text:
|Publication number
|Publication type
|Application number
|Publication date
|Jul 4, 1989
|Filing date
|Oct 23, 1987
|Priority date
|Jul 26, 1985
|Fee status
|Also published as
|Publication number
|Joel R. Mitchen
|Original Assignee
|Mitchen Joel R
|Export Citation
|BiBTeX, EndNote, RefMan
|Patent Citations (22), Referenced by (39), Classifications (18), Legal Events (7)
|External Links: USPTO, USPTO Assignment, Espacenet
This is a continutation-in-part of my prior applications Ser. Nos. 574,901, filed Jan. 30, 1984, now abandoned, and 759,618, filed July 26, 1985, now abandoned.
The present application relates to the collection of tissue fluids. Most particularly, it relates to a method and apparatus for the non-invasive transcutaneous collection of such components from a human or animal.
In the past, researchers and clinicians requiring a sample of the blood of an animal usually have obtained that sample by either piercing or nicking the skin of the animal and then collecting the sample from a vein or artery. At times the sample was collected with the assistance of a vacuum.
It would obviously be advantageous to have a method of collecting fluid related to blood and blood components which does not reuqire the piercing or nicking of the skin. The nonblood intestitial and cell fluids of the skin relate to blood as determined by punch biopsies analyzed and compared by many workers.
The general object of the present invention are to disclose a noninvasive method for the collection of tissue fluid from a man or an animal and to disclose a device for conveniently practicing the method, not possible until now.
Briefly stated, the present invention comprises pretreating the external surface of an area of the skin (epidermis, epithelial cells) of a human or animal to clean off dead cells and increase the permeability of the skin to tissue fluids, forming a liquid coating and wetting the skin, forming a superficial contusion on that area of the skin without nicking or piercing the skin, and then, with the aid of the liquid coating and vacuum, collecting skin fluid containing the desired components from the area of the contusion. The skin fluid collected is suitable for diagnostic purposes.
The preferred device of the present invention comprises a probe having a cup-shaped member for holding a coating liquid and forming a seal with the skin at one end and means for receiving a sealed vacuum tube at the other end. The probe includes a deflector positioned within and partially filling the cup-shaped member and means for opening the seal of the vacuum tube when the cup-shaped member is sealed against the skin so that the deflector and vacuum cooperate to form a contusion and the vacuum and a coating of liquid on the skin cooperate to transfer skin fluid fluid into the vacuum tube.
In the drawings;
FIG. 1 is a perspective view of a preferred embodiment of the device for use in the method of the present invention;
FIG. 2 is an end view taken along lines 2--2 in FIG. 1;
FIG. 3 is an exploded view showing the parts of the probe of the device of FIG. 1 prior to assembly;
FIG. 4 is an exploded view showing the parts of the collection tube of the device of FIG. 1;
FIG. 5 is a schematic view showing the device applied to the skin in the practice of the method of the present invention; and
FIG. 6 is an illustration showing the contusion formed upon the skin.
In FIG. 1 to 4 of the drawings, there is shown a preferred embodiment of a device which can be used in the practice of the method of the present invention. The device 10 as seen in FIG. 1 consists of a probe 11 and a collection tube 12.
Referring to FIGS. 1 to 5, it can be seen that the probe 11 includes a hollow-cylindrical housing 13 which is open at one end 14 to receive the collection tube 12. The other end 15 of the housing is closed except for a tubular central inlet 16. As seen only in FIG. 5 the inside of the inlet 16 is threaded as at 17 to receive a needle assembly 18 having a hub 19. When the needle assembly 18 is secured in the inlet 16 as seen in FIG. 1 a sharp piercing end 20 of a needle 21 projects into the housing 13. A tubular projection 22 extends outwardly from the other end of the hub 19. of the needle assembly. As seen best in FIG. 5 the hub 19 fits wihtin a central bore 23 of a cup-shaped member 24, preferably of resilient plastic, wich is part of the tip 25 of the probe 11. As seen only in FIG. 3, the tip 25 also includes a solid mushroom-shaped deflector 26, preferably of rigid plastic, which has as stem 27 adapted to fit loosely into the other end of the bore 23 of the cup-shaped member 24 and a duck-billed valve 28 for keeping liquid properly positioned in the front end of cup 24 until vacuum is applied. A septum 39 and cap 38 can be used to contain the liquid until use.
As seen best in FIG. 2, when the deflector 26 is properly positioned in the cup-shpaed member 24 an opening 30 exists between the outside of the head 26a of deflector 26 and the inside of the recess 29 of the cup-shaped member 24.
Turning to FIGS. 4 and 5, it can be seen that the collection tube 12 includes a glass or plastic tube 31 which is closed at one end 32 and open at the other end 33. In the completely assembled collection tube 12, as seen in FIG. 1, the open end 33 is closed by a solid resealable stopper 34. The inner end of the stopper 34 has a central recess 35 seen only in FIG. 5 in which a small fluid collection trap 37 for the skin fluid is locked in place by friction. The interior of the assembled tube 12 including the trap 37 is at a reduced pressure or vacuum. The trap 37 can be made of a gas permeable plastic or have a vent hole or notch 36 to insure that its interior is also at a reduced pressure (e.g., 100-400 mm Hg.).
As seen in FIGS. 1 and 5 the cylindrical housing 13 is sized to serve as holder for the vacuum tube 12. In FIG. 1, the tube 12 is shown sealed and in FIG. 5 the tube 12 is shown advanced within the holder 13 with the needle assembly 18 piercing the stopper 34 of the tube 12. Prior to preloading the cup-shaped member 24 with coating liquid the tube 12 can be partially advanced so that the needle point 20 is closed by but has not completely pierced the resealable stopper 34. The mouth of the cup 24 can be sealed with the septum 39 and the tearable aluminum cap 38.
In the preferred practice of the method of the present invention an area of the skin of the donor is first pretreated for one minute with a solution to clean off dead cells and to extract lipid materials from the surface. The cup 24 in the probe tip 25 of the device 10 is preloaded with a coating liquid then quickly pressed against the pretreated skin as seen in FIG. 5. The liquid in the cup 24 in the probe tip 25 forms a liquid coating on the skin which increases skin permeability and assits the transfer of the skin fluid to the vacuum tube. Keeping the outer portion of the cup-shaped member 24 in contact with the skin the collection tube 12 is then advanced within housing 13 until the point 20 of the needle 21 penetrates the resealable stopper 34. Because of cooperation of the deflector 26 and the reduced pressure in the collection tube 12 a contusion 40 is formed similar to that illustrated in FIG. 6 and the liquid on the skin, including any tissue fluid extracted from the area of the contusion within the boundary of the recess 29, is sucked through the opening 30 and transported via the needle assembly 18 into the collection trap 37.
Although a specific device for forming the contusion and collecting the desired components has been illustrated and described, it will be apparent to those skilled in the art that other types of devices which form a contusion and/or provide vacuum assistance can be used in the collection of skin fluid in accord with the teaching of the present invention. Devices that have been constructed and successfully tested include those in which the probe tip is comprised of cups of elastic rubber or rigid plastic which are nipple-like or cone-shaped and those in which the probe tip includes in place of the mushroom-shaped deflector, a member which is star-shaped, or formed of concentric rings or beads.
The preferred collection tube 12 is an evacuated tube and it is surprising that the evacuated tube can both cause a contusion and extract measurable amounts of tissue fluids. The vacuum, if desired, also could be supplied by a vacuum pump (mechanical, electric, aspirator) hydraulic fluid movement, a syringe, chemical vacuum or even mouth suction. The components possibly could also be collected from the area of the contusion without vacuum assistance, if desired. It does appear, however, that the collection of skin tissue fluid is enhanced and made reproducible by reducing the atmospheric pressure on the skin within the area of the probe tip with the liquid in contact with the skin. This is not possible with any other patented device.
Devices could also be employed in which the needle assemlby is simple a channel or tube with a piercing tip and which includes a control valve or clamp. In addition, the collection trap could be a series of connected tubes joined by a constriction, a port leading to a diagnostic device, or simply a piece of sponge-like material which could be used as such in a diagnostic test or from which the collected tissue components could be recovered.
Although the use of a single pretreatment solution has been described, additional pretreatment solutions could be used. They might be applied by spraying or in a gel-like binder, or with a bandage-like applicator.
In the preferred practice of the method of the present invention, the skin is first washed with a solution and then treated with a coating liquid comprised of trichlorotri-fluoroethane (Freon TF; Du Pont).
The Freon TF washing solution, which removes dead cells and contaminants, is composed of a liquid active agent to permeate the skin. The solution could also be used as a coating liquid and may contain other solvents such as polyvinyl acetate, acetone and dimethylsulfoxide (DMSO) to change the permeability of skin membranes, an analgesic and a gel or cream of high viscosity to help the probe tip form a seal with the skin. Another vehicle solution which could be used in the cup 24 might also contain anticoagulants, hormones and buffering with carrier molecules to avoid nonspecific losses due to binding or deterioration and to promote preservation, and disinfection.
The preferred solution contains the following ingredients:
______________________________________ Generic Name Preferred Concentration Active Component Concentration Range, Active______________________________________COMPONENTS OF THE WASHING SOLUTION(a) FREON TF 100% 100% (Trichloro- trifluoro- ethane)COMPONENTS OF THE VEHICLE SOLUTION(b) Tetrahydrozo- .025% w/v 0.02-.05% line hydro chloride(c) Alkylaryl 3.0% v/v 0.05-5.0% Polyether Alcohol(d) Heparin-Ammonium 50 IU/cc 5-100 IU/cc(e) Phosphate .05 M Buffer pH 4-8 Buffered (pH 7.2) Saline .45 M NaCl 0.2-.9 M Solution (PBS) NaCl______________________________________
In addition to tetrahydrozoline HCl (0.05%) other vaso-constricting or vasodilating compounds may be used, such as phenylephrine hydrochloride. Vasodilators are preferred.
In addition to the surface active agent used other surface active agents providing the same function and not having any detrimental effects can also be used. Representative of such surface active agents are the following: Guanidinium chloride, mercaptoethanol or other nonionic or ionic detergents.
The preferred anticoagulant solution contains ammonium heparin. However, other anticoagulants which may be used include the following: ethylenediaminetetraacetic acid (EDTA) (0.02%), sodium heparin, sodium citrate, streptokinase or streptodornase.
Other cleansing agents than FREON TF may be used such as methyl salicylate 15.0% in methanol 70% v/v, ethanol, paraben, methylparaben, providone iodine, phenol (0.5%) antibiotics, dimethyl sulfoxide, acetone, isopropyl alcohol, chloroform, polyvinylacetate, polyvinyl alcohol, mineral oil, propylene glycol, or polyethylene glycol. In addtition an antibubble agent may be added. If desired, a pain depressing agent such as benzocaine or triethanolamine salicylate or a heat stimulating agent like methylsalicylate also may be included along with volatile solvents such as ether. Still further the addition of mild enzyme solutions such as trypsin may be useful, depending on the component(s) desired in the sample obtained.
