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For those of you unable to get a prescription for phentermine, the idea of 'natural phentermine' might seem like the perfect alternative: the weight-loss benefits of phentermine, all-natural ingredients and no need to get a prescription. However, it's important to know exactly what you're buying into, and what you're putting in your body when it […]Read more
Since it was first approved by the FDA in 1959, phentermine has helped millions of people lose weight, and for this reason it's still the most widely prescribed weight loss medication in the US. However, if you're unsure about how phentermine works, we're here to explain everything you need to know to feel fully informed […]Read more
If you've been searching for a solution to help you lose weight, then it's likely that you will have looked into the possibility of taking diet pills to give you the results you want. Phentermine is the leading weight loss prescription medication in the US, but you may be wondering if phentermine is right for […]Read more
Here on the phentermine.com blog we do our best to provide answers to your phentermine questions by publishing quality articles specifically designed to help keep you informed about phentermine. However, to make it easier for you to find out exactly what you want to know, here we have put together some of the most common […]Read more
People are often keen to know whether their experiences with phentermine are 'normal', but we're all unique and therefore our experiences with phentermine can vary a lot. When it comes to a medication like phentermine, patients have to consider how individual differences will influence many aspects of their experiences with phentermine, including side effects and […]Read more


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Edgy Exegesis
Bridesmaids, The Time is Now: Reflections on Matthew 25:1-12
Lectionary Reflections on Matthew 25:1-12
The Parable of the Ten Bridesmaids
Sunday, November 7, 2011
One of the themes dear to Matthew's heart is the theme of the anticipation of coming judgment. It is important for him to emphasize to his community two things with regard to Jesus' return. One is that they don't know when it will come, so speculation is futile. The second is that it will come, so preparation is crucial. In the parable of the Faithful or Unfaithful Slaves that directly precedes the parable of the closed door, the Master comes back sooner than the slave anticipated and found him abusing his powers. In this parable, the Bridegroom comes later than the foolish bridesmaids anticipated and they had not gathered the provisions needed to welcome him.
We are often unprepared for what comes next in life, despite our constant preoccupation with the future. Sometimes a premature ending takes us by surprise. At other times, we are unprepared for something to take longer than we had anticipated. In the former case, we think we have all the time in the world, to mend a relationship, to achieve an important goal, to discontinue a bad habit or begin a good one, to take care of ourselves, to develop our relationship with God, to read important books, to take a stand, to show we care. My paternal grandmother lived to be 95. My father looked very much like his mother, so naturally, I just always assumed that he, too, would live to be 95. Until he got liver cancer at age 74 and died at age 76. I felt robbed of 20 years. Where is the time now to express my appreciation to him, to call him and ask his advice on this or that? We have all the time in the world to spend time with our kids. Except somebody sped up the clock, and now their rooms are empty and we get the sinking feeling that a ship has sailed that will never return to port. There I go mixing metaphors again, but I have a lifetime to get over that bad habit and all my others as well.
I was once in a hotel workout room, its sole occupant, walking on the treadmill in between meetings and reading a light novel. A man came in and got on the elliptical machine. He tried watching CNN for a while, but soon got bored and so became determined to engage the only other person in the room in conversation. "My wife makes me come down here everyday. I hate this. What are you reading?" I showed him the cover. "You seem pretty fit, but you won't live forever," he said to me. "Shouldn't you be reading something more important?" I started to point out that he hadn't brought anything to read at all, but put aside the impulse. He was right. I may live quite a while, but I will die not having read all the important books. Maybe there is more urgency to try than I usually feel.
Rabbi Eliezer taught his disciples, "Repent one day before your death." One of them then asked, "How will we know when that day is?" To which he replied, "All the more reasons to repent today, lest you die tomorrow."
In the parable of the closed door, the problem was not the surprisingly quick return of the master, but his surprising delay. The bridesmaids, the 5 foolish ones anyway, were not prepared for the long haul. Many of us don't have health habits made for the long haul. We have fad diets and sporadic exercise regimes. Many of us don't participate in friendships for the long haul, but allow geographic changes to end friendships we thought would be lifelong. Even though life and the world may seem to go on forever, a day is coming when there will be no more second chances to do certain things or to cease doing others.
