text:
BlackRock's Rick Rieder says the new Fed chair's transition will be normal. » Read More
By: Michael Sheetz
Leading indicators increased in June, beating expectations and pointing to an improving economic outlook. » Read More
By: Jeff Cox
Bond guru Bill Gross is warning about looming interest rate increases and the damage they can do to a debt-laden global economy. » Read More
The number of Americans filing for benefits fell more than expected, suggesting another month of strong job growth. » Read More
The median home value in June surpassed $200,000, up 7 percent from a year ago, according to Zillow.
The first round of talks revamping NAFTA will be Aug. 16-20 in Washington.
U.S., Mexican and Canadian trade officials plan to hold seven rounds of talks in a bid to wrap up the renegotiation of the NAFTA rapidly.
Trump administration officials want U.S. companies to have more access to China's economy.
Most of the Republican Party is populated by die-hard free traders who wouldn't be fans of a new version of NAFTA, Vox reports.
Seattle passed a new income tax on households earning more than $500,000, prompting the state's Republicans to revolt.
Tax-free holidays can be a bargain if you shop wisely. Here's how.
U.S. homebuilding rebounded more than expected in June after declining for three straight months.
Refinance applications surged 13 percent last week, even as mortgage rates remained steady.
Congressional Republicans have yet to enact a single piece of major legislation on taxes, health care or federal spending, Vox reports.
U.S. import prices fell for a second straight month in June amid further declines in the cost of petroleum products.
Morgan Stanley Asia's former chairman, Stephen Roach, debunks China "doomsday" scenarios.
Homebuilder confidence falls sharply due partly to fears over rising material costs.
The House Budget Committee unveils a spending proposal that would boost funding for defense but dramatically reshape social programs.
A private sector advisory group is calling for TPP language to be included in the NAFTA renegotiation.
The jump in international purchases follows a year-ago retreat and comes as a surprise, given the current strength of the U.S. dollar.
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text:
Poroshenko advised the children of the DNI and the LC to learn English
President of Ukraine Petro Poroshenko met with foreign volunteer English teachers on the program of social organization GoGlobal.
The Ukrainian leader said that he would be happy if the children of the DNI and LC will participate in the program.
"They are in terrible humanitarian conditions where there is no food, money, schools, kindergartens, pensions, drugs… And when they get to our territory, they will realize that Ukraine is something quite different, — said Poroshenko, noting that learning English is an important step on Ukraine's way to Europe.
Ukraine and the EU. Chronicle of eventsRelated posts:

subset: commoncrawl


text:
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text:
Game developers have prepared a DNA Studios, which this project first so that approached him in some detail. In any case, the simplicity of the game offsetting at least some interesting feed. Anyway, a little plot to the game, they added!
The game's plot, as shown in the first movie, tells about the distant future, when the entire planet is covered with ice. Ants born cunning plan - dawdle deep underground, where the warm core of the planet and live there, that's exactly what we have to implement.
Dipping process is divided into levels, each of which can be completed by one, two or three larvae, there will be no stars. Larvae must be chosen during the excavation, which at the beginning will be quite easy, but then, as usual, more and more difficult.
The ant will move down at the same time it is necessary to carefully guide it up to you - namely, to the larvae. The main difficulty - not to catch stones that are on the edges of the screen, as well as numerous other obstacles that will appear as the game progresses. Anyway, this seemingly rather simple and monotonous process is very addictive, and allows you to relax a little, helping ants in their difficult endeavor.
Features Antyz:
Weaknesses games Antyz:
The result: a nice and pretty simple, understandable game that really appeal to many and suitable for many that is quite rare today, found even on Android.
- Minor bugs fixed
|date of download
|The size
| Other languages
Afrikaans, Amharic, Arab, Bulgarian, Bengal, Catalan, Czech, Danish, German, Greek, English, Spanish, Estonian, Basque, Persian, Finnish, French, Galician, Hebrew, Hindi, Croatian, Hungarian, Armenian, Icelandic, Italian, Japanese, Georgian, Kazakh, Khmer, Kannada, Korean, Kyrgyz, Laotian, Lithuanian, Latvian, Macedonian, Malayalam, Mongolian, Marathi, Malay, Burmese, Norwegian, Nepali, Dutch, Polish, Portuguese, Romanian, Russian, Sinhalese, Slovak, Slovenian, Serbian, Swedish, Swahili, Tamil, Telugu, Thai, Tagalog, Turkish, Ukrainian, Urdu, Uzbek, Vietnamese, Chinese, Zulu
|The file is checked
| full network access
Allows the app to create network sockets and use custom network protocols. The browser and other applications provide means to send data to the internet, so this permission is not required to send data to the internet.
| modify or delete the contents of your USB storage
Allows the app to write to the USB storage.
| view network connections
Allows the app to view information about network connections such as which networks exist and are connected.
| read phone status and identity
Allows the app to access the phone features of the device. This permission allows the app to determine the phone number and device IDs, whether a call is active, and the remote number connected by a call.
| control vibration
Allows the app to control the vibrator.
| Receive data from Internet
| prevent device from sleeping
Allows the app to prevent the device from going to sleep.
| receive data from Internet
Allows apps to accept cloud to device messages sent by the app's service. Using this service will incur data usage. Malicious apps could cause excess data usage.
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text:
Career Services offers the following job search services to recent graduates:
- Resume, Cover Letters and Interview Preparation Workshops
- Access to the Career Centre information resources
SenecaWorks: Job board
As a recent graduate, you can access jobs on SenecaWorks for as long as you have an active Seneca email address and password.
Seneca Career Services are available for current students and recent graduates only. Once your Seneca email is deactivated, please contact Seneca Alumni.
Seneca Alumni Looking To Recruit:
If you are an employer, the expert staff at Career Services can help you meet your recruitment needs. For more information visit our Services for Employers web page.


text:
|Guru Nanak Fifth Centenary School Mussoorie
Late S. Mehtab Singh ji
Late Sdn Jasbir Kaur ji
...Achievements in 2010...
24th & 25th April, 2010 - Master Gurkirat Singh of class 7th
participated in Punjab State Sub Junior state Championship. He
scored 5 points out of 7 rounds and was awarded the certificate
of merit.
26th April, 2010 - Godiyal Memorial Cricket Tournament was
organized by the Mussoorie Cultural & Sports Association.
Different clubs & esteemed schools participated in this tourney.
The chief guest, Shri Ravinder Jugran with Mussoorie MLA, Shri
Jot Singh Gunsola and Nagar Palika President Shri O.P. Uniyal
judged Master Shantanu Siag, as the best bowler of the
tournament. Master Shantanu Siag, the all-rounder of Vincent
Hill was also selected for the Aspen Crew Uttarakhand State
Basketball Championship.
8th May, 2010 - The day was filled with a jovial air, a mood of
festivity provided all around. The campus of Shangri - La was
adorned with bright colours as the Centonians enjoyed
themselves on Fete' 2010.
15th May, 2010 - Last year being 'Runners Up', this year
Centonians set out with a firm determination to win the Mussoorie
School Sports Association Cricket Trophy. It was a tough job but
their team work made them 'The Undefeated Champions'. The
senior boys lifted the trophy, it was possible due to strategy of
the skipper Master Deepak Reddu, Master blaster Sudershan
Sharma, Master Rinku Sharma, Master Javed Alam, Master
Naveen Sharma & Master Deepak Mittal.
6th August 2010 ( Investiture ) -
"Great Leader doesn't take people where they want to be but
where they ought to be"
Leadership qualities are to be included in a student from the
grass root levels. The office-bearers get to know the importance
of authority combined with responsibility. Mr. Austine Eapen,
Deputy Inspector General of Indo Tibetian Border Police (ITBP),
Mussoorie did the honour of decorating with badges to
Centonians this year.
15th August, 2010 - ( Independence Day - Patriotic Fever ) -
Centonians celebrated the 64th Independence Day by hosting
tricolour, singing melodious national anthem & few national
songs. Indian martyrs and national leaders were glorified by way
of eloquent speeches and poetry recitation in 3 languages.
16th August, 2010 - When the children are at zenith, how can
be the mentor left behind. Mr. Thomas Francis was awarded the
most honourable designation of the year by the "Life Time
Achievement Award" in the field of sports by the Mussoorie
Cultural & Sports Association.
25th August, 2010 - The Eco Task Force organized an Art
Competition to fulfill their mission. The topic for the day was "My
Earth, My Duty". NCC boys from different renowned schools
participated in this competition. Master Preetpal Singh of class
10th was evaluated as the second best in his category. On the
occasion of the World Earth Day, several events were held in the
city. The purpose of the event was to plant trees & spread
awareness about environmental conservation.
16th September, 2010 - The Centonians left the audience
spellbound in the Inter-School Rotary Debate. This year the moot
point of discussion was "Education System Today Produces
Valueless Degree Holders". Miss Anuroop Sandhu was adjudged
as the best debater. Master Mezanuddin Ahmad bagged the
second prize. He was also selected as the best speaker in
rebutting section. Master Jaskaran S. Gujral & Master
Mezanuddin Ahmad proved their caliber in this line of fire & lifted
the most prestigious trophy.
23rd & 24th September, 2010 - The most renowned schools of
Mussoorie participated in the Table Tennis Tournament. The
tournament was organized by GNFC School which was held in
GNFCS Shangri - La. After a tough combat the junior boys lifted
the trophy & in the senior category, boys & girls were the first
runner up.


