text:
Summary: Organic Anion Transporter Polypeptide (OATP) family
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Organic anion-transporting polypeptide Edit Wikipedia article
|Organic Anion Transporter Polypeptide (OATP) family
An organic anion-transporting polypeptide (OATP) is a membrane transport protein or 'transporter' that mediates the transport of mainly organic anions across the cell membrane. Therefore, OATPs are present in the lipid bilayer of the cell membrane, acting as the cell's gatekeepers. OATPs belong to the Solute Carrier Family (SLC), more specifically the Solute Carrier Organic Anion (SLCO) gene subfamily [1]
Organic anion transporting polypeptides carry bile acids as well as bilirubin and numerous hormones such as thyroid and steroid hormones across the basolateral membrane (facing sinusoids) in hepatocytes, for excretion in bile.[2] As well as expression in the liver, OATPs are expressed in many other tissues on basolateral and apical membranes, transporting anions, as well as neutral and even cationic compounds. They also transport an extremely diverse range of drug compounds, ranging from anti-cancer, antibiotic, lipid lowering to anti-diabetic drugs, as well as toxins and poisons.
Various anti-cancer drugs like pazopanib, vandetanib, nilotinib, canertinib and erlotinib are known to be transported via OATPs (OATP-1B1 and OATP-1B3).[3]
Also, anti-cancer drugs specially the tyrosine kinase inhibitors have been reported as inhibitors of OATP (OATP-1B1 and OATP-1B3. Pazopanib and Nilotinib have shown their inhibitory potential only towards OATP-1B1 but not towards OATP-1B3 whereas Vandetanib has shown its inhibitory activity only towards OATP-1B3 but not towards OATP-1B1[4]).
They also transport the dye bromosulphopthalein, availing it as a liver-testing substance.[2]
The table below shows the 11 known human OATPs. Note: Human OATPs are designated with capital letters, animal Oatps are designated with lower class letters. The 'SLCO' stands for their gene name; 'solute carrier organic anion.' Previous nomenclature using letters and numbers (e.g. OATP-A, OATP-8 is no longer correct. The most well characterised human OATPs are OATP1A2, OATP1B1, OATP1B3 and OATP2B1. Very little is known about the function and characteristics of OATP5A1 and OATP6A1.
|Protein Name
|Solute carrier organic anion transporter family member 1A2
|Solute carrier organic anion transporter family member 1B1
|Solute carrier organic anion transporter family member 1B3
|Solute carrier organic anion transporter family member 1C1
|Brain, testis
|Solute carrier organic anion transporter family member 2A1
|Solute carrier organic anion transporter family member 2B1
|Solute carrier organic anion transporter family member 3A1
|Testis, brain, heart, lung, spleen
|Solute carrier organic anion transporter family member 4A1
|Heart, placenta, lung, liver
|Solute carrier organic anion transporter family member 4C1
|Solute carrier organic anion transporter family member 5A1
|Breast, fetal brain, prostate
|Solute carrier organic anion transporter family member 6A1
|Testes, spleen, brain, placenta
The OATPs play a role in the transport of some classes of drugs across the cell membrane, particularly in the liver and kidney. In the liver, OATPs are expressed on the basolateral membrane of hepatocytes, transporting compounds into the hepatocyte for biotransformation. A number of drug-drug interactions have been associated with the OATPs, affecting the pharmacokinetics and pharmacodynamics of drugs. This is most commonly where one drug inhibits the transport of another drug into the hepatocyte, so that it is retained longer in the body (i.e. increased plasma half-life). The OATPs most associated with these interactions are OATP1B1, OATP1B3 and OATP2B1, which are all present on the hepatocyte basolateral (sinusoidal) membrane. OATP1B1 and OATP1B3 are known to play an important role in hepatic drug disposition. These OATPs contribute towards first step of hepatic accumulation and can influence the disposition of drug via hepatic route.[3] The most clinically relevant interactions have been associated with the lipid lowering drugs statins, which led to the removal of cerivastatin from the market in 2002. Single nucleotide polymorphisms (SNPs) are also associated with the OATPs; particularly OATP1B1.
