text:
We enjoyed our stay here, but I'm reviewing this hotel based upon it's status as a 5 star hotel. If this were a lesser ranked hotel it would get 5 stars from me. The room was nice, but quite small. It was also loud with the co-joined room, presumably because the interior door had about an inch of clearance from the floor. We could almost make out whole conversations from our neighbors. You had to pay for the internet daily, which I personally don't care for when I'm paying that much for a room. And the "business center" consisted of one old desktop hooked to a printer, for which there was a line waiting to use it.
The good: the staff was very friendly and helpful. The location was outstanding, right in union square. The breakfast was amazing. All in all, we enjoyed it, but there's still some room to grow to get 5 start status. For the right price we would stay here again, but not for full price.
- Official Description (provided by the hotel):
- Taj Campton Place is the quintessential landmark San Francisco Hotel on Union Square. It's located just steps away from the City's best shopping, dining and nightlife. Award-winning Campton Place Restaurant and Bar one of the City's most revered dining destinations. Executive Chef Srijith's cuisine with renowned Master Sommelier Richard Dean's wine cellar combined to create an unparalleled culinary extravaganza. Campton Place's superb location, elegant guestrooms, extraordinary service, outstanding amenities make it San Francisco's ideal home away from home. ... more less
- Reservation Options:
- TripAdvisor is proud to partner with Booking.com, Expedia, Travelocity, Orbitz, Hotels.com, Hotwire, Priceline, TripOnline SA, Cheap Tickets, Cancelon, getaroom.com and HotelQuickly so you can book your Taj Campton Place reservations with confidence. We help millions of travelers each month to find the perfect hotel for both vacation and business trips, always with the best discounts and special offers.
- Also Known As:
- Taj Campton Place Hotel San Francisco
- Hotel Campton Place


text:
Anzac Biscuits
READY IN: 30mins
Recipe by Susie T
An traditional Australian biscuit made in memory of our diggers during World War 1. ANZAC stands for Australian and New Zealand Army Corps.
Top Review by Sandra Hyde
As an Aussie, I have made ANZAC biscuits often. This recipe is a little different to the one my mother had, but it is very good. Fairly easy to make and the instructions are clear. Cook and enjoy like I did.
See Discussion:3 Reviews
Ingredients Nutrition
- 60 g butter
- 1⁄2 cup rolled oats
- 1⁄2 cup coconut
- 1⁄2 cup plain flour
- 1⁄2 cup caster sugar
- 1 tablespoon golden syrup
- 1 teaspoon bicarbonate of soda
- 1 tablespoon hot water
Directions See How It's Made
- Preheat oven to 160°C.
- Lightly grease two baking trays.
- Combine rolled oats, coconut, flour and sugar.
- Place butter and syrup in a saucepan and heat until butter is melted.
- Dissolve bicarbonate of soda in water and add tot he pan while it is still foaming.
- Pour this mixture over the dry ingredients and mix well.
- Place spoonfuls of the mixture onto the trays.
- Allow room between biscuits for spreading.
- Bake for 15-20 minutes.

subset: commoncrawl


text:
When I have children of my own, there is one piece of advice above all others that I shall press sternly upon them. More important than always listening to teacher, or learning the Green Cross Code, or not accepting sweets from strangers. And that piece of advice is this.
Don't speak. Ever. At least until you're 21, or better still 25, just to be on the safe side. But definitely not while you're a teenager. And especially not when there's a television camera in the room.
And if they don't understand why, I'll show them A Very English Education (Sunday, BBC Two). This was a programme catching up with the participants in The Public School, a BBC documentary made 33 years ago about teenage boarders at Radley. Boarders such as one Rupert Gather.
"I rather sort of fancy myself as the cultured intellectual," this benighted child informed the camera, in his best Martin Amis drawl. He was interested only in getting into Oxford, he went on airily, because "I couldn't face the thought of being stuck away in somewhere like Rotherham, you know."
You see, children? You see? Never speak. Not until you're an adult, and are old enough to know better than to tell people that you rather sort of fancy yourself as the cultured intellectual who couldn't face the thought of being stuck away in somewhere like Rotherham, you know. (There was actually a far worse example of teenage boys saying things they really shouldn't. It involved a teenage boy cheerfully boasting, again to camera, about the sort of thing he and his fellow teenage boys liked to get up to when they found themselves at a loose end. For the sake of your breakfast I won't quote him.)
In A Very English Education, these boys, now middle-aged, reflected blushingly on their teenage selves, and talked about life since. These days they all seemed fairly normal, which was a shame – they were much more entertaining to watch as teenagers. The old footage was priceless. A boy noisily campaigning for, of all things, the Workers' Revolutionary Party (while the other boys jeered and booed); a boy being scolded for driving to school in a car (and, even worse, bringing a girl with him). Also the speech about acquiring "the right habits for life", given by the quietly unnerving headmaster, his voice like the creep of soft shoes on thick carpet.
I hope, 30-odd years from now, Channel 4 does a follow-up programme about Educating Yorkshire. Partly because it would, like A Very English Education, make a fascinating televisual time capsule. And partly because it would give my children something with which to scare their own children into silence. It would be a valuable public service.
A somewhat graver documentary was Bedlam (Thursday, Channel 4). This was the first episode of a series about patients at South London and Maudsley psychiatric hospital, originally known as Bethlem or "Bedlam".
This week we met patients suffering from various forms of anxiety. One young man spent most of his day on the lavatory, obsessed with the (false) idea that he couldn't control his bowels. A woman was convinced that she kept physically harming people and leaving their bodies in bins. She'd never done anything of the sort. All the patients were perfectly coherent, pleasant and outwardly "normal" – they simply happened to believe things about themselves that were manifestly untrue, and these delusions were ruining their lives and relationships.
I want to say I felt nothing but sympathy. But it wouldn't quite be true. I did feel sympathy – the patients' struggles were heartbreaking. But I wonder whether any other viewers also found, somewhere in the recesses of their mind, a tiny, awful part of them that refused to understand, that wanted to shout in frustration, to grab these poor blameless people by the lapels and order them to pull themselves together and stop believing such nonsense.
Totally unfair, of course. But hard to block out. Where did it come from, this small, shaming voice? Some lingering atavistic hatred of weakness?
I suspect it had more to do with fear. Fear that one day we ourselves might become like these patients, that we too have the potential to suffer this kind of nightmare, that beneath the surface, delusion lurks inside us all. And so – as with a repressed homosexual who loudly denounces gay people – fear transmutes into callousness. It's pure denial. Or, if you like, pure delusion.


text:
I can't stress enough just how awesome cd.textfiles.com is for finding ancient stuff!
I'm not sure why I started on this quest but I was looking for some old finicky DOS extender, and started hunting for Go32, the first DOS extender used by DJGPP. And for the heck of it, I wanted to find the first version, which I pretty much had assumed was lost to the mists of time.
However the CD-ROM shareware collection called MegaROM-1 actually had a 'full' copy of the first version of DJGPP.
Installation is pretty straightforward, however you have to use pkunzip for all the various old 'methods' of storing data in zip files, I found infozip leaves things out..
Also DJGPP 1.00 uses a LOT of environment space.. which is more so a problem for people running real MS-DOS on real machines.. (there are some!)…
It runs in DOSBox, but there is no doubt some stack corruption as trying to run things like dos edit result in:
But at least we can run more than one copy, or use a native editor.
GO-32 from this era is *NOT* DPMI compliant, nor is it VCPI compliant. And its based on GCC 1.39, which was a popular level with things like 386 BSD, although it seems early Linux used GCC 1.40 ..
For those who want to play, without the pkzip fun, I've slapped it into a single 7zip file. It's not even a megabyte. But it was 1991, when 4MB of ram seemed like an incredible amount of memory!


text:
Pet Sitter in Fort Wayne
Hello my nane is autumn and im currently employed however i am looking for a job that better suites my expirience and personality :) i love my fur babies. No kids yet so i take my animals very seriously and i would love to help you with yours. Also my schedule is very flexible .
Pet Sitter Details
|Email Address
|Phone Number
|260-433-... Confirmed
Dog Walking
Pet Feeding
Pet Sitting
Pet Grooming
Overnight Care
Notes made here will only be seen by you. If you want to message the owner of this listing
More in Fort Wayne, Indiana
Looking for Pet Sitter jobs in Fort Wayne, IN?
Find available jobs in your city.
Featured Pet Care Providers near Fort Wayne, IN


text: Ummm? Eddie LeBarron's nickname was "The LITTLEST General". He EARNED that title as a Marine Corps 2ndLt, after being wounded twice on the front lines. He was later awarded the Bronze Star Medal and retired as a Maj. Roger Staubach's " battle experience in Viet Nam", consisted of a one-year tour of duty as a Supply Corps officer at the Chu Lai base/port. A secondary air base providing relief for Da Nang Air Base approximately 50 miles to the northwest.


text:
Couples Who Drink Together, Stay Together.Don't be scared to toss back a few, it might help your relationship.
The Best Signs That Someone Is Into You!How do you know if they are really into you?
Is This Uber Love At First Sight?
You're Most Likely To Get Dumped On This Day Of The Year!...and it's quickly approaching!
Iggy Azalea Rates The Likelihood of a Relationship With French Montana [VIDEO]You can tell when us girls like a guy, we have it written all over our faces and in this video, you can tell that Iggy is feelin French times 5!
Drake's Dad Says Drake and Rihanna Are Just Friends [VIDEO]The best part of this video is the girls Drake's Dad is hanging out with.
Don't Ever Cheat On Tyra Banks. That's What We Learn In Drake's New "Child's Play" Video [VIDEO]"Child's Play" isn't just a music video, it's a short film.
Rihanna Tells Drake She Loves Him In Instagram Post [PIC]The Drake and Rihanna love story continues....
Let's Talk About The New Bachelor.... Nick ViallHere are all my thoughts on the new Bachelor who is no stranger to the franchise.
Katy Perry Finally Spoke Out About Catfish EpisodeThis poor guy actually thought he was dating Katy Perry, he can now rest assured that he was not.
JoJo and Jordan Move Into Their New Dallas Home [PICS]Even if you aren't a fan of Jordan Rodgers, you can still appreciate him with his shirt off.
Two Engaged Couples From This Season's Bachelor In Paradise Revealed [PIC]If you can't wait the whole season to find out who gets engaged, you're in luck.


