text:
|Specific References
|Related Products
|Recombinant Human HAVCR1 protein (Catalog#11051-H07H)
|Rabbit IgG
|0.2 μm filtered solution in PBS with 5% trehalose
|Produced in rabbits immunized with purified, recombinant Human HAVCR1 / TIM1 / KIM1 (rh HAVCR1 / TIM1 / KIM1; Catalog#11051-H07H; AAC39862.1; Ser 21-Gly 290). HAVCR1 / TIM1 / KIM1 specific IgG was purified by Human HAVCR1 / TIM1 / KIM1 affinity chromatography.
|Human HAVCR1 / TIM1 / KIM1
WB: 20-40 μg/mL
ELISA: 0.1-0.2 μg/mL
This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human KIM1. The detection limit for Human KIM1 is approximately 0.00245 ng/well.
IP: 1-4 μg/mg of lysate
|This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Human HAV cellular receptor 1 (HAVCR1), also known as Kidney injury molecule 1 (KIM-1) and T cell immunoglobulinmucin 1 (TIM-1), is a type â… integral membrane glycoprotein. KIM-1 protein is widely expressed with highest levels in kidney and testis. It has been shown to play a major role as a human susceptibility gene for asthma, allergy and autoimmunity. IgA1lambda is a specific ligand of KIM-1 protein and that their association has a synergistic effect in virus-receptor interactions. KIM-1 involves in the pathogenesis of acute kidney injury. It had been confirmed that KIM-1 is a human urinary renal dysfunction biomarker. Moreover, KIM-1 protein is a novel regulatory molecule of flow-induced calcium signaling.
|Product name
|Product name


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Dermabrasion Q&A
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Two of Kentucky's starting guards, De'Aaron Fox and Malik Monk, picked up a pair of fouls before the first media timeout as the Cats saw a 9-0 lead out of the gates quickly disappear.
Calipari's solution? Veto his two-foul rule, put the young freshman standouts back in the game, and cross his fingers.
It worked. Fox and Monk avoided foul issues the rest of the night and came up with some huge scores down the stretch as the No. 6 Cats held on for an 87-81 victory over the Commodores.
"If I've coached a thousand games, I've only done that a handful of times," the UK boss said.
The backcourt trio accounted for all of the Cats' final 27 points. Fox had 12, Monk had nine, and Briscoe had six.
Briscoe led Kentucky (14-2, 4-0 SEC) with a career-high 23 points, seven rebounds and five assists. Fox followed with 22 points, while Monk added 18. Freshman center Bam Adebayo gave the Cats a fourth double-figure scorer with 14 points and pulled down seven rebounds.
"Good win for us," said Calipari, praising the hostile environment and effort that Vanderbilt displayed. "... They shot a ton of free throws and made some 3s. We need this type of game to show us where we need to go."
Vanderbilt (8-8, 2-2 SEC) had a trio of players post 19 points: Matthew Fisher-Davis, Riley LaChance and Jeff Roberson. Luke Kornet added 16 for the Dores, who shot only 43 percent but scored 23 points at the free-throw line and made eight treys.
In this AllWildcats "Rapid Recap" feature, we touch on some quick-hitters from the game...
Kentucky overcame a lot of adversity in perhaps the toughest venue it will play in from this point until the end of the season. The Cats survived massive foul trouble and a lack of perimeter firepower on a night when they hit only one of nine from beyond the 3-point arc. Briscoe's veteran presence was huge in that regard, and Adebayo showed he could carry the team at times in the first half when Fox and Monk were on the bench. The defense still isn't there yet -- nowhere near Calipari's traditional standards -- but the Cats still found a way to come up with some stops at the right time and pull out a hard-fought win.
Isaiah Briscoe, Kentucky -- Almost every time the Cats needed a clutch bucket to hold off a potential Vanderbilt run, it was Briscoe doing what he does best: attacking off the dribble and finishing strong at the rim. Due to foul trouble among all of UK's other guards -- including reserve Dominique Hawkins -- Briscoe nearly went the distance for the Cats, playing 39 minutes. "Proud of him, toughing it out," Calipari said. The sophomore from New Jersey is now averaging 17.5 points, 6.5 rebounds and 6.0 assists in SEC play.
6 - Turnovers for the Cats, a season-low.
9 - UK's biggest lead of the game, scoring the first nine of the night.
40-34 - UK rebounding advantage. Vandy had only four second-chance points.
51 - Percent shooting from the field for the Cats, the 11th time they've been over 50 this season.
142-47 - Kentucky's all-time series lead against Vanderbilt.
"Last night in that (national championship) football game, what happened if someone broke down? Touchdown! That's sort of like us right now." -- UK head coach John Calipari relating his young team's defensive breakdowns to the high-scoring Clemson-Alabama game.
Kentucky returns to action on Saturday against Auburn in a 4 p.m. ET tip at Rupp Arena. The game will be broadcast on ESPN. Bruce Pearl's Tigers (11-5, 1-3 SEC) won 77-72 on Tuesday night at Missouri.


text:
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Back to the future
By Patty Kruszewski, Citizen Managing Editor 10/17/02
Ask a social scientist about the roots of sprawl, and he's likely to point to the 1950s economic boom, the rise of interstate highways and our American love affair with the automobile.
Ask William Abeloff, and he'll point to 1606 and the London founding of the Virginia Company.
In a narration rich with historical detail and quotes from 17th century documents, the recent speaker at a meeting of the Western Henrico Rotary Club drew frequent parallels between modern suburban developers and London investors of centuries ago – from their identical urges to develop "far-off, underutilized real estate" to their intense focus on the bottom line.
