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Written By: Bastian Solutions
Having a solid business development plan and lead management strategy are key to growing your business.
A couple weeks ago, I read a great article in Fabricating & Metalworking Magazine titled, "Staying One Up: New Ways of Doing Business." The author, Mike Riley, discussed several ways in which companies could get a step up on their competition.
Although his article was aimed at marketing initiatives in the metalworking industry, many of his points were relevant to new business development (NBD) in material handling and other industrial sectors. Looking at a few of Riley's key points, I was able to build some helpful insights for improving business development in the coming year.
Riley — "Put your marketing under the microscope."
I would suggest taking Riley's point one step further by not only placing your marketing under the microscope but also your operational activities. Ensure you are a customer-centric company. Once this is done, efforts can be focused on better understanding each, unique business opportunity. This means focusing on connecting with potential repeat customers on a personal and emotional level. Companies that have grown to annual multi-billion dollar revenues have learned how important it is to connect with the client early on, and those companies will continue to grow as a result.
Riley — "Seek presentation opportunities."
When it comes to new business development, Riley's point is an excellent way to get your foot in the door, but once you are presenting, make sure to be creative, well-spoken, and not overly geared toward selling. Following these guidelines will result in a presentation the client will enjoy and appreciate.
Before Steve Jobs passed away, he embraced the 10/20/30 rule in regards to PowerPoint presentations. This means for an introductory presentation 10 slides, no more than 20 minutes of PowerPoint, and size 30 fonts for text. Some presenters simply believe in using pictures or renderings as entire slides instead of using bulleted text. The idea is to converse and tell a story keeping in mind the goal is to create interest in doing business with your company rather than forcing people to believe that you are their best option.
Riley — "Piggyback on hot news."
Staying on top of the latest news is important, but in the material handling world, as in many industries, it's important to stay abreast of the latest technologies and industry-specific news as well. In terms of new business development, figuring out what everyone is talking about and interested in gives you a much better idea of how to appeal to the needs, concerns, and wants of new clients. Find a way to read into the cutting edge topics, and make them relevant to what you can offer.
Riley — "Develop a prospect database."
Not only should companies develop a prospect database, they should make sure it is accurate and up-to-date. A database does no good if the information is outdated or incorrect.
There should also be a sales lead accountability system. According to Pew Research statistics, up to 80% of sales leads that come into any given company without a lead manager are lost. That is why it is so important to have a method of following up. It is imperative to enter information into a customer relationship management (CRM) tool and set reminders to follow up with new clients.
It doesn't matter if you design material handling systems, manufacture products, or run a distribution center. Whatever field you are in, never be content or satisfied with your existing business. There are always ways to improve and attract new clients. Always be honest, polite, and respectful of your prospects, and ask yourself, "Why do I deserve more business?"
Your email address will not be published.
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1/4" to 3/8" Tripod Thread Adapter Screw
This 3/8" to 1/4" Thread Adapter converts a standard 1/4-20 thread size to a larger 3/8-16
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Our Tripod Thread Adapters a slightly longer than other 3/8"-16 to 1/4"-20 adapters, making them far more secure and providing a stronger mounting.
Perfect for DIY projects.

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Tutorial not found. Let know us about any useful video tutorial.
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Completely renewed software. New algorithms, interface etc.


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I Love brand Crush... i can't deny that!!
BUT Crush no longer includes RootBeer in their rainbow pack, and that is upsetting!!
For years my family has purchased the rainbow pack, and now that i'am an adult purchasing it for my kids/family, it's just not the same!
Orange, Cream Soda, and Grape are the only pop now offered in the Crush rainbow pack.. and if i want Rootbeer then i must buy separately.
My Opinion: Bring Back RootBeer in their Rainbow Packs!
Otherwise, everything else about Crush, I Love!!!
These reviews are the subjective opinions of ChickAdvisor members and not of ChickAdvisor Inc.


