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1 MARK J. HOROSCHAK Womble Carlyle Sandridge & Rice, PLLC 3500 One Wachovia Center 301 South College Street Charlotte, North Carolina Telephone: (704) Facsimile: (704) PROFESSIONAL EXPERIENCE Member Womble Carlyle Sandridge & Rice, PLLC Charlotte, North Carolina November Present A nationally recognized antitrust expert, Mr. Horoschak has established a broad-based practice, representing health care systems and other businesses in transactional counseling, governmental investigations, and litigation. Recent engagements include: Acquisition of NorthEast Medical Center in Concord, NC by Carolinas HealthCare System (July 2007). Acquisition of majority interest in Inmar, Inc., by New Mountain Capital, LLC (April 2007). Affiliation of Summa Health System in Akron, Ohio, and Robinson Memorial Hospital in Ravena, Ohio (January 2007). Affiliation of St. Cloud Regional Medical Center in St. Cloud, Florida, and Orlando Regional HealthCare System (November 2006). Acquisition of Tennessee Christian Medical Center in Madison, Tennessee, by HCA Inc. (February 2006). Affiliation of Triad Hospitals, Inc. and Seton Health System to establish a hospital in Cedar Park, Texas (February 2006). Cohlmia v. Ardent Health Services, LLC et al., Case No. 05-CV JHP-PJC (N.D. Oklahoma complaint filed July 7, 2005) (pending).
2 Page 2 Affiliation of Summit Hospital and Ochsner Clinic Foundation in Baton Rouge, Louisiana (January 2005). Acquisition of assets of Cimarron Health Plan by Lovelace Sandia Health System (June 2004). Sale of Alice Regional Hospital in Alice, Texas, to Christus Spohn Health System (June 2004). Partnership of Triad Hospitals, Inc., and Texas Health Resources to establish Presbyterian Hospital of Denton in Denton, Texas (May 2004). Biddulph et al. v. HCA Inc., et al., Case No. CV (Seventh Judicial District Court of Bonneville County, Idaho, complaint filed March 3, 2004) - Dismissal as per settlement. Rocky Mountain Medical Center, Inc. v. Northern Utah Healthcare Corporation, d/b/a St. Mark s Hospital, Civil Action No (Third Judicial District Court of Salt Lake County, Utah, order granting summary judgment filed January 27, 2004) - Successful defense of client hospital s managed care contracting practices. Acquisition of St. Joseph Health System and Lovelace Health Systems in Albuquerque, New Mexico, by Ardent Health Services, LLC (January 2003). Sale of Middle Georgia Hospital in Macon, Georgia, to Medical Center of Central Georgia (October 2002). Sale of CCN Managed Care, Inc., to First Health Corporation (August 2001). Acquisition of Healthsouth Medical Center in Richmond, Virginia, by HCA Inc. (March 2001). Sale of Installation Products Division of Armstrong World Industries to Ardex America, L.P. (July 2000). Sale of Winter Park Memorial Hospital in Winter Park, Florida, to Adventist Health System (April 2000). Sale of Atlantic Medical Center facilities in Daytona Beach and Ormond Beach, Florida, to Halifax Medical Center and Memorial Health System (November 1999). Affiliation of Grace Memorial Hospital and Valdese General Hospital in Burke County, North Carolina, to establish Blue Ridge Healthcare System (August 1999).
3 Page 3 Transfer of Leasehold Interest and Assets of Highsmith-Rainey Memorial Hospital in Fayetteville, North Carolina, to Cumberland County Hospital System (April 1999). Acquisition of Alexian Brothers Hospital in San Jose, California, by Columbia/HCA Healthcare Corporation (December 1998). Affiliation of Vicksburg Medical Center and Parkview Hospital in Vicksburg, Mississippi (August 1998). Affiliation of Roper Hospital, Roper Hospital North, St. Francis Hospital in Charleston, South Carolina, and Carolinas HealthCare System to establish Roper CareAlliance, LLC (July 1998). Acquisition of Heritage Hospital in Tarboro, North Carolina, by Pitt County Memorial Hospital (June 1998). Merger of Sentara Health System and Tidewater Healthcare, Inc. in southeastern Virginia (June 1998). Affiliation of Coliseum Medical Centers, Coliseum Psychiatric Center, Macon Northside Hospital and Middle Georgia Hospital to establish Macon Healthcare, LLC in Macon, Georgia (April 1998). In re Mesa County Physicians IPA, Inc., FTC Dkt. No (February 1998) - FTC litigation against client physician organization settled on favorable terms. Aluko et al. v. Charlotte Mecklenburg Hospital Authority et al., 959 F. Supp. 729 (W.D.N.C. 1997) - Dismissal of complaint challenging exclusive contracting and medical staff policies of client hospital system. Merger of Tenet Healthcare Corporation and OrNda Healthcare Corporation (January 1997). Assistant Director September October 1995 Bureau of Competition Federal Trade Commission Mr. Horoschak was responsible for developing and implementing the FTC s antitrust enforcement program governing the health care industry during a period of unprecedented change in that industry. Major accomplishments included:
4 Page 4 Successful litigation of FTC v. University Health, Inc., 938 F.2d 1206 (11th Cir. 1991), and FTC v. Columbia Hospital Corp., No FTM-CIV-23D (M.D. Fla., preliminary injunction issued May 21, 1993), in which proposed hospital mergers were enjoined. Development and expansion of the Statements of Enforcement Policy and Analytical Principles Relating to Health Care and Antitrust which were jointly issued by the U.S. Department of Justice and Federal Trade Commission. Issuance of 24 advisory opinions on provider joint ventures and networks, business coalition activities, and professional self-regulation. Prior to taking charge of the health care program, Mr. Horoschak held a variety of positions with the FTC between 1984 and 1989, including Assistant General Counsel for the Commission and Acting Executive Assistant (Chief of Staff) and Attorney-Advisor for the Chairman of the Commission. Associate February October 1984 Hunton & Williams Richmond, Virginia Mr. Horoschak participated in a broad range of antitrust litigation and counseling matters, as well as in administrative litigation before the Nuclear Regulatory Commission and before state procurement agencies. Attorney June January 1980 General Motors Corporation Detroit, Michigan At the time of departure, Mr. Horoschak had supervisory responsibility for reviewing all corporate advertising, and had actively participated in all phases of the successful litigation of In re General Motors Corporation, 99 F.T.C. 464 (1982), resulting in the dismissal of a complaint that General Motors had unreasonably restrained competition in the sale and distribution of automotive body crash parts in violation of the Federal Trade Commission Act.
