text:
Specific NuRD components are required for fin regeneration in zebrafish
Epimorphic regeneration of a missing appendage in fish and urodele amphibians involves the creation of a blastema, a heterogeneous pool of progenitor cells underneath the wound epidermis. Current evidence indicates that the blastema arises by dedifferentiation of stump tissues in the vicinity of the amputation. In response to tissue loss, silenced developmental programs are reactivated to form a near-perfect copy of the missing body part. However, the importance of chromatin regulation during epimorphic regeneration remains poorly understood.
We found that specific components of the Nucleosome Remodeling and Deacetylase complex (NuRD) are required for fin regeneration in zebrafish. Transcripts of the chromatin remodeler
Altogether, our data suggest that specialized NuRD components are induced in the blastema during fin regeneration and are involved in blastema cell proliferation and redifferentiation of osteoblast precursor cells. These results provide
In contrast to mammals, some vertebrates such as urodeles and teleost fish benefit from exceptional regeneration mechanisms. Zebrafish are able to regenerate different organs after injury, including heart, fins, retina, liver, and spinal cord, and have become a powerful model organism for regenerative studies
The caudal fin of zebrafish is constituted of 16 to 18 bony fin rays (lepidotrichia), covered by an epidermis, and interconnected by soft inter-ray mesenchymal tissue
Upon amputation, the caudal fin is fully restored after approximately 3 weeks. This type of regeneration, called epimorphic regeneration, involves the formation of a blastema, a population of proliferating progenitor cells that arise from dedifferentiation of mesenchymal cells in the stump
The exact origin of blastema cells still remains unresolved. Recently, genetic cell-fate tracing studies have shown that the blastema is composed of a heterogeneous population of cells with restricted lineage fate and different tissue origin
Animals with robust regenerative capacities are characterized by their flexibility to change gene expression in response to amputation. This cellular plasticity allows temporal suppression of differentiation genes and reactivation of developmental signaling pathways, which are required for the reconstitution of lost tissues
Regulation of the chromatin structure is an important epigenetic mechanism, which has a direct influence on many biological processes. The Nucleosome Remodeling and Deacetylase (NuRD) complex is a multi-subunit complex widely expressed and evolutionarily conserved in animals and plants
The NuRD complex has been shown to play important developmental roles in cell fate determination
In this study, we investigated the potential role of the Mi-2/NuRD complex during fin regeneration in zebrafish. The zebrafish genome encodes several orthologs for every member of the vertebrate NuRD complex. However, we found that only one of each is expressed during fin regeneration. The orthologs of the NuRD components
One of the three Mi-2 orthologs,
Mi-2, which is the core ATPase of the NuRD complex, is essential for regeneration and neoblast differentiation in the planarian
Additional file 1: Figure S1
The genome of zebrafish encodes three Mi-2 orthologs. Figure S2. One of the three Mi-2 homologs,
Click here for file
To determine whether these putative Mi-2 orthologs might play a role in fin regeneration, we first examined their expression profiles during this process. Quantitative real-time-PCR (qRT-PCR) identified significant upregulation of
Figure 1
One of the three Mi-2 orthologs,
One of the three Mi-2 orthologs,
Early zebrafish larvae are also able to regenerate their caudal fin folds after amputation with a similar mechanism to that of regenerating adult caudal fins
Specific NuRD component orthologs are expressed in the blastema of regenerating fins
We then investigated whether other NuRD components are also expressed during fin regeneration. The genome of zebrafish encodes orthologs for all components of the vertebrate NuRD complex. BLAST searches identified three MTA orthologs, LOC794477 (
Figure 2
Specific NuRD component orthologs are expressed in the blastema of regenerating fins
Specific NuRD component orthologs are expressed in the blastema of regenerating fins. (A) Quantitative real-time-PCR analyses of
qRT-PCR data were confirmed by ISH on cryosections of adult caudal fins at 3 dpa. A single RNA antisense probe was designed for the two RBBP4/7 orthologs
Morpholino-mediated knockdown of
To determine whether these putative NuRD components play a role in fin regeneration, expression of
Figure 3
Morpholino-mediated knockdown of
Morpholino-mediated knockdown of
Specific HDAC1 inhibition affects regenerative outgrowth
To investigate the function of the histone deacetylase Hdac1 during fin regeneration, we used a pharmacological approach to target its activity. Hdac1 is the only HDAC1/2 ortholog encoded by the genome of zebrafish, and is required for development of the retina, the neural crest, and the central nervous system
Figure 4
Specific Hdac1 inhibition with MGCD0103 impairs fin regeneration
Specific Hdac1 inhibition with MGCD0103 impairs fin regeneration. (A) Western blot analysis for acetylation of histone H3 and histone H4 in 4 dpa fin regenerates treated with DMSO or 5 μM MGCD0103 starting from the time of amputation. The level of acetyl-H3 and acetyl-H4 in MGCD0103-treated fins was increased compared with DMSO-treated fins. β-actin and histone H3 were used as loading controls. (B-E) Whole caudal fins at 2 (B), 3 (C), 7 (D) and 10 dpa (E) treated with DMSO or 5 μM MGCD0103 starting from the time of amputation. MGCD0103 treatment for 10 days impaired regenerative growth without affecting the early stages of regeneration. Arrowheads indicate the amputation plane.
Interestingly, treatment of regenerating fins with 5 μM MGCD0103 for 10 days resulted in a substantial reduction in regenerative growth (Figure
To test whether MGCD0103 treatment is reversible, fish were exposed to MGCD0103 for 10 days from the time of amputation, and then transferred to normal water for 10 additional days. In general, fins failed to restart the initially blocked regenerative process properly, indicating that the effects of Hdac1 inhibition on caudal fin regeneration are irreversible (see Additional file
Taken together, these data indicate that MGCD0103-mediated inhibition of Hdac1 does not affect wound healing and initial blastema formation, but impairs progression of fin regeneration during the regenerative outgrowth phase.
The NuRD components
To understand the cause of the regenerative failure in fins deficient in these putative NuRD components, cell proliferation was assessed by labeling DNA-replicating cells with bromodeoxyuridine (BrdU) for 6 hours before fin collection. Because MGCD0103 treatment has the advantage of inhibiting Hdac1 from the time of amputation, cell proliferation was assessed in MGCD0103-treated fin regenerates during blastema formation and during regenerative outgrowth. At 2 dpa, mesenchymal cell proliferation was similar in DMSO-treated and in MGCD0103-treated fins, confirming that Hdac1 does not regulate blastema cell proliferation at this stage (Figure
Figure 5
The NuRD components
The NuRD components
MGCD0103 treatment resulted in a noticeable increase in wound epidermis (Figure
Depletion of the NuRD components
To examine the cellular consequences of NuRD component depletion, we assessed different cellular markers involved in fin regeneration. First, we examined mesenchymal reorganization by immunostaining with antibodies against Tenascin C, an extracellular matrix glycoprotein. Upon amputation, Tenascin C is rapidly induced in the mesenchyme below the amputation plane, and then expressed in the regenerating blastema
Figure 6
Hdac1 inhibition and morpholino-mediated knockdown of
Hdac1 inhibition and morpholino-mediated knockdown of
To evaluate the molecular specification of the blastema in fin regenerates deficient in NuRD components, we analyzed the expression of
Finally, we analyzed the expression of Actinodin 1, a marker for actinotrichia-forming cells
Hdac1 inhibition impairs osteoblast differentiation
To further investigate the effect of Hdac1 inhibition during regeneration of the bony rays, we examined the progression of osteoblast differentiation during regenerative outgrowth. Osteoblasts are specialized cells that line the bony rays and secrete bone matrix. Upon fin amputation, mature osteoblasts dedifferentiate, re-enter the cell cycle, migrate distally in the blastema, and, during regenerative outgrowth, redifferentiate into osteoblasts in lateral regions of the blastema
Figure 7
Hdac1 is essential for redifferentiation of osteoblast during regeneration
Hdac1 is essential for redifferentiation of osteoblast during regeneration. (A-B) Longitudinal sections of fin regenerates at 4 dpa treated with DMSO (A) or MGCD0103 (B) and triply stained with BrdU (green), ZNS5 antibody (red), and DAPI (blue). Dashed lines indicate the amputation plane. Proximal osteoblast nuclei acquired an elongated shape in control fins (A′), whereas osteoblast nuclei rarely presented an elongated shape in MGCD0103-treated fins (B′). (C) Percentage of ZNS5-positive cells at 4 dpa that were also positive for BrdU relative to the total number of ZNS5-positive cells in fin regenerates treated with DMSO or MGCD0103. Error bars represent the SEM. n = 15. *
Next we used transgenic fish lines expressing fluorescent proteins to examine the expression of the bone differentiation markers
The late bone differentiation marker
Hdac1 inhibition results in the upregulation of regeneration marker and two pluripotency-associated genes
In mammalian embryonic stem cells, the NuRD components HDAC1 and MBD3 have previously been shown to directly bind to and control the expression levels of pluripotency-associated factors
Figure 8
Hdac1 regulates the expression of two pluripotency-associated genes and regeneration marker genes
Hdac1 regulates the expression of two pluripotency-associated genes and regeneration marker genes. Quantitative real-time-PCR analyses of
Here we show evidence for the role of putative NuRD components during fin regeneration in zebrafish. We propose a model in which a specialized Mi-2/NuRD complex could be involved in blastema cell proliferation and redifferentiation during regenerative outgrowth. The zebrafish genome encodes orthologs for every subunit of the vertebrate NuRD complex. However, we found that transcripts of the putative NuRD components
We also found that disruption of these putative 'regenerating' NuRD components impaired fin regeneration. Chemical inhibition of Hdac1 by MGCD0103 and morpholino-mediated knockdown of
The wound epidermis was noticeably enlarged in
We found that on addition to the proliferation defects of blastema cells during regenerative outgrowth, Hdac1 inhibition and knockdown of