The preferred method of collecting skin tissue fluid components comprises:
(a) Applying FREON TF solvent (1-2 drops) to a portion of hairless skin such as the forearm for 10 seconds, wiping with a clean tissue.
(b) Applying 375 microliters (μl) of a hypotonic buffered solution containing phosphate buffer 0.05 M, pH 7.2--about 30 seconds.
(c) Pressing the prode tip 25 (cup 24 preloaded with the solution used in b for forming a liquid coating), firmly to the treated skin.
(d) Forming a seal and contusion by activating the vacuum by moving the tube 12 within the housing 13 until the needle 21 pierces the stopper 34 of the vacuum tube while maintaining contact with the skin for 0.5 minutes.
(e) Stopping the action by pulling the probe tip away to break the vacuum. The skin sample is thus collected in the trap.
(f) Wiping the skin area with alcohol or a suitable antiseptic.
The preferred method results in the skin being visibly affected. It is reddened and a small "hickey" or contusion is formed. It appears that only microcapillaries are broken allowing the contusion to quickly heal and greatly reducing the risk of infection (skin punch biopsies were taken and evaluated by a certified clinical pathologist as noninvasive). A small sample, 300 μl, of sample is trapped in the collection tube. The skin is obviously still intact. There is no bleeding evident, no scab formation takes place, no clotting evidence appears, no visible scratches, nicks or piercing of the skin occurs and no infections result. There is no pain, only the reddened area or contusion which usually disappears within 10 minutes to 2 days.
The skin fluid contains many interesting chemical components some of which are given in the following chart:
Data obtained by sending the "skin" samples to commerical clinical testing laboratories and to analytical testing labs. The skin tissue fluids thus collected were diluted 2000-3000x by the method used.
______________________________________Test #1a Test #1b Test #2 Normal Range______________________________________Glucose .05 .08 .05 70-110 mg/dlBUN 2 .8 8 8-30 mg/dlCalcium .1 .8 3.6 8.5-10.8 mEq/LIron 9 NT 23 40-150 μg/dlPotassium .9 1.2 1.9 3.5-5 mEq/LSGOT 4 4 9 7-27 IU/LSGPT 10 1.7 12 8-30 IU/LSodium 4 18 14 135-145 mEq/L______________________________________ Test #1a and Test #1b are the same sample tested at two different Labs.
Test #2 is a sample which has been concentrated about 10x, and tested at the same lab as Test #1a. This sample was lyophylized and the nonstable enzymes and gases may be lost. The sample was also analyzed for proteinaceous components and carbohydrates by colorimetric methods and specific drugs and chemicals by commercial or other assays, such as high performance liquid chromatography (HPLC).
In addition to the specific device shown in the drawings for making the contusion, other types of devices can be used including mechanical devices to form the superficial contusion such as gentle pinching or pressing devices, with or without vacuum.
The trap 37 can be fabricated in many useful configurations. Traps have been constructed with minor changes in shapes that will perform the following functions.
1. Filtration of the specimen.
2. Column purification.
3. Mixing with a series of chemicals in steps.
4. Storage of reactants separately, yet allowing easy mixing.
5. Growing microorganisms.
Post treatment of the skin after the contusion with 70% isopropyl alcohol helps prevent any possibility of infection or irritation. In addition, post treatment of the sample aids in preparing and preserving the specimen for use in a diagnostic test. For example: the sample may be further diluted with buffers such as phosphate-saline, Tris-HCl, hepes, boric acid-soidum borate. The diluent can contain protease inhibitors (i.e., dithiothreitol, 1 mM) or other ingredients to help purify the component to be tested (i.e., Affigel-Blue, Biorad Co., to remove albumin; Protein A, from staphlococcus A, to bind up IgG; Calcium Chloride to help remove fibrin).
Losses of desired constituents by nonspecific absorption can be prevented by precoating the internal surfaces of the collection device components with silicon or proteins. Preservatives such as paraben or antibiotics also may be used. The sample can be stored frozen.
The permeability of the skin (membranes of the epidermis and dermis) for diffusion of components is variably dependent upon:
1. The balance of blood pressure and atmospheric pressure;
2. The integrity of the membrane barrier;
3. active transport;
4. relative concentration, solubility and size of components;
5. hydrophobic and ionic forces between macromolecules (i.e., presence of lipid associated materials);
6. temperature; and
7. pH (hydrogen ion concentration) and ionic strength.
The method of the present invention through use of a washing solution and vehicle liquid and vacuum can suitably adjust these variables to obtain a sample of body fluid directly through the skin without pain or discomfort.
The practice of the present invention is further illustrated by the examples which follow.
Subject - Male, Age 45. A small (about 1 cm2) area of the skin on the forearm was treated with Freon TF (10 seconds) followed by 375 μl drops of solution phosphate buffered saline (PBS) (0.05 M Buffer pH 7.2, 0.45 M NaCl) for 10 seconds in the probe tip cup of the mechanical device shown in FIGS. 1 to 4 applied to the skin. The collection tube assembly was moved within the housing to activate the vacuum. Suction was maintained for 0.5 minutes and halted by pulling away the probe tip from the skin. Thirty-eight replicate samples were taken.
The skin was not broken; and only small superficial contusions (hickies) resulted that disappeared in 48 hours.
The samples obtained in the collection trap were removed by separating the tube and unplugging the rubber stopper. The samples were tested for glucose.
An average of 0.05 mg/dl (500 PPB) were detected by an enzymatic colorimetric assay. The average coefficient of variation was 16%.
Glucose was detected at about 0.05 mg/dl by a colormetric reaction using a specific hexokinase glucose 6-phosphate dehydrogenose assay.
Protein was determined as about 100 mg/dl by color change of the indicator 3', 3", 5', 5"- tetrachlorophenol - 3, 4, 5. 6 - tetrabromosulfopthalein.
Subject - Female, Age 39. A small (about 1 cm2) area of the skin on the forearm was treated with 375 μl of solution PBS for about 10 seconds. The cone-shaped probe tip of a device made from nonflexible plastic which was connected to a vacuum source (mechanical pump: 250 mm of Hg) was pressed against the treated skin for 60 seconds with a fluid trap in series. About 300 μl of sample was recovered. The sample was tested for blood components as follows:
Carbohydrates were detected by high performance liquid chromatography (Dionex AS6 Column; pulsed amperometric detector in 0.15 M NaOH).
Thirty-three other determinations were made using various other mechanical devices described and profiles of carbohydrates in sample solutions was determined empirically to be of the same pattern (i.e., 6 major peaks) for all persons.
A male 43 year old was sampled for total bacteria per centimeter square (cm2) of skin.
A preferred device as seen in the drawings was sterilized with 70% ethanol, preloaded with sterile saline, and applied to various skin sites, arm, leg, foot, to collect material.
A comparison of "dirty" and freshly washed skin was made by culturing the resulting samples on a rich nutrient medium. As expected, the uncleansed skin had much more detectable bacteria. Even freshly cleansed skin contained about 1000 bacteria per cm2. These were nonpathogenic organisms; but the method used in conjunction with the appropriate test could be used to diagnose pathogens. Thus, glucose in samples must be assayed immediately or stored so as to preserve.
Six nondiabetic patients and six diabetic patients were tested using the preferred device and method of the present invention to collect specimens. A colorimetric assay for glucose was employed.
Many assays were performed for each individual. The results were compared to direct blood tests using a similar assay. The results indicated that total glucose values obtained with the device and method of the present invention paralleled the blood values obtained from direct blood tests when plotted against time before and after glucose intake. Triglycerides were also elevated after glucose intake, and were detected in the samples.
A hypotonic saline pretreatment solution was used allowing 30 seconds contact before forming the contusion for most tests. Total glucose results also could be stimulated by using other additives such as glycerol. When no liquid pretreatment was used, no glucose could be found in the specimens collected. The use of other types of devices (i.e., without a deflector which pinches off an area of skin) gave irreproducible results.
A forty-three year old male was tested using the device and method of the present invention. The device was kept in contact with skin for extended periods of time. A variety of liquid pretreatments were used with essentially the same result. After about sixty minutes of application, a blood blister was raised on the skin and a pink (hemoglobin containing) solution was obtained.
The resulting lesions took more than one week to disappear. Use of the device for short periods of less than two minutes was always noninvasive.
A forty-three year old male was tested, using the method and device of the present invention and various pretreatment solutions for the collection of electrolytes (sodium and potassium). Ion specific electrodes indicated the presence of the electrolytes in the transudates collected.
In several tests the ratio of thw two ions appeared to correlate with blood levels. Dimethylsulfoxide was found to increase the yields of electrolytes five-fold over the use of aqueous pretreatment solutions. Some more aggressive (i.e., detergent containing) solutions were found to encourage proportionately higher potassium levels, indicating cell disruption. A variety of cell debris was observed in samples; therefore, tests specific for cell contents could be performed.
A forth-three year old male was tested, with the device of the drawings using hypotonic saline as a pretreatment solution, for amino acids and protein in transudates. In a short time of application (30 seconds) equivalent reproducible amounts were detected as compared to 5 minute applications. Since phenylalanine (PA) is one of the amino acids, it is possible that this approach could be used to detect PA elevated due to phenylketonuria (PKU). Other genetic defects or inborn errors of metabolism probably could be diagnosed using specific tests.
It will be apparent to those skilled in the art that there are many reasons why it may be preferable to use the present invention rather than pierce the skin with a lance or needle. The procedure of the present invention is non-invasive and therefore has less chance of secondary infection when components are presterlized and used in a sanitary manner. The method is painless. The extrudate may be obtained by the donor or another person in a one-hand operation, without technical expertise, and is essentially foolproof. The site of extraction is less precise than that required for phlebotomies. Therefore, a sample could be obtained more easily from infants or others with small and damaged veins or in emergency silutations. In addition, the method and device are of great potential value in the development of diagnostic tests that require plasma-like or other fluid for home health care and consumer performed diagnostics.
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|U.S. Classification
|600/578, 604/316, 604/290
|International Classification
|Cooperative Classification
|European Classification
|Dec 24, 1992
|Fee payment
Year of fee payment: 4
|Dec 9, 1993
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|Jan 6, 1997
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|Jan 23, 2001
|Maintenance fee reminder mailed
|Jul 1, 2001
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Effective date: 20010704