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Doctor insights on:
Abdominal Wall Tear Symptoms
Is loosing weight initially associated with early symptom of ingenuial hernia? When abdominal wall weakens does blood test show anything?
Hernias: Hernias can protrude with weight loss. The fat that was plugging the opening may shrink and allow fat or abdominal organs to protrude. You should start with a physical exam to see if your hernia can be felt. A general surgeon or general internist can examine you. If it is small, an ultrasound or ct scan can image the hernia. Blood tests will not help. ...Read more
Opening on abdominal wall for colostomy, what happens?
Usually nothing: The opening on the abdominal wall is small and just large enough for the colostomy to fit. The edges of the colostomy are then tacked down to the surrounding skin to seal the area. Rarely does anything go wrong. Occassionally there might be a paracolostomy hernia that then needs repair or a prolapse or dropping out of the colostomy itself that needs to be fixed. ...Read more
Sprained abdominal wall what helps?
Rest: Rest, time, heat, stretching, pt.Get a more detailed answer ›
What's the medical term for a weak abdominal wall?
Diastasis recti: Diastasis recti (also known as abdominal separation) is a disorder defined as a separation of the rectus abdominis muscle into right and left halves. Normally, the two sides of the muscle are joined at the linea alba at the body midline. It is essentially a cosmetic condition, with no associated morbidity or mortality. ...Read more
What one expert should we see if they suspect abdominal wall defect in our fetus?
Perinatologist: First start with a perinatologist (maternal-fetal medicine specialist). They'll screen the infant for other birth defects and/or chromosomal problems. Depending on what they find, they'll coordinate delivery with a pediatric surgeon if needed & a neonatologist. But first start with a good mfm specialist. Best wishes to you. ...Read moreSee 1 more doctor answer
I have been having a sharp pain in the lower right side of my abdomin. I was told that i might have abdominal wall pain. What exactlly is this?
Muscular Pain: The abdominal wall consists of multiple muscle layers. Like anywhere on the body, a pulled muscle can cause significant, lingering pain. Since we use our core muscles for most activities, it can be difficult to rest these muscles. Pain from the abdominal wall can be difficult to distinguish from "internal" abdominal organ pain; muscular pain tends to be unrelated to food & worsened by activity. ...Read more
Are there exercises which strengthens the abdominal wall and which can help against developing a hernia in first place?
No: Many people with strong abdominal muscles get hernias, and many people with weaker muscles don't have hernias. There is most likely a genetic predisposition to hernia formation based on the types of connective tissue that any given individual has. Keep exercising though, its great for lots of other things! ...Read moreSee 1 more doctor answer
Why would someone need an abdominal X-ray and an "echo of the back abdominal wall'?
Abdominal symptoms: The tests of abdominal xray and "echo" of the back of the abdominal wall (probably abdominal ultrasound) are typically used to evaluate abdominal symptoms or concerns. The xray can provide information on the status of bowel distension, presence of stones, etc, and the abdominal ultrasound can provide info on kidney, liver, gallbladder, pelvic organs, etc. ...Read more
I coughed so hard i tore my abdominal wall and caused a hematoma.Two weeks later and still in a lot of pain. How long till pain goes away...
Strain: Severe strain with tearing of muscle fibers may take a little longer to heal. Rib fractures can also occur with hard coughing. At this time I would try intermittent heat to the area which may help the healing process. Hold onto the injured area if you must cough or sneeze and avoid other strain as well. ...Read more
How does wearing an abdominal binder help resolve a seroma and a weak spot in the abdominal wall?
Resolve with time: Most of the seromas due to surgery especially after incisional hernias repaired with mesh will resolve with or with out abdominal binder binders make some comfortable in others will inter fear with breathing. ...Read more
- Talk to a doctor live online for free
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- Ask a doctor a question free online
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- Abdominal muscle tear symptoms
- Tear in uterine wall
- Indentation in abdominal wall
- Abdominal wall muscle tear


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It's that time again. Where some of my followers are turned into prize winners.
If you see your name here then please check your emails.
Their Nibs – Janet Bagnall, Lynn Neal
Paint sticks – Wendy J Jones
Cleaning hamper – Laura Jones
It's time to announce a few winners once again, so a big congratulations to the following people!
Teletubbies DVD – Lara Latchem, Sarah Ann, Jayne Towsen
Guardians of Oz DVD – Michelle O'Neil, Rachael Ashmore, Marie Miles
Mindful chef – Julie Smith
Charlie Doodle – Tee Simpson
If you see your name above, please check your emails for a notification.
"Eye Fly High"
Tales about a family of 6 with teens, a tween & a toddler
Subscription Box Reviews, Active Directory, Spoilers, New Box Releases, Coupons and Lots of Nonsense.
Welcome to the Fox's den. Musings by Carmen Fox.
A childhood Experience.
Australian criminals and their Crimes. Con artists, scum bags, murderers, corrupt cops, pollies, rapists and paedophiles will find themselves in this blog. It was expanded to also cover those that ought to be charged for their idiotic disgusting behaviour. Usually high-profile people who think they are above the law
A Gale of two cities . . .
Seasoning while rocking out since 1983
Losing it, One Marble At A Time
Drug expert Mary Microgram answers your burning questions.
For real parents everywhere
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Life, Leisure, Luxury
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The Brief Wondrous Life of Oscar Wao
The Brief Wondrous Life of Oscar Wao
By Junot Diaz
Riverhead Books, Hardcover, 9781594489587, 339pp.
Publication Date: September 6, 2007
List Price: $26.00*
* Individual store prices may vary.
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Winner of:
The Pulitzer Prize
The National Book Critics Circle Award
The Anisfield-Wolf Book Award
The Jon Sargent, Sr. First Novel Prize
A Time Magazine #1 Fiction Book of the Year
Oscar is a sweet but disastrously overweight, lovesick Dominican ghetto nerd. From his home in New Jersey, where he lives with his old-world mother and rebellious sister, Oscar dreams of becoming the Dominican J. R. R. Tolkien and, most of all, of finding love. But he may never get what he wants, thanks to the Fuku--the curse that has haunted Oscar's family for generations, dooming them to prison, torture, tragic accidents, and, above all, ill-starred love. Oscar, still waiting for his first kiss, is just its most recent victim.
Diaz immerses us in the tumultuous life of Oscar and the history of the family at large, rendering with genuine warmth and dazzling energy, humor, and insight the Dominican-American experience, and, ultimately, the endless human capacity to persevere in the face of heartbreak and loss. A true literary triumph, The Brief Wondrous Life of Oscar Wao confirms Junot Diaz as one of the best and most exciting voices of our time.
About the Author
Junot Diaz's fiction has appeared in The New Yorker, The Paris Review, and The Best American Short Stories. His highly-anticipated first novel, The Brief Wondrous Life of Oscar Wao, was greeted with rapturous reviews, including Michiko Kakutani in The New York Times calling it "a book that decisively establishes him as one of contemporary fiction's most distinctive and irresistible new voices." His debut story collection, Drown, published eleven years prior to Oscar Wao, was also met with unprecedented acclaim; it became a national bestseller, won numerous awards, and has since grown into a landmark of contemporary literature. Born in the Dominican Republic and raised in New Jersey, Diaz lives in New York City and is a professor of creative writing at MIT.


