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Style: 36986669 Color Code:
Washed leather rounded toe ankle boot featuring a wrap tie with fringe detailing. Stacked heel.
FP Collection
Modern and sartorial styles, artisan crafted from fine leathers and premium materials, FP Collection shoes are coveted for their signature cutting-edge aesthetic.
these boots are my newest holy grail addition to my wardrobe and I LOVE THEM! the leather is so soft and the heel is at the perfect height! possibly my favourite pair of shoes I've EVER bought!!!!! do it girl, you won't regret buying these!
Loved it but....
I loved the shoes when I saw these online and bought the charcoal color. When the shoes arrived, looked exactly like the picture and I was happy to receive these. BUT when I wore these out, doesn't matter how you tie the straps.. The 2 flaps always escape it and you have to tie em again. I have tried wearing these out 3 times now and every time same problem. I spend the whole time pulling those flaps back up or re-tiethe shoes. Not happy because I won't be wearing these again, it's very annoying when they keep opening up and you are walking around with the straps tied to your foot but the shoe flaps (especially the back one) has pulled out!
Hello anns27, Sorry to hear about your boots. Someone will be reaching out. -Free People
Gorgeous quality, but size down
I usually take a 40 (size 9); but I've learned with free people that if a boot isn't tapered (size up), then it will be too big for me (I have narrow feet), so I size down. These boots are stunning - so comfortable to wear, totally unique, and great quality. Next up the Aqua color! :)
Strap broke
I purchased these boots a few months back and loved them but after 2 wears the trap broke entirely off. Sad because I wanted to buy in more than one coolor
Hey tinytones, We're sorry to hear about your boots! Someone from our team will be in touch. -Free People
So cute!
I ordered these in Charcoal and in Brick as I wasn't sure which colorway I liked better (I like a funky color in shoes every once in a while) and I don't think I can part with either! They are great! Worth the purchase for sure!
Love These
I love these boots! I wear a size 6 and when I got them in a 6 they fit perfectly. I've gotten so many compliments on their style and as a 5' 3" woman the heel is the perfect height: not ridiculously huge, but not just a small wedge either. After wearing them all day, my feet get sore because the inside doesn't have much cushion, but they're not particularly uncomfortable to wear. The ties can be done in several different ways. They have come undone on me a few times, but if I just knot them, they stay put. I got them in charcoal and they go with so many different things: dresses and jeans. They're great to dress things up or for casual wear. I would definitely buy them again.
I wear a sz 8 for comfort so that is what I ordered with these boots. They ran a full sz smaller...barely abe to put my foot in. Also, the tie straps on my R boot was sewn on crooked therefore unable to wear...it wound up tying in the front. I also ordered these in taupe but they are a neutral leather which was also very disappointing. Sad but returning!
Worth the purchase
I love the eclectic look they have with my black leather ankle pants.They are a bit of a pain to tie, and they buckle out if not ties properly..however, they stay in place for me and I just love the look they give to a pair of pants and a sweater. I would pruchase them again..
Looks super cute on but...
Very flattering and stylish pair of boots but the quality isn't really up to standard. The leather dye bleeds onto the cream sole which make the boots look cheap upon closer look and it is a bit of a hassle to get the ties right. However, that isn't a huge deal. I wish there was some light padding in the boot (as with most heeled shoes) to make it comfortable. I added insoles into my boot but it made it too tight for me. Overall, it's relatively comfortable just needs some light cushioning. I've kept them based on how good they look when worn but expect to be slightly disappointed by the quality. I honestly would've happily paid an extra $100 for the sole to be a darker colour, leather that doesn't bleed and with light padding.


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Title: Russell-Stoneham, Derek
URL: http://www.russell-stoneham.com/
Description: Derek Russell-Stoneham is an established wedding photographer in the UK, tailoring his service to customer requirements. Site features extensive photo galleries.
Date Submitted: 09/10/05
Listed / Last Time Edited: 03/21/17
Main Category: > Wedding Photography > Wedding Photographers in UK
Second Category (if any): R
Linkedin (if any):
Number of visitors we sent to this photo site: 839 time(s).

subset: commoncrawl


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In this new world of scale-out, clustered NoSQL databases that process thousands -- even millions -- of transactions per second, good cache management is critical for good performance. Service I/O requests from RAM whenever you can; service I/O requests from spinning disks only when you must.
Aersospike takes this principle to its logical extreme -- service all requests from RAM -- and even goes a step further: By leveraging the benefits of SSDs, Aerospike amplifies the performance and scalability of an otherwise all-RAM database. Aerospike does not completely ignore the utility of spinning disks, but "traditional" hard disks do not participate in the moment-to-moment activity of an Aerospike cluster. Instead, they serve as backup media for data protection in the event of catastrophic failure.
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Mount Pisgah Missionary Baptist Church
ph: 817-927-2463
fax: 817-927-0460
Mount Pisgah Baptish Church has been serving Fort Worth for over 100 years. Community services, developing people as a whole person, and giving an helping hand is a way of life. We strive to develop communication, social interaction, and to be a beacon of light for those who are seeking a deeper relationship with Jesus Christ.
Mount Pisgah Baptist Churh has various services and classes to cater to individuals and age groups. We also attend outside seminars, retreats and developmental classes to better service the community. For we believe the individual growth is as important as the group development.
Pastor Nehemiah Davis
Dr. Davis is a native of Centerville, Texas. His scholastic achievements include a B.A. Degree from Mary Allen College in 1955, and B.D. (1966), M. Div. and M.R.E. degrees from southwetern Baptist Theological Seminary in 1968. He received his Doctor of Divnity degree from Guadalupe Baptist Theological Seminary in 1992. His other training includes Pastoral Hospital care of Sick from All Saints Hospital, Fort Worth, Texas. His graduate studies at North Texas University. He has received extensive training on administration and leadership skills.
Dr. Davis is a member of the National Association of Christians in Social work, the Fort Worth Chamber of Commerce, the Fort Worth Metropolitan Black Chamber, and the NAACP. Dr. Davis is listed in the Diretory of Consultants of the Health and Social Welfare Services in the Dallas and Fort Worth Metropolitan Areas (1968-1970).
Dr. Davis has served in denominational work for many years. A scholar and an educator, he works with the National Baptist congress as a Lecturer in Minister's Department. He is past president of the Pastor's Conference, National Baptist Convention of Armerica; and he is President of the Minister Conference of the National Baptist Missionary Baptist of America.
Dr. Davis presently serves as Chairman of S.A. Pleasant, Jr. Institute of the Missionary Baptist General Convention of Texas and Assistant Dean of the Congress. He is Dean of the Congress of the North Texas District Association: and a teacher in the Baptist Ministers' Union of Fort Worth / Tarrant County and Vicinity. He is also a Post President of the Baptist Minister's Union of Fort Worth/Tarrant County and Vicinity.
Dr. Davis is married to the former Dorothy Nell Cole. The couple has two daughters; Carol Michelle Davis-Jackson and Nina Caron Davis, one son-in-law; Andrew H. Jackson and two grandsons; Andwar Davis Jackson and Caleb Aaron Jackson.
Dr. Davis was a 2003 inductee to the Religious Hall of Fame in Dallas, Texas, and is one of the first recipients of the coveted Dr. W. N. Daniel Service Award
Mount Pisgah Missionary Baptist Church
ph: 817-927-2463
fax: 817-927-0460