"[The Virginia Company venture] wasn't a venture into the unknown, or based on some romanticized ideal to develop the New World," Abeloff told the group. "It was based on economics and the opportunity to create new sources of revenues."
Reaching the falls of the James River a mere four days after the Jamestown landing, Captain Christopher Newport encountered a site that appeared made to order for his backers at the Virginia Company, who had instructed him to "find out a safe port in the entrance of some navigable river...and such a place you may perchance find a hundred miles from the river's mouth, and the further up the better."
The settlements that were soon to line the James in Richmond and Henrico, said Abeloff, can be viewed as examples of "the ultimate sprawl from downtown London."
And just as Henrico played a key role in the growth of that four-centuries-old venture into a new nation, it appears that the county will soon join another trailblazing effort – one that could set a precedent for the rest of the nation in reversing the sprawl so devastating to modern cities.
Abeloff, who converted tobacco warehouses into loft apartments to form the largest historical rehabilitation project in the United States (Richmond's Tobacco Row), has his eye now on a mile-long piece of riverfront straddling the city/county line at Rocketts Landing.
The run-down industrial district near the convergence of the Osborne Turnpike and Williamsburg Road, named for a ferry operated by Robert Rockett in 1730, was once the busiest port in the Western Hemisphere. But decades of neglect have left the once-bustling neighborhood languishing, said Abeloff, "like a piece of tarnished jewelry, practically right under our eyes.
"That industrial development has had the effect of cutting us off from that part of the river – with its large buildings and chain link fences blocking access," he added. "That's why if you haven't cruised on the Annabel Lee riverboat or driven down Route 5, chances are you have never seen Rocketts and don't even know where it is."
What's more, said Abeloff, "It's about one mile of choice riverfront property within walking distance of Tobacco Row, Church Hill, Shockoe Bottom, Shockoe Slip and even downtown that today pays the grand total of $50,000 a year in property taxes to Richmond and Henrico."
Abeloff's plan calls for private investment of $250 million to develop almost 50 acres into commercial offices and residential units, a green waterfront park and promenade, retail space, restaurants, hotel and boat dock – "all with absolutely spectacular views of the James River and downtown Richmond's skyline."
Investors in the project include such prominent Richmonders as James E. Ukrop, E. Claiborne Robins, Jr., and Circuit City chairman Richard L. Sharp; among Henrico supporters of the plan, Abeloff numbers county manager Virgil Hazelett (a member of the Rotary group who voiced his enthusiasm for the project at the meeting) and members of the Board of Supervisors. In August, the Board voted unanimously to adopt a new mixed-use zoning classification that will pave the way for the Henrico portion of the project, which is slated for the first phase of development.
Another of Abeloff's prominent allies is Virginia Secretary of Natural Resources Tayloe Murphy, a long-time conservationist who has hailed the project as a "crucial component of the emerging economic vitality of the City of Richmond...[and] a unique opportunity to address environmental, historic preservation and land development issues all at once."
As Abeloff noted, environmentalists find it easy to embrace the Rocketts project because it promises to enhance the environment as it boosts the tax base – unlike typical developments, which reap #their economic rewards at the expense of negative environmental effects. Foremost among the economic benefits of Rocketts Landing, said Abeloff, will be an estimated annual tax yield of $6 million for city and county treasuries.
By the end of October, Virginia's Department of Environmental Quality is expected to approve a plan of remediation for the project that Abeloff expects will become a model for brownfield development across the country.
"By re-using land so close to our downtown," he emphasized, "[Rocketts Landing] represents an anti-sprawl project reflecting the best aspects of smart growth. It represents brownfield redevelopment at its best – the antidote to sprawl."
On May 24, 2007 – 10 days after the celebration of Jamestown's quadricentennial – Richmond will mark the 400th anniversary of Christopher Newport's sail into the harbor. Abeloff hopes by then to have a riverfront village that will not only draw the locals to "live, work, shop and play," but will pull Jamestown tourists up Route 5 and I-64 to see what Richmond has to offer.
A self-described "recovering lawyer," Abeloff told the Rotary gathering at the Westwood Club that he grew up nearby in a red brick house at Club Lane and Libbie Avenue.
Perhaps the old golf course he had for a playground, or the horseback rides he took to Short Pump and back, Abeloff said, contributed to his interest in the environment and preservation. At any rate, he reflected, he and his fellow investors believe they have more at stake in the project than a simple return on investment.
"As I hope you can tell," Abeloff concluded, "we at Rocketts Landing are out to create something for Richmond that goes beyond a simple real estate development. We're trying to reclaim and re-use some of the most important, vibrant, historic property around.
"Most of us," he said, "see this as an opportunity to do something great for the place we love – our hometown."
New utility services number for metro area
Citizen Staff Reports 07/27/2017 General NewsGovernment
Richmond city, Henrico, Chesterfield and Hanover county natural gas customers have a new number to call for their utility services.
The City of Richmond Department of Public Utilities has replaced its old number, (804) 646-7000 as well as 311, with it's new number, (804) 646-4646 for all calls relating to utilities. Utilities include natural gas, water, sewer, storm-water and electric street-lighting. > Read more.
The City of Richmond Department of Public Utilities has replaced its old number, (804) 646-7000 as well as 311, with it's new number, (804) 646-4646 for all calls relating to utilities. Utilities include natural gas, water, sewer, storm-water and electric street-lighting. > Read more.
