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This is really the territory of my pals over at the Insider, but I couldn't resist. Especially after I wrote about some back-and-forth between Mike Shanahan and a reporter, concerning the state of the Redskins' offense, during last week's post-game press conference. This week, the same reporter challenged Shanahan about Alfred Morris's lack of involvement during the second half of the loss to the Giants.
(The running back, who entered the week third in the NFL in rushing yards, had two carries for 15 yards in the second half.)
Other Reporter: "We didn't see a lot of Alfred in the second half. Any reason for that?"
Shanahan: "Um. Not particularly. We had a number of three-and-outs. I think we had three three-and-outs, and one four- or five-and out. And then kind of got in a passing situation at the end."
Challenging Reporter: "Mike, Alfred Morris, I know he only had the 11 carries. You had a lot of running by your quarterback. Why not run maybe your running back, who has been playing pretty well the last couple weeks? Was there something strategically wise that sort of precipitated that? It seemed like you went away from him a little bit there."
Shanahan: "Well, he had 11 carries there at the end of the first half and you're averaging about a yard and a half a carry. That's one of the reasons why you probably go away from it a little bit more."
Challenging Reporter, later: "Again, back to Alfred. He'd only run for like a yard per carry. Coaches always say good running backs like him, they're gonna pop one. How do you get him to that point, where he works up a lather and then pops one if you go away from him, I guess is what I'm asking?"
Shanahan: "Well, that has to do with third downs. When you don't the opportunity to have a bunch of plays in that second half — like we didn't — you don't have the opportunity to run that many plays. We've talked about this a number of times, that you've got to make third downs. We didn't make many. In that second half, I think in the first drive even though we went 50-some yards, I think we had 30 yards in penalties. And then you get a couple of three plays and out, and there's a couple of situations where you have some penalties and you're in long yardage situations and you're trying to get first downs. So that's why you don't get the number of carries."


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Food Fight Embroidered Stickers
Made by Mokuyobi Threads
We love these awesome new embroidered Food fight stickers from US designer Mokuyobi.
A colourful doughnut, carton of milk and juicy burger compete for the prize in this Food FIght embroidered sticker trio.
As well as being brilliant stickers for laptops, notebooks and phone cases, the Mokuyobi embroidered stickers can also be sewn onto bags and clothing and worn like regular patches - they even go through the wash perfectly!
Doughtnut measures 5.5x4cm, Milk 4.5x5cm, and burger 5.5x7cm approx.Like it? Pin it!

subset: commoncrawl


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carrotsby Kociara
Available in 11 and 15 ounce sizes, our premium ceramic coffee mugs feature wrap-around art and large handles for easy gripping. Dishwasher and microwave safe, these cool coffee mugs will be your new favorite way to consume hot or cold beverages.
A delectable collection of flaming orange carrots nestled amongst fresh, leafy green, this is a charming yet striking design.
These wriggly, orange carrots look as though they've just burst free from the earth - fresh, crisp and delightfully full of flavour. Set ablaze, they are the main attraction, surrounded by leafy haloes of green that burst from their tops.
The teal backdrop, caught in glimpses beneath, adds a warmth and depth that makes the design so inviting. Darker carrots appear like shadows or holes left in the soil, giving the impression of being carried home in bunches from the market. They form an intriguing cross-over of pattern, adding curiosity to an otherwise simple, diagonal pattern.


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My daughter, Petra, climb her first mountain on August 28, 2012. She was three years and two weeks old.
Huaguoshan rises 626 meters above sea level near Lianyungang on the east coast of China. It was not a large mountain by any means, but as we stood below it gazing up at its pagoda, stupa, and temple dotted sides and peak that sat opaque in the sea haze it seemed high enough. It is, after all, the highest mountain in Jiangsu province and my daughter still has some pretty short legs.
Petra walked toward Huaguoshan confidently, holding hands with both her mother and I as we began ascending the stairs. This is China, and the entire path up to the summit would be covered in steps. Thousands and thousands of them. It is my impression that Petra did not know what she was in for.
After around a half hour she began whining. "I don't want to walk anymore," she wailed. The day seemed to be going as I would have expected it to: Petra being carried up the mountain. But after taking a quick break for a snack and carrying her around for a short time while she napped, she returned to walking with a new attitude.
I tried to explain why people climb mountains. Telling her that there would be an amazing view from the time. I wanted to make reaching the summing seem like a game, like something fun. To my surprise, she got into it. Petra began climbing and climbing with enthusiasm. This was something new — usually this kid whines and throws a fit from having to walk a half hour around town. In an instant she seemed to turn a corner in her development, in an instant she got the concept of mountain climbing.
She eventually grew tired. Real tired.
"My leg doesn't work anymore," she exclaimed at one point.
She was right. Her left food did look as though it was glued below a set of concrete steps. She reached down with both hands and pulled it unstuck and continued climbing. She kept going.
I was impressed.
Soon enough we were at the summit, and Petra and I climbed over a rock outcrop that lead to the very top. My daughter and I scampered over the boulders, hand in hand.
Petra climbed her first mountain.


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Hubert Aarts, a Managing Director and Co-Head for Listed Equities provides a Q3 overview and outlook for Impax Leaders Strategy. Watch it here
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This is certainly the day and age of technological advancements. There isn't much you can't do if you have a smartphone, tablet or MacBook...


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VIDEO: Season High Vault, Beam Scores Highlight Auburn Meet
Feb. 7, 2011
The University of Kentucky gymnastics team made some strides in its last meet against No. 22 Auburn, posting a season-high score on vault and getting two career-high performances on beam from freshman Audrey Harrison and senior Andrea Mitchell.
Below are videos from the meet with Auburn, including Kentucky's entire vault rotation and Harrison and Mitchell's beam routines. Mitchell would go on to the win the all-around competition, becoming the first UK gymnastics to do so on the road in the SEC since 2006.
Vault Video
Harrison, Mitchell on Beam


text:
Site Map
Click the categories above for more essays.
The Meaning of You
Your worth is rooted in eternity, or it is nothing at all.
Grass Huts and the Cosmos
Success at last in the search for intelligent life beyond Earth.
Forgotten Corner of YouTube
Carl Sagan's followers are greater in number and fervency than ever before. Many treat his words like holy writ and see him as the hope of the world. But there is a better Hope.
Is God a Nice Person?
We have an all-powerful Friend who loves us, but bad things still happen. How can that be?
Christians Hurt, Too
Knowing why pain exists does little to abate the frustration and exhaustion that accompany it. But God provides the greatest possible answer to the question of pain.
Sale of College Property
Exchanging things precious for the fleeting and profane.
Tribute to a Pastor and His Wife
Christians live in grace, but often find it difficult to grant grace to our spiritual leaders. Let us honor those to whom honor is due.
Henry Ford and the Story of the Universe
Many believe science has removed the need for God from the human understanding of existence. They're wrong about that. Here's why.
If you have any questions, would like to make a comment on what you have read, or want to inquire about Tom's availability to speak at your event, you may do so through the
Contact Page
We invite your comments.
Thanks for taking the time to read.
Click subject or description to go to full essay.
Copyright 2007-2015 Tom Gilbreath All Rights Reserved Worlwide.


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Indian skipper Mahendra Singh Dhoni believes Sri Lankan paceman Lasith Malinga was a key player for the hosts, with his unique slinging action who troubled the Indian batsmen and helped Sri Lanka go one up in the three Test match series.
"Whenever we had some kind of partnership going, the Sri Lankan bowlers came up with a beautiful delivery," Dhoni said.
"With Malinga and the kind of action he has, you can't really say you are set whenever he comes on to bowl. You have to start all over again. He normally brings the ball in, but in his match, he can take it away also, you can be in trouble." Dhoni added.
Sri Lanka won the match convincingly and lead the three Test match series 1-0.
Incidentally, Muttiah Muralitharan became the first bowler in the history of Test cricket to complete 800 wickets after he got the final wicket of Pragyan Ohja in the Indian second innings.
Muralitharan playing his final Test match was given a grand farewell after the match.


text:
Yes I am
I am in with my item KolYoumDeal – Mobile Coupons & Shopping App
JoshuaSprague said
abada saidSure! Go for it
What about Titanium Category ??
Awesome thank you
Can you please update the post including Titanium
What about Titanium Category ??
Hello ,
Any codecanyon author tried to using nodejs for realtime in his item ? and what about it for end user ?
We know normal users after purchasing item based on nodejs + php he can`t install nodejs or deal with it ?
What author will do in this point ?
Can author depend on any online hosting ?
Hello Everyone
My latest work ElSabbat – Woocommerce Titanium App approved 30 March and be listed as trending badge but i have sales 4 only
what can do to increase my sales ?
please give me your feedback
Member Since December 2009
Thanks varcolac1000 for your reply
what about The Sales ?