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After a quiet spell on the blog the last few weeks… how about a lovely little Christmas inspired wedding sneak peek to kick the holiday weekend off right!
Here goes…
Our last wedding of the year was just before Christmas and we love how Stefanie & Carsten embraced the elegance and festive spirit of TPC Sawgrass during the holiday season. It was the perfect end to our 2011 wedding season and we were so happy to have spent this day with such a sweet couple. Here are just a few of our favorites from their wedding day. I hope you are all enjoying a wonderful New Year's weekend and can't wait to share so much more with you soon! There are lots of fun things to come in 2012!
Happy New Year's Eve!

subset: commoncrawl


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Thursday, 20. November 2014
TOP 50 Sports Industry Newcomers Selected
- 50 Winners Selected From 431 Entries
- Overall Winner onoo from Munich
ISPO BRANDNEW is the world's largest sports industry newcomer competition. In cooperation with international experts ISPO recently honored 50 winners for the 2015 edition from 431 entries in eight different categories. Overall Winner is Munich-based onoo brand, offering products like Teflon-coated Loden jackets that merge style and functionality. The promising top 50 newcomers will enjoy an exhibit at the ISPO BRANDNEW Village in hall A1 allowing them to present their company and products at ISPO MUNICH and thus to the entire sports business network.
This year marks the 27th time ISPO searched for the most exciting sports industry start-ups. 431 new brands in business for four years or less entered the competition for 2015. The independent jury consisting of former winners evaluated all submissions and selected and Overall Winner, seven winners in the categories Accessories, Hardware Summer, Hardware Winter, Style, Wheeler, Sportswear, Digital, as well as 41 additional finalists. They also presented the associated Social Awareness Award.
Tobias Gröber, Executive Director Business Unit Consumer Goods Exhibitions at Messe München GmbH: "The high number of entries to the 2015 competition clearly demonstrates the sports industry's unbroken innovation potential. As for the many winners in the past ISPO BRANDNEW assists the latest winners with a successful market entry. We are looking forward to find out which brands will become fully established on the market in the coming years."
From February 5 to February 8, 2015 visitors to ISPO MUNICH 2015 will be able to view the Overall Winner, winners and finalists at the ISPO BRANDNEW Village in hall A1.
Overall Award: Onoo, Germany, 2014
Stylish and functional jackets for active urban people
The jackets produced by the young Munich-based company Onoo combine natural and technical materials in unique designs and styles that offer maximum freedom of movement for active urban people. With the aim of offering the customer a very special product, Onoo uses only the best materials that provide the characteristic looks, functionality and also the special touch of the jackets. The result is technical urban clothing that looks modern and relaxed, at the same time it's breathable and protects against wind and weather. The "Sendling" jacket, as an example, is made from fine felted wool coated with Teflon.
Accessoires Award: HEXO+, France, 2014
The drones innovation for exceptional footage
The innovative HEXO+ drone is an autonomous flying system for exceptional aerial footage that will radically change the way action sports are filmed. Connected with the GPS function of a smart phone, the drone follows the skier or snowboarder, allowing aerial filming in the most remote places. Co-founder of the company is the French pro snowboarder Xavier de Le Rue. His first breathtaking sequences of some of his own freeride lines filmed with the drone eliminate all doubts about the benefits of this product. It comes as no surprise that the start-up that had initially asked for 50,000 US$ on Kickstarter.com quickly raised starting capital exceeding 1.3 million.
Hardware Summer Award: Tentsile, England, 2010
The tree house tent for outdoor enthusiasts
Tentsile Tree Tents are tree houses outdoorers can take with them anywhere. Depending on the condition of the terrain, the tree tents can be pitched on the ground like traditional tents or without ground contact between trees like a hammock. The user will be comfortable and safe, no matter whether the ground is flooded or rough, or whether there are bugs or other animals around. The spacious Tentsile Stingray is a three-person tent with floor hatch and front door access, a removable flysheet, and a full insect mesh roof for maximum ventilation.
Hardware Winter Award: Ice Rock, Russia, 2013
The lightest ice axe of its class
With the IDOL, Ice Rock developed an extremely lightweight ice axe made from carbon fiber for ski tourers, freeriders, climbers, and other outdoor athletes. The company is based in Kirov in Northern Russia, a town that hosts a stage of the World Ice Climbing Cup. Due to their long experience in working with carbon fiber, Ice Rock managed to develop a shaft with variable wall thickness. It's extremely robust, prevents vibration, and avoids heat loss of the user's hand. The tapered shape protects the axe from excessive overload and damage. The rear part of the pick is made of steel, the spike of light aluminum alloy, and the tip of titanium. With a total weight of 188g, it's the lightest ice axe of its class.
Style Award: Kraft & Ulrich, Germany, 2013
Stylish storage for sports equipment
Is there a stylish way to store bikes, surfboards, skateboards, or snowboards at home in your apartment? Yes there is: With "Harper", a crowdfunding project initiated by the Hamburg-based brand Kraft & Ulrich. The flexible wall mount system can also be used as a space-saving shelf or wardrobe. Harper consists of a plywood base with timeless and fashionable oak finish. In addition to simple sticks that go right into the base plate, there are various hooks, metal shelves, wooden boxes as well as a fabric loop that allow you to store sports equipment and accessories in a simple, stylish, and space-saving way. The high-quality system is made in Germany, infinitely modular and a must-have for both athletes and design lovers.
Wheeler Award: Zehus, Italy, 2013
The innovative Pedelec kit
With Bike+, Italian brand Zehus offers a kit that converts regular bikes into Pedelecs. During strenuous passages, Bike+ is automatically activated to support the cyclist. The system needs no recharging from grid since the energy is recovered during cycling and fed directly into the Bike+ power pack. Motor, batteries and sensors are all integrated in the lightweight hub that is mounted on the rear wheel. There are no additional parts or cables. The system is customized and controlled via Bluetooth and a smart phone app. Bike+ fits all bikes with tires from 20 to 29 inches.
Sportswear Award: Wearable Life Science, Germany, 2014
Sportswear with integrated muscle stimulation
With the Antelope fitness line, Wearable Life Science offers a revolutionary and mobile sports outfit with integrated electrodes, sensors, and control unit that provides the maximum possible flexibility during a workout. Based on EMS (electro muscle stimulation), the clothing gives additional muscle stimulus during sports, which results in increased training efficiency and may lead to improved posture and general fitness. With products for running and biking, Wearable Life Science is the first brand to open doors for complementary integration of EMS technology into any athletic activity in the outdoors. The clothing promises faster progress in a shorter period of time for a reasonable price.
Digital Award: Bragi, Germany, 2013
The in-ear fitness tracker
The Dash are the world's first cordless in-ear stereo headphones with smart functions. Thanks to its biosensors, The Dash is also a fitness tracker. Without an additional device it tracks pace, steps, cadence, heart rate, calories, and oxygen saturation. During the workout, the user receives real-time acoustic feedback. And there's certainly sound, too! The Dash plays music from an external mp3 player through a Bluetooth connection or use the integrated 4 GB music player. The audio quality is impressive and there's an active noise isolation function.
Social Awareness Award: Headição, Germany/Brazil, 2013
Sportive support for underprivileged kids in Brazil
The charity project Headição - Balls 4 Brazil was initiated by Headis inventor René Wegner and his team. Headis is similar to table tennis, but played with the head and with a special ball. The goal was to offer sports activities to underprivileged children and teenagers who usually do not have access to sports or creative activities. In May 2014, the team visited orphanages and other social institutions, built Headis tables from water barrels and wood, handed out gear, and organized workshops. The initiators wanted to show that a lot of good could be done without spending millions of cash. The current goal is to sustainably establish the project in Brazil and reach out to other countries as well.
All BRANDNEW Winners in detail: www.brandnew.ispo.com


