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A gene signature for post-infectious chronic fatigue syndrome
At present, there are no clinically reliable disease markers for chronic fatigue syndrome. DNA chip microarray technology provides a method for examining the differential expression of mRNA from a large number of genes. Our hypothesis was that a gene expression signature, generated by microarray assays, could help identify genes which are dysregulated in patients with post-infectious CFS and so help identify biomarkers for the condition.
Human genome-wide Affymetrix GeneChip arrays (39,000 transcripts derived from 33,000 gene sequences) were used to compare the levels of gene expression in the peripheral blood mononuclear cells of male patients with post-infectious chronic fatigue (n = 8) and male healthy control subjects (n = 7).
Patients and healthy subjects differed significantly in the level of expression of 366 genes. Analysis of the differentially expressed genes indicated functional implications in immune modulation, oxidative stress and apoptosis. Prototype biomarkers were identified on the basis of differential levels of gene expression and possible biological significance
Differential expression of key genes identified in this study offer an insight into the possible mechanism of chronic fatigue following infection. The representative biomarkers identified in this research appear promising as potential biomarkers for diagnosis and treatment.
Persistent fatigue after infection is recognised and forms part of a clinically-defined syndrome (chronic fatigue syndrome or CFS). CFS is a highly heterogeneous illness which is characterised by the presence of new-onset, persistent or relapsing fatigue of sufficient severity that interferes with normal activity. Patients also report impaired short-term memory and concentration, muscle pain and post-exertional malaise
In recent years, numerous microarray studies have been undertaken in order to distinguish patients with chronic fatigue from healthy controls. This subject has also been covered extensively in a special 2006 issue of the journal Pharmacogenomics. In this issue, several papers utilised numerous multivariate projection methods, bioinformatics, algorithms and computational analyses of microarray data, in order to provide better discrimination of subjects with unexplained chronic fatigue and CFS, from healthy controls
Although chronic fatigue is well recognised after certain infections (for example, Lyme disease and Epstein-Barr virus), CFS is not commonly considered to be due to persistent infection. A preceding history of non-infection is frequently reported and recent studies indicate other factors may be responsible for the symptoms of this condition
We hypothesised that patients with persistent fatigue developing after community-acquired infections are biologically different from healthy subjects and this would be reflected in a differential gene signature. Recent advances in genome sequencing and automated chip manufacture have made DNA chip or microarray technology readily available
In our study, we aimed to obtain a complete "gene signature" for non-psychiatric patients with post-infectious persistent chronic fatigue. We excluded female subjects in order to avoid confounding factors from the monthly reproductive cycle. By using an Affymetrix GeneChip Human Genome U133 double-chip set that contains nearly 45,000 probe sets, representing 39,000 transcripts derived from more than 33,000 human gene sequences, most of the known human genome was encompassed in this work.
Study subjects
All patients underwent full medical and neurological evaluation clinically and had appropriate investigations to exclude alternative explanations for their symptoms. All patients with CFS fulfilled the international research criteria for diagnosis
Male patients with post-infectious CFS and normal healthy controls underwent venous blood sample collection (prior to 11 am) in 2 × 5 ml EDTA tubes. PBMC were isolated immediately and stored within 2 hours of sampling. EDTA-treated whole blood was diluted 1:1 with phosphate buffered saline (PBS). Two volumes of blood were overlaid onto one volume Histopaque-1077 (Sigma) and centrifuged at 20°C, 500 g for 30 min. The PBMC interfaces were washed twice with PBS and the pellets were re-suspended in PBS. Aliquots were counted and dry pellets (2 × 105 cells) were stored under liquid nitrogen.
RNA preparation
Total RNA was isolated from PBMC pellets following the detailed manufacturer's protocols in the Promega RNAgents Total Isolation System.
Microarray Assay
RNA quality was confirmed using an Agilent RNA BioAnalyzer 2100. The target samples were prepared following GeneChip One-Cycle Target Labeling protocol (Affymetrix). All 15 samples were then hybridised to Affymetrix GeneChip HG-U133A and HG-U133B arrays. The arrays were washed and stained using Affymetrix protocols on the Fluidics Station 400 and scanned on the Gene Array Scanner 2500.
Analysis: Analysis
GCOS1.1.1 software (Affymetrix) was used to generate raw data from scanned images. Data analysis was performed using FunAlyse, an in-house built automated pipeline in Sir Henry Wellcome Functional Genomics Facility (SHWFGF), University of Glasgow.
This analysis consists of the Robust Multichip Average (RMA) normalisation
The above RP-generated expression profile was then analysed with the Ingenuity Pathway Analysis (IPA) software (Ingenuity® Systems,
The data discussed in this publication have been deposited in NCBI's Gene Expression Omnibus
Validation of defensin-α1
An additional cohort of 10 patients with CFS and 10 age- and sex-matched controls were recruited for Reverse Transcription-Polymerase Chain Reaction (RT-PCR) and western blot assays, in order to verify the microarray data for one of the putative biomarkers, defensin-α1.
cDNA synthesis and PCR were performed as described previously
sense 5'-CAAGAGCTGATGAGGTTGCT-3'
antisense 5'-GAAGGTACAGGAGTAATAGC-3'.
Western Blot
PBMC pellets were re-suspended in sample-reducing buffer (1 ml glycerol, 0.5 ml β-mercaptoethanol, 3 ml 10% SDS, 1.25 ml 1 M Tris-HCl, pH 6.7) and boiled for 5 min. The cell lysates were loaded onto 10% PAGE gels, each track equivalent to 2 × 105 PBMC. PAGE gels were assessed for equal protein loading by coomassie blue staining. The gels were then electrophoretically transferred onto PVDF membranes (BioRad), for 2 hours. Blots were blocked with 10% normal goat serum for 30 min, and then incubated for 2 hours at room temperature with a monoclonal antibody to human neutrophil defensin α1–3 (1:100, clone D21, HyCult Biotechnology, Netherlands), diluted in TBS/0.05% Tween-20. Proteins were detected with a 1:1000 dilution of alkaline phosphatase-conjugated goat anti-mouse IgG (Jackson Immunoresearch Laboratories, PA, USA) and protein bands were detected using SIGMA FAST BCIP/NBT.
Identification of differentially expressed genes
A number of genes were significantly over- or under-expressed in CFS patients, as compared to healthy controls, in genome-wide microarray analysis. The Rank Products analysis revealed that 413 Affymetrix probe-sets were significantly up-regulated and 189 significantly down-regulated (602 in total) in the CFS samples. Of the significantly up-regulated probe-sets, 141 showed the expression changed at least 2-fold and 20 at least 3-fold. The corresponding numbers for the down regulated probe-sets are 57 and 2, respectively.
IPA results
Annotating the above list of 602 differentially expressed probe-sets with EntrezGene IDs and subsequent submission to the IPA server resulted in successful mapping of the above probe-sets to 366 non-redundant "focus" genes with records in the IPA database. Of these, 286 genes were significantly up-regulated and 80 significantly down-regulated in the CFS samples. Of the significantly up-regulated genes, 105 genes showed that expression changed at least 2-fold and 16 genes at least 3-fold. The corresponding numbers for the down-regulated genes are 25 and 3, respectively. The ten most highly up-regulated genes and the three most highly down-regulated genes are presented in Table
Table 1
Top 10 up-regulated genes (+) and top 3 down-regulated genes (-) in post-infectious CFS patients
NCBI Accession Number
Lactotransferrin (LTF)
Defensin α1 (DEFA1)
Charcot-Leyden Crystal protein (CLC)
Haemaglobin, gamma A (HBG1)
Integrin α2B (ITGA2B)
Haemaglobin, gamma G (HBG2)
Defensin α4 (DEFA4), corticostatin
Integrin β3 (ITGB3), CD61
Chemokine (C-X-C) receptor 4 (CXCR4)
To investigate the biological context of genes differentially expressed in CFS patients, the IPA software was used, as described in Methods. Figure
Figure 1
High-level functional categories involved in this IPA analysis
High-level functional categories involved in this IPA analysis. Y-axis displays -(log) significance. A) Top 10 biofunctions for CFS patients and B) total biofunctions for CFS patients. Taller bars are more significant than shorter bars. Functions are listed from most significant to least and the horizontal line denotes the cut-off for significance (p < 0.05).
Figure 2
Differentially expressed gene networks
Differentially expressed gene networks. Networks showing differentially up-regulated genes (red) and down-regulated genes (green) in post-infectious CFS patients, whereby A) includes lactotransferrin (LTF, up-regulated 7.2-fold), B) includes CXCR4 (up-regulated 3.6-fold) and C) includes the integrins α2B and β3 (up-regulated 4.1 and 3.8-fold, respectively) and defensin-α1 (up-regulated 6-fold).
Altered bio-systems in CFS
The gene signature of CFS highlighted changes in gene expression in three main areas: oxidative stress, apoptosis and viral-like immune dysfunction. These genes are summarised in Table
Table 2
Three altered bio-systems in CFS
Oxidative Stress Genes
Prostaglandin Synthase: COX-1 and 2, haemoglobin gamma A and gamma G
Apoptosis Genes:
Annexin -A3, -A5, Serine/threonine kinase 17b, Histones 1&2, Protein S (alpha), Serum deprivation response (Phosphatidylserine binding protein)
Caspase 1, TGFβ1
Death effector filament forming CED4-like apoptosis protein, Complement 3a receptor 1, Early growth response 1, TNF-A1P3, -RSF17, -SF4
Immune Dysfunction Genes (including markers of viral immuno-modulation/evasion)
Antigen processing via MHC class II (MHC II DP α1 and DR α)
IL-12, IL-13 & IL-6 biosynthesis
Natural Killer cell receptors (KIR)
TCR complex (T-cell receptors α, β, δ, γ)
NO production (up-regulation of arginase I & II)
Flavohaemoprotein B5
Leukocyte-derived arginine aminopeptidase (L-rap)
Oxidative stress
There is a large body of evidence from researchers in CFS indicating that oxidative stress contributes to disease progression and resultant symptoms
There is active apoptosis in the cells of patients with CFS and consistent with this is the finding that many apoptosis-associated genes are up-regulated, including Caspase 1 (Table
Immune evasion is a well-documented mechanism by which viruses, bacteria, parasites and cancer cells avoid destruction by the host. Immune modulations can be varied and complex. They include targeted disruption of T-cell function, suppression of T-cell cytotoxic death receptors, induction of apoptosis proteins, inhibition of innate immune systems such as dendritic cell and natural killer (NK) receptors. From this study, several genes associated with the immune system are shown to be up-regulated in patients with CFS, thus indicating possible functional alterations (Table
