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Vitamin Shoppe
Consumer Complaints and Reviews
To all my international people DO NOT and I SERIOUSLY mean DO NOT buy from the Vitamin Shoppe. They are complete scammers/scoundrels. When placing orders they don't show you the amount till the end even, when you apply a coupon code you still don't see what or how much you're getting off. At first it showed me $31 total Canadian. Then I applied my coupon code and the total amount disappears. I'm like ok we'll see at the end... to find out the ** total almost is $70. PLS PLS PLS DO NOT PURCHASE ** from these pigs. Be aware. Sucks iHerb.com ran out. They are always my 1st choice even though I pay customs fees when my things arrive.
Ordered product on a Monday, needing it for a trip scheduled Saturday. Website stated product in stock, and est. ship date on same day as ordered. Checked status on Tuesday, was informed it would ship that day. Product did not ship, so I checked again on Wednesday; SOS, they said it was going out that day. Here it is Thursday, still has not shipped. Called again and get the apologies, but was told they'll ship today, next day air. (Will keep an eye on CC to make sure they don't bill for that.) Amazing in this day and age that I can order same product from Amazon, and get a shipping confirmation within a couple of hours. Sears and K-Mart learned their lesson the hard way, other Shoppes best take notice, or they will soon be in the dumpster, too.
Vitamin Shoppe advertises, sells and confirms over the phone the quantity of product you're buying, but ship smaller quantity. They say 16oz is what you're buying, they document the sale as 16 oz and ship you 14 oz. After being notified of the error, they continue to do the same thing and make no changes to product description on website. Raw Fit original has been on the website as 16 oz for months, but they ship 14 oz. Buy elsewhere and get what you pay for.
I went to the store in response to a "same day store pickup" order I placed; 2 days had since passed. I understood that this might be the case at minimum because their website warns you, if the request is made within 2 hours of closing time of your local store, the "same day" request might not be honored. (This would lead one to believe that at minimum, the Vitamin Shoppe is checking real-time in-store inventory, and will fulfill your order from said in-store inventory at your local branch; since there's not much chance that even a timely morning order placed to a store could be fulfilled by same-day evening, if the store has to have the order shipped to it from a different locale.)
Well, clearly this is not the case, as my appearance in-store on the second day, was greeted with "We never received that order." After which point I apparently had no recourse except to purchase the same item from their on-shelf stock. To be fair, I would later note that my spam filter had misplaced an email sent 90 minutes earlier from the Vitamin Shoppe apologizing for not being able to fulfill my online order; regardless of which, why? I have money in my payment source, and the Shoppe said the order was approved. They simply said I had to "Wait to be able to pick it up."
If they aren't ready to fulfill the order, don't email customers saying your order is approved. If I wanted to wait several days for the arrival of a single simple supplement, I'd have ordered from a place that doesn't boast 2-day in-store pickup, max. At least when one orders from Amazon they tell you when the package will arrive, thus giving you a chance to accept or deny their shipping timeframe before you press "buy". Very poor process on the part of the Vitamin Shoppe.
Hagerstown, Maryland branch is run by a very short angry man. Unlike all other locations he hides his free samples of protein and energy drinks in the back of his fridge like some kind of freak. They are normally set out in a cooler for customers to help themselves. I spend $4-20 a day at VS stores. This guy told me I wasn't allowed a sample as I had a sample the day before on a separate TRANSACTION. He told me no. I asked again and he said it cost him money... personally. Forget the 15 or 16 years of customer loyalty of $2,000-$4,000 yearly. These guys told me no repeatedly. It wasn't a joke. I'll just go elsewhere. Keep your samples. The few cents you saved cost you thousands.
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I was in the Burnside Portland, Oregon store today to pick up some **. The sales associate seemed very rude. She had black hair and was about 5 feet in height. When my change was handed back to me she "threw it" at me, while giving me rude looks as I left the store. Being a national nutritionist I used to send clients to your store, however in the future I am having serious reservations about using your store as a referral service for supplements and vitamins for my clients.
I don't appreciate being treated disrespectfully as a customer in your store and if this continues I will no longer shop at your store, and refuse referring my clients to your store. I have shared my experience with numerous online customer rating networks so they too may be warned about this behavior that is occurring at the Portland, Oregon Burnside location.
I order from here because of deals and the product I want is always in stock. I am done with it though, shipping is ridiculous!!! I can't track it. They take forever, and CS was useless!! Not once but almost every time! I will pay a bit more and order from elsewhere now.
Shipping is ridiculous to track. They ship partial orders without any notice and never reship the backordered. You get standard answers when you write customer service. Order anywhere but from here.
They claim their slogan to be "everyone matters". Hahah what a joke this crappy company is. Spent over $200 with them early April 2016, I know is not much but to me it's $200. Received my first order after a few days even though I did same-day store pickup, whatever. I got what I order so I didn't complain. Ending of April 2016 I ordered again to take advantage of their BOGO sale of their crappy brand, spent $127.06 waiting for the product. I get an e-mail saying that the order is cancel with no reason why. I call the number provided. I am told I am out of luck and can try to re-order as they can't tell me what happen. lol. This company is a joke, they have terrible customer service, sell really crappy supplements that they attach their name to sale BOGO deals and get upset when you question what happened with your order. I will never give this terrible company a dollar.
On April 22 at The Vitamin Shoppe located at 2205 N. Federal Hwy, Ft. Lauderdale 33305 I purchased two items totaling $50.98. This morning, April 23rd upon a review of my checking account, I found two pending charges for the exact same price of $50.98. The Vitamin Shoppe must have accidentally charged my account twice. No big deal... Let me give them a phone call and try to rectify it or ask if I need to bring in a copy of my bank statement. When I explained the dilemma to ** the manager on shift, his response was, "That's impossible, we can't double charge". In response, I suggested I bring in a copy of my bank statement showing the two pending transactions with two different transaction numbers from The Vitamin Shoppe.
He told me there's no need for that because there's nothing he can do to help me. Not once during our conversation did he ask for my name and information to at least look up my transaction. He suggested I call my bank and attempt to resolve it with them, at which I then stated, "This is why I shop with Amazon.com because they would have looked up the transaction, verified the situation and resolved it... making my shopping experience a smooth, happy experience."
** then became upset, argumentative and interruptive. I expressed my dissatisfaction with his behavior towards me as a customer and this will all go into my review of my shopping experience at their store, plus I'm going to use his behavior when I call The Vitamin Shoppe corporate office. ** hung up the phone on me. Hmmm... The Vitamin Shoppe charges me twice (accidentally) and owes me $50.98 and then I receive abusive attitude from the manager on duty and he hangs up on me.
How interesting is that? If I had a problem with a transaction with Amazon.com, they'd have been apologetic and extremely cooperative with me, thus making me feel as if I am a valued customer. Upon contacting The Vitamin Shoppe customer service, I spoke with a representative named Elley and explained my experience thus far. I was calm, but obviously a very dissatisfied customer. She apologized for my experience and told me I would receive a call from corporate on Monday as they are not in the office during the weekend. I do expect to be refunded the mistaken transaction funds, but I sincerely hope the manager ** receives some sort of disciplinary action and training in customer relations. An apology would be a good start. I will be holding off from submitting my review pending the outcome of our investigation...
April 27, 2016... It is now 5 days after my purchase at The Vitamin Shoppe and 4 days since I initiated my complaint with customer service at The Vitamin Shoppe. I did not receive a call from corporate Vitamin Shoppe in regards to my financial issue nor the abusive treatment from Ike the local manager. I instead initiated a call regarding both issues and was told my funds will be refunded. In regards to ** and his abusive customer relations skills... Well, I haven't been contacted by anyone from The Vitamin Shoppe which is indicative of a much bigger problem at The Vitamin Shoppe.
The Vitamin Shoppe clearly does not care about their customers. This is why their employees are completely unskilled in customer relations. Hence, this is why I do the majority of my shopping (spending my hard earned money) at Amazon.com... a company which clearly has a complete training department on customer relations. Amazon has the exact same products for $9 less with 2 day delivery which will be subscribed to for a very pleasurable monthly delivery. Thank You **. Thank you Vitamin Shoppe for a very long drawn out disastrous $50 shopping experience.
I purchased a supplement for $30 at the Vitamin Shoppe. When I returned home, I opened the jar to find that the foil seal had a huge hole in it - as though someone stuck a finger through it. I took the supplement and the receipt back the next day. They did not have the another of the exact supplement that I purchased, so I chose another brand. There was a price difference and I was owed money from the exchange. I was told that I could have a credit to the store, but not cash back (I paid with cash for the original purchase). The lady who works at the store is very helpful and informative but told me that since the original jar was opened, I was not able to get cash back. I went ahead and purchased other things to make up for the money that I was owed. For future purchases of this nature, I will go to GNC.
I received my award coupons approximately a month or two ago in the mail. I have a couple of accounts with them, one under my name, one under my son's name. I received another $25. award coupon in the mail to my surprise. So I went to Vitamin Shoppe and when paying and trying to use the new award coupon I'm told it has been used already. Turns out they sent out a duplicate coupon a month or two later in the mail just like the first time. The cashier said that it happens many times. Once you're online with people behind you, chances are you'll just tell the cashier, "No worries just ring me up". I believe this is exactly what Vitamin Shoppe is hoping for and that's why they are sending out duplicates so they can drum up business. We are the customers that are their bread and butter and this is how they are returning the favor. When I called customer services I pretty much got a, "Oh well" from them. These kind of business tactics cannot be rewarded!