text:
34 - 24 Final
No one has shouted yet.
Be the first!
Be the first!
Who You Got?
Miami (OH)
Related News
- Ohio university pays player $712K to settle concussion suit May 4
- Football player mistaken for burglar, shot by ex-teammate Mar 20
- Big Ten football recruiting team capsules Feb 3
- Boilermakers hire DeAndre Smith as running backs coach Jan 26
- Camellia Bowl Preview Capsule Dec 18
- Appalachian State squares off against Ohio in Camellia Bowl Dec 18
- Bowls and bowls and bowls and reasons to watch all of them Dec 16
- Camelia Bowl Matchup Dec 6
- Virginia heads to Miami, set to face emotional Hurricanes Nov 6
- Stats show 'icing' kickers has been more effective this year Oct 6
- Moore-Kaaya QB matchup lends intrigue to Cincinnati-Miami Sep 30
- NCAA Football Preview - Miami-Ohio RedHawks Aug 19


text:
Your browser does not support iframes.
My perspective on the sheriff
As a retired DC cop, living at the lake, I would like to comment on some comments I read in your paper last week.
I am a fairly new resident to the county but my wife's family has lived here for approximately 20 years. My remarks are in reference to, and support of, another 'alumni' of the Metro Police Department, Sheriff Brown.
By Congressman Robert Hurt
Three out of four Americans say the current federal tax code is unfair. While this number is the result of a recent survey by the nonprofit group Let Freedom Ring, you only have to try wading through the depths of the tax code yourself to come to the same conclusion. The tax code is inherently unfair, inefficient, and mind-numbingly complex at times.
By Steve Everett
Someone asked me what is so special about the Confederate flag.
Well, I can tell you, plain and simple. To me it has a lot to do with someone I wish I could have met, my third great grandfather, Elias Newman. He, along with four of his brothers proudly served our country in the Confederate army during the bleak and horrific time in our nation's history that we call the Civil War.
Recently, it seemed that 100 years of progressive change took place in a single week. Taken together, the events were a great victory for justice, decency, and fairness under American civil law.
When we honestly try to live up to all those great words in our Constitution, what results is necessary change: an expansion of civil rights, not a continued denial for reasons of bigotry, religion, or even "tradition."
When in the Course of human events, it becomes necessary for one people to dissolve the political bands which have connected them with another, and to assume among the powers of the earth, the separate and equal station to which the Laws of Nature and of Nature's God entitle them, a decent respect to the opinions of mankind requires that they should declare the causes which impel them to the separation.
On the last Friday of June I ran into Town Councilman Beckham Stanley at the Bower Center ground breaking. The Supreme Court had just struck down state laws banning same-sex marriage and Mr. Stanley asked me if I planned to write a column telling why the Supreme Court and a majority of the American people are wrong. By a majority of the American people, I assumed he was referring to a recent poll that showed 57 percent of Americans favored same-sex marriage.
Same sex marriage
The Supreme Court decision on same sex marriage will be discussed for years to come. That pronouncement will not alter deeply held religious beliefs grounded in a biblical worldview. It determines how authentic biblical Christians perceive life and provides the best explanation for life.
Copyright © 2017
The Bedford Bulletin is your source for local news, sports, events, and information in Bedford County and Bedford, VA and the surrounding area.


