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Nov 18, 2014
Lazy day outfit
5 comments:
Love it ❤ReplyDelete
So laid back and casual yet chic!!
You carry those slouchy pants soo effortlessly everytime. ❤
- Anonymous11/18/2014 3:21 PM
The whole look is amazing! I hate Monday morning and it's so hard to select what to wear on a Monday morning when we are in complete zombie mood! This is totally what I would opt as it is stylish yet laid back ^_^ totally cute :*ReplyDelete
You're so naturally pretty! Love the whole look ❤ReplyDelete
You're the bestest blogger ever and my personal favorite too :')
Cheers :*
- Anonymous11/24/2014 11:24 AM
Hi aashna I am a big fan of yours. I just love your styling and the way u carry it. I regularly see your blog. I follow you in insta too! :)ReplyDelete
Well your 17 yrs old fan needs your help.
Please help me
I ve participated in lakme salon's competition.
And we have got 3 looks gamthi., traditional and western. Now i really need your help.. Please help me out with costumes. I am from gujarat. And m going Mumbai after 2 days so please suggest me some shop. The competition is really very tuff. I thought of wearing a gown so please can u suggest me some good shop to buy something extra ordinary
I really need ur help. Please rply asap

subset: commoncrawl


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How can I find out the demand for rental properties in an area?
Asked on Dec 15 2010, General in Manchester | Report content
Answers (1)
Check Zoopla or Rightmove to see how much stuff is on offer, and the spread of prices. Then go back once a month to see if they've gone. But the short answer is that in M21 rental demand is high. Get the spread, like I say, and price yours according to a. how fast you need to find a tenant and b. how long the lease is.Answered on Jan 6 2011, Report content
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Train pendolino ETR 480 HDGHL1031 HDGHL1031 Trains
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1 motorized driving trailer
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1 transformer
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Colombia's Uribe Said To Hinder Militia Probes
Friday, October 17, 2008
BOGOTA, Colombia, Oct. 16 -- Far from pressing to uncover the truth, President Álvaro Uribe's U.S.-backed government has hindered investigations into links between paramilitary groups and the country's political establishment, a leading human rights group said in a report released Thursday.
Human Rights Watch, which has documented ties between Colombia's army and paramilitary death squads since the 1980s, said in a 140-page report that officials have made important strides in investigating the illegal, anti-guerrilla paramilitary groups that terrorized this country until they were demobilized in 2006.
But the report accused Uribe of trying to obstruct the probes, instead of supporting them as he claims in his frequent trips to Washington. It also highlighted how Uribe and his aides have tried to tarnish the Supreme Court, which is carrying out an assertive probe that has already found ties between dozens of members of Congress and paramilitary groups.
"President Uribe's and his cabinet members' repeated verbal attacks, bizarre public accusations and personal phone calls to members of the court create an environment of intimidation," the report said.
"The Uribe administration has often spoken about the importance of the truth," it added. "However, at the same time, it has repeatedly taken steps that risk undermining the investigations."
In a statement, the Colombian government called the report simplistic and mistaken. It said the Uribe administration has done more than any other to dismantle a vast paramilitary network known for carrying out massacres and trafficking cocaine. The statement said the government has strengthened the attorney general's office and respected the independence of institutions.
"Colombians want to completely clear up the circumstances of the violence carried out against institutions and the people by all the armed groups," the statement said. "To assert that this is not in the government's interest is ridiculous."
The report comes at a delicate time for Colombia, which has been aggressively lobbying for the U.S. Congress to approve a free-trade agreement.
During the U.S. presidential debate Wednesday, Republican John McCain said approval of the pact was a "no-brainer," benefiting American exporters and solidifying American support for Washington's closest ally in Latin America. Democrat Barack Obama, however, said he opposed the agreement because of the killings of Colombian labor leaders and a lack of prosecutions in the cases.
The rights report, titled "Breaking the Grip? Obstacles to Justice for Paramilitary Mafias in Colombia," noted that the Uribe administration had shelved a proposal that would have allowed tainted politicians to avoid prison after it became clear the plan would hamper efforts to win the trade pact.
Still, Human Rights Watch said Uribe's government blocked legislation that would have reformed Colombia's Congress to reduce the influence of paramilitary commanders. That move has allowed lawmakers who are under investigation to be replaced by allies from their own tarnished parties.
The government also tried to push constitutional amendments that would have stripped the Supreme Court of the jurisdiction to investigate lawmakers implicated as having paramilitary ties. That proposal was tabled Tuesday.
Human Rights Watch said that in some cases, investigations into ties between paramilitary units and high-ranking military officers have stalled. The report noted that retired Adm. Rodrigo Quiñónez remains free, even though former officers and a top paramilitary commander have alleged that he had close links with death squads.
More recently, the report said, the government strongly supported Gen. Mario Montoya, the commander of the army, despite allegations that he smuggled arms to paramilitary groups earlier this decade. Montoya has denied allegations made by a former paramilitary fighter to prosecutors, and Uribe has called the general an "honest soldier of the nation."


text:
COLUMBUS -- State lawmakers are moving forward with a revamped unemployment compensation reform package aimed at ensuring sufficient funds are available to pay benefits to out-of-work residents during times of economic downturn.
Current subscribers have full access to all online news content as part of their subscription. If you are a current subscriber, please log in with your website account information for full access. If you are a current subscriber, but have not yet registered for access to the website, please call our Circulation Department at (330) 287-1615