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Assessment |
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Methods | Statistics | Clinical | Educational | Industrial | Professional items | World psychology |
Cognitive Psychology: Attention · Decision making · Learning · Judgement · Memory · Motivation · Perception · Reasoning · Thinking - Cognitive processes Cognition - Outline Index
Christophorus Henricus Diedericus Buys Ballot (October 10, 1817 – February 3, 1890) was a Dutch chemist and meteorologist after whom Buys Ballot's law and the Buys Ballot table are named.
Buys Ballot was the son of a Dutch Reformed minister, born in Kloetinge, Netherlands. He attended the Gymnasium at Zaltbommel and the Hogeschool (now University) of Utrecht. After receiving his doctorate in 1844, he became lecturer in mineralogy and geology at Utrecht; he added theoretical chemistry in 1846. In 1847 he was appointed professor of mathematics and from 1867 until his retirement he was professor of physics.
Buys Ballot tested the Doppler effect for sound waves in 1845 by using a group of musicians playing a calibrated note on a train in the Utrecht-Amsterdam line.
He died in the Dutch city of Utrecht.
Buys Ballot is best known for his accomplishments in the field of meteorology, specifically the explanation of the direction of air flow in large weather systems. Furthermore, he founded the Royal Dutch Meteorological Institute in 1854 and he remained its chief director until his death. He was one of the first to see the need for international cooperation, and in 1873 became the first chairman of the International Meteorological Organization, a precursor of the World Meteorological Organization (WMO).
Buys Ballot's law states that if a person in the Northern Hemisphere stands with his back to the wind, the low atmospheric pressure is found to his left. His main research effort in meteorology went into examining long-time series for regularities; he was more concerned with establishing the regularities than in explaining them. He made no contributions to the theory of meteorology which is perhaps surprising given his training in physics. The contrast with his American contemporary, William Ferrel, who discovered Buys-Ballot's law slightly earlier, is striking.
Buys Ballot devised a tabular method for investigating periodicity in time series. In 1847 he used the table now named after him to determine the period of the sun's rotation from daily observations of temperature in the Netherlands from 1729 to 1846.
- Harold L. Burstyn "Buys Ballot, Christoph Hendrik Diederik" Dictionary of Scientific Biography volume 1, p. 628, New York: Scribners 1973.
- E. van Everdingen C. H. D. Buys Ballot 1817-1890 The Hague 1953.
- O. B. Sheynin On the History of the Statistical Method in Meteorology, Archive for the History of the Exact Sciences, 31, (1984-5) 53-95.
- J. L. Klein Statistical Visions in Time, Cambridge: Cambridge University Press 1997.
- Houdas, Y (April 1991). Doppler, Buys-Ballot, Fizeau. Historical note on the discovery of the Doppler's effect. Annales de cardiologie et d'angéiologie 40 (4): 209–13.
- Jonkman, E J (1980). Doppler research in the nineteenth century. Ultrasound in medicine & biology 6 (1): 1–5.
External linksEdit
- M. Buys-Ballot, "Note sur le rapport de l'intensite et de la direction du vent avec les ecarts simultanes du barometre", Comptes Rendus, Vol. 45 (1857), pp. 765–768.
|This page uses Creative Commons Licensed content from Wikipedia (view authors).


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A CHARITY is calling on daredevils to take ona zipslide challenge at Salford Quays later this year, to help in the fight against muscle-wasting conditions.
The Muscular Dystrophy Campaign is looking for participants to zip 250 metres across the Manchester Ship Canal, from the Imperial War Museum North to the Lowry Centre, on October 4.
Funds raised through the challenge will back the charity's vital work funding research into treatments for muscular dystrophy and related neuromuscular conditions and supporting families affected by them.
Participants are being asked to raise at least £200 in sponsorship, with each receiving fundraising support and a charity branded t-shirt to wear on the day.
Further information and entry forms are available by e-mail from firstname.lastname@example.com or by calling 01244 536551.


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- Homogeneous data arrays containing elements of the same type
- Multimedia — audio, video and graphics files
- Interim data for internal use (logs of various types, caches)
- Streams of calculated data of various types (e.g. recorded video stream or massive computation results)
- Documents (simple or compound)
The ways for storing such a data are as follows:
- Files in file system
- Databases
- Structured storages
- Archives (as a specific form of structured storage)
- Remote (distributed, cloud) storages
Homogeneous data arrays
Homogeneous data arrays contain elements of the same type. Examples of a homogeneous data array may be a simple table, temperature data over time or last year stock values.
- For homogeneous data arrays, regular files do not provide possibility for convenient and fast search. You have to create, maintain and constantly update special indexing files. Modification of the data structure is almost impossible. Metainformation is limited. There is no built-in run-time compression or encryption of data.
- Relational databases are well suited for homogeneous data. They comprise a set of predefined records with rigid internal format. Main advantage of relational databases is an ability to locate data quickly according to specified criterion, as well as transactional support of data integrity. Their significant shortcoming is that relational databases will not work well for large-size data of variable length (BLOB fields are usually stored separately from the rest of the record). Moreover, keeping data in relational databases requires: a) use of specific DBMS, which limits severely portability of the data and of the application itself, b) pre-planning of database structure, including interrelational links and indexing policy, c) researching details of peak loads is required for efficient database development, which also may be a serious overhead.
- Structured storages are somewhat analogous to a file system, i.e. storages are a specific set of enveloped named streams (files). Such storage can be stored at any location, i.e. in a single file on a disk, in a database record, or even in RAM. The main advantage of this approach is that it allows efficient adding or deleting data in an existing storage, provides the effective manipulation of data of various sizes (from small to huge). The storages represent separate units (files) and therefore can be easily relocated, copied, duplicated, backed up. There is no need to track all files generated by an application. Moreover, journal keeping makes it possible to restore content completely or partially, thus eliminating accidents or failures. The disadvantage may be relatively slower search inside these huge data arrays.
- ZIP archives, as a specific form of the structured storage, can be used for storing homogenous data arrays, but only in case when the most of access is read-only. Standardized nature of ZIP format makes it easy to use, especially in cross-platform applications, but this format is not suitable for the data to be modified after packing, so adding and deleting of data is a time-consuming operation.
- Remote and distributed storages are the next level of storage in which actual data location and data access are provided by specific layer used for encapsulating of access mechanics. In such storages data can actually be stored in databases or be distributed among different file systems, but the actual storage organization does not matter for an end-user. The user observes only a set of objects accessed through an API, or, as a variant, through file system calls. Good example is cloud storages. These types of data storages are to be used in large software complexes. Among other advantages one can mention unified data access without a need to think about actual ways how data are stored. Its disadvantages — they cannot be efficiently managed and controlled, and backup or migration of data is complicated.