text:
TOWNSVILLE'S professional basketball franchise is known as the Crocs and it was the scene for a feeding frenzy of Crocodile proportions for Brisbane's midfielders in its NAB Challenge clash with Gold Coast.
After its 131-point pumping at the hands of the reigning premiers, where not a single Brisbane player cracked the ton or featured in the top 10 ranked players, Brent Moloney, Tom Rockliff, Jack Redden et al cashed in on a weakened Gold Coast.
In the absence of Gary Ablett, Michael Rischitelli, David Swallow and Jaeger O'Meara, Brisbane had five players score more than 100 with Redden finishing on 141 points, Rockliff 132, Dayne Zorko 111 and Moloney 109.
The ray of hope for the Suns was Harley Bennell whose 20 disposals and four goals combined for 110 SuperCoach points.
Bennell enjoyed some support from big man Tom Nicholls (81) who enjoyed a great contest with Matthew Leuenberger (92).
Brisbane youngster Ryan Lester ($374,500) had another solid game with 80 points to go with his team-high 98 against Hawthorn.
PLAYER (Brisbane in bold)
Jack Redden 141
Tom Rockliff 132
Dayne Zorko 111
Harley Bennell 110
Brent Moloney 109
Matthew Leuenberger 92
Pearce Hanley 87
Tom Nicholls 81
Ryan Lester 80
Danny Stanley 77
Ryan Harwood 77
Matt Shaw 76
Daniel Rich 76
Sam Mayes 73
Luke McGuane 73
Brandon Matera72
Joel Patfull 71
Tom Lynch 71
Jed Adcock 69
Jack Martin 69
Nick Robertson 66
Luke Russell 65
Jarrod Harbrow 65
Jackson Allen 65
Steven May 64
Jesse Lonergan 63
James Aish 63
Trent West 60
Clayton Beams 60
Mitchell Golby 58
Jordan Lisle 55
Michael Close 55
Joshua Green 54
Daniel Merrett 49
Karmichael Hunt 48
Charlie Dixon 48
Daniel Gorringe 48
Justin Clarke 48
Jeremy Taylor 48
Tom Murphy 46
Marco Paparone 45
Sam Day 43
Matthew Warnock 43
Jordon Bourke 37
Josh Hall 37
Alex Sexton 37
Sean Lemmens 37
Aaron Hall 35
Greg Broughton 34
Clay Cameron 29
Tom Cutler 27
Timmy Sumner 24
Originally published as SuperCoach scores: Lions v Suns


text:
- Duration
70 minutes.
- Group Size
Minimum of 10 hens.
- Availability
7 days a week.
- Seasonal
All year round.
- Dress Code
An extra layer to keep out the chills...
- Location
Central Brighton.
Please note...
Please Note: This page provides a general guide to our ghost tour in Brighton. We work with multiple suppliers, so please be aware that specifics may vary. Feel free to ask your Destination Specialist at the time of booking if you have any questions about this.


text:
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It only takes a minute to get started. Fill out our simple sign up form and login to the site.
This step is discretionary but will seriously increase your chances of getting interest from other over 50s members on the site. Write a little about yourself, your hobbies and upload a nice photograph of yourself.
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ActiveDen Bowling 65528
Flash Templates \ Animations \ Animated Objects
Flash Template - Bowling 65528 by hronus @ ActiveDen
Flash Templates \ Animations \ Animated Objects
ActionScript Version: AS2; Documentation: Well Documented; Flash Files Included: Flash FLA; Opens With: Flash 8 (8+) Published Size: 17.9kb
Animation strike in bowling. AS2 . Easily drag and drop into any project. Very simple code. Enough even entry-level knowledge of the script.You can customize the color of illumination. All colors are configured in one place! Ideal for use in creating banners and animations similar subjects. 100% vector!
Key Words: animation, blue, bowling, green, kegling, kegling, of, red, simple, yellow.
Download Link


text: The Force Mystic Gear Set is an adaptive armor set available from the Cartel Market. Battlemaster Champion Centurion1 of 3Add photo Retrieved from "http://swtor.wikia.com/wiki/Force_Mystic_Gear_Set?oldid=95117" Ad blocker interference detected! Wikia is a free-to-use site that makes money from advertising. We have a modified experience for viewers using ad blockers Wikia is not accessible if you've made further modifications. Remove the custom ad blocker rule(s) and the page will load as expected. Categories: Armor PvP Armor Set Sith Sorcerers Light Armor Armors Article Stubs


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Conrad Murray, the doctor convicted of killing Michael Jackson, was released early Monday morning (Oct. 28) after serving nearly two years of his four year sentence.
The Associated Press reports the former cardiologist was sent home from a downtown Los Angeles jail just after midnight. His sentence was cut short due to a change in California law that aims to ease overcrowding.
Murray was convicted of involuntary manslaughter in 2011 for Jackson's June 2009 death from an overdose of the powerful anesthetic propofol. The late star had been taking the substance as a sleeping aid as he prepared for a series of comeback concerts titled "This Is It."
Murray's license has since been suspended or revoked in three states and he is infamously known as the doctor who killed the King of Pop.
Murray is in the process of appealing his conviction in hopes to clear his name from the tragic incident.


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InsidetheOs: Tell us what it feels like to be selected by the Orioles?
Adam Davis: I feel relieved that it happened. I knew I could do it but all the weight of the draft is off my shoulders and I can start pro baseball.
ITO: Talk about your game a little bit. What type of player are you and how do you see yourself fitting in with the Orioles?
Davis: I swing the bat pretty well although I am more of a doubles guy. Defensively I have a strong arm I like to block balls. I am Not afraid to get hit or get ran over. Pretty aggressive call own game.
ITO: What are your strengths and your weaknesses?
Davis: My strength is that I am athletic for a catcher. I stole 15-20 bases. I wouldn't say it is a weakness but just understanding the catcher position at the pro level.
ITO: Who would you compare your game to at the Major League level so the Orioles' fans have an idea of what your game is like?
Davis: I love the way Buster Posey played last year. He is aggressive, hits well and has a good arm. A catcher has to be a leader on and off the field.
ITO: Were you expecting to be drafted by the Orioles or were you surprised they selected you?
Davis: The Orioles were one of my top five teams; had a couple meetings with them. I Thought it was going to be anywhere in the fourth through seventh round. I got a call from the O's guy and he told me they were going to draft me. It is an amazing feeling and I cant wait to get started.
ITO: What would you say is your best moment in baseball and why?
Davis: This past week in big ten tournament and we won the tourney. I got MVP of the tournament and I am proud of that because we have great players on this team and conference. We knocked out Cal-State Fullerton and we lost to Stanford.
ITO: Who was your favorite team and player growing up?
Davis: White Sox because I am from Chicago and wanted to go different because most everybody I was around were Cubs fans.
ITO: Are you planning on signing right away or will this be a process?
Davis: I am not going to wait the whole summer. I plan to sign right away just need some time to rest. Not really about money I just want to play.


text:
Cross Cultural Psychology Items77 textbooks were found
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Cognition and Culture, Volume 103: A Cross-Cultural Approach to Cognitive Psychology (Advances in Psychology)RentList Price:$72.95
Cross-Cultural and National Studies in Social Psychology: (Proceedings of the XXIII International Congress of Psychology)List Price:$114.50
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Psychological Selection and Optimal Experience Across Cultures: Social Empowerment through Personal Growth (Cross-Cultural Advancements in Positive Psychology)RentList Price:$269.00
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|Named Person:
|Henry L Abbot; David Bushnell; Ezra Lee; Edward Schieffelin; Henry L Abbot; David Bushnell; Ezra Lee; Edward Schieffelin
|Document Type:
|Archival Material
|All Authors / Contributors:
David Bushnell
|OCLC Number:
|.25 linear ft. (1 box)
|More information:
Miscellanious papers by and about Bushnell. Only two items are in his hand: a letter(1787) claiming land due him as a result of his service in the American Revolution, and a description of a model for a sailing torpedo [1824?]. Papers on his inventions include a letter by Ezra Lee (1815) with an account of Bushnell's submarine and Lee's operation of it in August, 1787 in New York harbor. Also three letters by Joel Abbot (1825)to Bushnell (then known as David Bush) on his attempts to promote Bushnell's naval warning device. Correspondence (1826-1827) between his executor and his heirs, Ezra and Nehemiah Bushnell of Saybrook, Connecticut, includes a final accounting of Bushnell's estate. In the later papers (1881-1956) are four letters to Anson Phelps Stokes with biographical information on Bushnell and publications on his submarine.
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text:
Imolian butter is a foodstuff, a type of butter.
In the year 2374, Benjamin Sisko used Imolian butter while making an omelette. (DS9 - Millennium novel: The Fall of Terok Nor)
- It was not referred to whether "Imolian" refers to a locational origin, a cultural origin, or a description of the style of which this substance was made.