Many modulators of OATP function have been identified based on in vitro research in OATP-transfected cell lines.[5][6] Both OATP activation and inhibition has been observed and an in silico model for structure-based identification of OATP modulation was developed.[7]
Since tyrosine kinase inhibitors (TKIs) are metabolized in the liver, interaction of TKIs with OATP1B1 and OATP1B3 can be considered as important molecular targets for transporter mediated drug-drug interactions.[3]
Along with the organic anion transporters, organic cation transporters and the ATP-binding cassette transporters, the OATPs play an important role in the absorption, distribution, metabolism and exretion (ADME) of many drugs.
OATPs are present in many animals, including fruit flies, zebrafish, dogs, cows, rats, mice, monkeys and horses. OATPs are not present in bacteria, indicating their evolution from the animal kingdom. However homologs do not correlate well with the human OATPs and therefore it is likely that isoforms arose by gene duplication. OATPs have however been found in insects,[8] suggesting that their evolution was early in the formation of the animal kingdom.
- ^ Hagenbuch B, Meier PJ (February 2004). "Organic anion transporting polypeptides of the OATP/ SLC21 family: phylogenetic classification as OATP/ SLCO superfamily, new nomenclature and molecular/functional properties". Pflugers Arch. 447 (5): 653–65. doi:10.1007/s00424-003-1168-y. PMID 14579113.
- ^ a b Pages 980-990 in:Walter F. Boron (2003). Medical Physiology: A Cellular And Molecular Approaoch. Elsevier/Saunders. p. 1300. ISBN 1-4160-2328-3.
- ^ a b c Khurana V, Minocha M, Pal D, Mitra AK (March 2014). "Role of OATP-1B1 and/or OATP-1B3 in hepatic disposition of tyrosine kinase inhibitors.". Drug Metabol Drug Interact. 0 (3): 1–11. doi:10.1515/dmdi-2013-0062. PMID 24643910.
- ^ Khurana V, Minocha M, Pal D, Mitra AK (May 2014). "Inhibition of OATP-1B1 and OATP-1B3 by tyrosine kinase inhibitors.". Drug Metabol Drug Interact. 0 (4): 1–11. doi:10.1515/dmdi-2014-0014. PMID 24807167.
- ^ Annaert P, Ye ZW, Stieger B, Augustijns P. Interaction of HIV protease inhibitors with OATP1B1, 1B3, and 2B1" Xenobiotica 2010 Mar;40(3):163-76. doi: 10.3109/00498250903509375. PMID 20102298.
- ^ De Bruyn, T; Fattah, S; Stieger, B; Augustijns, P; Annaert, P (Nov 2011). "Sodium fluorescein is a probe substrate for hepatic drug transport mediated by OATP1B1 and OATP1B3". J Pharm Sci. 100 (11): 5018–30. doi:10.1002/jps.22694. PMID 21837650.
- ^ De Bruyn, T; van Westen, GJ; Ijzerman, AP; Stieger, B; de Witte, P; Augustijns, PF; Annaert, PP (Jun 2013). "Structure-based identification of OATP1B1/3 inhibitors". Mol Pharmacol. 83 (6): 1257–67. doi:10.1124/mol.112.084152. PMID 23571415.
- ^ Torrie LS, Radford JC, Southall TD, Kean L, Dinsmore AJ, Davies SA, Dow JA (2004-09-07). "Resolution of the insect ouabain paradox". PNAS. 101 (37): 13689–93. doi:10.1073/pnas.0403087101. PMC 518814 . PMID 15347816.
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Organic Anion Transporter Polypeptide (OATP) family Provide feedback
This family consists of several eukaryotic Organic-Anion-Transporting Polypeptides (OATPs). Several have been identified mostly in human and rat. Different OATPs vary in tissue distribution and substrate specificity. Since the numbering of different OATPs in particular species was based originally on the order of discovery, similarly numbered OATPs in humans and rats did not necessarily correspond in function, tissue distribution and substrate specificity (in spite of the name, some OATPs also transport organic cations and neutral molecules). Thus, Tamai et al. [1] initiated the current scheme of using digits for rat OATPs and letters for human ones. Prostaglandin transporter (PGT) proteins (e.g. Q92959) are also considered to be OATP family members. In addition, the methotrexate transporter OATK (P70502) is closely related to OATPs. This family also includes several predicted proteins from Caenorhabditis elegans and Drosophila melanogaster. This similarity was not previously noted. Note: Members of this family are described (in the Swiss-Prot database) as belonging to the SLC21 family of transporters.
