.
Filename Size Approximate Download Time (Hours:Minutes:Seconds)
28.8 Modem 56K Modem ISDN (64 Kb) ISDN (128 Kb) Higher-speed Access Rettie_dis.pdf 2.07 Mb 00:09:34 00:04:55 00:04:18 00:02:09 00:00:11


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|Home > National News > Article
|Sunday May 19, 2002
"His eyes were swollen and he had very clammy hands," she said.
Two days later she was alarmed to find a huge bruise on his hand, where he had hit the wall in frustration.
"In recent months there had been up to 18 prisoners at a time in an area with bunks for five to six. They were rotating to sleep. Their bedding consisted of cushions and short blankets, because of the risk of hanging themselves."
Mrs Wilkins began researching the issue, also the subject of a two-year campaign in the local Bendigo Advertiser. She discovered that the State Ombudsman, Dr Barry Perry, had been asked to report on the issue.
Nobody knew when it would appear.
Feeling "hog-tied", Mrs Wilkins decided that a hunger strike was her only option.
On Friday May 3, she arrived at the police station with a hastily printed poster, a sleeping bag, a groundsheet, a chair and a large bottle of water.
The following Monday, the fourth day of her strike, her son Darin was transferred to a prison at Castlemaine and then to Melbourne.
But other prisoners were still in the cells. The placard she'd had printed promised that she would only eat when the prisoners in the police cells could "breathe fresh air once a day".
So Mrs Wilkins vowed to continue her hunger strike until all prisoners were transferred from the lock-up to jails where they could see daylight, have their own bunk and be let out into an exercise yard once a day.
Hunger was only part of her difficulty. The nights were freezing, and, after the first few days, she could feel her mental responses slowing. "I needed more sugar. My doctor suggested I drink sports drinks."
But her spirits were buoyed by visits from local well-wishers and media. One school teacher even brought a class in from the school, next door, for a lesson on real-life politics.
"It was amazing to reach the younger kids with a human rights issue that was right under their noses."
On the Thursday afternoon (her seventh day of hunger strike), the Minister for Police and Corrections, Andre Haermeyer, phoned.
"He said he would send a police official to talk to me about possible movement from the cells."
The next morning, a senior police officer did come to see her, but the meeting left Mrs Wilkins in despair.
"He said all the right things but was offering nothing."
When victory suddenly came, late on Friday afternoon, it was strangely anti-climactic. Mrs Wilkins was sitting at her post outside the station when the local area commander of police arrived. He told her that all the prisoners had been moved to Castlemaine and Kyneton.
Because this was real life, not the movies, the hunger-striker had not seen the divvy vans leave the station with the prisoners.
Meanwhile, another force had been at play in the background: the long-awaited Ombudsman's report.
This explosive document hit senior police and government desks on the afternoon of Friday, May 10, just as Mrs Wilkins was about to mark the end of her first week of hunger strike. Its verdict on police cells at Bendigo, Preston, Heidelberg and Morwell was damning.
Accordingly, the Ombudsman called for the immediate removal of prisoners from these cells. It was done.
An hour after hearing that the cells were empty, Mrs Wilkins was still outside the police station.
She wasn't ready to go home. The commander had offered her a tour of the cells the next morning and she decided to wait at the station until she could have it.
"I needed closure. I needed to (go into the empty cells)."
So, with some friends for company, Mrs Wilkins decided to eat nearby, and stay up all night in the station area.
The next morning she received her tour of the cells, courtesy of the local police. At last, she could go home.
Now, just over a week since, Ann Wilkins is still glowing - and already entertaining the idea of helping others bring about change.
"I'm not a person who likes notoriety. But a lot of people are invisible as far as the authorities go and they are frustrated," she said.
"I just went there with a bottle of water and a chair. I am overwhelmed that I have, in my own way, been a form of catalyst to bring this (issue) to a head."
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Meet the makers of Melbourne's new heart
Warship stand-off
Private uni on track: CEO
Soaked, but still hip to be Squared
'If enough people take action, things can be changed.'
Games boom a financial boon
HAL holds no terrors
Summit to assess new cancer fears
From gloom to boom in just 10 years
The Dalai Lama arrives
The Dalai Lama arrives
State ALP defies court
Not just a walk in the park
Get-fit drive has city out to play
Awkward day for Kelly expert
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Retail copies of Black Ops stolen, Leak Imminent
Today in Alabama a thief took off from a local printing press with a copy of the upcoming game Call of Duty: Black Ops. The game, which is due to be released on november 9th, is currently set to be the biggest entertainment launch in history, outgrossing even Modern Warfare 2.
The alleged thief sold several of the copies of the game to associates... one of which who was a member of an underground hacking forum. The purchaser, who goes by the name of 'Ungodly Leaker' posted a thread on this forum showing the disc in his hands and making a few comments about the game. Ungodly Leaker had previously leaked Halo: Reach far ahead of its release and it is assumed intending to do the same with Black Ops.
(image removed due to copyright claim from Activision)
Treyarch's community manager, Josh Olin, attempted to join the hacking forum and negotiate with the people involved, as well as those who had dealt with the Beta Leak, but was subsequently banned from the entire forum. Regardless, he was able to get in contact with several members outside of the forums realms - one of them, a regular on the forum known as 97SIRHB, was contacted via twitter.
(image removed due to copyright claim from Activision)
For several hours, 97SIRHB's twitter account was followed by Josh Olin - who only follows less than 100 of his 80,000 followers. During this time they swapped AIM details, and talked over the phone. 97SIRHB then posted on the forum, revealling publicly that Josh was seeking information on the potential leakers and that if the game was leaked, that he would make sure the entire site was shut down.
The game, if leaked, poses to cause both Activision and Treyarch a large amount of financial harm; however a similar incident which occured last year in regards to Modern Warfare 2 was quickly quelled by private investigators and police before it could get out of hand.
As of yet it is unknown as to whether the game will be leaked in its full form in the coming days or not, but we will keep you updated as the situation progresses.