Alyce M. McKenzie is the George W. and Nell Ayers Le Van Professor of Preaching and Worship at Perkins School of Theology, Southern Methodist University.
McKenzie's column, "Edgy Exegesis," is published every Monday on the Preachers Portal. Subscribe via email or RSS.

subset: commoncrawl


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Gwyneth Paltrow's in a Bikini Again
STEVEN: "It'll be a blast. We'll have a security detail, lifeguards, fruity ice pops, a guy grilling burgers for us, and I'll be taking video of everything. Bring the kids!"
GWYNETH: "All-NATURAL fruit pops?"
STEVEN: "That can be arranged."
GWYNETH: "Yay!!"
Hmmm….Gwenny got an N/A.
Nice ass? Nope. Negative Ass.
I'd hit it. And miss.
SpongeKate SquareSkirt
Sheik FTW!!!
GooP: Extremis


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Remodeling of central metabolism in invasive breast cancer compared to normal breast tissue – a GC-TOFMS based metabolomics study
Changes in energy metabolism of the cells are common to many kinds of tumors and are considered a hallmark of cancer. Gas chromatography followed by time-of-flight mass spectrometry (GC-TOFMS) is a well-suited technique to investigate the small molecules in the central metabolic pathways. However, the metabolic changes between invasive carcinoma and normal breast tissues were not investigated in a large cohort of breast cancer samples so far.
A cohort of 271 breast cancer and 98 normal tissue samples was investigated using GC-TOFMS-based metabolomics. A total number of 468 metabolite peaks could be detected; out of these 368 (79%) were significantly changed between cancer and normal tissues (p<0.05 in training and validation set). Furthermore, 13 tumor and 7 normal tissue markers were identified that separated cancer from normal tissues with a sensitivity and a specificity of >80%. Two-metabolite classifiers, constructed as ratios of the tumor and normal tissues markers, separated cancer from normal tissues with high sensitivity and specificity. Specifically, the cytidine-5-monophosphate / pentadecanoic acid metabolic ratio was the most significant discriminator between cancer and normal tissues and allowed detection of cancer with a sensitivity of 94.8% and a specificity of 93.9%.
For the first time, a comprehensive metabolic map of breast cancer was constructed by GC-TOF analysis of a large cohort of breast cancer and normal tissues. Furthermore, our results demonstrate that spectrometry-based approaches have the potential to contribute to the analysis of biopsies or clinical tissue samples complementary to histopathology.
In a recent update, Hanahan and Weinberg added reprogramming of energy metabolism to the list of hallmarks of cancer
Analytical chemistry methods allow the investigation of the metabolic changes that occur in cancer tissues. Using gas chromatography (GC), liquid chromatography (LC) or capillary electrophoresis (CE) coupled with mass spectrometry (MS) hundreds of molecules in a tissue sample can be analyzed simultaneously. In two preceding studies using gas chromatography followed by time-of-flight mass spectrometry (GC-TOFMS) we successfully profiled ovarian and colon cancer
Breast cancer is a public health issue of global relevance with more than one million new cases diagnosed annually and more than 400,000 death cases worldwide
GC-TOFMS based metabolomics provides a wide coverage of the central part of the cellular metabolism including glycolysis, citrate cycle, amino acid and nucleotide metabolism. These pathways are altered in cancer cells and can be targeted by metabolic drugs. Herein, we report on the comparison of 275 invasive breast cancer samples with 94 normal tissue samples using GC-TOFMS. The purpose of this study is two-fold: (i) to analyze the metabolic changes in the central pathways between invasive carcinoma and normal breast tissues on a global scale and (ii) to identify key metabolic markers that separate cancer from normal tissues with high sensitivity and specificity.
Metabolomics analysis of breast cancer
The entire cohort of breast cancer and normal tissues was divided into a training set (TS, 226 samples, of which 184 were tumor samples) and a validation set (VS, 143 samples, of which 87 were tumor samples). Analysis of the GC-TOFMS spectra of the TS samples led to the detection of 468 most abundant metabolite peaks that were present in breast cancer tissues. Subsequently, these metabolites were measured in the VS. 162 of the detected metabolite peaks could confidently be mapped to known chemical structures and metabolite names.
