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Sox see five-game winning streak end in slugfest
Papi notches four RBIs, but Tazawa squanders seventh-inning lead
TORONTO -- The Red Sox clawed and battled all game after playing the majority of Tuesday night's contest from behind.
And once Boston finally gained its first lead of the game and silenced a crowd of 22,195 in the seventh, it was quickly relinquished in the bottom half of the frame and the team never recovered.
Junichi Tazawa surrendered a two-run homer to Edwin Encarnacion in the seventh inning, resulting in the pivotal blow in the Red Sox's 9-7 loss to the Blue Jays in the first of a three-game set at Rogers Centre.
"One mislocated pitch," manager John Farrell said about Tazawa's location. "It just didn't stay to the spot down and away, and Edwin put a good swing on it.
"Edwin's a very good hitter. Obviously he has been very productive here the last couple years."
With two outs and none on, Tazawa walked Jose Bautista before Encarnacion blasted the two-run shot to center field for his second homer of the game, putting Toronto ahead, 8-7. Encarnacion also hit a two-run shot into the 500 level in left field in the fifth inning off starter Jon Lester.
It wasn't Lester's strongest performance, and he said he felt bad that Tazawa was credited with the loss when it was the lefty who put the Red Sox in a hole. The two earned runs Tazawa surrendered on the Encarnacion homer marked the first time he has allowed more than one earned run in a game since Sept. 4, 2009, a span of 53 games.
"That's a tough spot and I'll take Tazawa 10 out of 10 times in that matchup," said Lester, whose six runs allowed (five earned) were his most since surrendering 11 to the Blue Jays last July. "That's a tough one for Taz. Those are the ones you wish you could flip flop with him, but next time he'll pick me up. I'm not worried about it."
Tazawa entered the seventh with a 7-6 lead thanks in large part to David Ortiz, who has been on an absolute tear to start his season.
After the Blue Jays botched a double-play ball that would have potentially ended the frame, Dustin Pedroia walked to load the bases for Ortiz, who cleared them with a three-run double to right. Ortiz drilled a 3-1 fastball off reliever Steve Delabar to put Boston in front, 7-6.
Ortiz also hit a solo homer, his third of the year, in the fourth inning to put the Red Sox on the board. Ortiz is batting .500 with a whopping .917 slugging percentage and 15 RBIs over just nine games this season.
"He continues to, not only just step into our offense, but come up big in many situations," Farrell said. "He has just done an outstanding job for us."
The designated hitter was one of three Red Sox to go deep in the contest.
Mike Carp hit his first home run two batters after Ortiz went deep in the fourth off Blue Jays starter Brandon Morrow, and Jonny Gomes hit a pinch-hit homer, also his first with Boston, in the sixth inning.
Boston's offense bailed out Lester, who struggled for the second consecutive start, from taking the loss.
Lester surrendered a run in the first and three more in the third after a bizarre play led to a pair of Toronto runs.
The left-hander allowed the first three runners of the inning to reach base by giving up a leadoff single, hitting Rajai Davis with a pitch and then walking Bautista on four straight pitches. Things really unraveled after that.
With Encarnacion at the plate, catcher Jarrod Saltalamacchia attempted to pick off Bautista at first base, but he threw the ball wide of the bag and into right field, which allowed two runs to score and put the Blue Jays in front, 3-0.
It was revealed postgame that Saltalamacchia hit home-plate umpire Clint Fagan on the throw, which is the reason the ball sailed into the outfield.
"I went to go throw it and my elbow hit the umpire's mask," Saltalamacchia said.
Since Saltalamacchia made contact with the umpire, it should have been a dead ball. However, he didn't know the ruling on the play and it's something he has done before.
Saltalamacchia talked with Fagan after the frame, but Fagan said that he hit him on the follow through, not when he cocked back to throw, which the backstop disputes.
"It's kind of impossible," Saltalamacchia said.
Even with the bases loaded and Saltalamacchia throwing behind the runners, Farrell said it was absolutely the right play based on the catcher's usual accuracy and how much Bautista was off the bag. The throw was supposed to be to the inside part of the base.
Lester had to battle all game and used 100 pitches to get through his six innings of work. He allowed six hits while walking two and striking out five. This came after issuing a season-high six walks in his last start against Oakland. The southpaw said he didn't feel right from the beginning of the game and wasn't throwing any pitches with the polish that he should have been.
Farrell thought Lester had trouble finishing his cutter, which left the pitch a little flat in the zone. The mammoth homer Encarnacion hit out was off a cutter.
"It felt very good, but I never thought it was going to go that far, but I hit the ball good," Encarnacion said.
Morrow wasn't sharp either, lasting just five innings while allowing three runs on six hits. He came out gunning, punching out five consecutive at one point, before the Red Sox got to him in the fourth.
Despite the loss, which snapped Boston's five-game winning streak and prevented the team from setting a club record for wins in April, the Red Sox ended the month with the best record in baseball for the 11th time in franchise history.
Chris Toman is a contributor to MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.


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H pylori is a common bacteria. It is a cause of ulcers (sores). H pylori weakens the mucous layer that coats the inside of the stomach and duodenum (first part of the small intestine). This allows stomach acid to flow through the weakened layer and burn the tissue of the stomach wall below.
Ulcer symptoms can come and go. Or, your child may not have symptoms at all. Common symptoms include:
Burning, cramping, or hungerlike pain in your child's stomach area. This often happens 1–3 hours after a meal, or in the middle of the night.
Pain that gets better or worse with eating.
Nausea or vomiting (blood may be present in vomit).
Black, tarry stools (this means the ulcer is bleeding).
Your child's health care provider can order tests to see if ulcers are present. The health care provider will then check to see if the ulcers are caused by H pylori. Tests may include:
A special x-ray called a barium upper gastrointestinal (GI) series. Your child will drink a chalky liquid that helps ulcers show up on an x-ray.
An endoscopic exam. An endoscope is a thin, soft tube with a tiny camera attached. After your child is sedated or under anesthesia, the tube is inserted through your child's mouth into the stomach. This allows the doctor to see the ulcers. This tube may also be used to do a biopsy (take a tiny tissue sample).
Blood, stool, or breath tests to check for H pylori in your child's digestive tract.
Ulcers caused by H pylori are fairly easy to treat. The health care provider will prescribe antibiotics to kill H pylori bacteria. Your child may also need ulcer medications to help the stomach lining heal. Follow all instructions carefully about giving your child medications. This will often prevent ulcers caused by H pylori from returning.

subset: commoncrawl


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Hey there, time traveller!
This article was published 22/8/2011 (2189 days ago), so information in it may no longer be current.
If Canada's chief electoral officer has his way, voters in at least one riding in Canada will be the first to get to vote online in the not-too-distant future.
Marc Mayrand issued his required post-election report last week and said while the operations of the May 2 federal election went off relatively smoothly, if Canada is to start getting more people to vote we have to get out of the Dark Ages.
Basically, we can shop, order take-out, buy and sell stocks, communicate with people in outer space and even raise virtual children online.
But we can't vote.
Mayrand is seeking approval from the House of Commons to run an e-voting pilot project in a byelection sometime after 2013.
If it works, it will slowly be extended to general elections. Does it mean Canadians will be able to vote online in the next federal election in 2015? Doubtful, but at least it's a start.
Although the May 2 federal election had better turnout than 2008, it was still a paltry 61 per cent. More than 9.4 million Canadians still didn't make it to the polls.
Graphs of voter turnout show a sharp decline in the last three decades. It's to the point where political parties actually have entire strategies built around targeting voters who tend to show up more -- seniors, new Canadians and the wealthy, while the more marginalized and younger Canadians get left out in the cold.
Why people don't vote is not really complex.
Some simply don't care. Others don't think it matters. But in repeated surveys, the No. 1 reason people tend to give for not voting is they were either too busy or it was too inconvenient.
Mayrand acknowledges that fact, noting in 2011 Canadians want "services that are available wherever they happen to be, when they want the services and on their own terms."
Without quite saying it, Mayrand is basically acknowledging something Canadians should probably admit.
We're all used to our entitlements and believe we should always be able to do what we want, when we want do it. Voting is no different.
But Elections Canada can't do anything more about it on its own.
For the past decade, it's bent over backwards to try to make it easier for people to vote. More advanced polls in more locations, easier identification requirements for some voters, more accessible polling stations and as many advertisements as possible during a writ period to tell people how and when to vote.
In the last election, the agency even managed to help Manitoba flood evacuees with special polls set up in their Winnipeg hotels.
But they've reached the end of the rope afforded them by Parliament. Any further changes need Parliament's approval -- including the more complex idea of e-voting or simpler changes such as setting up special polls in shopping malls where anyone from any riding can vote.
A recommendation for the latter was made by Elections Canada seven years ago, after the 2004 election. The House of Commons agreed it was a good idea. But minority governments that were distracted with incessant politicking and were constantly interrupted by elections and proroguing just never got their acts together to do anything about it.
Most Canadians know voting is something they should do. (Many who don't are embarrassed enough to lie about it, hence surveys about why people vote always suggest far more people vote than actually do.)
The Free Press is engaged in a project for this fall's provincial election with a simple goal -- to get more people to vote. We can and will do what we can to improve the process, elevate the debate and help people understand what is going on. But nothing anyone can say or do will likely have as much impact on voter turnout as being able to point and click your way to doing your civic duty.
E-voting may be expensive in the short term to develop. Making it as secure as can be to protect the process is critical. Nobody wants to find out a bunch of potted plants got registered to cast ballots or that Auntie Fanny who died six years ago somehow rose from her grave to mark her ballot.
We spent $291 million to have our election May 2 -- that's $12 for every registered voter. It's not chump change, but democracy is certainly worth the price tag. But it's certain the money would be even more well spent if every registered voter actually voted.