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Franciscan Spirituality Paperback
Following St Francis Today
by Brother Ramon SSF;
In Stock - Usually dispatched within 48 hours
Price and PurchaseOffer price: £14.58 Free UK Delivery Go to Basket
Franciscan Spirituality
Full Product Description
Brother Ramon, an Anglican Franciscan friar, shows us that Franciscan spirituality is as compelling and relevant today as ever. It is marked by spontaneity and emotional freedom, by openness to every human being and love for nature. It treasures both the evangelical and the catholic nature of the gospel. It is rooted in a biblical faith and in reverence for the whole of creation.
Franciscan Spirituality introduces us to the world of Francis and his first followers and shows how their excitement and wonder at Jesus alive in their midst can still be recaptured.
Franciscan Spirituality by Brother Ramon SSF was published by SPCK in May 2008 and is our 21947th best seller. The ISBN for Franciscan Spirituality is 9780281060320.
Reviews of Franciscan Spirituality
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Franciscan SpiritualityIan Gibson, via The Good Book Stall
Written by a Franciscan Friar who became a hermit, this book explores the heights and depths of the whole way of life that St Francis lived and expounded. The spirituality that was portrayed by Francis is still as relevant today and perhaps even more so with the pressures of everyday life. The book tells of the early life of the saint, the path that he trod to explore his faith and spirituality, the love that he shed and gave to everyone he came into contact with and the prayerful spirituality that is his legacy to us. For those who are seeking and want some guidance, this book could be useful, it takes the whole of Francis's life and expectations for those who wish to follow him, in depth. He leaves no stone unturned of the expectations required of those who follow Christ, the life we must live the sharing, the giving. Brother Ramon himself gave all these and now he writes of them. This book should be shared by all traditions for the value is enormous.
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|Page last updated
|24th December 2015
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|Brother Ramon SSF
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|Home > National News > Article
The newly formed homicide squad has only 40 full-time detectives to deal with 110 unsolved murders.
The squad, whose commander, Nick Kaldas, would not comment, has a nominal strength of 70 officers and staff. There are meant to be seven detectives on each of the squad's seven murder teams. But officers, who did not want to be named, told the Herald that most teams, which had up to 15 cases to investigate, were short one officer. One team had only three investigators.
Mr Abernethy also recommended that a full-time team be created within the homicide squad to review up to 200 unsolved "cold" murder cases, some of which date back to the 1960s. At present, only one officer, working part-time three days a week, has the task of locating exhibits and salvaging case files for review.
Mr Abernethy's recommendations came from hearing evidence over the past year on the murders of Leanne Beth Goodall, 20, Amanda Robinson, 14, and Robyn Hickie, 18, in the Newcastle region between 1978 and 1979 in which he found "inadequate accountability in homicide investigations".
His concern about a lack of homicide detectives comes at a time when the State Crime Command, which includes the homicide squad among its specialist investigation units, is experiencing budget restraints in the face of an expected operations budget overrun of $2million.
Detectives who spoke to the Herald but did not want to be identified said budget restraints had led several times to officers not being sent to help local police elsewhere in the state with a fresh murder inquiry.
They are also concerned that lack of resourcing and the inability to help local detectives may lead to mistakes through lack of critical analysis.
"We are talking here not just about 110 current murders that we are investigating or assisting in, but 110 families that need answers," one officer said.
"Delays can lead to people getting away."
A spokesman for the Opposition Leader, John Brogden, said Mr Abernethy's comments were "deeply disturbing".
"They reflect what the Opposition has been trying to highlight - that detectives are being starved of funds and support by this Government, in favour of high-profile, 'feel good' operations," he said.
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Great First Cruise: Navigator of the Seas Cruise Review by firstname.lastname@example.com
Overall Member Rating
Great First Cruise
Destination: Eastern Caribbean
Embarkation: Fort Lauderdale (Port Everglades)
I was able to book an eight night cruise out of Fort Lauderdale on Royal Caribbean Navigator of the Seas for just under $400 per person. I ended up booked a guarantee inside cabin, but was upgraded to an ocean view cabin on the second deck.
When we found out about our cabin location we were thrilled to get a window, but We were a bit concerned about the possible noise since our room was close to the engines and just below the main dining room. We never heard any sound from the dining room above us and the engine sound was limited to a slight constant rumble (like the sound you hear riding in an airplane). We noticed the engine sound when we stepped into the room but since it was constant we quickly were able to totally More block it out. We did notice some loud banging noises in the mornings. Some of these were when the ship docked since we were close to the water line we could hear the ship being tied to the dock. We also noticed another bang sound in the morning that we think was due to water being turned on and off in the showers in the cabins near us. I say this because my wife said she heard it loudly when I turned on our shower one morning. Overall however, these bangs were nothing to really bother us. At most they lasted for less than an hour first thing in the morning and were only a few times during that time period.
Since it was our first cruise I really don't have anything to compare our cabin with. I will say it was small. But I was expecting that. the bed was supposed to be a queen bed, but it seemed larger than that to us. In addition to our bed our cabin had one easy chair and one desk chair at the built in desk. The bath was tiny but big enough to do what you needed to do in there. The TV was old and small (they really need to upgrade to flat panel monitors). Overall out cabin was fine.
The ship was amazing. First off it's HUGE!!!!!! we often caught ourselves having to remember we were on a ship.
We loved the Promanade which is a three deck tall shopping area that runs the length of the ship. We aren't much of shoppers but it was lots of fun to stroll along and just enjoy the people watching. Plus several times during the cruise they had parades or other party type events that ran along the pramanade.
There were plenty of activities and things to do while at sea. We enjoyed the Solarium which is an adult only area with a pool, hot tubs and deck chairs. By adult only I mean that it was a place designated for adults to enjoy without having to deal with kids everywhere. The mini golf was fun too. We didn't try rock wall climbing but enjoyed watching those who did.
There were a variety of lounges and other places to relax and enjoy a drink. I personally enjoyed the cigar bar very much. This space was smallish and very quiet. It was decorated with leather chairs and distinguished art. I loved it! The attendant did a great job of serving us when we wanted but left us along to enjoy our stoggies as we wished. I didn't buy any cigars on board, preferring to purchase some at the posts we were visiting. But I did notice that the prices posted on the cigar menu were very reasonable.
The entertainment on board was fantastic. We loved the production shows and thought the concerts and special guest performers did a great job. I was wowed beyond belief by the ice show. That ice show was as impressive as any ice show I have ever seen anywhere. The ice rink was tiny which did limit a few things, but on the other hand I was able to have a seat one row off the ice with a perfect view of everything.
As for the food as we were preparing for our cruise I had read several reviews about the food on Royal Caribbean stating that it was industrial at best. So honestly going in I was a little concerned by this. What we found was that it all depended on where you ate. We found that the Windjammer Buffet was noisy, crowded and served very institutional food. We didn't particularly enjoy the Windjammer so we avoided it. But we had fantastic experiences in the main dining room. We found that breakfast and lunch in the main dining room was enjoyable with great service a pleasant atmosphere. And dinners in the main dining room were wonderful. The food was consistently good and if you didn't like what you had ordered simply ask for something else. And the service for dinner in the main dining room was the best service I have ever had anywhere in my life! We felt totally pampered by our wait staff who knew our names and remembered our drink preferences after the first meal. Additionally we really enjoyed the little bistro that is on the Pramanade. They were open 24 hours a day and served pizza, sandwiches and some of the best rum raisin cake I have ever had. Several nights we had dinner in the main dining room then would go down to the bistro on the pramanade to grab a cup of coffee and some desert to go and enjoy them from a deck chair as we watched the sea go by.
When I booked the cruise I booked at the last minute so I didn't have a choice of which dining we were to have. We were assigned late dining which means dinner was at 8:30pm. We were concerned about this at first since we normally eat at about 6. But we found that late dining was great. The advantage was that because we dined late we were not hurried when we got back from a shore excursion to get ready for dinner. We also found that on at sea days since early dining is the most popular we would have the pools and the deck chairs almost to ourselves after the early diners went to get ready for dinner.
As for the ports of call. We thought St. Maartin was okay, as I mentioned we aren't shoppers but we did enjoy the beach. St. Kitts was fantastic (I booked a tour of the island from a vendor that I read about on Trip Adviser. I saved a lot of money over choosing the cruise line tour and I found that the service was better). San Juan was lots of fun, we simply enjoyed walking around the old city. The only thing about San Juan that was a bummer is that Royal Caribbean had some sort of stink with the stink so now Royal Caribbean ships dock there really early in the day (7am) and leave mid afternoon (2pm). As a result when you get off the ship most things aren't open yet and you only have time to really enjoy one thing before its time to get back on board. Before our cruise I really didn't know what to think when I saw that we had a stop in Labadee Haiti, they call it an island but its really an peninsula on the main land. I imagined abject poverty and total destruction. What we found was that Labadee was a very well thought out resort area. It was a great place to enjoy the beach for free. You could pay for an over priced zip line ride or an equally expensive coaster type ride. But really the best thing to do was just to swim and enjoy the beach. There was also a Haitian Market area that had some highly screened locals selling stuff. As I have said we aren't shoppers so that didn't appeal to me and from what I saw the vendors were very pushy. Royal Caribbean provides a buffet BBQ on shore at Labadee which was really good. The price of this buffet is included in your ticket. The only thing disturbing about our visit to Labadee was that occasionally if you walked close to the fence you would see people begging for food on the other side of the fence (I know that's a reality of Haiti but it was hard to see).
We had a great time on our cruise. We thought the staff did a great job of taking care of us and we found the ship to be everything we had hoped it would be.
One thing I found out as I talked to people on board is that as a Cruise Critic member we could have signed up for the "Cruise Critic Crawl" where cruise critic members get a chance to see the different cabins on board and to tour the ship. Next cruise I will make sure to sign up for this. I had no idea about it until the day after it had happened. Less
Published 04/11/12
Cabin review: H Oceanview StateroomOceanview Stateroom (H) Reviews >>
Port and Shore Excursions
Read Cruise Critic's Navigator of the Seas Review >>
A bit too large for me.
Hated, loathed and despised th...
Beautiful Ship...but worse ser...
Cruise during school holidays?
Southampton to Rome and back i...
Benidorm of the Seas
Oldie But A Goodie!
First time cruisers
Would not recommend
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Most Helpful Girl
I've never had anal sex. I know someone who has though and they enjoyed it.
Thing is to me just thinking about it, I understand how the giver can get off, but I don't see how the other person can.
Well now that I think about it its probably the same way sex works.
Ugh, I don't think I'd like it though.00|00|0