text:
Lord,help me believe in what I could be and all that I am. Teach me how to always keep my head up no matter what. Lord give me strength and courage to get out of another abusive relationship,and teach me how to stand strong in faith. Lord grant me favor , and bless me with a healthy baby boy and a successful pregnancy . Father watch over all my little ones and keep them safe, be with me Lord when am having my c-section keep us safe Lord. I ask you lord in the name of Jesus Christ my Lord Amen !
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text:
|Publication number
|Publication type
|Application number
|Publication date
|Sep 10, 2002
|Filing date
|Jul 9, 1999
|Priority date
|Jul 9, 1999
|Fee status
|Also published as
|Publication number
|Sterling Eduard McBride
|Original Assignee
|Orchid Biosciences, Inc.
|Export Citation
|BiBTeX, EndNote, RefMan
|Patent Citations (12), Referenced by (54), Classifications (22), Legal Events (9)
|External Links: USPTO, USPTO Assignment, Espacenet
This application is related to U.S. patent application Ser. No. 09/351,206, now U.S Pat. No. 6,395,232 entitled "Fluid Delivery System for A Microfluidic Device Using A Pressure Pulse" filed simultaneously with the present application, the subject matter of such co-pending application being incorporated herein by reference.
The present invention relates to microfluidic devices, and more particularly, to a method and apparatus for distributing fluid on a microfluidic device.
Methods of making a homologous series of compounds, or the testing of new potential drug compounds comprising a series of light compounds, has been a slow process because each member of a series or each potential drug must be made individually and tested individually. For example, a plurality of potential drug compounds is tested by an agent to test a plurality of materials that differ perhaps only by a single amino acid or nucleotide base, or a different sequence of amino acids or nucleotides.
The processes described above have been improved by microfluidic chips which are able to separate materials in a and move the materials through the microchannel is possible. Moving the materials through microchannels is possible by use of various electro-kinetic processes such as electrophoresis or electro-osmosis. Fluids may be propelled through various small channels by the electro-osmotic forces. An electro-osmotic force is built up in the channel via surface charge buildup by means of an external voltage that can repel fluid and cause flow.
Another method for the movement of fluids is the use of an electrohydrodynamic pump. In electro-osmotic and electrohydrodyamic pumping, electrodes are placed within the microfluidic structure.
In fluid delivery in microfluidic structures, it is important to distribute approximately the same fluid volume to each reaction well. In using certain fluids, however, even distribution within reaction wells is difficult to accomplish.
It is, therefore, one object of the invention to provide an improved fluid delivery mechanism to an array of reaction wells. It is a further object of the invention to provide a reliable method for delivering fluid to reaction wells.
It is another object of the present invention to create a relatively small device which can carry out hundreds and even thousands of chemical experiments simultaneously, create new compounds, and measure their reactivities.
It is yet another object of the present invention to provide a liquid handling drug discovery and diagnostic tool which increases the speed and productivity of discovering new drug candidates and does so on a miniaturized scale or platform that reduces cost and manual handling. It is still a further object of the present invention to provide a multiple fluid sample processor, system and method which is capable of conveying, transporting, and/or processing samples in a large multiplicity of sites without exposure to the atmosphere.
In one aspect of the invention, a microfluidic fluid delivery system includes a microfluidic chip having a fluid input. A fluid reservoir is coupled to the fluid input. A gas delivery system has a gas pressure source and a variable amplitude function generator generating an alternating signal. A valve is coupled to the function generator and the gas pressure source. The valve controls the gas pressure in response to said alternating signal. The gas pressure displaces fluid from the fluid reservoir into the fluid input.
In a further aspect of the invention, a method of distributing fluid to a microfluidic chip comprises the steps of: providing a reservoir having fluid therein; generating an alternating pressure to cyclically pressurize fluid within a microfluidic device; filling capillary channels in the microfluidic device until each channel is filled to a capillary break; increasing the amplitude of the alternating pressure; and thereby, overcoming the capillary break in response to the increase in the amplitude.
One advantage of the invention is that small and controlled amounts of fluid may be delivered in an array structure with microchannels that have high pressure losses. Another advantage of the invention is that the method for delivering fluid to microfluidic structures is applicable to structures having high integration densities and where viscous losses in microchannels are significant.
Other objects and features of the present invention will become apparent when viewed in light of the detailed description of the preferred embodiment when taken in conjunction with the attached drawings and appended claims.
FIG. 1 illustrates a multiple fluid sample processor according to the present invention;
FIG. 2 is an exploded view of the processor shown in FIG. 1;
FIG. 3 is a block diagram schematic view of a microfluidic fluid delivery system according to the present invention.
FIG. 4 is a partial schematic view of an alternative embodiment of the fluid reservoir of FIG. 3 in a full state.
FIG. 5 is a cutaway view of microfluidic capillaries being filled according to the present invention.
FIG. 6 is a cutaway view such as that shown in FIG. 5 having capillaries filled to an initial state.
FIG. 7 is a cutaway view such as that shown in FIG. 5 with a reaction well in a full state.
FIGS. 8 and 8a are a pressure versus time plots of a pressure waveforms formed according to the present invention.
FIG. 9 is a plot of an upper limit pressure drop and a lower limit pressure drop along a micro channel.
FIG. 10 is a two-sided pressure head system operated in a similar manner to that described with respect to FIG. 3.
FIG. 11 is a plot of pressure versus location showing upper limit pressure drop and lower limit pressure drop along the microfluidic structure of FIG. 10.
Referring now to the drawings, like reference numerals are used to identify identical components in the various views. The present invention can be used particularly in the industrialization of drug discovery processes. The present invention increases speed and productivity while providing researchers with expended capabilities and assuring quality. The invention provides substantial time and efficiency advantages over prior techniques. The invention provides miniaturized liquid handling systems which perform the biological, chemical and the analytical processes fundamental to life sciences, research and development. The invention can be utilized to perform thousands of reactions simultaneously in an integrated format, which substantially reduces the time, effort and expense required while improving the quality of the test results.
The processor in accordance with the present invention generally incorporates a modular configuration with distinct layers or plates. The processor or microfluidic device 16 is capable of conducting parallel synthesis of thousands of small molecule compounds through the precise delivery of reagents to discrete reaction sites. This helps create a significantly larger number and variety of small molecules more effectively and with fewer resources.
With the present invention, arrays of DNA can be synthesized on demands. The processor can also be used for high volume of sample processing and testing, as well as the search for new molecular targets and determining expression levels and response to known drugs. The processor can incorporate multiple assay formats, such as receptor binding, antibody-antigen interactions, DNA/RNA amplification and detection, as well as magnetic deed base separations. The versatility of the processor and its architecture make it available for use with synthesize work stations, genomic support stations, and analytical preparation systems.
A basic multiple fluid sample processor or microfluidic device 16 in accordance with the present invention is shown in FIGS. 1 and 2, with cross-sections of the layers being shown in FIGS. 5, 6, 7 and 8. The microfluidic device is illustrated as a three-layered structure in the embodiment illustrated. The microfluidic device 16 is also called a fluid assay layered device (FALD), or a fluidic array.
The microfluidic device 16 includes a top layer 7, which is also called a reagent reservoir. The microfluidic device 16 also includes a middle layer or fluidic delivery layer 8, as well as a bottom layer or well plate 9.
The top layer 7 is also called a feed-through plate and serves as a cover for the microfluidic device 16. Layer 7 contains a number of apertures 11 which are selectively positioned immediately above apertures 13 in layer 8. Apertures 13 are connected by an elongated micro-channel 48 which in turn have a plurality of branches extending therefrom. As illustrated, layer 8 contains one layer, however, one skilled in the art would recognize that layer 8 may comprise several layers.
Well plate 9 has a plurality of wells 15 which are used to hold the reagents and other materials in order for them to react and synthesize.
The three layers 7, 8 and 9 are stacked together to form a modular configuration. They are also coupled together tightly to form a liquid-tight seal. If desired, the top layer 7 can be bounded or fused to the center distribution plate 8 or layer. The bottom or well plate layer 9, however, is detachably coupled to layer 8.
The plates 7, 8 and 9 may be made from any desirable material, such as glass, fused silica, quartz, or silicon wafer material. The reservoirs, micro-channels and reaction cells are controllably etched or otherwise formed onto the plates using traditional semi-conductor fabrication techniques with a suitable chemical etchant, laser drilling or reactive ion etching.
Top plate 7 contains apertures positioned above the openings 13 located in the central plate. These apertures provide the necessary openings for loading module to fill the reservoirs with a plurality of agents or other materials.
As will be further described below, a pressure pumping mechanism, is preferably used to assist in loading and distributing the reagents and other materials within the layers.
A typical need is for one of the sample plates to have each sample repeated conveyed, transported and/or processed while eventually being delivered into the well plate. During this time, the samples are typically exposed to the atmosphere and can oxidize, evaporate or cross-contaminate to an undesirable extent. With the present invention, however, the multi-layered sample microfluidic device 16 with detachable well plates inhibits cross-contamination of the fluids used in the combinatorial process.
The detachable layers in accordance with the present invention are preferably of a common dimensionality for ease of being handled by robotic or other automation means. A common set of dimensions has been adopted by many manufacturers which match that of the 96-well plate known as a "micro titer" plate.
Preferably, the plates 7, 8 and 9 are connected to each other by an indexing means of detents, flanges or locating pins so they are closely aligned in the horizontal and vertical directions. While engaged in such manner, samples from one of the plates can be caused to be moved and transported to another plate. Means for transporting or moving the samples from one of the plates to the other can be by pumping, draining, or capillary action. While the samples are engaged, and as a result of the transport of the samples from one layer to the other, the samples may be processed, reacted, separated, or otherwise modified by chemical or physical means, and then finalized by optical, electrochemical, chemical, or other means.
Samples or fluids can be delivered to the microfluidic device 16 by being contained in one of the members of physically engaging sample multi-well plates, such as a top layer 7, or other means of sample introduction can be utilized, such as through the edges of such layer.
Referring now to FIG. 3, a microfluidic fluid distribution system 10 is shown having a gas distribution system 12 coupled to a fluid reservoir 14. Fluid reservoir 14 is fluidically coupled to a microfluidic device 16. In general, gas distribution 12 is used to displace fluid from fluid reservoir 14 into microfluidic device 16.
Gas distribution system 12 has a gas input 18. The type of gas in gas input should be of the type not to react with reagents in the microfluidic device 16. For example, for many applications, nitrogen may be a suitable gas. Gas input 18 provides a high pressure source of gas to gas distribution 12. The pressure of gas input 18 is preferably at least the highest pressure desired in gas distribution system 12.
Gas distribution system 12 has a pressure regulator 24 and a pressure sensor 26. Pressure regulator 24 is preferably a programmable pressure regulator so that a desired constant pressure may be generated.
Gas distribution system 12 also has a valve 30. Valve 30 may, for example, be a solenoid valve. Valve 30 is coupled to a function generator 34 which generates an alternating electrical signal to control the valve 30 which in turn controls the pressure to fluid reservoir 14.
A second valve 30′ connected to a second function generator 34′ may also be used. Second valve 30′ is coupled between chip 16 and fluid reservoir 14. Second valve 30′ may be used in place of valve 30′.
A computer controller 38 that controls the operation and distribution of gas from gas input 18 to fluid reservoir 14 through valve 30. Computer controller 38 has a user input (not shown) for providing the control. That is, the various pressures desired at pressure regulator 24, and the desired timing of pulse generator 34 may be controlled by computer controller 38. Computer controller 38 uses feedback from pressure sensor 26 to control the operation of gas distribution system 12. Computer controller 38 is also coupled to function generator 34.
Computer controller 38 is also coupled to second function generator 34′. When using two valves 30 and 30′, the valve 30 may be opened to pressurize the reservoir 14 while valve 30′ may be used to control the flow of fluid to chip 16,
Referring now to FIG. 4, a piezoelectric transducer device 42 may be used in place of valve 30 so that the piezoelectric transducer applies the alternating pressure to fluid reservoir 14.
Referring now to FIG. 5, the operation of the microfluidic distribution system 10 is best described with respect to microfluidic device 16. Microfluidic device 16 has an input 46 that is coupled to fluid reservoir 14. Input 46 is coupled to a main channel 48. Main channel 48 has various branches 50 that fluidically couple main channel 48 to reaction well 52. As is shown, ten reaction wells 52 are illustrated. However, various numbers of reaction wells 52 may be employed. The number of reaction wells 52 could approach 10,000 all of which may be coupled to a single fluid delivery system. The wells may also be grouped together and be serviced by several fluid delivery systems. Branches 50 have a cell feed 54 and a capillary stop 56. As shown, fluid 58 has entered through input 46 and has filled the first branches 50 up to capillary break 56. The flow of fluid 58 is initiated through computer controller 38. The pressure supplied is insufficient to break the capillary stop 56.
Referring now to FIG. 6, each branch 50 is shown filled up to capillary stop 56. Branches 50 are filled sequentially from the closest to fluid input 46 to the most distant from fluid input 46.
Referring now to FIG. 7, fluid has now entered reaction well 52. The gas waveforms displace a fluid from fluid reservoir 14 into microfluidic device 16 through input 46. The pressure Is large enough to overcome the capillary stop 56 in each of branches 50.
Referring now to FIG. 8, a suitable high alternating pressure signal is illustrated. In one constructed embodiment, a signal 60 has a first amplitude during time T1 and a second amplitude during time T2. The increase in amplitude allows the capillary break to be overcome. Of course, other means for increasing the mean signal may be used such as increasing the frequency during time T2.
Referring now to FIG. 8a, a function generator may be used to generate pressure waveforms that range from square waves to sinusoidal waves. Signal 60′ approaches a sinusoidal wave having two different amplitude portions. The lower amplitude portion is used for filling the capillaries of the chip up to the capillary break. The higher amplitude portion is used for breaking the capillary break.
The second higher amplitude regions of the signals 60, 60′ may be continued to not only fill the wells on the chips, but may also be used to dispense fluid from the chips. The waveforms may be controlled to provide full or partial well filling.
Referring now to FIG. 9, a plot showing upper limit pressure drop along main channel 48 for stagnant fluid flow is shown by line 62. As will be evident to those skilled in the art, the pressure along main channel 48 decreases as the distance from fluid input 46 increases due to the pressure drop along 48. Line 64 represents the pressure drop along main channel 48. The locations 1 through 10 correspond to the branches 50. Line 64 corresponds to the lower limit pressure drop along main channel 48 for a fully developed fluid flow. Area 66 between line 62 and line 64 corresponds to a transient region of the operation of a microfluidic device 16. As the distance from fluid input 46 increases, the lower limit line 64 approaches to zero.
Referring now to FIG. 10, to overcome the decrease in pressure due to the distance from the input, a first input 46′ and a second input 46″ may be coupled to main channel 48 at opposite ends.
Referring now to FIG. 11, transient area 66′ has been reduced significantly by adding a second fluid input 46″. The lower limit pressure drop denoted by line 64′ is thus may be reduced to about 50 percent of the upper limit line 62′ compared to almost zero with a single input as illustrated in FIG. 9.
While particular embodiments of the invention have been shown and described, numerous variations and alternate embodiments will occur to those skilled in the art. Accordingly, it is intended that the invention be limited only in terms of the appended claims.
|Cited Patent
|Filing date
|Publication date
|Feb 28, 1990
|Jun 30, 1992
|Soane Tecnologies, Inc.
|Method and device for moving molecules by the application of a plurality of electrical fields
|Sep 1, 1992
|Aug 31, 1993
|Shimadzu Corporation
|Capillary electrophoresis system and method
|Dec 27, 1993
|Oct 25, 1994
|Hewlett-Packard Company
|Method and apparatus for injecting liquid into a capillary tube
|Jul 27, 1995
|Mar 18, 1997
|Aisin Seiki Kabushiki Kaisha
|Aug 31, 1992
|Jun 17, 1997
|The Regents Of The University Of Calfornia
|Microfabricated reactor
|Jun 7, 1995
|Jul 8, 1997
|Hewlett-Packard Company
|Low voltage miniaturized column analytical apparatus and method
|Jan 21, 1994
|Aug 5, 1997
|Parton; Adrian
|Methods of analysis/separation
|Sep 28, 1995
|Sep 16, 1997
|Dionex Corporation
|Pressure injection apparatus and method for injecting a sample into an electrophoresis capillary
|Mar 13, 1996
|May 12, 1998
|Soane Biosciences
|Method and device for moving molecules by the application of a plurality of electrical fields
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|Life Technologies Corporation
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|The Charles Stark Draper Laboratory, Inc.
|Drug delivery apparatus
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|California Institute Of Technology
|High throughput screening of crystallization of materials
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|Dec 15, 2015
|Life Technologies Corporation
|Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
|Jun 8, 2013
|Oct 4, 2016
|Life Technologies Corporation
|Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
|Nov 13, 2015
|Jan 10, 2017
|Life Technologies Corporation
|Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
|Dec 17, 2010
|Feb 28, 2017
|Abbott Point Of Care, Inc.
|Biologic fluid analysis cartridge
|Apr 16, 2010
|Apr 18, 2017
|Fluidigm Corporation
|Integrated chip carriers with thermocycler interfaces and methods of using the same
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|Membrane-based fluid control in microfluidic devices
|Mar 19, 2015
|May 23, 2017
|Fluidigm Corporation
|Short cycle methods for sequencing polynucleotides
|Apr 27, 2010
|Jul 4, 2017
|Abbott Laboratories
|Apparatus for performing counts within a biologic fluid sample
|Aug 15, 2003
|Feb 17, 2005
|Peter Massaro
|Method and apparatus for handling small volume fluid samples
|Oct 15, 2003
|Apr 21, 2005
|Caren Michael P.
|Methods and apparatus for mixing of liquids
|Feb 28, 2005
|Jul 7, 2005
|Caliper Life Sciences, Inc.
|Distributed database for analytical instruments
|Jan 25, 2005
|Sep 15, 2005
|Fluidigm Corp.
|Crystal forming devices and systems and methods for using the same
|Feb 14, 2005
|Sep 29, 2005
|Fluidigm Corporation
|Integrated chip carriers with thermocycler interfaces and methods of using the same
|Jun 28, 2005
|Oct 27, 2005
|The Charles Stark Draper Laboratory, Inc.
|Electromagnetically-actuated microfluidic flow regulators and related applications
|Jan 28, 2005
|Feb 9, 2006
|The Charles Stark Draper Laboratory, Inc.
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|Jacob Rosenstein
|Method and apparatus for controlling microfluidic flow
|May 1, 2006
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|May 2, 2005
|Nov 2, 2006
|General Electric Company
|Valve and pump for microfluidic systems and methods for fabrication
|Apr 20, 2006
|Dec 14, 2006
|Fluidigm Corporation
|Analysis engine and database for manipulating parameters for fluidic systems on a chip
|Mar 21, 2007
|Jul 26, 2007
|California Institute Of Technology
|Systems and methods for mixing reactants
|Jan 29, 2007
|Sep 13, 2007
|California Institute Of Technology
|High throughput screening of crystallization materials
|Jan 31, 2008
|Oct 9, 2008
|Mescher Mark J
|Membrane-based fluid control in microfluidic devices
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|Symyx Technologies, Inc.
|High throughput dissolution and precipitation apparatus and method
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|Method And Apparatus For Controlling Microfluidic Flow
|Dec 5, 2003
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|Steag MicroParts GmbH
|Device for parallel dosing of liquids
|U.S. Classification
|436/180, 435/286.6, 435/286.5, 137/209, 422/504
|International Classification
|Cooperative Classification
|European Classification
|Jul 9, 1999
Owner name: ORCHID BIOCOMPUTER, INC., NEW JERSEY
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text:
CR Gutters, Inc. is a family-owned business catering to Olympia, Tacoma, Seattle, Bellevue and the surrounding areas. We pride ourselves on providing professional and reliable gutter cleaning, gutter repair and quality gutter installation services. Since 1984, homeowners in King and Pierce County, Washington have trusted us to provide them with superior craftsmanship and outstanding services at competitive prices.
Feel free to use our convenient form if you would like to describe your project to us. We check our email frequently throughout the day so we will be in touch in a timely manner.