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Parents and community members soon may have increased access to information about the Grant County School District.
The Grant County School Board recently approved the first year of a five-year plan to have a district-sponsored cable channel with on-demand Internet capabilities.
The goal of the technology is to provide another outlet to distribute information about school events and news through video clips, photos, calendars and other methods.
If you currently subscribe or have subscribed in the past to the Grant County News, then simply find your account number on your mailing label and enter it below.
Click the question mark below to see where your account ID appears on your mailing label.
If you are new to the award winning Grant County News and wish to get a subscription or simply gain access to our online content then please enter your ZIP code below and continue to setup your account.
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Self defense experts said the type of energy a person gives off when they are walking in public, down a street or in a parking lot can help determine whether they become a target for crime.
Being distracted by a phone call or reading a text or email on a smart phone or looking down could make someone more susceptible to crime.
Self defense trainers at Innergetics Peace Center in Eastpointe said people need to fight off a would-be attacker with their mind first.
"If you're confident in yourself, they're working their plans and they're looking around and seeing who's really not paying attention, lets see who I can intimidate and you walk out with confidence. What's the first thing that comes to their mind? 'Hmm ... she might give me a problem,'" said Roy Barnett, who works at Innergetics Peace Center.
Barnett has trained in martial arts since he was 12. He said self defense begins with the energy you give off to others.
Students at Innergetics said they like learning the connection between the mind and body when it comes to self defense.
"Most classes just show you the physical part of what you need to do. they don't tell you how to be prepared, how to, you know, walk confidently, how to use, you know your outward energy to say to prevent yourself from that.," said Amiee Gaekle. If you look and feel confident than others will be like, won't bother you."
"Remembering that the power of mind and knowing that to avoid the situation in the first place is the most important part," said Samantha Spencer.
The center focuses on mental emotional martial arts which is using your body and mind together to fight off an attacker.
"Anyone can be a victim anytime of any crime and knowing what to do when it happens to you is the most important thing," said Spencer.
Barnett recommended everyone take a self defense class and that no one is too old to start learning self defense.
Innergetics is offering girls and women personal safety seminars on the third Saturday of each month.
If you would like more information click here.
Copyright 2012 by ClickOnDetroit.com. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


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Recession Caused First-Ever Decline in Child Support Payments: GAO
February 04, 2011 | Huffington Post | Link to article
WASHINGTON -- Total funds collected for U.S. child-support programs failed to increase during fiscal year 2009 for the first time since Congress created an enforcement arm for such collections in 1975, according to a study released this week by the Government Accountability Office.
Overall collections declined by 2.1 percent from the previous fiscal year, including the first-ever drop in collections automatically withheld from wages, long the primary source of child-support payments. The enforcement program, administered at the state level and overseen by the federal Department of Health and Human Services, collected about $26 billion in child support payments during fiscal 2009 on behalf of some 17 million children, almost one-quarter of the nation's kids. The average amount of child support collected per case dropped 3 percent to $1,670, the first decline since 1994.
The amount of child-support funding collected from unemployment checks, however, nearly tripled during fiscal 2009. It's a measure of the depths of the recession, but also of how much deeper it could have been, analysts say, without government efforts to mitigate the economic crisis.
"I think it's clear that the decline in collections isn't due to a failing on the part of child-support enforcement administrators, but due to the economy," said Elizabeth Lower-Basch, a senior policy analyst at the Center for Law and Social Policy, an advocacy group for lower-income Americans. "It would have been a bigger drop without the extended unemployment insurance benefits, which helped many noncustodial parents meet their obligations."
Nearly 9.3 million Americans are currently receiving either state or federal unemployment checks as of this week, according to the Labor Department. Federal extensions of jobless benefits can provide up to 73 weeks of aid beyond the standard 26 weeks provided by states.
The federal government spent $120 billion on unemployment benefits in 2009, and almost half of all families with one unemployed member received benefits that year, with the aid providing for an average boost of $6,000 to each family's income.
That spending prevented a record surge in the poverty rate last year, according to the Congressional Budget Office.


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Knitwear this season makes a strong fashion statement thanks to bold colors and a new graphic approach. Inspired by the artwork of Blinky Palermo and Robert Mangold, the menswear spring sweaters feature a variety of abstracted visual devices that create oversized pattern on a light canvas of fine wools and techno cottons.
The unconventional graphics are created in a variety of ways. Colored panels, for example, are knitted into the designs to create bold blocking and trims. Abstract lettering appears strongly in primary colors, while tone on tone patterns are created with jacquard-effect knitting techniques.
The shapes are streamlined and straightforward: T-shirt styles, pull overs and cardigans are offered in long and short sleeve variations. New this season are the layered pairings of knitwear: a cardigan lies over a crewneck which lies over a crisp white shirt. Fine merino wools and sheer techno materials create thin veils while a techno-cotton blend creates a more crisp body.


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THIS is the moment that a man with Asperger's Syndrome was killed with a single punch to the head.
Andrew Young died after 20-year-old Lewis Gill lashed out in November last year.
Tragically, the 40-year-old is the fourth man to die in 13 years in Bournemouth from one punch.
Now those behind a national campaign to make people think twice before acting violently have spoken out.
A spokesperson from initiative One Punch Can Kill said: "We want this campaign to make people think twice about their actions.
"Remember, if you avoid trouble, control your anger and walk away, you could not only save your life but someone else's as well."
Mr Young had previously exchanged words with Gill's acquaintance, Victor Ibitoye, who had been riding a pedal cycle on the pavement in Charminster Road.
Overhearing the exchange, Gill punched Mr Young who collapsed onto the road behind him.
He died the next day, November 7, at Southampton General Hospital.
Warning: this CCTV footage contains graphic scenes of a violent incident
This CCTV footage was shown at Salisbury Crown Court on Friday as Gill was sentenced for manslaughter.
In it, the victim, who is circled in yellow, is struck by Gill, circled in red.
Mr Young's mother Pamela was heard to gasp as she saw the footage for the first time.
Sentencing Gill to four-and-a-half years in prison, Judge Keith Cutler said: "You threw a forceful and vicious punch at [Mr Young].
"He clearly was not any physical threat."
Mr Young is one of four victims felled by a single blow in recent years.
Clive Wilcox, 42, was killed on Friday, May 4 2001 after an altercation with Daniel Scott, now 33, outside the One Stop shop in Winton.
Scott was jailed for a total of five years and one month for manslaughter and possessing and using a false passport in October last year.
Nathan Ridler, 17, was attempting to stop a fight in Bournemouth town centre when he was killed on February 24, 2008.
CCTV footage showed he had his hands in his pockets when he was attacked.
Jamie Lee Sloane, then 18, was jailed for three years and three months after admitting manslaughter.
Jason Peers, 38, was killed on the same night after being punched in the car park of the Dolphin pub in Holdenhurst Road.
Jeremy Warren, then 30, of Adeline Road, Boscombe, was jailed for three years for manslaughter.
Gill was sentenced to four years for manslaughter, and two three-month prison terms for run consecutively for committing the offence while on a suspended sentence and for handling stolen goods.


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Thanksgiving is a time to be reflect on all the things we're thankful for throughout the year. It's also a time to immerse ourselves in some seriously wonderful food! One of my favorite foods to eat during the Thanksgiving feast is gravy. It brings all the fabulous Thanksgiving food together into a harmonious plate.
Because I like to insert cheese wherever I can, here is a great, easy way to make your Thanksgiving gravy into a cheesy gravy!
Cheesy Thanksgiving Gravy
3 sprigs fresh thyme
3 sprigs fresh rosemary
3 sprigs fresh marjoram
1 bay leaf (fresh or dried)
2 sticks unsalted butter
1 cup of all-purpose flour
4 cups chicken or turkey stock (use home made for best results)
2 teaspoons ground coffee (instant coffee works, but use finely ground espresso for big flavor)
3 cups cold whole milk
Kosher salt and fresh ground pepper
A few grates of nutmeg
1 cup grated Cabot cloth-bound Cheddar (or any good sharp cloth-bound Cheddar)
Kitchen Supplies
Tight sealing jar
Make a bouquet garni by placing thyme, rosemary, marjoram and the bay leaf in the middle of a 12″ square of cheese cloth. Collect all four corners and tie with kitchen twine to enclose the herbs into a small pouch. Set aside.
Melt butter then add 1/2 cup plus 2 tablespoons of flour. Cook till golden brown. Stir in coffee and then slowly whisk in stock. Add bouquet garni and let gravy simmer on low for 45 minutes, stirring occasionally to make sure that nothing sticks to the bottom of the pan. Once gravy has reduced to about 1/3 of its original size discard bouquet garni.
Pour milk into a tight sealing jar with remaining 6 tablespoons of flour. Shake until contents are thoroughly mixed. Raise heat to medium and slowly whisk shaken milk and flour into gravy and continue to whisk until the sauce thickens and comes to a very light boil, about 2 to 3 minutes. Reduce heat back to a simmer and season with salt, pepper and nutmeg to taste. Allow to simmer for 3 minutes longer. Stir in cheese and whisk until melted. If you are feeling extra cheesy, add an additional 1/2 to 1 cup of shredded cheese!
Keep hot in a thermos and serve over your mashed potatoes, turkey and whatever other sides need a dose of it.
Yields about 4 cups


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Top Christmas Desserts
Baked goodies are always a must at holiday celebrations. This year, take Christmas desserts to a new, fresh level with one of our festive dessert ideas!
Baked goodies are always a must at holiday celebrations. This year, take Christmas desserts to a new, fresh level with one of our festive dessert ideas!
Classic recipes for pies, cupcakes, cookies and more are transformed into seasonal treats the whole family will enjoy with a tweak in ingredients or a creative decoration idea.
If you can't find that perfect treat you're looking for, be sure to check out our other cupcakes, cookies and dessert recipes!
Brightly decorated cake balls atop festive sticks make for Christmas desserts everyone will ooh and ahh over. They taste great and look wonderful displayed in a big group, plus it's a fun way to get the kids involved in Christmas baking.
Easy enough for the kids to help decorate, our red velvet cupcakes topped with cream cheese frosting and candy holly are instantly festive. Check out the video and make a batch of Christmas cupcakes at home!
Basic sugar cookies offer so many ways to get creative! Check out these adorable Rudolph cookie pops.
Lemon cookies are light and sweet, the perfect holiday treat to gift friends and family with. Give this recipe a try!
Intimdated by pie making? Don't be! This no bake pie recipe keeps things quick and easy, but tastes amazing. Christmas party guests are sure to enjoy a slice of this pie!
Though your first thought for Christmas desserts may not be ice cream, these mint cream bon bons are a wonderfully indulgent treat for the holidays. All your guests will enjoy these!
Stuffed Chocolate Strawberries
For guests looking to restrict the calorie intake this holiday season whipped chocolate filled strawberries are a perfect Christmas dessert to serve. Light, airy, yet completely decadent.
French toast may be the perfect brunch recipe, but try serving this chocolate and nutty version as a dessert. Topped with a scoop of coffee ice cream it's pretty irresistible as a Christmas dessert.
See how Dawn Sandomeno and Elizabeth Mascali elevate the every day with their fantastic recipes and ideas!Read More »


