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Republican lawmakers took another step Monday night towards reinstating the death penalty in New Mexico.
Members of the House Finance and Appropriations Committee voted 8-6 along party lines to send the capital punishment legislation to a vote of the full 70-member House of Representatives.
House Bill 7 would allow the death penalty in cases involving the murder of a child, a police officer or a corrections officer. The bill largely mirrors a capital punishment statute that legislators repealed in 2009.
As lawmakers wrangled with the bill and its potential costs, some committee members questioned the legislation's clarity and whether it could withstand court challenges.
"It doesn't feel like it was well thought out to me," said Rep. Doreen Gallegos, D-Las Cruces.
The co-sponsor, Rep. Monica Youngblood, R-Albuquerque, offered a dozen changes Monday night in response to criticism that the bill contained outdated language and other provisions that might be unconstitutional.
For example, the amendment replaced the term "mentally retarded," with "intellectual disability." But advocates for people with disabilities said Monday the legislation still might not stand up in court.
Youngblood's bill originally said inmates would be considered "retarded" if they have an IQ below 70. But in 2014, the U.S. Supreme Court prohibited using a specific IQ number to determine whether an inmate can be executed and required an individualized evaluation instead.
"The courts have made clear you have to dig a bit deeper," said Jim Jackson, chief executive officer of Disability Rights New Mexico.
His organization does not have a position on the death penalty but has raised concerns about how the proposed bill would be applied to people with disabilities. The group has argued, for example, that the bill does not have an adequate process to determine whether an inmate has a mental illness that might prohibit execution.
Youngblood's amendment also allowed the state to change the drugs it uses in executions. Rather than specifying the state would use an "ultra-short-acting barbiturate in combination with a chemical paralytic agent,' the amendment would only require a "substance" in "a quantity sufficient to cause death."
The change would allow the state to carry out an execution if the previously used drugs are no longer available. New Mexico Corrections Department procedures for execution include sodium pentothal, pancuronium bromide and potassium chloride - widely used among states with the death penalty. But some of those states have had difficulty obtaining those drugs in recent years as opponents of the death penalty have pressured manufacturers to stop selling them for use in executions.
Youngblood also proposed changing the bill to keep the identities of executioners confidential.
And in another change, Youngblood eliminated part of the process for determining whether a woman sentenced to death is pregnant. The bill Youngblood initially proposed with Rep. Andy Nunez, R-Hatch, called for doctors accompanied by a judge to examine the woman in a court.
"It's like we woke up in the 1950s," said Steven Allen, director of public policy for the American Civil Liberties Union of New Mexico.
Allen and many Democrats in the state House have argued the Legislature should not try to craft and pass death penalty legislation during a short special session but wait to take up the issue during the regular 60-day session starting in January.
"We are discussing a bill of life or death," Rep. Jeff Steinborn, D-Las Cruces, said during Monday's committee hearing. "This warrants extreme, intelligent, thorough deliberation."
But Youngblood and others supporting the bill have argued that much of the measure's language was tried and tested before the death penalty was repealed in 2009.
"This is a statute that worked in New Mexico previously," said Dianna Luce, district attorney of Lea, Chaves and Eddy counties. Luce said designing a totally new law would create "unknowns" in future appeals.
Typically concerned with the costs of legislation, the House Appropriations and Finance Committee spent much of its hearing grappling with differing calculations of the cost of reinstating capital punishment for a limited number of cases.
Attorneys from the Law Offices of the Public Defender said death penalty cases would strain defense lawyers and prosecutors alike while sapping even more resources from the state's courts. But prosecutors argued murder cases are already labor and resource intensive, suggesting the additional costs of death penalty cases would be insubstantial.
Legislative staffers wrote in a financial analysis that the bill would cost at least $2 million a year within the next 3 years. But Youngblood said the analysis inflated the costs based on a miscalculation of the number of cases in which the bill might apply. New Mexico used the death penalty sparingly when it was last in place, executing one man between 1977 and 2009.
The death penalty is 1 of 3 crime bills that Republican Gov. Susana Martinez added to the agenda of a special legislative session initially intended to address the state's budget deficit.
It could pass the Republican-controlled House on a party-line vote, but positions on the death penalty have not always been predictable. 3 sitting House Republicans voted to repeal the death penalty 7 years ago.
Unclear, too, is whether the state Senate will even consider the bill.
The Senate, where Democrats are the majority, adjourned Friday after passing several budget bills on the special session's 1st day, effectively snubbing the governor's tough-on-crime agenda.
Senators may have to return to Santa Fe later this week, however, to at least vote on changes to budget bills made by the House.
Death penalty bill will go to the House floor
The death penalty bill will go to the House floor after it barely made it out of the Finance Committee. Lawmakers Monday worked until 10 p.m. before voting 8 to 6 to advance the bill.
|Reinstating the death penalty could cost taxpayers an extra $1.5 million a year.
Committee members found themselves at odds over the price of the bill if it were to pass.
A legislative fiscal report that compiled data from each part of the criminal justice system found that on average, it could cost about $105,000 a year for one person in a death penalty case, and that about 14 cases could go to trial each year.
A legislative fiscal report that compiled data from each part of the criminal justice system found that on average, it could cost about $105,000 a year for one person in a death penalty case, and that about 14 cases could go to trial each year.
That means reinstating the death penalty could cost taxpayers an extra $1.5 million a year.
"Clearly all the fiscal analyses show that we can't afford this," said Christine Trujillo, a Democrat who represents Albuquerque. "It's a pure waste of time."
But the bill's sponsors defended the bill and refuted the numbers, saying lawyers won't always seek the death penalty.
"They're estimating they're going to have 14 trials for murder next year (but) they don't have any idea how many there are. That's just speculation," Republican Rep. Andy Nunez from Hatch said.
Nunez says he voted to repeal the death penalty back in 2009 but says now things have changed.
"You know the police officer who was killed in Hatch? I hired him, and he was shot down about 1,000 yards from my house," he said.
Trujillo and other Democrats say they understand this is an important, emotional issue, but urged people to wait until the regular legislative session convenes in January because this special session has cost taxpayers about $150,000 for the last 4 days.
"Let's stick to the budget," Trujillo said.
"We should be able to multitask," Nunez said.
The House is scheduled to reconvene Wednesday.
According to a recent poll by our partners at the Albuquerque Journal, 65 % of New Mexico voters support bringing the death penalty back
Source: KOAT news, October 4, 2016
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£425,000 Offers over
Charming detached cottage in an idyllic location with 4 acres of land and spectacular views.
Lounge I Conservatory I Dining Kitchen I Utility Room I 4 Bedrooms I En-Suite Shower Room I Shower Room I Sweeping Driveway I Triple Garage I 2 Summer Houses I Golf Practice Area I Hillside Vantage Point I Breath-Taking Views I Craighall Burn I 4 Acres of Land Including Paddock I EPC D
(4.00m x 4.40m / 13'1" x 14'5")
Living Room
(3.50m x 4.40m / 11'6" x 14'5")
(5.30m x 6.40m / 17'5" x 21'0")
Utility Room
(2.30m x 4.40m / 7'7" x 14'5")
(3.20m x 8.20m / 10'6" x 26'11")
Master Bedroom
(3.10m x 6.20m / 10'2" x 20'4")
(1.80m x 3.40m / 5'11" x 11'2")
Bedroom 2
(3.50m x 3.00m / 11'6" x 9'10")
Bedroom 3
(2.30m x 3.10m / 7'7" x 10'2")
Bedroom 4
(2.00m x 3.00m / 6'7" x 9'10")
Double Garage
(5.60m x 5.00m / 18'4" x 16'5")
(3.80m x 5.10m / 12'6" x 16'9")
This house description is based upon information supplied by the owner, or on behalf of the owner. These property particulars are produced in good faith and do not constitute or form part of any contract. s1homes do not take any responsibility for the accuracy of the information contained in this document.
If a property value displays '0', don't worry it just means no properties have been sold in that area during that time.
Sold house price data is supplied to us by the Registers of Scotland, a government department responsible for compiling and maintaining property registers, every month. There can be a delay of up to 3 months from when a property is sold to being recorded with Registers of Scotland. We provide house price data for your information only, we do not accept any liability for any errors. If you have noticed any incorrect information, please contact Registers of Scotland.

