text:
The 2016 Kooyong Clonale is a blend of Chardonnay from our Tuerong and Balnarring vineyards.
The grapes are gently whole-bunch pressed directly into French oak barriques (10% new), where fermentation takes place without inoculation. After fermentation, the wine is aged on lees (without battonage) for 10 months. It is bottled without fining and with minimal filtration.
September 2015 welcomed the beginning of budburst leading to a dry and warm spring. October was 3 degrees above the average temperature and El Niño affected the amount of rain we received. Vine vigour was controlled due to the lack of rainfall with the canopy generous and open. Fruitfulness was up from the previous vintage and flowering and fruit set occurred unhindered. Veraison commenced in early January.
The period between January and mid-March was warmer than historically usual and harvest began at the same time in February as recent vintages. Conditions remained very dry and warm throughout the harvest period, it was a compact vintage finishing in mid-March. The viticultural team worked steadily throughout harvest and delivered healthy and energetic fruit, with ripeness and acidity well balanced.
Aromatically pure and airy, the nose delivers notes of lime, green apple and white peach along with some subtle smoky reduction. The palate offers flavours of grapefruit and nectarine combined with a lovely texture that pushes towards a pithy finish.
Back in my Best Cellars days, I had a colleague/mate who would pretty much go through a six pack of this a week as his staffies, let alone the beer that was always sitting in the ice chest, ready for his necking pleasure. He just loved this stuff. It's been reliably good to drink over the years, even outside my buddy's approach to it. On target for a comfortable mesh of chardonnay fruit flavour and a racier acid line running through the wine. Sits well in glass with its green apple, nectarine, sandalwood and faint fern-herbal character. The palate is edgy in its texture, like a starched sheet, long though, and offers layers of fruit and gentle savouriness. Very pleasant stuff here.
90 points
Mike Bennie


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BBC Sport - Ireland coach Joe Schmidt explains Luke Marshall exclusion
Schmidt explains Marshall exclusion
- From the section Rugby Union
Ireland coach Joe Schmidt explains the reasons behind the exclusion of Luke Marshall in favour of Gordon D'Arcy for Saturday's Six Nations game with Wales.
"It's a six-day turnaround and some players had a bit of residual fatigue from the win over Scotland - Luke was one of those," said Schmidt.
The Kiwi added that skipper Paul O'Connell was fit and "mentally 100% ready to go"

subset: commoncrawl


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Choose Between Two Options
- $25 for one initial consultation and one life-coaching session (a $50 value)
- $39 for one initial consultation and two life coaching sessions (an $80 value)
During 45-minute sessions, clients meet one-on-one with coaches who help them talk through any difficulties or obstacles in their lives. Then, they work together to create action plans to overcome those issues and accomplish their goals.
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text:
Today's Devotional
Streams of MercyWhat steps can you take to adopt God's perspective on mercy?
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In May of 2008 I graduated from the River of Life School of Ministry and I am now the Assistant Director of the River of Life Healing Room Ministry here in Rusk. I came to the Lord when I was 18 years old. I had received a Bible as a graduation present and as I started reading it our of curiosity, God used it to show me my need for salvation and how to receive it. I have been delivered from fear and depression, and I have learned in recent years how to flow in the supernatural power of the Holy Spirit (I am still in the process of learning that). I believe God's goal for mylife is for me to advance His kingdom here on earth in every way I can. I have found that the secret of living a happy, successful life is to live a life of intimacy with God. That is what success actually looks like, no matter what I may be experiencing. By the way, I love to write, so I will write blogs on a fairly regular basis. I hope they are a blessing to you. If any of you need prayer for healing, let me know and I will have some people in our healing room ministry pray for you.


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Newcastle are preparing to bid a high £12M for Bournemouth midfielder Matt Ritchie, who Manchester United were rumored to be interested in half way through last season as the Red Devils looked to increase their attacking options.
Now it seems that Newcastle manager Rafa Benitez has zoned in on the impressive 26 year-old Scottish International and the Mirror is reporting Newcastle are in talks with Bournemouth on his transfer – and it could happen as early as this week.
Sky Sports is reporting a deal is close.
Matt Ritchie – reported keen to work with Rafa Benitez
BREAKING: Sky Sources: @NUFC in talks with @afcbournemouth over deal to sign Matt Ritchie. More here: https://t.co/P3FI8XgZeq #SSNHQ
— Sky Sports News HQ (@SkySportsNewsHQ) June 29, 2016
We understand Newcastle are also hopeful of having Matt Ritchie signed up next. It's close. Bournemouth looking for £10-12m for the winger.
— Keith Downie (@SkySports_Keith) June 29, 2016
The Mirror is reporting that Rafa Benitez wants to compete this deal before he allows Andros Townsend to sign for Crystal Palace for the release clause of about £13M in his contract.
The potential loss of Townsend is not being taken well by the Geordie faithful, who are disappointed with the apparent loss of the talented winger – including us.
The Mirror is reporting that Ritchie is keen to work with Rafa Benitez and join Newcastle United, even though that means dropping down to the Championship.
Top Belgian goalkeeper Matz Sels was signed today from Gent for around £5M (€6M) and Dwight Gayle is in Newcastle right now taking his medical in a potential £10M move from Palace.
It looks like the next one through the door after those two could well be Matt Ritchie.
Hope so.
Rafa had talked almost a week ago of having three to four deals very close to being completed.
Comments welcome.


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Industry News
Topic of the Month
Topics of the Month 2017
July 2017: Surgical lasers
June 2017: Physiotherapy
May 2017: Medical Market India
March 2017: Big Data and medicine
April 2017: Laboratory medicine: infectious diseases
February 2017: The eye
January 2017: Children and cancer
Topics of the Month 2016
December 2016: The human patient
November 2016: MEDICA 2016
October 2016: Networked healthcare
September 2016: Intraoperative Imaging
August 2016: Medical Industry Worldwide
July 2016: Sports and medicine
June 2016: Hospital hygiene
May 2016: The heart
March 2016: Paediatrics and neonatology
February 2016: Regenerative medicine
April 2016: Medical education and training
January 2016: Infectious diseases
Topics of the Month 2015
December 2015: The brain
November 2015: MEDICA
October 2015: Theranostics
September 2015: Wearables
August 2015: Nuclear medicine
July 2015: Cardiovascular disaeses
June 2015: Cancer and diagnostics
May 2015: Cancer screenings
April 2015: The informed patient
March 2015: Crisis management and communication
February 2015: Pathology
January 2015: The intestines
Topics of the Month 2014
December 2014: Ethics
November 2014: MEDICA 2014
October 2014: Orthopedics and physical therapy
September 2014: Intensive-care medicine
August 2014: Hygiene
July 2014: The Skin
June 2014: Sport & Medicine
May 2014: Mobile Health & IT
April 2014: Emergency Medicine
March 2014: Continuing Education
February 2014: Cancer
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Cancer: refined treatment with proton minibeams
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Cochlear implants: safe procedure thanks to surgical robots
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Project A.L.I.N.A: Training in the interdisciplinary emergency room
Pneumonia in Children: Ultrasound or X-Rays?
A new broom sweeps clean? The new EU Medical Device Regulation
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Healthy at work: "Occupational health management is a win-win situation"
Project TeleView – Telemedicine for refugees
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Nutrition: finding intolerances in the blood
Is the Russia crisis also a crisis for medical technology?
Video Background Reports
Light microscope ChipScope - a glimpse into living cells
Photochemical internalization – A new hope against bile duct cancer?
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07/19/2017: Microscope that provides a glimpse into living cells
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Monday, 11/14/2016
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Beijing HuayiHuilang Medical Instrument Co., Ltd. to distribute GA-mapTM Dysbiosis Test in China
Biohit Oyj
Beijing HuayiHuilang Medical Instrument Co., Ltd. to distribute GA-mapTM Dysbiosis Test in China
Biohit Oyj and Beijing HuayiHuilang Medical Instrument Co., Ltd. have signed an agreement for the distribution of the GA-mapTM Dysbiosis Test in China.
GA-mapTM Dysbiosis Test allows measuring of gut microbiota imbalance, dysbiosis. The test is particularly suitable for patients suffering from inflammatory bowel disease (IBD) or irritable bowel syndrome (IBS). The test reports the intestinal bacterial profile and balance of the microbiota, which helps guiding the treatment or changing the dietary habits in cases of imbalance. GA-mapTM Dysbiosis Test is CE-marked. Biohit Oyj has an exclusive right to distribute the test in Finland and China.
General Director Yisheng Fang, Beijing HuayiHuilang Medical Instrument Co., Ltd.: 'Dysbiosis causes not only gut diseases, but is associated with other health problems as well. However, there has not been any reliable diagnostic test like Biohit Dysbiosis test in China as yet. China has a large and potential market for Dysbiosis Test. We have started the registration process in China that is a prerequisite for the marketing authorisation of the test.'
CEO Semi Korpela, Biohit Oyj: 'Numerous studies have suggested the role of gut microbiota in gastrointestinal diseases, but the links between dysbiosis and IBS or IBD have been discovered only recently. Following the new agreement, Beijing HuayiHuilang Medical Instrument Co., Ltd receives the rights to distribute GA-mapTM Dysbiosis Test in China, which is an important market area for Biohit.'
Additional information:
CEO Semi Korpela, Biohit Oyj
tel. +358 9 773 861
Biohit in brief
Biohit Oyj is a globally operating Finnish biotechnology company. Biohit mission is "Innovating for Health" – we produce innovative products and services to promote research and early diagnosis. Biohit is headquartered in Helsinki, Finland, and has subsidiaries in Italy and the UK. Biohit Series B share (BIOBV) is quoted on NASDAQ OMX Helsinki in the Small cap/Healthcare group. www.biohithealthcare.com www.biohithealthcare.com/additional-information
Beijing HuayiHuilang Medical Instrument Co., Ltd. in brief
Beijing HuayiHuilang Medical Instrument Co., Ltd. (Huayi) is a professional medical device and IVD distribution company headquartered in Beijing, China. Huayi has a highly experienced sales team and well-established sales network in all regions of China. The company has cooperation with well-known clinical experts and doctors and a strong ability to promote sales. The customers of Huayi can be found all over China.
Exhibitor Data Sheet