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©2005 Newt Gingrich and William R. Forstchen; (P)2005 Audio Renaissance, a division of Holtzbrinck Publishers, LLC
"A swiftly paced and authentically grounded novel....The authors' research is impeccable, and their presentation brings events down to a personal level, and, as in any good alternate vision of history, the reader is left believing it could really have happened this way." (Booklist)
"Never Call Retreat (Unabridged)"
The action is first rate, if you enjoyed the first two books then you won't want to miss this one.
"This is the best series around!!!!"
Well, very well, researched and realistic. I think it shows how a very small event can have such ernormous effect on history. I do not think that there is anything that is out of the realm in this book. Do yourself a favor and listen to this whole series...
"Incredible imagination"
This is a great 'alternative' ending to the Civil War. It reads so true with historically correct personalities, some who survived the actual war don't survive the book. The book is also breathtaking in its geographic accuracy. I happen to be in the area while listening to the book and was able to drive around some of the battle sites....and they are in real life as described in the book.
Interested in History, Politics, and Economics.
"It did not end in 1863."
I understand that it is a novel, but it is billed as Historically accurate fiction. I have read many Historically accurate books about the Civil War, but this book only served as an avenue to confuse those who are not totally current on Civil War History.
"An above average historical fiction"
An above average historical fiction told through the perceived minds of the great Generals who lived it. The story is intriguing, and the performance is superb.
"Never Call Retreat"
Outstanding. Absolutely gripping. This is an excellent "alternative history".
"Never Call Retreat"
Newt is a great historian and his books are wonderful. This one is no exception. I highly recommend it as a thought provoking read using alternative history.
"Outstanding conclusion"
This series was entertaining realistic and well read. I could not stop listening. The final part, this book, was at times like listening to a football game, I actually felt myself swept up and rooting. I actually wanted to scream "on men, on"
"Never Call Retreat"
Great story, just waiting for the next active history book!
"Exciting but gaps is historical fact"
This is the first time I have read a book from this series and I found it exciting where I was on the edge of my seat and couldn't put it down. What surprises me though is the fact battles took place in diffent places and people were killed in the story that didn't die in those battles in real history. The real story of the war is so interesting that I didn't see the need to make changes that were this big. I was just caught off guard when the story didn't follow the line of the real war.
Report Inappropriate Content
If you find this review inappropriate and think it should be removed from our site, let us know. This report will be reviewed by Audible and we will take appropriate action.


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The SDR WInnComm 2013 will be held on January 8th to 10th, 2013 in Washington DC. So if you are looking for the best B&B to stay in Washington dc, check out our beautiful Washington DC hotel which is located in the DuPont Circle area and offers complimentary breakfast and Wireless Internet with every reservation.
Jonathan, Innkeeper
American Guest House in Washington DC


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Don't have time for breakfast in the morning. All it takes is some preparation and this nifty cereal holder. It even comes with a foldable spoon. Freeze the bottom half of our Cereal-on-the-Go container before you leave home to keep milk cool. Cereal stays dry and fresh in the top compartment until it's time to eat.
The easy way to pack cereal + milk for work, school, or any other on-the-go occasion!Tags: food, kitchen, storage, containers, breakfast, organization, lunch, cereal, organizingAdded 9 Years Ago from Brylane Home


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You can now purchase the WSM at Amazon for $154 with Free Shipping.
Go to www.virtualweberbullet.com and click on the Amazon.com link at the top of the page. Add the WSM to cart, check out and apply promo code MAYREBATEKHO. Be sure to choose Free Super Saver shipping. As in February, the promo restrictions exclude Weber products, but it still works (as of now, YMMV).
Happy Q'ing!


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TALLAHASSEE, Fla. (AP) - Florida Gov. Rick Scott is asking state lawmakers put aside money in the coming year to give pay raises to the state's teachers.
A spokeswoman for the governor said that Scott will announce his proposal Wednesday in Orlando. The governor's office is not providing any additional details yet.
Scott last year pushed legislators to increase overall funding going to the state's public schools but he did not mandate that the money go to teacher salaries.
In the past GOP legislators have resisted calls to raise teacher salaries by saying it was the responsibility of local school boards to decide how much to pay teachers.
The state has roughly 168,000 teachers.
Scott is putting the finishing touches on the 2013 budget he will likely submit next week to legislators.
(Copyright 2013 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.)


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A bewildered and overwhelmed T. Raft has announced his intention to step down from his position as CEO of Shake and Collateral Co., this Thursday. Mr Raft, who has been indicted on multiple counts of jury abuse, does not seem to understand why he is suddenly reviled in public places.
"I went to purchase coffee," Raft says, "And the barista made no attempt to hide the fact that he was spitting into my coffee."
This isn't Raft's first run-in with the law. In 1976, at age five, T. Raft became the youngest person to ever be arrested. Two officers lost their lives, and it became necessary to restrain the beligerent Raft using most unorthodox methods. Fifteen years later, Raft returned to his hometown after a lengthy world tour, during which he had aimed to be incarcerated in as many countries as possible before his eighteenth birthday.
"I mostly succeeded, too," smirked the colossally irritating individual. "But, as it turns out, the Lomar Republic has the most lax laws on the planet."
His latest indictment (fourteen separate counts of assaulting jury members in a courtroom) is viewed with pride. Raft has expressed no plans to do anything about it.


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Today I have author Cynthia Gail here sharing with us her Christmas traditions.
Welcome to The Book Vixen Cynthia!
Christmas Traditions
Christmas is the only time of the year that I remember my family having traditions. It started on Christmas Eve, with my dad going to Minsky's and picking up our favorite meat lover's pizza. By the time he got home, Mom would have bread dough rising in front of the wood-burning fireplace. We'd all pile up on the couch and loveseat and eat pizza while watching Miracle on 34th Street. (The 1947 version with Natalie Wood).
On Christmas morning, we'd wake at the crack of dawn and check out what Santa had left for us.
While my sister and I investigated the tree and our stockings, Mom would use the home-made dough to make the most amazing cinnamon rolls. Melt in your mouth—to die for—butter and brown sugar—lick your fingers, kind of amazing! Christmas was the only time of the year she made them, so we savored every single bite.
Then we opened our wrapped presents. The ones officially from Mom and Dad. My mom was creative—she knew we would peek or shake, so she never used nametags. She would wrap all of my presents in the same paper, each of my sister's in a different paper, and so on. So, even though she'd have her shopping and wrapping done well in advance, nobody, including my dad, knew who each set of wrapped surprises belonged to. Once we cleaned up the paper and bows and boxes, we'd put everything away, get cleaned up, and go to Grandma and Grandpa's house for the day.
Here is my mom's Cinnamon Roll recipe:
1 pkg yeast
1/3 cup sugar
1 cup flour
1 tsp sale
Mix and set aside
Combine 1/4 cup shortening and 1 cup milk in pan on top of stove. Heat until the shortening is melted. Be careful not to let it boil or froth. Then add 1/4 cup water to slightly cool mixture. Target temperature should be between 120 and 130 degrees.
Pour the shortening mixture into the yeast mixture and use a mixer on low speed.
Add 1 slightly beaten egg
Add 2 1/2 cups flour, slowly
On a large cutting board, spread a thin layer of flour and kneed for 5 to 10 minutes. Spray the inside of a clean mixing bowl and lay dough in bottom. Cover and let rise 1 1/2 hours.
Lay dough back on the floured cutting board and roll out in a rectangle. Brush melted butter across the entire surface of dough, then sprinkle brown sugar and cinnamon. Add nuts and raisins if desired.
Starting with the long side of dough, turn over the edge and roll all the way up. Spray the bottom of a 9x13 baking pan. Add melted butter, brown sugar and more nuts and raisins to the bottom of the pan. No specific measurement—add to your taste. Cut the rolled dough into 1 1/2 inch sections with serrated knife. Place in bottom of baking pan, with generous space between each, for additional rising.
Cover and set in refrigerator overnight.
Remove from refrigerator 30 minutes to an hour before baking to bring dough back to room temperature. Bake at 375° for 20+ minutes. Tops should be golden brown. Remove from oven and flip onto baking sheet immediately.
So, what is your favorite holiday tradition?
My husband and I live in the suburbs of Nashville, Tennessee with our teenage son and three dogs. Life is busy, but when I have free time, I love to read. A math/science girl at heart and a retail analyst by trade, I never thought I'd be writing romance. But one day, a story popped into my head and I had to write it down. The fantasy, escape, and wonder of just reading multiplied by ten-fold and I couldn't stop my fingers from typing my own fairy tales.
I hope you enjoy my stories. Each one touches on modern day issues, fears, and challenges that women face every day. And each one illustrates that love is within reach if you let down those walls and allow your heart to open. Our lives and experiences are so much more meaningful when we have someone to share them with.
Cynthia's latest book is the contemporary romance, Winter's Magic (Book 1 in the Music City Hearts series).
Find the author online: website | twitter | facebook
Beth Sergeant and Nick Chester come from opposite ends of the social food chain. While he sees a beautiful woman without an agenda, she sees a wealthy playboy. Can he convince her to let go of her insecurities and take a chance on love, when challenges from his past force her to reveal her most guarded secret?
Owner of La Bella Vita, a five-star day spa nestled in the affluent suburbs of Nashville, Tennessee, Beth Sergeant knows her elite clientele first hand. She attended their private schools. She was even engaged, although briefly, to one of their most recognized bachelors. But she never fit in to their social-elite world.
After losing his parents to a car accident at a young age, Nick Chester was raised by his grandfather, the wealthiest man in Nashville. When he chooses to socialize, he has a never-ending list of exclusive events and beautiful women vying for his attention. Yet he never lets himself forget that everyone has an agenda.
Beth can't resist Nick's charm and accepts an invitation to dinner, despite her deep-seated insecurities. She proves she's nothing like other women Nick's dated and learns to trust him in return. But just as the last of their resistance crumbles and true love is within reach, challenges from Nick's past threaten to destroy everything and force Beth to reveal her most guarded secret.
Pump Up Your Book is hosting a giveaway for (1) $50 Visa Card + Winter's Magic ebook and (4) Winter's Magic eBooks + Swag with each.