Literature references
Tamai I, Nezu J, Uchino H, Sai Y, Oku A, Shimane M, Tsuji A; , Biochem Biophys Res Commun 2000;273:251-260.: Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family. PUBMED:10873595 EPMC:10873595
Internal database links
|Kazal_1 Kazal_2 LacY_symp MFS_1 MFS_1_like MFS_2 MFS_3 MFS_4 MFS_5 PTR2 PUCC Sugar_tr TRI12
|Similarity to PfamA using HHSearch:
|Sugar_tr MFS_1
External database links
|Transporter classification:
This tab holds annotation information from the InterPro database.
InterPro entry IPR004156
This family consists of several eukaryotic Organic-Anion-Transporting Polypeptides (OATPs). Several have been identified mostly in human and rat. Different OATPs vary in tissue distribution and substrate specificity. Since the numbering of different OATPs in particular species was based originally on the order of discovery, similarly numbered OATPs in humans and rats did not necessarily correspond in function, tissue distribution and substrate specificity (in spite of the name, some OATPs also transport organic cations and neutral molecules) so a scheme of using digits for rat OATPs and letters for human ones was introduced [PUBMED:10873595]. Prostaglandin transporter (PGT) proteins are also considered to be OATP family members. In addition, the methotrexate transporter OATK is closely related to OATPs. This family also includes several predicted proteins from Caenorhabditis elegans and Drosophila melanogaster. This similarity was not previously noted. Note: Members of this family are described (in the UniProtKB/Swiss-Prot database) as belonging to the SLC21 family of transporters.
Gene Ontology
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
|Cellular component
|membrane (GO:0016020)
|Molecular function
|transporter activity (GO:0005215)
|Biological process
|transport (GO:0006810)
Domain organisation
Below is a listing of the unique domain organisations or architectures in which this domain is found. More...
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Pfam Clan
This family is a member of clan MFS (CL0015), which has the following description:
The major facilitator superfamily (MFS) is one of the two largest families of membrane transporters found on Earth [1]. It is present ubiquitously in bacteria, archaea, and eukarya and includes members that can function by solute uniport, solute/cation symport, solute/cation antiport and/or solute/solute antiport with inwardly and/or outwardly directed polarity [1]. All permeases of the MFS possess either 12 or 14 transmembrane helices [1].
The clan contains the following 24 members:Acatn ATG22 BT1 Folate_carrier FPN1 FTR1 LacY_symp MFS_1 MFS_1_like MFS_2 MFS_3 MFS_4 MFS_5 MFS_Mycoplasma Nodulin-like Nuc_H_symport Nucleoside_tran OATP PTR2 PUCC Sugar_tr TLC TRI12 UNC-93
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|Representative proteomes
1Cannot generate PP/Heatmap alignments for seeds; no PP data available
Key: available, not generated, — not available.
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|Seed source:
|Pfam-B_626 (release 6.5)
|Previous IDs:
|Mifsud W, Bateman A
|Number in seed:
|Number in full:
|Average length of the domain:
|432.80 aa
|Average identity of full alignment:
|25 %
|Average coverage of the sequence by the domain:
|79.59 %
HMM information
|HMM build commands:
build method: hmmbuild -o /dev/null --hand HMM SEED
search method: hmmsearch -Z 26740544 -E 1000 --cpu 4 HMM pfamseq
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Species distribution
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Unmapped species names
The tree is built by looking at each sequence in the full alignment for the family. We take the name of the species given by UniProt and try to map that to the full taxonomic tree from NCBI. In some cases, the name chosen by UniProt does not map to any node in the NCBI tree, perhaps because the chosen name is listed as a synonym or a misspelling in the NCBI taxonomy.
So that these nodes are not simply omitted from the sunburst tree, we group them together in a separate branch (or segment of the sunburst tree). Since we cannot determine the lineage for these unmapped species, we show all levels between the superkingdom and the species as "uncategorised".
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Interactive tree
For all of the domain matches in a full alignment, we count the number that are found on all sequences in the alignment. This total is shown in the purple box.
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We use the NCBI species tree to group organisms according to their taxonomy and this forms the structure of the displayed tree. Note that in some cases the trees are too large (have too many nodes) to allow us to build an interactive tree, but in most cases you can still view the tree in a plain text, non-interactive representation. Those species which are represented in the seed alignment for this domain are highlighted.
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There is 1 interaction for this family. More...
We determine these interactions using iPfam, which considers the interactions between residues in three-dimensional protein structures and maps those interactions back to Pfam families. You can find more information about the iPfam algorithm in the journal article that accompanies the website.