subset: commoncrawl


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B001UNME8C Used good or better, we ship best copy available! May have signs of use, may be ex library copy. Book Only. Expedited shipping is 2-6 business days after shipment, standard is 4-14 business days after shipment. Used items do not include access codes, cd's or other accessories, regardless of what is stated in item title. If you need to guarantee that these items are included, please purchase a brand new copy. Bookseller Inventory #
Title: KNOWING MACHINES Essays on Technical Change ...
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Like a mascara for your brows this light weight, tinted, brush on gel, subtly intensifies and volumizes your brows. Just one brush delivers a hint of pigment and flexible hold.
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Western Sales carries the following products. Select a manufacturer below to view the lines and collections carried by this retailer:
Simmons Bedding Company is the maker of Beautyrest, Beautyrest Black, Natural Care, ComforPedic and Simmons Kids mattresses, among others. Simmons ... See Simmons models »
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Western Sales is a home furnishings retailer based in Denver City, TX offering an array of mattresses alongside its other merchandise. Western Sales carries a variety of mattresses in its stores, including models from Simmons. Western Sales has a store location in Texas.
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VIDEO | Ultimate Insider Profiles The New Training Camp Of Tito Ortiz | UFC NEWS
http://youtu.be/LF95yh1SmB0 Former light heavyweight champion and UFC legend Tito Ortiz gave UFC Ultimate Insider a backstage pass into what his training camps are like. Correspondent Corissa Furr gets the grand tour of Ortiz's sick training compound in beautiful Bear Bear Lake. Read More: UFC (News), MMA (News), Tito Ortiz


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Chelsea romped to a 4-0 victory over host Thailand in the Premier League side's second friendly match in Asia Sunday at Bangkok's Rajamangala National Stadium.
Frank Lampard opened the scoring in the 37th minute with a long-range strike but Andre Villas-Boas' team appeared to wilt in the tropical heat as the game wore on.
Bolstered by the introduction of eight substitutes including Didier Drogba, Chelsea stretched its lead with second-half goals by Jose Bosingwa, Branislav Ivanovic and Florent Malouda.
Chelsea beat Malaysia 1-0 on Thursday and travels to Hong Kong to play Kitchee on Wednesday.
Topics : Football Liverpool Blackburn Rovers Chelsea Manchester United England Arsenal English Premier League Didier Drogba Frank Lampard Badminton Saina Nehwal
Get the latest Sri Lanka vs India 2017 news, check Sri Lanka vs India 2017 schedule and live score. Like us on Facebook or follow us on Twitter for more Sri Lanka vs India 2017 updates. You can also download the NDTV Cricket app for Android or iOS
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text:
- lighthearted
- adjective Date: 15th century 1. free from care, anxiety, or seriousness ; happy-go-lucky 2. cheerfully optimistic and hopeful ; easygoing • lightheartedly adverb • lightheartedness noun
New Collegiate Dictionary. 2001.
New Collegiate Dictionary. 2001.
lighthearted — cheerful, happy, *glad, joyful, joyous Analogous words: buoyant, resilient, volatile, effervescent, expansive (see ELASTIC): blithe, jocund, *merry, jolly: high spirited, *spirited: gay, sprightly, vivacious, *lively Antonyms: despondent… … New Dictionary of Synonyms
lighthearted — [adj] carefree, untroubled blithe, blithesome, bright, buoyant, cheerful, effervescent, expansive, feelgood*, frolicsome, gay, glad, gleeful, happy, happy go lucky*, highspirited, insouciant, jocund, jolly, jovial, joyful, joyous, laid back,… … New thesaurus
lighthearted — [līt′härt΄id] adj. free from care; cheerful lightheartedly adv. lightheartedness n … English World dictionary
lighthearted — adjective a) Joyful, glad, taking pleasure in being alive. Not depressed or sad. The lighthearted young lovers ran over the hills. b) Enjoyable lack of seriousness, not grave. His lighthearted banjo was appreciated because it relieved the tension … Wiktionary
lighthearted — light|heart|ed [ ,laıt hartəd ] adjective 1. ) happy and not worried about anything: a lighthearted attitude toward life 2. ) funny and not intended to be serious: a lighthearted look at the life of Shakespeare ╾ light|heart|ed|ness noun uncount … Usage of the words and phrases in modern English
lighthearted — adjective carefree and happy and lighthearted (Freq. 1) was loved for her blithe spirit a merry blithesome nature her lighthearted nature trilling songs with a lightsome heart • Syn: ↑blithe, ↑blithesome, ↑ … Useful english dictionary
lighthearted — lightheartedly, adv. lightheartedness, n. /luyt hahr tid/, adj. carefree; cheerful; gay: a lighthearted laugh. [1375 1425; late ME ligt herted; see LIGHT2, HEART, ED3] Syn. cheery, joyful, blithe, happy, glad, merry, jovial, jocund. Ant.… … Universalium
lighthearted — I (Roget s IV) modif. Syn. gay, joyous, cheerful; see happy 1 . II (Roget s 3 Superthesaurus) a. carefree, cheerful, happy, buoyant, sunny, jovial, playful, upbeat, blithe, glad, untroubled, joyous. ANT.: downhearted, heavyhearted, grave,… … English dictionary for students
lighthearted — humorous, joking His lighthearted approach to life is popular with students … English idioms
lighthearted — adjective a lighthearted musical Syn: carefree, cheerful, cheery, happy, merry, glad, playful, jolly, jovial, joyful, gleeful, ebullient, high spirited, lively, blithe, bright, sunny, buoyant, vivacious … Thesaurus of popular words
lighthearted — /ˈlaɪthatəd/ (say luythahtuhd) adjective carefree; cheerful: a lighthearted laugh. –lightheartedly, adverb –lightheartedness, noun … Australian English dictionary


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"Breaking Bad" is one of the highest rated crime drama TV series created by Vince Gilligan. It is story about Walter White (Bryan Cranston), a high school chemistry teacher diagnosed with lung cancer. Since his cancer did not seem to be cured, he decides to arrange money for his family future's before he dies using his chemistry knowledge. Due to which he started to prepare crystallized methamphetamine and sells it with help of his former student Jesse Pinkman(Aaron Paul). He gets deeply involved in meth business which turns him into drug kin ping named Heisenberg.
Continue reading Best Breaking Bad Quotes : 23 Walter White And Jesse Pinkman Quotes


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French Butterflies, collage art by Carol Engles
painting by artist Carol Engles
7 in X 5 in (17.8 cm X 12.7 cm)
mixed media collage on paper
This painting is available directly from the artist.
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text: WHY: The seat plate can break, posing a fall hazard to consumers.INCIDENTS: Sauder Woodworking Company has received 17 reports of seat plates breaking, two of which involved consumers falling and receiving bumps and bruises. HOW MANY: About 70,000 in the United States and 2,300 in Canada. FOR MORE: Contact Sauder Woodworking Company 888-800-4590 Monday through Friday between from 8 a.m. to 5 p.m. EST, or visit the firm's website at http://www.sauder.com .