text:
26 October 2005
Bone marrow donors risk DNA identity mix-up
IT SOUNDS like an open-and-shut case: a clear DNA match is made between semen from a serious sexual assault and a blood sample from a known criminal. Yet in a recent case from Alaska, the criminal in question was in jail when the assault took place. And forensic scientists had already matched the crime sample to the DNA profile of another person who was their prime suspect. It was only after careful detective work that the mystery was solved: the jailed man had received bone marrow from the suspect many years earlier.
This week, at a meeting of the American Society of Human Genetics in Salt Lake City, Utah, Abirami Chidambaram of the Alaska State Scientific Crime Detection Laboratory in Anchorage described the case to highlight the danger of miscarriages of justice. Given the retribution that can be doled out to sex offenders by other jail inmates, the consequences could be severe. "If you implicate the wrong person, they can be killed in prison," says Chidambaram.
As forensic DNA databases grow and more people undergo bone marrow transplants, the risk of a miscarriage of justice increases
When Chidambaram discovered the perplexing match, she initially thought there had been a sample mix-up. But there was no mistake. What's more, the jailed man and suspect shared the same surname.
Because medical records are confidential, a detective had to make further enquiries among family and friends of the two men. That revealed that not only were the convict and suspect brothers, but the inmate had received a bone marrow transplant from his brother. As a result, his blood was populated with cells bearing


text:
liars! liars! pants (& skirts) on fire!
it is clear naman to the informed public that the celibate bishops and priests plus fundamentalist preachers like mike velarde who insist that contraception is a kind of abortion and therefore evil are LYING, no ifs or buts about it.
what's not clear is, where do they get the gumption to lie like this? what makes them so fearless, even so certain, that they speak a truth?
after some googling my theory is that they're taking their cue from the u.s. of a., no less, where matagal nang may population management at matagal nang legal ang abortion ngunit hindi pa rin sumusuko ang mga pro-life, lalo na ang bush administration, sa pagkontra sa mga pro-choice.
ang latest strategy ng bush administration is a proposal of the department of health and human services to re-define abortion to include all kinds of contraception and, guided by this, to allow anti-abortion health practitioners to refuse to make contraception available to women in need.
the proposed new definition of abortion:
any of the various procedures — including the prescription, dispensing and administration of any drug or the performance of any procedure or any other action — that results in the termination of the life of a human being in utero between conception and natural birth, whether before or after implantation."
of course imbiyerna ang mga pro-choice, unang una na si hillary clinton:
The Bush administration is up to its old tricks again, quietly putting ideology before science and women's health. The U.S. Department of Health and Human Services is poised to put in place new barriers to accessing common forms of contraception like birth control pills, emergency contraception and IUDs by labeling them 'abortion.' These proposed regulations set tobe released next week will allow healthcare providers to refuse to provide contraception to women who need it. We can't let them get away with this underhanded move to undermine women's health and that's why I am sounding the alarm."
wow, we sure could use a hillary clinton to take on the lying celibates and preachers in this overpopulated part of the world. compared to a giant like hillary, gma who loves the bishops and whose spiritual adviser is mike velarde is truly a midget of underhanded and unqualified proportions.
MORE: radicalchick's don't forget the woman, caffeine_spark's some cold, hard facts
6 Responses to liars! liars! pants (& skirts) on fire!
July 26, 2008 at 10:52 am
* Why is the Catholic Church in this country so conservative and backward- looking (like being 100% against population control)?
God answers:They take very literally the "Go forth and multiply" adage without realizing that your land space has not increased even an inch since the earth's creation.
July 27, 2008 at 2:54 am
You are absolutely right to This is absolutely crazy!
These religious freaks are completely wrong — where do they come from? Use of contraception is abortion? They are almost criminals! Bollocks!
Why can't Filipino women just ignore those bishops?
I mean, it's not as if these bishops will send them to jail or to hell if they use contraception(at least not straight away; according to Catholic dogma, there's confession that they can bank on in case women using contraceptions change their mind or maybe when they start menopausing they can confess by then, there's no worrying about getting pregnant anymore! Heheh).
But seriously, isn't there anybody in this govt that's not superstitious? If those religious freaks are giving a false message about contraception and abortion, isn't the sensible thing to do is to re-calibrate things and at the very least is for some educators, health workers, nurses or doctors to explain the difference between abortion and contraception from a medical point of view and let the women decide.
July 27, 2008 at 3:01 am
The religious freaks in Manila will probably burn me at the stake if they learn that I don't fail to tell my children (especially the oldest who's a boy) not to forget that in their physical relationships with the opposite sex, accidents can be prevented, that life threatening viruses can be avoided, etc by using condom.
I'm not encouraging my kids to have physical relationship with their partners (my kiddies are teenagers save for the oldest who is over 18) but it is my belief that you never know what kiddies do nowadays with their "friends" and I am a believer that forewarned is forearmed… It is the duty of the parents to talk to children about things that we would like to shy away from — if we truly love them.
July 27, 2008 at 12:39 pm
hi anna ;) indeed sex education pa rin ang sagot sa religious freaks. but no, no one in the mass media is bothering to just keep explaining the difference between contraception and abortion. i truly worry about the effect of such a campaign on the masses of uneducated uninformed pinoys.
July 29, 2008 at 11:50 pm
nakakatawa yung sinabi ni Ate Glo kanyang SONA…and I quote hehe "Nag-aalala ako para sa naka-aawang maybahay na pasan ang pananagutan para sa buong pamilya"
Kasi naman ipinagbabawal niya na bigyan ng pagkakataong mamili ang mga may-bahay kung paano nila paplanuhin ang kanilang pamilya ayon sa kanilang kakayahan. Dahil sa pangingialam ni Ate Glo at sa kagustuhan nya maging mabango sa simbahan, ayan madami tuloy siyang anak…at sya lahat ang nagaalaga. As if naman aalagaan ng simbahan yung mga batang hindi na kayang alagaan ng mga ina nila. Kaya ayun, may mababalitaan nalang tayong batang hinahagis sa labas ng taxi…finuflush sa toilet…at tinatapon sa basurahan.
Kakainis! hehe
October 4, 2011 at 5:30 pm
My brother suggested I might like this website. He was totally appropriate. This post actually manufactured my day. You can not imagine simply just how much time I had spent because of this info! Thanks!


text:
Let us know when your receive great advice so we can thank our lawyers and point others with similar questions in the right direction.Got it!
i was given a battery citation inl as vegas. i live over 2000 miles away. what will happen if i cant make my court date?
A warrant will be issued for your arrest; if you go back to NV and get a traffic stop you may be arrested on the warrant. Depending on how serious it is it may even show up on a traffic stop in your home state. It's better to hire a lawyer to take care of this for you. NOTE: some court clerks will tell you to send a letter of explanation; don't bother. The judge has a special trash can for letters like this.Ask a similar question
You need to have a lawyer take care of this citation for you.
I provided information on the city of Las Vegas. Your case may be in Clark County. You must have this taken care of and should talk to a lawyer.
Disclaimer: Information contained on these pages is intended for general information purposes only; it is not intended, nor should it be construed nor interpreted, as legal advice.
Check Status of Warrants
If you believe you may have a warrant, you may:
* Contact the Las Vegas Municipal Court for information and assistance at (702) 229-2067 or (800) 654-6856 if out of state.
* Go to any court counter location during business hours with valid State or Government issued picture identification:
o State Driver's License
o State-issued Identification Card
o Military Identification Card
o Military Dependent Identification Card
o Clark County-issued Work Card
o United States or foreign passport
* Contact an attorney licensed to practice law in Nevada to represent you.
You may be required to post bail. In most instances, you may avoid arrest by posting bail to satisfy your warrant.
Warrant Tip Line
If you know someone with active warrants out of the Las Vegas Municipal Court who currently resides in the Las Vegas metropolitan area, you can contact the Las Vegas Marshal's Office by e-mail or by calling (702) 229-2422. All tips will be kept strictly confidential.
NRS 199.335 Failure to appear after admission to bail or release without bail.
1. If a person:
(a) Is admitted to bail, whether provided by deposit or surety, or released without bail;
(b) Is not recommitted to custody; and
(c) Fails to appear at the time and place required by the order admitting him to bail or releasing him without bail, or any modification thereof,
íŠ the person is guilty of failing to appear and shall be punished pursuant to the provisions of this section, unless the person surrenders himself not later than 30 days after the date on which the person was required to appear.
2. If a person who fails to appear in violation of subsection 1 was admitted to bail or released without bail incident to prosecution for:
(a) One or more felonies, the person is guilty of a category D felony and shall be punished as provided in NRS 193.130.
(b) One or more gross misdemeanors but no felonies, the person is guilty of:
(1) A gross misdemeanor; or
(2) If the person left this State with the intent to avoid prosecution, a category D felony and shall be punished as provided in NRS 193.130.
(c) One or more misdemeanors but no felonies or gross misdemeanors, the person is guilty of:
(1) A misdemeanor; or
(2) If the person left this State with the intent to avoid prosecution, a category D felony and shall be punished as provided in NRS 193.130.
(Added to NRS by 1967, 1470; A 1979, 1423; 1995, 1178; 1999, 1848)
NRS 199.340 Criminal contempt. Every person who shall commit a contempt of court of any one of the following kinds shall be guilty of a misdemeanor:
1. Disorderly, contemptuous or insolent behavior committed during the sitting of the court, in its immediate view and presence, and directly tending to interrupt its proceedings or to impair the respect due to its authority;
2. Behavior of like character in the presence of a referee, while actually engaged in a trial or hearing pursuant to an order of court, or in the presence of a jury while actually sitting in the trial of a cause or upon an inquest or other proceeding authorized by law;
3. Breach of the peace, noise or other disturbance directly tending to interrupt the proceedings of a court, jury or referee;
4. Willful disobedience to the lawful process or mandate of a court;
5. Resistance, willfully offered, to its lawfuAsk a similar question
Post a free question on our public forum.Ask a Question
- or -
Search for lawyers by reviews and ratings.Find a Lawyer


text:
Flat Daddies was a Wikiality.com Featured Word on 04/16/07.
Flat Daddies[1][2] are cardboard cutouts (sometimes posters), from the waist up, of soldiers deployed in Iraq. The Army has graciously taken the initiative and has provided some of the families who have loved ones serving in Iraq with likenesses of that person to remind them that the soldier is not physically there, but overseas in a foreign land,
fighting in a civil war fighting for the Iraqi Freedom Opportunity.
Some people, mostly those against families (gays, liberals, commies, atheists, et al), have criticized the initiative for being "creepy" and "weird." What they don't seem to realize is that interacting with a life sized cardboard cutout of the person you love, who happens to be in the military and also happens to be stationed in Iraq, is a completely normal thing and isn't providing a false sense of security or misplaced affection.
Other Uses Edit
It should be noted that interacting with inanimate objects that bear a human likeness isn't a new practice. Christians have been doing this for over a millenia by going to church so that they could visit Jesus on his cross and many even have a miniature Jesus with them at all times that can be used as a God communicator to better facilitate the prayer process. If the Flat Daddies soldier series does well, the Catholic church may roll out a "Flat Sky Daddy" series to maintain a better connection with their constituents when they're out of church.


