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OpenStack Silicon Valley is an OpenStack community event that brings together many of the greatest minds in the infrastructure industry to discuss and debate the latest and hottest trends in open cloud. After tremendous success at the inaugural OpenStack Silicon Valley last year, we are expanding this year to a 2-day event, organized as a community event with the OpenStack Foundation.
Held once again at the Computer History Museum in Mountain View, OpenStack Silicon Valley will feature diverse speakers including industry analysts, top contributors and business leaders in the OpenStack community and broader cloud industry.


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|ba3 <sbadhrin...@gmail.com>
|Multiline Regex with Lucene
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I was trying to do a regex search with the lucene and JavaUtilRegexCapabilities. The code used is : RegexQuery query = new RegexQuery(new Term("contents","(?m)hello.*(\r[^#]*)This is to be searched.*(\r[^#]*)#")); query.setRegexImplementation(new JavaUtilRegexCapabilities()); I verified the regex in : http://www.gskinner.com/RegExr/ [with the multi line checked] In lucene though there are no hits. Can you please point me in the right direction -- Rgds Ba3 Regex : hello.*(\r[^#]*)This is to be searched.*(\r[^#]*)# Content : hello world This is to be searched # Test line should not be selected hello This should not work some other lines # Not to be selected hello world Some lines This is to be searched Some lines # hello earth some lines # -- View this message in context: http://www.nabble.com/Multiline-Regex-with-Lucene-tp24667109p24667109.html Sent from the Lucene - Java Users mailing list archive at Nabble.com. --------------------------------------------------------------------- To unsubscribe, e-mail: email@example.com For additional commands, e-mail: firstname.lastname@example.com
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How do I calculate my gains and/or losses when I sell a stock?
To begin, you need to know your cost basis, or the price you paid for the stock. If you did not record this information, you should have an order execution confirmation and/or an account statement that covers the date of your purchase with the purchase price. Next, you determine the stock's selling price from an order execution confirmation and/or your brokerage account statement. The difference between the buying and selling prices is your gain or loss per share, which, when multiplied by the number of shares involved, gives you a total dollar amount for the transaction. If you want to further refine this number, you can add and subtract, respectively, the brokerage commissions related to the total stock purchase amount and the total stock sale amount.
Next, if the stock is in a taxable account (non-IRA or non-retirement), you will also have to consider the tax consequences. Under the current U.S. tax code., if you hold the stock for less than one year, the capital gain/loss will be considered as short term and will be calculated as ordinary income (loss) for tax purposes. If you hold the stock for more than one year and have a capital gain, it will, in most cases, be subject to the current beneficial capital gains tax of 15%. (To learn more, read A Long-Term Mindset Meets Dreaded Capital-Gains Tax.)
Let's look at an example of making a stock gain/loss calculation. Suppose that you buy 100 shares of XYZ stock on August 1, 2016, for $20 a share and sell 50 shares of this holding 13 months later on September 1, 2017, for $25 a share. On a per-share basis, you have a long-term gain of $5 per share. Multiply this amount by 50 shares and you have a long-term capital gain (15% tax rate) of $250 (50 x $5).
Investors need to remember that if a stock splits, they must also adjust their cost price accordingly. For example, if the stock purchase price was $25 and it split 2 for 1, the cost basis would be adjusted to $12.50 per share. (To learn more, see Understanding Stock Splits.)
Cymer, Tom
The first step to figuring out gains or losses would be to determine your cost basis of the stock in question. Your cost basis is typically what you paid for the stock plus add in any commissions/fees that you paid to acquire the stock. For example:
You bought 10 shares of XYZ stock at 100/share = 1,000
You paid a commission of 50 bucks to your broker/trade platform
Total paid = 1050 as your basis you can then divide by 10 shares you own = your basis per share
Next up you have to adjust your basis for dividends you may have gotten from the stock which were reinvested. So let's say your stock paid you $100 in distributions which you then paid tax on via a form 1099 DIV. You can now adjust your basis upwards:
1050 + 100 = New basis of 1150.
Finally you the difference in proceeds from the sale will be your gain or loss.
* The situation can potentially get trickier when you have stock splits that may have occurred or if you are working with stock that you inherited as well.
Follestad, Eric
Good Question, most firms provide a 1099 and gain loss summary at the end of the year, so you won't have to do this.
And most firms have a gain/loss tab for realized and unrealized gains/loss on their website.
If you're asking for a performance report type calculation, that's a more difficult question, but most RIAs should provide you with a report on a portfolio quarterly, discount brokers most likely won't have this feature.
Buy Price - Sell Price = Loss or Sell Price - Buy Price = Gain (excluding dividends). And this is a nominal return, it doesn't factor in inflation.


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We have a field of 14 women and seven men who either nominated themselves or were nominated by friends, and you can vote beginning Sunday for your favorite. We'll set up the winners on a date that we'll pay for (and chaperone, too).
See Sunday's Your Life section for photos of all the contestants, and see augustachronicle.com/living on Sunday for profiles of the contestants and your chance to vote.


