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Football rumours from the media
Aleksandar Kolarov is on the brink of leaving Manchester City to join Roma, manager Pep Guardiola has confirmed.
When Pep Guardiola arrived at Manchester City last summer there was a feeling the club had found the final piece of the jigsaw.
The first ever Manchester derby on foreign soil went United's way as Romelu Lukaku and Marcus Rashford put City to the sword in Houston.
:: Arsenal topped the charts in terms of playing time for homegrown players, with Hector Bellerin, Francis Coquelin, Alex Iwobi, Kieran Gibbs,...
Former Manchester United winger Ryan Giggs expects his old club to continue their tradition of promoting youth and is hopeful another 'Class of 92' can emerge at Old Trafford.
Arsenal leaned more heavily on their academy than any other Premier League club last season, a Press Association Sport study has found.
Monaco are threatening to report "important" European clubs to FIFA for making contact with star striker Kylian Mbappe without the club's consent.
Greg Stewart and Gary Mackay-Steven scored their first goals for Aberdeen as the Scottish side beat Siroki Brijeg 2-0 to reach the third qualifying...
A struggling Rory McIlroy admits he needed a kick up the backside from caddie JP Fitzgerald to get his Open back on track after it looked like he was crashing halfway through his first round.
Alvaro Morata has described Chelsea as "the best club" and Antonio Conte as "one of the world's best coaches" after his arrival in London ahead of his transfer from Real Madrid.
West Ham have agreed a deal with Bayer Leverkusen to sign Mexico striker Javier Hernandez.
Royal Birkdale warmly welcomed back one of its former Open champions but Padraig Harrington was disappointed not to have given the crowds more...
Joseph O'Brien reported his sister Ana in "great form" on Thursday after the fall at Killarney earlier this week that left her with multiple fractures.
Aston Villa have signed Stoke midfielder Glenn Whelan in a deal which could rise to £2million.
Brighton have made their fifth summer signing, bringing in Mathias Normann for an undisclosed fee from Norwegian second division side FK Bodo/Glimt.
Northern Ireland international Corry Evans hopes his injury nightmares are behind him as he looks to prove his fitness to Michael O'Neill before...
Brendan Rodgers believes Celtic will again have to take the initiative when Rosenborg travel to Parkhead next week for the first leg of their...
Two-time major winner Jordan Spieth gave himself nine out of 10 after beginning his bid to secure the third leg of a career grand slam in impressive fashion in the 146th Open Championship.
Manchester City still want to make as many as four more summer signings, with Pep Guardiola confirming an interest in Real Madrid right-back...
Jose Mourinho has downplayed the first-ever Manchester derby on foreign soil as a "competitive training session" as United prepare to face City in Houston.
Alvaro Morata is bound for Chelsea rather than Manchester United but Jose Mourinho does not care having wrapped up a deal for "amazing" striker...
:: Manchester United academy graduates played a total of 44,055 Premier League minutes in the 2016-17 season, more than double the number of minutes for any other academy.
Manchester United's academy made the single biggest contribution to last season's Premier League of any youth set-up, a Press Association Sport study has found.
Ryan Giggs believes Manchester United's reputation for giving kids a chance has helped the club's academy become the biggest producer of...
Dundalk bowed out of the Champions League at the second qualifying round stage following a 2-1 defeat to Rosenborg after extra-time in Trondheim.
Chelsea have agreed terms with Real Madrid for the transfer of Spanish international striker Alvaro Morata, the Premier League club have announced.
Everton have been dealt a double injury blow after Ross Barkley and Ramiro Funes Mori underwent surgery, with the latter expected to miss a...
Pep Guardiola still wants to make as many as four more summer signings, with the Manchester City manager confirming interest in Real Madrid right-...
Southampton goalkeeper Fraser Forster has signed a new five-year contract with the club.
Bournemouth goalkeeper Asmir Begovic felt Antonio Conte was just what Chelsea needed - but named Jose Mourinho as the best manager he worked under at Stamford Bridge.
Jesse Lingard is determined to confound the doubters and repay Manchester United's faith, especially as he feared his Old Trafford dream might have been over a few years ago.
Former Sao Paulo assistant Michael Beale believes the scarcity of English managers in the Premier League and a lack of a second language is...
Newcastle have announced the signing of winger Jacob Murphy from Norwich for an undisclosed fee.
Rory McIlroy admits it is hard to argue with being rated a 20/1 chance to win the Open Championship, but believes he can defy the odds...
Sam Allardyce would consider a return to football management if the right international job came up, but intends to enjoy his break from the game first.
Leeds have announced the signing of defender Matthew Pennington on a season-long loan from Everton.
RB Leipzig owner Dietrich Mateschitz has revealed his club have turned down a 75 million euro (£66million) offer for Liverpool target Naby Keita.
Leicester have completed the signing of goalkeeper Eldin Jakupovic from Hull.
Liverpool midfielder Kevin Stewart has flown home from the club's pre-season trip to Hong Kong to complete a move to Hull.
Jose Mourinho intends to bring stability to Manchester United and wants to remain in charge for the next 15 years.