Henrico County property transactions, July 10-16
Citizen Staff Reports 07/26/2017 General NewsProperty transactions
A sample of property transactions during this period appear below:
3714 Pemberton Ave.- $105,000, 720 SF (built in 1957), from William F. Patton Jr. to Jessica Garcia.
510 Besler Ln.- $121,000, 964 SF (built in 1986), from Joseph and Coral P. Bolden to Taneen Marlow.
3502 Westcliffe Ave.- $140,000, 1,564 SF (built in 1947), from Benny H. Wilson Jr. to Benjamin A. Nyannor. > Read more.
FirstComp Insurance Company, Markel Corp. named top insurance carriers
Citizen Staff Reports 07/26/2017 BusinessGeneral News
Two Glen Allen-based insurance carriers have been named among the top such companies in the nation.
Markel Corp. and FirstComp Insurance Company (now owned by Markel) are among 38 carriers recognized on the Insurance Business America list of the top insurance carriers in the country. > Read more.
Walmart honors Citizen's 'Top Teachers' during grand opening
Citizen Staff Reports 07/25/2017 BusinessEducationGeneral News
The much-anticipated new Walmart Supercenter in Eastern Henrico opened to busy crowds last week, and company officials welcomed a special group of shoppers, too. > Read more.
'It's such a blessing'
By Ashlee Korlach, Special to the Citizen 07/24/2017 FeaturesGeneral News
On Independence Day, a Brazilian-born Henrico resident took the Naturalization Oath of Allegiance on the steps of the Virginia Historical Society and felt peace finally settle around her.
Jeanette Hamlett's journey to U.S. citizenship is a story of faith and love, which she told with her husband, John Hamlett, by her side. > Read more.
'It's such a blessing'
Preschoolers give pillows to families in need
Dairy Queen's Blizzard sales July 27 to benefit Children's Hospital of Richmond
Crime Stoppers' Crime of the Week: July 24, 2017
Henrico Police locate missing man
- More News
Print Edition
Jul. 20, 2017Current edition | Archive
Restaurant Watch
Weekend Top 10
'Five Flights' opens July 20 at CAT Theatre
Henrico actress lands role in Christian TV series
All's fair in food and fun
- More Entertainment
Obituary – Hoyle S. "Chick" Walters
Obituary – Janet Sue Vest
Obituary – Barbara Jean (Chilton) Crider
- More Obituaries
Glen Allen woman raising companion dog
Guided tour of Malvern Hill planned as part of 'History at Sunset' series
Anthem LemonAid registration now open
- More Community
Growing a grown-up: Part II
How to grow an adult
Make 'em take the pledge: no more snuff boxes!
- More Opinions
Code Lacrosse joins Richmond Strikers
5 Henrico student-athletes win scholarships at awards dinner
RIR to host playoff race in 2018
- More Sports
|July 2017
Place an Ad | More Classifieds
CalendarSenior citizens group Elderberries will meet at 11:30 a.m. at the American Legion Post #244, located at 2522 Indale Rd. in Glen Allen. Everyone is welcome. The group meets the second Wednesday of each month, year-round. For details, call Brenda Anderson at 672-0074. Full text


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CCP Fozzie "We can see how much money people are making in nullsec and it is, a gigantic amount, a shit-ton… in null sec anomalies. "*
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Miley Cyrus Bikini Photos: Barcelona
"Bebida púrpura, por favor!"
With that complexion, she could get a moon burn.
When it's all-labia-all-the-time, you can forget how stupid that armpit dream catcher is.
Exactly what dream does one want to catch in the armpit…?
Helping Hand: Well then, come on, which way?
Miley: Which way?
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Miley: I guess I'll go down.
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She is one Nasty whore.


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South Africa reached tea on 25 for one after they dismissed India, who won the toss and chose to bat, for 414.
Medium pacer Pollock took four for 75, while debutant left-arm spinner Harris claimed four for 129.
India resumed on 254 for three, and they lost their fourth wicket in the eighth over of the day when fast bowler Dale Steyn uprooted VVS Laxman's off-stump to bowl him for 13.
Sachin Tendulkar and Sourav Ganguly shared 68 for the fifth wicket before Harris had Tendulkar caught by Jacques Kallis at slip for 64 with a delivery that turned sharply out of the rough.
Tendulkar's composed innings included 11 fours and came off 130 balls.
Virender Sehwag, who was demoted to number seven after struggling at the top of the order in the first two tests, was out for an increasingly aggressive 40 when he pulled at a delivery from Harris and was caught by Makhaya Ntini at deep backward square leg.
That reduced India to 395 for six, and in all the visitors lost their last five wickets for 19 runs.
Ganguly, who was struck a fearsome blow on the helmet by Steyn with the third ball he faced, was last out for 66 when he skied a delivery from Pollock to Hashim Amla at mid-off.
Graeme Smith began South Africa's reply in spectacular style when he hooked the first ball of the innings, bowled by left-arm fast bowler Zaheer Khan, over the fine leg boundary for six.
Fast bowler Shanta Sreesanth struck back for India in the fourth over before tea when he had AB de Villiers caught behind off the inside edge by wicketkeeper Dinesh Karthik for one.
Smith was 21 not out at tea with Amla on three.


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House Committee to Hold Hearings on EphedraMar 5, 2003 | New York Daily News
Congress cranked the heat up on ephedra companies on Wednesday as a House committee made plans for hearings on the herbal supplement linked to the death of Orioles pitcher Steve Bechler.