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Best Of Jackson Hole.
Ski Corbet's Couloir, and if I survive, apre ski at the Moose, and then it's off for sushi at Nikais'. The perfect day!
This "Best Of" list is very subjective and will change often based on personal experience, reviews and your input. Some of the list is from personal experience and some is from the most popular rankings from review sites like Yelp.com, Tripadvisor.com etc. Send your comments and suggestions to me here.
|On The Mountain
|Best Of Jackson Hole - On The Mountain Lunch
|Casper Restaurant
Offers the largest variety of food and has some of the best fare on the mountain. Great views of the valley.
|Best Of Jackson Hole - Green Run
|Lower Teewinot
The green terrain is served by two dedicated lifts, the Eagle's Rest double and the Teewinot Quad. The green runs are gentle, and some go through the trees. The number of green runs is limited, and it's a big step from those green runs to Jackson Hole blue runs.
|Best Of Jackson Hole - Blue Run
It's one of the longest blue groomers on the mountain.
|Best Of Jackson Hole - Black Run
|Corbet's Couloir
Oh, this might be a little more than a black. If it's Jackson Hole it has to be Corbet's. Head down the tram to Corbet's Couloir. It's a very narrow and rocky chute that requires 10 to 20 feet of air to enter. Check out these three YouTube vids.
Someday, Somebody Will Ski That
Another Corbet's Victim
Corbet's Couloir (and the aftermath)
|Best Of Jackson Hole - Powder Run
|Hobacks - North, South & Middle
Steep, continuous fall-line skiing all the way down to the base of the mountain.
|Best Of Jackson Hole - Apre Ski
|Mangy Moose
Yalp.com - "Best apreski bar!!! Overcrowded, once or twice a week they have good bands or singers. For me that place allways fun"
"This is THE SPOT on the mountain to go and get some beers and decent grub. Ski to the door and stumble out hours later type of sitch. It is a very very busy establishment so it may take a while to find a seat and once you get a spot plant yer backside fer a min. and enjoy the grindage and drinks. Uniquely Jackson and a MUST SEE ! !
Tripadvisor.com - "You simply cannot visit Jackson Hole without stopping into the Mangy Moose. This is THE meeting place for great drinks, perfect bar food and/or a wonderful full dining experience. To say that the staff is friendly is an understatement and you'll be amazed at the service, even when the place is packed."
|Village Cafe
Yalp.com - "This is the local snowboard/freeski scene's joint for lunch and apres ski. Service ranges from surly to welcoming depending on the bartender's mood at the moment - don't take the surly personally. Saddle up to the bar, high five John Verdon and you'll be surrounded by ski/snowboard film stars, die hard shredders and the people who know where the good snow is."
"A great little cafe at base of the mountain. I've been here probably two dozen times over 15 or so years, and it's been good the whole time, and hasn't even really changed. It has an obvious indie vibe, seemingly aimed at the local boarder scene, but with no attitude directed towards outsiders and tourists."
|Best Of Jackson Hole - Music & Dancing
|The Million Dollar Cowboy Bar
Yelp - "Million Dollar Cowboy Bar is a country western bar with a live band that plays old and new country as well as some rock. For such a huge bar, the dance floor was kinda small and it was busy!"
Tripadvisor - "Classic cowboy bar decor down to the saddle bar stools. Small dance floor where we were able to two-step with the best of the locals. Live music, check the wedsite calendar for bands. Arrive before 6 PM to avoid the cover charge if you don't plan to make a night out of it."
|Mangy Moose
Yelp - "We were there two evenings. They had a more local band. We had to pay $15 cover charge. There was a lot of dancing. Last night MTHDS played. The cover charge was $8, but we were only charged $5 since we had dinner there. This band was much better...interesting songs."
|The Silver Dollar Bar
Yelp - "With live music on tap for the evening, the locals were taking turns on the small dance floor, entertaining the tourist crowds with their two step. Even with many small tables and a big bar, we were hanging in the over crowded standing room only for the rest of the evening. Fun times."
"Definately something of a tourist destination, and also clearly the local hangout spot for the over-30 crowd. But there's a nice big bar, plenty of seating, and it's a very chill location. Cool, old-west-style ambiance, and they've got live music a few nights a week too. But if you're under 30, I recommend going elsewhere."
|Best Of Jackson Hole - Breakfast
|Nora's Fish Creek Inn
Yalp.com - "I'm so glad I did my research, found out about this place, and drove the extra few minutes out of town to get to it. It's one hell of a breakfast! What a wonderful little hometown joint. But don't be fooled, everyone knows about it. It is absolutely packed!"
Tripadvisor.com - "In this expensive area near the Teton Village hotels, Nora's Fish Creek Inn had the best breakfast in the Rockies! You've got to try their Blueberry Pancakes when you go! Huge (the size of a plate) and delicious. What a treat each morning."
|Best Of Jackson Hole - Lunch
|Backcountry Provisions
Tripadvisor.com - "I'm from Philly so I know sandwiches, and these are good sandwiches. You can build a custom sandwich, and they really give you a lot of choices in what bread, meat, cheese, spread, and veggies you want. And you can add as many veggies as you please for no extra charge, and they have a huge list of choices."
Yelp - "We were looking for a casual place to stop at that was good with kids and just happened to find this place on a side street off the main drag. There was a constant stream of people either eating there or picking up to go orders and once we got our orders we knew why. The sandwiches were stacked with meat, not just one or two slices and tasted great. The staff was also very friendly and helpful."
|Best Of Jackson Hole - Hamburger
|Billy's Giant Hamburgers
Tripadvisor.com - "This little hole in the wall on the main drag serves the best burgers in the US. You can bring in beer or a drink from the bar next door! Don't miss Billy's if you're in Jackson."
"This place is awesome. No matter what time of day, there's always a crowd. The burgers and fries are great. The service here is even better. It is definitely no frills, but they're funny and creative, very friendly, and have great advice for places to try and places to skip. Don't miss this spot."
Yelp - "Incredible Burgers!! Styled after a 50's diner the menu was short and to the point. The beef was fresh and very moist. No frozen patties here!! Alcohol available at the Cadillac Grill (attached). The crew working was fast, funny and friendly. A must eat when in Jackson!!"
"If you like burgers, then you'll want to stop here if in Jackson, WY. It's not fast food. Burgers are big and juicy. I stop here everytine I'm in town."
|Best Of Jackson Hole - Dinner
Italian - Yelp - "What I really like is the food quality of the boutique style pizza, pastas, secondi and salads, which for the most part are really nice and flavorful. Osteria is a bright, fine(r) dining option right in Teton Village where the ski resort is. It's in gorgeous, hip Hotel Terra and one of the only non-western or Austrian kitchy dining options at the resort. The restaurant bases its menu on restaurants like Batali's Lupa in NYC. It's a fantastic hotel restaurant."
"Several nights' observation taught us to snag the best table: a fireside outdoor table. It was getting dark - and cold - by the time we got our main courses, so the fire was key to sitting outside. Inside was noisy chaos, but outside under the stars, by the fire was peaceful and romantic. I would have eaten there every night if I had known it was going to be this good!"
|Rendezvous Bistro
French - Yelp - "Don't exactly know what to say about this place outside of this: We'e gone two out of the last three nights. This place is legit. You could drop the food in the Bay or NYC and this place would hold up more than just fine. And in true Jackson fashion, you can find beautiful people here or you can find lifty locals. It suits all types and the food is excellent."
"The Bistro is the ultimate locals stand-by for date night, birthdays, dinner with friends and my first thought when going to dinner. The food is reliably good, interesting and not crazy, tourist trap expensive. It's French bistro done mountain-style with a raw bar twist."
|Nikai Sushi
Sushi - The best wild salmon sashimi I have ever had.
Yalp - "Being a local in Jackson, it is wonderful to have Nikai when I get a sushi craving [which is quite often might I add]... I have been to Nikai more than a dozen times and every single time I have gone, it has failed to disappoint me! This is a must try for sure if you're in Jackson. I know you're probably thinking, "but I want local color, Jackson food" well honestly, this is a restaurant that should be an exception!"
Urbanspoon - " Dining out in Jackson is like hopscotch: Nikai twice, Blu Kitchen once, Nikai twice, Blue Lion once, Nikai thrice, Rendezvous Bistro once...I'm telling you, don't bother skipping. I have never been disappointed with Nikai. Unmatched on all counts."


text:
WATCH: 50 Cent - Animal Ambition
With his new album out in stores today, 50 Cent keeps the visuals coming with the release of a new video for "Animal Ambition." 50 made a lot of headlines this past week when he reunited and performed with his original G-Unit partners for the first time since 2008 and announced that there would be new music from the crew.
CLICK HERE to buy 50's new album and Press Play below to hear G-Unit's "Nah I'm Talkin Bout" and watch the video for "Animal Ambition."
WARNING: Explicit Content
Source: 50Cent.com


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Me and two buddies went out at Java East, it was so rough, my buddies couldn't get out past the break. I managed to get out about 4 times,.....WOW.....intense. The waves were so huge, we were out past the peir, no joke some waves looked to be 8-10 ft. I surfed 4 of the biggest waves of my life. the drop in was so intense, sent butterflies in my stomach just catching them,.....what a rush.But honestly the water was too rough.We went to Springmaid peir, and some of the waves were crashing on the peir...CRAZY, but we are going to go back out Saturday & Sunday, hoping for nice waves.
Results 1 to 10 of 45
Thread: Tried to SURF
Hybrid View
Aug 22, 2008, 01:02 PM #1Junior Member
- Join Date
- Jun 2008
- Location
- North Myrtle Beach( windy hill)
- Posts
- 6
Tried to SURF
Aug 22, 2008, 01:30 PM #2Senior Member
- Join Date
- Apr 2008
- Posts
- 179
8-10ft, try 4 to maybe 6, you will know when you see 8-10 and it aint here unless that storm is right on top of us. Hate to have a lid in the pic, but this looks about a solid 10 : http://www.swellinfo.com/gallery/sho...php?i=419&c=21
Last edited by bfloyd; Aug 22, 2008 at 01:38 PM.
Aug 22, 2008, 02:16 PM #3
that pic is defiently a solid 10' it looks like.
Aug 22, 2008, 02:27 PM #4Member
- Join Date
- Mar 2008
- Location
- sc
- Posts
- 81
if you guys had trouble getting out yesterday then you might want to think twice before paddling out when we do actually get some hurricane surf.
Aug 22, 2008, 03:50 PM #5
I'd say over 6ft on some of the sets where I was yesterday, some of the drops were pretty long.
Aug 22, 2008, 04:06 PM #6
I went out this morning, I couldn't really get out past the break. As soon as I got into deep water the currents swept me south towards the pier. This was early, before the wind got too bad. I wound up bodyboarding the shorebreak for a while, then the wind got stronger and I couldn't even do that. Twisted my ankle on a takeoff 'cause the choppy waves twisted my fin around. The wind was so strong that the sand was blowing around like drifting snow in a blizzard.
It'd be nice if it cleaned up for the weekend, but the forecast says choppy.
Aug 23, 2008, 12:21 AM #7Member
- Join Date
- May 2008
- Location
- Myrtle Beach, SC
- Posts
- 52
Aug 22, 2008, 09:19 PM #8Junior Member
- Join Date
- Apr 2008
- Posts
- 16
wowwww. thats sad
i went out the past 2 days. it was rough and the current was bad. but if you cant paddle out with ease on a day like yesterday or today, that is pathetic.
you need to hit the gym.
it was like 4-6ft where I was at. some of the sets were lining up. otherwise it was complete chaos. very unorganized.
Aug 22, 2008, 09:51 PM #9
Man I haven't surfed in days because of Fay. I would go, but I'm stuck at home all day with no reasonable way to get to the beach.
I would go tonight just to go, but I caught with an invitation to the Ice House (skating). (Dang!). I like ice skating and all, but I like surfing better


