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Pete Souza, the Chief Official White House Photographer, just posted a huge album of all of the many wonderful shots he has taken with his iPhone over the last year.
Apple's latest acquisition could revolutionize iPhone camera
Apple is looking to ramp up its camera technology with the acquisition of Israeli company LinX.
The two companies reached a deal that will see Apple paying about $20 million for the startup, but if the company's multi-aperture cameras are actually as stunning as advertised, future iPhones could gain SLR-quality images.
How to use iOS 8 like a boss
You don't need a new iPhone to enjoy the awesome power of iOS 8. Loaded with new features and built-in apps, Apple's latest mobile OS is its most powerful yet.
As intuitive as it is, there are plenty of tips and tricks that will help you truly get the most out of iOS 8 — even starting before you pull the trigger on the free upgrade. Just in case you don't feel like reading all 182 pages of Apple's official iOS 8 user guide, here's a roundup of Cult of Mac's most helpful iOS 8 tips and tricks. (We will update this post as we dive deeper into iOS 8 in coming weeks.)
How to switch to iOS 8's iCloud Photo Library right now
[UPDATE: Lots of readers report that the new option to activate iCloud Photo Library isn't showing up on their devices. I'm looking into it. So far I know that the GM version — the one I used to write this guide — and the final version are identical, build number 12A365. My guess is that Apple turned off the beta already]
iCloud Photo Library is rad. The idea is that all your full-res photos (including RAW photos) reside on Apple's servers, and you access them from all your devices.
That's a change from Photo Stream as it is now, which stores only the last 1,000 photos you took, not your whole collection. Apple has also introduced new tiers of iCloud storage pricing to cope with all your photos (and videos). This is now live, and I signed up for the 200GB option ($4 per month) to test it out.
Let's take a look.
iOS 8 gives the Photos app superpowers
Photos on iOS 8 are so good that you will be able to ditch a whole home-screen folder's worth of editing and organizing apps. That's not an exaggeration: Apple's new mobile OS packs in so many great new features that – even without the extending abilities of iOS 8's new plug-ins – you can do pretty much any edit right there in the photos app.
The camera, too, has gotten an upgrade, and – maybe the most important for some – so has the iCloud Photo Stream, which will now give access to all your photos, from any device, whenever you want.
Sounds pretty good huh?
ProCam brings iOS 8's manual camera controls into focus
ProCam 2 – confusingly now at v3.0 – is the first camera app that allows manual focus and exposure on devices running iOS 8. You now get full manual control of ISO, shutter speed, focus and white balance, all with neat-o on-screen sliders.
The iPhone 6 camera is the only camera you need
Two things strike me about the camera in the new iPhone 6 models. One is that you can take better pictures; the other is that the iPhone is now a much better place for viewing those pictures.
With their bigger, brighter screens — and iCloud's new Photo Albums feature (which stores all your photos, ready to view, in iCloud) — the iPhone 6 and its larger sibling, the iPhone 6 Plus, are looking to be the best smartphones yet, from a photographic point of view.
How to create and use custom presets in Lightroom Mobile
I can't tell you how much I love Adobe's Lightroom Mobile. But like an insatiable lover, I want more. Specifically, I want to add my own presets. LR Mobile ships with a selection of the desktop app's image presets built in, but unlike the desktop version, you can't save your own settings as a preset, nor can you add any made by third parties. Or can you?
In this tutorial, we'll see how to add any preset to Lightroom Mobile, using any and all of the image-editing tools available in the Mac version and making them available on iOS.


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Use WordPress On Your Android Smartphone or Tablet
WordPress is most popular platform for bogging, it's free and open source blogging platform that based on PHP and MySQL. WordPress has lots of useful features such as plug-in architecture, template system, themes, plugins and all gadgets of all strips, it's much easy to use and fast, it has great reputation because it's really useful. WordPress offers thousands of free themes, it also offer some paid themes, you can create plug-ins, it's best for those who write more long-form posts and create a more traditional blog without too much effort.
WordPress apps are also available for iPhone, iPod touch, iPad and Android that allows you to use WordPress on your smartphone or tablet. With WordPress app you can write new posts, edit content, and manage comments on your WordPress blog, it's open source app that allows you to write posts, edit content, view stats, and manage comments with built-in notifications.
As I said above that it's much easy to use and fast, to use the app first you'll have to configure your WordPress blog, to do it, just open the WordPress Admin Panel by heading over to www.yourdomain.com/wp-admin, there replace yourdomain.com with your own domain name, then navigate to Setting followed by Writing and check the box Enable the WordPress, Movable Type, MetaWeblog and Blogger XML-RPC publishing protocols.
After above requirements as you configured your WordPress blog, you'll have to configure the WordPress, to do it, open WordPress app, from the main menu of app select the third option "Add self-hosted WordPress blog" then enter the requires details such as blog URL, username, password and tap on save button, below screen will appear.
That's it, now you can add posts, edit posts and view the stats. A useful app to use WordPess on your Android smartphone or tablet. The WordPress app requires Android 3.0 and above, it's completely free app, you can download it from below link and do let us know about this WordPress in below comments:
WordPress [Google Play Download Link]

subset: commoncrawl


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Subscribe to our notifications so you don't miss out on our new sales!
36 x Cadbury Marvellous Creations Jelly Crunchie Bits Bars 50g
Get your chocolate fix with a twist and snap up a box of Cadbury's Marvellous Creations bars. Made with their signature milk chocolate, each bar is packed with flavoured jelly pieces and honeycomb Crunchie bits. Grab your stash and save!
- Cadbury Marvellous Creations Bars
- Pack contents: 36 x 50g bars
- Flavour: Jelly Crunchie Bits
- Smooth Dairy Milk chocolate
- Flavoured jelly pieces & honeycomb Crunchie bits
- Great for sharing with friends & family!
- Country of origin: Australia
- Best Before: 06/09/2016


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Book Notes: Standing Apart: Mormon Historical Consciousness and the Concept of Apostasy
In my estimation, Standing Apart is the most important Mormon studies book since Bushman's Rough Stone Rolling. Read more to find out why.Read More
In my estimation, Standing Apart is the most important Mormon studies book since Bushman's Rough Stone Rolling. Read more to find out why.Read More
Latter-day Saints have always had a complicated relationship with the Bible. Joseph Smith signaled his deep reliance on the holy text even while challenging its authority. While he accepted many of his era's common assumptions about the Bible, he also emphasized that it was only true insofar as it was "translated correctly." He made revisions through prophetic inspiration but also labored to learn Hebrew in […]Read More
The Joseph Smith Papers project is so fruitful that some scholars are harvesting fruits from particular volumes before they've even been published. Such is Sustaining the Law, a collection of papers addressing the legal side of Joseph Smith's multifaceted life. The book's three editors began its compilation while working on the Joseph Smith Papers Project's Legal and […]Read More
BYU scholars of the Bible and religion in antiquity are often, perhaps even distinctively, drawn to the fundamental work of their disciplines such as archaeology and textual editing. These are certainly high-value activities that result in primary contributions to research. It is unfortunate that their specialist character may render them less known to nonspecialist readers, […]Read More


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James Santiago Photographer
mayleena smithModel Female Vista, California, US
My MM URL: http://www.modelmayhem.com/mayleenasmith
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About Mehello my name is Mayleena i take my work very professional im a hard worker and a fun person to work with im easy going and i only do payed work thank you so if interested in pleas message me on here and we will talk into further details looking fw to working with you guys :]
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Waking throughout the night with tingling and numbness in the hands can be exhausting and frustrating, especially if it occurs on a regular basis. Since these sensations can be caused by a variety of medical conditions, determining the underlying problem is the first step to receiving appropriate treatment and eventual relief.