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|Gealy, David
|Estorninos, L
|Burgos, N
Submitted to: Proceedings of Southern Weed Science Society
Publication Type: Abstract Only
Publication Acceptance Date: 1/24/2006
Publication Date: 7/1/2006
Citation: Gealy, D.R., Estorninos, L.E., Burgos, N.R. 2006. Multi-year evaluation of reciprocal outcrossing rates between selected rice cultivars and red rice types at Stuttgart, Srkansas. Proceedings of Southern Weed Science Society. 59:186 Interpretive Summary:
Technical Abstract: In Arkansas various reports and observations have long indicated that hybridization between rice and red rice in farm fields can occur with either of these rice types serving as the pollen donor (male) or pollen acceptor (female). Reliable measurements of the outcrossing rates between rice and red rice have been problematic because these rates are often near the lower limits of detection, depending on the particular local environmental conditions in a given year. Experiments were conducted in isolated field plots (typically 2 or 4 m wide by 5 m long) from 2000 to 2004 to determine reciprocal outcrossing rates between pairs of diverse rice cultivars and red rice biotypes growing in adjacent drill rows. Seed from individual plots containing the rice cultivars and red rice biotypes was harvested and stored separately. In 2005, this seed was planted in long (~13 m) drill strips and the resulting seedlings were observed for the presence of phenotypic traits expected in F1 hybrids (e.g. from preliminary observations, hybrids growing in rice plots were easily distinguished by their pubescent leaves and tall heights; hybrids derived from awned blackhull red rice and growing in red rice plots were easily distinguished by their purple colored stems and pink colored awns). Plants exhibiting an expected hybrid phenotype were sampled for subsequent DNA SSR marker analysis. Preliminary results based only on phenotypic traits indicate that outcrossing rates varied greatly with Kaybonnet rice and #8 awned blackhull red rice ranged from 0.03% to 0.79% and averaged 0l.36% when red rice served as the pollen donor. However, when rice served as the pollen donor, outcrossing rates ranged from 0.03% to 0.l13% and averaged only 0.07%. By contrast outcrossing rates in plots seeded with CI-121 imidazolinone-resistant rice and StgS strawhull rice were 0.06% each year when red rice served as the p9ollen donor. Thus, outcrossing rates among year varied by more than an order of magnitude and generally were much greater when red rice served as the pollen donor. The highest outcrossing rate observed for any imidazolinone-resistant rice was 0.54% with awned #8 blackhull red rice serving as the pollen donor to CI-161 rice in 2004. DNA SSR marker analyses of all putative hybrid phenotypes are underway to confirm the presence of the expected parental alleles.


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Over on Domestic fuel there's a piece about a tallow rendering plant giving? selling? its output to a biodiesel producer. Is it any wonder that the price of tallow is rising globally? Will the refiners be paying the market rate for the tallow or are they getting it at a fixed price or free?
Tag Archives | tallow
Straight from the cow to biodisel
Tallow too pricey for australian biofuel group
Tallow, a kind of animal fat, is too pricey for an Australian biofuels group, which has decided to mothball at least one plant. The Australian Biodiesel Group (ABG) made an announcement to the Australian Stock Exchange yesterday ABG listing a series of measures it is taking to limit financial loss. These include selling off non-core […]
Bovine tallow, could that be Brazil's secret biodiesel weapon?
Over on Biodiesel BioDieselSpain.com, they have stumbled upon an excellent source of cheap biodiesl that Brazil has in abundance: Bovine tallow, could that be Brazil's secret biodiesel weapon? It looks cheap enough. The post is in Spanish, thanks to Babelfish
Tyson is developing animal fat-based renewable fuel
US meat processor, Tyson Foods, which generates around 2.3bn lbs (about 1000 tonnes) of animal fat/year as part of its food processing operations hopes to be able to turn most of it into biofuel by the end of the year, according to a report by Reuters on Planet Ark. This is not the first time […]


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Mar 18, 2012 - By Bruce Tippets, Sports EditorLander Valley High School junior Shanda Post averaged double digits in scoring and rebounding and has been named to the Class 3-A all-state girls basketball roster.
Post was No. 1 in scoring in the Class 3-A West conference at 17.5 points per game. She was No. 2 in rebounding, pulling in 11 per game.
Post also was No. 1 in the conference in assists (3.7) and steals (4.9). She was the only LVHS player to be named to the all-state squad.
Lander's Kristi Ragan earned a spot on the Class 3-A West conference team with Post.
Ragan was No. 2 scoring in the conference (15.1 points per game) and assists (3.3).
Ragan graduates in May, while Post will have one more year left at LVHS.
The LVHS pair of Tanner Simpson and Lucas Watkins claimed a spot on the Class 3-A all-state list.
"We were one of the few teams that had two players all-state," LVHS coach Terry Hopkin said.
Watkins is second in the Class 3-A West conference in rebounding (8.6). The 6-foot-7 center finished sixth in scoring (13.0).
"Lucas is a strong inside player," Hopkin said. "He had a lot of rebounds for us."
Austin Roberts, Simpson and Watkins were on the Class 3-A West conference team.
"Austin was really close to making all-state," Hopkin said.
Roberts was No. 3 in the conference in assists (3.2). He averaged 1.7 turnovers a game.
Watkins, a junior, is the only player coming back next year of the three.
"Lucas needs to focus on rebounding," Hopkin said. "His stats were pretty close to a year ago. He needs to start getting more offensive and defensive rebounds. If he does that, then I think that he will be a real force for us."
Class 3-A all-state girls basketball list
Bridigt Schumacher, Cody; Kassidy Scott, Douglas; Carlie Cecil, Douglas; Shanda Post, Lander; Kalli Federson, Rawlins; Maddie Forney, Rawlins; Lexi Erickson, Star Valley; Hailey Greenwood, Star Valley; Matty Jolovich, Torrington; Mikayla Brower, Torrington; McKenzie Hellbaum, Wheatland; Breann Jackson, Wheatland.
Girls 3-A West all-conference selections
Miranda O'Dell, Cody; Bridget Schumacher, Cody; Kiara Skinner, Cody; Molly Eastman, Jackson; Shanda Post; Kristi Ragan; Tiffani Dennis, Lyman; McKinna Salsbury, Mountain View; Patience Jones, Pinedale; Alyssa Hildebrand, Powell; Kendra Ostrom, Powell; Bailey Brog, Star Valley; Lexi Erickson, Star Valley; Christy Clinger, Star Valley; Hailey Greenwood, Star Valley.
Class 3-A all-state boys list
Aaron Fenner, Buffalo; Kalob Rodriguez, Buffalo; Brady Gulde, Cody; Tanner Simpson, Lander Valley High School; Lucas Watkins, Lander; Cisco Taylor, Lyman; Mitch Weigle, Newcastle, Chase Partridge, Powell; Kohl Battleson, Star Valley; Ridge Hillyard, Star Valley; Jason McManamen, Torrington; Ryan Madsen, Wheatland.
Boys 3-A West
all-conference selections
Brady Gulde, Cody; Brandon Hinze, Cody; Joe Caesar, Jackson; Austin Roberts; Tanner Simpson, Lander; Lucas Watkins, Lander; Nathan Jaggi, Lyman; Kyle Stokes, Lyman, Cisco Taylor, Lyman; Austin Housekeeper, Mountain View; Josh Cragoe, Powell; Marshall McArthur, Powell.
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Unfilled seats force 70 biz schools to opt for closure
Plagued with the problem of vacant seats, a total of 70 management institutes from across the country have applied for closure, Vanita Srivastava reports.delhi Updated: Feb 10, 2013 02:10 IST
Plagued with the problem of vacant seats, a total of 70 management institutes from across the country have applied for closure.
On the other hand, 80 have applied for opening new management colleges during the 2013-2014 period.
"It is a fact that the number of colleges applying for closure has increased. But at the same time, there is a fresh demand for opening of new colleges. This clearly reflects that the rate of enrollment is going up," says All India Council for Technical Education chairman SS Mantha. The online applications for opening of new colleges and closure of old colleges for 2013-2014 will end on Sunday.
"We have so far received 170 applications from educational institutions for closure. This includes 70 management institutes. Of this, there is a possibility that 50% would be closed," Mantha said.
Besides, he said that the AICTE had received 581 applications till Friday for opening of new colleges. These included 240 polytechnics, 180 undergraduate colleges and 80 management institutes.
"Even among the fresh applications, there is a probability of 40-50% being given permission for opening," Mantha said.
"Majority of the institutes which had applied for closure say they are not able to get students. Most of them are located in remote areas, possess poor infrastructure facilities, and have practically zero interaction with industries," Mantha added.
Last year, of the 138 colleges that had applied for closure, 65 were management institutes. In the same period, the council had received 669 applications for opening new colleges.
"The number of colleges applying for closure has increased by nearly four times, but still I would say it is not alarming since the number of colleges applying for opening new colleges has also increased," Mantha added.