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the OATP domain has been found. There are 1 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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GLANDORF — Senior citizens in the St. George
Deanery had some "Fun in the Sun" Sunday night during the Senior
Citizen Prom.
The annual event was held at the
Glandorf St. John's parish hall. The Hawaiian theme meal included
teriyaki chicken breast, potatoes, vegetables and assorted pies.
The annual event was hosted by high
school youth in the St. George Deanery. In addition to the meal the
evening included games, a performance by "Out of the Blue"
Ottawa-Glandorf show choir, a skit, and crowning of the king and
queen and awarding of door prizes.
Ruth Drerup from Glandorf St. John
parish was crowned as the queen. Fr. Tony Fortman C.PP.S. was crowned
as the king.
Read more about this and see more
pictures in this week's Putnam County Sentinel.
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Information published on this site is not for republication in print or web media without the expressed written consent of Putnam Sentinel Media.


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OK, so we can all probably agree that the worst thing at the Oscars wasn't on the red carpet — it was Seth MacFarlane's tone-deaf jokes about Quvenzhane Wallis and other celebs that fell flat. Well, maybe you did like him, or even Jennifer Lawrence winning for the godawful Silver Linings Playbook.
Well, whatever you thought of the ceremony, here's what our fashionista, J. Denton Bricker, thought of the best and worst ladies' wear of the evening. Feel free to disagree or add your own.
Amy Adams — The shape of her pale blue Oscar de la Renta was dazzling with every shot from the front row.
Jessica Chastain — The shimmering Art Deco design (also from Armani Prive) conjured images of Old Hollywood, including Marilyn.
Naomi Watts — This sharp silver number from Armani Prive looked like nothing else on the red carpet and seemed to catch color.
Reese Witherspoon — The form-fitting cobalt gown by Louis Vuitton was sleek and classic with a little edge. Her vintage locks were the best of the evening.
Sandra Bullock — Elegant, effortless and breathtaking in Ellie Saab, who wouldn't want to receive an award from her?
Melissa McCarthy — The effort was there, but the grey blob of a dress from David Meister just didn't work.
Anne Hathaway — The pale pink Prada fit Anne awkwardly and accentuated her breasts in all the wrong, pointed ways.
Helena Bonham Carter — Known for her eccentric tastes, the spooky Vivienne Westwood was just wrong for the Oscar red carpet.


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There will be one more player vying for the fifth outfielder position on the Mets roster during Spring Training.
The Mets picked up utility outfielder Jason Pridie today from the Minnesota Twins, who had placed him on waivers.
Pridie appeared in just 11 games over two seasons with his former team. He had one walk, one strikeout and three runs in four at-bats. It's not exactly a large sample size, but he did hit nine home runs and had 25 stolen bases in 121 games with Triple-A Rochester last season.


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'Batman Returns'
April 19, 2014 | 11:58 a.m.
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The 103rd Recruit Class of the Baltimore County Fire-Rescue Academy will graduate tonight, June 25, at 7 p.m. The ceremony will be held at Loch Raven High School, 1212 Cowpens Avenue, Towson, MD 21286.
Deputy Administrative Officer Donna Morrison, representing County Executive Kevin Kamenetz, and Fire Chief John Hohman will address the class and award the diplomas.
The graduating class comprises 36 recruits – 14 women and 22 men – who have trained as emergency medical technicians and paramedics. They will serve as paramedics and probationary emergency medical technicians in the EMS division for two years.
The recruits began training March 24 at the Fire-Rescue Academy in Sparrows Point and have completed 18 weeks of training. Their instruction includes: emergency vehicle operation, hazardous materials, basic firefighting skills, self-contained breathing apparatus, EMT skills, Fire Department operations, CPR, intravenous therapy, safety and various topics related to basic and advanced medical care.


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Contributor: Andrew Mazibrada, From: AndrewMazibrada.com
The unforgiving, belligerent rain makes each and every rock greasy. Finding something safe on which to place my feet or hands is proving impossible.
Contributor: Andrew Mazibrada, From: AndrewMazibrada.com
This article is a short resume of the general principles involved in planning a long distance trek which can be defined more specifically as a multi-day journey of some considerable length. All this article is intended to do is to provide a springboard to more detailed research as the planning is more involved than a trip which lasts a few days.
