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In our beautifully soft premium jersey, this collared top is a sophisticated, flattering wardrobe staple that you can dress up in an instant for elegant evening looks. The keyhole neck fastening is a simple but chic little detail you'll love.
Our Story
Our vision is to be the number one globally recognised British brand authority for cashmere. It is after all, at the heart of everything we do. What started as a collection of just 25 pieces has grown internationally with boutiques opening across the UK. Join our journey and discover our story...Find out more


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This property has been sold.Search for Available Property.
29.02 acres in Sabine County, Texas
Searching for the ultimate escape from the city? This 29 acre tract of unrestricted, wooded waterfront offers the ultimate in privacy and unspoiled splendor for the hermit in you! Located in the center of a hunting and fishing paradise this land wraps completely around your own private cove! Enjoy camping, fishing and swimming now and build later!
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Water/Lake Front
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text: life in fairy tail would be awsome i think that if i was a fairy tail wizad i would want to be a fire, Celestrail spirit, or a god dragon slayer. But i also ant wait till halloween I am cosplaying as lucy heartfilia. And oyu may ask well which outfit well the outfit in the picture. Im so excited because my bff is going to be erza we still are tryig to figure out who will be gray and natsu though. Any ideas on anything write it down in the comments or my chat page. -jb22 <3


text: Sorting type: Most visited Most visited Alphabetical | This category contains pages related to the region of Orre. Pages in category "Orre" " Orre (オーレ Ōre) is a region that is the main setting of the games Pokémon Colosseum and Pokémon... Orre " The Purification Chamber is used in Pokémon XD: Gale of Darkness to purify Shadow Pokémon. The Purification Chamber Subcategories Characters from Orre Orre locations Retrieved from "http://pokemon.wikia.com/wiki/Category:Orre?oldid=364114" Ad blocker interference detected! Wikia is a free-to-use site that makes money from advertising. We have a modified experience for viewers using ad blockers Wikia is not accessible if you've made further modifications. Remove the custom ad blocker rule(s) and the page will load as expected. Categories: Regions


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Hotel Valley View
Call us 1800-300-2400-1 (Toll Free) and Get additional Discount upto 50% for this Hotel.
You are getting lowest possible rate for this hotel
- About Hotel
- Reviews
Room Description
Room Amenities
Room Inclusions
- Breakfast
- Air conditioning
- Cable/satellite television channels,
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- maker
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- Direct-dial phone
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- Minibar,Shower/tub combination
- Wireless Internet access
About Hotel Valley View
The Valley View Resort in Kullu is in the lap of nature in the majestic Himalayas, giving you every opportunity for an invigorating retreat from the city life and a relaxing stay in the mountains. The sweet smells of plum and apple orchards surround you, and the gurgling of the beautiful river Beas can be heard from the resort. The facilities at the resort are modern and efficient, and coupled with warm hospitality Valley View Resort provides both the leisure and business traveller with all that they might require for the ultimate mountain experience.
Checkin Time: 1200 pm
Checkout Time: 1200 pm
Hotel Amenities
- Doctor On Call
- Laundry Facilities
- Outdoor Games


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Steve Carell has praised the casting of James Spader as his replacement on The Office.
Spader was confirmed earlier this month to play "high-class Jedi warrior-like" CEO Robert California on the upcoming eighth season of the NBC comedy.
Crazy, Stupid Love star Carell told Access Hollywood that he is excited about the changes that Spader will bring to The Office and was delighted upon hearing that the former Boston Legal actor had taken over his spot.
Carell said: "I think it's an excellent choice. I think it's great and he will infuse all this new energy into the show."
"In talking to the cast, everyone's very excited and I know it'll be a good season."
Catherine Tate was previously tipped for the role following Carell's recent departure.
Spader appeared in The Office's season seven finale as an applicant for Michael Scott's (Carell) open manager position at Dunder Mifflin alongside Tate.
The eighth season of The Office will premiere on Thursday, September 22 at 9/8c on NBC.


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Marketecture Named a Finalist in the 2011 Red Herring Top 100 North America Awards
Growing Utah website builder and hosting company ranks among the elite in private ventures across America while providing SMBs the opportunity to go online.
"This year was very rewarding," said Alex Vieux, publisher and CEO of Red Herring. "The global economic situation has abated and there are many great companies producing really innovative and amazing products. We had a very difficult time narrowing the pool and selecting the finalists. Marketecture shows great promise and therefore deserves to be among the Finalists. Now we're faced with the difficult task of selecting the Top 100 winners of Red Herring North America. We know that the 2011 crop will grow into some amazing companies that are sure to make an impact."
The Red Herring editorial team selected the most innovative companies from a pool of hundreds from across North America. The nominees are evaluated on both quantitative and qualitative criteria, such as financial performance, technology innovation, quality of management, execution of strategy, and integration into their respective industries.
"We're excited to be selected as a Red Herring finalist," said Ari Monkarsh, Marketecture CRO and co-founder. "It recognizes our product innovation and our commitment to help small businesses achieve online business success." More information available at http://marketecture.com/
Being named a Red Herring Finalist is the most recent recognition for Marketecture, Inc. Previous 2010 milestones included ranking in the Inc. 5000 list of America's fastest-growing entrepreneurial businesses, receiving the Stevie Award for Sales & Customer Service, and ranking as one of Utah's fastest growing companies.
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About Marketecture:
Marketecture is the only company to combine the essential business tools that every SMB needs for online success; e-mail marketing, drag and drop content management, inventory tracking, lead management/CRM, social marketing, basic and advanced education.
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Ms. Andrea S.
Boston, Massachusetts - USA
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About Ms. Andrea S.
Registered Nurse senior student. Member of Nursing Honor Society Sigma Theta Tau, Golden Key International Honor Society and Alpha Lamda Delta Honor Society.
3 years Merit based scholarship recipient. 2 years student enrollment leader. Clinical experience in Beth Israel Deaconess Medical Center, Brigham and Womens, Children's Hospital, St. Elizabeth's and Cambridge Hospital.
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"Why, sometimes I've believed as many as six impossible things before breakfast." — The White Queen, "Alice in Wonderland"
The more President Obama talks about the supposed joys of his Affordable Health Care law, the more he resembles a political Mad Hatter, devoid of reason and ignorant of facts.
At a Rose Garden event Monday, the president's theatrics were on full display. With a chorus of supporters behind him, Obama blamed the "slow, wonky" rollout of health insurance enrollment on too many people trying to log on to the government's new marketplace website at the same time.
He labeled the false start "glitches." This isn't a glitch; it's a disaster.
The administration is asking for a lifeline from the private sector to offer technical help. Ponder this for a moment: The very people who claim they are sufficiently competent to run health care, which constitutes about one-sixth of the nation's economy, can't manage to launch a workable website, even though they had at least three years to set it up.
Keep in mind this is the same government that is having trouble making Medicare and Social Security permanently solvent.
The Obama administration has spent $200 million on its flawed marketplace system to sign up (so far) untold "thousands" — the president said thousands — not the 7 million, out of 40 million uninsured, he and other top officials predicted. He now wants to spend even more to hire people who actually know what they are doing. Why didn't the administration consult Silicon Valley first?
Let's put it in a way everyone can understand. You buy a can of sardines at the supermarket only to discover when you get home that the tin has been recalled because its contents are tainted and may make you sick. You return the sardines to the store, but instead of simply exchanging the tainted ones for untainted ones, the manager wants to charge you again for an untainted tin. Would that be fair? Would it be legal? Don't think so.
From the beginning, Obamacare was a tainted tin of sardines. It can't live up to its promises. It can't deliver health insurance we are used to at affordable prices. People are being laid off, not hired, reduced to part-time employment. They cannot shoulder the burden of purchasing overpriced, mismanaged health care. They'd like to exchange Obamacare for something that works, but the administration won't take back the tainted fish. And now we all will have to pay, and pay...
"I can't go back to yesterday," said Alice. "I was a different person then." Weren't we all, Alice; weren't we all.
Cal Thomas is a syndicated columnist in Washington.


