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327 Shaker Hill RoadHenniker, NH 03242MLS Number 4618209
- Price: $925,000The price has recently decreased
- Est. Mortgage of $/month
- 183 Days on Market
|Down Payment
|Interest Rate
Est. Mortgage: $/month
Federal 30-year interest rate: 4.03% last updated on 2017-07-13
This product uses the FRED® API but is not endorsed or certified by the Federal Reserve Bank of St. Louis.
- 10.72Acreage
- RRZoning
- 300Road Frontage
Don't miss out on this one of a kind reproduction colonial beauty that sits high on almost 11 acres of open fields with spectacular westerly views. No expense was spared in the construction of this fabulous home. Careful attention was paid to absolutely every detail to create an authentic look and feel of an earlier era. But don't be fooled, this home features state of the art heating & cooling, air filtration, fire suppression system, & more. Luxurious Crown Point cabinetry adorns the kitchen and large soapstone counters provides plenty of work space. The master suite offers a walk-in closet w/2nd floor laundry, master bath w/radiant flooring, clawfoot soaking tub and more. Need more room? The third floor is ready to be finished to add an additional 880 sq ft. Enjoy long summer days around the heated pool & spa, or cook out on the patio. SKIERS TAKE NOTE: Pat's Peak Ski Area view and the mountain is less than a 10 minute drive from home. Featured in many publications including Yankee, BH&G and most recently 'Early Homes' Magazine.
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South Burlington VT, 05403
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Basic Information
- LM MST WGARAttached
- BloggingNo
- List Price$925,000
- Virtual TourClick Here
- SeasonalNo
- Bedrooms3
- Bathroom3
- Total Baths3
- MLS Number4618209
- Room 1 TypeKitchen
- Room 1 Level1
- Room 1 Dimensions16x24
- Room 2 TypeDining Room
- Room 2 Level1
- Room 2 Dimensions14x16
- Room 3 TypeLiving Room
- Room 3 Level1
- Room 3 Dimensions15x30
- Room 4 TypeFamily Room
- Room 4 Level1
- Room 4 Dimensions18x20
- Room 5 TypeMaster Bedroom
- Room 5 Level2
- Room 5 Dimensions15x21
- Room 6 TypeBedroom
- Room 6 Level2
- Room 6 Dimensions13x14
- Room 7 TypeBedroom
- Room 7 Level2
- Room 7 Dimensions11x16
- Room 8 TypeOther
- Room 8 Level2
- Room 8 Dimensions22x34
- Interior FeaturesAttic, Cathedral Ceiling, Ceiling Fan, Dining Area, Fireplace - Wood, Fireplaces - 3+, In-Law/Accessory Dwelling, Kitchen Island, Laundry Hook-ups, Master BR w/ BA, Natural Light, Surround Sound Wiring, Walk-in Closet, Window Treatment, Laundry - 2nd Floor
- StreetShaker Hill
- Building Number327
- TownHenniker
- Zip03242
- Flood Zone Y/NUnknown
- CountyMerrimack
- DistrictHenniker Sch District SAU #24
- High SchoolJohn Stark Regional HS
- Map1-701
- StateNH
- Acreage10.72
- Lot DescriptionField/Pasture, View
- ZoningRR
- Lot2
- DrivewayGravel
- RoadsGravel, Public
- Road Frontage300
- Property TypeSingle Family
- Electric200 Amp, Circuit Breaker(s), Generator, Underground
- Heat FuelGas - LP/Bottle
- Heat SystemAir to Air Heat Exchanger, Baseboard, Multi Zone, Radiant Floor
- Sewer1500+ Gallon, Concrete, Leach Field, Private, Septic
- WaterDrilled Well, Private
- Assessment #769650
- Assessment Year2016
- Tax Yr2016
- Tax ReductionNo
- Surveyed Y/NUnknown
- Docs AvailableDeed, Tax Map
- AVMNo
- PossessionAt Closing
- Taxes$24,221
- Year Built2006
- Full Baths3
- FloorsHardwood, Slate/Stone
- Stories2
- Water HeaterTank
- Total Rooms9
- AG Sqft1312
- APX Unfin Below Grade1844
- BasementConcrete Floor, Full, Insulated, Stairs - Interior
- FoundationConcrete
- Property StyleColonial
- Building ConstructionWood Frame
- ConstructionExisting
- Square Feet4078
- RoofShingle - Architectural
- ExteriorCedar, Clapboard, Wood
- Exterior FeaturesBalcony, Hot Tub, Outbuilding, Patio, Pool - In Ground, Shed
- GarageAuto Open, Direct Entry, Heated
- Parking Spaces3
- AmenitiesCentral Vacuum, Humidifier, Irrigation System, Satellite, Satellite Dish, Security System, Smoke Detectr-Hard Wired, Sprinkler System
- Parking DescriptionParking Spaces 6+, RV Accessible
- Broker NameMill City Realty
- Agent NameDuPaul
- Date Listed02/16/2017
- StatusACT
- Foot Print Dimirreg
- Page1731
- Delayed ShowingsNo
- Number of Photos32
- View Count7
5 Bedrooms tmListingFieldArray . 4 Bathroom 4240 Square Feet 141.43 Acreage Year Built in 1784.
The Ocean Born Mary House of 1784. One of the most lovingly preserved & maintained example of Georgian architecture in New Eng. with 141+ ac. of woodlands, fields, trails, & seasonal streams. Of museum quality, the comfortable home has many original features as wide pine flooring, 6 fireplaces incl. the spectacular "keeping room" frpl.& beehive oven w/granite hearth, wood windows w/18th C. glass, gunstock corners, & Indian shutters. A remodeled period style kitchen w/views of the far hills from the breakfast room & custom cabinets, slate counter tops, & historic beams. The 1st flr has a tavern room w/2nd cooking frpl & beehive oven, and living & dining rooms. NW views from elevated screen porch. 2nd flr boasts 5 bedrms incl. a 3 room master suite w/working firpl, ample closets, remodeled bath & office or media room. Full attic. New roof (9/16), newer furnaces (1 wood) and many systems updated. See "Improvements Addendum." Delight yourself by being the next steward of this fine home. More
5 Bedrooms tmListingFieldArray . 4 Bathroom 3546 Square Feet 275 Acreage Year Built in 1900.
Classic New Hampshire farm with 265 acres of productive hayfields and woodlands in the vibrant college community of Henniker. Beautiful, private setting with views and frontage on two roads. The c.1800's farmhouse includes many original details such as wide-pine floors, 4 fireplaces, two beehive ovens and has great potential. There are several outbuildings on the property for livestock, horses etc., as well as a camp on the far side of the property. Located just outside the village of Henniker, and an easy commute to Concord and Boston. More
Copyright 2017 Northern New England Real Estate Network, Inc. All rights reserved. This information is deemed reliable but not guaranteed. The data relating to real estate for sale on this web site comes in part from the IDX Program of NEREN. Subject to errors, omissions, prior sale, change or withdrawal without notice. This web site is updated daily.