text: IRVINE, Calif., Feb. 27, 2014 (GLOBE NEWSWIRE) -- MRI Interventions, Inc. (OTCQB:MRIC) announced today that its novel ClearTrace ® system for MRI-guided, catheter-based cardiac procedures will be featured in a presentation at the 7 th Annual Western Atrial Fibrillation (AF) Symposium on Feb. 28-March 1 in Park City, Utah. The Western AF Symposium assembles a distinguished faculty of physicians and researchers from five continents to discuss the disorder, its relationship to heart failure, standards for patient care and technical advancements in the field. On Friday, Dr. Ravi Ranjan, cardiologist at the University of Utah, will give a talk entitled "The AF Ablation Lesion Detected Using MRI," highlighting the need for real-time assessment of lesions during minimally invasive catheter-based cardiac ablation and the techniques developed to enable intraprocedural visualization using MRI Interventions' ClearTrace system. On Saturday, a related presentation will be given by Dr. Nassir Marrouche, Associate Professor of Medicine and Director of the Electrophysiology Lab at the University of Utah, and the Executive Director of the Comprehensive Arrhythmia Research & Management Center (CARMA), titled "MRI for AF: Lessons from DECAAF." The DECAAF study highlights two main factors that determine the success of a minimally invasive ablation procedure: the stage of atrial fibrosis before ablation therapy, and the amount of residual fibrosis after the treatment. The study ultimately concluded that atrial fibrosis appraised by delayed enhancement MRI was associated with the probability of recurrent arrhythmia, exhibiting the usefulness of using MRI to assess AF in patients. Dr. Marrouche's presentation on the DECAAF study will demonstrate the importance of MRI in staging and assessing AF patients, and Dr. Ranjan's talk will highlight the benefits of an MRI-guided catheter-based cardiac procedure. Talks entitled "MRI Detected Fibrosis vs. Electrical Mapping" by Dr. Pierre Jais, Professor of Cardiology, Centre Hospitalier Universitaire de Bordeaux, and "The AF Ventricle in MRI" by Dr. Chris McGann, Director of Imaging for the Division of Cardiovascular Medicine at the University of Utah, will also emphasize the increasing role of MRI in treating atrial fibrillation.


text:
Allen E. Aaronson, MD, FAAP
Amy Cochran, MD, FAAP
Kelly Osborne, CPNP
Anke Blaine, CPNP
Nancy C. Goeden, MD, FAAP
Taren Miller, RN, MSN, CPNP
We are committed to providing you with the finest pediatric and adolescent care available.
Our pediatricians are certified by the American Board of Pediatrics and were trained at the top-ranked pediatric programs in the country. They have families of their own, are members of your community and have provided care to local children for over 25 years.


text:
Join and be entered in the monthly give-aways for free prints!
You'll receive a once-a-month notification of new pictures in the gallery, as well as artist events, exhibitions and appearances.
The Twins. The higher and lower mind joined by recognition of duality, social and enjoying the company of others, thought and communication.
Size: 10 x 15 inchesMedium: WatercolorOriginal: Sold
Detail closeups:


text:
Pixopedia 2014 v0.4.0 Portable (+ Plugins and Manual) | 79 Mb
Most people use image editors to retouch their photos or create simple designs for their documents, emails or web pages. Therefore, most image editors share a number of commonly used features such as red-eye removal and contrast or hue controls. This means that there's often not much to discover when it comes to using such software.
Users might find Pixopedia to be a bit different in this respect.
Easily configurable brushes
Other applications also feature configurable brushes. This one, however, stands out from the rest because of the variety of settings the user has access to.
There are a some of presets, including textured brushes available, but the number of controls and customization options leaves a lot of room for experimentation.
A multitude of effects and filters
The left panel of the main window features a large number of filter and effect categories, ranging from common ones such as blur or sharpen to more curious examples, such as Highpass, Dilate and Top Hat. These, like the brushes, can be thoroughly customized and users can apply them either through the above-mentioned brushes or to selected areas of the image in order to create various results.
Further customization using plugins and scripts
For those who want to delve deeper into image editing and automation using Pixopedia, the application supports both third-party plugins or LUA scripts and comes with small collection of examples to help users get started.
An image editor for those who like to experiment
Pixopedia is a surprisingly well featured image editor that supports a number of tools one would come to expect of such a piece of software, and some that seem to be a bit more exotic. However, while using it to experiment with its various filters, brushes, effects and their options and settings can be very entertaining, putting this application to more serious uses may be a bit daunting because of its cumbersome and sometimes unintuitive interface.
Every brush has it's own settings, color, texture, background tile and other parameters.
Tools, actions, brush parameters are created as sticky forms. Forms can be detached and moved freely. This is useful when working with extended desktop with two monitors.
New drawing engine implemented: every shape border is drawn with current brush. Interior drawing of closed shapes uses it's own parameters.
New undo buffer engine: single stroke undo/redo, multiple strokes undo/redo (ornaments). Every layer has it's own undo buffer.
New in version 2014 0.4.0 (October 22, 2015)
Lot of internal changes (new virtual drawing surface).
Ad hoc adaptive convolution now displays proper modal form.
Image warping action: selection bound added (where possible). There are three types of selection bound: source, destination and both.
Colors action: Statistical correction mode added. This mode adjusts image pixels according to statistical data taken from another image.
Spreader action: new spreading mode added - Neighbour shuffler, with 5 sub modes: Random neighbour, Neighbour group - best luminance, Neighbour group - worst luminance, Neighbour group - luminance range and Neighbour group average.
New brush added: CML brush. CML stands for coupled map lattice, a model for simulating non-linear dynamical systems. A bunch of parameters for controlling brush behavior. Very interesting and cool strokes can be drawn using this type of brush. To see how it works, use big brush tips (50-70).
Pixopedia 2014 plugins
All plugins listed in this secion can be used only with Pixopedia 2014 version 0.2.4 and up. After downloading plug-in, unpack it, select directory where Pixopedia 2014 is installed and copy desired ppi plug-in in pixplugins subdirectory. All Pixopedia 2014 plug-ins have extension ppi.
Image Infector v2.0 - various image effects using cellular automata concept
Dislocator v1.0 - various image effects using kernel remapping, local gradient warping and grid slicing algorithms
I recommends Buy premimum account for High speed+parallel downloads!


text:
SYRACUSE, N.Y. - New league, new level, same result.
Stephen Strasburg, the top pick in the 2009 draft who signed a record $15.1 million contract with the Nationals, allowed one hit in six innings for the Syracuse Chiefs in a Class AAA International League game vs. the Gwinnett (Ga.) Braves before a standing-room-only crowd Friday night at Alliance Bank Stadium.
The Chiefs won the game 7-0 before a crowd of 13,766, a record for pro baseball in Syracuse dating back to 1876.
"Awesome,'' Strasburg said. "It gives me something to tell my grand children.''
Strasburg, 21, who pitched at San Diego State last spring, retired the first 10 batters he faced before Gregor Blanco's single with one out in the fourth inning. Blanco's hit was a grounder to centerfield.
Strasburg finished with one walk and six strikeouts, throwing 65 pitches, 45 for strikes. He did well at the plate, too, with two RBI, one on a second-inning single and another on a fourth-inning sacrifice bunt.
Strasburg said that he's happy with his development and will leave it to the media to speculate on when he'll be promoted to the Nationals. He said he doesn't worry about the caliber of the batter, only the execution of his pitches.
"Good pitching should get good hitters out,'' he said.
The Nationals said that they want Strasburg to feel comfortable at the plate, work on fielding his position and get an idea of how batters will react to his pitching.
"But, the most important thing is for him to get comfortable with the routine of pitching every fifth day,'' Nationals general manager Mike Rizzo said. "We want him to feel comfortable with pitching, then throwing a bullpen, playing long-toss and pitching again.''
By Mel Antonen
Daily Pitch is a baseball fan's destination for breaking news, emerging trends and enlightening banter. With a veteran group of reporters positioned in three time zones, we provide a balanced, comprehensive glimpse at our national pastime, with a nod to both the passion and complexities that make the sport irresistible to many. More about our reporters


text:
Chinese officials flee to the West with huge govt funds
Thousands of Chinese officials have fled overseas with a staggering USD 50 billion in their pockets, stolen from the exchequer.
Beijing: Hit already by mushrooming corruption and rising alcoholism among its bureaucrats, China has now been stung by revelation that thousands of officials have fled overseas with a staggering USD 50 billion in their pockets, stolen from the exchequer.
The funds were siphoned off from the government expenditure as the country entered an economic boom over the past three decades.
Officials were found to have used services of criminal gangs in other countries to buy fancy real estates and keep number of mistresses in their new havens after bolting from China by faking identification, the China Daily reported on Monday.
The paper quoting officials of the country`s Supreme People`s Procuratorate said developed nations like US and Australia had become "new heaven for those in hiding".
As many as 4,000 officials were found to have disappeared overseas and an alarmed government has formed a multi-agency task force to stem the flow of corrupt officials stealing and escaping to foreign nations.
Overseas trips have been put under close scrutiny since Yang Xianghong, the former party chief of a district in China`s eastern Zhejiang province went on an official visit to France in 2008 and refused to return home.
His wife was arrested by police on suspicion of trying launder USD 2.9 million.
The new joint panel consist of officials from public security, justice and foreign affairs departments. The new official efforts come, as China has recently sought to negotiate extradition treaties with western countries to bring back and punish officials.


text:
WKVI's Ed Hasnerl has announced the 2012 tour of Washington, D.C. and Gettysburg Battlefield, scheduled for June 14th through the 18th.
Stops on the five day motor coach tour, in addition to Gettysburg, include the U.S. Capitol, George Washington's Mount Vernon Plantation home, and the George Washington Memorial in Alexandria, Virginia for a special musical program.
Arrangements have been made to attend Sunday morning worship services at the Washington National Cathedral. A visit to a foreign country's embassy is planned as is a stop at the Tomb of the Unknowns at Arlington National Cemetery.
Of course, the group will see the Lincoln Memorial, the Iwo Jima Memorial, Jefferson Memorial, FDR Memorial, World War II Memorial, and many more. You will also see the original Declaration of Independence and the U.S. Constitution at the Archives of the United States.
Full details are available when you call WKVI at (574) 772-6241 and ask for the information to be mailed to you.
We'll have much more of the exciting details of this trip in later broadcasts.