Vitamin Shoppe advertises they have same day shipping if ordered by 6pm eastern. I placed my order Thursday night, so it should have shipped Friday. Today is Wednesday and I haven't received shipping info, so I checked VS website, which lead me to UPS. Tracking info is as follows (most recent scan on top): Secaucus, NJ, United States 11/24/2015 (Tues) 12:28 A.M. - Departure Scan. Secaucus, NJ, United States 11/23/2015 (Mon) 6:56 P.M. - Origin Scan United States 11/22/2015 (Sun) 5:07 P.M. - Order Processed: Ready for UPS.
My complaint isn't that it's taking 16 days for my order to arrive (and not the "2-6 days" they claim), but that VS states orders ship the SAME DAY. Since they had my order bright and early Friday morning, why did my package not arrive at UPS till TUESDAY NIGHT?? I ordered online to save time, but it looks like I'll have to go to the store to buy my products and then take this package back to VS for a refund. I will not be shopping at Vitamin Shoppe again, online or in the store. There are many alternatives to choose from, so why support bad business practices?
I ordered a shampoo and conditioner almost 2 months ago. They never mentioned anything about a back order when I ordered the stuff online but then later I only received the conditioner in the mail. Now, almost after 2 months I still have not received the shampoo. I called in to tell them how dissatisfied I was with the customer service but they couldn't care less. WILL NEVER USE THIS COMPANY IN FUTURE.
Service is ridiculous. My last order was on holding pending review almost week without tracking number.
I went to buy some protein, and I saw a couple of the Vega protein on sale 50% so got the 2 last one and 1 of the soy protein non-gmo $50% too. When I got to the register they told wasn't on sale. I showed them the sign and they told it's for the product on the side also a soy protein, so I took one of those and the price was regular. They told "I am sorry we messed it up." But they don't gave me the discount. I have to look for other protein. Very sad. :(
Warning you're paying for placebos. I bought a thyroid supplement "kelp" that was supposed to help increase iodine. The recommended daily amount for iodine is 12 mg daily. Each pill only contains 250 mcg. You need 1000 mcg to equal 1 mg. I can get more iodine just by eating iodized salt for a fraction of the price. Also their protein shakes are double the price you can find elsewhere.
We have ordered several hundreds of dollars via online stores. Have ordered 2 times from this outfit, as I thought it cannot be so bad a second time. It was worse. The pricing is good, however the Customer Service is the worst I ever dealt with. Next day shipping? Will not happen... Next week shipping? If you are lucky that may happen. Took 8 days from order date until receiving a tracking number..... (Free advice) If you don't like to get aggravated stay away from this company.
Beneflex is advertised on their website as costing $47.99, purchase it monthly. Last week was at the store and was charged $50.99. Why? They say because from week to week, the prices change. How about that? I just cannot wait to go there and see what the next surprise price will be...not. I explained the matter to the salesman there and he was just too busy unwrapping products to be placed on the shelves to even listen to me. Go to Drugstores.com now... Get the price that is posted on the site, which is less and they deliver it for free to my home in a couple of days.
Called the store just today to inquire again as to why this happened. A man on the other end said the same thing... Prices can change from week to week. I was offered a refund but gee, I had already opened the bottle. So this is a 'hit or miss' shopping experience. This is a product I purchase every month. I don't need to play stupid games with prices. No thank you.
Purchased two deodorants on 1/31/15 for myself and daughter. The deodorants are actually causing high body odor than the usual. I called the 12 4th Ave Store to stated I would like a full refund for the item not a Merchandise Credit and he (the Manager) insist upon providing a Store Credit. The company sells products that don't work and then you force the consumer to continue shopping at your store with a Store Credit instead of offering a refund. I understand it is a hygiene product. However, they are insured for faulty products. This is my first time shopping with them and my absolute last. Will post this on all my Social Media pages.
The site was unresponsive to sending an email to reset password as they said the would. I received an email regarding a sale. The item was only to be on sale till midnight of that day that I read the email. It was only for online purchase. I was not able to log in to make the purchase without my password. I received an automated reply that someone would be respond within 24 hours. That automated response came through and a response to reset the password should have also. I was pretty upset because the sale item was 50% off and I was not able to order it.
I also had a very bad experience with them. I placed an order over the phone, because their site was down. Next day I got a confirmation e-mail with my order which had completely wrong name and address. Somehow my debit card was charged, even the name, billing and shipping name were wrong. That's very strange. I wasted 2 hours, calling them 3 times to fix my order. They would still make mistakes in my name and address. Those people do not care about service or their customers. I will never again order from them. Such a bad company.
I ordered four bottles of 32 oz UDO oil on 9-29-2014. On 10-10-2014 the package arrived at my post office with oil dripping out and glass rattling in the box. I refused the box and came home and called the vitamin shoppe. I was given a replacement order number and was assured the replacement items would be shipped immediately. By 10-30-2014 I had not received the replacement order and again called the vitamin shoppe and was told the replacement items were never shipped. Once again I was given a replacement order number and was assured the items would be shipped overnight. By 11/4/2014 I had not received the order. Once again I called the vitamin shoppe and now requested a refund. The box showed up today 11/6/2014 at my post office with oil leaking out and glass rattling in the box. I refused the box. By my count now I had received 12 smashed UDO oil. No wonder the shares are dropping. DO NOT ORDER FROM THIS BUSINESS.
Very bad customer service. I ordered 2 products since October 3 and I was supposed to receive my package 3 weeks ago. However, I only received one of the products. The company had not provided me tracking number or any shipping information of this product, and it is exactly 1 month since the day I purchased it. When I contacted them recently, they said my products was back-ordered (Well, I don't mind waiting for it but they should have let me know about its delay). I cancelled my product. No solution offered! Never buy here again or refer anyone buy here!
In the past, I have written 2 reviews about vitamin shoppe products and cannot find the reviews on their website so I am guessing reviews are removed if not approved. I had terrible headaches after using VS stevia. It took months to figure out what in my diet was causing these terrible headaches and finally figured out it was VS brand stevia. Prior to that I had a review about another product and that review disappeared. Now I am questioning VS brand Melatonin. I still shop at the local VS store but I no longer buy any VS products.
I contacted Roxy and Kathy concerning non-delivery.. They did nothing for five days. Finally Kathy put me on hold for 30 minutes telling me I had no alternative if I wanted a refund. Finally came back online and supposed to get refund in two weeks. Stay away from these people. Very poor customer service and products do not get delivered and no explanation given.
I have ordered supplements 2 weeks ago and haven't received them yet!!! How long does it usually take... This is my first time to order from Vitamin Shoppe - If I don't receive my supplements soon then I will never order from them again ever.
6/2/2014: Merchant advertised free shipping on ALL orders. Website processed order and AFTER accepting my credit card info, it added shipping & charged it to my credit card! Took several days of emails to rectify that issue. 6/7/2014. No goods received. Phoned 866-293-3367. Automated system said should arrive by 6/9/2014. 6/16/2014. No goods received. Phone merchant, spoke to agent who apologized, said it was lost by post office and promised to ship replacement by UPS for delivery 6/17/2014. 6/17/2014. No goods received. Phoned merchant for 3rd time. This time they said order was not processed! IMHO, VitaminShoppe.com is an absolute FRAUD and should be shut down or heavily fined by FTC.
Do not use Vitamin Shoppe Online. I am a fan of their stores but their corporate on line customer service truly could not be worse. I received supplements HOT - not warm - HOT, compromising the effectiveness of all the supplements I bought. This all had to do with the way they ship their supplements without any insulation. When I emailed them to ask for a refund and a return tag, they promised me IN WRITING that they had sent a call tag AND had processed a refund for me.
I had to ask for a call tag twice and then they NEVER processed the refund for a full 20 days AFTER they had promised they had and AFTER I demanded proof from them that they had processed the refund - and yet they still never offered proof or an apology. This is about 17 emails later. I did finally get the refund, without apology and without any acknowledgement that they had made absolute statements that things had been done that were never done. It took stating that I would contact the Better Business Bureau to get my refund. STAY AWAY!!!!!
I went to the VS in Deerfield Beach to look for a product that I have bought there before, knowing they were a smaller store and did not have everything in stock. Needless to say, I could not find the product and the salesperson had no idea what I was talking about. I decided to drive to the Pompano Beach location about 3 miles away as they have a bigger selection. Of course, they were out of the product and the manager was not helpful. In fact, he walked away during the middle of our conversation to help another customer not even excusing himself.
I then asked if he could look it up in the computer and he said he could but products change every month. I asked him if this is the way he treats all customers and he said, "I don't know what you mean." I asked if I could get the manager's name and he said he was the manager. I told him I was not coming back and he lost a customer. He responded by saying, "What do you mean by a good customer?" Best part is I left and ordered the product 50% off online and saved over 25. I will never set foot in one of their stores again. Thanks for listening to me.
Vitamin Shoppe Company Profile
- Company Name:
- Vitamin Shoppe
- Website:
- http://www.vitaminshoppe.com/


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4 days ago I got botox injected into my jaws to make them smaller and slimmer. I haven't felt any difference or soreness or anything different with my jaw. I am concered that it isn't working. When will I notice a difference?
Is my Botox Jaw Reduction Working?