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Men: Standard size: 8.5"
Baby: Standard size: 5.5"
Please specify if different sizing is needed in the 'Special Instructions' box upon checkout
We would be happy to offer a full refund (minus any shipping costs) if you are unhappy with your purchase for any reason. All returns must be made within 7 days of purchase date (no exceptions) and must be unaltered and in original packaging. We want you to love what you wear and shop from us again, which is why we offer this generous return policy! 'No strings attached' and if for any reason a bracelet becomes unstrung, please send it back to us and we would be happy to fix it for you at no charge.
Please also keep in mind that each bracelet set is handmade for you at the time of purchase so no exchanges please.
The Mercedes Limited Edition set is featured in rose gold and includes black obsidian, faceted grey jade, pink opals and fresh water pearls. Set comes with rose gold, copper and sterling silver hardware. Comes in standard size 7.
Customizable upon request.


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|Property type
|Minimum Stay
|3 nights
Beautiful architecture with two story glass wall, passive solar with ceiling fans fronting the Upper Klamath Lake. We have open water year round in front of the house bringing in the birds for up close viewing. Take in a stunning sunset lake view as you relax and enjoy a glass of wine in the living room or master suite.
Plant & flower filled Atrium.
Large open kitchen with cherry wood, granite & Saltillo tile.
Spacious master suite with Cal King bed, whirlpool spa & shower.
Cozy gas fireplace. Immaculate throughout.
Outdoor deck with premier wildlife and bird viewing.
Complimentary kayaks, canoe and rowboat.
Located across from the Klamath Basin Birding Trail @ Putnam's Point #29.
We have many complimentary brochures.
Wi Fi. Resource library of art, history, geography & birding.
Minutes to South Portal Visitor Center on historic Main Street Downtown with restaurants & shopping. Walk Wingwatchers Trail. Go hiking or biking along the Link River Trail for premier birding. Public golf & swimming & Historic Interpretive Walks available.
Host to the BBC Natural History Unit filming the 'Dancing Grebes' for the 2010 'Life' Discovery Special , the NHK Team filming for Japanese Public Television Nature Series, National Geographic authors, birding experts and travel writers.
World famous Crater Lake National Park, Lava Beds National Monument and The Ashland Shakespeare Theater are a perfect half day excursion.
Keywords: Waterfront House, Private Dock, Fishing, Bird watching
We have lived in the Klamath Basin since 1991. We have been actively involved in natural resource issues, construction and guide and outfitting. Most recently we finalized a 7 year project, 'Creating A Sense of Arrival' with the remodel of a Visitor Center for the City of Klamath Falls to showcase our beautiful downtown, trail system and waterfront area. This 'One Stop' location offers visitors and locals a place to get information about our area from the Chamber of Commerce and Discover Klamath. Other tenants include Klamath County Economic Development, the Hombuilders Association, Watershed Partnership and Ducks Unlimited.
We are recipients of the City of Klamath Falls 'Green Pelican Award' and US Fish & Wildlife Wetlands Conservation Award.
Jim & Stephanie Carpenter purchased this house in 1996
We built our home in this very special location because it is on the waterfront and centrally located.
This property is unique due to it's up close and personal all season watchable bird and wildlife, which can be viewed from the comfort of your living room or outdoors on the deck. Boating, birding and fishing are a just a few steps away.
Downtown Klamath Falls is only 5 minutes and the airport a mere 15 minutes.
If you like to hike or bike the Link River Trailhead can be seen from the living room. This Trail takes you to historic Main Street where you can enjoy lunch and visit a museum.
The view was beautiful, way better looking than my handwriting. We saw so many birds I think I should list them.
I saw a Great Egret, Double Crested Cormorant, Black Crowned Night Heron, American White Pelican, Stellars Jay, Clarks & Western Grebes, Clarks Nuthatcher, Osprey, Sparrows, Finches, Black Headed Grossbeak, Redwing Blackbird, and Morning Doves. Thanks for the warm kindness, hospitality, and information. I forgot to mention the Tree Swallows, Goldfinches, Gulls, Geese & Robins.
It was so wonderful to have a comfortable home for bird watching...I found myself so involved with grebe watching, from early am to early pm, that I really didn't want to go anywhere else and I didn't the majority of my stay....I definitely will come again and hopefully plan a trip each year during this time or a little later to see the grebes, white pelicans, other waterfowl and the many songbirds I enjoyed on the trees next to the patio...there were so many species!! I recommend this spot for anyone who wants to watch the grebes mating during this time of the year as I observed over 45 pair demonstrating their beautiful ritual of mating, or at least looking for a mate!! This was on my "bucket list", watching the grebes, and this is the most perfect spot....thanks for a wonderful time....lynda steiner
We loved to stay in this property. House is spacious and both bedrooms are big. It is next to lake. View is wonderful from inside of the house. We watched birds from sitting inside in the house. Although we could not open the door as there are lot of mosquitos. Good collection of books. I recommend living in this property.
The view is nice out the windows, but the house is not as advertised...Definitely not "World Class Eco Gem".
There is no air conditioning as advertised, and when we called to ask about this, the owner stated that it was a "miss print" on the website and if you clicked on the air conditioning word (not link) it stated that there was no air conditioning. Suggestion -be honest and state there is no air conditioning. This is important especially when temperatures can be in the 90's to over 100 degrees in the summer.
The boats advertised are not in good shape and when we asked for assistance the owner stated we needed to call her nephew. We called and and texted her nephew, and the nephew did not call us back until late the following day. He said he would stop by, but never did. We were not able to use any of the boats.
The next door neighbor's dogs (which are close) barked at us constantly when we sat out on the deck.
Small black ants in the kitchen.
The bathtub upstairs was filthy and full of bugs.
Got a text on our last day from the owner that stated, "My housekeeper is coming at 11 to clean. We have guest arriving at four so she has a short time frame." Basically "get out" so that the housekeeper can come to clean for the next guests. 11:00 AM was check out time and we were out before then.
Owners are not friendly or helpful.
We had a fabulous time at this home in Klamath Falls. The view was amazing and the house was awesome...the huge windows added light and made it easy to enjoy the outside view. The home was clean and well equipped especially in the kitchen. Charming with plenty of room. The beds were very comfortable and the bedrooms were roomy with lots of storage.
Outside we held an afternoon party for our daughter graduating from college. Lots of grassy area to put out tables and chairs and the weather was perfect. Lots of shade as well.
The view of the lake put it over the top. All the guests loved it and enjoyed taking the kayaks and canoe out. In the evening we all gathered around the fire pit. Very relaxing!
We were also able to bring our small dog and she had a great time running around the yard.
Stephanie was great to work with and made it very easy to communicate with us and answer our questions and meet our needs. Thank you for sharing your home!
This was our second trip to this property in Klamath Falls. It is a beautiful home in a beautiful location. We are birdwatchers who have come here to watch the grebes performing their courtship behaviors. It is a perfect site. You can sit on the deck and watch them running across the water. I highly recommend this home and this experience!
My husband and I had a wonderful time staying at the Carpenter's rental home. It was so relaxing and peaceful, and we thoroughly enjoyed the grebe and other bird activity on the lake. The house is beautiful and made our experience fantastic!
|Cleaning Fee
|Pet Fee
|Damage Insurance
Check In is 4 PM & Check Out is 11 AM