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Recent JPG Live Stories
Latest Photo Links
Photos of the Week: 8/12–8/18 - The Atlantic
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Q: My sister in-law recently gave me a Canon EOS 10D digital camera body. Having only used point and shoot cameras, what would be a good beginners lens to get for this camera? Should I get kit lens to start with?
A: Do you know?


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Monday, October 21, 2013 - 22:26 PM
New Meytal Video
Views: 5511
Meytal Cohen
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Pretty cool
Here's the latest video upload from Meytal, tackling some Slipknot.
I liked what Meytal had to say about this - This song definitely made me a better player. when I first decided I was gonna cover it, I could barely play the opening fill, not to mention, the one bar double bass part, just wasn't in shape... but i made up my mind and went for it! and by the end of this shoot this was a total piece of cake. crazy what inspiration will do for you.


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Montana Mountain Muffins Recipe
These coffee flavored muffins are wonderful for either breakfast or just a snack. No matter when you serve them, they won't last long.—David Wallace-Menard, Shepherd, Montana
- 4 cups all-purpose flour
- 4 cups whole bran cereal
- 1-1/2 cups sugar
- 4 teaspoons baking powder
- 3 teaspoons baking soda
- 2 teaspoons salt
- 2 cups cold coffee
- 2 cups whole milk
- 6 large eggs, beaten
- 1-1/2 cups vegetable oil
- 2 teaspoons vanilla extract
- 2 cups raisins
- 1. In a large bowl, stir together the first six ingredients. Combine the remaining ingredients; add to the dry ingredients just until moistened. Cover and refrigerate until ready to bake. Batter will keep for several weeks.
- 2. When ready to bake, stir batter and fill greased muffin tins two-thirds full. Bake at 350° for 20 minutes or until muffins a toothpick comes out clean. Yield: about 5 dozen.
Nutritional Facts
1 each: 145 calories, 7g fat (1g saturated fat), 22mg cholesterol, 180mg sodium, 19g carbohydrate (9g sugars, 1g fiber), 3g protein.
Reviews for Montana Mountain Muffins
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© 2017 RDA Enthusiast Brands, LLC


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Thursday, May 11, 2017
Sunday, November 27, 2016
It's Only Awkward...
Even for those with a front row seat to our lives, it has come as quite a shock that Kirk and I have decided to separate. To be honest, it even came as a shock to us. It's not that we were unaware of the problems we need to work on. Rather, the realization that we each need some space to become stronger individuals came seemingly out of nowhere.
As has always been the pattern in our marriage, the decision was confirmed as things quickly fell into place. I was able to find a basement apartment only five minutes from home with a separate entrance and a private bathroom. The landlord allowed me to paint, and I was able to turn my room into a home of sorts -- at least a home base that gives Kirk and me the division we have decided is best for now.
So why the public announcement? Well, Kirk and I are already confusing our friends and family: attending parties together, sitting together in church, eating dinner together as a family most nights. As we know it will become increasingly obvious to others that I am not living at home, we decided it was best to deal with the common questions up front.
Q: "If you are separated, why do you spend so much time together?"
A: Well, because we like each other. Neither of us are angry about the problems we are working on. What we have essentially done is taken a step back to something like the dating stage where we want to spend the time together that we can, but then go back to our own houses at the conclusion of the date.
Q: "Why did Andrea move out?"
A: This one is a little more complicated. First, I'm the one who suggested that a separation might punctuate the importance of our need to make some adjustments before moving forward as a couple. But mostly, we are putting our kids first. This is the best way to minimize the logistical impact on the kids. In fact, in the two weeks since our separation, we have been able to successfully maintain the kids' routine with very minor adjustments.
Q: "How are the kids?"
A: While I admit that it is too early to determine long-term effects, they appear stable and confident in the situation as it now stands. We are encouraging honest communication on all sides and have tried to be as upfront with them as is appropriate. Their well-being is at the forefront of every decision we make.
Q: "What is your plan?"
A: Our plan is to acknowledge honestly that we, like all couple, have problems. We are going to start working individually on those issues that require personal attention and together on what we can. We will seek help and support from friends, family, church leaders, and professionals as needed. And we will mostly continue to do it quietly and privately as is our style.
Q: "How can I help?"
A: Treat us like a family, because we are one. Treat us like a couple, because we are one. Ask us questions if you need to know something. Let us keep our lives private if you don't. And remember what our friend Skyler says, "It's only awkward if you make it awkward."
Yes, we've separated.
Yes, it is really hard sometimes.
Yes, we'll reach out if we need it.
And yes, we're okay.
Also... Kirk says I am supposed to say he's awesome. So...
Kirk's awesome. :)
Sunday, October 9, 2016
Cry Uncle
Maybe the best part was the debriefing Jack led me through after the project was completed.
- Adam and Alex really enjoyed it; Dylan was bored to tears.
- Adam frequently pointed out that Jack was wrong. According to Jack, this was because his ideas were different than Adam's and so Adam deemed them wrong.
- Alex frequently pointed out that Jack was wrong. This was because Alex had checked the instructions, and Jack was wrong. According to Jack, Alex is a Casdorph.
Or maybe it was the two hours of quiet I got to myself to work on Empress marketing projects while they worked in the game room.
Or maybe it was looking through the pictures Elise took of the boys hard at work.
I guess I don't really have to choose an exact favorite moment, but rather just appreciate that the night happened completely without my involvement.
Thanks, Uncle Jack and Aunt Elise!
Tuesday, June 14, 2016
The Rest of my Keys?
He looked back at me, panicking. "You gave us more than just the fob?"
"Yeah, I handed the first guy my whole key ring. It has a carabiner, a small Eiffel Tower, a USB drive, and a few assorted keys?"
He was already moving toward his nearest associate, seeking out immediate backup. "Hey, do you know where this lady's keys might be?" I could immediately see the answer dawn on the poor guy's face, and he had not choice but to admit it.
"I think they got tangled up in the customer's before her. The Montero."
I laughed, knowing something they didn't know.
"Would that happen to have been the gentleman in the grey slacks and maroon button up?" I asked. "Because if so, I actually know him. He lives in the neighborhood across from mine, and it really wouldn't be that big of a deal to get them back from him."
And so it was that I left Discount Tire with a slightly lighter load (although I guess I technically traded it for the burden of the tire's diagnosis) and an odd text message to send.
"Brother Hatch, Discount Tire thinks they may have given my keys to you. Any chance you received an extra set?"No harm, no foul. Now I have my keys back and a pretty funny story to tell.
"Sure did! Just noticed as you said that."
Monday, June 13, 2016
And yet...
Last weekend, I spent the most amazing 24 hours all. by. myself. I mean, people were around. But not people I knew. I spoke only to strangers (a feat generally so terrifying that I struggle to ask a question at Home Depot) for 24 hours. To be fair, Kirk had to endure a two hour steady stream of words that flowed out of me like an unstopped dam when I returned home. But still. 24 hours alone. And I loved it.
I headed to Bear Lake to check out the Pickleville Playhouse and review a show for UTBA. I could easily have driven back home after the production, but I decided I would rather just camp out in the back of my car and drive home fresh the next morning. But then the more I thought about it (and checked out area attractions on my phone), the more I wanted to tack on extras to make the drive even more worth it. A museum. A cave. I had no real obligations on Saturday, so why not?
And so it came to be that I woke naturally to the sunrise over Bear Lake.
That I spent two delicious hours picking at my pancakes, sipping hot chocolate, and feeling way more important than I really am while I used my phone as a wireless hot spot and submitted my review.
That I traveled back to 1852 and got a one-on-one tour (and a million good teaching ideas) at the Oregon Trail museum.
That I enjoyed a 90-minute hike inside a cave... without having to worry about one of my kids destroying the natural formations.
And that I ended the day wishing that I could intentionally achieve the loose curls that resulted from sleeping in my car and hiking in the rain!
Sunday, May 22, 2016
I Don't Like You
In unison, Kirk and I responded, "No."
"Then what is for dinner?" he asked. As we chuckled, he rolled his eyes. Then he flatly proclaimed, "I don't like you."
Honestly, I don't blame him. This sort of a response is an every day occurrence, not just from parent to child but in adult to adult interactions as well.
For example:
A few weeks ago, Kirk came up the stairs after kissing the boys goodnight. "The kids have requested your presence."
He stood in the middle of the kitchen, Michelle and I forming two opposing points on a straight line cutting through his location. Standing equidistant from his point, we could not see each other. That didn't prevent us from speaking in precise unison, however, as we responded chorally, "I don't even have any presents."
I guess this is why Adam can accurately define words like "sarcastic," "facetious," and "rhetorical." And why I sometimes find his insistence that I speak with accurate consideration of the varied connotations of each word every bit as annoying in him as it is in his father.
It's a wonder we manage to get anything done around here. As I just mentioned that perhaps I will list the organ that is just taking up space in my music room and wonder aloud whether anyone else has organs listed on KSL, Kirk answers back, "I don't know... maybe kidneys?"
Just give it a few years, and I will have cultivated an entire army of soldiers who wield words as swords. And it will probably be me stuck with no comeback other than, "I don't like you, either."
Tuesday, March 1, 2016
Read, Write, or Play
Soon baseball season will be upon me, and this strangely calm moment I have found will be whisked promptly away. But for now, I am not in a show. And Kirk and the older boys have scouts on Tuesdays. And Dylan is just a really quiet human. Which means that each Tuesday, I find myself with an hour. One quiet hour. With which to do whatever I choose.
I have found that since discovering this hour, I usually spend my drive home contemplating just how to spend it. It is kind of like going to Kohls with only $10. There is so much I would love to get, but the budget will only go so far. I have to browse the entire store, trying everything on, making certain I have gotten the most out of my meager amount. Most of the time my options come down to three of my favorite activities. Do I want to spend my hour curled up on the couch with a book in my hand? Or perhaps seated at my laptop, my thoughts pouring effortlessly onto the screen. Maybe I could spend it in the piano room, a book of Broadway tunes held open by the weight of the conveniently nearby primer piano books.
Read, write, or play?
Or give up on choosing and just take a bath instead.