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Click HERE for Dining Review in Lincoln
It would be very simple to just look at player's rating and rank accordingly. But we are also factoring in variables such as: need, hype, and location.
Now it's publisher Josh Harvey's turn to rank the class.
Randy Gregory
Arizona Western JC
|You don't even need a few minutes when watching Randy Gregory's highlight film to realize the Huskers are getting a talented player off the edge, with speed that will even give Big Ten offensive tackles trouble. What makes the prospect promising isn't just his ability to get to the quarterback. He's also very solid on run defense, showing the abilty to plug a hole at the line of scrimmage or get to the opposite sideline. Throw in the facts Nebraska needs a defensive end in 2013 and that Gregory has three years to play and he's your top incoming player.
Matt Finnin
College of Dupage (JC)
|Despite being 6-foot-7 and over 300 pounds, Finnin moves very well and is often seen downfield trying to open things up on long run plays. The offensive lineman has bounced around a lot in the last few years, so hopefully some stability will help his development. With likely three years to play, Finnin could end up playing a lot of snaps for Nebraska during his career. He's not a guy I expect to start right away in 2013, but don't be surprised to see him in the lineup later in the year.
D.J. Singleton
St. Peters Prep (NJ)
|Singleton wasn't just a good safety coming out of high school, he was an All-American and a four-star prospect. With his size and physcality, it's not of the question he could play a hybrid-linebacker at some point in his career. He was labeled a better run stopper out of high school than a defender of the pass, but he's more than serviceable downfield. Players like Braylon Heard and Charles Jackson have made the transition from a year off work, and we expect Singleton to do the same.
Terrell Newby
Chaminade (CA)
|Nebraska fans gush over sophomore wide receiver Jamal Turner's ability to make plays with the ball in his hands – Newby is even a bigger home run threat. He's not going to carry a defensive end and linebacker downfield on his back, but he's not afraid of contact and has the speed to run away from anyone. The Husker coaching staff will find a way to get him on the field next year.
A.J. Natter
Milton HS (WI)
|Natter has the frame to add a lot of weight at the next level and appears very serious about playing next season – increasing his weight, bench, and speed this offseason. Considering the Huskers picked the senior out of Wisconsin's backyard only makes the commitment better. Natter has an intensity when he plays and should be a true strongside defensive end. Don't be surprised if he gets reps in 2013.
Josh Banderas
Lincoln SW HS (NE)
|An All-American linebacker, there was never much doubt Banderas would sign with Nebraska, but just imagine if the Huskers would have lost him somehow? The LSW product probably had the intangibles to play for the Huskers this season and expect him in the mix in 2013. Banderas will become a fan favorite when Nebraska plays wide open offenses, because has the ability to play the entire field.
Maliek Collins
Center HS (MO)
|Unlike the junior college prospects Nebraska was chasing, Collins will likely not be ready to contribute at defenisve tackle in 2013, but shows he has the tools to be a starter down the road. The difference in his film between his junior and senior year is quite noticable, as the 285 pounder shows the ability to constantly be in the backfield. The four-star prospect should be able to pack on some weight in year one. Collins shows tremendous footwork, which shouldn't be surprising considering he's an excellent wrestler.
Adam Taylor
Katy HS (TX)
|In most years, Taylor would have been a top three pickup, but with the running back stable looking pretty solid (even without Heard) and Terrell Newby in the mix, Taylor isn't quite as big of a deal. That said, don't be surprised if he's a 1,200 yard rusher in a couple seasons. He's got sneaky speed and likes to run over people – arm tackles and cornerbacks just won't get it done against him.
Marcus Newby
Quince Orchard HS (MD)
|A very humble player, Newby doesn't seek attention, which kept his name out of the headlines probably more than it should have. Newby had a very impressive offer list and is the type of linebacker who can bring a crowd to their feet with one big hit or stop. He was an all-American in 2012 rightfully so. The Nebraska coaches work in the east coast paid off with this one.
Gabriel Miller
Penn HS (IN)
|People will think I'm crazy putting a long snapper in the top ten before a four-star quarterback, a pair of talented tight ends, an All-American offensive lineman, or a kid from Canada, but Miller's name will hardly come up again after NSD. It's a good thing. You don't want to know the name of your long snapper and Miller, the nation's No. 2 player in that category, shouldn't give you many reasons over the next four years (likely starting all four) to do that.


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Hello, everyone! This is Dr. Unicorn here, with a blog for Community Central! I would like to share to everyone my new wiki that I made not long ago, the Roald Dahl Books Wiki. The Roald Dahl Books Wiki is pretty much the Roald Dahl wiki but only focusing on the books that he writes, and not the movies and plays and other adaptions of his work. Here is the link to it: https://roalddahlbooks.wikia.com/
I created this wiki, because I enjoy reading the wonderful works by this amazing author, and I would like to share my knowledge to the rest of the world. So far, I have made only just one page, and that is for the BFG, but, in the future, as the community grows, I plan to create many, many more. I would like this wiki, in the future, to be a big, well-known, popular wiki, with lots of contributors.
So, if you are interested in the books of Roald Dahl, please feel free to join the wiki! We need more contributors, and more contributors mean a more successful wiki! Thank you very much!
Dr. UnicornClick this to talk to me! 22:15, July 12, 2016 (UTC)


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52 Ways to Live Success
by Jeanne Sharbuno
Published July 15, 2005 by Jaico Publishing House .
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History Created April 30, 2008 · 5 revisions
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|December 15, 2009
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|April 30, 2008
|Created by an anonymous user
|Inital record created, from an amazon.com record.


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Current Ithaca College community members may contribute stories and comments as well as view additional topics by logging in.
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The Office of Student Financial Services will be closed
Contributed by Alison Barrett on 12/15/10
The Office of Student Financial Services will be closed on December 15, 2010 from 8:30am until 10:45am so that we may attend a staff meeting. We will be open on Thursday morning, December 16, 2010, but will close from 10:45am until 1:15pm so that we may attend an all campus event. You may visit us online at our new and improved website at www.ithaca.edu/finaid. Thank you, and Happy Holidays.
© Copyright Ithaca College. All rights reserved; unauthorized use prohibited. All material on this server is produced by our community but, except for designated pages, is neither approved nor verified by Ithaca College.


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Founded in 2010, the core focus of the group has been on Hadoop and the related Big Data tools. This is a forum where individuals who are interested in Big Data can meet and network. We try to meet at least once a month to host a technical discussion on a related technology, as well as try to host other events to help foster the local Chicago Community.
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Summary of Season 1 (2006) - 2 discs
With help from Hollywood makeup tricks, this FX Networks reality series examines race and racism by having two families -- one white, one black -- trade ethnicities to experience life from the other's perspective. Sharing a California home during the course of the six-week experiment, the families are forced to engage each other in a setting that frequently produces provocative interactions and stunning revelations.
Show Details
- Cast
- Genres
- TV Shows, TV Reality Programming
- This show is
- Provocative


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Navy Paisley Toss Pillow has everything you're looking for when it comes to a quality, decorative pillow. Equally suited inside on your living room sofa or propped on an outdoor patio bench. Displaying a fun paisley pattern in shades of blue and white, this pillow offers year round decor possibilities. Featuring a weather resistant fabric to withstand the outdoor elements. Made of easy-care, spun polyester with the look and feel of cotton. Clean with 50% combination of water and mild soap or detergent. Do not use bleach on printed fabrics. Keeping outdoor pillows clean is the best thing you can do to extend the life of them. USA. Approximately 13.5" - 15" square
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TCS Freshers Recruitment Process – Assistant System Engineer Trainee – Sagar K Parmar
Sagar K Parmar, Assistant System Engineer-Trainee, Tata Consultancy Services Limited (TCSL) shares his Interview Process in this brief interview
College: Chandubhai S. Patel Insititute of Technology (CSPIT). CHARUSAT
Stream: mechanical engineering
Please tell us about your Interview procedure at TCS (Short listing procedure, GDs, Interviews, Questions).
Today i am gonna share my placement interview.
Hey Friends i got placed in my campus placement selection process in TCSL (Tata Consultancy Services Limited) And today i am going to share my interview experience.
Around 450 Students were eligible to take part in the placement procedure. It was very hectic and very exciting day for all of the candidates.
It was two day process, On first day It was 90 min online exam in which first ten minutes u have to complete Mail writing. In Mail writing they gave u one topic and after that u have to solve aptitude ( 30 questions) in remaining 80 minutes. Around 450 students gave exam and only 179 students cleared the exam and i was one of them.
Second day, interview.
There were three round of interview.
1) Technical
2) MR (Managerial Round)
3) HR (Human Resources)
We all were categorized into panels and I was waiting for my turn and at 1:30 pm my name was announced, and after that my heartbeat get fast. And suddenly one volunteer came to me and said 'lunch break'. It was 30 minute lunch break and i was seated outside room. After 45 minute again a volunteer came to me and said your name is sagar, I said yes! and he said to go into room for interview.
ME: May i come in sir?
HE: Yes, sit.
ME: Thank you sir.
HE: Have you eaten anything?
ME: No sir.
HE: Are you okay?
ME: Yes sir, It is all about my carrier that's why i am okay with it.(He Impressed)
HE: Show me your resume.
ME: I gave him.
HE: Explain your Project briefly.
ME: I explained My two projects first was solar car and second was industrial project.
HE: What have you learned from your industrial training?
ME: I explained my both training, i took two training first one was from INDIAN RAYON(A UnitOf Aditya Birla Nuvo Ltd.) and second was from ANUPAM INDUSTRY LTD. I told him that What i have learned in both training, like plant layout, product etc..
HE: Tell me about your industrial visits, if u have!
ME: I explained all (five) my visit means what i have saw and learned and what's is the environment of industry everything.
HE: What is the difference between Arc & Gas welding?
ME: I Explained.
HE: Explain Cruze Car Engine Working.
ME: I Explained.
HE: u don't mention the C & C++ in your resume
ME : i said that sir, I came from mechanical branch that's why i don't mention that. but i know the basic of it.
HE: What do you know about C?
ME: I told the function of printf and scanf and etc.
HE: Write any program in C language.
ME: I wrote a program of prime number.(He Impressed)
HE: You are a Mechanical Engineer then why do you want to join tcs?
ME: Sir, i heard from my senior that Tcs has one branch EIS (Engineering industrial services) in that branch i can work and also Tcs is a multinational company and I want to be a part of TATA group.
HE: Ok sagar, You can go now, and He asked me to get some food (With laughing)
ME: I said Thank you sir, and walked off confidently.
My interview was around 30 minutes. He was a very nice person.
After one and half hour my name was announced for MR round It means I have cleared my Technical Round. I was very happy. I go for MR round and suddenly I saw that they are taking interview through phone. I entered into the room and one person sitting in front of table and he said me please seat, i told Thank you sir. He said me that took the Phone and I took it…
HE: Good Afternoon sagar.
ME: Good Afternoon sir.
HE: My name is prakash and i am the manager and now, I am going to take your interview, So be Confident.
ME: YES sir.
HE: Tell me about your self.
ME: I am 20 year old, i am basically from Junagadh. I am about to complete my B.Tech. If I talk about my academic carrier, I have done my schooling from Nutan high school talala, and 11 & 12 from Alpha high school Junagadh. And in my engineering i have learned lots of thing in last three year. I gain much more knowledge and now I want to apply my knowledge which I have acquired in last three year. In my academic carrier my favorite subjects are Design, Production and I.C. Engine. I have done some project also in last three year,If I talk about my project,In second year i have made a war robot for the event cognizance which is organized by our university and we got 3rd rank in that event. In third Year, We have made a Solar Car with one seat capacity as a team and We have participated in ESVC (Electrical Solar Vehicle Championship) event organized by ISIE(Imperial Society Of Innovative Engineers) And Were champion of all over Asia with four Awards.
Suddenly He said me Ok and asked…
HE: What is your role in your team?
ME: sir, My role in the team as a designer of steering system and in fabrication department.
HE: Which kind of steering system and Why?
ME: I explained it briefly.
HE: If i will ask you after One year then can you explain me this?
ME: Yes, of course sir.
And then he hold me for 7 to 8 minutes, In this time one sitting person looking in front of me that i am a prisoner. After some time he came back and told me…..
HE: Ok, Have You done any other project?
ME: yes sir.
HE: can You Explain it?
ME: I explained my another industrial project.
HE: Ok sagar, I am done. Have you any question for me?
ME: No sir.
HE: Nice to talk with you sagar, Now you give phone who is sitting in front of you.
ME: Ok sir, & Thank you sir, It's my pleasure to talk With You sir.
After that I walked off confidently.
After Two and half hour my name was announced for HR interview. It was only for just formalities.
HE: Good Evening sagar.
ME: Good evening sir.
HE: How was your aptitude test ?
ME: It was good sir.
HE: How was your interview?
ME: It was also good sir.
HE: Here's a bond of 2 years…You're Ok with it?
ME: Yes sir.
HE: Have you talked with your father about interview and condition ?
ME: Yes sir.
HE: Has he any problem if We send you out of Gujarat?
ME: No sir.
HE: Why do you want to join out company ?
ME: same as i above told.
HE: If any discrepancy found in the given information, You will be rejected.
ME: Yes sir.
HE: Have you any questions?
ME: No sir, I had doubt but all are clear at pre-placement talk.
HE: Ok, You can go now.
ME: Thank You sir.
At 9:30 pm, HR was came and start to announce the selected name, And I was waiting for my name. I was happy because my friends name was announced but We all are waiting for my name and finally HR said parmar sagar and Me and my friends shouted loudly, Because We all are happy..
What and how many internships and projects you did at college? How did you get them?
I did two internship and two projects.
How did you prepare for the placement season? What advice would you give to your juniors regarding the placement season?
Be confident,
make simple resume,
knowledge about your favorite subjects should be more.
What's the role of academics in getting a good placement?
My internship and my projects
Would you like to give any general advice to your juniors?
Be confident.