text:
SPM leavers who scored at least 9A+ to receive financial assistanceMarch 25, 2013
As a reward for SPM leavers who scored at least 9A+ and above, the Ministry of Education will offer financial assistance to these students, regardless of race, ethnicity and background. The financial aid covers tuition fees and living allowance. To apply for the aid, students need to register http://apps.moe.gov.my/bursaryspm/


text:
Explore related topics
A breathy groan.moan.whimper escaped you then your eyes started welling with unshed tears. Satin Grey Lamborghini Aventador with Azure Blue and Carbon Fiber trims
I wanna get a car. I'll which Achieve when I'm 16 and I can drive I'll do good last the rest and learn to be safe.
Lamborghini Reventon! Seriously one of my favorite cars of all time Sexy Sport Cars
#Lamborghini Aventador
Blue Lamborghini- #LadyLuxuryDesigns
worldfam0us: auerr: Matte Galaxy AventadorYou know you want it. bringing them back lol
Liberty Walk inspired carbon Lamborghini Huracan by @robevansdesign #WidebodyLamborghiniHuracan
Tyga - Lamborghini Aventador Covered in rose gold Avery Dennison Supreme Wrapping Film by West Coast Customs
Program your mind to make multiple millions and billions of dollars! This is super real... This is Neuro science! Click the picture and Sign up for my Free Ecourse.
Lamborghini logo More


text:
What is JotForm?
JotForm is a free online form builder which helps you create online forms without writing a single line of code. No sign-up required.
At JotForm, we want to make sure that you're getting the online form builder help that you need. Our friendly customer support team is available 24/7.
We believe that if one user has a question, there could be more users who may have the same question. This is why many of our support forum threads are public and available to be searched and viewed. If you'd like help immediately, feel free to search for a similar question, or submit your question or concern.
Some people are having issues with the Paypal link from our online formAsked by unitedinharmony on March 29, 2016 at 07:53 PM
All of people are getting error messages like: "my transaction could not be complete through PayPal" or ""your last action cannot be completed at this time" have you seen these error messages before? Is this something in connection with your site or is this an issue with paypal? could the issue be that the card is showing potential fraud and declining the transaction? It started off happening to about 1 or 2 people, now we are at close to 15 people having this issue.
Thank you.
JotForm Support
The issue with "your last action cannot be completed at this time" seems to be from paypal. I found a related thread in the Paypal forum about the issue here (Sorry — your last action could not be completed) and the suggestion there is to:
1. Logout of Paypal
2. Clear your browser cache and cookies
3. Close your browser
4. Reboot your computer
You can also try clearing the Form Cache by following this guide: How to Clear Your Form Cache?.
Alternatively, perhaps you can try re-integrating the paypal payment module to your form to see if that fixes the issue. However, if the issue persists, I would suggest you contact Paypal support.
Do let us know if you need further assistance.
When I went to delete the paypal link from my form it stated that all associated data would also be deleted, that made me a bit nervous, what does that mean exactly.
Lindsay Schwartz, Associate Director
United in Harmony
JotForm Support
That means that the data that was previously submitted in the Paypal field will be lost. We do not recommend doing that unless you have a backup of the form data. You may consider downloading the form submissions first before deleting the field. Otherwise, you can clone the original form and do the changes into the cloned version. If the issue will be fixed in the cloned version, you can used it.