text:
Small-molecule and mutational analysis of allosteric Eg5 inhibition by monastrol
A recent crystal structure of monastrol in a ternary complex with the kinesin Eg5 motor domain highlights a novel, induced-fit drug binding site at atomic resolution. Mutational obliteration of the monastrol binding site results in a monastrol-resistant, but otherwise catalytically active Eg5 motor domain. However, considering the conformational changes at this site, it is unclear what specific interactions stabilize the interaction between monastrol and the Eg5 motor domain.
To study the molecular complementarity of the monastrol-Eg5 interaction, we used a combination of synthetic chemistry and targeted mutations in Eg5 to measure the contribution of specific contacts to inhibition of Eg5 in vitro and in cultured cells. Structure-activity data on chemical derivatives, sequence analysis of Eg5 homologs from different species, and the effect of mutations near the drug binding site were consistent with the crystal structure.
The mechanism of monastrol revealed by our data rationalizes its specificity for Eg5 over other kinesins and highlights a potential mechanism of drug resistance for anti-cancer therapy targeting this site in Eg5.
Kinesins are a diverse family of microtubule-based motor proteins important for intracellular transport and cell division in all eukaryotes
BimC class kinesins are widely required for bipolar spindle assembly during mitosis and meiosis. They are homotetrameric, plus-end directed kinesins that associate with the spindle during mitosis
The co-crystal structure of Eg5 bound to monastrol reveals the drug binding site in atomic detail. Monastrol binds in a hydrophobic, induced-fit pocket between two non-conserved features of kinesin motor domains, loop 5 and alpha-helix 3 (α3) (Figure
Figure 1
Ternary complex of Eg5 motor domain with monastrol and ADP-Magnesium
Ternary complex of Eg5 motor domain with monastrol and ADP-Magnesium. Ternary complex of Eg5 motor domain with monastrol and ADP-Magnesium. (A) Ribbon diagram of the Eg5 motor domain (pale blue) with the nucleotide binding site facing down, containing ADP-Magnesium (adapted from PDB: 1Q0B). Monastrol is bound 12 Å from the nucleotide binding pocket, in a pocket formed by residues in α2 (green, labeled 'a2'), α3 (yellow, labeled 'a3') and loop 5 (red), a structural feature interrupting α2. (B) Stereoscopic view of monastrol binding site to illustrate the hydrophobic dihydropyrimidine binding surface between α2 and α3 formed primarily by the side chains of amino acid residues E116, I136, P137, Y211, L214, and A218. The van der Waals contact surface of Eg5 is labeled with its corresponding amino acid residue and is colored gray for carbon, red for oxygen, and blue for nitrogen. (C) The hydroxyphenyl ring is oriented perpendicular to the plane of the dihydropyrimidine ring in a hydrophobic pocket bounded by the side chains of amino acid residues R119, W127, A133, and Y211. Two potential hydrogen bonding interactions between monastrol and the backbone carbonyls oxygens of amino acid residues E116 and E118 are highlighted in red. Distances from monastrol N to E116 and O to E118 are 2.82 Å and 2.73 Å, respectively.
Guided by the atomic structure of the Eg5-ADP-monastrol ternary complex, we used a combination of synthetic chemistry, targeted mutagenesis, and protein biochemistry to characterize the interaction between the Eg5 motor domain and monastrol at the atomic level. Initially, we confirm that the structure is consistent with species-specificity of monastrol in cells. A structure-activity relationship for monastrol and mutation of target binding residues tests the importance of individual amino acid residues and chemical substituents to the protein-drug interaction.
Confirmation of crystal structure
We crystallized the monastrol-ADP-Eg5 motor complex, and solved its structure, independent of the published work
Additional File 1
Atomic structure determination of the Eg5-monastrol-ADP complex using multi-wavelength anomalous dispersion (PDB 1X88). Materials and methods for determination of Eg5-monastrol-ADP co-crystal structure using selenomethionine-labeled Eg5 motor domain as independent verification of published structure
Click here for file
Additional File 2
Crystallographic data and refinement statistics for structure of Eg5-monastrol-ADP complex (PDB: 1X88).
Click here for file
Structure-activity relationship of monastrol derivatives
We synthesized a variety of monastrol derivatives using the Biginelli cyclo-condensation (Figure
Figure 2
Structure-activity relationship of monastrol derivatives
Structure-activity relationship of monastrol derivatives. (A) Scheme depicting the Biginelli condensation, a one-pot reaction for preparing monastrol derivatives [40]. (B) Monastrol (circles), but not derivative 2 (squares), inhibits ATP hydrolysis by 500 nM hEg5-367H in KC25 buffer supplemented with 1 mM ATP-KOH (pH 7.0). The IC50 for monastrol is 5.2 +/- 0.4 μM. Each data point is the average of three independent experiments. (C) Summary of SAR results for monastrol derivatives inhibiting the catalytic activity of the Eg5 motor domain and inducing monoaster formation in tissue culture cells, as described [28]. IC50 for each inhibitor was measured as described in part B. In cell-based assays, the potency of each derivative was obtained by treating BS-C-1 cells as described in the methods section, and manually counting mitotic cells to yield a score as follows: the drug concentration with roughly equal monastral and bipolar spindles, of < 50 μM (+++), weak compounds 50 to 200 μM (+ or ++), and inactive (-) compounds displayed no effect at 200 μM. Each cell-based assay was performed in duplicate.
Monastrol is specific for vertebrate Eg5 homologs
Monastrol binds a hydrophobic pocket between loop 5 and α3 that is poorly conserved among kinesins, resulting in specificity for vertebrate Eg5 homologs. The amino acid side chains that contact monastrol are conserved in human Eg5 and its homologs from
Figure 3
Sequence requirements for monastrol binding to Eg5
Sequence requirements for monastrol binding to Eg5. (A) Amino acid sequence alignment of residues near the monastrol binding site in Eg5 homologs from
Mutational analysis of monastrol binding site
To further test the sequence requirements for monastrol binding and specificity, we introduced mutations into the motor domain of human Eg5. The mutations replaced amino acid residues lining the monastrol-binding pocket with the corresponding residues from human conventional kinesin (Figure
Figure 4
Mutagenesis of the monastrol binding site in human Eg5
Mutagenesis of the monastrol binding site in human Eg5. (A) Design of mutations in the human Eg5 motor domain. Amino acid side chains that are not conserved between Eg5 and conventional kinesin were targeted, either introducing chimeric or rationally designed mutations (asterix for targeted point mutants) to test the contribution of residues to the drug-sensitivity of Eg5. (B) Steady-state enzymatic parameters for engineered human Eg5 motor domain mutants. Steady-state ATP hydrolysis by Eg5 was measured using an NADH-enzyme coupled assay varying the concentration of ATP, microtubules, or monastrol to obtain the microtubule concentration for half-maximal stimulation (K0.5MT), the maximal rate of microtubule-stimulated ATP hydrolysis (kcat), and the concentration of monastrol that inhibits basal ATP hydrolysis by 50 % (IC50), as described [28].
All of the point-mutants, with the exception of Y211M, decreased the drug sensitivity of Eg5. Y211M actually increased the monastrol sensitivity of Eg5, perhaps because flexibility of the methionine side chain accommodates a more favorable hydrophobic interaction with the drug. Hydrophobic packing between the thiourea and L214 appears to be crucial for drug binding, illustrated by the dramatic effect of even a subtle L214I mutation on IC50. L214T mutant was resistant to monastrol, as would be expected, but also to derivative 2 (data not shown) with a compensating hydrophilic urea. Hydrophobic contacts from R119 are required for monastrol binding, but electrostatic interactions also appear important (Figure
Monastrol is a convenient reagent for mitosis research, but its specificity hitherto has not been established. Experiments designed to probe the role of Eg5 in the mitotic spindle and post-mitotic neurons are predicated on the assumption that monastrol is a specific inhibitor of Eg5
Monastrol binds a cryptic site that would not have been discovered by virtual screening methods previously employed to find novel small-molecule kinesin inhibitors
Although mutations at this site permit microtubule-stimulated ATP hydrolysis by the motor domain of Eg5, their effect on the kinetic parameters KmATP, K0.5MT, kcat, and IC50 indicate subtle effects on its catalytic cycle. Monastrol decreases the microtubule affinity of Eg5, and one might expect mutations that lower K0.5MT to raise IC50 for monastrol. This may be true for the L214I, a subtle mutation that would effect transitions between ordered and disordered states of α3
The monastrol binding site is a promising target for anti-cancer drug development, but our data showing that relatively subtle mutation confer resistance to drug binding without blocking enzymatic function sound a note of caution; Eg5 has potential for sporadic mutation to result in clinical resistance. Pressure to conserve residues at a substrate binding pocket is one explanation for the selectivity of non-competitive inhibitors among related proteins as compared to substrate-competitive inhibitors
The published crystal structure of monastrol in a ternary complex with the Eg5 motor domain and ADP
Reagents were obtained from Sigma-Aldrich, unless otherwise indicated. Experimental stocks of taxol (10 mM), PMSF (100 mM), benzimidine hydrochloride (200 mM), 1000 × LPC (10 mg/ml each of leupeptin, pepstatin, and chymostatin), and monastrol derivatives (200 mM) were prepared as DMSO solutions, aliquoted, and stored at -20°C until use. KC25, the standard buffer used in biochemical experiments described below consists of 20 mM PIPES-KOH (pH 6.8), 25 mM KCl. All tissue culture media were supplemented with heat inactivated fetal calf serum (HyClone), penicillin and streptomycin (Cellgro, Mediatech).
Structural analysis of Eg5-monastrol-ADP complex
We determined the atomic structure of the Eg5-ADP-monastrol complex using multi-wavelength anomalous dispersion to a resolution of 1.80 Å. Although our protein crystals grew under different precipitant conditions than those described by Yan and colleagues, the atomic structure of the Eg5 motor domain were essentially identical to the published results
Tissue culture assays
Conditions for growing the following cell lines are as described:
Cloning, purification, and characterization of Klp-61F motor domain
The motor domain from
Synthesis of monastrol derivatives
Monastrol derivatives were synthesized via the Biginelli condensation, purified by silica-gel chromatography, and characterized by 1H-NMR and tandem liquid chromatography/electrospray ionization mass spectrometry, as described
Preparation of Eg5 motor domain mutants
We used a modified PCR mutagenesis protocol
Measurement of ATP hydrolysis kinetics
ATP hydrolysis by recombinantly expressed kinesin motor domains was measured using an NADH-enzyme coupled assay
ATP: Adenosine 5'- triphosphate
ADP: Adenosine 5'-diphosphate
DMSO: Dimethyl sulfoxide
LPC: Mixture of leupeptin, pepstatin, and chymostatin
MT: Microtubule
NADH: Beta-Nicotinamide adenine dinucleotide, reduced
NNRTI: Non-nucleotide reverse transcriptase inhibitor
PDB: Protein database
PIPES: Piperazine-1,4-bis(2-ethanesulfonic acid)
PMSF: Phenyl methyl sulfonyl fluoride
SAR: Structure activity relationship
SiRNA: Small inhibitory Ribonucleic Acid
TCEP: Tris (2-carboxyethyl) phosphine
Authors' contributions
The corresponding author performed all experiments.
Members of the Institute for Chemistry and Cell Biology and Mitchison laboratories provided thoughtful review of the manuscript. Dr. Barry H. Paw provided
Antagonistic microtubule-sliding motors position mitotic centrosomes in Drosophila early embryos
The molecular motor toolbox for intracellular transport
Targeted disruption of mouse conventional kinesin heavy chain, kif5B, results in abnormal perinuclear clustering of mitochondria
Cargo of kinesin identified as JIP scaffolding proteins and associated signaling molecules
A novel motor, KIF13A, transports mannose-6-phosphate receptor to plasma membrane through direct interaction with AP-1 complex
The roles of microtubule-based motor proteins in mitosis: comprehensive RNAi analysis in the Drosophila S2 cell line
Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen
Dissecting temporal and spatial control of cytokinesis with a myosin II inhibitor
Probing spindle assembly mechanisms with monastrol, a small molecule inhibitor of the mitotic kinesin, Eg5
Eg5 is static in bipolar spindles relative to tubulin: evidence for a static spindle matrix
Antitumor activity of a kinesin inhibitor
Kinesin spindle protein (KSP) inhibitors. Part 1: the discovery of 3,5-diaryl-4,5-dihydropyrazoles as potent and selective inhibitors of the mitotic kinesin KSP
Induction of apoptosis by an inhibitor of the mitotic kinesin KSP requires both activation of the spindle assembly checkpoint and mitotic slippage
A "slow" homotetrameric kinesin-related motor protein purified from Drosophila embryos
Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo
Mitotic spindle organization by a plus-end-directed microtubule motor
Mutations in the kinesin-like protein Eg5 disrupting localization to the mitotic spindle
Mutation of a gene that encodes a kinesin-like protein blocks nuclear division in A. nidulans
The kinesin-related protein, HSET, opposes the activity of Eg5 and cross-links microtubules in the mammalian mitotic spindle
Computer simulations reveal motor properties generating stable antiparallel microtubule interactions
The bipolar mitotic kinesin Eg5 moves on both microtubules that it crosslinks
The kinesin Eg5 drives poleward microtubule flux in Xenopus laevis egg extract spindles
Monastrol inhibition of the mitotic kinesin Eg5
Monastrol stabilises an attached low-friction mode of Eg5
Inhibition of a mitotic motor protein: where, how, and conformational consequences
Identification of the protein binding region of S-trityl-L-cysteine, a new potent inhibitor of the mitotic kinesin Eg5
Interaction of the mitotic inhibitor monastrol with human kinesin Eg5
Evidence that monastrol is an allosteric inhibitor of the mitotic kinesin Eg5
Monastrol, a prototype anti-cancer drug that inhibits a mitotic kinesin, induces rapid bursts of axonal outgrowth from cultured postmitotic neurons
Monastrol, a selective inhibitor of the mitotic kinesin Eg5, induces a distinctive growth profile of dendrites and axons in primary cortical neuron cultures
Inhibitors of kinesin activity from structure-based computer screening
Development and biological evaluation of potent and specific inhibitors of mitotic Kinesin Eg5
Allosteric drugs: thinking outside the active-site box
Unique features in the structure of the complex between HIV-1 reverse transcriptase and the bis(heteroaryl)piperazine (BHAP) U-90152 explain resistance mutations for this nonnucleoside inhibitor
RNA interference rescue by bacterial artificial chromosome transgenesis in mammalian tissue culture cells
Zebrafish mitotic kinesin-like protein 1 (Mklp1) functions in embryonic cytokinesis
Parallel chemical genetic and genome-wide RNAi screens identify cytokinesis inhibitors and targets
Two-stage PCR protocol allowing introduction of multiple mutations, deletions and insertions using QuikChange Site-Directed Mutagenesis
Recent advances in the Biginelli dihydropyrimidine synthesis. New tricks from an old dog