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- Kitchen
- Kitchen Knives & Tools
- Knives & Knife Sharpeners Metallic/stainless Steel Knife Sharpeners
Metallic/stainless Steel Knife Sharpeners
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Stanniocalcin 2 alters PERK signalling and reduces cellular injury during cerulein induced pancreatitis in mice
Stanniocalcin 2 (STC2) is a secreted protein activated by (PKR)-like Endoplasmic Reticulum Kinase (PERK) signalling under conditions of ER stress
Since PERK signalling has both physiological and pathological roles in the pancreas, STC2 expression was assessed in mouse pancreata before and after induction of injury using a cerulein-induced pancreatitis (CIP) model. Increased
This study links STC2 to the pathological activation of PERK
The stanniocalcin (STC) family of secreted glycoproteins consists of two members - STC1 and STC2 - that have 35% conserved identity and conservation of exon/intron boundaries, indicating that they are paralogs
The UPR is activated when ER homeostasis is disrupted. Alterations to proper functioning of ER machinery arise when protein load exceeds folding capacity, such as when luminal ER Ca2+ concentrations are perturbed. The UPR consists of three signalling pathways that are individually transduced by ATF6, inositol-requiring enzyme 1 (IRE1) or PERK
PERK is expressed in the exocrine and endocrine pancreas under normal conditions
Given the relationship between PERK and STC2
To determine if PERK signalling is active in pancreatic tissue, we performed IF with an antibody that recognizes only the phosphorylated form of PERK (pPERK). The accumulation of pPERK was restricted to a tight apical portion of the acinar cells (Figure
Figure 1
STC2 accumulation increases in pancreatic tissue following induction of pancreatic injury
STC2 accumulation increases in pancreatic tissue following induction of pancreatic injury. (A, B) Immunofluorescence (IF) for pPERK (green) before (A) and 4 hours after (B) initiation of CIP. pPERK (arrowhead) localizes to the apical end of acinar cells under physiological conditions and more basally during CIP. Magnification bar = 13 μM. DAPI was used to counter stain nuclei. (C) RT-PCR of whole pancreatic RNA extracts from saline (S) and cerulein (C) treated mice showed increased accumulation of
These findings suggest that STC2 is co-induced with PERK in acinar cells only after injury and may protect the pancreas in response to CIP. To determine if STC2 could alter the acinar cell response to pancreatic injury, we examined a mouse model in which STC2 is constitutively expressed (
Figure 2
Overall morphology and differentiation does not appear to be affected in
Overall morphology and differentiation does not appear to be affected in
We next examined PERK signalling in
Figure 3
Systemic over-expression of STC2 (
Systemic over-expression of STC2 (
To understand why activation of PERK and eIF2α appear reduced in STC2
Alterations to PERK/ATF4 signalling should have an effect on cell autophagy, a long-term response to ER stress, which is regulated by ATF4 during hypoxia
Figure 4
The alterations in PERK signalling and cell autophagy suggested that
Figure 5
STC2 over-expression reduces severity of acinar cell damage during cerulein-induced pancreatic injury
STC2 over-expression reduces severity of acinar cell damage during cerulein-induced pancreatic injury. (A) Analysis of serum amylase levels four hours into CIP treatment show that serum amylase levels rise approximately 3 fold in WT mice when compared to saline (•) whereas the increase in
As a final marker for CIP severity, we assessed the amount of acinar cell necrosis and apoptosis within the two genotypes. The ratio of necrosis to apoptosis correlates to CIP severity
Figure 6
Cell death is decreased during CIP in
Cell death is decreased during CIP in
STC2 is a secreted protein that, when expressed to high levels in mice, has profound effects leading to growth restriction
Studies assessing the expression of
While previous studies have correlated increased expression of STC2 as part of the UPR, the effects of STC2 on PERK signalling have not been examined. We have now shown that systemically high levels of STC2 reduce PERK activation.
We have identified at least two effectors of the PERK signalling pathway that were changed in
In light of decreased PERK and eIF2α activation, it was surprising that increased accumulation of ATF4 was observed in the pancreas of
Figure 7
Schematic pathway showing a possible role for STC2 in affecting the PERK signalling pathway
Schematic pathway showing a possible role for STC2 in affecting the PERK signalling pathway. The increased accumulation of ATF4 leads to increased expression of GADD34, ATF3 and STC2. Elevated levels of STC2 can alter both PERK phosphorylation and ATF4 levels through as yet undetermined mechanisms (dashed arrows), as well as promote reduced damage during pancreatic injury. Whether this protective effect of STC2 is a normal function of the protein needs to be clarified.
As would be expected from increased ATF4 expression,
Whether STC2 is protective in nature is still unclear since studies have shown it has both protective
In conclusion, this is the first study to correlate PERK signalling and STC2
Mouse handling
For characterization of
Induction of pancreatitis
To induce pancreatic injury, 2-4 month-old female mice were given up to seven hourly intraperitoneal injections of cerulein (50 μg/kg body weight; Sigma-Aldrich). As a control, mice were injected with 0.9% saline. Mice were sacrificed 1, 4 or 8 hours after initial cerulein injection and pancreatic tissue from each was immediately processed to isolate RNA, protein, and tissue sections for histological or immunohistochemical analysis. To assess serum amylase, blood was obtained via cardiac puncture, placed on ice for 20 minutes and centrifuged at 4°C, 2500 rpm for 15 minutes. Serum amylase was quantified using a Phadebas amylase assay (Magle Life Sciences, Lund, Sweden) as per manufacturer's instructions.
Tissue preparation and histology
Pancreatic tissue was either directly embedded in OCT or incubated in formalin for 24 hours followed by paraffin embedding. For morphological analysis, paraffin embedded tissue was sectioned to 6 μM and stained with hematoxylin and eosin. Immunofluorescent (IF) analysis was performed on fresh frozen sections as described previously
Table 1
List of Primary Antibodies Used in Fazio et al (2011)
Santa Cruz Biotechnology (Santa Cruz, CA, USA)
Santa Cruz Biotechnology
Sigma (St. Louis, MO, USA)
Santa Cruz Biotechnology
AbD Serotec (Oxford, UK)
Transduction Laboratories (San Jose, CA, USA)
Connexin 32
Millipore (Temecula, CA, USA)
Invitrogen (Carlsbad, CA, USA)
total eIF2α
Cell Signalling (Beverly, MA, USA)
Santa Cruz Biotechnology
Novus Biologicals (Littleton, CO, USA)
Novus Biologicals
ProSci Incorporated (Poway, CA, USA)
Abcam (Cambridge, MA, USA)
Santa Cruz Biotechnology
Chemicon (Temecula, CA, USA)
1 - Abbreviations; IB, immunoblotting; IF, Immunofluorescence
TUNEL analysis
TUNEL analysis was used to identify apoptotic cells using the
RNA isolation, Northern blotting and Real-Time RT-PCR
RNA was isolated from the splenic portion of the pancreas and processed using TRIzol (Invitrogen, Burlington, ON, Canada) as described
For RT-PCR, two μg of RNA was reverse transcribed using Improm-II reverse transcriptase and random primers (Promega, Madison WI, USA). RT-PCR for
Protein isolation and immunoblot analysis
Protein extraction was carried out to obtain both nuclear and cytoplasmic fractions. Briefly, 5 volumes of buffer CE pH 7.6 (10 mm Hepes, 60 mM KCl, 1 mM EDTA, 0.075% v/v NP-40, 1 mM DTT, 1 mM PMSF) were added to whole pancreatic tissue prior to homogenization. Homogenized cells were centrifuged at 1000 rpm, 4°C for 4 minutes. The supernatant was removed and saved as cytoplasmic extract. The nuclear pellet was gently washed with CE buffer lacking NP-40 and centrifuged again. After removal of the supernatant, the nuclear pellet was covered with 1 pellet volume of NE buffer (20 mm Tris-HCl, 420 mM NaCl, 1.5 mm MgCl2, 0.2 mM EDTA, 1 mM PMSF, 25% w/v glycerol) and the NaCl concentration was adjusted to 400 mM for the entire volume. An additional pellet volume of NE buffer was added followed by vortexing for resuspension. The extract was incubated on ice for 10 minutes with intermittent vortexing. Both cytoplasmic and nuclear extracts were centrifuged at 14,000 rpm, 4°C, for 10 minutes to pellet any debris. Nuclear extracts were used for analysis of MIST1, PDX1, XBP1 and ATF4 levels, whereas cytoplasmic extracts were used for all other immunoblot analysis.
Electrophoresis and immunoblotting were carried out as previously described
Statistical Analyses
All statistical analyses were performed using Graphpad Prism 4.02 (Graphpad Software, San Diego CA, USA). Carboxypeptidase cleavage and serum amylase levels were analyzed using a two-way ANOVA followed by a Bonferroni post-hoc test. Levels of phosphorylated eIF2α and LC3 cleavage were statistically analyzed using a Mann-Whitney test.
Authors' contributions
EF carried out the animal studies, protein and gene expression analysis, performed the statistical analysis and drafted the manuscript. KK carried out some immunofluorescent analysis and SC performed Northern blot analysis. GD provided mouse lines and participated in its design and coordination and helped draft the manuscript. CP conceived the study, and participated in its design and coordination and helped to draft the manuscript. All authors read and approved the final manuscript.
The authors would like to thank members of the Pin and DiMattia laboratories, especially Charis Johnson, Christin Giller and Yudith Ramos-Valdes for their support and suggestions in these studies. This work was funded by operating grants from the Canadian Institutes of Health Research (CP - MOP 53083; GD - MOP 53128). C.P. is supported by a salary award from the CIHR. E.F. is supported by a doctoral research award from the CIHR/CDHF.
Stanniocalcin 2: characterization of the protein and its localization to human pancreatic alpha cells
Rainbow trout corpuscles of Stannius: stanniocalcin synthesis in vitro
Chum salmon (Oncorhynchus keta) stanniocalcin inhibits in vitro intestinal calcium uptake in Atlantic cod (Gadus morhua)
Stanniocalcin-2 is a HIF-1 target gene that promotes cell proliferation in hypoxia
Characterization of stanniocalcin 2, a novel target of the mammalian unfolded protein response with cytoprotective properties
Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response
Dissociation of Kar2p/BiP from an ER sensory molecule, Ire1p, triggers the unfolded protein response in yeast
Interconversion of three differentially modified and assembled forms of BiP
The dynamic role of GRP78/BiP in the coordination of mRNA translation with protein processing
The unfolded protein response
Identification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in translational control
Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase
Translational regulation of yeast GCN4. A window on factors that control initiator-trna binding to the ribosome
Activating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress response
Dimerization and release of molecular chaperone inhibition facilitate activation of eukaryotic initiation factor-2 kinase in response to endoplasmic reticulum stress
Delineation of a negative feedback regulatory loop that controls protein translation during endoplasmic reticulum stress
Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alpha
Pancreatic eukaryotic initiation factor-2alpha kinase (PEK) homologues in humans, Drosophila melanogaster and Caenorhabditis elegans that mediate translational control in response to endoplasmic reticulum stress
Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival
PERK eIF2 alpha kinase is required to regulate the viability of the exocrine pancreas in mice
Mice lacking the transcription factor Mist1 exhibit an altered stress response and increased sensitivity to caerulein-induced pancreatitis
Human stanniocalcin-2 exhibits potent growth-suppressive properties in transgenic mice independently of growth hormone and IGFs
Alcohol-induced protein kinase Calpha phosphorylation of Munc18c in carbachol-stimulated acini causes basolateral exocytosis
Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cells
Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress response
IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA
Calcineurin interacts with PERK and dephosphorylates calnexin to relieve ER stress in mammals and frogs
Regulation of autophagy by ATF4 in response to severe hypoxia
Apoptosis versus necrosis in acute pancreatitis
Impaired autolysosome formation correlates with Lamp-2 depletion: role of apoptosis, autophagy, and necrosis in pancreatitis
Release of chromatin protein HMGB1 by necrotic cells triggers inflammation
The murine stanniocalcin 2 gene is a negative regulator of postnatal growth
Stanniocalcin-2 promotes epithelial-mesenchymal transition and invasiveness in hypoxic human ovarian cancer cells
p300 modulates ATF4 stability and transcriptional activity independently of its acetyltransferase domain
The p300/CBP-associated factor (PCAF) is a cofactor of ATF4 for amino acid-regulated transcription of CHOP
ER stress (PERK/eIF2alpha phosphorylation) mediates the polyglutamine-induced LC3 conversion, an essential step for autophagy formation
The role of ATF4 stabilization and autophagy in resistance of breast cancer cells treated with Bortezomib
Stanniocalcin 2 expression is regulated by hormone signalling and negatively affects breast cancer cell viability in vitro
The bHLH transcription factor Mist1 is required to maintain exocrine pancreas cell organization and acinar cell identity
Mist1-null mice are resistant to streptozotocin-induced beta cell damage
Mist1 is necessary for the establishment of granule organization in serous exocrine cells of the gastrointestinal tract