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A Roomba Review + WIN! An iRobot Braava 380t Floor Mopping Robot
It's a Boy! Our Gender Reveal Party
Getting Ready for Baby: How We Improved Our House
Why I Wear Secondhand Clothes
Old Stone Cottage, Contemporary Addition
Storefront: Hero & Leander
The Old Wool Warehouse
Merry Christmas House Nerds!
Obsessed With: Villa Kula
The Old Bayswater House


text: Whether you want to learn acoustic, electric or bass guitar, we have an excellent team of guitar instruction experts whose musical interests and training range from classical to metal and everything in between. Guitar lessons at KLM are enhanced by the opportunity to jam with other musicians in a rock band setting or learn to play guitar as a soloist. The best way to learn guitar is to take private guitar lessons and of course practice! At KLM Music we have guitar lessons for kids, adults and everyone in between. Fill out the form below and you will be on your way to the KLM Guitar School in no time at all.


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Daily Mail
Atletico Madrid 2-0 Real Madrid: Raul Garcia and Jose Gimenez strike to gain …
Daily Mail
They came for the Fernando Torres dream debut, they gladly settled for the Sergio Ramos nightmare. The Atletico Madrid striker did not score on his return to the Vicente Calderon but a senseless foul in the area from Ramos gave Raul Garcia the perfect …
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Atlético Madrid v Real Madrid: Copa del Rey – as it happenedThe Guardian
Atletico Madrid 2-0 Real Madrid: Gimenez header puts Blancos on the brinkGoal.com
Eurosport -Mirror.co.uk
all 1,268 news articles >>
Source: madrid – Google News
Sharing information is key – Madrid News in UK. Social Commerce and Social Media Management playing a big part. Suaju Ltd


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Dr. Eelkema is knowledgeable, friendly, and genuinely cares about me as a patient. Every time I go back to see him it is a positive experience.
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Drew my next tattoo its my Indian name. White moon feather
Somedays I am perfectly happy drawing all day. This is for Gabriella. #wolf…


