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New Delhi: Cheering up the economy further, the core infrastructure industries grew by 7% in October against 3.9% in the same month last year, helped by robust performance of cement and crude oil sectors, reports PTI.
The October data for six industries-crude oil, petroleum refinery products, coal, electricity, cement and finished steel-reflected a bounce back from September when growth in these sectors had plunged to 2.7% against 4.3% growth in corresponding period in 2009-10.
Core infrastructure industries that have a weight of 26.7% in the Index of Industrial Production (IIP), is expected to show a positive impact on the October IIP, likely to be released next month.
Revival in the core industries comes on top of 8.9% growth in the country's gross domestic product (GDP) for the first half of the current fiscal.
Expansion of the economy, helped by impressive performance by the industries, including the infrastructure sector, is expected to give a boost to investment climate, HSBC Group country head Naina Lal Kidwai said.
"We will see more investments by industry next year because in lots of companies capacity utilisation is 90% plus," she said.
However, amid the overall good performance of core infrastructure activity, coal and petroleum refinery output remained areas of concern. While petroleum refinery products showed a deceleration of 4.8%, coal could barely grow by 0.8% in October.
Cement with 16.8% and crude oil with 13.7% growth emerged as the top infrastructure performers in October.
The April-October cumulative performance remained unchanged at 4.5% from the previous year.
Reacting to the core sector data, principal economist with credit rating agency CRISIL DK Joshi said the slowdown in coal output was a cause of concern as it will have an impact on electricity generation.
He said the six infrastructure sectors are likely to register 6%-7% growth in the coming months.
As per the data released by the industry department, electricity generation increased to 8.4% in October against 4.4% in the comparable month last year. Output of finished steel, too, improved at 6.2% from 2.5% in October 2009.
During April-October period, crude oil sector registered a growth of 10.7% against a contraction of 1.3% in the same period last fiscal.
However, coal output in the first seven months of 2010-11 contracted by 0.1% from a positive growth of 11.4% in April-October 2009-10.
On a cumulative basis, electricity generation and cement also slowed to 4.7% and 6.3%, respectively in April-October from 6.1% and 11.3%, in the same period last year.
The data further said petroleum refinery output in the period expanded by 1.4% and finished steel by 4.2%.
The Bimal Jalan committee's proposal to kill the listing dreams of stock exchanges, ignites fears among big investors in the bourses and BSE brokers that billions could vanish overnight
Several high-profile private and institutional investors in the national bourses could be left high and dry if the proposed recommendations of the Bimal Jalan committee are accepted as they are. Together, these investors have put in a stupendous Rs11,000 crore in various bourses at the national and regional level, on the hope that these exchanges would go public one day. However, the Jalan committee has effectively scuttled their dreams of making money on their investments, by frowning upon the listing of stock exchanges.
The Bimal Jalan committee, which was appointed by the Securities and Exchange Board of India (SEBI) to report on the structure of market infrastructure institutions, has proposed that such entities should be prohibited from getting listed. It argues that self-listing may lead to misgovernance. Classifying stock exchanges as 'public utilities', the seven-member panel says that fluctuations in stock prices of exchanges would be detrimental to the market as a whole.
But this proposal will leave a bunch of institutional investors fretting and biting their nails nervously. In the absence of a public offering, these investors could struggle to exit their holdings with reasonable gains. Along with a host of broking firms, institutional investors had poured in substantial funds into the bourses.
According to reports, the National Stock Exchange (NSE) attracted as much as Rs6,500 crore from private investors, among them such big-ticket institutions like Goldman Sachs and the New York Stock Exchange. The Bombay Stock Exchange (BSE) also managed to rake in Rs3,500 crore from several intermediaries, despite its floundering business operations. Regional bourses also received funds to the tune of Rs1,000 crore.
The interest in having a stake in the premier stock exchanges is undoubted. These are some of the most profitable institutions in the country - a fact that has enabled them to attract so much attention from foreign institutions in the past. Last year, the NSE reported a net profit of Rs614 crore while the BSE posted Rs232 crore as profit for the same period. However, with this startling announcement, the stock exchange space suddenly appears less attractive. How would the exchanges be able to attract fresh investments if the lure of huge gains on exit has vanished?
These investors would have been hoping to earn robust returns on their investments once the exchanges accessed the primary markets. For, even if there were no plans for listing, institutional investors were able to sell their shares to each other over the last two years in the hope that they would be listed some day.
While the market opened with a negative bias tracking the Asian bourses, the GDP growth numbers for the September quarter along with buying in second-rung stocks ensured a green close for the second day running.
The market opened in the red, tracking its regional peers that were trading lower on concerns about the pace of the global recovery process. It traded in a narrow range till noon, with the strong gross domestic product (GDP) numbers for the second quarter giving the indices the much-needed boost, pushing them up into positive territory.
Buying in the broader market in the post-noon session propelled the market further northwards to the day's high. However, a minor bout of profit-taking saw the indices paring some gains but closing around half a percent higher.
The Sensex closed 116.15 points (0.60%) up at 19,521.25. The index touched an intraday high-low of 19,610.46 and 19,218.02. The Nifty settled at 5,862.70, 32.70 points (0.56%) higher. The barometer touched a high of 5,892.25 and a low of 5,768.35.
The market breadth was mixed today. While the Sensex had 26 declining stocks against four gainers, the Nifty closed with 32 advancing stocks and 18 losers. The broader indices outperformed the key benchmarks. The BSE Mid-cap index surged 1.39% while the BSE Small-cap index jumped 1.90%.
The top Sensex gainers included DLF (up 7%), Bharti Airtel (up 6.45%), Tata Motors (up 4.31%), State Bank of India (up 3.97% and Reliance Communications (up 3.41%). Tata Steel (down 1.48%), Reliance Industries (down 1.14%), ICICI Bank, Tata Power (down 0.90% each) and Larsen & Toubro (down 0.89%) were the notable losers today.
BSE Realty (up 5.67%), BSE Consumer Durables (up 2.08%), BSE Power (up 1.84%), BSE Public Sector Undertaking (up 1.73%) and BSE Fast Moving Consumer Goods (up 1.38%) were the key performers in the sectoral space. BSE Oil & Gas (down 0.56%) was the lone sectoral loser today.
Driven by good performance of agriculture and manufacturing, the Indian economy grew by 8.9% in the second quarter of the current fiscal, up from 8.7% in the corresponding period a year ago.
The growth rate for the first quarter was revised upwards to 8.9% from 8.8% as estimated earlier. This took the overall economic expansion during the first half (April-September) to 8.9%, up from 7.5% in the corresponding period a year ago.
Markets in Asia settled mostly in the red on speculations that China would hike rates further to keep a firm tab on inflation and on the continuing European debt crisis.
The Shanghai Composite tumbled 3.11%, the Hang Seng shrank 1.11%, the Jakarta Composite tanked 1.72%, the KLSE Composite was down 0.31%, the Nikkei 225 declined 1.48% and the Straits Times shed 0.53%. On the other hand, the Seoul Composite gained 0.65% and Taiwan Weighted added 0.06%.
Finance minister Pranab Mukherjee said International Monetary Fund (IMF) may prove correct in its assessment of India's economic growth, given the second quarter growth rate of 8.9%, which has surpassed the assessment of various experts.
"I always go by conservative estimates... As per IMF (International Monetary Fund) estimates, the GDP growth would be more than 9%...IMF may be correct this time," Mr Mukherjee said while commenting on the second quarter growth figures announced earlier in the day.
The US markets closed weak on Monday as lingering concerns over the lingering debt crisis in Europe weighed on investors' minds. Besides, the European Commission said it expects weak global markets and government efforts to cut deficits to bring a "gradual and rather uneven" recovery across the region's 27 member states. On the positive side, US retail sales during Thanksgiving weekend totalled about $45 billion, the National Retail Federation said, quoting a survey conducted by BIGresearch.
The Dow declined 39.51 points (0.36%) to 11,052.49. The S&P 500 shed 1.64 points (0.14%) to 1,187.76. The Nasdaq fell 9.34 points (0.37%) to 2,525.22.
Back home, foreign institutional investors were net buyers of Rs156.20 crore in the equities segment on Monday and domestic institutional investors net buyers of Rs199.33 crore on the same day.
Drug major Ranbaxy (up 1.01%) today said it had received final approval from the US health regulator to manufacture and market generic Donepezil Hydrochloride tablets used for treating Alzheimer's disease with 180 days market exclusivity.