Using unsupervised analysis methods we investigated the contribution of the malignancy of the tissues to the total variance of the dataset. The results of a principal components analysis (PCA) of TS and VS are shown in Figure
Figure 1
Principal components analysis (PCA) of the GC-TOFMS data
Principal components analysis (PCA) of the GC-TOFMS data. The rotation matrix that connects the 162 identified metabolites with the principal components (PCs) was determined using the TS data. In the TS, the 1st PC captured 34.9% of the total variance; in the VS the 1st PC captured 34.6% of the total variance. The 1st PC was significantly decreased in cancer compared to normal tissues in TS (p = 2.2E-22) and VS (p = 8.4E-41).
Metabolic changes between breast cancer and normal tissue
Metabolite-by-metabolite analysis of the training set (TS) led to detection of 427 significantly changed metabolites between cancer (T) and normal tissues (N). Out of these, 363 (85%) remained significant after Bonferroni correction and 368 (86%) could also be validated by analysis of the validation set (VS). Among the validated metabolites, 247 were decreased and 121 increased in tumors, corresponding to 53% and 26% of the entire set of metabolites detected by GC-TOFMS.
For functional analysis, PROFILE clustering
Figure 2
PROFILE clustering of 129 KEGG metabolites with fold changes between cancer and normal tissues
PROFILE clustering of 129 KEGG metabolites with fold changes between cancer and normal tissues. Ordering of the metabolites along the x-axis reflects the distance of metabolites in the network of enzymatic reactions. Significant metabolite changes in the TS that could be validated in the VS (green) and not significant or not validated metabolite changes (yellow).
A metabolic network was constructed using Cytoscape with MetScape plug-in (Figure
Figure 3
Metabolic map of breast cancer showing alterations in energy metabolism, catabolism of amino acids, nucleotide metabolism and other pathways
Metabolic map of breast cancer showing alterations in energy metabolism, catabolism of amino acids, nucleotide metabolism and other pathways. Networks were generated using Cytoscape with the Metscape plug-in. Significantly increased metabolites in tumor compared to normal tissue (red nodes), significantly decreased metabolites (green nodes), unchanged metabolites (yellow nodes) and metabolites not in the GC-TOFMS screen (white nodes). The size of the nodes is proportional to the absolute value of the fold change.
Strong deregulation occurred in glutamate metabolism with a shift of equilibrium from alpha-ketoglutarate (fold change = -2.1, p = 2.4E-17) towards glutamate (fold change = 6.5, p = 1.6e-40). Nineteen proteinogenic amino acids (all except histidine) could be detected by the GC-TOFMS approach. Out of these 16 were strongly increased in the cancer tissues (all fold changes >1.9, all p-values <5.0e-10). Only one of the detected proteinogenic amino acids, asparagine, was decreased between cancer a normal tissues (fold change = -1.6, p = 1.5e-07), while glutamine and arginine remained unchanged.
Amphiphilic phospholipids are the building blocks of the cell membrane and are synthesized from choline and ethanolamine via the Kennedy pathway. Within this pathway, we have detected a shift of the equilibrium from ethanolamine (fold change = -2.0, p = 0.00041) to phosphoethanolamine (fold change = 16.3, p = 1.8e-44). Nucleotides, nucleosides and their phosphates were generally increased in the cancer tissues with the strongest regulations belonging to CMP (fold change = 10.3, p = 1.4e-57) and AMP (fold change = 7.8, p = 3.4e-49).
Metabolite based separation of cancer and normal tissues
In order to develop a metabolite-based molecular approach for the detection of breast cancer, we analyzed each metabolite for its classifying power. 50 metabolites, of which 20 have a known chemical structure, separated tumor (T) from normal breast tissues (NB) as well as tumor from normal adipose-rich tissues (NA) with sensitivity and specificity >80%. The fold changes of these marker metabolites are shown in Figure
Figure 4
Fold changes of 13 tumor markers and 7 normal tissue markers
Fold changes of 13 tumor markers and 7 normal tissue markers. Each marker separates tumor (T) from normal breast (NB) and from adipose-rich normal tissues (NA) with sensitivity and specificity >80%.