text:
Former glamour rock star Gary Glitter plied a 12-year-old fan with champagne to have sex with her after a concert, a court heard.
He subjected her to "a prolonged episode of sexual abuse involving a full range of sexual activity culminating in intercourse," the jury was told.
He had invited her to his hotel suite after a concert in 1977 while her mother was "taken elsewhere by someone else."
Later, Glitter is said to have indecently assaulted her again when she was 13 in a hotel room in Birmingham.
The rock star also allegedly indecently assaulted a 14-year-old fan in his dressing room after a concert at a night club .
This attack happened after Glitter "manipulated" his alleged victim's mother to leave them alone together, the jury was told.
A few years earlier , Glitter had attempted to rape a much younger girl at a country house and then gave her an Easter egg, the court heard.
Glitter, charged under his real name Paul Gadd, attacked his alleged victim who was under 10 at the time of the height of his fame in the 1970's, the court heard.
She had gone there with a friend and "to a little girl it must have seemed to be a magical place", said prosecutor John Price QC.
"At night he came into the bedroom where (the girls) were sleeping and the (alleged victim) awoke from her sleep to find him between her and her friend," prosecutor John Price QC said at Southwark Crown Court.
"He was drunk, she remembers a 'horrible smell' of alcohol and tobacco.
"What he had done to her caused her a great deal of pain. It was a clear and unmistakeable attempt to rape her."
Mr Price went on: "The next day Gadd behaved entirely as normal. Nothing was said to her about what he had done to her. It was during that day that he gave her an easter egg."
The alleged victim did not report what had happened to the police for 22. Years.
She only came forward in November 1998 after seeing publicity about Glitter being arrested in Bristol after child pornography was found on his computer laptop.
In 1999 he later admitted to having "a large number of images" depicting in some. Instances a full range of sexual activity taking place between adult men abd very young children."
Said Mr Price: "(The victim) first heard about (his 1998 arrest) while at work.
"It encouraged her to report it to the police for the first time what he had done to her at Easter all those years ago.
"It seemed to her that these events as she understood them from the publicity offered a better chance that she might be believed when accusing so famous and popular man of so dreadful a crime."
But the girl had already told her mother what had happened .
She told her a few weeks after Glitter had made a second attempt to molest her, the court heard.
Six years after the first alleged incident, Glitter grabbed her in his flat in Kensington and asked her to cuddle him on the bed.
Referring to the Easter incident, Glitter asked her: "Do you remember what I did to you? Did you like it," said Mr Price.
After telling her mother she told other friends too, said Mr Price.
Glitter was interviewed by the police in 1998 and he denied them. Mr Price said these allegations have only now come to court "for legal reasons, the details of which it is unnecessary to recite."
Glitter, now 70 and dressed in a black pinstripe suit, silk scarf and with tinted glasses and hearing aids behind his ears, has pleaded not guilty to 10 charges against the three alleged victims.
He denies seven counts of indecent assault, one of attempted rape, one charge of adminstering a drug to facilitate sexual intercourse and one count of sexual intercourse with a girl under 13.
The case continues.
- More about:
- Old Bailey