text: To get from Santa Maria Capua Vetere to Trieste by train you can catch one of the 8 trains that everyday travel between these two cities. The first train to Trieste leaves from Santa Maria Capua Vetere at 05:08 and the last train departs at 15:13. If you choose a local train the trip lasts on average 08:06 hours. For your trip from Santa Maria Capua Vetere to Trieste by train you can choose to leave from one of Santa Maria Capua Vetere main stations: S. Maria Capua Vetere On Wanderio you can compare all schedules, fares and railway companies to Trieste and book the best itinerary starting from Santa Maria Capua Vetere.


text:
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text:
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text:
"Who are you?"
The title of this article is conjectural. Although this article is based on canonical information, the actual name of this subject is pure conjecture. Please see the reasons for this title in the "Behind the scenes" section below, and/or the relevant discussion on the talk page.
The temple keeper was first encountered by Indiana Jones in the mid-1930s. He requested that Jones return the Mayan Stele the archaeologist was looking for to its pyramid, which he did.


text:
|Message view
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|« Date » · « Thread »
|Re: cvs commit: httpd-2.0/server/mpm/perchild perchild.c
|Sun, 06 May 2001 23:29:24 GMT
> Back out the recent change to ap_get_brigade, to make it use indirection > again. The problem is that the amount of data read from the network, > is not necessarily the amount of data returned from the filters. It is > possible for input filters to add bytes to the data read from the network. > > To fix the original bug, I just removed the line from ap_get_client_block > that decremented r->remaining, we allow the http_filter to do that for > us. > > I have also removed an incorrect comment. I meant to comment that I had POST'ed a 6 Meg file as my test. Ryan _______________________________________________________________________________ Ryan Bloom email@example.com 406 29th St. San Francisco, CA 94131 -------------------------------------------------------------------------------
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text:
You can only message people who are following you. If you'd like to message this person, simply join our Recruiter Pro Plan.
motivated marketing graduate, looking for the next challenge in a marketing, events, PR, advertising and/or media-related sectorLocked Pro Plan feature
Creating a variety of different types of content (newsletters, press releases, website content, social media posts etc.).
Selling telecommunication- and entertainment-related products to customers via telephone, according to their needs.


text:
A new way in.
The Literary Portals to Prayer series is the first truly new resource for personal prayer in years. Designed to be a prayer-starter in the "Lectio Divina" tradition, these books have a passage from the Bible side-by-side with a selection from an author whose work has stood the test of time. Each turn of the page ties together literature and scripture with an insightful theme.


text:
To sell a unique and spacious private residence in Pirita-Kose, on an elite street, Särgava alley. The land has a downward relief. The house is built into a mountain: looking from the street, the house is two stories, from courtyard, one storey. The I floor is built of Fibo block, interior construction is unfinished. Heated floors. According to the house plan, the first floor can be used as a pool hall with a fireplace, or as a winter garden. A room that can be built into a sauna. At the moment, on the I floor, there are 2 big halls, 1 room, a sauna, a heating room, and a hallway. (I floor 130m2.) II floor is built of log. There are spacious rooms: a big living room with a high ceiling and a fireplace, a bedroom with very interesting light design elements is built into the floor, a bathroom with a bubble bath, a sauna, 2 children's rooms, a kitchen (oak furniture), a small office. (II floor 180m2). Natural wood flooring in the rooms, tiled floors in the kitchen and bathroom. Heating: at the moment the most economic air source heat pump (dec. 2016 the eletrical bill ca 250€, in the summer 70€). Possible to use ion heating (in all the II floor rooms are radiators). Additonal option for warmth with heating the fireplace. A car shelter for 3 cars. The house foundation is protected from humidity and properly insulated. The windows are made of wood and aluminum. I will help you with selling, renting, and buying real estate, applying for loans and appraisal reports. Correct contracts and professional transactions. Free consultation!
|Property type:
|Total area:
|280 m²
|Construction year:
|Direct reference:
|Price / m²:
|Monthly payment of this property in SEB bank:
|Send request for credit consultation
|Kindlustusmakse ERGOs:
|80 EURUuri täpsemalt
|Cadaster number:
|Building material:
|log house
|tin plate
|Heating system:
|electric heating, fireplace, air-source heat pump
|Energy certificate:
|no certificate
|Ownership rights:
|immovable property
|new building
|Number of rooms:
|Number of bedrooms:
|Number of bathrooms:
|Total area:
|280 m²
|Plot size:
|895 m²
|Total floors:
|designated parking on property
|digi-tv, internet
|neighbourhood watch
|Sanitary arrangements:
|sauna, bath, boiler, washing machine
|electric stove
|Extra values:
|closed yard, furnishing possible, industrial power supply, has refigerator
Kindlustuse kalkulaator
|€ /kuus
|Tegemist on näitliku kuise ERGO kindlustusmaksega. Riskidena on valitud tuli, vesi, torm ja vandalism. Elukoht on valitud alaline ning omavastutus 100€
|Calculate again
|Kindlustusest lähemalt
Keegi ei saa oma kodu 100% turvaliseks muuta, kuid riske on võimalik maandada. Jaga oma vastutust kindlustusseltsiga. See annab Sulle turvalisema olemise ja leevendab rahaliselt ettenägematust.
05 July, 11:40
Operating in all three Baltic States, premium real estate brokerage company Baltic Sotheby's International Realty opened the doors to their new office in ...
07 April, 10:14
There are many factors which affect the Estonian real estate market, from the number of properties available to the demand for them. An important element ...
06 February, 11:12
If you wish to let out or sell your apartment or find buyers for your private house, Baltic Sotheby`s International Realty will find appropriate tenants or ...
01 November, 14:32
Arco Vara AS and SIA Arco Real Estate (hereinafter "Company") management jointly announce management buyout (hereinafter "MBO") of the Company. On 31 October, ...
20 October, 14:52
On 14 October 2016, AS Harju Elekter signed a contract for the purchase of the real estate company Kiinteistö Oy Uutvallinkulma. Following the transaction, ...
27 September, 15:36
Concrete Association of Estonia and Association of Construction Material Producers of Estonia have announced the "Concrete Building of the Year 2016" ...