The approval for Donepezil Hydrochloride tablets has been given by the US Food and Drug Administration (USFDA) in the strengths of 5 mg and 10 mg, company said in a filing to the Bombay Stock Exchange (BSE).
IT services firm Spanco (up 5.21%) today said it had received a Letter of Intent (LoI) from the Bihar government to implement IT infrastructure for the state's electricity board with an order value of Rs160 crore.
The project has been awarded under the Re-structured Accelerated Power Development and Reform Program (R-APDRP).
State-owned BHEL (up 2.35%) has bagged an order worth Rs3,700 crore from Karnataka Power Corporation Ltd (KPCL) to supply the country's first super critical 700-MW coal fire unit for its thermal power station (TPS) at Bellary.
Bellary TPS is already equipped with a 500-MW unit supplied by BHEL and another unit with the same capacity is under execution.


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Out with the old, in with instability
Last month, David Li Kwok-po, a long-time representative of the banking industry on the Legislative Council, announced that he would not seek re-election. 'The past 27 years was a waste of time,' Li complained. 'I wish I had never entered politics, and I would ask my sons not to do so.' What caused Li to take such a dim view of politics after so many years of being a prominent part of the system?
One explanation for the unhappy end to another incestuous affair between business and politics is the upending of the old bureaucratic system. Once upon a time, government officials were promoted purely based on experience and competence in true Weberian fashion. They could reach ministerial positions purely by dint of technocratic merit.
The government was a stubbornly hierarchal organisation that valued technical superiority above all else. Civil servants could expect to move up every few years, and deviations occurred only due to extreme performance or luck. Thus, it was easy for the city's business elites to cosy up to the government's ruling class, which featured a cast of regulars that exited the stage only at retirement.
Contest for the government's top job, as we have seen in the last chief executive election, however, introduced uncertainty to every level of government. Despite complaints that the race was essentially a choice between two bad options ('the less unpopular candidate won', an article concluded), the election did produce an unexpected outcome and an element of unpredictability.
In this new reality, businesspeople hoping to gain favour with the next chief must participate in some form of political horse-betting. Speculators who back the wrong candidate may find themselves grumpily disillusioned and cut off from political influence.
The same can be said of government hopefuls vying for a piece of the pie, as loyal supporters of the new chief - mostly outsiders and political underdogs - are tipped to play prominent roles in the next administration. The fact that these political appointee jobs are open to everyone, including young people without a university degree or civil service experience, signifies the declining importance of traditional bureaucratic competence.
More than 1,000 people have put their names in the hat for the highly sought-after positions, competing to woo chief executive-elect Leung Chun-ying with their vision of Hong Kong's future development. In forming his own team with people he likes and replacing principal officials, undersecretaries and political assistants all in one strike, Leung brings us one step closer - as his predecessors did - to politicising the government's top-level leadership.
There are many implications for people seeking opportunities within this new structure. While the political tier is here to stay, individuals appointed to these positions are not. The public is determined that the chief advantage and impetus of the public accountability scheme are increased accountability. Since the appointments are political in nature, public scrutiny will bring instability to these jobs.
In the current Legco debate on the incoming chief's restructuring plans for the government, a burning issue is how a minister who underperforms should be made accountable. Should he or she be demoted, have his or her salary cut, or be made to bow out? Clearly, public expectation is such that an appointee who loses favour in the eyes of the people and becomes a political liability to the chief executive will be quickly relieved of his duties. The contract system and the availability of a large pool of outside talent supposedly make it much easier to do so than in the past.
This general sentiment is evident in the recent controversies surrounding corruption among high-ranking government officials. It is surprising to no one that many members of the business elite have both lawfully and unlawfully bought political influence from willing participants.
Nonetheless, as government becomes less bureaucratic and more influenced by politics, officials are expected to provide leadership in policy as well as morality. Thus, intense public outrage erupted over Chief Executive Donald Tsang Yam-kuen's greedy habits, with many calling for punishments much harsher than the actual crime.
As this article goes to print, more businessmen and former officials in the camp of disgraced chief executive hopeful Henry Tang Ying-yen are coming to grief over alleged corruption in Hong Kong or Macau or other manifestations of poor performance, fuelling a conspiracy theory that the retribution game is on. Whatever happened, call it retribution or simply the withdrawal of protection by the powers-that-be, a reshuffle of the deck upon the election of a new leader is likely to be the shape of things to come.
After all, a transfer of power, with all that it implies in terms of who goes up and down, is what periodic democratic elections are supposed to bring. Democracy is supposed to usher in greater equality, transparency, accountability and social justice. But also unpredictability, instability, and trade-offs with efficiency and bureaucratic reliability.
The new system, which promises salvation to many, comes as a shock to those still living in the old system, like David Li. As Hong Kong people soldier on in the long march to democracy, let us be crystal clear about all the changes - some more desirable than others - that democracy might entail.
Regina Ip Lau Suk-yee is a legislator and chair of the New People's Party
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subset: commoncrawl


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Mechal Production Industries
Designing and manufacturing military hardware
|Targetted locations
|Gammetan Military
|Major products
CEO Ghedgo
Mechal Production Industries, often referred to as Mechal or shortened MPI, is a major military design and manufacturer company for the Gammetan Civilization. It concentrates on vessels for the Gammetan Navy, however also has a smaller Air Force division. MPI has designed and produced, on its own, the majority of ships currently in use by the naval forces: Battleships, frigates, battlecruisers, and transports.
Early in its history, it focused on naval assets, designing the Lohaul Battleship and Gammetan Frigate, as well as contributing to Project Devlabordich. HelAux's domination of air force designs and MPI's domination of manufacturing assets lead to a friendly relationship pre-2011. However, it acquired Danga Corporation whilst they were developing the Danga Bomber for the 2011 bomber request, leading to MPI's entry in to the aviation industry. While the relationship subsided as they became competitors, the two remain cooperative. MPI has participated in both naval and air requests for proposals post-2011, and had success in both areas with three designs, winning the three competitions they entered, including the Mechal Fi-1. Gralage Advanced Production now enjoys a strong relationship with MPI, brought about by the former's speciality in smaller vessels and the latter's in large. The two are rumored to be in partnership or merger talks as of October 2012.


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(90 m2 / 972 SQ. ft. - 2 bedrooms & 2 baths) One Level Unit at The Ground Level
Boca Prins 1 Condo is a one-level corner unit on the ground-floor level with 2 bedrooms, 2 bathrooms and its own private backyard. It offers an airy, open floor plan that allows the kitchen, dining room, and living room to flow seamlessly together while maintaining individual identity.
(Click on pictures below to view larger images)


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GW Links
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Recruit interns, post jobs, conduct on-campus interviews, attend job fairs, and more. Contact Emmy Rashid, SEAS career services director, at firstname.lastname@example.com or 202-994-7892 for assistance.