Arsene Wenger has told Alexis Sanchez to fire Arsenal back into the Champions League after insisting the Chile international will not be sold...
Chelsea boss Antonio Conte challenged everyone at Stamford Bridge to "work even harder" as the Italian plots more success next season having signed a new two-year contract on improved terms.
Ireland's Jason Smyth claimed his second victory of the World Para Athletics Championships on Tuesday night and is determined to continue his global domination.
Second choice? Second place? Not for Antonio Conte. He hit the ground running at Chelsea and delivered.
Manager Antonio Conte has signed a new two-year contract with Chelsea.
Linfield manager David Healy expressed his dismay at the "few idiots" who took the shine off his side's gutsy performance against Celtic in Belfast on...
Arsenal will not sell Alexis Sanchez this summer, according to manager Arsene Wenger.
Brazil international Lucas Leiva has completed his transfer from Liverpool to Italian club Lazio.
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Published: August 21, 2013 - 06:05 AM | Updated: August 21, 2013 - 10:59 PM
The printing presses at the Beacon Journal started rolling at midnight Tuesday, right on time.
The press run took until almost 7 a.m. to complete, more than four hours late.
In between, we had problems.
The presses broke down multiple times early Wednesday morning. As a result, delivery of the Wednesday Beacon Journal was delayed.
According to Vicki Kuhns, printing production manager, here is what happened:
• The presses started on time at midnight.
• There were a series of mechanical breakdowns, starting just before 1 a.m.
• Those problems continued until 3 a.m., when a decision was made to use backup printing presses.
• At 4:25 a.m., a backup press was ready to roll.
• The backup press did not start smoothly.
• The last papers were printed at 6:47 a.m.
The papers are normally printed by 3 a.m. at the Beacon Journal.
Because the papers were so late being printed, not all of the Beacon Journals could be delivered Wednesday.
"We made every effort to get papers to people on Wednesday," said Jim DeLuca, vice president for circulation. "Unfortunately, we will not be able to deliver some papers until Thursday morning.
"The carriers did the best they could," DeLuca added. "But unfortunately this situation was beyond the control of the carriers."
Readers started calling the Beacon Journal once they realized they did not have the paper. So many people called, the newspaper's phone system was overwhelmed. That resulted in busy signals, which many readers found frustrating.
Most wanted to know where their Beacon Journal was. (One reader wanted to know the movie times so she could see a matinee Wednesday afternoon.)
In an effort to communicate the problem, a story about the problem was posted on the Beacon Journal's website, Ohio.com. Editors also contacted other media regarding the story.
The Beacon Journal made its replica edition of the paper available for free on Ohio.com Wednesday.
The mechanical problems with the presses are being addressed. Normal delivery times are anticipated for today.


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Diomed was the Œtolian sun-god; Achilles was worshipped in Thessaly long before he became the hero of the tale of Troy.
The representation is one of the sun-god Dionysos upon a cross.
Apollo is in his grotto, served by seven graceful nymphs: while close by the steeds of the sun-god are being watered by tritons.
But the sun-god holds his eyes shut and does not let him get away.
Yet the fragments do present us with an invocation to the sun-god, though weakened, it is true, and adapted to the new faith.
He is said to be the sun-god of spring, to whom the heat of summer is fatal, and who dies in June.
Here dwelt a beautiful enchantress called Circe, daughter of the sun-god and the sea-nymph Perse.
To him she must come, this rose who could own no lesser god than the sun-god himself.
If I answer not to the voices that call me, my name will be a byword wherever the rays of the sun-god fall.
The hierophant of the sun-god made an effort to climb back on his pedestal.


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Their next challenge will be away to Granada, where they will re-encounter Nolito.The Blaugrana have turned themselves into arguably Europe's best club team in the modern era. Having to watch Real Madrid lift the La Liga title last season looks to have been just a bump in the road for Barcelona.Tito Vilanova's side has a commanding 12 point lead over second placed Atletico Madrid, while Real Madrid is a shocking 16 points back, in third place. Having that cushion domestically, can and should allow Barcelona to rotate their squad, especially ahead of a Champions League match in the coming week.
Granada will play host to Messi, Iniesta and co. but, they showed in their previous fixture at the Nou Camp that they will not lay down and hand Barcelona a victory.It took Barcelona 87 minutes to finally break through against Granada in September, with Xavi getting the goal. A stoppage time own goal from Borja Gomez gave Barcelona the two goal lead, guaranteeing them the full three points.Xavi's absence led to Iniesta having to fill a deeper role in their previous match, and the Spanish midfielder will have to do the same against Granada as Xavi will not be available. Some say Iniesta is Barcelona's best player, so he will get another chance to show that even without his midfielder partner, he still can make it happen for Barcelona.