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The 2010 Burundian elections are being held between the 21 May and the 7th September.
The Burundi Early Warning Election Project plans to leverage the mobile platform to develop an information system that will collect, analyze and report on real-time events during the 2010 Burundian elections.
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Tuesday 27 May 1952
It was Tuesday, under the sign of Gemini. The US president was Harry S. Truman (Democratic).
Scaramouche, directed by George Sidney, was one of the most viewed movies released in 1952
while The Caine Mutiny by Herman Wouk was one of the best selling books.
On TV people were watching China Smith.
But much more happened that day: find out below..
You can also have a look at the whole 1952 or at May 27 across the years.
Old Newspapers
Have a look at the old newspapers from 27 May 1952 and get them!
Which were the most popular movies released in the last months ?
TV Series
Which were the most popular TV series released in the last months ?
Find out your future
Get a FREE Numerology report based on the digits of 27 May 1952!
Wish him/her..
Historical Events
Which were the important events of 27 May 1952 ?
- Eutropius
- Mother's Day in Bolivia (Dfa de la Madre)
- Bruno, Bishop of Wnrzburg
- Hildebert
- Pope John I
- Saint Julius the Veteran
- Feast day of the following saints in the Roman Catholic Church: Venerable Bede
- Lag Ba'omer in Judaism (2005)
- Children's Day in Nigeria
Famous Birthdays:See famous people born on 27 May
- European Defense Community forms.
Music Charts
Which were the top hits in that special week of May 1952 ?
Top #2 songs in the USA
- Johnnie Ray - Walkin' My Baby Back Home
- Bigger The Figure - Louis Prima
Search For Your Ancestors
Subscribe to our Newsletter
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Genealogy: find out your family heritage
Which were the most popular books released in the last weeks ?
Remember when
What videogames would you be playing back in the days ?


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Emotions have, understandably, been running high in one of the strangest and most frustrating U.S. political campaigns in many years. An upset remains possible, but on the eve of the 2016 election, Hillary Clinton seems to be holding and even expanding a narrow but convincing lead over Donald Trump. Polls tightened last week, but with Trump behind in Florida and only tied in North Carolina, it would take a dramatic surge to get him to 270 electoral votes.
Trump's momentum during the past week may fall short of getting him to the White House, but it appears to have helped embattled Republican Senators. Vulnerable GOP incumbents in North Carolina and New Hampshire seem to have stabilized in the polls with small leads, and a pick-up in Nevada would make it hard for the Democrats to reach fifty senators even with expected wins in Wisconsin, Pennsylvania, and Illinois. The race for control of the Senate could ultimately come down to the open seat in Indiana, where Evan Bayh's campaign is having more trouble than many expected with GOP Congressman Todd Young. Trump's mini-surge may be critical to that race; the RealClearPolitics poll average shows Young with a razor-thin lead.
With the House likely to stay Republican, Americans are probably looking at two more years of divided government. Clinton won't have the mandate Obama had in 2008, when Democrats controlled both ends of Pennsylvania Avenue and used the opportunity to pass major domestic legislation, including the Affordable Care Act. Many Americans want divided government this time around—with neither Clinton nor Trump enjoying much public trust, hiring one gang of crooks to investigate the other probably looks like a reasonable strategy to many voters.
Both Republicans and Democrats are likely to look back on 2016 as a year of missed opportunities. Almost any GOP candidate would have outperformed Trump against Clinton; another Democratic candidate might have crushed Trump and led the Democrats to a congressional takeover as well.
On election night, we at TAI will be keeping our eyes open, first, for any sign that the Trump surge was stronger than the polls indicate. A better-than-expected Trump performance in North Carolina would suggest a closer race; New Hampshire is another bellwether state. Signs of a Trump wave there would suggest that we were in for a long night of nail-biting suspense.
Beyond that, we'll be looking at the Senate races. GOP control of the Senate means one kind of fight over Supreme Court nominees; a narrow Democratic majority could signal a fight over the future of the filibuster as the pressure on Clinton to appoint liberal justices would grow. Current Senate rules effectively require a supermajority to confirm Supreme Court justices; "nuking" that rule could lead to an even more dramatic ideological makeover of the Court, and would also polarize and poison relations in the Senate.
To recap: Florida, North Carolina, New Hampshire—if Clinton takes two of these East Coast states a Trump win seems almost impossible; if she sweeps them, the race is effectively over.
In the Senate, watch Indiana. A Bayh win there tilts the national playing field toward the Democrats; a Young win substantially increases the odds that the GOP could hold the 51 seats it needs for control. (Assuming a Clinton win nationally, the Democrats would only need 50 seats to control the Senate as the Vice President casts a tie-breaking vote.) Again, Florida, New Hampshire, and North Carolina could point the way. If the GOP sweeps these three Senate races, it has a solid chance to keep control. Losing two of the three would put the Senate almost out of reach; a Democratic sweep would be game, set, and match.


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The hurricane has left at least 1000 dead, according to Reuters. Haiti has started burying victims in mass graves as cholera spreads in the devastated southwest.
The hurricane has left at least 1000 dead, according to Reuters. Haiti has started burying victims in mass graves as cholera spreads in the devastated southwest.
The hurricane was the strongest to hit the Caribbean in almost 10 years. It hit the developing nation a week ago with 145 mile-per-hour (233 kph) winds and torrential rains that left 1.4 million people in need of humanitarian assistance.
The country, with a population of about 10 million is the poorest in the Americas. The official death toll sits at 336, while officials visit each village to confirm the numbers.
Reuters reports it had been quoted various numbers in different areas from officials, which the news agency tallied.
It was quoted 522 people dead in Grand'Anse. A tally of deaths reported by mayors from 15 of 18 municipalities in Sud Department on the south side of the peninsula showed 386 people there. In the rest of the country, 92 people were killed, Reuters found.
The UN Children's Fund (UNICEF) has expressed concerned about the threat of waterborne diseases to children living in the worst-affected areas.
"Hundreds have died. At least 1.4 million people need assistance at this time. Some towns and villages have been almost wiped off the map. Crops and food reserves have been destroyed. At least 300 schools have been damaged," UN Secretary-General Ban Ki-moon said.
He said the numbers of those impacted and the needs are growing as more affected areas are reached.
Moreover, tensions are already mounting as people await help. "A massive response is required," he said, adding that UN teams are working with local officials to assess needs.
The $120 million appeal will go towards covering the UN system's needs for the next three months. Most of it goes to food security, nutrition and emergency agriculture.
According to the UN Office for the Coordination of Humanitarian Affairs (OCHA), the appeal targets vulnerable groups in identified priority sectors, and it takes into account the national-level capacities and those of humanitarian partners on the ground.
UN Emergency Relief Coordinator Stephen O'Brien said funding of the appeal is urgently needed to enable humanitarian actors to respond to people most in need before the situation further deteriorates, including by addressing the risks posed by cholera and other deadly waterborne diseases.
"Families that were fortunate to survive the hurricane now find themselves in a struggle to survive, with thousands of homes and livelihoods washed away by the storm," he said, recalling that the country was already facing health challenges, including an increase in cases of cholera as well as severe food insecurity, before the hurricane hit.
Meanwhile, UNICEF has warned that overflowing rivers, stagnant waters, and animal and human corpses are perfect breeding grounds for waterborne diseases. "Every day that goes by increases the threat of cholera. We are in a race against time to get to these children before diseases do," Marc Vincent, UNICEF Representative for Haiti, said in a press statement.
The country has of the highest incidence rates of cholera in the world, almost 10,000 people have died from the disease since 2010 and more than 27,000 suspected cases have been reported so far this year, an estimated one in three of them children.