text:
Yeshivat Har Etzion has earned a well-deserved reputation for breaking new ground in Torah commentary. Its new Torah MiEtzion series, recently completed with the publication of a volume on Bamidbar,… Read more
To Fill The Sky With Stars: Women Explore Their Midlife Challenges and Triumphs
"Then comes a new stage in life . . ." Miriam Liebermann writes poignantly in her new anthology, To Fill the Sky with Stars. The book, a sequel to The Best Is Yet to Be, is rife with essays, by… Read more
The Covenant Kitchen: Food and Wine for the New Jewish Table
The Covenant Kitchen: Food and Wine for the New Jewish Table By Jeff and Jodie Morgan Schocken Books/OU Press New York, 2015 272 pages Reviewed by Barbara Bensoussan Opening The Covenant Kitchen: Food… Read more
Patterns in Genesis and Beyond
Patterns in Genesis and Beyond By Rabbi David Sykes Patterns Publications 2014 589 pages Reviewed by Hayyim Angel The field of literary analysis of Tanach has been substantially refined over the past… Read more
Birkas Yitzchak: Chidushim U-ve'urim al HaTorah
Birkas Yitzchak: Chidushim U-ve'urim al HaTorah By Rabbi Menachem Genack OU Press New York, 2013 Reviewed by B. David Schreiber Rabbi Menachem Genack's newest work, Birkas Yitzchak: Chidushim… Read more
The Rabbi & The Nuns: The Inside Story of a Rabbi's Therapeutic Work with the Sisters of St. Francis
The Rabbi & The Nuns: The Inside Story of a Rabbi's Therapeutic Work with the Sisters of St. Francis By Rabbi Dr. Abraham J. Twerski Mekor Press Brooklyn, 2013 190 pages Reviewed by Steve Lipman A… Read more
Collected Essays, Vol. I
Collected Essays, Vol. I By Haym Soloveitchik Littman Library of Jewish Civilization Oxford, 2013 352 pages Reviewed by Jeffrey R. Woolf Professor Haym Soloveitchik is the leading contemporary… Read more
Our New Special Baby
Our New Special Baby Written by Chaya Rosen Illustrated by Rivkie Braverman Feldheim Publishers Nanuet, New York, 2013 43 pages Reviewed by Dovid M. Cohen Our New Special Baby, written by Chaya Rosen… Read more
A Glimpse at Greatness
A story about Murray Gell-Mann and Richard Feynman, both Nobel Laureates in physics, captures some of the challenge presented by certain kinds of greatness. A student once said to Gell-Mann about some… Read more
Readings for the Yamim Noraim
With Rosh Hashanah approaching, we asked leading thinkers and educators to share with us their favorite books or seforim they rely on to help prepare for the holiness and awe of the day. Charlie… Read more


text:
Cast: Anikka Albrite, Shay Fox, Laela Pryce, Jamie Jackson, Zoey Portland
Black Listed # 3 An Interracial Epic!
Blonde big booty sensation Anikka Albrite is no stranger to the BBC, and is curious about the girth of the Jordan stick, so she brings a tape measure to see if Jovan measures up to the hype. Black Listed # 3 movie A must see scene!
Laela Pryce is a self-proclaimed BBC slut and nympho and she just wants to try and deep throat the Jovan Jordan girth!
DDD MILF Shay Fox loves everything BIG & Black including BBC so she takes on all of Jovan except for the last 2 inches!
Jamie Jackson's 1st BBC was in porn and now that's all she wants when pounded from behind!
Blonde slut Zoey Portland has been banging the BBC for a long time and now puts Jovans girth right up her ass!


text:
Tuesday, June 21, 2011
What's Behind the Door?
When you're in the work of the Lord, you meet many different types of people. As a bus captain, I have come across some really wonderful people, with great attitudes and who are a delight to talk with. There are a few people, however, that are totally the opposite as you will notice in this encounter I had just last week while visiting.
Several months ago, I was "cold calling" for the bus route. I went to several places with some really good visits. I thought I would go to one more stop before calling it a day. It was a place east of Osky just outside of town that I had seen a few children out playing. I pulled in the drive, went up to the door and knocked. A few of the kids came out and greeted me favorably. The dad came out after the kids announced "a guy was at the door."
The dad came out and I introduced myself, "Hi there, my name is Steven Dunbar from Marion Avenue Baptist Church...." I hardly finished the sentence when the man abruptly and quite rudely I might add, told me, "My kids are not going to that @&#(**& church. Get off my property now, you're done, don't you ever come back here again." He said all this as he was walking towards me saying a few more choice words, making sure I was going to leave.
Wow! Something or someone had irritated this guy! I tried apologizing the best I knew how as I was swiftly walking to my car, not trying to further aggravate the man. In a way, I wanted to burst out laughing just because of the situation, but as the Bible says, To every thing there is a season, and a time to every purpose under the heaven...that time was not that moment. I did not feel led to laugh. I believe a smile crossed my face, though. If the guy only knew my intentions were purely innocent. That encounter was a little bit of a downer, but I knew it was just the devil trying to discourage me because of the good visiting day I had.
Interestingly enough, the building they were living in has since been demolished and the place is leveled.
Last week, I saw some kids out in a yard in Osky. One was riding down their hill in a wagon. I had Bethany, my daughter, with me. We went up to the house and I said to the boy, "Hey, that looks like fun! What do think about me taking a ride?" Just kidding, I would probably hurt myself." The boy laughed.
We got to the door and saw a man that was talking on his cellphone. I thought, "This must be the dad." I really dislike introducing myself to people while they are on the phone. Generally they don't want to take the time to talk when they are on the phone. I was about to tell him I would come back some other time, but he seemed to be putting his phone away. He said, "We're getting ready to go, what do you need?"
I said, "My name is Steven Dunbar, and I'm from Marion Avenue Baptist Church... I hardly finished the sentence when the man abruptly and quite rudely I might add, told me, "Nope, No more, I have no time for Marion Avenue! We go to the Nazarene Church. Get away from here." After he said that, I realized I had met the same man I met several months ago! Pity I did not recognize him while he was on his phone. At least he did not cuss at me again. I said, "I'm sorry, I met you a while back, didn't I? I apologize! I didn't realize you moved here." I knew apologies were not going to help the situation, but I threw them out anyway. He said no more, and neither did I. Bethany and I quickly went to my car and went on our way. Bethany really did not understand anything that went on, she did get a good dose of how rude some people can be.
I chuckled and thought to myself, "Wait 'til Marchel hears this story."
Posted by Brother Steve at 8:09 AM
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text:
Jessica Jaymes – Jessica Jaymes Naughty Outdoor
Released: January 15, 2016
Jessica Jaymes Brings you in her Van Wildest fantasies :) … She gets to fuck outside near to the beach. Jessica is wearing a tiny bikini and her tits are popping out from it . She gets on her knee and sucks Van Wylde hard cock, then those 2 perverts start to fuck in doggie style all over the beach . Enjoy this amateur style shoot