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John Shalikashvili Dies
July 24, 2011 by staff
John Shalikashvili Dies, Retired Army General John Shalikashvili, who was the first foreign-born President of the Joint Chiefs of Staff to President Bill Clinton, died at a hospital in Washington State on Saturday. He was 75. Shalikashvili died at Madigan Army Medical Center in Tacoma, Washington on Saturday from complications of a stroke. A public memorial service will be held at the Tacoma Convention Center on August 6, followed by a funeral at Arlington National Cemetery at a later date.
Born in Poland in 1936, Shalikashvili raised from a U.S. Army recruit the chairman of the Joint Chiefs of Staff. He served as president from 1993 until his retirement in 1997 and was awarded the Presidential Medal of Freedom by former President Bill Clinton.
"Hillary and I are deeply saddened by the passing of our friend and colleague, General John Shalikashvili. He represented the U.S. at its best," Clinton said in a statement. "An immigrant who entered the army as a recruit, who became an outstanding chairman of the Joint Chiefs, who supervised more than forty operations, including the liberation of Haiti, a brutal dictatorship and the first use of NATO's force outside of its member countries in Bosnia. "
Shalikashvili praised Clinton for his "strong case" for the Bosnian people who said they saved thousands of lives in Bosnia. "It was also a key advocate for the reduction of nuclear weapons, NATO expansion, creating a partnership for peace and, always, for men and women in uniform from whose ranks came out," Clinton said. "I was honored to present the Presidential Medal of Freedom."
The former president said Shalikashvili will be remembered as a "general excellent and a wonderful man" who saw the world through some of the most critical moments of the late 20. "Our thoughts and prayers are with Joan and Brant," Clinton said, referring to his wife Joan and his son Brant Shalikashvili.
President Barack Obama also spoke about the death of Shalikashvhili, calling him a "true soldier and statesman, whose extraordinary life from the promise of America and the limitless possibilities that are open to those who choose their service."
"Since its arrival in the United States at 16 years old Polish immigrants after the Second World War, a young man who learned English from John Wayne movies, his ascent to the highest ranks of our military, life Shali was "only in the history of America," Obama said. "By any measure, that made our country safer and better."
Obama Shalikashvili acknowledged for his work as president, during which the strengthening of U.S. alliances in Europe and Asia, and closer defense ties with Russia. "At the same time, he successfully oversaw military operations in Bosnia and Haiti and elsewhere. Above all, he fought tirelessly to improve the quality of life of our soldiers, sailors, airmen, Marines and Coast Guardsmen and their families, which serve to keep us safe, "the president said.
Meanwhile, the U.S. Secretary of Defense, Leon Panetta, said he received the news of the death Shalikashvili with a heavy heart. "John was a remarkable patriot who faithfully defended this country for four decades to the very top of the military profession," said Panetta. "I lived the American dream, arriving from Europe with his family as a teenager after World War II, and dedicated his life to defending the country have quickly adopted him and his family."
Panetta, who served as head of the White House when he was president Shalikashvili said he trusted him for his wise counsel and his great military experience. "I will always remember John as being a staunch supporter of the brave men and women in uniform stand guard over this nation," said Panetta. "During my many years of public service, I have been privileged to serve with great leaders. John Shalikashvili was one of the best in this country."
Current Chairman of the Joint Chiefs, Admiral Mike Mullen, also mourned Shalikashvili. "We are a stronger, more capable military today because of their efforts to make us well. He will be sorely missed," said Mullen.
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On this page:
Draft a blueprint | Build for your users | Test what you've got | The paradox of choice | A sample menu
1. Draft a blueprint
When a new website gets the green light, the first response is often: "Great! Let's start writing." That can sometimes work, but it's usually a better idea to plan your site out first – laying down the structure before the content, just as you'd draw a floorplan before building a house.
To do this, you need a list of all the bits and pieces of content you'll want on your site: event listings, HR policies, lab opening hours – absolutely everything.
Depending on the size of the site you need, this can be a fair bit of work, but we promise: it's worth it. And if you skip this step, and build your site without a plan, there's a good chance it'll look a lot like a house built without a blueprint.
Architecture is hierarchical
To go back to our house analogy, you don't just throw a building together all at once. You need to follow a structural hierarchy: foundation first, then the supporting walls, and so on... Try building the roof before the walls, and you're going to have a bad day.
Similarly, once you know exactly what content will live on your site, you can start organizing it into a hierarchy called an "information architecture." For our purposes, that's just a fancy way of splitting your content into intuitive groups, sub-groups, sub-sub-groups and so on. These groups will become the sections, sub-sections, etc. of your site.
2. Build for your users (not for yourself)
Get to know your audiences
Before you build a site, you need to know who you're building it for. Who are your primary and secondary audiences? For large sites with multiple audiences, the audiences themselves can even provide the basis for your architecture's top level. For example, a typical faculty's website might have these sections:
About us | Prospective students | Current students | Research | News & events | Contact
Dividing your architecture by audience also gives you a chance to tweak your messaging for different people. For example, undergraduate and graduate students likely want different information, so they may appreciate an admissions-oriented site that triages them right away and addresses their individual needs separately. You may also want a more promotional tone for externally targeted content, and a more informational one for your internal audiences.
Learn how your users think
This might sound odd, but it isn't all that important that these groups make sense to you. What matters is that they make sense to your users. If they can't find your content, you may as well not be writing it.
For example, you may think about your faculty's services in terms of which unit provides them. That probably makes a lot of sense from, say, a budgetary perspective. But your student-heavy audience doesn't care which unit does what -- and if they have to go to each unit's section of the site to find a complete list of services available to them, they'll likely either get frustrated, give up, or both.
For a fresh perspective, you may want to run a quick card-sorting exercise. In a nutshell, you take your list of content, write each of those items onto an individual card, and ask a focus group of your audience members to sort them into piles and sub-piles that make sense to them. With a little finessing, those piles can then become the basis of your site's new architecture.
3. Test what you've got
If you're overhauling an existing site, consider running a usability survey to see how your audiences use it now, where the bottlenecks are, and what they'd like to see improved. Ask what they look for most, how easy it is to find, and how easily they can understand it once they've found it.
A word of caution: audience input is invaluable, but while your users generally have a good idea of what's broken, they don't always know how to fix it. Make sure common sense prevails -- and when in doubt, give us a ring!
4. The paradox of choice
For each menu, sub-menu, etc., aim for a maximum of six to eight menu items. Research shows that our brains can generally process roughly 7±2 items at once. More than that, and we tend to get confused, miss things, or forget the first few items by the time we get to the last ones.
In the same vein, site editors are sometimes tempted to plaster their pages with links, so that everything is just one click away. But the paradox of choice dictates that these overwhelming options can paralyze visitors, and make your site all but unnavigable. Imagine standing in a grocery aisle, staring at 50 brands of dish soap. Where do you start?
A good menu should answer that question for you: not by removing choices, but by organizing them in a way that makes sense. Say you're a student visiting the Faculty of Zoology's website, and you want a list of the faculty's academic advisors. A clear path might be:
Home page —> Services for students —> Academic advising —> Meet our advisors
That's just three clicks, and each time the user selects an option, his next step is clear. Now imagine navigating a menu like this one:
|Student services
|Staff directory
|International students
|Contact us
|About advising
|About us
|Undergraduate students
|Money matters
|More services
|What we do
|News & events
|Trouble with classes?
Granted, this second menu is terrible. But it illustrates the point: do you click on Advising, or Student Services? Staff directory, or Contact Us?
5. A (very simple) sample menu
If all goes well, your menu (or "information architecture") might look a bit like this when you're done:
Notice how, on this sample site, pathfinding is pretty simple. A Canadian grad student looking for information about courses has a clear path to his goal.
It's worth mentioning, too, that this is just a blueprint: a rough map of every page you plan to publish, and how they're organized in relation to each other. But like all our best-laid plans, this can (and should) shift and grow organically as needs change and new audiences arise.
Throughout that growth though, even as this blueprint goes more and more out of date over time, try to keep in mind the big-picture themes you used to build the site in the first place, and stick to them. This may help prevent what many McGill sites experience: a clear cut and fresh start, followed by months or years of unchecked growth in all directions. It isn't enough to build a site well; you've got to maintain it well too!