Carpal Tunnel Syndrome
The carpal tunnel is a narrow passageway in the wrist through which tendons and the median nerve run. The median nerve is responsible for motor and sensory functions in the thumb, index, middle and ring fingers. Anything that increases pressure on this nerve causes carpal tunnel syndrome. Pain, tingling and numbness can radiate from the wrist down to the hand or upward to the arm, eventually leading to weakness in the hand, loss of grip strength and the tendency to drop objects. Carpal tunnel syndrome can result from injury that causes swelling in the wrist, fluid retention due to pregnancy or other medical conditions, such as diabetes, rheumatoid arthritis, hypothyroidism or hormonal disorders. The most prevalent cause, however, is repetitive flexion and extension of the hand, especially when done forcefully, for long periods of time.
Cervical Spondylosis
Cervical spondylosis is a condition resulting from age-related wearing of the vertebrae in the neck, generally occurring after the age of 40. The deterioration of bone and cartilage may cause bone spurs (growths) to form on the vertebrae that can compress nerves, causing pain, stiffness and muscle spasms in the neck, shoulder, arm, or chest. Numbness, weakness and tingling may be experienced in the arms, hands, legs or feet. Additional symptoms include a lack of coordination, difficulty walking and abnormal reflexes.
Thoracic Outlet Syndrome
The thoracic outlet is the small area between the collar bone (clavicle) and rib cage through which blood vessels and nerves pass on their way to the arms. Compression on the nerves or blood vessels can cause numbness, pain, weakness and tingling in the middle, ring and little fingers and in the inner forearm. Pin-prick sensations may also be felt in the neck and shoulders and are often triggered by carrying heavy objects. Thoracic outlet syndrome can result from the presence of an extra cervical rib or tight chest or neck muscles. Typically, individuals suffering from this condition have a history of a shoulder injury or overuse of the shoulder.
Peripheral Neuropathy
Peripheral neuropathy is a disorder in which the nerves of the Peripheral Nervous System (PNS) are damaged. Symptoms are dependent on the type of nerves affected. Sensory nerve damage causes pain, tingling, numbness and burning sensations, while motor nerve damage interferes with muscle control and causes cramps and weakness. Peripheral neuropathy can be caused by disease of the nerves themselves or by other illnesses such as diabetes, alcoholism and rheumatoid arthritis. Other possible causes are nutritional deficiency, lead or mercury poisoning or the presence of tumors.
Cubital Tunnel Syndrome
The ulnar nerve passes through a bony passageway behind the elbow called the cubital tunnel. Hitting your "funny bone" is actually hitting your ulnar nerve. Pressure or irritation to the ulnar nerve causes tingling and numbness in the last two fingers and the palm. Numbness is generally triggered by keeping the elbow bent for long periods of time. Most often, cubital tunnel syndrome occurs as a result of injury to the elbow from fractures, dislocation or twisting, but may also result from work requiring repetitive elbow flexion.
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An Year Ago we started to play Live Shows in France, since then we've played more than 30 Shows in France and Abroad, Sonar, Montreal Jazz Festival, Fusion… Big up to «Rencontres Trans Musicales de Rennes» who made this possible. We've uploadet the full Show from last Year on Youtube. The show was filmed and broadcasted live by Arte Web TV:
Big Up!
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You will really like to have online assistance of the customer care executives who are ready to register your services with the escort of your choice under schedules dates.
Formal sites of the KL escort industry are there to offer you detailed information regarding KL escort services.
Customer care executives there are ready 24x7 hours to listen to from you and avail the lady of your choice for outstanding fun.
So, whenever you are willing to get custom escort service, you need nothing but explore the official website of the escort industry to know details in this direction.
So, are you ready to check out those hot and sensual divas online to make your boring life adorable?
Before selecting any agency for the service, people should check working style of the agency as well as the girls working with the agency.
As agencies operate through the website, people can check the websites for various reviews and comments left by the other people who have already used their services in the past. This will help people to select the right escort service provider like escort girl agency Kuala Lumpur.
Check the price range: Most of the agencies offer various price ranges for the various services they offer as well as various girls working with them. People can find a service that can suit regular people to the high-class people. Some of the agencies even take care of your accommodation for several days along with allocating the escort for that many days with you like Malaysia escort agency.
Check for any additional charges: People should also check for any additional or hidden charges. If customers are not able to see any price list on the website, they can contact the agency directly through the telephone or email or fax. There are many people who have used the services from some agencies, but then later regretted it because of additional charges from the agencies.
Malaysia is a marvelous place to visit as it features with a host of tourist places and hot girls. For those who wish to enjoy in full freedom, Kuala Lumpur can be a go to destination for them, as the city has a plethora of must see places and also features with hot babes who can add more pleasing.
It is a heavenly place for those who want to have pleasure with young and sexy women out of their relationships. If you happen to be in Kuala Lumpur and wish to enjoy with hot and sexy babes, you can utilize the Kuala Lumpur call girl service.
The escort girl Kuala Lumpur is well trained and has an attractive and sexy, who will make sure that you have a delightful time when you are with her.
When you invite a Kuala Lumpur escort girl to come spend some time with you, you are not only getting a sure thing, you also get to enjoy her company in public as well.
Go for a dinner, or enjoy the nightlife of Kuala lumpur with your escort model. With someone local showing you around, you will get the most out of your visit to Malaysia.
How often have you wished that you could avoid all the tourist traps and see the real face of a country? How many times have you reached a country, only to find hordes of crowd blocking the view everywhere and making it impossible for you to enjoy yourself?
Just ask your date to show you the real Kuala lumpur, and forget about all the hyped up places. Whether you want to shop for souvenirs, or sample the local cuisine, the Kuala Lumpur escort girl can show you the best places in the city that tourists do not know about.
Discover the rich culture of Malaysia, find out everything about Kuala lumpur, and on top of all this, also get to enjoy the pleasure of the company of an insanely hot woman.
Whether you are native or you are planning a short trip to London, you need nothing nut to check out the team of available escorts in the industry online.
It is the best way to find out that who is the beautiful courtesan you are interested in. You will get detailed information about all the escorts regarding measurements, body size, service orientation and background.
On basis of this information and alluring pictures of the escorts, you can understand that which girl you are willing to make your companion in bedroom.
One of the most amazing things about London Escorts is that there alternatives can be registered online as numerous well certified customer care executives are ready to serve you whenever they feel requirement of supporting you. No problem, what are your goals or what kind of lady you want for, the team of expert customer care executives is active enough to materialize your love fantasies with the amazing lady you want. In this way, it becomes simple for you to enjoy an unforgettable session with the sensual London girl.
The big mistake that men make is to fall for a wrong girl. While when you choose a Russian escort in KL, you will be able to have your dream girl and enjoyment. Due to psychologists the regular sex can help you in relaxing. The article below will help you to find a dream girl with great enjoyment. Hiring a Russian escort in Kuala Lumpur you will be able to enjoy your time.