5 Page 5 BAR MEMBERSHIPS American Bar Association Editor, Antitrust Law Developments Supplement ( ) Vice Chair, Health Care Committee, Antitrust Section ( ; ) Program Director, Health Care Committee, Antitrust Section ( ) North Carolina Bar Association Chair, Antitrust and Trade Regulation Section ( ) North Carolina State Bar South Carolina Bar PROFESSIONAL HONORS Best Lawyers in America ( ) Chambers USA: America's Leading Lawyers for Business ( ) - Awarded highest rank in both Antitrust and Litigation: Healthcare categories. Legal Elite of North Carolina ( ) North Carolina Super Lawyers ( ) Member, Legal and Regulatory Council of Advisors, Gerson Lehrman Group PUBLICATIONS Economic Credentialing and Exclusionary Conduct Under the Sherman Act, 19 ABA ANTITRUST HEALTH CARE CHRON. 3 (October 2005) Annual Review of Antitrust Law Developments, ABA Antitrust Section (Editorial Vice- Chair). You ve Got [Investigative] Mail: Respond to a Government Inquiry, NC BAR ASSOCIATION ANTITRUST NEWS, vol. 13, no. 1 (Winter 2003) (Co-Author). Antitrust and Rural Health Care Networks, 13 ABA ANTITRUST HEALTH CARE CHRON. 2 (1999). Antitrust Guidance for Health Care Providers Enters a New Phase, ANTITRUST (Fall 1996) at 28. New Market for Hospital Mergers, LEGAL TIMES, March 4, 1996, at S25. Antitrust Developments in Evolving Health Care Markets, ABA Section of Antitrust Law (1996) (contributing author).
6 Page 6 Antitrust Perspectives on Joint Ventures Among Health Care Providers, 6 ANTITRUST HEALTH CARE CHRON. 2 (1992). Medical Staff Privileges and the Antitrust Laws: A View from the Federal Trade Commission, 6 MEDICAL STAFF COUNSELOR 17 (1992). Advertising Regulation and the Antitrust Laws, 77 FED. BULL. 238 (1990). An Update on the FTC Health Care Antitrust Program, 4 ANTITRUST HEALTH CARE CHRON. 2 (1990). EDUCATION College of William & Mary Juris Doctor, 1976 Academic Honors: Articles Editor, William & Mary Law Review Tazewell Taylor Scholarship W.A.R. Goodwin Memorial Scholarship American University Bachelor of Arts in Political Science, Cum Laude, 1973 Academic Honors: Phi Kappa Phi Pi Sigma Alpha WCSR v3
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text:
BD 1047 dihydrobromide
Cat. No. 0956
Price and AvailabilityBy clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.
Chemical Name: N-[2-(3,4-Dichlorophenyl)ethyl]-N-m
Biological Activityσ1 receptor antagonist, exhibiting a similar binding profile to that of BD 1063 (Cat. No. 0883) but with higher affinity (approximately 10-fold) at both σ1 and σ2 sites.
Technical DataM.Wt:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Garrone et al (2000) Effects of trazodone on neurotransmitter release from rat mossy fibre cerebellar synaptosomes. Eur.J.Pharmacol. 400 35. PMID: 10913582.
Romieu et al (2000) Involvement of the sigma1 receptor in the cocaine-induced conditioned place preference. Neuroreport 11 2885. PMID: 11006959.
Matsumoto et al (1995) Characterisation of two novel σ receptor ligands: antidystonic effects in rats suggest σ receptor antagonism. Eur.J.Pharmacol. 280 301. PMID: 8566098.
If you know of a relevant reference for BD 1047 dihydrobromide please let us know.
Citations are publications that use Tocris products. Selected citations for BD 1047 dihydrobromide include:
Rodríguez-Muñoz et al (2015) The ON:OFF switch, σ1R-HINT1 protein, controls GPCR-NMDA receptor cross-regulation: implications in neurological disorders. Int J Neuropsychopharmacol 6 35458. PMID: 26461475.
Gear et al (2014) NOP receptor mediates anti-analgesia induced by agonist-antagonist opioids. Neuroscience 257 139. PMID: 24188792.
Nguyen et al (2014) Involvement of sigma-1 receptors in the antidepressant-like effects of dextromethorphan. PLoS One 9 e89985. PMID: 24587167.
Pan et al (2014) σ-1 receptor antagonism restores injury-induced decrease of voltage-gated Ca2+ current in sensory neurons. Exp Ther Med 350 290. PMID: 24891452.
Sánchez-Blázquez et al (2014) The calcium-sensitive σ-1 receptor prevents cannabinoids from provoking glutamate NMDA receptor hypofunction: implications in antinociception and psychotic diseases. Korean J Physiol Pharmacol 17 1943. PMID: 24485144.
Su et al (2014) Effects of BD1047, aσ1 receptor antagonist, on the expression of mTOR, Camk2γ and GSK-3β in fluvoxamine-treated N2a cells. Oncotarget 7 435. PMID: 24396420.
Kourrich et al (2013) Dynamic interaction between sigma-1 receptor and Kv1.2 shapes neuronal and behavioral responses to cocaine. Cell 152 236. PMID: 23332758.
Hiranita et al (2011) Decreases in cocaine self-administration with dual inhibition of the dopamine transporter and σ receptors. J Pharmacol Exp Ther 339 662. PMID: 21859929.
Son and Kwon (2010) σ-1 Receptor Antagonist BD1047 Reduces Allodynia and Spinal ERK Phosphorylation Following Chronic Compression of Dorsal Root Ganglion in Rats. J Neurophysiol 14 359. PMID: 21311675.