text:
Hydrocortisone enemaPronunciation
Generic Name: hydrocortisone (HYE-droe-KOR-ti-sone)
Brand Name: Examples include Colocort and Cortenema
Hydrocortisone enema is used for:
Treating inflammatory conditions of the colon such as ulcerative colitis and ulcerative proctitis. It may also be used for other conditions as determined by your doctor.
Hydrocortisone enema is a topical corticosteroid. It works by decreasing inflammation.
Do NOT use hydrocortisone enema if:
- you are allergic to any ingredient in hydrocortisone enema
- you are taking interleukin-2 or mifepristone, or you will be receiving a smallpox vaccine
- you have a rectal obstruction, abscess, or perforation; recent colostomy surgery; or a systemic fungal infection
Contact your doctor or health care provider right away if any of these apply to you.
Before using hydrocortisone enema:
Some medical conditions may interact with hydrocortisone enema. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have a weakened immune system; a parasitic, bacterial, fungal, or viral infection; heart failure; diabetes; diarrhea; swelling of the esophagus; stomach problems; blockage of the bowel or other bowel problems; abnormal blood electrolyte (eg, potassium, sodium) levels; measles; tuberculosis (TB); chickenpox; shingles; or herpes infection of the eye; or if you have received a recent vaccination
- if you have a history of glaucoma, cataracts, or other eye problems; high blood pressure; weak bones; heart attack; ulcers; kidney problems; liver problems (eg, cirrhosis); underactive thyroid; nerve problems (eg, myasthenia gravis); or a positive TB skin test
Some MEDICINES MAY INTERACT with hydrocortisone enema. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Aprepitant, clarithromycin, or hormonal contraceptives (eg, birth control pills) because they may increase the risk of hydrocortisone enema's side effects
- Barbiturates (eg, phenobarbital), carbamazepine, hydantoins (eg, phenytoin), or rifampin because they may decrease hydrocortisone enema's effectiveness
- Anticoagulants (eg, warfarin), ritodrine, or smallpox vaccine because the risk of their side effects may be increased by hydrocortisone enema
- Interleukin-2 or mifepristone because their effectiveness may be decreased by hydrocortisone enema
This may not be a complete list of all interactions that may occur. Ask your health care provider if hydrocortisone enema may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use hydrocortisone enema:
Use hydrocortisone enema as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- An extra patient leaflet is available with hydrocortisone enema. Talk to your pharmacist if you have questions about this information.
- Shake well before each use.
- Wash your hands immediately after using hydrocortisone enema.
- Use hydrocortisone enema on a regular schedule to get the most benefit from it. Using it at the same time each day (usually at bedtime or as directed by your doctor) will help you remember to use it.
- Do not suddenly stop using hydrocortisone enema if your course of treatment lasts longer than 21 days. Your doctor will gradually lower your dose.
- If you miss a dose of hydrocortisone enema and you are using it regularly, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.
Ask your health care provider any questions you may have about how to use hydrocortisone enema.
Important safety information:
- Do not use hydrocortisone enema for other rectal conditions at a later time.
- Tell your doctor or dentist that you take hydrocortisone enema before you receive any medical or dental care, emergency care, or surgery.
- Do not receive a live vaccine (eg, measles, mumps) while you are taking hydrocortisone enema. Talk with your doctor before you receive any vaccine.
- If you have not had chickenpox, shingles, or measles, avoid contact with anyone who does. If you are exposed to someone who has one of these conditions, contact your doctor right away.
- If your symptoms do not get better within 2 to 3 weeks or if they get worse, check with your doctor.
- Hydrocortisone enema should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
- Corticosteroids may affect growth rate in CHILDREN and teenagers in some cases. They may need regular growth checks while they use hydrocortisone enema.
- PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using hydrocortisone enema while you are pregnant. It is not known if this medicine is found in breast milk. If you are or will be breast-feeding while you use hydrocortisone enema, check with your doctor. Discuss any possible risks to your baby.
Possible side effects of hydrocortisone enema:
All medicines may cause side effects, but many people have no, or minor side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Mild irritation or dryness.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); fever, chills, or persistent sore throat; mental or mood changes; new or worsening rectal pain, burning, itching, bleeding, or irritation; vision changes.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Hydrocortisone enema may be harmful if swallowed.Proper storage of hydrocortisone enema:
Store hydrocortisone enema at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep hydrocortisone enema out of the reach of children and away from pets.
General information:
- If you have any questions about hydrocortisone enema, please talk with your doctor, pharmacist, or other health care provider.
- Hydrocortisone enema is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information should not be used to decide whether or not to take hydrocortisone enema or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about hydrocortisone enema. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to hydrocortisone enema. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using hydrocortisone enema.
Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.
More about hydrocortisone
- Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Images
- Drug Interactions
- Support Group
- Pricing & Coupons
- 10 Reviews – Add your own review/rating
- Drug class: glucocorticoids
Consumer resources
- Hydrocortisone
- Hydrocortisone solution
- Hydrocortisone rectal foam, enema
- Hydrocortisone (Advanced Reading)
Other brands: Hydrocortone, Cortef, Solu-Cortef, Cortifoam, More... (2)


text:
You know its very annoying these past few days, as a veteran wiki editor to see so much flooding of vandalism. I feared this as we got closer to 11/10/09. But now with all the vandalism and "New"articles, its driving me crazy. I know one or two that created articles that were supposed to be user pages, and that is forgivable. It's an understandable mistake. But really a freaking article named, Please, help me to find the best dating sites. ARE YOU KIDDING ME!!!!!. This a place for good legitimate articles on the Call of Duty series and you put that up there!.
It's frustrating for us wiki vets to see such annoying trash articles posted, and we have delete them and go through almost every single article that's not protected to see if its screwed up as well. This should be an awesome time for Call of Duty fans here and on the Wiki as a new game comes out, but instead we have to play "Wiki police" track down all the insane vandalism that should have not been there in the first place.
I hope the rest of you vets out there is a vigilante and as annoyed as I am at this!


text:
Launch Week
Tons of fun events all throughout the week! Check out the facebook page for more details!
Mahila Adhyayan Kendra
Charity that works towards education and vocation for children. Please contribute here
For those of you who are new, SIA is a cultural society dedicated to enriching the lives of the South Asian community at Virginia Tech, as well as the lives of other students who are interested in the culture and traditions of this region. We participate in many events, on and off campus, as well as host our own annual show at the end of the year in the hope of sharing our culture and heritage with others.
We also encourage participation in any of the three dance teams associated with us, including VT Dhamaal, VT Bhangra, or VT Junoon.


text:
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|Tangible Fixed Assets
|£ 1,425,216
|Current Assets
|£ 124,848
|Tangible Fixed Assets Depreciation
|£ 26,108
|Provisions For Liabilities Charges
|£ 82,000
|£ 24,797
|Shareholder Funds
|£ 1,454,927
|Profit Loss Account Reserve
|£ 441,799
|Revaluation Reserve
|£ 1,000,628
|Called Up Share Capital
|£ 12,500
|Net Assets Liabilities Including Pension Asset Liability
|£ 1,454,927
|Total Assets Less Current Liabilities
|£ 1,536,927
|Net Current Assets Liabilities
|£ 111,711
|Creditors Due Within One Year
|£ 13,137
|Cash Bank In Hand
|£ 38,030
|Stocks Inventory
|£ 62,021
|Share Capital Allotted Called Up Paid
|£ 12,500
|Number Shares Allotted
|£ 12,500
|Tangible Fixed Assets Disposals
|£ 33,311
|Tangible Fixed Assets Cost Or Valuation
|£ 1,448,691
|Tangible Fixed Assets Depreciation Charged In Period
|£ 2,633
|Tangible Fixed Assets Depreciation Decrease Increase On Disposals
|£ 33,311
Information about the Private Limited Company THORNEYCROFT FARMS LIMITED has been prepared for information purposes only. It is not intended to be nor does it constitute legal advice. This is public information provided by the official company register.


text:
Sport Regional Development
A new CurlManitoba three-year program to expand resources and support services in all regions of Manitoba has been launched this week in Thompson.
The Norman introduction of the new CurlManitoba Sport Regional Development Program included 4 juniors and 12 little rockers participating in a skill development series and 4 registrants participating in the coaching course. The coaching courses included both Competition Coach training (4 team coach participants) and Train the Trainer (2 club instructor participants) initiatives. Six umpires and other club volunteers also took part in an effort to expand volunteer capacity in the region.
Over the next two curling seasons, similar programs will be offered once each in Parkland, Westman, Central, Eastman, and Interlake Regions and twice in Winnipeg.
The objective of the program is to develop athletes, coaches and umpires across the province as a support for CurlManitoba's programs and to encourage increased numbers in both member clubs and CurlManitoba events. As a part of their involvement, participants in the Sport Regional Development program are expected to be active in their own club, including organizing an Open your Doors program for their club.
Funding for the initiative includes participant registration fees, CurlManitoba development budget, and Sport Manitoba training travel grants.
While personal development is central to the program, it also includes an expectation that participants will return to their own club and conduct promotional programs and clinics as first steps in growing the sport of curling in their communities.
Plans are being developed to offer the Sport Region Development program in Central Region later this season. Over the 2016-17 and 2017-18 curling seasons the program will be offered in Eastman, Interlake, Parkland and Winnipeg Regions.
Contact CurlManitoba Development Manager Elaine Owen (firstname.lastname@example.com) or watch the CurlManitoba website (curlmanitoba.org) for details.