The effects of morpholino-mediated knockdown of the other NuRD components were not persistent, and regeneration resumed 48 hours post-injection. Morpholino injection has some limitations and is not an appropriate technique to analyze differentiation defects of bone-forming cells. Therefore, we were not able to analyze the consequences of morpholino-mediated knockdown of
Somewhat reminiscent to our findings in zebrafish, the planarian ortholog Smed-CHD4 is also essential for regeneration and neoblast differentiation in
Recently, an elegant model has been proposed in which the NuRD complex binds to the promoters of numerous pluripotency genes in embryonic stem cells (ESCs), probably to fine-tune the transcription levels of the genes and to maintain the differentiation responsiveness of the ESCs
We hypothesize that the Mi-2/NuRD complex might have a similar function during fin regeneration in zebrafish. This is suggested by our findings that the NuRD components were all expressed in the proliferative zone of the blastema during regenerative outgrowth and that their depletion resulted in a reduction in blastema proliferation and an increase in cellular differentiation defects. In addition, Hdac1 inhibition leads to the upregulation of the two pluripotency-associated genes,
Epigenetic mechanisms are critical for the regulation of gene expression and lineage specification during development
Our study provides further
The experimental animal research was approved by the cantonal veterinary office of Fribourg (Switzerland).
Zebrafish and fin amputation
The following zebrafish strains were used in this study: AB wild-type strain, and the
MGCD0103 treatment
MGCD0103 (Selleckchem, Houston, USA) was dissolved in DMSO at 10 mM stock concentration and then added to the fish water at a final concentration of 5 μM. 0.05% DMSO was added to the water of control fish.
Morpholino knockdown
The following antisense vivo-morpholinos (Gene Tools, OR, USA) were used:
where D is the area of the dorsal side and V is the area of the ventral side of the fin regenerate. Statistical significance was determined with the Student's t-test, and significance was set at
Fins were fixed in 4% paraformaldehyde in PBS, embedded in OCT, and cryosectioned. Antibody staining was performed as previously described
For proliferation assay, BrdU-positive cells distal to the amputation plane were counted in the mesenchyme and epidermis, and the number of BrdU-positive cells was normalized to the total number of DAPI-stained nuclei. Fluorescent pictures were taken with a confocal microscope (TCS SP5; Leica) and Image J 1.43q software was used for the measurements.
Quantitative real-time PCR
Fin regenerates were collected and total RNA was extracted using Qiazol (Qiagen, Basel, Switzerland). cDNA was synthesized using the QuantiTect Reverse Transcription Kit (Qiagen, Basel, Switzerland). Quantitative real-time PCR was performed in triplicate using the SensiMix SYBR No-ROX Kit (Bioline, Luckenwalde, Germany). Relative expression levels were normalized to
For MOSP efficacy, segments of the correctly spliced
prCP46: F TCCTTATCGTGACAGGCCTAC
prCP47: R GGAGTAGGGCCCTTTCAATC
prCP82: R AAGCAGACCATGTGATAGGC
Western blot
Fin regenerates were disrupted using glass beads in a mixture of 240 mM Tris HCl pH 6.8, 8% SDS, 40% glycerol, 0.01% bromophenol blue, and 1.4 M β-mercaptoethanol. Then 20 μg of total proteins were loaded per lane and separated by SDS-PAGE (12%). Even loading was verified by staining with Ponceau S and with β-actin antibodies (1:2000; Sigma). Proteins were transferred onto nitrocellulose membranes, and blots were incubated in 5% milk with rabbit anti-Histone H3 (1:2000), rabbit anti-acetyl-histone H3 (1:1000), anti-acetyl-histone H4 (1:1000) (all Millipore) and β-actin (1:2000; Sigma). Secondary HRP anti-rabbit and anti-mouse antibodies (Sigma) were used at 1:10,000.
And1: Actinodin 1; BrdU: 5-bromo-2′-deoxyuridine; DAPI: 4′,6-diamidino-2-phenylindole; DMSO: Dimethyl sulfoxide; dpa: Day post-amputation; hpa: Hour post-amputation; MO: Vivo-morpholino; MOSP: Splice blocking vivo-morpholino; MOTL: Translational blocking vivo-morpholino; qRT-PCR: quantitative real-time polymerase chain reaction; TenC: Tenascin C.
Competing interests
The authors declare no competing interests.
Authors' contributions
FM, CW, and AJ conceived and planned the study. CP performed the experiments. CP, FM, CW, and AJ wrote the manuscript. All the authors discussed the results and commented on the manuscript. All authors read and approved the final manuscript.
We are grateful to Franscesco Hofmann, Novartis Pharma AG for providing the NPV-AEW541 compounds, to Claire Jacob for providing the MGCD0103 compound, and to Gilbert Weidinger for providing the transgenic fish. We thank V. Zimmerman for excellent fish care; S. Käser-Pébernard for critical reading of the manuscript; and Y. Molleyres and L. Bulliard for excellent technical help. This work was funded by the Swiss National Funds grants 31003A_125577 of F. M. and C. W. and 310030_138062 of A. J.
Axonal regrowth after spinal cord transection in adult zebrafish
Increased expression of specific recognition molecules by retinal ganglion cells and by optic pathway glia accompanies the successful regeneration of retinal axons in adult zebrafish
Heart regeneration in zebrafish
Tales of regeneration in zebrafish
Liver growth in the embryo and during liver regeneration in zebrafish requires the cell cycle regulator, uhrf1
Old questions, new tools, and some answers to the mystery of fin regeneration
Conserved mechanisms regulate outgrowth in zebrafish fins
Stem cells in animal models of regeneration
A proliferation gradient between proximal and msxb-expressing distal blastema directs zebrafish fin regeneration
Osteoblast maturation occurs in overlapping proximal-distal compartments during fin regeneration in zebrafish
Maintenance of blastemal proliferation by functionally diverse epidermis in regenerating zebrafish fins
Bone regenerates via dedifferentiation of osteoblasts in the zebrafish fin
Cells keep a memory of their tissue origin during axolotl limb regeneration
Fate restriction in the growing and regenerating zebrafish fin
Regeneration of amputated zebrafish fin rays from de novo osteoblasts
IGF signaling between blastema and wound epidermis is required for fin regeneration
Notch signaling coordinates cellular proliferation with differentiation during zebrafish fin regeneration
Activin-betaA signaling is required for zebrafish fin regeneration
Fgf signaling instructs position-dependent growth rate during zebrafish fin regeneration
Notch regulates blastema proliferation and prevents differentiation during adult zebrafish fin regeneration
Roles for Fgf signaling during zebrafish fin regeneration
Induction of lef1 during zebrafish fin regeneration
Inhibition of BMP signaling during zebrafish fin regeneration disrupts fin growth and scleroblasts differentiation and function
Distinct Wnt signaling pathways have opposing roles in appendage regeneration
High-efficiency gene transfer into adult fish: a new tool to study fin regeneration
Inhibition of zebrafish fin regeneration using in vivo electroporation of morpholinos against fgfr1 and msxb
A zebrafish retinoic acid receptor expressed in the regenerating caudal fin
fgf20 is essential for initiating zebrafish fin regeneration
The human Mi-2/NuRD complex and gene regulation
Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex
Mi-2 complex couples DNA methylation to chromatin remodelling and histone deacetylation
NURD, a novel complex with both ATP-dependent chromatin-remodeling and histone deacetylase activities
The dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activities
The NuRD architecture
Mi-2/NuRD: multiple complexes for many purposes
The C. elegans Mi-2 chromatin-remodelling proteins function in vulval cell fate determination
MEP-1 and a homolog of the NURD complex component Mi-2 act together to maintain germline-soma distinctions in C. elegans
dMi-2, a hunchback-interacting protein that functions in polycomb repression
The role of the chromatin remodeler Mi-2beta in hematopoietic stem cell self-renewal and multilineage differentiation
The NuRD component Mbd3 is required for pluripotency of embryonic stem cells
The Mi-2-like Smed-CHD4 gene is required for stem cell differentiation in the planarian Schmidtea mediterranea
Caenorhabditis elegans APN-1 plays a vital role in maintaining genome stability
Early fin primordia of zebrafish larvae regenerate by a similar growth control mechanism with adult regeneration
Gene expression and functional analysis of zebrafish larval fin fold regeneration
Histone deacetylase 1 is required for cell cycle exit and differentiation in the zebrafish retina
Zebrafish colgate/hdac1 functions in the non-canonical Wnt pathway during axial extension and in Wnt-independent branchiomotor neuron migration
Distinct functional and temporal requirements for zebrafish Hdac1 during neural crest-derived craniofacial and peripheral neuron development
Histone deacetylase 1 regulates retinal neurogenesis in zebrafish by suppressing Wnt and Notch signaling pathways
The epigenetic regulator Histone Deacetylase 1 promotes transcription of a core neurogenic programme in zebrafish embryos
Histone deacetylase 1 is required to repress Notch target gene expression during zebrafish neurogenesis and to maintain the production of motoneurones in response to hedgehog signalling
MGCD0103, a novel isotype-selective histone deacetylase inhibitor, has broad spectrum antitumor activity in vitro and in vivo
Determination of the class and isoform selectivity of small-molecule histone deacetylase inhibitors
Loss of fish actinotrichia proteins and the fin-to-limb transition
Tail fin regeneration in teleosts: cell-extracellular matrix interaction in blastemal differentiation
Actinotrichia collagens and their role in fin formation
Differentiated skeletal cells contribute to blastema formation during zebrafish fin regeneration
Temperature-sensitive mutations that cause stage-specific defects in Zebrafish fin regeneration
HDAC1 regulates pluripotency and lineage specific transcriptional networks in embryonic and trophoblast stem cells
NuRD suppresses pluripotency gene expression to promote transcriptional heterogeneity and lineage commitment
Phosphorylation of Junb family proteins by the Jun N-terminal kinase supports tissue regeneration in zebrafish
Upregulation of cathepsin D expression in the dedifferentiating salamander limb regenerates and enhancement of its expression by retinoic acid
Comparative expression profiling reveals an essential role for raldh2 in epimorphic regeneration
CCAAT enhancer- binding protein beta is required for normal hepatocyte proliferation in mice after partial hepatectomy
The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men
Transcriptional repressors: multifaceted regulators of gene expression
Epigenetic mechanisms that regulate cell identity
A histone demethylase is necessary for regeneration in zebrafish
Retinoic acid and Cyp26b1 are critical regulators of osteogenesis in the axial skeleton
Gene expression analysis on sections of zebrafish regenerating fins reveals limitations in the whole-mount in situ hybridization method


