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The Physical Chemistry of Sickle Cell Anemia
Peter G. Vekilov, Professor of Chemical and Biomolecular Engineering and Chemistry, University of Houston, Texas
Friday, October 31, 2008, 3:30pm
Spanos Auditorium
Quicktime Large (137 MB)
Quicktime Small (102 MB)
This seminar is part of the Jones Seminars on Science, Technology, and Society series
Sickle cell anemia is a debilitating genetic disease, which affects hundreds of thousands of babies born each year worldwide. Its primary pathogenic event is the formation of long fibers (with 14 molecules in the cross section) of a mutant, sickle cell, hemoglobin (HbS). Fiber formation is a first order phase transition, and, thus, sickle cell anemia is one of a line of diseases (Alzheimer's, Huntington's, prion, etc.) in which nucleation initiates pathophysiology. We show that the fiber growth follows a first-order, Kramers-type kinetics model. The value of the entropy of the transition state for incorporation into a fiber suggests that this entropy is due to the release of the last layer of water molecules structured around contact sites on the surface of the HbS molecules. As a result of this entropy gain, the free-energy barrier for incorporation of HbS molecules into a fiber is negligible and fiber growth unprecedentedly fast. We also show that the homogeneous nucleation of HbS polymers follows a two-step mechanism with metastable dense liquid clusters serving as precursor to the ordered nuclei of the HbS polymer. The presence of a precursor in the HbS nucleation mechanism allows low-concentration solution components to strongly affect the nucleation kinetics. We show that free heme, excessively released in sickle erythrocytes due to autooxidation, leads to orders of magnitude faster nucleation and that its removal prevents polymerization. These findings suggest that variations of the concentrations of the components of the red cell cytosol, e.g., heme, in patients might account for the high variability of the disease in genetically identical patients. In addition, these components can potentially be utilized for control of HbS polymerization and treatment of the disease.
- J. Mol. Biol. 365, 425 (2007)
- Biophys. J. 92, 902 (2007)
- Biophys. J. 92, 267 (2007)
- Brit. J. Haematol. 139, 173 (2007)
- J. Mol. Biol. 377, 882 (2008)
About the Speaker
Peter G. Vekilov received his Ph.D. in 1991 from the Russian Academy of Sciences, Institute of Crystallography, under advice from A.A. Chernov. After postdoctoral stints in Sofia, Bulgaria, Tsukuba, Japan, and Huntsville, Alabama, he was an Assistant Professor of Chemistry at the University in Alabama in Huntsville. Since 2001, he has been an Associate Professor and, since 2007, Professor of Chemical and Biomolecular Engineering and of Chemistry at the University of Houston. His main research interests are in the area of phase transitions in protein solutions. He has studied their thermodynamic aspects, including intermolecular interactions and phase diagrams and has demonstrated the existence of mesoscopic metastable phases. Nucleation kinetics and mechanisms have been a major focus of study, and a two-step mechanism, involving a metastable dense liquid precursor has been put forth. Molecular mechanisms of crystallization of protein and other materials form solution have been elucidated, highlighting the role of water structuring for the determination of the rate of the process. He is the recipient of the 2006 UH Excellence in Research and Scholarship Award, 2002 DuPont Research Award, 2001 UAH Foundation Research and Creative Achievement Award, 1995 International Union of Crystallography Young Scientist Award, among others. He is a member of the US National Committee for Crystallography, the executive councils of the International Organization for Biological Crystallization and the American Association for Crystal Growth, he has organized and chaired numerous conferences and symposia and served as a chair of the 2007 Gordon Conference on Thin Film and Crystal Growth Mechanisms.