Spanish forward David Villa will also be missing in action after having been in and out of the hospital with Kidney stones.Barcelona's opposition is 14th on 26 points from 23 matches. They did not start off the season very well, but Luis Lucas Alcaraz has helped the Andalusians make their way back up the table. They are now six points clear of the relegation zone, and recently beat Real Madrid 1-0. One of Granada's newest signings, Nolito, will get a chance to take on his former club. The Spanish player is on loan from Portuguese side Benfica, and he does not seem bothered at the fact that he will take on some of his former teammates."It is complicated, but we will try to be ourselves. If we can beat Deportivo, Real Madrid and Barcelona, then it would be a few days worth celebrating," Nolito told reporters."We know it will be a difficult game, but we are preparing with the same intensity that we had against Deportivo and Real Madrid.
Granada vs FC Barcelona
Spain La Liga League 2013
Date: 17 February 2013 | 17-02-2013
Time: 21:00
Venue: Estadio Los Cármenes, Granada
Granada 1 : 2 Barcelona
Final Score
Previous Matches
- 09-22-12 Barcelona 2-0 Granada
- 03-20-12 Barcelona 5-3 Granada
- 10-25-11 Granada 0-1 Barcelona
With their mind already at San Siro, Barcelona will drop points on the road for the third consecutive match, conceding early and grabbing a late equalizer through the inevitable Lionel Messi.Granada brought in a significant amount of players during the January transfer window, giving them a lot of different options. Nolito and Malaga's Buonanotte are likely the most notable names, but Granada still has El-Arabi and Siqueira who have scored 36% of their goals this season.Going up against a Barcelona side that will certainly have one eye on their Champions League match with AC Milan, Granada could have a chance to pull off an upset, just as they did at home against Real Madrid.With three victories in their last four in La Liga, the Andalusians have also managed four clean-sheets in their last five at home.Keeping Barcelona off the score card will not be easy, but Vilanova's side has not been all that great away from home as of late. Barcelona has won just one of their last four matches away from home, so they will want to grab the full three points on Saturday, although it will not be easy.
The last three meetings between these two sides ended in victory for Barcelona, but their one meeting away to Granada was by the minimum margin. They also took a significant amount of time to break down Granada at home in their match earlier this season.With a number of players getting some rest ahead of their Champions League match, and the fact that they have such a comfortable cushion in the La Liga standings, Barcelona could get complacent on Saturday. Granada will be full of confidence coming off their latest results and they will know that Barcelona could be there for the taking.
- Granada 1-1 Barcelona
As a La Masia youth product and former Barcelona player, Nolito might be especially pumped up for this match to prove a point to his boyhood club. He has been one of the best Granada players and his pace might be key to unlocking Barcelona's defense.
Regardless of who Roura selects to start, Barcelona's philosophy and identity will remain the same as always, looking to overwhelm Granada with quick, intricate passing from the very first minute.
TV Channels Broadcasting List:
- Spain: GOL T, Canal+ Liga
UK: SKY Sports 1, SKY Go
USA: Bein SPORT
South Africa: Supersport
Netherlands: Sport1
Germany: LAOLA1.TV
Brazil: ESPN
India: ESPN (Not Confirmed)
Egypt: Al Jazeera Sports
UAE: Al Jazeera Sports
Granada vs Barcelona match teams squads players probables list information full details here.
- Barcelona Probable Lineup (4-3-3): Valdés(GK); Correia, Piqué, Mascherano, Montoya; Song, Alcantara, Fabregas; Pedro, Sanchez, Messi
- Granada Probable Lineup (4-2-3-1): Toño(GK); Nyom, Lopez, Mainz, Siqueira; Recio, Rico; Torje, Aranda, Nolito; Ighalo


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Islay Tour 2017
Nov 5th - Nov 11th
Montgomery Distillery will be hosting another tour to Islay and Jura on November 5th - November 11th.
The tour will be led by Montgomery distiller Kira Bassingthwaighte, who will guide tastings and introduce guests to the many attractions Islay has to offer, including nature walks, migratory bird watching, the Islay Woolen Mill, and historical points of interest.
The cost of the tour is $3,000 per person (double occupancy) and $3,600 per person (single occupancy).


text:
|Publication number
|Publication type
|Application number
|Publication date
|Jun 30, 1987
|Filing date
|May 13, 1986
|Priority date
|Sep 21, 1984
|Fee status
|Also published as
|Publication number
|Ronald K. Yamamoto, Sophia Pesotchinsky
|Original Assignee
|Vitaphore Corporation
|Export Citation
|BiBTeX, EndNote, RefMan
|Patent Citations (19), Non-Patent Citations (2), Referenced by (158), Classifications (13), Legal Events (4)
|External Links: USPTO, USPTO Assignment, Espacenet
This application is a continuation-in-part of U.S. patent application Ser. No. 653,442 filed on Sept. 21, 1984, now abandoned.
This invention relates to a device for the improved management of microbial invasion associated with percutaneous conduits, and more particularly to a design which allows the device to be used in conjunction with an existing conduit and positioned along the length of the conduit to a desire anatomical site for optimal effectiveness.
A percutaneous device or conduit is an implement which passes through the skin, allowing the linkage of an intracorporeal organ or cavity with extracorporeal equipment. There exists a wide variety of clinical applications for percutaneous devices. In the facilitation of fluid transport, percutaneous conduits called catheters are used to access blood for dialysis, pressure monitoring, or laboratory diagnosis, to deliver drugs or nutritional solutions, and to drain wound exudate. Percutaneous electrical leads are used to allow the monitoring of biopotentials from natural organs or implanted instrumentation, as well as for stimulation of such organs. Percutaneous orthopedic fixation pins are used to immobilize severely damaged bone by mechanical coupling to a rigid external frame.