text:
Too often in critical situations, communications among public safety agencies are hampered by interoperability problems. These incompatibilities are largely due to a lack of standards for a common approach to public safety communications.
Our PSCR laboratories provide research, development, testing, and evaluation to foster nationwide communications interoperability. Drawing on critical requirements provided by public safety practitioners, the PSCR program provides insight to wireline and wireless standards committees developing standards for voice, data, image, and video communications.
Housed within the Department of Commerce Labs in Boulder, Colorado, the PSCR program is a joint effort between NIST CTL and NTIA ITS. The very successful research performance of the joint effort has earned two Department of Commerce Gold Medal awards, the highest honor granted by the Department, as well as two Silver and two Bronze Medal awards.
The PSCR program performs research on behalf of our sponsors at DHS OIC, DHS OEC, and NTIA FirstNet to advance public safety communications interoperability.
We involve public safety practitioners — fire, police, and EMS — directly in our research and development activities for public safety specific requirements.
PSCR program project results are disseminated regularly to the public safety community through applicable conferences such as the Association of Public-Safety Communications Officials — International, the International Wireless Communications Expo, articles, reports and documents, and outreach events.

subset: commoncrawl


text:
performance auditnoun [ C ]uk us
› HR an examination of the methods and processes used by an organization to check that it is working effectively:
They are working to correct operational shortcomings found in a performance audit two years ago.
(Definition of "performance audit" from the Cambridge Business English Dictionary © Cambridge University Press)
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friendly and pleasant to be with


text:
The snow in Baltimore last week. The tornadoes in Chicago on Nov. 17. The lightning Denver on opening night.
When it comes to weather, the Ravens have seen it all. So no one around the Under Armour Performance Center is complaining about the fact that they won't have to worry about the elements Monday night in Detroit.
The Ravens get a respite from the cold and strange conditions when they play under the dome at Ford Field. (But it's worth reminding everyone that the team did experience a blackout the last time it played indoors, at the Superdome in New Orleans in February's Super Bowl.)
"I'm actually thrilled about it, I'm not going to lie," cornerback Jimmy Smith said. "Being inside on the fast turf, no weather - it's going to be perfect for both teams, so both teams should be at their best. ...
"Inside, it's perfect weather. There's no excuse. I honestly kind of like the fact that we get to play in the elements, because you get to see what other teams are really made of that are indoors all the time."
Quarterback Joe Flacco is also looking forward to it.
"I never make a big deal about playing outside, but every time you go into a dome and you start warming up, you realize how awesome it is to be able to throw the ball inside," he said. "It won't have too much of an effect on the outcome of the game. As a quarterback, you always want great conditions, and a dome obviously presents that, but we're still going to have to go play fundamental football and take care of business."
The Lions are used to playing on the turf field indoors while the Ravens are not. Plus, Baltimore has struggled mightily on the road this year - something the team will need to change down the stretch with two of its last three games away from M&T Bank Stadium.
The Ravens are 6-1 at home, but 1-5 on the road.
"We've won the close games at home, and we haven't won them on the road. That's the bottom line," coach John Harbaugh said. "We've done the things we needed to do to win tight games at home, and we haven't done the things we needed to do on the road. It's us - it's what we've done - the plays we've made or haven't made that have been the difference."
In Baltimore, the Ravens are 4-1 in games decided by eight points or fewer. They're 1-4 in such contests on the road.
At 7-6, the Ravens are in a different spot than they were a year ago when starting 9-2 before skidding to the finish. This year, they need to win just to make the playoffs, and that includes Monday at Detroit.
The Ravens currently hold the AFC's second wild card with three weeks to go. But the Dolphins are also 7-6 with two games against sub-.500 teams in their last three. Baltimore plays three division-leading clubs to finish the regular season.
"The mentality's different because we have to win. We have no other option. It's, at this point, win or go home for us," tight end Dennis Pitta said. "So we have to treat every game like it's a postseason game because we don't have any more opportunities. Last year, I think we got out to a great start and we let ourselves relax a little bit and had a three-game slide, and then refocused and really got hot for a playoff run. So this year, the mentality is different because we lost some tough games early on and some close ones, and now we have to be able to put it together to get in the postseason."
Lately, that desperation has brought out the best in the Ravens, who have won three straight and four of five.
"I think you find out a lot about your team and yourself when your back's against the wall a little bit, and this team continues to respond in difficult situations," Pitta said. "We know that we play good football in December. That's what we're built to do and that's what we have to continue to do if we want to have success this year."
To keep that going, the Ravens will have to overcome the hostile environment of a noisy dome instead of unique weather.
"It's going to be a big challenge. I don't think indoor-outdoor means much for us; it won't matter," Harbaugh said. "We've been in weather. I don't think we've been in a dome yet, that I recall. The crowd noise is going to be a factor. It's Monday Night Football, it's going to be loud, it's a hugely important game for both teams, it's a great place to play, and it's going to be a huge challenge for us.
"It literally is going to be the Lions' den. It's their den, and they're very good at home, so it's going to be tough. We've got to be ready. We've got to be at our best. We'll have to play the best we've played all year."


text:
Dustin Diamond Is Sorry for What He Did to His 'Saved by the Bell' Co-Stars
It's never too late to say sorry. More »
It's never too late to say sorry. More »
It was only eight months ago that Lark Voorhies' bizarre behavior was the focus of media attention, not Amanda Bynes.
For those of you who need a reminder, Lark (fondly remembered as Lisa Turtle) grew up on the small screen as a cast member on the hit series Saved By The Bell. And while most of the… More »


text:
Byron Energy Limited has set 5 ½ inch intermediate casing to a depth of 7,861 feet (2,396 metres) measured depth ('MD') and 7,751 feet (2,363 metres) true vertical depth ('TVD') in the Byron Energy SM 6 #1 BP02 ('SM 6 #1 BP02'). At 5 pm 17 July 2014 (USA central time) cementing operations have been completed.
The memory log data has been retrieved from the Log While Drilling ('LWD') tool and is a substantial improvement in quality over the real time logs, the results of which were reported in the ASX release dated 16 July 2014.
The LWD memory log data shows that there are several thin hydrocarbon bearing F 30 Sand lobes over a 84 foot (26 metre) gross interval between 7,110 to 7,194 feet (2,167 to 2,193 metres) MD and 7,053 to 7,131 feet (2,150 to 2,174 metres) TVD.
Byron Energy Limited
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Still need some help!
Filed Under (NL East Chatter) by mrose at 9:27 AM on 04-26-2011
With the regular season underway, we here at NLEC and our family of blogs are still a bit under staffed (except Real Dirty Mets). We are in need of additional Philllies Bloggers at Phillies Phandom, more Nats bloggers at Centerfield Gate and some dedicated individuals to start their own Braves and Marlins blogs. All the while, if you want to write about the NL East in general, we need help at the parent site here, at NL East chatter.
For any of the above, please contact email@example.com
Please visit Real Dirty Mets for all your Mets News, CenterfieldGate for all Nats, and finally, Phillies Phandom to find out how the NL Favorites are fairing.
Thanks for the continued support of this project!


text:
To the Editor.—
Recently, Sandoz, Ine (East Hanover, NJ) produced an advertisement entitled "Sandoz Answers Common Questions About: Tardive Dyskinesia: Are Some Neuroleptics Less Likely to Cause It?"This advertisement is a prime example of how unscientific assertions and conclusions result in a misleading promotion of a useful drug. From the outset, this advertisement claims that thioridazine (Mellaril) is a site-specific, low-potency antipsychotic that has little effect on extrapyramidal dopamine receptors and therefore is less likely to cause long-term movement disorders, specifically tardive dyskinesia (TD). This alluring categorization of thioridazine is belied by the fact that there are no substantive research data or even supportive clinical data that thioridazine is any less likely to cause TD than any other neuroleptic. On the contrary, there are verified cases of thioridazine-induced TD that indicate that, like all neuroleptics, thioridazine can cause TD. Having carefully reviewed and assessed the statements in each paragraph
Ayd FJ, Coyle JT, Hollister LE, Simpson GM. Tardive Dyskinesia and Thioridazine. Arch Gen Psychiatry. 1984;41(4):414-415. doi:10.1001/archpsyc.1984.01790150104015
© 2017