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Big Ten Tournament 2016
With 22 wins, four over top-25 teams, and a good showing in a strong Big Ten Tournament, the Wolverines feel that they belong in the NCAA Tournament.
With one last chance to come back in Michigan's one last opportunity to secure an NCAA Tournament bid, Walton — who had been 0 for 11 shooting through two and a half games in the Big Ten Tournament — led the charge. It was ultimately a futile effort, but Walton's growth was unmistakeable.
Michigan put up a fight against Purdue in Indianapolis on Saturday afternoon, but fell short down the stretch with its NCAA future hanging in the balance.
Watch the videos to see Muhammad-Ali Abdur-Rahkman, Ricky Doyle and Mark Donnal break down what went wrong, and where the team goes from here.
John Beilein, Derrick Walton and Muhammad-Ali Abdur-Rahkman were on the podium after Michigan fell to Purdue in the Big Ten Tournament semifinals. Walton gave Michigan an inspired effort with 14 points, 6 rebounds, 5 assists and 3 steals while Abdur-Rahkman added a team-high 15 points.
After falling to No. 13 Purdue, the Michigan basketball team's postseason destiny hangs in the balance. The Wolverines (10-8 Big Ten, 22-12 overall) fell behind early, and were unable to keep up with the Boilermakers' post presence.
Watch the videos to see Zak Irvin, Derrick Walton Jr., Kam Chatman and Andrew Dakich break down what went wrong against the Boilermakers.
Dominated in the post and unable to counter offensively, Michigan put its NCAA Tournament bid in jeopardy with a 76-59 loss to No. 13 Purdue. The result advanced the Boilermakers (12-6 Big Ten, 26-7 overall) into Sunday's championship, while the Wolverines (10-8, 22-12) are left waiting for Selection Sunday to decide their fate.
Michigan's season has new life after yesterday's win over Indiana and the Wolverines will be looking to parlay that momentum into a trip to the Big Ten Tournament Championship Game.
The Boilermakers are 5-1 since their loss in Ann Arbor, including wins over Maryland and Wisconsin. Now, they have a chance to avenge the game that slipped away, and advance to the Big Ten Tournament finals too.
Michigan is looking for its third win in three days as it gets set to face Purdue just 24 hours after its buzzer-beating win over Indiana on Friday.


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- $14 for a haircut and style ($28 value)
- $49 for full foil highlights, haircut and style ($93 value)
Both options may be used for men, women, or children.
Kenneth's Academy Hair Salon
The stylists at Kenneth's Academy Hair Salon take a lot of pride in their work. And why wouldn't they? The company—which has 11 salons and three dedicated day spas in the Columbus area—is entirely employee owned, meaning the salon professionals have added incentive to ensure every cut, color, manicure, facial and massage is performed flawlessly. Perhaps that's why the company has racked up numerous awards from both local and national publications.
The Academy location hosts stylists that are licensed cosmetologists who have completed an intensive year-long training program. During this time, each stylist has completed at least 500 apprentice hours under Kenneth's top stylists, at least 500 in-class hours with educators and practiced services on over 100 models.


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UI Consolidation
To address crowding in our header menu and to leave room for upcoming features, we decided to utilize a couple drop-down menus. We hope you like them!
Here's the old look:
And the new:
(The user icon comes from Gravatar, for those of you who aren't already initiated.)
Stay tuned for other improvements that Jina and I are polishing up. Thanks!


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Product Spotlight
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Valero Adopts New Compensation Policies
A say-on-pay policy will allow shareholders to provide feedback on executive compensation.
SAN ANTONIO -- Major energy company Valero Energy Corp.'s board of directors recently adopted a say-on-pay policy, a compensation consultant disclosure policy and other policies to enhance the company's corporate governance program.
Under the new say-on-pay policy, stockholders will be provided with an advisory vote on executive compensation, starting with the company's 2010 annual meeting, according to the company.
"Our executive compensation programs are designed to attract and retain the executive talent necessary to be successful and to align the executives' financial rewards with the growth and success of the company, promoting long-term, positive results for our stockholders," said Bill Klesse, Valero chairman of the board and CEO, said in a statement. "The say-on-pay policy will provide stockholders an opportunity to provide feedback to our board and management about our executive compensation programs."
The compensation consultant disclosure policy provides for annual disclosure in Valero's proxy statement regarding fees paid to Valero's compensation consultant, and is designed to assist stockholders in the assessment of the independence of the consultant, the company stated.
In addition, the company's board approved an executive compensation recovery policy, or "clawback" policy, as well as a political contributions disclosure policy.
"Valero has always been committed to high standards of corporate governance," added Klesse. "By adopting these policies, Valero has also demonstrated its commitment to improving its governance program to strengthen investor confidence, increase long-term stockholder value and be responsive to the views of stockholders as best practices in corporate governance evolve."
Related News:
BP's 3Q Profit Beats Estimate; Valero's 3Q Brings Net Loss of $579 Million