The House Commerce and Energy Committee will hold hearings, perhaps this month, to determine whether the Food and Drug Administration has authority to regulate ephedra.
The committee has also asked Cytodyne Technologies - the New Jersey company that makes Xenadrine RFA-1, the diet aid Bechler used for information on consumer health complaints and lawsuits.
"I hope that this investigation is the first of many steps that will lead us to comprehensive regulation of the dietary supplement industry," said Rep. Susan Davis (D-Calif.), who has pushed for hearings on ephedra for more than two years.
Suffolk County executive Robert Gaffney, meanwhile, signed a bill on Wednesday making it illegal to sell ephedra in the eastern Long Island county, the first outright ban in the nation.
"This is the first step, but I'm hoping this goes far beyond Suffolk County," said legislator Jon Cooper, the bill's sponsor.
"Ephedra kills. Ephedra should be banned in Seattle. It should be banned in Sacramento. It should be banned, period."
Suffolk lawmakers approved the ephedra ban before Bechler died, but calls for stricter regulation after his death added national pressure on Gaffney to approve the bill. It will become law in 30 days.
"Bechler's death made it all but a certainty the bill would be signed," Cooper said.
He said it is crucial that Congress amend the Dietary Supplement Health and Education Act, the 1994 law that allows companies to sell supplements without testing for safety.
"Some of these companies are already replacing ephedra with other stimulants and marketing them as if they are safer," Cooper said. "That's what happens when you place profits above health."
Bob Wagner, president of supplement distributor Wagner & Co. in Bohemia, L.I., blasted the ban.
"I'm embarrassed to be a resident of Suffolk County," he said. "This is un-American. You can buy cigarettes, you can buy alcohol, but you can't buy an herbal product to lose weight."
Ephedra, linked to strokes, heart attacks and more than 100 deaths, has been banned by the NFL, NCAA and International Olympic Committee. Last month, Major League Baseball banned its use by players with minor league contracts.
Sports officials, public health advocates and a handful of politicians have called for Congress to amend DSHEA for years, but their calls went unanswered until Bechler's death. "His death has changed the political landscape," Cooper said.
Sen. Richard Durbin (D-Ill.) now believes he can muster enough support to amend DSHEA, and he's working on a bill that would subject ephedra to much stronger FDA regulation. Federal regulators have proposed new labels on ephedra products to warn consumers of the risk of heart attacks, strokes and death.
"People have asked me if it bothers me that nothing happened until a professional athlete died," said Karen Schlendorf of Northport, L.I., N.Y., whose son, Peter, died seven years ago this week after using an ephedra product. "It doesn't. I'm glad our county is saying health and safety come before profits.
"This (the Suffolk ban) is just the first step. Now we have to get a national law passed."


text:
The Federal Communications Commission started work on a plan to deploy broadband to all citizens. While the FCC is soliciting feedback to determine what polices should be included in the roadmap, the overall goals of making it avaible to the entire nation, enhancing the quality of service and lowering the overall cost are the tentpoles of this iniaitive. Funding for this plan would be provided paritially by the $7.2 billion dollars earmarked in the stimulus bill passed by congress.
At Fastcase, we can barely recall the days when we were forced to use dial up internet access. What do you think of this FCC iniaitive? Leave your feedback in the comments!
Source: The Washington Post


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Tell your employees the following when doing a toolbox talk on driver safety
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Hello folks!
Oh dear, I cannot believe it has been two MONTHS! Really, I am so sorry I let everyone wait so long! Life has just been crazy and time flying by at the speed of sound (or at least to me it feels like it did). Scarcely did I have time to sit down and write, which is why this chapter comes so horribly late to you. :(
Stitch: I hope you found the message I left for you on my profile. Thank you so much for prodding me. I was already half way through ch13 when I received your note, but still it definitely was a motivation-booster. ;) Also thanx a bunch for the lovely review on ch12. I'm super happy to know you're still following the Rise and hope you'll like the next instalments, too. *fingers crossed*
(Btw.: You moved half way across the world? Wow! All the best then for what I guess could be called a new life!? :D)
About this chapter: As you surely noticed already I broke "Darkness falls" down into two parts. I did so because while writing I noticed it became quite long and I wasn't even finished with it yet. So that's why here's the first half of it. It's more of an in-betweener I am afraid – it's main purpose being to prepare the main part. Still I hope it's worth the read.
As always my heartfelt thanks goes to my amazing readers: AFairy88, AnimePrincess, Stitch and Yen. And a super warm welcome goes to MJ and Teti – glad to have you onboard, you two! 3
Special thanx goes toTeti for giving this a first read, and to MidnightDew and Whisper without whom this story would have never found its way online.
Love you all!
And now, enough of my endless chatter! Go off reading. I really hope you'll enjoy the chapter.
Hope to see you again in part 2.
Chapter 13: Darkness falls part1
The crimson moon was moving slowly on the dark night-sky, its path already decided on eons ago. Turok's eyes lay intently on the satellite, his mind focusing on the faint magic that still filled the air. It had grown noticeably weaker since their first attack, but much to his displeasure it had not yet ceased to exist. The phoenix was still alive, trying to heal the wounds that he and his daughter had caused. But Turok was more than willing to not let that happen. Unconsciously he folded the fingers he had brought up to hover in front of his chest and interlaced them so that he could linger at the cave's entrance in his favourite pose. From behind him he heard the soft rustling of palm leaves fanning the stale air, their movements caused by his daughter's spell.