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The use of fluorescence imaging has become widespread in mouse models of cancer and has begun to make an impact in the clinical care of patients.1,2 Fluorescently tagged tissues of interest allow for easy detection and demarcation from other structures in both living and fixed tissues. In living tissue, this allows for differential imaging of cells or molecules without disrupting other biological processes and also for real-time imaging.1
Fluorescence-guided surgery (FGS) using a variety of techniques has been evaluated in mouse models and humans and been shown to facilitate evaluation of critical structures and resection of tumors.220.127.116.11.8.9.10.–11 In an effort to bring FGS to the clinic, we have performed FGS in orthotopic mouse models of pancreatic and colon cancers, labeled with tumor-specific monoclonal mouse antibodies conjugated to Alexa Fluor 488, a green fluorophore.12,13 In subsequent studies, minimally invasive fluorescence laparoscopy was used to image orthotopic pancreatic tumors in mice labeled with fluorophore-conjugated monoclonal mouse antibodies to CEA.14,15
However, there remains uncertainty regarding the choice of the appropriate fluorophore for optimal imaging of pancreatic cancer with fluorophore-conjugated antibodies. We hypothesized that there would be a hierarchy in the ability of a set of visible and near-infrared fluorophores, conjugated to a chimeric anti-CEA antibody, to detect pancreatic tumors with respect to depth of imaging, resolution, tumor-to-background ratio (TBR), photobleaching, and hemoglobin quenching. Therefore, the aim of this study was to compare several commercially available fluorophores of different wavelengths, conjugated to a novel clinically relevant chimeric anti-CEA antibody, to determine the optimal dyes for imaging pancreatic cancer growing orthotopically in nude mice.
The chimeric anti-CEA antibody used in the present study has a human Fc portion and a mouse Fab portion. As nonhuman proteins, mouse antibodies tend to evoke an immune reaction if administered to humans. The chimerization process involves engineering the replacement of segments of the antibody molecule. Since the chimeric anti-CEA antibody has a human Fc domain, it thereby eliminates most of the potentially immunogenic portions of the antibody, without altering its specificity for the intended target.
The present studies were performed in an orthotopic model of pancreatic cancer and included the determination of the dyes' ability to penetrate skin, peritoneum, and liver. These are all clinically relevant concerns when considering the appropriate choice of fluorophore for tumor detection.
Materials and Methods
Cell Culture
The human pancreatic cancer cell-line BxPC-3 was maintained in RPMI-1640 medium supplemented with 10% fetal bovine serum and 2-mM glutamine from Gibco-BRL, Life Technologies, Inc. (Grand Island, New York). All cells were cultured at 37°C in a 5% incubator.
Surgical Orthotopic Implantation
After confluence, BxPC-3 human pancreatic cancer cells () were injected subcutaneously into the flanks of nude mice until tumors grew between 10 and 20 mm in diameter. The tumor was harvested, and tumor fragments were implanted orthotopically in nude mice, as previously described by our laboratory.1617.18.–19
Antibody-Dye Conjugation
Chimeric anti-CEA antibody (Aragen Biosciences, Morgan Hill, California) was conjugated with Alexa Fluor dyes (Life Technologies, Inc.) or DyLight dyes (Thermo Fisher Scientific, Rockford, Illinois) (Table 1) per manufacturer specifications, ensuring a minimum of at least dye:protein ratio. Protein:dye concentrations were confirmed using a NanoDrop Spectrophotometer (Thermo Fisher Scientific, Waltham, Massachusetts).
Animal Care
Athymic nu/nu nude mice (AntiCancer, Inc., San Diego, California), between 4 and 6 weeks of age, were maintained in a barrier facility at AntiCancer, Inc., on high-efficiency particulate air-filtered racks. The animals were fed with autoclaved laboratory rodent diet (Teckland LM-485; Western Research Products, Orange, California). All surgical procedures and imaging were performed with the animals anesthetized by intramuscular injection of 0.02 mL of a solution of 50% ketamine, 38% xylazine, and 12% acepromazine maleate. When inhalational anesthesia was required, 99% isoflurane and 100% oxygen were delivered via a vaporizer. All animal studies were conducted in accordance with the principles and procedures outlined in the NIH Guide for the Care and Use of Animals under PHS licence number A3873-1.
Experimental Protocol
After surgical orthotopic implantation of the human pancreatic cancer cell-line BxPC-3, tumors were allowed to grow for 7 days, after which the mice were injected with the antibody-dye conjugate into the retro-orbital vein (Fig. 1). Antibody amounts were maintained between 50 and 75 μg, while ensuring 1.25-μmol dye was delivered with each injection. Whole body imaging was subsequently performed using the OV100 Small Animal Imaging System (Olympus, Tokyo, Japan) after 24 h. If tumors were detectable on whole body imaging, the animal was sacrificed, and tumor characteristics including size, fluorescence intensity, weight, and depth were determined. For mice that did not demonstrate tumors on initial imaging, the tumors were allowed to grow for another 7 days, and the process repeated until the tumor was visible, at which point mice were sacrificed and tumors analyzed as above.
Tissue Penetration
Prelabeled tumor fragments, with either Alexa Fluor or DyLight dye–antibody conjugate, were cut into fragments of 0.5, 1, and 2 mm. Three fragments of each size were then placed on a petri dish and imaged. After confirming fluorescence labeling, the fragments were covered with a layer of skin obtained from a nude mouse and imaged to evaluate skin penetration. The tumor and peritoneum were then covered with the abdominal wall obtained from a nude mouse and subsequently imaged to evaluate for penetration through the skin and the abdominal wall.
The 488, 550, 650, and the 755 groups of dye conjugates were titrated to equal fluorescence intensity in three consecutive wells on a 64-well plate. Each well plate contained 200 μL. The conjugates were then continuously exposed to a 60-W halogen light bulb to mimic operating room settings for up to 48 h. For the 488 group, fluorescein was also added as a control. The dye conjugates were imaged at the 1-, 2-, 4-, 6-, 8-, 24- and 48-h time points and intensities were recorded.
Hemoglobin Quenching
DyLight 488, 550, 650, and 755 dye conjugates were titrated to approximately equal fluorescence intensity on three consecutive wells on a 64-well plate. Each well contained 200 μL. Then 15 μL mouse whole blood was then sequentially added to each well, after which the wells were imaged and the fluorescence was recorded. Tumor fragments, prelabeled with each of the dyes, were then covered with a liver fragment, modeled to simulate penetration through a hemoglobin-dense organ. Imaging was performed with the OV100 to assess for penetration through the liver tissue.
Animal Imaging
Mice were imaged using the OV100, containing an MT-20 light source (Olympus Biosystems, Planegg, Germany) and DP70 CCD camera (Olympus Corp.). The OV100 was used due to its unique ability to accomplish high-fidelity fluorescence imaging with variable magnification capabilities that allow for imaging of not only the whole animal, but also the subcellular level.20 The instrument incorporates a unique combination of high numerical aperture and long working distance. Four individually optimized objective lenses, parcentered and parfocal, provide a 105-fold magnification range for seamless imaging of the entire body down to the subcellular level without disturbing the animal. In addition, openings on the machine allow for delivery of inhalational anesthesia to the animal without allowing entry of outside light. This allows for capturing high-quality in vivo images with minimal morbidity to the animal by avoiding anesthetic injections. All images were analyzed using Image-J (National Institutes of Health, Bethesda, Maryland) and were processed with the use of Photoshop elements-11 (Adobe Systems Inc., San Jose, California).