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Thanks for mainitaining this forum, it's been (and will continue to be) a great python tutor for me.
I have a small class (only one function so far) of dialogs for opening the files and selecting starting directories that I need for my application. I am using the tkinter fieldialog library and python3.3 on fedora 20. The class works exactly as I want it to, except for one thing. I don't know how to make the main TK window invisable, and I don't know how to gracefully destroy it (main window) when when I finish with the dialog window.
Here's the code:
- Code: Select all
import tkinter
import tkinter.filedialog
import time;
class fileDialogs():
def openLog():
"""Opens selected Logfile."""
ticks = time.time()
logFileName = ('log' + str( int(ticks) ) + '.log')
file_opt = options = {}
options['title'] = 'Open Log File'
options['initialdir'] = '.'
options['initialfile'] = (logFileName)
options['defaultextension'] = '.log'
options['filetypes'] = [('log files', '.log'),
('all files', '.*'),
('text files', '.txt')]
return tkinter.filedialog.asksaveasfilename(**file_opt)
logName = ''
logName = fileDialogs.openLog()
print( 'Logname: ', logName )
As soon as I fix these two issues, I'll add other code that I require. I'd appreciate your thoughts on this. I'm thinking there must be some sort of 'not visible' attribute, and a destroy method as well.


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Did you know?It's advisable, in the interests of safety, to never snorkel alone. Always go with a reliable 'snorkel buddy' so you have someone to assist you should either of you get into trouble.
Where you choose to snorkel in South Africa is dependent on your fondness for warm water, fear of predatory sharks and what you're hoping to see.
The activity is cheap, requiring nothing more than a mask, snorkel and fins, all sold inexpensively at sports outlets and general dealers.
Bathed by the warm Agulhas current, the tropical waters of KwaZulu-Natal offer an abundance of shallow reefs – the most southerly coral reefs on the planet – shipwrecks, manta rays, dolphins and a colourful variety of invertebrates. The best snorkelling sites are located north off Sodwana Bay, where excellent visibility and well over 1 000 fish species are the main attraction.
The sponge and coral-coated Aliwal Shoal off Umkomaas is a 40-minute drive south of Durban and home to tiger sharks, ragged-tooth sharks, turtles, many fish and interesting reef structure. Several kilometers off Shelly Beach, south of Port Shepstone, lie the Protea Banks, home to hammerhead, ragged-tooth and tiger sharks and many shallow reefs.
In the Eastern Cape, the pretty Garden Route beckons snorkellers to the Knysna lagoon to see its rare endemic seahorses, and to Mossel Bay, Storms River and Plettenberg Bay, where scattered reefs and shipwrecks attract interesting marine life.
If cold water is no deterrent, Cape Town's wafting kelp beds are home to some interesting and ancient fish species. Add the attraction of shipwrecks, seals, penguins, sharks and whales to get an idea of what you're likely to experience in Atlantic waters.
Travel tips & Planning info
Who to contact
Local tourism authorities in the coastal provinces will be able to advise you on the places best suited to snorkelling. Visit their websites for contact details.
Best time to visit
Temperatures are warmer during summer, but water clarity is best in winter.
Tours to do
Once the snorkelling bug has bitten you might discover an urge to go shark-cage diving or scuba diving. Diving courses are offered at larger coastal towns and cities, particularly in Durban and Cape Town.
What to pack
A UV-resistant rash vest for sun protection and a wetsuit in colder waters is advisable.
Where to stay
The more popular coastal cities like Durban, Port Elizabeth, East London and Cape Town are geared up for tourists, with plenty of holiday accommodation available, from back packers hostels to top-flight hotels.


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Italian Culture on Our Screen with the San Diego Italian Film Festival
MOPA has always been a premiere Southern California locale to interact with photography's past and present, but you may forget that the Museum is also a wonderful venue to experience diverse and rarely screened films from around the world. A huge opportunity to see cinema at its finest just kicked off this past weekend with the San Diego Italian Film Festival and we want to remind you to come to MOPA and see the moving pictures we have on display.
Now in its fifth year at MOPA, the San Diego Italian Film Festival has grown into an amazing conduit to enjoy Italian culture. From October 29th through November 12th, the festival features 15 spectacular movies that evoke laughter, tears, and passion. To open the festival, a retrospective of three pinnacle films that helped establish the Italian Neorealism genre, were screened. All shown on 35mm, two of these gorgeous films were U.S. premieres and are unlikely to be shown in San Diego again.