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Prospective Students | Current Students | Alumni | Faculty + Staff
Thesis Formatting
School of Science M.S. and Ph.D. students can find answers to common questions in the Thesis Formatting and Depositing FAQ download.
For more information, please contact Debra Barker (firstname.lastname@example.com).
Manuals for Thesis Preparation
All School of Science graduate students, with the exception of those pursuing an M.S. in geology or Ph.D. in applied earth sciences, should review Purdue University guidelines for thesis preparation.
Purdue Graduate Thesis Manual
IU Thesis & Dissertation Manual


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Peach Chiffon Cups Recipe
I like to liven up individual servings with almond slices.—Heidi Doudna, Fairbanks, Alaska
- 1 can (21 ounces) peach or cherry pie filling
- 1 can (20 ounces) pineapple tidbits, drained
- 1 cup (8 ounces) vanilla yogurt
- 1 cup miniature marshmallows
- 1 carton (8 ounces) frozen whipped topping, thawed
- Fresh mint, optional
- 1. In a bowl, gently stir the pie filling, pineapple, yogurt, marshmallows and whipped topping. Spoon into serving dishes. Garnish with mint if desired. Refrigerate leftovers. Yield: 12 servings.
Nutritional Facts
3/4 cup: 146 calories, 4g fat (4g saturated fat), 2mg cholesterol, 24mg sodium, 25g carbohydrate (21g sugars, 1g fiber), 2g protein.
Reviews for Peach Chiffon Cups
Average Rating
© 2017 RDA Enthusiast Brands, LLC


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Hey there, time traveller!
This article was published 24/4/2013 (1578 days ago), so information in it may no longer be current.
In your April 22 story Students mining change, reporter Matt Preprost implies that mining companies are responsible for the deaths of five million people in the Democratic Republic of Congo. The truth is more complex than that.
The Second Congo War started in 1998, when Uganda and Rwanda invaded the eastern DRC. The roots of the conflict go past the First Congo War, which overthrew Cold War-era president Mobutu Sese Seko with Rwandan help.
Preprost completely overlooks any other causes and events in favour of only blaming mining companies. To ignore the causes of the Second Congo War is disrespectful to those who died in it and the survivors.


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What's your sign?
Customize this page by telling us what your birthday is
The sun links with Uranus, planet of changes, on your birthday so strange things will happen over the coming 12 months. But every last one of them will be a good thing too, so be positive and don't be afraid to tear down the past. It's the future that matters.
ARIES (March 21 - April 20):
You are a rebel by nature and with the sun linked to Uranus, planet of upheavals, this weekend you will do something totally outrageous. It may not do much for your reputation and it may even cost you money but you'll have fun.
TAURUS (April 21 - May 21):
It may seem as if the odds are stacked against you but the planets suggest you can easily break through any obstacles that have been placed in your path. Let everyone know you mean business. Few will dare take you on.
GEMINI (May 22 - June 21):
You get a kick out of being different and will happily upset those you consider to be too conservative in their thinking. But when you dish it out you have to be ready to take it as well. You won't get it all your own way.
CANCER (June 22 - July 23):
A craving of some sort will reach a peak and if you want peace of mind you will have to acknowledge your desires and do what you can to satisfy them. It's really no big deal – everyone needs something to make them feel good.
LEO (July 24 - Aug. 23):
You will meet some interesting people this weekend, the kind of people who look at the world from a different perspective. To you they may look a bit way out, even mad, but maybe from their point of view you look the same!
VIRGO (Aug. 24 - Sept. 23):
You may not be the most adventurous member of the zodiac but you will be tempted by what is on offer this weekend. The sun's link to Uranus, planet of surprises, will inspire you to move out of your comfort zone – and you'll enjoy it.
LIBRA (Sept. 24 - Oct. 23):
There is no point discussing what you want to do with family and friends because they are sure to try to make you change your mind. You should be confident enough to move ahead on your own initiative. Do what feels right to you.
SCORPIO (Oct. 24 - Nov. 22):
Some of the best partnerships are between people who appear to have little in common, so don't turn down an invitation this weekend just because it's from someone you find a bit weird. Chances are it will be a huge success.
SAGITTARIUS (Nov. 23 - Dec. 21):
There is no need to be cautious. There is no need to hold back. On the contrary, this is the perfect time to take chances and make changes. There may be occasions when you push your luck too far but no harm will come of it.
CAPRICORN (Dec. 22 - Jan. 20):
Usually you are careful what you say but over the next 48 hours you will go right the other way and say exactly what you think and feel. You won't lose any friends though – in fact others will find your frankness refreshing.
AQUARIUS (Jan. 21 - Feb. 19):
Upheavals of one kind or another are to be expected this weekend but they won't be too bad. They may even turn out to be good if you stay sharp and look for ways to take advantage of them. With change comes opportunity.
PISCES (Feb. 20 - Mar. 20):
A wonderful idea will occur to you this weekend and you won't be satisfied until you have done something with it. Don't worry that it does not seem "logical" because you have more than five senses. Do what your inner voice tells you.
Visit Sally at www.sallybrompton.com
For your extended forecast, call 1-900-783-8333, or 1-877-976-1414 for credit-card access. Calls cost $1.49 per minute.Report Typo/Error
Follow us on Twitter: @globeandmail


text:
New York City -- The last bureaucratic hurdles have been cleared for the construction of San Francisco's first Target location. Gavin Newsom, the mayor of San Francisco, announced Tuesday that the final permits had been issued to begin building the downtown store in January.
The 85,000-sq.-ft. Target will be located in the city's Westfield Metreon Center. The retail and entertainment complex is undergoing a major redevelopment project.
The store is scheduled to open in mid-2012.