In addition to the MHC, within the top up-regulated genes there are several genes encoding immune proteins which belong to the innate immune system. Patients with CFS have been suspected to have subtle immune dysfunction. Altered NK cell function in CFS patients has been reported previously by Morrison
The immune modulation in post-Lyme disease fatigue is remarkably similar to the gene signature presented here for patients with CFS
Up-regulated immune-related genes in patients include lactotransferrin, defensin-α1 and integrins. Lactotransferrin is an iron-binding protein responsible for immunological reactions, while defensins are a family of microbicidal and cytotoxic peptides released in response to viral and bacterial infections. Defensins are also involved in the anti-microbial defence of epithelial surfaces (i.e. respiratory and urinogenital tracts). Patients with CFS are known to have increased susceptibility for infections and candidiasis is frequently reported
Integrins are extracellular matrix proteins involved in cell adhesion and also activate cytosolic signal cascades for cell growth and regulation. Arginase is a key enzyme considered to be active in immune modulation and is also involved in NK cell function. Other notable up-regulated genes include haemoglobins, especially foetal haemoglobin, and this may suggest a response to increased oxidative stress. Another family of up-regulated genes relate to cellular apoptosis and serine-threonine kinase is a member of brain kinase family of protein implicated in neural apoptosis and formation of corpora amylacea. Of the down-regulated genes, ribosomal protein gene and zinc finger protein genes are involved in cell cycle and cellular growth.
Validation of gene array data using RT-PCR and western blotting
Two members of the defensin gene family were found to be amongst the most highly over-expressed genes in the microarray; defensin-α1 and -α4. Defensins are a family of cytotoxic peptides found in the microbicidal granules of neutrophils and macrophages, and are released in response to viral and bacterial infections. These proteins are thus likely to play a role in phagocyte-mediated host defence. As a result of the high defensin levels identified in the microarray data, defensin-α1 was chosen for further analysis. We aimed to confirm this data at the RNA and protein level, using another cohort of blood samples from 10 CFS patients and 10 normal healthy controls. Oligonucleotides and antibodies specific to defensin-α1 were used to detect and compare changes at the RNA and protein level using RT-PCR and western blotting, respectively. Figure
Figure 3
RT-PCR assay and western blot analysis
RT-PCR assay and western blot analysis. Detection of over-expression of defensin-α1 in CFS patients compared to normal healthy controls. A) 25 μl of each PCR product was electrophoresed through a 2.5% agarose gel, ethidium bromide stained and UV visualised. Lanes: L: DNA size ladder; 1–3: Healthy controls; 4–6: Patients with CFS. B) Western blot analysis. Each lane contained 2 × 105 PBMC and equivalent protein loading of all samples was confirmed by coomassie blue staining. Left-hand side of blot: 10 CFS patients; right-hand side of blot: 10 healthy controls.
A comprehensive gene signature of non-psychiatric patients with CFS has been generated by a whole-genome microarray assay. The microarray data presented here illustrates differences in gene expression across the human genome between post-infectious, non-psychiatric male patients with CFS and healthy controls. Analysis of the gene signature of CFS suggests that three significant pathways are altered in patients: oxidative stress, apoptosis and viral-like immune modulation. Previously, Gu
The overall picture emerging from these results point to a significant, albeit phenotypically subtle, perturbation of function in relation to microbial defence, viral immuno-surveillance and cell growth amongst patients with post-infectious chronic fatigue. A possible criticism of the work is that female patients were excluded. As already explained, the primary reason for exclusion was to avoid any confounding endocrine influence on gene signature. Previous research has found few gender-related differences in terms of symptom severity. There was no gender effect in a prospective cohort study of patients with post-infectious fatigue attending primary care
Recent studies have attempted to determine the molecular basis of CFS
Table 3
Commonly overexpressed CFS genes between current study and previous microarray studies
CEACAM family
CEACAM family
Defensin family
Defensin family
The data presented here clearly illustrate important differences in gene expression between patients with post-infectious CFS and healthy controls. While these differences in gene signatures may offer a rational explanation for the symptoms, and confirm that CFS is a true and biological illness, gene microarray results do not imply that CFS is primarily a genetic disorder. In addition, the research data do not prove if differentially expressed genes are the predisposing cause or downstream effect of CFS. We believe, however, that the data presented here is an important first step forward towards the goal of identifying putative biomarkers to support the clinical diagnosis of CFS. Furthermore, the biological pathways identified by the over-expressed genes offer a rational understanding and possible explanation of the complex and often multi-systemic nature of CFS, which is common and remains a potentially disabling illness in search of an effective cure.
List of Abbreviations
CFS: Chronic Fatigue Syndrome; DAF: Decay Acceleration Factor; FC: Fold Change; FDR: False Discovery Rate; GMN: Global Molecular Network; IPA: Ingenuity Pathway Analysis; MHC: Major Histocompatibility complex; NFκB: Nuclear Factor kappa B; PBMC: Peripheral Blood Mononuclear Cells; RT-PCR: Reverse Transcription-Polymerase Chain Reaction; RMA: Robust Multichip Analysis; TLR: Toll-Like Receptor.
Competing interests
The Court of the University of Glasgow has filed a patent entitled "Materials and Methods for Diagnosis and Treatment of Chronic Fatigue Syndrome" Patent File Number GB0502042.5.
Authors' contributions
AC, CC and JG participated in the design and coordination of the study, carried out the molecular genetic studies, participated in the sequence alignment and helped to draft the manuscript. CC carried out the immunoassays. PH carried out the IPA analysis and performed the statistical analysis. SH carried out the analysis and interpretation of IPA analysis and drafted the manuscript. PB participated in the design of the study and drafted the manuscript. All authors read and approved the final manuscript.
This manuscript is dedicated to the memory of Professor WMH Behan (1939–2005).
The authors wish to thank Drs G. Riboldi-Tunnicliffe and S. Keir for expert assistance and would like to acknowledge the financial support of The Cunningham Trust, The Barclay Foundation, Scottish Enterprise, the ME Association and ME Research UK during the course of this work.
The chronic fatigue syndrome: a comprehensive approach to its definition and study
A community-based study of chronic fatigue syndrome
The prevalence and morbidity of chronic fatigue and chronic fatigue syndrome: a prospective primary case study
Gene expression profile of empirically delineated classes of unexplained chronic fatigue
Polymorphisms in genes regulating the HPA axis associated with empirically delineated classes of unexplained chronic fatigue
Identifying illness parameters in fatiguing syndromes using classical projection methods
Gene expression profile exploration of a large dataset on chronic fatigue syndrome
Not in the mind of neurasthenic lazybones but in the cell nucleus: patients with chronic fatigue syndrome have increased production of nuclear factor kappa beta
Not in the mind but in the cell: increased production of cyclooxygenase-2 and inducible NO synthase in chronic fatigue syndrome
Preliminary evidence of mitochondrial dysfunction associated with post-infective fatigue after acute infection with Epstein Barr virus
Gene expression correlates of postinfective fatigue syndrome after infectious mononucleosis
DNA Chip Technology
Utility of the blood for gene expression profiling and biomarker discovery in chronic fatigue syndrome
Gene expression in peripheral blood mononuclear cells from patients with chronic fatigue syndrome
Exercise responsive genes measured in peripheral blood of women with Chronic Fatigue Syndrome and matched control subjects
Summaries of Affymetrix GeneChip probe level data
Rank products: a simple, yet powerful, new method to detect differentially regulated genes in replicated microarray experiments
Rank-based methods as a non-parametric alternative of the t-statistic for the analysis of biological microarray data
Comparison and evaluation of methods for generating differentially expressed gene lists from microarray data
A benchmark for Affymetrix GeneChip expression measures
Entrez Gene: gene-centered information at NCBI
Gene Expression Omnibus: NCBI gene expression and hybridization array data repository
Long RT-PCR amplification of full-length enterovirus genome
Genomic and template RNA transcription in a model of persistent enteroviral infection
TNF-alpha and chronic fatigue syndrome
Blood parameters indicative of oxidative stress are associated with symptom expression in chronic fatigue syndrome
Antioxidant status and lipoprotein peroxidation in chronic fatigue syndrome
Relationship between musculoskeletal symptoms and blood markers of oxidative stress in patients with chronic fatigue syndrome
Oxidative stress levels are raised in chronic fatigue syndrome and are associated with clinical symptoms
Increased neutrophil apoptosis in chronic fatigue syndrome
Differential-display PCR of peripheral blood for biomarker discovery in chronic fatigue syndrome
Association of chronic fatigue syndrome with human leucocyte antigen class II alleles
Changes in natural killer cell phenotype in patients with post-viral fatigue syndrome
Decay-accelerating factor expression on either effector or target cells inhibits cytotoxicity by human natural killer cells
Interaction of decay-accelerating factor with coxsackievirus B3
A decay-accelerating factor-binding strain of coxsackievirus B3 requires the coxsackievirus-adenovirus receptor protein to mediate lytic infection of rhabdomyosarcoma cells
dra-related × adhesins of gestational pyelonephritis-associated Escherichia coli recognize SCR-3 and SCR-4 domains of recombinant decay-accelerating factor
Early Lyme disease: Humoral immune status and treatment
Antigen-specific gene expression profiles of peripheral blood mononuclear cells do not reflect those of T-lymphocyte subsets
Increased number of Candida albicans in the faecal microflora of chronic fatigue syndrome patients during the acute phase of illness
A 588-gene microarray analysis of the peripheral blood mononuclear cells of spondyloarthropathy patients
Gene expression signature and the prediction of ulcerative colitis-associated colorectal cancer by DNA microarray
Blockade of CXCL12/CXCR4 axis ameliorates murine experimental colitis
Postinfectious fatigue: prospective cohort study in primary care
Gender differences in patients with chronic fatigue syndrome
Gene expression subtypes in patients with chronic fatigue syndrome/myalgic encephalomyelitis
Seven genomic subtypes of chronic fatigue syndrome/myalgic encephalomyelitis: a detailed analysis of gene networks and clinical phenotypes
Identification of marker genes for differential diagnosis of chronic fatigue syndrome
Gene expression profiling in the chronic fatigue syndrome
Pre-publication history
The pre-publication history for this paper can be accessed here:


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There are 186 rooms and 75 suites in this hotel. All the accommodations are spacious and decor luxuriously. Most of the rooms have windows so that guests can enjoy the view of the mesmerizing city. If you are planning any vacation and looking for an ambiance that can be soothing and relaxing for your body mind and soul. Trump International […]Read more ›


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BAC currently has partnerships and affiliations with over 20 foreign universities and professional organisations, offering its students access to over 100 world-class Law and Business degrees and professional qualifications that can be completed either locally or abroad.
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Get Your License
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Home / Continuing Education / Florida / 15-Hr. FL CE Package - Commercial (with Ethics course)
15-Hr. FL CE Package - Commercial (with Ethics course)
15 Total hours
12 Elective hours
3 Law hours
Save time and money with this package built exclusively for agents with an interest in commercial real estate. This full package includes 3 law hours and 12 specialty hours.
Courses included in this package:
- Florida Core Law (3 law hours)
- Anatomy of Commercial Building (3 specialty hours)
- Commercial Ethics (3 specialty hours)*
- Commercial Landlord Representation (3 specialty hours)
- The Fundamentals of Commercial Real Estate (3 specialty hours)
*This course meets the REALTORS® Code of Ethics Training (formerly known as NAR QUADRENNIAL) Requirement. You will need to confirm with your local REALTOR association if they will accept it.


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Johns Hopkins astrophysicists to help solve universe`s `dark` mysteries
Brice Menard and Charles L. Bennett of Johns Hopkins will join the mission, led by The European Space Agency (ESA), which is scheduled to launch in 2020.
Washington: Two Johns Hopkins astrophysicists have been appointed to the Euclid Consortium, the international team of scientists overseeing an ambitious space telescope project designed to probe the mysteries of dark energy and dark matter.
Brice Menard and Charles L. Bennett of Johns Hopkins will join the mission, led by The European Space Agency (ESA), which is scheduled to launch in 2020.
NASA, a partner in the mission, recently announced their selection to the research team for Euclid.
A recent announcement about the ESA-NASA partnership stated that Euclid`s telescope and scientific instruments "will map the shape, brightness and 3D distribution of two billion galaxies covering more than a third of the whole sky and looking back over three-quarters of the history of the universe."
"Euclid`s observations will produce a flood of data and will enable an impressive range of investigations," said Menard, a Johns Hopkins assistant professor of physics and astronomy.
"This space telescope will be capable of mapping out a large fraction of the sky. It will provide us with detailed observations of more than a billion galaxies. It`s going to provide a gigantic new dataset. What we need to do now is to come up with strategies for analyzing that much material," he added.
The agencies hope this mapping process will yield important new information about the behavior of dark matter and dark energy. In gathering such data, Bennett said, "We`re trying to learn about the evolution of the universe and fundamental physics. We want to know more about what the universe is made of and how it is changing."
Dark matter and dark energy are now known to be major ingredients in the makeup of the universe.
NASA`s Wilkinson Microwave Anisotropy Probe (WMAP) space mission, led by Bennett, recently determined that the universe is composed of 4.63 (plus or minus 0.24) percent atoms, 23.3 (plus or minus 2.3) percent dark matter and 72.1 (plus or minus 2.5) percent dark energy. Remarkably, several other measurements are consistent, and when data are combined improve the precision.
However, the identity of the dark matter particles remains a mystery and scientists do not yet understand how dark energy changes with time or how it affects the evolution of the universe. The nature of dark energy has become one of the most fundamental questions in physics today, and scientists hope the upcoming space mission will help provide answers.
"Indeed," said Bennett, "what we call dark energy could be an indication of a failure of Einstein`s theory of gravity, one of the bedrock theories of physics."
"Euclid`s observations will push the exploration of the universe to new limits. Together with European colleagues, Brice and I will begin a multi-year process that could revolutionize our view of the cosmos," he added.


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Hello Lady & Gentlman,
I`m looking for the method about one of convert work.
When convert, we can rendition check and after rendition checking. convert result file is upload the server or fixed drive.
Our customer want to only save in the fixed drive convert result file.
This mean is Client user not handling the rendition check box. and client user not shuld be able to save the convert result file in the local PC.
Here is
I`m find out the method How to do that renditon check and lock up.
And I need to advice and source code for this.
Please help me .
The "Rendition" check box is enabled if connected to a DMS and DMS allows rendition of such format.
The rendition formats are requested from DMS using this property : Property.CSI_Renditions.