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Prices and availability are subject to change from the time and date that you print this page. 7/26/2017 7:26:46 AM.
For Customer Service, please call 800.933.9904.
WelcomeAmber JohnsonBaby, December 6, 2016 - Registry Number: 5535179
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Category: Print Template, Photoshop Template
GraphicRiver Real Estate & Travel Agency Business Flyer 4039664
Photoshop \ Print Template \ Flyers \ Commerce
Travel \ Business \ Professional \ Multipurpose \ Estate \ Included \ Agency
Print Template - Real Estate & Travel Agency Business Flyer 4039664 by HollyMolly @ GraphicRiver
Photoshop \ Print Template \ Flyers \ Commerce
A professional and multipurpose flyer, suitable for any kind of sales business like real estate agency, travel agencies or car dealers. Perfect catalog your products and increase your clients and exposure.
It comes with 2 different colors variations to better adapt to your business and 3 size options.
- Layered and fully editable.
- 300dpi – CMYK
- 2 color
- 4 sizes: Letter – A4 – A5 – A6
- Font: Raleway
- Photos not included
Logo not included, but you can make the download here
Layered: Yes; Graphics Files Included: Photoshop PSD; Minimum Adobe CS Version: CS3.
Hair Fashion Show Promotion Magazine Ad; Mardi Gras Crazy Circus Party Flyer; Romantic Valentine Night Party Flyer; Valentine Love Night Sessions Party Flyer; Web App Tech & Hosting Roll Up Banners; Hair Fashion Show Promotion Roll Up Banners; Valentine Day Party Flyer Bundle Pack.
Keywords: ad, advertising, agency, beauty center, blue, business, car dealer, catalog, clinic, commerce, corporate, creative, dynamic, elegant, exotic, fitness, green, gym, market, multipurpose, orange, professional, real estate, sales, services, travel, travel agencies.


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Webinar: When Do You Need a 510K?
Product ID: 702249
- Duration: 90 Min
Customer Care
Fax: +1-650-565-8542
Email: email@example.com
This 90-minute webinar will help you understand the 510K process including some history about 510ks versus PMAs and give you the necessary information to know when to file a 510k, as opposed to a PMA, or to not file any 510K of a new or existing medical device.
Why Should You Attend:
FDA is responsible for overseeing entry into the market of all medical devices. All devices, unless exempt, must go through a pre-market review for safety and efficacy. Anyone who wants to be a player in the medical device market must have a sound understanding of what is expected by FDA, and especially in the case of 510K clearance procedures he/she must know when it is or is not appropriate to submit a 510K for a medical device prior to marketing or during marketing due to changes in or to the device.
This knowledge is important to individuals involved because the penalties for a mistake range from a possible criminal prosecution of the "responsible" person(s) to a civil penalty, possibly up to $1,000,000, and/or FDA ordering a recall of the device if it is being marketed or filing a civil seizure lawsuit to have all the devices on the market seized by US Marshalls.
This 90-minute webinar will help you understand the 510K process including some history about 510ks versus PMAs. It will give you the necessary information to know when to file a 510k, as opposed to a PMA, or to not file any 510K of a new or existing medical device. We will also discuss what to do if the decision is to not file a 510K to satisfy the FDA when it conducts its next inspection.
Areas Covered in the Seminar:
- 510K submission.
- Premarket Approval submission.
- History of the 510k since it was initially created in 1976.
- When between a PMA and 510k, submitting a 510K is appropriate?
- PMA versus a 510K - time and cost factors.
- Failure to submit a 510K - individual(s) responsibility, corporate responsibility, criminal prosecution and penalties.
- Civil penalty, civil action and injunction action.
- When not to file a 510K in Class I and Class II devices.
- Managing FDA inspection when 510K is not files.
Who will Benefit:
This webinar will provide valuable assistance to all medical device companies/ manufacturing sites. Those that would benefit most would be:
- Technical Directors / VP's
- Product Development Managers
- Operations / Production Managers
- Compliance Directors/Managers
- Regulatory Affairs/ Quality
- Marketing
Charles R. (Bob) McConachie, is a Dallas, Tx attorney. He has practiced food and drug law beginning in 1970 at the Department of Justice where he litigated FDA enforcement and regulatory law cases in federal courts. From 1975 to 1979 he served as Chief of the Consumer Affairs Section, now the Consumer Protection Division of the Civil Division at DOJ. Among other cases he personally argued the case in which the FDA's decision to remove Red Dye No. 2 from the market by the end of the day was upheld by the DC Circuit.
In private practice since 1980 Mr. McConachie has advised food and drug clients on many aspects of food and drug law including compliance with FDA law and regulation of drugs, devices, food and food supplements. From 1982 until 2006 he served as an adjunct professor at SMU School of Law teaching the Food and Drug Law course. As a speaker Mr. McConachie has made presentations at FDLI and State Bar of Texas educational conferences on numerous occasions. Mr McConachie received the BBA degree from The University of Texas and the JD degree from St. Mary's University of San Antonio.
Refund Policy
Registrants may cancel up to two working days prior to the course start date and will receive a letter of credit to be used towards a future course up to one year from date of issuance. ComplianceOnline would process/provide refund if the Live Webinar has been cancelled. The attendee could choose between the recorded version of the webinar or refund for any cancelled webinar. Refunds will not be given to participants who do not show up for the webinar. On-Demand Recordings can be requested in exchange.
Webinar may be cancelled due to lack of enrolment or unavoidable factors. Registrants will be notified 24hours in advance if a cancellation occurs. Substitutions can happen any time.
If you have any concern about the content of the webinar and not satisfied please contact us at below email or by call mentioning your feedback for resolution of the matter.
We respect feedback/opinions of our customers which enables us to improve our products and services. To contact us please email firstname.lastname@example.com call +1-888-717-2436 (Toll Free).
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YSI pH Probes for Pro Series Portable Meters
Choose from lab-grade and field models.
Manufacturer: YSI 605101
SpecificationsDescription & Specifications
- For use with Pro Series Portable Meters
- Without cable
- Requires cable/probe assembly
|Pro series meter
|Without cable
|pH probe
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FoxFox Labs Mean Green Defense Spray- Flip Top Cone Fog (3 oz)
Fox Labs Pepper Spray is the hottest pepper spray used by Police and Military Worldwide now available to the public. Most pepper sprays are between 1/2 million to 2 million Scoville heat units; however, Fox Mean Green pepper spray is refined to 3 million Scoville heat units.
What is PEPPER SPRAY?
Pepper Spray is an inflammatory agent that works upon contact. It creates a very painful burning sensation in the eyes, nose, mouth, and throat; making it very difficult for someone who has been sprayed to do the simplest functions. Pepper Spray is a reasonable alternative to lethal force and will work better on individuals under the influence of drugs, alcohol, or who are mentally unstable.
"Every year nearly 5 million people are victims of violent crime; murder, rape, robberies or lifethreatening assault."- National Center of Policy Analysis
Protect yopurself they way law enforcement and the military do.
Available in Mean Green stream or cone fog models and in 1.5 oz or 3 oz sprays.
This is for a Mean Green Flip Top Cone Fog (3 oz)
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text: 1/26/12 12/04/11 POPSUGAR Celebrity Sarah Roemer Robert Pattinson With Sarah Roemer in LA Pictures Robert Pattinson Has a Late Night in LA With a New Lady December 4, 2011 by Lauren Turner 283 Shares Chat with us on Facebook Messenger. Learn what's trending across POPSUGAR. View on One Page Photo 10 of 10 Start Slideshow ADVERTISEMENT () Share This Link Copy ← Use Arrows Keys → 10 Sarah Roemer out with Robert Pattinson. Previous Next Sarah RoemerRobert Pattinson