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Boolean network inference from time series data incorporating prior biological knowledge
Selected articles from the IEEE International Workshop on Genomic Signal Processing and Statistics (GENSIPS) 2011
IEEE International Workshop on Genomic Signal Processing and Statistics (GENSIPS) 2011
Numerous approaches exist for modeling of genetic regulatory networks (GRNs) but the low sampling rates often employed in biological studies prevents the inference of detailed models from experimental data. In this paper, we analyze the issues involved in estimating a model of a GRN from single cell line time series data with limited time points.
We present an inference approach for a Boolean Network (BN) model of a GRN from limited transcriptomic or proteomic time series data based on prior biological knowledge of connectivity, constraints on attractor structure and robust design. We applied our inference approach to 6 time point transcriptomic data on Human Mammary Epithelial Cell line (HMEC) after application of Epidermal Growth Factor (EGF) and generated a BN with a plausible biological structure satisfying the data. We further defined and applied a similarity measure to compare synthetic BNs and BNs generated through the proposed approach constructed from transitions of various paths of the synthetic BNs. We have also compared the performance of our algorithm with two existing BN inference algorithms.
Through theoretical analysis and simulations, we showed the rarity of arriving at a BN from limited time series data with plausible biological structure using random connectivity and absence of structure in data. The framework when applied to experimental data and data generated from synthetic BNs were able to estimate BNs with high similarity scores. Comparison with existing BN inference algorithms showed the better performance of our proposed algorithm for limited time series data. The proposed framework can also be applied to optimize the connectivity of a GRN from experimental data when the prior biological knowledge on regulators is limited or not unique.
Technological advances in the last two decades have provided numerous approaches to measure various aspects of the regulome in a cell. However, the data generated for specific conditions are still limited both in terms of number of time points and number of samples. Models of genetic regulatory network (GRN) are regularly being inferred from limited time series data on average tissue expression as measured by technologies such as microarray. Selection of a mathematical model to represent a GRN and its inference from limited noisy time series data remains an important problem in systems biology.
The foremost aspect of inference of a mathematical model for explaining a regulatory process is selection of the model. A comprehensive model can provide an accurate picture of the regulation assuming that the parameters of such a model can be correctly inferred. However, we are often faced with limitations on the experimental data which motivates us to design simpler models with the ability to capture the coarse-scale dynamics of the GRN. In this paper, we consider cases where there are only one set of time series transcriptomic or proteomic data generated from a cell line after a specific perturbation. Here, we are considering cell population averaged data as measured by techniques such as microarrays and thus we will start with a deterministic model explaining the average behavior of the system. For a deterministic model, common choices will be Differential Equation (DE) or Boolean Network (BN) type of models. Inference of the parameters of a DE model from minimal data can produce unreliable models as was observed when we tried to infer commonly used linear and non-linear DE models
Our goal in this paper is to provide a BN inference approach from limited time series data and prior biological knowledge on connectivity. The proposed framework can also be applied to optimize the connectivity of a GRN from experimental data when the prior biological knowledge on regulators is limited or not unique. Our analysis will reveal that the chances of generating a BN with small length attractor cycles and satisfying the observed transitions with constraints on connectivity is extremely rare if the regulators of a gene are selected randomly and the data itself lacks structure. We apply our inference approach on time series transcriptomic data of 6 genes and 6 time points from an HMEC cell line following application of epidermal growth factor (EGF) and were able to generate a BN with a biologically plausible singleton attractor structure and satisfying the experimentally observed transitions. The theoretical analysis shows that the generation of such a network from 6 random state transitions and random selection of 3 regulators of every gene is extremely low which in turns suggests that there is structure in the biological data that is exploited by our inference algorithm to arrive at a biologically plausible BN. We next set up an experimental design to compare synthetic BNs with BNs generated through our framework based on state transitions from the synthetic BNs. The results illustrate the capability of the proposed inference technique to generate BNs that are similar to the original BNs by using few state transitions when the connectivity is known.
The paper is organized as follows: The 'methods' section contains (a) a review of BNs and the biologically motivated assumptions and constraints that will be imposed during inference, (b) theoretical analysis of the search space for the inverse problem and (c) Inference Algorithm. The 'results' section contains the results of applying the framework to experimental HMEC data and synthetic BNs; results of comparison with 2 other approaches is also discussed in this section. Further analysis of the results are included in the 'conclusions' section.
GRN model and modeling assumptions
A Boolean network (BN) B = (V, F) on
The biologically motivated assumptions and constraints that we will impose are:
(i) Biological networks usually have sparsity in their connectivity structure. Thus we will restrict our connectivity to
(ii) Biological networks are usually robust to perturbations and can produce a reproducible trait under changing conditions. The robustness of an inferred model will be measured in terms of coherency of the BN
(iii) GRNs usually have small attractor cycles and thus any oscillation observed in our data should be reflected in the Boolean model as a limited state attractor cycle.
(iv) Among two feasible functions, the one with lower inconsistency will be selected. Here, inconsistency refers to same state of the predictor state producing different target output. Let us consider that we have
Search space analysis
In this section, we will analyze the size of the search space for the inverse problem of inferring a Boolean model of a GRN from time series data based on connectivity and structural constraints.
Let us consider the case of experimental data of
Table 1
Illustration of the number of possible BNs with no constraints on connectivity
When we restrict the connectivity to
Table 2
Illustration of number of possible BNs with constraints on connectivity
←n = 1
←n = 2
←n = 3
Without restriction on connectivity, knowledge of
Similarly it can be shown that the probability of hitting a unique place at the 4th transition is
In general, we can say that the probability of hitting a unique place at the
We next consider the expected number of distinct transitions required to fill up (
Another characteristic of a BN that is desirable from a biological perspective is lack of large length attractor cycles
Inference algorithm
Our propsoed BN inference algorithm is as follows:
Algorithm 1 Algorithm for Calculating the Score of a BN
Calculate the transitions in the generated BN from state
Score = Score +
end for
We used transcriptomic and proteomic time series data generated by Rogers
Figure 1
Pathway of the 6 genes generated from literature search
Pathway of the 6 genes generated from literature search.
For the 6 genes
Figure 2
State transition diagram of the inferred BN
State transition diagram of the inferred BN.
Figure 3
State transition diagram of the BN inferred using random connectivity
State transition diagram of the BN inferred using random connectivity.
Validation with synthetic network models
In the previous section, we showed the result of our inference approach when applied to experimental data. Since the true structure of the Boolean Network for the
Algorithm 2 Algorithm for Calculating Similarity Measure of Two Different BNs
for i = 1:NumPath do
Calculate the transitions in the generated
Score(i) = Score(i)+
end for
end if
end for
For example, if we take Figure
Figure 4
Figure 5
If we analyze the structure of Figure
For example, if we use Figure
Figure 6
Figure 7
Figure 8
Figure 9
Table 3
Similarity ratios for BNs inferred from data generated from Fig 6
1 path
2 paths
3 paths
We also considered numerous other BNs with at least 4 attractors as the
For the results reported in Figures
Table 4
Similarity ratios for BNs inferred from data generated from Fig 6 with random predictor set
1 path
2 paths
3 paths
Comparison with existing BN inference approaches
We compared the performance of our proposed algorithm with (a) Liang
Comparison with REVEAL
REVEAL is a well-known reverse engineering algorithm for inference of genetic regulatory architectures proposed by Liang
We've implemented REVEAL algorithm in MATLAB. For convenience of comparison between our approach and REVEAL, we've used synthetic BN where the original regulators and functions are known. We've used our algorithm to infer the BN with maximum similarity ratio (
Figure 10
Comparison with MDL approach
As we're trying to find a deterministic Boolean network, we've binarized the gene expression based on a conditional probability threshold of 0.5. For example, let's assume that there are 3 genes (
Similar to the comparison technique with REVEAL, we've used the same path from
Figure 11
Other than the performance with respect to similarity ratio, our approach performs better than both of REVEAL and MDL approaches in elucidating the attractors. Our results also support the claim in Zhao
In systems biology, we are often faced with the issue of reverse engineering a GRN model from limited time series data. This article proposes an inference approach utilizing prior biological knowledge of connectivity to generate a BN with biologically plausible state transition structure and explaining the observed transitions in the data. The proposed framework can also be applied to optimize the connectivity of a GRN from experimental data when the prior biological knowledge on regulators is limited or not unique. We validated our algorithm based on experimental data of HMEC cell line and data generated from synthetic BNs with known state transition structure. Through theoretical analysis and simulations, we were able to illustrate that inference of a BN from limited time series data with constraints on connectivity that explains the observed state transitions, is extremely rare if we consider random connectivity. High performance of our proposed algorithm as compared to existing BN inference algorithms that depend on inference of connectivity from the data, further support the advantage of using prior biological knowledge on connectivity. Thus, for cases of limited experimental data, the prior biological knowledge of connectivity should be utilized to arrive at robust BNs with biologically plausible state transition structures. For future research, we will consider combining transcriptomic and proteomic data to reduce the inconsistencies in the data. One of the significant challenges in combined analysis will be the different degradation times for mRNA and proteins.
List of abbreviations used
BN: Boolean Network; DE: Differential Equation; GRN: Genetic Regulatory Network; EGF: Epidermal growth factor; HMEC: Human Mammary Epithelial Cell; MDL: Minimum Description Length.
Competing interests
The authors declare that they have no competing interests.
Authors' contributions
Conceived and Designed the Experiments: SH RP. Performed the Experiments: SH. Analyzed the Results: SH RP. Wrote the article: SH RP. All authors read and approved the final manuscript.
Based on "Inference of a genetic regulatory network model from limited time series data", by Saad Haider and Ranadip Pal which appeared in
This work was supported by NSF grant CCF 0953366.
This article has been published as part of
Improved Reconstruction of In Silico Gene Regulatory Networks by Integrating Knockout and Perturbation Data
Oscillatory behavior in enzymatic control processes
Genomic regulation modeled as a network with basins of attraction
Mathematical modeling as a tool for investigating cell cycle control networks
An information theoretic approach to constructing robust Boolean gene regulatory networks
Understanding robustness in random Boolean networks
Generating Boolean Networks with a Prescribed Attractor Structure
Investigating the correspondence between transcriptomic and proteomic expression profiles using coupled cluster models
Culture systems for study of human mammary epithelial cell proliferation, differentiation and transformation
A threshold selection method from gray-level histograms
Epidermal Growth Factor Receptor Stimulation Activates the RNA Binding Protein CUG-BP1 and Increases Expression of
From biological pathway to regulatorynetworks
Reveal, a general reverse engineering algorithm for inference of genetic network architectures
Inferring gene regulatory networks from time series data using the minimum description length principle
Inference of a genetic regulatory network model from limited time series data