If you missed that opportunity, don't worry the festival continues with a variety of great movies to choose from. See director Paolo Virzi's award winning 2010 film La prima cosa bella (The first beautiful thing), enjoy a witty romantic comedy like Generazione mille euro (The 1000-euro Generation) or take an Italian thriller with La doppia ora (The Double Hour). Each screening begins at 7:00pm and is always well attended, so make sure you arrive early. Every movie is free except the closing film, Diciotto anni dopo (Eighteen years later), which is part of the festival's Gala. An evening with Italian music and cinema, enchanting food, fine wine and kind-hearted company that is well worth the ticket price.
To find out more about the festival and the films, visit: www.sandiegoitalinfilmfestival.com


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FN Dish on Dishesby FN Dish Editor in View All Posts, November 14th, 2008
One of the best kept secrets in NY is tucked beneath Food Network. In an undisclosed location (think: the warehouse in Indiana Jones), lies a vast storeroom of the dishes, props and accessories FN has used for the past 15 years. Rachael Ray's original GBs, Mario Batali's favorite ravioli rolling pin, Sunny's entire kitchen — it's there.
One artistic visionary, FN set decorator Wendy and her creative prop coordinator, Jamie, have the awesome responsibility of maintaining, organizing, expanding and decorating with the massive collection.
FN Dish will start showcasing certain pieces, like this giant bowl that's great for "kicking light" — (being highly reflective on set). Wendy stumbled across it and knew it would be perfect for a dramatic Iron Chef America ingredient.
Questions about a Food Network set? Need inspiration for an innovative tablescape? Curious about culinary "minis"? Post and Wendy will attend to the most burning questions…


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10. Re: New Razr Maxx startup advicechipjonz Apr 4, 2012 11:19 AM (in response to B33)
Well, it looks like my plans had to change because I did in fact run into this problem. I went to one Verizon store and called two others and was told that most stores in the area are sold out of the Razr Maxx, so I had to order the phone. It is supposed to be overnighted to me, and I should be receiving it through FedEx tomorrow. I am actually kind of disappointed about this, not because I don't have the phone in my hands right now, but because Verizon knew that this may be a problem two weeks ago when I was in the store and they never suggested that I order the phone early so that I could have the phone on my upgrade date. I think this is poor customer service, and if they really cared about their customers they would have acknowledged that problem, put aside their egos, and let me order the phone early so that by the time the backorder was done it would be April 4th and I would have my phone!
11. Re: New Razr Maxx startup adviceB33 Apr 4, 2012 12:59 PM (in response to chipjonz)
Yup that's what i thought would happen an when you get your (Box Cookies just joking a little!) remember to read my post or if have already Dismounting the Sim is easy if you have a X-Acto knife with a No.11 blade you just pierce the tabs with light pressure an then you lift the holder up away from it. Then grab the Sim Card by it's Edges an with the Gold side Up an the Flap Door down insert the Sim in your Maxx an if you don't have a Sim tool to push the Sim all the way into the Maxx you can make one.
Get some Round tooth picks at your Local Grocery an take the Tooth Pick an Cut it with a Razr Blade or your X-acto Knife to wear it has a flat Blunt Face on both ends then you can use it as a Sim Card Push tool this helps to the Fully insert the Sim all the way into the Razr. You will fill it Lock as has a Spring Mechanism to keep the Card from falling out of the Phone. Other than Just Have Fun with it B33
12. Re: New Razr Maxx startup advicechipjonz Apr 4, 2012 6:42 PM (in response to B33)
I had to reschedule the Android: Getting Started workshop, and I rescheduled it for tomorrow, so hopefully I will have my phone in time to attend the workshop--otherwise, I will have to reschedule it again. I think I will just take the phone and the SIM card right over to Verizon for the workshop and have them install the SIM card. Thanks for the SIM card installation instructions!
13. Re: New Razr Maxx startup adviceB33 Apr 4, 2012 7:04 PM (in response to chipjonz)
Good Deal: Just make sure when the Rep installs the Card He or she Does not touch the Gold area of the Card when it's Taken out of the Holder.. And have fun at the Class..
FedEx Deliveries Usually for Residential is in the Afternoon: My Maxx Arrived Around 3pm the Day i got it..