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Have you guys watched this season of Project Runway All Stars? Despite having a mediocre start to the competition, winner of Season 12, Dom, won season 5 of PR All Stars. Once again she won based on the fact that she's literally the only designer that can make Fruit Salad actually look good on people. No one else can mix and match prints that are big, loud and bold like her. Take a look at her design for the iPhone case challenge:
If that doesn't scream FRUIT SALAD then I don't know what else to say. The judges knocked her for hand painting the leather. They are insane. It gives it that vintage DIY feel but also looks expensive as fuck.
What are your thoughts?


text:
Image Sensors World
News and discussions about image sensors
Sunday, November 27, 2016
LIPS Receives 2016 Golden Torch Innovation Award
LIPS receives
2016 Golden Torch Innovation Award from Outstanding Enterprise Manager Associate in Taiwan for the technologies behind its depth camera innovation.
LIPS Founder & CEO Luke Liu receiving award from the
former Taiwan's vice president Dwen-Yi Wu
Posted by
Vladimir Koifman
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What is JotForm?
JotForm is a free online form builder which helps you create online forms without writing a single line of code. No sign-up required.
At JotForm, we want to make sure that you're getting the online form builder help that you need. Our friendly customer support team is available 24/7.
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Andrea Roberts
|New York, NY
|v. +1.212.885.5568
|f. +1.917.591.9898
Andrea Roberts concentrates her practice on various litigation matters, including consumer finance litigation, real estate litigation, and contested residential foreclosure litigation. Ms. Roberts has extensive experience in conducting trials and traverse hearings, appeals, arguing motions in federal and state courts, representing clients at CPLR 3408 settlement and pre-trial conferences, and drafting and answering pleadings, motions, and discovery requests.
As a member of the consumer financial services team, Ms. Roberts works on a variety of consumer finance litigation matters, including disputes under TILA, RESPA, FCRA, ECOA and FDCPA, state law UDAP claims, and a variety of common law claims.
While in law school, Ms. Roberts was a member of the Pace International Law Review, and a judicial intern for the Honorable Anita Florio of the New York Supreme Court, Second Department.
- 2015-2016, "Rising Star" of Real Estate: Business in New York, listed in Super Lawyers®