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RegExp@News allows you to search through newsgroup articles with regular expressions. The whole process of specifiying the newsgroups, expressions, editing the personal preferences, viewing the found articles, and so on can be accomplished via a Web frontend. The system is also able to send found articles to the users by email. The users can select the newsgroups and expressions to be used in the search, as well as when they want to receive the found articles by email. All data are stored in a MySQL database. The article fetching and processing backend is built with Perl, and the Web frontend is built with Apache and PHP.
Knewspost is a KDE frontend to newspost, a Usenet binary autoposter for Unix. It provides a graphical environment for autoposting binaries to newsgroups. It features tooltips for ease of use, post list creation, saving default values to a file, posting status window, and post log saving.
Newsstar fetches news and posts it to a local news server: INN, s-news, and sn are supported. What makes newsstar special is that it can make multiple simultaneous connections, not only to one server, but to several, supporting up to 10 "threads". Before fetching each article, it checks that it hasn't already been downloaded by another thread or in a previous session. It can also "pipeline" article requests to make better use of available bandwidth. SSL is supported.
Juta (Java Usenet Traffic Analyzer) is a Java (1.2 or higher) command line program that reads a text file with Usenet postings, and creates an HTML file with statistical information of those postings. This includes a list of the longest threads, authors with most postings, operating systems and newsclients used, and more. The inclusion of person-related information can be turned off to ensure privacy. The program is distributed as an executable JAR that also contains the source code. Also included in the distribution are several tools to process news postings: sort and count them, remove duplicates, list information on postings, grep and filter them.