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Ashley Greene – DKNY Behind the Scenes Videos
Check out the always gorgeous Ashley Greene in these behind the scenes videos of her DKNY campaign.
Breaking Dawn Cast Set Interviews
Robert Pattinson Bill Condon Kristen Stewart Taylor Lautner Jackson Rathbone Nikki Reed Peter Facinelli Elizabeth Reaser Ashley Greene Stephenie Meyer Wyck Godfrey Melissa Rosenberg Source: Screenslam
Ashley Greene and Robert Pattinson in Paris for Breaking Dawn Promotions
Robert Pattinson and Ashley Greene are in Paris at a fan event for Breaking Dawn Part 1. Rob was spotted wearing Dolce & Gabbana and...
ET Behind The Scenes Exclusive of Breaking Dawn Wedding and Honeymoon
Check out this video of behind the scenes of Breaking Dawn!! Source: Spunk-Ransom
Anna Kendrick on Unscripted With 50/50 Castmates
This is an awesome interview with Anna Kendrick, Seth Rogan and Joseph Gordon Levitt.
Kristen Stewart on Set of Snow White
Check out Kristen Stewart in costume on set of Snow White and the Huntsman :) Source: TodoTwilightSaga
Bryce Dallas Howard on Conan
Bryce Dallas Howard appeared on Conan O'Brien to talk about her new film 50/50.
Taylor Lautner on Jimmy Fallon
Taylor Lautner appeared on Late Night With Jimmy Fallon last night to promote Abduction. Check it out! Source: TodoTwilightSaga
Taylor Lautner on The Today Show
Taylor Lautner was on the Today Show earlier this week where he talked about his movie "Abduction".
Kristen Stewart in New Marcus Foster Music Video
Kristen Stewart is making her music video debut in "I Was Broken," the first single from Marcus Foster's debut album, Nameless Path, which drops September...
Kristen Stewart in W Magazine
Here's a portion of the interview with Kristen Stewart: Did you have a particular interest in vampires? All young girls like vampires. I f***ing love me...
New Trailer for 50/50 Featuring Anna Kendrick and Bryce Dallas Howard
Check out the new trailer for 50/50. This movie really has an all star cast and looks pretty good! Source: Yahoo! Movies
Bryce Dallas Howard on The Tonight Show
Bryce Dallas Howard appeared on The Tonight Show with Jay Leno on August 8th to discuss her new film The Help.
Official Bel Ami Trailer
FINALLY!! A trailer for Bel Ami, Rob's highly anticipated movie! Source: Spunk Ransom
Press conference from ModOration


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piglet jotter is a tree data store, in the thread of kjots but using GTK. It stores an arbitrarily deep tree, with data stored in the same hierarchy in a single directory as plain text. It can handle exporting to HTML. It is simple to use, install, and modify.
|Office/Business News/Diary
Release Notes: This release deals with directories better. It has better HTML output. TeX output [currently not active] has been added. There is some code cleanup and minor bugfixes.
Release Notes: Minor feature and usability enhancements.
A Fluent OpenStack client API for Java.
A TWiki appliance that is easy to use and lightweight.


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Erythropoietic neuroprotection: Holy Grail or potential to fail?
- First Online:
- Received:
- Accepted:
In this issue of Intensive Care Medicine, Simon et al. [1] report that pretreatment with a carbamylated erythropoietin fusion protein (cEPO-FC) is as effective as recombinant human EPO (rhEPO) in ameliorating spinal cord injury in a well-established porcine model of acute spinal cord ischemia and reperfusion. This new fusion protein contains two rhEPO molecules connected by the Fc region of human IgG1. Subsequent carbamylation of the EPO molecule is thought to improve the cytoprotective effects, while reducing side effects including hypertension and thrombosis [2].
EPO and EPO variants
Since the human EPO gene was cloned in 1985, several variants of the EPO molecule have been developed to improve its pharmacokinetic and pharmacodynamic characteristics and to separate its hemopoietic and neuroprotective properties [3]. Epoietin alpha and beta are rhEPOs and have minimal differences in their structure. A variety of EPO derivatives, including cEPO-FC, which target the erythropoietin receptor (EpoR), and mimetic compounds (such as EPO-peptide AB, helix B peptide and hematide) have been developed. Darbepoietin alpha is a hyperglycosylated analogue of EPO with a four- to fivefold lower erythropoietin receptor binding activity but a threefold longer serum half-life. Epoietin delta has been produced in a human cell line and has a human-type glycosylation pattern. CERA is a PEGylated form of epoietin beta with a long in vivo half-life. In addition, there are alternative means of enhancing endogenous EPO translation by preventing hypoxia-inducible factor-α degradation or GATA2 inhibition, thereby inducing endogenous EPO gene expression.
What is the cellular mechanism of EPO-induced neuroprotection?
EPO binds a transmembrane homodimeric cytokine I type EpoR complex. EPO and its receptor have been found in hematopoietic and several non-hematopoietic tissues including central nervous system, endothelium, cardiac myocytes, kidney, liver and some solid cancer cell lines [4]. Upon binding with EpoR an intricate series of intracellular signaling pathways are activated via Janus kinase 2 (Jak2) which increases the activity of intracellular mediators including signal transducer and activator of transcription 5 (STAT5), phosphoinositol 3 kinase (PI3K), mitogen-activated protein kinase (MAPK), extracellular signal-regulated kinase (ERK) and nuclear factor kappa B (NF-κB) [5, 6, 7]. These signaling pathways may promote neuronal survival by a number of putative mechanisms including: (1) neuroprotection, (2) neurogenesis, (3) antiinflammation, (4) angiogenesis and stabilization of neurovascular function, and (5) reduced oxidative stress. The primary endogenous sources of EPO within the central and peripheral nervous systems appear to be astrocytes and Schwann cells, respectively [8]. These cells release endogenous EPO in a paracrine manner that can affect neuronal survival. By contrast, exogenously administered rhEPO must cross the blood–brain or blood–spinal cord barrier to gain access to the central nervous system, as shown by a number of experimental studies. This has raised the possibility that exogenously administered rhEPO could have a neuroprotective effect in patients suffering from neuronal ischemia.
However, other recent studies have raised questions about the pleiotropic potential of EPO. Swift et al. [9] found that EpoR protein was barely detectable in 66 human tumor cell lines and EpoR signaling in response to rhEPO was not detected in non-erythroid cells. In another related study, surface EpoR was not detectable on the surface of endothelial, cardiac, neuronal or renal cells and there was no evidence of intracellular signaling induced by erythropoiesis-stimulating agents (ESA) despite the addition of very high doses of rhEPO [10]. ESAs did not reproducibly provide cytoprotection to neuronal, cardiac or renal cells or promote angiogenesis in vivo. However, some have postulated that the tissue-protective properties of rhEPO are dependent on the activation of an alternative receptor complex, a heterodimer consisting of EpoR and the common beta receptor [11].
What is the relevance of this study?
While previous experimental studies have demonstrated the efficacy of cEPO with respect to alleviating spinal cord injury and improving functional outcomes [6], the current study expands upon this finding by demonstrating that cEPO-FC is as effective as rhEPO in a balloon occlusion model of spinal cord ischemia–reperfusion in pigs. This model has a high degree of clinical relevance since it is applicable to the mechanism of spinal cord ischemia and reperfusion that occurs due to aortic cross-clamping during aortic aneurysm repair. In this clinical scenario, pretreatment with rhEPO may alleviate the risk of spinal cord injury due to subsequent aortic cross-clamping. The current study assessed short-term outcomes including motor evoked potentials and histological damage. Future studies will need to focus on the longer term neurological outcomes and demonstrate an absence of systemic toxicity, including thrombosis.
Can treatment with cEPO-FC improve neurological outcome without adverse systemic effects?
In experimental studies, carbamylation of the EPO molecule reduces the binding potential for the erythroid receptor, which is responsible for erythropoiesis, but maintains binding and efficacy at the tissue receptor, which is thought to be responsible for activating cytoprotective mechanisms [6, 11]. Therefore, cEPO-FC may provide a cytoprotective capacity in the absence of the toxicity associated with systemic EPO therapy. The importance of this potential is emphasized by the paradoxical findings of recent clinical trials with rhEPO: (1) normalizing hematocrit with rhEPO does not necessarily improve survival; [12, 13, 14]; (2) high-dose rhEPO is associated with increased thrombosis [13, 15, 16, 17]; and (3) in some patient populations (trauma) low-dose rhEPO may improve survival without affecting hematocrit [18]. In addition, early clinical trials produced interesting results in relation to the treatment of stroke [7, 11].
These clinical studies raised the possibility that rhEPO could improve important clinical outcomes including neuronal recovery and survival. However, the appropriate timing, dose and formulation of rhEPO are required. To date, human studies have not established a protective role for rhEPO. In the German multicenter stroke trial, rhEPO failed to show any clinical benefit in terms of the Barthel index, modified Rankin scale and NIHSS on day 90, or MRI parameters [19]. Indeed, the mortality rate in the patients receiving rhEPO was higher than in those receiving placebo, especially in those who had been pretreated with thrombolysis. rhEPO has also been investigated in the setting of myocardial ischemia and reperfusion where basic science studies also suggested a cardioprotective role. However, in a recent multicenter human study in patients with acute myocardial infarction, rhEPO failed to reduce the infarct size, but was associated with an increased rate of adverse cardiovascular events [20]. Thus, much further preclinical and clinical research is needed to determine if derivatives of rhEPO such as cEPO-FC can improve long-term neurological outcome without potential side effects including hypertension, thrombosis and mortality.