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GLACE BAY — A Glace Bay woman fights back tears while sitting outside a tent she says her family has been living in since being evicted from their apartment over sewer issues.
"I borrowed a tent — had no choice, we had nowhere to go," said Kathy (Trout) MacNeil.
MacNeil said she is married but sometimes goes by her maiden name Trout.
MacNeil said there were five floods in the apartment in June as a result of sewer backups and it ruined their belongings and made the living conditions unhealthy for her family, including husband Dave MacNeil and children Jessica, 11, and Jamie, 13.
"My daughter lost everything — has nothing — is so distraught over all of this. She lost all her clothes and has to wear mine, 10 times too big for her."
MacNeil said that on June 18 at 10 p.m. Kevin Pembroke, owner of Pembroke Properties, came to check out the sewer issues and told the family they had to leave.
"He was trying to kick us out into the middle of the night, we had nowhere to go."
The family refused to leave but MacNeil said that on July 8 they were forcibly evicted through a Cape Breton Regional Municipality bylaw order.
She said that's when her family was forced to move into the tent. Their son is staying with a friend in Glace Bay.
"Our landlord is supposed to have it fixed within 30 days from July 8 but he hasn't been back yet."
MacNeil said they can't find another apartment and have been on the regional housing list for four years.
"Our rights have been violated here and no one cares, no one will help us."
She said neighbours are allowing them to come inside to bathe and to eat.
Rick Fraser, manager of CBRM building and bylaws, said the family was advised this week they can go back in the apartment.
"She has been advised she can move back into the building," he said.
He said the sewer line has been repaired.
"There is still some more work to be done by the landlord but nothing life threatening, so she can go back in."
Fraser said the issue with the apartment began when MacNeil called their department and lodged a complaint about unsanitary conditions due to a sewer backup.
Fraser said the inspector found there was sewer backup in the building.
"It had happened a number of times in the past and was corrected by the landlord, but there was still a problem as it happened recently again," he said.
"Based on the conditions he advised the individuals they had to relocate until that problem was corrected."
However MacNeil said she can't take her family back in there as the CBRM bylaw officer said air quality tests had to be taken, which hasn't been done yet.
"No one has been back to clean it, it's not healthy, I can't take my children back in there with it like that."
She said as well they've received an eviction notice through the tenancy board for July 31.
"We have appealed it. The hearing was Wednesday, but he (the landlord) didn't show up so it's been moved up two weeks.
"We're not only fighting for our rights but the rights of others going through the same thing out there."
Pembroke said that in 35 years he has never called the tenancy board on anyone and has never been served by the CBRM.
"I had to allow this to happen as these people are not reasonable to deal with. All they want to do is scream about their charter of rights."
Pembroke said he had plumbers and vacuum services in there and problems were found to be caused by items other than toilet paper being used in the toilets in this family's apartment.
"It caused overflowing and a ruptured sewer because they had it plugged."
He said the CBRM issued the order that the place wasn't livable because repairs were required after grey water went into the subfloor.
"I also was concerned because of a safety issue with the children. We're afraid of getting mould, mildew under the subfloor."
Pembroke said he hasn't been able to go in and fix anything, as belongings and the dog are still there.
He has an order from the tenancyboard where the family will be evicted from the property July 31.
Glace Bay MLA Geoff MacLellan said he and his staff have met with MacNeil several times and have been working hard to help them. MacLellan said he's been in contact with the Cape Breton Regional Housing Authority numerous times and has been told MacNeil is either first or second on the list for housing. He said staff has even searched for apartments for the family.
"We've also checked — not that this is a good option — with the shelters to see if there as anything they could do until regional housing came through."
"We've been as active as with any file. I don't want to see anyone living in a tent."
MacLellan said MacNeil is upset and frustrated and doesn't believe he is trying his best to help her.
"I'm doing my best exercising everything I have to help her out. We are confident this family is close to getting in a regional unit."
Living in a Tent
Kathy (Trout) MacNeil talks about what's it's like to move living in a tent.
• "It's cold and damp at night."
• "We get $480 for food from social services like everyone else, but living in a tent, without a stove or anything, we have to go out and buy our food. As a result, we ran out of money earlier. I haven't eaten in three days."
• "We are eating sandwiches we buy from the grocery store, chips and juice. "
• "We have four and a half garbage bags of clothes between all of us."
• "Our dog is allowed to stay in the house and we are allowed in twice a day only to feed him."