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News360: Personalized News
by: News360 • 29.7K
All Android applications categories
by: News360 • 29.7K
Published: 2012-03-26, by Manu Galvez.
Keeping informed is becoming easier thanks to apps like News360. It provides both a mobile device and web platform to set out your own news channels. You can add categories and sources that match with your interest. There are over 10K sources, all of them English-speaking though.
Actually the amount of sources is one of its strongest point and one of its catches: it would be good if we could integrate our RSS subscription from Google Reader. Although there's a Google Reader sync option, it just looks for your interests, that's it, the topics (categories) in which your subscriptions are. It would be great if it allows both: built-in sources and personal sources integration.
And that's a pity because regarding the rest of features, this is one of the most complete and good-looking reader we've reviewed so far. It allows you to connect to your social networks (Facebook, Twitter, G+, Instapaper, Evernote, GReader) to track your interests. What's more, you can add your Read It Later account in order to add articles to your reading list easily. There are lots of settings like use GPS locations to find nearby news, enable HQ images over 3G or preload web view on WiFi only. Although it's not compulsory, it's recommendable to create a news360.com account, otherwise you won't be able to enjoy all these features.
Add, remove or edit categories and resources to your categories. Use the search bar to find an specific topic or check out your "saved" articles that you can even read offline.
In a nutshell, a complete new reader, with a stunning social integration that only needs to integrate one thing: personal sources/subscriptions on non-English speaking. Despite of that, highly recommendable.
You can review them and remove any that you don't really want to read about (and remember - you'll always be able to edit them later on). Press done when you're ready to enjoy your personalized news experience.
Tags: news360 apk , news360 , news360 1.1 apk , news360 for phone 2.2.12 , news360 llc , news360 no widget , news360 review , news360 share to non news 360 , news360 version 2.2.10 apk
by Manu , Appszoom
Mar 26, 2012
from 29.684 reviews
by Rajnish Sinha
Aug 18, 2017 | "Awesome"
Nice news app
by France Nickel
Aug 17, 2017 | "Good"
Why does it keep on crashing? So frustrating. Getting to a point of wanting to uninstall.
by Jeremy Johnston
Aug 17, 2017 | "Awesome"
Great app!
by William Manriquez
Aug 16, 2017 | "Awesome"
The best
by Raghvendra Bharti
Aug 16, 2017 | "Awesome"
Overall great app for readings news. Make one section of editorials of different newspaper also.
by Alison S
Aug 15, 2017 | "Great"
Robust topic tracking
Download News360: Personalized News
Free - V4.4.3 - 16M
Share this app


text:
Great Falls SCHEELS 5K OR Duathlon
Electric City Water Park
Sat 05/25/2013
5K, Elite, Military, Other
***EVENT DESCRIPTION HERE*** Calling all runners and walkers! Join us for our Inaugural Scheels Red, White, & Blue 5K OR Duathlon (1.5 Mile Run, 11.2 Mile Bike, 1.5 Mile Run). The races are friendly for beginners to experts. Participate as a Two Person Team or Individual for the Duathlon. Packet pick up and same day registration start at 7:00 am. Prizes will be given to fastest time in your division! First 75 participants to register receive a tee shirt and goodie bag. You may view the Bike Course here: http://www.usatf.org/routes/view.asp?rID=512942Event schedule and times ***RACE TIME, PACKET PICKUP, SPONSORS, RACE DETAILS**** Duathlon starts: 8:00am, Saturday, May 25, 2013 Race begins: 8:15am, Saturday, May 25, 2013 Race Day Registration: 7:00 am-7:50am, Saturday, May 25, 2013 Packet Pick-up: At SCHEELS Friday, May 24th from Noon-4:00PM Proceeds will go to Malmstrom Air Force Base. Sponsors include Scheels, UPS, Pepsi, & Grand Prize winner for the Duathlon will receive a pair of Hot Sands Maui Jim Sunglasses.
- Address:100 River Dr South
Great Falls, MT 59405


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TORONTO (Hollywood Reporter) - Australian director Bruce Beresford is on board to shoot the Canadian-Australian co-production "Zebras" early next year in South Africa.
The Apartheid-era true story centers on an inspirational coach who leads the country's first multiracial soccer team.
Australian playwright and screenwriter David Williamson ("The Year of Living Dangerously," "Gallipoli") wrote the script for a project that was long being developed by producers Marta and James McElroy ("The Year of Living Dangerously"). Chris Noonan ("Miss Potter," "Babe") formerly was attached to direct "Zebras."
Beresford will lead a nine-week shoot beginning in March, with seven weeks in South Africa and two in Australia. There has been no word yet on casting.
Beresford will debut his latest film, "Mao's Last Dancer," at the Toronto International Film Festival on Sunday. The same day, "Balibo," a film about five Australian journalists who witness the 1975 East Timor conflict, which Williamson co-wrote with director Robert Connolly, will screen at the festival.
Editing by Sheri Linden at Reuters


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Comedy Central has renewed the weekly topical series, The Burn With Jeff Ross for a second season. The show, executive produced by and starring the network's resident roastmaster, has received a six-episode order for a January 8 premiere. Ross executive produces The Burn with Mike Gibbons, Chris McGuire and Tagline Television's Willie Mercer and Amy Zvi. "The world is definitely a better place for having Jeff roast it on a weekly basis,"said Kent Alterman, Head of Original Programming and Production. Added Ross, "I consider it my personal mission to roast the world's big shots, bullies, and big mouths every single week. The network only had two demands: that I cut down my cursing by ten percent and my hair by eighty percent."
Comedy Central's 'The Burn With Jeff Ross' Renewed For Second Season
6 Comments
this is the perfect example of just because you have a TV show on Comedy Central, it doesn't mean that you're funny.
Big congrats to Jeff. He is one of the smartest, funniest comics out there and he has worked hard to get there. Not only brilliant, but also a good guy.
This show is dreadful. Jeff isnt funny. Comedy Central is really on the slide down with this. Jeff looks like fran lebowitz.
Best news I've heard in ages. This is such a great show, and I'm putting my name in here so people'll know I'm not linked to it in any way. I just love roast comedy; it's already such a difficult niche even when you have time to prepare material to use on people you know. But roasting strangers on the street is something few people can pull off yet almost everyone can appreciate. I loved the episode where he roasted people who parked in handicapped spaces. I especially appreciated how they left in the bit where the stoners chased him across the parking lot after he confiscated their weed. Kudos to Comedy Central for putting this show on. Jeff Ross looks like the bastard child of Honey Boo Boo's mom and Richard Simmons, but I'm starting to find that attractive – I just can't stop watching him work!
As for his pickup…
"Too Soon"
I love this show!!!!!
Fran Lebowitz