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LINCOLN, Neb. - Nebraska might be getting healthy a little too late.
The Huskers are now 2-4 on the season and a chance at a Big Ten West division title is out the window. But, a bowl game is very much a possibility and Nebraska appears to be getting healthy to make second half run.
Linebacker Josh Banderas, who has only played in two games with a groin injury, is expected to practice on Monday. The same can be said for Daniel Davie, who is also battling a groin.
Nebraska head coach Mike Riley listed defensive tackle Kevin Williams (thumb) and Michael Rose (groin) as questionable. In addition, linebacker Chris Weber is day-to-day with a strained neck.
It wasn't all good news for Nebraska. Starting offensive tackle Nick Gates, who left early against Wisconsin, has a high ankle sprain and is listed as out for Saturday's contest against Minnesota.


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Mermaid Rescue
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Doctor insights on:
Blood Spots On Skin
Tiny blood spots on skin (about the size of a pin head or smaller, on face above lip). What are they, why are they here & how do I get rid of them?
Don't know: This can't be diagnosed with the information that is available. A history, physical examination & other studies may be needed to determine cause/causes. Once accurately assessed a treatment plan can be developed. ...Read moreSee 1 more doctor answer
So on my right arm i have small flat blood spots under skin. My dr called them petechiea. She wasnt concerned but its freaking me out!
Learn more: Instead of being scared, you should gather more information which will reassure you and take away your anxiety. If you have spots only on your arm(not all over especially on the skin of your legs, you do not have petechiea(unless you had your BP checked on your arm area. If you hahve any further concern(or these get worse) get your bloods counts(CBC Platelet counts) done to be sure they are normal ...Read more
28f.Shooting/throbbing/burning pain rside/back.No taste, major stomach cramps, headaches, fatique, swelling.Blood spots under skin come/go.Is it serious?
May not be but you: May not be but you need an evaluation. It could be chest, abdomenal , neurological or vascular. ...Read more
I have raised blood spots on my skin. What are they?
Hemangioma: Assuming they've been around a while i suspect these are cherry hemangiomas. ...Read more
I am getting blood spots under the skin on only my left arm. They appear suddenly and fade away in about 10 days. What causes them?
Doctor can evaluate: Blood spots on the skin are called petechiae (purpura if they are bigger splotches), and are due to blood cells leaking out of the tiny blood vessels in the skin. After the blood cells have leaked out, the area behaves just like a bruise (the body breaks down the blood cells into different colored pigments, and carries them away over a week). The Dr. wants to find out why blood cells were leaking. ...Read moreSee 1 more doctor answer
I have tiny little blood spots under my skin on my legs and chest iam 25 and female what does this mean?
Angiomas?: Hard to say without seeing them, but i suspect that they are cherry angiomas, which are like moles except that they are made of small blood vessels. They are harmless - if that is indeed what they are. You really should have a dermatologist look at them in person, so that you'll know for certain what they are. ...Read more
The bites from the pubic lice causing blood spots on my skin?
Should go away soon: These could just be hyper allergic response to lice. After lice treatment, these should fade away in a week or so. If not, let your doctor examine it for a better assessment. ...Read more
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Get checked: It sounds like you are describing cherry angioma, a benign blood vessel growth that is very common. However, i advise any time seeing something new or changing on your body go get it checked by your dermatologist. ...Read more
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Blood spots: These could be small collections of blood vessels under the skin, cherry angiomas. These are entirely harmless and quite common. ...Read moreSee 1 more doctor answer
Blood spots rash under skin on left breast at the bottom and it itches a little. I am scared to death. Can this be breast cancer?
Probably not: This sounds more like a heat rash or contact dermatitis and not cancer. However, if it does not resolve quickly, you should see your physician. You are young but inflammatory breast cancer typically presents as a skin redness and inflammation and can progress rapidly. ...Read moreSee 1 more doctor answer
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Such question will be answered on this thread http://www.jotform.com/answers/775641