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Pharmacist - A Job Option | Career in PharmacyBY: Amna Adnan | Category: Careers | Submitted: 2010-08-24 23:05:56
Article Summary: "A pharmacist is a health practitioner who helps patients and doctors to understand drugs. There are good jobs for them with very high salary..."
A pharmacist is a health practitioner who dispenses drugs prescribed by the doctors. He has the knowledge of medicine and pharmacy together to give information to his customers about the medicines and against which disease they are used, also their side affects and hazards. He has also has full knowledge of using the computer and keeps records of the drugs which patients use and he also keeps medical profiles of the patients so that patient does not get confused in using the drug and does not combine one drug with the other. It is the duty of the pharmacist to get involved with the patient and make him understand the prescriptions and also with the practitioners to help them in prescribing the right drug.
To become a pharmacist, it is necessary for an individual to have six years of education along with high school education. When the students complete their school degree, they start a four year program which results in the degree of pharmacy. To enter in the degree of pharmacy there are some basic requirements of the courses like natural and social sciences, and mathematics. Almost all the colleges take pharmacy tests before giving admission to the students. It is also encouraged if the students want to pursue their studies and want to get Master's or Doctorate degree.
When the training of a pharmacist starts, before that the students should have a degree in Pharm. D from a recognized college. In this degree, students are taught about different drugs, drug therapies and most of all they are taught that how to communicate with the people and how to make them understand about a particular drug. They are also trained in professional ethics, public health and business management. Along with the training in the classrooms by professors, they also spend time with professional pharmacists in their practice. These professionals have appropriate license.
Some of the students who earn Pharm D degree, they also get further training of 1 to 2 years in residency programs and fellowships. If the students do pharmacy residencies, they also have to complete a research project to earn the complete degree of a pharmacist. If the students do pharmacy fellowships, they study highly advanced programs, so that they can work in clinics or research laboratories. There are some pharmacists who own their own pharmacy shops; they earn a degree in business administration and public administration so that they can easily handle the customers.
Before starting job as a pharmacist, a person must have a pharmacy license. To get this license, he first earns a degree in Pharm D from a recognized college. After getting the degree, the person passes through a series of other examinations. In some states of Columbia, the people who have done Pharm D, before giving license to them, their age is checked and some states even check the criminal background.
An experienced pharmacist can earn about 100,000$ in a year. The people who have an experience of one to four years in pharmacy, their annual salary is between 85000$ to 115000 dollars. In some cases, the salary of the pharmacists also depends on the qualifications and work experience. Location of the job is also important for good salary. For example, people who do their jobs in metropolitan cities, they are more likely to get higher salaries because of the high standard life styles and higher rents. Higher the degree greater will be the salary of a pharmacist. If a pharmacist is more experienced in his field, he will definitely get good salary.
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|I Know The Trick To Being Ill
|Chapter Info
|Chapter Chronology
Hayate no Gotoku! Chapter 518: I Know The Trick To Being Ill
Characters in Order of Appearance
- Fumi's shirt features a character heavily resembling the droid BB-8 from the film Star Wars: Episode VII The Force Awakens.
- Additionally, Sharna's shirt reads "Force be with you". This is a reference to the phrase "May the Force be with you" that is often used in the Star Wars franchise.


text:
Question about Bosch Dishwashers
Hello there,
Just wondering if you can help we have a Bosch dishwasher that is not working. When we put it on it makes a humming noise as if it is on, yet is not filling with water and and the soap dispenser is not opening. It will just sit there and hum antil we turn it off.
Do you have any idea what we can do to get it working?
Many Thanks,
Posted by 109unthank on
Dear customer,
For such cases we recommend you to follow the below stated routines..
Posted on Jul 09, 2008
and as for the drainning problem do the following check up..
Please Rate the Solution.. Thank You..
SOURCE: I have freestanding Series 8 dishwasher. Lately during the filling cycle water hammer is occurring. How can this be resolved
a 6ya expert can help you resolve that issue over the phone in a minute or two.
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Posted on Jan 02, 2017
Tips for a great answer:
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Here is a tip that I wrote that will help you with your dishwasher not draining problem...
Dishwasher Problems - Water will not drain out
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Spelunky on Playstation 4 (PS4)
Cheat codes, unlockables, hints, easter eggs, glitches, guides, walkthroughs, videos and more for the Playstation 4. Cheats.co has everything you need to dominate in-game!
Navigate using the links above or browse the Playstation 4 cheats we have available for Spelunky below. The most liked items overall will appear first in their respective section.
Submit Some Content! Leave a comment!
- Genre: Puzzle,Platformer,Action-Adventure
- Platforms: Xbox 360 Games Store,PlayStation Network (PS3),PC,PlayStation Network (Vita),PlayStation 4
- Developer: Mossmouth, LLC,BlitWorks
- Publisher: Mossmouth, LLC,Microsoft Studios
- Ratings: ESRB: T
- Release Date (original): 2009-09-01 00:00:00


text:
Today, while on holiday in England, a cute boy came up and asked where I'm from. When I said Paris, he gave a look and said, "Oh, strange, I always thought Parisians were the most beautiful women in the world." FML
100 kick-ass comments100 of your comments are neither buried or moderated. Popular is your middle name!0%
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The thumb strikes backYou have left your thumbprint on 2500 comments.0%
The return of the thumbYou have thumbed 5000 comments.0%
Keen reader – Level: student ninjaYou have voted for 15% of the entire collection of FMLs to date.0%
Keen reader – Level: master ninjaYou have voted for 50% of the entire collection of FMLs to date.0%
Keen reader – Level: godlike ninjaYou have voted for 100% of the entire collection of FMLs to date.0%
One more and it's business timeYou've received 68 Hugs on your profile. Kinky.0%
Today, there were a few loud and annoying kids running around my store. My coworker and I started talking and I jokingly stated "Yeah, kids ruin everything." But before I could get out "God knows I'm not ready to be a dad," my phone rang. It was my one night stand. I'm going to be a daddy. FML
Today, my mom was taking an online IQ test. To the question "On which continent is Canada located?" she responded "Antarctica." If intelligence is genetic, I'm screwed. FML
Today, I was shopping at a store from which I had previously bought a shirt. The clerk accused me of trying to steal my own shirt and called security. They examined it and argued with me for so long I was late to work. FML
Today, I got married. During the reception my husband got drunk and told 200+ people that we met at a dingy bar and that we "totally banged" all night. I don't know what's worse, the fact he embarrassed me in front of everyone I know, or if it was that that was not how we met. Not even close. FML