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text: RAND: Alan J. Vick 2017-07-21T14:21:51Z Copyright (c) 2017, The RAND Corporation RAND Corporation https://www.rand.org/about/people/v/vick_alan_j.html Continuity and Contingency in USAF Posture Planning Alan J. Vick; Stacie L. Pettyjohn; Meagan Smith; Sean Zeigler; Daniel Tremblay; Phillip Johnson https://www.rand.org/pubs/research_reports/RR1471.html 2016-11-18T05:30:00Z 2016-11-18T05:30:00Z This study develops a framework for long-term U.S. Air Force (USAF) posture planning that accounts for drivers of USAF posture and identifies steps the USAF can take to increase posture robustness and agility over the 30-year planning period. Proclaiming Airpower Alan J. Vick https://www.rand.org/pubs/research_reports/RR1044.html 2015-07-17T08:00:00Z 2015-07-17T08:00:00Z Examines how U.S. Air Force narratives and public attitudes toward civil and military aviation have evolved and interacted over the past century. Air Base Attacks and Defensive Counters Alan J. Vick https://www.rand.org/pubs/research_reports/RR968.html 2015-06-12T05:15:00Z 2015-06-12T05:15:00Z This report provides a reference on air-base attack and defense, describes the post-Cold War American way of war, identifies defensive options, and offers recommendations on how best to win the battle of the airfields. U.S.-Japan Alliance Conference Series Proceedings Alan J. Vick; Rachel M. Swanger; Mark A. Lorell; Ryo Sahashi; Scott Warren Harold; Chad J. R. Ohlandt; Kazuto Suzuki; Cortez A. Cooper; Sugio Takahashi; Jeffrey W. Hornung; Andrew Scobell; Bruce W. Bennett; Narushige Michishita; Charles Wolf, Jr.; Jing Sun; Masahiro Kawai; Tom Cutler; Kazuhito Yamashita https://www.rand.org/pubs/presentations/PT138.html 2015-01-21T07:45:00Z 2015-01-21T07:45:00Z In a series of conferences, U.S. and Japanese experts explored the challenges for the U.S.-Japan alliance associated with China's military modernization drive and increasing foreign policy assertiveness. The Posture Triangle Stacie L. Pettyjohn; Alan J. Vick https://www.rand.org/pubs/research_reports/RR402.html 2013-12-05T06:00:00Z 2013-12-05T06:00:00Z Identifies why the U.S. Air Force (USAF) needs a global posture, where it needs basing and access, the types of security partnerships that minimize peacetime access risk, and the amount of forward presence that the USAF requires. Okinawa Remains an Intractable Thorn for US and Japan Stacie L. Pettyjohn; Alan J. Vick https://www.rand.org/blog/2012/05/okinawa-remains-an-intractable-thorn-for-us-and-japan.html 2012-05-25T15:00:00Z 2012-05-25T15:00:00Z The relocation of the Marines is a first step toward a more sustainable US military presence in the Asia-Pacific. Yet policymakers in Washington and Tokyo should not expect this move to eliminate an enduring source of tension in US-Japanese relations, write Stacie L. Pettyjohn and Alan J. Vick. Managing Risk in USAF Force Planning Frank Camm; Lauren Caston; Alexander C. Hou; Forrest E. Morgan; Alan J. Vick https://www.rand.org/pubs/monographs/MG827.html 2009-05-13T09:25:00Z 2009-05-13T09:25:00Z Presents a framework for force planning that would help guide Air Force leaders as they make the difficult decisions necessary to manage risk across multiple possible missions and between current and future priorities. A New Division of Labor: Meeting America's Security Challenges Beyond Iraq Andrew R. Hoehn; Adam Grissom; David Ochmanek; David A. Shlapak; Alan J. Vick https://www.rand.org/pubs/monographs/MG499.html 2007-04-08T16:29:00Z 2007-04-08T16:29:00Z The promotion of democracy and freedom abroad will continue to require changes in how U.S. armed forces are organized and employed and how the services relate to one another and to U.S. allies. America's Security Challenges Require a New Division of Labor Among the Armed Forces Andrew R. Hoehn; Adam Grissom; David Ochmanek; David A. Shlapak; Alan J. Vick https://www.rand.org/pubs/research_briefs/RB210.html 2007-03-27T20:11:00Z 2007-03-27T20:11:00Z This research brief assesses the primary challenges to U.S. security in the emerging security environment and offers suggestions for how the U.S. strategy and the defense program should be adjusted in order to meet these challenges. Building Partner Capacity Is the Key to a Successful Counterinsurgency Strategy Alan J. Vick; Adam Grissom; William Rosenau; Beth Grill; Karl Mueller https://www.rand.org/pubs/research_briefs/RB211.html 2006-08-31T13:32:00Z 2006-08-31T13:32:00Z This research brief examines ways the U.S. Air Force can contribute to allies' conterinsurgency efforts by providing advice; education; and, when necessary, physical and technological assistance to partner-nation air forces. Air Power in the New Counterinsurgency Era: The Strategic Importance of USAF Advisory and Assistance Missions Alan J. Vick; Adam Grissom; William Rosenau; Beth Grill; Karl Mueller https://www.rand.org/pubs/monographs/MG509.html 2006-08-16T09:19:00Z 2006-08-16T09:19:00Z History shows that an afflicted nation must itself defeat an insurgency politically and militarily, and the best way to help is to offer advice, training, and equipment. Beyond Close Air Support: Forging a New Air-Ground Partnership Bruce R. Pirnie; Alan J. Vick; Adam Grissom; Karl Mueller; David T. Orletsky https://www.rand.org/pubs/research_briefs/RB170.html 2005-11-25T07:57:00Z 2005-11-25T07:57:00Z Beyond Close Air Support: Forging a New Air-Ground Partnership Bruce R. Pirnie; Alan J. Vick; Adam Grissom; Karl Mueller; David T. Orletsky https://www.rand.org/pubs/monographs/MG301.html 2005-02-28T04:58:00Z 2005-02-28T04:58:00Z Creating a new partnership to integrate air operations with ground fire and maneuver more effectively on future battlefields. Aerospace Operations in Urban Environments: Exploring New Concepts Alan J. Vick; John Stillion; David R. Frelinger; Joel Kvitky; Benjamin S. Lambeth; Jeff Marquis; Matthew Waxman https://www.rand.org/pubs/monograph_reports/MR1187.html 2002-01-01T09:05:16Z 2002-01-01T09:05:16Z This study sought to help the USAF better understand how the urban physical, social, and political environment constrains aerospace operations and to identify key operational tasks that aerospace forces can help accomplish. The Stryker Brigade Combat Team: Rethinking Strategic Responsiveness and Assessing Deployment Options Alan J. Vick; David T. Orletsky; Bruce R. Pirnie; Seth G. Jones https://www.rand.org/pubs/monograph_reports/MR1606.html 2002-01-01T09:01:00Z 2002-01-01T09:01:00Z Assesses how rapidly the Army's new medium-weight Stryker Brigade can be deployed by air or sealift from planned bases in the United States versus forward bases in key regions and explores how rapidly large U.S. forces need to deploy. Meeting the Challenge of Elusive Ground Targets Alan J. Vick; Rich Moore; Bruce R. Pirnie; John Stillion https://www.rand.org/pubs/research_briefs/RB76-1.html 2001-12-31T21:00:00Z 2001-12-31T21:00:00Z Summary of "Aerospace Operations Against Elusive Ground Targets," which seeks to identify concepts and technologies that could improve the United States Air Force's capability to detect, classify, recognize, and defeat elusive targets. Aerospace Operations Against Elusive Ground Targets Alan J. Vick; Rich Moore; Bruce R. Pirnie; John Stillion https://www.rand.org/pubs/monograph_reports/MR1398.html 2001-01-01T09:01:46Z 2001-01-01T09:01:46Z This book seeks to identify concepts and technologies that could improve the USAF's capability to detect, classify, recognize, and defeat elusive targets, whether dispersed ground forces or mobile ballistic missiles. Preparing the U.S. Air Force for Military Operations Other Than War Alan J. Vick; David T. Orletsky; Abram N. Shulsky; John Stillion https://www.rand.org/pubs/monograph_reports/MR842.html 1997-01-01T09:01:38Z 1997-01-01T09:01:38Z To help the USAF better understand the effects of current MOOTW on training and readiness, to explore some options to reduce those effects, and to propose new concepts of operations to enhance USAF capabilities to accomplish future MOOTW tasks. The U.S. Air Force and Operations Other Than War: Reducing Current Stresses and Meeting Future Demand Alan J. Vick https://www.rand.org/pubs/research_briefs/RB48.html 1996-12-31T21:00:00Z 1996-12-31T21:00:00Z Study of USAF involvement in military operations other than war delineates the challenges facing the USAF at this optempo level and offers new approaches aimed not only at minimizing existing problems but also at enhancing USAF MOOTW capabilities. Finding Needles in Haystacks: Enhancing Air Power's Contribution Against Light Infantry Alan J. Vick; David T. Orletsky; John Bordeaux; David A. Shlapak https://www.rand.org/pubs/research_briefs/RB41.html 1995-12-31T21:00:00Z 1995-12-31T21:00:00Z Discusses the challenges posed by light infantry opponents and presents new operational concepts that may help meet such challenges.


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After 75 years of high-minded respectability, the Amelia Gower Women's Club is in trouble. One distinguished director has been strangled. Another has taken a fatal plunge down the club's elegant staircase.
As soon as restaurateur-sleuth Jane Lawless begins investigating these murders, wheels within wheels start to turn, meshing private lives with the club's inner workings. Even Jane's new lover, Dorrie, is somehow involved in the diabolical proceedings....
©1993 Ellen Hart (P)2013 Audible, Inc.
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text:
Listen to Justin Bieber's New Song, 'Recovery'
After meeting his "Heatbreaker," Justin Bieber is seeking some down time for his "Recovery."
As promised, the Candian crooner has another track as part of his #MusicMonday initiative. Biebs' latest slow jam features soft coos and a familiar guitar riff from Craig David's 2000 hit "Fill Me In."
Don't worry though, the British singer has given his blessings, tweeting, "So many great memories flood back when hearing this guitar riff. Well done @justinbieber sounding great."
Listen to JB's new song, above. Lyrics for the song are now on Directlyrics.