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Mary S. Brown Memorial-Ames United Methodist Church and Turner Cemetery are located at 3424 Beechwood Boulevard, right on the border between the Squirrel Hill and Greenfield neighborhoods of Pittsburgh, PA 15217. Click on the "About" link for contact information. For more information about the church and cemetery, scroll down this page.
The date for the Ninth Annual Turner Cemetery History Walk has been set for September 30, 2017, and it promises to be a very special occasion. Squirrel Hill resident and Squirrel Hill Historical Society member Eric Marchbein has applied for and was successful in getting a Pennsylvania Historical & Museum Commission roadside marker for Simon Girty, the complex and controversial man who originally claimed and owned 140 acres of what is now Squirrel Hill and Greenfield, including the land Turner Cemetery is located on. When Simon Girty and two of his brothers decided to fight on the British side in the American Revolution, he forfeited his claim to the land, and his half-brother John Turner eventually became the owner.
The cast metal historical marker will be placed on a pole on the sidewalk beside the cemetery. The dedication ceremony will be the main event of the History Walk this year, followed by speeches by historians, politicians and other dignitaries. The gaining of a state historical marker is a major achievement for both Greenfield and Squirrel Hill, the only one in the area, and well worth celebrating.
The History Walk will also include the usual activities–historical displays, an encampment of military re-enactors from the 8th Pennsylvania Regiment, bookstore, and food, of course. Make plans to come! The History Walk will take place from 11-3. Further details will be posted on this website as they are finalized.
A new book from the Squirrel Hill Historical Society will be released in June 2017. It can be preordered online at arcadia.com or amazon.com. Books will also be for sale at the History Walk for $22, with no tax or shipping costs. The History Walk "bookstore" will also feature other books by local authors.
Squirrel Hill: A Neighborhood History
Four members of the Squirrel Hill Historical Society has been engaged in writing a history of Squirrel Hill, which will be published by The History Press. The book contains chapters on the early development of Squirrel Hill, including the story of the Girtys, Turners, and their friends and neighbors. The book is scheduled to be released in June 2017. It will be available at most Pittsburgh bookstores and at amazon.com and other online booksellers.
Todd and Helen Wilson collaborated on the book, Images of America: Pittsburgh's Bridges. It is part of Arcadia Publishing's Images of America series, filled with photographs and other illustrations. Pittsburgh's Bridges presents a history of 144 bridges within Pittsburgh's borders, including those around the area where Turner Cemetery and MSBA Church are located. The book shows the sequence of bridges at various sites and explains the reasons behind their unique designs. The book was released on October 26, 2015. For more information or to order, go to amazon.com or click on this link: http://www.arcadiapublishing.com/9781467134248/Pittsburghs-Bridges
In the spring of 2014, Ken Girty, descendant of Simon Girty's brother Thomas, whose half-brother was John Turner, visited the cemetery and gave a talk in the church community room about his family's turbulent history. Unlike the other Girty brothers Simon, George and James, Thomas remained loyal to the United States during the Revolutionary War. After the war he moved a bit north and established a trading post at Girty's Run, buying land and eventually owning most of what is now Oakmont. The Girtys were half-brothers to John Turner.
A few weeks after his visit, Ken Girty invited the North Hills Past Finders to come to Turner Graveyard with an assortment of metal detectors to examine the graveyard for artifacts. The major find was an ax and possibly a chisel dated to between 1850-1860. Several churches were built on the site beginning in 1842, so it is possible the tools were used to build or maintain one of the structures.
We received the results of the Mercyhurst study of Turner Cemetery. As expected, the fluxgate gradiometer (magnetometer) scans showed anomalies that could mean burials, and, also as expected, most of the anomalies did not correspond to the present locations of the tombstones, since we knew they were moved around through the years. We are hoping Mercyhurst returns to study the upper half of the half-acre graveyard. We are also trying to find a way to have ground-penetrating radar scans done, which are more accurate. We have no plans to do any excavations in the graveyard. We would just like to mark the graves to honor those buried there.
Click on this link for the Turner-Mercyhurst Press Release.
Click on this link to see the article about the Mercyhurst study that appeared in the Pittsburgh Tribune-Review on May 6, 2013.
Here is some general information about the Turner Cemetery/Mary S. Brown-Ames Historical Site.
Turner Cemetery and Mary S. Brown Memorial-Ames United Methodist Church are located at 3424 Beechwood Boulevard on the border between the Squirrel Hill and Greenfield neighborhoods of Pittsburgh. The Turner Cemetery/Mary S. Brown-Ames Historical Committee (TC/MSBA) is researching the site because of its historical and genealogical importance. The cemetery dates to 1785 and provides information about many of the earliest settlers of Squirrel Hill. The adjacent church was built in 1908, but several churches preceded it on the same plot of land.
The churches on the site have been known by various names, which are listed on the page about the church. Click on the MSBA Church tab to go to that page. The present church, now known as Mary S. Brown Memorial-Ames United Methodist Church, was originally named Mary S. Brown Memorial Chapel.
The purpose of this website is to disseminate information about the cemetery and church, collect additional information, enable correspondence among interested people, and work toward preserving the site for the future.
So what makes this site so important? The short answer is that the cemetery and church, taken together, form a strand of Pittsburgh's history extending from the area's earliest days to the present and relating to every part of it. The cemetery and church have ties to Native American prehistory, the settlement of the area by colonists from Europe, the first wars fought by the new United States, the Civil War, industrialization, urbanization and, since the church is still a living ministry, events spanning the 20th century. We're now into our third century at the same location!
Today the cemetery and church site now faces the dilemma of being a priceless treasure in need of restoration and conservation.


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Ex-Anglo official jailed for conspiring to conceal bank accounts
An ex-Anglo Irish Bank official jailed for conspiring to conceal bank accounts from the Revenue Commissioners must wait to hear whether he will be admitted to bail pending his appeal in January.
Bernard Daly (67), of Collins Avenue West, Whitehall, Dublin, had pleaded not guilty at Dublin Circuit Criminal Court to furnishing false information and conspiring to defraud the Revenue Commissioners as well as conspiring to delete accounts from the bank's internal system.
He was found guilty by a jury and sentenced to two years imprisonment by Judge Patrick McCartan on July 31 last.
Lawyers for Daly, who was the bank's former company secretary, told the Court of Appeal last month that his trial was unfair from beginning to end.
Although his bail application was unsuccessful, the court did not rule out hearing a renewed application for bail when the transcript of the trial became available.
His lawyers returned to the Court of Appeal this morning, claiming their position had been "fortified" by the transcript.
Seán Guerin SC, for Daly, said the prosecution case against Daly rested "almost entirely" on the bank's former head of compliance – a Mr Gillespie - who, the prosecution accepted, could have been seen as an accomplice.
Mr Guerin said the trial judge agreed to give an accomplice warning to the jury in respect of Mr Gillespie's evidence but the warning was "meaningless".
The trial judge told the jury that they must act cautiously on the evidence of Mr Gillespie. However, a proper accomplice warning required the judge to mention the "dangers of convicting on the evidence of an accomplice in the absence of corroboration".
The word 'danger' was simply not used, Mr Guerin said.
'Caution' lacked the force or urgency to bring home to the jury what the warning was actually for.
Furthermore, nothing was said about corroboration, Mr Guerin stated. The judge simply didn't tell the jury what corroboration was and what evidence was capable of amounting to corroboration.
These components of a corroboration warning were required by law, Mr Guerin said.
The trial judge did not address Daly's defence and that was what he should have done, counsel said.
Having complained about the warning, Mr Guerin said the prosecution advanced unstateable propositions of law and now had nothing to say about the contents of the warning.
Mr Guerin said the transcript was "embarrassing" to the prosecution because they had made submissions about the judge's warning which were "wholly unstateable".
The prosecution were now using liberal sprinklings of extracts from the transcript to persuade the court to wait until the full appeal yet they hadn't made any submissions that a proper accomplice warning was given, Mr Guerin said.
Counsel for the Director of Public Prosecutions, Dominic McGinn SC, said this was a matter which could only be determined at the full appeal hearing.
Analysing parts of the transcript was no substitute to analysing the case in the round, Mr McGinn said, particularly in relation to Mr Gillespie and the "artificiality of portraying" him as an accomplice.
When Mr Gillespie was approached firstly by Daly and then by O'Mahoney to omit information, he declined to do so, Mr McGinn said.
That was consistent behaviour by Mr Gillespie and Daly's lawyers were attempting to whitewash that now.
Mr McGinn said the case against Daly absolutely did not depend entirely on Mr Gillespie. The conspiracy could not have succeeded without Daly's cooperation and support, he said.
If there was some conspiracy afoot to stop the Revenue getting the information, Daly had to be involved, Mr McGinn said.
He said it was impossible to determine whether Daly had a strong chance of succeeding in his appeal without considering the entire transcript and all the circumstances of the case and he asked the court to refuse bail.
Mr Justice George Birmingham, who sat with Mr Justice Garrett Sheehan and Mr Justice Alan Mahon, said the court would wished to take time on its decision and would deliver it next week.
Daly's co-accused, Tiarnan O'Mahoney (56), of Glen Pines, Enniskerry, Co. Wicklow, was also due to apply for bail along with Daly pending his appeal but had adjourned his bid until the transcripts became available. He did not seek bail today.
Aoife Maguire (62), of Rothe Abbey, South Circular Road, Kilmainham, Dublin, has not sought bail but was given a priority hearing date of December 23 next for her appeal against sentence.
Maguire, a former assistant manager in the bank, had denied conspiring to delete bank accounts connected to Mr Seán Fitzpatrick from the bank's internal system and conspiring to defraud the Revenue Commissioners on dates in 2003 and 2004.
O'Mahoney, the bank's former Chief Operations Officer, had denied knowingly furnishing false information to the Revenue, conspiring to have accounts deleted from the bank's internal system and conspiring to defraud the Revenue.


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Gonneville-sur-Mer Vacation Packages
Gonneville-sur-Mer is a great place to base yourself while you are exploring Calvados as many of the city's most popular attractions are close. Two destinations that should be at the top of every visitor's itinerary is the fabulous Houlgate Golf Course and the much-loved Houlgate Beach. Two other great attractions that are close by Gonneville-sur-Mer are Villers-sur-Mer Beach and the Casino Gardens.
If you love nature and wildlife, head to the nearby parks and reserves. These are great places to breathe deeply and relax. Inhale the salty air, chat with the fishermen and make the most of the sunshine at nearby Cabourg Beach in Cabourg.
To play golf in a new setting, head for the greens at the Cabourg Public Golf in Cabourg.
Finding somewhere comfortable to base yourself close to the Gonneville-sur-Mer area is a breeze. The Le Grand Hotel Cabourg - MGallery Collection, the Mercure Cabourg Hippodrome and the La Closerie Cabourg are just some of the best places to find a warm welcome and a good night's rest.