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Can The Founder Of Pandora Media, Inc. Save The Company?
- A low probability of achieving 2020 revenue targets through subscriber growth and new businesses ventures.
- Continuing annual losses due to required revenue sharing with record labels.
- A large cost to develop a competing streaming service in an already crowded market.
On March 28th, Pandora Media (NYSE:P) announced that Tim Westergren, a co-founder of the internet radio pioneer, will return to the company as CEO, replacing Brian McAndrews. In the past six months, investors have pushed Pandora's stock down 50% amidst fears of strong competition from Spotify and Apple Music. Unlike Westergren, who previously served as CEO between 2002 and 2004, McAndrews had no prior music experience having worked at the likes of Microsoft, General Mills, etc. Will Westergren's return to the helm reinvigorate and rescue the company?
Pandora stock price chart by amigobulls.com
2020 Revenue Targets
During the 2015 annual earnings release in February, Pandora's management stated the company has a 2020 revenue target of $4 Billion. How likely is Pandora to reach this target?
The majority of the company's current revenue is generated through subscription and advertising sales. In the most recent fiscal year, Pandora generated $1.1 billion; a $200 million or 26% increase from fiscal year 2014. Pandora's second revenue channel is newer and much smaller. In October 2015, when McAndrews was leading the company, Pandora acquired ticketing startup TicketFly for $450 million in cash and stock. Pandora is currently forecasting that TicketFly will generate $300 million in revenue in five years.
How likely is the company to meet these two revenue targets?
Assuming a continued compounded annual revenue growth rate of 26%, subscription and advertising sales would generate $3.7 billion by 2020. Possible, but not likely to happen.
Unlike print magazine subscriptions, consumers are unlikely to pay for multiple online music services. Why would an individual subscribe to Apple Music for on-demand music and Pandora for radio? The rapid ascent of Apple Music and Spotify reduces growth opportunities for Pandora. Apple Music launched in June 2015 and is already projected to generate $1.2 billion in 2016; more than Pandora generated in 2015 even though it launched a decade earlier. Can Pandora realistically achieve 26% annual compounded growth while competing with Spotify and Apple Music?
Investors would hope that TicketFly revenue can hit $300 million in five years, but that is also not likely to occur. In 2015, TicketFly generated $10 million in revenue. Growing to $300 million in five years would require a 97% annual compounded growth rate. For comparison, ticketing revenue for LiveNation in 2015, parent company of TicketMaster, was $1.7 billion with an annual growth rate of 10% versus 2014 (using constant currency). Assuming TicketMaster continues to grow at a 10% annual compounded rate, in five years Pandora is forecasting that TicketFly will own nearly 11% of the ticketing market (compared to TicketMaster) versus its current 0.5% market share. This growth target is extremely aggressive and unlikely to occur.
Future Profitability
Similar to many technology companies, profits have thus far alluded Pandora. Since going public in 2006, Pandora has lost money every fiscal year with 2015 having the highest annual loss yet.
As mentioned above, the majority of Pandora's revenue engine is derived from subscriptions and advertising. Unlike Spotify and Apple Music where listeners can pick the song to play, Pandora is a radio station and thus subject to pay a royalty rate for it's services. This rate is set by a tribunal of judges at the US Library of Congress. Spotify and Apple Music, which are not radio stations, are not subject to this law and negotiate their own rate with studios directly.
Based on a ruling in December 2015, the royalty rate that Pandora must pay will increase by 21% and will then adjust with inflation yearly until 2020. In 2015, this royalty cost consumed nearly 50% of Pandora's revenue. Even if Pandora is able to greatly increase its subscribers and listener hours, a large amount of the revenue will be paid for royalties. Pandora's largest business cannot achieve economies of scale. This will likely lead to continued annual losses.
Streaming Service Cost
As mentioned above, Pandora is not an on-demand service like Spotify and Apple Music but rather a radio station. In order to compete with these larger services, Pandora announced it will launch a Spotify-like clone in 2017. The company acquired key assets from Rdio for $75 million last year and will spend an additional $120 million on development. The combined cost for the Spotify clone, if on budget, will be nearly $200 million.
When Pandora's on demand product launches, it will be competing against incumbents Apple Music and Spotify. In addition to the high development cost (10% of the company's market capitalization), a large (i.e. expensive) marketing campaign will be required to lure in customers. Pandora's on demand service will likely lose money for the foreseeable future. Pandora's internet radio business launched over 10 years ago with no competition and still has not generated an annual profit. Pandora's on demand service will launch with entrenched incumbents. How long will it take for that service to be profitable?
The return of Tim Westergren as Pandora's CEO is undoubtedly a positive development for the company. Brian McAndrews stood by while Spotify and Apple Music stole the limelight, immensely overpaid for a company that generates minimal revenue (TicketFly) and was unable to earn a profit.
Investors should not expect that Westergren's return will be sufficient to save Pandora. The company's revenue targets (given by McAndrews) seem unrealistic, it's royalty costs will continue to siphon away nearly 50% of revenue and it's Spotify-like service will launch into a very crowded market. Absent an acquisition, Pandora is likely to continue to underperform.


text: School Home Page \ Historical List of Basketball Players Standings Through March 19, 2007 Big South Basketball W L HOME ROAD STRK CONF Winthrop University 29 5 14-0 High Point University 22 10 11-3 Liberty University 14 17 8-6 Coastal Carolina University 15 15 7-7 University of North Carolina at Asheville 12 19 6-8 Virginia Military Institute 14 19 5-9 Radford University 8 22 3-11 Charleston Southern University 8 22 2-12 Edit Standings Roster No. Name Pos Eligibility Ht Wt Birthplace 12 Terrell Brown G Senior 5-9 155 Charlotte, NC 23 Jason Cadena F-C Freshman 6-8 210 Lawrenceville, GA 33 Ferdiand Cain F-C Senior 6-8 210 Bloomfield, CT 15 Donnell Covington G Junior 6-2 165 Goose Creek, SC 10 Trent Drafts G-F Senior 6-8 185 Beaufort, SC 35 VJ Fails F Sophomore 6-7 230 Charlotte, NC 00 David Hampton C Sophomore 6-7 215 Orangeburg, SC 11 Thomas Harrison G Senior 6-1 180 New York, NY 22 Michael Himes F Sophomore 6-3 185 Kershaw, SC 23 Vernon Huger F Junior 6-8 215 Charleston, SC 1 Dwayne Jackson G Junior 6-4 185 Fort Meyers, FL 45 Isaac Jones C Junior 6-8 220 Roswell, GA 41 Giedrius Knysas F Freshman 6-9 205 Lithuania 2 Chris Moore G Sophomore 6-1 180 Morganton, NC 34 Carter Stiglbauer F-C Junior 6-9 220 Columbia, SC 5 Mario Williams G-F Senior 6-3 205 Augusta, GA 20 Byron Wimphrie G Freshman 6-1 170 Piedmont, SC Edit This Roster College Navigation Conferences College Basketball America East Atlantic 10 Atlantic Coast Atlantic Sun Big 12 Big East Big Sky Big South Big Ten Big West Colonial Athletic Conference USA Horizon League Ivy League MAAC Mid-Continent Mid-American MEAC Missouri Valley Mountain West Northeast Ohio Valley Patriot League Pac-10 SEC Southern Southland SWAC Sun Belt West Coast WAC Opinions News Scores/Schedule Standings Teams Players College Football Opinions News Scores/Schedule Standings Teams Players Quick Facts Athletics Logo Established: 1964 School Type: Private Baptist University President/Chancellor: Dr. Jairy Hunter Location: Charleston, South Carolina Campus Size: 300 acres Enrollment: 3,000 Faculty: Mascot: Bucky Stadiums: Buccaneer Field, CSU Field House Colors: Navy & Gold Team Nickname: Buccaneers Conference(s): Big South Conference Homepage: www.csuniv.edu Athletic Homepage: http://csusports.athleticsite.com/ Local Radio: Basketball Ranking: RPI Rating: Football Ranking: BCS Rating: Edit These Facts Retrieved from "http://armchairgm.wikia.com/wiki/Charleston_Southern_University_Basketball?oldid=33674" Ad blocker interference detected! Wikia is a free-to-use site that makes money from advertising. We have a modified experience for viewers using ad blockers Wikia is not accessible if you've made further modifications. Remove the custom ad blocker rule(s) and the page will load as expected.