text:
Krabi, Thailand
Koh Phi Phi Don
Krabi, when first seen from the air, is a memorable experience. The perfect blend of blue sea, white beaches and green limestone karsts can be so visually stunning it mesmerizes you. The mysterious looking limestone islets both onshore and offshore are unique to a very few areas of the world.
Some of those green cloaked limestone towers flanked by dazzling white sand beaches form small idyllic islands. The azure translucency of the Andaman Sea invites you to luxuriate in its tropical waters and explore what lies beneath the surface.
Over centuries, the relentless ocean has torn away the limestone bit by bit, making many of the islands appear fragile and in danger of toppling into the deep. Beware of these deserted islands of Phang Nga Bay. You may leave these shards of paradise, but you can never forget them.
Krabi Attractions & Activities
Krabi's spectacular vistas are the primary attractions of the province, yet the province is a complete destination. You can relax on a stunning beach, explore one of the unique islands, tour the bay in sea kayaks, or climb the limestone face above Railay Beach.
Krabi also has a number of good @ scuba diving sites. Most notable are the @ dive sites around Koh Phi Phi and the southern island @ dive sites around Koh Lanta.
Both Railay Beach and Ko Phi Phi have @ rock climbing with bolted routes, equipment for rent, climbing schools and guides.
The area has a number of interesting caves. Some are revered as religious sites while others are nesting places for swallows.
Phang Nga Bay
The Phuket Sea stretches from the coastline of Phang Nga north of Phuket down the cost until it merges with the Andaman. The Andaman has hundreds, perhaps thousands, of these special islands. Many have yet to be explored.
Some of the islands have become famous and get an unappealing amount of tourist traffic. James Bond Island is a good example. Practically every tourist boat dock in Phang Nga has a James Bond Island tour.
Some of the less touristy islands offer unique opportunities. A couple or family can arrange a picnic lunch, hire a private boat and spend a day or an afternoon on their very own beach.
Railay Beach
Railay Beach has become a @ rock climber's dream. A towering limestone face soars above a tropical jungle while azure waters shimmer below and balmy trade winds urge every moment of the climb.
Railay Beach can only be reached by boat, which give it a special appeal. The area has continually developed with bungalows and resorts and presents a unique ambiance.
Ao Nang
Ao Nang is the beach center of the tourist area. The 2 km long stretch of sand is crowded and has far too many touts. But Ao Nang is the starting point for visiting other areas and has all tourist services available. Accommodations on Ao Nang range from modest guest houses to the splendor of Rayavadee resort.
Phra Nang
Phra Nang is the just up the coast from Ao Nang and less touristy. Phra Nang can be reached by long-tailed boat. The water is very calm as the beach is protected by surrounding cliffs.
Koh Phi Phi
Ko Phi Phi was once the stuff of dreams. The prototype paradise island has starred in movies and been the subject of millions of words. Countless thousands of travelers have departed the island with tears in their eyes. So elegantly carved from the sea, the emerald bays dusted with sugary sand, Koh Phi Phi is singularly beautiful.
But time, tourism and greed left a stain on the gem. One travel
forum poster said it well.
"I remember the first time we saw Phi Phi. We stood and cried at the beauty of the place. On our last visit, we cried at what tourism development has done to it."
Then along came the tsunami and returned the island to much of its original beauty. Most of the garbage was cleaned up. Koh Phi Phi still has beautiful areas. The island's appeal is quite a personal matter, see it yourself. It certainly is worth the boat ride.
Koh Lanta
Koh Lanta is a new paradise island destination that has developed rapidly. Koh Lanta Yai is the largest of a series of islands just offshore from the southern end of Krabi. Koh Lanta National Park is located on the southeastern shore of Koh Lanta Yai.
The Other Islands
Koh Ngai, Koh Rok Nok, Koh Rok Nai, Koh Poda, Koh Kai and Koh Hong are among the destination islands around Krabi.


text:
- Devise
- Devise De*vise", n. [OF. devise division, deliberation, wish,
will, testament. See {Device}.]
1. The act of giving or disposing of real estate by will; --
sometimes improperly applied to a bequest of personal
[1913 Webster]
2. A will or testament, conveying real estate; the clause of a will making a gift of real property. [1913 Webster]
Fines upon devises were still exacted. --Bancroft. [1913 Webster]
The Collaborative International Dictionary of English. 2000.


text:
257 Johnstown Center Drive, Johnstown, CO 80534Request info Add to list
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Convenience/Strip Center Newer building that is modern, clean and well landscaped.
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text:
When Copperas Cove lost in the area round, it left a pain.
When Gatesville lost three all-district players, it left a void.
When Lampasas lost its grip on an unexpected level of success, it left doubt.
More importantly, each team's 2011 season left it with something to prove.
Last season, with current Baylor freshman Amy Rosenbaum highlighting the squad, the Lady Bulldawgs produced a 33-win season, including a 12-2 run through district. But they were swept by eventual regional semifinalist Lake Highlands in the second round.
Despite the departure of Rosenbaum and a handful of other seniors, Copperas Cove has an experienced core returning, centered around eight upperclassmen.
The group, along with its coach, believes now is the time to create a legacy comparable to the school's two-time state finalist football team, and they are putting in extra work to help produce a deep playoff run.
"They never stop working at getting better at volleyball," Copperas Cove head coach Cari Lowery said of her players. "And that is really what it takes at a (Class) 5A school.
"Our football players are up here for strength and conditioning in the summer, and they are workingon being better football players all year long, and our volleyball players are doing the same."
Due to realignment, the Lady Bulldawgs now reside in District 8-5A with Belton, Killeen, Ellison, Shoemaker, Harker Heights, Temple and Waco Midway, but Arielle Garcia is showing no lack of confidence.
"Basically, I know that we can do it," the senior setter said. "We can definitely be the district champs."
Less than 20 miles away, the Lady Badgers enter the 2012 campaign looking to show themselves and their critics the program's brief brush with success was not a fluke.
One year after losing a playoff play-in match, Lampasas snapped a lengthy postseason absence in 2010, but following the departure of all-state selection Madison Morris for UTEP and head coach Beth Rutland for motherhood, the Lady Badgers spent a season in flux, searching for an identity.
With just three seniors on the roster, it is a problem Lampasas continues to struggle with.But if new coach Kecia Davis has her way, it will not take long before the Lady Badgers are molded into strong competitors both mentally and physically.
"I came in with a tough workout for them, and I'm big into weight lifting," the former UMHB coach said. "I have a particular program that I do that works on mental toughness, but it has a lot of conditioning included.
"I've been pretty pleased with their effort on that."
The results are already evident in outside hitter Jenna Jenkins.
"Even though we are a younger team, we can do things, and it is possible for us to go farther than we have in the past few years," the senior said.
Unlike Lampasas, Gatesville has become a perennial playoff participant under head coach Rickey Phillips, who has taken the Hornets to the postseason nine consecutive years with the most recent two ending at the regional tournament.
Although the team lost several key players from its 2011 roster, including unanimous district MVP Glynna Johnson, setter of the year Kaitlin Poe and blocker of the year Skye Truss, Phillips believes his current squad will find a way to continue the trend.
After all, they have a history to maintain.
"I think our kids kind of feel like they don't want to be the ones to let that streak end," the coach said. "It's their drive during the summer. It is what gets them to go play club ball when they can, and it gets them to go to camps.
"From the very start, at seventh grade, they start learning the expectations of what we want at high school.
"By the time theyw get to high school, they want to go do everything they can to contribute to that effort."
Gatesville and Lampasas now both cohabitate with Burnet, Brownwood, Liberty Hill and Llano in District 8-3A.
"They are some not just good volleyball teams in it, but there are some very good volleyball programs in that district," Phillips said.
And just like Copperas Cove, Lampasas and Gatesville, they all have something to prove.