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Encounternet - Home Page
The next step in wireless sensing and radio telemetry
Encounternet - Home Page
Encounternet System Overview
Encounternet Products
Using Encounternet to Study Social Networks
About us
Encounternet Products
Each Encounternet system that we build is unique and is tailored to the customer's particular needs. There are several existing options for tags and base stations, but if nothing fits your requirements then we can work with you to design a custom solution.
Due to the custom nature of each system build, we do not stock assembled hardware. Our current procedure is as follows:
: we will work with you to determine first, whether Encounternet is a good fit to your needs, and second, what sort of system you will need (tag specs, number and type of base stations needed, etc). At the end of this process we will have a detailed specification of your system, and can send you a price quote and construction timeline.
: system construction has two phases: fabrication, where we contract with a circuit manufacturing company to fabricate the tag and base station circuit boards, and assembly, where we assemble and test the tags and base stations. We do not carry board inventory and so require that at least 50% of the system cost be paid up-front to cover initial construction costs.
Shipping and support
: we will ship the system to you and provide support for your deployment. In some cases, particularly for large and complex systems, one of us can travel to your location or field site (at your expense) and provide training and assistance.
For further inquiries, and to start the consultation process, please contact
John Burt
System components
The core of every Encounternet tag is a circuit board containing a MSP430 microprocessor, a CC1101 433 MHz transceiver chip, and a nonvolatile memory chip. Tags have expansion port pins at their edges, allowing them to interface with sensors and digital devices. Depending on the battery used, tags may include an additional power conditioning circuit board. Most tags are embedded in epoxy and cast in a mold.
There are several tag styles that have been developed, from a 0.7g small bird tag to much larger tags for marine mammals. During the initial consultation, we will determine which type of tag design will be best for you.
Base Stations
Base stations currently come in two varieties, both of which are waterproof and ruggedized for harsh conditions. Since log data is downloaded wirelessly, base stations can be left unattended for long periods
The alkaline battery model is powered by two D-cell batteries and is housed in a Pelican case for easy battery access.
The solar powered model runs on a 2000 mAh lithium polymer battery charged by a solar panel on the top of the enclosure. This model is screwed shut, with a waterproof O-ring seal.
Master Node
The master node device is a modified base station mounted onto a yagi directional antenna, with a PVC tube handle. The master node connects to a PC computer with a serial-USB converter cable. The device is waterproof and rugged.
Software and Firmware
The system is shipped with a PC program called Pymaster, which interfaces with the master node. Using Pymaster, you can download logs from tags and base stations, set device parameters (such as tag clock, pulse rate, etc), track tagged animals, upload firmware to devices, and perform many other maintenance tasks.
All devices are shipped with the latest version of firmware and can run "out of the box". However, in some instances, you may need custom firmware. We can provide software development services to meet your customization needs.
Training, Consulting, and Support
We can provide training and system support, either remotely or on-site.


text: Zinwave DAS integrates WiFi3 technology from Edgewater Wireless 12 May 2015 04:09 PM Zinwave customers will now benefit from high density, multi-channel in-building Wi-Fi solutions integrated with their distributed antenna system solutionDAS provider Zinwave has formed a strategic alliance with Edgewater Wireless, developers of patented WiFi3 technology. Zinwave will be integrating WiFi3 into its proven DAS (distributed antenna systems) offering to provide the industry's first dedicated high density, multi-channel wireless and Wi-Fi coverage solution.Zinwave's new range of wireless products (launched at Mobile World Congress 2015) will now include Edgewater Wireless' WiFi3 technology and will extend the Zinwave's proprietary DAS solutions into a turnkey 360-degree solution for in-building wireless and Wi-Fi networks.UNIaccess productZinwave's Wi-Fi-enhanced product, branded as UNIaccess, is specifically designed to address high-density network requirements. Stadiums, arenas, hotels and casinos, convention centres, corporate and college campuses, shopping malls and high pedestrian traffic urban areas will benefit from WiFi3 technology."We're excited to form this alliance with Zinwave. They recognised the inherent value of Edgewater's patented WiFi3 technology for high-density Wi-Fi applications," said Andrew Skafel, CEO of Edgewater Wireless. "This strategic alliance with Zinwave represents a major step in the OEM/Licensing pillar of our three-part market expansion strategy highlighted at our recent AGM."This alliance, coupled with our early success on the patent licensing front and our current engagement with a Fortune 500 retailer, has created immediate opportunities for sales and company growth on all fronts."As a strategic partner, Zinwave will market and sell WiFi3 powered products for DAS applications. The new series of UNIaccess products will include Edgewater Wireless' patented high capacity WiFi3 technology, within its unique wideband active DAS solution."We've solved the biggest challenge for high density networks – CAPACITY," said Ian Sugarbroad, CEO of Zinwave. "Including Edgewater's high density WiFi3 technology as part of our integrated unified communications solution answers this challenge. We already have a huge CAPEX advantage with our UNItivity solution and with the addition of WiFi3, we now have an even better technology advantage for network operators with high capacity network requirements."Zinwave's wideband in-building wireless and IP coverage system, UNItivity, supports any combination of services between 150MHz-2700MHz on a single hardware layer, regardless of protocol or modulation scheme. It is also the only system to support multiple FDD and TDD LTE services simultaneously across any spectrum allocated globally. James Atkinson EditorLinkedIn |Google + |Email Leave a CommentPlease write code to prove you're humanMore on... Wave 2Ruckus Wireless expands 802.11ac Wave 2 Wi-Fi portfolio Xirrus unveils four-radio Wi-Fi solution for high density environmentsLANCOM Systems unveils long range 802.11ac access pointMore on... Critical CommunicationsFinland and Norway sign cross-border TETRA communication dealCC Europe 2017: Hytera showcasing new base station and handheld radioLatest in Wi-FiXirrus Wi-Fi deployed in London's St Pancras StationQualcomm unveils next gen 802.11ax Wi-Fi portfolioRuckus and Wifirst to provide Wi-Fi solution to hotels and campsites