text:
Revealing metabolite biomarkers for acupuncture treatment by linear programming based feature selection
Selected articles from The 5th IEEE International Conference on Systems Biology (ISB 2011)
The 5th IEEE International Conference on Computational Systems Biology (ISB 2011)
Acupuncture has been practiced in China for thousands of years as part of the Traditional Chinese Medicine (TCM) and has gradually accepted in western countries as an alternative or complementary treatment. However, the underlying mechanism of acupuncture, especially whether there exists any difference between varies acupoints, remains largely unknown, which hinders its widespread use.
In this study, we develop a novel Linear Programming based Feature Selection method (LPFS) to understand the mechanism of acupuncture effect, at molecular level, by revealing the metabolite biomarkers for acupuncture treatment. Specifically, we generate and investigate the high-throughput metabolic profiles of acupuncture treatment at several acupoints in human. To select the subsets of metabolites that best characterize the acupuncture effect for each meridian point, an optimization model is proposed to identify biomarkers from high-dimensional metabolic data from case and control samples. Importantly, we use nearest centroid as the prototype to simultaneously minimize the number of selected features and the leave-one-out cross validation error of classifier. We compared the performance of LPFS to several state-of-the-art methods, such as SVM recursive feature elimination (SVM-RFE) and sparse multinomial logistic regression approach (SMLR). We find that our LPFS method tends to reveal a small set of metabolites with small standard deviation and large shifts, which exactly serves our requirement for good biomarker. Biologically, several metabolite biomarkers for acupuncture treatment are revealed and serve as the candidates for further mechanism investigation. Also biomakers derived from five meridian points, Zusanli (ST36), Liangmen (ST21), Juliao (ST3), Yanglingquan (GB34), and Weizhong (BL40), are compared for their similarity and difference, which provide evidence for the specificity of acupoints.
Our result demonstrates that metabolic profiling might be a promising method to investigate the molecular mechanism of acupuncture. Comparing with other existing methods, LPFS shows better performance to select a small set of key molecules. In addition, LPFS is a general methodology and can be applied to other high-dimensional data analysis, for example cancer genomics.
Acupuncture, an important therapeutic method in Traditional Chinese Medicine (TCM), has been used to treat various diseases for thousand years in China. Recently it has been gradually accepted in western countries as an alternative or complementary treatment. However, how the acupuncture works remains an open question though acupuncture exists as one of the oldest continuous systems of medicine dating back 4,000 years. Extensive studies have been conducted on the mechanism of acupuncture to explain the effects of acupuncture on various systems and symptoms
In this paper, we use systems biology method to study the acupuncture treatment effect by identifying a subset of important molecules from high-throughput metabolic data. Specifically, we separate the acupuncture from moxibustion and only study the effect of acupuncture on normal people by investigating the difference between acupuncture at particular acupoint and without acupuncture. Towards this aim, we utilize 1H nuclear magnetic resonance (1H NMR) to investigate the effects of acupuncture at several meridian points on plasma metabolites. Then metabolite profiles (vectors) are generated from a collection of case samples(with acupuncture at meridian point) and control samples (without acupuncture). These high-dimensional profile data is very similar to SNP (sequence data), gene expression (transcriptome), mass spectrum (proteome), and small molecules (metabolome) data in different levels. Then the straightforward task is to identify differentially expressed molecules and further classify and predict the diagonostic category of a sample, based on its metabolite profile
Generally speaking, there are two difficulties in analyzing these high-dimensional profile data. First, a large number of features (metabolites in our case) are available to predict classes for a relatively small number of samples. The presence of a significant number of irrelevant features that are unrelated to the case status makes such analysis prone to the curse of dimensionality. Second, predictive accuracy is not the only goal and further biological validation and mechanism understanding call for explanatory power other than black box predictive results. Thus it is especially important to know which molecules largely contribute towards the classification. Ideally we can improve the generalization performance of classifier by identifying only the molecules that are significantly contribute to the classifier. This effect is attributable to the overcoming of the curse of dimensionality. For example, if it is possible to identify a small set of metabolites that is indeed capable of providing complete discriminatory information, inexpensive diagnostic assays for only a few metabolites might be developed and be widely deployed in clinical settings. Knowledge of a small set of diagnostically relevant metabolites may provide important insights into the mechanisms responsible for acupuncture treatment itself. Those molecules are usually termed as biomarkers. The procedure to reveal them is referred as feature selection, biomarker identification, or feature ranking.
Feature selection is known to be NP-hard
Existing feature selection strategies can be roughly categorized into three types
In this paper, we proposed a novel linear programming (LP) model to address this important problem. Feature selection problem is cast into an optimization problem with two objectives, one is to minimize the number of chosen features and the other is to maximize the predictive accuracy based on the centroid classification framework. In other words, our feature selection method simultaneously improves classification accuracy and selects features. Comparing with several state-of-the-art feature selection methods, our Linear Programming based Feature Selection (LPFS) method can select a small set of features by applying strong regularization while keeping high accuracy. We then apply our method to analyze the metabolite profile data generated for acupuncture treatment. We identify important molecules (biomarkers) related to the acupuncture treatment for several meridian points. Further characterization of the biomarkers and the common and difference among several meridian points provide biological insights for acupuncture mechanisms at molecular level. Preliminary results in this paper were presented in our conference paper
Analytic workflow
In this paper, the acupuncture treatment effect is investigated in the framework of systems biology. The basic analytic workflow is shown in Figure
Figure 1
Our analytic workflow to identify biomarkers for acupuncture treatment effect
Our analytic workflow to identify biomarkers for acupuncture treatment effect. Metabolite profiles are originally generated by 1H NMR from control samples and the samples with acupuncture treatment. Then we develop a linear programming based feature selection method to compare the two groups of metabolite profiles. Finally a small set of metabolites are selected as biomarkers for acupuncture effect.
Overview of the linear programming based feature selection
To investigate the high-dimensional data for acupuncture treatment effect, we develop a novel method, LPFS, to select a small set of metabolites to characterize acupuncture treatment effect. The schematic illustration of LPFS is shown in Figure
Figure 2
The schematic illustration of LPFS
The schematic illustration of LPFS. Under the nearest centroid framework, LPFS requires to minimize the classification error and the number of selected features, which leads to a multi-objective programming. To ensure the computational efficiency, a linear programming is solved to identify biomarkers.
Centroid classification prototype
A fast and simple algorithm for classification is the centroid method
with ║
Multi-objective optimization model
Suppose we have two groups in the training dataset, the case group and the control group as the gold-standard data to classify new samples. We denote them set
Let the feature number be
Suppose the test dataset is
Similarly given a control sample
With the above constraints for variable
Thus the feature selection problem is formulated as an integer linear programming problem in Equation (10).
When we consider the noise in the measured data, not all the test samples can be classified exactly. We introduce the tolerable error
Given a case sample
Similarly given a control sample
Thus the objective function composes two parts, i. e., we want to choose as few as features
The first term of objective function in Equation (13) is to minimize the number of chosen features, and the second one is to minimize the total classification error.
Mixed integer linear programming
The optimal solutions of the two-objective optimization problem consist of a Pareto set, which can be solved by transforming the two objectives of (13) into a single objective. One typical technique is the
(14) is a mixed integer programming (ILP). The objective function in (14) is
By solving the proposed mixed integer linear programming model (14), we can get solutions for the feature selection variables
Leave-one-out cross validation
The above model (14) is based on the general idea of cross validation, thus it depends on the choice of
Resubstitution error rate indicates only how good are our biomarkers on the training data. However, this model has "information leak" and will underestimate the classification error. In our implement, we choose the model for leave-one-out cross validation in Equation (16).
We adopt leave-one-out experiment since this particular form of cross validation is an unbiased estimator of the generalization performance of classifier. It makes the best use of the available data and involves no random subsampling. Every time we pick out one sample (
Linear programming approximation
In general, mixed integer linear programming is difficult to solve. To ensure the computational efficiency, mixed ILP in Equation (16) can be relaxed to the corresponding linear programming (LP). Linear programming is the simplest type of mathematical programming and has been widely used in systems biology study
After relaxing to continuous value, the value of the optimal solution of
Metabonomics profiling by 1H NMR spectra
Venous blood (3ml) was collected into a heparin sodium tube and the plasma was collected by centrifugation at 1000× g at 4°C for 10 minutes. An aliquot of 300
All plasma 1H NMR spectra were manually phased and baseline corrected using VNMR 6.1C software (Varian, Inc.). For CPMG spectra, each spectrum over the range of 0.4 to 4.4 was data-reduced into integrated regions of equal width (0.01 ppm). For BPP-LED data, each spectrum over the range of 0.1 to 6.0 was segmented into regions of equal width (0.01 ppm). The regions containing the resonance from residual water (4.6-5.1) were excluded. The integral values of each spectrum was normalized to constant sum of all integrals in a spectrum in order to reduce any significant concentration differences between samples
Metabonomics data generation
To investigate the acupuncture treatment effects, we originally obtained metabonomics data of plasma metabolites in healthy males at five meridian points using Proton NMR. Proton NMR (also named as Hydrogen-1 NMR, or 1H NMR) applies nuclear magnetic resonance in NMR spectroscopy with respect to hydrogen-1 nuclei within the molecules of a substance, in order to determine the structure of the molecules
As a result, most organic compounds are characterized by chemical shift values, which are usually expressed in parts per million (ppm) by frequency and are in the range +14 to -4 ppm. Chemical shift values are not precise, but typically they are regarded mainly as orientational. The exact value of chemical shift depends on molecular structure and the solvent in which the spectrum is being recorded. These chemical shift values can be mapped to eight metabolic subsets (amino acids, carbohydrates, energy, glycans, lipids, nucleotides, secondary metabolites/xenobiotics, vitamins, and cofactors). In our experiment, 400 chemical shift values are measured for their concentration in plasma, and mathematically every sample is represented by a vector in 400 dimensional space.
Fifty healthy young males were randomly allocated to Zusanli (ST36), Liangmen (ST21), Juliao (ST3), Yanglingquan (GB34), and Weizhong (BL40) groups (The locations of the meridian points are shown in Figure
Figure 3
Overall design of the biomarker identification experiments
Overall design of the biomarker identification experiments. a) Metabolite profiles are originally generated by 1H NMR from five acupuncture points (Zusanli (ST36), Liangmen (ST21), Juliao (ST3), Yanglingquan (GB34), and Weizhong (BL40)). b) The metabolite profiles are grouped into 7 sets and the biomarker identification problem is designed as 7 binary classification experiments.
Classification experiments design
With the data, we design experiments to identify biomarkers for the acupuncture treatment of each meridian point. The overall design of biomarker identification experiments is shown in Figure
Global characterization of the data
We first perform hierarchical clustering on the 80 metabolic profiles. The results are shown in Figure
Figure 4
Global characterization of the metabolite profiles
Global characterization of the metabolite profiles. a) Hierarchical clustering of the metabolic profiles of the 80 samples. b) Centroids for the seven datasets. The horizontal units are expression values for the metabolites. The metabolites are sorted by their chemical shift values.
Furthermore, we calculate the centroids for the seven groups of samples in Figure
The above results together demonstrate that global pattern in metabolic profiles cannot discriminate the Zusanli, Yanglingquan, Liangmen, Juliao, Weizhong, Pre1, Pre2, and Control I groups. Thus it is necessary to find the local pattern in the profile data. Our strategy is to find a subset of metabolites as biomarkers to achieve clear discrimination.
Comparison with other approaches
Before we conduct the acupuncture biomarker identifications, we benchmark our LPFS method by comparing with several existing state-of-the-art methods. There are many existing feature selection methods and they can be roughly categorized into three types, filter, wrapper, and embedded methods. To make the comparison simple and comprehensive, we pick out some representative methods in each type to compare in the same dataset.
Filter methods select features as a preprocessing step and feature selection part is independent of a machine learning algorithm (classifier). This is computationally efficient. Fold change and t-test are the simplest and popular methods to identify biomarker. They are usually the representative methods for filter methods.
The standard definition of the fold-change
On the other hand, wrapper method ranks features based on their effects on classification accuracy. It takes dependencies of the feature subset on the learning algorithm into account and is computationally more demanding. Support Vector Machine-Recursive Feature Elimination (SVM-RFE) is one of the most successful wrapper method based algorithm in the feature selection
Since our LPFS method is an embedded method and simultaneously optimize classification accuracy and the number of selected features, we specifically choose to compare with an existing method with similar strategy, called sparse multinomial logistic regression approach (SMLR). It was developed to jointly and simultaneously identify the optimal nonlinear classifier, and select the optimal set of features via the optimization of a single posterior objective function (see
Without loss of generality, we take Exp1 in Figure
Firstly, we compare different methods in Figure
Figure 5
Methods comparison via volcano like plots
Methods comparison via volcano like plots. Comparison of our LPFS method with existing methods regarding to the identified biomarkers. All the 400 metabolites are plotted into a two dimensional plane. The selected biomarkers are highlighted in red. The x-axis denotes the difference of means and the y-axis denotes the standard derivation. Good biomakers should locate either in the left bottom corner or in the right bottom corner. a) volcano like plot of t-test method. The top 10 features are in red. b) volcano like plot of fold change method. The top 10 features are in red. c) volcano like plot of SMLR method. d) volcano like plot of SVM-RFE method. e) volcano like plot of our LPFS method.
The t-test based method identifies 172 metabolites if we choose a cutoff 1.73 (corresponding p-value 0.05). A strict threshold will still select 84 metabolites with cutoff 2.84 (corresponding p-value 0.005). We list the top 10 in Table
Table 1
The top ten identified biomarkers by different methods on the ST36 meridian point.
Student t-test
Fold change
Our LPFS method
LPFS score
Metabolite name
The fold change based method identifies 159 metabolites if we choose a commonly used cutoff 2
Table 2
Identified biomarkers from different meridian points by our LPFS method.
Zusanli ST36
Liangmen ST21
Juliao ST3
Yanglingquan GB34
Weizhong BL40
While SMLR selects 37 features to achieve the 100% leave-one-out predictive accuracy. These 37 metabolites are plotted in Figure
SVM-RFE selects 15 metabolites in total to achieve the 100% leave-one-out predictive accuracy. These metabolites are illustrated in Figure
Our LPFS method finally selects 4 features as the biomarkers to discriminate ST36 and Pre1. By using only 4 features we can achieve 100% leave-one-out predictive accuracy. To show these four important biomarkers are not dependent on the nearest centroid classifier, we use SVM to do five-fold cross validation, the predictive accuracy is still 100%. This demonstrates that we can select a small set of important features really matters by applying strong regularization. The selected 4 metabolites are listed in Table
Secondly, we compare the results of these five methods in a venn diagram in Figure
Figure 6
Venn diagram for the results obtained by different methods
Venn diagram for the results obtained by different methods. a) Comparing t-test, SMLR, SVM-RFE, and LPFS methods by checking the overlaps of their selected biomarkers. b) Comparing fold change, SMLR, SVM-RFE, and LPFS methods.
In addition to the overall venn diagram, the top ten biomarkers obtained by the t-test, fold change, SVM-RFE methods are summarized in Table
Biological insights for the identified biomarkers
We then applied the proposed LPFS method to identify the biomarkers from the designed seven experiments. As a result, we identified 4, 7, 2, 3, and 8 biomarkers for the acupuncture treatment effects of ST36, ST21, ST3, GB34, and BL40 respectively. These selected biomarkers can achieve 100%,100%,100%,100%, and 95% leave-one-out cross validation accuracy. The results are summarized in Table
From Table
To reveal the similarity and difference of the identified biomarkers regarding to meridian points, we calculate the overlaps of these biomarkers and present them in Figure
Figure 7
Venn diagram for identified biomarkers from different acupuncture points
Venn diagram for identified biomarkers from different acupuncture points. The similarity and difference of those identified biomarkers from Zusanli, Liangmen, Yanglingquan, and Weizhong are shown in a venn diagram. The overlapped biomarkers are indicated by their ppm and known annotation.
Our results show that metabolite with chemical shift value 3.55 is clearly a common biomarker for ST36, ST21, ST3, and GB34. In Figure
Figure 8
Highlight the selected biomaker in 2D plot
Highlight the selected biomaker in 2D plot. Metabolic sample is visualized as a two dimensional image. Each grid denotes a group of metabolites with similar profiles. Red color means the highly expressed metabolite group and blue color means the lowly expressed metabolite group. In particular, metabolite with chemical shift value 3.55 is highlighted in white color and indicated by the star.
Importantly, our LPFS method reveals the metabolite with ppm 1.33 as a biomarker for meridian points ST36 and ST21. This molecule is annotated as lactate. Lactate has been extensively studied over years for many important functions. For example, the lactate has always been regarded as the central nervous system metabolic waste and a sign of hypoxia
Discussions and conclusions
Biomaker identification or feature selection considers the problem of constructing a prediction rule from only a feature-subset and accurately classifying the context of diagnosis and treatment observations (e.g. with vs. without acupuncture treatment). Such problems have become increasing important and quite general in genomics (identifying differentially expressed genes in microarray data), proteomics (finding promising protein marker from the mass spectrometry data), metabolics (selecting metabolite markers from NMR, GC-MS data), and other areas of computational biology. Due to the number of features is much larger than the number of observations, simple, highly regularized approaches are in pressing need. Here, we proposed a novel linear programming based feature selection (LPFS) model to address this important problem. The feature selection problem is cast into an optimization problem with two objectives, one is to minimize the number of chosen features and the other is to maximize the predictive accuracy. Mathematically the feature selection problem is formulated as a mixed integer linear programming problem. Then the model is further relaxed to linear programming to ensure the efficient identification of a feature-subset. We can solve the in-essence combinatorial optimization problem in a computational reasonable way. In summary, our LPFS method can select feature and learn the classifier in a joint way and we can select a small set of features by applying strong regularization. Our methodology is general and can be easily applied to other scenarios
We extensively compared our LPFS method with existing methods in the real datasets on acupuncture treatment at different acupoints. We find that, 1). Our method can select the fewest features while achieve accurate predictions. 2). Our method is free of arbitrary threshold choice. 3). Close check of the selected feature shows that our method can identify those biological meaningful features. 4). In addition, the cross-validation results show that our method can achieve relatively high accuracy in prediction.
Prior information allows further improvement of our method. Currently the identified biomarkers are independent to each other. We can move further step to interpretation by considering a group of biologically meaningful biomarkers. For example, we can incorporate the network information (interactions among features) into the feature selection procedure. As a result, a pathway or modules in the network will be finally selected instead of single molecule as the biomarker, so called network biomarker. We note that prior information can be easily incorporated into our optimization model either by adding some constraints or penalizing in the objective function.
In this paper, the biomarker identification for each acupuncture point is treated as a single binary classification task. We then compare the revealed biomarkers for their similarity and difference across different acupuncture points. We note that a multi-classifier can be developed to systematically integrate all the profiles from different points together. This topic is in progress as our further direction.
Finally, the metabolic profile is known for its high variance. We note that the main source of variance is from NMR technology instead of acupuncture effect
Competing interests
The authors declare that they have no competing interests.
Authors' contributions
YW proposed the computational method. QFW, XZY, SGY, and FRL designed the experimental study and generated the data. YW, CC, LYW, and XSZ implemented the method, performed the experiments and analyzed the data. YW and QFW wrote the manuscript. All authors revised the manuscript and approved the final version.
The authors would like to thank Prof. Luonan Chen, Dr. Ruisheng Wang, and ZHANGroup members for insightful discussions. YW, LYW, and XSZ are supported by NSFC grant 61171007, 11131009, 60970091, and CAS grant kjcx-yw-s7. QFW and FRL are supported by NSFC grant 30901933 and National Basic Research Program of China (no.2012CB518500). YW is also supported by SRF for ROCS, SEM and the Shanghai Key Laboratory of Intelligent Information Processing (No. IIPL-2010- 008).
This article has been published as part of
Mechanical signaling through connective tissue: a mechanism for the therapeutic effect of acupuncture
The mechanism of acupuncture analgesia: a review
The mechanism of acupuncture and clinical applications
Inferring gene regulatory networks from multiple microarray datasets
The elements of statistical learning: data mining, inference and prediction
On the approximability of minimizing nonzero variables or unsatisfied relations in linear systems
An introduction to variable and feature selection
Identifying biomarkers for acupuncture treatment via an optimization model
Lower dimensional representation of text data based on centroids and least squares
Proteomic pattern recognition
Recursive SVM feature selection and sample classification for mass-spectrometry and microarray data
A Linear Programming Framework for Inferring Gene Regulatory Networks by Integrating Heterogeneous Data
Optimization meets systems biology
An improved diffusion-ordered spectroscopy experiment incorporating bipolar-gradient pulses
A metabonomic investigation of hepatotoxicity using diffusion-edited 1H NMR spectroscopy of blood serum
Development of a model for classification of toxin-induced lesions using 1H NMR spectroscopy of urine combined with pattern recognition
NMR and pattern recognition studies on the time-related metabolic effects of
1H NMR-based metabo-nomic study on the metabolic changes in the plasma of patients with functional dyspepsia and the effect of acupuncture
Metabonomics and pattern recognition study on the specificity of foot-yangming Meridian points
A comparison of fold-change and the t-statistic for microarray data analysis
Gene selection for cancer classification using support vector machines
Multiple SVM-RFE for gene selection in cancer classification with expression data
Joint classifier and feature optimization for comprehensive cancer diagnosis using gene expression data
Sparse multinomial logistic regression: Fast algorithms and generalization bounds
Finding Diagnostic Biomarkers in Proteomic Spectra
A comparison of fold-change and the t-statistic for microarray data analysis
Statistical tests for differential expression in cDNA microarray experiments
Gene Expression Dynamics Inspector (GEDI): for integrative analysis of expression profiles
Differential effects of glucose and lactate on glucosensing neurons in the ventromedial hypothalamic nucleus
Lactate is a critical "sensed" variable in caudal hindbrain monitoring of CNS metabolic stasis
A metabolic switch in brain: glucose and lactate metabolism modulation by ascorbic acid
The in vivo neuron-to-astrocyte lactate shuttle in human brain: evidence from modeling of measured lactate levels during visual stimulation
Glucose and lactate metabolism during brain activation
Trends in biomarker research for cancer detection
NMR-based metabonomic approaches for evaluating physiological influences on biofluid composition
Improved analysis of multivariate data by variable stability scaling: application to NMR-based metabolic profiling
Application of orthogonal signal correction to minimise the effects of physical and biological variation in high resolution 1H NMR spectra of biofluids
Physiological variation in metabolic phenotyping and functional genomic studies: use of orthogonal signal correction and PLS-DA