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Sword Wave
CD: 10sec
Range: 20m, single target
Recover: 10 Yin upon hit.
Effect: Deal medium damage to far away target.
Shadow Drive – When Shadow Drive is used after Sword Wave, a shadow will be summoned and attack up to 6 times. If all the shadow hits land on the same target, the damage is reduced.
Burst Mode – After activating Burst Mode, many sword waves are launched at the target, dealing up to 3 times damage with the last hit knocking down the target; consumes 3 Yang.
A good starter skill. Sword Wave and Triple Slash chained to Shadow Drive are the two reliable means to accumulate Yang. Only the 1st hit of Sword Wave recovers Yin; the subsequent 6 hits from shadow don't recovery any Yin.
Blood Drain
Type: Blood Drain
CD: 10sec
Range: 16m
Recover: 10 Yin upon hit.
Effect: Charge towards your opponent and slash to deal medium damage. If your target has no Composure, induce Suppress effect. Can be used in air. If the target's HP is below 20%, deal critical damage. If the skill is used to kill an elite target, recover your own HP and refresh the skill's CD.
Shadow Drive – If Shadow Drive is chained after Blood Drain, deal additional 50% more damage and float your target.
Burst Mode – After activating Burst Mode, shadow attack will be added to the original cast animation of Blood Drain, follow by a knockdown effect; consume 1 Yang.
This is an approach skill to get close to your target who is far away. However, it is mostly reserved for last hit, to get the HP leeching effect.
Aerial Slash
CD: 15sec
Range: 10m
Recover: 10 Yin upon hit.
Effect: Can only be used on aerial targets to deal massive damage. Can be used again during its CD time, to summon a shadow and unleash a charged AOE attack with knockdown effect.
There are a few skill combos, which can put your target into the air, namely Triple Slash > Shadow Drive, Blood Drain > Shadow Drive or the knock up effect of Time Stop. The damage is very high but in boss battle, you hardly have the chance to launch the boss into the air because of the constant blocking when his Composure is non-zero.
Time Stop
Type: Escape skill
CD: 28sec
Effect: Blink backwards and leave behind a shadow which summons a force field to stop all the enemies within the AOE. After 4 sec, throw all the enemies into the air.
Every class has a skill which allows him/her to escape from paralyze/knockdown effect. ZhenWu's escape skill, Time Stop is especially strong as it can force-disable any target regardless of their Composure value for up to 4sec. All bosses are not immune to this effect. In boss battle, it can be used to escape from paralyzing combo, stop power skill from casting, or even buy time to meditate/blood drain while the boss is stopped for 4sec.
Taichi Counter
Type: Counter
CD: 15sec
Effect: Counter melee attack and deal damage to surrounding AOE. Immune to long range attack while casting.
Cast this when you are expecting a melee attack from your opponent; it will send your opponent flying back. However, while the skill makes you immune to long range attack, it doesn't ward off melee attack. Doing this in mobs crowd is a bad idea.
In summary, the core of ZhenWu skill system revolves around converting Yin to Yang, to unleash powerful combo under Burst Mode. Yin-to-Yang conversion requires the use of Shadow Drive, which consume high amount of Yin. Yin can be recovered by casting certain skills, such as Triple Slash, Sword Wave, Aerial Slash etc.
The combat system of Moonlight Blade Online is easy to learn, yet complex enough to hold players' attention during a real fight. There seems to be many ways to chain combo, with variations to skill effect and animation depending on the skills which are cast before or after. In the next article, I would shed more light on the character and skill growth, including the Nodal System, which will promote skill build variations and skill effect specialization.
Original article by chaose5 for 2p.com


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Lets go Practise Mediicine by PrinceIzumiWatch
©2011-2017 PrinceIzumi
I love you *-* ♥ xD great cosplayss!
I still cannot get over how cool the two of you look in this photograph. Haha. Much love to ya guys, but don't forget about your sandvich loving Heavy over here. ;D
love these!!
you look fabulous <3
YES. So much epic win right here!
Hmm... No spies present?
You guys look fantastic! ...Of course, you always look fantastic.
You look so cool as the Medic, I love the outfit, your pose and the look on your face is great! I hope there is more.
Nice pair! I love the angle of the shot too!
You win todays bad ass award.
You guys are FUCKING FANTASTIC!!!! AHHHHHHHHHHHHHHHH!!!!
AWWW I always love getting comments from you. just that alone makes that cosplay all worth it
VERY awesome cosplays!
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WAAAH! SO SMEXY!!!!!! Good job izumi-san!
So awesome!!! This photo is just fantastic!
You both look perfect in this photo!