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Acne & wrinkle reducer - 2 oz
1 Recommendation
Sephora's recommendation
What it is: An advanced formula that's clinically proven to reduce acne while minimizing fine lines and wrinkles. What it is formulated to do: This multi-active treatment rapidly improves skin's appearance by alleviating existing adult acne, preventing the development of new acne, and restoring collagen to more youthful levels. With optimal collagen levels restored, skin regains a healthy resilience, fullness, and improved barrier function strength. What it is formulated WITHOUT: - Parabens - Sulfates - Synthetic Dyes - Petrochemicals - Phthalates - GMOs - Triclosan What else you need to know: This product features encapsulated salicylic acid and silver citrate to help neutralize acne-causing bacteria while penetrating deep to keep skin clean and clear. Murad's Kombucha Collagen Defenseî stimulates collagen production while significantly diminishing its breakdown. This product contains retinol and is dermatologist-developed. Research results: This product reduces the concentration of P. acnes bacteria in the skin by up to 97% in just one week of daily application. Individual results will vary.


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Much has been written about pSivida (NASDAQ:PSDV) since the FDA surprisingly entered into labeling discussions with the company about ILUVIEN, the ocular insert for diabetic macular edema. The labeling discussions came after a third failure to gain FDA approval for the same, so it came as quite a surprise. Indeed, much has been written about pSivida even before that surprise. In fact, since June, a total of 16 articles have been published on Seeking Alpha alone focusing on pSivida, including three SA PRO articles. However, as most who have a cursory knowledge of pSivida are aware, it is only getting a 20% royalty for ILUVIEN sales. The other 80% goes to Alimera (NASDAQ:ALIM), the company that sponsored its trials, by far the lion's share. For some reason, though, only one Seeking Alpha article has been published focusing on Alimera since June, and zero SA PRO articles.
If investors are going to get the full picture behind ILUVIEN and its potential return on investment, then knowledge of Alimera is critical to that end. How do the companies differ as investment vehicles as concerns ILUVIEN, and why? I will attempt to answer these questions in this article.
The Consequences of Lopsided Attention
From October 16th to the 23rd last year, pSivida fell 42% from $4.57 to $2.65 in response to the third failure to gain FDA approval for ILUVIEN. Then, on December 18th, shares rocketed back up 35% to over $4 when the surprise came. PSDV now stands at $4.43, almost exactly where it was prior to the big October 16th fall.
As for Alimera, shares fell from $3.34 to $2.18 over the same time period, about 35% in comparison to pSivida's 42% crash, and ALIM currently stands at $6.87, over 100% higher than it was on October 16th. At first glance, at least looking at the latest major ILUVIEN back and forth, it seems that the downside to ALIM is more limited than PSDV, and the upside far more pronounced. But it is not that simple.
Going back to November 11, 2011, when the two companies received the second complete response letter [CRL] rejecting ILUVIEN gives a fuller picture. On that day, ALIM fell 74%, PSDV fell only 49%. Looking at a long-term chart of the two, there is only one major noticeable anomaly.
That is, starting from the second half of 2013 until the third CRL rejecting ILUVIEN, pSivida and Alimera began to diverge, with PSDV skyrocketing and ALIM trading sideways. This is coincident with heavy pSivida coverage but near total lack of Alimera coverage mentioned at the beginning of this article. As a result, the 3rd FDA rejection of ILUVIEN had a much larger impact on pSivida on the way down than it did on Alimera. ALIM had a lot of catch-up to do with PSDV when the surprise announcement of labeling discussions for ILUVIEN was made. Therefore, that announcement had a much larger impact on ALIM on the way back up than it did on PSDV. The two stocks are now nearly neck and neck since the big 11-11-11 (at 11:00?) second CRL FDA rejection, with pSivida taking a 10% lead.
Taking the long 3-year view, past price swings have not revealed which is a better play on ILUVIEN, but they do reveal that if you see start to see divergence in two companies that should trade together (perhaps having to do with lopsided coverage), you may be able to get a discount and higher upside on the laggard.
Business Model: Alimera vs. pSivida
pSivida is a unique biotech in that it does not develop new drugs, but rather, better ways of delivering existing ones. It focuses on the treatment of chronic diseases of the back of the eye. Its business model is two-pronged: One, it develops technologies on its own and then licenses them out to other companies in exchange for funding clinical trials. Examples of this are, of course, ILUVIEN licensed to Alimera, RetiSert licensed to Bausch and Lomb, and the Latanoprost Product, which Pfizer (NYSE:PFE) has an option to license beyond Phase II. It also has a funded evaluation agreement-which could lead to a partnership-with an unnamed Big Pharma company for the development of its latest generation nanotechnological ocular suspension called Tethadur. This part of pSivida's business model keeps its cash burn relatively low ($3.5M quarterly over the last year), and it has no debt, but it puts a big lid on income in that most of the proceeds go to the companies that fund the trials. As mentioned, pSivida only gets 20% on ILUVIEN sales.
Second, it develops some treatments independently where it thinks it can do so at reduced cost. For example, it is developing Medidur for posterior uveitis, currently in Phase III trials. Medidur being the same product as ILUVIEN, but for a different disease indication, pSivida has been able to fund these trials more cheaply. If successful, pSivida will keep the proceeds for itself. All in all, pSivida having this two-pronged approach, it creates a nice balance between cost-saving and risk-taking.
As for Alimera, its business model is the flipside of the coin and is less variegated than pSivida's. Alimera's future depends almost entirely on ILUVIEN. There is information on its website about a theoretical product called NADPH oxidase inhibitors for late-stage macular degeneration, but nothing in its last 10-K about it.
On the plus side, Alimera takes home the lion's share of earnings for ILUVIEN, at 80%. As Alimera's only commercial product, FDA approval of ILUVIEN is critical to Alimera's share price. But ILUVIEN is even more important to Alimera for another reason, and that is that Alimera is licensed to develop the same product for other disease indications, each for which a separate FDA approval is needed. The other indications that Alimera has its eye on (no pun intended) are dry AMD, wet AMD, and retinal vein occlusion [RVO]. The incidence of all three of these diseases is much larger than chronic DME. The only disease for which Alimera does not have rights for ILUVIEN is uveitis, which pSivida is developing under Medidur.
Given that Alimera is almost entirely dependent on the approval and success of ILUVIEN, and that its revenues from ILUVIEN will be 4x more than pSivida's, FDA approval will probably have a larger impact on Alimera shares than pSivida. How much more, no one can say for certain, but suffice it to say that ALIM is likely a more leveraged play on ILUVIEN than pSivida.
Near-Term Catalysts: Alimera vs. pSivida
The near-term catalysts for Alimera and pSivida are the same as far as ILUVIEN is concerned. The first and foremost is FDA approval, which, according to estimates, can be expected within the next quarter or two. Others are the launch of ILUVIEN by Alimera in France scheduled for this year (page 17) and the recent recommendation for approval in Italy. Ten other applications have already been submitted for approval in other EU countries.
pSivida has an additional near-term catalyst, and that is Medidur, which, as mentioned, is ILUVIEN for uveitis. pSivida has already started the first of two planned phase 3 clinical trials enrollments for this product, and data should be available on the first phase 3 Q3 of this year.
As the company already has a treatment for Uveitis on the market called Retisert, the advantage of Medidur is that it is a more advanced microinsert technology and has less negative side effects. Medidur would be a better success than Retisert, if approved, though it would cannibalize on Retisert sales in the future, thereby leading to a gradual withdrawal of the product.
While ILUVIEN catalysts may affect ALIM on the upside more strongly, pSivida's additional near-term catalyst in Medidur may even out that leveraging effect.
The Long View: Tethadur vs. Dry AMD, Wet AMD, and RVO
This brings me to pSivida's most promising product, which Alimera is not involved in, Tethadur. Tethadur is a nano-sized honeycomb-shaped drug delivery platform, which sustainably and continually carries and releases drugs, such as Eyelea, Herceptin, and Lucentis, among others.
The BioSilicon-based protein delivery system is designed to provide sustained release of antibodies and bioerodible neuroprotective agents, along with other products in the clinical pipeline. This makes pSivida a compelling growth candidate for the next few years, assuming near-term catalysts are triggered.
Tehadur's approval is far in the future compared to its counterparts, but if approved, it would be pSivida's claim to fame.
Preclinical data is expected this summer, which could put some color on its ultimate potential. This could be the launch pad of several partnerships with leading drug manufacturers as the company strategizes for effective commercialization of the product.
The long view regarding Alimera is its commercialization of ILUVIEN for dry AMD, wet AMD, and RVO. If Alimera can reach approval for these indications, it will be a compelling long-term growth factor for the company. At this theoretical point long into the future (post-ILUVIEN approval for AMD and RVO), one could say the two companies diverge for good. Why? Because if Tethadur succeeds, it being a more advanced insert than ILUVIEN, it would theoretically replace ILUVIEN, eventually pushing Alimera's products out of the market. If Tethadur fails, Alimera would maintain its dominance.
Cash Comparison
Considering that the two companies' business models are opposite sides of the same coin, the two companies' balance sheets are remarkably similar. Alimera has had a cumulative loss of $277M since inception, pSivida $271M. They also both have similar amounts of cash on hand. Alimera has $50M, consisting of $37.5M acquired in a recent private placement and $12.6M on its latest balance sheet. With a quarterly burn rate of $12.8M that leaves about a year of cash.
pSivida has $22M, consisting of $15.2M on its balance sheet plus $7M in a recent private placement. At an average quarterly burn rate of $3.5M, that gives about a year and a half. In terms of dilution, Alimera has the ability to finance at higher rates, though at a higher cash burn level. And if and when ILUVIEN is finally US-approved, pSivida will have the cash edge, because Alimera will owe pSivida a $25M milestone payment.
Bottom line, both companies are riding heavily on ILUVIEN for now, and though approval seems highly likely given the labeling discussions, if the FDA changes its mind again, both companies' share prices could take a beating, Alimera more so than pSivida. The chances of that are highly unlikely, in my view.
All things considered, it seems that Alimera is the leveraged ILUVIEN play for short-to-mid term and has a higher risk/return on that time frame, and that pSivida is the more balanced long-term play on ILUVIEN, Medidur, the Latanoprost Product, and Tethadur. Long term, it depends on Tethadur. If Tethadur succeeds, it could be a net negative for Alimera in the future. In the meantime, both companies have significant upside pending FDA approval, and investors who believe in ILUVIEN should gain exposure to both in accordance with their risk tolerance.
Disclosure: I am long PSDV. I wrote this article myself, and it expresses my own opinions. I am not receiving compensation for it (other than from Seeking Alpha). I have no business relationship with any company whose stock is mentioned in this article.
Additional disclosure: I may initiate a long position in ALIM over the next 72 hours.