Rumina lay on the divan, her eyes slightly closed as she obviously was intent to relax. The colour had returned to her face and her breaths were even, the silken dress shuffling quietly as her chest rose and fell.
The young sorceress had recovered quickly from their earlier try and feeling her father's confidence fuel her own one, too, she stretched slightly before she tilted her head a little and let her gaze settle on the silhouette of the older man.
"We should make sure that this time he cannot escape", she spoke seemingly casually but there was something in her voice that told she was not taking it lightly. The amount of power the sorceress had felt radiate from the blood red stone was greater than anything she had ever encountered before and knowing she once more would try to get a hold of it and turn it against its holy source unsettled her as much as it excited her.
Her father, who barely acknowledged her words with a small nod, remained silent for a moment before suddenly he turned around and let his dark eyes find her.
"We know now what we have to expect. Sinbad might have found out what he is supposed to do, but it was sheer luck that guided him. This time we will be prepared."
Rumina watched him wordlessly before she shifted and waved with her right hand, letting the palm leaves sink to the ground with this simple gesture.
"I reckon it is time soon, father?", she then stated while her gaze strayed to focus on the crystal which lay idly still in the centre of the cavern. The once colourless object now displayed the same dark colour which it had gained through their earlier spell, yet there was something faint about its shade, something that spoke of weakness and of a power not unleashed.
Restraining a frown, the brunette finally sat up and left the divan, taking deliberate steps towards the stone. As she moved, she felt Turok nod at her silently before he, too, set himself into motion.
"It won't be long till the moon hits the second mark, and when it does we will reach out to its might once more."
The old sorcerer's voice sounded a little distant as he spoke, his mind obviously occupied with more thoughts than just this one. For a second, Turok seemed to mull over something when suddenly his gaze darted towards a certain point at the cavern's wall and next he stretched his right arm, sending a bolt of black magic to meet with the stone. Through the newly formed hole the strangely warm light entered the cave anew and as the moon's silhouette slowly crept to fill the emptiness he had created, his daughter saw with satisfaction how the crystal came to life again. Kneeling down right in front of it, she let her hand hover above the glimmering surface, her golden bangles clinking softly as she did so.
She could feel the power return to the stone, just like she could feel its source fill the air. Once more would she use it to unite her magic with her father's and once more would they attack the only beast that was left to protect this world. But this time, she was sure, she would not fail. And as Turok settled down next to her, she looked up into her father's eyes only to find them mirroring her own confident smile.
Sinbad drew a deep breath as slowly he made his way towards the sacred chamber where he knew his friends were already waiting for him. His steps echoed faintly in the vast hall that he passed, his gaze wandering around aimlessly as he tried to avoid the curious looks of the younger priests who lined the galleries in silence.
Each of them was attired in a crimson cloak - much like the one Malik had worn earlier this day. The prayers had not yet begun as they waited for the other priest to join and lead them in their task. Sinbad stifled a groan as he felt them watch him, grateful that the darkness hid most of their faces under its veil.
He had spent the last hour by himself, had thought about the words the high-priestess had bestowed upon him and about the truth which he so successfully had failed to see. He still had difficulties coming to terms with everything, but there was a certain peace he had found which lay in what Chiara had said and the same one kept him going now.
It was when he came to walk past the little rose garden which marked the centre of the hall that a rueful smile tugged at the edges of the sailor's lips. It had taken him long, too long almost, to understand. But finally he had come to see that what they had been so sure was a sign of Bryn's destiny had in fact all along been the revelation of his own.
The roses had not blossomed when the sorceress had noticed them at the market, that much he knew now, but when he had arrived at the fountain, too. He had seen it with his own eyes, yet he had refused to recognize the truth. He had surrendered to the simplicity of the solution his friends had offered; had believed in what would have been so easy for him.
He couldn't do so anymore.
Too much was at stake this night; too much he couldn't bear to risk losing. He wasn't sure whether it would truly be enough, but for once in his life the captain would do as he was told.
Sinbad, Master of the Seven Seas, was finally willing to let his heart take the lead.
It was late in the night when Maeve awoke from a dream, the remnants of the images she had just seen fading quickly as her eyes opened to the pale but strangely colourful light of a full moon.
For a second the young sorceress tried to figure out just what it was that had disturbed her in her slumber, but her mind was too foggy still to remember either the dream she had or anything else that might have been unsettling. Her chamber was quiet, the only sound coming from the mild breeze which ruffled the curtains framing the window she used to leave open – a habit that she had not abandoned although she knew that there would be no bird of prey swooping through it here.
Turning to her side, she took another moment to notice that everything in her room seemed untouched and peaceful with no change to what it had been like in the evening. Nothing appeared different, nothing but that dim red glow which her every surrounding seemed to be bathed in.
Her consciousness suddenly fighting sleep away quickly, the Celt sat up in her bed, her gaze settling on the crimson shape that hovered high above the horizon and which seemed to belong to a world so far away from the one she lived in. Taking it in, she felt a frown form on her face. She couldn't name what it was that stirred inside of her as she became aware of how the sky seemed to be illuminated by the star, but for some reason she knew that something about what she saw was meaningful, and most special.
Had she been in any other place, at any other time, she might have now become wary; might have even thought of seeking DimDim. But here, in this realm where nothing existed but the island and its two inhabitants, there was no need to be cautious. In those two years she had spent here no other soul had found the way to its shores, no other magic had penetrated the spell which kept them prisoners and thus, when she saw the crimson glimmer dance on her skin, she felt nothing but wonder and a certain kind of curiosity that for long had been missing from her heart.