There are a lot of services in Malaysia's KL and you should find your dream escort girl to have experience, full body massage, russian spas and so on with happy end. Most guys look for full escort services and that's why it's important to find good KL's Russian escorts who know how to create a great time to you.
You can visit websites of right escort agencies like Penthouse escort agency and choose a female russian escort by photos that definitely will help you to find the right Russian escort girl.
You need to know what exactly you would like from Russian escort girl, which services for your enjoyment in KL. Russian escort can behave well with you and because of it you won't even be able to end up your losing side. If you can you must inquire into all escort services and you will be the gainer.
After an exhausting day of leisure or work in the stylish Singapore why not brighten up your evening with some very hot female attention?
If that is exactly your best way to relax, invite a Katong call girl in and have all the possible sex pleasures delivered to you without the need to even raise a finger!
Imagine a scorching hot and naughty-looking blonde with big and firm boobs coming to your hotel room and starting to show her beauties, slowly seducing you and making you totally horny with just the looks. And then she starts using her tender and skillful hands on you, together with that wet and sensual mouth of hers, and now you are already dying from passion.
And when she finally sates your lust the way you have only dreamt of in your most daring erotic fantasies, you simply explode with pleasure, forgetting the whole world in this wonderful sensation. That's what time with a Katong call girl feels like!
And if you are staying in Singapore, you have a wonderful chance to have this kind of experience of your own!
On your stay in Singapore you might need some company and advice from a local: where to go eat, dance or gamble, what the local peculiarities in all spheres of life are and many other things.
Local escorts provide you an amazing opportunity to combine it all with hot female attention from a really gorgeous lady. Here you can hire best girls in Singapore ready to be your guides, companions, advisors and lovers for as long as you want them to.
Of course, personal escorts in Singapore are not just friendly conversation and pleasant company to hang out at a club or casino. Local escorts provide superb sex services, too!
These curves and beauties are not just for you to look at, but to touch and possess whenever and whichever way you want!
Escort ladies have perfect skills and amazing appetites, and they are eager to get involved into any kind of sexual practices you might suggest, no matter how nasty or daring. Here in Singapore personal escorts are a true key to a happy and memorable stay in the city!
Female Escort in Malaysia is very fashionable and extremely popular today among men around the world who are interested in chic girls. You have the opportunity to get an incredibly fine impression of a professional escort. Well-trained girls turn your holiday in Malaysia to the real east fairy tale with a sexual piquancy.
Historical traditions of this country teach women to give men sensual pleasure and realize their dreams. That is why this part of the world is so popular. Every year more and more famous, rich men come to Malaysia to get the joy from unusual and charming women of the East.
Of course all women understand the feelings of their customers. So your will be confidential.
Girls with soft and sensual character would be wonderful companions at parties or even business meetings. They will open you a wonderful world of love and sexual sensuality. They know a wide variety of moves and ready to use it by exploring your body step by step. Just select a girl online and enjoy the sensual communication with her.
If your stay in Singapore is becoming blander and blander simply because of your craving for female sexual attention, or you just want a thrilling one night stand with a local chick, pay your attention to Kallang adult dating service. It will be most convenient if your accommodation is situated in southeastern part of Singapore - Kallang, as locality matters much in adult dating, still there you can find partners from different parts of the city.
Yet even a better way into spicing up your nights in Singapore than Kallang adult dating is local escort service.
Girls there are more attractive, looking like real beauty queens sometimes, and they are eager to have sex with you straight away, without any social rituals and in all ways and positions.
From this point of view Singapore provides perfect opportunities to satisfy your secret desires and make your most daring erotic fantasies come true. Be it adult dating or sex escorts, Singapore provides lots of ways to make nights spent here exciting and memorable!
Kuala Lumpur is a beautiful city with a lively ambiance and a dazzling nightlife and being one of the important entertainment hubs and tourist attractions, this destination also features some of the top escort service agencies offering great treats for the clients looking to enjoy their Kuala Lumpur experience with a difference.
Giving you the ultimate dose of fun and entertainment, these escort agencies hire the best looking divas who are aptly trained and groomed to satisfy their clients in every possible manner.
These escorts are sourced from the various Asian countries and they are mostly well educated and have a proper understanding of their profession, market requirements and client expectations so as to create their services accordingly.
These girls are smart, witty and fun loving while keeping their clients completely satisfied with kinky and sexy acts. These girls with a shy yet have a strong personality, know how to calm their clients when they are troubled and upset.
The basic of concept of escort services has changed greatly over the years and presently, the model escorts understand their business perfectly so as to make their clients happy and keep them engaged with smart chitchat and conversations.
These are interactive girls who know exactly how to entertain their clients with both sex and engaging conversations, in order to help them relax and release stress. A great way to de-stress the clients is through full body massages and relaxing soothing music that not just rejuvenates your senses but also arouses your sexuality for a fulfilling and intriguing session of sex and fun.
If there's something truly amazing to visit in Malaysia that is its lesbian clubs. Only in Malaysia you get to see so many and so astounding clubs of such kind, ready to welcome you with truly unique experiences. If you need to make your trip to Malaysia a truly remarkable one than you should definitely go to Taman Duta Club Lesbian, a hot place in KL which will make you feel astounding.
Either you are here for business or for a stunning vacation, exploring this lesbian club will surely make you feel perfect. It's stashed with beautiful girls, all needy and horny to play naughty and pose their nude forms while having fun with other girls.
This is the best way to release the stress and enjoy some quality time, by joining Taman Duta Club Lesbian the best place for full leisure and relaxation.
Hot beauties with sexy nude forms in great need to lick some pussy and provide sweet masturbation scenes which will give you high sensations as well as great stimulation to your dirty thoughts. Check out Taman Duta Club Lesbian the only place in Malaysia to provide total discretion along with high class services.
Park your exotic car and step into Damansara Utama Club Lesbian where exquisite women find fellow hot babes and party like itb s their last day on earth. Experience a unique but rare feeling of comfort elevated by a very attractive lesbian with all the attributes you love. Asian lesbian babes are truly gifted with striking beauty and elegant eyes.
These marvelous ladies will provide a true girlfriend experience as you revel with them at Damansara Utama Club Lesbian. The design and discrete location of these nightclubs depicts the kind of quality service rendered. Enjoy partying with hot women having the potential to offer ultimate pleasure and satisfaction.
Damansara Utama Club Lesbian allows you to experience true girlfriend experiences with fine open minded lesbians, respectable and reputable. Stay happy always and whenever you feel down, this is the place where fun enthusiasts are generous enough to share their joy and glee.
Party in the friendliest and hospitable gay bar in town and interact with diverse intelligent good looking women. Taman Setiawangsa Club Lesbian welcomes all visitors from different parts of the world but offers them a unique entertainment package that gratifies fully. If you know what you want, this is the perfect place where you meet that dream girl that completes your sensual desires.
The mammoth crowds that throng this safe entertaining paradise a pure turn on for fun enthusiasts. Taman Setiawangsa Club Lesbian does not have a secret ingredient for attracting elite lesbian beauties, but a big heart to accommodate you and many more women who love partying, drinking and hot lesbians.
Designed to uplift and mask your self-esteem with unmatched confidence, enjoy your priceless time with some rare magnificent beauties with enticing appeal. Taman Setiawangsa Club Lesbian never lets you down but gets you down to what you love and cherish most.