text:
Let us know when your receive great advice so we can thank our lawyers and point others with similar questions in the right direction.Got it!
will the 20 year old go to jail for dating the 16 year old even if the parents don't have any problem with their relationship?
Just dating and not having sex is one thing. Having sex and then the relationship blows up so that the potential for statutory rape charges come to the forefront is another.
There is no way to know from what little you post, and because no one can see into the future about whether the relationship will remain on good terms, but I observe this -- the 20 year-old is really playing with fire (a firestorm really) by having sex with a 16 year-old because of the age of emanicipation and age of minority concerns. This is so no matter what the parents say now.
Good luck.
NOTE: This answer is made available by the lawyer for educational purposes only. By using or participating in this site you understand that there is no attorney client privilege between you and the attorney responding. This site should not be used as a substitute for competent legal advice from a licensed professional attorney that practices in the subject practice discipline and with whom you have an atttorney client relationship along with all the privileges that relationship provides. The law changes frequently and varies from jurisdiction to jurisdiction. The information and materials provided are general in nature, and may not apply to a specific factual or legal circumstance described in the question.Ask a similar question
I agree with Attorney Brinkmeier. I would like to add there are several factors:1)what your state considers the proper age for a female to give consent; 2) how your state defines improper sexual contact or assault (traditionally known as statutory rape). In my home state of NJ a disparity of more than 3 years can meet the legal definition of sexual assault. and a woman can give consent at 16 (but other factors come in). As Attorney Brinkmeier posted this is not the wisest choice for a romantic relationship. I believe your state permits a woman of 16 to marry with her parents consent.
You might find my legal guide on selecting and hiring a lawyer helpful.
You might find my legal guide on Is it Legal? Is it Illegal? helpful.
You might find my legal guide on the understanding the different court systems helpful.
You might find my legal guide on legal terms used in litigation helpful.
Mr. Sarno is licensed to practice law in NJ and NY. His response here is not legal advice and does not create an attorney/ client relationship. The response is in the form of legal education and is intended to provide general information about the matter in question. Many times the questioner may leave out details which would make the reply unsuitable. Mr. Sarno strongly advises the questioner to confer with an attorney in their own state to acquire more information.
In Florida, you can have sex with a 16 year old as long as she really is 16 and you are under 24 years old. If she's 15 and lying about being 16, you are in trouble. If you are just dating without sex or sexual contact or conduct, then there wouldn't be a problem no matter your ages.Ask a similar question
In Florida, the age of legal consent is 16 years old. If a person is under 16 years old, they are not able to legally give consent to have any sexual contact.
In Florida, the ages of 16 and 17 also carry some legal restrictions. Florida Statute 794.05 describes "Unlawful sexual activity with certain minors" which indicates that it is a second degree felony for a person 24 years old or older to engage in sexual activity with a person who is 16 or 17 years old.
A minor can be "emancipated" having the disabilities of nonage removed under Florida Statute 743, including by getting married.
Florida Statute 794.021 makes it so that ignorance or belief as to victim's age no defense.Ask a similar question
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US Riders Sage Kotsenburg and Jamie Anderson take the Gold medals at the first Olympic Slopestyle. Amazing.Jr World Championships Slopestyle Course - Valmalenco, Italy
Slopestyle Snowboarding Competition is one of the most popular and highly participated in events in snowboarding. It's funny that the first Slopestyles events were only about 15 years ago. Before that the closest thing to a SlopeStyle was the occasional big air event or maybe a rail-jam once in a while.
Today, there are many Slopestyle events all across the country. Most Slopestyle events are held within a resorts terrain park and are basically a freestyle skills contest.
The Slopestyle Snowboarding Competition venue consists of a variety of features and components:
Most often the event is made up of a practice session, followed by the entire field taking 2 judged runs. The best score of the 2 runs will be used for ranking. In bigger events, there may be a cut performed to select finalist to compete in a second round final. The biggest events, like the US OPEN or the X-Games require a couple rounds of cuts.
A panel of 3 to 5 judges, judge skills and creativity on a 1-10 or 1-100 scale. The riders score is the sum of the judges scores. Judges score each rider based on:
The key to competing well in Slopestyle Snowboarding Competition is about making use of the course as a painter would a canvas. With well thought out preparation and precision execution the rider will flow from trick to trick and make it look smooth and effortless. Ways to ensure the best score-
The most important events in the Slopestyle Snowboarding Competition world are mainly the X Games, the US Open and now The Olympics. There are other important events like the TTR World Tour, European and Japanese Big Air events like the Innsbruck Air & Style, and like the now extinct Honda Sessions event at Vail. The Sessions, with massive jumps and the best in the world in attendance, saw some of the most incredible runs ever in competition. Some with a variety of 9s and beyond that, 3 different 1080's in one run. Dang!!
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Events for October 18, 2013
Day Navigation
All Day
2013 Devine Inspirations Fall Conference Registration
Join the Devine Inspirations Family Ministry for two concerts and ten breakout sessions! Friday's concert about family & Saturday's for Christmas. Choose to attend Saturday's breakout sessions with Adam and Rebecca Devine to build faith or to build employment skills. Bring some friends with you. No admission charge. Free will offering. Registration by October 20 is more »Find out more »
Mad about Marriage
Mad about Marriage is a seminar with husband and wife team Mike and Gayle Tucker. It will be taking place on Friday, Oct. 18th from 6:30 to 8:30 pm and Saturday, Oct. 19th from 2:00 to 5:30 pm at Hanover Seventh-day Adventist Church. For more information please visit the website at http://www.madaboutmarriage.com/.Find out more »
6:30 am
Life's Healing Choices
Life's Healing Choices offers freedom from our hurts, hang-ups, and habits through eight healing choices that promise true happiness and life transformation using the Beatitudes of Jesus as a foundation starting Oct. 18th from 6:30-8PM at House of Blessings in Ephrata. Runs 8 weeks. 7173343708Find out more »
8:30 am
How To Build "High Performance" Organizations
How To Build "High Performance" Organizations at Duncannon EMS on Oct. 18th from 8:30-10:30AM. Learn how to implement processes that will lead your organization to High Performance. Leading an organization with clarity in Mission, Vision and, most importantly, Values makes good business sense. Organizations that do that successfully are called, "High Performance Organizations," or simply more »Find out more »
10:00 am
Healing Prayer
Healing Prayer takes place each week at our headquarters, The Londonderry Inn,Wednesday and Friday, 10am – 12 Noon, by appointment. Our healing teams are from a variety of regional churches and have been trained and commissioned by Healing Tree International. They come together twice a week to pray for healing for body, mind, and spirit and more »Find out more »
4:30 pm
Mission Team Spaghetti Supper Fundraiser
Mission Team Spaghetti Supper Fundraiser on Oct. 18th from 4:30-8PM at Enola First Church of God. Arrive between 4:30 and 5:00 to get a free dessert! Profit to be applied towards the Enola First Church of God's Mission Trip to New Mexico in July of 2014 to minister to the people of the Navajo Tribe. 717-732-4253 more »Find out more »
5:30 pm
Representative Gordon Denlinger Banquet – Defending Liberty and Freedom
You are invited to join State Representative Gordon Denlinger and featured speakers, Representative Sam Rohrer and Senator "Citizen Mike" Folmer at a banquet to celebrate America. Gordon's event, honoring our liberties and freedoms, will be held Friday night, October 18th from 5:30-8:00 pm at Yoder's Restaurant in New Holland. Tickets and registration information can be more »Find out more »
Join State Representative Gordon Denlinger for a banquet to celebrate America
You are invited to join State Representative Gordon Denlinger and featured speakers, Representative Sam Rohrer and Senator "Citizen Mike" Folmer at a banquet to celebrate America. Gordon's event, honoring our liberties and freedoms, will be held Friday night, October 18th from 5:30-8:00 pm at Yoder's Restaurant in New Holland. Tickets and registration information can be more »Find out more »
6:30 pm
Mad About Marriage Two Session Seminar
Mad About Marriage presented by Mike & Gayle Tucker is a two session seminar. Begins Friday, Oct. 18th from 6:30 to 8:30pm and then meets again Saturday afternoon at 2:00pm until 5:30pm at Hanover Seventh-day Adventist Church in Hanover. Learn ways to stay "madly in love" forever. 7177663015Find out more »
"Fight Your Way to a Better Marriage" with Dr. Greg & Erin Smalley
New Joy Church is hosting its 3rd annual marriage conference on Friday evening, October 18 from 7 pm to 9 pm & Saturday morning, October 19 from 9 am to 12:30 pm. The theme this year is "Fight Your Way to a Better Marriage" with special guest speakers Dr. Greg & Erin Smalley from Focus on more »Find out more »
Creator's Jubliee @ CrossRoads Ministries
Creator's Jubliee @ CrossRoads Ministries in Leola on Oct. 18th from 6:30-9:30PM. CrossRoads Ministries seeks to provide an avenue for Christian artists to share their God-given artistic talents with others in a relaxing atmosphere. It is the goal of this ministry to be an outreach to the Christian community in the hopes to provide Godly more »Find out more »
7:00 pm
WJTL's Family Movie Night
Turkey Hill Dairy's All Natural Ice Cream Presents: WJTL's Fall Event Series Family Movie Night on Fri. Oct. 18th at 7PM. "Brave" Free Event, but you must have tickets! Tickets available on Fri. Oct. 4th at 9AM. 717-459-3701 http://www.cmilive.com/Find out more »
Bizzle in Lancaster
Cross Culture Friday, October 18th at 7PM at In The Light Church 415 South Shippen Street Lancaster PA. Bizzle is an unbelievable national Christian rapper that will be performing live thanks to a generous sponsor. Admission is free! Niv (717) 344-7757Find out more »
Author Mark Van Steenwyk, to discuss his new book, "The UnKingdom of God", at Cafe One Eight.
The Community Haus will be hosting a free meet and greet, with author Mark Van Steenwyk, on Friday, October 18th at 7pm. Mark will be discussing his new book, "The Unkingdom of God," which was released through InterVarsity Press. This free symposium, will be taking place at Cafe One Eight, located at 18 W. Orange more »Find out more »
Coffeehouse to benefit orphans
Coffeehouse to benefit orphans on Oct. 18th from 7-9PM at THE MILL in Lititz. FUNDRASER : LIVE MUSIC, SPECIALTY COFFEES AND HOME made DESSERTS. 7175815784Find out more »
Coffeehouse & Open Mic Night with Stuart Young
Join us on Friday October 18 from 7-9 PM at the Community Room on King for our 1st Coffeehouse and Open Mic Night in our new space. The featured performer that night will be Stuart Young. Stuart says this about his music, "I am just an everyday guy walking this journey of a life. I more »Find out more »


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What is JotForm?
JotForm is a free online form builder which helps you create online forms without writing a single line of code. No sign-up required.
At JotForm, we want to make sure that you're getting the online form builder help that you need. Our friendly customer support team is available 24/7.
We believe that if one user has a question, there could be more users who may have the same question. This is why many of our support forum threads are public and available to be searched and viewed. If you'd like help immediately, feel free to search for a similar question, or submit your question or concern.
Changing form error messageAsked by ALC391 on March 31, 2015 at 03:43 PM
How do I change the layout and wordings of the form submission error screen?
JotForm Support
Thank you for contacting us.
Form warnings can be changed via form Preferences, see the next guide:
If you are referring to the server side validation page, unfortunately it can not be changed at this time.
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text:
Created for FutureLearn by London illustrator Rob Lowe (aka Supermundane), this poster is an explosion of characters and colours.
Inspired by the University of Nottingham's free online course "How to Read a Mind," it explores how fictional people in imagined worlds get inside our heads.
- A2 size: 59 x 42 cm (16.5 x 23.4 inch)
- Printed on 200gsm matte paper