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Still no (good) video calling on Ubuntu
A new version of Skype is released for Linux (Ubuntu Feisty Fawn). I was really hoping for video calling to be enabled since this is the one feature I'm missing in general on Ubuntu. But no. The new version is cleaned up and more stable -but no video. I tried Ekiga, a SIP calling client, that seems to work with a lot of hassle -but it's not easy enough.
So, unfortunately, no video calling is still a big drawback on the Linux box.
Read more about Skype 1.4 for Linux


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This hotel is fine for a short stay. Room was clean and comfortable and room enough to move around. There was no cover on the air vent, and we were a little uncomfortable about particles blowing out of the unit. The halls and room had a peculiar smell. It was nice to have a micro wave and refrigerator; however the refrigerator was barely cool. There were no towels so we called down to the lobby. They told us that they were out of clean towels, but would bring some up in about 15 min. We were meeting friends for dinner and wanted to take a shower first. Still no towels an hour later – called back down and they finally brought some up, but not in time for us to shower before dinner. Staff was pleasant enough, but certainly wouldn't call it a warm welcome. One thing that really surprised us was their local guide. For an area that has so many dining establishments, they listed only 7, one of which is in San Francisco. There were only 3 or 4 points of interests. Thankfully we are familiar with this area and really didn't need guidance, but if we were not, the guide would have been totally worthless. Because we booked through Orbitz, we got a good deal, so we were ok with this hotel at that price, however, if we would have paid the hotel asking price, we would not have been happy.
- Official Description (provided by the hotel):
- Come discover the preferred destination of travelers visiting the Santa Ynez Valley, the Holiday Inn Express Solvang. We are centrally located in the Danish Town of Solvang, walking distance to all of its major attractions. It is best known for its shopping, restaurants, chocolate factories and wine tasting rooms! Our hotel is centrally located within Santa Barbara County's Wine Valley. The Holiday Inn Express Solvang is within minutes to Vandenberg Air Force Base, renowned Wineries such as Firestone, Gainey, Buttonwood and Rusack. If you are a golf enthusiast then make the Holiday Inn Express Solvang your golfing headquarters. With our Monthly Golf Packages, you can golf at courses such as The Alisal River Course and La Purisima Golf Course.Our hotel is conveniently located just 30 minutes from the city of Santa Barbara, 20 minutes from Vandenberg Air Force Base and 30 minutes away from Santa Maria. ... more less
- Reservation Options:
- TripAdvisor is proud to partner with Booking.com, Hotels.com, Expedia, IHG, Orbitz, Travelocity, TripOnline SA, Hotwire, Cheap Tickets, Cancelon, getaroom.com and HotelQuickly so you can book your Holiday Inn Express Solvang reservations with confidence. We help millions of travelers each month to find the perfect hotel for both vacation and business trips, always with the best discounts and special offers.
- Also Known As:
- Holiday Inn Express Solvang Hotel Solvang


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Our 2013 The Path Merlot is garnet in color with aromas of cranberry, cherry-cola and tobacco leaf. The flavors in this wine are robust, you can find things like tart cherry, plum, warm baking spices and dried cranberry. French and American oak aging adds flavors like vanilla and clove, which create for a multifaceted profile. Medium-plus bodied, this wine can pair with many dishes. Try with spaghetti with marinara sauce, grilled chicken with rosemary roasted red potatoes or salmon with mushroom orzo.
Type: Wine
Tags: 2014, California, Merlot, USA,
Want to be the first to know about new products, special discounts, and sneak peeks?
Store hours of operation: Sun: 12pm - 7pm,
Mon - Thurs: 10am - 9pm,
Fri - Sat: 9am - 10pm


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Generated Page Name: /children/ContentModules/TreatmentPrograms/Pediatric_Radiation_Oncology_1624.html
Active status: Active
Name of Treatment Program: Pediatric Radiation Oncology
Short description: Mass General and the Department of Radiation Oncology have played a critical role in the development and refinement of proton radiotherapy. We have one of the largest pediatric programs in the world and have treated well over 1,600 children. We are the only proton center in New England, and an international referral center for pediatric radiation oncology.
Image: /children/assets/images/interior_pages/mghfc_kid_135x145_44.jpg
Alt text: Photo of happy, healthy child
Call To Action 1: phone*Contact the Department of Radiation Oncology at:|617-724-1836
Call To Action 2: button*Support Pediatric Radiation Oncology|/children/give/pediatric-radiation-oncology.aspx
Call To Action 3: button*Reach us through Patient Gateway|/children/services/patient-gateway.aspx
Repeat calls to action:: 1
Our approach:
MassGeneral Hospital for Children's Department of Radiation Oncology provides radiation therapy to treat a variety of tumors in children using the most current techniques available. The Mass General Department of Radiation Oncology was the first proton center in the United States to pioneer proton radiotherapy in the pediatric population and has been treating children with fractionated proton radiotherapy since 1974.
The goal of radiation therapy is to destroy or shrink tumor cells without damaging surrounding healthy tissue, often together with surgery and/or chemotherapy depending on the tumor that we are treating.
Radiation plans are custom designed for each patient in order to target the tumor with maximum sparing of healthy tissue. At Mass General we have access to many types of radiation including photons, electrons, and protons. Proton therapy is the most common form of radiation used to treat pediatric patients at Mass General.
An integral part of one of the world's most distinguished medical centers, Mass General's Francis H. Burr Proton Therapy Center represents the forefront of technological advances in radiation therapy coupled with expert, comprehensive, and compassionate family-centered care. We employ image guidance with all of our proton treatments and use both passively scattered 3D conformal proton radiotherapy as well as pencil beam scanning. Proton radiosurgery is also readily available. Proton radiation therapy is unique, because more than any other type of radiation, protons allow radiation to be directed to a very limited area, which reduces potential damage to nearby healthy tissues. This is particularly useful for certain tumor types in children where long-term effects on growth and development are very important. Children's bodies are more vulnerable to the effects of radiation, so any healthy tissue that can be spared becomes vital.
In addition to proton therapy, MassGeneral Hospital for Children also provides state-of-the-art stereotactic radiosurgery (SRS), stereotactic radiation therapy (SRT), and intensity modulated radiation therapy (IMRT). In all types of radiation, our radiation oncologists work with clinical physicists to bring the latest technological developments to our patients, from respiratory or cardiac gating, to cone-beam CT, and adaptive radiotherapeutic planning. Treatment plans are created using the most advanced computing and imaging techniques. Our radiation oncologists and physicists have access to a complete array of devices to carefully administer radiation to target tissues while minimizing radiation exposure to uninvolved tissue.
We understand that having a sick child is stressful for the child, parents, siblings and other family members. It is our goal to provide the highest quality care, while considering the unique needs of children with cancer and their families. For this reason, we have a multidisciplinary team approach. Our experienced and dynamic team includes specialists in pediatric oncology, pediatric radiation oncology, pediatric surgery, pediatric neurosurgery, pediatric neuroradiology, pediatric neurology, pediatric anesthesia, pediatric rehabilitation, pediatric nursing, social work, child life, and other support staff. Massachusetts General Hospital is home to the HOPESprogram which offers wellness services, free of charge, including music, art, massage, and acupuncture. These wonderful activities are open to patients and their families.
Pediatric Oncology: The doctors in the Division of Pediatric Hematology and Oncologyat MassGeneral Hospital for Children are our close partners in caring for our pediatric patients who come for proton radiotherapy, since many require chemotherapy during radiation treatment. Our pediatric colleagues provide personalized multidisciplinary, state-of-the-art care to children of all ages.
Spaulding Rehabilitation Hospitalhas a 12-bed private room pediatric unit which regularly treats our children who are in need of intensive inpatient rehabilitation. Commonly, children will be getting intensive rehabilitation while still getting their daily radiation treatments. The clinicians at Spaulding are experts in Posterior Fossa Syndrome as well as other neurological effects that can track with brain and spinal cord tumors. One parent at a time may stay overnight for as long as needed, and we have a welcoming visitation policy for family members, siblings and peers.
MassGeneral Hospital for Children Inpatient Facilities: Children admitted to the hospital for an overnight visit will stay in the Ellison Building at MassGeneral Hospital for Children. General medical and surgical-care patients stay on the 17th or 18th floor, complete with child- and adolescent-friendly rooms, playrooms and lounges. Each room also is equipped with a bathroom, shower and television. Laptop computers and game consoles also are available on inpatient floors. Each floor has a kitchen and laundry services for extended stays. Parents may stay overnight with their child in the room. See a video introduction to Ellison 17or Ellison 18, including who's who on staff and accommodations for parents and guardians staying overnight with children.
The Francis H. Burr Proton Therapy Center at Massachusetts General Hospital is the original proton therapy center in the United States. The proton radiation program builds on more than forty years of pioneering work and experience gained by physicians, physicists, researchers and clinical support staff at Harvard University's Cyclotron Laboratory. In the 1960's, the Harvard Cyclotron Laboratory was one of the world's first facilities to explore the use of protons in the treatment of patients with cancer. More than 9,000 patients were treated from 1961 to its closing in 2002. Fully operational in 2001, the new proton facility, the Francis H. Burr Proton Therapy Center, was made possible by funding from Massachusetts General Hospital and the National Cancer Institute. Additionally, due to the success of the proton radiotherapy program, we will be opening a fourth proton treatment room in 2017.
Treatment is available for pediatric brain tumors including:
As well as other pediatric tumors outside of the central nervous system including:
Please visit the National Cancer Institute for more information about cancer in children and adolescents.
At MassGeneral Hospital for Children, we know that the time of your child's diagnosis and treatment is a very stressful one, and we strive to provide an open, welcoming environment. We believe that no one knows a child as well as the parent does: parents, along with primary care providers, become our partners in a child's care and have an active voice in all treatment plans.
We believe it is important to have a comfortable place to for families to call home if they need to temporarily relocate for the duration of treatment. We understand what a stressful and overwhelming time this often is. Our team can help you find a place to stay, set up a tutor, and learn your way around Boston.
Other hotels and resources are available upon request by calling our American Cancer Society Patient Navigator, Abby Losordo, at 617-643-1742.
About this treatment:
Related conditions intro:
Support & Wellness:
Related news & events intro:
Related multimedia intro:
Phone number:
Multidisciplinary Care Center:
Spotlights: Donate - 1494
Contact: MGHfC Radiation Oncology - 1684
Tab1_label: Overview
Tab1_name: overview
Tab1_contentType: approach
tab2_label: Doctors
tab2_name: doctors
tab2_contentType: doctors
tab3_label: Conditions & Diseases
tab3_name: conditions
tab3_contentType: conditions
tab4_label: What We Treat
tab4_name: conditions
tab4_contentType: wysiwyg
tab4_content:
Information from the National Cancer Institute at the National Institutes of Health