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DES MOINES, Iowa – Some of Des Moines' finest have to go more undercover after the department adopted a policy restricting body art.
The policy now says any tattoos, branding and intentional scarring on the face, head, neck, hands, exposed arms and legs are prohibited. Employees who already have tattoos are exempt — but they must provide photographs of their existing tattoos.
Des Moines' police union says the policy is unreasonable and has filed a grievance.
Stewart Barnes, president of the union, said the policy could narrow the potential pool of eligible officers.
"If you know that for the rest of your career you are going to have to wear a long-sleeved shirt or have your tattoos removed, you might think twice about applying for the job," he said.
Des Moines Police Chief Judy Bradshaw said tattoos distract from a professional image. She added that the department doesn't allow beards, either.
Chris Morgan, a West Des Moines police officer and former U.S. Marine, knows first-hand what it feels like to have to wear a long-sleeved shirt when it's 90 degrees outside to cover the tattoos on his forearms.
"I get so hot out there when I'm directing traffic," Morgan said. "I've sweated through my shirt and my vest."
In November, the Sioux City police department adopted a policy that says officers cannot get new tattoos on exposed body areas. New job candidates are allowed to have tattoos on exposed skin, but they can't get new ones after they're hired.
"We don't allow beards, either," Sioux City Lt. Marti Reilly said. "But we can ask them to shave those off. It's different with a tattoo."
In Ames, the policy says that officers and other employees hired after May 1, 2004, cannot have tattoos visible while in uniform, but those hired before the date are exempt, said Cmdr. Jim Robinson.
Barnes, the Des Moines police union president, said his tattoos sometimes help with his job by providing a common ground with young people.
"They come up to me and talk to me about tattoos," the 48 year old said.


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- Holidays
- Destinations
- Attractions
- Activities
- Interests
- Transport
- About
Rent A Bike in Sri Lanka is the most economical means of enjoying touring holidays in Sri Lanka. In the backdrop of changing terrain and climate of the compact island, holidays spent in riding a bike visiting numerous tourist attractions of Sri Lanka, is bound to bring in great joys and merriment to the serious bikers as well as to the motor bike riding enthusiasts.
Rent A Bike in Sri Lanka at Lakpura Travels (Pvt.) Ltd., Moratuwa
Lakpura Travels at Moratuwa caters exclusively to the foreigners with respect of Motorbike renting and motorbike touring in Sri Lanka. You may Rent A Bike on daily basis, weekly basis or monthly basis. You may Rent A Bike for a specific duration. You may Rent A Bike and request for a budget tour package so that Lakpura could make all your hotel bookings at the given cities or tourist attractions.
Rent A Bike safety precaution in Sri Lanka
Please note it is mandatory for all the motor bike riders and the pillion riders to wear helmets in Sri Lanka. The government stipulation is applied not only to the main roads but also to the every nook and corner of the island.
Terms and Conditions concerning Rent A Bike
Delivery of the Bike
We are ready to deliver you motor bike to the airport, to the hotel where you stay or any other location of convenience to you. The additional charge for this service is USD 30 (To pay in Advance)
Motor Bike Rider
(a) Hirer must hold Motor-bike license / International driving license valid at least for 12 months.
(b) In addition to the driver's license, a valid ID card/Passport/Credit Card or a Guarantor.
(c) Age limit: above 21 years.
(d) Helmets: 02 helmets per Bike are lent to the rider free of charge.
(e) The use of motor bike is restricted to the person concerned in the rental contract.
Payment to Lakpura Travels (Pvt.) Ltd.
(a) The Deposit and the Rental on Rent A Bike is required to be paid in advance.
(a) All Bikes are insured for the rider and the pillion rider.
(b) Third party liability is fully covered by the insurance.
(c) The rider or the renter should cover the personal injuries on their own Insurance coverage.
Security of the Motor Bike
(a) The security of the Motorbike is the responsibility of the Hirer.
(b) All rental motorbike are provided with lockable security cables.
(c) The security of the Motorbike is the responsibility of the Hirer.
Safety and damages
(a) You are requested to refrain from riding in beaches, sand dunes and similar terrain where the sand could be sprayed into the machine.
(b) The hirer of the motor Bike is liable to pay minor damages to the bike up to USD 150 in the event of an accident or damage.


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Hope your not suggesting that they stop trying? …
- Tags: 2ch, Exhibitionism, Goddesses, Image Gallery, Oppai, Pantsu
Comment on Goddess of 2ch: "You Don't Often See A Pair This Pink!" by Phantasm:
Hope your not suggesting that they stop trying?
Recent comments by Phantasm:
- Japan Animator's Expo's ME!ME!ME! "Incomparably Sexy":
Was that Stocking-chan?
- Mihiro Mikasa Cosplay Seductively Bold:
There's no smiling in titan slaying Mikasa! Toats out of character.
- Kantai Collection "Behind Japan Windows Tablet Boom":
And that is why you post dumb questions under an anonymous account.
- Top 20 Most Anticipated Anime of Spring 2014:
Sgt. Frog in da houseeee.
- Velvet Kiss Kanoko Kikuchiya Ero-Figures:
So they can muster a figure, but no show. Really! a decent ending in the manga would have been good, but noooo.