Grasping for the brown leather vest which she still used to wear above her white linen blouse, Maeve gingerly got up, her eyes never leaving the bright red moon outside. While she got dressed her thoughts wandered to contemplate this that she saw and she wondered if it was something that was normal in this place, something that she just had missed on before, or whether it was a rare occasion that heralded anything to happen. Whatever it was though, the Celt came to the conclusion that nothing bad lay in what she felt and thus quietly she exited her room and headed towards the backdoor.
Leaving the little adobe behind, she passed the garden where the moonlight almost seemed to sparkle on the velvet petals of DimDim's white roses. And as she lingered for a moment, mesmerized by the creatures' beauty, she didn't notice how, from behind, the loving gaze of her master lay on her, watching her every step and sending a silent prayer to guide her well...
Malik inclined his head as Sinbad finally reached the sacred chamber.
"The high-priestess is already awaiting you", the young man spoke calmly, "as are your friends."
Then he stepped aside a little, pointing with his stick towards the door.
"I will resume my guard at the temple gates. You may enter whenever you feel the time is right."
Not seeing the necessity to voice a reply to the priest's words, Sinbad just bowed his head in gratitude, relieved for some reason that the other man granted him another moment or two to brace himself for what was to come.
Sinbad remembered quite well how Bryn had stood in the centre of the chamber earlier, her friend's gazes – his own gaze – lying on her intently as they expected her to work miracles.
While Malik set himself into motion, Sinbad exhaled sharply. He heard the quite shuffling of boots that passed the lithic temple floor and while there was not a single whisper to travel the distance he was well aware that some of the priests turned to steal one last glimpse of him. Feeling his shoulders stiffen at the thought, the sailor finally decided that he would much rather have his friends' eyes lie on him and thus he stepped forward and reached out with his hands to open the massive door. But right before their tips could even touch the wooden surface it creaked open, leaving Sinbad to flinch slightly.
For a heartbeat he stared at the entrance bewilderedly, his hands still floating in the air in front of him, before he came to notice the girl who stood opposite to the door, a knowing smile covering her delicate lips.
"I am pleased to see you, captain. Come, enter."
And with this she described half a circle with her right lower arm, inviting him in with this gesture.
Sinbad's head shook unnoticeably as once more it puzzled him just how the young one seemed to know things one would think to be hidden from her but then he remembered what she had told him earlier that night. And as he saw her at the far end of the room, next to the reliefs, the warm light of flickering flames once more enveloping her frame, he believed that what she had said had to be true.
"I hope I am not too late."
Sinbad spoke these words with a serious voice; however, he did not only aim to direct them at the high-priestess but also the priest who had positioned himself next to the girl. Lofar's eyes narrowed just a little as he understood the recourse to his earlier scolding when the sailor had been the last to join his friends before the first call. And just for a second the older man seemed tempted to say something. But as soon as Chiara's voice travelled through the chamber again, he straightened up, just for once ignoring the seafarer's words.
"What makes you think you could be too late? I promised you would be told when the time has come and so you were."
The young one seemed somewhat puzzled by Sinbad's statement and yet there was an unmistakable trace of humour in her tone that the sailor couldn't help but interpret as her having quite a fair idea of what he might have been referring to. But she seemed to know better than to comment on it any further and before the sailor even had the chance to ponder over how much she might really be aware of, the priestess turned to Lofar and nodded before she moved to cross the distance that separated her from the central pillar.
In the same instant in which the older priest received the sign, he signalled for the chamber's doors to be closed. Just like it had happened earlier that night, two of the priests who guarded it left the room in order to position themselves at the other side, making sure no one would enter during the ceremony. While the other two remained inside with their halberds firmly held in their hands, Chiara had already arrived at the centre where the holy stone rested securely in the warm light provided by the fires.
Her empty gaze lay on the stone and if one just watched her well, for a second it seemed that its crimson colour reflected in the hazy white that was the girl's eyes. Her own back straightened, the young one seemed to see something in the crystal that was only there for her to see and not for the first time it had Sinbad wonder just what the creature had truly given her when it had chosen her to be its priestess.
"Please, captain. The moon has almost reached the mark."
Her gentle voice had his thoughts dissolve momentarily and when despite how calm she sounded he became aware of the slight urge that lay in her words he nodded at her, letting the quite thuds of his boots follow as he made his way towards her.
Only out of the corners of his eyes did he thereby see his friends and family. Sinbad knew they were likely to have questions. He had avoided them ever since it had been revealed that he was the keeper, had needed the time for himself. And although he was sure that not one of them took this amiss he also was certain of that they worried about him. His friends had seen him change after Maeve had been washed overboard, and they had seen him be so close to giving in to the grief he could not voice out. They had seen her fire in his eyes and yet none of them could comprehend what it meant to him what Maeve had done. What it would set into motion.
Even he, himself, didn't know the latter.
"We're always with you, little brother."
Sinbad's head snapped upwards when he suddenly felt Doubar squeeze his shoulder lightly, a whisper accompanying the reassuring gesture. The older man's pale blue eyes sought his own before he briefly averted them downwards to where the bracelet gilded the captain's wrist.
"As will the Lass I know."
For a second Sinbad felt his brows rise in confusion, both from how obviously he had ended up pausing in his stride and from the words the other one had chosen. It seemed to him his brother knew to read what went on deep down inside of him, and that he was aware what secretly he wished for.
Fighting back a sigh, the captain moved his head in the smallest of nods, trying to express gratitude for what had been spoken. He knew that all the one man who was left of his original family wanted to do was help, and he felt his lips curve ever so slightly as he felt a certain kind of warmth flood his senses upon this thought.