text:
Palm of Glove: M1 Mega Grip foam is high quality and extremely soft latex foam that has excellent properties for using in various weather conditions. 3D Thumb Crotch has rolled crotch construction between the thumb and the index finger. This eliminates any seams that can bother the keeper in an area that takes a lot of stress. The backhand base of the flexible and breathable mesh material is rolled to the palm which supports an ergonomic fit and increases wearing control. Backhand of Glove: Super Softi foam all over. Embossed foam design makes the glove more flexible at many breakpoints. The Wider Wrist Bandage gives the keeper a better fit and more control. Reusch's revolutionary Pro Flex technology offers excellent flexibility that improves the glove fit and performance. Reusch has combined specific stretch materials and applied our expert knowledge of soccer and glove technology to invent the best backhand flexibility and fit on the glove. Backhand Side wrap that wraps the backhand material around the side of the hand. This feature gives extra protection to the palm material and the keeper's side of hand. Construction: Roll Finger cut ESS uses a pattern that helps the fingers to be pre-splayed. This special Roll Finger cut style allow 100% of Reusch's M1 Mega foam on all points of contact for a maximum grip and control of the ball. AirVentSystem uses highly breathable Air Mesh material to make this glove more comfortable.
No size chart available for this product.


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151 NIKE GOLF DRI-FIT VERTICAL MESH POLOS Designed for the ultimate in performance, this polo has an understated vertical mesh texture. Dri-FIT moisture management technology provides breathable comfort during and after play. Made of 4.4-ounce, 100% polyester Dri-FIT fabric. DRI-FIT VERTICAL MESH POLO 637167 Features a self-fabric collar and three-button placket. A contrast Swoosh design trademark is embroidered on the left sleeve. ADULT SIZES: XS–4XL BLUSTERY VOLT PINK FIRE (LADIES ONLY) BRISK BLUE WHITE ACTION GREEN OLD ROYAL COOL GREY UNIVERSITY RED MARINE BLACK LADIES DRI-FIT VERTICAL MESH POLO 637165 Tailored for a feminine fit with a Johnny collar. A contrast Swoosh design trademark is embroidered on the left hem. LADIES SIZES: S–2XL POLOS/KNITS
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text:
Citation Edit
New Zealand Government, Ministry of Economic Development, Digital Strategy 2.0 (Aug. 28, 2008) (full-text).
Overview Edit
The New Zealand Government has integrated online risk and safety responses into this overarching strategy on the digital economy. The strategy coordinates programs that promote New Zealand's economic, technical and social performance in the digital economy. The strategy seeks to reduce online risk by creating a ". . . secure and trusted network and universal understanding of online safety, security and privacy issues."[1]
To achieve this goal the strategy commits the government to a series of actions to:
- ensure universal awareness of online safety, security and privacy
- ensure the security of digital infrastructure and networks
- enhance the security of digital information
- enforce privacy and cybercrime law.
Particular actions identify the delivery of programs, the responsible agency, timing and status.
References Edit
- ↑ Id. at 40.


text:
Mega Man Zero 2 (Rockman Zero 2 ロックマンゼロ2, Rokkuman Zero Tsū? in Japan) is the second of four games in the Mega Man Zero series for the Game Boy Advance, released in 2003.
The game was re-released in 2010 as part of the compilation game, Mega Man Zero Collection for the Nintendo DS.
Characters Edit
- Zero
- Ciel
- Alouette
- Cerveau
- Fighting Fefnir
- Sage Harpuia
- Fairy Leviathan
- Hirondelle - is a Reploid that goes around and gathers information for the Resistance, and gives hints to the player. One of his hobbies is composing poetry. He also appears in Mega Man Zero 3 and 4.
- Hyleg Ourobockle - Once a member of Phantom's Zan'ei Army, Phoenix is now under the command of Fefnir. Hyleg is a snake-like boss who Zero fights in the top of a giant Mechaniloid called Altoloid.
- Panter Flauclaws - Serving Harpuia, Panter is a boss that mainly uses electrical attacks and throws pink boomerangs.
- Phoenix Magnion - Another former member of Phantom's Zan'ei Army. He uses fire based attacks and confuses his enemies with illusions.
- Poler Kamrous - Serving Leviathan's Meikai Army, Poler attacks by slashing, throwing ice balls, and using ice walls.
- Burble Hekelot - Another former member of Phantom's Zan'ei Army. Burble is a frog-like boss who attacks (sometimes while hanging from the ceiling) with his tongue, launches missiles from his back, spits bubbles, and turns into a big ball to smash Zero.
- Kuwagust Anchus - A member of Harpuia's Rekku Army. As he was built with the same technology of Herculious Anchortus, they are known as brother Reploids. When the player faces him again in the final stage, Zero fights both him and Herculious together.
- Elpizo - Leader of the Resistance and the final boss of the game. He absorbs the Dark Elf and transforms into a terrifying menace.
Story Edit
One year has passed since Zero defeated Copy X. He has since spent his time wandering the desert defeating wave after wave of Pantheons. As the game opens, Zero wearily makes his way through a sand-storm wrapped in a tattered cloak. As the sands die down he realizes he is once more being chased by enemies. Despite being in disrepair, with cracked armor and broken weapons (his rod and shield are useless), his cloak is thrown to the winds and his Buster Shot is drawn in defense.
"This isn't fun anymore," he says, after dispatching the first of an endless wave of enemies.
Elsewhere, the three surviving members of the Four Guardians (Phantom self-destructed trying to stop Zero's assault on Area X) assumed command of Neo Arcadia, with Harpuia as the leader. Copy X's death was covered up, as the humans revered him as their savior.
Some time later, a barely-functioning Zero is brought to the newly-completed Resistance Base (strangely, by Harpuia), and Zero learns that the conflict between Neo Arcadia and the Resistance has still continued during his absence. While he was gone, Ciel was working on a way to solve the energy crisis that led to all of the problems with Neo Arcadia in the first place. However, the Resistance leader, a reploid named Elpizo, believing that Ciel's search was futile, leads a failed assault on Neo Arcadia, from which he is the only survivor. Driven mad by this, he declares his desire to harness the power of the legendary Dark Elf, which had brought about the Elf Wars a century ago.
Elpizo, using the powers granted by unsealing a portion of the power of the Dark Elf, invades Neo Arcadia and single-handedly breaks into the temple where the body of the real X, revered by all in the utopia, is kept. As it turned out, X had ended the Elf Wars by sealing the Dark Elf away with his body, thus leading to his disappearance. Despite the Guardians' and Zero's resistance, Elpizo succeeds in destroying X's body, which unseals the Dark Elf, and Elpizo begins to absorb its powers.
Zero manages to stop Elpizo from unleashing the Dark Elf on the world. As Elpizo lies on the floor dying, he apologizes for everything he's done. Amazingly, the Dark Elf saves him by turning him into a cyber elf and convincing Elpizo that she is not truly evil. As the two elves depart, Mega Man X himself arrives and tells Zero about the Dark Elf. She was originally made to be a savior, but was cursed by a man named Dr. Weil, and used...
...Meanwhile, in a mysterious area, a voice calls for someone named Omega to act.
Gameplay Edit
This game follows almost the exact same game-play rules as its predecessor. Once again, players take control of the Reploid known as Zero, and lead him through various levels in the battle against the forces of Neo Arcadia.
The controls are identical to that in the previous game, with players given the option to assign functions to the buttons they are most comfortable using. Once again, players are given a variety of weapons that include the Z-Saber, the Buster Shot, and the Shield Boomerang. Zero's skill levels with these weapons are minimal at first, but they will strengthen with repeated use.
The Triple Rod from the previous game, however, has been replaced with the Chain Rod. It can be used to pull enemies or objects closer, pull shields off enemies or if latched on to an immovable object, to swing over chasms.
Cyber Elves also make a reappearance and once again, they come in three types, Nurse, Animal and Hacker. Unlike the previous game, where all of the Sub-Tanks could only be obtained from using four special Nurse Cyber Elves, two Sub-Tanks are hidden in the game in two of the eight selectable stages.
Instead of selecting from a list of missions, the traditional Stage Select option found in the original Mega Man and the Mega Man X games makes a return, although the player can only select from four at a time. Unlike in the previous game, none of the stages are linked.
The second game introduces the concept of various forms, which can be earned by meeting certain criteria throughout the game, ranging from killing twenty enemies in a stage with a dashing slash technique to getting twenty-five energy capsules in one stage.