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The Jackson Laboratory has been awarded $28.3 million from the NIH to expand the Knockout Mouse Production and Phenotyping Project, which was launched in 2011. Since then, researchers there have made and extensively phenotyped 833 knockout mouse strains from embryonic stem cells. Now, they'll capitalize on CRISPR/Cas9 technology to generate another 1,000 strains in the next 5 years.
- ©2016 American Association for Cancer Research.
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Perth, CBD, Perth Western Australia 6000
1300 653 696
Tours & Charters
Perth Bus and Coach Charters cater for all aspects of the industry including Weddings, Swan Valley Winery Tours, Hens Nights, Bucks Nights, Concert Transfers, Adventure Tours to Karigini and Ningaloo, Fishing Charter Packages, Inbound Tours, Corporate Clients, Motivational Packages, Seniors Tours, School Camps, Sporting Transfers, Government Departments. Put simply there is nothing that the team at Perth Bus and Coach Charters cannot assist you with. Any size vehicles for any occasion. Mini Buses 12 to 25 seat, Luxury Coaches 33 to 63 seat, Limousines. From 12 to 1000 people we can assist in moving them.


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One would think mobile technology would explode on college campuses in Alaska, Arizona, Arkansas, Idaho, Hawaii – everywhere, but designing and distributing applications still has yet to fully catch on as a valuable support tool. Slowly, however, schools have started taking advantage of what smartphones have to offer pretty much anyone affiliated with — or hoping to be affiliated with — their educational opportunities. Mobile applications especially streamline and render (somewhat) less painful all the little stressors of college life, making them an ideal choice for the tech-savvy schools out there striving for meaningful relevance. Because the format offers some pretty potent potential, many included some features to make themselves stand out from the other mobile applications out there. Whether they get experimental and creative with the expected offerings or veer off into a specialty section, the following official college presences on iPhones, Androids, and the like deserve some extra attention.
Monash University:
Smartphone users on this Australian campus enjoy access to alumni and computer science major James Eunson's sophisticated application, which includes almost anything they could possibly want. Thanks to the GPS, anyone can map their location on school grounds and figure out how to get to their requested buildings. Other offerings include an event calendar, directory, access to news, shuttle schedules, and course listings.
Harvard University:
Lauren Landry at BostInno set about comparing and contrasting the official mobile applications of all Boston-area colleges, lauding Harvard's suite of several as a real standout. Both the law school and the school of public health boast their very own downloadables with content unique to their needs, but the more general ones involve a thoroughly detailed tour of campus (complete with histories!), networking with alumni, following the latest news and events, and even a mini social media feature.
Oxford University:
Really more of a mobile website than an application, but we'll let that slide because it stands amongst the best examples of how colleges and universities can harness smartphones to make life that much easier for potential, current, and former students, faculty, and staff. Through its rich, streamlined interface, users browse the legendary library, watch live webcam feeds from around campus (no, they aren't in co-ed showers, pervert), check the weather, listen to podcasts, learn about public transportation routes, read the news, and plenty of other essentials.
Kaplan International Colleges:
Available to Kaplan International College students in Ireland and the UK with iPhone or iPod Touch access, the official app seeks to quell some of the anxieties related to making the transition to a brand new nation. Not only do its maps help them navigate their chosen campuses, they also guide them towards cool local places to hang out, get food, and go shopping for both required and not-so-required items. One of its most innovative features, however, is the translation feature, which assists non-native speakers in finding the best phrases and words for the appropriate situation — though it mostly covers the most common scenarios they'll encounter.
Southampton University:
MySouthampton boasts the expected event calendar, GPS-synched maps, bus schedule, alerts, weather reports, directories, course outlines, and the like — all pretty standard stuff that any decent university app should provide. But what makes it one of the more unique and notable official college mobile resources is the Friend Finder feature. No doubt inspired by the popularity of Facebook, Yelp, and FourSquare check-ins, this micro-scale social media site connects students who want to meet up with classmates and friends on campus for work or play purposes.
Stanford University:
Stanford's more general application blends the personal with the academic, as it allows students to use it as a planner and calendar in addition to enjoying quick access to campus resources. But its crowning glory of harnessing mobile technology comes in a groundbreaking partnership with Bling Nation over anything else it has put out thus far. With a simple tap of a tiny microchip, students pay up at participating Palo Alto businesses, watching their money filter out through PayPal rather than directly from their bank accounts. The service's debut met with raucous support for its time-saving measures that also, more importantly, help protect their identity just a little more adroitly than a credit or debit card.
Ohio State University:
Buckeyes fans just love the crowdsourced O-H-I-O! application, whose modus operandi departs completely from the usual official university mobile fare. All it contains is a camera and a photo gallery, where students, faculty, staff, parents and alumni photograph themselves enthusiastically executing their iconic (and eponymous!) rallying poses. Users have contributed well over 4,000 images so far, hailing from all sorts of wonderful and beautiful locations across the globe, which they can browse completely for free as a means of promoting harmony and school spirit.
Cleveland State University:
Like many notably wired colleges and universities these days, Cleveland State University's devotion to mobile technology extends to multiple apps. Beyond the expected, one of its "satellite†offerings even won the 2011 Ohio Mobile Apps Development Contest hosted by eTech Ohio. Available for the iPhone and Android phones, Cleveland Historical pulls from the school's extensive archives to share the city's past and present with users who don't even associate with CSU. The Center for Public History + Digital Humanities provides the veritable virtual tour guide free of charge in order to promote education in urban spaces.
University of Virginia:
Numerous media outposts oftentimes tout this official school smartphone application as one of the best, probably because it wound up one of the very first to utilize augmented reality technologies to make the experience unique. While on campus, anyone with access to it can hold their camera up to an unknown building and receive the basic details. Very handy for freshmen and transfers! Users also enjoy fingertip access to news, pictures, alerts, club listings, recordings of fight songs, admissions advice, directories, alumni information, and other resources spanning the spectrum of fun and necessary. One of the most notable, however, hooks students up with support services, such as escorts or rides home and peer counseling, when they need a helping hand with their safety and mental health.
Cambridge University:
Cambridge University's world-class English department offers two amazing, game-changing applications for their students (and teachers) learning and teaching ESL. The best-selling English Grammar in Use series, which covers tests and activities, even assists native speakers with quick pointers regarding the best phrasing for particular situations. For such a deliciously multinational campus, this reaching out to its non-native English-speaking community is no-doubt a thoroughly appreciated move. Probably on- and off-campus alike.


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Lacresha, Luke's 18 year-old daughter, opens up in a very candid and almost comedic tone about her father's recent arrest and tells DJ Laz on Power 96 this morning.
"Daddy didn't pay child support, so Daddy has to go to jail. He owes money for his baby daughter Brooklyn and he's not getting out until he pays it. It all basically caught up to him. He went to file some paperwork in court yesterday and they ended up arresting him"
Luther "Uncle Luke†Campbell was arrested in Miami yesterday for alledgedly failing to pay child support in excess of $10,000 for his baby daughter Brooklyn.
Campbell was taken into custody just after 6:00 pm yesterday (February 17).
According to his older daughter (Lacresha), he will be let out of jail as soon as he pays the $10,000.


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Health insurer Cigna is helping us create our own New Years NON-resolution this year.
Cigna's Facebook app is very simple: You enter one thing that you don't want to change about yourself. At the end of 2012, Cigna will send you a reminder about your non-resolution to make sure you haven't changed.
This app is part of Cigna's 'Go You' campaign which focuses on celebrating individuality and empowering their members to focus on what makes them different.
What do you think about this app and the Go You campaign in general? Is it the right approach for a health insurance company?


text: open records laws Nixon urges renewal of some Sunshine Law exemptions By Associated Press • Jan 4, 2013 Jacob Fenston / KBIA Gov. Jay Nixon is urging renewal of exemptions from Missouri's open records law for security systems of government buildings and policies for responding to terrorism. The exemptions protecting such information from disclosure expired at the end of 2012. Nixon has scheduled news conferences on the topic today at the University of Missouri-St. Louis and the Missouri State Highway Patrol General Headquarters in Jefferson City. Law enforcement and public school district officials are scheduled to take part.