text:
|Message view
|« Date » · « Thread »
|« Date » · « Thread »
|"Dhruva B. Reddy" <sledgehammer2...@yahoo.com>
|RE: heap size
|Wed, 23 Jul 2003 17:22:36 GMT
I recently discovered these two methods, and was wondering how accurate they are. I am a bit confused: I am running Tomcat 4.1.18 on Linux, with JDK 1.4.1_03-b02. Nowhere in the startup scripts do I see it specified how much memory to use (i.e., with the -Xmx flag). When I call Runtime.totalMemory(), it gives me 128MB, yet I was under the impression that the JVM sets aside 64MB by default. On a possibly unrelated note, is it feasible to force garbage collection on Tomcat's JVM, either through Tomcat or the JVM itself? Googling has revealed only the official answer to this question, but I've heard that most profilers can do this. Thanks, Dhruva --- "Shapira, Yoav" <email@example.com> wrote: > > Howdy, > > >Thanks Yoav - one last dumb question and I will leave you alone! So > by > > There's more than one in this email ;) And no question is dumb > (although that assertion is frequently tested on this list). > > >adding that to my environment variables list, Tomcat knows to add it > as > a > >startup parameter for Java? Or do I need to specify something else > in > the > > No, it's one of a small set of variables documented in > $CATALINA_HOME/bin/catalina.sh that tomcat looks for. Environment > variables don't need to be on the classpath. > > >Is there an easy way to check the JVM to > >see the parameters once it is running?? > > Generally, no, but there are some exceptions. Although in this > specific > case, you can get memory information via Runtime#totalMemory() and > Runtime#freeMemory(). > > Yoav Shapira > > > > > This e-mail, including any attachments, is a confidential business > communication, and may contain information that is confidential, > proprietary and/or privileged. This e-mail is intended only for the > individual(s) to whom it is addressed, and may not be saved, copied, > printed, disclosed or used by anyone else. If you are not the(an) > intended recipient, please immediately delete this e-mail from your > computer system and notify the sender. Thank you. > > > --------------------------------------------------------------------- > To unsubscribe, e-mail: firstname.lastname@example.com > For additional commands, e-mail: email@example.com > __________________________________ Do you Yahoo!? Yahoo! SiteBuilder - Free, easy-to-use web site design software http://sitebuilder.yahoo.com --------------------------------------------------------------------- To unsubscribe, e-mail: email@example.com For additional commands, e-mail: email@example.com
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text: Kneeling guys and the Oracle The kneeling guy is a character found in Strife. Many of them can be found in the Temple of the Oracle. They do not harm the player; they only kneel and pray incoherently. They are holograms. If damaged enough, they disappear, leaving a projector on the ground. Retrieved from "http://doom.wikia.com/wiki/Kneeling_Guy?oldid=92101" Ad blocker interference detected! Wikia is a free-to-use site that makes money from advertising. We have a modified experience for viewers using ad blockers Wikia is not accessible if you've made further modifications. Remove the custom ad blocker rule(s) and the page will load as expected. Categories: Strife characters


text:
18 And Lovin' It 2Favorites [+]
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You can now enjoy this movie on your iPhone®, iPad®, or compatible Smart TV & Android devices.
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DRM-free downloads offer content that is not limited by standard Digital Rights Management (DRM) access technologies. These technologies allow hardware manufacturers, publishers, copyright holders and individuals to limit the usage of digital content.
When you purchase DRM-free downloadable content, that content is available for you to download on any computer and save to a disk whenever you like. You can also download to multiple computers. There is no timeframe associated with your purchase and the content will not expire.
Running Time: 105 minutes
Released: 08/2009
Studio Name: Baby Doll Pictures K-Beech
Series: 18 And Lovin' It
Description: Oh my, how quickly they grow up. Little Jassie just turned 18 and she's lovin' it. She can't wait to rush home from school and fuck her brains out. All her young friends are just as cute and horny too. They can't get enough cock!
6 Scenes from 18 And Lovin' It 2
18 And Lovin' It 2: Scene 1 Free Preview
Starring: Jassie Anthony Hardwood ... More Details
Stars: Jassie, Anthony Hardwood
Positions: Standing Doggy Style, Standing, Side Saddle, Spoons position, Missionary, Laying, Reverse Cowgirl, Kneeling
Settings: Living Room
18 And Lovin' It 2: Scene 2 Free Preview
Starring: Alexis Malone Tyce Bune ... More Details
Stars: Alexis Malone, Tyce Bune
Sex Acts: Vaginal Sex, Deep Throating, Oral Sex
Positions: Standing Doggy Style, Standing, Missionary, Laying, Reverse Cowgirl, Cowgirl, Kneeling
Settings: Poolside
18 And Lovin' It 2: Scene 3 Free Preview
Starring: Takota Reno D'angelo ... More Details
Stars: Takota, Reno D'angelo
Positions: Standing Doggy Style, Crouching/Squatting, Standing, Standing Missionary, Missionary, Laying, Reverse Cowgirl
Settings: Living Room
18 And Lovin' It 2: Scene 4 Free Preview
Starring: Anthony Hardwood Christie Lee ... More Details
Stars: Anthony Hardwood, Christie Lee
Positions: Standing Side Saddle, Standing Doggy Style, Standing Cowgirl, Standing, Standing Missionary, Side Saddle, Laying, Reverse Cowgirl, Cowgirl
Settings: Bathroom
18 And Lovin' It 2: Scene 5 Free Preview
Starring: Barrett Blade Cole Connor ... More Details
Stars: Barrett Blade, Cole Connor
Sex Acts: Vaginal Sex, Deep Throating, Oral Sex, Tittie Fucking
Positions: Standing Side Saddle, Standing, Standing Missionary, Side Saddle, Spoons position, Missionary, Reverse Cowgirl, Cowgirl, Kneeling, Doggy Style
Settings: Bedroom
18 And Lovin' It 2: Scene 6 Free Preview
Stars: Krysta-Lynn Lovely, Anthony Hardwood
Sex Acts: Anal Sex, Vaginal Sex, Cum Swallowing, Oral Sex
Positions: Standing Doggy Style, Side Saddle, Laying, Reverse Cowgirl, Cowgirl, Kneeling
Settings: Bedroom
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Up to $250 in Coupons Betty Crocker + Samples, Free Recipe Book and More!
If you love Betty Crocker products, be sure to sign up for the FREE Betty Crocker Newsletter and get up to $250 a year in coupons! As an added bonus, you will also have the chance to get Free Samples Every Month + FREE Cookbook!


text:
- Vinogradoff
- biographical name Sir Paul Gavrilovitch 1854-1925 British (Russian-born) jurist & historian
New Collegiate Dictionary. 2001.
New Collegiate Dictionary. 2001.
Vinogradoff — noun British historian (born in Russia) (1854 1925) • Syn: ↑Sir Paul Gavrilovich Vinogradoff • Instance Hypernyms: ↑historian, ↑historiographer … Useful english dictionary
Vinogradoff, Sir Paul Gavrilovitch — ▪ British legal scholar Russian Pavel Gavrilovich Vinogradov born Nov. 18 [Nov. 30, New Style], 1854, Kostroma, near Moscow, Russia died Dec. 19, 1925, Paris, France Anglo Russian legal scholar and medievalist who was perhaps the… … Universalium
Paul Vinogradoff — Paul Gavrilovich Vinogradoff Born 30 (18) November 1854 Kostroma, Russia Died 19 December 1925(1925 12 19) (aged 71) Paris … Wikipedia
Sir Paul Gavrilovich Vinogradoff — noun British historian (born in Russia) (1854 1925) • Syn: ↑Vinogradoff • Instance Hypernyms: ↑historian, ↑historiographer … Useful english dictionary
Bookland (type of land) — dablink Not to be confused with the Swedish provinces known as Folkland .Folkland (O.E. folcland ) and bookland (O.E. bocland ) are the two types of land tenure under Anglo Saxon law. Bookland refers to land that was vested by a charter, and all… … Wikipedia
Feudalism — • The source of feudalism rises from an intermingling of barbarian usage and Roman law Catholic Encyclopedia. Kevin Knight. 2006. Feudalism Feudalism … Catholic encyclopedia
Anglo-Saxon law — While there is virtually no evidence of Anglo Saxon law per se (i.e. case law and jurisprudence), a significant amount of the literature of law from the Anglo Saxon period still survives. Discussion of Anglo Saxon law must, therefore, be confined … Wikipedia
Ambassade de France au Salvador — France … Wikipédia en Français
Crime — Criminal redirects here. For other uses, see Crime (disambiguation). Justice and Divine Vengeance in pursuit of Crime 1808 oil on canvas … Wikipedia
Lady Ottoline Morrell — Lady Ottoline Morrell, 1902 The Lady Ottoline Violet Anne Morrell (16 June 1873 – 21 April 1938) was an English aristocrat and society hostess. Her patronage was influential in artistic and intellectual circles, where she befriended writers such… … Wikipedia


text: Overview Gallery Quotes Gallery Booth from Arms Deal Update Page.Booth in Operation Bravo Update pageBooth during Operation Wildfire.Add a photo to this gallery Retrieved from "http://counterstrike.wikia.com/wiki/Booth/Gallery?oldid=115493" Ad blocker interference detected! Wikia is a free-to-use site that makes money from advertising. We have a modified experience for viewers using ad blockers Wikia is not accessible if you've made further modifications. Remove the custom ad blocker rule(s) and the page will load as expected. Categories: Image gallery


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Contemporary Human Geography (2nd Edition)
Contemporary Human Geography is a beautifully crafted, modular springboard into essential human and cultural geography concepts, designed for the contemporary geography student. This brief, innovative text explores current human geography in the bold visual style that distinguishes Dorling Kindersley (DK) publications. Topics within each chapter are organized into modular, self-contained, two-page spreads. Together with the graphics, Rubenstein s efficient writing engages students, presenting information clearly without sacrificing the high-quality geography content essential to students and instructors.
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Video: Evelyn Cusack gets through disastrous weather report like a pro
The long-time presenter used all her skills to deliver the weather forecast when all sorts of problems cropped up in the post SIx-One bulletin this evening.
It all started off as normal but as soon as Cusack went to use the charts behind her she realised she was in trouble.
It appears, for reasons as yet unknown, that the charts were completely wrong.
Cusack was, understandably, initially confused at the failure of the trusty clicker to bring up the right image but once she realised that the technology had gone awry, she delivered a rather excellent forecast without any images or charts to illustrate the weather.
Hats off Evelyn, you're a real pro.