Kwon et al (2009) The Antinociceptive Effect of σ-1 Receptor Antagonist, BD1047, in a Capsaicin Induced Headache Model in Rats. Br J Ophthalmol 13 425. PMID: 20054487.
Yoon et al (2009) Intrathecal injection of the neurosteroid, DHEAS, produces mechanical allodynia in mice: involvement of spinal sigma-1 and GABA receptors. Br J Pharmacol 157 666. PMID: 19422393.
Cantarella et al (2007) Protective effects of the σ agonist Pre-084 in the rat retina. Korean J Physiol Pharmacol 91 1382. PMID: 17522150.
Shin et al (2005) The dextromethorphan analog dimemorfan attenuates kainate-induced seizures via sigma1 receptor activation: comparison with the effects of dextromethorphan. Br J Pharmacol 144 908. PMID: 15723099.
Brown et al (2004) Antitussive activity of sigma-1 receptor agonists in the guinea-pig. Br J Pharmacol 141 233. PMID: 14691051.
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subset: commoncrawl


text:
Download the Game Design and Indie Game Marketing Freebook 07/19/17GameDev.net and CRC Press have teamed up to bring a free ebook of content curated from top titles published by CRC Press. The freebook, Practices of Game Design & Indie Game Marketing, includes chapters from The Art of Game Design: A Book of Lenses, A Practical Guide to Indie Game Marketing, and An Architectural Approach to Level Design. The GameDev.net FreeBook is relevant to game designers, developers, and those interested in learning more about the challenges in game development. We know game development can be a tough discipline and business, so we picked several chapters from CRC Press titles that we thought would be of interest to you, the GameDev.net audience, in your journey to design, develop, and market your next game. The free ebook is available through CRC Press by clicking here. The Curated Books The Art of Game Design: A Book of Lenses, Second Edition, by Jesse Schell Presents 100+ sets of questions, or different lenses, for viewing a game's design, encompassing diverse fields such as psychology, architecture, music, film, software engineering, theme park design, mathematics, anthropology, and more. Written by one of the world's top game designers, this book describes the deepest and most fundamental principles of game design, demonstrating how tactics used in board, card, and athletic games also work in video games. It provides practical instruction on creating world-class games that will be played again and again. View it here. A Practical Guide to Indie Game Marketing, by Joel Dreskin Marketing is an essential but too frequently overlooked or minimized component of the release plan for indie games. A Practical Guide to Indie Game Marketing provides you with the tools needed to build visibility and sell your indie games. With special focus on those developers with small budgets and limited staff and resources, this book is packed with tangible recommendations and techniques that you can put to use immediately. As a seasoned professional of the indie game arena, author Joel Dreskin gives you insight into practical, real-world experiences of marketing numerous successful games and also provides stories of the failures. View it here. An Architectural Approach to Level Design This is one of the first books to integrate architectural and spatial design theory with the field of level design. The book presents architectural techniques and theories for level designers to use in their own work. It connects architecture and level design in different ways that address the practical elements of how designers construct space and the experiential elements of how and why humans interact with this space. Throughout the text, readers learn skills for spatial layout, evoking emotion through gamespaces, and creating better levels through architectural theory. View it here. Learn more and download the ebook by clicking here. Did you know? GameDev.net and CRC Press also recently teamed up to bring GDNet+ Members up to a 20% discount on all CRC Press books. Learn more about this and other benefits here.
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dilyan_rusev replied to cambalinho's topic in General and Gameplay ProgrammingI don't really get your logic, but for all things Microsoft, you should look it up on MSDN. https://msdn.microsoft.com/en-us/library/windows/desktop/ms648009%28v=vs.85%29.aspx
dilyan_rusev replied to cambalinho's topic in General and Gameplay ProgrammingThe only thing that can go wrong is the HINSTANCE you pass. In the call to LoadBitmap, you use (HINSTANCE)GetWindowLong(WindowMain, GWL_HINSTANCE) By default, that would be the HINSTANCE you passed to WNDCLASS/WNDCLASSEX you registered before you created the HWND via CreateWindow/CreateWindowEx. The association is the class name. With FindResource, you obtain the HINSTANCE via GetModuleHandle(NULL) which is used to get the HINSTANCE of the exe that started the process. In the rare case that these two differ (e.g. the code is split between EXE and DLL-s), you should call LoadBitmap with GetModuleHandle(NULL).
dilyan_rusev replied to TinyTertle's topic in General and Gameplay ProgrammingI haven't tried it, but my guess would be that you'd have to re-create the window and its renderer.
dilyan_rusev replied to Maurition's topic in For BeginnersThis is the reason I like using std::vector and it's data() accessor. Priceless when you have to work with Win32.
dilyan_rusev replied to 3Ddreamer's topic in For BeginnersI do not think such a thing is possible. TLDR: Operating systems are different and they handle software installation in a different fashion. Next-next installers are a very Windows thing. Other OS-es handle adding software quite differently. Do not belive that there is a magic pill that will help you distribute your software in a uniform way (well, apart from Steam maybe). At the very least, users of different OS-es *expect* that adding software will be done differently. The details: On Windows: the classic is to use Windows Installer (a.k.a. .msi) many companies use WIX, an abstraction over WI. It is free, and also open source, if you care about that. some use InstallShield many use the Nullsoft installer (NSIS) - also free and open source you can write your own from scratch, it is relatively easy (if you have even modest Win32 experience). Time consuming if you haven't written an installer before. On Linux dstributions - there is no such a thing as universal installer :) They all go out of their way to make it difficult to provide binary packages that can survive more than a few releases/years, let alone compatible across distributions. There are alternatives to WI, such as .deb and .rpm, but I would recommend against going that route if you depend on other packages being installed, as packages get split or renamed over the years. Most software that works even after decades is to basically statically link against everything and do not depend on OS filesystem layout besides ~ and your installation directory. Also, limit your use of OS libraries to the bare minimum - prefer building all dependencies on your own and bundle them with your app (as you would on Windows). Plan to include a shell script that will force the loader to use your libraries instead of the system libraries (as they will be built with a different compiler version, etc). If you want graphical installer for Linux - there used to be the Loki installer, but I'd recommend to try Steam and link to their libraries. It will be easier for both you and your users. I've never owned a Mac, so I can't say anything about that.