text:
Couples Counselor
Tracy Schaperow, Psy.D.
Licensed Clinical Psychologist
567 Vauxhall St Extension, #207, Waterford, Connecticut
As a licensed clinical psychologist, my greatest emphasis for couples is working with people individually to address how they may improve themselves so as to improve the relationship. *Or*, I may help an individual learn more effect strategies to deal with challenging relationship struggles. My partner, a licensed marriage and family therapist, works with the couple in the room simultaneously. Those seeking this help may contact me, and I will let you know if your situation is something I can help with. If it is, we can proceed to schedule a first appointment. If it is not, I will help get you set up with my partner or another therapist who does the work you require.
Couples Counselor
Samuel Schaperow, MSMFT, LMFT
Licensed Marriage and Family Therapist, Psychotherapist
567 Vauxhall St Extension, #207, New London co, Waterford, Connecticut
When I was a student at UCONN, I learned of an article called "Bad Couples Therapy". I learned from it that many therapists who do family therapy do not have any formal training in couple therapy. How can this be? We don't have surgeons on the operating table without formal training in surgery, yet therapists can do it? Yes, it turns out the field of therapy isn't as regulated as one might think. Later in graduate school, I was able to get three full-time years of formal training in marriage and family therapy. The results I'm able to offer to people were well worth the extra schooling and residency I later completed.
Couples Counselor
Kevin Fleming Ph.D.
Coach/Change Agent/Consultant
Montauk, New York
What are the most common couples' issues? If you are thinking "communication, conflict, sex, money, child rearing" you are correct. However, most therapists will go after the symptom on each side of the couple fence thinking that the way to effective change is by getting each party to "work" on their respective "issue". Many times the parties don't agree but comply. Imagine if you could align the unconscious brains of a couple and stop the "working on your issues" part that has become so popular in therapy settings? Contact firstname.lastname@example.com to learn how! Or call 877-606-6161. DR. FLEMING'S NEW RELATIONSHIP/COUPLES INTENSIVES. www.kevinflemingphd.com/marriage-couples-retreats.php
06390 is a zip code located in Suffolk County and part of Fishers Island, New York. It has a land area of 4.056 square miles.  The population of 06390 is 236 people.