In order to enhance the separation, each of the tumors markers was divided by each of the normal tissues markers yielding 13 × 7 = 91 metabolite ratios that served as classifiers. For each classifier, we defined a cut-off value for the classification in cancer and normal tissues by maximizing the sum of sensitivity and specificity. Then, we applied a voting system counting each of the classifiers above the cut-off +1, and each of the classifier below the cut-off -1. The votes for 91 classifiers were summed and the results are shown in Figure
Figure 5
Metabolite based prediction of the malignancy of 369 tissues
Metabolite based prediction of the malignancy of 369 tissues. 91 classifiers are constructed from the 20 most discriminatory metabolites that are shown in Figure
Next, we compared the classification result obtained by the majority of the classifiers with the histopathological classification that is the gold standard for cancer detection. Only 8 out of 271 tumors and 6 out of 98 normal tissues were classified incorrectly, leading to a sensitivity of 97.0% and a specificity of 93.9% of the molecular test. Further, restricting the analysis to the 319 tissues where more than 90% of the classifiers agreed, only one tumor and four normal tissues were classified incorrectly, leading to a sensitivity of 99.6% and a specificity of 95.5%.
Among all classifiers the ratio of cytidine-5-monophosphate / pentadecanoic acid had the highest significance for changing between cancer and normal tissues (T vs. N: p = 8.3E-74) and at the same time had the highest significance for changing between malignant and normal breast tissues (T vs. NB: p = 7.8E-14). Maximizing the sum of sensitivity and specificity lead to a cut-off value = 0.39. Using this cut-off point, only 14 out of 271 tumors and 6 out of 98 normal tissues were incorrectly classified leading to 94.8% sensitivity and 93.9% specificity. Histogram and ROC curve of the classifier are shown in Figure
Figure 6
Prediction of tissue malignancy by the ratio R = cytidine-5-monophosphate / pentadecanoic acid
Prediction of tissue malignancy by the ratio R = cytidine-5-monophosphate / pentadecanoic acid. (A) Up-regulation of cytidine-5-monophosphate in cancer compared to normal tissues. (B) Down-regulation of pentadecanoic acid in cancer compared to normal tissues. (C) Histogram showing the distribution of the ratio R in cancer and normal tissues (x-axis: log2 scale). R was significantly higher in cancer than in normal tissues (p = 8.3e-74, Welch's t-test). A cut-off at R = 0.39 maximizes the sum of sensitivity and specificity. (D) ROC curve of R with confidence intervals for sensitivity (red lines) and specificity (green lines). The cut-off leads to at sensitivity of 94.8% and a specificity of 93.9% for the separation of cancer from normal tissues.
Nearest centroid classification
We investigated the performance of classifiers including 2, 3, …, 162 metabolites with known structure for the separation of cancer from normal tissues. To estimate sensitivity and specificity of the classifiers, we combined nearest centroid classification with a multiple random validation strategy, as in
Our results show that tissues collected during breast surgery have reproducible metabolite profiles that can be analyzed by using GC-TOFMS. Using this approach, 478 metabolite peaks could be detected and quantified; 79% of these were changed between cancer and normal tissues. Thus, there is a difference in the concentrations of many metabolites between cancer and normal tissues including changes as high as tenfold and more for some metabolites. The high rate of validated metabolites in a predefined training-validation analysis, even after the conservative Bonferroni correction, shows that the GC-TOFMS is a robust approach to detect the metabolite changes associated with malignant progression. Data acquisition at different time points is considered as a main source of variance in many GC-MS studies. However, the high degree of reproducibility (86% of metabolic changes) between training and test data set underscores the robustness GC-TOFMS platform and of the detected metabolic changes in the current study.