Doctor Answers 7
Botox to reduce Jaw width
If your jaw muscles give your face a wide or square appearence then Botox into the muscles can slim the area. Once the Botox is injected it takes several months and likely one or two additional botox treatments to see the final result.
Learn more: http://www.8west.ca/knowledge-base/refresh/understanding-botox/
Botox works well for Jaw Reduction
Botox can work very well to reduce the square appearance to your jaw. As a muscle "relaxer", it works by reducing the volume of the Masseter muscle. This is one of the large muscles involved in chewing, and it's size simply adds to the fullness in front of, and below the ear. There are several important things to consider when using Botox to decrease the square, bottom heavy look to your face. First, it will only help to slim the look of the jaw if the size of the Masseter muscle is causing the heaviness that you don't like. If it is the jowling we see with age (caused by the cheek tissue that has started to descend into the bottom half of the face) that is causing the heaviness in the bottom of the face, and not the size of the Masseter muscle, then Botox is not going to work. Secondly, Botox takes up to 10 days to take full effect and it simply may not have been enough time since your injection to see a noticable difference. Third, there is a certain amount of finesse involved with this type of injection. You want to relax enough of the muscle to get the slimming effect but not so much of the muscle that you are not able to bite down hard enough to eat normally. It is much better to under-inject than over-inject. Your doctor learns from each injection how much Botox is actually needed and over what area he or she needs to inject the Botox, in order to get the desired result. It may simply be that you have not notced the result you are looking for because you will need a little bit more Botox or will need a larger part of the muscle injected. It does sometimes take several injections to fine tune the technique for your particular anatomy. Be patient. If the results are not what you want, you may need to work with your doctor to help with this fine tuning proccess.
Jaw Reduction with Botox works well but takes time
Botox can be placed into the muscles of the jaw to reduce the appearacne of the jaw angle. These muscle are called teh masseter muscles and the Botox weakend them adn makes them shrink over time. This works very well, but it can take several treatments to see significant difference. Remember, the Botox can take a week to start working and then the treatment needs to be repeated every 4-6 months for about a year to see much improvement. Jaw reduction with Botox has become a very commonly requested procedure in my office, particularly with my asian patients.
You might also like...
Botox in jaw line
Botox injected into the jaw line to reduce masseter hypertrophy takes several treatments repeated over a year or twos time to see a good effect.
Botox in the jaw takes time to work
Botox in muscles around the jaw to shrink them works differently than botox in other areas of the face. The best way I can describe it is by comparing it to the effects of a muscle in the arm after being in a cast for a few weeks. When the cast is removed, the arm looks small because the muscle shrinks or atrophies from not using it.
When placing botox to shrink the muscles around the jaw it works similarly. The goal is prevent part of the muscle to move, and it will slowly shrink. So at 4 days, I would not expect you to see a change. It will take a couple of weeks for you to see a change and it will be gradual.
Botox in this area should not affect function. You should not feel weak in chewing, soreness etc. That would be abnormal.
I think you are doing well.
I hope this helps!
I hope this helps!
Wait to see results
Learn more: https://www.edelsteincosmetic.com/
Botox for jaw definition
Not all people will get better defined jaw lines from botox. If there is a pulling of the neck muscles (the platysma) which is making more of a jowl, then Botox can help shape the jaw line. If there are hypetrophic masseters (chewing muscles) then Botox may help make the jaw line look finer.
Learn more: http://www.thenyac.com/botox/index.html
These answers are for educational purposes and should not be relied upon as a substitute for medical advice you may receive from your physician. If you have a medical emergency, please call 911. These answers do not constitute or initiate a patient/doctor relationship.

subset: commoncrawl


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Construction will close a stretch of Prytania Street for an entire year, according to the U.S. Army Corps of Engineers.
Starting April 21, Prytania Street will be closed between Joseph Street and Nashville Avenue in both directions, due to culvert installation.
Thru traffic is being diverted to Nashville Avenue.
The construction is related to the Southeast Louisiana Drainage Project.
All work on that project is scheduled to be finished by 2018.


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Another Day in the Life of Early Dementia A Dementia Story of Love Series
by Marijo Phelps
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At least Mom and I had come to an agreement that she was not to call me at work unless it was a hospital type emergency.
She left voice mails at my home phone and I could collect them when I had a break.
At this point in time I was working 32 hours a week. Mick and I were keeping up our home and the folk's home which Mom wasn't ready to sell yet AND visiting the folks at 2 different facilities.
Many mornings I went in to feed Dad his breakfast. Hum. If we'd have had kids when we first married they'd be teenagers by now…..maybe there is a reason I never got pregnant and we didn't have children.
I got a voice mail from Mom wanting to move Dad to the facility he'd been in before NOW.
Lord, help us!
Ah, Lord God, nothing is too difficult for You – melt/meld Mick and me together in Your love….
Touch Mom and Dad….
Help me with a regular quiet time, praise, prayer and sitting at Your feet….
The weekend was terrible with Mom wanting to move Dad, because a resident's dog came into his room after she left the door open? She is not listening to reason. I was in tears and she said she'd no longer be responsible if anything happened.
We were hiking and the Lord showed me Moses (Dad) and Aaron and Hur (my sister,Colette and me and our husbands and prayer back up people) then how Aaron and Hur held up Moses's arms and he had victory. AND that Mom was released from responsibility and it was being transferred to us. My sister, Colette had gotten the same illustration from the Lord and had shared it with Mom unbeknownst to me.
Exodus 17:12
When Moses' hands grew tired, they took a stone and put it under him and he sat on it. Aaron and Hur held his hands up—one on one side, one on the other—so that his hands remained steady till sunset. (NIV)
I was the one in closest proximity so I was the one who got "I AM the WIFE, you are the daughter, I am in charge…" from Mom.
It was then I had to gently tell her (she and I are both old RNs) that Dad didn't even have a bedsore though he was in diapers and that I did not think he should be moved, neither did my sister. He was getting excellent care there and he didn't want to move again.
"If something BAD happens, it is your fault…."
I could only draw her close and give her a big hug and tell her that I loved her.
I got a call the following day from "Two Men and a Truck Moving Company" telling me that Mom told them I'd write a check and they had just finished moving her to asnother facility she'd been talking about. For the moment, Dad was safe in the facility where he was getting such good care.
(C) Marijo Phelps all rights reserved. Use with with proper credits.
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Member Comments
You left me wondering where your mother was moved to? Hopefully they told you(the moving company) Very interesting write anyway!
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My son received a 3 day eviction notice for past due rent. Can they legally evict his family in 3 days? They have not paid the rent because the landlord refuses to clean up the mold in the basement and they will pay it once it has been cleaned up.
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Do you mean a three day rent demand or an eviction notice from the Sheriff? A rent demand is before the landlord sues the tenant in a nonpayment case. In the lawsuit the tenant presents defenses to the landlord's lawsuit. A defense based on the landlord's failure to repair is allowed by the New York State statutory Warranty of Habitability.
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Nothing has been presented from the courts. Just from forms she has downloaded and presented. Her son came and took some things from the basement that was her moms and he also took some things of theirs as well. They now have a 30 day notice and the landlord is showing the apartment to others. Thank you for the information and links.
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text: McCall's 6777; ©1979; Misses' Skirt: Front wrapped skirt (without side seams( has soft front gathers, hooked waistband, top-stitch trim. Contents[show] Links to reviews/blog posts Edit Sources/Vendors Edit Gallery Edit [insert your photos of this pattern made up] Wishlist Edit Retrieved from "http://vintagepatterns.wikia.com/wiki/McCall%27s_6777?oldid=757500" Ad blocker interference detected! Wikia is a free-to-use site that makes money from advertising. We have a modified experience for viewers using ad blockers Wikia is not accessible if you've made further modifications. Remove the custom ad blocker rule(s) and the page will load as expected. Categories: Vintage Sewing Patterns McCalls 1970s Skirts McCall's 1979 90 Minute Fashion Wrap Skirts Gathers Hook and Eye Closure Topstitching Add category Cancel Save


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Study of the Near-Surface Stress around Cu-filled and CNT-filled through silicon vias
Project Description
The technology of through silicon via (TSV) is one of the most promising enablers for 3-D integration of circuits and systems. By providing direct die-to-die connections to form stacked structures in 3-D integration, better electrical performance and lower power consumption can be achieved [Knickerbocker, 2008] [Garrou, 2008]. Copper is widely used as the via-filling material because copper is compatible with the back-end of line (BEOL) processes along with appropriate electrical and mechanical properties. However, due to the relatively large mismatch of coefficients of thermal expansion (CTE) between silicon (2.3 ppm/⁰C) and copper (17 ppm/⁰C) [Jiang, 2013], embedded Cu TSVs in silicon ICs can induce substantial thermo-mechanical stresses during temperature ramps in fabrication. The TSV-induced stresses can cause undesirable mobility shifts in devices through the piezoresistivity effect [Thompson, 2006] [Karmarker, 2009] and reliability problems such as copper via pumping and interfacial delamination [Ranganathan, 2008] [Selvanayagam, 2009] [Lu, 2009] [Lu, 2010] [Ryu, 2011].