Doubar had always been so much more than just a brother to him and even though the other man would just be an observer now his support and confidence – not only in his captain but also the young redhead who they all missed so dearly – meant more to him than he would have expected. And what was most remarkable about it was that, as he let his gaze stray to his friends who stood right next to the first mate, he could see the same kind of belief and trust in their eyes as well. Indeed it seemed none of them held even the shadow of a doubt and briefly Sinbad wondered whether their confidence was founded solely in him, or rather the Celt who had never really been absent from their lives. Deciding however that the answer to this unspoken question didn't matter he finally released a long and even breath before he broke the eye-contact he had with his friends and closed the gap on Chiara.
The young blonde looked up when eventually Sinbad reached the column, her blind eyes settling on his form instantly.
"The time has come, good Captain."
Her features were tense, her face now half-hidden in the shadows the fires behind them cast on her. Without taking her gaze off him she raised her right hand and as in that very instant the magical red light broke through the second Northern mark, she uttered:
"The time for blue flames to blaze!"
A/N: So that's part one. I have already started working on part two and am actually rather excited about it. I have been waiting to write that part and the following chapter (which would be number 15) for years (literally!) so now I'm rather looking forward to finally bringing my ideas down on 'paper'. Also I should have the next weekend off which might do for a great opportunity to sit down and write as much as I want. Thus, hopefully, the next instalment won't take me as long again! ;)
As always feedback is very much appreciated and guest review is enabled. =)


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10 Healthy Christmas Recipes: Blogger Edition
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Spice up your Chex party mix for the holidays with this Santa Hat Party Mix recipe. Using Bugle chips to form small Santa hats, this recipe is the perfect holiday treat for your guests. When you bring this mix to holiday parties, everyone will go nuts. This is such a creative recipe that will put a smile on everyone's face. If you want to make this party mix year-round, then simply omit the Santa hats.
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Meanwhile, the Speaker of the House circulated a memo to Republicans praising himself (can you believe this?) for leading America to the sequester, which he now owns, by his own pen.
Then, Rubio gave a speech to CPAC where he lacked the fortitude to even mention his No. 1 legislative priority: immigration (maybe the right won't find out about it).
And now ... Rubio continues his panderfest by joining Paul and Cruz in their filibuster against strong background checks. At the moment America is horrified to learn about the vast arsenal of another mass murderer of children, Rubio panders in favor of the arsenal!
Perhaps Mr. Ailes can create a new cable television show on Fox called "Marco, Ted and Rand." This would (pardon the pun) kill two birds with one stone. Rubio, Paul and Cruz can get their precious cable exposure, which seems to be their reason for everything, and we can leave the battles against mass murderers who kill children to the grown-ups who care about the kids.
As for BoehnerJohn BoehnerBoehner on Trump tweets: He gets 'into a pissing match with a skunk' every day Boehner predicts GOP will 'never' repeal, replace ObamaCare Sudan sanctions spur intense lobbying MORE, he has now claimed Republican ownership of the sequester with his strange message of self-praise for the strategy that enacted the sequester and protected the wealthiest Americans from paying their fair share of taxes. Upon this rock, Republicans will build their church, while Democrats will build their campaign to take back the House.


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Nancy Cartwright, Hunting Causes and Using Them: Approaches in Philosophy and Economics
- Nickolas Garrett
- 2 years ago
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1 Review of Nancy Cartwright, Hunting Causes and Using Them: Approaches in Philosophy and Economics Kevin D. Hoover Departments of Economics and Philosophy Duke University Box Durham, North Carolina January 2009
2 Hunting Causes and Using Them: Approaches in Philosophy and Economics. By Nancy Cartwright. Cambridge, U.K.: Cambridge University Press, pp. x Hardback IBSN $85.00; paperback $ For the past thirty years, Nancy Cartwright has been one of the most significant philosophers of science. Beginning with a focus on physics, she was at the forefront of the movement to use philosophy to help to understand the practices of physics as seen from the working physicists point of view rather than simply to pronounce on those practices from an Olympian, but perhaps irrelevant, perspective. Starting with her Nature s Capacities and Their Measurement (1989), she has steadily taken in a wider scope of sciences, including social sciences. In Cartwright s view, economics is not some poor stepchild to physics but a significant part of a complex world in which the sciences are not (as so often thought by philosophers, physical scientists, and economists alike) arranged in a clear hierarchy in which each of the special sciences is reducible to the more basic sciences physics forming the bedrock. Cartwright has also been a major player in the philosophical analysis of causation, a role that suits her turn towards economics, which has been undergoing a causal revival in, for example, the work of Granger in time-series econometrics, Heckman in microeconomic policy analysis, and the program of natural experiments in applied microeconomics. Given this background a new book by Nancy Cartwright particularly one that singles out economics in its subtitle is surely a welcome event. Hunting Causes and Using Them unfortunately represents a missed opportunity. It is not a systematic treatise but a compilation of occasional papers written with various particular and mainly philosophical targets in view. The papers have been too lightly 1