text:
Mrs. Thirsty
Mrs. Thirsty is a boss. She is married to Thirsty the Midget. Jaynis and Taylor Kobb are her sons from her first marriage. She is a tallish middle age woman who is pretty despite premature ageing from life on Pandora.
Family Values: Mind the Vespas
Bounty Board: "Thirsty has spoken highly about your kind work you did for him. Regular Good Samaritan stuff. I remember him and me sitting and fishing for hours talking about all sorts of things. He makes me laugh. Anyway. I can't get my boys' ECHOs. Would you do me a Good Samaritan thing and remove the vespas by the post box on the highway. They're always in the way. "
Vespas: 0/20
Go to the post box. Kill the vespas that are next to the post box. [Vespas (or, Vespidae) is a family of wasps. However, these wasps are like tarantula wasps in that they burrow underground.]
Turn In: Bounty Board
Family Values: One Big Happy
Bounty Board: "Thirsty and my boys are suppose to be here for supper. If you could get me some rakks I would have dinner done. Get the ones that explode when they hit you 'cuz then they're already roasted. 10 will do. They like Crystal Lake. You can leave them at the gate."
Roasts: 0/10
A large Flock of Kamikaze rakks are at Crystal Lake as well as a few Psycho Midgets and numerous Badass Psychos. Collect ten roasts.
Turn In: Pleasantville Front Gate [Pleasantville is a trailer park surround by fences.]
Family Values: Last Trailer on the Left
Bounty Board: "Hi Honey. Oh, Sorry. I call everyone Honey. Thirsty and me had a lovely dinner. Did I tell you that him and me are married. The boys couldn't make it. He told me some disturbing news and I was hoping you could come and see me. He said that you could explain things."
Mrs. Thirsty met: 0/1
Go to the trailer park. Find Mrs. Thirsty's trailer. Open front door; it closes after entering. Meet Mrs. Thirsty. The only distinguishable items in the one-room trailer are two framed pictures of Jaynis and Taylor Kobb.
"I use to be Mrs. Kobb."
Mrs. Thirsty killed: 0/1
Fight Mrs. Thirsty. See uses a machine gun or a rocket launcher. [She taught her boys.] A player can open the front door but must wait for it to – Slowly - open. [It's like the sword fight between Beatrix Kiddo and Elle Driver in Budd's trailer.] She will drop "The Meat Grinder" or "The Roaster".
Turn In: Exit trailer.
Aegisq3dm9 18:16, June 27, 2010 (UTC)


text:
Shaina Mote Loose Tee in Ink
Shaina Mote Loose Tee in Ink
The Loose Tee in Ink by LA-based Shaina Mote. Slouchy fit jersey tee with loop at center back and bias taped neck and shoulder seam. Fits true to size. Size 4 measures 22.5" aross the bust and 24.5" long. Made in the USA.
Saint Cloud
Talk about heaven sent. Houston's Saint Cloud boutique is full of lust-worthy jewelry, accessories and home goods. Creative Director Cecilia Marquez and her partner, Jessica Rodriguez, artfully curate the gorgeous shop to offer small luxuries produced with thought and care from all over the world.
Do you have questions about this product? We're here to help!


text:
From Johannesburg
Take the N12 national road to Witbank which becomes the N4 national road. Follow the N4 through Nelspruit and Malelane. About 2 km outside Malelane, take the turn-off to enter the Kruger National Park at the Malelane Gate where an entrance fee is payable. Please have your confirmation or voucher with you.
Once you enter Malelane gate, drive straight on the H3 road, for about 37 km and turn left at the "Jock Safari Lodge" sign. Then a 3 km dirt road and you are at the lodge. Distance from Johannesburg: +/- 458 km
Note: The camp is situated half way between Skukuza and Malelane gates approximately 35 km in both directions with only 3 km of dirt road. Due to the rules and regulations of the Kruger National Park, nobody is allowed on any Kruger National Park roads during the period of gates being closed. Therefore, guests must be at their destination by the time the gates?close.
|Nov, Dec, Jan, Feb
|Mar, Oct
|Apr, Aug, Sep
|May, June, July
Jock Safari Lodge is approximately 45 minutes to an hour from the Malelane gate and therefore we recommend that flights to / from Kruger Mpumalanga Airport (KMIA/MQP) are booked to:
- arrive before 14h30 on day of arrival
- depart after 10h00 on day of departure
Kindly contact the lodge on + 27 (0) 13 735 5200 should you require any assistance.
GPS Co-ordinates
Main Jock Lodge: S 25' 13.059' | E 031' 33.850'
Fitzpatrick's at Jock: S 25' 13.490' | E 031' 34.007'
Central Reservations are able to arrange your transfer by air or by road.


text: The M'Tar are an alien race characterized by their short stature, large black eyes, and enlarged cranium, the M'Tar were native to the planet Rigel IX. Their skulls were punctuated by a short, thick horn which protruded from the center of their forehead. Their ears were short and pointed, and grew close to the skull. Despite the inhosptiable nature of Rigel IX's environment, the M'Tar managed to evolve and grow as a species and as a civilization. Their large eyes allowed them to see in the murky light. Rigel IX's constant tectonic activity instilled a sense of skepticism and pessimism, as the M'Tar cities were continually being rebuilt after natural disasters. A herbivorous race, the M'Tar were known to become violently ill should they consume any form of animal protein. Their technology mirrored that found in much of the galaxy, although they tended to build it on a smaller, more transportable scale. The basic tenet of M'Tar society was simple: plan for the worst, control all possible variables, and survive.