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It would come like a small tightness in my tummy - not pain or discomfort but more like a questionable feeling.
Being 60 sure is a challenge. I can now understand why I always saw my parents deep in thought at this time in their lives.
My dad would chain-smoke and my mom would chain eat. They had that feeling in their bellies, too, I guess, as they started to look at their lives in a completely different way.
Dad would blow through a pack of Luckies without even thinking about it. I chuckle now as I remember January's freezing temperatures in New York, with the windows tightly sealing out the cold and locking in the smoke.
My mom would always have pasta or pizza in the refrigerator. She would make two Sicilian pizzas on Thursday or Friday for the weekend. Pizza was also good for comfort as we abided by the "no meat on Friday" rule of Catholicism.
But tea and toast were her afternoon standards. She would sit and think about things as she swallowed a little bit of comfort with each sip and bite.
Now Debbie and I are getting to the time and place where we sit for long spells dealing with the little discomforts in our bellies. Until recently we were in what we call "parent coma" - living moment to moment just trying to keep it all together. Now, as the kids are off on their own, we have time to reflect on the passages and seasons in our lives and recognize "signs and symptoms" that are not necessarily of disease but flags of change.
I have come to see the tight-tummy feeling as the "change" button being pushed - it's as if God knows you need to change so he pumps a little extra energy into your stomach to remind you that something needs rearranging in your mind and body in preparation for the next stage of your life.
I used to fight the churning of change in my tummy like my parents did, with comfort foods. It was my adult "hissy fit" to dull the ache, but it was not the medicine I needed.
Now I realize that the feeling in my stomach really was not about the horrible diet I was on but my resistance to getting out of my comfort zone and making the adjustments necessary in my life.
Embracing change and celebrating life's passages have brought positive transformation in my approach to life, not only emotionally but physically. Now I use exercise, not food, to calm and center myself as I go through life's inevitable changes.
Enjoy the journey
E-mail Bob Oro at email@example.com


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The arresting officer of the driver in the car crash that killed 13-year-old Zenani Mandela denied on Wednesday that he tried to bolster the State's case in a statement submitted five months after the accident.
Sergeant Rudolf Potsane told the Johannesburg Magistrate's Court that he did not include the reasons why he suspected the driver of the car was drunk in his arrest statement, made within three hours of the arrest of Sizwe Mankazana.
This was because these details would be covered in the operator's statement, submitted the same day.
Defence attorney Ken Oldwadge referred the court to the operator statement, signed by Potsane, and pointed out that these details were also absent from this statement.
Potsane said the details were unimportant because they were suspicions, and the Drager test confirmed Mankazana was over the legal alcohol limit. This fact – upon which the arrest was based – overrode his suspicions.
Potsane submitted another report five months later, in which he stated that Mankazana had bloodshot eyes and sluggish speech.
Oldwadge asked: "Why was it necessary to make a statement detailing your suspicions five months after, if it was never necessary?" This implied Potsane was trying to "bolster" the case against Mankazana, he claimed.
Potsane denied this.
Mankazana, 25, faces charges of culpable homicide and reckless or negligent driving after the 2010 crash which claimed the teenager's life.
Zenani, the great-granddaughter of former president Nelson Mandela, was asleep on the back seat of the car when it crashed. Her mother is Zoleka, the daughter of Zindzi Mandela.
The vehicle veered out of control on the M1 North just before a double-decker highway that bypasses the city.
Mankazana was taking Zenani home after a World Cup concert at Orlando Stadium in Soweto when the accident happened.
They were in a Mercedes-Benz CLS500.
Oldwadge asked Potsane whether he recorded the reasons that he suspected Mankazana was drunk in the regulation pocketbook which metro police officers were obliged to carry.
Potsane said he did not because he was not in charge of the investigation but was only helping the accident investigator. The pocketbook had since been misplaced.
Oldwadge asked whether Potsane had read Mankazana his rights at the time of the arrest.
Potsane said he did, but when asked whether this included the right to consult a medical professional, he said he could not recall.
Oldwadge requested an adjournment so that the court could obtain a copy of the pocketbook, as it was potentially a critical aspect.
The case resumes at 2pm. – Sapa


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River's in Washington?
View Single Post
Join Date: Oct 2008
Posts: 11
Re: River's in Washington?
Hey there,
you probably aren't going to find any gold medal flyfishing in Western Washington. A GOOD trout in the western/puget sound rivers is a fish over 12" but there are a few places where you might have a chance. Unfortunately non of them are really "close" to you.
The Cedar River out of the Seattle area has a large number of over sized trout since it opened back up, after a very long closure, just a couple of years ago. It's a drive but it could be worth it.
Even further, the North Fork of the Stillaguamish, and the Main fork as well, are awesome for Sea Run Cutthroat which can grow to fairly good sizes.
Near Everett, the Snohomish/Snoqualmie/Skykomish system also offers trout and dollies as does the Skagit, but don't expect trophies.
My personal best was a 24" 5 1/2 pounder I caught from the main stem Stilly during this time of the year (The October Caddis hatch) on a #4 tied back october caddis riffle hitched and skated. Other good flies would be egg and/or flesh flies fished below salmon redds, fry and smolt flies after the spawn or during the smolt outmigration, and minnow/shrimp imitators in the river estuaries.
The real trophy fishing takes place on the east side of the state in the Yakima River, Crab Creek, and a few other places. Potholes and the seeps lakes are worth checking out but often they are beat to death by the bait fishermen. There are some trophy lakes in eastern washington as well, like Dry falls, Lenore, etc that are flyfishing only.
Pick up a fly fishing in washington book at any flyshop and read it religiously! it has a lot of fantastic information in it!
Good luck!
View Public Profile
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text:
With lots of new gadgets being revealed at CES, Dell decided to step away from all of the gadgets (although they did unveil some new products) and announce plans for an online data migration and backup service. They're planning for this service to be available later this year in the United States, so what's it all about?
Dell is planning to enable customers to securely transfer documents, programs, drivers, settings, and other information using a broadband connection, to a secure data-storage portal. With all of their important documents and programs stored, consumers would be able to have them pre-installed by Dell during the manufacturing process.
This would be really useful when you're getting a new computer because you wouldn't have to worry about how you're going to get everything transferred over. You could just back up online and when you got your new PC, you'd be ready to go. Mr. Dell had this to say about it:


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Abstaining from alcohol during pregnancy is no picnic. Nine months without a lime rickey, then who knows how many more while nursing? It's a commitment.
Some women look at their European counterparts and cry foul. The U.K. Department of Health says one to two drinks a week for women who are pregnant or trying to become so is perfectly fine. Not surprisingly, 63 percent of British pregnant women drink.
And a study out of Denmark earlier this month indicated that pregnant women who drank moderately had kids who turned out to have better mental health than kids whose mothers abstained. But that conclusion was undermined by other factors: The abstainers also smoked more, exercised less, had less education and watched more TV than the occasional imbibers.
A new study makes an even stronger case that no alcohol during pregnancy is the best policy: A paper published by the National Bureau of Economic Research says heavy and moderate drinking – even a glass of wine now and then – "both negatively affect child academic attainment," according to a story in The Atlantic monthly.
This mirrors the National Institutes of Health guideline, which warns that "even lesser amounts can cause damage."
"The problem with drinking alcohol during your pregnancy is that there is no amount that has been proven to be safe," Dr. Jacques Moritz of St. Luke's-Roosevelt Hospital in New York said in a WebMD article.
Despite those admonitions, the Centers for Disease Control and Prevention says 1 in 8 pregnant women in the U.S. report having had at least one drink in the past month.
Older women who have high levels of estrogen have double the risk of developing dementia, according to a French study. The risk factor is 14 times higher if the patient also has diabetes, compared with women who have neither high hormone levels nor diabetes.
Study author Dr. Pierre-Yves Scarabin said the findings "are surprising, given the expected brain protective effects of estrogen-based therapy" for women after menopause.
The study was published online Wednesday in the journal Neurology.
Another report out this week, in JAMA Neurology, identified the pesticide DDT as potentially raising the risk of Alzheimer's disease. DDE, a byproduct of the metabolism of the pesticide, was found in the blood of 80 percent of Alzheimer's patients in the study, at levels 3.8 times higher than in non-Alzheimer's patients.
DDT was banned in the United States in 1972 but it still remains in the soil and waterways in some parts of the country, and is still used in other countries that export food to the U.S.
Fever serves a purpose: Higher body temperatures help kill infections. And the widespread use of fever-reducers like acetaminophen and ibuprofen might actually accelerate the spread of infectious germs from person to person, through coughing or sneezing, according to a Canadian study. The analysis at McMaster University in Ontario estimates that up to 5 percent more people get the flu each year because of the growing use of fever-suppressants.
Over-prescription of antibiotics is a big problem, since they cure a bacterial infection but not a viral one. Overuse contributes to bacteria becoming stronger and more resistant to drugs. A study at USC estimates that if physicians across the country sign and publicly display a "commitment letter" vowing to reduce inappropriate prescriptions, 2.6 million unnecessary antibiotic prescriptions would be eliminated each year, at a savings of $70.4 million.
Screening men 65 and older one time for an abdominal aortic aneurysm could reduce the diagnoses of a rupture by half, according to an influential government panel. A review by the U.S. Preventive Services Task Force says older males who smoke should be targeted because gender, age and smoking are the highest risk factors. If the wall of the abdominal aorta weakens and bulges, it could burst, a condition that is fatal about 83 percent of the time.
Magnetic resonance imaging tests can be frustratingly slow: Because up to 500 lines of data are required to make a single high-quality image, a patient can be in the MRI tube for an hour. But Yale researchers have developed a process that does its work using just one line of data, obtained with the use of curved magnetic fields. This can produce an image in 4 milliseconds.
Contact the writer: firstname.lastname@example.com


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Scattered Showers Expected Wednesday
Your Doppler 10 Forecast
This Evening: Partly cloudy and pleasant.
Tonight: Increasing clouds with a shower after 2AM. Low 64.
Tomorrow: Mostly cloudy with scattered showers. High 78.
Thursday Partly sunny with a scattered shower or two. High 80.
Special Information:
Scattered showers and possible a thunderstorm over the next couple of days. Live Doppler 10 is already showing showers back across Indiana and some of these will push into Central Ohio after midnight. Look for more shower chances tomorrow and Thursday with highs in the upper 70s and lower 80s.
Alerts : None
Inconvenient Weather: Scattered showers possible next two days. Best chance for rain will be during the afternoon… 30% chance both days.
Stats: Average high 85 average low 65. Record high 99 (1940) Record low 49(1981) Sunset 8:47PM and sunrise 6:29AM.


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Vehicle Overview from Kelley Blue Book
KBB.com 2004 Pontiac Vibe Overview
Pontiac's Hip, Hot Hatchback
The Vibe is an important car for Pontiac, representing a concerted effort by GM's performance-oriented division to regain a major part of the youth market. With the Grand Am aging fast and the much-loved Firebird no longer in existence, it falls on cars like the Vibe to hold down the fort until the next generation GTO and convertible coupes make their way to the showroom floor. That the Vibe shares much of its interior and mechanical layout with the Toyota Matrix is no secret; the two were designed and built in a joint venture between GM and Toyota. What is surprising is just how well the Vibe wears its Pontiac-inspired sheet metal. From its split-nostril grille to its racy five-spoke wheels, the Vibe screams Pontiac from every angle.
The Vibe is offered in only one body style, that being a five-door wagon. Actually the Vibe isn't really a wagon, nor is it a hatchback; it's a combination of the two that for the time being defies categorization. Pontiac says the Vibe is in its own individual segment, and that's a definition we feel is as good as any we could offer. Outside of its twin at Toyota, you really won't find anything quite like it anywhere else in the market.
There are two Vibe models to choose from: the base and GT. Each has its own engine and transmission and varying options that help differentiate one from the other. The base Vibe rides on a front-wheel drive platform and is powered by a peppy 130-horsepower 1.8-liter engine. When combined with the five-speed manual, the base Vibe proves quite a fun ride, with good off-the-line acceleration and enough power to move you to 70 mph with little fuss. After 70, the engine begins to lose steam, requiring frequent downshifts to perform passing maneuvers.
The Vibe also offers the option of four-wheel-drive. This feature greatly improves the Vibe,s already excellent traction, and may prove particularly attractive to those who have to deal with snow on a regular basis. The Vibe's four-wheel-drive system is permanently engaged, employing a viscous-coupling center differential that routes power to the rear wheels should the front begin to slip. Once traction is regained, the system reverts back to front-wheel drive. You should note that Pontiac offers the four-wheel-drive Vibe only with an automatic transmission, so though you gain a lot more grip, you lose some driving fun.
An interesting option offered on the base Vibe is a supercharger kit being produced by GM's in-house SPO division. The supercharger option can be added on by your dealer and is said to increase horsepower by nearly 35%. We have not had a chance to drive a supercharged Vibe, but we'll keep you posted once we lay our hands on one.
If you don't want to go the supercharger route, then we recommend the Vibe GT. Though the GT's engine carries the same 1.8-liter displacement as the base model, its advanced variable valve timing (VVTi) and modified heads conspire to produce a potent 173-horsepower; the base five-speed is replaced by a slick six-speed manual. Pontiac claims that the Vibe GT can run the 0-60 mph sprint in about 8 seconds and we can confirm that once the tach climbs over 5000 rpm, the Vibe GT goes like nobody's business. You will find that although the GT's engine has plenty of go, it needs to be reved high before you feel the bulk of the engine's power.
On the road, you'll find that the Vibe rides and handles like a small sports car. The steering response is direct and linear, with no trace of torque steer. The Vibe is tightly sprung, so it does not lean, roll or pitch like a tall wagon, yet somehow it returns a pleasantly smooth ride. The GT gets bigger wheels and tires and a stiffer suspension that somewhat diminish the aforementioned ride, but greatly improve the vehicle's ability to round corners at high speeds.
Inside, the Vibe is loaded with visual eye-candy, from the pod-mounted center shifter to the cool aluminum dash trim and glowing orange instrumentation. The driver's seat is height adjustable as is the steering wheel, making it easy for drivers of all shapes to find a comfortable perch. The Vibe's long rear doors make it possible to exit and enter without bumping into the doorframe and there is a good deal of real useable space behind the second row seat. One really nice feature is the flush folding passenger seat that can double as a level work place to layout your lunch or just make room for your surfboard.
The Vibe's tall roof provides excellent head room both front and rear and even six footers will find they are welcome. When not being used to haul people, the Vibe's rear seats can be folded flush to form a large flat floor; the backs even have protective plastic moldings so you won't have to worry about ruining them.