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Executive Director, Duke Cancer Institute
Professor of Pharmacology and Cancer Biology
Professor of Pediatrics
Duke University School of Medicine
422 Seeley Mudd Building
Box 3813
Durham, NC 27710
Phone: 919-684-3052
Cellular responses to DNA damage and other stresses are important determinants of cell viability and mutagenesis and impact the development of a wide range of human diseases. The ability to modulate cellular responses to DNA damage and other stresses can impact cancer development, tumor responses to therapy, the organ toxicities of cancer treatments or accidental exposure to radiation or other DNA damaging agents, the development of cardiovascular disease, outcome (extent of organ damage) following heart attack or stroke, and the rate of progression of certain neurodegenerative disorders. The focus of the Kastan lab has long been related to elucidating molecular mechanisms involved in cellular responses to DNA damage and other stresses. This began with studies of changes in DNA methylation and chromatin structure/modification during the process of DNA excision repair (Cell, 1982) and continued with a series of major discoveries demonstrating that the p53 protein, the most commonly mutated gene in human cancer, plays a critical role in enabling mammalian cells to cope with DNA damage, in particular by controlling progression of cells from the G1 phase of the cell cycle into S-phase (Cancer Research, 1991; PNAS, 1992; Cell, 1992) and regulating apoptosis. In the subsequent 20+ years since the discovery of this role for p53, the lab has continued efforts to elucidate molecular mechanisms involved in DNA damage, including cell cycle control, programmed cell death signaling, DNA repair mechanisms, DNA damage-induced signal transduction pathways, and more recently interfaces between cellular metabolism and stress signaling. This has included generating many seminal insights into the roles and mechanisms of action of the ATM protein kinase, including its role in signaling to p53 (Cell, 1992; Genes and Development, 1997; Science, 1998), identifying other ATM substrates involved in DNA damage signaling (Nature, 2000; Genes and Development, 2002, 2004), and elucidating the mechanism of ATM activation (Nature, 2003). In the past several years, the lab has identified a novel and unexpected mechanism involved in the stress-induction of p53, namely a stimulation of the translation of p53 mRNA and recent insights have been gained into the molecular controls of this translational increase (Cell, 2005; Molecular Cell, 2008; Genes and Development, 2010) that are leading to development of small molecules that have the potential to modulate p53 induction after stress and protect normal tissues from radiation, chemotherapy, or hypoxia-reperfusion injury. Recent ATM studies in the lab have focused on molecular controls of DNA double strand break repair (Nature Cell Biology, 2007; PNAS, 2013; Cancer Research, 2015), its role in insulin signaling, metabolic syndrome, and mitochondrial function (Nature Cell Biology, 2000; Cell Metabolism, 2006; PNAS, 2010; Nature Cell Biology, 2013, 2014; unpublished studies), and the development of small molecule inhibitors to be used as clinical tumor radiosensitizers (Cancer Research, 2008; J Biomol Screening, 2014).
Kastan MB, Onyekewere O, Sidransky D, Vogelstein B, and Craig RW. Participation of P53 protein in the cellular response to DNA damage. Cancer Res 51:6304-6311, 1991.
Kastan MB, Zhan Q, El-Deiry WS, Carrier F, Jacks T, Walsh WV, Plunkett BS, Vogelstein B, and Fornace AJ. Jr. A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia telangiectasia. Cell 71:587-597, 1992.
Hartwell LH and Kastan MB. Cell cycle control and cancer. Science 266:1821-1828, 1994.
Canman CE, Lim D-S, Cimprich KA, Taya Y, Tamai K, Sakaguchi K, Appella E, Kastan MB, and Siliciano JD. Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. Science 281:1677-1679, 1998.
Lim D-S, Kim S-T, Xu B, Maser RS, Lin J, Petrini JHJ, and Kastan MB. ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway. Nature 404:613-617, 2000.
Bakkenist CJ and Kastan MB. DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature 421:499-506, 2003.
Kitagawa R, Bakkenist CJ, McKinnon PJ, and Kastan MB. Phosphorylation of SMC1 is a Critical Downstream Event in the ATM-NBS1-BRCA1 Pathway. Genes and Development 18:1423-1438, 2004.
Takagi M, Abasalon M, McLure KG, Kastan MB. Regulation of p53 Translation and Induction after DNA Damage by Ribosomal Protein L26 and Nucleolin. Cell 123: 49-63, 2005.
Berkovich E, Monnat R, Kastan MB. Roles of ATM and NBS1 in chromatin structure modulation and double strand break repair. Nature Cell Biology 9: 683-690, 2007.
Chen, J and Kastan, MB. 5' - 3' UTR Interactions Regulate p53 mRNA Translation and Provide a Target for Modulating p53 Induction After DNA Damage. Genes and Development 24: 2146-2156, 2010.
Alexander A, Cai SL, Kim J, Nanez A, Sahin M, Maclean KH, Inoki K, Guan KL, Shen J, Person MD, Kusewitt D, Mills GB, Kastan MB, Walker CL. ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS. Proc. Nat. Acad. Sci. 107: 4153-4158, 2010.
Valentin-Vega YA, Maclean KH, Tait-Mulder J, Milasta S, Steeves M, Dorsey FC, Cleveland JL, Green DR, and Kastan MB. Mitochondrial Dysfunction in Ataxia-Telangiectasia. Blood 119: 1490-1500, 2012.
Chen J, Guo K, Kastan MB. Interactions of nucleolin and ribosomal protein RPL26 in the translational control of human p53 mRNA. J Biol Chem. 287: 16467-16476, 2012.
Moding EJ, Kastan MB, Kirsch DG. Strategies for optimizing the response of cancer and normal tissues to radiation. Nat Rev Drug Discov. 12: 526-42, 2013. PMCID: PMC3906736
Zhang J, Jinhee K, Alexander A, Cai S, Tee A, Tait-Mulder J, Di Nardo A, Han J, Kwiatkowski E, Dunlop E, Dodd K, Folkerth R, Faust P, Kastan MB, Sahin M, Walker C. A tuberous sclerosis complex signaling node at the peroxisome regulates mTORC1 and autophagy in response to ROS. Nature Cell Biology, 15: 1186-1196, 2013.
Goldstein M, Derheimer FA, Tait-Mulder J, Kastan MB. Nucleolin mediates nucleosome disruption critical for DNA double-strand break repair. Proc Natl Acad Sci 110: 16874-16879, 2013.
Guo K, Shelat A, Guy RK, Kastan MB. Development of a Cell-Based, High-Throughput Screening Assay for ATM Kinase Inhibitors. J Biomolecular Screening 19: 538-546, 2014.
Goldstein M, Kastan MB. Repair versus checkpoint functions of Brca1 are differentially regulated by site of chromatin binding. Cancer Research 75: 2699-2707, 2015.
Zhang J, , Tripathi DN, Jing, J, Alexander A, Kim J, Powell RT, Dere R, Tait-Mulder J, Lee J-H, Paull TT, Pandita RK, Charaka VK, Pandita TK, Kastan MB, Walker CL. ATM Functions at the Peroxisome to Induce Pexophagy in Response to ROS. Nature Cell Biology 17: 1259-1269, 2015.


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Biomimicry Institute
Biomimicry 3.8 is excited to announce the official release of our first online course in the Foundations of Biomimicry series, "Introduction to Biomimicry." This interactive online course has been specifically developed for professionals, students, and others new to the discipline who want to take the first step in understanding and developing a practice in biomimicry.
The course is the definitive online introduction to the world of biomimicry, an immersive experience featuring Dr. Dayna Baumeister, Keystone and Co-founder of Biomimicry 3.8, as your instructor, and nature as your mentor.
For more information, or to enroll, visit: biomimicry.net/foundationalcourses


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Bonsai Drainage Mesh - 24cm x 24cm
Seeds for Africa
Bonsai pots tend to have large holes for drainage hence the need for mesh to keep the growing medium in place. The small holes in the mesh allow water to drain naturally holding the soil in place for good tree health.
The size is 24cm x 24cm. Please note that the mesh is handcut and accordingly there can be small variances in the size by 1cm.