text:
As we examine Hezbollah stand for up to Israel and Iran cautionary Israel that they will be moving off the map it is noticeable that we could be influential into a much bigger scenario, such as as a WWIII type event. Cease Fire is not likely and now we brainstorm many tough liners talking roughly speaking awheel the planetary of Hamas and Hezbollah in one starring set of attacks.
What are they maxim now? Well they are advising that the United States Military put a Battlegroup in the Area. Paint some aircraft near Israeli markings and truly go to municipality. These hardliners are saying; We can height these places and reference all singular position of Hezbollah and Hamas in Syria, Lebanon in 4 hours. Then tell Iran to stomach lint. First commemorative inscription of ramp up; Take out Iran NOW!
Sounds a bit acerbic and yes this is emphatically a trying line drive get nearer but is it feasible? The tall liners say; We requirement to put off pacifying International Terrorists and the country states, which benefactor them. The quality race does not call for this. We have a ngo for the planned to fuse the World in a Common Cause. We cannot have International Terrorist distractions resistant grouping and the peace.Post ads:
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text: Washington Post's cable television revenue dropped slightly to $188.7 million, from $189.6 million. This decrease was more than offset by strong gains across the company's other segments. For the nine months ended October 3, earnings surged to $198.2 million, or $21.75 a share, compared with earnings of $10.1 million, or $1.08 a share, in the same period a year ago. Revenue rose 10.4% to $3.53 billion from $3.2 billion due to improved revenue at all of the company's divisions for the first nine months of 2010. Education division revenue increased 14% to 2.2 billion from $1.93 billion. Kaplan Higher Education revenue and operating income grew due to an 8% increase in enrollment growth to 112.1 million from 103.8 million, as well as improved student retention. Revenue from its newspaper publishing segment was up 1% to $491.9 million from $485.9 million. Its 3% decrease in print advertising revenue at The Washington Post, due to reductions in retail and classified advertising, was more than offset by the 14% gain in newspaper online revenues. Cable television revenue increased 2% for the first nine months of 2010 to $568.6 million from $559.8 million due to growth in the division's cable modem and telephone revenues. Cable division operating income increased 4% to $126.6 million from $122.1 million due to the division's revenue growth, offset by increased technical and sales costs. -- Written by Theresa McCabe in Boston. >To contact the writer of this article, click here: Theresa McCabe. >To follow the writer on Twitter, go to @TheresaMcCabe. >To submit a news tip, send an email to: email@example.com.


text:
What do we know? Resistance and voters being vocal is working!
Chances are that if you are reading this, you have more than a passing interest in the biggest debate of our lifetimes. There is no more vital issue to human beings than their health, and all of the related activities associated with either being in good health or poor health.
Healthy citizens are the greatest asset any country can have. ~Winston Churchill
With more than 17 years of advocacy under our belts, Florida CHAIN has been a leading voice for access to affordable health care since we began. Our advocacy work continues, as we seek bipartisan solutions to those issues and allow Florida citizens to live their lives without fear of economic catastrophe if someone in their family becomes ill.
Florida CHAIN has been monitoring the ongoing debate and activities surrounding the Affordable Care Act since the election of Donald Trump and the new Congress. The Florida Legislature is busy preparing for session, and there seems to be a "wait and see" attitude in that legislative body on health care issues, although Governor Scott continues to loudly press for an immediate repeal of Obamacare. (see our previous response to the Governor)
Predating the Affordable Care Act, "an 11-country survey found that adults in the United States were far more likely than those in other countries to go without needed care because of costs and to struggle to afford basic necessities such as housing and healthy food. U.S. adults are also more likely to report having poor health and emotional distress. Bright spots for the U.S. include rates of timely access to specialist care, discussion with a physician about ways to lead a healthy life, and coordinated hospital discharge planning.
"In comparison to adults in the other 10 countries, adults in the U.S. are sicker and more economically disadvantaged. The resulting challenge to the U.S. health system is compounded by higher health care costs, greater income disparities, and relatively low levels of spending on social services."
Although the U.S. has made significant progress in expanding insurance coverage under the Affordable Care Act, it remains an outlier among high-income countries in ensuring access to health care. The authors point out that all of the other countries surveyed provide universal insurance coverage, and many provide better cost protection and a more extensive safety net. To address the barriers to access and affordability identified in the survey, policymakers might consider expanding Medicaid eligibility in the 19 states that have not yet done so; limiting the amount people need to spend out of pocket on health care; and creating a stronger primary care system."
One thing everyone agrees on is that there is no easy solution to this issue. The campaign rhetoric from the winning side demanded immediate repeal, heard both from candidates and voters. After the election, many voters came to realize that their own families could be negatively impacted by an across the board immediate repeal. Anecdotal evidence suggests many were confused that "Obamacare" the "Affordable Care Act" were one in the same. Infighting amongst the GOP in Congress might prevent them from getting even a simple majority on their two highest legislative priorities, tax reform and healthcare. The other thing that most everyone agrees on is that lives are hanging in the balance while the politics plays on.
"Some revision of the ACA is inevitable and even desirable. If Democrats and Republicans jointly agree on establishing specific goals for the reform, building on the existing process for monitoring attainment of those targets, it could lead to measurable improvements in the health system. In doing so, the "repeal and replace" campaign slogan could be transformed into 'repair with results.'" – Newsweek
What can we do now to help?
It is most encouraging to see and hear thousands of Floridians raising their voices in support of Affordable Health Care and continuation of the Affordable Health Care Act. Dozens of state and national advocacy sites have formed since the election, joining with more traditional and equally active voices in Florida. We thought we'd share some activities, outlets, resources and opportunities with you, so that you can get more involved, if you haven't already, and add your powerful voice to the symphony. Together, we can make a bigger difference.
- Engage and interact with your elected Congress member and Senator. One versatile guidebook on how to accomplish that is available on the website https://www.indivisibleguide.com/. Former Congressional staffers tell us that the ideal way is to call on the phone directly to your representative's offices.
Our partners at Community Catalyst have offered additional suggestions:
We now know that the 2017 budget reconciliation process, which Republicans plan to use as a vehicle for repeal of key provisions of the Affordable Care Act (ACA), is likely to stretch into late February or early March. In just over a week, members of Congress will head home for President's Day recess (beginning February 18). A longer timeline for reconciliation makes this a critical week of action for health care advocates and supporters across the country to send a clear message to all members of Congress, whether they are vocal opponents or staunch supporters of the ACA, that the current plan to repeal the law with no clear replacement is both reckless and unpopular. In this alert, you will find a variety of materials designed to help you plan your own activities, tap in to others' events, and ensure that you are able to take full advantage of this important week.
Sending the right message
In this effort, it is important that we reach all members of Congress – senators and representatives on both sides of the aisle, from all perspectives in the health care debate.
- ACA Supporters: Now is the time to thank these members of Congress for standing up and to show them they have the support of their constituents behind them. For this group, the key message is: Thank You!
- Targets: members of Congress who are identified as targets for their position on repeal without replace must continue to hear that their constituents want them to stand up against any plan that will harm consumers and their support will be recognized and appreciated.
- ACA Opponents: senators and representatives who are actively and vocally supporting repeal need to know that simply shifting the messaging to "repair" will not work and their constituents expect them to ensure that coverage and protections are not taken away.
Planning activities
When planning for February recess, it's important to keep in mind: 1) your current capacity, including available resources, grassroots reach, and staffing; 2) your current political environment; and 3) the style and intensity of the message you are sending to your members of Congress and to the public. There are several effective options for engagement across the spectrum.
- Recess Activities Graphic:This visual is designed to help you brainstorm what activities may be right for you based on the capacity you have available and how intense your message delivery needs to be (or not be) in order to be effective.
- Recess Activities Toolkit:We walk you through several activities in our newly-updatedrecess toolkit, providing some best practices and logistics to consider.
Dates to remember:
Valentine's Day Call-in Day: Our partners at SEIU have organized a call-in day today, February 14. You can use their toll-free number (866-426-2631), which uses the caller's zip code to direct them to the right congressional target with a sample script for the call.
- February 18 Events with House members: Democratic members of the House of Representatives are planning events across the country onFebruary 18 to defend the ACA, Medicare, and Medicaid. If you would like to attend or spread the word, you can call your Representatives' district offices and ask for details.
- Additional Events Hosted by Members of Congress: Many members of Congress are planning their own events while they are in their home districts for recess. You can be sure that health care is a main topic of discussion by attending these events and encouraging your networks to do the same. This spreadsheet, which is updated regularly, lists town halls and other events being planned by congressional offices. (See the Recess Activities Toolkit for sample questions that can be asked at these events.)