dilyan_rusev replied to _Kaven_'s topic in General and Gameplay ProgrammingIt really depends on what you want to do. For game development, C# + WinForms is the easiest way to integrate with native code (if you're writing an editor or just need a lot of P/Invoke). For business applications, C# + WinForms isn't dead either. Visual Studio's WinForms designer makes it easy to very quickly write small utility applications, which is ofthen what IT departments would do, especially for state institutions. WPF can achieve impressive visuals, but suffers from internal Microsoft power struggels (the guys that do tools vs the guys that do the OS). If it is updated to more easily support newer DX withouth the Windows Runtime, I guess it will be used even more. All the flashy news are for web technologies, and Microsoft try to follow with ASP.NET MVC. Last time I wrote a site with MVC, I was impressed with how easy it was. You get ORM + template engine + great debugging experience. Recentely, they've been going to the world of "stuff happeing automagically if you follow The Convention". Whether or not you like that is a matter of preference. In my opinion, their web stack is a good piece of technology, and it has its following. ASP.NET WebForms is dated technology. People hate on it too much, IMO. Still, a few years ago it was VERY popular, and lots and lots of sites were written using it. Which means they'll have to be supported. Also, some .NET CMS-es were based on WebForms. I guess they've isolated those parts over the years, but that means even more sites depend on WebForms. Again, my own opinion is that this is not a very good implementation, but the idea of reusable components is a good one. When it comes to databases... I haven't done that in years. What most people around me use these days are either ORMs that are related to the framework/language of their choice, or a very small population of very vocal hipsters that use alternative storages, like MongoDB. IMHO most sites can do with SQLite, but many people want to engineer big and complicated setups for sites with less than a thousand visitors a month. My advice would be: get familiar with basic SQL syntax. You don't need to be a wizard or anything, but if you use an ORM, you will have to go down to SQL when debugging. Also, regardless of what database engine you use, the basic SQL is mostly the same. When you are at it, take some time to look at MongoDB - it is the most popular alternative storage in my dev circle. In summary: .NET ain't dead yet. If you work with .NET, you'll be most likely doing business apps/sites or supporting such. This is not bad, as it is usually a very stress-free job that pays well. If you want to do web, forget two years of studying. Start writing simple sites ASAP and learn on the go. Blog would do - the ability to write blog posts & comments in a site is a nice test to see if you can handle security (logging in, setting up https), storage (can go with simple files, any SQL engine, or the new document storages), templates and client-side programming. When you do a veeeery simple blog post, do one-pager site (e.g. https://onepagelove.com/) and make it mobile-friendly with responsive design. If you pull these off, you're ready for 99% of web development jobs. Plus, you've immediately hireable, as you have something to show for your words.
dilyan_rusev replied to Flyverse's topic in General and Gameplay ProgrammingIIRC, an variable of an empty struct would also be at least one bit, beacuse the stardard says every variable must be addressable (via the & operator). I do not remember if it is one bit or whatever the compiler decides, though. x86 can and does process 8 bits via the original A, B and C registers, this is used for casting between ints of different size, IIRC. Also, nothing stops you from using bitwize operations to store and extract bits from an unsigned integral type. As others have said, vector<bool> is supposed to do that for you; the implementation depends on unique values being a power of 2; you store with bitwize | (result is assigned to storage) and extract with bitwize & (result is tested flag if present).
dilyan_rusev replied to blueshogun96's topic in General and Gameplay ProgrammingI watched this a while ago and find it useful: https://www.youtube.com/watch?v=Sd8ie5R4CVE It explains what Valve recommends. Mostly, SDL2 libraries handle most of the OS/DirectX stuff, and OpenGL replaces Direct3D. Also, one advise I've found on my own: if your game is not too complex, you can do almost all the work on Windows. Booting to a Linux distro just to make sure it compiles and runs properly has been my strategy so far for small personal projects.
dilyan_rusev replied to Aenn's topic in General and Gameplay ProgrammingIf you are comfortable with developing only for Windows, the combination of Direct2D, WIC and DirectWrite is very powerful. It is COM-based, so things like Microsoft::WRL::ComPtr will come in handy. The DirectXTK that @NightCreature83 linked to tries to emulate XNA in C++ with Direct3D11. The big difference between Direct2D & friends and SDL/SFML/DirectXTK is the ability to easily draw complicated high-quality geometrical shapes the ability to (relatively) easily draw high-quality text with advanced Photoshop-like effects (shadow, outlines, gradients, etc) If you don't need these things (like most 2D games), then SDL/SFML and DirectXTK will all work quite well. It is also worth noting that both SFML and SDL offer much simpler APIs than the DirectX (Direct2D, WIC, DirectWrite, Direct3D11 + DirectXTK). Regardless of which API you choose, if you program on Windows with Visual Studio, OutputDebugString is your friend :) For beginners, I think 3D is an overkill. It is much easer to find 2D assets and 2D artists, also the programming part is much easier; you need almost no math.
dilyan_rusev replied to Magogan's topic in General and Gameplay ProgrammingYou can do that, or you can write your own. It's all resources, registry settings, temp files, running other installers and public Windows API. If you want to do the installer quickly, use Inno or NSIS. In case you are curious how it works on the inside, or you want to heavily customize the UI, you might have to roll your own.
dilyan_rusev replied to Funkymunky's topic in General and Gameplay ProgrammingI don't know about the rest of the code, but the DlgProc in what you posted above seems wrong. http://msdn.microsoft.com/en-us/library/windows/desktop/ms645469(v=vs.85).aspx You seem to always return FALSE, which doesn't look good to me.