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DOUGIE HAMILTON Team Canada Hockey 2011 UPPER DECK WORLD OF SPORTS CARD # 158
- Sold for: Start Free Trial or Sign In to see what it's worth.
- Item Category: Sports
- Source: eBay
- Sold Date: Feb 23, 2013
- Channel: Auction House
Card is from: 2011 UPPER DECK WORLD OF SPORTS CARDCARD MEASURES: 2 1/2 x 3 1/2 inches standard trading card size CARD CONDITION: NMMT to MINT condition, pack fresh Please visit our eBay store for more sports cards and 1000s of other great items! SHIPPING: PAY SHIPPING ONLY ONCE!
YOU PAY THE SINGLE HIGHEST SHIPPING CHARGE ON YOUR ORDER AND THE REST SHIPS FOR FREE! If buying multiple items, please use the buy it now on all your selected items but wait to pay as you will be provided a total with combined shipping through eBay checkout. Please visit our eBay store for 10,000s of other great items, and probably many similar to this one: POP CULTURE PARADISE


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Tennessee Gas Pipeline Company, L.L.C. (TGP), a subsidiary of Kinder Morgan Energy Partners, L.P., has completed a successful open season for incremental, north to south natural gas transportation capacity on the TGP system totaling 500,000 dekatherms per day (Dth/d).
A binding open season closed Dec. 11, and 400,000 Dth/d of long-term capacity and 100,000 Dth/d of short-term capacity was awarded to six different shippers. The awarded capacity will provide firm transportation service for Marcellus and Utica production from receipt points as far north as Mercer, Penn., for delivery to multiple delivery points on the Gulf Coast. Capital expenditures are approximately $150 million. Capacity bids were for volumes well in excess of the capacity offered and TGP will be evaluating further capacity expansions.
Kinder Morgan Energy Partners
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Applebuckin' by SymphoniaMelodyWatch
©2012-2017 SymphoniaMelody
I'm finally starting to do a decent job with these markers. The fun has been doubled!
Yeehaw, ah'ma gunna git all dem apples!
i love your style, awesome work!!
Thanks! Right now I'm working on a "dapper dash" and Pinkamena. The rest of the Mane 6 (And background characters, of course!) will be coming soon!
For this awesome drawing, you win 7 season 3 episodes ^^


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Welcome to My Personal Finance Journey! If you are new here, please read the "About" or "First-Time Visitor" pages to find out more about us. If you would like to receive free updates on articles like this by email, then sign up here or you can subscribe to the RSS feed. Also, check us out on Twitter or Facebook. Thanks for visiting! Keep on learning!
The following is a post by MPFJ staff writer, SK. SK writes about the reasons we get into debt, changing the patterns that get us into debt, and examines small business ownership and real estate investing at her blog, American Debt Project.
All of those moving costs, new furniture, and security deposits have added up over the years. But when it comes to security deposits, I have finally figured out how to protect myself as a tenant in order to receive the maximum security deposit when I move out. Here are the lessons I have learned over the years when it comes to getting your landlord to refund your deposit promptly:
Know Your Rights
- How long the landlord has to return your security deposit (In California it is 21 days)
- What can and can't be taken out from your security deposit (unpaid rent-yes, replacing a carpet with normal wear and tear-no)
- How much can be charged for certain items: In California, landlords can deduct the cost of cleaning or repairs to original condition up to $125 without sending you an itemized invoice. If you knew this, it would be a lot easier to dispute a $175 cleaning fee.
Document Everything
Before you relinquish the keys, take note of every possible item that you might be charged for and if possible, have an approach to not getting charged for it. I was really nervous that my landlord would charge me for the damage to the corner of a cabinet that my dog had chewed. Thankfully, she didn't charge me anything, but if she had, I would be protected from paying the entire cost of the cabinet, since the cabinet was not new upon move-in. Knowing these things made me more comfortable and ready to handle any charges that might come my way.
Start with the Friendly Approach
However, in the apartment before this one, the process was not as easy. The management company not only didn't want to return my $300 security deposit, they wanted another $600, most of which was for replacing a carpet and damage to the paint. When I got that notice, I was inflamed. I tended to get more angry back then! I immediately started writing an angry, righteous letter detailing all of the reasons why I didn't owe them, they owed me. Later that day, I told my friend, who is a politician, about the issue. He spends all day negotiating with people and making people feel good. I figured whatever advice he gave me would probably work. He immediately told me not to send the letter. "Why don't you go down there and talk with them?" He told me to go in with an easy, friendly approach, and if I showed them I hoped they would help me, they would be more willing to be reasonable than if I had sent an angry letter.
So, I went in and spoke with one of the community managers (it was a huge complex) and it worked! They charged me $100 for cleaning, and I got my $200 security deposit refund back a couple weeks later. Lesson learned: don't start off on the defensive when someone is holding your money. If you're reasonable, they can be reasonable too (most of the time).
How about you all? Do you have any great tips on getting your maximum security deposit back?
Share your experiences by commenting below!
***Photo courtesy of http://www.sxc.hu/photo/1365469