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The Official Moog & Switched On video flyer for our show is out!!
Submitted by switchedon on
Here it is! SXSW has descended upon our fair city of Austin! Switched On for the third year in a row has partnered up with Moog Music to present a fine showcase of electronic artists.
You can read more about the event here!
Our friend Noah Spiderman made an incredible video flyer to circulate the net.
Check out more of his work at:


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ReBuS (Looks Even Worse Than It Really Is!)Rebus brain teasers use words or letters in interesting orientations to represent common phrases.
What's the rebus, here?
HintTwo letters in the word are, in a significant way, different from the other two letters in the word. Identify and describe that difference and you might get the rebus.
Answerblow out of proportion
The letters "L" and "W" are upper case and the letters "b" and "o" are lower case. That is abnormal and, therefore, "out of proportion" for the normal spelling of a word.
"Blow out of proportion" is an idiom meaning to behave as if something that has happened is much worse than it really is.
Example of use: "BBjr has taken the position that rebuses using full sentences is a question that some people completely blow out of proportion when compared to rebuses with no supporting data or "story".
Origin of use : Probably a variant of "making a mountain out of a molehill" by use of the definition of "blow" as "exaggeration" or "puffery".
What Next?
See another brain teaser just like this one...
Or, just get a random brain teaser
If you become a registered user you can vote on this brain teaser, keep track of
which ones you have seen, and even make your own.
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BAYTOWN, Texas - Police are searching for the thieves who broke into several cars in the Baytown area.
Investigators said the thieves targeted unsuspecting drivers over the course of a few hours on January 17th. They got away with thousands of dollars worth of valuables.
"It just disgusts me that people are doing this," said one victim. "I would have never thought that it would happen to me because I was parked right next to an IHOP where people could see my truck."
The victim, who did not want to be identified, said he was eating at the restaurant along Garth Road when he came out to find his truck window shattered.
"My backpack was gone. My laptop was in there, calculator was in there," he said. "It was like over $1,300 worth of electronics just in my backpack."
Police said that evening, officers responded to at least five car break-ins in the same area.
Baytown resident Tonya Reed said she's not surprised. She was also a victim of a break-in recently at a nearby shopping center.
"I had a lot of friends that had stuff stolen," Reed said.
Copyright 2013 by Click2Houston.com. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


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Cancer.Net Specialty Editor: Childhood Brain Tumors
St. Jude Children's Research Hospital, Memphis, TN
Dr. Amar J. Gajjar is the Scott and Tracy Hamilton Endowed Chair in Brain Tumor Research as well as the Co-Chair of the Department of Oncology, Director of the Neuro-Oncology Division. He is also Co-Leader of the Neurobiology & Brain Tumor Program at St. Jude Children's Research Hospital in Memphis. Dr Gajjar is also the Chair of the Brain Tumor Committee for the Children's Oncology Group.
After earning his medical degree from Grant Medical College in Bombay, India, Dr. Gajjar completed a residency program in pediatrics at the University of South Florida. Dr Gajjar completed his fellowship in pediatric hematology oncology at St Jude Children's Research Hospital in Memphis TN and completed an additional year of fellowship in Neuro Oncology.
Dr. Gajjar is co-author of over 220 papers, many of which have contributed to the improved clinical care of children with medulloblastoma and other pediatric brain tumors. In addition to being certified by the American Board of Pediatrics in Hematology/Oncology, Dr. Gajjar is a member of ASCO, the American Association for Cancer Research, and the American Society of Pediatric Hematology Oncology.
In the past two years, Dr. Gajjar has served as a consultant/advisor for Celgene and received research funding from Genentech.
Last updated: November 2015


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A CCTV image has been released of a man who fraudulently claimed winnings at a bookmaker.
Police say the man acted in partnership with a staff member at William Hill in Lea Bridge Road, Leyton, to alter an electronic betting record and falsely claim £700 on March 26.
The CCTV image has been released to the Guardian as part of a joint venture with the Metropolitan Police to identify potential perpetrators of unsolved crimes in the borough.
Anyone with information should contact Waltham Forest police on 101 or call Crimestoppers anonymously on 0800 555 111.


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Baltimore County Police are asking for the public's help identifying a man responsible for an armed robbery in the 100 block of Symington Avenue, 21228.
At approximately 10:24 p.m. on December 5, the suspect robbed two women of their property, and then used one of the stolen credit cards at nearby convenience stores. He used a stolen credit card to purchase a carton of cigarettes at the Royal Farms store in the 3500 block of Washington Boulevard, 21227. The suspect then went to the High's store in the 1000 block of Maiden Choice Lane, 21228 and bought more cigarettes.
Two photos of the armed suspect are posted below.
Reward Offered
Anyone with information is asked to call the Baltimore County Police Department at 410-307-2020.
Tips can also be submitted to Metro Crime Stoppers at 1-866-7-LOCKUP (1-866-756-2587). To text a message to Metro Crime Stoppers, send to "CRIMES" (274637), then enter the message starting with "MCS," or email a tip to www.metrocrimestoppers.org. Those contacting Metro Crime Stoppers and MABS can remain anonymous and might be eligible for a cash reward of up to $2,000.
Suspect Photos
The below photos are of the armed robbery suspect.


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About the Book
Don't have time to go onine... or do you prefer to have recipes right in your hand? Straight from the delicious website "Recipes From Home - Online" you can have all the sweet tooth recipes at your finger tips!! From cookies to cakes and pies to pudding and so much more!! The first in a scrumptious series from Florences' site... you don't want to exclude this book from your collection!!
About the Creator
I am a stay at home mama for Johnathan (4) and Kathleen (2) and a stay at home wife for my hubby!! We have a homestead where we grow our own food - yes, that includes meat, too!! - make our own soap and have fresh milk and eggs everyday!! I have a website with my neighbor where we present information - against the grain - on pregnancy, childbirth and beyond!! In the AZ desert sometimes it just gets too hot to enjoy the outdoors, so I have found that writing - or at least pulling information together - is a nice outlet when I have spare time!! I hope that you enjoy what I share... because I enjoy the time I spend on it!!!
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McDonald's: An Inspirational Brand
October 11, 2012
How does a brand close the gap between customer perception and company reality? McDonald's stands for great-tasting quality food, great people, and strong community partnerships. The brand is committed to doing what's right for all customers and offers more variety and balance in its menu than ever before. But as the industry leader, its reputation is frequently called into question. Serving 28 million people a day in the United States, McDonald's has the ability to change the conversation. Neil Golden, Senior Vice President & Chief Marketing Officer, McDonald's USA, LLC, discussed how a brand must evolve and share its story in a way that inspires people to listen.
View highlight video below.
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Cole Cisbani Uses Knowledge of Course to Collect Qualifier
SAINT LEO, Fla. – Former Saint Leo men's golfer Cole Cisbani is back in the news as he qualified for the Florida State Open at his former home course, the Lake Jovita Golf and Country Club, earlier this week.
Cisbani fired the second lowest round of the final day as he posted an even-par 72. Playing through an extremely wet course, the former Lion compiled three birdies and 12 pars to earn his spot in the tournament.
He struck on 12-of-14 fairways and 14-of-18 greens and averaged 327 yards-per-drive. In qualifying for the Open, Cisbani used consistent irons and a strong putting game to solidify his spot.
After the round, Cisbani mentioned, "I made a few mental mistakes that kept me from shooting under. I will be at the course tomorrow to work on a few things, but making the qualifier is rewarding".
Cisbani is the son of current Men's Golf Coach Ray Cisbani.
The former Lion competed with the Green & Gold from 2007-2010 where he helped the Lions to their first team NCAA Regional appearance in school history as a senior in 2010.
The Florida State Open Finals well be held at Black Diamond Country Club from July 15-17.


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The Pougialis Fine Art Award is a yearly competition that offers promising Fine Art students an opportunity to study as an apprentice with a senior artist of national and international standing for one semester and have an exhibition in the Averill and Bernard Leviton A+D Gallery. Scholarship applicants are expected to produce and later install creative work for the competition. In addition, the award is to help defray the cost of tuition.
The Pougialis Fine Art Award is open to:


text: Daughter of Jas. Stirling, Sr., and Jennet Chamberlain, and wife of Pleasant Hill Carmichael, whom she married in Johnson Co., MO, on 11 Nov. 1841. The Carmichaels had three children--James S., Susan J., and Hamilton Hill--in the 1840s. Both Pleasant Hill and son James served in the Confederate army and both died near Corinth, MS, in 1862. Catherine's same is sometimes spelled "Catharine" in documents.


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SEVEN men were arrested this morning during a series of dawn raids in connection with football related violence.
Warrants were executed between 6am and 6.30am at five residential addresses in Swindon and two in Wantage to arrest outstanding offenders for violent disorder.
All seven men, aged between 17 and 47, remain in custody at Gablecross Police Station at this time.
The disorder took place at 7pm on Saturday April 12 in the Manchester Road area, close to the Tap and Barrel pub. The incident took place straight after the Swindon Town Vs Brentford football match.
The warrants took place following detailed police enquiries after the incident due to the large numbers of people involved.
Officers from across the Force were used in the operation, including support from specialist officers from the Tri-force collaboration with Gloucestershire Police and Avon and Somerset Constabulary.
As part of the operation there has been close liaison between Local Crime Team investigators, Football Intelligence Officers, Central Sector Neighbourhood Policing Team and the Licensing Officers at Wiltshire Police.
Inspector Paul Saunders, Sector Head for the Town Centre, said: "A lot of time, effort and planning has gone into identifying these offenders, gathering all the required evidence and preparing for the early morning arrests which we have carried out today.
"The disorder was disgraceful and had a knock on effect for the local community. It also brings with it unwanted associations for the football club.
" The actions of these people tarnish the reputation of real football fans, who are actually interested in the game and what is taking place on the field, and not the drunken brawling which a minority seem to be focused on.
"The message for those involved is quite simple: just because you don't get arrested on the day does not mean that we won't be coming for you at some point in the future, and certainly doesn't mean you have got away with it.
"If we can identify you, then you will be getting that early morning knock on the door and we will hold you to account for your actions."
As part of the investigation into this incident, Swindon Licensing Officers are also working with the owners and management of The Tap And Barrel public house.
Wiltshire Police Licensing officer Sian Kalynka, said: "Alcohol is often a contributing factor in incidents such as this and, from a licensing perspective, we have to make sure that licensed premises linked to these type of offences are also engaged as part of the investigation.
"Responsibility under the Licensing Act does not necessarily stop when people leave a venue, if a causal link can be proven then a venue can face serious consequences, which is why early engagement with landlords and owners is key to preventing future disorders."