Recently, carbon nanotubes (CNTs) have emerged as an alternative TSV filling material due to its superior thermal conductivity (k) and low electrical resistivity (ρ) [Sinha, 2010]. It was reported that even air-filled CNT bundles had conductivities a few times higher than Cu [Abdul Kadir Kureshi, 2009]. Due to the negative axial CTE of CNTs [Sinha, 2010], it is expected that CNT should have different thermomechanical behaviors during the thermal processes compared with Cu, which may overcome the reliability problems such as via extrusion and interfacial delamination caused by Cu-filled TSVs. However, the stress field around CNT-filled TSVs has not been studied well.
Raman spectroscopy-based temperature dependent stress study was first used in our recent work [Zhu 2015]. Together with stress simulations, that work provided evidences that the near surface stresses are not only from the CTE-mismatch effect, but also from the pre-existing stress before Cu filling [Zhu 2015]. In this paper, this approach was further used to study the near surface stresses around Cu-filled TSVs, Cu-etched TSVs, CNT-filled TSVs and void vias without filling. The comparison between void vias and filled vias enabled us to prove our hypothesis on the "pre-existing" stress in Ref. [Zhu 2015]. Moreover, different stress components are compared for Cu-filled and CNT-filled TSVs.
Faculty Supervisor(s)Guangrui.Xia
Research Area(s)


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The trend toward smaller devices and feature packed equipment and machines has provided revenue and profit momentum for microcontroller maker Microchip Technology (NASDAQ:MCHP). But, semiconductors are typically seasonal and Q4 is historically the weakest quarter for microcontroller maker Microchip Technology.
Microcontrollers are the draft horses of the semiconductor world. They help devices run cooler and use less power. In a universe where next generation consumer and industrial devices and machines require far more monitoring, analysis and power to meet our insatiable appetite for feature rich applications, developers are embracing microcontrollers as a low cost solution in everything from cars to smart phones.
Distributors bulked up on Microchip inventory in Q1, 2010 ahead of growing demand. As a result, they exited Q1 with 41 days of inventory, the high end of their historical norm. Through Q2 and Q3, 2010, distributors worked inventory levels lower, finishing Q3 at 31 days, the low end of the historical norm. Given Q4 is typically the weakest quarter for Microchip, its unlikely distributors were willing to make big inventory bets.
However, the distributor headwind exiting Q4 will shift to tailwinds in Q1 as distributors begin to model forward demand from rising car, industrial equipment and next generation phone and tablet product sales.
Automakers have stashed more features in dashboards and under hoods, driving industry demand for microcontrollers higher as auto sales gain momentum. Edmunds estimates domestic auto sales are running at a 12.8 million unit annualized pace in January, better than December – a historically strong month for sales. Since most new cars hitting dealer lots packed with electronic features, demand for Microchip products is likely to be strong again in 2011.
Industrial equipment sales will also boost microcontrollers demand this year. Manufacturers are restarting lines, as evidenced by manufacturing capacity utilization moving up to 73.2% in December. Manufacturers are generating robust cash flow, thanks to recession era cost cuts, which supports spending on next generation, feature-packed industrial equipment.
Additionally, smart phones, tablets and other small consumer devices continue to boost microcontroller demand. As devices come to market, feature competition increases, boosting the demand for products, including 16-bit microcontrollers.
Microchip responded to strong sales growth last year by ramping production. In Q3, production was "above-normal", running 90-95% or more. As production increased, margins improved to 58.9% of sales from 54.4% the prior year. Stable pricing and higher production allowed Microchip to guide future margins back toward 61% over time and it will be interesting to see how this shaped up in the seasonally week Q4.
Since Microchip controls its own production and design, and shares its architecture across its microcontroller and non-volatile memory products, they generate better margins and faster product development – important for maintaining pricing power.
The company enhanced its product pipeline in April with its acquisition of Silicon Storage Technology, Inc., spending $353.8 million to get SST's patent portfolio and SuperFlash product line - technology Microchip will incorporate into future microcontrollers. The deal will add $0.32 to non-GAAP earnings for 2011, up from the company's initial $0.14-0.18 estimates, and will add $0.40 to 2012.
In total, the company sold 168% more units in Q3 than it did in Q3, 2009 and 181% more units in Q2 & Q3 than the prior year and generated 67% of its Q3 revenue from microcontrollers.
Q4 is typically Microchip's weakest quarter with the company's book-to-bill entering Q4 at a meager 0.87. Low channel inventory and seasonal cyclicality suggest improvement in Q2.
Slightly more than half of Microchip's sales come through distributors, however, no one distributor accounted for more than 10% of sales last quarter. We've seen signals distributors were unwilling to buy in Q4, as evidenced in Cree Inc (NASDAQ:CREE) and Linear Technology Corp (NASDAQ:LLTC) Q4 earnings reports. However, distributor sluggishness may not be as pronounced at Microchip as with other semi plays given the low levels of distributor inventory ending Q3. If distributors did balk in Q4, weakness can be attributed to a broader seasonal inventory correction and any sell-off will provide a nice entry point for investors.
In the meantime, investors will be paid to wait as Microchip currently pays a 3.7% yield, paid for by robust earnings growth. The company has plenty of dividend boosting and M&A powder too, with $7.38 per share in cash. Despite having beaten the Street in each of the past four quarters, short sellers remain too exposed. Short interest stands at 8 days to cover and provides a floor for any downside.
Disclosure: I have no positions in any stocks mentioned, but may initiate a long position in MCHP over the next 72 hours.


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Saturday, March 11, 2017
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Fresh Tomato, Basil Grilled Cheese Sandwich
READY IN: 8mins
Recipe by Rita1652
This is a low good fat version of a grilled cheese seasoned with fresh and dried herbs and garden fresh tomatoes. I used a regular pan but for ease you can use a nonstick pan.
Top Review by Lucky in Bayview
Yum! What's not to love. I used butter as well as olive oil. Thanks for posting. I'm already looking forward to my next sandwich.
See Discussion:29 Reviews 3 Tweaks
Ingredients Nutrition
- 2 slices bread
- 1 teaspoon olive oil
- 1 pinch dried Italian seasoning
- 1 1⁄2 ounces sliced low-fat cheese
- 2 slices fresh tomatoes
- 2 -4 fresh basil leaves
- pepper
Directions See How It's Made
- Mix oil and dried herbs and spread on 1 side of both slices of bread.
- Preheat non stick pan to medium heat.
- Seasoned side down add slice of cheese, tomato, fresh ground pepper, basil and other slice of cheese topping with second slice of bread seasoned side up.
- Place in pan with a weight on it and cook for 1 minute till browned flip and cook for an other minute till cheese is melted.


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Left, Axial inversion-recovery magnetic resonance image showing the typical location of the midoccipital gray matter voxel; note a discrete hyperintense white matter lesion adjacent to the right posterior horn of the lateral ventricle (white arrow). Right, Coronal T2-weighted magnetic resonance image showing the left temporoparietal gray matter voxel; note also a discrete hyperintense white matter lesion in the subcortical parietal brain region (white arrow).
Proton magnetic resonance spectroscopy from the temporoparietal gray matter voxels of a healthy control subject (upper spectrum), a patient with myotonic dystrophy with 173 cytosine-thymine-guanine (CTG) repeats (middle spectrum), and a patient with myotonic dystrophy with 1140 CTG repeats (lower spectrum). Significantly increased levels of creatine (CR), choline-containing compounds (CHO), and myoinositol (MI) are observed in the subject with a higher number of CTG repeats. GLX indicates glutamate/glutamine; NA, N-acetyl compounds.
Regression analysis between the metabolite concentrations and the trinucleotide (cytosine-thymine-guanine [CTG]) repeats. CR indicates creatine; GM, gray matter; and MI, myoinositol.
Chang L, Ernst T, Osborn D, Seltzer W, Leonido-Yee M, Poland RE. Proton Spectroscopy in Myotonic DystrophyCorrelations With CTG Repeats. Arch Neurol. 1998;55(3):305-311. doi:10.1001/archneur.55.3.305
© 2017
To seek cerebral metabolite abnormalities in patients with myotonic dystrophy and to determine whether the degree of cerebral abnormalities (measured by proton magnetic resonance spectroscopy) correlates with severity of the genetic defect (measured by trinucleotide repeats).
Fourteen patients with myotonic dystrophy were compared with 24 healthy control subjects.
A university-affiliated medical center.
Compared with healthy subjects, patients with myotonic dystrophy had elevated levels of myoinositol (+19% in the occipital region and +12.9% in the temporoparietal region), total creatine (+7.6% and +6.8%), and choline-containing compounds (+21% and +7.7%). Furthermore, the creatine and myoinositol peak areas correlated with the number of trinucleotide cytosine-thymine-guaninen (CTG)n repeats from leukocytes, especially in the temporoparietal brain region (r=0.76; P=.004).
Neurochemical alterations observed with proton magnetic resonance spectroscopy are proportional to the cytosine-thymine-guanine repeat size. Increases in myoinositol and creatine concentrations may be caused by increased glial content, while elevated levels of choline-containing compounds are most likely caused by increased glial content and cell membrane abnormalities. Proton magnetic resonance spectroscopy is a powerful noninvasive tool to study brain biochemistry, which may reflect the extent of neuropathological involvement in patients with myotonic dystrophy.