If you have a taste for high quality then you will have to approach elite Kuala Lumpur escort agencies that will have the right mix of experience and expertise to help you have a great time.
An escort service can be termed elite if it can provide you with high quality escorts who are aware of what you need. Most of the elite Johor escort agencies will have very few escorts working with them, as they tend to focus on quality rather than quantity.
The screening process that is involved while selecting escorts for the agency is usually very strict and this ensures that the customers will only be provided with some of the best escorts in the business.
In Malaysia various scams and fraud escort agencies working in Kuala Lumpur but you must stay away from them. Hire a Malaysia escort which is ready to go out with you in one of your business meetings abroad. If possible, you must try and ask them about some legal assurance so that you are able to look out for some fine alternatives.
Escorts in Malaysia will definitely make your stay a memorable one and by looking out for some quick options you can definitely spend some romantic hours with the ladies.
One of the most significant things that you should remember here is the fact that generating quick results can only become possible when you work with exceptional agencies like Penthouse escort. These kinds of professional names in the Malaysian escort agency will allow you to find gorgeous blonde and brunette girls. Even if you want to hire an Asian beauty then you could easily do so by hiring a company like this.
So, what are you waiting for? Go ahead and choose the right escort agency in Malaysia which will allow you to have great fun during your trip to Malaysia. These gorgeous girls will definitely help you in making your stay worthwhile! Enjoy yourself!
Taman Mayang Club Lesbian prides with its famous beautiful lesbians who fancy partying and spending time with sophisticated women. These alluring hot ladies have what it takes to ensure you are thrilled and relaxed all night long. Their open minds and welcoming hearts is a plus for their raging reputation.
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Enjoy endless conversations with lesbians drawn from diverse Asian countries with dissimilar cultures. The good thing with Taman Mayang Club Lesbian women, is that they are well educated and urbane, their social skills are top notch hence their charming capabilities.
Have you any hard time and cannot cope with it? How do you think, can woman of the best beauty help you in switching your condition to positive through lesbian services? Salak Club Lesbian presents the full list of the top country attractive lesbians.
Club guarantees that they take all your sorrow and negative mood far and durably away. Delicious black-hair ladies will make all that your life enjoyment never stops.
They don't speak with you without a need. They simply will do what they know best. But if they begin, you will be impressed. Really though they seem very calm, their talk is a kind of provoking you in the best lesbian service approach.
Their marvelous and alive tongues will give you the best pleasure you ever receive in your life. Providing lesbian escort, Salak Club lesbians are so free and vivid that the real entertainment presented by them will not leave calm even the most skeptic ones. If you love hot and welcoming creatures you should really visit Salak Club Lesbian. With them you never feel yourself bored. They make you reach a pick of pleasure. They are incomparable masters in it.
Welcome to Salak Club Lesbian.
After coming to our amazing resort and feeling an atmosphere of sex that reigns on this territory, a desire to try something unusual arises very quickly!
But at the same time this sense is capable to provoke even the most undercover desires. Who except a woman will understand what is necessary for another woman?
In that case our lesbians, these friendly, absolutely liberated girls will give you such carnal pleasure that you couldn't even imagine! These languid babies will bring you to the top of a paradise therefore you will be able to experience completely true.
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These attractive girls are capable not only to satisfy your requirement and dreams, but they also will excite you gently and tenderly pleasing each other! Watching their young bumping bodies, all new and new sweet desires will fill you.
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Kuala Lumpur - is the diamond of Southeast Asia, a place where people to take everything from life. Our agency offers you a stunning company of girls Slavic appearance from Russia and Ukraine. Burning beauty will help you pass the sunny days in this paradise planet.
If you come to rest or live in Kuala Lumpur and want some exotic and fire, please contact our agency. Here you will be served at the highest level. We guarantee that you'll be in seventh heaven. Russian beauty is famous not only for its appearance, but also intelligence, these girls - a good companion who is not ashamed to show your friends and business partners.
Erotic passion Russian girls is known around the world, and you feel it, choose among 300 girls who are represented in our agency. We'll bring the girls directly to your home, convenient service, with which you can leave out from your head all problems and drawn into sweet pleasure.
A lot of men dream about unforgettable experience from the company of beautiful busty women with a light character. The easiest way to find a girl is look for info and choose the web agency. And Malaysia is well known throughout the world by the most attractive, seductive, young women. Full info about outcall escort service you can find on our site.
You just may make your choice by viewing a wide variety of presentations in the pages of online agencies. Next choose a girl which for sure will happy to arrive at your destination in time when it will be convenient.
You may do with these girls absolutely all what you can image. They are ideal for the sensual pleasures which associate with the most intimate part of your body. These girls know how to tease and lure making a lot of playful movements when you are alone. You can't imagine how exciting to explore all of the most special parts of their body. These girls know how to make the most pleasure from your movements.
At the same time they are attractive and bright. You will be pleased to go with them to a bar or a party. Your couple will always be in the spotlight.
All the girls in the agencies are pre-selected. Therefore you can simply select and enjoy your choice.
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Faul said she and most of the parent were angry more about the timing of the announcement than the fact that buses will bring their children home about seven minutes later than in prior school years. "A lot of parents are angry because they didn't hear of the change sooner,' ' said Faul, president of the Center Grove School PTA. "If parents knew earlier, they could have made different schedules." The new schedules were announced by Schools Superintendent Karen Lake. The reason for the changes is to add 26 minutes in educational time in the 2001-02 school year to the high school day to approach the state average of five hours and 39 minutes.
The instructional day will be increased by eliminating home room periods, shortening the time between classes and extending the school day by 10 minutes.
The extended school day will have a ripple effect meaning school buses will bring children home later throughout the district. Lake said children will arrive ho me seven minutes later for the last buses from the Center Grove and Ironia schools.
Lake said the extended school day was a key in negotiations between the board and the Randolph Education Association. Negotiators for the two groups have agreed on a new three-year pact but the rank and file and the school board have not yet ratified.
Delay In Reporting
Lake said she could not report on the new schedules earlier because the rank and file did not know the details. However, though there had still been no vote, she said she decided to inform parents because school will be starting next week.
"The issue became one of how much I could say relative to the (tentative contract) that hadn't been shared with the Randolph Education Association membership,' ' Lake said. "Since we were starting school soon, I had to do something."
Lake said she is convinced of the need for more instructional time at the high school.
"If I erred on the side of trying to get as much instructional time as possible, I'm guilty," Lake said.
Lake said she estimated three-quarters of Monday's night's audience were concerned with the new schedule and were from the Ironia and Center Grove Schools, which will be most affected by the later bus runs. The balance of those in attendance supported extending the school day, Lake said.
Lake also said she had received more than 70 telephone calls from concerned parents last week.
The new schedule will go into effect in November if the contract is ratified this month or by early October. If the ratification is delayed, the extended schedule would be implemented in February, Lake said.
"Karen Lake's hands were tied by the negotiations," Faul said. "Parents are pretty upset but there isn't much they can do right now."
Faul said she approved of extending the high school instructional day and that the later bus runs were an unfortunate byproduct.
"Adding 25 minutes to the high school day can only help students," said Faul, whose two daughters attend Center Grove School. "Unfortunately, it's a chain reaction. I'm not crazy about it but for the better good, I can live with it."


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Since taking over as Director of Athletics at Campbell University in July 2011, Bob Roller has led a department that has reached new heights in academics, facility construction, fund raising and competition.