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Hi all,
As if she didn't already have enough reasons, gave the Mrs. one more reason to laugh at me:
please help me w/ the post mortem...!
I set up the 3 grill zone, and the hot zone was WAY hot.
I think where I messed up; I brushed the steak w/ olive oil. Don't ask me why...i wasn't thinking completely and figured "this'll help me get it off the grate.."
From the moment I put the steaks on, huge flames were all over the steaks.
I tried to move them, but pretty much anywhere I put'em they were very flame-engulfed.
1. are flames normal?
2. are the flames likely caused by that olive oil coat i brushed on'em?


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HOUSTON - We hear the numbers, see the surveillance photos and even watch the getaways on TV. Bank robbers struck 160 times across Houston in 2012. That's twice as many robberies as the year before.
But this is the story of how one of those bank robbers hit banks inside grocery stores and the amazing way FBI investigators caught him.
"The victims of these robberies often times aren't just the banks," said FBI Special Agent Stephen Morris, head of the FBI's Houston division. "It's the people out shopping going about their everyday business."
Kyle Lee Puglisi, 27, became known as the "bearded bandit." He was accused in five Houston robberies -- all inside grocery stores.
The trail began inside a Kroger on Highway 6 in Copperfield. FBI investigators said Puglisi walked in the store, grabbed a cart and acted like any other shopper. He would cruise the aisles, putting items in his cart.
His target: a First Convenience Bank branch located inside the store.
"Everybody goes to the grocery store," said Dr. Mark Kellar, a retired sheriff's major and criminal justice professor at the University of Houston-Downtown. "So you can kind of blend in to that kind of environment much easier than a traditional banking environment."
Investigators believe Puglisi would shop until he saw a break in security. Then, he showed a gun and passed a note to the teller saying, "Don't make it obvious." Court documents obtained by Local 2 read that Puglisi ran away with a total of $7,636. However, surveillance cameras got a clear look at him.
It was the same method at each grocery store bank Puglisi targeted, investigators said.
At a Joe V's on the Houston north side, court documents show Puglisi shopped, approached a bank teller and walked out with $3,327. At an HEB on Spring Cypress near Interstate 45 North, investigators said he robbed the First Community Credit Union branch for another $3,380.
Documents read Puglisi would use a bike to ride to his getaway truck parked far away.
Investigators said before each robbery, Puglisi would put a Band-Aid on the tip of each finger to keep his fingerprints off the carts or anything else. Turns out, that wasn't enough.
At Puglisi's first robbery, he left his grocery cart and the things inside near the bank. The FBI processed the cart and items for DNA evidence and ran that evidence through its national database. When the results finally came back, investigators said the results all pointed to Puglisi, who had a criminal record.
FBI agents tracked Puglisi to a motel on the North Freeway, found Band-Aid wrappers in his truck and arrested him.
Bank tellers picked him out of a lineup.
Puglisi pleaded guilty to the bank robberies in federal court and now faces up to 20 years in prison. He's scheduled to be sentenced next month. Local 2 made several attempts to contact Puglisi through his attorney. Those calls were never returned.
Copyright 2013 by Click2Houston.com. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


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The Crap We Missed – Tuesday 8.13.13
Welcome to Tuesday's The Crap We Missed, a special edition you would call it if you weighted this feature with the type of over importance that I do because its got back-to-back doubles of Terrence Howard and Doutzen Kroes. You don't choose between those, you just upload them and watch the Internet unicorn you've created tap dance across a rainbow. It's clear that I've embraced the fact that you all just come here for the butts, and no longer read anything down here, right?
Glad we're on the same page,
- Photo Boy
Click Here To Start The Gallery
Photo: Bauer-Griffin, Fame/Flynet, Getty, INFdaily, Pacific Coast News, Splash News, WENN


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WHEN you set off on a road to achieve something you never quite know where it's going to lead.
For Angus Roberts the Residential Letting specialists in Ilkley, the Tour de France seemed like a great opportunity to do something that could provide a little more to some less fortunate than those living in the many villages that 'Le Tour' would visit.
So they decided to try to raise money for a Bradford based charity, One In A Million (OIAM), who give hope and opportunities to disadvantaged children from some of the poorest estates in Bradford.
One In A Million, co-founded nine years ago by former Bradford City AFC player and assistant manager Wayne Jacobs, provide community based sports, arts and enterprise programmes to children and young people, who live in disadvantaged areas of Bradford.
They invest hope into their lives to help change the negative statistics that hover over their lives, so that they can thrive socially, educationally and in their well being. The charity helps over 700 children every week and relies on the support of local businesses and the general public who want to make a difference.
Angus Roberts' goal was to raise sufficient money for one child, but in the end achieved, enough for three children to benefit from their programme.
They raised the money through the Angus Roberts 'Bikethon', which saw staff seeing how far they could cycle in a working day. The bike was ridden in turn by the team,made up of David, Leigh Carr, Emily Thwaites, Jayne Burdon and Mark Robinson along with Wayne and Craig from OIAM, on a bike kindly loaned to them for the day by Ilkley Cycles.
On Friday, July 4 they 'Rode the extra Mile for OIAM' and managed to raise over £2,000, enough to sponsor not one but three children! And with only sore legs to suffer for it!
Director of Angus Roberts, David Waterhouse said after the event: "We are frankly humbled by the generosity, kindness and support that we have been shown by our landlords, contractors and friends.
"We have managed to achieve a target that we never dared hope was possible! And for the Angus Roberts team we had fun and enjoyed an amazing team building day!"
Charity co-founder Wayne Jacobs who also joined the bikeathon said: "It was a real pleasure to spend the day with the Angus Roberts team, who generously gave up their time and definitely rode the extra mile to support our work with disadvantaged young people.
"They have a great team with big hearts and to achieve three times their original goal is simply outstanding. They are One In A Million!"


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The Long Ride to Anywhere
You know, no one's going to look as good as Obama did out there two years ago. But not everyone's going to thank him, either: the House is already a lock for the GOP, says our pal Nate Silver, so we're sticking to the races that still matter — the diverse gubernatorial fields and nail-biter Senate races where a dapper debate or killer tie could make a difference. Subconsciously, at least. In our relatively unscientific but extremely discerning examination of more than 150 toss-up and standout races these past two weeks, we decided a couple things: hopefuls from the coasts dress well (maybe because they have to), Southern men have more room to improvise (and fail), while the Midwest — well, no one from the Midwest made our list. Which probably says a lot about how polarized this nation looks in late 2010: average-looking might be the new populist style, but here's hoping we're wrong.
The temperature's too damn hot for gloves — at least inside, at a debate, even you steal the show. And the tie — that's too damn loose. But the martial-arts instructor turned activist certainly has flair, and half of great style is confidence. With the kind of hair that is neither on your head nor your face but some kind of amorphous blend that does nothing so much as distract voters from the competition, the rest is all forgiven.
The Takeaway: A dignified man matches his beard to his face shape, but carries a softer stick.
The 2010 Watch Awards


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Product details
Dulux Easycare Matt uses stain repellent technology that allows you to free yourself from the worry that everyday living will damage the look of your home. *This exceptionally tough and washable paint repels common liquid water based spills making them easier to wash away. Dulux Easycare is 20 x tougher than standard Dulux Matt so you can remove common household stains without damaging the paint on your wall, keeping your home looking great for longer.
- Colour: Denim Drift
- Size: 2.5L
- Coverage (per litre): 13sq m
- Coverage per tin: 32.5sq m
- Effects and finish: Matt
- Features: 20x tougher than standard Dulux Matt, Unique stain repellent technology to repel liquid spills
- Usage: Do not apply in very damp or humid conditions or extreme temperatures.
- Number of coats recommended: 2
- Drying time: Leave 4 hours to dry
- Time to recoat: 1 hour
- Washable: Yes
- Waterproof: Yes
- Wipeable: Yes
- Interior exterior usage: Suitable for interior use
- Additional information: TIP: if the colour change is strong, more coats may be required. If you use more than one can, mix them together in a large container or finish in a corner before starting a new can.
- Weight: 2.5kg
Dulux Easycare Denim Drift - Matt - 2.5L 423047
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{"calculators": { "calculator": { "pimProductAttr": ["13.0", "L", "2.5", "2"], "calcType": "paint-calculator" } } }
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Support independent journalism in Central & Eastern Europe.
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by Vladimir Kozlov
18 June 2008
Limonov's latest may not win him many votes but will cement his reputation as the master of paradox.
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Going on Assignment in Prague – January 7-15, 2018
Do you have a passion for foreign reporting? Would you like to develop your skills further or simply gain more confidence? This course is aimed at university students, freelance journalists or activists who would like to gain some practical skills in this field. You'll learn the best tricks of the trade from storytelling and interviewing techniques to locating your sources and incorporating multimedia.
Throughout the course you will be guided by experienced foreign correspondents from media such as Reuters, the BBC, the Financial Times, and the New York Times. You'll leave equipped with a publishable story to add to your portfolio. Early bird fee available until September 1, 2017. Apply now! or see more info.