MYOTONIC dystrophy is a progressive multisystem genetic disorder with an abnormality on the long arm of chromosome 19.1,2 The genetic defect consists of an excessive trinucleotide repeat—cytosine-thymine-guanine (CTG)n, which renders the defective production of myotonin, an inferred substrate of the myotonic dystrophy protein kinase.3- 5 A gain of function by the myotonic dystrophy protein kinase RNA and effects of the CTG expansion on a candidate flanking gene, myotonic dystrophy locus–associated homeodomain protein, may also contribute to the pathophysiology of myotonic dystrophy.6,7 The disease is characterized by myotonia, distal muscular weakness, and a variety of systemic disorders including cataracts, cardiac conduction defects, sleep apnea, endocrine abnormalities, and cognitive impairment.8 However, the clinical expression of the disease and the age at onset of the illness are highly variable. Between 25% and 70% of these patients are intellectually impaired,9,10 but the cause of the cognitive deficits is unexplained.
A variety of cerebral abnormalities, including cognitive impairment, abnormal neuroimaging findings on computed tomography, magnetic resonance (MR) imaging, single photon emission computed tomography, positron emission tomography, and neuropathological findings, have been reported in patients with myotonic dystrophy. Neuropsychological tests have shown lowered global intelligence (IQ) and personality changes11- 14 and, in particular, difficulties with visuospatial function and "frontal lobe" tasks.15- 17 The more severe cases demonstrated alterations of language and memory.14,18 Neuroimaging studies have shown abnormalities such as a higher prevalence of periventricular hyperintensities on MR imaging,13,19- 21 cerebral hypoperfusion on single photon emission computed tomography,18 and cerebral hypometabolism on positron emission tomography22 in these patients. Neuropathological examination of brains of patients with myotonic dystrophy found neurofibrillary tangles,23,24 with abnormally phosphorylated τ protein25 and intracytoplasmic inclusions.26 Taken together, these findings clearly demonstrate that brain abnormalities occur in addition to the neuromuscular involvement in myotonic dystrophy.
Magnetic resonance spectroscopy (MRS) can measure in vivo cerebral biochemistry and may help to further elucidate the cerebral pathophysiological characteristics of the disease. This study aimed to evaluate possible cerebral metabolite abnormalities in patients with myotonic dystrophy by means of proton (1H) MRS. We also determined whether the genetic abnormalities, as measured by trinucleotide repeats, correlated with metabolite levels in the brain.
Fourteen patients with a clinical diagnosis of myotonic dystrophy (8 men and 6 women, aged 37.8±2.7 years; Table 1) and 24 healthy control subjects (14 men and 10 women, aged 39.6±2.4 years) were consecutively recruited and studied with MR imaging and localized 1H MRS. Each patient underwent a screening evaluation that included medical and family histories; physical and neurologic examination (including a Folstein Mini-Mental State Examination27); electromyography; and an extensive laboratory battery, including complete blood cell count, routine chemistry studies, measurement of serum creatine (CR) and creatinine, thyroid panel, and measurement of fasting glucose and insulin, estrogen or testosterone, and serum and urine cortisol. Each patient with myotonic dystrophy also had DNA analysis for the CTG trinucleotide repeats by methods previously reported with polymerase chain reaction amplification and Southern blot analysis of restriction endonuclease digested genomic DNA.28,29 The myotonic dystrophy analysis, as performed in this study, is greater than 99% accurate and identifies greater than 99% of all myotonic dystrophy mutations. Before the study, each subject and his or her guardian received a verbal description of the study procedures and signed an informed consent approved by the Human Subjects Institutional Review Board at Harbor-UCLA Research and Education Institute, Torrance, Calif.
Each patient and subject underwent MR imaging to assess possible structural brain abnormalities. Both MR imaging and 1H MRS were performed on a clinical 1.5-T scanner (Signa 5.4, General Electric Co, Milwaukee, Wis) with the use of a quadrature head resonator. The examination began with the acquisition of a sagittal T1-weighted localizer (echo time [TE], 11 milliseconds; repetition time [TR], 500 milliseconds; 4-mm slice thickness; 1-mm gap; 24-cm field of view), followed by a coronal fast double spin-echo sequence (TE1, 17 milliseconds; TE2, 102 milliseconds; TR, 4000 milliseconds; 5-mm slice thickness; no gap; 24-cm field of view). Finally, an axial fast inversion recovery scan (TE, 32 milliseconds; inversion time, 120 milliseconds; TR, 4000 milliseconds; 3.5-mm slice thickness; no gap; 24-cm field of view) was performed.
The 1H MRS was performed in 2 cortical regions: the midoccipital gray matter and the left temporoparietal gray matter regions (Figure 1). Voxel sizes ranged between 3 and 5 cm3, depending on the individual anatomy of the subject; voxel sizes and location were carefully chosen by one of us (L.C.) to ensure consistent placement and to ascertain that each voxel contained primarily gray matter. After shimming and optimizing the water suppression, data were acquired by means of a double spin-echo sequence, point resolved spectroscopy (PRESS),30 with TE of 30 milliseconds, TR of 3 seconds, 128 averages, 2048 time points, and 2.5-kHz band width. The PRESS sequence was optimized for the chosen echo times and locations.31 To avoid the ambiguities caused by the use of metabolite ratios, metabolite concentrations were determined.32,33 Briefly, the T2 decay of the unsuppressed water signal from the PRESS experiment was measured at 10 different echo times (from 30 milliseconds to 1.5 seconds; TR, 20 seconds). The signal from an external standard consisting of pure water also was acquired. This made it possible to determine the compartmentation within the selected volume (partial volumes of cerebrospinal fluid, visible brain water, and an MR-invisible compartment) and to calculate absolute metabolite concentrations corrected for the partial volume of cerebrospinal fluid. This approach yielded interindividual variations of about 10% for the major peaks. Furthermore, this procedure showed an intrasubject variability of 3% for measurements of CR and 8% for the measurements of choline-containing compounds (CHO).
The data were transferred to a SPARC 2 workstation and processed by means of the GE spectroscopy analysis platform (General Electric Medical Systems, Milwaukee and a semiautomatic program.32,33 All data were processed by one of us (T.E.), who was blinded to the diagnosis of the subjects. These measurements yielded metabolite concentrations in "institutional units," which were converted into millimoles per kilogram concentrations by means of the published normal values in occipital cortex.33 To compare our data with those previously reported, we also determined metabolite ratios with CR used as an internal standard.
Statistical analyses were performed with Statview (Abacus Inc, Berkeley, Calif). Descriptive analyses were performed on each metabolite. Comparisons between patients with myotonic dystrophy (excluding patient 3) and healthy subjects for each brain metabolite in each brain region were performed by Student t tests. Patient 3 was excluded in the comparison test because of a lack of an appropriate age-matched control. Regression analyses of metabolite concentrations on the trinucleotide repeats, and between different metabolites, were performed by means of a linear regression model. All values in the text and tables are reported as mean±SE; P values less than .05 are considered significant, while P values between .05 and .10 are considered a trend for significance.
The patients with myotonic dystrophy had a duration of illness of 13.8±3.5 years, with a mean age at onset of the illness of 24.1±3.2 years. Twelve of 14 patients had paternal inheritance of the disease. Neither age at onset nor duration of illness correlated with CTG repeats. However, Mini-Mental State Examination scores showed a trend for correlation with CTG repeats (r=0.48; P=.10). In addition, serum creatinine level correlated with age at onset of illness (r=0.69; P=.006) but not with duration of illness or any of the brain metabolites. Table 1 shows some clinical findings of the patients with myotonic dystrophy. Seven patients had cataracts and, except for 1 patient (patient 11), all had percussion or grip myotonia in their hypothenar muscles. All patients had facial diparesis, variable severity of muscle weakness with atrophy in the distal extremities, and hyporeflexia. The electromyogram showed characteristic myotonia in all patients except for patient 3. All of the male patients showed frontal balding except for patient 14. Low estrogen level of 136 pmol/L (normal, 224-1285 pmol/L) was detected in patient 1. Three of the 7 male patients (patients 7, 10, and 12) showed reduced testosterone levels of 7.3 to 8.0 pmol/L (2.1-2.3 ng/mL) (normal, 10.4-34.7 pmol/L [3.0-10.0 ng/mL]). Overnight urine cortisol levels were found to be low in 2 patients (patients 5 and 8), while PM cortisol level was elevated in 2 other patients (patients 4 and 10). Insulin resistance was found in 4 subjects (patients 4, 7, 9, and 12), as reflected by elevated insulin levels of 189 to 458 pmol/L (normal, 29-158 pmol/L) with normal serum glucose levels. No thyroid hormone abnormalities were noted except in patient 7, who was receiving thyroid hormone replacement. Patient 2 gave birth to patient 3, who was a floppy infant at birth.
Magnetic resonance images of all the healthy subjects exhibited no abnormalities, while MR images of only 7 of the patients with myotonic dystrophy exhibited as completely normal. The other 7 patients showed minimal to mild amounts of confluent periventricular white matter lesions (Table 1 and Figure 1). These lesions were located primarily adjacent to the posterior horn of the lateral ventricles and appeared minimally to mildly hyperintense on both the T2-weighted and the inversion-recovery MR images. No significant atrophy, infarcts, or other focal lesions were noted.