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Related terms for "tvoc detection ":
TVOC companies
Portable Gas & Indoor TVOC & Formaldehydes Analysers for the Ambient Air & Stack Emmission, Toxic Gas Detectors, Data Loggers.
based in Seoul, SOUTH KOREA.
Mobile computer based environmental test meters & monitors for IAQ, TVOCs, Toxic Gas, Air Velocity, Carbon Dioxide, Carbon Monoxide, %RH, Temperature, Particulate, Ozone, Ammonia, Hydrogen Sulfide, Nitrogen Dioxide, Formaldehyde, Differential Pressure, Barometric Pressure and other parameters. Log and document measurements easily and efficiently.
based in Shelton, CONNECTICUT (USA).
APC Techsafe is the market leader in gas detection equipment in New Zealand. With over 30 years of experience bringing the latest technologies from the world's leading suppliers to market, offering supply, service, calibration, training and support nationwide.
based in Avondale, NEW ZEALAND.
Ion Science Messtchnik produce high quality and innovative instruments for leak test, gas detection and corrosion monitoring. Our instruments meet the highest quality standards and can be used in diverse applications.
based in Mettmann, GERMANY.
SENSOTRAN was founded in 1990 by Mr. Joaquim Delgado, with more than 40 years experience in gas detection. We develop and manufacture detectors and gas detection systems for flammable and toxic gases, volatile organic compounds (VOC`s) and oxygen deficiency for personal safety, environmental protection and process controls. SENSOTRAN wide range of dependable sensors, ...
based in El Prat De Llobregat, SPAIN.
RAE Systems, Inc. is a leading global provider of rapidly deployable connected, intelligent gas and radiation detection systems that enable real-time safety and security threat detection. RAE Systems products are used in more than 120 countries by many of the world`s leading corporations and government agencies. RAE Systems offers a full line of wirelessly enabled ...
based in San Jose, CALIFORNIA (USA).
CitiSafe Pte Ltd offers services and solutions in regards to Industrial and Environmental safety and hygiene including gas detection, sound level meters, and calibration gases. We also provide rental and calibration services.
based in Singapore, SINGAPORE.
Specialists in Personal Gas Detection and safety we supply Handheld Portable Gas Detection Units, Personal Gas Alarms and Multi Gas Detectors for the trade and industry. Used for the detection of Flammable Gases, Oxygen Depletion and an extensive range of Toxic Gases meeting the safety monitoring requirements of a broad range of different industries. Whether your ...
based in UNITED KINGDOM.
Concept Controls Inc. manufactures and distributes gas detection, environmental monitoring and industrial hygiene equipment such as calibration gas, sorbent tubes, quality gas detection monitors and sampling pumps for the Canadian and international markets. Concept Controls Inc. is an innovative company offering a broad range of unique safety and instrumentation ...
based in La Porte, TEXAS (USA).
APL ASIA Authorized distributor in ASIA for Bacharach USA, Redtek USA, Calgaz USA, Telstar Spain APL has selected high quality products at a reasonable price to suit our customers. Bacharach Supply of instruments that detect, measure and record combustion, refrigerant and environmental gases, temperature, humidity and other air quality and safety parameters, A ...
based in Kookut, Lumlukka, THAILAND.
Teltherm has been in business for over 65 years and offers a multitude of instrument options. Teltherm is the proud distributor of many brands of instrumentation including pressure, temperature, calibration equipment, relief valves, flow, gas detection, level, burner safety and much more. We export, import, supply, manufacture, calibrate, certify and repair industrial ...
based in Onehunga, NEW ZEALAND.
Eideo Análisis, is a distribution company of instrumentation for analyzing and detecting different gases, thermography and related products. We have advice and technical service center, with an analysis lab for our products, giving service to the whole country. Formed by experienced professionals, puts together a group of technicians and collaborators, specialists in ...
based in Cornell de Llobregat, SPAIN.
Duncal Limited is a newly formed company supplying calibration, commissioning and installation services for fixed gas leak detection equipment. We are a new company coming to the market with a wealth of experience in this field. Director and Service Manager, Ian Dunlop, has been working in this field for the past 11 years with Murco Limited and is highly regarded by ...
based in Wicklow, IRELAND.
We specialize in the: Sales; Leasing; Repair Service; Training; Instrument Management; On-Site Service and Calibration; Calibration Services of portable and permanent gas detection instruments, photo-ionization detectors, industrial hygiene equipment, air sampling equipment, landfill monitors, water quality monitors, calibration gases and accessories.
based in Oakville, ONTARIO (CANADA).
PPM Technology is a leading manufacturer of portable and fixed gas detection and monitoring instruments, PPM has developed wireless connectivity for all our products; dedicated monitoring software enables our instruments to be managed wirelessly from a single PC; the collected data can be stored and analysed, analysis of the data can ensure effective management of any ...
based in Caernarfon, UNITED KINGDOM.
Respo Products with an ISO-9001 accreditation, is one of the leading suppliers and system integrators for Gas Detectors and Monitors in India like natural gas detector, portable gas detector, multi gas detector, fixed gas detector, wireless gas detector, etc. The company incorporated in 1992, has since progressed rapidly. Supported by a dedicated & efficient team, the ...
based in Agra, INDIA.
With over 80 years combined experience, Ribble Enviro is at the forefront of the gas detection market. Based in a beautiful countryside location near historic Clitheroe , the company has grown in stature through the provision of excellence - excellent service , excellent products and the building of strong customer relationships that brings customers back to us when ...
based in Gisburn, UNITED KINGDOM.
Levitt Fire Protection Systems offers a full line of fire protection systems and services that emphasize our commitment to quality service and technical knowledge. For over seven decades we have designed, installed, and maintained fire suppression and detection systems for leading industry clients. We look forward to putting our experience to work for you.
Novatech has been a leading supplier of analytical instrumentation and solutions including the measurement of gases and liquids for process, environmental and ambient detection. Our expertise allows us to understand and assess your needs, to recommend and offer the appropriate analyzers and integrated solutions that meet and exceed your expectations. We are exclusive ...
based in St Laurent, QUEBEC (CANADA).
Frontline Safety UK Ltd are a specialist provider of gas detection, environmental monitoring and safety equipment. We have access to over 20 different manufacturers and in excess of 4000 products available for purchase on the company website. Frontline Safety UK Ltd can also offer an extensive range of products for hire including single and multi-gas monitors, breathing ...
based in Glasgow, UNITED KINGDOM.
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|2,583 sq. ft.
|Property type
|Minimum Stay
|7 nights
Access direct from tarmac road no dirt traks here you enter the property through double wrought iron gates continue until you reach the second double gates where you will arrive to the rear of the property parking is arranged around a tall palm tree the space and ambiance will of already hit you that this is a very special villa, the large covered courtyard has a swimming pool, sun loungers, outside furniture, bar, TV, fridge and compliments, music system, Gas BBQ, cooking area with a array of el Fresco cooking facilities, there is a games area for horse shoe throwing, volley ball, etc, a dart board, and board games, flood lit gardens, stream with water fall and the entire property is fenced and secured, with night lighting it also has its own private walks. The inside of the villa is equally impressive with large spacious beautifully furnished rooms separate dining room, with large dining table, bay windows, high ceilings, large comfortable lounge 37m2, marble fireplace full c/h.
We are a English married couple and have lived in Spain for many years and bought our villa in 2003 from new, We fell in love with the area and just love the whole area surrounding Albox.
ANGELA purchased this villa in 2003
We were looking for a home that was in real Spain and came across this area stayed a while and simply fell in love with it
The villa is just how we wanted it to be Modern, spacious and over 240 m2 of build and very private, rural yet 2 minutes drive away from Albox Town centre giving you our guests the very finest holiday that a home can offer you.
Whether you are a couple, Family, or a large party you will be well catered for when choosing this upmarket spacious villa. it offers all mod cons, you can sing and dance the night away no neighbours to concern yourself with here the ultimate in private villa holidays
This villa is within walking distance from the main market town of Albox and yet it is set in some of the most glorious countryside you could imagine and the villa is probably unique in the fact that it has its own private walks set in some 3.5 acres of private land . and is ideal for bird watching and night star gazing no street lights here
The Villa exceeded our expectations with its spacious layout, wonderful pool and courtyard area, its privacy and the surrounding countryside. There are excellent un/commercialised beaches, hilltop villages and mountains all within easy reach. James & Family (June 2013)
We absolutely loved your villa and we were very sad to leave.
We did a few trips around the area but most of the time enjoyed the garden and pool. The kids, when not in the pool were behind the bar making juice cocktails, or playing the games. It was also great to get the kids to wind down to allow them to shower and then watch a movie before bed.
Kim & Family (July 2013)
From start to finish everything about this Villa is 5 star, Angela (owner) makes regular contact prior to the trip with little things like directions from the airport, local amenities, shops and restaurants etc. The friendly Andy and Sara meet and greet you as you enter Albox and escort you to the Villa, they then show you everything you need to know about the Villa and answer any questions you may have about the villa and local area. The Villa itself is beautifully clean and very well appointed, the covered terrace next to the crystal clear pool just makes the villa special. There are chairs and table to dine and a comfortable suite to relax the day and evenings away in total privacy and tranquility. The outside bar with fridge, gas and charcoal BBQs provide all you need for a fantastic holiday. The best recommendation I can give is that we will definitely be back in 2017.
The Orley's and Brownlow's, Sleaford,Lincolnshire.
We went to the villa for the last 2 weeks in September and had a wonderful time. It is very well equipped and comfortable but the highlight is the pool area. It is a great mix of sun and shade with a variety of seating and the perfect place for an evening BBQ which we had on a number of occassions. The villa and pool are also largely on the flat so great for people with any mobility issues.
The villa is also well situated to go out and visit the highlights of the area and close to the coast if you fnacy a sea swim of a meal on the beach. Also only 2 hours to Granada which is well other the trip.
The gardens are also lovely and the sunsets from the top of the neighbouring hill is worth the short climb.
I have no hesitation in reccomeding anyone to book this villa.
From stepping through the door it was evident that this was a home rather than a rental villa. We felt instantly relaxed and excited with the anticipation of the holiday to come.
The welcome pack was thoughtful and varied so much so we didn't venture out until the next day.
Andy and Sara were both welcoming and friendly and couldn't help us enough.
Communication with Angela was both swift and helpful she is a pleasure to deal with.
The biggest review we can give is that we have already booked for next year!!!
We had our second holiday in this fantastic villa in August 2016. Having had a great time the previous summer we didn't hesitate to book again. The villa is so well equipt, there is nothing that isn't to hand. Our holiday is centred around the pool and with the outside bar area (with fridge) comfy seats, TV, dining table, BBQ's and grill, our every need throughout the days and evenings were taken care of. We and our 3 young children spent every day in and out of the pool, then played games of table tennis and then back in the pool! The gardens are beautiful and offer several areas to dine 'Al Fresco'. Shops and supermarket are a 5 minute drive away but back at the villa you feel like you're a million miles away. Every evening we walked up through the beautiful gardens to the high hill to watch the sunset. The area is safe quiet and peaceful and we all had the most relaxing and enjoyable time. The owners representatives Andy & Sarah are so warm welcoming and friendly and instatntly make you feel at home!
We really can't speak highly enough of our holidays at this villa and will return without hesitation! It's perfect!!
We loved the villa as it has the feel of a home rather than a holiday let. The pool is a good size and looked after by Andy (who also does the meet and greet). Andy and his wife are on hand should you need them. My only criticism would be the fact that there are security cameras everywhere. I understand the need for security but you never knew whether or not you were being monitored. That aside this is a great villa and I would definitely go again.
What a fantastic holiday such a lovely property and very well maintained and very clean too.
Andy and Sara were great and very helpful
There was an issue with the pool as it was cloudy (Previous occupants had ignored the pool care rules) but Andy was very quick to sort it out and it was crystal clear in no time.
The kids loved the pool and the ample gardens (lizard hunting) and the sunset was epic every night.
I would definitely re-book
Special interest holidays:
Available for the following :
Special Birthday Parties, Anniversaries, Engagements, Etc.
Winter star gazing nights, breath taking clear skies, and cooking dinner over a real outside fire, and drinking local wine it does not get much better than this.
Walking and hiking throughout the low season here is just perfect with crystal blue skies.
Tranquility for those who just want to escape the rat race and have a more totally relaxed holiday together in a totally private property and its grounds. This villa is considered by many to be the best in the area.
Or Tailor made holiday breaks.
Make an enquiry for availabilities, details, and prices.
Mojacar garrucha
Mojacar is 35 mins away perched up on a hill side and is one of the most picturesque places you could ever imagine, with some fantastic beaches, seaside facilities, restaurants shops etc.
Garrucha is 30 mins away with top quality blue flag beaches and some of the finest fish restaurants on the south coast.
Car hire is essential. Almeria airport 1 hour drive, Alicante 1.75 hours drive, Murcia 1.75 hours drive.
There is a fantastic Indian restaurant and English shop 10 mins walk from the villa and the busy market town of Albox a further 10 mins walk or 2 mins drive, from the villa where you will find banks supermarkets, shops both Spanish and English, bars and restaurants serving a variety of foods from Spanish and English, to Chinese and Indian. A major out door market.plenty to keep you going emurse yourself in the Spanish way of life here
Further Details:
Most banks, supermarkets and the post office can be found 2 mins drive from the villa in Albox. indoor Bowling Alley, Horse riding is available, located just 10 mins drive on the outskirts of Albox . Quad bike 10 min away is also available another.
Mini Hollywood is 1 hour drive, where many famous films were made
The Magnificent Seven,Lawrence of Arabia, A Fistful of Dollars, a few dollars more, the good the bad and the ugly, Mad max, Indiana Jones and many more a fantastic day out.
|Rental Period
|Minimum Price
|Additional Nights
|Weekend Night
|Event Price
Jul - Aug 2017
1 Jul 2017 - 31 Aug 2017
7 night minimum stay
for 7 nights
Sep 2017
1 Sep 2017 - 30 Sep 2017
7 night minimum stay
for 7 nights
My Standard Rate
7 night minimum stay
for 7 nights
|No additional mandatory fees
|Refundable Damage Deposit
Booking Notes:
To Secure the villa for 1 week requires a 300 pound non refundable deposit and the balance is required 90 days before arrival.
To Secure the villa for 2 week's requires a 400 pound non refundable deposit and the balance is required 90 days before arrival.
A security damage deposit of 200 pounds sterling is required with the final payment this is refundable within 14 days of the end of the rental.
Changeover Day:
Rental Rates are subject to change until reservation is confirmed.