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Original Article Can Be Found Here
As a vivid Xbox fan, I believe I have often been too critical of Microsoft and some of their ideas (like in this article). In saying that, I believe that as a fan of the Xbox brand and Microsoft, I am in a great position to analyse the Xbox One reveal in an objective manor.
When I woke up on Wednesday morning (Australian time), and had a quick look at the new name of the Xbox, and what it looked like, I definitely had mixed feelings. I like the simplistic design of the console and Kinect, and the slick new redesign the controller has been given, but when I saw the name of the console my blood started to boil. For the whole day I stewed on the idea of the 'Xbox One'. "The One box you need in your living room," I thought to myself, sarcastically. To be honest, I was annoyed that I knew it was coming. I didn't want the focus of my video game console to be movies and music and other forms of media, I wanted it to play games and games and games. However, I waited until I watched the conference to properly judge the Xbox One.
When I watched the conference and heard Don Mattrick, President of Interactive Entertainment Businesses at Microsoft, announced the name of the new Xbox, 'Xbox One', I felt a sense of relief; a completely different feeling to the one I had been containing all day. It is hard to describe, but I had a kind of satisfied feeling inside me. No longer will the Xbox be called a video game console. Instead, it will be called an "All-In-One Home Entertainment System," able to play movies, and music, and video games, surf the web, etc. It will be the ONE box you need in your living room (sort of). The sense of relief was not because I finally knew what the next Xbox would be called, but because I knew it was no longer fair to criticise the Xbox for not focusing on games first. After all, the Xbox One is no longer a video game console, it is a 'home entertainment system' that will play video games.
The first speaker for the conference was Yusuf Mehdi. Before showing off the new Kinect and television features he talked about gaming. He said "we [Microsoft] love gaming," and he also said there would be "a lot more (games) at E3." Although it annoys most gamers, this was a smart idea by Microsoft. It is already a guarantee that the Xbox One will be able to play video games, and E3 is the perfect stage for a focus on games. Instead, Microsoft decided to focus on some things that they hope will make the Xbox One stand out as an entertainment system.
We saw some amazing improvements to the Kinect and its features, and how the Kinect can be used to control your TV shows, movies, and the way you navigate menus and find content. I feel the demo could have been cut down just a little (we understood how expanding and shrinking the screen worked after the fifth time), but the features shown off, that are unique to the Xbox One, look very promising. Furthermore, Snapmode, a feature where you can have multiple apps (e.g. a movie and Skype, or a sports program and fantasy results) running side by side, was one feature that has the potential to open up plenty of possibilities for the way movies and television shows are viewed in the future (Microsoft never showed it working with a game, but I assume it is possible). Also mentioned was the idea that you can be playing a game, pause it and start watching a movie, then go back into the game from where you left off when you are done with your movie. This will be great for games that feature few save points, or if you have to give your attention to someone else while a cutscene is running. It sounds a bit like what the PS4 and Vita will be and are able to do now, respectively.
Once the television features were concluded, Marc Whitten, General Manage of Xbox Live at Microsoft, came out to talk about the console itself. He talked about the system information of the Xbox One, but did not go into any detail. He mentioned that it has 8GB of RAM, 8 Cores, USB 3.0, a Blu-Ray Drive, 500GB of storage, and some other things, but he never really expanded on any of those features. In my eyes, this was a poor choice. Why just tip your foot in the water? I understand not revealing some of the CPU and GPU specs could be a marketing choice, but it left consumers wanting more.
I found it strange that two particular features were skimmed over quite quickly. The first was the three operating systems in the Xbox One: Xbox architecture, Windows, and the Xbox One architecture that connects them both; the second was the built in, "native," dedicated DVR and editing software so gamers can record their gameplay and upload it. The 'three operating systems' in one box intrigued me, but it was passed over with a tiny explanation. The DVR was just mentioned and then nothing else was said about it. Sony has yet to provide any detailed information about how their share button will work, so this would have been a perfect opportunity for Microsoft to get one up on them. It puzzles me why Microsoft did not go into more detail with some of their more unique features, it could have made a lot of people more interested in hardware- something it seemed the reveal was focused on.
Whitten also talked about the Xbox Live service. He mentioned that 300 000 servers would be ready for Xbox One, as opposed to the 15 000 for Xbox 360 at the moment. He mentioned how content could and would be stored in the cloud so you can access it anywhere, and that developers can use it to create bigger matches with more players and "living, persistent worlds." A "living, persistent world" sounds like something Destiny, Bungie's next game, is trying to do. Let's just hope they don't pull a Sim City.
While Whittens's presentation was more about the tech side of the Xbox One, it was poorly done. Lots of things were mentioned, but no details were provided for any of the new features. Microsoft explained so much about how the Kinect will work with movies and television, yet they didn't do the same for the gaming features or some of their unique hardware features. I know E3 is coming up, but gamers and tech fans, myself included, were hoping for more.
Finally, the part most of us had been waiting for, the games. Without going into too much detail, Microsoft had EA Sports' Andrew Wilson talking about their new Ignite Engine and showing a joint trailer for FIFA, Madden, NBA Live and UFC next-gen games; Phil Spencer, head of Microsoft Studios, talking about how the new features "make our platform the best place to create," and showing a trailer for Forza 5 and a live action trailer for Remedy's (Alan Wake) new game, Quantum Break; and Eric Hirshberg of Infinity Ward talking about Call of Duty: Ghosts and showing a trailer for the game.
The trailers were all great, and all the games looked spectacular, but I was left wanting more. Where was Halo? Where was Gears? Where was a new IP? Microsoft is probably saving them all for E3, but they could have at least tried to get a couple more third party developers to debut next gen games at the event. Even though I started by saying the Xbox One is no longer a 'video game console', when you advertise that your entertainment system can play games, people want to see them. Complaints aside, how good did Forza 5 and the EA Sports games look! As for Call of Duty: Ghosts, something about the establishing shots in the trailer did not look that 'next-gen' to me.
While there was a lot of information supplied to consumers during the reveal, plenty of things were left out; It was not until I read an article on IGN today, that I realised this. Microsoft tried to excite gamers with new technology and features and hoped we would forget about the looming questions many of us had before the reveal. We did haven't, though. Is the console going to be always online? We still don't have a clear answer. Can it play used games? Microsoft have said yes, but many have a feeling there is a fine print associated with the answer. Hopefully we will get the answers to those questions soon, but maybe there was a reason why Microsoft chose not to address them in their reveal? Maybe they don't want to lie, but don't want to tell us what we don't want to hear?
Overall, I think the Xbox One reveal was entertaining. There were some low points and some things dragged on for a bit too long, but we now have an idea of what the Xbox One will be like. Some people are going to like it, and some are going to hate it, but we can't change what Microsoft is trying to do. In the end, the Xbox One is going to play games, no one can deny that. Microsoft have definitely taken a bold move by turning their video game console into an "All-In-One Home Entertainment System," but it will be nothing new to current Xbox 360 owners. Love it or hate it, the Xbox One is coming and I am interested to see what happens at E3 and over the next few years.
Nathan Manning is an Editor for AnalogAddiction, where you can find some awesome reviews, news and features. You can find him on Twitter and you can find AnalogAddiction there as well.


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Fops and Dandies
Fops And Dandies Shoutout: Razzle Dazzle
When our network partner, Fops And Dandies, put together an outfit in homage of Elton John, we thought to expand on the idea with a little razzle dazzle of our own. Luckily, we're long past the days where young women wear sparkly tank tops and 'wet curls' in honor of a night on the town. That doesn't mean, however, a little sparkle is impossible to conjure. Indeed, New York City can bring out the drag queen in all of us and as a general rule, no matter how wacked you think you look when you step out the door, we guarantee someone else will have taken it a step further. Below, our spread of some summertime gems that would look great layered with different textures and colors, for a wild and crazy, dare we say it, 'boho luxe' look. Opulence, afterall, is a trend bound for Fall 08, so consider it a wise investment, if nothing else.
Click for more Shoutouts


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They Were Collaborators #230
Alfred Hitchcock and Evan Hunter (aka, Ed McBain).
This was posted by Richard Gibson
|your thoughts:
The series is: They Were Collaborators
3 comments:
- Vanwall said...
Two wonderful storytellers. Nice pic!
- November 15, 2006 4:39 PM
- swac said...
Ditto! I've never seen this shot before.
- November 16, 2006 11:48 AM
- Richard Gibson said...
I deeply regret hearing Evan Hunter talk about the time his book came out 'Hitch and Me' and for some cash strapped reason not being able to afford the measly four quid to buy the damn book and get him to sign it.
- November 16, 2006 5:14 PM
Subscribe to: Post Comments (Atom)


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Apps That Think in Ink
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With Form Designer ($500), it's possible to create digital versions of forms that you normally have to fill out by hand. These can be made from scratch with built-in tools, or created by cleaning up scanned-in versions of paper forms. While initial form building can take some time, subsequent data entry using Form Filler ($200) is fast, thanks to custom input fields. For example, a phone number line would only expect integers and wouldn't mistake a 1 for a lowercase l.
Active Ink Forms Designer from Active Ink Software


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Business Law
Ask a Business Lawyer. Get Business Law Questions Answered ASAP.
If you have member managers then the member managers get listed but you would not be listed if you were just a member. As long as you are not a manager you will not have to be listed in the annual report either.
This communication is not intended as legal advice. A local attorney should always be consulted for legal advice. No client/attorney relationship is intended or created by this communication.
You will not be able to be a member manager without the disclosure. Consequently, you will have to provide minority interests to whoever are to be the member managers. The disclosure of the member managers is not optional. You will not be able to manage the company day to day and not be disclosed as a member manager.
If you do not manage you are not the responsible party. Consequently, that does not become an issue. That is what the member managers do. If you are involved in management you have to be disclosed as such. If you just invest and have management in the hands of others you do not appear in any reports. If you are involved in management you will have to be listed. The managers would be president and the other officers otherwise it is clear that they are not all the managers.