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Centura Health has more experts in more places throughout the region. Start your health journey by finding the right one for you.
ENGLEWOOD, COLO. - (May 22, 2014) - Centura Health, the region's health care leader, in conjunction with its Affiliate Hospitals, today announced it received a $257,000 grant for telecommunications equipment from the U.S. Department of Agriculture (USDA) Distance Learning and Telemedicine Loan and Grant Program (DLT). This grant further supports development of shared programs between Centura Health and its Affiliate Hospitals to expand access to clinical services in Colorado's rural communities for delivery of high-value care.
The DLT grant will fund one telemedicine mobile exam cart equipped with high definition video conferencing and built-in medical devices, including a digital stethoscope, at each of Centura Health's Colorado Affiliate Hospitals as well as Mercy Regional Medical Center in Durango, Colo. It also funds 16 secure video conferencing units for Colorado Health Neighborhoods' specialty providers to deliver clinical care to patients through the mobile exam carts. These two telecommunications technologies work together to bring specialists to patients locally. Colorado has not received a DLT grant since 2010 and the grant awarded to Centura Health further supports efforts to remove barriers to care and promotes access to high-quality, evidence-based health care services, keeping health care local and nurturing the health of communities across the region.
DLT provides grants to entities delivering education, training and health care resources in rural areas. Grant recipients must prove there is an economic need and provide at least 15 percent in matching funds. Centura Health, in conjunction with its Affiliate Hospitals, will supplement the grant with $78,000 in matching funds.In August 2013, the DLT program received 185 eligible grant applications and approximately 25 percent met the scoring criteria to receive funds.
The grant Centura Health received is designated to support rural health care in Colorado. While Centura Health has eight Affiliate Hospitals in Colorado and western Kansas, only its Colorado Affiliates are eligible to receive equipment through this grant. These hospitals include:
Centura Health and its Affiliate Hospitals believe health care should be delivered locally whenever possible. Keeping health care local contributes to a community's livability and economic viability and is a critical consideration for the rural provider.
By collaborating long-term to provide specific resources and services that support development of shared programs, Centura Health and its Affiliate Hospitals are working to expand existing clinical services and specialties delivered in rural communities to improve the value of health care.QUOTE:
"Meeting the health care needs of rural America is critical to ensuring every individual has access to high-value care when and where it is needed," said Samantha Lippolis, telehealth manager, Centura Health. "We are excited to have the USDA recognize the health care needs of residents living in Colorado's rural communities and support our efforts to optimize health care value, ultimately leading to improved health outcomes, increased service and convenience, and lower health care costs." # # #About Centura Health
Centura Health connects individuals, families and neighborhoods across Colorado and western Kansas with more than 6,000 physicians and 17,100 of the best hearts and minds in health care. Through our 15 hospitals, six senior living communities, health neighborhoods, physician practices and clinics, home care and hospice services, and Flight For Life® Colorado, we are making the region's best health care accessible and affordable in every community we serve. We believe you can inspire the people you care about to live healthier lives by encouraging them to do the little things that can make a big difference. We're Centura Health, and we're here for your health. For information about Centura Health or any of the facilities in our network, please visit www.centura.org. Contact:Jennifer WillsCentura firstname.lastname@example.com: 303-804-8222
Call us today if you need help selecting a health care provider or to speak to one of our knowledgeable experts about staying well or assessing symptoms.
Our search tools require a zip code to match the location nearest you.

subset: commoncrawl


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AppRadio (SPH-DA01)
A Revolutionary Way to Use Apps in the Car
- Control compatible apps from the convenience of the industry's first capacitive, multi-touch display
- Designed to grow with iOS and an expanding library of compatible apps
- Compatible with iPhone® 4 and iPod Touch® 4th Gen
Suggested Price: $399.99
NOTE: Do not use your Pioneer system if doing so will divert your attention in any way from the safe operation of your vehicle. Always observe safe driving rules and driving laws. In some states certain operations of devices while driving may be illegal. Where such regulations apply, they must be obeyed.
1Review instruction manual for safe operation of AppRadio. Do not use any feature of this product if it cannot be operated safely while driving. Prior to operating iPhone apps that are accessible from this unit, review all usage instructions, cautions, and warning messages that are provided by the App developer. When using navigation apps, stay alert and observe real world conditions first.
2Netflix and Hulu+ are paid subscription services not affiliated with Pioneer, and are not included. Visit www.netflix.com and www.hulu.com/plus for more information.
3Bluetooth functionality requires a compatible Bluetooth-enabled mobile phone. Certain Bluetooth features may not be supported by all compatible Bluetooth-enabled devices, and/or the functionality of such features may be limited in certain devices or by certain wireless carriers.
PIONEER and AppRadio are trademarks or registered trademarks of Pioneer Corporation.
Apple is a trademark of Apple Inc., registered in the U.S. and other countries.
IPOD, IPOD TOUCH, IPHONE, IPAD and iTUNES are trademarks of Apple Inc., registered in the U.S. and other jurisdictions.
GOOGLE and YouTube are registered trademarks of Google Inc.
DashCommand is a trademark of Palmer Performance Engineering, Inc.
StreamS HiFi is a trademark of Modulation Index, LLC.
AUPEO! Personal Radio is a trademark of AUPEO!
MotionX is a trademark of Fullpower-MotionX in the United States and other countries.
INRIX is a registered trademark of Inrix, Inc.
RDIO is a registered trademark of Rdio, Inc.
Pandora is a registered trademark of Pandora Media, Inc.
Netflix® is a registered trademark of Netflix, Inc.
Hulu and Hulu+ are registered trademarks of Hulu LLC.
BLUETOOTH is a registered trademark of Bluetooth SIG, Inc.