A metabolic map of breast cancer was constructed by visualizing the metabolite changes in the metabolic network including pathways like glycolysis, TCA cycle, nucleotide metabolism and catabolism of amino acids. The metabolic map can serve as a tool for hypothesis building about the metabolic processes in breast cancer and help to develop strategies for the therapeutic targeting of metabolism in cancer cells. Several metabolic drugs, some of them targeting the central energy metabolism, are currently under development and investigated in clinical studies
Cancer is commonly considered as a genetic disease that is driven by mutations of oncogenes and tumor suppressor genes. However, one of the major underlying purposes of those genetic and gene expression changes is to create a metabolic phenotype for cancer cells that is essential for tumor cell growth and survival
Glutamine, the most abundant amino acid in blood plasma, can be metabolized to pyruvate and lactate through glutamate, alpha-keto-glutarate and via the citric acid cycle. This process, termed glutaminolysis is an important source of energy, carbon and nitrogen in cancer cells
In the GC-TOFMS metabolomics based approach we observed a two- to four-fold down-regulation of almost all detected free fatty acids (Figure 2). The down-regulation of fatty acids seems to contradict the up-regulation of fatty acid synthase (FASN) and increased
The GC-TOFMS data also showed a shift of the equilibrium from ethanolamine that was decreased to phospho-ethanolamine that was highly increased in the cancer tissues possibly indicating a stimulation of the Kennedy pathway. To correlate these changes with the content of membrane lipids, we have extracted the total content of different kinds of membrane lipids from the UPLC-MS data published before
Figure 7
Heatmaps of glycerophospholipids and free fatty acids
Heatmaps of glycerophospholipids and free fatty acids. (A) Heatmap of ethanolamine and phospho-ethanolamine, both detected by GC-TOFMS, and the total amounts of phosphatidylethanolamine (PE), phosphatidylcholines (PC), spingomylins (SM) and triglycerides (TG), all detected by UPLC-MS. (B) Heatmap of 18 free fatty acids, all detected by GC-TOFMS. The fatty acids are annotated by the number of carbon atoms, the number of double bonds and the omega position of the double bonds. The bars at the top of the heatmaps encode the type of tissue: invasive carcinoma (T) = red, normal breast tissue (NB) = dark grey, adipose-rich normal tissue (NA) = light grey.
In order to develop a classifier that separates between cancer and normal tissues, we identified 13 increased metabolites and 7 decreased metabolites that separated cancer from normal tissues with sensitivity and specificity >80%. We did not detect any perfect biomarker in the sense that a single metabolite was abundant and specific to cancer tissue, but absent in normal tissues or
The metabolite ratio cytidine-5-monophosphate/pentadecanoic acid showed the strongest discrimination between cancer and normal tissues and permitted detection of cancer with a sensitivity of 94.8% and a specificity of 93.9%. Pentadecanoic acid (C15:0) is a known fatty acid present in milk and it has been found to be a good marker of milk fat intake when found in serum. However, a heatmap of the free fatty acids shows a high correlation of the free fatty acids C14:0, C15:0, C16:0, C17:0, C18:0, C20:0 in the METAcancer cohort (see Figure
For the detection of metabolite changes, we worked with a predefined training set (TS) and validation set (VS). All of the 20 most discriminatory metabolites are among the validated changed metabolites between cancer (T) and normal tissues (N). It should be noted, though, that normal breast tissue might consist of normal epithelium as well as various amounts of adipose tissue. Therefore, it was important to distinguish different kinds of normal tissues (NA and NB) and to develop a classifier that is independent of the fat content of the tissue. Thus, only metabolites that separated cancer from both, normal breast (NB) and normal adipose-rich tissues (NA) were included in the final classifier. This part of the analysis could only be performed in the pooled TS and VS due to a low number of normal breast samples. Another limitation of the current study is its retrospective character and the use of preselected samples that were enriched for cancer or normal cells. The cancer classifiers developed here need to be further validated using random samples from biopsying or surgery. In doing so, concordance with histopathology (accuracy) and reproducibility in repeated analyses of the same tissue (precision) of the classifiers should be further evaluated.
A critical factor determining whether a method is applicable for routine cancer diagnostics, for example during surgery, is the time needed for sample analysis. In order to cope with the inherent heterogeneity nature of the tissues, it is necessary to probe various areas of the tissue and still keep the total analysis time in the range of minutes. There is recent progress in automation and miniaturization of MS devices and such tools are expected to become cheaper and easier to handle during the next few years
For the first time, a metabolic map of breast cancer was constructed by GC-TOF analysis of a large cohort of breast cancer and normal tissues. In future, MS based devices could contribute to the analysis of biopsies and surgical samples. While metabolite analyses will not replace microscopic evaluation, metabolomics could be used complementary to histopathology, e.g. for an initial quality control of biopsies directly after sampling or as additional assessment method for biopsies or surgical samples.