Despite the widespread clinical need and usage of percutaneous conduits, the presence of the conduit eventually results in baceterial infection, compromising the health of the patient and forcing conduit removal.
FIG. 1 depicts the anatomical relationships referred to in the followinig description of the infection mechanism associated with percutaneous conduits. a conduit 1 spans the various layers of the skin 2. The portion of the conduit which lies outside the body is referred to as extracorporeal, while that within the body is intracorporeal. Conduit 1 is implanted through a wound 3 in the skin, the wound having been made either expressly for the purpose of inserting the conduit or as a result of an injury. In either case, a sinus tract 4 is formed by ingrowth of epithelium into the wound. A good review of the biology and failure mechanisms associated with percutaneous devices can be found in CRC Critical Reviews in Bioengineering, Vol. 5, pp. 37-77, 1981, by A. F. von Recum and J. B. Park.
Bacteria that have penetrated beneath the epitheliumconduit interface into underlying tissues find a favorable environment for colonization. The tissues contacting implanted foreign bodies are in a state of chronic inflammation, impairing the normal defense mechanisms against bacterial infection, a basis for the commonly accepted fact that wounds containing foreign bodies are more susceptible to infection (Willliams and Road, Implants in Surgery, 241-244, W. B. Saunders Co., Ltd. 1973). A classic study demonstrated that while 7.5�106 viable staph aureus organisms were necessary to produce a skin infection, only 3�102 organisms produced an infection in the presence of a silk stitch inserted in the wound (Elek and Conen, British Journal of Experimental Pathology, 38:573, 1957). A more recent study has indicated the phagocytosis of bacteria by leukocytes, the secondary defense against bacterial invasion, is impaired in the presence of some foreign materials, at least in vitro (Borges, L. F., Neurosurgery, 10:55-60, 1982). Once established, bacterial infections around implanted foreign materials usually cannot be managed even with massive antibiotic therapy, forcing removal of the implant.
The advance of bacterial colonization along the conduit surface and interfacing tissues may also result in peritonitis when the peritoneal cavity is penetrated by the conduit. Similarly, joint capsule infection may occur when a wound is drained after orthopedic surgery, and septicemia may result when the vascular system is accessed by an intravenous or arterial line. The constant bacterial challenge and threat of infection created by percutaneous conduits forces conduit removal and replacement in alternate areas when possible, and either discontinuation of the function of the conduit or increased risk of infection when not possible.
The bacterial organisims which initiate infections associated with percutaneous conduits are part of the normal flora on the skin, ranging in density from 10 to 106 organisms per square centimeter. Normally these organisms are unable to colonize into deeper tissues and proliferate, as they cannot penetrate the primary barrier against infection, the epidermal layer of the skin. The presence of a percutaneous conduit requires disruption of this barrier, through which bacteria can invade deeper tissues.
The perimeter at the conduit interface does not seal, even after sufficient time for wound healing. The new healing epithelium, upon reaching the conduit, does not recognize and adhere to the foreign body, but instead grows down along the conduit in an effort to externalize the foreign body, forming a sinus tract 4 which is a pathway for bacterial invasion. A recent clinical study has indicated significant association of bacterial colonization of percutaneous catheters and the density of bacteria present on the skin at the exit site, as one would expect from the infection pathway (Bjornson, et al., Surgery, Vol. 92, No. 4, pp. 720-726, 1982).
The lack of a seal of the conduit to the dermal and epidermal tissues not only allows access for bacteria, but also prevents mechanical loads from being transferred between the tissues and the conduit. The mechanical discontinuity causes a crevice between the tissues and the conduit to open and close when the conduit is mechanically stressed, or when the tissues move during normal muscle usage, thus promoting bacterial invasion.
In order to reduce the ever-present threat of infection associated with ercutaneous conduits, devices to improve the tissue interface at the percutaneous area or zone (dermis- and epidermis-conduit interface) have been constructed. The use of porous material which promotes tissue ingrowth from the tissue layers below the epidermis has shown effectiveness in inhibiting epidermal downgrowth (sinus tract formation) and promoting a seal at the epidermal- and dermal-conduit interface (Lee, U.S. Pat. 3,663,965; Borsanyi, U.S. Pat. No. 4,278,092). However, porous materials with interconnected porosity, such as velours, felts, foams, and sponges, have a disadvantage in that once infected, the material acts as a wick, allowing the bacteria to colonize the pores filled with wound exudate and wound debris in areas not readily accessible to host defense cells.
Other attempts at combating bacterial infection related to percutaneous conduits involve the application of antibacterial agents, either to the conduit surface (Crossley, U.S. Pat. No. 4,054,139), or in a fluid reservoir device constructed around the conduit in the subcutaneous tissue just below the conduit exit site (Kitrilakis, et al., U.S. Pat. No. 3,699,956).