text:
Ermanno Gorrieri: astrology, horoscope, natal chart
Add to favourites (1 fan)
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|November 26, 1920, 6:00 AM
|Sassuolo (Italy)
|3°39' Sagittarius
|15°59' Scorpio
|5°33' Gemini
|28°27' Leo
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Mercury, Uranus, Pluto
Houses 1, 10, 7 / Water, Earth / Fixed
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Ermanno Gorrieri (November 26, 1920 - December 29, 2004) was an Italian politician and economist. Gorrieri was born at Sassuolo During World War II he participated in the resistance and was active in the creation of the short-lived Republic of Montefiorino. After the war he was a trade union activist. Between 1958 and 1963 he was a member of the Chamber of Deputies, and was Minister of Labor in 1987. One of his main interests was the problem of poverty. He authored five books and collaborated on fourteen more. Originally a member of the Christian Democratic party, he was one of the founders (with Pierre Carniti) of the socialist party Social Christians in 1993....
Celebrities born the same day: Tina Turner, Rita Ora, Ilona Staller, Eugène Ionesco, Natasha Bedingfield, Françoise Gilot, Charles Schulz, Peter Facinelli, Louis Ducruet, Louane Emera, Arjun Rampal, Ferdinand de Saussure, Marcy Walker, Jessica Bowman, Kim Rogers-Gallagher... List of all the celebrities born on November 26.
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January 26, 2011
Nielsen priced its IPO of about 71.4 million shares of common stock at $23 per share, putting the total value of the offering at about $1.6 billion. The $23 per share price is above the expected price range of between $20 and $22. The global information and measurement company is backed by AlpInvest Partners, The Blackstone Group, The Carlyle Group, Hellman & Friedman, Kohlberg Kravis Roberts and Thomas H. Lee Partners, and its shares will begin trading today on the NYSE under the symbol NLSN.
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text:
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text:
Discussion in 'XenForo Questions and Support' started by jamiewefixit, Nov 21, 2012.
How do i decide who gets the emails from the contact us form in xenforo?
Admin CP > Options > Email Options > Default Email Address
The contact form goes to that address.
Separate names with a comma.


text:
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Candidates for Marketing Manager position in LCMC- an upcoming Healthcare Company located in Anand GJ. Education- B.Pharm / MBA / BBA Work Experience- 2 years minimum Age- 25 to 40 years
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text:
Clarke "Wes" Wescoe Clemmer III, 45, of North Windham, Maine, died while skiing on March 29, 2001, in Bridgton, Maine.
Mr. Clemmer was born in Saint Louis, Mo. He grew up in Mountain Lakes, graduating from Mountain Lakes High School in 1973. Later, he lived in Maine, then Massachusetts before moving back to Maine.
He attended the University of New Hampshire and graduated from Loyola University in 1979.
Mr. Clemmer worked for American Steel Corporation in Chicago, Ill., as well as Alfred Stamley, Inc., in Beverly, Mass.
In 1983, Mr. Clemmer opened the Port Gardens Inn and Restaurant in Kennepunkport, Maine. He also owned and operated CWC Enterprises, a business consulting company, since 1989.
Mr. Clemmer was a member of the North Windham Union Church and served on its stewardship committee.
He was on the Board of Directors at the Maine State Foundation for the Deaf and Hard of Hearing.
Mr. Clemmer coached youth football and Little League baseball. He was vice president of finance for Windham Youth Football and a member of the Portland Partnership Program, as well as a volunteer for the Business Connections Trade Show.
In addition to skiing, Mr. Clemmer enjoyed boating, golfing, reading, outdoor cooking, tennis and working on his home.
Mr. Clemmer is survived by his wife, Norma-Jean Knudsen Clemmer; two sons, William K. and Garrett M., at home; his mother, Emily Clemmer of Sarasota, Fla.; three sisters, Marcia Carrier of Boonton Township, Leslie Dean of Richmond, Va., and Jeanne Watkins of Greenville, N.C.
Donations may be made to the American Heart Association, Maine Affiliate, Inc., 20 Winter St., Augusta, Maine, 04330.
Arrangements were by Dolby Funeral Home, Windham, Maine.


text:
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Men 'should be careful what they say' when datingPosted on: December 8, 2010 16:49:07
Men who are hoping to find a new partner may want to consider one writer's advice about what not to say on a first date.
In an article for Your Tango, Julie Spira advised males that there are a number of comments that can instantly turn ladies off.
It was recommended that remarks about a women's body or their own physique should be avoided, as they can be too much on an initial meeting.
Another suggestion was to not state if they have been on an online dating website for a long period of time, as this can make them look like they are not suitable companionship material.
"If you haven't met anyone online in years that led to a significant relationship, either you're a serial dater or are way too picky," she commented.
Ms Spira describes herself as an internet dating expert and is the author of The Perils of Cyber Dating.
Are you single? Why not try online dating?
Related Online Dating News
Hong Kong Phil boss "dreams of working with Jackie Chan"Posted on: April 17, 2014 16:26:26
The musical director of one of Asia rsquo s most well-known orchestras dreams of bringing in some unorthodox talent to perform with his musicians Speaking to the South China Morning...
(read more)
Lee Ryan and Casey Batchelor steam up the CBB housePosted on: January 6, 2014 17:25:01
They may have been shackled together when they entered the house but Lee Ryan and Casey Batchelor have done anything but drift apart since they were set free In fact...
(read more)
The online dating racePosted on: January 6, 2014 16:22:05
New research has revealed how likely single people are to get a message from an online dating site throughout According to MailOnline age matters more to men than women as...
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Sweethearts get engaged after failures on reality TVPosted on: January 3, 2014 19:02:42
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(read more)
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text:
With Purchase of Both Skis and Bindings (Price Adjusted in Cart)
- Description
The Völkl One, with a shape of 138-116-130mm, is designed for skiers who want a powder ski that they can also ski in chopped up crud, wind-blown snow, and even crust. The early taper in the tip and tail allow the skier to maneuver with almost no effort. A playful powder ski for easy, drifty turns.
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- Additional Information
Additional Information
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- Reviews


text:
Senior Scholars and Consultants
Our Senior Scholars have played a crucial role in the development of the Center for Service and Learning.
CSL appreciates the contributions of its Senior Scholars, Dr. Robert Bringle, Dr. Patti Clayton, and Dr. Barbara Holland. From serving as editors for the books on International Service Learning and the Research on Service Learning book series to their participation in the IUPUI Research Academy, their contributions to research on service and learning have been at the forefront of the field. Their research and tireless advocacy have been instrumental in IUPUI's attaining national status in service and learning and civic engagement. We are grateful for their past and future contributions.
Dr. Patti Clayton
Senior Scholar and Consultant
Dr. Robert Bringle
Senior Scholar and Consultant
Dr. Barbara Holland
Senior Scholar and Consultant


text:
When I was asked to review Just Food: Where Locavores Get It Wrong and How We Can Truly Eat Responsibly, I was a little apprehensive. I thought it would be about how everything with all food production was overly capitalistic and wrong, but that wasn't the focus of the book at all. The author made it clear that he would confront some "urgent but inconvenient" truths about what we eat and where it comes from. The book was more of an indictment on simplistic thinking and the food police who constantly seem to direct our attention on the wrong things. For example:
Food Miles: Easy to understand but a worthless measure
Better than using the number of miles from "the farm to the fork," the author presents a better evaluation called a life-cycle assessment (LCA). Why are "food miles" not the best way to evaluate the environmentally responsible way to eat? Because they're only a tiny fraction of the energy used to get food to your table. But it feels good, saying you only eat locally produced food, doesn't it? That means no seafood in St. Louis, no bananas in New York, and no fresh fruit in the winter for anyone.
LCA's are a much better way to look at our food. Ironically, LCA shows that it is four times MORE energy efficient for Londoners to dine on grass fed lamb from New Zealand than locally. Though it seems incomprehensible, the comparative advantage of growing lamb on the other side of the world outweighs the fuel and transportation costs of shipping it to London.
And lamb isn't the only product that falls into this category.
Localism is not always the most environmentally sound solution if more emissions are generated at other stages of the product life cycle.
Stirring up an organic panic
Here's a news flash: organic practices can't feed the world. It's all basic math. Scientific studies consistently produce lower yields between 25 and 82 percent. Therefore, to produce enough food, farmers would need that much more land to sustain current production levels.
The underlying temper of our times is that anything processed or industrialized can be seen as adulterated and harmful, while anything that appears to be natural or close to nature can be regarded as pure and uncorrupted. The reality of contemporary food production, whether organic or conventional, whether large-scale or small, stubbornly fails to follow this purified/corrupted script.
The author lists several "organic" practices, one of which the use of sodium nitrate. This product, mined in South America, is considered natural and is used to grow winter vegetables in dry soil. Used as a soluble fertilizer to enhance the soil's nitrogen content, organic farmers seem oblivious to the mining and shipping costs to the environment, the groundwater pollution sodium nitrate causes (artificially beefs up the nitrogen and phosphorous in soil), as well as its detrimental effects on soil salinization. Still, it's "natural."
A judicious use
McWilliams impressed me. Although he and I disagree about the causes of global warming (or the lack of global warming), I was impressed by his willingness to search for the truth, even if it didn't fit his version of reality. That's the mark of a real journalist. He ended the book with several very good conclusions:
- Go beyond food miles
- Go beyond organic and conventional methods
- Judiciously use biotechnology
- Judiciously use chemicals
- Reduce tillage
- Integrate livestock and plant crops
- Explore more freshwater aquaculture
We have a lot of people to feed. Just Food is a great way to point us in the right direction.
Buy or don't buy?
If you're concerned about the environmental effects the production of your food is having on our world, you'll enjoy reading Just Food. I've never been that concerned myself, but I still enjoyed reading it anyway, mostly because I felt that the author was real, honest, and willing to change his way of thinking if the facts presented themselves accordingly.
If you would like to win my copy (which I received free from the publisher – thank you Little, Brown & Company), just leave a comment on this post.
Note: I received this book gratis from the publisher.