Frozen Section Analysis
Twenty-four hours after injection of 1.25 μmol of anti-CEA conjugated to DyLight 650, the orthotopic tumor was harvested. The tumor was placed in OCT compound and subsequently dipped into liquid nitrogen. Once the tumor was frozen, it was placed on a microtome, sliced into 5-μm sections, placed on a glass slide, and immediately dipped in 95% ethanol for fixation. Alternate slides were stained with hematoxylin & eosin (H&E) or 4′,6-diamidino-2-phenylindole for fluorescence imaging. Fluorescence and bright-field microscopy were performed with the Biorevo BZ-9000 microscope (Keyence Corp., Itasca, Illinois).
Statistical Analysis
All statistical analyses were performed using SPSS software version 21 (IBM, Armonk, New York). For pairwise comparisons between groups within the wavelengths, quantitative variables were compared with the Student's t-test and confirmed with the Wilcoxon rank-sum test. A -value of was considered significant. The 95% confidence intervals obtained on analysis of the data were configured into all the error bars of the appropriate figures and graphs. Multiple groups () were initially compared with one-way analysis of variance (ANOVA), and if a difference was found, pairs of interest were further compared with the Student's t-test. For tumor size versus intensity modeling, the following values were obtained when a quadratic function plot was used for regression analysis: DyLight 488: 0.32; DyLight 550: 0.34; DyLight 650: 0.26; and DyLight 755: 0.41.
Fluorescence Intensity of Dye-Antibody Conjugates
Mice with orthotopic BxPC-3 pancreatic cancers were treated with various anti-CEA antibody-dye conjugates and then imaged 24 h later with the OV100 (Fig. 1). Within the 550 and 750 group of dyes, the DyLight dyes were brighter than the corresponding Alexa Fluor dyes (). Alexa Fluor 488 was significantly brighter than DyLight 488 (). There was no significant difference in the 650 group of dyes (). The brightest dye was DyLight 755 (Fig. 2), which was significantly brighter than the next brightest dye, Alexa Fluor 488 (). There was no significant difference on ANOVA analysis between Alexa Fluor 488, DyLight 650, and Alexa Fluor 600 with . DyLight 650 was, however, significantly brighter than Alexa Fluor 750 with . No significant difference was noted between Alexa Fluor 750 and DyLight 488 with , although Alexa Fluor 750 was significantly brighter than DyLight 550 (). DyLight 550 had no significant difference when compared with DyLight 488 () but was significantly brighter than Alexa Fluor 555 with . A summary of the intensities is provided in Fig. 3.
Tumor-to-Background Ratio
The 750 and 650 group of dyes had the highest TBRs (Fig. 4) with DyLight 755 showing the highest ratio of the other dyes (). ANOVA analysis showed no significant difference between the TBRs of DyLight 650, Alexa Fluor 650, and Alexa Fluor 750, all of which were significantly higher than the dye with the next highest ratio DyLight 550 (). The TBR of DyLight 550 was significantly higher than that of Alexa Fluor 555 (). No significant difference was noted between the Alexa Fluor 555 and 488 pair () and between the Alexa Fluor 488 and DyLight 488 pair (). Alexa Fluor 555 had a TBR that was significantly higher than DyLight 488 ()
The longer-wavelength dyes had the most contrast between tumor and background. The most background autofluorescence was noted with the 488 group, allowing for near complete visualization of the background, while little to no background was discernible with the 650 and 750 groups.
Tumor Depth and Size
The ability to detect the smallest and the deepest tumors consistently increased with longer wavelengths [Figs. 5(a) and 5(b)]. The longer wavelength dyes (650 and 750 nm) had the best tissue penetration with the ability to visualize the smallest tumors. In general, DyLight was able to detect smaller and deeper tumors better than Alexa Fluor within each group, except for the 488 group. There was no significant difference in the ability to detect deeper tumors within the 750 and 550 groups ( and 0.2, respectively). There was a significant difference, however, within the 650 and 488 groups. DyLight 650 could detect deeper tumors better than Alexa Fluor 660 (). Alexa Fluor 488 could detect deeper tumors better than DyLight 488 (). Between groups, DyLight 755 could be detected significantly deeper than DyLight 650 () and DyLight 650 could be detected significantly deeper than DyLight 550 (). No significant difference was observed between DyLight 550 and Alexa Fluor 488 ().
Similarly, smaller tumors were detected at longer wavelength with DyLight dyes better than Alexa Fluor dyes, except for the 488 group. Differences within the groups were all significant except for the 650 group (). Within the 750 and 550 groups, DyLight conjugates detected significantly smaller tumors ( and 0.01, respectively). In the 488 group, Alexa Fluor 488 was able to detect significantly smaller tumors (). Between groups, there were significant differences, except between DyLight 550 and 650 (). DyLight 755 was able to detect significantly smaller tumors than DyLight 650 (), and DyLight 550 was able to detect significantly smaller tumors than Alexa Fluor 488 ().
Prelabeled tumor fragments of 0.5, 1, and were imaged, and subsequently a layer of skin and body wall was placed over the fragments. Repeated imaging verified better tissue penetration with the longer wavelength dyes (Fig. 6). With addition of the tissue layers, the smallest of the DyLight 650 and 755 labeled fragments were still visible on imaging but were invisible in the 550 and 488 groups. Within all groups, the DyLight-labeled fragments were visible at greater depths in comparison to the Alexa Fluor dyes. This held true for all the groups except for the 488 group, where there was better tumor visualization with the Alexa Fluor 488-labeled tumor fragments.
Tumor Size and Fluorescence Intensity
In assessing for a correlation between tumor size and fluorescence intensity with a constant dose of antibody-dye conjugate, the fluorescence intensity of all the DyLight dye labeled tumors and the corresponding tumor sizes were measured. In the analysis, the fluorescence intensity was set as the dependent variable and the tumor sizes as an independent variable, thus creating a model for prediction of the expected intensity given a certain tumor size (Fig. 7). Small tumors appeared to have a lower signal intensity, which would then increase to a maximum for an "optimum" tumor size and would again begin to decrease with increasing tumor size. The longer wavelength dyes were not only the brightest, but also maintained their signal intensity over a broader range of tumor sizes when compared with the shorter-wavelength dyes.