Roller's tenure has seen Campbell Athletics achieve its highest academic marks in school history. Campbell student-athletes have maintained an overall GPA of 3.042 over the past two seasons.
During that same period, 42 percent of Campbell's 480 student-athletes among its 21 NCAA Division I sports maintained an overall GPA of 3.25 or higher.
On the field, the women's golf team has won three Big South Conference championships (2012, 2014 and 2016) and competed in five NCAA Regionals and two NCAA Championships; the men's golf team competed in this year's NCAA Regionals; the men's cross country team won the 2015 Big South title; and the baseball team won the Big South regular season title in 2013 and the tournament championship in 2014, when it also earned a berth in the NCAA tournament.
Overall, Campbell Athletics' 21 Division I programs have seen steady improvement in competition. That culminated with Campbell's highest ranking in the Big South Conference overall sports trophy standings in 2016 since re-joining the league five years ago.
"I am most appreciative to Dr. Creed for his confidence and support in this transition. It been an amazing first five years working with Dr. Bazemore and the entire University Cabinet," Roller said. "Carolyn and I have loved becoming a part of the Campbell community and Buies Creek. The Campbell brand has grown considerably across our state and nation, and there is no reason to slow down. Our alumni and boosters deserve much of the credit for this growth as we have received tremendous support from these groups."
Roller has led a transformation of Campbell Athletics through major facility improvements and record fund-raising. Major facility additions and expansions he has overseen include:
- Installing a four-sided center hung LED display scoreboard and court-side LED scorer's table at the John W. Pope, Jr. Convocation Center, where the basketball and volleyball teams play
- Opening the Burt Family Sports Performance Center, adding lights and a LED display scoreboard and video board, and completing the West grandstand and press box at Barker-Lane Stadium, where the football and women's lacrosse teams play
- Renovating and dedicating Jim Perry Stadium, where the baseball team plays
- Dedicating the Irwin Belk Track and Clarence Roberts Field
- Renovating Eakes Athletics Complex, home to the men's and women's soccer teams
- Opening Amanda Littlejohn Stadium, where the softball team plays
In addition, Roller led the creation of The CAMMYs, Campbell's multi-media awards show for student-athletes widely recognized as one of the finest events of its kind. He also was instrumental in Campbell winning the bid to host the 2016 Big South Men's Basketball Championship. The 2016 event held in Buies Creek drew the tournament's highest attendance in the last five years.
During Roller's tenure, Campbell has also co-hosted the 2013 and 2015 NCAA Women's Soccer College Cup and the 2014 NCAA Men's Soccer College Cup, and hosted the 2015 Big South Softball Championship and the 2014 Southern Conference Wrestling Championship.
Under his watch, 900 of Campbell's NCAA Division I student-athletes over the last four years have recorded an overall grade-point average of better than 3.0 during the academic year.
Campbell athletes have also donated more than 18,000 hours in community service around the Buies Creek area over the past five academic years.
Introduced on July 20, 2011 as the fourth A.D. of Campbell's Division I era (since 1977-78), Roller joined the Fighting Camel staff after spending more than 11 years as Director of Athletics at Samford University. While at the Birmingham, Ala., school, he oversaw one of the most exciting periods of growth in the history of Samford athletics.
During his tenure at Samford, the entire facilities landscape of the campus was transformed. New athletics venues were built for men's and women's basketball, volleyball, baseball, tennis, soccer, track and field and a football field house and strength and conditioning center were funded and constructed.
Roller arrived at Samford in 1997 to direct the Samford Athletic Foundation. During his first two years, the foundation saw record growth in individual and corporate donations to the university's athletics programs. Roller held that position until May 1999, when then-President Thomas E. Corts named him to the top position within the athletics department.
In the summer of 2003, Roller was elected to the prestigious executive committee of the National Association of Collegiate Directors of Athletics [NACDA] to serve a four-year term. He joined athletics directors from Kansas State, Stanford, Army and Clemson on the governing committee that oversees the activities of the 6,000-plus member organization.
In 2006, Roller was named national chairman of the Learfield Sports Directors' Cup Committee for NACDA. The Directors' Cup is awarded to the top universities in NCAA Division I, II, III and NAIA for overall athletics success throughout the inter-collegiate season.
Prior to his tenure at Samford, Roller was vice president of AdCraft Sports Marketing in Louisville, Ky., for seven years. During that time, he helped create the Sears Collegiate Champions program, which honors all champions of men's and women's sports throughout the nation at every level of college athletics.
While with AdCraft, a division of Host Communications, Inc., Roller created and managed a publishing division and helped launch NCAA Football USA, which involved promotion, licensing and merchandising for college football programs at all levels of intercollegiate athletics.
Roller was director of communications for the Orange Bowl Committee in Miami, Fla., from 1988 to 1991. He was with the Orange Bowl when Federal Express became its first title sponsor in 1989.
The Pearisburg, Va., native began his career in sports information. He earned his degree from Virginia Tech in 1983 and worked as a student assistant in the sports information office for four years. He was the sports information director at UNC Wilmington and East Carolina University from 1983 to 1988. While at UNC Wilmington, Roller was also executive director of the university's athletics fund-raising program.
Roller, 55, who holds a master's degree in education administration from Samford, is married to the former Carolyn Keller. He has one son, Brad, and three stepchildren – Kerstin, Kyle and Karrah.
(August 2016)


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How to get from Bounds Green to South Harrow station by tube, with a time estimate of how long it takes on the London Underground
Do you have to change trains? No
How many stops are there? 28
Tube route: Bounds Green → Wood Green → Turnpike Lane → Manor House → Finsbury Park → Arsenal → Holloway Road → Caledonian Road → Kings Cross St. Pancras → Russell Square → Holborn → Covent Garden → Leicester Square → Piccadilly Circus → Green Park → Hyde Park Corner → Knightsbridge → South Kensington → Gloucester Road → Barons Court → Hammersmith → Acton Town → Ealing Common → North Ealing → Park Royal → Alperton → Sudbury Town → Sudbury Hill → South Harrow
How long does it take? The journey time between these two London underground stations is approximately 65 minutes
Which fare zones? This tube journey is zones 1-5. You can pay by oyster, visitor oyster, zone 1-5 travelcard or contactless card. Look up the zones 1-5 fare for adults and zones 1-5 price for children
Are the trains running? Your tube line may be affected by tube engineering works. You should also check whether the tube train between Bounds Green and South Harrow is affected by a strike on the London Underground
Return journey: South Harrow to Bounds Green station
Note: Closures, cancellations and delays on the Bounds Green to South Harrow tube route may affect your journey, and you should allow for some extra travel time on top
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How much is the tube fare? The ticket price for Bounds Green to South Harrow can be found under zones 1-5 (adult) and zones 1-5 (child)
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Alternative train journey to South Harrow:
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Clinical Bioinformatics: challenges and opportunities
Research from the Eleventh International Workshop on Network Tools and Applications in Biology (NETTAB 2011)
NETTAB 2011 Workshop on Clinical Bioinformatics
Network Tools and Applications in Biology (NETTAB) Workshops are a series of meetings focused on the most promising and innovative ICT tools and to their usefulness in Bioinformatics. The NETTAB 2011 workshop, held in Pavia, Italy, in October 2011 was aimed at presenting some of the most relevant methods, tools and infrastructures that are nowadays available for Clinical Bioinformatics (CBI), the research field that deals with clinical applications of bioinformatics.