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The Mount Carmel Academy Cubs defeated the Cabrini Crescents at Cabrini in straight sets (25-10, 25-11, 25-10) to improve to 8-0 on the season.
"We've been working hard," Mount Carmel coach April Hagadone said. "We're just working on getting ourselves better at this moment."
Mount Carmel pulled away in the first set early, at one time converting 12 straight points to build up a 13-1 lead. Cabrini (0-3) staged a mini rally toward the end and carried some momentum into the early part of the second set, but the Cubs again went on a long run to take a 2-0 lead in the match.
Mount Carmel executed their attack very efficiently. Everyone seemed to be in the right place at the right time nearly the entire match.
"We're getting the big things right, and we're now working on the little things," Hagadone said. "They're striving to do their best. They're really working hard. I'm proud of my team's performance today."
Megan Davenport and Marissa Lagasse tied for the team lead with 10 kills. Davenport also had five blocks. Jillian Clark had 24 assists while Olivia Smit contributed with 13 digs and Katie Kampen chipped in with three aces.
"Were really coming together as a team," Davenport said. "We're meshing together. We found our rhythm tonight. It was really great teamwork."
Mount Carmel will travel to St. Joseph's Academy on Thursday and try to maintain their perfect start. Cabrini will continue to look for their first victory when they take on E.D. White at home Monday.


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Mr. KERRY. Mr. President, the Centers for Medicare and Medicaid Services, CMS, recently announced that nearly three-quarters of Medicare enrollees will see no increase in their Medicare Part B premium in 2011.
This group of beneficiaries is protected by a ``hold harmless'' provision in the law for years when there is no increase in Social Security checks. As a result, these beneficiaries will continue to pay the same monthly premium of $96.40 that they have paid since 2008.
Unfortunately, 27 percent of Medicare beneficiaries do not receive this ``hold-harmless'' protection and will see their monthly premiums disproportionately increase to $115.40 to shoulder the full load for those beneficiaries who are held harmless. This represents an increase of nearly 19 percent over the past two years with no cost of living adjustment to their retirement pensions or annuities.
This inequity in the law negatively affects new Medicare enrollees, low-income beneficiaries who receive Medicare and Medicaid, higher income enrollees who already pay higher premiums, and seniors who do not receive Social Security, such as federal, state, and local government retirees.
I believe we have a responsibility to protect all Medicare beneficiaries from premium increase, especially during these tough economic times when every penny counts. A premium increase for many seniors would mean choosing between food and medicine and that's a choice they should not have to make.
That is why today I am introducing the Medicare Premium Fairness Act. This legislation would restore fairness to our Medicare system and put money in the pockets of 12 million seniors and individuals with disabilities who desperately need it. It would correct this inequity in the law by applying the ``hold harmless'' provision to all Medicare beneficiaries, so that no enrollee will pay a monthly premium more than $96.40 in 2011.
The Medicare Premium Fairness Act is cosponsored by Senator Dodd and Senator Casey, both of whom have been integral to the development of this legislation. Our legislation is supported by twenty four organizations that represent retirees and senior citizens across the country. I would like to thank all of the number of organizations who have endorsed our legislation today, including the American Federation of State, County and Municipal Employees, AFSCME, the National Active and Retired Federal Employees Association, NARFE, and the National Committee to Preserve Social Security and Medicare, NCPSSM.
Now is the time to protect all Medicare beneficiaries from substantial and unfair Part B premium increases next year. I look forward to working with my colleagues in the Senate to pass the Medicare Premium Fairness Act before the end of the year.
Source: http://thomas.loc.gov


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: Rumor:
Rumor Thread 3.0: Gagner fit for a King?
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I don't really see why anyone thought there would be trades made on this day. The only way I could see this day having any impact would be if the trade involved any players named to their country's Olympic team. Otherwise, teams are just trading for a player they'll have to pay and take a cap hit for during the 3 week period of the Olympic break where the player can't play or even practice for them.
Players can start practicing with their teams on February 19 but the teams can't start trading again until February 24 so it would give a team five days with a player during a time when a lot of clubs will be holding in-season mini-camps so it could be seen as a good time to integrate the player with your club.
Clearly that wasn't enough of an incentive to trigger any major deals, however.
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Carolinas Medical Center is the lead enrolling site for METRC
The Department of Orthopaedic Surgery at Carolinas Medical Center is a founding member of the Major Extremity Trauma Research Consortium (METRC), funded by the U.S. Department of Defense. The Consortium was established to address some of the immediate research needs of the military in the acute management and long-term outcomes of severe limb injuries.
Michael Bosse, MD, director of orthopaedic trauma service and orthopaedic clinical research at Carolinas Medical Center, is the METRC co-principal investigator and clinical chair. Carolinas Medical Center is currently enrolling patients in eight of the active studies – focusing on infection prevention and treatment, bone defect reconstruction, and recovery following major limb trauma. Dr. Bosse is the principal investigator on three of these studies.
Establishing Treatment Standards
One of the current studies is testing the effectiveness and implementation of the Trauma Survivors Network, a collaborative care, multi-modal intervention designed to improve acute and post-acute care following major orthopaedic trauma.
This study builds on evidence that outcomes in complex medical conditions improve when "informed, activated" patients interact with "prepared, proactive practice teams." Carolinas Medical Center serves as an intervention site in the effort to examine the impact of this innovative psychosocial intervention.
The overall goal of METRC is to produce the evidence needed to establish treatment guidelines for the optimal care of the injured service member and, ultimately, to improve the clinical, functional and quality of life outcomes of both service members and civilians who sustain high-energy trauma to the extremities. METRC consists of a network of clinical centers from across the United States, with the Johns Hopkins Bloomberg School of Public Health serving as the coordinating center. Carolinas Medical Center is one of 22 core civilian trauma centers, four military treatment centers and 30 associate Level I trauma centers that comprise the research group.
To date, METRC has enrolled more than 1,000 patients into the prospective studies, with Carolinas Medical Center the lead enrolling site. "The opportunity to work with the top trauma centers in the nation and to be associated with the lead military treatment facilities in a project of this magnitude really highlights the capacity and capabilities of Carolinas Medical Center," Dr. Bosse said. "The project is currently funded with more than $80 million in Department of Defense and National Institutes of Health grants. The Consortium is historic in that orthopaedic surgery has never had so much funding allocated to one group in support of critical clinical research."