Central Nervous System Tumors

Brain and Spinal Cord Tumor Overview

Medulloblastoma or Primitive Neuroectodermal Tumors (PNETs)are also known as embryonal tumors.

Ependymoma

Astrocytoma or Glial Tumors including Juvenile Pilocytic Astrocytoma

Craniopharyngioma

Central Nervous System (CNS) Germ Cell Tumors

Non-Central Nervous System Tumors

Rhabdomyosarcoma

Other Soft tissue sarcoma

Neuroblastoma

Bone cancer overview

Ewing's Sarcoma

Osteosarcoma

Retinoblastoma

tab5_label: Patient Education
tab5_name: patient-education
tab5_contentType: patient_education
tab6_label: Clinical Trials
tab6_name: clinical-trials
tab6_contentType: clinical_trial
tab7_label: News
tab7_name: news
tab7_contentType: news
tab8_label: Patient Stories
tab8_name: patient-stories
tab8_contentType: wysiwyg
tab8_content:

Charlie Beecher, shortly after he started proton beam treatment.

Charlie's Story: Instilling Confidence Through a High Standard of Care - 11/20/2015
 Charlie Beecher's family described the first two years of his life as joyously normal until Charlie developed belly pain. When they found out it was cancer, the Beechers brought Charlie to the Francis H. Burr Proton Therapy Center, which helped Charlie return to his normal, happy childhood.

Ryan's Story: Inspired by Compassionate Care to Achieve His Dreams - 9/21/2015
 When Ryan Schlosser received his master's degree this year, he thought of everyone who supported him along the way, especially his care team at the Francis H. Burr Proton Therapy Center at MGHfC, who played a larger role in his success than he ever imagined.

Alex's Story: Family-Centered Care Helps Kids Be Kids Throughout Challenging Treatments - 9/2/2015
 When Alex Sheehan was diagnosed with a brain tumor at age 10, staff at the Francis H. Burr Proton Therapy Center helped him simply be a kid during a challenging time.

Score! - 5/16/2014
 Exuberant MassGeneral Hospital for Children patient Devin Cheeks, 14, rang the bell marking his final treatment at the Francis H. Burr Proton Therapy Center on May 7.

Patients Find Mentors, Friends at Proton Center - 1/25/2011
 Pediatric patients mentor one another to undergo proton therapy without anesthesia.

tab9_label: Clinical Research
tab9_name: research
tab9_contentType: wysiwyg
tab9_content:
The Francis H. Burr Proton Therapy center is actively conducting MGH lead clinical trials for pediatric cancer patients treated with Proton Therapy here at Massachusetts General Hospital. While all of these trials are led by doctors at Massachusetts General Hospital, a number of these studies enroll patients from numerous hospitals across the country adding to the cooperative nature of our research. Learn more.

tab10_label: Video
tab10_name: video
tab10_contentType: multimedia
tab11_label: Contact
tab11_name: contact
tab11_contentType: contact


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"The matter is under the consideration of the Board. A final decision has not been reached. Efforts are on. We have not reached the stage of signing it," BCCI secretary S K Nair said in Bangalore.
He said the BCCI president Jagmohan Dalmiya is keen to see that the system is implemented as soon as possible.
"We have made it clear that discussions (with players) are over. Certain points, which would be in the form of documentation and to be signed by the two sides is being given shape," Nair said.
"I hope and expect that we will be able to sign it before the Asia Cup but there is no time frame (on signing)," he said. "The BCCI president has announced the intention of putting it in place before the Asia Cup but there is no time frame."
BCCI joint secretary Ratnakar Shetty said in Mumbai on Saturday that all the documentation needed for introducing the system have been completed and all's set for the signing before the team departs for the Asia Cup in the island nation.
As per the graded system of payment, the topmost players are to get Rs 60 lakh annually as fees, the middle rung players are to receive Rs 30 lakh and the rest would be bracketed in the Rs 15-lakh each category.


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Texas has beautiful historic bridges across this state, from metal truss bridges on county roads, to stone masonry bridges built by the Works Progress Administration and more. These structures tell the story of transportation across the state and are cherished by the communities they serve.
Are you a metal truss bridge owner? Read more here.
Metal Truss Bridges
These iconic bridges are increasingly old and rare in Texas, though hundreds are now in parks, hike-and-bike trails or bypassed along the side of the road.
Leading Bridge Innovation and Design after World War II
This interactive map shows more than 100 of these bridges are eligible for listing in the National Register of Historic Places for their historic and engineering significance.
Giving Old Bridges New Life
When historic bridges start aging, some can be rehabilitated for continued use, while others find new life in a park or as pedestrian bridges. Read successful stories below.
More Information
Interested in learning more? Want to research bridge history yourself? Visit these sites:


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About Forex Capital Markets
Forex Capital Markets (FXCM) aims to provide the highest level of execution and customer service available in the market today. To achieve this goal, FXCM focuses on providing products and services related exclusively to currency trading. FXCM set the standard for online currency trading with the release of the FX Trading Station in August 1999. Individual traders, money managers, and hedge funds quickly adopted the trading platform because of the efficiencies and cost savings offered over traditional dealing. Each year the volume traded on the FX Trading Station has doubled with more than $22 billion monthly recorded in 2002. This has enabled FXCM to build strong relationships with top tier global institutions. The trading volume that FXCM brings to these institutions insures that FXCM and its clients receive the most competitive pricing available. FXCM has over $500 million in credit lines from major financial institutions ensuring consistent liquidity and the ability to handle large volume transactions. Currently there are close to 8,000 clients that rely on FXCM's proven technology and established record of success. FXCM is a global firm with representation in over 20 countries. The headquarters is based in New York, which houses the firm's trading operations.


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Eat My Jelly game
Gish based physics! Guide this cute green jelly drop to his litle jelly food! Use the mouse to drag him and set the direction. Release the left mouse button in order to throw him in the desirable direction!
Eat My Jelly, play free Puzzle games, related games and updates online. Added on
Author: r4 117
Here are some more related games in Puzzle category. Also you can jump to other category using box above.
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Related games
- Eat My Jelly New Levels
- Eat My Jelly
- Eat My Jelly Level Pack
- Jelly Cat
- Adventure of Water Drop 2
- Jelly Cat Level Pack
- Water Drop Adventure 2
- Eat Jelly
- Blob and Blocks Level Pack
- The Lava Escape Arcade
- Jelly Tower
- Jelly Tower
- Blob and Blocks 2
- Water Drop Adventure
- Water Drop Adventure
- jelly drop
- Eat My Axe
- Follow Your Love
- Frooz Adventures
- My Island RPG
- Who Moved My Cheese
- Wheres My Blankie
- Mouse in my house
- Oh My Pinky Pinky
- DOLI- Wheres My Blankie 2
- Park My Tank
- MaoMaoQ
- CatchAroo