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i never liked wallabees but yours i just hate.. looks like clown shoes no disrespect to wu wally magician2 Weeks ago in Brands
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the meaning of life is to keep living2 Weeks ago in Off Topic
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For course advice call 0345 658 8990 | firstname.lastname@example.com
In return we can offer you a rewarding career working with people equally committed to improving the prospects and skills of the local community.
Here are some of the reasons to consider a career with Tresham:
We are committed to delivering an outstanding learning together and we do this through our 5 values…
Transform – We embrace change.
Esteem – We respect and recognise our people.
Aim High – We aim high.
Collaborate – We collaborate and work together.
Heart – We put learners at the heart of everything we do.
At Tresham, each month all staff have the opportunity to nominate individuals or teams that they feel have gone the extra mile, displaying one or more of our core values. Winners are selected at random from the monthly nominations to receive gift vouchers, plus there are annual awards.
As part of our commitment to staff health and wellbeing, the College has teamed up with Medigold Occupational Health Services to support staff that may require adjustments or other support to enable them to carry out their roles effectively or to support a healthy work/life balance. We also have free health workshops, a dedicated Wellbeing Resource Centre, an Employee Assistance Programme, and supportive workplace policies
At Tresham we offer a range of benefits and incentives for our team members including Perkz (discounts and special offers), Childcare vouchers, Local Government and Teachers' Pension schemes, Healthcare schemes, generous holiday entitlements, above statutory maternity, paternity and adoption pay, on-site gym facilities and a 'Give As You Earn' scheme where you can give directly to your chosen charity from your monthly pay and save tax on your donations.
We have a genuine commitment to equality of opportunity for our staff and our learners, with a dedicated E&D Committee that meets every term to review progress and set objectives and actions for continued improvement. For more information about our E&D policy please click here.
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or browse our full range of courses:
or browse our full range of courses:


text:
Papa John's Fritos Chili Pizza: Genius or Heinous?
Papa John's new Frito pie: The end of the world as we know it.
Papa John's
Papa John's has just announced a new product that could either be the next big thing or the start of end times.
According to the Papa John's website, this limited-edition pizza is topped with beef, chili, Roma tomatoes, onions, cheddar, mozzarella, and Fritos.
Seeing is believing, but eating is even Better. Introducing the Fritos Chili Pizza. https://t.co/nzEvvZmIb2
— Papa John's Pizza (@PapaJohns) October 29, 2014
My first thought? Those poor Roma tomatoes deserve a better fate than to be glopped onto this pizza. My second thought? As gross as it sounds to some, it's manna from heaven to others. The pizza, which sells for $12 for a large pie, is already getting major buzz on Facebook and Twitter for its outlandish recipe that combines a Frito pie with a pizza pie.
While some tout this as an amazing invention:
The new Frito Lay's pizza from @PapaJohns is wow cc: @PepsiCo $PEP pic.twitter.com/wh1Sh5hv1k
— Brian Sozzi (@BrianSozzi) October 29, 2014
Others, well, not so much:
The Frito pie, while repulsive to some (like Anthony Bourdain, who got heat for saying a Frito pie was "as American as apple pie or the Manhattan Project -- and just as deadly), is a piece of Americana to others, especially people out west.
Is the Frito pie an abomination? Yes, if you're a pizza purist. But, before you make judgments, take into account for a moment that true, authentic Neapolitan pizza started out with dough, tomatoes, and fresh buffalo mozzarella. Now, thanks to the tastes of tourists who flock to the city in the Italian southern region of Campania, you'll find all sorts of bastardized versions of the classic pies, topped with sausage, beef, even pineapple at one particular tourist trap. Could chili and corn chips be far behind? I shudder to think so.
Follow Laine Doss on Twitter @LaineDoss and Facebook.
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With it s skilled specialists in all fields, DCS is able to offer you a high quality personalised service according to your requirements.
- William Murphy
- 1 years ago
- Views:
1 With it s skilled specialists in all fields, DCS is able to offer you a high quality personalised service according to your requirements.
2 Data Conversion Service SA, referred to henceforth as DCS is a service company based in Geneva, Switzerland, since It has a workforce of more than 150 in Switzerland, Germany and South America. DCS provides services including outsourcing, digitisation, and data entry, as well a permanent and temporary recruitment. DCS has a highly diverse client base: international organisations, multinationals, chemical industries, teaching hospitals, small/medium companies, etc Our sectors of activity : Facilities management With facilities management, you sub-contract all or part of an IT department while retaining control. Outsourcing Are you looking for quality of service and continuity? Externalise! Digitisation / Archiving DCS digitisation Centre employs experienced staff, who are able to process your documents with care, while maintaining total confidentiality. Recruitment Experienced in the IT, administrative and commercial sectors, we place our professionalism at your service. Data Entry We have a multi-station system making it possible for us to carry out data entry and verification, guaranteeing optimum quality.
3 Need more informations? Contact us!
4 Labor omnia vincit improbus Hardwork conquers all. The Géorgiques of Virgile ISO 9001 Certified since Switzerland Data Conversion Service SA 6, rue de l Aubépine Case Postale Genève 4 Germany Data Conversion Service SA c / AUREN Treuhand GmbH Haidelweg München Chili Data Conversion Service SA Direcction San Antonio 19 Piso 21 of Santiago Tel : Fax : Tel : Fax : Tel : Fax :
5 Facilities management Outsourcing Facilities management Externalisation of services- SLA Service desk - helpdesk - IT Support Remote familiarisation System and network administration Security management Database administration Development Asset management Logistical service What is it? Above all, it is a partnership based on trust. You sub-contract all or part of an IT department while retaining control. We take full responsibility for it: management, day-to-day operations, fluctuations in workload, and any recommendations concerning updates and development. Simulation and installation We can provide you with a simulation of such a service, in terms of both team structure and costs. The DCS approach is based on its experience. Our consultants and engineers analyse the requirements in cooperation with your departments in order to draw up a list of specifications. While defining the best practices for the outsourcing of services, DCS will draw up an agreement protocol or Service Level Agreement (SLA), which will make it possible to organise this service and achieve its objectives. Development You want to develop a specific application, or to automate repetitive tasks. We undertake the development work upon request, either on-site or off-site, using our experienced personnel. Exemples de matériels, systèmes, outils et autres techniques que nous avons déjà pris en charge : Equipment: servers, desktop, mobile equipment: Dell, Sun, HP, Compaq, Digital, Macintosh, SAN, Operating systems: Solaris, Linux, MS-Windows, MacIntosh, Networks: routers and switches - Cisco, WAN, LAN, VPN, DHCP, Firewall, sniffer, Software: OpenOffice, MS-Office suite, Remedy, Autocad and other CAD software, Matlab and other scientific software, Databases: Oracle, Sybase, MySql, MS-Access, BAAN, Messaging: sendmail, Exchange, Development language: C, C++, PHP, python, perl, Others: video conferencing, backup, printers, fax, Alcatel telephone system,
6 Facilities management Do you want to use facilities management? Do you want an assurance that your IT department will run properly regardless of staff absence? Do you want to adapt resources depending on your workload? Is your personnel s knowledge base sufficiently broad to cover any type of operational or development task? Is your business ready to enter into a partnership based on trust? Do you agree to entrust the running of all or part of your IT department to a specialised service provider? Would you like to benefit from the most widespread and recognised IT quality procedures (ITIL)? Do you want your IT personnel to be always up to speed on the latest technological developments? Do you want a personalised level of service (Service Level Agreement), the standards for which can be determined by prior agreement, with a constant level of quality? Do you agree that the service company should assume responsibility for the selection of IT personnel? Do you agree to have at least one monthly meeting, lasting between 30 minutes and one hour, to share your observations and expectations with us? Do you want to know how much your IT department is costing you? Would you like to benefit from the sharing of resources? Would you like IT procedures to be documented so as to ensure continuity of service? Would you like to have a dedicated contact to provide the interface between you and the department?
7 Outsourcing / Externalisation Outsourcing Facilities management Externalisation of services Cost control Service contract (SLA) Guarantee of service Management of resources by DCS Service desk Sub-contracting What is it? Above all, it s a partnership based on trust. You sub-contract out a department (administration, secretarial, reception, switchboard, administrative and IT management, to name but a few). We take full responsibility for all this, namely: management, day-today operations, and fluctuations in workload. Why? Cost control: you know exactly how much this service is costing you. You can adjust this figure to suit your short- or medium-term requirements much more easily than with an in-house team. The defined level of service and its continuity will be adhered to regardless of the absence of personnel and the workload. What is more, at all times, the service may be adapted to meet your requirements and schedules. The adaptability and versatility of the personnel. This type of provision applies regardless of the size of the service on- or off-site. Simulation and installation We can provide you with a simulation of such a service, in terms of both team structure and costs. The DCS approach is based on its experience. Our consultants and engineers analyse the requirements in cooperation with your departments in order to draw up a list of specifications. While defining the best practices for the outsourcing of services, DCS will draw up an agreement protocol or Service Level Agreement, which will make it possible to organise this service and achieve its objectives.
8 Outsourcing / Externalisation Would you like to opt for outsourcing? Is your company ready to enter into a partnership based on trust? Do you agree to entrust the running of the department concerned to a specialised service provider? Do you agree that this service provider should assume the responsibility of selecting personnel? Do you agree to have at least one monthly meeting, lasting between 30 minutes and one hour, to share your observations and expectations with us? Do you have difficulty replacing absent personnel? Do you have level of staff turnover that necessitates regular recruitment? Do you want a personalised level of service (Service Level Agreement), the standards for which can be determined by prior agreement, with a constant level of quality? Do you want to simplify your work? Is planning management too onerous for you? Does managing the personnel in this department represent a significant responsibility? Would the time you spend managing and supervising this department be better employed on other duties? What is the costs and workload connected to the introduction of a new recruit? What will be the return on investment in terms of cost and time? How much is this department currently costing you (fringe benefits, perks, time spent managing personnel, recruitment, training, holiday cover, sickness cover, etc..)?
9 Digitisation / Archiving Digitisation - Scanning Archiving Processing control Indexing OCR - Optical Character Recognition Barcodes - Optical reading Inventory Creation of web page - XML Metadata Integration into an EDMS Our services The DCS digitisation Centre employs experienced staff, who are able to process your documents with care and expertise, while maintaining total confidentiality. Each operation is supervised by a project manager and is subject to quality control. We also travel to our clients sites with our own equipment in order to carry out mass recovery of your documents. We scan documents such as: single sheets, books, plans, photographs, negatives, and microfilms, amongst others, whether they are destined for archives, distribution on the Internet, or for your own applications. We can perform Optical Character Recognition (OCR) on images obtained by digitisation. This allows you to find your documents according to their content, by doing a search on the text. These digitised documents are restored in various formats and using diverse media: Word, Excel, PDF, TIFF, Database, etc on CD, DVD, Internet (secure access), Intranet, integration in your applications, etc plus encryption option. Undertaking our scanning work in direct proximity of your premises, we effectively limit transportation related risks for your documents. They do not leave the country.
10 Digitisation / Archiving Why digitise? To ensure the permanent safety of your documents. For rapid access to digitised data with no distance restriction. To resolve problems with the storage of documents and to free up space. To distribute information to the relevant users. To avoid the handling of paper which involves the risk of loss or damage. To manage your live or archived documents electronically by means of an index. To increase the performance levels of the departments concerned (saving time). Examples of applications within different departments : Front-office Client files Documentation Correspondence Financial and legal Accounting documents Legal documents Legal affairs Purchasing Invoice Contracts Tenders and documentation from suppliers Human resources Personnel files Applicants dossiers Administrative documents Documentation Collection of documents Books and press reviews Surveys and statistics
11 Permanent and temporary recruitment DCS offers a personalised service for your recruitment of permanent and temporary personnel. Experienced in the IT, administrative and commercial sectors, we place our professionalism at your service. What makes us different Through our varied high-technology activities in demanding environments, we are able to make a precise assessment of the skills of the applicant on offer. Our role is to carry out a strictly defined and highly focused selection procedure so as to guarantee you a perfect match between the vacant position and the new employee. Our objective: to help you save time. Temporary work Placed directly at our clients disposal, our personnel are able to carry out various duties within the company at very short notice. As a priority, we delegate employees who are part of our team of preferred temporary workers.
12 Data Entry Data Entry Data processing Coding Creation of database Statistics Surveys to be entered Verification of data Since 1973, DCS have been specialists in data entry. We have a multi-station system making it possible for us to carry out data entry and verification, guaranteeing optimum quality. This data is reconstituted in various formats (for example: ASCII, EXCEL, ACCESS, etc.) and using physical media (CD, DVD, etc.) or on line. There is the option of combining data entry with digitisation. References in highly diverse fields : Medicine, finance, industry, universities, International organisations, etc.
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