- Normal Form (Red) - Zero's basic form. The player starts the game with this. It has basic stats in all areas. No glaring weaknesses or strengths. It uses the standard 3-hit Z-Saber combo of "back, forward, overhead".
- Energy Form (Yellow) - This form makes energy crystals appear more often. The Buster Shot and Z-saber gets an attack boost, while sacrificing some speed. The player have to grab twenty-five energy capsules in mission to awaken this form.
- X Form (Blue) - The Buster Shot gains an attack boost, and also allows a rapid fire capability. Like the Erase form, it cannot perform Z-Saber combos and instead uses only the forward slash. It is named after X because of X's fighting-style (which relied heavily on the buster) in the Mega Man X series. Zero also uses the Z-Saber the way X uses it in Mega Man X6. The player need to kill fifty enemies in mission with the Buster Shot to awaken this form.
- Defense Form (Green) - Zero's defense is increased to its maximum, as well as sacrificing attack power in the process (except for the shield boomerang, which gains an attack boost). The player need to kill twenty enemies in mission with Shield Boomerang to awaken this form.
- Erase Form (Pink) - The Erase Form allows the Z-Saber and Shield Boomerang to nullify enemy shots. It cannot use saber combos, instead it always uses the forward slash. The player need to ricochet thirty shots back at enemies with the Shield Boomerang in mission to awaken this form.
- Active Form (Orange) - Zero's speed is increased to the maximum. The Z-Saber cannot perform combos, and will instead use only the back slash. However, this form enables Zero to perform rolling attacks with the saber while jumping or dashing. The rolling attacks, while not very powerful, can strike multiple times. The player need to kill twenty enemies in mission with the Z-Saber while dashing to awaken this form.
- Power Form (Purple) - Zero's power is boosted to its limit, while sacrificing some speed in the process. This form also negates the three-hit Z Saber combo in favor of a single overhead slash. The player should pull anything thirty times in mission with the Chain Rod in order to awaken this form.
- Rise Form (Grey) - More or less identical to the Normal form, but the 3rd (overhead) slash in the Z-saber combo is replaced by the rising slash, which is a little faster, and is given an attack boost. The player need to kill twenty enemies in mission with the jumping slash to awaken this form.
- Proto Form (Black) - Zero gains an attack increase to all weapons, but besides the Shield Boomerang none of them can be charged, and the Z-Saber cannot perform combos. It will use only the back slash. Zero also takes twice the normal damage from enemy attacks. Unlike the other Hard modes in the Zero games, Zero 2 makes the player use only the Proto Form, limiting all weapons to their base attacks. The one thing that deviates is that the Charge Shot(s) is absent in it, as all other Hard Modes have it. Unlike the Galacta Armor from the fourth game, it doesn't deal 2x damage.
- Ultimate Form (Glowing Crimson) - This form gives all of Zero's weapons an increase in power, as well as raising his speed and defense. This form also allows the player to input simplistic Street Fighter-esque commands to execute charged attacks instantly. This form also appears in the first, third and fourth game. The player need to level up and use every single cyber-elf in game and then complete the game in order to awaken this form (can be unlocked at the same time as the Proto Form).
EX SkillsEdit
Absent in the previous Mega Man Zero game are the EX Skills. They are abilities or techniques that can be earned from defeating a boss, which were a staple of the original Mega Man games. The only catch is that to earn the EX Skills in Mega Man Zero 2, Zero must be at A or S Rank when he defeat the boss, as that is the only time when the bosses will use their EX Skills.
As in Mega Man Zero, the rank is dependent on how well the player finish a particular stage with points being awarded for not taking damage, for defeating enemies and for being quick and for not using Cyber Elves.
Just like in the first game, a "New Game Plus" can be played by beating the game and loading the completed save file. In the new game, Zero will start with all activated Cyber Elves used from the previous game still in effect (the penalties, however, will still remain). Zero will also get to keep any EX Skills and alternate forms that he earned in the previous game as well.
Additional modes can also be unlocked under proper conditions.
Hard Mode is unlocked by beating the game once. Players need to hold L when selecting to start a New Game. In Hard Mode, Zero is in his "Proto Form", which doubles his attack strength but halves his defense. In addition, Zero's weapons cannot increase in strength and he cannot earn any EX skills or alternate forms.
Beating Hard Mode will unlock a special "Image Gallery" option. The player need to hold L and Select when selecting New Game to enter it.
Unlike the other games in the series, there is no Ultimate Mode to be unlocked. However, an "Ultimate Form" can be unlocked by leveling and using every Cyber Elf in the game. It increases all of Zero's stats and also allows him to use full-charge attacks instantly by means of simplistic button combos.
Two Player ModeEdit
If players have two cartridges and a link cable, it is possible to link two G.B.A.s and take part in a two player game. There are three modes available to take part in:
- Time Attack - Set a goal somewhere in the stage. After three tries, the player with the shortest time to the goal wins.
- Enemy Battle - Defeat the most enemies from the generator within the time limit.
- Get Item - Collect the most items from the map within the time limit.


text:
As media critics continue to pick over the gradually decomposing carcass of the first half of this Nats season, more and more faults will be discovered. Former Postie and current MLB.com columnist Richard Justice offered a few more during a recent conversation with Sports On Earth's Will Leitch. (Audio here.)
This started when Leitch suggested that the Nats were among baseball's most disappointing teams at the All-Star break, and that they were running out of time to turn things around.
"It feels that way," Justice agreed. "The pitching's been okay, despite everything. Strasburg gets a lot of headlines, but he's been okay. It's amazing the decline in offense. And I think expectations are part of it.
"That's one of the things I like about the Tigers, and I like about the Cincinnati Reds," Justice continued. "They have tough fans, they're expected to win every year, and they don't cry and whine and blame others when they lose a game. The Nationals have gotten to be whiny this year. It's like, oh, the media did this….
"They added a leadoff hitter, a center fielder, in Span. They deepened the bullpen. I mean, they were a good team. I thought Dan Haren was a good signing, because I thought he made that middle-age adjustment. But you know, you're right, if LaRoche doesn't get it going, if Harper doesn't go crazy and Span [too], they have too many small problems that you can't fix it. You're talking about making a big trade for a bat or a starter or something. Maybe the kid Anthony Rendon will take them.
"But Tom Boswell of The Washington Post wrote a couple days ago, they don't need a trade, they need a psychiatrist. And I think it pissed the players off. And maybe they need it. You know what, I thought about this — Davey Johnson's a friend of mine, but maybe they need somebody to come in and put a foot on their butt. Because they've got a chip on their shoulder, but that chip is not translating to the field. And it's so many little things, you can't look to one thing.
"But they do have pitching and I think their bullpens' going to be okay, so they've got a chance. And certainly when you look at Atlanta, you don't say well we're afraid of that team. Because unless the Uptons and Hayward get going, they've got some issues too."
If Boz's column made them mad, maybe we need to write stuff to make them happy, because mad doesn't seem to have worked very well.
(Via Eric Fingerhut, who continues to write interesting things about our sports coverage here.)


text:
EDDINGTON | Jessica Frick, a 21-year-old John Bapst High School graduate who had traveled to Haiti for two weeks, has returned home after getting caught in the chaos that followed the …
Comments for: Eddington woman back home, tells of chaos in Haiti
Posted Jan. 17, 2010, at 10:55 a.m.
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text: MrLogic - Unregistered November 24, 2010 9:00 AM If VJ wants to move his team up the grid (and I'm sure he does) he could simply achieve this by off-loading both Sutil and Liuzzi. New driver line up - Di Resta and Hulkenberg. Now that would be worth watching.. otherwise it will be just another snorefest at FIF1 for 2011. 3 agree 0 disagree


text:
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Rent Case Studies in Immunology 5th edition today, or search our site for other textbooks by Raif Geha. Every textbook comes with a 21-day "Any Reason" guarantee. Published by Garland Science.
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text:
Gholu Fish In Curds
Brief Description
Gholu Fish in Curds is spicy and tasty dish. It lets your mouth full of water. Gholu Fish is best at its taste when it is served with plain steamed rice.
|Preparation Time
|15 minutes
|Cooking Time
|15 minutes
Ingredients For Gholu Fish In Curds
- Gholu Fish - 3/4 kg ( Big pieces)
- Peeled potatoes - 4
- Red dry chilies – 4- 5
- Flakes of garlic - 4
- Ginger - ½"
- Coriander seeds - 1 tablespoon ( dry)
- Cumin seeds - 1/2 teaspoon
- Finely chopped onion - 1
- Cardamoms - 6
- Cloves - 4
- Bay leaf - 1
- Curds - 1 1/2 cup
- Oil - 2 1/2 tablespoon
- Oil - 1 tablespoon
- Salt as needed
How To Make Gholu Fish In Curds
- Take a large bowl. Mix garlic, coriander, ginger, cumin seeds, and red chilies. Grind them properly.