text:
Undecided Students
Undecided students should try to learn more about themselves, the world of work, and what Suffolk County Community College has to offer.
If you are undecided, we suggest that you:
If you are undecided, we suggest that you:
- Read the college catalog for descriptions of the different curricula and programs available.
- Use electives to take survey or introductory courses in your areas of interest.
- Go to the Counseling Center for career counseling, interest testing, and access to computerized career decision-making systems.
- Learn about the job market, employment trends, and specific career areas by:
- talking to the career services counselor on your campus;
- reviewing the Occupational Outlook Handbook and other career-related materials available in the Counseling Center or any library; and
- exploring the college's Career Services Web site with its many links to educational, career, and occupational information.
- Explore clubs, organizations, and co-curricular activities available on campus
(i.e., especially those related to your areas of interest).
- Get some work experience (i.e., part-time, full-time, summer, seasonal, work-study, internships, co-op, etc.) in your areas of interest.
- Talk to advanced students who are majoring in the areas you are considering.
- Talk to department heads, program coordinators, and faculty in all the major areas you are considering.
- Talk to people currently employed in the areas you are considering.
Last revised: 4/19/2011 Comments on this webpage, contact: Webmaster


text:
- For others with the same surname, see al'Caar.
Nela al'Caar is a Two Rivers resident.
Appearance Edit
She is long-faced with a long gray braid.
Activities Edit
During Nynaeve al'Meara's testing for Accepted, she sees a version of Nela who has become unstable from grief due to her husband's and sons' death.[1]
Perrin Aybara helps her to organize the children before the Trolloc attack.[2]


text:
Telecoms engineer Lead to Cash & FTTP
- Recruiter
- Fusion People
- Location
- Reading
- Salary
- £120.00 per day
- Posted
- 29 Sep 2016
- Closes
- 23 Oct 2016
- Sector
- Engineering
Field Engineer L2C 'Lead to Cash & FTTP' BT Openreach contractors/freelancers:- These skills are deployed across all areas of the access network and cover functions such as civils, cabling, jointing, poling and maintenance of BT's physical network and its associated assets. Our strategy is to excel in delivering our Openreach customer's requirements and use this model as a base for further growth in the Telecoms Industry. Role Profile: Optical Splicing Engineer tasked by Supervisor or Field Manager to Install, splice and test fibre bundles in line with contract requirements for Openreach Lead to Cash program. BT Accreditation is essential but full training could be given for the correct candidate. FTTP / PON experience is an advantage but not essential as some training and accreditations will be given. The successful candidate should be able to working as part of a team but working alone without the need for direct on site supervision plays a keep part of the role. Rates: £120 per day, Company Van, Fuel Card, and all Tools and equipment are supplied Typical Deliverables: Operation of optical fibre splicer and accurate results ensuring all are correctly documented. Installation of optical fibre cable, bundles and blown fibre tubing using fibre blowing equipment to required standards of quality and time. This may include fault finding and rectification on existing network. Splicing and testing of external optical fibres to the end customer premise in line with time and quality standards. Installation of sub-duct and micro-duct in existing underground trackway if needed. Maintain full compliance with all relevant EHS policies and procedures. Accurate and timely completion and submission of all required site administration and completion documents as required. Complete QC checks on own work and that completed by others on site and record results accurately using the correct documents. Accurate and timely submission of all payroll data and expense claims in accordance with published processes. Complete general risk assessment prior to commencement of each task on site and record in site diary. Maintain adequate and 'in date' personal protective equipment sufficient for all tasks undertaken and ensure that it is used as required at all times. Manage all personal issue tooling and test equipment in line with published processes to ensure that fit for purpose, calibrated and PAT tested tooling and test equipment is available as appropriate to complete all assigned tasks. Efficient management of all on-hire equipment ensuring items are returned promptly after use to minimise cost. Local primary point of reference for telent management and customer's representatives. Reporting to supervisor, Field Manager or Depot Manager on contract progress and completion. Knowledge, understanding and enforcement of all Openreach Policy, Processes and Procedures relating to installation activities. Care and maintenance of company vehicle and be fully compliant with all relevant driver policies. Business Operations Skills - Experience: Proven experience in an external fibre jointing and testing role. Preferably on the BT Network. Proven knowledge of health and safety and best working practices. Business Operations Skills - Qualifications: Accreditations must include: A8 Overhead Safety, A9 Underground Safety, Confined Spaces, E1 Dropwire & Overhead Techniques, J1 External Fibre Quality, J4 Optical Fibre Customer Premises, N8 FTTP Manifold construction, N9 FTTP (Tyco) Jointing and fibre Management, N15 32 FDP Prysmian, N16 Pole mounted FDP. Has current valid NRSWA Unit 2 operative accreditation. If you feel this role is for you please contact Louis Taylor on 0121 616 7150 or email on - Fusion People are committed to promoting equal opportunities to people regardless of age, gender, religion, belief, race, sexuality or disability. We operate as an employment agency and employment business. You'll find a wide selection of vacancies on our website. This job was originally posted as www.totaljobs.com/job/66753699


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China's first rate cut in more than two years has sent shares in Australia's iron ore miners surging higher, with the prospect of lower lending rates expected to boost the ailing housing construction sector in the world's second largest economy.
Iron ore pure-play
The Chinese government's decision to loosen monetary policy and stimulate its economy came as a surprise to most market pundits who were expecting policy makers to remain conservative.
Last week, data from China's National Bureau of Statistics showed that the average price of new homes across 69 of 70 Chinese cities measured slumped for the sixth straight month in October.
In the year to October, prices fell across 67 of 70 cities.
China's residential housing sector accounts for close to 25 per cent of steel consumption in the country. A rate cut, and some loosening of lending conditions is expected to help stimulate the sector again. Should the rate of growth in China's steel consumption begin to rise again, the price of iron ore is likely to rise in tandem.
On Friday, the price of iron ore measured out of the Qingdao port in China fell 0.9 per cent to $US70.31 per tonne, according to Metals Bulletin. Iron ore has slumped close to 48 per cent this year.
The announcement by the People's Bank of China was made after the local market closed, so the price of iron ore, determined by gathering of sale data after market close and updated once daily, has not yet been affected.