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Main Milestones
African Women?s Report 2009: Measuring Gender Inequality in Africa: Experiences and Lessons from the African Gender and Development Index
UNECA, 2009by: Economic Commission for Africa (ECA) The development of an index that best suits the needs and aspirations of the continentis timely as the region takes stock of progress in gender equality through the accountability processes of ICPD +15 and Beijing +15 reviews of 2009. The African Women?s Report (AWR) is also being launched at a time when the world observes 30 years of existence and implementation of the Convention on the Elimination of all Forms of Discrimination Against Women (CEDAW). The core objective of the New Partnership for Africa?s Development is to underscore the importance of Africa?s lead role and ownership in finding solutions to problems affecting the continent. The gathering of information and data is vital to achieving this goal. The report highlights difficulties that countries are facing with respect to the full realisation of women?s rights due, among other things, to the persistence of negative cultural and religious beliefs and attitudes towards women. High Maternal Mortality Rates as highlighted during the ICPD and Beijing +15 regional reviews of October and November 2009 and further established in the AWR is an issue of catastrophic concern. The AWR also demonstrates the different and changing dimensions of gender inequality being experienced in some countries, especially with respect to child health where there are increasing signs of male stunting, malnutrition and school drop out rates. These outcomes are not an indication of the need to reduce investments in affirmative action in favour of the girl child. They rather demonstrate lack of precise and targeted planning and implementation using tools such as disaggregated data.
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The plan for a network of electric car charge points in Canberra has received another blow after international firm Better Place officially pulled the plug on any more Australian investment.
The Israeli-based company had deals in place in the capital for a network of 16 charge points and battery-swap stations around the city.
But Fairfax reported last month that the development was on hold after Better Place said it was moving its strategic focus away from Australia, sparking fears for the jobs of the company's mostly Melbourne based Australian workforce.
In a statement issued on Wednesday, Better Place chief executive Dan Cohen said that the company would be "limiting" any more activities in Australia.
"Consultations are underway with a view to securing an orderly wind-down of its non-core activities in North America and limiting any further investment in Australia beyond its current commitments," Mr Cohen said.


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U.S Secretary of State, Condoleezza Rice left Riyadh Tuesday after an official visit to the Kingdom of Saudi Arabia, SPA said.
At Riyadh Air Base, she was seen off by Prince Saud Al-Faisal, the Foreign Minister; Prince Salman Bin Sultan Bin Abdulaziz, the Delegate-Minister at the Saudi Embassy in Washington; the U.S Ambassador to the Kingdom, James Oberwetter, and a number of officials, the agency added.
Foreign Minister Prince Saud Al-Faisal met Monday night with Rice. During the meeting, they discussed bilateral relations between Saudi Arabia and the United States and the latest developments in the Middle East especially in Palestine and Iraq.
The meeting was attended by Prince Salman Bin Sultan Bin Abdulaziz, the Delegate-Minister at the Saudi Embassy in Washington, and the U.S Ambassador to the Kingdom, as well as several officials.
[1] http://www.albawaba.com


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The War On Muffin Tops: The "Skinny Jeans Workout"
Unfastening that OMG-I-can't-breathe top button is one way to fit into your skinny jeans. But for the truly trendy, Skinny Jeans Workout classes claim to obliterate the "muffin tops" (also known as the normal, healthy "stomach") that pop over most women's zippers when we zip up our J.Crew matchstick jeans. Apparently, gyms around the country are teaching Skinny Jeans Workout classes, which remind us of the Stiletto Strength classes at Crunch Fitness Gyms that supposedly help improve your posture and make you walk more elegantly in heels. CNN spoke to some fitness instructors who said the combination ballet/Pilates/weight-lifting Skinny Jeans Workout not only tones your abdominal muscles and thighs, but gives a gal better posture so she doesn't slump over the front of her skinny jeans when she walks. [CNN]
We've got nothing against exercise, but it might make more sense to just buy a bigger, more comfortable pair of jeans instead and be able to breathe, right?


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NAG announces new numerical routines specially tuned for OpenMP at the International Supercomputing Conference (ISC12) in Hamburg
June 2012 - The NAG Library for SMP & Multicore, a de facto standard for numerical code, has been extended with an additional group of algorithms, specifically engineered for the current generation of computer systems. With new functions in important areas that include Optimization, Statistics, Matrix operations, PDE solvers and ODE solvers, the update to the NAG Library for SMP & Multicore will benefit many new and existing software developers who run code a multiple core systems.
Making full use of current computer chip architectures has required a change in thinking for the numerical community. To take advantage of the latest processor and memory configurations, NAG has re-implemented many mathematical algorithms so that they are more efficient when running on multiple cores. Additionally, new parallel routines are making their debut in the NAG Library for SMP & Multicore. These routines, such as Particle Swarm Optimization, that are chosen for their special characteristics when run on parallel architecture, can be powerful when solving important classes of problems on parallel hardware.
NAG has a longstanding reputation for providing reliable access to modern numerical analysis techniques. The NAG Library is used in fields that are as diverse as science modelling, weather forecasting, financial modelling and complex engineering design. NAG is also well-known to many leading technology organisations that base their products on NAG numerical code.
Konrad Bartkowski, of Mathematics and Education Division at the Jülich Supercomputing Centre (JSC), Forschungszentrum Jülich GmbH, in Germany, said, 'I have made extensive use of the performance optimized routines from the NAG Library, both on a PC and on two large supercomputers, as part of a research project. I integrated the copy of the NAG Library for SMP & Multicore, which was installed on one of our supercomputers, with my research code. The huge gain in performance was impressive. What is more, the flexibility of the NAG library allowed me to obtain these increases under very different system conditions such as different programming languages and different software engineering models.'
The newly engineered NAG Library routines are available now with OpenMP (Open Multi-Processing) support. 30 day trials are available for the NAG Library for SMP & Multicore.


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Dreaming of another Thomson Cruise...: Thomson Dream Cruise Review by ScottishTrish
Overall Member Rating
Dreaming of another Thomson Cruise...
Destination: Europe - Western Mediterranean
Embarkation: Other
Leaving Edinburgh our plane was delayed almost an hour due to de-icing of the wings but eventually we took off into the sunshine. Pleasant flight, not too long to wait for luggage at Palma and we were directed to the coaches pretty quickly.
Embarkation was a little confusing at times, people handing us leaflets and trying to follow the crowd but eventually we were onboard and found our cabin without a problem. Pleasantly surprised by the size, although the lack of drawers, apart from the very small one in the bedside table, was a bit annoying, and the strange tall thin cupboard with no shelves and no hanging rail puzzled us!
Our cases arrived fairly quickly brought by a smiling steward who looked after us and our cabin so expertly the rest of the week. Nothing was too much trouble. More
The beds were so comfortable and most nights I slept like a log, it was lovely to be rocked gently off to sleep. I did feel a bit of rocking and rolling a couple of nights due to the sea being a little rougher but travel sickness tablets sorted me out in no time.
We ate our meals onboard at the Lido or Sirens and could not fault a thing. The choice was plentiful and the food was delicious, so many choices, sometimes it was hard to stop!
The entertainment was fantastic, we went to a few shows and it was like being in a West End theatre. Loved the way the seating was arranged with little sofas and the two tiers was a wonderful concept. The other onboard entertainment was all first class too.
Every member of the crew was polite, friendly and so helpful. They worked tirelessy and helped to make our cruise so memorable.
We only took one organised trip to Pompeii, our guide was a lovely funny man called Marco, he made everything so interesting and was so informative. At the other ports we did our own thing, we loved Trapani, Calvi and Palamos and mostly the weather was fine, although from Wednesday it began to go downhill a little.
We were staying for a week in Majorca after the cruise and the transfer was pretty smooth, we left the cabin at 8am and sat on deck until our coach picked us up to take us to our resort. No problems there.
All in all it was a wonderful experience and certainly one we hope to repeat before too long. It will be nice to see the Dream when she's refurbished and looking spick and span! I look forward to another Dream Trip! Less
Published 10/11/12
Cabin review: OU6038
Cabin 6038 was very spacious and quiet. Beds very comfortable. Would benefit from more drawer space and the tall thin cupboard appeared pointless as nothing fitted inside it. Even a few extra shelves would have been handy.
Read Cruise Critic's Thomson Dream Review >>
Did not pay a lot, did not get...
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Lindsay Lohan has been released from house arrest on Wednesday. The Mean Girls star spent 35 days in home confinement for violating her 2007 DUI probation.
The actress, who was fitted with an electronic ankle bracelet to track her movements and ensure that she does not leave her house, was removed yesterday. Later, LiLo said that she is excited to start her community service and she wants to focus on her work.
"Lohan is very focused on resuming her community service, which is being performed at a downtown Los Angeles women's shelter and will also require her to work at the county's morgue." The CTV News quoted Lohan's spokesperson as saying.
Actress Lindsay Lohan was sentenced to 120 days in jail and 480 hours of community service for violating her 2007 DUI probation and complete 480 hours of community service for jewellery theft. But she was allowed to serve 35-day house arrest to reduce the prison population and other expenses.