dilyan_rusev replied to _Kaven_'s topic in General and Gameplay ProgrammingI haven't got the time yet to take a look at what's been open-sourced, but the advantage of Mono over .NET is, and has always been, that it can be embedded in your app. No messy installations, just copy-paste a lot of files into your game directory. A lot of people underestimate installers/uninstallers :) I'm curious what will follow. Making VS free for "non-enterprise users" (in the Connect() videos they said small companies and indie devs are OK) is an awesome move. If they invest in clang for windows apps (mainly for the clang tools), it would be really awesome.
dilyan_rusev replied to Ovicior's topic in General and Gameplay ProgrammingTL;DR; - No Java in Visual Studo; whether Java or C# is simpler/faster is arguable; C# is definitely better for cross-platform development Java is not an option for Visual Studio, C# is. Java has some great and free IDEs - like Eclipse, for example. Java's runtime is older, and its many implementations have had much longer time for optimization. Even Anders Hejlsberg admits that .NET's CLR is a bit behind on optimizations compared to Java's runtime implementations. Only recently they've added SIMD via RyuJit. C# is... a mix between C++ and Java. The concept of using a virtual machine, everything is an object, runtime type safely, etc, are all there. However, much like C++, C# allows you to go under the hood with unsafe, fixed, staticalloc, value types, P/Invoke, raw pointers, etc. It is not as efficient as C++, but at least you don't have to implement custom allocators for most of the things you do, as allocation for .NET (and I believe Java) is already (almost) a memory pool for everything. When you consider the more mature runtime(s) of Java and the ability for static allocation in C#... it is not easy to judge which is faster. The same goes for language beginner-friendliness. Java's been around for ages, and has stayed mostly the same. It is rock-solid language that has a lot of good, established books for it. Books of such quality are somewhat lacking for .C#. On the other hand, C# has been evolving to reduce boilerplate and make easy things easy, so it's constantly been getting easier. As a result of that, however, C# has a ton of features and keywords. Some things can be done 3 or 4 ways. Both Java and .NET have duplicating libraries as part of the standard package (it is worse with Java, as it has been around for longer); some basic things are missing in the Core Java, so you must use third-party libraries While Java is complie-once-run-everywhere... that doesn't hold up in real life. Only Core Java is supported on Android. SWT, one of the UI frameworks, some libraries (SWT) are quite buggy on some OS-es and slow to adapt new features. You can't embed Java in your application, while, with Mono, that is often done in games. Much less often than JavaScript or Lua, but still quite doable. With Xamarin, C# is much, much more portable than Java. When you say "cross-platform" - what does that mean? Mac/Linux/Windows? There's much more - Android, Windows Phone, iOS, BlackBerry, all the gaming consoles. You can use C# almost everywhere (I'm not a licensed PS4 dev, so I don't know if Mono compiles there) - whether directly via .NET, or embedded via , or via Xamarin's tools. Java can be seen on all major desktop and server OS-s, and on some embedded devices. To say that Android has Java is.. not correct. It is not a licensed implementation, and only Core Java works there; Java 8 is not supported, and Java 7 is supported only on KitKat+ devices AFAIK. I love both languages/environments. They are nice, modern, productive, evolving for the better (mostly). Since you've mentioned Visual Studio - use C#. You can use MonoGame, SharpDX, Unity, etc.


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- à person
à person, frz., auf die Person, den Kopf.
à person, frz., auf die Person, den Kopf.
A Person of Interest — Infobox Television episode Title=A Person of Interest Series= Season=2 Episode=23 (#45 overall) Airdate=May 18 2003 Production=E3220 Writer=Dick Wolf (creator) René Balcer (story and teleplay) Warren Leight (story) Stephanie Sengupta (story… … Wikipedia
Draw-A-Person Test — Smiling person (combined head and body) age 4½. The Draw A Person Test (DAP, DAP test, or Goodenough Harris Draw A Person Test) is a psychological projective personality or cognitive test used to evaluate children and adolescents for a variety of … Wikipedia
An Autobiography of a Person in the Spirit — Infobox Book name = An Autobiography Of A Person In The Spirit title orig = translator = image caption = author = Witness Lee illustrator = cover artist = country = United States of America language = English series = subject = Subjective… … Wikipedia
to go over the head of a person — Head Head (h[e^]d), n. [OE. hed, heved, heaved, AS. he[ a]fod; akin to D. hoofd, OHG. houbit, G. haupt, Icel. h[ o]fu[eth], Sw. hufvud, Dan. hoved, Goth. haubi[thorn]. The word does not correspond regularly to L. caput head (cf. E. {Chief},… … The Collaborative International Dictionary of English
Think of Me First as a Person — Infobox Film name = Think of Me First as a Person image size = caption = director = George Ingmire producer = writer = narrator = starring = Dwight Core (voice) Dwight Core Jr. music = cinematography = Dwight Core editing = George Ingmire… … Wikipedia
To give a person line — Line Line, n. [OE. line, AS. l[=i]ne cable, hawser, prob. from L. linea a linen thread, string, line, fr. linum flax, thread, linen, cable; but the English word was influenced by F. ligne line, from the same L. word linea. See {Linen}.] 1. A… … The Collaborative International Dictionary of English
To keep a person on a short leash — Leash Leash (l[=e]sh), n. [OE. lese, lees, leece, OF. lesse, F. laisse, LL. laxa, fr. L. laxus loose. See {Lax}.] 1. A thong of leather, or a long cord, by which a person may hold or restrain an animal, such as a falconer holding his hawk, or a… … The Collaborative International Dictionary of English
You Could Drive a Person Crazy — Infobox Television episode Title = You Could Drive a Person Crazy Series = Desperate Housewives Caption = Lynette angered over Tom s laziness. Season = 2 (2005 2006) Episode = 2 Airdate = October 2, 2005 Production = 202 Writer = Chris Black and… … Wikipedia
The Threshold of a Person — Infobox Television show name = The Threshold of a Person ID精英 caption = genre = Modern Action format = High Definition runtime = 45 minutes (approx.) creator = director = producer = writer = starring = Roger Kwok Yoyo Mung Patrick Tang Toby Leung … Wikipedia
To play into a person's hands — Play Play, v. i. [imp. & p. p. {Played}; p. pr. & vb. n. {Playing}.] [OE. pleien, AS. plegian, plegan, to play, akin to plega play, game, quick motion, and probably to OS. plegan to promise, pledge, D. plegen to care for, attend to, be wont, G.… … The Collaborative International Dictionary of English
To tar and feather a person — Feather Feath er, v. t. [imp. & p. p. {Feathered}; p. pr. & vb. n. {Feathering.}] 1. To furnish with a feather or feathers, as an arrow or a cap. [1913 Webster] An eagle had the ill hap to be struck with an arrow feathered from her own wing. L… … The Collaborative International Dictionary of English


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Sherlock Holmes and Dr Watson are hired to protect Sir Henry Baskerville, who has just inherited an estate on Dartmoor and is supposedly threatened by a ghostly dog which has persecuted his family.