Photobleaching was assessed with a 60-W halogen light continuously shone on antibody-dye conjugates for a period of up to 48 h, with serial imaging and analysis of fluorescence intensity. Overall, the DyLight dyes were more photostable than the Alexa Fluor dyes [Figs. 8(a) and 8(b)]. The time point of eight hours was used as a reference point for evaluation, as this would encompass even the lengthiest of most pancreatico-duodenectomies and other oncologic surgeries. At the 8-h time point, there was no significant difference in the percentage of the original intensity in the 488 () and 550 () groups. Alexa Fluor 488 and DyLight 488 retained 96% and 90% of their original intensity, respectively. Both Alex Fluor 488 and DyLight 488 were significantly brighter than FITC, which retained only 45% of its original intensity ( and 0.002, respectively). The 550 group of dyes was the most photostable, retaining approximately 95% of their original intensity for up to 48 h. With the longer-wavelength dyes, however, there was a significant difference between groups. Alexa Fluor 660 lost all of its fluorescence in 1 h. In contrast, by 8 h, DyLight 650 still had 53% of its original fluorescence (). Similarly, in the 750 group, there was a more rapid decline in the fluorescence intensity of Alexa Fluor 750, and by 8-h, Alexa Fluor 750 had no discernible fluorescence DyLight 755 retained 22% of its original fluorescence intensity at 8 h. Overall, DyLight dyes were more photostable than Alexa Fluor.
Hemoglobin Quenching
With the assessment of hemoglobin quenching, a significant difference was noted between the longer and shorter wavelength dyes. Wavelengths of 550 nm or less showed significant quenching of the fluorescence signal upon addition of whole blood. Dyes at 650 nm or greater showed resistance to hemoglobin quenching [Figs. 9(a) and 9(b)]. With serial addition of whole blood, both DyLight 488 and 550 had of their original intensity after 100 μL; while DyLight 650 and 755 had 95% and 89% of their original intensity, respectively. In a related experiment, a thin slice of liver tissue was placed over prelabeled fragments of tumor and imaged to evaluate for tissue penetration. Similarly, the 488 and 550 fragments were not discernible after placing the liver tissue overlay, while all three fragments in the 650 and 750 groups were visible, illustrating the difference in tissue penetration between the longer and shorter wavelength dyes.
Frozen Section Analysis of Surgical Margins
Figure 10 depicts a frozen section of tumor margin prelabeled with an anti-CEA antibody conjugated to DyLight 650 alongside a corresponding H&E-stained slide. The sharp demarcation of tumor versus normal tissue interface on fluorescence imaging allows for more accurate determination of tumor margins.
We have predominantly used FGS as a method to reduce tumor recurrence and to prolong survival in mouse models of pancreatic and other cancers labeled with fluorescent antibodies or proteins.89.–10,1213.14.–15 In this study, we determined the fluorophores that would optimize tumor labeling. The high-fluorescence intensity, lack of anomalous peaks, and high quantum yields of Alexa Fluor and DyLight dyes, compared to dyes with comparable spectra are important features. The findings from this study suggest that DyLight dyes had higher fluorescence intensities and higher TBRs compared with Alexa Fluor dyes, with the exception of the 488 group of dyes.
This study demonstrated that tissue penetration and the ability to identify the smallest and the deepest tumors increased with an increase in wavelength. With the longer-wavelength dyes in the 650 and 750 groups, we were able to identify even submillimeter tumors with noninvasive whole-body imaging. Overall, DyLight 755 had the best tissue penetration and the ability to identify the smallest tumors. The 488 group had the poorest ability to penetrate tissue and required fairly large and superficial tumors prior to identification with whole-body imaging. Similarly, DyLight dyes outperformed Alexa Fluor dyes within each group, with the exception of the 488 group, where Alexa Fluor 488 had better tissue penetration and enabled imaging of smaller and deeper tumors compared with DyLight 488. The chemical bond between the chimeric anti-CEA antibody and the fluorophore is a covalent amide bond for both the Alexa Fluor and DyLight dyes. Therefore, it is likely that the difference between dyes observed is due to lower autofluorescence and higher imaging depth with the longer- compared to the shorter- wavelength dye conjugates.
The hemoglobin molecule has high levels of absorption in the 400- to 600-nm wavelength range. This raised the question as to whether an emitted fluorescence signal within this range would be significantly quenched. The implications would be significant with respect to FGS, vascular imaging, or imaging of any hemoglobin-rich organ, if this were the case. We were able to demonstrate with our hemoglobin quenching assay that the emission of the 488 and 550 dyes was significantly affected when exposed to whole blood or within the vicinity of a hemoglobin-rich organ, such as the liver. Conversely, the 650- and 750-nm dyes maintained a robust signal with the addition of whole blood and showed good penetration through liver tissue.
Photostability is also a very important attribute for any dyes that would be used in surgical procedures, given the likely continuous exposure to white light, or an excitation-specific signal, over multiple hours necessary for the operation. Typically, even the lengthiest of surgical procedures typically lasts less than 8 h.21,22 Both the 488 and 550 dyes were very photostable during this time frame and maintained of the signal at 8 h. With the longer wavelength dyes, the DyLight dyes were significantly more stable than the Alexa Fluor dyes. There was no signal remaining in the longer wavelength Alexa Fluor dyes, while DyLight 650 and 750 maintained 53% and 22% of the fluorescence signal, respectively.
In summary, the longer-wavelength dyes had increased depth of penetration and the ability to detect the smallest tumor deposits and provided the highest TBRs, lower autofluorescence, resistance to hemoglobin quenching, and specificity. The shorter-wavelength dyes were more photostable compared with the longer wavelength dyes. These studies were done in an orthotopic model of pancreatic cancer, which mimics the clinical scenario, and also with a novel chimeric anti-CEA antibody that could be used in clinical trials. To our knowledge, this type of study has not been previously reported. This study showed the unique advantages of each dye for specific cancer imaging, which is important information for future clinical applications such as FGS.
Table 1
Characteristics of fluorescent dyes.
|Mw (g/mol)
|Excitation (nm)
|Emission (nm)
|ε (cm−1 M−1)
|Quantum yield (%)
|Alexa Fluor 488
|DyLight 488
|Alexa Fluor 555
|DyLight 550
|Alexa Fluor 660
|DyLight 650
|Alexa Fluor 750
|DyLight 755
Note: Mw=Molecular weight, ε=extinction coefficient.
Work supported in part by grants from the National Cancer Institute CA142669 and CA132971 (to M.B. and AntiCancer, Inc.).
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The Greater Cincinnati Radio Control Club is presenting the 57th Annual Flying Circus on August 5th and 6th!
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Press release
Belgian fashion and design trends magazine09/06/2014 , VICTOIRE magazine
The weekend magazine supplement of Le Soir puts the spotlight on its favorites, including MYDO®, in support of the project in the framework of its crowdfunding campaign on kisskissbankbank.com
MYDO® innovation in modular furniture09/06/2014 , in DKLIKK
The Belgian fashion and design eMag09/20/2014 , in DKLIKK
DKLIKK is interested in crowdfunding and presents the 3 projects close to its heart including MYDO®. DKLIKK supports our crowdfunding campaign on kisskissbankbank.com
MYDO® is the big winner of the NRJ Startup competition!09/22/2014 , in Le soir
MYDO® wins top prize in the competition following public's overwhelming vote!
Already acclaimed by the NRJ Startup jury, MYDO® proves to be the public's favorite with more than 2,500 votes in 3 weeks. Out of 150 French Belgian projects presented, MYDO® is the jury and the public's number one!
MYDO®, winner of NRJ Startup09/24/2014 , in the Chambre de Commerce et d'Industrie press revue