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Discover the mythical world of Nihilumbra and join Born on his adventure to find himself whilst trying to escape from his inevitable curse.
Born was created from the absolute nothingness: The Void. But somehow he separates himself from the black emptiness and appears in the real world. This is the start of his long odyssey, in which he will learn how to use the colors around him to gain powerful skills and change the world.
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[GAME CACHE] [222.8 MB] [v2.4]
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|Specific References
|Related Products
|Human Cells transfected lysate in which Mouse Ephrin B3 / EFNB3 has been over-expressed. The whole cell lysate is provided in 1X Sample Buffer (1X modified RIPA buffer+1X SDS sample buffer).
|Cell lysate was prepared by homogenization in ice-cold modified RIPA Lysis Buffer with cocktail of protease inhibitors (Sigma). Cell debris was removed by centrifugation. Protein concentration was determined with Bradford assay (Bio-Rad protein assay, Microplate Standard assay). The cell lysate was boiled for 5 minutes in 1 x SDS sample buffer (50 mM Tris-HCl pH 6.8, 12.5% glycerol, 1% sodium dodecylsulfate, 0.01% bromophenol blue) containing 5% b-mercaptoethanol, and lyophilized.
|Modified RIPA Lysis Buffer: 50 mM Tris-HCl pH 7.4, 150 mM NaCl, 1mM EDTA, 1% Triton X-100, 0.1% SDS, 1% Sodium deoxycholate, 1mM PMSF
|12.5% SDS-PAGE Stained with Coomassie Blue
|Samples are stable for up to twelve months from date of receipt at -80℃
|1. Centrifuge the tube for a few seconds and ensure the pellet at the bottom of the tube. 2. Re-dissolve the pellet using 200μL pure water and boiled for 2-5 min. 3. Store it at -80℃. Recommend to aliquot the cell lysate into smaller quantities for optimal storage. Avoid repeated freeze-thaw cycles. Notes:The lysate is ready to load on SDS-PAGE for Western blot application. If dissociating conditions are required, add reducing agent prior to heating.
|In modified RIPA Lysis Buffer
|Store at -80℃. Aliquot to avoid repeated freezing and thawing
|WB: Use at an assay dependent dilution.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Ephrin B3 belongs to the ephrin family. Ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. Ephrin B3 is important in brain development as well as in its maintenance. It is especially important for forebrain function since its expression levels were particularly high in several forebrain subregions compared to other brain subregions. Ephrin B3 binds to, and induce the collapse of, commissural axons/growth cones in vitro. It may play a role in constraining the orientation of longitudinally projecting axons.


text:
Its what Im listening to right now its one of the best albums thats been released this year. I must also confess I only caught up with them on this album, but if you looking to expand your pallet beyond hip hop get their album Ego Trip.
Tag: EgoDeath
Total 1 Post


text:
Vortex shedding and aeroelastic flutter question
Hi all,
I was wondering if vortex shedding alternating pressures ober bluff bodies is the cause of flutter, for example in plane wings or oder slim objects, or aeroelastic flutter has nothing to do with vortex shedding. I'm a bit consfused...
By the way, is it possible to tackle the problem of aeroelastic flutter with Fluent, separately from NASTRAN or oder FEM codes? I mean, could the following (decoupled) approach of aeroelastic flutter be correct?
1. Simulate the unsteady flow over a wing. 2. Save every time step my pressure loads over the wing as a NASTRAN, ANSYS or whatever 3. Import these files into my structural FEM analysis software and saying to it that these are my fluctuating loads over the wing. 4. Calculate structure response to these fluctuating inputs imported from FLUENT and study if there is resonance, etc.
The problem is that I want to make a flutter analysis over an object (to see if it will be flutter or not on this object), but I don't have neither computational resources nor experience in coupling Fluent with FEM structural software...
Thanks in advance for your comments on this.
Regards, Freeman
Re: Vortex shedding and aeroelastic flutter questi
Hello! sure it is possible. Have a look at the publications on www.aero.polimi.it/~cavagna Hope this helps you a little. Regards Luca
Could you shed me some light about this? Roughly write some lines in order to do FSI de-coupled, as my wing is quite small and it is expected not to exhibit arge deformations?
Thanks you in advance. Regards,
|All times are GMT -4. The time now is 23:58.


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JUser: :_load: Unable to load user with ID: 105710
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Aleph Number:
Researchers must register and agree to copyright and privacy laws before using this collection.
Collection is open for research.
Copyright for Official University records is held by Duke University; all other copyright is retained by the authors of items in these papers, or their descendants, as stipulated by United States copyright law.
[Identification of item], Sarah P. Duke Garden Reference Collection, Duke University Archives, David M. Rubenstein Rare Book & Manuscript Library, Duke University.
The Sarah P. Duke Gardens Reference Collection was compiled from a variety of sources by University Archives staff for reference and research.
Processed by Sherrie Bowser, June 2007
Encoded by Sherrie Bowser, June 2007
Updated by Molly Bragg, July 2011
Accessions were merged into one collection, described in this finding aid.
The Sarah P. Duke Gardens Reference Collection contains files of clippings, brochures, maps, history of the gardens, symposium and promotional packets, and other material concerning the Duke Gardens.


text:
The name or term Overkill refers to more than one character or object. For a list of other uses, see Overkill.
We need visual confirmation
This article is in need of images.
Overkill was Cobra's main technology and robotic energy weapons designer. Some of his most noted creations included the B.A.T.s and a massive biomechanical weapon named Overlord Vector.
Say, you look familiar...
This character doesn't have much of an established backstory. Unless contradicted by a canon source, you can assume their history mostly mirrors Over Kill's.
Animated continuity
Comics continuity
External links
Is this all there is?!!
This character article is a stub and is missing information. You can help Joepedia by expanding it.