text:
Listing information
- Beds: 3
- Stories: 0
- Foreclosure: No
- Lot Area: 0.40
- County: Kalamazoo
- Style: Single Family
- Baths: 1 (Full: 1 3/4: 0 1/2: 0 Other: 0)
- Parking Type Description: Detached 1 car
- Total Square Footage: 1,204 ($107.97 per sq. foot)
- Lot Size: 66x132 78x109 2-lots
- School District: Kalamazoo
- Year Built: 1953
- Status: Active
- New Construction: No
- Above Ground Sq. Feet: 1,204
- Estimated Annual Taxes: $2,212
- Subdivision: K07 - Westwood-Nw Kalamazo
Access Feat: Accessibility Features No
Additional Items All Window Treatments, Garage Door Opener
Air Conditioning Central
Appliances Dishwasher, Microwave, Oven, Range, Refrigerator, Washer
Basement No
Design Ranch
Driveway Paved
Exterior Features Deck(s), Fenced Back, Patio
Exterior Material Aluminum, Brick
Fireplace No
Garage Type 1, Detached
Garage: Garage Yes
Heat Source Natural Gas
Heat Type Forced Air
Kitchen Features Eating Area, Pantry
Landscape Flower Garden, Garden Area, Ground Cover, Shrubs/Hedges
Lot Description Corner
Manufactured: Manufactured Y/N No
Mineral Rights Unknown
Other Lower Rooms: Lower Half Baths - 0, Lower Rooms: Lower Bedrooms - 0, Lower Rooms: Lower Finished SQFT - 0.00, Lower Rooms: Lower Full Baths - 0, Lower Rooms: Total Lower SQFT - 0.00, Main Rooms: Main Bedrooms - 3, Main Rooms: Main Full Baths - 1, Main Rooms: Main Half Baths - 0, Main Rooms: Main Level SQFT - 1204.00, Road Frontage - 144.00
Pool Outdoor/Inground
Property Sub-Type Single Family Residence
Roofing Comp Shingle
Sale Conditions None
Street Type Paved, Public
Substructure Slab
Terms Available Cash/Conventional, FHA, VA Loan
Util Avail at Street Broadband, Cable, Electric, Natural Gas, Public Sewer, Public Water, Storm Sewer, Telephone Line
Utilities / Sewer Public
Utilities Attached Cable, Natural Gas, Telephone Line
Water Heater Natural Gas
Water Type Public
Windows Replacement
Bedroom 2 M x
Bedroom 3 M x
Family Room M x
Kitchen M x
Laundry Room M x
Living Room M x
Master Bedroom M x
Listing Courtesy of Wayne T Caldwell of Doorlag Realty Company


text:
Accounting and Finance Tests
"How can I be sure that the applicants have the knowledge we need?"
Interviewers cannot be familiar with every possible skillset for every position. This results in the problem of evaluating a candidate's potential without fully knowing if the candidate is a good fit. Our Accounting and Finance tests will tell you what they know and, more importantly, what they don't know.
What Tests Can I Choose From?
- Accountant (TOPICS-left)
- Accounts Payable (TOPICS-right)
- Accounts Receivable (TOPICS-left)
- Advanced Accounting
- Bookkeeper (TOPICS-right)
- Business Documents
- Cost Accounting
- Credits and Debits
- Math Skills
- Payroll
- Taxes
- Terminology
- Peachtree Accounting (8.0, 9.0)
- QuickBooks (2010, 2006, 2005)
- Data Entry – Checks, Decimals
- Bank Teller – Money Handling
- Consumer Finance
- Credit & Collections
- Financial Analysis
- Financial Management
- Financial Knowledge
- Insurance
- Health Insurance
View a Sample Report Here
How Will I Know Which Tests To Administer?
Our Test Consultants will first learn from you more about the Key Success Factors (KSFs) for that specific position. The KSFs will point us toward the essential factors that ensure an employee's success in that position. Armed with that knowledge, tests will be chosen from the Accounting test series. Benchmarks can be set with current employees as needed.
Tell Me More About The Questions.
Questions are multiple choice and short answer format, requiring test takers to answer knowledge questions as well as calculate mathematical answers to common accounting problems. Each test has approximately 40 questions. These tests have been created by subject matter experts who identified the most important topics and tasks in the accounting and finance fields. Questions include real-world examples and illustrations to accurately measure a candidate's abilities.
How Will The Score Reports Be Displayed?
Score Reports are available immediately at end of test. No faxing, emailing or hand-scoring is necessary. Scores are available on screen or can be emailed to your organization's Test Administrator. The Score Reports will be in-depth, providing scores and detailed descriptions of a candidate's knowledge. Overall scores (by percentage) will be followed by scores for each topic.
How Much Does It Cost?
Pricing is generally on a "per test" basis and larger quantities are eligible for volume discounts. Here's the link to the pricing.
I'd like to see a sample and/or have more questions. What do I do?
Just complete our contact form above and we'll contact you to learn more about your needs. Or just visit our FAQ. For immediate questions, please call 1.800.836.1901.


text:
Beer is a drink found in Fable, Fable: The Lost Chapters and Fable II. It is an alcoholic drink, which has the ability to make one drunk if they drink too much of it.
Fable and TLCEdit
In Fable and Fable: The Lost Chapters, one will have their sight affected giving the game a very blurred and dizzy effect. One will also throw up.
Fable IIEdit
In Fable II, there are different types of beer. These are:
- Hoptimus Prime is obviously named after the Transformer Optimus Prime, a reference further supported by the item's description.


text:
Country Inn & Suites By Carlson, Columbia Airport, SC
2245 Airport Boulevard
Cayce , SC 29033
Off I-26, the Country Inn & Suites By Carlson®, Columbia Airport, SC welcomes you to its location near Columbia Metropolitan Airport (CAE). After your flight, you can hop on our complimentary shuttle to reach the hotel. In town to see the Gamecocks play? The University of South Carolina is nearby, along with other downtown attractions like Riverbanks Zoo. If you need to decompress after a long drive, slide into the water of the hotel's indoor pool.
See what our guests are saying about us.
Hotel Amenities & Services
Traveling for business? We offer a business center, open 24 hours, as well as express check-in and check-out, perfect for helping you get to the airport on time. Amenities and services include:
Learn more about our hotel's amenities and services.
Our Rooms & Suites
When you're ready to relax after a visit to USC or the zoo, kick back in a guest room or suite. Keep drinks and snacks for the kids handy in the fridge, and give your teens some space by reserving adjoining rooms. Standard room amenities include:
In Columbia for a few weeks on business? Then opt for an Extended-stay Suite, featuring all standard amenities as well as these extras:
Where to Eat While You're Here
Start your day with a hot waffle and coffee at the hotel's complimentary Be Our Guest Breakfast. For lunch and dinner, try a nearby restaurant like Lizard's Thicket, serving West Columbia's favorite homestyle cooking. Be sure to sample the southern fried catfish, one of the restaurant's most popular dishes. Love the sweet tea? Take it home by the gallon!
Things to Do in West Columbia, SC
If you have a few hours before your flight, you can explore what the city has to offer. Watch the antics of sea lions and penguins at Riverbanks Zoo & Garden, or wander through the antique shops and artisan vendors at the riverside Congaree Vista. Check out these other local attractions:
EdVenture – About five miles from the hotel, this hands-on museum inspires a love of learning. Your kids can become a vet for the day, tinker with their own wind-powered creations, and uncover the secrets of DNA in a real lab at the largest children's museum in the South.
SC Capitol Building and State House – See history in the making at the South Carolina Capitol Building and State House, where you can listen in on a house session before touring the granite capitol that took over 50 years to build. Take home a piece of history from the gift shop, which sells SC's official state dinnerware.
University of South Carolina – Even if you're not a prospective student, be sure to visit the 200-year-old campus of USC, less than 15 minutes away. While there, you can walk through the Horseshoe, the site of the original college that's now a park, or join 80,000 screaming fans for an SEC football game.
Read more about our hotel's location.
Groups & Meetings
If you're in West Columbia with a sports team or business group, the Country Inn & Suites offers group rates to make your stay affordable and convenient. Take advantage of the hotel's complimentary shuttle service to Columbia Airport, and let our staff make your group feel welcome.
Learn more about our group accommodations.
100% Non-Smoking Facility
Reserve a Room in Gamecock Country
Whether you are in town to see the Gamecocks, tour USC's lively campus or visit your student, the Country Inn & Suites, Columbia Airport makes an ideal home base. Located near I-26 and offering affordable rates, your home-away-from home is minutes from Columbia Metropolitan Airport (CAE) and the University of South Carolina as well as downtown Columbia's top attractions.
At our hotel, you can enjoy amenities like free high-speed Internet access, a free hot breakfast and a complimentary airport shuttle. Our heated indoor pool is perfect for a rejuvenating swim, and our in-room TV channels can help you relax before bed. Planning to tour the USC Columbia campus? Find convenient directions to the school from our hotel.
Discover more about the University of South Carolina online now:
Schools within USC:


text:
Audix D2-Trio
Microphone Set
- Set of 3 pieces
- Dynamic microphones specifically for toms
- Suitable for conga, bongo, guitar, woodwinds/ brass, percussion etc.
- Polar pattern: hypercardioid
- Frequency range: 44 - 18,000 Hz
- Impedance: 250 Ω
- Max. SPL 144 dB
- Including D-vice: gooseneck mounts and transport bags
Further information
|Incl. Clip On Mount
|Condenser Microphone
test results:
Smart Navigator
- go to product group Microphones for Toms
- go to product group Microphones for Drums
- go to product group Instrument Microphones
- go to product group Microphones
- show manufacturer details for Audix
- Audix Microphones at a glance
- printer friendly version of this page
Further Audix items
Offers include 21% Belgium VAT and are valid as long as stocks last. Shipping costs to Belgium are 2,50 EUR, free shipping on orders above 49 EUR. Please click here for international Shipping rates. We do not accept liability for typographical errors or inaccurate information of any kind. *RRP = manufacturer's / distributor's recommended retail price in Germany


text:
Dead by Daylight Keygen (Crack) – CD key for PC
Play in Dead by Daylight – Generate your key
download link –
Enjoy the game.
Dead by Daylight is a multiplayer (4vs1) horror game where one player takes on the role of the savage Killer, and the other four players play as Survivors, trying to
Dead by Daylight Keygen (Crack) – CD key for PC
How to install:
1. Download and run exe file
2. Press Install button
3. Choose destination folder
4. Press Finish
How to Use:
Open destination folder and locate file notes.txt, open it and read step by step.
Download nowDirect download link (Windows) ]


text:
Many people seem to believe that there is some major need to compromise on some aspects of gun control. While the recent tragedies certainly need to be looked at closely and methods put in place for preventing or dealing with such crimes, is more gun control really the answer? For the time being, there seems […]
Posts Tagged ' Gun Registration '
Conservative conservative women Cruz debate Democrat Dewhurst DREAM Act education Elle Magazine energy ESPN feminism Freedom of Speech GOP primary Governor Perry Hank Williams Jr higher ed reform Hispanic Voters Houston How Obama Got Elected HR 2587 immigration Lt. Governor Dewhurst NLRB Obama Obama voters Occupy Houston Palin Paul Perry President protest Rep Tim Scott Republican Senate whip Senator Dan Patrick Sen Cornyn Sen Kyl Tea Party Texas Texas DREAM Act Texas lege Texas Puentes Initiative Texas unemployment Zogby
Gun Registration and Compromise
February 3, 2013