Study cohort
The study cohort consisted of 369 fresh frozen breast tissues that were collected at the Charité Hospital in the tissue bank of the European FP7 METAcancer consortium. The project was approved by the institutional review board of the Charité Hospital (EA1/139/05). For histopathological quality control, an H&E section of each frozen tissue was evaluated by a pathologist. 271 samples contained cancer tissue and had a tumor area ≥40% (T), the remaining 98 samples contained exclusively normal tissue (N). The normal tissues included 27 samples with ≥40% normal breast tissue (NB) and 71 adipose-rich samples with <40% normal breast tissue (NA).
As a basis for a predefined training-validation strategy, the entire cohort was divided in a training set (TS) of 184 + 42 (T + N) samples and a validation set (VS) of 87 + 56 samples. In detail, tumor samples were split randomly in a way that training (2/3) and validation (1/3) sets did not differ with respect to the following parameters: tumor stage, tumor grade, age (≤50 and >50 years) and estrogen receptor status. To this end, 100,000 splits were randomly drawn and the one with the lowest Kullback-Leibler divergence was chosen. All 42 normal tissues in the TS were paired with tumor tissues in the TS from the same patients. The VS included 24 normal tissues that were paired with tumor tissues and 32 additional unpaired normal tissues.
GC-TOFMS based metabolomics
GC-TOFMS data acquisition of the 369 tissues was performed as previously published
Principal components analysis
Using unsupervised multivariate data analysis methods, we investigated whether the malignancy of tissues was among the main contributors to the variance of metabolites. To this end, the measurements of each identified metabolite were zero centered and principal components analysis (PCA) was performed. The rotation matrix that connects the 162 metabolites with the principal components was determined from the TS data. By multiplication with the rotation matrix, the principal components were calculated for the TS and VS. Finally, the principal components were investigated for changes between cancer and normal tissue samples. The significance of changes was assessed using Welch's t-test.
Detection of metabolite changes
We performed a supervised analysis and investigated each metabolite for change between cancer and normal tissues. A metabolic change was termed as detected, if there was a significant change in the TS (p < 0.05, Welch's t-test, two-sided). A metabolic change was termed as validated, if there was a significant change in the VS in the same direction (p < 0.05, Welch's t-test, one-sided). Using PROFILE clustering, the detected metabolite changes were analyzed in the context of the underlying metabolic pathways. PROFILE clustering is a bioinformatic method that groups metabolites with respect to the topologic distance within the metabolic network
Network reconstruction and visualization
A metabolic network was generated using Cytoscape
Marker metabolites and cancer detection
Separation of tumors (T) from normal breast tissues (NB) and tumors from adipose-rich tissues (NA) were investigated using receiver operator characteristics (ROC) curves. Metabolites that exceeded 80% sensitivity and specificity for both comparisons were considered as classifying. Classifying metabolites were divided in tumor markers (increased in T) and normal tissues markers (increased in NB and NA). Classifiers were constructed by the ratio of each possible combination of a tumor and a normal tissue marker. The quality of each classifier was investigated in an ROC analysis. For each classifier, an optimal cut-off point was determined by maximizing the sum of sensitivity and specificity. A voting system was applied counting each of the classifiers above the cut-off +1, and each of the classifier below the cut-off -1. Finally, each of the tissues was predicted to belong to the class with the majority of votes.
Multiple random validation strategy
We investigated the performance of classifiers including 2, 3, …, 162 of the metabolites with known structure for the separation of cancer from normal tissues. For each of the metabolite numbers 200 random splits of the GC-TOFMS data were drawn. All training data sets included the same number of tumor and normal tissues (65 of each tissue type). Classification was performed by the nearest centroid method with respect to euclidean distance after feature selection based on Welch's t-test. All analyses were conducted using the R package
Competing interests
The authors have no competing interests to declare.
Authors' contributions
JB, CD and OF designed the study; RMS, JLG and MO contributed to the design of the study. CD, MD, CRE and UM collected and annotated tissue samples. CD, BMM, SFB and UM did the histopathological evaluation of the samples. GW and OF converted the GC-TOFMS spectra to metabolite data. JB analyzed the metabolite data; FK, BG and MH contributed to data analysis. JB wrote the manuscript. All authors read and approved the final manuscript.