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A COUPLE who run a fish and chip shop in Ludgershall have been recognised for their support of Wiltshire Fire & Rescue Service.
Although they are only a small employer, Peter and Pauline Unwin who run Down At The Chippy allow one of their members of staff, Dean Andrews, to be an on-call firefighter and they have been supportive and understanding when he has been called away from work to serve his community.
The fire service says that, despite the inevitable impact that Mr Andrews' absence has on their business, Mr and Mrs Unwin have remained good-natured about the disruption.
And their support goes beyond freeing up a member of staff. On numerous occasions, they have provided a hot meal for firefighters on their return from an incident, making them very popular.
Mr and Mrs Unwin are also actively involved in the Ludgershall community.
At the service's annual awards ceremony, held at Potterne HQ on Tuesday, June 12, Chief Fire Officer Simon Routh- Jones presented Mr and Mrs Unwin with the Excellence Award for Employer of the Year.
This award recognises the employer who has done most to support retained firefighters in Wiltshire.
CFO Routh-Jones said: "We could not run the fire service without the support and understanding of employers such as the Unwins. In communities like Ludgershall, retained firefighters are essential to keeping people safe, but they can only provide cover if their families and employers enable them to be 'on call' and to literally drop everything when their pager goes off."
To find out more about being a retained firefighter, call 01380 731144 or visit wiltsfire.gov.uk


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Pls unprotect the Leonidas page to rewrite some of the info there which is presented in a confusing way. For example it says, Leonidas "led his people against the..." just to be mentioned later "he was wiped out along with a small band". One could think all of Sparta went to war a few of them were killed with their king. Use your reason and do something about it.--Faramir 07:42, 13 April 2007 (UTC)
- and the small band were his people.. what could be less clear than that? there's no indication in the article he displaced his entire population for the one battle.
- if anyone really wanted to edit, they simply have to register and establish themselves in the community, its not completely locked down you know. we're just blocking outsiders (who haven't established themselves in our community). -- Captain MKB 07:52, 13 April 2007 (UTC)
"Leonidas was a king of Sparta who led an army of his people against the Persians at the Battle of Thermopylae in 480 BC. Leonidas, as well as the small band of men with him, were wiped out in the battle."
There is no indication in this article that the army of his people was the small band of men with him. One could likely think the latter was his personal guard and not the army itself.--Faramir 08:03, 13 April 2007 (UTC)
- I rewrote it in the terminology used in the episode referenced. --Alan del Beccio 23:58, 13 April 2007 (UTC)