text:
What is JotForm?
JotForm is a free online form builder which helps you create online forms without writing a single line of code. No sign-up required.
At JotForm, we want to make sure that you're getting the online form builder help that you need. Our friendly customer support team is available 24/7.
We believe that if one user has a question, there could be more users who may have the same question. This is why many of our support forum threads are public and available to be searched and viewed. If you'd like help immediately, feel free to search for a similar question, or submit your question or concern.
Integrate e-Signature widget form on existing Asp.net Website.Asked by Rohit on October 19, 2015 at 04:13 AM
JotForm Support
Hi Rohit,
Yes, this is possible. You can embed your form created in JotForm in your website by using the iFrame embed method. To get the iFrame embed code of your form, you can check the instructions in the screenshot below.
Do let us know if you need further assistance.
Hi Chriistian,
Thanks for you reply. Actually I want Form will be create on my website , I want only to integrate e-sign functionality.
I want user give online signature and signature image will save on my local, After that i will use that image where ever we want.
Rohit Gupta
JotForm Support
Hi Rohit,
Unfortunately, you can only use the e-signature widget by adding the widget in your form in JotForm. However, the value/data for the e-signature widget can be found to your JotForm account. If this is still not feasible, I think JotForm is not the one you need on your website, you can try to search plugins that can be used in your website. You can check these articles:
Do let us know if you need further assistance.


text:
Thanks to Trendsylvania & Notorious Mag I had the chance to visit one of the fashion hot spots – Berlin and it's famous Mercedes-Benz Fashion Week. From 19 to 23 January, the German and international fashion scene gathered once again in Berlin to the Fall/Winter 15-16 shows. This is the 8th year of Berlin fashion week, actually a young pal among the others fashion weeks, like Paris, London and New York, but full of its own personality.
I landed in Berlin and went directly to Lena Hoschek show, who is well known for her passion for traditional tailoring, 50′s and pin-up girls style. Lena Hoschek's Fall/Winter 15 collection was expectedly romantic and truly feminine. From A-line to pencil cuts, the designer's dresses and skirts were permeated with flower patterns and tulle. Although the collection remained more on the dark shades mainly dark blue, black and grey – flaming red and flower print found their way to sooth off its romantic side and give it a sexy touch. A great surprise for the big finish was an amazing wedding gown for the bridal collection. Champagne shades and a long veil earned ovations from the crowd. I'm pretty sure there was no woman in the audience who didn't picture herself in that beautiful dress at least for a second.
Check out the video:
Lena Hoschek's team also did an amazing job with her generous goodie bags for the whole crowd, not only the first row! A book, a pair of socks, a beautiful necklace, an amazing catalog and many more. I'll let you check my bag, but I'm keeping it all for myself Btw, loveee the chocolate packaging!
Like always, one of the funniest part of attending a big event is to choose what to wear. Berlin is underground, alternative, ultra relaxed, but I AM a fashionist, not a hipster. So I've chosen to be honest with myself and keep my style. Have a look, hope you like it.
Look 1:
Faux fur coat – Zara, Turtleneck – Mango, Bag – Zara, Hat – Zara, Jeans – Zara, Sunglasses – Karen Walker, Shoes – Lazzarini/Humanic
Look 2:
Blazer – Max Mara, Dress – Zara, Bag -Mansur Gavriel, Boots – Guess/Humanic
Wait for more #berlinfashionweek posts…I have much more to tell you


text:
The Doors- Five to One MP3
From album Live at the Aquarius Theatre: The second performance (disc 2)
The Doors - 5 to 1 (with lyrics) MP3
5 to 1 by The Doors Lyrics: Yeah, c'mon Love my girl She lookin' good C'mon One more Five to one, baby One in five No one here gets out alive, now You get ...
The Doors - Five To One MP3
'Five To One' is the eleventh song from The Doors album 'Waiting For The Sun'. 'Waiting For The Sun' is released in 1968. Lyrics: Five to one, baby, one in five, ...
The Doors - Five To One (subtítulado en español) MP3
http://www.facebook.com/desterratorializado.flores Five To One canción que cerraba el álbum "Waiting for the sun" suponía otra aproximación de Jim a la ...
The Doors : Five to one with lyrics MP3
The Doors : Five to one with lyrics.
The Doors 06 Five to One Absolutely Live MP3
The Doors 06 Five to One Absolutely Live jim morisson.
The Doors - Five To One (w/Lyrics & Sub. Español) MP3
Cinco A Uno es el tema final del álbum Waiting For The Sun, es un grito de Guerra que comprende algo que se consideró algo violento en esas épocas hoy The ...
The Doors - Five To One [scene from movie] HD MP3
FOR ENTERTAINMENT PURPOSES ONLY!! NO COPYRIGHT INFRINGEMENT INTENDED HERE!! I DO NOT OWN ANY PART OF THIS VIDEO! The Doors ...
Iggy Pop - Five Foot One MP3
Music video by Iggy Pop performing Five Foot One. (C) 1979 Sony Music Entertainment UK Limited http://vevo.ly/XeX4YL.
Five Foot One
Iggy PopYeah, I like it Ugh! Ugh! Ugh! I'm only five foot one I got a pain in my neck I'm looking up in the city What the hell what the heck I stare at the concrete The girders [...]
Hi-Five - As One MP3
As One / Hi-Five Written by Timmy Allen, Anthony Beard Produced, Arranged by Timmy Allen *1993 from the 3rd studio album "Faithful" (October 15, 1993) Jive ...
Hollywood Vampires - Five to One / Break On Through (to the Other Side) MP3
Hollywood Vampires - Rock In Rio Brasil 2015. The Hollywood Vampires are: Johnny Depp, Joe Perry, Alice Cooper, Duff Mckagan and Matt Sorum.
The Doors Five To One Live at Miami "Dinner Key Auditorium" 1969 MP3
Break On Through To The "The Doors Portal" https://www.facebook.com/TheDoorsPortal https://twitter.com/TheDoorsPortal Watch The New Video: The Doors ...
Marilyn Manson - Five to one (Doors Cover) (With Lyrics) MP3
Cover of the Doors - Five to One by Marilyn Manson. Robbie Krieger recorded a version of this song with Marilyn Manson for the 2000 Doors tribute album ...
Deorro- Five Hours (One Hour Version) MP3
Five K One 2010) MP3
FIVE-K-ONE Movie Premiere. Five K One a vicious and dangerous movie about life in the fast lane that cross paths with a snitch, a cop, and the decision of a ...
Film Thirty Five to One ( 35 to 1 ) MP3
Tele film Thirty-Five to One (35 to 1). From Luthfur Rahman, the writer and director of Keetha Pyelam, Keetha Oilow & Keetha Bujlai.
The Doors Ft. Scott Weiland (Stone Temple Pilots) - Five to One (LIVE) MP3
Nice ..
The Doors - Five To One 1080 HD MP3
five to one by the doors... mucho passion i don't own any rights to this song.
Disfrutando Disney con One Five MP3
One Direction - Four Five Seconds (COVER) #1DR1LiveLounge MP3
THIS IS THE BEST THING I'VE EVER SEEN. I'M DEAD. twitter: @greenstyles5.
Ben Folds Five - One Angry Dwarf and 200 Solemn Faces MP3
Music video by Ben Folds Five performing One Angry Dwarf And 200 Solemn Faces. (C) 1997 SONY BMG MUSIC ENTERTAINMENT.
One Angry Dwarf And 200 Solemn Faces
Ben Folds FiveSeptember '75, I was 47 inches high My mom said by Christmas I would have A badass mother GI Joe for your little minds to blow I still got beat up after class Yeah, now I'm big and important[...]
Maroon 5 - One More Night MP3
Buy Now! iTunes: http://smarturl.it/1545s2 Amazon: http://smarturl.it/sxgjyq Music video by Maroon 5 performing One More Night. (C) 2012 A&M/Octone Records.
One More Night
Maroon 5Ooh, ooh ooh ooh, ooh ooh ooh ooh Ooh, ooh ooh ooh, ooh ooh ooh ooh You and I go hard at each other Like we're going to war You and I go rough, we keep throwing things And slamming the door You and I get so damn dysfunctional We start keeping score You and I get sick, yeah I know that we can't do this no more, yeah But baby, there you go ag[...]
Marilyn Manson - Five To One MP3
[LYRICS:] Marilyn Manson - Five To One Five to one baby one in five No one here gets out alive now You get yours baby I'll get mine Gonna make it baby if we ...
Iggy Pop - Five Foot One MP3
Studio version with a slide show. From his 1979 album "New Values".
All for One - Hawaii Five-0 MP3
Last scene from 100th Hawaii Five-0's episode! Song from Five For Fighting.
What If Bears Killed One In Five People? MP3
Guys, this angry, hungry bear in our house is a big problem. You wouldn't put up with that. So don't put up with this. 1 in 5 women will be sexually assaulted by ...
The Doors - Five to One (HQ) MP3
The Doors.
Beyoncé Ring The Alarm incl 'Five To One' & 'Takeover', 'Independent Women', MP3
The Doors IL FILM Live a Miami TRACCIA AUDIO Five To One MP3
The Doors IL FILM TRACCIA AUDIO in lingua Inglese LA FAMIGLIA DOORSIANA GRUPPO DI FACEBOOK LINK ...
300 - Marilyn Manson (The Doors) - Five To One MP3
Videoclip Imágenes: 300 Música: Marilyn Manson - Five to One (The Doors Cover) Montaje by T3rmy.


text:
Captian Blade is the seventh boss in Skip and Sqak TV Game. He is the Captian of the pirates sailing in Blood Water Ocean. He is hired by Rexes to make the SSFF "Shark Food".
Captian Blade is the most dangerous pirate in his own crew. Anyone either thief, stow away, or intruder has to walk the plank and into the water, where they get eaten alive by sharks. When Rexes came to his world, he bribes Captian Blade 1 000 000 coins to kill off the SSFF. Blade accepts, and decides to turn the SSFF into "Shark Bate".
The SSFF arrived in the Blood Water world to stop Captian Blade. When they got to his Ship, Captian Blade sends his pirate crew to attack, but they defeated the pirate crew and battled Captian Blade on top of the Crow's Nest. The SSFF pushed Blade far enough off the nest and falls into the water, where he gets attacked by sharks. It was unkown if he survived the attack.