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Surf Lessons are popping us overnight.
No regulation down at Kahalu'u Beach Park.

Looks like any joe shmoe with some boards can pick up some newbees ask for cash and jump in the line up!

Hawaii Lifegaurd Surf Instructors has been in Kona since 1994- we are established Lifeguards and Certified Instructors and are finding it harder and harder to keep up with all these back yard low ballers!

What are we to do? We are doing all we can to run a ligitamate business and no one is regulating illegal uncertified pretend surf companies. DLNR says they are too busy and short staffed to deal with surf schools?????

Hu?


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Hautlence watches
Stunning good looks and outstanding and unique mechanics-- joined together with the finest materials-- mark Hautlence watches as some of the finest available. The HL line is comprised of a series of limited and numbered editions with only 88 pieces per model. The HLs series is waterproof to 50 meters. Prices range around 35.000 euros (ca. $55,000) and up.


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Navy extends public comment for Sonar testing
NORTH COAST- The U.S. Navy has extended the period for public comment on training and testing that will be conducted off the North Coast. The timeframe has been extended to April 15th.
The Navy plans to conduct tests and training of the Pacific Northwest that uses sonar and explosives.
Public input is for Northwest Training and Testing (NWTT) Draft Environmental Impact Statement/Overseas Environmental Impact Statement (EIS/OEIS). The Navy has held eight information meetings up and down the coast.
Comment can be submitted by mail or online at the following:
Or by mail:
Naval Facilities Engineering Command Northwest
Attention: Ms. Kimberly Kler – NWTT EIS/OEIS Project Manager
1101 Tautog Circle, Suite 203
Silverdale, WA 98315-1101


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PUBLIC Health England (PHE) are warning people to take care in the sunshine as temperatures rise.
People spending more than 20 minutes outdoors in the sun are advised to apply sunscreen of at least SPF15 with UVA protection, wear UV sunglasses to reduce UV exposure to the eyes, walk in the shade, and wear a hat.
Also, people should wear light, loose-fitting cotton clothes which will minimise the risk of sunburn, drink lots of cool drinks, avoid alcohol, seek shade and look out for others – especially the vulnerable such as older people, young children, babies and those with serious illnesses.
Officials are also reminding people not to leave anyone in a closed, parked vehicle, especially infants, young children or animals.
Dr Mark Evans, deputy director of Health Protection for the Avon, Gloucestershire and Wiltshire PHE Centre, said: "It's good that the sun is shining and we can all enjoy a taste of summer – but it's important to remember that rising heat does bring health risks for some.
"For the time being we recommend that people keep an eye on the weather forecast for the coming days, consider avoiding the sun between 11am and 3pm, drink plenty of fluids and keep an eye out for the vulnerable, children and older people."
For more information on sun safety, visit http://sunsmart.org.uk/UV-the-sun-and-skin-cancer/ how-to-enjoy-the-sun-safely.


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POMONA - Ranch Hills Elementary School is collecting staple food this week to be donated to Inland Valley Hope Partners.
Organizers are inviting residents of the neighborhood surrounding the school and other Pomona residents to take part in the effort.
The school is collecting canned tuna, peanut butter in plastic jars, macaroni and cheese, rice, and beans.
The rice and beans can be either canned or dry, organizers said.
The items can be dropped off at the school office between 8 a.m. and 4 p.m. until Friday.
Ranch Hills Elementary is at 2 Trabuco Place in the Phillips Ranch community.
All of the items will go to Inland Valley Hope Partners, which provides food to needy families and individuals through its food pantry.
Reach Monica via email, follow her on Twitter @PomonaNow, or call her at 909-483-9336.