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It's Just Vanity Chicago, Illinois
We used to be a band. This used to be our bio:
Hailing from Chicago, It's Just Vanity bring a new meaning to post-rock. Formed by Louis Erazo and Kelson Fagan in New Jersey, It's Just Vanity remain true to the basement scene rock ethic they grew up with. Their sound has been described as early 90's indie emo mixed with half instrumental post-rock. ... more
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My ensuite wall needed a boost and this picture has certainly done that
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Episode Title: "Microphallus"
Writer: Matthew Carnahan
Director: Stephen Hopkins
Marty Kaan (Don Cheadle) is afraid. And he has very good reasons to be.
In the first three episodes of "House of Lies," we've seen Marty manipulate and lie to potential clients all in the name landing the contract and delivering the big bucks for his management firm, Galweather & Stearn. And if Marty destroys a few marriages (including his own) here and there and ruins a few lives… well, he's got the proverbial bags of money to sleep on in the form of his seven figure salary.
Marty is his job and there may not be a human being underneath his ruthless exterior. Despite his sexual escapades, we know that Marty's marriage to Monica Talbot (Dawn Olivieri) failed because of character deficiencies on both sides. And Marty's relationship with his son, Roscoe (Donis Leonard Jr.) is almost non-existent. Roscoe confesses to his father that he has a crush on both a boy and a girl and Marty doesn't even try to help him deal with it. A few half-hearted platitudes don't exactly make Marty father of the year.
It's only at work that Marty feels firmly in control, as he inevitably gets the cooperate raiders eating out of his hands even when he fails. The downside is that Marty operates in a way that makes him a lot of enemies; including Greg Norbert (Greg Germann) of MetroCapital. In the pilot episode, Marty inadvertently broke up Greg's marriage by bringing a stripper to a dinner date with Greg's wife; who much preferred snogging the stripper instead of her husband. A few punches later, Marty and Greg were mortal adversaries.
All of which leads us back to this week's episode, "Microphallus;" as Greg returns with the unwelcome news that MetroCapital is looking to acquire Galweather & Stearn… And Greg makes sure that Marty knows in no uncertain terms that he plans to use that power to destroy Marty's livelihood. Even Marty's boss, Harrison "Skip" Galweather (Richard Schiff) warns Marty that Greg intends to force Marty out of the company without a golden parachute while remaining bound by a non-compete clause.
The kicker is that Skip doesn't seem to care what happens to Marty one way or another. Skip notes that while Marty is insanely successful with the company, he also leaves a lot of collateral damage along the way that Skip has to clean up. More pointedly. Skip reminds Marty that they aren't friends and that he's never been invited to Marty's home before. So why should he stick his neck out for Marty?
Realizing that he's pretty screwed, Marty drags the resident devil on his shoulder, Clyde Oberholt (Ben Schwartz) out for a night of clubbing which ends with Marty stealing a high end car from the valet parking and going on a dangerous joy ride. As Clyde begs Marty to slow down, we see it. That's not joy in Marty's eyes, it's terror. For once, he's realized that he controls nothing and his carefully constructed facade could blow out at any moment.
For the case of the week, Marty and his team of Doug Guggenheim (Josh Lawson), Jeannie Van Der Hooven (Kristen Bell) and Clyde go to consult with the third largest soft drink company as it plans to implement Enterprise Resource Planning, or ERP; a major undertaking in which a company attempts to use integrated software to manage internal and external resources. It's not as simple as it sounds, or easy and inexpensive to implement. The first dilemma facing Marty is that the CEO loves the idea, but the CFO realizes it will cost the company money that it doesn't have and possibly sink the business. Problem number two is that the CFO is very cool towards Marty and problem number three is that the CFO's wife has the hots for Marty… and she doesn't bother hiding it.
Looking to bring the CFO around to his side, Marty accepts an invitation for Jeannie and himself to join the CFO and his wife for dinner at their sprawling mansion. And while the CFO gives Marty tacit approval to sleep with his insatiable wife, the CFO convinces Jeannie to give him a chance to explore his foot fetish. Oh sure, it starts out innocently enough with a foot rub. But as soon as Jeannie closes her eyes, the CFO is playing Pac-Man with the the entire top half of her foot… which Jeannie deems weird, but she doesn't tell him to stop sucking on her toes.
Upstairs, Marty learns about the CFO's "Microphallus" from his sexually frustrated wife, who gets everything that she wants out of Marty. It's amusing that both Marty and Jeannie leave the mansion feeling used and vow not to talk about what happened. But for all of their "good work," the CFO won't budge from his stance that the ERP is bad for the company. And even Marty is forced to admit that the CFO is right, even though he knows that disappointing and angering the CEO will only cost Galweather & Stearn the account that they so desperately want.
Faced with the classic no win situation, Marty opts for the outwardly honest and transparent solution of telling the CEO what will really happen if he goes forward with the ERP. And when that fails to dissuade him, Marty simply calls his friend at a company (largely implied to be Pepsi) and provides them with insider trading tips that will allow them to claim their former competitor for pennies on the dollar when their plans go down in flames. The best part is that Marty and his crew will then get the job to come back and help them cut the company to the bone… presumably for a much higher fee than they would have gotten in the first place.
At this point, we expect Marty to be morally dubious at best. However, Clyde, Doug and Jeannie have continuously appeared to be Marty's window dressing during his company presentations. In short, all of the best ideas and realizations come from Marty and everyone else is there to marvel at his ability and carry his bags. It's not the strong ensemble comedy that we thought that we'd be getting from "House of Lies." After a charming subplot last week in which Doug went down in epic flames during an encounter with dance judge, Cat Deelay; this week's minor Doug subplot dealt with him potentially sleeping with a transvestite despite his mostly strong claims to the contrary.
The entire bit between Doug and Craig over this situation wasn't funny at all; and Craig proves to be a huge a**hole when he loudly announces to the people in the plane that his colleague (whom he mentions by his full name) took a transvestite home. What else are friends for? Although, I would have enjoyed that just a little if Doug had punched Clyde out after that stunt on the airplane.
My point is that Marty is starting to come into focus as a character, but nobody else is. And no amount of foot sucking or transvestite jokes are going to change that. "House of Lies" may yet turn into a compelling comedy and I like the general direction that Marty is falling towards. But the writers of this show really need to step up their game. It's just not as entertaining as it should be.
Crave Online Rating: 7 out of 10.