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"Game changer" is a term you hear often when people talk about how technology has changed their industry.
It is tougher than ever for sales teams to cut through the clutter and differentiate with prospects. But who can blame them? Sales teams can't find the right resources, so they spend less time selling than hunting for resources, which means lost opportunities – leading to overall poor sales performance. The facts regarding the buying environment and sales execution are startling:
Here are three new rules of sales execution to give you a fresh approach to stop enabling the poor behavior and start executing.
Rule 1: Conversations, Not Collateral
Organizations have been enabling sales teams with collateral and sales tools to the point of burdening them with too much information. There is a multitude of sales and marketing collateral loaded into sales portals or intranet sites, and countless hours are spent creating, editing, and producing this content. This approach is flawed not only in that it is not aligned with current selling situations and disconnected from daily reality, but also becomes incredibly difficult to know if sales teams have even used the content, and how effective it really is.
The shift needs to focus on the desired business outcome. Effective salespeople not only understand the buyer's marketplace and business issues, but also help them envision solving their problems using their products and services. They get stalled deals moving, present greater value and are able to seamlessly sell new products or cross-sell existing product sets.
Enabling your sales teams with content won't guarantee they are having these valuable conversations with prospects.
Sales knowledge is much more than a stack of data sheets or four-color glossy brochures. This goes well beyond what companies are packing into their sales portals today.
Rule 2: Expertise Beats Product Knowledge
Buyers buy from the vendor who understands their business and the challenges they face the best, and who delivers a clear vision of how to solve them. Often, a great deal of time is spent trying to communicate value and differentiation of a product or service, and a number of salespeople don't see how other reps do this or what they are using and doing to win deals.
No matter how much time marketers and product managers spend with salespeople and customers, they just don't see enough of what happens at the moments of truth – how buyers are receiving and responding to the messages the sales team delivers. Just look how fast the competitive landscape, the needs of the marketplace, and the product portfolios change. A top-down approach will never keep up.
Sales teams ignore 90% of the "selling collateral" that is provided to them.4
Through trial and error, your salespeople learn something new every day about what works and what doesn't. In this changed buying environment, it's critical that your sales and marketing teams collaborate to unlock this treasure. It's about capturing feedback on what works and doesn't work, and using that feedback to continuously improve the base of knowledge.
Rule 3: Proven Plays
One thing that sets top salespeople apart from the rest of the pack is that they will never "wing it." Top reps do the same set of things that have helped them win similar deals in the past. You might say these top performers have a set of repeatable playbooks in their head that have been developed and adapted through years of experience in front of customers.
Average or low performers typically think they are not hitting it out of the park because they just need more at-bats. The problem is they can't swing the bat like top performers. Often companies roll out a new sales methodology believing that is the missing link to improving sales performance.
A methodology alone won't move the needle.
We want more top performers, so we spend thousands of dollars on sales training events with the hope that methodology and training will give our reps the knowledge, skills, attitude and structure to become stars.
But it doesn't work. Studies show that the average salesperson forgets 87% of what they learn in sales training within 30 days.5 The rep gets back to the office, puts the training binder on the shelf, reverts to old habits, and continues to follow the path of least resistance. A sales methodology or process is essential but they usually don't have the impact they could because there's no practical way to follow them. A methodology tells you why to do something, but it doesn't tell you what to do in a specific situation, when to do it, or how to do it.
No amount of training is going to enable a sales rep to be ready to handle every selling situation he or she will encounter.
In order to empower sales to achieve their revenue goals companies need to equip sales teams differently so they can execute effectively. We can't keep expecting a different outcome when using the same old approaches. It's time we made new rules to sell by.
Amanda Wilson is Director of Product Marketing & Programs at Qvidian, the innovator in sales execution solutions.
1Sales Benchmark Index
2CSO Insights
3Bridge Group
5Corporate Executive Board


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Saracatinib in Treating Patients With Stage III or Stage IV Melanoma That Cannot Be Removed By Surgery
- Full Text View
- Tabular View
- Study Results
- Disclaimer
- How to Read a Study Record
|Recurrent Melanoma Stage IIA Melanoma Stage IIB Melanoma Stage IIC Melanoma Stage IV Melanoma
|Drug: saracatinib
|Phase 2
|Study Type:
|Study Design:
|Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
|Official Title:
|A Phase 2 Study of AZD0530 in Metastatic Melanoma
- Objective Response Rate [ Time Frame: Up to 25 weeks ]
Response will be evaluated in this study using the Response Evaluation Criteria in Solid Tumors (RECIST). A sum of the longest diameter (LD) for all target lesions will be calculated and reported as the baseline sum LD. The baseline sum LD will be used as reference by which to characterize the objective tumor response. Complete Response (CR), Disappearance of all target lesions; Partial Response (PR), >=30% decrease in the sum LD; Objective response = CR + PR.
CT scans will be performed at baseline and every 4-8 weeks while on study.
- Progression-free Survival [ Time Frame: Up to 2 years ]Progression will be evaluated in this study using the RECIST criteria (the appearance of new lesions and/or at least a 20% increase in the sum of diameters of target lesions, taking as reference the smallest sum on study). Progression-free survival time was calculated as the time from treatment start to date of progression or death, whichever comes first.
|Study Start Date:
|July 2006
|Study Completion Date:
|January 2011
|Primary Completion Date:
|January 2011 (Final data collection date for primary outcome measure)
|Assigned Interventions
Experimental: Saracatinib
Patients receive saracatinib 175 mg oral once daily in the absence of disease progression or unacceptable toxicity.
Drug: saracatinib
Other Name: AZD0530
Detailed Description:
I. To determine whether the Src kinase inhibitor, AZD0530 (saracatinib), has single agent clinical activity in patients with advanced melanoma.
II. To determine whether this drug will increase progression-free survival of these patients from 3 months to 4.5 months.
I. To determine whether this drug may inhibit the activation of peripheral blood T cells analyzed ex vivo.
Patients receive saracatinib orally (PO) once daily (QD) in the absence of disease progression or unacceptable toxicity.
|Ages Eligible for Study:
|18 Years and older (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
Histologically or cytologically confirmed metastatic melanoma
- Stage IV or unresectable stage III disease
- Measurable disease, defined as ≥ 1 lesion that can be accurately measured in ≥ 1 dimension (longest diameter to be recorded) as ≥ 20 mm by conventional techniques or as ≥ 10 mm by spiral computed tomography (CT) scan
- No known brain metastases
- Eastern Cooperative Oncology Group (ECOG) performance status (PS) 0-2 OR Karnofsky PS 60-100%
- Life expectancy > 12 weeks
- White blood cell (WBC) ≥ 3,000/mcL
- Absolute neutrophil count (ANC) ≥ 1,500/mcL
- Platelet count ≥ 100,000/mcL
- Hemoglobin ≥ 9 g/dL
- Total bilirubin normal
- Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≤ 2.5 times upper limit of normal
- Creatinine normal OR creatinine clearance ≥ 60 mL/min
- Proteinuria ≤ 1+ by dipstick OR 24-hour urine protein ≤ 1 g
- Not pregnant or nursing
- Negative pregnancy test
- Fertile patients must use effective contraception prior to study until completion of study treatment
- No history of allergic reactions attributed to compounds of similar chemical or biologic composition to AZD0530
- No QTc prolongation (defined as a QTc interval ≥ 480 msecs) or other significant electrocardiogram (ECG) abnormalities
- No poorly controlled hypertension (e.g., systolic blood pressure [BP] of ≥ 140 mm Hg or diastolic BP of ≥ 90 mm Hg)
- No condition (e.g., gastrointestinal tract disease resulting in an inability to take oral medication or a requirement for IV alimentation), prior surgical procedures affecting absorption, or active peptic ulcer disease that impairs the ability to swallow AZD0530 tablets
No intercurrent cardiac dysfunction including, but not limited to, any of the following:
- Symptomatic congestive heart failure
- Unstable angina pectoris
- Cardiac arrhythmia
- No recent history of ischemic heart disease including myocardial infarction
- No uncontrolled intercurrent illness including, but not limited to, ongoing or active infection or psychiatric illness/social situations that would limit compliance with study requirements
- No other malignancy within the past 5 years, except definitively treated, localized, nonmelanoma skin cancer or low-grade cervical neoplasm
- At least 4 weeks since prior and no more than one prior treatment regimen for advanced disease
- No prior kinase inhibitor with activity against Src kinases for metastatic melanoma
- More than 4 weeks since prior luteinizing hormone-releasing hormone agonists
- No concurrent combination antiretroviral therapy for human immunodeficiency virus (HIV)-positive patients
No concurrent prohibited cytochrome P450 3A4 (CYP3A4)-active agents or substances
- Prohibited drugs should be discontinued 7 days prior to the administration of the first dose of AZD0530 and for 7 days following discontinuation of AZD0530
- No other concurrent investigational agents or commercial therapies
Please refer to this study by its ClinicalTrials.gov identifier: NCT00669019
|United States, Illinois
|University of Chicago Comprehensive Cancer Center
|Chicago, Illinois, United States, 60637-1470
|Principal Investigator:
|Thomas Gajewski
|University of Chicago Comprehensive Cancer Center
|Responsible Party:
|National Cancer Institute (NCI)
|ClinicalTrials.gov Identifier:
|NCT00669019 History of Changes
|Other Study ID Numbers:
N01CM62201 ( U.S. NIH Grant/Contract )
CDR0000594729 ( Registry Identifier: PDQ (Physician Data Query) )
|Study First Received:
|April 26, 2008
|Results First Received:
|December 10, 2013
|Last Updated:
|May 6, 2014
Additional relevant MeSH terms:
Nevi and Melanomas
Neuroendocrine Tumors
Neuroectodermal Tumors
Neoplasms, Germ Cell and Embryonal
Neoplasms by Histologic Type
Neoplasms, Nerve Tissue
Antineoplastic Agents
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
ClinicalTrials.gov processed this record on August 23, 2017


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Boot Barn Item #: 2006053
Color: Click a button belowcolor
size: Click a button below Size Chartsize
width: Click a button belowwidth
- Full-grain leather
- 9 ½" shaft height
- Hallmark harness ring
- Round toe
- Leather outsole
Get a pair of boots balanced between western chic and fashionista. These Carmen Harness Boots feature a sloping collar and relaxed full-grain shaft. The leather pulls and hallmark harness ring are highlighted with detailed precision embroidery stitches—it is accents like these that make a boot shine, and these Frye Boots definitely do. Pair with black jeans and a blouse of your choice for an instantly fashionable outfit.
Style(s): 77372-DBN, 77372-GRY, 77372-BLK
Toe Type: Round
Outsole: Leather
Lifestyle: Western
Heel Type: Cowboy
Upper Material: Leather
Shaft: 9 1/2"
Material: Leather
Color: Dark Brown
Product Weight: 6 lbs
Closure: Pull-On
Print Frye Boots have been the standard for western boots since 1863 when John A. Frye, a prominent English shoemaker founded the company. It is still to date, the oldest continuously operated shoe company in the United States. Frye Boots was run by John Frye until 1911 until his death and then was taken over by his family until 1945. Frye Boots remains a signature of tradition and quality boot making. Frye Boots go back to the time of the Civil War. Frye Boots were worn by Confederate and Union soldiers as well as Teddy Roosevelt's "Rough Riders" during the Spanish-American War. Even when the earlier settlers began pioneering west, many of the adventurous New England families were wearing Frye Boots. Frye is as much a part of American History as apple pie. They are more comfortable too. The famous Frye Harness Boot continues to lead the charge and draw influence from the American Cavalry of those very early years. Even during a trip in 1938 to Washington, DC, Frye Boots we requested to be custom made for a US Navy Admiral. All throughout World War II, Frye provided custom boots for officers as well as supplying thousands of service men with Frye Wellingtons (aka Jet Boots). Frye Boots have traveled the world on the feet of brave and courageous servicemen. Even steel hard General George Patton wore a pair of Frye Boots. The classic Frye Harness Boots will forever hold a place in American History and stay rooted in the heart of American Culture. Frye's styles are as timeless as their reputation. Frye takes pride in providing boots that are benchcrafted from the finest full grain leather uppers with genuine leather and premium rubber soles. With Frye's dedication in creating the perfect boots down to the smallest detail, it takes over 190 steps to make a single pair of Frye Boots. Now that is quality you can count on. With the proper care, Frye Boots will last forever. Frye doesn't only make quality Western Boots, Riding Boots or Motorcycle Boots. Frye Boots can often be seen in the streets of busy cities and towns. Not to mention the countless celebrities that are in fashion magazines and can we seen often wearing a great pair of Frye Boots. Frye is a huge part of Americana and they proudly hold a place in American culture and style.