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Providing a fair and efficient system of Justice | Search | Services Index | Change Font Size | Feedback | Contact
This packet is used to enforce all other portions of court orders or judgments except physical placement of a child. This packet is used only to enforce orders that have already been approved by court. If you would like to change a portion of an order, you may do so by using the Modification Packet.
The party requesting enforcement is required to properly notify the other party of the court date (see the Service Packet below).
Below you will find the Instructions and all the forms you will need to get from the beginning to the end of this court process. You have the option to:
Please keep in mind that not all forms are due at the same time. Review the Instructions (we recommend that you print it and keep it with your papers) to determine in what order to complete each form and other tasks required.
Hint: ONLY COMPLETE THE TASKS IN THE ORDER THEY ARE LISTED-Read ahead, but do not work ahead.


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Let your budding rugby player feel like a sports star in our 95 tee. Made from 100% cotton single jersey 180gsm, this crew neck tee shirt offers superior comfort for all day wear.
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Lattice Mixing and Vanishing Trapdoors: A Framework for Fully Secure Short Signatures and More
We propose a framework for adaptive security from hard random lattices in the standard model. Our approach borrows from the recent Agrawal-Boneh-Boyen families of lattices, which can admit reliable and punctured trapdoors, respectively used in reality and in simulation. We extend this idea to make the simulation trapdoors cancel not for a specific forgery but on a non-negligible subset of the possible challenges. Conceptually, we build a compactly representable, large family of input-dependent "mixture" lattices, set up with trapdoors that "vanish" for a secret subset which we hope the forger will target. Technically, we tweak the lattice structure to achieve "naturally nice" distributions for arbitrary choices of subset size. The framework is very general. Here we obtain fully secure signatures, and also IBE, that are compact, simple, and elegant.