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Funny DRIVE Parody Trailer - DRIVE-THRU
Here's a great parody trailer for the awesome Ryan Gosling film Drive. The comedy trailer is called Drive-Thru and it comes to us from Funny or Die. The story follows a guy who's a stunt driver by day and a fast food drive thru food orderer by night. Of course he ends up getting involved with the wrong people. Enjoy the video!
"Drive-Thru" (official movie trailer) - watch more funny videos
Joey Paur — Co-Founder / Editor of GeekTyrant.com, and if you haven't noticed I write… a lot. Movies are my passion and I live and breathe all things geek. This site is part of my life's work, it's a part of me. I love what I do, and I enjoy sharing everything I can with you when it comes to movies and geekery. In my spare time I travel to the netherworlds to battle demons. @JoeyPaur | firstname.lastname@example.com
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TV The Karate Kid, Cobra Kai, Ralph Macchio, William Zabka, Will Smith, YouTube Red Joey Paur Comment
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Makeup shade for your skin tone
Not sure which shade of foundation or blusher will match your skin tone? Click on the four models below showing before and after shots to help you.
Daniel has only made up their eyes and lips. All makeup looks are created by Daniel Sandler and all products used are Daniel Sandler makeup.


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- IBM DB2 10.1 for LUW - Information Center
is the official documentation for DB2 Linux, UNIX, and Windows 10.1. Use it to improve your experience with DB2, and get help whenever needed.
- IBM DB2 10 for z/OS - Information Center
is the official documentation for DB2 10 for z/OS.
- IBM Data Studio 3.1.1 Information Center
, the one-stop for help on Data Studio, to learn on how to do more with it.
- "Which distributed edition of DB2 10.1 is right for you?"
(developerWorks, May 2012) — Learn more about the different DB2 editions, their features and licensing models.
- Learn more about specifics of DB2 LUW through the DB2 10.1 for LUW Manuals
available in English and many other languages.
- "Migrating from DB2 Control Center to IBM Data Studio"
(developerWorks, Jan 2012) — Understand what are the differences between Data Studio and Control Center, and how to map functionalities between them.
- "DB2 Express-C 10: Even more value"
(developerWorks, Apr 2012) — Discover the new features brought to you on DB2 Express-C 10.
- Learn more about the "DB2 10 for Linux, UNIX, and Windows — New Features" to
understand what's Big Data, and to know that Warp Speed and Time Travel are now reality!
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and join the IDUG DB2 Tech Conferences.
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Risk of Life-threatening Heart Rhythm Disturbances in Siblings (SIBFIB)
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|Defibrillators, Implantable Myocardial Infarction Tachycardias, Ventricular
|Device: ICD
|Study Type:
|Study Design:
|Observational Model: Case Control
Time Perspective: Retrospective
|Official Title:
|The Sibling Concordance for Implantable Cardioverter-defibrillator Therapies in Ischemic Cardiomyopathy Study
- ICD Discharge [ Time Frame: Long-term follow up ]
|Study Start Date:
|July 2007
|Study Completion Date:
|February 2008
|Primary Completion Date:
|February 2008 (Final data collection date for primary outcome measure)
|Assigned Interventions
Sib who has received an ICD
Device: ICD
Received an ICD
Sib who has not received an ICD
Device: ICD
Have not received an ICD
Detailed Description:
Greater than 400,000 persons die suddenly each year in the US. The implantable cardioverter-defibrillator (ICD) has revolutionized the primary prevention of sudden cardiac death (SCD) following myocardial infarction (MI), however, risk stratification remains limited and rests solely on the identification of left ventricular dysfunction. The goal of this study is to determine if genetic factors influence the risk of ventricular arrhythmia remotely after myocardial infarction.
In order to determine if ventricular tachycardia or ventricular fibrillation remotely after MI is a heritable trait, we will conduct a family based case-control sibling study of patients who have received an ICD for ischemic cardiomyopathy. As a first step, we will utilize the GENECARD registry, an existing family linkage study of premature cardiovascular disease, to determine the prevalence of sibling concordance for ICD implantation following MI. Probands and siblings in the GENECARD study will be surveyed regarding their ICD history. The sibling recurrence risk ratio for ICD implantation following MI and subsequent ICD therapies will be used to estimate the sample size required to validate heritability, in a larger patient population. In the validation phase of this protocol, we will use a (1) single healthcare system database (Duke Cardiovascular Databank) and a (2) regional population-based registry, in order to determine concordance for ICD therapies. Patients who agree to participate and provide informed consent will be surveyed regarding their personal ICD history and that of their siblings. The prevalence of ICD therapies will be ascertained in the probands, siblings, and the overall cohort. Sibling concordance for ICD implantation and sibling concordance for subsequent appropriate ICD therapies will be used to determine the sibling recurrence risk ratio for appropriate ICD therapies remotely after MI.
|Ages Eligible for Study:
|18 Years and older (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
|Sampling Method:
|Non-Probability Sample
Inclusion Criteria:
- patients must be alive
- have a history of coronary artery disease / myocardial infarction
- left ventricular ejection fraction ≤ 35%
- received an implantable cardioverter- defibrillator
Exclusion Criteria:
- nonischemic cardiomyopathy
- Pre-identified hereditary arrhythmia syndrome (e.g. long QT syndrome, Brugada syndrome, etc)
- left ventricular ejection fraction >35%
- no implantable cardioverter-defibrillator
Please refer to this study by its ClinicalTrials.gov identifier: NCT00498524
|United States, North Carolina
|Duke University Medical Center, Division of Cardiology - Electrophysiology Section
|Durham, North Carolina, United States, 27710
|Principal Investigator:
|Patrick M Hranitzky, M.D.
|Duke University
|Principal Investigator:
|Jonathan P Piccini, M.D.
|Duke University
|Responsible Party:
|Jonathan P Piccini, Assistant Professor of Medicine, Duke University
|ClinicalTrials.gov Identifier:
|NCT00498524 History of Changes
|Other Study ID Numbers:
|Study First Received:
|July 9, 2007
|Last Updated:
|December 6, 2012
Keywords provided by Jonathan P Piccini, Duke University:
implantable cardioverter-defibrillator
ischemic cardiomyopathy
ventricular arrhythmias
sibling concordance
Additional relevant MeSH terms:
Myocardial Infarction
Tachycardia, Ventricular
Pathologic Processes
Myocardial Ischemia
Heart Diseases
Cardiovascular Diseases
Vascular Diseases
Arrhythmias, Cardiac
ClinicalTrials.gov processed this record on August 18, 2017