This work was funded by the European Commission, FP7 grants #200327 (METAcancer) and #257669 (ARROWS).
Hallmarks of cancer: the next generation
On the origin of cancer cells
Metabolic transformation in cancer
Understanding the Warburg effect: the metabolic requirements of cell proliferation
Thymidylate synthase as an oncogene: a novel role for an essential DNA synthesis enzyme
Metabolic profiles of cancer cells
Fatty acid synthase and cancer: new application of an old pathway
Molecular causes of the aberrant choline phospholipid metabolism in breast cancer
Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis
Tumor cell metabolism: cancer's Achilles' heel
Rethinking the Warburg effect with Myc micromanaging glutamine metabolism
Targeting metabolic transformation for cancer therapy
Novel theranostic opportunities offered by characterization of altered membrane lipid metabolism in breast cancer progression
Metabolite profiling of human colon carcinoma–deregulation of TCA cycle and amino acid turnover
Mass spectrometry-based metabolic profiling reveals different metabolite patterns in invasive ovarian carcinomas and ovarian borderline tumors
FiehnLib: mass spectral and retention index libraries for metabolomics based on quadrupole and time-of-flight gas chromatography/mass spectrometry
Breast cancer
Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials
Triple-negative breast cancer
Present and future evolution of advanced breast cancer therapy
Prediction of cancer outcome with microarrays: a multiple random validation strategy
Why do cancers have high aerobic glycolysis?
Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis
Metabolism and action of amino acid analog anti-cancer agents
Targeting mitochondrial glutaminase activity inhibits oncogenic transformation
Prognostic relevance of gene amplifications and coamplifications in breast cancer
Choline kinase and its function
Miniature mass spectrometer systems based on a microengineered quadrupole filter
Miniature mass spectrometers
Hand-portable gas chromatograph-toroidal ion trap mass spectrometer (GC-TMS) for detection of hazardous compounds
The metabolomics standards initiative
KEGG for integration and interpretation of large-scale molecular data sets
Cytoscape: a software environment for integrated models of biomolecular interaction networks
Metscape: a Cytoscape plug-in for visualizing and interpreting metabolomic data in the context of human metabolic networks


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DeWalt | SKU: T22676 | Model: DCS391B
20V Max Circular Saw (Tool Only)
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I get the urge to go up to the lake and know that it is soon that I can again do that. I have spent countless hours there over the span of my entire life in this town of Fairfield, CT. and it is always such a place of territorial memories. I have walked there as a child, as a young girl, as a young adult. I have walked there pregnant, angry, hopeful, wistful, energetic, magical, depressed...every emotion possible has been seen in that familiar expanse of forest. I have walked there with babies strapped on my back while walking big dogs, and I chose it as the place where I would lose 30 pounds after I learned of my significant weight gain around 2006.
I had quit smoking in 2004 and gained 50 pounds. I went to a Weight Watchers meeting with my mother, who is a lifetime member and cried when I saw the number on the scale. So not only was I grappling with overcoming a seventeen year addiction, now I was the size of a small whale.
So, again, I retreated to the forest to heal...
What took place in time after that was a rude awakening to what I had been covering with the smokescreen of addiction - so many issues and memories, just like we all know and have, came spilling out of an unstoppable volcano of emotion, mostly anger and mainly regret.
What I now know about it, and think that I understand about it, is what this blog needs to be dedicated to because I have spent countless hours in the pages of journals, both online and off, talking to myself about my particular demons and ways to either honor them or just live with them, accepting them as parts of me, integrating them and just watching them be what they are until I can figure out how to best use them creatively...which has always been my goal.
It is by the multitudes of mistakes I have made that I can truly recognize the growth that has occurred and allows me to have faith in a better future. So instead of feeling crazy about all of this, I am grateful for the hindsight that allows me to cull a great deal of inspiration from the lessons learned. I am also grateful for those of you who have been reading along with me the whole time...or are just starting to now.
Until next time ~ xo 333 xo
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Carole Anzolletti quit a 17 year habit of smoking cigarettes on November 1, 2004


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I know this sounds a little odd, but Hugh Hefner should encourage Los Angeles authorities to leave the Hollyweed prankster alone (or maybe cover his legal fees).