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Actomyosin contractility controls cell surface area of oligodendrocytes
To form myelin oligodendrocytes expand and wrap their plasma membrane multiple times around an axon. How is this expansion controlled?
Here we show that cell surface area depends on actomyosin contractility and is regulated by physical properties of the supporting matrix. Moreover, we find that chondroitin sulfate proteoglycans (CSPG), molecules associated with non-permissive growth properties within the central nervous system (CNS), block cell surface spreading. Most importantly, the inhibitory effects of CSPG on plasma membrane extension were completely prevented by treatment with inhibitors of actomyosin contractility and by RNAi mediated knockdown of myosin II. In addition, we found that reductions of plasma membrane area were accompanied by changes in the rate of fluid-phase endocytosis.
In summary, our results establish a novel connection between endocytosis, cell surface extension and actomyosin contractility. These findings open up new possibilities of how to promote the morphological differentiation of oligodendrocytes in a non-permissive growth environment.
See related minireview by Bauer and ffrench-Constant:
During their life cycle many cells undergo dramatic changes in their cell morphology including rapid alterations in shape and surface area. One way by which cells change their surface area is to alter membrane traffic between surface and interior. For example, loss of integrin-mediated adhesion during tumor cell growth triggers the rapid caveolin-mediated endocytosis that leads to cell rounding
A striking example of cell-shape change is the morphological differentiation of oligodendrocytes during the development of the central nervous system. First, small and bipolar oligodendrocyte precursor cells (OPCs) migrate into the brain, where they differentiate into oligodendrocytes and expand their plasma membrane many folds in order to wrap it several times around an axon
Since the generation of myelin occurs at the appropriate time during neuronal development, it is assumed that neuron-glia communication coordinates this process. However, in cell culture oligodendrocytes differentiate and extend large myelin membrane sheets in the absence of neurons
In this study, we tested how the extracellular environment controls cell shape and membrane traffic in oligodendroglial cells.
The following primary antibodies were used: actin (mouse monoclonal IgG, Sigma, St. Louis, MO), O1 (mouse monoclonal IgM), MBP (mouse monoclonal IgG; Sternberger Inc., Lutherville, MD), nonmuscle myosin II heavy chain A and B (polyconal Covance, Berkely, CA) and betaIII-Tubulin (mouse monoclonal IgG, Sigma, St. Louis, MO). Secondary antibodies were purchased from Dianova (Hamburg, Germany).
Preparation of acrylamid gels on glass coverslips
To prepare acrylamid gels on glass coverslips and crosslink adhesion proteins to the gels, we adapted the protocol by
Crosslinking of adhesion proteins on polyacrylamid gels
To prevent polyacrylamid gels from drying, they were covered with 150 μl 1 mg/ml sulfo-SANPAH (Pierce, Rockford, IL) immediately after polymerisation. The gels were then places under an ultraviolet lamp at approximately 10 cm distance and irradiated for 10 min. The polyacrylamid gels were immersed in 1 ml sterile 200 mM HEPES pH 8.6 in multi well plates (12 well, Cellstar, Greiner Bio-One). The HEPES solution was aspirated and 1 ml 70% Ethanol was added for 1 min to sterilize the polyacrylamid gels. To remove residual ethanol and sulfo-SANPAH the gels were washed overnight in 1 ml sterile 200 mM HEPES pH 8.6. Coating with poly-L-lysine was done for 1 h at RT. The gels were rinsed once with de-ionized water and dried for 10 min before plating with cells.
Cell culture and immunofluorescence
The oligodendroglial cell line, Oli-neu, was cultured on poly-L-lysine as described previously
The effects of RGD-binding integrins were assessed by treating Oli-neu cells for 8 h with 100 nM RGD-peptide (#05231701, Calbiochem) or with the inactive control RAD-peptide (#03340052, Calbiochem). Poly-L-lysine pre-coated glass coverslips were incubated overnight at RT in 10 ng/ml to 500 ng/ml Chondroitin sulfate proteoglycans (CSPGs) (Proteoglycan Mix, Millipore, Billerica, MA), dried and rinsed with PBS before plating with cells. Cells were plated in a density of 50 000 per 12 well (3.8 cm2).
siRNA nucleofection
Smart pool siRNA targeting myosin II-A, myosin II-B (directed at the mouse sequences (accession numbers NM_181327 and NM_175260, respectively) and of control non-targeting siRNA pool were purchased from Dharmacon (Dharmacon RNA Technologies, Lafayette, CO). Electroporation was performed using the basic neuron transfection Kit (Amaxa Biosystems, Cologne, Germany) and Amaxa programm O-05 (Amaxa Biosystems, Cologne, Germany) according to the manufacturer's protocol. Briefly, per transfection Oli-neu cells (2 × 106) were harvested, resuspended in 100 μl resuspension buffer and mixed with 160 pmol siRNA per transfection. The transfection was repeated after 72 h. For electroporation of primary oligodendrocytes, 1.5 × 106 cells were collected, nucleofected with both myosin II-A and II-B or control siRNA and subsequently cultured for 3 d.
Cells were plated on coverslips and analysed for surface extension and dextran uptake after another 24 h. Knock down efficiency was controlled by western blot analysis 24 h or 48 h after the second transfection.
Endocytosis assays
Endocytosis was assessed by incubating Oli-neu cells for 15 or 30 min at 37°C with rhodamin-labelled Dextran 10K (Molecular Probes) in culture medium. Cells were subsequently washed and fixed, followed by microscopic analysis. Image processing and analysis was performed using Meta Imaging Series 6.1 software (
Microscopy and analysis
Fluorescence images were acquired using a Leica (Nussloch, Germany) DMRXA microscope and a confocal laser scanning microscope (TCS SP equipped with AOBS, Leica) with 40× and 63× oil plan-apochromat objective (Leica), respecively. Image processing and analysis was performed using Meta Imaging Series 6.1 software (Universal Imaging Corporation). Quantification of fluorescence intensities was performed as described previously
Gel elasticity measurements
An atomic force microscope (AFM; NanoWizard, JPK Instruments), mounted on a Zeiss Axiovert 200 M (Carl Zeiss) was used to perform elasticity measurement. 5 micron diameter silica beads (Kisker) were attached to tip-less cantilevers (MLCT, Veeco) using epoxy glue (Araldit). Cantilever spring constants were determined using the equipartition theorem. Polyacrylamide gels were probed with a maximum indentation force of 1 nN at no less than 5 locations. Each indentation curve was fitted (Igor Pro, Wavemetrics) according to the Hertz model
Regulation of cell surface area by the integrin binding RGD-peptide
We started assessing the influence of integrins on cell surface area by treating the oligodendroglial cell line, Oli-neu, with a monovalent integrin ligand (RGD-peptide) or a non-binding control (RAD-peptide). Morphological analysis of Oli-neu cells grown on fibronectin or poly-L-lysine coated coverslips revealed a significant reduction in cell surface area after treatment with RGD-peptide compared to the inactive RAD-peptide (Figure
Figure 1
Integrins in cell surface expansion and endocytosis in Oli-neu cells
Integrins in cell surface expansion and endocytosis in Oli-neu cells. (A) Oli-neu cells were treated for 8 h with 100 nM RGD-peptide, 100 nM inactive RAD-peptide, 10 μM Y27632 and 50 μM blebbistatin (blebb) as indicated. Cells were stained with Alexa Fluor 488 conjugated wheat germ agglutinin (green). Scale bar, 10 μm. (B) Changes in relative surface area were quantified by image analysis as described in Material and Methods. (C) Changes in relative surface area shown for cells grown on fibronectin. (D) Quantitative analysis of dextran uptake (30 min) in Oli-neu cells treated with 100 nM RGD-peptide or inactive RAD-peptide for 8 h. Values represent means ± SEM (n > 70 cells, **p < 0,01; ***p < 0,001).
Signals from integrins to the Rho family GTPases regulates morphological differentiation of oligodendrocytes
Matrix rigidity and actomyosin contractility control cell surface area
There are number of recent studies demonstrating that cells sense and response to the stiffness of their substrates
For example, matrix elasticity directs mesenchymal stem cell lineage specification
Since integrins in conjunction with actomyosin contractility are implicated in the sensing of these physical matrix properties
Figure 2
Matrix rigidity regulates cell surface area and endocytosis in Oli-neu cells
Matrix rigidity regulates cell surface area and endocytosis in Oli-neu cells. (A) Quantification of the elastic shear moduli of polyacrylamid gels on glass coverslips with varying amounts of bisacrylamid. Values represent means ± SD (n > 30 measurements). (B) Oli-neu cells were cultured for 1 d on polyacrylamid gels of different rigidities (using bisacrylamid varying from 0,5% to 0,01%) and analyzed for surface area differences by staining with Alexa Flour 488 conjugated wheat germ agglutinin (green). Scale bar, 10 μm. (C) Quantification of the surface area of Oli-neu cells on polyacrylamid gels of different rigidities (mean ± SEM; n > 100 cells, ***p < 0,001). (D+E) Cells were cultured for 1 d on polyacrylamid gels of different rigidities by varying the amount of bisacrylamid. Changes in the amount of dextran uptake ((D) 15 min and (E) 30 min) were quantified. Values represent the mean ± SEM (n > 60 cells from three independent experiments, ***p < 0,001). (F) Quantification of cell surface area of Oli-neu cells cultured on polyacrylamid gels for 1 d and treated for 10 h with 10 μM Y27632 or C3 transferase (mean ± SEM; n > 100 cells, *p < 0,05, **p < 0,01, ***p < 0,001). (G) Quantitative analysis of surface area changes of Oli-neu cells cultured for 1 d on polyacrylamid gels and treated with 50 μM blebbistatin (blebb) for 10 h (mean ± SEM; n > 60 cells, ***p < 0,001). (H) Oli-neu cells were cultured on polyacrylamid gels of different rigidities, treated with RGD-peptide or inactive RAD-peptide and changes in relative surface area were quantified. Values represent the mean ± SEM (n > 80 cells, *p < 0,05, **p < 0,01, ***p < 0,001).
Next, we tested whether the inhibition of actomyosin contractility influences the effects of matrix rigidity on cell surface area. We observed that the inhibition of either Rho/ROCK signaling by C3 transferase and Y27632 or myosin II by blebbistatin restored cell surface expansion on soft matrices (Figure
By measuring the elastic modules of acrylamide gels with atomic force microscopy, we ruled out that the RGD-peptide affected matrix rigidity (the elastic module of 0.75% gels was 7761 +/- 2200 in the presence of the RGD-peptide).
Next, we investigated the effects of matrix rigidity on membrane sheet expansion in primary oligodendrocytes. Again, a considerable decrease in sheet size accompanied decreasing matrix rigidity (Figure
Figure 3
Matrix rigidity regulates cell surface area in primary oligodendrocytes
Matrix rigidity regulates cell surface area in primary oligodendrocytes. (A) Primary oligodendrocytes were cultured for 3-4 d on polyacrylamid gels of different rigidities and analyzed for the expansion of myelin membrane sheets by staining for MBP (green). Scale bar, 20 μm. (B) The relative sheet size of primary oligodendrocytes was quantified. Values represent the mean ± SEM (n > 60 cells, ***p < 0,001).
Overcoming chondroitin sulfate proteoglycans inhibition of cell surface spreading by myosin II inhibition
One group of molecules that contribute to the non-permissive growth properties in the CNS environment are chondroitin sulfate proteoglycans (CSPG)
We, therefore, determined the effects of CSPG on the surface area of Oli-neu cells by plating the cells on different concentrations of CSPG. We observed that the cell surface area decreased with increasing concentration of CSPG. The highest concentration of 500 ng CSPG resulted round cells with diameters half that of control cells (Figure
Figure 4
Chondroitin sulfate proteoglycans reduce cell surface area in Oli-neu cells
Chondroitin sulfate proteoglycans reduce cell surface area in Oli-neu cells. (A) Oli-neu cells were cultured for 12 h on coverslips coated with different concentrations of chondroitin sulfate proteoglycans (CSPG), stained with Alexa Fluor 488 conjugated wheat germ agglutinin (WGA) and analyzed for changes in cell surface area. Scale bar, 10 μm. (B) Quantification of the surface area of Oli-neu cells cultured on CSPG coated coverslips with or without 10 μM Y27632, C3 transferase or (C) 50 μM blebbistatin (means ± SEM; n > 80 cells, *p < 0,05, **p < 0,01, ***p < 0,001).
Blebbistatin is a small molecule inhibitor with high affinity and selectivity towards myosin II
Figure 5
Myosin II regulates cell surface area and endocytosis in Oli-neu cells
Myosin II regulates cell surface area and endocytosis in Oli-neu cells. (A+B) Western blot analysis of myosin (myo) IIA and IIB after siRNA knock down in Oli-neu cells as compared to actin as a loading control. (C) Control siRNA, siRNA directed against myosin (myo) IIA, myosin (myo) IIB or both were nucleofected into Oli-neu cells. The cells were subsequently cultured on CSPG coated coverslips and changes in cell surface area were quantified after 16 h (means ± SEM; n > 100 cells, n.s. not significant, ***p < 0,001). (D) Quantification of dextran uptake (30 min) in Oli-neu cells cultured on CSPG coated coverslips (means ± SEM; n > 100 cells, **p < 0,01, ***p < 0,001). (E) Quantification of dextran endocytosis in Oli-neu cells cultured on CSPG coated or control coverslips and treated with 10 μM Y27632 or 50 μM blebbistatin for 1 h (means ± SEM; n > 80 cells, *p < 0,05,***p < 0,001). (F) Quantitative analysis of the endocytosis of dextran in Oli-neu cells nucleofected with control siRNA or siRNA against both myosin IIA and IIB (means ± SEM; n > 80 cells from 2 independent experiments, ***p < 0,001). Scale bar 20 μm.
To analyze whether the changes in cell surface area again correlate with changes in fluid-phase endocytosis, we analyzed the rate of dextran uptake in Oli-neu cells cultured on CSPG. We found that dextran was taken up more efficiently with increasing concentrations of CSPG (Figure
Inhibition of actomyosin contractility promotes spreading of myelin-membrane sheets on a non-permissive substrate
Next, we used primary cultures of oligodendrocytes for our experiments. These cells differentiate within a few days from cells with multiple branches to myelin-membrane sheet producing cells. In cell culture the differentiation of oligodendrocytes follows a default pathway and occurs in the absence of extrinsic signals from neuronal cells.
When primary cells were treated with blebbistatin or Y27632 cell surface area did not change significantly. We analyzed whether growth on a non-permissive substrate suppresses myelin-membrane extension and if so, whether inhibition of actomyosin contractility could overcome the block.
When primary oligodendrocytes were cultured on 500 ng CSPG for 3 days (50 000 cells/3.8 cm2) there was a significant inhibition of membrane sheet extension (Figure
Figure 6
Inhibition of Myosin II promotes spreading of myelin-membrane sheets on CSPG
Inhibition of Myosin II promotes spreading of myelin-membrane sheets on CSPG. (A) Primary oligodendrocytes were cultured on CSPG coated or control coverslips treated with 10 μM Y27632 or 50 μM blebbistatin 2 h after seeding, stained for MBP and analyzed for changes in the size of myelin membrane sheets. Changes in cell surface area were quantified after 2-3 days. Values represent means ± SEM (n > 60 cells, n.s. not significant, ***p < 0,001). (B, C) Primary oligodendrocytes were nucleofected with siRNA directed against both myosin (myo) IIA and IIB or control (Ctrl) siRNA. The cells were subsequently cultured on CSPG coated or control coverslips and membrane sheet size was analyzed after 3 d. (C) Quantitative analysis of membrane sheet size (means ± SEM; n > 30 cells, *p < 0,05). (B) Primary oligodendrocytes stained with O1 antibody to visualize membrane sheets. Scale bar 20 μm.
Next, we analyzed whether treatment with inhibitors to block actomyosin contractility promoted the spreading of membrane sheets on CSPG coated coverslips. Indeed, inhibitors of the Rho/ROCK pathway and myosin II were able to almost completely overcome the inhibition of cell surface expansion induced by CSPG (Figure
To confirm the role of myosin IIA and/or IIB we performed siRNA knock-down experiments in primary cells. Knock-down of myosin IIA and IIB promoted cell surface extension on CSPG as observed for Oli-neu cells (Figure
In this study, we show that cell surface area of oligodendrocytes is critically dependent on actomyosin contractility and is regulated by the physical properties of the supporting matrix. Furthermore, we find that chondroitin sulfate proteoglycans (CSPG), molecules associated with non-permissive growth properties within the central nervous system (CNS), block cell surface spreading. In addition, we observed that the reductions of plasma membrane area were accompanied by changes in the rate of fluid-phase endocytosis. We found that this form of endocytosis is dependent on actomyosin contractility and possibly also on integrins. A possible explanation is that actomyosin contractility pulls membrane into the cell and thereby accelerates vesicle budding. Loss of integrin-mediated anchoring to the extracellular matrix may increase these pulling forces of the actin cytoskeleton. We show that this mechanism is important for cell surface spreading of Oli-neu cells, but it is likely to be involved in the control of cell surface area in other systems. It may be particularly relevant in processes where rapid changes of cell surface area occur, for example in a blood vessel or a bladder
Previous work shows that extracellular matrix proteins, like laminin, promote the formation of myelin membrane sheets in oligodendrocytes by its interaction with integrin α6β1
In addition to signals from the extracellular matrix, paracrine signals from oligodendrocytes may also regulate myelin-membrane extension. Interestingly, the effects of the CSPG peptide on oligodendrocyte cell surface area was not observed when cells were grown at a high density, indicating oligodendrocyte present factors to neighboring cells that are able to overcome the inhibitory cues.
Integrin-mediated cell attachment is known to regulate endocytosis and cell surface shape. A striking example of the importance of this mechanism is the loss of integrin-mediated adhesion during tumor growth, which triggers rapid endocytosis and cell rounding
The finding that actomyosin contractility acts downstream of integrins is consistent with a report describing a signal transduction pathway from integrins to Fyn that facilitates RhoA GTPase inactivation and the morphological differentiation of oligodendrocytes
In the adult brain OPCs are kept in an undifferentiated state. This may in part be due to the presence of myelin from mature oligodendrocytes that blocks their differentiation
We do not know by what means CSPGs affects cell surface size, but the finding that knocking down myosin II overcomes CSPGs inhibitory effects points to a role of actomyosin contractility in this process. Earlier work examining the role of CSPGs on axon outgrowth suggested that CSPGs interfere with extracellular matrix/integrin interactions
Indeed, increased integrin expression is sufficient to eliminate the inhibitory effects of CSPGs on neuronal growth cone function
Our results demonstrating that inhibition of Rho/ROCK/myosin II activity is able to overcome a non-permissive growth property of the extracellular environment on oligodendrocytes extends the role of this system in cellular regeneration.
These findings not only show that the actomyosin system plays a role in cell surface spreading of oligodendrocytes, but also point to potential target for therapeutic interventions. However, we do not yet know whether the inhibition of actomyosin contractility affects the ability of oligodendrocytes to wrap their plasma membrane around an axon to form compact myelin. Clearly, in vivo studies are now required to determine whether inhibition of actomyosin contractility promotes myelin repair in the CNS.
In summary, we find that cell surface area depends on actomyosin contractility and is regulated by physical properties of the supporting matrix. CSPG blocks cell surface spreading, but the inhibitory effect of CSPG on plasma membrane extension is prevented by treatment with inhibitors of actomyosin contractility and by RNAi mediated knockdown of myosin II. These results establish a novel connection between cell surface extension and actomyosin contractility in oligodendrocytes and open up new possibilities of how to promote the morphological differentiation of oligodendrocytes in a non-permissive growth environment.
Authors' contributions
AK performed the experiments, analyzed the data, drafted the manuscript; JH performed the atomic force microscopy measurements; DF performed experiments, analyzed the data and approved the final manuscript; MS designed and coordinated the work and wrote the manuscript. All authors read and approved the final manuscript.
We thank G. Schulz for technical assistance. S. Nawaz for comments on the manuscript. The work was supported by the Deutsche Forschungsgemeinschaft (SFB 523), ERC Starting Grant and the EMBO YIP.
Phospho-caveolin-1 mediates integrin-regulated membrane domain internalization
Integrin-mediated adhesion regulates membrane order
Arf6 and microtubules in adhesion-dependent trafficking of lipid rafts
Endosomal recycling controls plasma membrane area during mitosis
Mechanisms of axon ensheathment and myelin growth
Wrapping it up: the cell biology of myelination
The oligodendrocyte and its many cellular processes
Emergence of three myelin proteins in oligodendrocytes cultured without neurons
Adhesion molecules in the regulation of CNS myelination
Signaling from integrins to Fyn to Rho family GTPases regulates morphologic differentiation of oligodendrocytes
Neuron to glia signaling triggers myelin membrane exocytosis from endosomal storage sites
Rho regulates membrane transport in the endocytic pathway to control plasma membrane specialization in oligodendroglial cells
Distinct endocytic recycling of myelin proteins promotes oligodendroglial membrane remodeling
Ceramide triggers budding of exosome vesicles into multivesicular endosomes
Effects of substrate stiffness on cell morphology, cytoskeletal structure, and adhesion
Lines of murine oligodendroglial precursor cells immortalized by an activated neu tyrosine kinase show distinct degrees of interaction with axons in vitro and in vivo
Myelin basic protein-dependent plasma membrane reorganization in the formation of myelin
Atomic force microscopy probing of cell elasticity
Cell differentiation through tissue elasticity-coupled, myosin-driven remodeling
Matrix elasticity directs stem cell lineage specification
Matrices with compliance comparable to that of brain tissue select neuronal over glial growth in mixed cortical cultures
Local force and geometry sensing regulate cell functions
Cell locomotion and focal adhesions are regulated by substrate flexibility
Myelin-, reactive glia-, and scar-derived CNS axon growth inhibitors: expression, receptor signaling, and correlation with axon regeneration
The Rho/ROCK pathway mediates neurite growth-inhibitory activity associated with the chondroitin sulfate proteoglycans of the CNS glial scar
Specificity of blebbistatin, an inhibitor of myosin II
Modulation of membrane traffic by mechanical stimuli
Laminin-2/integrin interactions enhance myelin membrane formation by oligodendrocytes
Identification of dystroglycan as a second laminin receptor in oligodendrocytes, with a role in myelination
Beta1-integrin signaling mediates premyelinating oligodendrocyte survival but is not required for CNS myelination and remyelination
Glutamate stimulates oligodendrocyte progenitor migration mediated via an alphav integrin/myelin proteolipid protein complex
Dominant-negative beta1 integrin mice have region-specific myelin defects accompanied by alterations in MAPK activity
Integrin-growth factor interactions as regulators of oligodendroglial development and function
Integrin-mediated axoglial interactions initiate myelination in the central nervous system
Fibronectin impedes "myelin" sheet-directed flow in oligodendrocytes: a role for a beta 1 integrin-mediated PKC signaling pathway in vesicular trafficking
Myosin II has distinct functions in PNS and CNS myelin sheath formation
Myelin impairs CNS remyelination by inhibiting oligodendrocyte precursor cell differentiation
Differentiation block of oligodendroglial progenitor cells as a cause for remyelination failure in chronic multiple sclerosis
Remyelination is extensive in a subset of multiple sclerosis patients
Enhancing central nervous system remyelination in multiple sclerosis
Premyelinating oligodendrocytes in chronic lesions of multiple sclerosis
An inhibitor of neurite outgrowth produced by astrocytes
Embryonic neurons adapt to the inhibitory proteoglycan aggrecan by increasing integrin expression