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Educational Membership Videos
LRA 2-Minutes
To run a success restaurant, you have to know a lot, about a lot of things. To aid members in understanding some of the most complex issues in our industry and provide them with resources to learn more, the LRA developed the LRA 2-Minutes (you need to know) series.
This series is ongoing and shared through member communications and are just one way the LRA strives to educate its members on timely topics and relevant topics.


text: Sorry for the vague title, but I find this quite difficult to explain lol. I'm making this thread out of curiosity really. Soon, we're swapping domains and moving to a different domain as a subdomain. Okay that sentence sounds absolutely stupid for some reason, but we're basically going from wweforums.net to forums.watchwrestling.net for a variety of reasons. If you were merging them, is that what you would do? Is it simply a case of installing Xenforo to that subdomain, getting the necessary redirects ready, and moving it? Will we take a hit to Google traffic sources when someone Googles a topic that we have covered in a thread? I don't think we will, but I'm naturally paranoid since I've worked on wweforums since 2011 on that domain. I just want to know if you lot would do the same or if there's something I am missing. Thanks guys.


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Many writers covering the launch of a new magazine would mention that its inaugural issue had been boycotted and removed from thousands of chain-store racks because of a copyright infringement case that continues to rage.
Not Peter Carlson, though. That would be too...obvious.
In the prophetically titled Avert Your Eyes! And Your Brain! in today's Style section, Carlson appears not to have gotten the memo on war correspondent Michael Yon, whose heart-rending photo of an American soldier cradling a bloodied Iraqi child was used without Yon's permission in the inaugural issue of Shock. In fact, one of the photos illustrating Carlson's story reproduces that cover, but rather than even a hint about this debacle Carlson cracks wise about Jessica Simpson photos.
The story has all the signs of being dashed off after receiving a press packet from publisher Hachette Filipacchi Media, which may have forgotten to mention the controversy. Carlson describes the atmosphere of the publication well enough--photos of everything from rotting chicken heads to rotting human corpses. Using Yon's iconic photo without permission to launch a major commercial enterprise that has all the class of a freak show kind of ticked him off. So did the magazine's use of the photo to frame Iraq as another Vietnam.
The result? So far, over 7,000 retailers have have halted the magazine's distribution, including Rite-Aid and Eckerd's, and the battle rages on. Here's the situation as described by Yon back on May 26:
Many people have become aware of a recent serious photo copyright infringement. The photo in question is that of Major Bieger holding a little Iraqi girl named Farah who was killed by a suicide car bomber in Mosul, Iraq. I first became aware of the infringement when stunned and angry readers contacted me under the mistaken belief that I allowed SHOCK magazine to use it on their cover. I did not, and never would have agreed to their usage. I regularly turn down usage requests for this photo — uses that could earn money — because this photo is sacred to me and is representative of the U.S. soldiers I have come to know. It is also representative of the horrors of the enemy we all face.
My attorneys are in discussions with those at fault, and we have demanded that all copies of the magazine be removed from circulation and from the internet....
One of the latest developments is a settlement with Polaris Images, detailed here in a June 28 story by PDN Online (pdf), which like other links in my post comes from Yon's own website. A settlement between HFM and Yon broke down, and further developments are being tracked by Yon here.
Cross-posted at PostWatch


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he Iranian rial has crashed. Over the past 36 hours, it has lost almost 30 percent of its value. The value of the dollar against the rial is now up around 300 percent from what it was just a couple years ago. After long denying that the sanctions have had any effect on Iran, President Mahmoud Ahmadinejad now blames outside "enemies" for the country's economic trials.
Read Full Article »


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Photo by Brian Canniff – UltiPhotos.com
D.C. Current cutter Calvin Oung snatched up the US Coachways Offensive Play of the Week honors for the deflected score he caught against the Philadelphia Spinners to end the first quarter last Saturday.
D.C. received the disc as the final seconds ticked off the clock in the first quarter. Markham Shofner picked up the pull and executed a quick give and go with Lloyd Blake to advance the disc near midfield. After skying to grab the disc over a pair of Philadelphia defenders, Shofner quickly set his feet and launched a lofty backhand headed towards the end zone.
A crowd of players huddled underneath the disc and several had a chance to make a play on it; however, Oung would ultimately secure possession after the frisbee had been tipped numerous times.[bc width="628px" height="360″]http://tv.mlultimate.com/detail/videos/latest/video/4290953101001/2015-week-8—us-coachways-offensive-play-of-the-week[/bc]
"I misread the disc a bit and basically witnessed the disc pinball off three or four people until it fluttered and dove toward the ground," said Oung. "It felt like the disc was suspended even though it fell fast in real time. I lunged for it and barely got to it before the ground did.
Tip catches are difficult since the frisbee has lost most of its rotation and uniform motion post-tip. Usually, if I don't think I can catch a frisbee outright, I plan for a tip. You can't predict where the tip goes but at least I've prepped my mind and body so that I can react to the tip as quickly as possible."
Come cheer on Oung and all of the other Current stars as they take on the Boston Whitecaps in the squad's final home game of the regular season this Saturday. First pull is scheduled for 6:00 p.m.


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Clown Cake from Course 1 - Chocolate Cake with Class BC icing...learned how to stripe the icing bag and went a little crazy with it...had fun though!
Wilton Class 1 - Clown Cake
Wilton Cake Class; Course 1--Clown Cake--11/17/09
Class I Clown
Good first try, cute clowns and nice use of striping technique


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Carolyn Murphy splits from Lincoln Pilcher
Carolyn Murphy has reportedly broken up with her boyfriend Lincoln Pilcher.
The 42-year-old model-and-actress has split from the photographer, model and restaurateur after three years together, according the New York Post newspaper.
The Estee Lauder model and Lincoln have been famously private about their relationship and they have rarely been seen together in public.
Carolyn previously said: "There are some things we have to keep sacred."
However, the blonde beauty and her ex-boyfriend were open about practising transcendental meditation together, while Carolyn has also worked with an energy healer for more than 20 years.
Carolyn previously admitted: "She's one of my secrets to staying sane."
Carolyn was married to entrepreneur Jake Schroeder, with whom she has teenage daughter Dylan Blue, from 1999 until 2002.
Subsequently, she also dated Brandon Boyd, the lead vocalist of the neo-grunge band Incubus.
However, the American beauty has stressed that there is much more to her than her enviable good looks.
Carolyn previously said: "So often the American woman has been typified by a standard of outward beauty: blond hair, blue eyes, healthy build.
"I see the evolution of the real American woman as being more about her spirit.
"She can roll up her sleeves and get dirty. She can do it all - she is classy and she is casual. Neither holds more importance than the other, and the beauty is in her effortlessness."
Indeed, Carolyn claimed her nationality forms a major part of her identity.
She shared: "I've been cast as every blonde icon, you name it: Grace Kelly, Romy Schneider.
"But what's interesting to me now is what lies behind the facade of the photo - this idea of being American, and what that means, how that defines you."


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Ben McKenzie Knocked Up Morena Baccarin Already
Morena Baccarin knows Commissioner Gordon's son grows up to be a serial killer, right? Just checking. More »
Morena Baccarin knows Commissioner Gordon's son grows up to be a serial killer, right? Just checking. More »
I'm going to shoot it to you straight. Today is technically a work holiday, so I let Photo Boy have the day off because he's like my sla- a trusted employee! I was going to say trusted employee. So here's my attempt at a SAG Awards red carpet gallery/a> which may or may not be… More »
We've already spent way too much time on the Emmys, so here are the rest of the red carpet pics featuring such classics as Rapidly De-Aging Skylar White, an act of terrorism, Julianne Hough & The See-Through Butt, My Dick Is Huge I Can Laugh However I Want, Haha! Superman Dumped You, Bring Your Viral… More »
Posted by Photo Boy
Ridiculously dubbed "Nerd Prom" this year by people who clearly don't understand how politicians are more like jocks than any other high school clique, the annual White House Correspondents' Association Dinner was unsurprisingly boring since it's a gathering of people who either know their every move is being publicly… More »