Several problems arise when using a tissue interfacing device at the percutaneous interface to help reduce the incidence of infection. The use of devices which have bulky subcutaneous flanges (Faso, U.S. Pat. No. 4,217,664) or antibacterial fluid reservoirs (Kitrilakis, supra) require surgical manipulation of tissues to properly place the device. If the device has a tissue sealing design using porous material such as a velour sleeve, the material should be located close to the dermis-conduit interface. Misplacement in the intracorporeal direction will allow mechanical discontinuity at the critical dermis-to-conduit interface, and also will not allow the epidermis and dermis to grow into the porous material to provide a bacterial seal. Misplacement in the extracorporeal direction will create passageways for bacteria through the pores and immediately introduce external skin bacteria to colonize the porous material.
Also, when implanting a percutaneous conduit with an attached percutaneous device, or otherwise designated percutaneous area, the length of conduit from the percutaneous exit site to the intracorporeal end is desired to be variable, to allow for the anatomical geometry of the particular patient. Inaccuracies involved in estimating this length may cause the improper location of the percutaneous tissue-interfacing device in the tissue layers of the integument, the improper location of the intracorporeal end, undesirable slack in the conduit, or a need for trial fittings to establish the correct length.
The percutaneous tissue-interfacing device of this invention is easily positionable along the conduit length to provide flexibility for optimal device placement during the surgical procedure. Additionally, the ability to be quickly positioned and attached to a preexisting percutaneous conduit allows the device to be used as an optional measure for patients at high risk for infection.
The invention comprises a tissue interface device designed to be placed onto a separate percutaneous conduit and positioned along the conduit length to a desired anatomical site for effective infection resistance. The invention can be implemented at the time of conduit implantation, or at a later time at the discretion of the clinical practitioner, due to a design which allows the tissue interface device to be implanted from the extracorporeal side using the wound created for conduit entry.
Briefly, the invention comprises a sleeve with elastic properties which is dilated with the aid of a special introducer and is then placed over a conduit or catheterlike device. The dilated sleeve and introducer may then be moved near the external catheter hub or proximal end, to be out of the way during surgical placement of the distal or intracorporeal portion of the percutaneous conduit. As a final step, the sleeve-introducer combination is moved along the conduit, placing the sleeve into the subcutaneous tissue just beneath the conduit skin exit site. When the introducer is removed, the elastomeric properties of the sleeve material cause its diameter to decrease, resulting in radial compression against the conduit, thus securing the sleeve.
The outer tissue-interfacing surface of the device is designed to reduce the incidence of infection related to percutaneous conduits by two basic mechanisms: (a) promotion of a tissue-to-conduit seal at the skin (epidermis, dermis, and adjacent subcutaneous tissues) to conduit interface, and (b) the use of antibacterial agents incorporated into the device to reduce the possibility of bacteria colonizing the foreign materials (especially during the initial formation of a tissue seal) and advancing along the conduit into deeper tissues. In addition, the use of a tissue ingrowth material provides mechanical fixation of the percutaneous conduit without the use of sutures, thus discouraging accidental conduit displacement.
The inner conduit-interfacing surface of the sleeve is designed primarily for firm frictional contact with the conduit, but can be composed of an elastomer impregnated with an antimicrobial agent to prevent bacterial invasion between the device and conduit. Such an inner sleeve surface also acts as a "bacterial squeegee" to prevent contamination should the extracorporeal side of the conduit slip through the sleeve into the tissues.
FIG. 1 shows the anatomical relationship between a percutaneous conduit, the skin and the body surface;
FIG. 2 illustrates the relationship between a conduit, a sleeve and an introducer;
FIG. 3 shows how a sleeve is positioned by an introducer on a conduit;
FIG. 4 shows differently shaped conduits in cross section;
FIG. 5 shows a conduit with longitudinally placed tissue ingrowth material;
FIG. 6 shows a presently preferred embodiment of a sleeve according to the invention;
FIG. 7 shows one type of introducer;
FIG. 8 illustrates the use of an introducer of the type shown in FIG. 7;
FIG. 9 illustrates an alternative embodiment of an introducer;
FIG. 10 shows an alternative embodiment of the sleeve of FIG. 2;
FIG. 11 shows another alternative embodiment of a sleeve; and
FIG. 12 shows yet another embodiment of a sleeve, where the sleeve is wound around the conduit.
Referring to FIG. 2, a first-embodiment device of the present invention is a resilient sleeve 10 having a relaxed inside diameter smaller than the outside diameter of a conduit such as a catheter 11 on which the sleeve will be mounted. The catheter may be provided with a conventional syringe fitting or similar connection hub 12 (FIG. 3) at its outer or proximal end. The term "conduit" is herein used in a general sense to include hollow tubular catheters as well as other types of elongated body-insertable members (either solid or hollow) such as electrical leads or orthopedic pins.