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Eventually, after centuries of gold playing an important role in commerce, different cultures all around the world became familiar with the yellow metal. This gave gold an important quality of effective money, cognizability. This means that different people will all recognize the substance as money. Because gold is a very scarce commodity in the earth's crust, people saw it as valuable, but cognizability refers to different people generally agreeing upon this value. This also led gold to acquire another important quality of money, fungibility. A fungible asset is one that will be accepted as money in exchange for other products or services (with the expectation from the recipient that their money will later be accepted by someone else). For example, people may recognize that diamonds are valuable but will not be willing to accept them as money because they are so difficult to divide up.
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Mankind has used gold as a storage of wealth and a method of easily transporting wealth since the times of antiquity. Called "the money of kings," it has also long been associated with luxury and power. Throughout history, gold has been used as money for a number of reasons: it is scarce; malleable and dense, therefore highly portable; recognizable and lustrous; and timeless, both retaining its intrinsic value and never tarnishing.
Today, gold serves as a preservation of wealth, and an "insurance policy" against systemic economic risks. At Gainesville Coins, we have something to suit every gold buyer's tastes. For the investor looking for name recognition and maximum liquidity in their bullion, we carry legal tender gold coins such as the American Gold Buffalo, Canadian Gold Maple Leaf, and Chinese Gold Panda. For those looking to minimize premiums, Gainesville Coins offers a wide array of PAMP and Credit Suisse gold bars, as well as gold bars from the Royal Canadian Mint and Perth Mint.
Investors looking for a little personality in their gold should be pleased with our selection of Pre-1933 U.S. coins, both graded and ungraded. We also carry historic gold coins such as British Sovereigns, French "Roosters", and Mexican Gold Centenarios. Buyers looking for collectible bullion have several options at Gainesville Coins. We carry the Perth Mint Lunar coins, the Chinese Gold Panda, and many other proof and collectible gold coins.
Why Invest in Gold Bars?
Gold was first discovered as nuggets in stream beds. It wasn't long before ancient man figured out how to melt them together to make them easier to carry and store, giving birth to the gold bar. Bars are still the lowest premium option for buying gold, even when they are the decorative Lady Fortuna bars from PAMP Suisse. Bars come in many sizes for the retail investor, from the tiny 1 gram to the hefty 1 kilogram. Many bars come with a serial number stamped right on the bar, and are sealed together with an assay card that carries a matching serial number.
Poured Gold Bars vs. Pressed Gold Bars
Gold bars (and all bullion bars, for that matter) are made in two ways: poured, and pressed. Pouring was the original way to make bars. Molten gold is poured into molds, then allowed to cool. They are then stamped with the weight, purity, assay mark, and refiner. Pressed (or minted) bars are made from solid gold bar stock, cut at the precise point to produce uniform bars of an exact weight. The bars are then fed into a giant press, much like a coining press, where the weight, purity, assay mark and refiner are struck by dies onto the bar. Pressed bars are much faster to produce than poured bars. This makes pressing the preferred method of making smaller bars (those under 1 kilo), though poured bars can also be found.
A gold round (or medallion, as it is sometimes called) is basically just a round bar that has been minted with a more intricate design. These are not nearly as common as their silver counterparts.
Buying Gold Coins
For thousands of years, gold has been used in trade between different cultures, helping to spread the idea of commerce (and various kingdoms or empires). Archeologists can use discoveries of buried coins to determine how far the influence of ancient empires extended.
While the days of circulating gold coinage are regretfully over, you can still hold gold coins as a preservation of wealth. Gainesville Coins not only carries the latest in modern bullion coins from mints across the world, it also keeps a supply of formerly circulating gold coins, stretching back to the 19th century. Add the Liberty Head Eagles, Quarter Eagles, Half Eagles, or Saint-Gaudens Double Eagles to your collection for exposure to the classic Pre-1933 U.S. gold coins. The selection isn't limited to U.S. gold, either. Select among French 10- or 20- franc coins, British sovereigns from a number of different monarch's reigns, and even Swiss francs or Dutch gulden from the 1800s.
In addition, the past three decades have seen an explosion of government-issued gold bullion coins. Produced by government mints with official legal tender status, these coins are struck from .999 fine gold or better specifically for investors. The most well-known of these kinds of coins is the American Gold Eagle. The modern Gold Eagle (not to be confused with the $10 gold coin denomination that circulated before 1933) comes in a variety of sizes for different budgets investing tastes.
Due to their high level of quality, liquidity, and trust, these bullion coins generally carry higher premiums than more generic gold bullion products. The artistic designs of most gold bullion coins issued by national mints are also representative of the culture and symbols of the issuing country. A few other prominent examples are the Chinese Gold Panda, Canadian Gold Maple Leaf, Austrian Gold Philharmonic, and the Perth Mint's Australian Gold Kangaroo.


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Lexington County Choral Society
- 865 Corley Mill Road
- Lexington, SC 29072
- Phone: 803-359-8794
- Fax: 803-359-2965
- Visit Website
The Lexington County Choral Society (LCCS) began as most things do - simply as an idea in the minds of two individuals, Harold and Linda Scott McIntosh. The idea was to have a community choral group that would specialize on not just major choral works, but on the vast repertoire of choral anthems that exist.
Our first concerts, December 12,13,14 of 1996 were performed by a group of 72 singers. In the Spring of 1997, our group had grown to around 82. In the fall of 1997 our group grew to 92. Now we sing with over 100 members in this exciting organization.
It has become apparent that this idea was one whose time had come in South Carolina's fastest growing county.
- Price Range Maximum: $$ - $101-150