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28 noviembre 2007
Foster + Partners has allocated additional shares in the business and has promoted David Summerfield to senior partner. The announcement was made last night at the practices 40th anniversary celebrations, held at the British Museum.
The extension of the share ownership from 15 to 48 will give the opportunity for a further 33 partners to become shareholders, so broadening the shareholder base. This move is central to wider plans for the future expansion and strengthening of the company.
The first six months of the current financial year have shown continued growth, with the practice winning more design competitions in the last six months than in any previous year and staff numbers rising from 900 to 1200 in the same period.
Más información
Para más información, contacte con:
Katy Harris
Socia y jefa de prensa
Foster + Partners
E firstname.lastname@example.com


text:
Malaysia, a country situated in the Far East part of Asia, a tropical country very close to the equator, holds special importance to me. I was born and brought up in Tamil Nadu, a state to the south of India, which obviously brings out the question, how on earth is Malaysia close to me? Well, as you see, Malaysia has one of the highest settlements of Tamilians outside of Tamil Nadu, and despite me being a Malayalee from Kerala, Tamil Nadu holds more importance in my life as I grew almost up entirely in its borders and soaked up its culture; a very rich one indeed. So, I decided to make a trip to Malaysia and check out the places of interest and this is what I found.
KEDAH (Kadaram):
The State of Kedah, which was erstwhile known as Kadaram, was conquered by the Chola King of Tamil Nadu way back in the 11th Century AD. Having changed Governance over the years, the city is now a hustling and bustling commercial one and also houses the amazing island of Langkawi, one of the most coveted holiday spots in the world. A great place to unwind and relax, Kedah has a lot of goodies to offer tourists.
TAKAUPA (Takkolam):
This district, now a part of Thailand, is a part of the Malaysian peninsula and is also another Tamil bastion from the 13th century AD. It was said to have had the finest port in the Far East during the times of the Empire and its remains are still there for everyone to see. The heritage is preserved beautifully here. Truly, a must visit for history lovers.
One of the most iconic structures that are a prime example of the Tamil influence in Malaysia is the Batu Caves situated on the outskirts of Kuala Lumpur. Getting its name from the Batu River which flows past the hills, it has a 42.7 meter long Lord Muruga statue, one of the most worshipped Tamil God that stands majestically in front of the cave painted in Gold. The caves in themselves are mystical and this attraction has been visited by famous personalities worldwide including European football teams on tour and Presidents of various nations.
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text:
Peyton Manning plays (or is it played?) for the Indianapolis Colts.
As much of the NFL world waits to figure out the correct way to say that sentence, so does Peyton's little brother Eli.
In a nine-minute press conference in his big brother's city, Eli Manning spent much of his podium time fielding questions on his big brother.
He answered them, mentioning he won't be seeing his big brother much despite being in his city, but with only 30 second left in his press conference he slipped a little in his wording.
"I really haven't thought much about playing in Indianapolis," Eli Manning said. "It's not really a time to reflect right now on, on ... on that. It's just a matter of trying to get ready for the Patriots , trying to get ready to play this game, uh, getting prepared for their defense and we'll look back on, on the fact on playing in the Super Bowl in Peyton's uh ... in the town where he played his NFL ... uh ... plays, you know, plays for the Colts ... we'll look on that later."
And that, ladies and gentleman, is how the press conference ended.
(h/t Eye on Football)
Nate Davis is a reporter, blogger and editor who's been at USA TODAY since 2000. He has covered the NFL since 2005. No, he did not play quarterback for Ball State. Davis' succession of our esteemed colleague Sean Leahy at The Huddle is considered a Brady-for-Bledsoe swap by most "insiders."More about Nate


text:
Board index
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For example, how do you figure out a 3% concentration of your essential oil in 29 milliliters of carrier oil?Any and all questions by those needing a little help, and sharing by those who've been there :)
Sun Jun 18, 2017 9:01 am
Diffusing essential oils can be done for simple aromatic pleasure, or for one of several medicinal therapies. Do you want to diffuse anti-depressant oils, or maybe ones with potent antiviral or antibacterial properties?
Tue Jul 11, 2017 1:37 pm
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text:
Use of E-Cigarettes Soars, but Are They Safer Than Smoking?
Electronic cigarettes, or e-cigs, are battery-powered devices filled with flavored, nicotine-laced water that is inhaled as steam which is meant to substitute for the experience of smoking.
Often marketed a safe alterative to conventional smoking, these e-cigs in fact pose different health effects that are partially unknown and comparability unregulated.
In spite of the fact that the dangers are partially unknown, the use of these devices has skyrocketed in recent years. They have become particularly popular among young adults and teens who might not otherwise be using tobacco at all.
Its increasing popularity demands we take a closer look at what the health risks of this new trend might be.
The Report
According to 2014 Youth Tobacco Survey by the Center for Disease Control and Prevention, use of these "electronic cigarettes" among junior and high school students has tripled from 2013 to 2014. 13 percent of high school students use e-cigarettes, while only 9 percent smoke traditional cigarettes.
The number of teens who smoke cigarettes, pipes, and cigars is declining rapidly, yet at the same time, the number of teens who use any kind of tobacco product is increasing for the first time in years, largely due to the popularity of e-cigarettes.
Mass Appeal
Insiders in the e-cig industry claim that e-cigarettes are primarily used by people trying to quit smoking. In fact, the Youth Tobacco Survey reveled that cigarette use among teens has declined at its fastest rate ever, dropping 25% between 2013 and 2014.
While some people have expressed concern that e-cigarettes may serve as a "gateway" to smoking, it may instead be acting as a change of mindset. While there may be some merit to the claim that moving from cigarettes to vaping may be safer, it does not take into account the large number of people attracted to e-cigs when they would otherwise not be consuming nicotine at all.
Teenagers in particular have been effectively discouraged by education against smoking and consider it disgusting and un-cool, but are attracted to the trend of e-cigarettes due to its growing popularity, and the taste. Many E-cigs and vaporizers come with different forms of e-liquid in a wide variety of flavors, including tastes like fruit or candy that appeal to the young.
According to a young e-cig user interviewed by Sabrina Tavernise in a New York Times article published April 16, 2015, regular cigarettes have a harsh and "gross" flavor that's unappealing, but the sweet fruity e-cigarettes are far more popular. It also offers a mix-and-match set of accessories, allowing each individual user to call his or her own.
Uncertain Dangers
E-cigarettes still deliver highly addictive nicotine, but lack the tar and other dangerous chemicals of traditional smoking, so in that sense, may be safer than traditional cigarettes.
However, the Food and Drug Administration is only now beginning to take steps towards regulating e-cigs and studies are still inconclusive about what the long-term health effects of vaping may be. Dr. Margaret Hamburg of the FDA calls it "the wild, wild west," as products are coming out and evolving faster than researches can test their safety or regulate.
Analyzing samples of two popular brands, the FDA found that the level of nicotine in e-cig juice varies considerably from bottle to bottle, and that there are traces of carcinogens, cancer causing substances. This preliminary study supports their claim that e-cigs are not completely safe of the dangers of smoking, and should be treated with the same level of caution, warning, and regulatory oversight as other tobacco products.
A study from John Hopkins University published in Plos One February 2015 showed that mice exposed to e-cig vapor suffered damaged lungs and were far more likely to have respiratory infections.
More research needs to be known about the potential health risks, but until then, the safe decision would be to refrain from e-cigarettes. They are not a totally safe-alternative to smoking, and likely cannot provide the safe and effective way to quit smoking as medications with FDA approval.


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Marc Jacobs has mastered the fashion flip-flop like no one else. But abandoning Brigitte Bardot for Susan Sontag sounds wacky even by his standards. For Louis Vuitton's spring collection, Jacobs left fall's voluptuous retro beauty behind, lured not by the writer's sartorial style, but by her musings on camp, a snippet of which he tacked to his studio wall as he worked on the collection and then distributed to guests at his show. "The relationship between boredom and camp cannot be overestimated…" Sontag wrote, adding that camp taste is only possible "in societies or circles capable of experiencing the psychopathology of affluence." Hmm, doesn't sound like a compliment, to Vuitton or its customers. But Jacobs is nothing if not fearless, and who can deny that for those who love it, fashion is the ultimate antidote to boredom?
No ennui possible here as Jacobs went for flash, razzle and dazzle. He started with elements he called clichés of camp. Thus, the explosion of Chinoiserie, animalia, beading, fringe, prints, LV monogrammed lace, cheesy Art Deco and Art Nouveau riffs and color, color, color. His favorite dress is a bright, shiny-surfaced cheongsam, sometimes tasseled to the hilt, but a Thirties-ish riff on a Leonard print will do, too. And why go for mere zebra stripes when you can pair them with a giant zebra likeness on the back of a cape? Similarly, a white pantsuit provided a canvas for giraffe portraiture. And because he couldn't get enough of the animal motif, Jacobs sculpted the heels of his shoes — at LV, flats were so last season — after the legs of the afore-mentioned beasts. As for the bags — bright, highly decorated and fabulous.
Jacobs presented it all in an eight-minute whirlwind that served as a fashion Red Bull for his exhausted audience. It may not have been his most stellar or controversial outing for Vuitton, but it was playful, exuberant and glam, bam, thank-you ma'am. And a whole lot of fun.