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Personalized Women's White Apron
$ 22.99
Save 23%
$ 29.99
Personalized Women's White Apron Description
Mom will love this fun, unique monogrammed apron. A personalized, monogrammed white apron will give them a special thank-you that they are sure to use and enjoy. Kitchens, decks, back yards - memories are made, among friends, who socialize over cooking and eating together. Tradition starts here.
Item Specifications:
- Personalize monogram initials (First, Last Middle Initial)
- Available in 20 different text colors
- Measures 28 3/8" x 19 1/2"
- Material Polyester/Cotton
- Two front pockets
Shipping Information
Most order will ship in 2-4 business days. Candles and favors will ship in 4-5 business days. Shipments originate from Medina, MN. Delivery times will vary depending on your proximity to our Medina, MN warehouse. When selecting our Standard Ground shipping option, most orders will be delivered within 7-10 business days from the day the order ships. Weekends and holidays are excluded.
We offer 5 shipping methods which can be chosen at checkout. For orders shipping to Canada, Alaska and Hawaii, please select the specific shipping service.
Within the contiguous United States
- Economy Ground Shipping - Delivery in 5 - 10 days - $5.99
- Fast - Delivery 4-5 business days - $35.00
Alaska and Hawaii Service - Delivery in 7-8 business days
- $30.00
Canada - Delivery in 7-10 business days
- Delivery in 7-10 business days - $30.00
Shipping to Canada is via UPS only. Delivery time is typically 7-10 business days. Customer is responsible for all duties and tariffs. We do not ship orders to any other international destinations.
*Orders received after 12:00pm CST will begin processing on the next business day.


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Service tasks¶
Each service embeds its own scheduling table. Some scheduled tasks are automatically configured:
- data synchronization
- resource information push to the collector
- service configuration push to the collector
- service and resource status push to the collector
- compliance run
Other tasks can be defined by the users.
Tasks Features¶
- tasks don't need to be added to the system's scheduler, thus can be provisioned along with the service
- tasks follow the service relocations
- tasks can can be disabled, scoped, unscheduled
- tasks runs can be conditionned by a specific service state. Only run on the active instance of a failover for example.
- tasks can be run manually
- tasks can run impersonated as a specified user
- tasks can have cron-style schedule, anacron-style, networker-style schedule definition
Typical Use-Cases¶
- embed scheduled tasks in a failover service to not have to swith-over the cronjobs
- embed complex commands as scheduled or unschedule tasks to ease and secure their use (ex: backups of dockerized databases, run a dockerized mysql client with predefinited args)
Tasks Operations¶
Print a service tasks and their scheduling status¶
$ sudo svcmgr -s testmd print schedule
action last run config parameter schedule definition
------ -------- ---------------- -------------------
task#0 - task#0.schedule -
task#1 2016-11-28 04:01:00 task#1.schedule @10
Manually run a task¶
All service tasks
$ sudo svcmgr -s testmd run
One specific task
$ sudo svcmgr -s testmd run --rid task#0
All tasks with the backup tag
$ sudo svcmgr -s testmd run --rid task --tags backup


text: Vogue Couturier Design 968; ©1957; Simonetta of Italy - One Piece Dress and Jacket. The bodice front of the slim fitted dress extends below the waist-line and buttons to skirt. Zipper closing at centre back below oval neck-line. Short or ¾ kimono sleeves with arrow gussets. The semi-fitted slightly high waisted jacket buttons below wide notched collar. Three quarter length sleeves, kimono in back, set in at front. Novelty belt.


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Can Netflix Conquer Japan? Why Netflix Expansion Into Japan Matters
- Netflix is launching its streaming service into Japan.
- The adoption rate will be better than expected due to scale, pricing, strategic partnerships, and integration into both mobile and gaming devices.
- Furthermore, Netflix has much more scale when compared to domestic film producers, and has a content collection that will still appeal to 40% of moviegoers.
- Therefore, the barrier to competition while high still seems surmountable in the case of Netflix.
- The total addressable market for Japan is $4.26 billion.
Netflix (NASDAQ:NFLX) is one of the few companies that I have been eyeing very closely. Not so much because of the recent correction in the stock, or because it's gotten easier to own following the recent stock split, but because of the growth potential in international markets. Recently, Netflix announced its expansion into Japan, with the service to be released on September 2, 2015. The company is in a pretty solid position to gain market share, as a result of its partnership with Softbank, and the adoption potential due to the high penetration of broadband households. The company's introductory pricing is low even when compared to the United States with pricing starting at $5.40 per month, which is almost half the price of subscriptions in the United States. This is a part of a long-term strategy to gain trust and awareness from Japanese consumers, but over time the company will eventually raise pricing to improve both profitability, and the quality of its content collection.
Analyst forecasts vary, but relatively quick adoption seems like a pretty high probability due to the aggressive marketing tactics that Netflix uses to broaden awareness of its products, and the ability to market and sell the service via Softbank. Netflix is also very well integrated into game consoles, so broadening the over-the-top service into game consoles reduces friction around adoption. Softbank will also pre-install Netflix into any smartphone or tablets they sell, which further lowers the barrier of entry.
Beyond aggressive pricing, Netflix also has a very competitive content budget, and its content licensing of US-based titles will make the service relevant to Japanese consumers. Furthermore, the company anticipates that it will adjust its content spend to create more original content for the Japanese market specifically. The amount spent isn't exactly quite clear, but approximately 50% of all content on Netflix Japan will be domestic offerings. Given the global profile of Netflix, there's a lot of export potential for various Japanese titles, especially because the company is planning on expanding its service into both China and India. Therefore content creators, get the immediate benefit of investments into Netflix- branded originals, and international distribution via its global subscriber base. Therefore, Japanese film producers will eventually come around to the idea of working with Netflix, as Netflix compensates for production up front and provides immediate exposure to a global audience. Furthermore, the Japanese film industry has been stagnant due to a lack of investment, which opens the opportunity for larger competitors to destabilize pre-existing companies.
The language barrier between perhaps Japan and China can be overcome through subtitles or dubbing. Titles created for Japa have much more potential for success if exported into a Chinese market, versus a Latin American market. After all, while there are some demographic differences preferences on storytelling, historical events, and style are likely to be the same. Hence, U.S. titles have performed relatively poorly in the Japanese box office for a number of years, as a lot of high budget films aren't very compatible with Japanese viewers. That could change going forward, as Netflix's incentives are more aligned to create a film-viewing experience catered to Japanese viewers.
Why Netflix Expansion Into Japan Means So Much
According to the Motion Picture Producers Association of Japan, the film industry generated ¥207 billion in terms of revenue. Based on current exchange rates, the Japanese film industry generates $3.25 billion in terms of box office gross receipts. However, Japanese films make up 58% of gross receipts. In other words, Netflix's content mix will already appeal to 41% of moviegoers. Therefore, Netflix's strategy to integrate approximately 50% of Japanese titles into its subscription package while using its pre-existing content licensing agreements to provide the other 50% in imported films and shows gives the company unprecedented leverage when compared to competing offerings. Furthermore, the Japanese film market is relatively small when compared to the global film industry, which is projected to gross $88.3 billion in revenue in 2015, according to Statista database.
Japan has approximately 35.5 million broadband households, so if we were to assume market saturation the revenue potential is $4.26 billion (assuming $10/month subscription rate). In other words, Netflix alone has enough scale to compete with the entire movie industry of Japan, as the projected revenue contribution makes it worthwhile to invest into the market, as if they were already an established channel provider. Success in Japan will also determine the success in China, so the company will be investing aggressively into its Japanese debut.
Netflix has a content budget of around $1 to $2 billion not including the licensing of TV shows, so the company is going to be extremely competitive even when compared to well-established broadcast television stations within Japan. This is because Netflix has a better content delivery method, and a global pool of subscribers to fund in-house content development. While much of the investment is currently directed towards Western titles, the company is planning to shift more of its content development toward Eastern markets, which is why they had invested so significantly into the development of Marco Polo. To produce 10 episodes of Marco Polo cost Netflix $90 million, which is an amount that Japanese-based channel providers or movie producers won't be able to match. Furthermore, Netflix is releasing a second season of Marco Polo in January of 2016, and it will be a global release. The title will appeal very specifically to the Asian demographic.
The scale of in-house content in Asian-centric narratives is expected to increase considerably going into the 2016 Chinese launch. Furthermore, momentum will begin to pick-up in 2017 as Disney titles will be made available on Netflix. This will broaden global appeal due to the high levels of international box office success both Disney Studio and Pixar animations tend to generate.
To conclude, Japan is an ideal market for Netflix to enter into. It has the cash to strong-arm local content producers, and it has a proven business model that works across demographics and geographics. With investment and expansion concentrated in Asian markets between 2015 and 2020, the company will be able to sustain its expansion efforts. This implies that many of these isolated markets will eventually be rolled over by the well capitalized, web-based TV streaming model of Netflix.
You can also check out amigobulls' Netflix stock analysis for a quick look at the company's key fundamentals.