To enable fitting of sleeve 10 over catheter 11, the sleeve is elastically dilated by an expansion tool or introducer 13 (further described below) which is inserted into the sleeve bore and activated to expand the sleeve diameter. The implantable distal end of the catheter is then inserted through the introducer and expanded sleeve to position the sleeve temporarily toward the catheter proximal end adjacent hub 12. If the catheter is not provided with a hub or similar enlargement at it proximal end, this preliminary step of threading the sleeve on the catheter can be deferred until the distal catheter end has been implanted.
After this preliminary step of positioning the sleeve, the distal end of the catheter is implanted using appropriate conventional surgical tecnhiques, and the various components are then positioned as shown in FIG. 3A which illustrates an alternative introducer 15 described below. When catheter positioning is completed, the introducer is again activated to expand the sleeve so it can be slipped along the catheter into the tissues just beneath the skin surface as shown in FIG. 3B. Activating finger pressure on the introducer is then released, enabling the introducer to be withdrawn from the sleeve by a slight side-to-side rocking or lateral wiggling motion combined with a rearward extracting force moving the introducer proximally out of the bore of the implanted sleeve.
Essential to the positionability of the device is the elastic property of the sleeve material. This allows high material strain, corresponding to large device dilation, and use of the stored strain energy to provide a radial clamping force upon release. The high deformability of the elastomeric material also provides clamping and sealing of sleeve 10 to the catheter of similar conduit, even if the conduit cross-section is ellipsoid (FIG. 4A) or has a complex geometry (FIGS. 4B and 4C). Any elastomer with negligible stress-relaxation properties and a high elastic limit is suitable mechanically. It is also desirable from a physiological viewpoint that the elastic material have minimal inflammatory effect on the surrounding tissue. Several types of medical grade elastomers, such as polydimethyl siloxanes (silicone rubbers) or related polymers, polyurethanes and polyisoprenes are suitable.
Essential to the infection reduction properties of the invention is the outer tissue-interfacing surface of sleeve 10. The surface is desired to express both antibacterial activity and tissue sealing properties.
The antibacterial properties can be conferred by (1) bulk incorporation of antibacterial agent into the sleeve material, (2) surface coating of antibacterial agent, or (3) attachment of a tissue ingrowth promoting material with incorporated antibacterial activity. In some applications, it is desirable to provide these antibacterial properties within the sleeve bore as well as on the outer surface. The tissue sealing properties can be conferred by (a) the attachment of porous, tissue ingrowth promoting material, such as woven felts, and velours, textured polymers, and foam or spong-like materials, (2) the surface texturing of the sleeve material by high energy bombardment or salting out methods; (3) the attachment or incorporation of tissue adhesive biomolecules such as lectins.
Generally, the tissue-interfacing sleeve of this invention will have antibacterial surface properties conferred by one of the methods previously described. It is also preferrd to have tissue adhesive properties without the use of relatively permanent porous tissue ingrowth materials. The use of adhesive biomolecules on the outer surface, or biodegradable tissue ingrowth materials such as collagen sponge, or a combination of the two, is preferred, as ease of device removal will not become compromised.
In a second embodiment of the present invention, shown in FIG. 5, a resilient sleeve 20 will have an irregularly surfaced porous tissue ingrowth material 21, attached on the outer sleeve surface in longitudinal strips for sufficient radial dilation. The ingrowth of subcutaneous and dermal tissue into the pores will form a seal around the conduit, reducing the sinus tract pathway for bacterial invasion around the catheter. As ingrowth materials with interconnecting porosity (i.e., velours, felts, foams, sponges) can conduct bacterial infection once established, such materials will incorporate an antibacterial agent to prevent bacterial "wicking." Additionally, it is desirable to use biodegradable materials for the ingrowth layer, so that when catheter removal is indicated, the ingrowth material can be left in situ for resorption, thereby alleviating the need for surgical excision. Some potential resorbable materials are sponges or foams prepared from collagen, polypeptide, polyactic acid, and polyamino acids. Surface texturing can be used in combination with incorporation of antibacterial activity into or onto the sleeve material as previously described.
The thickness, inside diameter and outside diameter of the sleeve will depend on the outside diameter of the conduit and its radial compliance, the properties of the sleeve material, and the coefficient of friction between the conduit outer surface and the sleeve inner surface. The dimensions of a compliant sleeve material are less critical than in a material which is less compliant. Similarly, the greater the coefficient of friction of either the conduit or sleeve, the less the sleeve will tend to slide longitudinally on the conduit, leading to a correspondingly reduced need for radial compression of the conduit by the sleeve to fix the latter in place. The thickness of an attached porous ingrowth layer will depend on the outside diameter of the sleeve, the expected loads on the percutaneous interface, the degradation rate of the ingrowth layer if it is biodegradable, and the intended period of clinical use.
Yet another and presently preferred embodiment of the invention is shown in FIGS. 6A-D which illustrate a sleeve assembly 25 having a corelike resilient sleeve 26 (preferably molded from a medical-grade silicone elastomer) of somewhat "dogbone" or "barbell" shape. The opposed ends of the sleeve are reduced in diameter to form outwardly tapered leading and trailing (distal and proximal) end surfaces 27 and 28. As in the other embodiments already described, the sleeve has a central bore 29 extending therethrough, and the bore has a relaxed inside diameter somewhat smaller than the outside diameter of a catheter 30 (FIG. 60) or a similar implantable conduit on which the sleeve assembly will be installed.