3 edited to form coherent chapters in a unified volume. They are frequently repetitive, and notation shifts from chapter to chapter. It is often difficult to appreciate fully the point of the chapter without the full context of the debates to which they originally contributed. They are heavy sledding for an economist not already immersed in those debates. Despite professing to seeing useful insights in various approaches, Cartwright s method is more critical than constructive. And she sometimes misunderstands the approaches that she criticizes. For example, I do not recognize my own position in her account of my analysis of causal order (chapter 14). She attributes causal judgments to me that straightforward application of the formal definitions of chapter 3 of my Causality in Macroeconomics (2001) contradict. This is unfortunate, as she is a deeply insightful philosopher with a rare connection to actual practice; and, even here, her discussion is full of genuine insights about causation and the problems of modeling it. A constructive treatise that tempered her criticism with a lucid exposition of its objects would have been exceedingly helpful. Three themes dominate Hunting Causes. The first is that cause is a plural concept. The methods and metaphysics of causation, she believes, are context dependent. Different causal accounts seem to be at odds with one another only because the same word means different things in different contexts. Every formal approach to causality uses a conceptual framework that is thinner than causal reality. She lists a bewildering variety of approaches to causation: probabilistic and Bayes-net accounts (of, for example, Patrick Suppes, Clive Granger, Wolfgang Spohn, Judea Pearl, Clark Glymour); modularity accounts (Pearl, James Woodward, Stephen LeRoy); invariance accounts (Woodward, David Hendry, Kevin Hoover); natural experiments (Herbert Simon, James 2
4 Hamilton, Cartwright); causal process accounts (Wesley Salmon, Philip Dowe); efficacy accounts (Hoover); counterfactual accounts (David Lewis, Hendry, Paul Holland, Donald Rubin); manipulationist accounts (Peter Menzies, Huw Price); and others. The lists of advocates of various accounts overlap. Nevertheless, she sometimes treats these accounts as if they were so different that it is not clear why they should be the subject of a single book. And she fails to explain what they have in common. If, as she apparently believes, they do not have a common essence, do they have a Wittgensteinian family resemblance? She fails to explore in any systematic way the complementarities among the different approaches for example, between invariance accounts, Bayes nets, and natural experiments that frequently make their advocates allies rather than opponents. The second theme is her distinction between schemes that deductively clinch causal inferences and those that inductively vouch for them. Her idea is that certain schemes of causal inference work by making such strong background assumptions that inductive arguments are turned into deductive arguments. She is surely right that many arguments take the form of clinchers, conditional on background assumptions. But she is wrong to imply that advocates of these forms of argument are insensitive to the tentativeness and the fallibility of those strong background assumptions. Such sensitivity means that arguments that take the form of clinchers are, in reality, always practically vouchers. For example, with Bayes-net approaches a statistical model describes data from which probabilities are inferred; and causal order, in turn, is inferred deductively from those probabilities. The inferences are based on strong assumptions. For instance, analysts frequently assume causal sufficiency (i.e., there are no omitted variables of a 3
5 type that would confuse causal inference), the acylicality of causal structure, and the linearity of functional relationships. Serious users of Bayes-net approaches are deeply aware of the fragility of the statistics both the quality of the data and the modeling assumptions (e.g., stationarity and homogeneity). And they are aware that the assumptions about causal structure may fail in practical cases, which is why they have investigated the implications of alternative assumptions e.g., latent variables (relaxing causal sufficiency), nonlinearity, and cyclical models. And what is the alternative? Absent the strategy of embedding clinchers within maintained, but criticizable, assumptions, Cartwright provides no account of how evidence vouches for causal claims. The final theme is the distinction between hunting and using causes highlighted in the title. The distinction gets it bite in Cartwright s belief that the strategies that successfully allow the identification of casual mechanisms frequently serve policy applications ill. Building on a longstanding theme of her work, real world processes are seen as the complex composition of a variety of deeper tendencies. The function of scientific experiments is to isolate those tendencies through stringent controls so that they can be exhibited in pure form. The application of scientific knowledge in practice is frequently complicated if not thwarted altogether because the real world is open and, unlike in the laboratory, the complicating tendencies are uncontrolled. In such cases, it is not necessarily reliable to infer that effects found under stringent controls will play out similarly in the world. Her insight trades on the old distinction between internal and external validity. For example, we may discover in a randomized controlled trial that a drug is effective 4
6 against the malaria parasite; and, yet, for a variety of social and biological reasons, the drug may prove to be practically ineffective in patients. One lesson, perhaps, is that randomized controlled trials need to be supplemented with epidemiological studies. The exact same issues can arise with respect to natural experiments in economics: can the mechanism that they isolate be carried over to other policy contexts? The theme of hunting versus using causes is elaborated in the final chapter on the use of counterfactuals in economics. Cartwright argues that the relevant counterfactuals isolate a cause from its own causes and set it to some value come what may. Using the same implementation-neutral strategies counterfactually to evaluate policies typically results in imposters the wrong counterfactual for the issue to hand. Genuine policy analysis typically, though not always, requires implementation-specific counterfactuals. (Not always because some policies need to be robust across different implementations if they are to be useful since, in some cases, targeting is practically restricted.) Cartwright is clearly correct that good policy requires the right counterfactuals and that, naturally, economists sometimes get it wrong. Yet, as a generic criticism, her case is not persuasive. For example, a straightforward reading of the Lucas critique, which Cartwright cites in other parts of the book with other purposes, is precisely as a plea for understanding counterfactuals in a causally structured, implementation-specific manner. Implementation of policy requires the specification of conditional rules and not a come-what-may setting of particular variables. Nancy Cartwright has once again written an intellectually challenging book, full of insights. It is too bad that the presentation is not well adapted to an audience of 5
7 econometricians and applied economists, for whom the issues that she considers are important and not always clearly thought through. 6
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Tear Drop Necklace in Moonstone
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