Having reinvented British horror in 1957 with The Curse of Frankenstein, Hammer Films swiftly had house director Terence Fisher and new-minted stars Peter Cushing and Christopher Lee knock out versions of Dracula, The Mummy and Sir Arthur Conan Doyle's spookiest Sherlock Holmes tale.
Like other early Hammer horrors, Hound is a splendidly full-blooded period melodrama, richly-produced (it was the first Holmes movie in colour), gorgeously-costumed and incisively acted by a top-flight British cast. Peter Cushing's brisk, twinkling Holmes (less fussy than in his later television takes on the role) and Andre Morell's non-befuddled, resourceful Watson broke from the readings of the roles Basil Rathbone and Nigel Bruce had established twenty years earlier, opening the way for later revisions and reimaginings of the great detective and his sidekick.
Lee would seem to be stuck with the stooge role as the imperilled Sir Henry, paralysed with fear as a tarantula crawls up his arm, but actually gets more screen time and more emotional range than in his higher-profile monster roles. Hammer litter the supporting cast with wonderful British eccentrics like Miles Malleson as a dotty Bishop, John le Mesurier as the sinister butler of Baskerville Hall and Francis de Wolfe as a glowering suspect, while finding room for the studio's traditional smouldering continental cleavage in the person of barefoot Dartmoor girl Marla Landi.
Purists might object to the script's deviation from the novel – Hammer even dare to change the identity of the ultimate villain – but Hound has been done so many times that this version has an intriguing capacity to surprise.
More shocking and less cerebral, it's still a damn good mystery, with strong character support from Andrè Morrell as Dr. Watson and Christopher Lee as the last of the cursed Baskerville blood line.


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GMC automobile owners have come to expect a certain level of dependability when driving their Savana 1500 around town. Your GMC dealership isn't the only place to locate genuine or original equipment quality parts to repair your Savana 1500. While it may not be difficult to locate replacement parts for GMC vehicles, these days the necessity for nothing but the absolute best are required to repair your car or truck. The vehicle in your driveway symbolizes the best in class when it comes to all the vehicles in today's marketplace.
Without some key electrical parts, your engine wouldn't be able to stay running. Your GMC Savana 1500 alternator has a pulley that spins as the crankshaft spins because they are both connected by a drive belt. Inside that alternator, a constant supply of current for your car or truck is generated as a pair of metal claws and brushes spin around a coil; creating a powerful electromagnetic field. The energy from your alternator goes back to the battery and keeps it charged, while also supplying voltage to circuits that power your climate control system, stereo, headlights, and plenty more on your GMC Savana 1500.
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|New Bilibid Prison in Muntinlupa
Of the country's 7,107 islands, 1 can have a special purpose.
Sen. Vicente Sotto III said he would start his stint in the 17th Congress by reviving his proposal to have an "Alcatraz-style" prison island for convicted drug traffickers, who could allegedly still run their lucrative business from the national penitentiary in Muntinlupa City.
Sotto on Wednesday said he would refile his Senate Bill No. 3326 on July 1. The bill calls for the segregation of so-called VIP prisoners, who would otherwise be sent to the lethal injection chamber if the country is still imposing capital punishment.
If passed, he said, the bill would do away with the need to reimpose the death penalty on high-level drug lords, as being espoused by incoming President Rodrigo Duterte.
Speaking at the Kapihan sa Senado forum, Sotto said the proposal to reimpose the death penalty would not be retroactive and thus not applicable to convicted drug lords who continue to find ways to operate behind bars.
Even if there was optimism that the Senate measure might be passed in 3 to 5 months, Sotto said there was no assurance that the death penalty would be implemented because some groups would likely challenge it in the Supreme Court.
Still, he said, he intended to refile his bill in order to stop the continued operations of the drug convicts.
"Segregation is allowed by the Constitution," Sotto said. "If you segregate (high-level drug convicts) and establish a national penitentiary for high-level drug crimes, this will be more restrictive as they will be confined in 1 place and they can be watched closely."
"If they are confined in a rocky island in Palawan ... Alcatraz-style, they cannot operate anymore. There will be no phones, no cell sites."
This would be a big change from their current condition at New Bilibid Prison in Muntinlupa, which is also coping with overcrowding and "where a lot of things are happening," he said.
Source: Philippine Inquirer, June 16, 2016
Gabriela to join 'super majority' despite opposition to death penalty
Although it is joining the "super majority" coalition in the incoming Congress, Gabriela Women's party-list will still oppose President-elect Rodrigo Duterte's plan to reinstate the death penalty. Gabriela party-list Rep. Emmi de Jesus said the group is against bringing back capital punishment since the state of the country's justice system leaves much to be desired.
The revival of death penalty is 1 of the 3 priority measures of the Duterte administration, the other 2 being the shift to federalism and the lowering the age of criminal responsibility for minors.
Despite disagreeing with Duterte's stand on the death penalty, De Jesus said Gabriela and other progressive party-list organizations under the Makabayan bloc will be part of the super majority coalition led by the emerging dominant party, the PDP-Laban. She said their decision was borne out of optimism to give Duterte's administration a chance to make good on his promises.
However, the lawmaker maintained that their membership in the majority bloc is not tantamount to keeping silent on pressing issues.