In this editorial, the viewpoints and opinions of three world CBI leaders, who have been invited to participate in a panel discussion of the NETTAB workshop on the next challenges and future opportunities of this field, are reported. These include the development of data warehouses and ICT infrastructures for data sharing, the definition of standards for sharing phenotypic data and the implementation of novel tools to implement efficient search computing solutions.
Some of the most important design features of a CBI-ICT infrastructure are presented, including data warehousing, modularity and flexibility, open-source development, semantic interoperability, integrated search and retrieval of -omics information.
Clinical Bioinformatics goals are ambitious. Many factors, including the availability of high-throughput "-omics" technologies and equipment, the widespread availability of clinical data warehouses and the noteworthy increase in data storage and computational power of the most recent ICT systems, justify research and efforts in this domain, which promises to be a crucial leveraging factor for biomedical research.
Clinical Bioinformatics (CBI) can be defined as "the clinical application of bioinformatics-associated sciences and technologies to understand molecular mechanisms and potential therapies for human diseases"
More specifically, CBI is aimed at providing methods and tools to support two different decision-makers. On the one hand, it should assist clinicians in dealing with clinical genomics (biomarker discovery), genomic medicine (identification of genotype/phenotype correlations), pharmacogenomics and genetic epidemiology at the point of care (see
Even if the main aim of CBI is very ambitious, there is a variety of enabling factors that strongly support research in this direction. First of all, in the last few years new genome sequencing and other high-throughput experimental techniques have generated vast amounts of molecular data, which, when coupled with clinical data, may lead to major biomedical discoveries, if properly exploited by researchers.
Second, new diagnostic and prognostic tests based on molecular biomarkers are increasingly available to clinicians, thus consistently refining the capability of dissecting diseases and, at the same time, enlarging the decision space on the basis of the improved assessment of risk.
Third, the increasing online availability of the "bibliome", i.e., the biomedical text corpus, made through published manuscripts, abstracts, textual comments and reports, as well as direct-to-Web publications, has stimulated the development of new algorithms able to semi-automatically extract knowledge from these texts so as to make it available in computable formats. Such algorithms have been proved to be able to effectively combine the information reported in the text with that contained in biological knowledge repositories and are increasingly used for hypothesis generation, or corroboration of clinical findings. Their use in the clinics poses challenges, but may be a consistent and important tool to support decision-making.
Finally, the consistent growth of publicly available data and knowledge sources and the possibility to easily access low-cost, high-throughput molecular technologies has meant that computational technologies and bioinformatics are increasingly central in genomic medicine; cloud computing technology is being recognised as a key technology for the future of genomic research to facilitate large-scale translational research.
Network Tools and Applications in Biology (NETTAB) Workshops are a series of meetings focused on the most promising and innovative ICT tools and to their usefulness in Bioinformatics
In this paper, the viewpoints and opinions of three world CBI leaders, who have been invited to participate in a panel discussion of the NETTAB workshop on the next challenges and future opportunities of this field, are reported.
Looking at CBI from the technological side, these experts have identified three areas that need advancement and further research. These include the development of data warehouses and ICT infrastructures for data sharing, the definition of standards for sharing phenotypic data and the implementation of novel tools to implement efficient search computing solutions. In the following of the editorial we report such opinions and discuss their relevance to the field.
ICT infrastructures for supporting clinical bioinformatics: important design features of the i2b2 system
i2b2 (Informatics for Integrating Biology and the Bedside) is an NIH-funded National Center for Biomedical Computing based at Partners HealthCare System that is an integrated framework for using clinical data for research
The back end of i2b2 has a modular software design, called the 'Hive,' that manages everything having to do with how data is stored and accessed. The front end of i2b2 is the i2b2 Web client, a user interface that allows researchers to query and analyze the underlying data. The software is open source and can be extended by users once the core cells of the Hive are included and correctly configured.
To date, i2b2 has been deployed at over 70 sites around the world, where it is being used for cohort identification, hypothesis generation and retrospective data analysis. At many of these sites, additional functionality is being developed to suit the needs of the researchers.
Several aspects of i2b2 contribute to its rapid adoption by the clinical research community. The first is that it is open source and therefore not only is it free to try, but there is a built-in set of collaborators - other users - with whom to engage both to get help with any questions and to foster innovation. The open source, self-service nature of i2b2 allows investigators to try out ideas stepwise at their own pace and at no financial cost. The online documentation and community wiki are kept up-to-date and greatly assist in user support. Secondly, both the fact that it is open source and the modularity of the design enforce backward compatibility with existing research, so that it is added to the i2b2 platform and does not become obsolete.
But perhaps the key to the utility of i2b2 is the simplicity of its database design. A research data warehouse typically includes data from disparate sources, such as electronic health records, administrative systems, genetic and research data, and lab results, to name a few. The structure of the i2b2 database allows this data to be aggregated and optimized for rapid cross-patient searching in a way that is transparent to the user. The specific design and flexibility of the data model supports new research data being added to the database as it is amassed, while allowing users to construct complex queries against the multiple source systems.
i2b2 data is stored in a star schema, first described by Kimball
Figure 1
The i2b2 star schema
The i2b2 star schema.
The star schema is optimized for analytic querying and reporting. Its design tends to mirror the way users think about and use data, which is important since users must understand what data is available in order to formulate queries. The straightforward connections between the fact and dimension tables mean that navigation through the database via joins and drilling into or rolling up dimensional data is simple and quick. The design allows the fact table to grow to billions of rows while maintaining performance. Another advantage of the fact table design is that it is well suited to handle "sparse" data; data that has many possible attributes (such as all possible medical concepts), but with only a few that are applicable. In this model, only positive facts are recorded, thus resulting in more efficient storage.
Perhaps the most powerful aspect of the i2b2 database design is the design of the metadata. In i2b2, metadata is the vocabulary, all the medical terms that describe the facts in the database. Metadata is what allows users to interact with the database. A typical clinical data warehouse may have 100,000 to 500,000 concepts, including ICD-9
Figure 2
The i2b2 Web Client is shown
The i2b2 Web Client is shown. The characteristic terms (and their respective modifiers) that describe the patients in the Clinical Research Chart are shown in the tree structure on the left. The query is composed in the upper right with the logic of a "Venn-Diagram". Terms in two different Groups will be logically ANDED together, and number of patients will be shown after computation, in this case the number of patients who are both male and have had appendicitis.
Maintaining and updating the metadata is a significant, but workable challenge. New medical codes are constantly being created, and old codes are discarded or changed. The structure of the metadata must be able to seamlessly absorb new codes while remaining backward compatible with old coding schemes. The hierarchical classification scheme of i2b2 makes it easy to map new codes to existing folders and to create new folders as needed. Entire new coding systems can be added just by creating a new folder. Discarded codes can remain in the hierarchy next to newer ones and used to reference older data, or hidden to discourage their usage in new queries.
One goal of i2b2 is to help integrate data from the many different sources that exist in modern day healthcare institutions in order to present a comprehensive view of patient care for research. The simple and intuitive design of the i2b2 database enables users to construct complex queries over these disparate data sources.
Using the new generation of Healthcare and Life Sciences standards for Personalized Medicine
The success of Personalized Medicine (PM) at the point of care is dependent on the effective use of PM knowledge (e.g., pharmacogenomic interpretation of somatic mutations in tumor tissues) while considering the complete patient's medical history (e.g., other diseases, medications, allergies, and genetic mutations).