Table 2 shows the cerebral metabolite concentrations in patients with myotonic dystrophy and in healthy subjects (Figure 2). N-acetyl compounds (NA) and glutamate/glutamine were normal in both the midoccipital and the temporoparietal cortical brain regions of the patients with myotonic dystrophy. However, NA showed a trend for a negative correlation with duration of illness (r=−0.45; P=.1). Myoinositol (MI) concentration was significantly increased in both cortical regions (19% and 12.9%). The MI level in the temporoparietal brain region also showed a trend for correlation with duration of illness (r=0.37; P=.1). In addition, CR and CHO levels were elevated in both brain regions, but no correlation with duration of illness was observed. To confirm the quantitative values, we also analyzed the data by means of metabolite ratios with CR as the internal reference. We found a lower NA/CR ratio in both brain regions; these lower values resulted from the relatively normal NA and elevated CR levels. The ratios of CHO/CR were relatively normal in both brain regions, since both CHO and CR levels were elevated. However, the MI/CR ratio was higher, although not significantly, in both brain regions, which agrees with the finding that the increase in MI level is greater than the increase in CR level. None of the metabolite ratios (NA/CR, CHO/CR, and MI/CR) in either brain region correlated with age, age at onset, or duration of illness, except for MI/CR in the temporoparietal brain region, which correlated with age at onset (r=0.57; P=.03).
In patient 3, the only patient with the congenital form of myotonic dystrophy, we found mildly elevated CHO and lower NA levels but no elevation of MI or CR level in either brain region when compared with the adult controls. Patients with hormonal abnormalities did not show significantly different metabolite abnormalities compared with those without hormonal alterations.
To further evaluate the relationship between the metabolite abnormalities and the genetic defects, we performed regression analyses of the metabolites on the CTG repeats. We found significant correlations between CTG repeats and CR in both the occipital cortex (r=0.71; P=.009) and the temporoparietal cortex (r=0.76; P=.004; Figure 3). We also found a significant correlation between CTG repeats and MI level in the temporoparietal cortex (r=0.77; P=.004) but not in the occipital cortex (Figure 3). Although CHO level was elevated in the patients with myotonic dystrophy, no significant relationship was found with the number of the CTG repeats. The NA level did not correlate with the number of CTG repeats. The Mini-Mental State Examination score showed a trend for correlation with CTG repeats but no correlation with any of the brain metabolites.
We also observed a relationship between MI and CR levels in the temporoparietal brain region (r=0.77; P=.002) and a trend in the occipital cortex (r=0.49; P=.09) of the patients with myotonic dystrophy. The MI level did not correlate with CHO level in either brain region in these patients.
This study found mild and nonspecific abnormalities on MR imaging and abnormal cerebral metabolite concentrations on 1H MRS in a group of patients with myotonic dystrophy. The MR imaging abnormalities are in agreement with previous reports of patients with myotonic dystrophy,34 except that our patients showed primarily periventricular white matter hyperintensities adjacent to the posterior horns of the lateral ventricles (temporoparietal white matter). This finding is consistent with neuropathological and other neuroimaging reports that the temporoparietal or temporal lobe regions are the most severely affected in myotonic dystrophy.18,25
For the MRS study, the 2 voxel locations, temporoparietal gray matter and midoccipital gray matter, were chosen because previous single photon emission computed tomographic studies showed primarily temporoparietal hypoperfusion in patients with paternally inherited myotonic dystrophy,18 and because neuropathology studies also documented temporal lobe and occipital cortex abnormalities.23- 25 In both the occipital and temporoparietal brain regions, we found increased levels of MI, CR, and CHO and normal NA levels. The NA/CR ratio, however, was significantly lower because of the elevated CR level. Our finding of a decreased NA/CR ratio is consistent with the only previous MRS study in myotonic dystrophy.35 In that study, Hashimoto et al35 examined 5 pediatric patients with congenital myotonic dystrophy and found decreased NA/CHO and NA/CR ratios in various brain regions (occipital, frontal, and parietal regions containing both gray and white matter in each voxel). They concluded that NA level was decreased in their patients, possibly as a result of a developmental disorder of neurons in myotonic dystrophy. There are 2 possible reasons for the different conclusions from their study: (1) The patients studied by Hashimoto et al had congenital myotonic dystrophy, while all of our patients (except for patient 3, who was excluded from the comparison studies) had adult-onset, and primarily paternally inherited, myotonic dystrophy. (2) Hashimoto et al used only metabolite ratios rather than the individual metabolite concentrations; it is also difficult to compare their study with ours since they used a different method than we did, long echo time measurements (TE, 270 milliseconds) vs our short echo time study (TE, 30 milliseconds). However, our measurements demonstrate no significant decreases in NA levels; the decreased NA/CR and NA/CHO ratios primarily result from increased CR and CHO levels. The relatively normal NA level reflects minimal neuronal loss or dysfunction in our patients. We observed a trend for NA to decrease with duration of illness, which indicates possible neuronal loss with the progression of the disease.
Furthermore, levels of CR and MI, but not NA or CHO, positively correlated with the number of trinucleotide repeats. There are several possible explanations for these correlations. First, because MI has been identified as a glial-specific marker,36 elevated MI level suggests increased glial content. In addition, recent studies showed that CTG repeats correlate with clinical disease severity on neurologic examination.37,38 Consequently, the positive correlation of MI level with CTG repeats suggests that an increase in glial content is related to the severity of the disease. Elevated MI level has also been observed in numerous diseases, such as multiple sclerosis,39 dementia associated with human immunodeficiency virus type 1,40,41 progressive multifocal leukoencephalopathy,42 Alzheimer disease,43 and frontotemporal dementia.44 All of these diseases show increased glial activity because of either glial hypertrophy associated with repair processes or gliosis in regions with neuronal loss. Furthermore, MI also is known to be an osmolyte45; its role in the brain may be for the maintenance of cell volume in reactive astrocytes.46
Glial proliferation associated with neuronal degeneration has been shown throughout the cerebral cortex of myotonic dystrophy.23 In some brain regions, such as the hypothalamus and brainstem, marked gliosis was associated with well-preserved neurons.23 Others observed intracytoplasmic inclusion bodies in the thalami26,47 as well as in the cortex, putamen, and caudate; these were thought to be specific for the pathogenesis of myotonic dystrophy, since they were found in much higher numbers than in the controls.47 Recent studies also reported neurofibrillary changes similar to those of Alzheimer disease in the limbic and insular cortical regions in brains of patients with myotonic dystrophy.23 The presence of abnormally phosphorylated τ protein, most prominently in the temporal lobes and different from those found in Alzheimer disease, also has been reported.25 Our findings of metabolite abnormalities in the temporoparietal region are consistent with neuropathological and immunohistochemical observations that the temporal lobes are affected in myotonic dystrophy. However, we find additionally that the midoccipital gray matter regions are abnormal.
The mechanisms underlying the increased CR level and the correlation of CR level with CTG repeats are less clear. There are 2 possibilities for the increased CR peak. First, there might be a relationship between the severity of the trinucleotide repeats and CR uptake into the brain, since CR is synthesized only in the liver. This increased uptake may in turn result from an abnormality in the CR transporter, which is in the same family of sodium- and chloride-dependent transporters for the uptake of choline.48 In nondystrophic myotonic diseases, both chloride and sodium channel defects have been shown in muscle49- 51; whether these abnormalities also occur in myotonic dystrophy is unknown. In parallel with elevated MI level, elevated CR level has been observed in the adjacent white matter of lesions in multiple sclerosis52 or progressive multifocal leukoencephalopathy42 and in the white matter of cocaine users.53 While the pathologic findings in brains of cocaine users have not been well studied, both multiple sclerosis and progressive multifocal leukoencephalopathy are associated with marked gliosis.
A second possibility for the increased CR peak may be increased glial content, as discussed above in association with increased levels of MI. The concomitant increase in CR along with MI levels is supported by a significant correlation of CR and MI (r=0.77; P=.002) in the temporoparietal cortex. The same study that showed MI to be a glial-specific marker also demonstrated that phosphocreatine/adenosine triphosphate is 3 times higher in glial cells than in neurons.36 Another study showed that MRS of cell cultures of astrocytes have 2 times higher CR and 3 times higher taurine concentrations than neurons.54 Because of the proximity of taurine (at 3.08 ppm) to CR (at 3.04 ppm), the elevated CR peak in our study may, in fact, be caused partly by elevated taurine levels. However, whether the elevated CR peak results from actual elevation of CR compounds or of taurine, both explanations support the increase in glial content. Therefore, increase in glial cells would elevate the total brain CR or taurine level, while a concomitant decrease in neuronal cells, and hence a decrease in NA and CR compounds, would lower the effect of the elevated CR level. However, because our patients with myotonic dystrophy had only minimal decreases in NA level, the changes in CR concentration appear to be related primarily to the increased glial content.
The increased CHO level observed in gray matter of the patients with myotonic dystrophy also supports possible increased glial content. Urenjak et al54 showed in their cell culture studies that astrocytes and oligodendrocytes both have 2 to 3 times higher CHO levels than do neurons. In addition, elevated CHO level may be seen in conditions with cell membrane abnormalities or white matter diseases, such as multiple sclerosis, progressive multifocal leukoencephalopathy, and human immunodeficiency virus.41,42,52,55 All of these diseases are associated with demyelination, gliosis, and increased oligodendrocyte activities in association with the repair processes. Our patients with myotonic dystrophy showed minimal to mild periventricular white matter hyperintensities. Although we did not examine the white matter directly in our localized MRS, we would expect an even higher elevation of CHO levels in these brain regions. Future MRS studies of myotonic dystrophy should include these white matter brain regions. Finally, patients with myotonic dystrophy show marked somatic mosaicism of the CTG repeat length56; therefore, the lack of correlations between CHO levels and CTG repeats from the blood cells might not reflect the actual contribution of CTG repeats to CHO metabolism in the brain tissue.