Davao del Norte Rep. Pantaleon Alvarez, Duterte's choice as the next Speaker, said at least 200 lawmakers from various political parties have joined the super majority bloc in the House. Its size is expected to help fast-track the passage of the incoming administration's priority bills.
For his part, Ifugao Rep. Teddy Baguilat said he is hopeful that the minority bloc in the incoming Congress will actively do its role in holding the Duterte administration accountable no matter how small its composition will be.
"I hope the minority will become the fearless few," said the Liberal Party stalwart, who has expressed his desire to become part of the minority.
Alvarez earlier said he plans to reduce the membership of the House minority coalition to a "bitesize" of around 20 lawmakers.
Among the parties that have expressed interest in joining the minority is the United Nationalist Alliance of Vice President Jejomar Binay. LP, meanwhile, is in talks with PDP-Laban to join the super majority coalition.
Source: gmanetwork.com, June 16, 2016
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Why do you like or dislike this movie?
Uploaded: 2016-05-15 Rating: % / Votes
Description: Alice March is a sexy hottie babe with an awesome body. She is craving for a large meaty pole in front of her. So she started to tease it and suck it deep in her throat then ride that meaty pole in different position til her juices starts to flow


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IcoFX Software IcoFX 2.11 Multilingual + Portable | 26.93 MB
IcoFX is an award winning professional icon and cursor editor. It is an all-in-one solution for icon creation, extraction and editing. It is designed to work with ShiChuang XP, ShiChuang Vista, ShiChuang 7 and Macintosh icons supporting transparency.
Create icons and cursors
Create icons for ShiChuang and Macintosh. Support for ShiChuang Vista icons with PNG compression. Convert your Macintosh icons to ShiChuang icons and vice versa. Support for static and animated cursors. Create a favicon for your website or blog.
IcoFX Batch process multiple files
You can easily work with multiple files using the batch processing capability of IcoFX. Create, convert, extract or export all your icons or cursors with just a few clicks.
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With more than 40 effects at your fingertips, there's virtually no limit to the icons you can create. IcoFX features a collection of intuitive color correction tools. Using these tools you can fine-tune hue, saturation, and luminance, adjust color levels, brightness and contrast.
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You can quickly create layer based images using IcoFX. It allows you to rearrange, blend layers and change their opacity. This gives you more control, and you can more easily change the image in the future.
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You can easily convert your favorite images into icons or cursors, or icons into images. Supported image formats BMP, PNG, JPG, JPG2000, TIF and GIF. With IcoFX you can extract icons from other files, including ShiChuang Vista, ShiChuang 7 and Macintosh files.
IcoFX Resource editor
IcoFX gives you the possibility to create icon libraries or change icons inside exe files. You can also create cursor libraries.
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IcoFX features a full blown image editor with many useful tools. You can use different brush sizes, shapes, hardness, even blending modes when painting.
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With IcoFX's collection of selection tools you can quickly and easily select any part of your images. You can then edit and apply special effects to portions of your image, remove unwanted objects or cut out objects from one image and paste into another. Using the QuickMask you can use the painting tools to refine your selections.
Version 2.11 (12.05.2015)
+ Alt + [ and Alt + ] shortcuts to decrease/increase brush size
+ Copy Merged menu item to copy all the layers
+ Delete will not drop the selection in images, toolbar images and animated cursors
+ Duplicate image will duplicate also the selection
+ Images are saved in reverse order inside icons so that the thumbnail will look
good in ShiChuang Explorer
* [Fixed] Cannot change/replace icons in resource editor
* [Fixed] Some shortcut links were not dereferenced correctly
* [Fixed] Custom image size could not be larger than 512 in the Image Size dialog
* [Fixed] Files with multilple extensions (ex. icon.my.ico) were not correctly
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* Minor enhancements and bugfixes
Download From Nitroflare
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You must go forth to save Princess and destroy the root of all evil!
Use this security logo:
Freeware is computer software that is available for use at no cost or for an optional fee.
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Major Update


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The track-focused 1LE performance package package adds a Tremec 6-speed, FE6 suspension, and 20" wheels with sticky Goodyear 285's.
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2013 Chevrolet Camaro 1LE
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The track-focused 1LE package took the Camaro to a whole new level of performance. Setting the stage for the Z/28 and whetting the appetite of enthusiasts around the world!
Vehicle Info: 2013 Chevrolet Camaro
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text:
Question about Televison & Video
How do you change the bulbs in my tv? is it something i can do? the picture works but it is gradually going black each day.
Posted by garyroy on
chassis# is ptk169pfa, model #46ge944, manufactured in 1996.its a GE brand 46 inch. the peaple i bought it from about a year ago said they had the bulbs replaced about a year before i bought it, so making them new about 2 years ago. i have not done anything to it becouse i have no idea what to do.. thanks for your help...
Symptom does not necessarily indicate CRT's bad...........
Have you tried resetting the RGB screen controls?
What is the make / Model / service or chassis # ?
1) In customer menu, adjust all video controls to center,then
increase "picture" to 3/4
2)Locate focus/screen adjust block above chassis...adjust
RGB screen controls for best mixture = B/W tracking..
Check with customer color level at minimum..should look gray.
If you turn screen controls up too much,you will see faint
re-trace lines in picture.....once B/W looks good,put color level
back to middle...................................................T.
Posted on Feb 05, 2008
SOURCE: I have freestanding Series 8 dishwasher. Lately during the filling cycle water hammer is occurring. How can this be resolved
a 6ya expert can help you resolve that issue over the phone in a minute or two.
best thing about this new service is that you are never placed on hold and get to talk to real repairmen in the US.
the service is completely free and covers almost anything you can think of (from cars to computers, handyman, and even drones).
click here to download the app (for users in the US for now) and get all the help you need.
Posted on Jan 02, 2017
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Thanksgiving in America
Hotcourses editor and former international student Alejandra tells us about her experience celebrating one of the biggest holidays in the United States, Thanksgiving.