In order for PM knowledge to be effectively applied to the patient medical records, representations of data and knowledge need to be standardized due to the heterogeneity of their original formats. Both data and knowledge are generated nowadays by a variety of sources, each of them using proprietary formats and idiosyncratic semantics, often not represented explicitly (for example, when contextual data is unstructured and thus cannot be parsed by decision support applications).
Interpretation of clinical data typically starts at parsing the metadata, e.g., the predefined schemas of clinical information systems. However, these schemas (most often relational) cannot accommodate the complexity of contextual data representation. Thus, it is important to have a richer language allowing the explicit representation of patient-specific context of each discrete data item and of how it relates to other data items, as well as how it fits within the entire health history of an individual.
Dispersed and disparate medical records of a patient are often inconsistent and incoherent. A patient-centric, longitudinal electronic health record (EHR) based on international standards (e.g., CEN EHR 13606
The representation of such raw data should adhere, as much as possible, to common and agreed-upon reference models (e.g., HL7/ISO RIM - Reference Information Model
The abovementioned reference models can underlie the logical models of health data warehousing. Such warehousing could maintain the richest semantic representation of data and knowledge in a way that is also interoperable with other information systems. Performing specific tasks, such as summarizing patient data or analyzing cohort data in research studies, needs more optimized representations of the data and knowledge persisted in warehouses. Data marts are such optimized representations, and multiple data marts could be derived from a single warehouse. For example, the star schema underlying the i2b2 framework (see Figure
In many cross-enterprise warehousing efforts, the main format used to convey patient data is the Clinical Document Architecture (CDA) standard
The efforts to apply Natural Language Processing (NLP) to health information could be connected to healthcare information technologies through standards like CDA that uses the clinical statement concept. The NLP fundamentals can be reduced to the clinical statement constituents and the CDA can thus be a good "catcher" of the results of NLP running over unstructured health information.
Search and extraction of relevant information from big data amounts
The continuously increasing amount of available data poses significant technological and computational challenges, both to their management (collection, storage, integration, preservation) and effective use (access, sharing, search, extraction, analysis). This issue is becoming predominant in several fields and it is being addressed in different ways, according to each specific field peculiarities.
The Web is a paradigmatic field for this aspect. A rapidly growing mass of data is flooding the Web. Yet, leveraging on the typical linked nature of Web data, technological and computational advancements are preventing (at least for now) drowning by Web data. Automatic robots have been implemented to crawl the Web resources, collect their huge key data and store them in powerful database management systems. Effective indexing and ranking techniques, such as the Google PageRank
Such ability, which is tremendously boosting the Web as an extraordinary easy-to-use source of information, is based on the assumption that user searches are mainly aimed at finding "
Especially in the CBI field, the amount of collected data is continuously and rapidly increasing, in particular with the recent collection of -omics data. Also, compared to the Web, the current ability of extracting relevant biomedical information and of answering even common CBI questions is far less, due to many reasons.
First, the biomedical-molecular data - which are of various types - are stored in several different formats within systems that are distributed, heterogeneous, and often not interoperable. Furthermore, a lot of important information is subjectively described in free texts, within chief complaints, discharge letters, clinical reports or referrals, which are intrinsically unstructured. The adoption of electronic medical or health records can significantly enhance the availability and sharing of clinical data and information, which are still only on paper in very many healthcare sites. Yet, the digitalization of health data alone is far from sufficient; having clinical reports and referrals in PDF format is evidently not enough to solve the information extraction and question answering issues. A standard data and information representation according to a shared reference model has to be adopted, together with controlled terminologies and ontologies to objectively describe medical and biomolecular findings. Moreover, the use of advanced Natural Language Processing techniques suited for the clinical domain to extract and structure information from previous medical textual descriptions can also greatly help.
Second, usual biomedical-molecular questions are generally more complex than Web search questions. They often involve more types of data, as well as topics with usually several attributes. In many cases, retrieving only a few of the items related to a biomedical-molecular search question, or even the K top items according to some user-defined ranking, may not be enough for a proper answer, which can instead require the exploration of all available items and their attributes.
Advanced search computing techniques are being developed to answer complex, multi-topic Web search questions involving the integration of possibly ranked partial search results
CBI goals are ambitious, but many factors, from the availability of high-throughput "-omics" technologies and equipment, allowing identifying "individual" genomes and proteomes, to the incredible increase in data storage and computational power that is allowed by most recent ICT systems, justify research and efforts in this domain.
In this paper, we have reported some points of view on the current and future challenges in this domain that were discussed in a panel session at the NETTAB 2012 workshop on Clinical Bioinformatics.
First, we presented what we believe are the most important design features of a CBI-ICT infrastructure, by taking into account some achievements of the i2b2 system. Data warehousing is essential in CBI because of the great amount of clinical and biomedical information that needs to be generated and managed within health organizations. Indeed, CBI depends on information that is gathered from single individuals, usually patients, and thus it cannot exclusively depend on general population or species oriented databases that are available on-line from main data providers. On the contrary, these general resources may only be used as a general reference, while the most important data is provided by individual's clinical and molecular information.
Some of the most relevant features of a data warehouse for CBI have been identified by examining the i2b2 experience. Simplicity of the database schema is a key factor, facilitating the modularity and flexibility of the system, that support its continuous development and improvement, and making optimization of queries and searches possible. Modularity is indeed essential also because of the various and heterogeneous data and sources that may be usefully included in the data warehouse, thus leading to a multiplicity of goals and application domains for the system.
The open source approach is also extremely important, since it is able to fully exploit collaboration among users both for software development and for new features design. Collaborative development is especially important for the maintenance and update of shared metadata that, being used by the users as the main means to interact with the database, determine in fact its real usefulness and success.
Of course, individuals are moving, and information is being accumulated in many health organizations and information systems, that need to interoperate so that all possible information on each patient is made swiftly available when it is needed. This is a precondition for the clinicians in order to be able to deal at the point of care with all needed information for a proper, molecular-enabled, diagnosis, prognosis and optimized treatment selection.
Moreover, CBI data analysis may be greatly facilitated and improved when the population under analysis is the greatest possible. Such clinical-related processes as biomarker discovery and identification of genotype/phenotype correlations may only be carried out when a sufficient amount of data is available. So, interoperation of information systems should support both integration of data on single individuals and coming from many patients. Hence, it is of extreme relevance.
In this paper, we have therefore also faced the interoperability issue, and we have discussed about some of the most recent standards for data modelling and data interchange and their possible use in CBI to overcome heterogeneity of original data and knowledge formats, as well as modelling of arising information. In this case, international standards exist and should be adopted, with the provision that new evidence arising as a result of genomic medicine efforts be also properly included. We also highlighted that the application of a shared reference model could lead to a standard, semantics rich, processable representation of clinical statements.
CBI is not limited, however, to the analysis of the information on a given individual by the health care personnel that provide him/her assistance. As previously said, it must also support researchers in the reuse of clinical data for research purposes. Many new applications are being developed by researchers in the field, who can largely benefit from making access and searching information resources through Web services. It is often from such free access to data that new associations may be identified, possibly leading to hypothesis for new biomarkers validation and assessment.
In this paper, we have therefore also tried to point out which currently are the main difficulties in making access and searching CBI related information sources.