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|Current Title
|Most Senior
|26 May 1940
|Bishop Giovanni Benedetti
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|12 Aug 1945
|Bishop Dante Bernini
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|12 Aug 1945
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Buffalo Bills
Buffalo Bills news, rumors and injuries
Bills | Buffalo trades Cardale Jones
Wed, 26 Jul 2017 16:57:13 -0700
Buffalo Bills QB Cardale Jones was traded to the Los Angeles Chargers Wednesday, July 26, in exchange for a conditional draft choice.
Comment () | Share: | Source: BuffaloBills.com - Chris Brown
Bills | Colt Anderson on PUP list
Wed, 26 Jul 2017 13:04:14 -0700
Buffalo Bills FS Colt Anderson (foot) was placed on the Active/Physically Unable to Perform list Wednesday, July 26, because of a foot injury.
Comment () | Share: | Source: BuffaloBills.com - Chris Brown
Tue, 25 Jul 2017 07:54:22 -0700
Free-agent LB Sam Barrington (Chiefs), FS Bacarri Rambo (Dolphins) and OG Karim Barton (Titans) to undisclosed deals Tuesday, July 25. C Patrick Lewis and LB Anthony Harrell were released.
Comment () | Share: | Source: BuffaloBills.com - Chris Brown
Bills | Three defenders visit Bills
Mon, 24 Jul 2017 14:09:28 -0700
Free-agents DT Roy Miller (Jaguars), DT Leger Douzable (Bills) and DT Devon Still (Texans) visited the Buffalo Bills Monday, July 24, according to a source.
Comment () | Share: | Source: NFL Network - Ian Rapoport
Bills | Adolphus Washington pleads not guilty
Mon, 24 Jul 2017 12:06:07 -0700
Buffalo Bills DT Adolphus Washington pleaded not guilty Monday, July 24, to a misdemeanor concealed weapon charge.
Comment () | Share: | Source: ESPN.com - Mike Rodak
Bills | Sammy Watkins healthy for camp?
Sat, 22 Jul 2017 18:21:33 -0700
Buffalo Bills WR Sammy Watkins (foot) is expected to be close to 100 percent healthy when training camp begins.
Fantasy Tip: Watkins has injury red flags galore, but he has WR1 potential if he can actually stay healthy. When it comes time to draft a WR2, you may want to roll the dice on Watkins and his upside.
Comment () | Share: | Source: The Buffalo News - Jay Skurski
Bills | LeSean McCoy doesn't plan to slow down
Fri, 21 Jul 2017 20:27:46 -0700
Buffalo Bills RB LeSean McCoy said he still feels young and owes his longevity to his ability to avoid big hits.
Fantasy Tip: McCoy ranked sixth in the NFL in rushing last year and third in yards per carry, so he isn't exactly slowing down at age 29. He is set to lead Buffalo's run-heavy offense and should be a safe RB1 option this season.
Comment () | Share: | Source: The Buffalo News - Jay Skurski
Bills | Reggie Ragland has target weight
Fri, 21 Jul 2017 17:26:10 -0700
Buffalo Bills LB Reggie Ragland said his playing weight is not allowed to be over 255 pounds or he will be fined $600 for every pound he is over that target weight. He said he currently weighs 250 pounds.
Comment () | Share: | Source: Sirius XM NFL Radio - Alex Marvez
Bills | Anquan Boldin to visit Monday
Fri, 21 Jul 2017 11:17:46 -0700
Free-agent WR Anquan Boldin (Lions) is scheduled to meet with the Buffalo Bills on Monday, July 24.
Fantasy Tip: Boldin said earlier in the offseason he intends to sign right before training camp and hopes to do so with a contender, although the Bills really don't meet that qualification at the moment. The 36-year-old would provide a solid veteran presence and give the team a dependable pair of hands behind rookie Zay Jones and the oft-injured Sammy Watkins.
Comment () | Share: | Source: ESPN.com - Dan Graziano
Bills | Zay Jones impressed during spring
Fri, 21 Jul 2017 09:19:34 -0700
Buffalo Bills second-round WR Zay Jones "performed well in spring practices" and "looked the part of a top-three wideout," according to BuffaloBills.com contributing correspondent Jake Hamilton.
Fantasy Tip: The Bills may very well may need Jones to be their top receiver for multiple games this year given Sammy Watkins' injury history. With that said, the rookie has some of the best hands of any receiver to come out of the draft in recent history and broke the FBS record for most receptions ever with 399 in his four-year career. Jones is a WR4 with WR3 upside, particularly if Watkins misses some games in 2017.
Comment () | Share: | Source: BuffaloBills.com - Jake Hamilton
Bills | Shaq Lawson impressive
Tue, 18 Jul 2017 20:02:22 -0700
Buffalo Bills DE Shaq Lawson has looked "fantastic with his hand in the ground coming off the edge so far," according to fellow defensive end Jerry Hughes.
Comment () | Share: | Source: Sirius XM NFL Radio
Bills | LeSean McCoy excited for offense
Thu, 13 Jul 2017 18:13:17 -0700
Buffalo Bills RB LeSean McCoy said he is excited about the zone running scheme offensive coordinator Rick Dennison is implementing this year. "With this offense they give you different options whether it's inside or outside," McCoy said. "When you want to stretch it, you can stretch it just enough to get the DBs where you want them so you can cut inside."
Fantasy Tip: Coming off a season when he ran for more than 1,200 yards and scored 14 times, McCoy is again set to be the lead back in one of the best rushing offenses in the league. Pencil him in as a dependable RB1.
Comment () | Share: | Source: BuffaloBills.com - Chris Brown
Bills | Matt Milano may have limited role
Wed, 12 Jul 2017 11:32:10 -0700
Buffalo Bills LB Matt Milano may only be used in obvious passing downs this season because he only weighs 223 pounds at this point and could be overmatched by opponent's running games.
Comment () | Share: | Source: BuffaloBills.com - Canio Marasco
Bills | Ramon Humber may not have size to start
Wed, 12 Jul 2017 11:26:11 -0700
Buffalo Bills LB Ramon Humber appears to be an unlikely candidate for one of the starting outside linebacker jobs because his size could make him a target for opponent's rushing attacks, in the opinion of BuffaloBills.com's Canio Marasco. He could become a nickel linebacker because he showed good coverage skills in the passing game.
Comment () | Share: | Source: BuffaloBills.com - Canio Marasco
Bills | Gerald Hodges worked on strong side
Wed, 12 Jul 2017 11:21:23 -0700
Buffalo Bills LB Gerald Hodges lined up mostly at strongside linebacker during offseason workouts and has a chance to win one of the starting outside linebacker jobs during training camp.
Comment () | Share: | Source: BuffaloBills.com - Canio Marasco
KFFL: Sports Link of the Day
Buffalo Bills Player News


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Each month, Rated People connects over 50,000 homeowners with quality tradesmen - simply enter your job details in the form above to get started.
We'll match your job to the relevant tradesmen in your area - those interested will pay to see your contact details and call you to quote.
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Added 12/12/2014
*Updated Lead* Changed information:description Replace kitchen sink tap, insert in-line valve,...
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I am looking for a tradesman to knock down an inside wall. Also might need advice on other...
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Added 21/03/2014
Services required: build raised beds, create borders, lawn seeding, paving, pergola/trellis...
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Dripping pipes on water tank needs fixing Also interested in advice for bathroom replacement...
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Re-roofing job to replace Blake tiles
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20x30m may need some scaffolding, not sure what materials to use.
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Managing your job is easier with the Rated People Homes App, download it today.