text:
Stranger Things is going down a storm with Netflix audiences, with the atmospheric 80s set show managing to really capture the style of the decade.
It does that in a number of ways including awesome production design and that delicious score by Kyle Dixon & Michael Stein and it also conjures up the era by liberally referencing other movies and shows from the time, and in some cases straight up borrowing elements or shots.
Here's a look at a few of the major influences.
Honestly, while I enjoyed Stranger Things well enough, particularly the early and later portions of the series, I'd go further to suggest that the show often bypasses homage and blatantly copies many of these other productions. In that way, it gets a bit of a free helping of nostalgia, which disguises how simplistic the show actually is.
Now that's just my opinion, but I'm still hoping that creators The Duffer Brothers manage to bring a little more originality to a proposed second series.
-Daniel Anderson


text:
Welcome to the New Social Area
Now that we are settled in to our new community home, I want to welcome you and point out a few changes to our policies.
The "no links" policy is a thing of the past. While we will not allow random, advertising, off-topic links, you are allowed to link to your photobucket, or other photo hosting account, and other links related to topics at hand.
As always, we will maintain a friendly, respectful community. Please know that there are always differences of opinion and that is what keeps life interesting. We are each responsible for exercising good manners and friendly interaction with our fellow members.
We will not tolerate copyright infringement. No published materials may be posted here unless you are the author.