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The National Multiple Sclerosis Society chose Stamoules Produce Co. to receive its Sylvia Lawry Founder Award.
Stamoules received this honor for forging a creative new partnership to raise MS awareness throughout the U.S.
During March 2012, a portion of proceeds of Stamoules broccoli sales supported the chapter's direct services for people with MS and their families, as well as funded research for better treatments and a cure, according to a news release.
Stamoules also helped raise public awareness of MS by co-branding all of its broccoli boxes with the National MS Society's "We joined the movement" logo, according to the release.


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Ways to Give
Contact Information
Katie Williquette
(608) 263-0160
UW Carbone Cancer Center
600 Highland Ave, K4/646
Madison, WI 53792-6164
Your gift to the UW Carbone Cancer Center supports innovative research initiatives, compassionate cancer care, and education for public and health care professionals.
Your contribution also enables our researchers to explore new ideas, purchase new cancer research technology and develop better methods of diagnosing, treating and preventing cancer.
Make a Donation to UW Carbone Cancer Center
Ways You Can Support UW Carbone Cancer Center
Funding for the Cancer Center's research, outreach and treatment programs is more important than ever. There are many ways to support the UW Carbone Cancer Center in addition to your donations.
Memorial and Honor Gifts
Recognize loved ones in a special way by donating in memory or in honor of a loved one.
- Memorial gifts are made in memory of family members, friends or colleagues who have passed away
- Honor gifts show someone in your life a measure of affection, admiration or gratitude
Learn about the different ways you can give in honor or memory of a loved one
Gift Planning
You can continue to make a difference for years to come through gift planning. There are many different ways you can support the UW Carbone Cancer Center and realize a tax benefit for your estate.
Planned gift ideas include:
- Endowments
- Assets including stocks and bonds
- Bequests (wills)
Life income gifts such as charitable remainder trusts and gift annuities
The Carbone Cancer Center can also be named as a beneficiary of retirement plans, trusts or life insurance policies. The Office of Gift Planning at the University of Wisconsin Foundation can assist in planning these gifts. Please call (608) 263-4545 for more information.
Other Examples of Giving
Other examples of giving include:
- Corporate and matching gifts
- Purchasing research equipment
- Funding fellowship or research programs
- Sponsoring special events
- Underwriting programs for the community or health care professionals
Supporting Organizations
The UW Carbone Cancer Center is grateful for the support of organizations who have held fundraisers in support of patient programs and cancer research.
- Ann's Hope Foundation for melanoma support
- Forward Lymphoma for lymphoma support
- GRACE - Greater Richland Area Cancer Elimination, Inc. for general cancer support
- Our Hope of Burlington for general cancer support
- Tomorrow's Hope for general cancer support
The University of Wisconsin Foundation is the official fundraising and gift receiving organization for the Cancer Center.


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I love wings so much, it just seemed natural to see if I could somehow incorporate Hatch Chilies into them. Looked around the internet for awhile, but I couldn't for the life of me find a recipe that included Hatch and wings. Found a few that used green chilies, but not Hatch. So I took one and used it as a base to come up with my own recipe.
First thing was to roast the chilies and peppers at 500F on the Mini to get them all charred up.
The chilies and peppers were then skinned, deveined and deseeded and tossed in a food processor along with the rest of the ingredients for a marinade. Wings got marinated for about 3 hours. Then I removed the wings from the marinade and brought it to a boil for ten minutes so I could use it as a baste while the wings cooked. The Egg was set up for a raised direct cook at 400F.
I grilled the wings for about 30 minutes, basting them every 5 minutes. And of course, when I have wings, I usually have tots.
All I can say is WOW!
Those were some good wings, easily landing in my top 5. Not too spicy, just a bit of a burn on the lips, but the fresh squeezed limes really made it unique. Gonna have to make these again. I just hope that if I use Anaheim peppers once Hatch Chile season is over that they will be just as good.
•5 Hatch Chilies (I suppose you could use Anaheim if Hatch isn't available), roasted, skinned, de-veined and de-seeded
•2 jalapenos, roasted, de-veined and de-seeded
•3/4 cup of freshly squeezed lime juice
•1/4 cup olive oil
•1 Tbsp soy sauce
•4 cloves of garlic
•2 Tbsp paprika
•1 Tbsp McCormick's Grill Mates Lemon Pepper with Herbs
•1 Tbsp sugar
•1Tbsp salt
•1/8 tsp cayenne pepper
•2.5 lbs chicken wings
Toss everything in a food processor, but the wings, then let marinate. I went 3 hours as that was all the time I had, longer would probably be bettter and hotter. Remove wings, reserve marinade. Bring marinade to a boil, reduce and let simmer for 10 minutes. Grill wings 400F raised direct for about 30 minutes, basting and turning every 5.


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This term refers to the suburb Springdale in Cincinnati, Ohio. This area is home for a popular mall, big movie theater and many restaurants. This is the former home of many elderly white people to now a younger generation of blacks and hispanics. Some of the most poppin' places around is Perkins and the BP gas station right across the street from it, the rec (which is located in the ghetto of DaleSpring) where many 'substances' are transported and all the many local parks in the area where booty calls and other sexual acts occur. This is NOT your average neighborhood and it's becoming more 'hood' everyday. So, don't ever be afraid to holla at somebody in da DaleSpring, they won't hurt you, but they may ask you for something...
by bigboi June 08, 2005
The Urban Dictionary Mug
One side has the word, one side has the definition. Microwave and dishwasher safe. Lotsa space for your liquids.Buy the mug


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JOHANNESBURG (AP) -- A senior U.S. official says the defection of the Syrian prime minister and other top government ministers is more evidence that the Assad regime "is crumbling."
The American official traveling with Secretary of State Hillary Clinton in Africa called on other senior members of the Syrian government and military to break with President Bashar Assad.
The Jordanian government and the Syrian rebels said Prime Minister Riad Hijab had fled to neighboring Jordan. The rebels said three other ministers also had defected.
The U.S. official spoke on condition of anonymity because the official was not authorized to speak publicly on the matter. The official said the U.S. is trying to confirm reports of the defections.
Clinton will stop in Turkey for talks on Syria on Saturday.


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Another week of landscape links from around the world
The Big Task of Managing Nature at New York's Central Park | Charles A. Birnbaum | The Cultural Landscape Foundation
"Central Park faces unprecedented use, along with changing climatic conditions and an onslaught of severe weather events. Additionally, increasing knowledge and proven notions about ecological restoration have added a new dimension to this century-and-a-half long conversation about how we interact with our environment and manage our idealized version of nature."
Green walls 'need building code' to reduce fire hazard
"A SYDNEY landscape architect is pushing for green walls to be regulated under building and fire safety codes after he recently saw one go up in flames at a local bar."
Urban Forestry for Symbolizing Eco-City | Md. Zahidur Rahman and Saeed Ahmed Siddiquee | Blitz
"Currently, unplanned urbanization resulted ecological imbalances in the city. FAO (2008) pointed out that Dhaka city has 21.57% open space where city parks belong to 0.89% and 0.02% for urban forest, garden for 0.90% and 12.12% for agriculture to meets the ecological balance of the city dwellers."
African Ministers Adopt Programmes to Boost Sustainable Development, Eye Key Role in Post-Rio+20 Landscape | UNEP
What architects do doesn't count | Jody Brown | Coffee with an Architect
"Because we don't design the destination. We design the path."
Fire-Resistant Plant List for the California Supplemental Exam | CSE for Landscape Architects
"These plants will eventually burn if the fire conditions are hot and dry enough, but they resist ignition better than many other species."
Exploring the Upper West Side's Riverside Park South | Curbed NY
"Riverside Park South offers up one of the Manhattan's best opportunities to consider the city's past as an industrial hub while considering the future of its waterfront. "
IMAGE CREDIT: Flickr User Ed Yourdon