Sleeve 26 is reduced in diameter between tapered end surfaces 27 and 28 to define an annular recess 32 into which is fitted a cylindrical ring-like porous sponge 33 (made of any of the materials described above, but preferably of cross-linked collagen) impregnated with an antimicrobial agent. The inner surface of the sponge is secured to the outer surface of sleeve 26 in recess 32 by a thin layer of adhesive 34 (a conventional medical-grade silicone-elastomer adhesive is suitable).
The sponge is dilated to fit over one of the enlarged ends of sleeve 26 into recess 32, and then permitted to resiliently contract against the sleeve and adhesive. To simplify this installation process, the sponge can be formed in two short sections 33a and 33b which abut each other at their inner ends, and which fit snugly between the end walls of the sleeve recess. Alternatively, the sponge (formed either as a unit or as multiple elements) can be held in a sleeve mold (not shown) so the sleeve can be molded in situ within the sponge.
After initial installation as shown in FIGS. 6A-B, the sponge is compressed in a die to be reduced in outside diameter (as shown in FIG. 6C) so the sponge is confined within recess 32, and the sleeve assembly has a smooth cylindrical appearance of constant outside diameter between the tapered end surfaces. The sponge material maintains a "set" in the compressed position until exposed to tissue fluids as described below, thereby easing insertion of the sleeve assembly into the tissue.
Assembly 25 is fitted over the catheter using a dilating introducer as already described, and this step is completed prior to catheter implantation if the catheter has a hub at its proximal end, or can be delayed until after implantation for a hubless catheter. In either event, the sleeve is again dilated with the introducer after the catheter is implanted, and the expanded sleeve is slipped along the catheter to a position just beneath the skin. The introducer is then removed as described above to leave the sleeve in tight, resiliently clamped engagement around the catheter.
Tapered end surfaces 27 and 28 assist in both implantation of the sleeve, and in healing of the catheter entrance incision. The leading taper allows easy mechanical entry of the device into a very small incision to insure a snug fit and good bacterial seal. The trailing taper allows the natural skin elasticity to close the incision after the sleeve is placed in subcutaneous tissue, helping to prevent dislodgement of the sleeve and catheter during incision healing. The aforementioned compression of sponge 33 into the sleeve recess similarly assists in implantation of the sleeve assembly in a small incision, and minimizes risk of sponge damage during this installation step.
Within minutes after subcutaneous placement of the sleeve assembly, sponge 33 absorbs water from the surrounding tissue, and swells as shown in FIG. 6D to provide nearly immediate mechanical stabilization prior to tissue ingrowth, thus insuring a snug fit within the tissue as is essential for an early bacterial seal. The sponge will typically double in volume as fluid is absorbed, providing the desired significant radial expansion, tight tissue contact, and favorable ingrowth surface. Most of the expansion desirably occurs in the central part of the sponge due to frictional contact of the spong end surfaces with the sidewalls of recess 32.
In a typical configuration suitable for fitting over a 16-gauge medical catheter or comparable conduit, sleeve 26 has an inside diameter of about 0.055 inch, an outside diameter in recess 32 of about 0.076 inch, an overall axial length of about 0.234 inch, and a recess axial length of about 0.150 inch. The leading and trailing end surfaces are tapered at about 25 degrees to diminish from a maximum outside diameter of about 0.130 inch to a minimum outside diameter at the sleeve ends of about 0.093 inch.
When the catheter or similar conduit is to be removed from the patient after long-term implantation, a sharp pull on the external catheter will separate sleeve 26 from sponge 33 so the sleeve is removed with the catheter. The tissue-bound outer portion of the sponge is left in the body where it is absorbed.
Clamping force of the resilient sleeve on the catheter is primarily determined by the size of the sleeve bore which is somewhat smaller than the catheter outside diameter, but is also somewhat dependent on the frictional characteristics, wall thickness, radial compliance, and durometer of the materials used, and the relative sizes of the sleeve and catheter which establish the surface areas which are in frictional contact. Typically, the relaxed inside diameter of the sleeve is selected to be in the range of 80-95 percent of the catheter outside diameter, with smaller sleeves being toward the low end of this range to offset the diminished area of surface contact between the sleeve and catheter. The clamping force should be sufficient to require about one pound of axial (shear) force before relative movement between the sleeve and catheter is permitted.
In certain applications of the sleeve of this invention, it may be desirable to dimension the sleeve bore to be closer to a slip fit over the conduit. For example, orthopedic pins used in bone-fracture cases sometimes extend from the bone percutaneously to an external supporting fixture. In such cases, it is desirable to provide a low-force slipping engagement between the pin and tissue-embedded sleeve to permit relative movement of the pin and sleeve. Similar requirements may arise with percutaneous conduits such as electrical leads or diagnostic catheters.
In these limited-motion applications, the sleeve bore is only slightly smaller than the conduit diameter, and preferably the sleeve bore is provided with an antimicrobial substance to prevent bacterial invasion from the skin inwardly along the sleeve-conduit junction. The sleeve then acts as a bacterial "squeegee" which wipes and inactivates bacteria on the conduit surface during conduit-sleeve movement, thereby maintaining a bacterial seal at the skin interface.