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Whiskey Collins
Mixing instructions:
Shake blended whiskey, juice of lemon, and powdered sugar with ice and strain into a collins glass. Add several ice cubes, fill with carbonated water, and stir. Decorate with slices of orange, lemon, and top with the cherry. Serve with a straw.
Talk about drinks and bartending in The Webtender Forum.
Ask your questions, chat or share your best tricks with other visitors.
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|Message view
|« Date » · « Thread »
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|kristoffer <sto...@gmail.com>
|Self configuring network of brokers
|Thu, 19 Oct 2006 12:24:20 GMT
Hi, Just got my client to connect to brokers using multicast properly, yea! But (comparing with a static tcp connection) performance is so much worse when using discovery:(multicast://default) at the client side. It looks like (correct me if im wrong) every message sent from the client to the broker, causing a multicast discovery in order to find a broker. Why is this behaviour? Is because of loadbalancing? Is there some way that the discovery could be made only when the connection is broken? What i want is to have a loadbalanced system which is easy configurable. I dont want to update all my traffic servers configuration with new tcp urls if I decide to add a new broker. At the same time i dont want any overhead of running multicast, except when a connection failure occurs. Please help me understand if this is feasible or not, if not, what are a common setup? What are my options in terms of performance vs ease-of-configuration? Thank you, -Kristoffer -- View this message in context: http://www.nabble.com/Self-configuring-network-of-brokers-tf2473032.html#a6895670 Sent from the ActiveMQ - User mailing list archive at Nabble.com.
|View raw message


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Question about GE DBSR453EBWW Electric Dryer
Dryer is two years old bought new. making loud griding noise while drying.
Posted by gjackson002 on
does it sound like it's in the back side?
Here is a tip that I wrote about dryers and noises...
It will help you determine what is happening there...
Dryer Repair Squeaks, Grinding, Clicking and Knocking Noise
Posted on Sep 29, 2010
SOURCE: I have freestanding Series 8 dishwasher. Lately during the filling cycle water hammer is occurring. How can this be resolved
a 6ya expert can help you resolve that issue over the phone in a minute or two.
best thing about this new service is that you are never placed on hold and get to talk to real repairmen in the US.
the service is completely free and covers almost anything you can think of (from cars to computers, handyman, and even drones).
click here to download the app (for users in the US for now) and get all the help you need.
Posted on Jan 02, 2017
Tips for a great answer:
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Jan 20, 2008 | Kenmore 63942 Dryer
Jan 10, 2008 | GE DCSR483EA Electric Dryer
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So I've got our ScanJet 7000n up and running. We can scan documents to email and scan them to network folders. The next thing I want to tackle is the Scan to Sharepoint feature. I'm not finding any information about how to do this without having to buy a third party application. Does anyone know any more about this? The setup on the device's web server is pretty simple, but it acts as though there is a permissions problem. I've made sure I'm admin on the page I'm trying to save to but no dice. Any ideas?
This topic was created during version 5.3.
The latest version is 7.5.00101.
12 Replies
Mar 5, 2012 at 5:54 UTC
Are you saving to the Sharepoint folder, or straight to Sharepoint?
Mar 7, 2012 at 7:10 UTC
I was testing it by saving to a document library. Is there another method I should use or another place I should try saving to?
Mar 7, 2012 at 7:22 UTC
If it's the same as previous versions of Sharepoint there will be a folder on your Sharepoint server that you can save to, this will added automatically to the page itself.
If you look at the place on Sharepoint you want to place the item and choose Actions > Browse in Windows Explorer then you'll see the exactly path that you can scan to.
Mar 7, 2012 at 9:37 UTC
I found the folder and I can manually add a document that way, but when I try to scan it in from the scanner it asks me to re-enter my domain, username and password, but that doesn't work. There isn't anywhere on the folder itself where I can add permissions. Not sure what to do about it at this point.
Mar 7, 2012 at 10:28 UTC
Are you authenticating on the scanner already? We've got ours set up to sign in as a "scanner" account which (according to the sharepoint admin next to me) will be allowed to save there as I can directly. If you're not authenticating then that would be why.
Mar 7, 2012 at 11:34 UTC
We are authenticating, but with our individual logins. We are able to email documents and also save them to network folders, but not Sharepoint.
Mar 8, 2012 at 2:27 UTC
That's probably the best way of doing it else you won't know who 'uploaded' the file.
When you saved the file to that location manually, did you do it on the sharepoint server or from your local machine? Hmm, just had a thought - can you set the permissions for that folder through the Sharepoint webpage?
Mar 8, 2012 at 7:03 UTC
No, we're scanning from an HP Scanjet Enterprise 7000n. There isn't a local machine involved other than the scanner itself.
The only permissions I have found you can set are the typical ones in Sharepoint where you grant permissions for a page to a Sharepoint user. I set myself as Owner of the document library page and all the pages above it, but it still doesn't work. It asks for domain, username and password. When I input that information, it fails.
Mar 8, 2012 at 7:07 UTC
Sorry I meant when you manually put the file in the folder (in your second reply)
I'm guessing that you have to enter the same info when scanning to email or a network folder?
Mar 8, 2012 at 7:35 UTC
Ah ok. I did it from my local machine.
If, by info, you mean login information, the user enters that when they first start using the scanner. It does not ask for it again when you scan a document to email or to a network folder, but it does ask for it again when you try to scan to sharepoint.
Mar 8, 2012 at 7:39 UTC
I'm afraid I can't help then, we've been through everything I could think of besides unwieldy options like saving it to a network drive then having a script copy files over every few minutes :-/
Mar 8, 2012 at 7:45 UTC
Bleh. I'd rather not do that but thanks for your help!
This discussion has been inactive for over a year.
You may get a better answer to your question by starting a new discussion.


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Steve Gillespie is two things: adorable and ADORABLE. That's what's most important, but he's also really funny. Gillespie's act is a balance of aggression, slap-happy absurdity, self-flagellation, and blistering social commentary. All enhanced by his coarse yet effective word choice and delightfully pushy persona.
Now a decade into his career, he relocated to LA after freezing half-to-death whilst fist-fighting bearded giants in Minneapolis, made a super-cute national TV appearance on Conan, and released his critically-acclaimed debut album, Stever Fever, which was named one of the top ten comedy albums of the year by Comedy-Reviews.com. He was also featured in the prestigious Boston Comedy Festival, the Bridgetown Comedy Festival in Portland, OR, and appeared on the Fox TV show Laughs.
©2017 KP Comedy • Phone: 866-769-9037


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All Android applications categories
AppMart Company is a company that helps small businesses bring in new customers, increase repeat purchases, and stand out from competition by developing a custom mobile app and mobile website.
If you want to see a Demo preview of a mobile app that we can develop for your business, simply download this app for free and set an appointment through the app.the demo is 100% FREE
-Contact tab - used to contact business
-Coupons tab - GPS coupon, similar to foursquare. Can access coupon when you are in certain distance to business
-Email photo tab - used to email current photos or snap a photo and send it
-Events tab - used to set upcoming events in a calendar
-Home tab - home page with direct calling, directions, and tell a friend
-Image gallery tab - displays images in a gallery
-Mailing list tab - prompts to join newsletter
-Menu tab - used for restaurants, can input prices. Good for single item input.
-Messages tab - push notifications
-Mortgage calculator tab - self explanatory
-QR coupon tab - QR scanner, gives coupon
-Restaurant reservation tab - for making reservations
-RSS feed tab - used for blogs
-Tip calculator tab - self explanatory
-Website tab - used to input any website (not flash iPhone)
Tags: local company , local business , local business mobile
from 1 reviews
Download Mobile App for Local Business
Free - V1.403 - 4M
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Built in 1905 beside a main road and renovated in the year 2000, the city hotel offers a total of 57 double rooms and 25 singles spread over 6 floors. Amongst the hotel's facilities count a foyer with a 24-hour reception desk, a safe and lifts. In addition, the hotel offers a bar, an air-conditioned à la carte restaurant (including highchairs), public Internet access (additional fees apply), wireless Internet access and a conference room. Room and laundry services as well as medical assistance complete the amenities at this hotel.The tastefully furnished rooms include an en suite bathroom and come equipped with a hairdryer, a hire safe, a direct dial telephone, Internet access, a radio and central heating.
From Gatwick Airport take the Gatwick Express to Victoria station. From there take the Circle Line underground train to Bayswater station. Exit the station and turn right, walk for a minute and the hotel is located on the right-hand side. From Heathrow Airport take the Heathrow Express to Paddington station. From there take the District Line or the Circle Line and get off at Bayswater station. Exit the station and turn right, walk to the end of the street (Queenway) when facing the park, turn right onto Bayswater Road and the hotel is located on the right-hand side (3-minute walk).


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The real winners and losers of the Oscars
Published Feb. 29, 2016
Yes, it was the Oscars, and last night provided everything you would want: stars, snubs, surprises and searing Sam Smith-related outrage. But who actually won and lost? Here's my take on the highs and lows of the 2016 Academy Awards.


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My new theory on "The Rules" (if they exist, of course): So imagine a giant chess board. There are two sides (Charles Widmore and Ben). This chess is different from regular chess because the rules and situations are different:
- Instead of having the king killed (or placed in checkmate), the island is on one side and the other side either wants it or needs it.
- Back then, before the plane crash, Ben had the island because he banished Widmore (for unexplained reasons??) and, obviously, Widmore wanted the island back.
- There can be more than two sides (maybe Jacob is one side or maybe the Black Rock or Henry Gale)
- I believe that when the plane crashed, it created another side (more or less a third side), which was the survivors of 815. Since Ben had the island and Widmore didn't, Ben waas trying to kill off the "third side" so that the island would be his again.
Just to be clear, "the rules" are, to this metaphor, the rules to the game of chess. Yes, this still doesn't explain why Alex dying changed the rules, but I would love to hear some ideas. NOTE: This was thought up when I started typing. I don't have a lot of support, but then again, I'm sorta torn between thinking that "the rules" actually exist to thinking that Ben made it all up so he was the victim in the situation. Comments would be helpful.