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Genome Institute of Singapore
Scores Double Headway on Non-Hodgkin Lymphoma (NHL) With the Discovery of Novel DNA Variants That Influence the Risk of Blood Cancer
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June 27, 2013 -- Scientists at the Genome Institute of Singapore (GIS) recently led in two studies that revealed important genetic insights into the development of non-Hodgkin lymphoma (NHL). NHLs are some of the most common blood cancers and include any kind of lymphoma except Hodgkin's lymphomas.
A. Study 1: discovered novel inheritable gene variant that increases risk of blood cancer in Asians In the first study, reported in the prestigious scientific journal Nature Genetics, the scientists discovered an inheritable gene variant which increases the risk of non-Hodgkin lymphoma (NHL) in Asians.
In order to identify heritable risk factors influencing susceptibility to NHL, Dr Liu Jianjun, Deputy Director of Research Programmes and Senior Group Leader of Human Genetics at the GIS, led the first Asian genome-wide genetic variation analysis in Singaporean Chinese lymphoma samples. The team then validated the top findings from this analysis with three additional sets of samples from China (comprising two sets from Guangzhou and one from Beijing). In total, 1,428 NHL patients and 6,930 controls of Chinese origin were investigated in this study.
The team identified the DNA variation located in between two genes –B-cell lymphoma protein 6 (BCL6) and lipoma preferred partner (LPP) – that confers a 50 percent increased risk of NHL in individuals that carry this DNA variant as compared to those that do not. This DNA variant is thought to promote the development of NHL by influencing the expression levels of the neighbouring genes.
This study also involved the research teams from the National University Health System/National University of Singapore, National Cancer Centre, Singapore General Hospital, and Tan Tock Seng Hospital in Singapore, and from the Sun Yat-sen University Cancer Center, Guangzhou, China and Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.
B. Study 2: pinpointed culprit for high risk of follicular lymphoma
In a second related study reported in another prestigious scientific journal, American Journal of Human Genetics, GIS scientists made an in-depth investigation on the association of the human leukocyte antigen (HLA) region with follicular lymphoma (FL), a common sub-type of NHL. Previous genetic studies by the GIS scientists as well as others around the world had discovered that multiple genetic variants within the HLA region are independently associated with FL risk.
Scientists have now been able to identify a single amino acid variation encoded by the immune gene HLA-DRB1 as the culprit for these associations.
Every individual inherits and carries any two out of six amino acids of this variation. The particular two amino acids that a person carries will determine if that person has a high, moderate or low risk of contracting FL. The team discovered that individuals carrying two high-risk amino acids had a 4.2 fold higher risk than those with two low-risk amino acids.
These two studies provide novel genetic insights into the development of NHL, and pave the way for further biological investigation that can help to develop more targeted and accurate therapeutic medication.
Dr Liu said, "The novel discovery that the inheritable genetic variation of BCL6-LPP can influence the risk of developing NHL is truly an exciting one. Previous studies have been largely carried out in western populations. The success of our study has demonstrated that the investigation of Asian populations can lead to novel findings. We are now planning further Asian studies to discover additional novel risk variants for NHL by investigating larger numbers of clinical samples"
GIS' Executive Director Prof Ng Huck Hui added, "Dr Liu and his team have successfully adopted genome-wide association studies to provide crucial biological insights to many diseases such as spine disease (ankylosing spondylitis) and kidney disease (Immunoglobulin A Nephropathy). These latest discoveries are testament to their great work and underscore the importance of collaboration with academic and clinical entities."
Dr. Stephen J. Chanock, M.D., Chief at the Division of Cancer Epidemiology & Genetics, Laboratory of Translational Genomics, National Cancer Institute said, "JJ Liu and colleagues have conducted a set of informative studies in primarily Asian populations that provide new insights into the underlying genetic susceptibility to two of the major subtypes of non-Hodgkins lymphoma (NHL). Investigation of the HLA region, known to be linked to NHL risk, has revealed a series of important observations on the actual HLA genes, providing a foundation for the next generation of mechanistic studies. In addition, they have identified genetic markers in a region with a plausible candidate gene, BCL6 – the target of extensive research in NHL."
Research publication:
The research findings described in the press release were published in the advanced online issues of two journals: A. Nature Genetics under the title "Genome-wide association study of B-cell non-Hodgkin's lymphoma identifies 3q27 as a susceptibility locus in the Chinese population" on 9th June 2013, and
B. American Journal of Human Genetics under the title "Coding Variants at the Hexa-allelic Amino Acid 13 of HLA-DRB1 Explain Independent SNP Associations with Follicular Lymphoma Risk" on 20th June 2013.
Authors for Nature Genetics paper:
Dennis E.K. Tan1,22, Jia Nee Foo1,22, Jin-Xin Bei1,2,22, Jiang Chang3,4,22, Roujun Peng2, Xiaohui Zheng2, Lixuan Wei3,4, Ying Huang3,4, Wei Yen Lim5, Juan Li6, Qian Cui2, Soo Hong Chew7, Richard P. Ebstein8, Ponnudurai Kuperan 9, Soon Thye Lim10, Miriam Tao10, Suat Hoon Tan11, Alvin Wong12, Gee Chuan Wong13, Soo Yong Tan14, Siok Bian Ng15, Yi-Xin Zeng2,16, Chiea Chuen Khor1,5,17,18,19, Dongxin Lin3,4,23, Adeline L.H. Seow5,23, Wei-Hua Jia2,23, Jianjun Liu20,21,1,5,23
1. Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore
2. State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou, China
3. State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China
4. Department of Etiology and Carcinogenesis, Cancer Institute and Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China
5. Saw Swee Hock School of Public Health, National University Health System, National University of Singapore, Singapore
6. Department of Hematology, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
7. Department of Economics, National University of Singapore, Singapore
8. Department of Psychology, National University of Singapore, Singapore
9. Division of Haematology and Laboratory Pathology, Tan Tock Seng Hospital, Singapore
10. Division of Medical Oncology, National Cancer Centre, Singapore
11. Department of Dermatology, National Skin Centre, Singapore
12. Department of Haematology-Oncology, National University Health System, National University of Singapore, Singapore
13. Department of Haematology, Singapore General Hospital, Singapore
14. Department of Pathology, Singapore General Hospital, Singapore
15. Department of Pathology, National University Health System, National University of Singapore, Singapore
16. Peking Union Medical College, Chinese Academy of Medical Science, Beijing, China
17. Singapore Eye Research Institute
18. Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
19. Department of Pediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
20. School of Biological Sciences, Anhui Medical University, Hefei, Anhui, China
21. Institute of Dermatology and Department of Dermatology, No.1 Hospital, Anhui Medical University, Hefei, Anhui, China
22. These authors contributed equally to this work.
23. These authors jointly directed this work.
Authors for American Journal of Human Genetics paper:
Jia Nee Foo1,17, Karin E. Smedby2,17, Nicholas K. Akers3, Mattias Berglund4, Ishak D. Irwan1, Xiaoming Jia5,6, Yi Li1, Lucia Conde7, Hatef Darabi8, Paige M. Bracci9, Mads Melbye10, Hans-Olov Adami8,11, Bengt Glimelius4, Chiea Chuen Khor1,12,13,14, Henrik Hjalgrim10, Leonid Padyukov15, Keith Humphreys8, Gunilla Enblad4, Christine F. Skibola7,18, Paul I.W. de Bakker5,6,16,18, Jianjun Liu1,14,18
1. Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore 138672, Singapore
2. Department of Medicine, Clinical Epidemiology Unit, Karolinska Institutet, Stockholm SE-171 77, Sweden
3. School of Public Health, Division of Environmental Health Sciences, University of California-Berkeley, Berkeley, CA 94720, USA
4. Department of Radiology, Oncology and Radiation Science, Uppsala University, Uppsala SE-751 85, Sweden
5. Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA
6. Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA
7. School of Public Health, Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
8. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm SE-171 77, Sweden
9. University of California, San Francisco, Department of Epidemiology and Biostatistics, San Francisco , CA 94107, USA
10. Department of Epidemiology Research, Statens Serum Institut, Copenhagen DK-2300, Denmark
11. Department. of Epidemiology, Harvard University, Boston, MA 02115, USA
12. Singapore Eye Research Institute, Singapore 168751, Singapore
13. Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119074, Singapore
14. Saw Swee Hock School of Public Health, National University Health Systems, National University of Singapore, Singapore 117597, Singapore
15. Rheumatology Unit, Department of Medicine, Karolinska Institutet and Karolinska University Hospital Solna, Stockholm SE-171 76, Sweden
16. Department of Medical Genetics and of Epidemiology, University Medical Center Utrecht, 3584 CX Utrecht, the Netherlands
17. These authors contributed equally to this work
18. These authors jointly directed this work
Correspondence should be addressed to:
Jianjun Liu, firstname.lastname@example.com, tel (65)6808-8088
Winnie Lim
Genome Institute of Singapore
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About the Genome Institute of Singapore (GIS)
The Genome Institute of Singapore (GIS) is an institute of the Agency for Science, Technology and Research (A*STAR). It has a global vision that seeks to use genomic sciences to improve public health and public prosperity. Established in 2001 as a centre for genomic discovery, the GIS will pursue the integration of technology, genetics and biology towards the goal of individualized medicine.
The key research areas at the GIS include Systems Biology, Stem Cell & Developmental Biology, Cancer Biology & Pharmacology, Human Genetics, Infectious Diseases, Genomic Technologies, and Computational & Mathematical Biology. The genomics infrastructure at the GIS is utilized to train new scientific talent, to function as a bridge for academic and industrial research, and to explore scientific questions of high impact.
About the Agency for Science, Technology and Research (A*STAR)
The Agency for Science, Technology and Research (A*STAR) is Singapore's lead public sector agency that fosters world-class scientific research and talent to drive economic growth and transform Singapore into a vibrant knowledge-based and innovation driven economy.
In line with its mission-oriented mandate, A*STAR spearheads research and development in fields that are essential to growing Singapore's manufacturing sector and catalysing new growth industries. A*STAR supports these economic clusters by providing intellectual, human and industrial capital to its partners in industry.
A*STAR oversees 20 biomedical sciences and physical sciences and engineering research entities, located in Biopolis and Fusionopolis as well as their vicinity. These two R&D hubs house a bustling and diverse community of local and international research scientists and engineers from A*STAR's research entities as well as a growing number of corporate laboratories.
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Each year around the league, unsuspecting superstars are born and uncommon names become household regularities. It's as consistent as death and taxes, and while the odds are long considering the vast number of players who attend training camp, the opportunity is there for the taking. The New York Giants, of course, know this all too well after discovering wide receiver Victor Cruz, who went from camp fodder to one of the most well-recognized athlete's in the world.
While replicating the success of Cruz is much more rare than finding a solid player amongst a 90-man roster, the possibility always remains that there's a needle in the haystack. And although we won't go as far as to say there's another Cruz headed to training camp, we will take a look at five potential sleepers who not only stand a chance at making the 53-man roster, but have what it takes to make a legitimate impact on the field in 2014.
5) Markus Kuhn, Defensive Tackle
When Linval Joseph left and signed with the Minnesota Vikings early on in free agency, the common belief was that 2013 second-round pick, Johnathan Hankins, would immediately step in and take over at defensive tackle for the New York Giants. And although he had an impressive Spring, it's no sure bet to pencil him in alongside Cullen Jenkins…at least not yet.
Despite Hankins flashing more often than not, he was met step-for-step this past Spring by a forgotten man: 2012 seventh-round pick Markus Kuhn.
"He had an outstanding offseason, really outstanding practices. He and Hankins, they'll definitely get more reps in training camp than Mike P and Cullen if everything goes as planned," defensive line coach Robert Nunn said. "He showed up every day. When we go out there and go in team situations Markus was, there wasn't a day that went by that we didn't call his name out in a positive manner."
Kuhn, who tore his ACL in Week 10 of his rookie season and missed much of the 2013 season recovering, arrived for offseason workouts in tremendous shape and with a warrior's mentality. And his relentless work ethic, which has been soundly praised by Tom Coughlin since the defensive tackle arrived as a rookie, has helped draw the attention of the decision-makers.
While Kuhn starting over Hankins may be a bit of a reach, there's a legitimate chance he earns quite a bit of playing time as the No. 3 defensive tackle in what has potential to be a very strong rotation.
4) Dan Fox, Linebacker
The injury to linebacker Jon Beason — one that will likely sideline him until at least Week 1 of the regular season — opened the door to a number of other players. Among them is undrafted rookie free agent Dan Fox out of Notre Dame.
Of all five sleepers we have listed, Fox would appear to have the longest odds of not only making an impact in 2014, but even making the team. However, after signing with the Giants, he arrived to team facilities in great shape and immediately dove into the playbook, while also learning as much as he could from the veterans. In fact, he's clung to them in an effort to learn all three linebacker positions, which has shown on the field as coaches have mixed him in at each position.
"This is kind of a new position a little bit, I've been doing a lot of Sam and Will in camp but have played some Mike. I've done a little bit of everything and it's fun learning all the positions. I'm just trying to make the team," Fox said.
Although he faces stiff competition from other players like Terrell Manning, whom we also considered for this list, Fox has already opened eyes and appears poised for a very busy training camp/preseason that could ultimately earn him a spot on the 53-man roster — or at least the practice squad.
3) Mario Manningham, Wide Receiver
We know what you're thinking… How can Mario Manning, an NFL veteran and Super Bowl champion, possibly be considered a sleeper? It's a question we debated and pondered for several days before deciding to add his name to this list.
The reasoning behind it is multi-tiered and has less to do with his NFL experience, and much more to do with the reality that after returning to the Giants and missing the offseason workout program, he's become somewhat of a forgotten man. And because it's now an "out of sight, out of mind" sort of scenario, that very much makes him a potential sleeper.
General Manager Jerry Reese did not bring Manningham back to be a feel good story — he brought Manningham back to add a weapon to Big Blue's new-look offense and to contribute here in 2014. And with Manningham comes familiarity with both the Giants franchise and at least some level of continuity with quarterback Eli Manning. Not only that, but the 2014 version of Mario Manningham is drastically different from a maturity standpoint than the Mario Manningham we last saw in 2011.
During his time with the San Francisco 49ers, Manningham faced the first true adversity of his professional career after tearing his ACL in 2012. He then returned to the field entirely too soon, eventually suffering a setback in 2013 that has left him shelved ever since. And although he is now nearing a complete return to health, it was those experiences that have helped re-shape him both as a person and a player.
"It was frustrating, but it was a learning experience also," Manningham said. "When I got back I couldn't do what I wanted to, I knew I needed a little bit more time. It's coming along and I just have to work on getting stronger and getting my strength back and trusting it more. I'm doing good; it's getting stronger.
"If you're an athlete, you have a chip on your shoulder already, so you're like, 'I'm coming back strong this year.' I do believe it. I had a couple people who tore their ACL a couple times who said, 'Man, you're not going to get it back that following year, you're going to get it back the year after that.' I'm just trying to do what I can do to make a strong impact and win games."
What you have now is a very hungry, very determined and much more mature wide receiver who's looking to return his football career to a satisfactory level of success.
2) Brandon Mosley, Offensive Line
After being drafted in the fourth-round of the 2012 NFL Draft, expectations were relatively high for offensive lineman Brandon Mosley. Unfortunately, his rookie campaign was derailed in short order due to an ankle injury and he wouldn't return until 2013. Accordingly, the Giants' coaching staff approached last season as if it were a rookie year for Mosley despite almost immediately taking first-team snaps in place of Kevin Boothe who was replacing the injured David Baas at center.
Although he ended up playing only 60 snaps over five games, Mosley showed significant improvement. He was also one of the few offensive linemen who finished the season without allowing a single sack or hit. Now in his third season, and with Big Blue desperately needing someone to step up along the offensive line, Mosley appears to be seizing his opportunity.
"I see improvement on a daily basis, I really do," offensive line coach Pat Flaherty said. "He's, as we sometimes forget, Brandon is really in his second year. His first year he was on IR. He was with us in training camp and then he had his foot operated on and he was put on injury reserve so he missed a year of football activity. Last year was really his first year and he was progressing very well and then when he had the opportunity to really take the bull by the horn again Detroit he went against a good football player and was rally battling pretty good and then he broke his hand and it started all over for him again."
Despite his limited number of snaps in 2013, Pro Football Focus gave him an above-average run blocking grade. Now just think about what he'll be able to do with health and a full offseason under his belt.
1) Charles James, Cornerback
Also a sleeper in 2013, James managed to earn himself a spot on the Giants' practice squad before eventually being signed to the 53-man roster and playing in 12 games — primarily as a special teams gunner.
Now with the team having signed Dominique Rodgers-Cromartie, Walter Thurmond III and Zack Bowman, James once against finds himself in a battle to earn a roster spot. And no longer eligible for the practice squad, it's active roster or bust for the second-year cornerback out of Charleston Southern.
But James is no stranger to long odds and certainly doesn't doubt his own ability. Throughout his life he's routinely faced down his doubters and proven them wrong. And knowing he'd have to prove himself once again in 2014, James spent the majority of his offseason working out with Steve Weatherford, preparing for the exact moment that sits ahead of him come training camp.
"I'm ready to go out and show what kind of player I am," James said. "As a rookie, you try to grasp. I want to come into my own, be a better person. This offseason is big. I'll hit training even harder, summer harder, training camp big, and ready to come into my own and show I can be a player in this league for many years."
Although there would appear to be no room on the cornerback depth chart pending the health of Trumaine McBride — especially given the big money the Giants spent on their free agent additions — James impressed during the offseason workout program, flashed in practice and drew praise from several of his teammates and coaches. It would be uncharacteristic of the never-say-die James for that not to carry over into training camp — so, if nothing else, expect James to force the Giants into a very difficult decision. But do not be surprised if he once again overcomes the odds and lands himself a spot on the 53-man roster.
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Tags: Brandon Mosley, Charles James, Dan Fox, Eli Manning, Football, Jerry Reese, Mario Manningham, Markus Kuhn, New York, New York Giants, NFL