Hotcourses editor and former international student Alejandra tells us about her experience celebrating one of the biggest holidays in the United States, Thanksgiving.
Probably the biggest holiday in the United States, Thanksgiving Day in America is a time to offer thanks, of family gatherings, holiday parades and abundant meals... a lot of them!
It might seem odd to have a big holiday less than a month before Christmas but Thanksgiving has deep historical roots for Americans...
The whole tradition started when Pilgrims from the UK left British shores to embark on a dangerous adventure across the Atlantic towards the 'New World'. The trip on the Mayflower ship lasted 65 days only to be concluded by the landing on deserted land of merciless winters.
The Mayflower population was decimated during the first year after their arrival. The first Thanksgiving was celebrated on 1621, when the Pilgrims flourished with plentiful food sources, thanks in large part to the friendship and guidance of their neighbours: the Abnaki Indians.
Thanksgiving is a day for Americans to gather with friends and family, and give thanks (as the name suggests) for what they have.
Thanksgiving is a public holiday on the fourth Thursday of November each year. On the day, families and friends gather to have a big meal at lunchtime or in the evening. The most popular Thanksgiving dinner staples are a large roasted turkey, cranberries, sweet potatoes and pumpkin pie for desert. Consequently, the turkey production industry in the United States raises over 256 million turkeys every year!
Before the meal, families will sit down and watch an American Football game on television or even play a game themselves in their back garden. Mass public parades are also popular, complete with floats and much fanfare. The most well-known is the Macy Day's Parade in New York City.
Over the years Thanksgiving has become a cross-cultural celebration, observed not only by Americans but by other countries around the world such as Canada, Liberia and Puerto Rico.
'Black Friday' is the name given to the day following Thanksgiving where most major stores (physical and online) have massive sales and discounts on a range of products. It's an openly commercial event which has become increasingly significant in recent years for those searching for a bargain; but it's brilliant if you're looking for a new laptop or tablet for your studies. Black Friday signals the start of the Christmas season for retailers and often Americans will line up outside stores for hours to get in as soon as possible to grab a deal!
Many universities organise activities for international students on Thanksgiving Day since many domestic students will go home for the holiday. However, often international students will find that their new friends will invite you along to their family dinners though don't necessarily expect this or invite yourself! You can always gather with other international students or those domestic students who choose not to go home for the holiday, and have your own big meal.
If you haven't got any plans and you're feeling charitable, you can find out about local soup kitchens which will be preparing and serving food to the homeless and less fortunate. Volunteering opportunities look great on a CV, but you can also meet new people and go to bed knowing that you've made a difference in someone's life for that day.
"It is all about the Turkey and the marshmallows! .... But the best thing about it is that everyone goes home and spends time with their families. Everyone remembers the importance of family. I was brought along by my classmate to his family house and we ate loads. I even tried pumpkin pie for the first time... As an exchange student, I really didn't think Thanksgiving was such deal, but it is."
Sally, Scotland
"Everything is on sale! On Thanksgiving we went shopping during the day and then went for dinner with my friend. But in the evening all the shops are closed and the streets are as empty as ghost towns because everyone was in their homes celebrating Thanksgiving with their families.... it's like Xmas day anywhere else."
Wanvisa, from Thailand
"My host family took me to church with them and we had a special service. Nowadays, not many people see it as a religious celebration as it should be. But you could feel everywhere a sense of togetherness and friendship; my host family's neighbours invited us to have dinner at their house and basically spent the whole weekend eating non-stop!"
Rosalba, from Venezuela
Read more:
Find out how Christmas is celebrated abroad
Paul Ellett is the editor for Hotcourses Abroad. His role is to plan, produce and share editorial, videos, infographics, eBooks and any other content to inform prospective and current international students about their study abroad experience. When he's not thinking about student visas in Sweden and application deadlines, Paul is an avid fan of comedy podcasts and Nicolas Cage films.
'Study in the USA' eBookEnjoy what you've read? We've condensed the above popular topics about studying in the USA into one handy digital book.


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SD Card Reading Writing Module for Arduino (Works with Official Arduino Boards)
Free shipping To
If you think the price is too high, please click to apply for lower price
|Deep Blue
|SD card supports FAT16(FAT); Through programming, you can read and write to the SD card using your arduino
|Arduino DIY project
|Packing List
|1 x SD card module
All packages from DX.com are sent without DX logo or any information indicating DX.com. Due to package variations from suppliers, the product packaging customers receive may be different from the images displayed.
To enable volume discounts on this site, use coupon code: BULKRATE during checkout. You will see a discount applied at the bottom of the shopping cart. Competitive pricing is available. Contact us for details.
|3+ units
|5+ units
|10+ units
|US$1.87 shipped
|US$1.86 shipped
|US$1.85 shipped
What is Bulk Rate? BulkRate is a semi-wholesale system with items priced separately from retail. When you use bulk rates, a flat $1.70 registered air mail fee will automatically be added to your cart to ensure delivery of package. While BulkRate's intention is to offer cheaper prices when you buy in bulk, because it is priced separately it on occassions show a higher than retail price. That's why we ask you to enter BULKRATE as a coupon code to manually activate the rates. You can always opt not to use the bulk rates. If you are looking for wholesale prices please feel free to contact us.
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Share your reviews, photos and videos here!Review Program
nice price and good
Pros: good quality, robust, cheap and beautiful design. Cons: I have not found the datasheet to make it work
you can create a lot of projects with arduino board or raspberryPi board...easy to use and ottime manifacture
Ótimo leitor. Fácil de usar. Não tive nenhum problema em ligá-lo e acessá-lo. Boa qualidade. Recomendo.
Very good price. Very good quality. Worked with arduino uno clone once I figured out was connecting to pin 5 not pin 4 :). Seemed to work OK with breadboard and wires. The card loads/unloads with a spring which is nice. to... Read more
Works like advertised with the examples from the Arduino IDE. You just have to know that the "Clock" Pin is the one that is As... Read more
The module is cheap, it works as indicated and intended for SD card reading. This works on a Netduino too. As I am using a Netduino, I to... Read more
nice price and good
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