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Story Of Today – April 1, 2017 – What Made Jessica Lynch A Hero
Today's Story: What Made Jessica Lynch A Hero
In Perspective:Truth Wins
On April 1st, April Fools Day, it is tradition to play jokes on friends – to deceive them in a light-hearted way.
April 1st is the day Jessica Lynch was rescued in 2003. While Lynch's ordeal was real, the government hyped up the rescue for PR purposes. Today, the Trump administration is all about deception. Fortunately some people put truth and loyalty above material gain, people like Jessica Lynch.Continue reading →


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Motorcycle Repair
Call the ScooterDoc for your service needs. 11 years of experience and satisfied customers gives you the unsurpassed customer service you need to ensure your scooter runs to the best of its ability.
We are incomparable to any other service advertisers here. Our technical skills and history ensure you will be satisfied. We also provide for service calls which allows us to pickup and deliver at your most convenient location.
When it comes to getting your Vespa (GTS, LXS, ETS) serviced right; trust that the ScooterDoc can get the job done. Why take the long path to resolution when the ScooterDoc can get it right the first time around. -Basic Service and Break-In oil change -Full Service 48 Point Check -Parts Repairs and Replacements -Service. Pickup and Delivery -Tire Changes -Performance Work -Full Paint and Restoration Services -Accessories and Add-On Work -Full Insurance Service Shop!
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50' Carver 506 Motor Yacht Motor Yacht 2003 Yacht for Sale
Carver 506 Motor Yacht Information:
- 50 Carver 2003 506 Motor Yacht
- Vessel Length: 50 feet
- Vessel Builder: Carver
- Vessel Model: 506 Motor Yacht
- Vessel Year: 2003
- Vessel Name: Sweet Charity VI
- Vessel Type: Motor Yacht
- Vessel Price: $314,900
- Vessel Location: 1000 Islands, New York United States
For more information contact:
Tania Andre
Contact Form:
50 Carver 506 Motor Yacht 2003 Details:
The 50 Carver 506 Motor Yacht 2003 is a stunning display of interior volume unmatched in a boat this size. The enormous full-width salon—focal point of the boat with nearly 7 feet of headroom—is made possible by raising the side decks to eye level, which is why the boat seems to have so much freeboard.
The three-stateroom, galley-down floor plan features a formal dining area across from the galley, three heads and salon seating for a small crowd. Topside, wing doors and aft-deck enclosure panels were standard; a molded stairway leads to the swim platform, and the flybridge hardtop has a retractable sunroof above the helm.
Other interesting yachts for sale


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login with
Frequency of Ultrasounds
I had my first ultrasound at around six weeks. I'll have my second tomorrow, around 14 weeks.
How frequently did you have ultrasounds during pregnancy?
How about 3D? Anyone get a 3D one?
Moms Expertise08/16/14
With my first full-term pregnancy I had 2 ultrasounds: at 24 weeks and at 32 weeks, because my husband believes that ultrasound is harmful for a baby. With my 24-weeks pregnancy(abnormal) I had 3 ultrasounds in a row.
Ooo I love hearing how often gals have them!
Let's see... my first was at 8! Then 12! Then 20! Of course I had heartbeat checks at 10 and 17 too :) I haven't gotten a 3D and don't think I will.. we kind of like the anticipation of not knowing who is in there until they come out :)
Let's see... my first was at 8! Then 12! Then 20! Of course I had heartbeat checks at 10 and 17 too :) I haven't gotten a 3D and don't think I will.. we kind of like the anticipation of not knowing who is in there until they come out :)
With my last three pregnancies, I had one as soon as I found out I was pregnant, a second one at around 18 weeks, and a third at the end to make sure the baby was head down. With this one, I am having them every two to four weeks to check the growth and progress of his heart. I have not had a full 3D one, but I have had the 3D facial profiles with this one, to check for a problem with clef lip or pallet.
Comment deleted
Is it common for them to stop around 20-24 weeks? I thought I was set for more.. maybe not.. maybe I need to re-read my practice packet hahaha
Comment deleted
Ooo gotcha, thanks for detailing and clearing those up, girlfriend!
With my first 2-3 I only had one, maybe two. Then after my losses I'd have them early on and again at 20 weeks. My last three pregnancies I didn't have a single ultrasound (GASP! I know! But I didn't miss them, as long as I heard a heart beat I was good.) and I've never had a 3D one done.
Now I had 3. I am 25 now. And I will have another one at 30 weeks.
Oh awesome... and welcome :) Hope all is going great for you!!!
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About Cassaundra Owens
Birth: February 13
On Moms.com since: Oct 11, 2013
I'm a little strange, pretty green, and learning to live life as a wife, future mother, and entrepreneur. Right now, my husband and I are trying for our first after 3.5 years of infertility and 2 losses. Viva la adventure! Join me too at MortalMommy.com!


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Submitted by djang on
For a current list of cooperating WICHE programs in your field, visit our website. Apply to the participating schools of your choice. When applying for admission, indicate that you have applied for WICHE certification. You are subject to the application deadlines and academic requirements established by each school. Many programs give preferential consideration to WICHE applicants.


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FamilyWize PRESCRIPTION DRUG SAVINGS PROGRAM
IT'S FREE: This is a free resource from the FamilyWize community service partnership. Use this FamilyWize card to start saving money on your prescription drugs today.
IT'S EASY: Simply present your card and prescription to a participating pharmacy to obtain the discounted price. You always receive the lower of the discounted price or pharmacy's retail price.
HOW MUCH YOU SAVE: This card can save you and your family an average of up to 30% or more on 8 out of 10 prescriptions.
NO RESTRICTIONS: Use your card as often as you need, for any prescription, for everyone in your family. There is no income limit, age requirement, eligibility or registration required.
$1 BILLION IN SAVINGS: The goal of this community partnership is to reduce the cost of medicine for children, families and individuals with no prescription drug coverage by $1 billion. FamilyWize cards are being distributed free of charge nationwide by participating United Ways, community and faith-based organizations, county agencies, doctors, businesses, some pharmacies, and individuals like you. The discounts and savings are provided voluntarily by the more than 55,000 participating pharmacies that have agreed to accept this card. Please remember to thank your pharmacy for its participation and those helping to give out the cards for the difference they are making for you, your family and your community.
Click here for the FamilyWize fact sheet
Earned Income Tax Credit
As described on the Internal Revenue Service website, "the earned income credit (EIC) is a tax credit for certain people who work and have earned income less than:
$11,490 ($12,490 if married filing jointly) if there is no qualifying child
$30,338 ($31,338 if married filing jointly) if there is one qualifying child
$34,458 ($35,458 if married filing jointly) if there is more than one qualifying child."
You cannot be married filing separately. A tax credit usually means more money in your pocket. It reduces the amount of taxes you owe. The EIC may also give you a refund.
We encourage eligible families to take advantage of this tax credit opportunity. The credit is an opportunity to increase your family's budget to cover your basic needs, your children's school needs, or other important items to benefit your family.
For more information about the EIC, visit the IRS Earned Income Tax Credit page or call 1-800-TAX-1040.


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Nasha Lavka
A small but very dedicated team of culinary enthusiasts. The abundance of delicious photos and video recipes. Secrets cooking and tips on choosing the right foods. And over time - delivery of natural and farm products to your table. For those who remember the taste of my childhood.
For those who are tired of synthetic packages and the same content
Thank You!


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Hi is there a way to remove sections in the new beta version?
I am in the process of installing it for test purposes. I want to be able to remove the Purchasing tool bar, as we dont need to use it for our company.
I think it would be a great feature if we couls select the built in tools that we needed to use. For example we only need to use the helpdesk and the dashboard tab.
Anyone know if this is possible?
3 Replies
· · ·
Apr 30, 2012 at 5:15 UTC
I dont think it is possible, but the idea is great.
· · ·
Apr 30, 2012 at 7:19 UTC
I agree that would be a nice feature.
· · ·
Apr 30, 2012 at 7:43 UTC
New FR


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When you are pregnant, the thoughts and feelings you experience can range from happiness and contentment - "I can't wait to hold my new baby", "I'm going to be a great mother" - to worry and stress - "Will I ever lose all this weight?", "Can I really support a baby on this pay cheque?" It's normal to experience these types of feelings. Your moods are changing right along with your hormones and your body. That's why your emotional health is more important than ever!
Learn the signs and symptoms of depression (see the next page) and contact your doctor if you feel you may be depressed.
Your body is busy 24 hours a day as your baby develops and it's hard work. If you're tired, don't skip sleep. Put your feet up, take a nap or just slow down. You'll feel better physically and mentally.
Make sure you are eating enough to nourish your baby. Eat regularly - don't skip meals - and make sure you drink plenty of water. You also need physical activity. A walk outside or swimming at the pool can leave you feeling refreshed.
If certain people or situations cause you stress, avoid them as much as possible. And don't take on added responsibilities at work or in your community. Having too much to do can be stressful at the best of times. Learn to say "no!"
Take care of yourself by eating well, staying active and finding time to relax and rest when you need it.
Accept offers of help from friends and family.
Share your thoughts and feelings with others. If you are worried, upset, sad or anxious, talking about it can help. Confide in your partner, a trusted friend or a family member.
Mood swings are a normal part of pregnancy. Pregnancy triggers an outpouring of various hormones. These hormones can change the level of brain chemicals (called neurotransmitters) that, in turn, regulate mood. Some women may be moody all through pregnancy, but it's most common around the sixth to tenth week and then again in the third trimester when your body is getting ready for labour and delivery.
Unless your doctor specifically advises you otherwise, sex during pregnancy is safe for both you and your baby. Intercourse can't hurt your baby or cause a miscarriage. You may find you want to have sex more than you did before you became pregnant. On the other hand, wanting sex less is perfectly normal too. Most couples resume an active sex life sometime during the first year of their baby's life.
It's possible. Check with your health care provider if you have four or more of these symptoms for at least two weeks or if any of these symptoms particularly concern you:
For More Information
Information on emotional health
You can also go to the Mood Disorders Society of Canada Web site and the Canadian Mental Health Association's