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Dustin Red L/S Shirt
Item: 1310300-072
Our Dustin fit button down in iridescent red. Features a contemporary pocket square button tab detailing. Made from 100% cotton, this shirt's details include front welt pocket with triangular flap and box pleat at back yoke.
Customer Reviews
Fabric content: 100% Cotton
Care instructions: Machine wash cold, gentle cycle with like colors, tumble dry low, and warm iron if needed.


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With three race wins and one All Star victory in the last four weeks, Hendrick Motorsports' Teams are all smiles except one - former champion Jeff Gordon is struggling.
Jimmie Johnson's victory at the Monster Mile in Dover last Sunday gave him two wins at the halfway mark of NASCAR's regular season. Add a convincing victory in the All Star event along the way and suddenly the talk of a sixth Cup Series Championship begins to surface.
Although Johnson doesn't want to talk about it, many are picking his No. 48 team as the one to beat for the 2012 title.
"I think things are very good for our company," Johnson said after the event. "We know the areas where we found some raw speed and now we are fine-tuning from here. I think two wins puts us in a very nice position. We need to keep the pressure on and roll into September with the same thing in order to win a championship."
With two teams already in the win column, the focus is to get the other two to follow suit. The No. 88 team of Dale Earnhardt Jr. seems poised to move forward. His 11 Top 10 finishes in the first 13 races are more than any other driver and his is the only team to complete all competitive laps so far this season.
With the consistency question out of the way, the only thing standing between Junior and victory is closing the deal.
The No. 24 team of four-time champion Jeff Gordon faces the biggest challenge if team owner Rick Hendrick wants to get all his teams into the Chase. To say that Gordon has been bitten by the bad luck bug would be an understatement.
Sitting in 21st position in the point standings at the season's halfway mark, Gordon finds himself in jeopardy of not making the Top 10 by the postseason. His best chance to make the Chase is to start winning.
"We don't care about finishing Top 15 or Top 10 right now. That does nothing for us," Gordon said. "We need wins."
Gordon has run well this season but has been the victim of some very bad luck in virtually every race. For a time last Sunday, it appeared that Gordon was close to changing his fortune.
"The fastest car doesn't always win the race," Gordon said. "It's always more frustrating when you've got a car that can win and show it by going up there and taking the lead."
Gordon overcame his first bad break, a loose wheel on lap 250, which put him a lap down. However, when climbing back through the field after his last pit stop, a caution came out for a questionable piece of debris that put the former champion a lap down for the second time.
The unfortunate events seemed to seal his fate for another afternoon and didn't sit well with the frustrated driver.
"Yeah, I can't wait to see that debris on TV," Gordon said. "I'd like to see it, because I certainly never saw it. I'm not going to make any comments until I see what their reasoning for it was."
There isn't much you can do about changing a team's luck, but if Gordon is to make the Chase, he will have to start winning races. The No. 24 team has had speed and cars that have been capable of winning. The only thing they need is to overcome the bad luck and they will be Chase bound.
You can rest assured that the Hendrick organization will be working hard to help him do just that.
Copyright 2012 Raycom News Network. All rights reserved.