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iOS 7 – first look disappointment
So Apple announced the iOS 7 update at last night's WWDC opening keynote and I have to say I am seriously disappointed. One of the beautiful things about Apple's interface designs has always been the human element (the leather, paper, wood effects etc) and this new look is just so flat and non-descript it's as…Read More
The return of the curse of the blu-ray player
So my last piece on blu-ray was an admiration for the beauty of hi-def loveliness, coupled with some ranting about being 'forced' *cough* to buy blu-rays over DVDs. I warn you, today's post is just a rant… This is the story of how I ended up accidentally-on-purpose buying myself a brand new Blu-ray home cinema…Read More
The curse of the Blu-ray player
For years I have wanted a blu-ray player and I was lucky enough to get one for my 22nd birthday. Since then, however, I have been put under the Curse of the Blu-ray player, which manifests itself in an inability to purchase DVDs. Don't get my wrong – I'm well aware that one of the…Read More
E-mail: Is it really the end?
I saw in the news yesterday that the head of one of Europe's largest IT services companies is going to ban staff from sending each other emails. According to them, e-mails waste time and are outdated. Instead he wants them to use an instant messaging and a Facebook-style interface. So something far more social, less…Read More


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Need 100 PR5 or above links to my site
Bütçe $100-300 USD
This Project is for Printer ink cartridges website located at [url removed, login to view]
we need 100 PR5 or above links to the [url removed, login to view] links Must be:
* One way non-reciprocal link. No link Exchanges, Linking page must be PR5 or higher.
*All links must be permanent
*All links must be on ink cartridges,office product,computer Hardware,Relevant themed sites.
*Only direct static links will be approved,No dynamic or Automated link [url removed, login to view] Must check that the acquired link is spiderable. we will not pay for links that are hidden,cloaked or redirected in any [url removed, login to view] from FFAs,Linkfarms,and spam websites are not acceptable.
* Links Must be from different ,geographically diverse,Class-C IP Addresses.
Links Must be on pages with 20-40 outgoing links at most.
Proposed linked websites must have been Google crawled and indexed within last 45 days.
Approvel Process (proposed links Must be approved first) you source all proposed link sites and send them to us for approval prior posting.
You will provide all proposed link data in a Excel spreadsheet which will include : proposed Link site URL, site Name, Site Type, Google page Rank, Alexus Traffic Rank, and IP address.
you submit the information to the approved sites.
when links are up and running, you update the original spreadsheet by adding the URL for the inkcoming link and send us the revised spreadsheet.
* Additional link will be needed and will be requested if satisfied with the quaility of your work.
view my PMB and also see my current SEO Achievement at http://seoxponse.bravehost.com/seo-rank.htm , Curently I am working on New SEO Project http://www.flagzilla.com http://www.xponsewebs.com http://www.comsystems Daha fazlası
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I can assure you that we can provide you with the best solution. You can know more about our company if you visit our website http://www.bccomputersltd.com . . We can assure you that we will provide you with the best q Daha fazlası
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Featured property
Featured property
40 Bedrooms Detached House for sale
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Haus are delighted to offer this currently tenanted block of self contained flats with full planning permission for a new modern block containing 40 high quality bedspaces split over…
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Quite simply, the most exquisite penthouse you will find on the market in leeds which occupies the fifth and sixth floors within this grade ii listed development. (contd...)
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The Sustainable Furnishings Council in cooperation with World Wildlife Fund, Rainforest Alliance, Forest Stewardship Council and numerous other leading governmental, environmental, academic and trade organizations, is launching the first cross-disciplinary ECOngress on legal and sustainable wood sourcing in the home furnishings industry. The one-day event takes place Jan. 31, 2010, the day prior to the opening day of the February 2010 Las Vegas Market. The event is geared to inform every point in the supply chain as to the importance of known legal origin and responsible forestry for wood products. Participants will learn about tools, solutions, and issues of vital importance given the impending next phase of Lacey Act declaration requirements that will be effective in April 2010. ECOngress will mark the first time that such a broad array of constituencies has been assembled to address a sustainability concern in home furnishings. Major organizations represented include WWF's Global Forest & Trade Network, UN's Intergovernmental Panel on Climate Change, U.S. Department of Justice, Yale School of Forestry & Environmental Studies, Weyerhaeuser, Savannah College of Art & Design, Century Furniture, Oregon State, Williams-Sonoma, Architectural Digest and a noted ASID-LEED design practitioner. Major environmental organizations World Wildlife Fund, Rainforest Alliance, Forest Stewardship Council and Tropical Forest Trust will also be participating and collaborating in planning for the event. The sixteen speaker panelists feature some of the world's foremost experts and leaders on the issue, including Richard Somerville, a Coordinating Lead Author for the 2007 4th Assessment Report of the Intergovernmental Panel on Climate Change (IPCC) that won the Nobel Peace Prize for its work in synthesizing tens of thousands of documents from credible scientific journals around the world; Linda Kramme, Manager of WWF's Global Forest & Trade Network-North America program; Elinor Colbourn, U.S. Department of Justice on Lacey prosecution; Ben Cashore, professor, Environmental Governance & Political Science, at Yale University's School of Forestry & Environmental Studies; and Christina Nicholson, Director of Sustainable Development for Williams-Sonoma, Inc. "As the third biggest user of wood products, the furniture industry has a responsibility to take a leadership role in legal wood sourcing, and the ECOngress represents a groundbreaking step by bringing together every vital constituency for the very first time to show support, discuss challenges and share ideas," said Jeff Hiller, president of the Sustainable Furnishings Council. "Leadership is taking action while others wonder 'what if.' The goal of the ECOngress is to identify pragmatic solutions that are good for business and the planet." The One Good World ECOngress comes just two months before the enforcement of the U.S. Lacey Act Amendment is extended to furniture. This U.S. policy change follows The Action Plan on Forest Law Enforcement, Governance and Trade of the European Union (EU) encouraging businesses to adopt purchasing policies that exclude illegal timber and promoting sound public procurement policies through voluntary agreements, but the EU has also contemplated regulations to govern the import and trade of these items. A multi-industry conference organized by Rainforest in September 2009 in Shanghai, China was attended by over 300, further confirming the global scale of the legal wood issue. "We have actually passed a point of no return in terms of environmental awareness, and although the future of the supply chain looks complicated to all of us, the ECOngress will help us move forward with a plan for sustainable growth, as opposed to leaving it to chance," said Robert Maricich, World Market Center Las Vegas' president and chief executive officer. "The interest in participating from environmental groups, academia and all parts of the furnishings supply chain has been remarkable for a trade-oriented event, confirming the vital importance of legal wood sourcing, the need for public discussion between all parties and the inspirational ability of responsible citizenship to transcend industry lines in working toward the common good."
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جماع رجال مع نساء This move was similar to that taken by ADV Films several years before with several of the major torrent sites. جماع رجال مع نساء Tongue Sucking - A variation of the French kiss. Funny Car: With aerodynamically enhanced carbon-fiber bodies that loosely resemble the production cars on which they are also based, these supercharged, fuel-injected, nitromethane-burning machines travel the quarter-mile in 4. جماع رجال مع نساء Lick Kiss - Just before kissing, gently run your tongue along you partners lip whether it be the top or bottom one depending on the position of your lips. Move your tongue around it, gently sucking and licking. رجال وبنت A race car engine might also idle at 1,000 RPM and can accelerate to 15,000 RPM -- a multiplier of 15. جماع رجال مع نساء A large diesel engine usually cannot get above 2,000 RPM, but has huge torque because of the long stroke.
The National Cosplay Championship will also be officially launched in Melbourne on 27 March at the Supanova pop culture expo. جماعي As with boot-cut hems, the trend began in Europe and spread rapidly around the world. At one point, رجال يرتد فوطه mentions that he�s not an idealist anymore; now he just figures he should not also try to take care of the people he loves and stop trying to change the world. By this measure, one horse can raise 33 pounds 1,000 vertical feet in a minute, or 330 pounds 100 feet in a minute, or 3,300 pounds 10 feet in a minute, and so on.
جماعي The car, which is sponsored by DragStar Racing, will be part of Cunningham Ford Pro Stock Racing program.