14. Re: New Razr Maxx startup advicechipjonz Apr 5, 2012 7:45 AM (in response to B33)
I just talked to FedEx because I can't get any tracking information on the phone: They told me the phone is out on the van for delivery and should be delivered sometime before 3, but could be delivered earlier. We got a delivery yesterday from FedEx and it came between 12-1, so I'm hopeful my phone will come around that time also. The workshop I scheduled is from 3:30-5, so I would rather not have to take the phone right off the porch and get in the car to go to the workshop.
15. Re: New Razr Maxx startup adviceB33 Apr 5, 2012 10:14 AM (in response to chipjonz)
The amazing Capabilities of this phone is Endless i an watching the Masters Golf Tournament write now an it is Amazing the Video playback on the Maxx Far exceed any thing i have ever had previous in my phones. An phones out there right Now when you Maxx Download this App Masters from the Play store then watch the live Video an see how Good it is.
Just to let you Know i am watching this With my Wi-Fi to get the Very best Video Play back. 4G might do the same.. 3G is not to good at it.. B33
16. Re: New Razr Maxx startup adviceCody21 Apr 5, 2012 10:26 AM (in response to B33)
Watching it on 4G -- incredible !! Gets some intermittent artifacts / pixelation - but all in all, very good. Thanks for the info B33 !
17. Re: New Razr Maxx startup adviceB33 Apr 5, 2012 10:50 AM (in response to Cody21)
Cody i am actually watching it Via my Wi-Fi. Sorry i didn't say that in my Post but Cody i am so excited right now i can hardly keep my Emotions Down & type this out i want jump up n down this is so Incredible..
18. Re: New Razr Maxx startup advicechipjonz Apr 5, 2012 11:08 AM (in response to B33)
B33, it's a little after 2 here in my area (southeastern PA) and I still don't have my phone yet. I have been very anxiously waiting for my phone all day, and at this point I'm feeling like my phone will probably get here right at 3 or maybe later since I have been waiting for it all day. I hope the phone gets here in time for me to go to the workshop, but if it doesn't I'll reschedule the workshop for another day and then just spend the time setting the phone up, maybe go to the Verizon store anyway and have them transfer everything over from my old phone to the new one.
19. Re: New Razr Maxx startup adviceB33 Apr 5, 2012 11:21 AM (in response to chipjonz)
Yea i know what your going threw you wait you wait you here a truck not the right one then wait an want to pull your here an then you read post like mine an that makes it even worse to wait. but it will get there to ya.. an when it Does Calm Down an open the box real slowly take out each piece one at a time an read threw it carefully. An if you don't make it to that Class hey don't worry about it. Costumer service can Walk you threw the Programming it. if needs be!


text:
Molas Collection on Display at Gallery
Hattiesburg, Miss., October 9, 2012 - The Lucile Parker Gallery at William Carey University will display "From Eden to Eternity: Interpretations of Bible Stories in Reversed Embroidery from the Molas Collection of Sandra and Bob Bowden," a collection of folk art in fiber from the San Blas Islands, Oct. 2-26.
A reception for the exhibit will be held Oct. 11 from 5 until 6 p.m. at the gallery. Dr. Garry Breland, vice president for academic affairs, will present a brief gallery talk at 5:30 p.m.
The exhibit features 40 stunning molas, the signature textile craft of the Cuna Indian women of the San Blas Islands, an archipelago of more than 300 islands on Panama's northern coast. Developed to provide elaborate front and back fabric panels for the traditional blouse worn by the women, the technique involves a process of reverse appliqué which combines layers of brightly colored fabrics stitched together and then cut into intricate patterns, exposing colors from underlying layers. The top layer is typically treated with both direct appliqué and embroidery to create an even richer surface.
Animals and marine life are common motifs for the molas, as are geometric and mythological patterns. A good quality mola panel may take a month or more to make and requires 40 or more hours of work. The molas in the exhibit feature whimsical interpretations of biblical stories and symbols. Every piece reflects a love of color and overall design. The exhibit has been previously featured at prestigious locations such as Yale University.
For more information or to arrange a special hours or a group tour, call 601-318-6192. The Lucile Parker Gallery is open 1-4 p.m. during the week except during university holidays and the summer.


text:
Here's the latest from Jesus Chairez:
MÉXICO CITY — I went to my first lesbian wedding ever last month … and it happened here in México City. The women getting married weren't Mexican, or even Latina, but gringas. The very gay wedding of Cristina Potters and Judith McKnight (center) was held in their charming apartment in México City's chic neighborhood Col. Condesa on July 22.