text:
Teide Observatory
New Exchanges Policy for Volcano Teide activities
We have updated our Exchanges and Returns Policy to guarantee the best service and enjoyment of our activities. So, if you need to change or cancel your excursion or ticket, check the terms here!
Guided visits of the Teide Observatory with pick-ups from Puerto de la Cruz on Tuesdays
Today, we bring sensational news to those of you who visit Tenerife and stay in the northern area of the island, because from now on it is possible to visit the world's largest solar observatory with pick-up service from Puerto de la Cruz on Tuesdays.
- ← recent news
- previous news →


text:
Flipping Grub
The idea was to come up with a curly tail grub you could flip in heavy cover with out constantly losing tails to stem wrap. The tail is thicker and more tapered than the average grub, but still does move when falling. The body of the grub is wider along the horizontal axis to help with hook position on the hookset, and the flaps should help deflect the tail away from stems. This is the mold. See Flipping Grub 2 for an image of the bait. I'm debating making a tail mold for this bait. I may redo the mold though as the curve of the tail is not as smooth as I would like.
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text:
We have some nice deals on candy over at Target! That M&M's deal is a very nice one, so check it out.
At Target through 12/24:
BUY TWO MARS M&M'S CAFE MOCHA, MILK CHOCOLATE OR OTHER HOLIDAY VARIETIES (including 11.4 oz), on sale 2/$6
Use the 35% off M&M's Holiday Candies 8 oz or larger Target Cartwheel Offer (deducts $2.10)
and use one $1/2 Mars Products 2 oz or larger *including M&M's* printable coupon (preclipped)
NET PRICE FOR ALL: $2.90 (or $1.45 each!)
BUY TWO DOVE PEPPERMINT PROMISES 6-9.3 OZ OR OTHER HOLIDAY VARIETIES, on sale 2/$7
Use the 25% off Dove Chocolate Holiday Promises 7.94 oz or larger Target Cartwheel Offer (deducts $1.75)
and use one $1/2 Mars Products 2 oz or larger *including Dove* printable coupon (preclipped)
NET PRICE FOR ALL: $4.25 (or $2.12 each!)
Thanks Hip2Save.Extreme Couponing Tip: You can usually get two prints of most internet coupons. To find them in the easiest possible way, use our preclipped links that take you right to the coupon. Then come back and click the same link to get your 2nd print. This will save you the time spent searching for the coupon.
Never miss another hot coupon, deal or freebie again! "Like" Couponaholic .NET on Facebook, Follow us on Pinterest, Follow us on Twitter, Follow us on Instagram or Subscribe to our Daily Email Newsletter!


text:
Print advertisment created by Inbrax, Chile for Tramontina, within the category: House, Garden.
Chief Creative Director / Executive Creative Director: Pancho González
Creative Director: Fernando Cuevas
Art Directors: Cristián Chávez, Manuel Saballa
Copywriter: fernando cuevas
Client Team Director: Leandro Conzatti
Retouchers: Roberto Muñoz, Cristián Chávez
Account manager: Carolina Pinheiro
Highest Rated
I like it very much. It may be a little heavy-handed, but it is very effective for those who think about it a moment.
nice look. and something to think about - it even makes you wanting to think about it. but i see absolutely NO sense here.
The knife may be sharp, but the concept here is really a blunt one!
Love creating ads..
The concept is a knife so sharp and easy to use, you can slice things as thin as you like.
I like it very much. It may be a little heavy-handed, but it is very effective for those who think about it a moment.
Popular Reads
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text:
This property has been sold.Search for Available Property.
10 acres in Collin County, Texas
10 nice acres just .4 miles north of 160 near Blue Ridge and Trenton Texas. Property has nice trees, grass and a large stock tank. Would be a good property for building a home and/or a business. Has approx 375' of State Highway 121 frontage, so excellent visibility for a business. Has electricity run to the barn and water is at the street. Had a water meter at one time that still may be there. Nice rural setting, but still close enough to town to make shopping/dining convenient. Property is ag-exempt, so low property taxes.
From US 75 take SH 121 north 15 miles. Property will be on your left about .4 miles after you cross Hwy 160. Look for the red barn near the fence for a landmark. Property is 6 miles north of Blueridge and 3.75 miles south of Trenton.
Tax Data (Show Tax Data)
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Other Land for Sale in Collin County
- Properties for Sale in Nearby Counties
- Dallas County Land for Sale
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NOTE: The information contained herein is provided as general information only and has been obtained from sources deemed reliable. It is provided without any guaranty, warranty or representation, expressed or implied, made by Lands of America, or any related entity, as to the accuracy or completeness of the information. The information is presented subject to errors, omissions, change of price or conditions, prior sale or withdrawal without notice. Prospective purchasers should make their own investigations, projections and conclusions concerning the information.


text:
Flesh Collectors: Their Ghoulish Appetites Drove Them to Crimes that Only
Misfit Jeremiah Rodgers, 21, and racist devil worshipper Jonathan Lawrence, 23, were serving time for petty crimes when they met in a Florida penal system mental hospital. A friendship grew from their shared lust for sadistic brutality, and once released, they teamed up to hunt human prey. In March, 1998, in Pensacola, Florida, while quietly watching TV, Leighton Smitherman was shot in the back by assailants hiding outside his home. Amazingly, he survived, not knowing that he'd been chosen at random by would-be-thrill-killers. Their next target wasn't so lucky. Justin Livingston, 20, died from multiple stab wounds - some more than six inches deep. The horror peaked on 7 May 1999, when Rodgers went on a "date" with pretty Jennifer Robinson, 18, with Lawrence tagging along. The young woman was drugged and assaulted first by Rodgers, then Lawrence, before Rodgers shot her execution-style. But the worse was yet to come, an unspeakable act of mutilation that followed in the bloody footsteps of one of the most infamous serial killers of our time...
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text:
McCalls 3900 1973 Princess dress has back zipper. Long sleeved jacket has welts. Short sleeved buttoned jacket has fabric loops.
Links to reviews/blog posts Edit
Sources/Vendors Edit
finicky patterns UNCUT
Gallery Edit
[insert your photos of this pattern made up]
Wishlist Edit
[insert your username, and make sure your preferences allow for people to contact you via e-mail. Do not list your email address here!]


text: Celebrity Entertainment is proud to offer live entertainment and production for any type of occasion including corporate events, galas, cocktail parties, charities, fundraisers, and more. Our team has an incomparable ability to adapt the details to complement any occasion, age group, or clientele. All of our unique and quality services can be custom tailored to any type of event you have in mind!


text:
Catch up on Perks stock !
Discussion in 'Perky Pets Superstore' started by Perky Pets, 30 Oct 2014.
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text:
ATLANTA - A wide receiver named Johnson once summed up how to make him happy in a book title.
Give me the darn ball.
Only Keyshawn Johnson used a different adjective.
The same demand would be justified coming from Georgia Tech's Johnson. But Calvin Johnson shares little in common Keyshawn - aside from the ability to accumulate catches and yards the way Stephen Spielberg collects Oscar nominations.
Calvin Johnson isn't writing books or holding press conferences to complain about averaging less than five catches per game in his first two years with the Yellow Jackets.
"That's not me. I don't really worry about it," Johnson said. "All I can do is make plays when I get opportunities."
Still, coach Chan Gailey wants to get Johnson more chances. That's not easy given Johnson's position. Many already consider Johnson among the best offensive players ever at Georgia Tech, on par with Eddie Lee Ivery and Heisman Trophy finalist Joe Hamilton.
But unlike those two, Johnson can't touch the ball every down. Ivery averaged 24 carries per game in rushing for 1,562 yards in 1978. And Hamilton took nearly every snap in his 42 career starts between 1996 and 1999.
Somebody has to throw the ball to Johnson, and opponents can somewhat dictate his effectiveness with double and triple coverages and other gimmick defenses.
Handing Johnson the ball on trick plays is not a realistic option either. Gailey estimates he must call three fake reverses for every reverse Georgia Tech runs, which drains Johnson's energy.
Plus, the last time Gailey handed Johnson the ball - the 2004 Champs Sports Bowl - the star player sprained his knee and missed the rest of the game.
"You always try to put guys in position to excel and use the abilities they have," Gailey said. "I know what he is good at, and that's going down the field and catching balls."
To help Johnson, Gailey is moving the wide receiver around in pass formations and sending him in motion before the snap this spring. Johnson lined up in various spots last season - from close to the ball in the slot to near the sideline in multiple-receiver formations - yet still struggled to find creases in defensive secondaries.
Johnson said his route running is better now than last fall, particularly in the multiple sets. And he continues to mature physically. The 20-year-old is now 6-foot-4, 235 pounds, making him even tougher to cover.
The key to getting Johnson more touches lies as much with the quarterback as the coaches.
"Obviously things are set up to give him many more opportunities," Gailey said. "The key is to complete more of the things that are set up."
That hasn't happened much this spring, at least not between Johnson and starting quarterback Reggie Ball.
Ball strained a muscle in the opening days of spring practice. He practices but has yet to participate in scrimmages. The final scrimmage is set for 11 a.m. Saturday at Bobby Dodd Stadium.
Ball is a three-year starter, so missing spring practice should not be much of a setback.
And Johnson is content with his role. He said his lashing out following Georgia Tech's loss to Utah in the Emerald Bowl - "We didn't throw the ball," Johnson said after making two catches against the Utes - was an isolated incident, not a blanket indictment of the Ball, Gailey or the offense.
"That game was over with, and there wasn't anything I could do about it," Johnson said. "I was just frustrated."
The key this fall will be Georgia Tech's other receivers, Johnson said. Chris Dunlap has impressed the coaches this spring, and James Johnson is projected as the other starter at wide out despite missing practice time with a hamstring injury.
If they play well, defenses can't gang up on Calvin Johnson
"It's just a matter of them making plays and making it easier for everybody," Johnson said. "They do that, and I'll get the ball more too."
School: Georgia Tech
Hometown: Tyrone
Year: Junior
Position: Wide receiver
2005 statistics: 54 catches, 888 yards, 6 TDs
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text: This article is a stub. You can help The Monkees Wiki by expanding it. "Sunny Girlfriend"(Nesmith) Composer Michael Nesmith Producer Douglas Farthing Hatlelid Publisher Screen Gems–Columbia Music, Inc. Performance rights BMI Album Headquarters Retrieved from "http://monkees.wikia.com/wiki/Sunny_Girlfriend?oldid=4204" Ad blocker interference detected! Wikia is a free-to-use site that makes money from advertising. We have a modified experience for viewers using ad blockers Wikia is not accessible if you've made further modifications. Remove the custom ad blocker rule(s) and the page will load as expected. Categories: Article stubs Songs Monkees Songs Add category Cancel Save