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Dysfunctional executive behavior: What can organizations do?
Much has been made of dysfunctional executive behavior in recent years. As such, the purpose of this article is to assist organizations in the design of executive work. To better construct a work environment that diminishes self-serving and unethical behavior, we propose that organizations structure an executive's work around three factors: the accountability environment, managerial discretion, and relationship composition. These factors are used to describe how organizations can better design executives' work so as to promote more desirable executive behavior. We describe how these factors should be calibrated, as well as how they affect each other.
If you experience problems downloading a file, check if you have the proper application to view it first. In case of further problems read the IDEAS help page. Note that these files are not on the IDEAS site. Please be patient as the files may be large.
As the access to this document is restricted, you may want to look for a different version under "Related research" (further below) or search for a different version of it.
Volume (Year): 53 (2010)
Issue (Month): 6 (November)
Pages: 581-590
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| Web page: http://www.elsevier.com/locate/bushor
References listed on IDEAS
Please report citation or reference errors to , or , if you are the registered author of the cited work, log in to your RePEc Author Service profile, click on "citations" and make appropriate adjustments.:
- Fama, Eugene F & Jensen, Michael C, 1983. "Separation of Ownership and Control," Journal of Law and Economics, University of Chicago Press, vol. 26(2), pages 301-325, June.
- Vafeas, Nikos, 1999. "Board meeting frequency and firm performance," Journal of Financial Economics, Elsevier, vol. 53(1), pages 113-142, July.
- Hall, Angela T. & Bowen, Michael G. & Ferris, Gerald R. & Royle, M. Todd & Fitzgibbons, Dale E., 2007. "The accountability lens: A new way to view management issues," Business Horizons, Elsevier, vol. 50(5), pages 405-413.
- Perryman, Alexa A. & Butler, Frank C. & Martin, John A. & Ferris, Gerald R., 2010. "When the CEO is ill: Keeping quiet or going public?," Business Horizons, Elsevier, vol. 53(1), pages 21-29, January.
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Takayoshi Kido aka Kido Koin (1833-1877) is my favorite protagonist from the Bakumatsu Period of Japanese history when the Tokugawa regime came crashing down after over 250 years in power, to be replaced by the modernizing and westernizing though extremely conservative Meiji government of 1868.
I got to know Kido through his excellent diaries, which recall a by-gone life of late Edo Period Japan. Kido relates a typical day leisurely sailing down the river from Kyoto to Osaka, enjoying sake all the way, spending the evening flirting with geisha in Sakai, before taking a Western ship to Edo - all in the midst of a violent revolution! What calmness under pressure! What elan!
Kido was the son of a Choshu clan doctor but was adopted by the Katsura family when he was seven years old and was called Katsura Kogoro at this time. As a youth, Kido was a student of Yoshida Shoin in Hagi.
Kido's early life in both Edo and Kyoto was eventful and full of political intrigue and danger as he conspired with Choshu activists in the struggle against the Tokugawa. While in hiding from the feared Shinsengumi swordsmen in Kyoto, Kido sought refuge in a geisha house and was later to marry one of the geisha working there.
Kido also supervised the construction of Choshu's first Western-style ship in Hagi in his role of advisor to the Choshu daimyo.
After the Restoration in 1868, Kido was instrumental in drafting the Five Charter Oath and the legislation that would lead to the abolition of the han (domain) system and the subsequent beginnings of a centralized government. Kido was also part of the Iwakura Mission that toured the USA and Europe in 1871 to study the political and economic institutions of the west.
Kido's residence is preserved in Hagi's Horiuchi quarter and is a simple Japanese-style house with tatami floors in lots of small rooms. There are two entrances: one for family members and the other for guests.
Kido died early after a long illness, possibly TB and beri-beri, exacerbated by the prodigious amounts of sake he seems to have drunk throughout his life.
"I drank more than I should have tonight, and I dreamed endlessly. At times the moon shone brightly, then again it was hidden behind a cloud. My two acquaintances have died, so I do not record their names; but I grieve for them."
Excerpt from Kido's diary August 6, 1868
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Happy Birthday, Michelle Obama!
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When Michelle Obama became the latest First Lady of the United States in 2008, she immediately gained the fashion community's vote for her all-American style. In honor of her 49th birthday, we take a look back at her most stylish moments.
More from ELLE:


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About the Book
This book contains some of the stories that have affected me deeply during the first two years of my life on the road in primarily Asia. Asia Stories features my essays and visual stories from Papua New Guinea, Laos and Cambodia.
I am fascinated by how we live so differently on this planet, and yet share many of the same needs and dreams. It is important to me that you connect with the lives of the people and places through more than just the images; I would like you to experience their stories, and feel the gap narrow between your life and theirs.
The images and text have been carefully sequenced, curated, edited and are displayed on beautiful Mohawk fine art uncoated paper. The book is 138 pages hardcover, 25x20 cm.
Photographs and text by Flemming Bo Jensen. Edited by Charlene Winfred.
Features & Details
- Category Arts & Photography
Standard Landscape, 10×8 in, 25×20 cm
138 Pages
- Publish Date Aug 26, 2011
- Language English
- Tags papua new guinea, fine art, asia, laos, cambodia, photography, portraits, ethno, east, travel
About the Creator
I am currently a global gypsy and can be found, literally, anywhere on earth. I was the former head of IT in an agency in the Danish Government, but unable to shed the long held dream of growing up to be Luke Skywalker, I left Copenhagen and my job in 2009, and took off around the world living on the road as a gypsy, photographer, time-traveler, jedi. I am currently working on a wide ranging photography project of documenting my own experience as a global gypsy. Photography is my primary form of creative expression, as it allows me to fuse my own perspective (imaginary or otherwise) with the real world as I experience it, within the frame of a moment. I am also an aspiring filmmaker and write about my ongoing gypsy journey on my blog. I am an official Fuji X- Photographer and primarily photographs with the Fuji X-Pro1 camera.
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1 Comments
Bob Bowden Beautiful shots here - you can tell you have a great way with people. I liked your approach too ...... stories & photos - nice. I'm preparing my own attempt, from a different perspective ..... I'm certainly envious that you make a living from this!


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NetWellness is a global, community service providing quality, unbiased health information from our partner university faculty. NetWellness is commercial-free and does not accept advertising.
Wednesday, August 23, 2017
Pharmacy and Medications
Steroid and Weight Gain
During the last three months i have had three cortisone injections. My last was approximently three weeks ago. I have gained 25 pounds. I am not expected to recieve any more injections. Will this weight come back off? I do have a lot of water retention and have not had a period since the first shot.
Cortisone belongs to a class of drugs known as glucocorticoids or, more commonly, "steroids." In the body, cortisone mimics the action of a hormone called cortisol, which plays an important role in regulating metabolism.When someone is exposed to high levels of glucocorticoids for extended periods of time, he or she can develop a condition called Cushing's syndrome. Although the presentation varies, menstrual irregularities, water retention, and weight gain are some of the more common aspects along with high blood sugar, high blood pressure, and osteoporosis. For the most part, the effects of Cushing's syndrome caused by medications tend to resolve within 6-12 months of stopping therapy.
The weight gain associated with Cushing's syndrome can be caused by water retention, but it is not uncommon for people to develop fat deposits around the abdomen and upper trunk. Did you notice that being on cortisone increased your appetite? This is a common side effect of glucocorticoids and may, in fact, be the culprit behind your weight gain.The only sure way to get rid of this weight is to stick to a sensible diet and exercise regularly. Of course, check with your physician before beginning any diet or exercise program.
Submitted by:
Laura Lanning
PharmD candidate 2011
The Ohio State University
College of Pharmacy
Carmen M Hadley, RPh, CSPI
Former Clinical Instructor
College of Pharmacy
The Ohio State University


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When I first set up this twitter page almost 2 years ago, I did not expect to make friends who had the same emotional connection (some may call it an emotional addiction...... :P ) as me, to this one show. I first thought that there was something wrong with me because i was becoming WAY to attached to the characters....... but when I entered the world of twitter and met all of you, fellow, crazy people you almost made me feel sane again. Thank you all for including me in this family we have created. A (virtual) family which will never be broken. Who knew this time last year One Tree Hill would still be at such an important place in our hearts. Lets hope it will be the same next year.
Thanks again to all of you, and just remember that "Tree Hill Is Our Home."
@OTHfamily x


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Yes this sounds stupid! But I've given my boyfriend a lot of bjs before and last night, "when he started coming" I swallowed at least 9 times and each time I had a mouth full of stuff and then he was still coming more. And I didn't have enough time to swallow anymore if just kept coming. It sort of tasted like his cum but at the same time it didn't and there was just sooo much more of it. Was it really just cum or could it be anything else.
Most Helpful Guy
I doubt it was pee. Yes, that does sound like a lot, but some guys have that occasionally after not ejaculating for a while. There's also the fact that there is a little valve that is automatically closed at the ureter (tube taking pee from the bladder to the urethra and then out) when a guy gets an erection. It can take ages for a guy to be able to pee, even after ejaculating, because of that. When he really needs to go, that can be quite painful.11|00|0
As per the update, I can't think how that's possible. I do know that sometimes blowing a load can also feel a little like peeing, but that's rare. I seriously can't think how it's biologically possible to pee with an erection. That valve closes the bladder off - it shouldn't allow any urine through once he's hard.


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Completion of the longer format of these courses(marked* in the prices) enables you to consolidate your Cruising and Day Skipper certificates into a single live-aboard sail.
As a professional sail training organization, our aim is to equip you to sail safely and competently at your desired level of proficiency. Our training, which has been developed over more than 10 years, teaches you to sail rather than to simply crew. In keeping with most recognized educational theories, we introduce the concepts of sailing as a whole then broaden them and go into more depth.
Learn to sail on a keelboat and some special cruising techniques course. This course includes the ASA Keelboat (101) Certificate.
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