In summary, we found significant abnormalities of cerebral metabolites with 1H MRS in patients with myotonic dystrophy. The abnormalities were more pronounced in the midoccipital gray matter than in the temporoparietal region. The most significant abnormalities were increased concentrations of MI and CR, which were associated with the longer CTG repeats. We attribute these abnormalities to increased glial content in the 2 brain regions studied. This study shows that 1H MRS is a powerful tool to evaluate brain biochemistry, which may reflect the extent of the pathological involvement in the brains of patients with myotonic dystrophy. Future studies correlating MRS, CTG repeats, and neuropathological findings will be necessary to confirm these relationships.
Accepted for publication October 3, 1997.
This study was supported in part by General Clinical Research Center grant MO1 RR00425 and Scientist Development Award for Clinicians DA 00280 from the National Institutes of Health, Bethesda, Md.
We thank the Harbor-UCLA Imaging Center/Insight, Inc, Torrance, Calif; and Athena Neurosciences Inc, Worcester, Mass (Michael Boss, PhD, for the contribution of the CTG testing in those patients with myotonic dystrophy) for their support.
Reprints: Linda Chang, MD, Department of Neurology, Harbor-UCLA Medical Center, 1000 W Carson St, Building B-4, Torrance, CA 90509 (e-mail: firstname.lastname@example.com).


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Staybridge Suites San Antonio Downtown Conv Ctr
All the comforts of home with useful, money saving amenities in the location ideal for convention attendees, tourists or business travelers. Each spacious studio, 1 or 2 bedroom suite includes a full kitchen, living area, desk and bedroom. Spread out and "get comfortable" for an enjoyable night or extended stay.
Enjoy our daily breakfast buffet, light dinner and drinks at our Evening Social on Monday, Tuesday and Wednesday. Stay connected with free Wi-Fi and 24-hour business center. With the outdoor pool, patio, grills, 24-hour self-service laundry facility and fitness center some guests think staying at Staybridge Suites is even better than home.
Guests like the short 3 block walk to the Gonzalez Convention Center, RiverWalk, and Alamo. Our location is perfect for business travelers wanting a short, hassle-free commute to Geekdom, Brooks City Base, Port San Antonio, Kelly Field as well as Ft Sam Houston and Lackland. Families coming to San Antonio will appreciate our location too if visiting Sea World, Six Flags Fiesta Texas or the San Antonio Zoo too!
As the closest hotel to the Alamodome, guests will appreciate the short walk across the hotel's parking lot to the Alamodome for special events including this summer CONCACAF and UTSA's home football games. Coming into town for a concert or show at The AT&T Center and Freeman Colisium...both are just 2.5 miles away!!
Bring your furry friends to our pet friendly hotel downtown too!
Quick Info
- Check In: 4:00 PM
- Check Out: 12:00 PM
- Minimum Check-In Age: 21
- Late Check Out Available
- Self Parking Fee: 18 USD
- Print Fact sheet
- Chat Online
- Important Update
Hotel Highlights
- On-site Guest Self-Laundry Facilities
- Housekeeping Full Service
- Complimentary Breakfast Buffet
- Standard Wireless Internet service is free for all members
- On-Site Fitness Center Available
Guest Reviews
Overall Experience
Hotel stay
July 22, 2017
It was great. I would recommend to other people. The view and room were nice.
Comfortable STAY and very CONVENIENT
July 20, 2017
My family and I traveled on leisure 07/03-07/05.
The room was absolutely beautiful and had everything a kitchenette would have. The room was huge and very spacious.
The breakfast had good selections and very contemporary...
Very good distance from the hotel to the Riverwalk and other places..... loved your little gym/pool area.
The only thing though, is that the staffs weren't as greetful and didn't smile much..... other then that..... we ABSOLUTELY enjoyed our stay and loved it.... Definitely looking forward to staying there again when we visit San Antonio!!!!!!
Room overall was better than expecting.
July 20, 2017
Great room...quiet and comfortable. Breakfast options were good and serving times were convenient.
Close, quiet, great service
July 17, 2017
We stayed here for our honeymoon in one of the kitchenette suites. The hotel was just on the other side of the highway from downtown,there was a walking path under the highway to downtown. The train station was next door and the mall was on the other side of the overpass. Despite being so close to downtown and next to the highway it was quiet and not congested. The room was spit-spot and had everything we could have possibly needed for a longer stay. The view from our room was incredible. We could see right down the street of Downtown San Antonio, the Mall, the Tower of the Americas and more. The only very slight downside was that the parking was in a small lot across the street, but in a city where space is limited it was understandable. LOVED this hotel! Wish we could have stayed longer!


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Fuji Chobo-no-yu Yurari is the famous Onsen where you can enjoy views of Mt Fuji while soaking in a hot Japanese bath. Fuji Chobo-no-yu Yurari is near Kawaguchiko.
Mount Fuji 5th Station (Kawaguchiko) is the 5th point on the walk up Mount Fuji from the Kawaguchiko side. Mount Fuji 5th Station (Kawaguchiko) is at 2,300m and is as far as normal cars and tour buses can go up the mountain. There is an observatory point, which on a clear day, allows you to look down to Komitake Shrine and Lake Yamanaka. From Mount Fuji 5th Station (Kawaguchiko) there are several hiking tracks: Ochudo which encircles Mount Fuji staying at roughly the same altitude. Ochudo track leads to the lookout point Oniwa, where there are some spectacular views. Continuing further long Ochudo track leads to the lookout point Satomidaira, where a full view of Kawaguchiko and Lake Yamanaka can be obtained.
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2 Reviews on "Mount Fuji 5th Station (Kawaguchiko)"
Valerie Mount Fuji 5th Station (Kawaguchiko)
I arrived at the 5th station for my first climb up the mountain around 8:00 PM. It was dark, cold, and the stores were all closed (minus the souvenir store that had an unclean bathroom you need to pay to enter). There's no illumination at night either, so be careful of where you are stepping when heading to the mountain trail–as there's horse stalls nearby. During the day, the station's so packed you'll have a hard time finding some place to sit.
Craig Fryer Post authorMount Fuji 5th Station (Kawaguchiko)
May on a clear day there might be better views from Mount Fuji 5th Station, but you don't really obtain a very good view of Mount Fuji while half way up it. You need to Mount Fuji from some distance to see it with great perspective. There are some interesting sites around the Mount Fuji 5th Station.
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Tenjo-Yama Park Mt Kachi Kachi Ropeway
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Anubis is an ancient Egyptian god of the dead who would greet them as they arrived in the underworld. He was the caretaker of the cemeteries and the subject of prayers at Egyptian funerals. His black head resembled a jackal, while his body was human. Making an Anubis mask can be a hands-on learning tool for children studying the gods of ancient Egypt or a cool, original way to show up at a costume party.
Things You'll Need
- Cardboard
- Pencil
- Scissors
- 1 cup flour
- 1 cup water
- Mixing bowl
- Spoon
- Newspaper
- Acrylic craft paint
- Paint brush
- Compass
- Elastic
Measure the wearer's forehead with a tape measure from temple to temple. Draw the shape of a jackal head onto a piece of cardboard using the measurement of the forehead and taper it down to a narrow snout.
Use scissors to cut out the shape of the head. Hold it up to the wearer's face and make pencil marks where the eyes go. Then cut out holes for the eyes.
Draw the outline of two pointed ears, cut them out and use craft glue to attach them to the back of the head shape.
Make a paper-mache glue by mixing 1 cup flour with 1 cup water. Mix until it's well-blended.
Cut a newspaper into strips approximately 1 inch wide. Dip the strips into the paper-mache glue and begin to cover the cardboard head and ears. Cover both the front and back with the paper strips. Aim for at least three layers of the paper. Allow it to dry overnight.
Paint the entire mask black using acrylic craft paint. Once the black paint dries, use grey or white paint to add facial details. Create a small slit for the mouth toward the bottom of the snout and two dots for the nostrils about a 1/2-inch above.
Use a compass or similar sharp instrument to puncture holes at the midpoint of the mask on either side. Thread a piece of elastic through each hole and knot it to secure.
Tips & Warnings
- You can spray paint the mask black to save the time of hand painting it.
- Wear the mask with a black apron-like skirt, no shirt, sandals and bracelets around your arms and ankles. Hold a large shepherd's crook.
Related Searches
- Photo Credit Hemera Technologies/AbleStock.com/Getty Images
You May Also Like
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What is AIESEC?
What do we envision?
What is our impact?
How do we do it?
What are the AIESEC values?
AIESEC values
The AIESEC Way
is not only a description of the way (manner) we aim to make a positive impact on society, but also describes the way (road) we are taking to achieve what we envision.
What we envision
The way we do it
Our impact
What is AIESEC?
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Padres beat Mariners on disputed runJul 3, 2011 - 5:35 AM
With one out in the fifth, Maybin was awarded first base after the count went to 3-2. But nobody caught home plate umpire Phil Cuzzi's mistake at the time when Maybin flipped the bat and trotted to first base. The scoreboard showed a three-ball count before Doug Fister delivered the high pitch that led to Maybin's phantom walk.