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Federal trade minister skirts coal export issue
International Trade Minister Ed Fast won't say if he supports the controversial export of U.S. coal through Port Metro Vancouver, which is proposed to greatly increase if a new terminal is approved at Fraser Surrey Docks.
The federal minister was asked that question by Black Press following a speech Thursday before the Surrey Board of Trade.
Port Metro Vancouver maintains its role is strictly to act as a conduit for all cargo and that any policy decisions to exclude certain commodities would be up to the federal cabinet.
"I'm not going to prejudge the outcome of the application to develop a coal terminal on the Fraser River," Fast responded.
He said it's always his goal to expedite trade in and out of Canada, but environmental standards must be met and regulatory processes must be followed.
"I'm confident that the process is fair and I'm prepared to wait for that process to be completed before commenting further."
Port Metro Vancouver could decide at any time on the Fraser Surrey Docks direct coal transfer facility.
It would take at least four million tonnes per year of U.S. coal by train through White Rock and Surrey and send it by barge down the Fraser River to Texada Island for reloading to ocean-going ships.
Climate change activists think U.S. coal might stay in the ground and not be burnt overseas if new coal terminals aren't built in Metro Vancouver or along the U.S. west coast.
Fast was less reticent when asked if he's concerned that public resistance to port expansion and pipelines in B.C. poses an impediment to Canadian trade with the Pacific region.
He said it's "absolutely imperative" to get Canadian resources to new buyers so they are no longer captive to U.S. markets.
"We leave tens of billions of dollars on the table every year because we don't have that critical infrastructure in place," Fast said, adding regulatory reviews must be completed before any projects are judged.
Fast's speech to the business audience highlighted growing trade opportunities with Europe as well as South Korea as a result of lowered tariffs.
He predicted B.C. growers of blueberries and cherries will be among the beneficiaries of expanded markets.
Another focus is India, where Fast will lead a trade mission in October.
Fast also said B.C. could be in line for more federal infrastructure grants to support port and trade-related gateway infrastructure, on top of the billions previously spent on projects like the South Fraser Perimeter Road and various rail overpasses to ease the flow of goods.
"There's another $4 billion we will be investing to make sure that the geographic advantage we have already in the Asia Pacific is preserved."