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Dirk Kempthorne
News about Dirk Kempthorne, including commentary and archival articles published in The New York Times.
Finger-Pointing on Oil Shifts to Bush Era
Democrats argue that the Interior Department was "off duty for nearly a decade" in regulating offshore oil drilling.
July 20, 2010, Tuesday
MORE ON DIRK KEMPTHORNE AND: Gulf of Mexico Oil Spill (2010) , Norton, Gale , Kempthorne, Dirk , Interior Department , News , Gulf of Mexico
Rule Eases a Mandate Under a Law on Wildlife
The Interior Department announced a rule that has largely freed federal agencies from consulting independent biologists before projects that might harm federally protected wildlife.
December 12, 2008, Friday
MORE ON DIRK KEMPTHORNE AND: Interior Department , Endangered and Extinct Species , Kempthorne, Dirk , Global Warming , Environment
Pact Would Open River, Removing Four Dams
The agreement, which would open more than 300 miles of the Klamath River, provides a formal framework to defuse deeply emotional arguments that have echoed through the Northwest.
November 14, 2008, Friday
MORE ON DIRK KEMPTHORNE AND: Hydroelectric Power , PacifiCorp , Interior Department , Kempthorne, Dirk , Oregon , California , Levees and Dams , Rivers , Salmon , Water , Irrigation , Environment , Agriculture , Fishing, Commercial
Last-Minute Mischief
All presidents indulge in end-of-the-term environmental rule-making. President Clinton's rules were mostly good. Not surprisingly, most of President Bush's proposals are not.
October 18, 2008, Saturday
MORE ON DIRK KEMPTHORNE AND: Bush, George W , Conservation of Resources , Offshore Exploration and Installations , Environment , Bureau of Land Management , Fish and Wildlife Service , Audubon Society, National , Interior Department , Kempthorne, Dirk
Interior Secretary Says He May Fire Gift-Takers
Interior Secretary Dirk Kempthorne told a House committee that he might fire employees involved in ethics abuses at the agency, which collects oil and gas royalties.
September 19, 2008, Friday
MORE ON DIRK KEMPTHORNE AND: Interior Department , Ethics , Kempthorne, Dirk , Oil (Petroleum) and Gasoline , Devaney, Earl E , Minerals Management Service
Interior's Proposed Rules
To the Editor:.
August 19, 2008, Tuesday
MORE ON DIRK KEMPTHORNE AND: Endangered and Extinct Species , Kempthorne, Dirk , Law and Legislation , Interior Department
An Endangered Act
Interior Secretary Dirk Kempthorne's latest assault on the Endangered Species Act deserves to be struck down.
August 13, 2008, Wednesday
MORE ON DIRK KEMPTHORNE AND: Endangered and Extinct Species , Law and Legislation , Kempthorne, Dirk , Interior Department , Environment , Environmental Protection Agency , Bush, George W , Editorials
Alaska: Suit Filed Over Polar Bears
The state has sued Interior Secretary Dirk Kempthorne, seeking to reverse his decision to give polar bears protection under the Endangered Species Act.
August 6, 2008, Wednesday
MORE ON DIRK KEMPTHORNE AND: Kempthorne, Dirk , Polar Bears , Alaska
Torrent in Colorado River Is Unleashed to Aid Fish
A torrent of water was released into the Colorado River from the Glen Canyon Dam in Arizona, in a disputed effort to improve the environment for fish in the Grand Canyon.
March 6, 2008, Thursday
MORE ON DIRK KEMPTHORNE AND: Grand Canyon (Ariz) , Fish and Other Marine Life , Rivers , Dams and Dikes , National Parks, Monuments and Seashores , Kempthorne, Dirk , Parks and Other Recreation Areas
Save the Polar Bear
To the Editor:.
January 19, 2008, Saturday
MORE ON DIRK KEMPTHORNE AND: Polar Bears , Interior Department , Bears , Endangered and Extinct Species , United States Politics and Government , Environment , World Wildlife Fund , Kempthorne, Dirk
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CUMBRIA Police have today (Sunday Feb 9) named the victim of a fatal road traffic collision yesterday.
The woman who died was Margaret Bold, 76, from Mansion Gardens, Egremont.
She had been driving a Ford Ka at 9.36am yesterday on the A595 at Bigrigg.
Also in the car was an 86 year old woman from Egremont, who was taken to the Royal Victoria Infirmary at Newcastle by air ambulance.
She remains in a critical but stable condition.
The other vehicle involved was a Peugeot 508, driven by a 40-year-old man from Whitehaven.
Police said he has been taken to West Cumberland Hospital to be checked over.
The road was re-opened at 1.45pm after collision investigation officers examined the area.
Anyone with information or who witnessed the collision is asked to contact Police on 101.


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Internet Explorer 7 has been retired from BrowserLab
Today we have pushed a minor new version of BrowserLab that no longer contains Internet Explorer 7. If you still need to test for IE7 in BrowserLab, you can do this using IE8 and a by adding bit of code to your page(s). To learn more about IE8's Compatibility Mode, you can read about it in these Microsoft Blogs:
Introducing Compatibility View
Understanding Compatibility Modes in Internet Explorer 8
Remember to remove that code once your testing is complete, unless you want your IE8 visitors to see your page as they would in IE7.
Bruce Bowman
Adobe BrowserLab product manager
twitter: @brucebowman


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Jeff B wrote:I find it helps. It cleans the edge up of any residual burrs if nothing else. I strop after stones but I don't get crazy with it either. 1u on felt and/or just bare leather.
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