- For more fragrance roast the cumin and coriander seeds before blending them.
- Clean the pieces of potato with water.
- Make small holes in each piece of potato using fork.
- Take a sauce pan. Heat little oil in it. Place potato pieces into it and fry them until golden brown in color. Set aside for some time.
- Now put chopped onions into the same oil, and cook them until onions become tender.
- Add small lumps of garlic, coriander, ginger, cumin seeds, and chilies to the above mixture.
- Fry this mixture till oil starts floating on top of the mixture.
- Mix for some time and then pour about 1 1/2 cups of hot water into the above mixture.
- Make sure that the potato becomes tender and gravy becomes thickens.
- If required, add more little water to it.
- Now add pieces of fish and salt as needed.
- Reduce the heat and cook over low flame.
- Now beat the curd. The curd should be sour a little bit.
- Take a skillet and add 1 tbsp of refined oil in it and heat it.
- Mix in bay leaves, cloves, and cardamoms. Now pour this mixture over the beaten curds.
- Add this curd mixture into the gravy of fish and let it cook over low flame for few mins.
- Turn off the flame. Shift the fish gravy to a serving plate.
- Garnish this Fish gravy with finely chopped coriander leaves & green chili.
- Serve it with plain and steamed rice.
Other Similar Recipes
- Geflite fish
- Fish molee
- Fish tacos


text:
Internal aluminium partitions
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Potter Interior Systems' internal aluminium partitions systems are designed with flexibility in mind to allow for various configurations. With new, innovative design features including a +/-25mm deflection head track, Potter Interior Systems' aluminium systems have several key points of difference.
Potters A Series 132 partition suite offers system rigidity in both solid and glazed partition walls and can easily be integrated with other Potter Interior Systems partition suites such as the C Series 45, where slimming down of profiles is required or preferred.
A vast range of surface finishes and colour options are available, including both anodising and powdercoating, which allow the designer or builder to create the desired interior environment and coordinate with other interior colours.
Internally glazed partitions, as used in the Manukau Tertiary Centre, allow natural light to transmit through the building which can decrease the amount of energy required for powered lighting. With manifestations fitted to the glazing, these partitions provide privacy without blocking out the light.
USG Boral 92mm steel stud – made here in New Zealand from New Zealand steel – provides the necessary rigidity for the Manukau Tertiary Centre internal solid partition walls.
Potters' continuous custom-made light boxes provide the right solution for the Manukau Tertiary Centre in areas surrounding the large open area of central space, which integrated perfectly with the perforated ceiling linings.
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Presidential candidates flocked to the Granite State during the July Fourth weekend.
Former New York Gov. George Pataki and Louisiana Gov. Bobby Jindal attended a cookout hosted by the Merrimack County Republican Committee. The event was low-key and gave both Republican candidates the chance to talk one on one with voters.
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"I am disappointed he (Trump) hasn't seen that it was a stupid and wrong comment," Pataki said. "I have and...
Read the Full article at WMUR here.


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Emerging therapies for severe asthma
Many patients with asthma have poorly controlled symptoms, and particularly for those with severe disease, there is a clear need for improved treatments. Two recent therapies licensed for use in asthma are omalizumab, a humanized monoclonal antibody that binds circulating IgE antibody, and bronchial thermoplasty, which involves the delivery of radio frequency energy to the airways to reduce airway smooth muscle mass. In addition, there are new therapies under development for asthma that have good potential to reach the clinic in the next five years. These include biological agents targeting pro-inflammatory cytokines such as interleukin-5 and interleukin-13, inhaled ultra long-acting β2-agonists and once daily inhaled corticosteroids. In addition, drugs that block components of the arachidonic acid pathway that targets neutrophilic asthma and CRTH2 receptor antagonists that inhibit the proinflammatory actions of prostaglandin D2 may become available. We review the recent progress made in developing viable therapies for severe asthma and briefly discuss the idea that development of novel therapies for asthma is likely to increasingly involve the assessment of genotypic and/or phenotypic factors.
Asthma is a chronic inflammatory disease of the airways that affects over 300 million individuals worldwide
Figure 1
Potential targets for selected novel therapies for treatment resistant asthma
Potential targets for selected novel therapies for treatment resistant asthma. The figure summarizes targets for a selection of therapies that are recently licensed or under clinical development for patients with severe treatment resistant asthma. Abbreviations: CRTH2, chemoattractant receptor-homologous molecule expressed on Th2 cells; FLAP, lipoxygenase-activating protein; IL-, interleukin-; PPAR, proliferator-activated receptor; PDE, phosphodiesterase; PGD2, prostaglandin D2.
Biological agents
The first and as yet only biological agent licensed for the treatment of asthma is omalizumab, a humanized monoclonal antibody that binds circulating IgE antibody, preventing it from binding to its specific high-affinity receptor on mast cells and basophils
A number of biological agents have been developed to target cytokines thought to play an important role in asthma pathogenesis
Two recent exploratory studies have examined anti-IL5 monoclonal antibody (mepolizumab) treatment in patients with severe asthma
Figure 2
Cumulative number of severe exacerbations in each study group over the course of 50 weeks treatment with mepolizumab or placebo
Cumulative number of severe exacerbations in each study group over the course of 50 weeks treatment with mepolizumab or placebo. Mean number of exacerbations per subject over the course of the 50-week treatment period was 2.0 in the mepolizumab group, compared with 3.4 in the placebo group (relative risk, 0.57; 95% confidence interval, 0.32 to 0.92;
A number of clinical trials employing monoclonal antibodies targeting IL-4 and/or IL-13 in asthma are underway
Daclizumab is a humanized monoclonal antibody that binds specifically to the CD25 subunit of the high-affinity IL-2R, and inhibits IL-2 binding and T-cell activation. A pilot study of daclizumab in patients with moderate to severe asthma reported minor improvements in lung function and asthma control
Patients with asthma may be more susceptible to respiratory viruses due to impaired Th1 immunity
New inhaled long-acting bronchodilators and corticosteroids
In addition to the development of novel therapies, refinements in the pharmacological properties of drugs currently used to treat asthma, such as long-acting β2-agonists and inhaled corticosteroids is a major focus of the pharmaceutical industry. Inhaled ultra long-acting β2-agonists (ultra-LABAs) such as indacaterol, currently licensed for COPD, have a longer half-life than current LABAs and are suitable for once daily administration
Arachidonic acid pathway blockers
Pro-inflammatory cysteinyl leukotrienes (LTs) are synthesized from arachidonic acid by 5-lipoxygenase (LO) and 5-lipoxygenase-activating protein (FLAP) in inflammatory airway cells. In addition to inhibiting the production of the cysteinyl LTs, 5-LO and FLAP inhibitors such as GSK-2190915
Bronchial thermoplasty
Bronchial thermoplasty involves the delivery of radio frequency energy to the airways by flexible bronchoscopy with the aim of reducing airway smooth muscle mass and responsiveness in asthma
Figure 3
Total Asthma Quality of Life Questionnaire (AQLQ) score over 12 months after treatment with bronchial thermoplasty (BT) (diamonds) or sham control (squares) in the per protocol population
Total Asthma Quality of Life Questionnaire (AQLQ) score over 12 months after treatment with bronchial thermoplasty (BT) (diamonds) or sham control (squares) in the per protocol population. *Posterior probability of superiority = 97.9%. Reprinted with permission of the American Thoracic Society. Copyright © American Thoracic Society
Other anti-inflammatory drugs
A number of novel drugs under development may prove to have a role in the management of asthma. Phosphodiesterase (PDE)4 inhibitors have immunomodulatory effects over a number of inflammatory cells potentially relevant to the treatment of severe asthma
Several drugs licensed for treating other conditions may also have a role in the management of asthma. In a randomized controlled trial of 58 patients with severe asthma with fungal sensitization (SAFS)
Factors influencing the response to novel therapies
Genotypic and phenotypic factors can influence the response to drug treatment for asthma
Conclusions and future directions
Omalizumab, a humanized monoclonal antibody that binds circulating IgE antibody, and bronchial thermoplasty, where radio frequency energy is delivered to the airways to reduce airway smooth muscle mass are valuable additional therapies for the management of severe asthma. There is a need to identify new therapies that are effective and safe and target sub-phenotypes of asthma. Of therapies currently under development, biological agents directed at blocking pro-inflammatory cytokines such as interleukin-5 and interleukin-13, ultra long-acting β2-agonists and once daily inhaled corticosteroids as well as drugs blocking components of the arachidonic acid pathway such as FLAP inhibitors and CRTH2 receptor antagonists have the greatest potential to reach the clinic. In the future, both genotypic and phenotypic factors are likely to guide the choice of intervention in each individual with severe asthma.