text:
A developer of business management software.Speak with a ClearFactr provider
ClearFactr is the development company of ClearFactr software, an SaaS product combining a Self-Describing Spreadsheet, a powerful financial simulator, and a collaboration and sharing mechanism.
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text:
Game Description:
Download The Inquisitor - Book 1 for FREE! - Only best games at Sbenny.com
Play The Inquisitor - Book 1 game for free! You will love its gameplay for sure. Why paying for Google Play full versions? At our site you can download top mobile games for any smartphone or tablet easily and 100% free! With this apk game you will not be bored in your free time. If you install this full Android game, you'll play for hours and you'll surely have a lot of fun! Beautiful graphics and addictive gameplay will keep you captivated day and night. At our website you will find many other games or apps of different genres, from adventure and action to the rpg and racing apk games and you will also find mod and hacked version of every Android game: unlimited lives, ammo, levels unlocked, no ads and more!!! Download this great game for mobile phone via PC, Smartphone or Tablet!
Play a remorseless character to live an original story inspired by the famous novel of Valerio Evangelisti.
A will of steel, a heart of stone, intelligence as sharp as a knife, and wisdom as deep as oblivion. A host of divine weapons to fight Evil and heresy.
Eymerich is called upon to investigate an obscure case. Something that goes way beyond heresy, revealing a new face of Evil. He must tackle a great number of arduous tasks and make many painful choices. Terrible creatures await him, but with his burning determination he will overcome a Plague that is deadlier than his worst possible nightmare.
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text:
Did you know that there is a whole chain of islands off the coast of North Carolina? I did not, but apparently, one of these islands included Kitty Hawk, the famed site of the Wright Brothers' first flights. For thiese reasons alone, I had to go check out the area while I was in North Carolina, even if it meant driving almost 250 miles from Durham.
The drive, while pretty, could have been almost anywhere in the states that are reasonably green yet sunny. And the closer one gets to the coast, the more "minor" the highways get and the more they resemble back country roads. I took US-64 almost all the way to Kitty Hawk, and US-17 & 64 back.
Kitty Hawk did not disappoint. Or rather, the Wright Brothers Memorial on Kill Devil Hill (the name of a hill that used to be a sand dune), which I think technically is part of Kill Devil Hills (the name of the town directly south and right next to Kitty Hawk). Why Kitty Hawk and not Kill Devil Hills is frequently cited as the site of the Wright Brothers' first flights is beyond me, except that "Kitty Hawk" sounds infinitely more romantic and less satanic than the alternative. Anyhow, to see a life-size replica of Wilbur & Orville's first airplane (and one of their gliders), and to see exactly where they held their test flights was all-inspiring. So was reading about these two brothers who, by any measure, were true renaissance men. They changed the world and it is amazing just thinking about how our ability to easily travel almost anywhere afar was predicated off of their crazy obsession about humans flying aloft like the birds.
If you enjoyed this article, please consider receiving my weekly newsletter. I typically write about endurance bicycling, world travel, self improvement, Colorado living, marathon running, and epic adventures.
Articles related to Kitty Hawk, NC
- Other posts about North Carolina


text: 2.6K Views 2 7 Saved to Idea Box. OrganizeAll DIYHome Maint & RepairPlumbingPipes How to Locate Cables, Pipes and Studs behind a Wall Hometipster.com Hometalker Columbus, MS 2.6K Views 2 7 Saved to Idea Box. OrganizeLearn how to locate cables, pipes an studs behind walls before you start drilling with this handy diy security and safety guide. http://hometipster.com/how-to-locate-cables-and-pipes-behind-walls/ Hope you all find this guide useful.Got a question about this project?Featured SlideshowBe the Best Hostess on the Block With These 16 Home HacksView Slideshow 17Join the Conversation! 5 of 8 comments See Previous Add a CommentHometipster.com Columbus, MSHi Jeff. Glad you found the article interesting and helpful. Personally I would recommend anyone looking for a detector to go for a Multi-purpose one - they just save the need of having different ones in the toolbox. I won't specifically recommendBob Wichita, KSI just carry a couple of small magnets and find the fasteners that are in the studsTherese C Greenfield, IA@ Hometipster...you take on old plastic Bic razor and carefully remove the plastic protector edge below the blade, you then hold the razor by the end of the handle and drag the Bic over the wall. You can hear the definite sound difference when youHometipster.com Columbus, MSHi Bob - Never thought of that one and certainly a cheap alternative. Thanks for the tip.Hometipster.com Columbus, MSHi Therese, well it just goes to prove you can learn something new everyday. That's pretty amazing. Next time I'm definitely going to give that one a try.I have to say, that running hometipster.com and participating on sites like this is a joy - Inspired? Will you try this project? Let the author know!Visit URL: - ChangeRemoveDone Please enter a comment 2.6K Views 2 7 Saved to Idea Box. Organize


text:
Cars (2006)
Life is a journey. Enjoy the trip.
Rating: 7.4/10
Animation, Adventure, Comedy, Family, Sport,
Owen Wilson, Bonnie Hunt, Paul Newman,
Jumanji (1995)
A game for those who seek to find a way to leave their world behind.
Rating: 6.5/10
Adventure, Family, Fantasy, Thriller,
Robin Williams, Kirsten Dunst, Bonnie Hunt,
Only You (1994)
A love story written in the stars
Rating: 6.2/10
Comedy, Romance,
Marisa Tomei, Robert Downey Jr., Bonnie Hunt, Joaquim de Almeida, Fisher Stevens,
Beethoven (1992)
He'll grow on you.
Rating: 5.4/10
Comedy, Drama, Family,
Charles Grodin, Bonnie Hunt, Dean Jones, Nicholle Tom, Christopher Castile,
Cheaper by the Dozen 2 (2005)
This Christmas, you better watch out!
Rating: 5.3/10
Adventure, Comedy, Family,
Steve Martin, Eugene Levy, Bonnie Hunt, Tom Welling, Piper Perabo,
Hurricane Season (2009)
They Turned a Tragedy Into a Triumph.
Rating: 6.7/10
Drama, Sport,
Taraji P. Henson, Forest Whitaker, Bonnie Hunt, Khleo Thomas, China Anne McClain,
The Green Mile (1999)
Miracles do happen.
Rating: 8.5/10
Crime, Drama, Fantasy, Mystery,
Tom Hanks, David Morse, Michael Clarke Duncan, Bonnie Hunt, James Cromwell,


text:
Writings Pictures Anime Gaming About Links Blog Guests
Now We Are Twenty-Six
'Tis a sad poem to start what is actually a happy ramble, but I love T.S. Eliot's poetry, and I love poor old J. Alfred. And the truth is, I am too caught up in this stark world to attract the mermaid's song, even as young as I might be relatively speaking, but I will always continue to listen to their wail. I think both J. Alfred and the mermaids are lonely, and in a way they keep each other company.
Beautifully, today, I do not feel lonely, but I am in the mood for keeping mermaids company. (Whoah, that sounded suggestive! I meant to be poetic. Moving on...)
I am twenty-six today. Or perhaps sixteen-ten, I am not sure. If I were a Changeling, I'd be a Grump.
Quite frankly, I think that's silly. As Peter Pannish as I am, I think I've got quite a bit of Wilder in me left, thank you very much. I have two gray hairs and I refuse to let vanity pluck my hard-earned signs of wisdom out (because they'll just come back anyway... unlike wisdom, which can often fade unexpectedly). I think I have one for each year of grad school, so dammit, those hairs cost $32,000, and by golly I'm not throwing them away!
Ah, to hell with it. I do feel old. Which is utterly silly, because 26 is not old by any stretch of the imagination. I think the problem is I've been watching too much anime, where the veteran characters are usually no older than 23. (Yes, I've stopped spelling out ages. I can be inconsistent if I want.) But I feel old, I feel like I've done a lot, and maybe I feel a little bit tired.
But I also feel like there's still a hell of a lot ahead of me, and I feel like sometimes I can be wise auntie 'Becca (or Be-kaaaaaaa, as my niece pronounces it) and I can be a plump breasty Peter Pan and go flying once in awhile. Ah, the epiphany arises--I do not feel old, just in between. Too young to be old, and too old to be an anime character.
Enough of this silliness. HAPPY BIRTHDAY, EVERYONE! It is wonderful to be alive. I'm going to go to the mermaids now. Even if they won't sing to me, nothing's stopping me from singing to them.