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Deutsche Bank has reaffirmed its "buy" recommendation on
Locally, CMC is the third-largest scrap recycler behind Sims and OneSteel and the third-largest distributer behind OneSteel and BlueScope Steel. Deutsche says that the Icahn bid for CMC creates upside for Sim.
The broker has kept its 2012 earnings per share forecast at $1.12, slightly below the consensus figure of $1.15, while its 2013 forecast remains at $1.54, slightly ahead of the $1.53 consensus. Deutsche's 12-month price target stays at $19.30.
The Australian Financial Review


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Durham bullish on craft beer, local tastes
Posted February 25, 2013
Updated February 26, 2013
Durham, N.C. — The Durham Performing Arts Center turned into a foodie delight Sunday afternoon for the first Bull City Food & Beer Experience. Sponsors Sam's Quik Shop and Tyler's Taproom brought together their favorite craft beers and local cuisine to share with guests, who roamed the DPAC halls, quaffing brews from the Triangle and beyond while sampling small tastes custom-created as accompaniments. Bull City Food & Beer Experience
In addition to food and drink, visitors were treated to live music from Chapel Hill folk trio Mipso and keynote talks from brewers representing New Belgium, Oskar Blues and Sierra Nevada breweries.
Sierra CEO Ken Grossman drew a crowd with the plans for brewery's first east coast location, under construction in Henderson County.
Triangle-area breweries like Raleigh's Big Boss and Fuquay-Varina's Aviator sampled side-by-side with national names like Sierra and Abita.
A select number of brewers paired their pours with creative culinary choices prepared on the spot.
At the Olde Hickory table, a butcher from Mateo Tapas carved fresh prosciutto which his colleagues used to top garlic-rubbed buschetta.
Vin Rouge French Bistro served up a twist on bratwurst paired with Foothills brews from Winston-Salem.
Watts Grocery spread foie gras and pickled butternut squash on toast points to serve with Haw River Farmhouse Ales.
G2B Gastropub offered tarts that ranged from meaty to chocolate ganache.
But possibly the most off-the-wall yet perfect pairing was the Welsh Rarebit made with Mother Earth Silent Night Stout served by Six Plates Wine Bar. The classic beer-cheese sauce topped a crostini with a bit of bratwurst and was accompanied by a handful of popcorn dashed with either duck fact or chorizo.