List of abbreviations
AIR trial: Asthma Intervention Research trial; AQLQ: asthma quality of life questionnaire; CRTH2: chemoattractant receptor-homologous molecule expressed on Th2 cells; FDA: U.S. Food & Drug Administration; FLAP: lipoxygenase-activating protein; IL-: interleukin; LAMAs: long-acting antimuscarinic agents; LO: lipoxygenase; LTs: leukotrienes; MAPK: mitogen-activated protein kinase; PPAR: proliferator-activated receptor; PDE: phosphodiesterase; PGD2: prostaglandin D2; SAFS: severe asthma with fungal sensitization; TNF: tumor necrosis factor; Ultra-LABAs: ultra long-acting β2-agonists.
Competing interests
NCT received industry-sponsored grant funding from Aerovance, Asthmatx, Glaxo Smithkline, MedImmune Ltd, Novartis, Centocor and Synairgen for participating in clinical trials.
Authors' contributions
NCT conceived the article and prepared the initial draft of the manuscript. All authors drafted further versions of the manuscript and approved the final version.
GINA Report, Global Strategy for Asthma Management and Prevention
Expert Panel Report 3 (EPR-3): Guidelines for the Diagnosis and Management of Asthma-Summary Report 2007
Attitudes and actions of asthma patients on regular maintenance therapy: the INSPIRE study
The limitations of severe asthma: the results of a European survey
Challenges of treating asthma in people who smoke
Role of symptoms and lung function in determining asthma control in smokers with asthma
Refractory asthma in the UK: cross-sectional findings from a UK multicentre registry
Diagnosis and definition of severe refractory asthma: an international consensus statement from the Innovative Medicine Initiative (IMI)
The mechanisms, diagnosis, and management of severe asthma in adults
New targets for drug development in asthma
New therapies for asthma: is there any progress?
The rationale for treating allergic asthma with anti-IgE
Anti-IgE for chronic asthma in adults and children
Efficacy and Safety of Subcutaneous Omalizumab vs Placebo as Add-on Therapy to Corticosteroids for Children and Adults With Asthma
Future forms of immunotherapy
Safety and tolerability of omalizumab
Baseline characteristics of patients enrolled in EXCELS: a cohort study
Omalizumab: potential risk of arterial thrombotic events
A new look at the pathogenesis of asthma
Narrative review: the role of Th2 immune pathway modulation in the treatment of severe asthma and its phenotypes
Tumour necrosis factor (TNF{alpha}) as a novel therapeutic target in symptomatic corticosteroid dependent asthma
Inhibition of Tumor Necrosis Factor α for Refractory Asthma
A Randomized, Double-blind, Placebo-controlled Study of Tumor Necrosis Factor-{alpha} Blockade in Severe Persistent Asthma
Efficacy and safety of etanercept in moderate-to-severe asthma: a randomised, controlled trial
Mepolizumab for Prednisone-Dependent Asthma with Sputum Eosinophilia
Mepolizumab and Exacerbations of Refractory Eosinophilic Asthma
Eosinophils in Asthma-Closing the Loop or Opening the Door?
The Prevalence of Nonadherence in Difficult Asthma
Cytokine inhibition in severe asthma: Current knowledge and future directions
IL-13 in Asthma: The Successful Integration of Lessons from Mice and Humans
The Effects of IL-13 Blockade on Allergen-Induced Airway Responses in Mild Atopic Asthma
Effect of an interleukin-4 variant on late phase asthmatic response to allergen challenge in asthmatic patients: results of two phase 2a studies
Daclizumab Improves Asthma Control in Patients with Moderate to Severe Persistent Asthma: A Randomized, Controlled Trial
Rhinovirus induced lower respiratory illness is increased in asthma and related to virus load and Th1/2 cytokine and IL-10 production
Novel bronchodilators in asthma
Novel long-acting bronchodilators for COPD and asthma
The role of cigarette smoking on persistent airflow obstruction in asthma
Additive role of tiotropium in severe asthmatics and Arg16Gly in ADRB2 as a potential marker to predict response
Targeting inflammation using selective glucocorticoid receptor modulators
Dissociation of transactivation from transrepression by a selective glucocorticoid receptor agonist leads to separation of therapeutic effects from side effects
Characterization of ZK 245186, a novel, selective glucocorticoid receptor agonist for the topical treatment of inflammatory skin diseases
BOL-303242-X, a novel selective glucocorticoid receptor agonist, with full anti-inflammatory properties in human ocular cells
What's all the FLAP about?: 5-lipoxygenase-activating protein inhibitors for inflammatory diseases
Mast Cell Phenotype, Location, and Activation in Severe Asthma: Data from the Severe Asthma Research Program
CRTH2 and D-Type Prostanoid Receptor Antagonists as Novel Therapeutic Agents for Inflammatory Diseases
Radiofrequency ablation of airway smooth muscle for sustained treatment of asthma: preliminary investigations
Reduction in airway hyperresponsiveness to methacholine by the application of RF energy in dogs
In vivo evaluation of the effectiveness of bronchial thermoplasty with computed tomography
Effect of bronchial thermoplasty on airway distensibility
Bronchial Thermoplasty for Asthma
Asthma Control during the Year after Bronchial Thermoplasty
Safety and Efficacy of Bronchial Thermoplasty in Symptomatic, Severe Asthma
Effectiveness and Safety of Bronchial Thermoplasty in the Treatment of Severe Asthma: A Multicenter, Randomized, Double-Blind, Sham-Controlled Clinical Trial
Long term (5 Year) safety of bronchial thermoplasty: Asthma Intervention Research (AIR) trial
Phosphodiesterase-4 inhibitors for asthma and chronic obstructive pulmonary disease
Efficacy and safety of roflumilast in the treatment of asthma
Comparison of roflumilast, an oral anti-inflammatory, with beclomethasone dipropionate in the treatment of persistent asthma
Pharmacology of a potent and selective inhibitor of PDE4 for inhaled administration
The inhaled phosphodiesterase 4 inhibitor GSK256066 reduces allergen challenge responses in asthma
Kinase inhibitors: a new approach to rheumatoid arthritis treatment
"Go upstream, young man": lessons learned from the p38 saga
Effect of p38 MAPK inhibition on corticosteroid suppression of cytokine release in severe asthma
The link between fungi and severe asthma: a summary of the evidence
Randomized Controlled Trial of Oral Antifungal Treatment for Severe Asthma with Fungal Sensitization: The Fungal Asthma Sensitization Trial (FAST) Study
Profound adrenal suppression secondary to treatment with low dose inhaled steroids and itraconazole in allergic bronchopulmonary aspergillosis in cystic fibrosis
Iatrogenic adrenal insufficiency as a side-effect of combined treatment of itraconazole and budesonide
Peroxisome proliferator-activated receptor-gamma agonists as potential anti-inflammatory agents in asthma and chronic obstructive pulmonary disease
Bronchodilatory Effect of the PPAR-[gamma] Agonist Rosiglitazone in Smokers With Asthma
Potential therapeutic role for statins in respiratory disease
Anti-inflammatory mechanism of simvastatin in mouse allergic asthma model
Inhibition of antigen-induced bronchial smooth muscle hyperresponsiveness by lovastatin in mice
Pravastatin attenuates allergic airway inflammation by suppressing antigen sensitisation, interleukin 17 production and antigen presentation in the lung
Lovastatin inhibits bronchial hyperresponsiveness by reducing RhoA signaling in rat allergic asthma
A Novel Anti-Inflammatory Role of Simvastatin in a Murine Model of Allergic Asthma
Simvastatin Inhibits Airway Hyperreactivity: Implications for the Mevalonate Pathway and Beyond
Simvastatin does not exhibit therapeutic anti-inflammatory effects in asthma
Effects of atorvastatin added to inhaled corticosteroids on lung function and sputum cell counts in atopic asthma
Simvastatin in the treatment of asthma: lack of steroid-sparing effect
Effects of short-term treatment with atorvastatin in smokers with asthma-a randomized controlled trial
Augmented epithelial endothelin-1 expression in refractory asthma
Endothelin-1 induces hypertrophy and inhibits apoptosis in human airway smooth muscle cells
Asthma: defining of the persistent adult phenotypes
Pharmacogenetic association between ALOX5 promoter genotype and the response to anti-asthma treatment
Influence of Leukotriene Pathway Polymorphisms on Response to Montelukast in Asthma
Pharmacogenetics of the 5-lipoxygenase biosynthetic pathway and variable clinical response to montelukast
Noneosinophilic asthma: A distinct clinical and pathologic phenotype
Inflammatory subtypes in asthma: Assessment and identification using induced sputum
Non-eosinophilic corticosteroid unresponsive asthma
Non-invasive markers of airway inflammation as predictors of oral steroid responsiveness in asthma
Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial
Low Sputum Eosinophils Predict the Lack of Response to Beclomethasone in Symptomatic Asthmatic Patients
Pathological features and inhaled corticosteroid response of eosinophilic and non-eosinophilic asthma