What struck me as fascinating was the guest list. Those who came to see included México City's first lesbian couple to marry, Lol Kin Castañeda Badillo (left) and Judith Vázquez Arreola (right), who wed when México City's same-sex marriage law took effect on March 4, 2010.
So I wondered: How do two retired, mature, easy-going, non-political American ladies living in México City meet two of México's A-list lesbian activists?


text:
Now, first of all, and most importantly, Standard is a constructed fictional priori constructed language. I realise I may seem to have repeated myself; but there is a reason for this, because while being a constructed language in reality, it is also a constructed language in its internal history.
Standard was created to ease communication between 4 different sapient species. And while it remained close to its logical principles for a good while, it has eventually been subdued to natural evolution of languages, and have spawned countless dialects across Explored Space. But Standard (or in Standard: Kemp-haremle) is generally still considered an universal language; far greater than any previous lingua franca.
Standard's grammar is as simple as it gets; a position in a clause indicates 'word type' (e.g. noun, verb, etc.) and as such a clause can at maximum be constructed of 5 words ('subclauses' are considered just that; subclasses, and thus will appear in replacement of a word); clause definer, subject, object, verb and pre/postposition.
The only oddity in that list may be 'clause definer', but it's actually quite simple; this word defines if the clause has a special use; e.g. being a question or a reasoning. It also defines the relationship between the previous clause, e.g. 'but' in English and so on. The pronoun 'ai' is used to refer to just that and can be used as the subject or object (or any word, actually, not sure how much sense that would make), referring to the previous clause's subject.
Example: Luki amnuki nuk i, le ammunuki ai?
Or in English: If the future is now, is the past then the future?
Or more lit.: If[clause definer] the-future now is, question[clause definer] the-un-future [previous clause's subject; the-future]?
As you will notice, 'am-' is a noun definitive prefix, but not presented here is the plural suffix, which is -'za.
Writing system
Standard's writing system is an alphabet. Plain and simple. It consist of 24 letters; 16 consonants and 8 vowels. And these 24 letters represents only 24 sounds.
- a /ɑ/
- e /e/
- i /i/
- o /o/
- u /u/
- y /y/
- æ /ɛ/
- ó /ɔ/
- d /?/
- f /f/
- h /h/
- j /j/
- k /k/
- l /l/
- m /m/
- n /n/
- p /p/
- r /ɹ/
- s /s/
- t /t/
- v /v/
- w /w/
- z /z/
- š /ʃ/
As you will notice, each glyph has an 'opposite'. While the writing system should always be read from a certain perspective, it never requires to be read 'left to right', even if that is the most common usage of it. There are some glyphs to indicate direction, but these are generally considered to be 'non-Standard', and thus vary from place to place.
The usage of the opposite characters are used in the numeral systems, as you will notice; there are 24 characters, and thus 12 pairs. The writing system uses the same glyphs for numerals, a number for each pair, which means you can pick two glyphs per numeral. To indicate something is numerals and not letters, a line hovering the characters are used.
Another thing about the glyphs; they are very simple, and don't look all that pretty up there, but handwriting looks slightly different (I shall make some handwriting of a poem I wrote in the language at a later point).
As said, the language is a priori language, and as such, includes no origin in any other existing language. If there are similarities, these are purely coincidences. The vocabulary is far from finished, however, I am still working on it.
But if you want to, I have created a wiki as a dictionary, where you can read what I have written (unfortunately, I do not intend to grant anyone besides myself the access to edit pages). A warning first; this language is intended for a novel I am writing, the dictionary may provide spoilers for the novel, but if you are fine by that (and so far there aren't actually any spoilers), you can visit it here.
In closing, I welcome any questions regarding the language.


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The Grant County Public Library could see tax revenue slashed depending on the outcome of a legal ruling against libraries in Kenton and Campbell counties.
Lawsuits were filed against the public libraries in Kenton and Campbell counties earlier this year claiming that the libraries have been using the wrong law to raise taxes since 1979.
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So, I was just watching pre2.0 cutscenes and i was wonder, if FFXIV didnt do a very good job before.. were they planning to add more storyline or increase the level cap?
Do they plan to add a permanent end to the MMORPG when 2.0 is released and not add more level caps and such? was just curious.