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The Pink Panther 2
Blundering detective Clouseau is back in another antic-filled caper. This time, he joins a team of equally incompetent detectives to foil a thief from heisting historical artifacts. But is this bumbling crew able to keep up with their nimble quarry?
Rent DVDs for only $4.99 a month.
Movie Details
- Director
- Harald Zwart
- Genres
- Comedy, Action Comedies, Slapstick, Family Comedies, Ages 8-10, Ages 11-12
- Format
- DVD and Blu-ray
- Awards
- 2010 Razzie® Awards
- Worst Actor nominee: Steve Martin
- Ratings
PGSome suggestive humor, brief mild language and action
11Common Sense rating OK for kids 11+
DVD details
Blu-ray details
Widescreen 1.85:1Subtitles
English, Spanish (Neutral)Closed captioned
NoLanguage and sound
English: Dolby Digital 5.1, Spanish (Neutral): Dolby Digital 2.0 Surround, French: Dolby Digital 2.0 SurroundOther features
Color; interactive menus; scene access; gag reel; trailers.
Widescreen 1.85:1Subtitles
English, Spanish (Neutral), FrenchClosed captioned
NoLanguage and sound
English: DTS 5.1 HD, French: Dolby Digital 5.1, Spanish (Neutral): Dolby Digital 5.1Other features
Color; interactive menus; scene access; trailers; gag reel; making-of featurette; behind-the-scenes featurette.
The Pink Panther 2Close
For Parents
Common Sense Note
Parents need to know that this sequel to 2006's The Pink Panther is very similar to its predecessor. It's full of slapstick scenes involving pratfalls, wine bottles, cakes, fires, karate attacks, etc. There's one glimpse of a dead body, and a climactic scene features a gun-wielding criminal. Language is relatively mild -- mostly insults like "idiot" and "stupid" -- and sexual references are limited to a couple of on-going flirtations, allusions to relationships, and one celebratory kiss. Adults drink wine and cocktails.
- Sexual Content
- Flirting, a couple of dates, allusions to sexually attractive women, and one kiss.
- Violence
- Lots of slapstick violence; a restaurant burns down (twice); a dead man is shown (briefly); a character shoots a gun at a crowd.
- Language
- Mild insults like "idiot," "stupid," "French idiot," and "disgusting." Also "oh my God."
- Social Behavior
- The blissfully (or perhaps wilfully?) ignorant Clouseau makes potentially offensive comments, like calling a co-worker "sexy" or kids "piglets." But he's also a man of great loyalty to his country and his assignment to safeguard the Pink Panther. Jokes are made at the Pope's expense.
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- Products/brands featured or mentioned include Radio Shack, Smart Car, Range Rover, eBay, Mercedes, and CNN.
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- Age appropriate
- Not an issue
- Depends on your kid and your family
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Originally posted on Mets Merized Online | Last updated 10/31/12
Chase Headley of the San Diego Padres has won the National League Gold Glove Award at third base for the 2012 season. It's the first of Headley's career. Headley was voted the top defensive third baseman in the National League by managers and coaches. He was never really considered a solid defender at the hot corner, but this season he was a regular on Web Gems and turned in a National League leading .976 fielding percentage among all third basemen. It probably didn't hurt Headley's chances that he also had one of the best offensive seasons at third base, batting .286 with 31 home runs and a league leading 115 Runs Batted In. Even though offense shouldn't matter, I believe managers and coaches are still swayed by it. David Wright was also nominated along with Aramis Ramirez. It would have been nice to see Wright cop the award, but after a few disappointing defensive seasons leading up to 2012, I'm sure that came into play. Wright finished the season with a .974 fielding percentage a...
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Miami Prison Employee Pleads Guilty to Gay Sex With Inmates
In pornos, prison-guard-on-inmate sex makes for a reliable plot. In real life, it makes for a pretty serious crime. Just ask Jack Chris Jackson. The former employee at the Federal Correctional Institute in Miami pleaded guilty to having sex with numerous inmates and now could face up to 15 years in prison himself.
Jackson, 45, was a href="http://www.justice.gov/opa/pr/2011/September/11-crt-1164.html">indicted in September on charges of sexual abuse of an inmate (all sex between prison employees and inmates is legally considered abuse, even if it is consensual) and giving false statements. FCI is a medium-security prison that houses male inmates.
Jackson was questioned about carrying on a sexual relationship with an inmate in July, but he originally denied the charges. U.S. Department of Justice investigators pushed forward with the case anyway, and then also hit Jackson with charges of making false statements.
According to the Sun-Sentinel, Jackson pleaded guilty yesterday to carrying on the nearly year-long sexcapades with the inmate. He also admitted to having sex with a few other inmates at the prison.
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Prognostic value of α-fetoprotein and des-γ-carboxy prothrombin responses in patients with hepatocellular carcinoma treated with transarterial chemoembolization
Clinical and radiation oncology
Alpha-fetoprotein (AFP) and des-gamma-carboxy prothrombin (DCP) have been used as diagnostic tools for hepatocellular carcinoma (HCC). However, prediction of outcome using AFP and DCP has not been elucidated. We investigated the clinical role of AFP and DCP as predictors of treatment outcome in patients with HCC undergoing trans-arterial chemoembolization (TACE).
Between January 2003 and December 2005, we enrolled 115 treatment-naïve patients who received TACE as an initial treatment modality. An AFP or DCP response was defined as a reduction of more than 50% from the baseline level 1 month after TACE. Patients with AFP < 20 ng/mL or DCP < 20 mAU/mL were excluded.
The median age was 59 years and the male gender predominated (
AFP response and higher baseline DCP level are significant predictors of OS in treatment-naïve patients with HCC receiving TACE who showed pretreatment elevation of both AFP and DCP.
Hepatocellular carcinoma (HCC) is the third most common cause of cancer-related death globally
Alpha-fetoprotein (AFP) was first described about 40 years ago and is proposed as a screening and diagnostic tool for HCC
The primary aim of this study was to determine the clinical utility of AFP and DCP as predictors of treatment outcome in patients with HCC undergoing TACE.
Patients and methods
Between January 2003 and December 2005, a total of 270 patients underwent TACE as an initial treatment modality at Severance Hospital, Yonsei University College of Medicine, Seoul, Korea. Of these, we excluded 104 with an AFP level < 20 ng/mL
Diagnosis of HCC
HCC was diagnosed based on the guidelines of American Association for the Study of Liver Diseases
Treatment and response-evaluation protocols
After diagnosis of HCC was confirmed, angiography was performed to identify the major arterial supply to HCC. TACE was conducted using a solution of 20–50 mg doxorubicin hydrochloride in a 5–20 ml mixed solution of lipiodol and contrast agent. Subsequently, embolization was performed using gelatin sponge particles after TACE. After TACE, occlusion of target vessels and absence of additional tumor blood supply was confirmed.
Radiological response evaluation using CT or MRI and tumor marker response were evaluated 3–4 weeks after TACE. If viable tumor remained at CT or MRI, TACE was repeated. After 2–3 consecutive TACE sessions, at the time of best radiologic response, radiological and tumor marker responses were evaluated. If compact lipiodolization was noted and no viable HCC was identified, than radiologic evaluation and tumor marker measurement were done within 3 months to assess HCC recurrence. If progressive disease was identified, other treatment modalities were considered.
Tumor marker response evaluation
Baseline AFP and DCP levels were determined before TACE. Follow up tumor marker were checked every 3 ~ 4 weeks after TACE concurrent with CT or MRI. To analyze tumor marker response, we determined AFP and DCP levels when the best radiologic response was reached after 2–3 consecutive sessions of TACE. Tumor marker response evaluation was performed when complete remission is observed after consecutive session of TACE in most of subjects, but tumor marker response also analyzed within subject who did not get complete remission. In these patients, tumor marker checked just before last TACE concluded as progressive diseases by mRECIST criteria was used. AFP/DCP levels were measured using a microparticle enzyme immunoassay (AFP, Bayer, Leverkusen, Germany; DCP, Sanko Junyaku Co., Tokyo, Japan). AFP response was defined as a reduction in AFP level of more than 50% from baseline, according to a previous study
Radiologic response evaluation
Radiologic tumor response was evaluated using the WHO and modified RECIST criteria by CT or MRI. For the WHO criteria, minimum cross product was compared to baseline cross product for calculating change in size. Complete response (CR) was defined as complete disappearance; partial response (PR) was defined as 50% decrease; progressive disease (PD) was defined as a more than 25% increase in the cross product from maximum decrease. All other findings were defined as stable disease (SD). In the mRECIST criteria, length of the major axis of a viable tumor was compared to baseline for calculating change in size. CR was taken as the absence of any enhancing tissue, PR as a 30% decrease in enhancing tissue, and SD as a less than 20% decrease.
Calculation of progression-free and overall survival
The progression-free survival (PFS) time is defined as the time from the TACE start date to the first observation of tumor progression confirmed by mRECIST criteria or death due to any cause. To account for the fact that some patients dropped out for reasons other than tumor progression, PFS for these patients was censored at the time of last follow-up. The overall survival (OS) was calculated from the time of study entry to death. If the patient had no recorded date of death or was still alive at the time of the analysis, OS for these patients was censored at the date that the patient was last seen alive.
Statistical analysis
An independent
Baseline characteristics
Baseline characteristics of the 115 patients are described in Table
Tumor marker responses
After TACE, 91 (79.1%) patients showed AFP response and 24 (20.9%) were non-responders (Table
Objective responses after TACE and correlation with tumor marker responses
Independent predictors for PFS and OS
Univariate and multivariate analyses were used to identify independent predictors of PFS and OS (Table
Figure 1
Progression-free (PFS) and overall survival (OS) curves of AFP responder and non-responder.
Progression-free (PFS) and overall survival (OS) curves of AFP responder and non-responder. PFS was similar between AFP responders and non-responders (8.0
Figure 2
Progression-free survival (PFS) and overall survival (OS) curves of DCP responder and non-responder.
Progression-free survival (PFS) and overall survival (OS) curves of DCP responder and non-responder. Both PFS and OS were not significantly different between DCP responder and non-responder (7.8
DCP response within higher DCP levels
DCP response did not show statistical significance for prediction of PFS or OS after TACE. However, when we analyzed a subgroup of patients with a baseline DCP level > 200 mAU/ml
Combined serological endpoint
Sub-analysis was done to find out whether combined serological endpoint (AFP and/or DCP responses) would improve it prognostication
Discordance between cTM response and radiologic response
We divided the study population according to cTM and radiological responses. Definition of cTM response described at combined serological endpoint. Similarly, radiologic responders were defined as patients with CR/PR/SD and radiologic non-responders as those with PD using the mRECIST criteria. Using these definitions, eight (6.9%) cTM responders experienced a radiologic non-response and 12 (10.4%) cTM non-responders experienced radiologic responses; these were categorized as discordant.
Baseline albumin level was identified as an independent predictor of discordance between cTM response and radiologic response (HR, 2.747; 95% CI, 1.266–2.963;
Additional file 1
Table S1. Independent predictors between cTM responder with Radiologic non-responder (
Click here for file
Tumor response evaluation using CT or MRI after systemic chemotherapy or loco-regional treatment is widely used to decide whether to treat further or change treatment strategies. However, high cost, radiation hazard, and associated cancer risks are drawbacks to these response evaluation modalities,
This study also showed that AFP response can be an independent predictor of OS in patients undergoing TACE as the first treatment modality, whereas radiologic response was not significant in predicting PFS and OS. Several previous studies have also proposed the clinical usefulness of AFP response. Riaz et al.
The baseline AFP level in our study also showed statistical significance for predicting PFS in a multivariate analysis (
When we consider that only viable HCC can produce AFP and that the mRECIST criteria were developed to evaluate the amount of viable HCC, it is not surprising that AFP response showed a significant correlation to tumor response evaluated by mRECIST criteria. Although DCP is also produced by viable HCC, DCP response was not correlated with mRECIST response. This may be because, in contrast to AFP, DCP can be produced in surrounding non-cancer tissues after being stimulated by HCC
We further analyzed patients showing discordant outcomes assessed by cTM response and radiologic response, because in this situation physicians must decide whether to maintain the current treatment modality or change it. Although baseline albumin level was identified as a predictor of discordance between cTM response and radiologic response, there was no statistical difference in OS between cTM responders with radiologic non-response and those with cTM non-response but radiologic response (33.8
Interestingly, baseline GGT level was identified as an independent prognostic factor of PFS, similar to a recent study that proposed that GGT level is an important prognostic factor in patients with BCLC-intermediate HCC treated with TACE
This study has limitations. First, this was a retrospective study with a relatively small sample size. Also, some study subjects were included in article published recently and analyzed about prognostic value of AFP and DCP by the same institute
The present study demonstrated the clinical importance of AFP response and baseline DCP level for predicting OS in treatment-naïve patients with HCC undergoing TACE as an initial treatment modality. In the future, a treatment algorithm incorporating tumor marker response and radiologic response, which compensate for each other's drawbacks, should be established to more accurately predict treatment outcomes after TACE.
HCC: Hepatocellular carcinoma; TACE: Trans-arterial chemoembolization; BCLC: Barcelona clinic liver cancer; AFP: Alpha-fetoprotein; TTP: Time to progression; PFS: Progression free survival; OS: Overall survival; DCP: Des gamma carboxy prothrombin; WHO: World Health Organization; RECIST: Response evaluation criteria in solid tumor; mRECIST: Modified response evaluation criteria in solid tumor; CT: Computed tomography; MRI: Magnetic resonance image; CR: Complete remission; PR: Partial remission; PD: Progressive disease; SD: Stable disease; HR: Hazard ratio; CI: Confidence interval; GGT: Gamma glutamyltranspeptidase; HBV: Hepatitis B-virus; HCV: Hepatitis C-virus; ALT: Alanine aminotransferase; HBeAg: Hepatitis B e antigen; HBV-DNA: Hepatitis B virus-deoxyribonucleic acid; TNM: Tumor-Node-Metastasis; cTM: Combined tumor marker; LCSGJ: Liver cancer study group of Japan; ECOG PS: Eastern Cooperative Oncology Group performance status.
Competing interest
The authors declare that they have no competing interests.
Authors' contributions
Guarantor of the article: Jun Yong Park, MD, Specific author contributions: YKL and SUK organized the protocol, collected and analyzed the data, and prepared the manuscript. DYK, SHA, KHH, and CYC recruited the patients and assisted article preparation. DYL carried out transarterial chemoembolization in HCC. JYP had the original idea for the study, was involved in the study design, and assisted article preparation. All authors read and approved the final manuscript.
This work was supported by the grant of the Bilateral International Collaborative R&D Program from the Ministry of Knowledge Economy and by a grant of the Korea Healthcare technology R&D Project, Ministry of Health and Welfare, Republic of Korea (A102065).
Grant support
This study was supported by a grant of the Korea Healthcare technology R & D project, Ministry of Health and Welfare, Republic of Korea (A102065).
Trends in the leading causes of death in the United States, 1970-2002
How to predict HCC development in patients with chronic B viral liver disease?
Pilot clinical trial of localized concurrent chemoradiation therapy for locally advanced hepatocellular carcinoma with portal vein thrombosis
Hepatic arterial infusion chemotherapy using low-dose 5-fluorouracil and cisplatin for advanced hepatocellular carcinoma
Arterial embolisation or chemoembolisation versus symptomatic treatment in patients with unresectable hepatocellular carcinoma: a randomised controlled trial
Comparison of survival rates after bland arterial embolization and ablation versus surgical resection for treating solitary hepatocellular carcinoma up to 7 cm
Transcatheter arterial embolization with only particles for the treatment of unresectable hepatocellular carcinoma
Chemoembolization of hepatocellular carcinoma
Early-stage hepatocellular carcinoma: radiofrequency ablation combined with chemoembolization versus hepatectomy
Hepatocellular carcinoma presenting with bone metastasis: clinical characteristics and prognostic factors
Sorafenib in advanced hepatocellular carcinoma
Systematic review of randomized trials for unresectable hepatocellular carcinoma: Chemoembolization improves survival
Randomized controlled trial of transarterial lipiodol chemoembolization for unresectable hepatocellular carcinoma
Serum alphafetoprotein in hepatocellular carcinoma
Proceedings: Serum alphafetoprotein levels in liver disease: relation to hepatocellular regeneration and development of hepatoma
Early detection of hepatocellular carcinoma associated with cirrhosis by combined assay of des-gamma-carboxy prothrombin and alpha-fetoprotein: a prospective study
Prospective study of screening for hepatocellular carcinoma in Caucasian patients with cirrhosis
Serum alpha-fetoprotein for diagnosis of hepatocellular carcinoma in patients with chronic liver disease: influence of HBsAg and anti-HCV status
Efficacy of a surveillance program for early detection of hepatocellular carcinoma
NCCN clinical practice guidelines in oncology: hepatobiliary cancers
Resection of hepatocellular carcinoma without preoperative tumor biopsy
Accurate preoperative evaluation of liver mass lesions without fine-needle biopsy
New utility of an old marker: serial alpha-fetoprotein measurement in predicting radiologic response and survival of patients with hepatocellular carcinoma undergoing systemic chemotherapy
Serum alpha-fetoprotein response as a surrogate for clinical outcome in patients receiving systemic therapy for advanced hepatocellular carcinoma
Role of alpha-fetoprotein in hepatocellular carcinoma: prognostication, treatment monitoring or both?
Early alpha-fetoprotein response as a predictor for clinical outcome after localized concurrent chemoradiotherapy for advanced hepatocellular carcinoma
Alpha-fetoprotein response after locoregional therapy for hepatocellular carcinoma: oncologic marker of radiologic response, progression, and survival
Tumor markers in early diagnosis, follow-up and management of patients with hepatocellular carcinoma
Angiogenesis and hepatocellular carcinoma
Clinical utility of prothrombin induced by vitamin K absence in the detection of hepatocellular carcinoma in Indian population
Alpha-fetoprotein, des-gamma carboxyprothrombin, and lectin-bound alpha-fetoprotein in early hepatocellular carcinoma
Management of hepatocellular carcinoma
Combined measurement of preoperative alpha-fetoprotein and des-gamma-carboxy prothrombin predicts recurrence after curative resection in patients with hepatitis-B-related hepatocellular carcinoma
Computed tomography-an increasing source of radiation exposure
Prognostic values of alpha-fetoprotein and protein induced by vitamin K absence or antagonist-II in hepatitis B virus-related hepatocellular carcinoma: a prospective study
Early on-treatment predictions of clinical outcomes using AFP and DCP responses in patients with advanced hepatocellular carcinoma
Early alpha-fetoprotein response predicts treatment efficacy of antiangiogenic systemic therapy in patients with advanced hepatocellular carcinoma
An analysis of clinicopathological features and prognosis by comparing hepatoid adenocarcinoma of the stomach with AFP-producing gastric cancer
A new prognostic system for hepatocellular carcinoma: a retrospective study of 435 patients: the Cancer of the Liver Italian Program (CLIP) investigators
Clinical features and prognosis of hepatocellular carcinoma with reference to serum alpha-fetoprotein levels. Analysis of 606 patients
Time-dependent analysis of predisposing factors for the recurrence of hepatocellular carcinoma
Des-gamma-carboxy prothrombin in cancer and non-cancer liver tissue of patients with hepatocellular carcinoma
Prognostic significance of serum gamma-glutamyl transferase in patients with intermediate hepatocellular carcinoma treated with transcatheter arterial chemoembolization
Different mechanisms for gamma-glutamyltransferase-dependent resistance to carboplatin and cisplatin
Is serum gamma-glutamyltransferase inversely associated with serum antioxidants as a marker of oxidative stress?
Clinical characteristics and prognosis of hepatocellular carcinoma with different sets of serum AFP and PIVKA-II levels
Long-term outcome of transcatheter subsegmental and segmental arterial chemoemobolization using lipiodol for hepatocellular carcinoma
Pre-publication history
The pre-publication history for this paper can be accessed here:


text:
Whether you're rich or poor, famous or a regular joe, or somewhere in between, every person on this planet must at some point in their lives deal with stress and anxiety. Now I'm not saying that everyone has to act stressed out or anxious. I'm just pointing out that by living in this chaotic world, more often than not, disruption occurs between how life is and how each one of us thinks it should be.
In this recent Wales Online post, Rachel Mainwaring takes a look at how today more and more celebrities are falling from the spotlight grace due to mental and psychological issues caused by an inability to deal with overwhelming stress. Meditation expert Ivama Newman discusses the issue with Mainwaring, using the recent emotional breakdown of Catherine Zeta-Jones and stage fright confession of pop singer Adele as examples.
According to Newman, meditation helps us to find our inner peace. Moreover, meditation can help counteract the chemicals found in our brains that perpetuate feelings of stress and anxiety.
And with pop star Adele saying in an interview this week that she is too scared to perform on stage at festivals, as well as Catherine Zeta-Jones being treated recently for bipolar disorder following her husband Michael Douglas' cancer battle, Cardiff-based Ivama said meditation can be the key to helping combat nerves and depression.
She said: "For performers who get nervous, like Adele, meditation can certainly help. Those who practise it will find that the initial nervousness won't last quite as long. And it can certainly help those suffering from depression, as it can help regulate moods and counteract the chemicals in our brain that make people feel depressed.
Read more from Mainwaring and Newman on using meditation to deal with stress and anxiety here.