First, we addressed the idea that the adoption of common data models could be the best starting point for the implementation of a set of data marts, optimized representations of data included in warehouses for performing specific research tasks. New data marts, each devoted to a different task, could easily be created and made available.
Current techniques and technologies aimed at searching data on the Web, even the most advanced, do not seem completely adequate for CBI needs, where queries are complex, involving many data sources simultaneously and, often, requesting from each resource more results than the first that are usually returned. One of the most demanding issues remains access to a lot of information that is included, and subjectively described, in free texts, which are intrinsically unstructured. The use of controlled terminologies and of ontologies, whenever possible, together with the adoption of NLP tools suited for the clinical and biological domains can indeed support extraction of information from medical textual descriptions.
We finally moved to the issue of searching and extracting information from big data amounts. Queries which are relevant in CBI often require retrieving result sets bigger than usual and the exploration of all available items and their attributes because of possible correlations among data in the results that could change, even sensibly, their relevance to the overall query. Of particular interest are those advanced search computing techniques, which are aimed at integrating ranked search results from multiple sources.
The integrated search and retrieval of CBI data from multiple sources and its comprehensive analysis constitute in our opinion one of the biggest challenges for the future. The NETTAB 2013 workshop will be devoted to this theme.
List of abbreviations used
CBI: Clinical Bioinformatics; CDA: Clinical Document Architecture; CEN: Comité Européen de Normalisation (European Committee for Standardization); CPT: Current Procedural Terminology; EHR: Electronic Health Record; HCPCS: Healthcare Common Procedure Coding System; HL7: Health Level 7; i2b2: Informatics for Integrating Biology and the Bedside; ICD-9: International Classification of Diseases rel. 9; ISO: International Standard Organization; LOINC: Logical Observation Identifiers Names and Codes; NDC: National Drug Code; NETTAB: Network Tools and Applications in Biology; NIH: National Institute of Health; NLP: Natural Language Processing; RIM: Reference Information Model; RM: Reference Model; SNOMED: Systematized Nomenclature of Medicine; TBI: Translational Bioinformatics.
Competing interests
The authors declare that they have no competing interests.
Authors' contributions
RB and PR conceived the work, wrote the background and introduction and drafted the conclusions. MM, SM, and AS contributed by identifying and specifying issues in one of the three main chapters, respectively on data search and extraction, data warehouse platform, and standardization and interoperability. All authors revised, discussed, and amended the manuscript and approved its final version.
This work was supported in part by the project Onco-i2b2, funded by "Regione Lombardia", and by the FIRB project ITALBIONET, funded by the Italian Ministry of Research.
This article has been published as part of
Clinical bioinformatics: a new emerging science
Translational bioinformatics: coming of age
Translational bioinformatics: linking knowledge across biological and clinical realms
Serving the enterprise and beyond with informatics for integrating biology and the bedside (i2b2)
NETTAB Workshops
The Data Warehouse Toolkit: practical techniques for building dimensional data warehouses
CPT - Current procedural terminology
HCPCS - Healthcare common procedure coding system
NDC - National Drug Code
LOINC - Logical Observation Identifiers Names and Codes
European Committee for Standardization (CEN) - Semantic interoperability in the electronic health record communication
HL7 (Health Level Seven) Version 3 Standard: Foundation (Reference Information Model, Data Types and Vocabulary)
HL7 Clinical Document Architecture, Release 2
Google's PageRank and beyond: the science of search engine rankings
Bio-Search Computing: integration and global ranking of bioinformatics search results


text: I have a question. So if I buy a XenForo license, do I need an external host in order to run this, or can I just pay the $140 and have the forums at hand and ready to go for the year without an external hosting service? Just wondering since I have seen many forums with XenForo and am considering attempting to get it.


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Here's something that'll make you feel like you're living in the future.
A company named Recreus makes a flexible filament called FilaFlex for 3D printers that actually lets you 3D print your own custom sneakers.
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School Overview
|School Type
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- Welcome to the Blue Ash KinderCare located on Cornell Road servicing families who work and live in the Blue Ash, Sharonville, West Chester, and Reading areas. We are so excited to meet with you and your family. Our experts designed our classrooms to help prepare your child for success in school and beyond. With designated learning centers in every classroom, children have the opportunity for rich social play and child initiated discovery. We believe in developing the whole child with an emphasis on assisting your child's growth with their social, emotional, cognitive, and physical development. In our community we know it takes a village to raise a child so our professionals communicate daily with parents on their child's development, and their expectations of our program. Your child will not only have a safe, secure, and stimulating environment to learn in, but will have support from a team of professionals who have a true passion for educating and nurturing children.
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The nearest high school is Ursuline Academy (1.7 miles away)
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CincinnatiGrades: NS-1 | 110 students
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10969 Reed Hartman Hwy
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Blue AshGrades: PK-KG | 261 students
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School Reviews
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July 25, 2017
A table comparison of the three popular early childhood education approaches.
July 25, 2017
How do I know how this school compares with the others I am considering? Has anybody ranked private schools?
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text:
We're using SOAE as a proxy to call external web services. The connection between SOAE and the external part is encrypted using SSL. And that part seem to be working fine. We get succesfull test when testing the invocation agent through the admin console.
We are having some problems decoding the error messages SOAE throw at us. We can see the request we're sending in, in the logs. But, nothing later (except for a lot of debug messages).
Is it possible to see what (if anything) SOAE sends to the backend server? Is it possible to see the response (if anything) from the backend server?
With different configurations, this is one error message we've seen:
Exception occurred during processing of invocation response: Couldn't report the fault through the inbound partnerLink: Uncaught BPEL fault http://www.intel.com/soae/bpel/bpel20-2007a/:replyFailure (Failed to post message to input server. Exception: WProcessorCallbacksImpl: Failed to prepare outbound buffers HTTP style headers can only be added to the metadata elements and . Neither of these elements is present in the metadata, so the requested headers can't be merged into the metadata. The metadata can't be updated. to process reply for
s:sequence[1]/bpws:reply[1], name=Reply] Either a reply activity has already been executed, or there is no reply activity in the workflow for this inbound partnerLink.
Back end failure
As the connection is encrypted, and we don't have direct access to the backend server, it is hard to debug. We would therefore really appreciate if anyone knows if it's possible to see what SOAE sends to the server, and hopefully also what the server replys with.
Btw, the workflow does test successfully when testing with dummy requests and responses in the designer...
With some changes in the workflow, I get this error-message in stead:
<?xml version="1.0" encoding="utf-8"?>
X:invocationAgentFailureUncaught BPEL fault http://www.intel.com/soae/bpel/bpel20-2007a/:invocationAgentFailure (Invocation agent failed: (Status = MSG_SERVICE_FAILURE)) executing instruction #12: INVOKE_RESPONSE [ ima = Invoke_IMA_Key (id=3), onlyKey=false, throwOnFault=true, partsCount: 1][file=../app/ExternalPartner.bpel, line=122, path=/bpws:process[1]/bpws:sequence[1]/bpws:extensionActivity[2]/soae-ab:InvokeBuilder[1]/bpws:scope[1]/bpws:sequence[1]/bpws:invoke[1], name=Invoke]
Best Regards,


text:
PYSSH (Secure Shell) is a implementation of SSH1 protocol in Python. It provides strong authentication and secure communications over insecure networks.
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