text:
BP has made a significant oil discovery at its Gila prospect, which it co-owns with ConocoPhillips, in the deepwater US Gulf of Mexico. This is BP's third discovery in recent years in the emerging Paleogene trend in the Gulf of Mexico and reflects the company's ongoing commitment to the US offshore region.
BP has previously announced two other Paleogene discoveries in the Gulf of Mexico – Kaskida in 2006 and Tiber in 2009.
The Gila discovery was made by an exploration well on Keathley Canyon Block 93, about 300 miles southwest of New Orleans, in approximately 4,900 feet of water.
The well, which penetrated multiple Paleogene-aged reservoir sands, was drilled to a total depth of 29,221 feet. Appraisal drilling, including completion of drilling through the Paleocene section, will be required to determine the size and potential commerciality of the discovery.
"The Gila discovery is a further sign that momentum is returning to BP's drilling operations and well execution in the Gulf of Mexico," said Richard Morrison, Regional President of BP's Gulf of Mexico business.
Mike Daly, BP's Global Head of Exploration, said: "Gila continues our successful drill out of the prolific Paleogene play system in the deepwater Gulf of Mexico. Subject to successful appraisal, Gila, Tiber and Kaskida together offer the potential for significant future oil developments in the Keathley Canyon area."
BP owns a majority interest in the Gila discovery which is located approximately 25 miles west of Tiber, also located in the Keathley Canyon area. The lease for Keathley Canyon Block 93 was acquired in the Western Gulf of Mexico Lease OCS Sale 187 in 2003.
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Nautilus Build Guide by shadowbloodedge
Cover All Bases Jungle Build
Nautilus Build
First Recall
AP Tank Mix
Tank Come and Get Me Build
Siege Master
Ability Sequence
Not Updated For Current Season
The masteries shown here are not yet updated for the current season, the guide author needs to set up the new masteries. As such, they will be different than the masteries you see in-game.
Threats to Nautilus with this build
|Your ult goes wherever your target goes. This makes Kha'zix the easiest to handle because he cant get away even if he jumps
|Relatively weak and easy to counter
|Apparently a thing now (to each their own I suppose). He might have burst but once hes locked down hes toast.
Hello there, Shadowbloodedge here writing my first guide. I'm here to discuss a build I have created for Nautilus, The Titan of the Depths. In this guide I will discuss how to effectively jungle and scare the life out of your targets.
Nautilus is a man trapped in a diving suit because of an incident at sea involving The Harrowing. Though he may look like one of leagues more evil champions, he is not. He is simply looking for answers and his family. Hes a stranger in the world and joined the league in hopes of not only finding out his past, but the crew of sailors that let him drown in the sea that day.
Jungling with Nautilus
Weighing Your Choices
- Really Tanky
- Nothing but CC Control
- Every form of CC in the game (Stuns, Slows, AoE, DoT, Hook, and Knock-ups)
- Naturally terrifying presence
- High mobility due to Dredge Line
- Exceptional Ganker
- Great Initiator
You can use Dredge Line to monkey your way through the jungle and avoid enemy champions like no other, plus the cooldown is reduced by half if it hits terrain. Nautilus' shield Titan's Wrath also provides excellent defense early game and perfect cover for tower diving. His ult Depth Charge is ideal for striking entire teams or chasing down near death champs.
- Slow as all get out
- Abilities are fairly weak without AP
- EXTREMELY Mana hungry
- Low Magic Resist early game
- Difficult to invade enemy camps with early
- Expensive
Nautilus is among the slowest champions in game and this can be a problem through out the game. Getting boots early is an ideal way to pass this. Nautilus also uses AP for his abilities and not building AP until late can be difficult but its well worth the pay off. His build can prove to be expensive at times.
12/0/18 is how i play jungle Naut. Runic Armor is a must have because of the insane amount of damage you can absorb with Titans Wrath plus it keeps it up longer meaning increased AoE. Strength of the Ages works well with cinderhulks bonus health ability plus scaling your shield strength. Oppressor procs on every single one of your abilities.
Although Nautilus is classified as a tank he doesn't particularly scale well with Armor, I'm guessing because of his tremendous amount of CC they needed to make drawbacks. To negate this I use flat armor seals, marks, and quints. Combined with Unyielding as well as just normal scale and you start with 50+ Armor. Now I didn't forget MR. Take scaling MR Gylphs to ramp it up late game.
Generally there are only 2 other spells I take with this build, Smite being the gold standard must have.
Flash is optional for popping out of combat and getting away fast
Ghost is perfect because of the speed buff and ability to move through units
The Jungle Route
Nautilus Jungle route is fairly easy. First, take Titan's Wrath and go for your teams Blue after that, take Riptide and wander down to take Wolves and then Raptors. Take the Red buff after this. Take Dredge line at level 3 and check in on Top and Bottom lane. If they need a gank go for it if youve got good synergy and communication with the laners, if they are fine work your way through the jungle and clear out as many camps as you can. Once you hit level 6 recall, buy your jungling item and continue to wander the rift jungles.
Also you will want to take Blue as many times as you can because of how mana hungry you are. But, depending on when or what mana item you buy, you will want to start handing it off to the mid or other lanes.
As always,Take Dragon as much as much as you can
Rift Herald is very helpful when besieging towers as well as scaling your abilities.
Tank AP Mix
The first thing you should always take is Hunters Talisman, a few health potions, and a trinket. Talisman is ideal for your heavy mana kit. Once you get around 1200 to 1600 gold (depending how long you stay in jungle and how well you are doing) Recall and we can begin building.
When I build Nautilus, I always build Stalkers Blade. As for enchantments I suggest Cinderhulk above all else. The super health buff just makes your shield AoE that much stronger. Combine that with the burn DoT and your W becomes super powerful in early game which leads to fast camp clearing and strong tanks. When buying this, also buy a pair of Boots of Speed to hold you over for awhile in terms of movement
An item that is a necessity with Nautilus is Rod of Ages. Massive health buff and keeps your mana up. Plus Ability Power that scales with all of your abilities for extra ganking power. Randuin's Omen is a perfect choice for the 4TH or 5th slot. The armor, the health, and the ridiculous AoE slow is perfect for Nautilus.
After all that armor and health we build Mercury's Treads. With juggernaut being gone now, the new enchantment doesn't give tenacity anymore which was fairly useful for Nautilus. The magic resist helps too. Take with either Furor, Homeguard, or Alacrity.
Finally we top all this off with Warmog's Armor. All this time we've been building health on top of Cinderhulk and because of its new passive (bonus health) we've been stacking a ton of extra health. Getting Warmog's will easily give you between 3500 and 5000 health if you built the previous items.
Tank Come and Get Me
Another build you could use is more of a supportive jungle. First build Trackers Knife with Cinderhulkand dont forget to swap over to a sweeping lens.
From here build the bread and butter of this build: Thornmail. With Thornmail, you can reflect damage based on your armor but as Nautilus you can actually mitigate the damage you'll receive and send it back at them with one push of the W. Your Shield AoE plus Cinderhulk and Thornmail will prove to be a menace seeing as you can keep them in fighting range using your CC moves.
From here id recommend Spirit Visage and Randuins Omen Spirit Viasge will grant you cooldown and much needed health for Cinderhulk and your shield. Randuins will just make you that much more of a CC menace. Finish this build with Ionian Boots of Lucidity and Banshees Veil because what could be better than cooldown and TWO shields.
Siege Commander
This build is just plain fun. Who doesn't wanna just ram down towers like they were rag weeds. This build is totally situation based. First build your jungle item Stalkers Blade or Trackers Knife with Cinderhulk. Personally id go with Trackers so you can see incoming threats to your tower tanking.
Id go into Iceborn Gauntlet and Zz'rot Portal right after. You get a burst of armor, MR, and Cooldown. Gauntlets icezone works very well to stave off incoming enemy minions. Zz'rot is good for light tanking and of course turret damage Go into Banner of Command and Merc Treads WITH CAPTAIN ASAP. Not only do you get more AP, Health, and MR you are helping your team in teamfights. Shield the biggest minions to break through turrets in no time. Finish off with Spirit Visage for that extra cooldown and shield boost.
Other Items
These items are also useful on Nautilus
Frozen Heart adds a massive amount of armor and mana giving Nautilus the ability to stay in combat longer and deal more damage while slowing down enemy attack speed. Id recommend this as an alternative to Randuin's Omen if needed.
Rylai's Crystal Scepter is an adequate replacement for Warmogs. it may only give you half the health but it will give you more slowing power plus an AP boost.
Abyssal Scepter eats MR for breakfast plus adds AP.
Iceborn Gauntlet gives you tons of Armor, Cooldown, and and that frozone. You cant go wrong with it.
Take Righteous Glory for more support based jungling or besieging towers. The movement speed buff is fantastic plus it mitigates the mana hunger
Locket of the Iron Solari is also a more support oriented item but perfect for team fighting
Team Work
Nautilus works very well in team fights and groupings. He can support AD Carries quite well but Nautilus' team work potential lies with Dredge Line and Depth Charge to reel enemies in, and hunt those trying to run. Nautilus works exceptionally well with Thresh and Blitzcrankbecause of their pulls and stuns.
When ganking any lane its important you Land your anchor hooks. This is the key difference in a failed gank or not.
Also when decided to play a Naut jungle check your team compostion. Do you have enough tank? Need more tank? (Always) Look at specific champions to work with too. For example, Graves can slide in and blow them up if you land a hook, stun, and Riptide on them. Look for champions that can work well with your CC