Maybin then moved to second on Anthony Rizzo's groundout and crossed the plate on Gonzalez's base hit when the ball caromed off the glove of shortstop Brendan Ryan and into left field.
"I thought I just missed a pitch," Mariners manager Eric Wedge said. "Nobody reacted to it, nobody did anything and he went to first base. I felt like I was in the wrong, but obviously that wasn't the case. It was just the third ball and that was pointed out to me after the fact."
That was not the only bad luck Seattle had. Fister (3-9) tossed his third complete game of the season, allowing the crazy run on six hits to take the hard-luck loss. He also struck out seven and walked one.
Padres starter Cory Luebke (2-2) pitched six scoreless innings. He gave up just two hits and struck out seven.
"He threw the ball well," Padres manager Bud Black said of Luebke. "What I liked was that he was really aggressive with the fastball. I thought that he pitched really well with a good live fastball to both sides of the plate."
The Mariners' best chance to score early on came in the second. Greg Halman hit a one-out double. Luebke retired the next two batters to keep Seattle off the board.
The Padres scored the lone run of the game in the fifth. Maybin actually fell behind 0-2 in his at-bat before fouling off a pitch. Fister then threw a ball and Maybin fouled off another pitch. Maybin then watched a ball go by him in the dirt, but the count on the scoreboard showed 3-2 instead of 2-2, where it should have been. The next pitch was high and Maybin went to first base without a protest from anyone. Maybin later scored on Gonzalez's two-out base hit.
"You have to do it before the next pitch is thrown," Wedge said of a possible protest. "You have to go out there and do something. That's something that's never happened before. I think that's what makes it so unusual when you're having conversations, watching the game, working the ball game...there was no reaction there from anybody. I just felt like I must have missed one."
Seattle stranded a runner on third in the seventh. With Chad Qualls pitching, Ryan reached first on Jason Bartlett's fielding error. Ryan stole second and moved to third on a Franklin Gutierrez fly out. But Qualls retired the next two batters to keep the Padres in front.
Mike Adams tossed a perfect eighth and Heath Bell pitched the ninth for his 24th save of the season. That wrapped up San Diego's eighth win in 10 games.
Game Notes
Seattle has still won four of five from San Diego this season...Fister has allowed just three total runs over his last three starts...Padres second baseman Orlando Hudson (bruised left shin) missed the game...The Mariners were without catcher Miguel Olivo (hamstring) and second baseman Dustin Ackley (bruised ribs)...Mariners pitcher Blake Beavan will make his MLB debut on Sunday...This was the 500th career appearance for Qualls.
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- Alberto Gonzalez singled to left scored Cameron Maybin. Runner on first with two outs and Will Venable due up.
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- Padres under fire for mishandling gay chorus' anthem May 22
- Plate umpire Rackley leaves after getting hit by foul bunt May 22
- Martin, Cano help Mariners sweep, hand Reds 7th loss in row May 22
- Mariners place Marte on 15-day DL, recall Taylor May 22
- Solarte draws bases-loaded BB in 11th, Padres walk off again May 22
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- Dodgers-Padres Preview May 22


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If you are looking for Genworth life insurance reviews then you have come to the right place. Genworth Life is one of dozens of life insurance companies that TermLife2Go represents. In the following review we will cover the positives, negatives and alternatives to Genworth Life Insurance Company.
Feb 4, 2016: According to Bloomberg.com, Genworth Financial has stopped sales of traditional life insurance products so the company can focus on stabilizing the unit that provides long-term care coverage.
October 23, 2016 update: China Oceanwide Holdings Group Co. agreed to buy Genworth Financial Inc. for $2.7 billion in cash, pledging to help the U.S. firm manage its debt and strengthen life insurance units after it was hurt by higher-than-expected losses tied to long-term care coverage. Source.
2017 Genworth Life Insurance Reviews
The Positives
Genworth is one of our favorite companies and made our 2016 top ten best life insurance companies list for the niches the company fills.Unfortunately, the Company is not currently accepting new individual life business. We are currently in stand-by mode until more information is made available.
About Genworth
From the company's website: Genworth Financial, Inc. is a Fortune 500® company with roots tracing back to 1871. We have more than $100 billion in assets and a presence in more than 25 countries.
For those seeking First Colony Life Insurance Company, the company merged with Genworth in 2007.
Review of Genworth Life Insurance Company
Genworth Life Insurance A.M. Best Company Rating
As you may have read in other Genworth Life Insurance Company reviews, as of January 28, 2016, the company is rated "A", excellent, by A.M. Best Company, the premier rating agency for life insurance companies. This means that the company's financial strength is excellent. There is no need to lose any sleep if Genworth Life is your life insurance company.
Favorable Underwriting for "large build" clients
Genworth Life Insurance has one of the most liberal underwriting build charts in the marketplace. Often a client will be outside of the build requirements with every other company and still meet the requirements with Genworth Life. For our bigger boned clients, Genworth Life gets the job done as one of the most affordable life insurance companies for clients with large builds.
For example, a 5'10" male or female up to 209 lbs can still qualify for a preferred plus rate class. And a male or female over 65 will have an even more liberal build chart to work with. With virtually every other carrier out there these same clients will qualify for a preferred rate class, at best. And the difference in premium between a preferred plus rate class and preferred can be as high as 15%. That means Genworth Life's more liberal build chart can save clients thousands of dollars over the life of their policy.
More Genworth Life Insurance Niches
Genworth Life is among the industry leaders when it comes to the company's liberal underwriting for sleep apnea patients. Add that with the above mentioned large build chart, and you have a company that is a excellent choice for sleep apnea life insurance.
Genworth Life is also among the industry leaders for protecting those with ulcerative colitis, asthma and arthritis.
Genworth Life Insurance applications are great for people who travel to foreign locals or are planning on traveling in the near future.
Genworth Life will consider a preferred best rate class for blood pressure readings of 140/85 under 61 or 150/90 for clients 61 and older as long as no history of treatment or medication.
Genworth Life Insurance Company's Deep Product Line
Genworth Life Insurance Company has a product for everyone. The company offers term and whole life insurance, universal life insurance, annuities, and on and on.
Genworth Colony Term Life Insurance: Term life insurance lasts for a period of time (10, 15, 20, and 30 years). Consider term for the following: to protect the household's primary bread winner, to secure SBA loans, or for divorce life insurance.
Genworth Life's permanent life insurance portfolio includes whole life, Indexed Universal Life and Guaranteed Universal Life. Permanent life insurance is generally recommended for long term planning such as funding a buy sell agreement, estate planning, or key person business insurance.
Sample Genworth Life Insurance Quotes
Genworth is currently not offering individual life insurance plans. The Company has not announced when or if it will resume this line of business.
Where Genworth Life Insurance Comes Up Short
Genworth Life comes up short on providing a competitive no exam life insurance option. Often, choosing a no medical exam policy can be a great way to secure coverage and avoid the reality that your health is not as good as you suspected.
Exam versus No Exam: We will often recommend that our clients lock into no physical exam life insurance before applying for fully underwritten coverage. The thought process goes like this: if you have not had a medical check-up in the last few years, why take the risk? Instead, you can lock into a no exam policy today and secure protection. Once your policy is in force, you can then either get a physical or take a medical exam for life insurance. However, since you already locked into coverage you do not have to fret if something pops up on your exam. From there, you either keep the no exam policy or go with the new policy once you are approved.
Genworth Life is not the only fish in the sea
Whereas Genworth Life Insurance is great when it comes to the company's build requirements, the company comes up short in other areas.
On the flip side of the company's niche areas are the areas where Genworth Life does not shine. For example, if any parent has had a history of coronary artery disease or cancer before the age of 60 then Genworth will not consider the client for the top rate class.
And Genworth Life's underwriting requirements are not as liberal as other carriers when it comes to certain medical conditions. If you are in the market for diabetic life insurance or if you have a poor driving record, you might be better served applying with a different life insurance company that caters to your specific health or lifestyle profile.
In fact, getting the cheapest life insurance out there comes down to this one main point: you need alternatives.
Alternatives to Genworth Life Insurance
Consumers seeking Genworth life insurance reviews typically are searching the internet to uncover all their choices. Since no one life insurance company is right for everyone, having alternatives is crucial. The key to finding the best life insurance policies available is to know where to look. That is where TermLife2Go comes in.
About TermLife2Go
TermLife2go is an agency that works with dozens of top rated life insurance companies. Our #1 priority is to find you the best company at the best price…for you! We tailor a policy specifically to you because no two clients are alike. Let us leverage our expertise for you and see if we can't save you thousands of dollars on life insurance.
For a free life insurance consultation and for free quotes from Genworth Life and dozens of other life insurance companies, please call us to see what we can do for you!
If you enjoyed our article, Genworth Life Insurance Reviews, and/or have additional questions, please leave a comment below.


text: Ingredients Edit Whiskey Lilt Directions Edit Pour a shot of whiskey into a glass, and top up with lilt. Simple. Retrieved from "http://cocktails.wikia.com/wiki/Liltspeed_Champion?oldid=15420" Ad blocker interference detected! Wikia is a free-to-use site that makes money from advertising. We have a modified experience for viewers using ad blockers Wikia is not accessible if you've made further modifications. Remove the custom ad blocker rule(s) and the page will load as expected. Categories: Whiskey recipes Lemon-lime soda recipes Add category Cancel Save