text:
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More words related to fabricate
verb. construct structure
verb. create writing, artwork, or music
verb. assemble, build
verb. make deceitful imitation
verb. develop in mind or physically
- actualize
- author
- beget
- bring into being
- bring into existence
- bring to pass
- build
- cause to be
- coin
- compose
- conceive
Roget's 21st Century Thesaurus, Third Edition Copyright © 2013 by the Philip Lief Group.Cite This Source


text:
Mon Dec 24, 2012, 07:06 PM
cal04 (41,476 posts)
Ga. judge temporarily blocks abortion law
Source: AP
A state judge has temporarily suspended a Georgia law that would ban abortions for women who are more than 20 weeks pregnant.
The General Assembly passed the law earlier this year and it was set to take effect Jan. 1. Fulton County Superior Court Judge Doris Downs blocked the law in a Friday order as part of a challenge by the American Civil Liberties Union of Georgia.
Downs will rule later on the merits of the ACLU's challenge.
The law bans doctors from performing abortions five months after an egg is fertilized, except when they decide a fetus has a defect so severe it is unlikely to live. The law also makes an exception to protect the life or health of the mother, though that does not apply to a mother's mental health.
Read more: http://www.stamfordadvocate.com/news/article/Ga-judge-temporarily-blocks-abortion-law-4144146.php
6 replies, 2014 views
Always highlight: 10 newest replies | Replies posted after I mark a forum
Replies to this discussion thread
|6 replies
Ga. judge temporarily blocks abortion law (Original post)
|Dec 2012
|Dec 2012
|Dec 2012
|Dec 2012
|Dec 2012
|Dec 2012
|Spider Jerusalem
|Dec 2012
Response to cal04 (Original post)
Mon Dec 24, 2012, 07:26 PM
musical_soul (775 posts)
1. What would be wrong with this law?
The only thing I can see wrong with it is that it allows an exception for birth defects. The only exception should be life endangerment.
We're not talking about a fertilized egg or even an early pregnancy. We're talking about a fetus/baby that has arms, legs, heart, and a developing brain. This should not be allowed on demand.
Response to musical_soul (Reply #1)
Mon Dec 24, 2012, 08:41 PM
starroute (12,977 posts)
3. It creates a real problem with amniocentesis
The procedure can't be performed before the 16th week without risks to the fetus, and it takes 2-3 weeks for the results to come back. This law doesn't give much time to make the heartbreaking decision about whether to go ahead with an abortion and then schedule it.
Response to musical_soul (Reply #1)
Mon Dec 24, 2012, 09:59 PM
Humanist_Activist (6,829 posts)
4. What the fuck? So women should be forced to carry fetuses that can never survive outside...
their womb because of your infantile beliefs?
ON EDIT: On further examination of your post is even worse, what about the woman's health? Does that matter at all to you outside of her being just healthy enough to be an incubator, because it sure doesn't seem like it.
Response to musical_soul (Reply #1)
Mon Dec 24, 2012, 10:00 PM
Politicub (7,414 posts)
5. It's not your business or choice to make
It's up to the mother and the mother alone.
Response to musical_soul (Reply #1)
Tue Dec 25, 2012, 12:12 AM
Zoeisright (8,339 posts)
6. How about it's none of your fucking business?
The decision is between a woman and her doctor. YOU have NOTHING to do with it.
Response to cal04 (Original post)
Mon Dec 24, 2012, 07:47 PM
Spider Jerusalem (20,070 posts)
2. While I support the right of a woman to terminate a pregnancy if she so chooses...
I think it's also useful to remember that even a 20-week gestational limit for abortion would make the Georgia law one of the most liberal in the world. The time limit in most of Europe is 12 weeks. However it's also useful to note that the American Medical Association and the UK's Royal College of Obstetricians and Gynaecologists have both found that there's no scientific or medical basis for lowering the time limit before 24 weeks (as even at 24 weeks, foetal viability is less than 50%).


text:
Monday 22 June 1903
It was Monday, under the sign of Cancer. The US president was Theodore Roosevelt (Republican).
Famous people born on this day include John Dillinger and Carl Hubbell.
But much more happened that day: find out below..
You can also have a look at the whole 1903 or at June 22 across the years.
Old Newspapers
Have a look at the old newspapers from 22 June 1903 and get them!
Which were the most popular movies released in the last months ?
Find out your future
Get a FREE Numerology report based on the digits of 22 June 1903!
Wish him/her..
Historical Events
Which were the important events of 22 June 1903 ?
Famous Birthdays:
- John Dillinger: American gangster whose robberies and daring escapes during 1933-34 made him the most famous of all U.S.
- Carl Hubbell: Pitcher (New York Giants) - 253 wins, 2.97 lifetime ERA.
Famous Deaths:
- George White: Black resident of Delaware, lynched.
Music Charts
Which were the top hits in that special week of June 1903 ?
Top #1 songs in the USA
- There's a Lot of Things You Never Learn at School - Dan Quinn
Search For Your Ancestors
Subscribe to our Newsletter
Don't miss our monthly news, no spam guarantee Click here to Subscribe
...and if 22 June 1903 was your Birth Date then Join our Birthday Club!
Make this date unforgettable
Genealogy: find out your family heritage
Magazine Covers
What news were making the headlines those days in June 1903?
Which were the most popular books released in the last weeks ?
Remember when
What videogames would you be playing back in the days ?


text:
Has anyone sold their property privately?
What are the pro's and con's of selling privately with no estate agent involved?
Asked on Jun 22 2009, Selling in Gillingham | Report content
Answers (5)
Sort by: Oldest | Recent | Highest rated
There is huge debate about whether it ever pays off. You might avoid a few thousand £'s of agent commissions, but lose more thousands in what they might do to drive the price up by knowing (or attracting) more buyers than you can ever hope to privately. Never rule it out - but there's plenty of evidence that the annoying stuff you have to get through (HIPs, etc) can be more profitably done with an agent rather than going solo. If marketing and negotiation (and showing people round) are things you love doing then go for it. If you think that it's worth outsourcing this stuff then agents are the answer. I've always found that it makes sense to get an expert onto it because I'm crap at it - plus it feels like it makes more money doing it the easy way.Answered on Jun 24 2009, Report content
I sold my last home privately, you need to be in a area where property is in demand or it will be like flogging a dead horse.Answered on Jul 2 2009, Report content
Hi I live in Scotland and sold my house a few years ago. I did away with estate agents fees by putting an ad in the paper. Estate agents fee were the largest costs for them doing nothing, I felt. In Scotland we still have to go to a solicitor to complete the sale but it did save a lot of money. Hope this helps youAnswered on Jul 31 2009, Report content
Have bought and sold 12 properties. Have never found and EXPERT within an ESTATE AGENCY yet. Despite having engaged Estate Agents in every transaction for considerable sums up to 2.5% None would have sold within a sensible timeframe, without our own personal marketing input. I'm currently in the course of buying--------you would not believe the number of Estate agents who send details without room dimensions, let alone the square area involved----Actually admitting during subsequent telephone conversations that "they haven't been taken" or by implication, likely to be-----How they term themselves Professional beggars belief.Answered on Sep 2 2009, Report content
Hardest part will be finding a decent agent. I'd go with a local independent firm and negotiate that you can sell your property privately at the same time as they do. If you find a buyer, you don't pay them a fee. Problem will be getting enough interest privately. I did a test between private advertising and just Rightmove alone and I didn't get a single enquiry from Tepilo etc. but had 8 viewings and got full asking for the property by what we normally do. Good luck whichever you choose.
Web reference: http://www.mrgreenhomes.co.ukAnswered on Jun 18 2010, Report content
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