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FIT36 Franchise Muscles Into the Market With New Highland Studio
Sheryl Langley says FIT36 can make you look this good at 52, too.
courtesy Sheryl Langley
In a city of CrossFit "boxes" and 24 Hour Fitness locations, the FIT36 franchise has managed to muscle into the market. When she discovered FIT36 last summer, Sheryl Langley fell in love with the workout — and the results. She's gone down three dress sizes and says she looks better now at 52 than she did at twenty. She's also found a new career: On Saturday, February 20, she'll open a new FIT36 location at 3774 Julian Street.
Langley says the high-intensity interval training (HIIT) workout is a cross between CrossFit and Orange Theory Fitness, including the best of both regimens in just 36 minutes. "The difference with Orange Theory is they circuit in treadmills because they have a larger class and just one trainer," she explains. "We have two trainers with a max of 24 people in the room. We work to keep the heart rate up while working muscle groups so it's more efficient, burns more calories and more fat, and works a lot more muscle groups."
FIT36 is coming to the Highland neighborhood.
Courtesy Sheryl Langley
FIT36 offers more supervised training periods so that people are kept busier, she adds; the HIIT workout involves one minute going "full blown" and then thirty seconds of rest in between. "FIT36 involves a lot of energy and a lot of fun, because you have twelve stations, you go around twice and then you're high fiving and done," Langley says. "It's really impressive what you can get done in just 36 minutes. You don't have to think, you work your hardest, you get your results at the end of the class and see the calories burned, and then you're done."
While FIT36 offers modifications for the workout, Langley cautions that it's probably not for beginners. "As long as someone has a reasonable amount of fitness, they'll be fine," she says. "You don't have to be an athlete or anything; this workout is designed to elevate and move up pretty quickly."
Twelve stations make up FIT36.
Courtesy Sheryl Langley
The motto for her new studio is "training to live," Langley notes. "The studios that we have opened have seen tremendous results in terms of inches and fat loss, as well as being able to do a lot more in life," she adds. "FIT36 is for people who want to train to live, want to live longer, ski more, run and hike longer and just do their living."
"I look better at 52 than I did at 20."
Courtesy Sheryl Langley
As an incentive for Denver residents to try FIT36, Langley is offering a free ten-day trial membership from February 20 through February 29 for anyone who pre-registers today. The price for a monthly, unlimited membership will be $129, and a pack of eight classes will be $79. The first 36 people to purchase a monthly, unlimited membership will receive a free Polar Heart Rate Monitor to track their stats during the class. ("Loaner" heart-rate monitors will be available at each class, though Langley encourages people purchase their own.)
For more information about FIT36, visit fit36fitness.com; call 720-921-7928 to register for a class at the new Highland location.
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|Methods and compositions for the treatment of gastrointestinal disorders
|Methods, for the treatment of humans and lower animal subjects having a gastrointestinal disorder, comprising administering bismuth and administering an antimicrobial. From about 50 to about 5000 milligrams of bismuth are administered, per day, for from 3 to 56 days. A safe and effective amount of antimicrobial is administered for from 1 to 21 days. Preferred processes also include a step for performing a diagnostic test on the subject for detection of a campylobacter-like organism infection of the subject. The invention also provides compositions containing a safe and effective amount of bismuth and a safe and effective amount of antimicrobial.
|Marshall; Barry J. (Charlottesville, VA)
|The Procter & Gamble Company (Cincinnati, OH)
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Braun Beard Trimmer
Braun Beard Trimmer
Braun Beard Trimmer
Braun beard trimmer BT5070 with precision dial for up to 25 exact length settings to create your own individual style.
- 2 click & lock trimming combs make precise grooming and trimming easy
- Slide & style system. Style with the comb on
- The unique slide&style system lets you style your beard with a simple slide even when the comb is on
- Dual battery system. Powerful performance, cordless or corded
- Fully washable - the Braun beard trimmer is fully washable for easy cleaning under running water
- A full charge takes 1 hour and gives you 50 min. Of cordless performance. A 5 min. Quick charge is enough for 1 trim
- Manufacturer Warranty: 24 months


text:
|Home > Aegidia
♀ Aegidia
What does Aegidia mean?
Aegidia [aegidia] as a girls' name has its root in Greek, and Aegidia means "small goat". Aegidia is a variant form of Egidia (Greek): Latin feminine version of Giles.
VariationsCREATIVE FORMS
(female) Aegid, Aegida, ..
(male) Aegidi, Aegiti, .. MIDDLE NAME PAIRINGS
Aegidia Marisa (A.M.), ..
How popular is Aegidia?
Aegidia is an unusual first name for women. Aegidia is an equivalently unusual surname too for all people. (2000 U.S. CENSUS)
Aegidia has not been recorded in the Top 2000 thus far. (2015 BIRTH Statistics)
Similar NamesRecommended names are Abida, Acadia, Adelicia, Adia, Aeeda, Aegeria, Aegina, Aeisha, Aemelia, Aemilia, Aemilie, Aeriela, Agacia, Agilina, Aglaia, Aisia, Alaida, Alcinia (see Alcina), Alegria, Alida▼, Alidia, Alisia, Alitia, Allicia, Allida, Allidia, Allidiah, Aloisia, Alsinia, Alvinia, Amadia, Amelida, Amilia, Angelia▼, Angila, Anitia, Annida, Arcadia, Ardia, Argelia, Armida, Attilia, Availia, Begonia, Benicia, Cecilia▲, Ceilia, Celicia, Cericia, Delicia, Felicia▼, Gelilia, Genisia, Hedia, Heladia, Keicia, Kekilia, Leticia▼, Letitia▼, Letizia, Levinia, Lidia, Media, Melicia, Melitia, Melodia, Needia, Negida, Nidia, Reginia, Segovia, Sesilia, Venitia, Vigilia and Viridia. These names tend to be more commonly used than Aegidia.See names in meaning and etymology.


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SoftProdigy's Latest Offering - Ajax Add to Cart with Fly Effect Magento Extension
Simplifying the product purchase process for visitors of an online store has been SoftProdigy'
Understanding the needs of the customers, SoftProdigy has recently launched the Ajax Add to Cart with Fly Effect Magento Extension. This unique extension allows a user to add products to cart from the category page itself. This not only makes the entire shopping experience simple, but also helps a visitor save time while purchasing products without having to go to each product's individual page. Adding products from the category page also serves the advantage of making purchase easier in cases where a large number of products are to be purchased. This extension makes it possible to shop for products on the go and make shopping convenient. The extension is complete with nice graphics, and armed with better user interaction and interface. The user may move directly to the checkout page, or continue shopping. The extension is flexible in terms of options. AJAX is used in the extension to add products to cart. The best feature of the extension is that it is compatible on the mobile as well and is highly customizable.
Download Ajax Add to Cart with Fly Effect here: http://www.softprodigy.com/
The extension is selling like hot cakes in the online community already and generating raves. The team at SoftProdigy has had a great response so far and is happy with its success.
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Ping Women's Faith Fairway Wood
The PING Women's Faith Fairway Wood is designed for golfers with slower swing speeds and is much easier to hit than most long irons. Shallower head and deep CG allow for higher launch conditions. The CG is also slightly higher in the club head to produce more spin and higher launches. More solid contact and confidence is promoted by the larger effective hitting area on the club face.
Women's Faith Fairway Wood Features:
- Women's Fairway Wood
- Right and Left Handed
- Available Shafts: ULT 200 - Ultra Light, TFC 169 - Regular, ULT 129 - Ultra Light
- Available Flex: Ladies
- Available Lofts: Fairway Wood #5 - 22°, Fairway Wood #7 - 26°, Fairway Wood #9 - 30°
- Headcover included
- Ping


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A Back Road Traveler's Alaska
Photography by Michele Cornelius
by .
About the Book
Features & Details
- Category Arts & Photography
Standard Landscape, 10×8 in, 25×20 cm
58 Pages
- Publish Date Feb 10, 2013
See More
About the Creator
Michele Cornelius
Homer, Alaska
An ardent environmentalist living in Alaska, I work to capture the beauty of nature and other interesting things with photography and use these elements in digital art.
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Encontrar uma cópia na biblioteca
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|Formato Físico Adicional:
|Online version:
Yule, Andrew.
Sean Connery.
New York : D.I. Fine, ©1992
|Pessoa Denominada:
|Sean Connery; Sean Connery; Sean Connery
|Tipo de Material:
|Tipo de Documento
|Todos os Autores / Contribuintes:
Andrew Yule
|1556112777 9781556112775
|Número OCLC:
|Includes index.
|vi, 325 pages : illustrations ; 24 cm
|Andrew Yule.
Historian, takes the reader through Connery's years in British theater and television to his present-day super-celebrity status. Connery's breakthrough as James Bond established him as a potent "sex symbol," but his determination to shake the Bondian typecasting led him to hits as diverse as The Anderson Tapes and The Man Who Would Be King. Well-regarded but unsuccessful ventures in the late 1970s and early 1980s left him broke, but when it seemed his career had run its.
Course, Connery was back, larger than ever, with an Oscar-winning performance in The Untouchables, and roles in such successes as Indiana Jones and the Last Crusade and The Hunt for Red October. Sean Connery emerges here, the author suggests, as a minefield of contradictions: happily married, with a legendary history of conquests; easy-going, yet remarkably unforgiving. Interviews with Connery's friends, foes and the women he has known - as well as with directors of some.
Of his most memorable films, including Sidney Lumet, Terry Gilliam, Richard Lester and Fred Zinnemann - result in a wonderfully frank, unflinching portrait of one of the world's most formidable, skilled and complex superstars.