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HI TIDE is burdened with a 7lb penalty for a really gutsy effort when beating Retrieve here last time but is going to prove tough to overcome if Aidan Coleman can cajole a similar effort from the Jenkins topweight. Dormouse and Larteta are both in current good nick but do seem close enough to the selection in the weights whilst course and distance winner, Dealing River, is respected but may just be stymied by the rise in the ratings for a couple of victories. Wester Ross should have blown the cobwebs away at Newton Abbot recently on a first run since August, whilst She's Late, likely to be popular due to connections, was easily brushed aside by No Substitute at Uttoxeter and will need to improve on this move into the handicap ranks, although he is only a 4-y-o with time on his side.
Hi Tide (IRE) 7-1 (11-10) In rear, headway from 2 out, soon went 2nd, stayed on to lead close home, won at Southwell 2m hcp hdl 0-115 (4) gd beating Retrieve (11-12) by hd, 5 ran.
Dormouse 9-1 (11-6) Held up towards rear, headway 5th, ridden approaching 3 out, went 2nd flat, no impression on winner, 2nd of 8, 4 1/2l behind Pure Style (11-10) at Worcester 2m hcp hdl 0-120 (4) gf.
Larteta (FR) 7-2 (10-9) Tracked leader, challenged 2 out, led between last 2, ridden before last, stayed on well, won at Stratford 2m nov hdl (4) gd beating A Tail Of Intrigue (11-5) by 2 1/4l, 4 ran.
She's Late 11-8fav (10-10) Tracked leaders, not fluent 3rd, led before 3 out, headed approaching next, well held by winner last, 2nd of 8, 20l behind No Substitute (11-0) at Uttoxeter 2m 4f mdn hdl (4) gd in Jun.
Wester Ross (IRE) 16-1 (11-11) Held up, kept on run-in, never going pace to get involved, 6th of 9, 12l behind Tamarillo Grove (11-3) at Newton Abbot 2m 1f hcp hdl 0-115 (4) gd.
Dealing River 4-1 (10-9) Tracked leaders, ridden and pressing for 2nd when blundered last, stayed on same pace, 4th of 8, 7l behind Pure Style (11-10) at Worcester 2m hcp hdl 0-120 (4) gf.


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By Steve Jones, USA TODAY
The envelope-pushing '70s band Labelle, beloved for its soaring voices, audacious lyrics, outrageous outfits, genre-busting sound and exuberant performances, often talked about getting back together.
But the demands of three solo careers kept Patti LaBelle, Nona Hendryx and Sarah Dash from anything but occasional small projects. A 2006 collaboration on Dear Rosa, a Hendryx-written tribute to late civil rights icon Rosa Parks, convinced them their time had come.
"I really wasn't feeling Labelle," says LaBelle, 64. "I was always loving us, but not knowing if we came back, if we would have the same sound. I was so pleased when I finally heard us sing. It's going to be awesome."
The threesome returned this fall with Back to Now, the group's first studio album in 32 years. They'll play their first full concert together in more than three decades Friday at Harlem's Apollo Theater and are planning a 2009 tour. Hendryx says that after years of working solo, they need rehearsals to get back into the swing of working as a group.
"All of us had been performing Lady Marmalade and other songs from the catalog on our own, so we got used to singing parts that we didn't sing," says Hendryx, 64.
The new album combines edgy political anthems and moving ballads. Two of the songs — the socially prickly System and soulful Candlelight— were written by Hendryx 30 years ago but recorded this year and produced by Lenny Kravitz. Wyclef Jean produced the anthemic first single, Roll Out. Philadelphia soul legend Kenneth Gamble produced three tracks and teamed with longtime partner Leon Huff on a fourth.
The album also includes Dear Rosa and an orchestra-backed live version of Cole Porter's Miss Otis Regrets, which was recorded in London in 1970 and features The Who's late drummer, Keith Moon.
Dash promises that the members of Labelle will be as fashion-forward as ever when they perform. They pored through designer sketches for ways to bring out their individuality.
"We have similar tastes, but a different way of presenting it," says Dash, 63. "I remember many years ago, we went shopping separately and we all came back with the same pair of shoes."
LaBelle laughs about their old ensembles. She says the new ones will still be stylish but age-appropriate.
"We are not going to fool ourselves and think we can still wear that silver spandex stuff we used to wear," she says. "We're not that crazy. Back in the day, we wore those crazy outfits to get your attention.
"And once you saw us, you'd say, 'Let's listen to these crazy women.' And we had something to say. It wasn't just about those outfits."
They scored their first top 40 hit as Patti LaBelle and The Bluebelles in 1962 with I Sold My Heart to the Junkman, and followed with such singles as Danny Boy, Down the Aisle (Wedding Song) and Take Me for a Little While. In 1967, fourth member Cindy Birdsong left the group to replace Florence Ballard in The Supremes.
They moved to England in 1970 and hooked up with Dusty Springfield's manager, Vicki Wickham. They returned to the USA the following year, having ditched the classic girl-group formula and shortened their name to Labelle. Their new sound was an energetic concoction of soul, funk, gospel and rock, and they explored controversial social and sexual themes.
Labelle became a critical and cult favorite with albums such as Pressure Cookin', Phoenix, Chameleon and Moon Shadow. The group's biggest hit was from 1974's Nightbirds, the iconic Lady Marmalade. Artistic differences began to splinter the group, which played its last concert in 1976.
"We didn't know we were going to stay apart for so long, but it was like a caged bird that had to be set free," Dash says.
In a way, Hendryx says, "I'm glad that we split up when we did. It allowed us to not become caricatures of ourselves, and going forward, I'd like to see us not be that."
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Dinner on the Deck
Whole Foods Market Dedham Culinary Center
Monday, July 28, 2014 from 6:00 PM to 7:30 PM (EDT)
Who's Going
San Francisco, California
London, United Kingdom
Florence, Italy
Event Details
On the menu: Roasted Beets with Tarragon Vinaigrette; Grilled Pork with Ras El Hanout & German Potato Salad; Chocolate Hazelnut Mousse with Macerated Cherries
Who doesn't love dinner on the deck, patio or really anywhere outdoors at this time of the year? Let's celebrate our New England summer with some tips for healthy grilling and preparing simple sides, all paired with some great wines for those hot summer nights. Join Healthy Eating Specialists, Lisa and Maureen, and wine buyer Martin, for a lively and interactive Health Starts Here cooking class!
About Cooking Live: Turn off the TV—we know you're watching cooking shows anyway—and let our Culinary Center chef guide you through new recipes and techniques! These classes will feel like watching your favorite chef on TV, except we're here to answer all of your culinary questions. The best part? You won't leave feeling even hungrier than when you walked in!
When & Where
Whole Foods Market - Dedham
300 Legacy Pl
Monday, July 28, 2014 from 6:00 PM to 7:30 PM (EDT)
Add to my calendar
Whole Foods Market Dedham Culinary Center
Founded in 1980 in Austin, Texas, Whole Foods Market (wholefoodsmarket.com, NASDAQ: WFM), is the leading natural and organic food retailer. As America's first national certified organic grocer, Whole Foods Market was named "America's Healthiest Grocery Store" by Health magazine. The company's motto, "Whole Foods, Whole People, Whole Planet"™ captures its mission to ensure customer satisfaction and health, Team Member excellence and happiness, enhanced shareholder value, community support and environmental improvement. Thanks to the company's more than 73,000 Team Members, Whole Foods Market has been ranked as one of the "100 Best Companies to Work For" in America by FORTUNE magazine for 15 consecutive years. In fiscal year 2012, the company had sales of $11.7 billion and currently has more than 340 stores in the United States, Canada and the United Kingdom.