Clarithromycin Targets Neutrophilic Airway Inflammation in Refractory Asthma
T-helper Type 2-driven Inflammation Defines Major Subphenotypes of Asthma
Pre-publication history
The pre-publication history for this paper can be accessed here:


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|"Tobias Bocanegra (JIRA)" <j...@apache.org>
|[jira] Commented: (JCR-2233) JSR-283: mix:created/mix:lastModified - auto-set but allow modification for imports
|Wed, 29 Jul 2009 11:52:14 GMT
[ https://issues.apache.org/jira/browse/JCR-2233?page=com.atlassian.jira.plugin.system.issuetabpanels:comment-tabpanel&focusedCommentId=12736575#action_12736575 ] Tobias Bocanegra commented on JCR-2233: --------------------------------------- regarding a) no, the jcr:created was defined protected before and should stay this way. session or workspace imports already respect this and (re)set the values correctly. regarding b) this is already the case, i.e. not protected regarding c) as a simple implementation, i suggest to update the jcr:lastModified(By) properties if a significant modification is performed on the node (but not it's sub tree) and the property was not modified transiently. it is to define what is considered as a significant modification. most probably: - add/remove child node (includes move/copy underneath) - add/remove/update properties - add/remove mixins, change primary type most probably not: - versioning operations - locking operations - move (the node itself) - copy (the node itself) > JSR-283: mix:created/mix:lastModified - auto-set but allow modification for imports > ----------------------------------------------------------------------------------- > > Key: JCR-2233 > URL: https://issues.apache.org/jira/browse/JCR-2233 > Project: Jackrabbit Content Repository > Issue Type: Improvement > Components: jackrabbit-core, JCR 2.0 > Reporter: Alexander Klimetschek > Priority: Minor > Fix For: 2.0.0 > > > Following the discussion in JCR-2116, I propose it would be a good idea to have jcr:created, jcr:createdBy (from mix:created) and jcr:lastModified, jcr:lastModifiedBy (mix:lastModified) not protected, but still automatically set those properties in case they were not modified by the client. > Three advantages: > a) This allows for importing content with these properties, where eg. the jcr:created should point to the original creation date of the content, not when it was imported. > b) Same for jcr:lastModified, which often must be set manually for ensuring correct behaviour when doing synchronizations etc. > c) In order to take advantage of the automatically-set behaviour mentioned in the spec, it would be nice if the repository would set them in the case the client is not writing those properties. This way you can ensure the properties are correctly set when you cannot control all client-code modifying the content (eg. webdav). > Question: would this be in line with the spec? I would say, yes, since we say we don't implement "protected", which is allowed, but add a hybrid approach (which is not explicitly forbidden, IIUC). > For the reference, here is the definition from the latest JSR-283 doc: > [mix:lastModified] mixin > - jcr:lastModified (DATE) autocreated protected? OPV? > - jcr:lastModifiedBy (STRING) autocreated protected? OPV? > [mix:created] mixin > - jcr:created (DATE) autocreated protected? OPV? > - jcr:createdBy (STRING) autocreated protected? OPV? > And here is the current cnd definition in JR 2.0: > http://svn.apache.org/viewvc/jackrabbit/trunk/jackrabbit-core/src/main/resources/org/apache/jackrabbit/core/nodetype/builtin_nodetypes.cnd?view=co -- This message is automatically generated by JIRA. - You can reply to this email to add a comment to the issue online.
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Manfrotto 190XPRO3 Horizontal Column Aluminum Tripod
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Read online The Horse Dictionary: English-Language Terms Used in Equine Care, Feeding, Training, Treatment, Racing and Show Download PDF EPUB ebook44
Download or read The Horse Dictionary: English-Language Terms Used in Equine Care, Feeding, Training, Treatment, Racing and Show
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With Kanye and Ron Burgundy, Have Boston Colleges Officially Lost Their Minds?
DreamWorks via Everett Collection
Something weird is going on with the colleges up in Boston. This week, two respected institutions of higher education, Emerson College and Harvard University, announced that they were partnering up with celebrities for special events. While it's not unusual for public figures to take an interest in furthering their education, or even for colleges to recruit famous faces for publicity, the choices that Emerson and Harvard made were so unusual, it almost makes us worry that Boston universities may be losing their minds.
As part of their increasingly odd promotional campaign, the team behind Anchorman 2 has struck a deal with the Emerson College School of Communication to rename the school after Ron Burgundy for the day on December 4. It's the latest in a line of publicity stunts than include a series of commercials for Dodge Durango and an exhibit at the Newseum in Washington DC that chronicles Burgundy's storied career in the news. As part of the deal with Emerson College, Will Ferrell himself will appear on campus to take part in a press conference where he will regale students and fans with tales about his rise to the top and advice on becoming a great anchor person themselves. He will also introduce an exclusive screening of the sequel.
No matter how entertaining you find Ferrell's polyester-suit-wearing, carefully coifed alter ego, the weird collaboration got us thinking about some of the classes that Ron Burgundy would teach if he actually did open a School of Communication. We can only imagine it would include such courses as:
–The Care and Cultivation of Your Moustache – How are the people supposed to trust the news your reading if they can't see your intelligence, sophistication and manliness right there on your face?
–Scotch: An Appreciation – Proper news anchors only drink scotch. Drinking anything else signals that your are a lesser news reader, better suited to puff pieces about animals doing entertaining things.
–Women Can Be Anchormen Too, I Guess – Taught by Veronica Corningstone. Titled by Ron Burgundy.
–Choosing Your Signature Suit – Not everyone is blessed with a last name that's also a color. This class will teach you to overcome that obstacle and become the sharpest dresser of the 1970s, regardless of what decade it currently is. Only polyester and polyester blends are acceptable.
–Advanced Martial Arts – Less about technique, more about brute force. Also teaches you to improve your observation skills so that you can better spot random objects on the ground to bludgeon your rivals with. A follow-up course is offered, entitled Laying Low For When You Might Have Killed A Guy With a Trident.
But lest Emerson steal the spotlight, Harvard had a celebrity collaboration of their own make the news today. Over the weekend, Kanye West stopped by the Harvard School of Design to give a lecture as part of a series of talks with this design and production company, DONDA. During his speech, West talked about how he believes that "the world can be saved through design" and that "Utopia is actually possible, but we're led by the least noble, the least dignified, the least tasteful, the dumbest, and the most political." West also encouraged the students present to continue to hone their craft and to continue to innovate and create, before gifting them with tickets to his concert that night, although he did note that he felt self-conscious showing a roomful of architects his stage designs. By his side was his fiancée Kim Kardashian and DONDA's creative director, Virgil Abloh, both of whom Instagrammed photos from the event.
Of course, anything that Ron Burgundy can do, West will claim that he can do better, and so, with that in mind, we've also come up with a few ideas of what West's idea of an aesthetically pleasing Utopia might include.
-The only music that will be played on the radio or sold in stores has been released by, produced by, or featuring Kanye West. Any music that deviates from these guidelines need to be submitted for approval by West himself.
-Leather sweatpants will be the customary attire for not only exercise, but formal events as well.
-An amendment will be added to the United States Constitution that clarifies, once and for all, that Beyonce's "Single Ladies" video is the greatest video of all time. Anyone stating otherwise will be forced to watch it repeatedly until they understand its genius.
-Any gathering of people that wishes to call itself a "conference" must first ensure that there is a marble conference table present. Conferences will be considered extra-tasteful if the rugs include cherub imagery.
Interestingly enough, West will make a cameo appearance in Anchorman 2 when it is released on December 20. In the meantime, he is currently on tour promoting his album, Yeezus.