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Ktool The Girth
UG Member
Join date: Aug 200720 IQ
how should i go about learning to sweep pick? i have absolutely 0 skill in it and am looking for some beginner exercises to learn how to sweep pick.
Just some dude.
Join date: Jul 2007154 IQ
Check the Advanced Techniques forum under Musician Talk, there's a few threads on sweeping there, and some sweep picking lessons on Youtube that give good examples for beginner sweep shapes.


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Home » Flash Games » RPG Games » Mardek
Mardek is a great RPG with an engaging storyline. The game allows you to save your progress and then come back later to continue, so it's sure to keep you returning for more!
Viewed 11,734 times (2 times today).
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Photog Sues Random House Publishing Firm Over Use of Pat Tillman Photo
The latest book in the "we-love-Pat-Tillman" saga, Where Men Win Glory, by John Krakauer, features a photo of the former Arizona Cardinal staring heroically into the distance while standing on top of a mountain in Afghanistan.
It's enough to make any football fan weep.. One problem -- the guy who took the photo claims the book's publisher, Random House, had no right to use it.
Ed Darack is suing the publisher in a Manhattan federal court for copyright infringement because he claims Random House unilaterally changed the terms of a contract he signed.
Darack, according to Courthouse News, claims that a contract was signed between his subagent, Getty Images, and Random House for the use of the photo in a book that was to be published on November 1, 2013.
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According to Darack, after releasing the Krakauer book, Random House changed the date of the sale to October 2009 so it could use the image in that.
Random House did not return our phone call.
Darack is seeking unknown monetary damages from Random House and Doubleday publishing firms.
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House of Ho
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Palm Springs, Calif., has been a redoubt for snowbirds and show business royalty at least since the 1930s.
Multigenerational Housing Will Be A Conversation Topic At Thanksgiving
"What do you think of the pumpkin pie?" your mom asks. "Hey, what do you think of the election? Do you think we should sell our homes and buy a big, new home together?"
Many topics will be discussed at Thanksgiving, including multigenerational housing. NAR's Economists' Outlook blog says that families are very influential when it comes to pushing multigenerational housing on potential homebuyers.
The living arrangements are becoming more common. This year, 11 percent of all buyers purchased a multigenerational home. The houses were typically 2,100 square feet with four bedrooms and two bathrooms, and purchased for $251,000.
The main reasons for purchasing a multi-generational home were for the health and caretaking of aging parents (19 percent), cost savings (18 percent), children or relatives over 18 moving back into the house (14 percent), to spend more time with aging parents (eight percent), and wanting a larger home that multiple incomes could afford (seven percent).


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It's time to Cherish the Season with the most Enchanting Collection of the Summer. Gul Ahmed Festive Collection '15 would be launching soon.
Complete range of Gul Ahmed Eid collection 2015 / 2016 with prices falling in different ranges is in stores from 30th May 2015. Gul Ahmed Eid Catalog 2015 suits are available in variety of colors and fabric options. It's a big collection and introduces new dresses in Silk, Shefun, Chiffon and Lawn fabrics available in printed as well as in embroidered styles. We are listing complete collection here with prices categorized according to fabric. Check it out and decide which one you are going to buy as part of your Eid Collection for 2015 by Gul Ahmed season.


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Frank Lehrman: Murder two? Why even have it on the menu? This isn't murder, it's manslaughter.
Ben Stone: So you're admitting she killed them?
Frank Lehrman: No. But if she killed them, it was extreme emotional disturbance, and that's manslaughter.
Ben Stone: I get it, she wasn't there. And if she was there, she didn't kill them, and if she did kill them, she didn't mean to, and if she did mean to, it's because she was upset.
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text: Bulldog does NOT like being called Buttkiss Uncategorized Jan 27, 2014 by SHEmazing! Team Share On Facebook Share On Twitter Share By Email Aww, little Ellie doesn't appreciate the new name her owners are giving her Trending BREAKING: Gardaí at the scene of a shooting in Dublin housing estate Plantstagram! 5 ways to take better care of your precious indoor plants 10 pairs of trophy boots to see you through this rainy AF weather David Mueller considering appeal following Taylor Swift's victory Noel Gallagher to headline Manchester Arena reopening gig Violent alt-left: Trump on white nationalist rally, Charlottesville


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I purchased this to go into the bathroom I redid next to my new home gym. Purchased the yoga shower curtains as well. Looks great.Read More
Perfect Christmas gift for someone into yoga. She loved it.Read More
It's lovely, and goes with previous items selected.Read More
Yoga Stretch Elegant Meditation and Relaxation Unique Hand Carved Brown Suar Wood Decorator Art Work Sculpture (Indonesia)
Sale $35.54


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Home >> Colorful Modified Silencer Pipe Tail Exhaust Muffler Tip for Car
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Logo Design
Budget R$30-90 BRL
Eu preciso de um freelancer para me ajudar com Logo Design , meu orçamento é em torno de R$ 30 - 90 BRL e preciso esse projeto feito dentro de 3 days
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"I don't know why Ginny gives us Invergarry Crab Cakes every time we go to dinner; it's not as if they were particularly nice."
Virginia Barton
". . .A commonplace book is what a provident poet cannot subsist without, for this proverbial reason, that 'great wits have short memories:' and whereas, on the other hand, poets, being liars by profession, ought to have good memories; to reconcile these, a book of this sort, is in the nature of a supplemental memory, or a record of what occurs remarkable in every day's reading or conversation. There you enter not only your own original thoughts, (which, a hundred to one, are few and insignificant) but such of other men as you think fit to make your own, by entering them there. . ."
The "few and insignificant thoughts" are exactly what will be found here in Commonplaces.
15 August 2017: Greatly blessed
"Glorious Queen of Heaven…"
11 August 2017: One for Sorrow, Two for Joy
Handsome is as handsome does, and magpies do not.
4 August 2017: Pot & Kettle, Splinter & Plank
The Nurse handed me a pamphlet called something like "The Benefits to Seniors of Losing Weight, and How to Go About it." It was brightly coloured with a logo of a fat person with a dismal Smiley face, and a thin person with a cheerful one.
31 July 2017: Return to Ypres and Passchendaele
If you happened to watch the live relay of the centenary Commemoration from the Menin Gate on the BBC last night, you could not have failed to be moved by the 54,000 names inscribed there.
28 July 2017: A Hundred Years Ago
It is difficult to put individual faces to these brave young men. They seem to have been swallowed up in the great maw that was World War I.
22 July 2017: A Little Extra
Many apologies, humbles (remember those?) and a breast-beating mea culpa. Do admit it is not like me to be so rude. It's the excitement of the "Snail" of course, emerging from hiding, and creating small havoc.
19 July 2017: Beloved Snail
The "Snail" has broken cover! Come out from under a flower pot and is now rampant! Exposed to the rigours of the market.
14 July 2017: Bastille Day
It is said they only found one mad old man in the Bastille when they stormed it on this day in 1789. This info may well be fabricated and based on Dr Manette in "A Tale of Two Cities."
7 July 2017: SW19
The title of this Commonplace has been referred to as "the most famous postcode in the world." Hands up those who know where it is and to what it refers?