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|Biography Information
|Only known complete model of the Quadraxis-class robot
|Behind the Scenes
|Metroid Universe
The ultimate Luminoth combat mechanoid, Quadraxis is the guardian of the Hive Temple found in the depths of the Ing Hive. It's design is based on the Quad, but at a colossal scale. The Quadraxis battle is long and difficult, with there being up to four different phases in the battle.
Battle with SamusEdit
Quadraxis is first seen in the courtyard in front of the Sanctuary Fortress Temple, with various pieces of the robot strewn about the room. The actual fight takes place on the room's Dark Aether counterpart. Before the fight, the Quadraxis is inactive and standing in the center of the courtyard. Suddenly, Ing appear and infest the massive war machine. It becomes hostile due to being possessed and attacks Samus, who had barely walked twelve paces into the room.
In the first phase of the battle, Quadraxis attacks by sending shockwaves by stomping and by shooting energy bolts from its head. There are red-glowing antennae on its feet, which will cause Quadraxis to lose shielding on its legs and drop energy and missiles when hit two or three times with a ram from the Boost Ball. After it loses these, the knees become vulnerable to weapons fire and the robot begins to use its strongest weapon, a powerful Annihilator Beam shot. A knee becomes vulnerable when it is flashing blue, and powerful attacks like the Super Missile or Seeker Missile can easily destroy them in several shots. After losing the knees, the legs become useless and the main body slumps to the floor. The head abandons the crippled body, the latter aiding the former by broadcasting tactical data with a sonic transmitter. To sever connection between the head and the body, Samus must switch to the Echo Visor, which adds a sonic pulse to her beam shots in order to disable sonic security transmitters, and then fire at the transmitter until it retracts. Then the head will deploy three antennae in order to restore connection. These should also be attacked while using the Echo Visor. During this phase, the head will attack as long as it's connected to the transmitter, and will deploy Dark Quads to defend it when it loses connection. Once its three antennae are out, the Quadraxis goes mad and crashes into the body, shattering the shielding on its head and exposing two bomb slots. The surface of the exposed head is charged with magnetic energy, so Samus must use the Spider Ball to climb the magnetic rails on the crippled body and then use the Boost Ball to leap onto Quadraxis, then lay a Morph Ball Bomb in one of the slots and repeat. Even though it can't fight on its own now, it still deploys Dark Quads to help it. After bombing its head, the Quadraxis starts to explode, sending Samus flying and using her Gravity Boost to safely land nearby. Upon landing, she poses while the Quadraxis explodes behind her.
- It has been noted that the Crippled Head Module looks similar to an Aurora Unit, which could possibly mean that *Quadraxis was based on Mother Brain.
Wikitroid, the Metroid wiki.


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Spring Cleaning 15 Pack Mixed
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2011 Tied Knot Riesling
The 2010 vintage of the Tied Knot Riesling continues the winery's legacy of consistency. It's delicate, soft and notably approachable, but without sacrificing a certain special crispness. Our experts were most impressed by how nicely balanced they found this vintage, with a fruity conglomeration of Meyer lemon, pink grapefruit and peach being the catalyst in both the flavor and aroma of the wine. The Riesling grape varietal is an aromatic, dry white that evokes thoughts of flowers and perfumes. Originating from the Rhine region of Germany, it's considered amongst the three most important white wine varietals along with Chardonnay and Sauvignon blanc. Rieslings have a rich and storied history. The earliest known documentation of the wine being produced comes from Alsace in 1477 and by the late-nineteenth century, the grape made it's way to our shores.


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Running Time: 88 minutes
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text:
Many parents feel overwhelmed by the important task of parenting. As parents we want the very best for our children, but we often feel swamped by a sense of doubt and incompetence.
It is very strange that parenting is one of the most important responsibilities that we will be asked to take on in life, and yet we receive almost no training at all in the carrying out of this sacred responsibility. In school we receive instruction in many subjects that we will never need or apply in life after school, but receive little instruction in how to parent.
What were your parents like?
Usually the only way we learn about parenting is from the parenting we experienced at the hands of our own parents.
If we were fortunate and our parents did a good job, then our own parenting can be informed and enriched by what we experienced as children.
Unfortunately, if on the other hand our own childhoods were scarred by inept, indifferent or even abusive parenting, then we are likely to feel inadequate in our attempts to parent our own children. To our horror we may even find ourselves repeating some of the mistakes of our own parents. The emotional scars we carry from childhood can sometimes warp and inhibit our best efforts to be warm and wise parents.
Conflicting Advice
In desperation we might turn to books and DVDs about parenting, but then feel overwhelmed by all the advice and instruction contained in these resources, or confused by the conflicting advice from different sources.
There has been a tremendous amount of exploration and research into what makes effective parents over the last couple of decades.
From my own reading and experience this research can be basically boiled down to two main dimensions which if you can understand and apply will ensure that you manage to raise happy, well-adjusted, respectful, socially intelligent children. These two dimensions are:
1. Warmth; and
2. Structure.
To successfully apply these two dimensions, parents sometimes need some therapy themselves to help them heal from the wounds they carry from childhood.
Additionally, both parents need to be on the "same page", so as not to sabotage each other's parenting efforts.
If you are currently struggling to cope with some of the behaviour of your children, and feel that the above article speaks to some of your doubts and worries about your own parenting, please feel free to make an appointment to see me.
Matt Ryan is a senior psychologist with over 25 years of experience, and has seen great success in helping couples and families to work through their problems and difficulties.
To book an appointment with Matthew Ryan call 1800 877 924 or book online today!