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New York, New York
Did you know that here in New York an estimated 2 million people, or 12.3% of the population now have diabetes. Of these, 517,000 of them have diabetes and simply do not know it. In addition, 5,412,000 people in New York or a staggering 36.2% of the population, have prediabetes. Every year an estimated 66,000 people in New York are diagnosed with diabetes. It is our mission to educate those living with diabetes and prediabetes as well as to prevent more New Yorkers from getting diabetes.
The impact of diabetes hits Latino/Hispanic and African American New Yorkers even harder. Of those diagnosed with diabetes 28% are Latinos/Hispanics in the New York City market, and 31% are African Americans. In New York City during 2007, 22 African Americans and 23 Latinos/Hispanics of every 100,000 died from diabetes.
That is why the American Diabetes Association's New York office is so committed to educating the public about how to stop diabetes and support those living with the disease.
We are here to help!
Greater New York Tour de CureWantagh, New York
The Greater New York Tour de Cure is an event for all riders, walkers, and runners in New York and Long Island to pool our resources, raise more funding to Stop Diabetes, further the mission and awareness of the American Diabetes Association, and build a community of supporters of the Association right here in the Greater New York area. New this year! An Xtreme Obstacle Course - a mobile ninja challenge that will test your strength, balance, speed and agility!
Program Info
The American Diabetes Association's Greater New York office serve the community with a variety of FREE programs, workshops and awareness campaigns for people living with diabetes, their friends and family.
Life isn't fair for people with diabetes. First, there is the simple fact of coping with a chronic illness. Second, there are the barriers that prevent people with diabetes from enjoying the same opportunities as the rest of the population. Our Advocacy efforts work to bring down the barriers and fund research to Stop Diabetes®.
Por tu familia
Our flagship Latino Intiatives program, Por tu familia ("for your family" in English) includes publications on topics ranging from cooking with Latin flair, to be being more physically active, to maintaining a healthy weight as well as a variety of community-based events, workshops and activities which focus on learning more about diabetes and the importance of making healthy food choices and being physically active on a regular basis. To learn more and get your community involved, contact Helene Velazquez at email@example.com.
Live Empowered
Focusing on the African American community, Live Empowered offers a number of programs including the faith-based Project POWER and Choose to Live, a diabetes awareness toolkit targeting African American women, ages of 35-55. Community-based activities and workshops are also available. To learn more and get your community involved, contact Daphney Quinones at email@example.com.
Older Adults
Our Senior Signature Series targets older adults across the nation. Our goals are to address the needs of this group of constituents and increase the level of awareness about the high prevalence of diabetes and prediabetes among our seniors. To schedule the series or learn more, contact Daphney Quinones at email@example.com.
Volunteer With Us
Your involvement as an American Diabetes Association volunteer—whether on a local or national level—will help improve lives of everyone impacted by diabetes, maybe even someone close to you. There are many ways for you to get involved—a little time can have a big impact.


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Studies in Porphyria III: Heme and Tin Mesoporphyrin in Acute Porphyrias
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
OBJECTIVES: I. Compare the efficacy of heme arginate, singly or in combination with tin mesoporphyrin, in lowering porphyrin precursors in patients with asymptomatic acute intermittent porphyria.
II. Evaluate and compare the safety and tolerability of these treatment regimens in this patient population.
|Drug: heme arginate Drug: tin mesoporphyrin
|Phase 2
|Study Type:
|Study Design:
|Primary Purpose: Treatment
|Estimated Enrollment:
|Study Start Date:
|September 1997
PROTOCOL OUTLINE: This is an unblinded, dose ranging study. Patients receive heme arginate alone or in combination with tin mesoporphyrin.
Patients receive tin mesoporphyrin IV as a single dose. Heme arginate is administered as a single intravenous infusion.
Patients are entered in cohorts of 4. Subsequent cohorts of 4 patients each receive escalating doses of tin mesoporphyrin in combination with 1 of 2 different dosages of heme arginate. Subjects must maintain a constant diet.
Patients experiencing adverse reactions are followed as clinically indicated.
|Ages Eligible for Study:
|18 Years and older (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
--Disease Characteristics--
- Documented acute intermittent porphyria in remission for at least 1 month
- Increased excretion of porphyrin precursors
- Absence of neurovisceral symptoms due to porphyria for at least 1 month
--Prior/Concurrent Therapy--
- At least 1 month since prior heme preparation therapy
- Concurrent medication for coexisting condition is allowed, as long as dose and pattern of administration is held constant during study
--Patient Characteristics--
- Renal: Urinary porphobilinogen excretion of at least 20 mg every 24 hours
- Other: Not pregnant Fertile female patients must use effective contraception during and at least 6 months before study At least 1 month since any symptoms of disease No concurrent acute hemorrhagic disorder such as: Gastrointestinal bleeding Intracerebral hemorrhage No known hypersensitivity to heme arginate, tin mesoporphyrin, another heme preparation, or related heme analogue No other condition that may increase risk to patient
Please refer to this study by its ClinicalTrials.gov identifier: NCT00004396
|United States, New York
|Rockefeller University Hospital
|New York, New York, United States, 10021-6399
|United States, Texas
|University of Texas Medical Branch
|Galveston, Texas, United States, 77555-0209
|Study Chair:
|Karl Elmo Anderson
|University of Texas
|ClinicalTrials.gov Identifier:
|NCT00004396 History of Changes
|Other Study ID Numbers:
|Study First Received:
|October 18, 1999
|Last Updated:
|June 23, 2005
Keywords provided by National Center for Research Resources (NCRR):
inborn errors of metabolism
rare disease
Additional relevant MeSH terms:
Porphyria, Erythropoietic
Metabolic Diseases
Skin Diseases, Genetic
Genetic Diseases, Inborn
Skin Diseases
Tin mesoporphyrin
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
ClinicalTrials.gov processed this record on August 22, 2017


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Go to NorCal and explore. Between November and February the waves are quality at least 6 days out of 10. SoCal is chock full of self-involved kooks who think the world revolves around them. Honestly, a lot of the locals are ****s who have no clue what it's like to be a wave-starved east coaster. I am not saying "don't go", but fair warning. Of course there are lots of cool people as well, but from my experience the split is 50/50 or worse at most breaks from LA and south. I lived up North for a year (won't be naming any spots on this thread) and surfed alone all the time. It just takes a little effort and some nerves to not get spooked by the masses of sea life all around you. Honestly, there were days when I sat in the lineup hoping somebody would paddle out just to kill the loneliness.
Results 1 to 10 of 26
Thread: Unexplored California?
Threaded View
Aug 27, 2012, 01:23 PM #16


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Hey there, time traveller!
This article was published 19/2/2013 (1646 days ago), so information in it may no longer be current.
Celebrity trainer Jillian Michaels will be visiting Winnipeg this April as part of her Canadian tour.
Michaels, known mostly from her role on the TV show The Biggest Loser, will be speaking at the Centennial Concert Hall on Thursday, April 4. The event is part of her Maximize your Life tour.
Tickets will go on sale Feb. 25.


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Wine A to Z
Yalumba Eden Valley Viognier 2015
Yalumba Eden Valley Viognier is a apricot nectar, lifted honeysuckle and orange oil-tinted apricot bomb.
Yalumba 'The Scribbler' Cabernet Sauvignon Shiraz 2012
This rich, energetic red testifies to just how smart the Yalumba crew are at making wine.
Villa Wolf Pinot Noir 2015A vibrant, flavoursome Pinot Noir from Germany's Pfalz region. Made under the guidance of the esteemed Ernst Loosen, it's a classy treat.
Villa Wolf Dry Riesling 2015Made by Pfalz master Dr Loosen, Villa Wolf is crisp and balanced, with delicate flavours of peach, wrapped up in a cool mineral cloak.
Yalumba 'The Signature' Cabernet Shiraz 2012
'The Signature' is filled with bold dark fruit and mocha laden flavours.
Marvelous Blue 2015
Blueberry, cassis, tobacco, cedar. Ah one, two, ah one two three four..
Marvelous Red 2015
Cherry, rose petals and chalk. Music to the tongue!
Marvelous Yellow 2016
Chalky bass notes, trills of lychee, honeysuckle and papaya... Anyone fancy a dance?
We understand that around 500 bottles of wine is a lot to browse in one sitting so you can use the filters on the left to help refine your search, by country, grape, characteristic or vintage.If you're looking for Champagne or Sparkling wine, click here to see our range of the fizzy stuff, while our Ports and Sherries can be found in our range of Fortified Wine. Happy browsing!
Graacher Himmelreich Riesling Kabinett 2015£15.75
In stockRiesling (100%)Oak:3Light Full bodied4Dry Sweet


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HE was named after a man who gained football immortality by winning the Champions League for Manchester United against Bayern Munich.
Now little Ole Gunnar Underhay, nine, followed in the footsteps of the legendary Ole Gunnar Solskjaer by taking to the pitch as United lined up the German giants again.
The Radipole School pupil was chosen as a mascot for the Champions League clash between United and Bayern in a re-match of the 1999 final in which Solskjaer scored the winning goal.
You can see a video of the Weymouth youngster walking out on to the pitch here:
Ole Gunnar told the Echo that walking out on to the pitch was an 'unbelievable experience'.
He said: "I was so excited and my friends were really jealous, I still can't really believe it.
"It was something I will never forget, and it was great going there with my dad."
Ole Gunnar's dad Martin was a striker for Weymouth FC and was at Old Trafford on Tuesday night to watch his son stride out with Bayern's left back David Alaba.
The youngster plays for Weymouth FC Youth Under-10s and will now be dreaming of emulating his Old Trafford heroes.
Martin, who is now a football referee and lives in Lodmoor, said: "He was chosen to walk out with the Munich players and be with the players on the Old Trafford pitch as the famous Champions League music rang out.
"It was amazing with the enormous noise and electric atmosphere inside the 75,000 sell out stadium."
Ole Gunnar's mum, Sarah Underhay, said she was so excited seeing her son walk out on the pitch while watching it on TV at home with three-year-old son Harry.
She added: "As soon as we got the call about it and told Ole Gunnar he hasn't been able to sleep because he has been so thrilled.
"It was a truly once-in-a-lifetime experience that will stay with Ole Gunnar forever and had Martin and I bursting with pride."


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BLACKBURN with Darwen's GLOW service is being relaunched over the coming weeks.
The Guidance for Living Over Winter (GLOW) scheme, backed by Blackburn with Darwen Council, NHS and voluntary organisations, will offers winter housing advice to vulnerable people and can get them extra help.
Help available includes, an assessment for and access to affordable warmth interventions, emergency help with heating, review of benefits entitlement, a handyperson to help keep properties, wind, weathertight and safe, assessment and support to prevent falls and ensure home safety, a personal crisis contingency plan and access to other assistance The GLOW service is being relaunched over the coming weeks.
Councillor Mohammed Khan, Executive Member for Health and Adult Social Care, said: "The GLOW scheme is incredibly important for many people in the winter months. We can check that they are getting all the benefits they are entitled to and that they have the right heating, insulation and fire safety measures."


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Why You Should Bring Donuts to a Salary Negotiation (and 3 Other Negotiating Techniques That Work)
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This Is the Worst Salary Negotiation Advice Ever, According to an Expert
JD Hancock/Flickr Recently, PayScale spoke with Dawn Rosenberg McKay, a career development specialist, to get her take on the worst career advice ever...