With further reference to the introducers briefly mentioned above, these tools are used to dilate the sleeve to allow its positioning over the conduit. The following examples are given for illustrative purposes.
FIGS. 7A-D and 8 show a cylindrical introducer 15 with a tapered end 40, a flange 41 on the other end, and perforation lines 42 (or equivalent lines of weakness) along the length of the introducer and radially opposed to each other. The perforation lines enable the introducer to be split into two sections either before installation in the sleeve, or during removal from the sleeve.
Introducer 15 is preferably manufactured in two separate pieces, one of which is shown in end and edge views in FIGS. 7B and 7C respectively. In using this introducer, the two halves are placed together as shown in FIG. 7D. Tapered end 40 of the introducer is then pushed into a sleeve 10 (configured according to the invention), dilating it, and the assembly of introducer and sleeve is pushed onto the conduit as shown in FIG. 8. When the sleeve is correctly positioned, the two halves of the introducer are pulled apart to slip from within the sleeve.
An advantage of the two-piece design is that the introducer may be easily removed from the site of conduit implantation without threading the length of the conduit through the introducer. The introducer may be formed of a plastic material or of metal, but is preferred that the material be slightly flexible. An advantage of using a plastic material is that the introducer may be both sterile and disposable.
An alternate embodiment of a "scissor" introducer 13 as shown in FIGS. 9A and 9B, and using two arm-like components joined at a pivot 50, allows the sleeve to be placed over split cylinder sections 51 and 52, and dilated when pressure is applied to actuation pads 53 and 54. The introducer and sleeve are placed over the catheter or conduit, and brought to the desired location. The pressure on the actuation pads is released as the introducer is pulled away from the sleeve, leaving the sleeve on the conduit.
Any rigid polymer which is readily sterilizable and moldable is suitable for the construction of the introducers. Some examples are polyethylene, polypropylene, and polysulfone. An introducer design such as just described is not permanently deformed during use, and can be reused. A variety of metals and rigid polymers are suitable for its construction.
Alternative sleeve-like designs utilizing elastic components to provide residual clamping force for fixation are possible, combined with the tissue sealing components and the incorporation of antibacterial activity as previously described.
FIG. 10 shows a composite device design utilizing elastomeric components 60 to provide positionability of the device, and is a simple modification although device complexity is increased. Such a sleeve may be formed in two parts comprising an elastomeric region 60A and a nondistensible region 60B bonded to elastomeric region 60A.
A discontinuous sleeve 65 with, for example, a C-shaped cross-section when deformed is shown in FIGS. 11A-B. This sleeve can be placed without high dilation by pressing a conduit through a slit-like opening 67 into a central lumen 68. Release of the device will allow elastic return to apply a clamping force, although not as efficiently as an integral, cylindrical sleeve. This embodiment of the invention can also be used with the introducers already described.
A coiled sleeve 70 shown in FIG. 12 consists of a strip of resilient material wound into a helical sleeve which can be deformed and placed around a catheter-like tube without high material deformation, yet utilizing the deformation to provide a residual clamping force, although the magnitude of the force will not be as great as in the previously described embodiments. An advantage of coiled sleeve 70 is that an introducer is not required.
Finally, it should be emphasized that these designs may also be used to secure conduits in deep tissue sites, as, for example, when electrical leads need to be implanted in regions of high mobility such as joints, blood vessels, the heart, or in the bowel.
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|U.S. Classification
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|International Classification
|Cooperative Classification
|European Classification
|May 13, 1986
Owner name: VITAPHORE CORPORATION, 887-D INDUSTRIAL ROAD, SAN
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST.;ASSIGNORS:YAMAMOTO, RONALD K.;PESOTCHINSKY, SOPHIA;REEL/FRAME:004565/0582
Effective date: 19860512
|Nov 26, 1990
|Fee payment
Year of fee payment: 4
|Nov 21, 1994
|Fee payment
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|Dec 21, 1998
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text:
Bridge Refurbishment Works to Commence on C67 Masterton Road
3 August 2016
Refurbishment of the bridge over the M90 on the C67 (Masterton Road) will commence at 8 p.m. on Thursday 4 August, continuing for approximately four weeks.
To ensure the safety of workers, this bridge will remain closed to vehicular traffic until the works are completed. Diversion routes will be clearly signed.
The bridge will remain open to cyclists and pedestrians and there will be no impact on traffic using the M90.
The bridge refurbishment works will consist of waterproofing, concrete repairs and resurfacing. These works are considered essential in order to maintain road user safety and the continued safe operation of the structure.
Amey has already written to local residents to advise them of this scheme.


text:
Don't miss out on "Pompeii: The Exhibition" launched at the California Science Center in Los Angeles last month. The exhibit of over 150 artifacts recovered from the ancient Roman city that was destroyed by a volcanic eruption will run through Jan. 4, 2015. Tickets are on sale now at http://www.californiasciencecenter.org.
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