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Covenant of Liars
by tenshinrtaiga
Disclaimer: I don't own the Covenant or Pretty Little Liars
Primary Characters: Alison DiLaurentis, Spencer Hastings, Aria Montgomery, Emily Fields, Hanna Marin, Chase Collins, Caleb Danvers, Pogue Parry, Reid Garwin, Tyler Simms.
Secondary Characters: Ezra Fitz, Wren Kingston, Samara Cook, Sarah Wenham, Kate Tunney, Caleb Rivers and more.
Pairings: canon pairings plus some Caleb D./Spencer, Aria/Reid, Alison/Chase
Summary: No one really knows how the Power came to be. Not even the Book of Damnation recorded its beginning. But those who mastered it have always been hunted. In the middle of the 17th Century, many escaped the brutal Witch-hunting in England and France by coming to America. As the brutal persecution of those with the Power spread throughout Massachusetts, the ten families of Ipswich (Danvers, Hastings, DiLaurentis, Putnam, Parry, Fields, Montgomery, Garwin, Simms and Marin) formed a Covenant of silence. And for 300 years it has kept them safe. Until now.
Alison, Caleb, Spencer, Pogue, Reid, Aria, Emily, Hanna and Tyler have to deal not only with their own high school drama, but the strange supernatural ones that keep popping up. And it doesn't help that the Covenant of silence is splitting at the seams as Spencer deals with her family, Caleb finds himself in love with someone else and Aria falls for her new teacher. And of course, further splitting the group, there's Alison and the girls as they try and secretly deal with That Jenna Thing.
Another day is gone
Washed away with sorrows that you dwelled upon
And as the moon is rising, you think to yourself
I could be gone, if I go now
Caleb tried to drag himself up and out from a fallen beam, but Chase just kept throwing powerballs while he was down. "Like taking candy from a baby," he smirked.
Pissed off, Caleb gave a grunt before sending a powerball of his own to knock Chase off his feet. Chase quickly got up and started sending one shot of energy after another, but Caleb just dodged them going back and forth and flying up and down. Chase got in a lucky shot and dragged Caleb across the room before throwing him through the loft floor.
Caleb weakly struggled to stand up, but didn't see the boy any longer. "Easy as pie," Chase taunted from behind him causing Caleb to whirl around. As soon as he had turned, Chase threw another energy ball at him causing him to hit a beam.
"You find her?" Tyler asked as he and Reid met back up in the courtyard.
"No," Reid responded having looked everywhere.
Aria shook her head but kept her grip on Samara's hand firm. "I can't believe you guys lost Sarah while we were working on scouting the gym."
"Look-" Reid replied angrily before cutting himself off. It would be no use getting angry with the girls. It wasn't their fault that he and Tyler dropped the ball. He looked down at his watch and gave the others a worried look. "Twelve minutes past eleven."
"Happy birthday, Caleb," Spencer whispered staring up at the sky in fear.
Caleb gave a scream as lightning struck his body and a huge surge of power came off his body in waves. Chase floated to the ground for a better look. "Are we Ascending?" he laughed. "Finally!" He threw a powerball at the boy's chest knowing that Caleb was in too much pain to fight back. "Scary, huh, Caleb? This new power you get when you Ascend. Frankly, I don't think you're cut out for it, so why don't we just call it a night? Just say the words." Caleb finally ceased screaming as his body liquefied and reformed. He quickly looked up and began sending a barrage of powerballs in Chase's direction. "Okay, I'm a little impressed," Chase laughed, wiping the dirt of his clothes. "Not bad."
"Thanks," Caleb spoke from behind the boy, causing him to whirl around in shock at their reversed positions. Caleb swiftly threw a powerball, knocking Chase through three stables.
Chase got up with a laugh. "Trying to impress your date, huh?" he asked gesturing toward the slumbering Sarah. Angered, Caleb threw another shot of energy, but Chase ducked before sending a large plow in Caleb's direction. Caleb ducked but the move gave him an idea and he looked at a large rack of farming tools and sent a multitude of pitchforks at the other boy. Chase Used to deflect them and when Caleb sent an energy blast, he plucked it out of this air, causing Caleb to pause in shock. Chase then sent the ball back, causing the surprised boy to fall back into a large pile of wood and crates. Caleb could no longer get up, he was in so much pain. Chase gripped his hair tightly and shoved his head up forcing him to look at Sarah. "You ready to say uncle?"
"I'm ready for you to go to hell," he sassed back.
With a flare of his eyes, Chase caused a fire to come to life near Sarah's body. He then levitated Caleb up and flung him out a window into the harsh rain outside.
"Just say the words," Chase spoke, serious for the first time that night as he stalked closer to the injured boy. "Say the words and it's all over." When Caleb remained silent, Chase dropped to his knees to hover over the boy. "Come on. Say it. Say the words. I…" Chase started off.
"I," Caleb mimicked.
"Will you…" Chase continued.
"Will you."
"…" Chase nodded waiting for the rest of the sentence.
"Nothing," Caleb snarled as he kicked a leg out, smashing into Chase's face with both his foot and a powerball.
You can't turn back the hands of time
Just let it go and you'll be fine
What's done is done and it's alright
You can't turn back the hands of time
"He is your son," Evelyn begged her husband with tears in her eyes. "For once in your life think of someone other than yourself."
"I," William Danvers used what was left of his magic to speak despite being physically unable to, "will you my power." His eyes flared with fire one last time before glazing over in death.
Caleb looked down in surprise, unsure of how he caught Chase's powerball. He glanced up in time to see lightning strike him for the second time that night.
Chase too looked at the sky in confusion before realizing someone must have willed the boy their power. He lunged at Caleb while the brunet was still distracted with the new power, but Caleb threw his charged powerball and sent Chase into a fiery inferno.
Caleb quickly made his way into the burning barn, making his way to Sarah. He gently lifted her up out of the stasis spell and carried her outside. He laid her on an old cart and gently stroked her cheek, hoping to see her wake up. He gave a wide grin when her eyes fluttered open, looking around in confusion. Across town, Hanna, Pogue, Emily and Kate also woke up from the spells that Chase put them under.
Life is a carousel
Dancing round the mirrors, we go up and down
So let the music take away the hurt you've come to know so well
Let it go 'cause...
"Caleb!" Spencer screamed as she jumped out of the Hummer to look upon the burning wreckage of the Putnam Barn.
"We're okay, Spence," Caleb called out from behind a fire truck. He was leaning against his car and Sarah sat inside, curled up around a blanket the EMT gave her. When the four got closer, he whispered a quick. "Chase died in the fight."
"Oh thank god," Aria muttered turning to hug Reid. She had never been so terrified in her life.
"And Emily?" Samara asked worriedly.
"Sarah's out from his spell so I bet they are as well," Spencer answered. "We'll head to the hospital soon," she promised.
"Look, see," Caleb nodded as the EMT brought out a gurney with a black body bag on it. "Chase will never bother us again," he stated resolutely, gripping Sarah's hand tightly.
Suddenly, several cell phones rang at once. Spencer, Caleb, Reid, Aria and Tyler all brought out their phones to read a surprising message.
Chase might be gone, but I'm still here. And I know everything. Better watch out, bitches. -A
There was a scary and uncomfortable silence as the message sank in.
"It's probably Alison messing with us," Spencer laughed uncomfortably, though she didn't sound certain.
Caleb nodded. "Yeah, sounds like Ali."
A policeman came up to the teens, looking at Caleb. "I'm sorry, Mr. Danvers. We searched the area, but we didn't find Mr. Collins."
The teens all turned to look at the gurney in confusion. "Then who's that?" Caleb asked.
The cop shifted uncomfortably. "I'm afraid that's Miss DiLaurentis," he finally admitted after an internal debate. "I'm sorry for your loss."
"Wait, what?" Aria cried out. "There's some sort of mistake! Alison's in Georgia."
The cop turned to look at her sympathetically. "I'm afraid there's no mistake, ma'am. That is Alison DiLaurentis." He turned to look at the group. "Again, I'm sorry for your loss," he apologized before leaving the devastated teens.
Once more, five phones rang signaling a message.
Sorry, did I say bitches? I meant to say witches. See, I do know everything. Don't worry. You'll hear from me again soon. –A
You can't turn back the hands of time
Just let it go and you'll be fine
What's done is done and it's alright
You can't turn back the hands of time
music is Hands of Time by Rachel Diggs


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EUROPE: EC price survey shows no convergence
The latest European Commission survey of car prices has found that prices are not converging towards levels in high price countries and that they have increased less than inflation, according to Reuters.
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0 item($ 0.00) ·
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is on back order
Luxman is pleased to announce the L-507uX this merger of transistor amplifier, the 4th version of the highly rated X series, with a high output power of 110W(8Ω) 220W(4Ω). The L-507uX integrated amplifier introduces Luxman electronically control attenuator LECUA, with an illuminated central oriented VU meter on its solid, symmetrical facia, also includes the Luxman exclusive super sound quality feedback circuit ODNF high S/N version 3.0,while keeping all the superb features of Luxman products made in Japan.
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Do some 3D Modelling
Budget €3000-5000 EUR
We are looking for advanced 3D artists who have experience in making photo-realistic renders of interiors and products for print and web.
Thanks in advance
76 freelancers are bidding on average €3476 for this job
Hello There, We can help you by creating awesome high quality model/render. We have a strong hand in 3D Maya, Max, Unity 3D and AR/VR and have tons of experience of the same. Here you can check some of our rec More
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Connecting Families to Senior Living
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*Prices quoted are monthly rental charges and are provided by the communities themselves. Actual prices may differ due to one-time fees, timing and care services required. Speak with your Senior Living Advisor to learn more.
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At Senior Care Assisted Living, we care more about the quality of your elderly loved ones life, as opposed to them just being another person who lives with us. Furthermore, we know that when it comes to being a senior that senior care is more about a time of experiencing joy as opposed to hardship, and we at Senior Care assisted living want to make that a reality for you senior. Let us do that. Let us do that by providing real care when it comes to being generous, compassionate, heartfelt, warm, and more. Let us do that with all that we have to offer in assisted living, such as near by hospitals, genuine and true compassion, wonderful meals that we prepare from scratch, and much more. We also offer inpatient rehab and memory care for those who need a little more assistance. We are originally based out of Louisville, Kentucky, but we are proud to have a wide variety of locations, so that your elderly loved one can find the best place to live. Remember, your golden years, shouldn't include pain and sorrow, but instead they should be filled with real quality care, happiness, joy, and much more. Get what you need with people who truly care. Get it with Senior Care Assisted Living.
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Just this morning we were discussing how much the place has
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reduced to eating, napping, watching tv and sleeping."
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The property we are using is run by the brother of the owner of Rose of Sharon. Our Mom needed two care givers on staff at all times. So she is at a home at 8108 S Harrison Way. Can't remember t... more...
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How to Connect external USB devices to an Apple iPad
In this clip, you'll learn how to use external USB-powered peripherals with an iPad. Whether you're the proud owner of an Apple iPad or perhaps just considering picking one up, you're sure to benefit from this free video tutorial. For more information, including a detailed overview, watch this iPad user's guide.