Champions I'd recommend pair with:
Ashe: With all her moves slowing and applying Frost Shot it will be easy to gank her lane
Zed: Ganking a mid Zed and helping them get in and out benefits all
Volibear: Dredge when he charges in, you anchor out to bring them into his charge and behind him. CC them to death with a polar bear.
Thresh: Hooks
Blitzcrank: See Thresh
Graves: High Mobility and burst damage paired with a good dredge can turn a lane around
Jhin: The CC possibilities are endless. Keeping an enemy champion in line with Jhins ult spells disaster for them
Xin Zhao: Pair your R with his Q and prepare for the double knock up CC fest
Tahm Kench: 1. Ult in with him. 2. Combine Q's 3. CC heaven.
Alistar: Alistar is common siege comp champion. Combine any of your CCs for maximum effectiveness.
Kalista: Using Kalistas ult on Naut is a glorious thing. It is risky to ult someone not your support but if played right, Kalista will be throwing absolute hell at the enemy. Come out of her ult blasting.
Leona: The burst and combinations of stuns and roots you can do with these two is amazing.
Taric: Just Tarics presence is enough to enjoy. Having your already ridiculous armor boosted is fantastic
Yasuo: 2 for 1 ult sale. Engage with yours and have Yasuo follow suit.
Lulu: Hugifiy!
Annivia: Dredge line her walls for escapes or CC trapped enemies behind those walls
Orianna: More shielding and CC. Your ult combined with hers guarantees the enemy is reeled in
Malphite: Pop your ult and as soon as they come down, send in the mountain.
Jinx: Using her traps to turn a fight around is a wonderful thing. One they are trapped, CC them as hard as you can to turn the tide of the lane.
*Remember these are from my experiences
Supporting with Nautilus
Nauts got the CC and the lane presence to be the perfect candidate for tank supporting. Building him with strong DPS or utility can make all the difference in a bot lane firefight. In this section i will be explaing how to support and be effective as Naut.
The Difference Between Us and Them
Tons of CC
Dominant presence in lane, very intimating to others
Fantastic bullet Sponge
Great team synergy late game
Engage ability is skill shot reliant
Mana Hungry
Nautilus is one of the those supports that just covers all the angles. You can make him DPS or Siege Master or whatever you need in game. His chain CC combos absolutely destroy lane and strike uncertainty and fear into the enemy. Just his presence can make a difference. I dont know how many times I just stood in lane and neither the ADC or Support would come close to me. This is good, it will allow your ADC to farm and get ready to deal tons of damage.
But there are draw backs. Nautilus is still a very slow champion and if you use Dredge Line to get back into lane you have to sit through the cooldown, in which case an opening may occur for the perfect kill but you cant make it. Mana is also a heavy issue. Use too much CC and you'll have none when it matters. Nautilus doesn't scale Armor or MR like most other tanks do so in early waves and levels he himself is actually kinda squishy.
Bond of Stone is essential for this. Using your shield you can mitigate damage you would take when your ADC is attacked so everyone's gonna hurt less.
Naut as a support will rely significantly more on mana. Take Seals of Mana Regen, Marks of Armor, Glyphs of Scaling Magic Resist, and Quints of Mana Regen. These runes should allow you to adequately stay in lane while still being able to dish out CC.
For a supportive role its always advised to take Exhaustbut there are other options you can take. Heal is a good call if the ADC decides to go Flash/Barrier
Gear Up
As versatile as Naut is hes still gonna need the right gear. Items that compliment the ADC are fine and dandy but you still want to look out for yourself as well
The Starting Item Situation: Gold vs Wards
As you see above, I have Sightstone in the first couple of items but its gone into the core build. It reappears as Ruby Sightstone or Eye of Equinox in the optional item slots. The reason behind this is sometimes, depending on the way the game goes, vision isn't needed.I have seen games that once the lanes are pushed and laners are all over the place, wards are used alot less. Also i have seen games where wards are constantly needed. Like I said its all situational. But note this: You ALWAYS buy a sightstone early game as a support. You will absolutely need it early game to prevent ganking and keep an eye on your valuable camps. And dont be afriad to buy Pink Wards. A well placed pink ward can last the whole game and give great map awareness.
That being said, it brings me to my next part: Face of the Mountain or Eye of the Equinox
Face of the Mountain
Personally Face of the Mountain is my go to for Naut. What sets it apart from Eye of the Equinox for me is the desperately needed cooldown reduction and the most important component of all: Allied Shielding. The shield protects them based on 10% of your max health and trust me you will have a ton of health. As Naut, you can activate this on an ally, pop your own shield, and get out of a team fight rather safe. Face of the Mountain also lets you heal your ally up to for times by killing weak minions instantly and sharing the gold with them But taking this means you'll have to give up a slot for warding, and if warding becomes central to the whole game you'll be missing a slot.
Eye of the Equinox
Its a good call but not a favorite of mine. Sure you get the healing factor for your ally and a ton of vision control which lets you take up another item and you still get gold income. Its a good item, it does give more health than Face of the Mountain but not by much. The draw back here is the cooldown reduction and the shielding is gone. There have been many a game where that shield has saved my ADCs and that cooldown helped me dredge my enemy to death.
Standard Tank Build No Gimmicks
Once youve got your first pick sorted out its time to move on to more items. When I like to just keep things simple you cant go wrong with Frozen Heart, Locket of the Iron Solari, and Merc Treads with Captain. Frozen Heart will solidify your cooldown and give you a good mana pool to draw from as well as slowing of enemies. Locket will give your team MR and a shield (or another based on first item). Merc Treads will keep you out of their CC and bring them into yours. Finish up this build with Spirit Visage and a Warmogs to top off your cooldowns, keep you safe from sneaky mages, and bolster your healing tremendously as well as your W strength.
Power House
Going with the first item, you might see your lane needs to be more aggressive. Try Iceborn Gauntlet paired with Randuin's Omen and an Abyssal Scepter. Iceborn gives you much need armor, cooldown, and mana but also the spell blade effect. This can potentially triple your basic attacks damage when used in tandem with your passive. Randuins, much like the ice field created from Iceborn, will slow down enemies and allow your CC to take full advantage of them. Abyssal Scepter will not only boost your damage output to eat their MR making you hit harder and giving your ADC less work to do to bring the kill in. Id finish the build with Banshees Veil for the free hit and Boots of Swiftness to put Randiuns and Iceborn to work alot faster.
Building DPS with Nautilus is a fun way to ruin someones day. After your first item go straight into Sunfire Cape and Randiun's Omen. First of all, their ADC wont dent you after that much armor. Second, they are gonna take so much AoE DPS thanks to Randuins slow and your W combined with Immolate. Build a Righteous Glory to help your team catch up to runners and keep yourself in DPS distance. Round out this build with some MR. Spirit Visage and Merc treads do the job just fine.
Return of the Siege Master
Besieging towers and lanes with Naut is just plain fun, and with this build not only will you rip towers apart you will effectively help your teammates. After the first item go into Iceborn Gauntlet to power up your basic attacks and boost your mana. When attacking towers after using an ability, the ice field will proc on towers, damaging or killing nearby enemy minions making it easier to attack the tower with a full minion wave at your back. The next to items should be Zz'rot Portal and Banner of Command. Zz'rot will give you a much needed MR and Armor boost while allowing you to attack towers you might not even be close to. Banner of Command will boost your damage output as well as give your team and AoE MR Buff but the best part is ramping up your canon minions to blast down towers. Finish off with Righteous Glory and Merc Treads. Glory will get you and your team up to that tower and help bring it down.
Situation Based Items
Zekes Herald is a good way to have synergy with the ADC as well as giving them crit and attack speed. The AP and Armor are also nice buffs.
Thornmail is best used against on hit ADCS such as Vayne or Lucian.
Rylai's Crystal Scepter is a good option because of the AP buff and even more CC stopping power.
Here are some of the ADCs ive supported and worked with the best over the past year:
Tristana: With her tower damaging explosives, playing as a siege support is ideal.
Vayne: When Vayne bolts an enemy to the wall, this gives you the perfect opportunity to waltz up and hit them with your passive, thus saving your Dredge Line if they decide to flash away. Also, where Vayne does percent health damage, taking on rival tanks are easier.
Kalista: Ulting you into a crowd and having you go ballistic on them is not only fun but highly effective plus with the bond you and her will share through her abilities, she can do bonus damage to the target you most recently attacked based on your health.
Miss Fortune: Rooting enemies in place and keeping them in her ult is the best way to work with Miss Fortune
Caitlyn: Her traps combined with your CC will bring in the kills
Jinx: See Caitlyn
Graves: Given Graves new need to reload every 2 shots(Which, by the way, makes no sense because he has a DRUM on his shotgun) your CC will keep enemy champions in place while he painstaking reloads to finish them off.
About the Author
My league login name is Shadowbloodedge, but on the actual game its 2000 Angry Jews.
I picked up playing Nautilus when I first got into league because I thought he was just plain cool lookin. At first, I hated him. I thought he was horrible. I decided to try him again and fell in love with his playstyle and ability to control a game no matter where he is played.
Hopefully we see each other on the rift someday. I just hope your not on the wrong side of my anchor.


text:
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