Welcome to 2017 #hollyweed pic.twitter.com/NJwkSfDT6U
— Jay Mendoza (@MrJayMendoza) January 1, 2017
As you probably know, someone went up to the Hollywood sign on New Year's night and changed it to say "Hollyweed." How many people did this harm? Zero. Should this prankster be prosecuted? No. Who should argue for that? Hugh Hefner. Why? Let me explain.
Back in 2010, Hugh Hefner donated nearly $1 million to save the Hollywood sign. Developers were trying to take over the land and turn it into space for mansions, because, well, developers are often scum. Hefner saw this travesty taking place and donated $900,000 to a nonprofit trying to buy the land to save it.
"It would have been a real shame after having restored it if it wound up sold," Hefner said at the time. "It's become something iconic and represents not only the town but represents Hollywood dreams, and I think that's something worth preserving."
Now the LAPD is saying the prankster may be prosecuted. Considering no one was hurt, the sign doesn't seem to have ben damaged and it was a holiday known for pranks, it seems ridiculous to lock this guy up or give him a huge fine for this. If Hefner really loves the sign and the Hollywood dream, he should help this guy get a break.
[Photo by Alan Light/Flickr]


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In just two weeks, United Front Games' long gestating Sleeping Dogs will finally see the light of day. In development since 2009, and originally announced as True Crime: Hong Kong before being killed by Activision and resurrected by Square Enix, Sleeping Dogs is a hyper-violent take on the open-world genre, set in picturesque Hong Kong.
A brand new trailer, "Hard-Boiled Gunplay," shows off exactly that. If you caught the John Woo reference in the trailer's title, or you're any kind of Hong Kong action cinema fan, Sleeping Dogs could be just the game for you.
Under-cover cop Wei Shen is certain to have his hands full as he works to take down the Sun On Yee Triad. Fortunately for him, those hand happen to double as deadly weapons. United Front Games brought in MMA champion Georges St-Pierre to help fine tune Sleeping Dogs' brutal hand-to-hand combat — combat that looks to be more varied and visceral than in any other open-world game (look no further than the cranial trauma on display in the "Sleeping Dogs 101″ trailer for proof). Still, it's going to take more than Shen's fists to topple the Triad. Needless to say, that's where the guns come in.
The "Hard-Boiled Gunplay" trailer touts Sleeping Dogs' "aggressive cover system," its "explosive and destructible environments" and its "high speed shootouts," but mostly, it shows scene after scene of Shen shooting up stuff, but good: bad guys, aquariums, cars and more. Unfortunately, the trailer doesn't elaborate much on Sleeping Dogs' Max Payne-esque "slow motion" feature, nor does it give a clear picture of how gunplay is handled mechanically — there is, for instance, no targeting reticle on display. Then again, the lack of user interface elements certainly makes for a good looking trailer, so who's complaining?
August is probably not the month most players head to their local games retailer looking for a marquee title, and the verdict is still out on Sleeping Dogs. That said, kudos to Square Enix for giving the game a chance to find an audience before the holiday onslaught begins in earnest little more than a month from now.
Ranters, what do you think of Sleeping Dogs' serious, and seriously violent, take on the open-world genre? Are you looking forward to the game? Leave your thoughts in the comments below.
Sleeping Dogs releases August 14, 2012, for Xbox 360, PS3 and PC.
Follow me on Twitter @HakenGaken.


text:
NOTE: Recruitment for the Fall 2016 – Spring 2017 ended on April 5, 2017 at 11:45 p.m. For information regarding recruitment for Fall 2017 – Spring 2016, email email@example.com
A nationally recognized and award-winning college newspaper, The Signal focuses on providing quality, timely and accurate reporting on the city of Atlanta and the community of Georgia State University. The university now boasts the second largest number of in-state alumni and thousands of faculty and administrators.
How to sharpen your skills
Whether you're a writer or a photographer, working for The Signal will help you improve the quality of your craft.
How to work effectively as a team
Reporters, photographers, designers and editors collaborate to produce a newspaper everyone can take pride in.
How to meet deadlines
One of the most important concepts of journalism, deadlines hold everyone responsible for their own work in order to put the paper out every week.
How to use your resources
Through social media, library research and countless phone calls, staffers at The Signal learn quickly how to obtain the information they need.
Reporters write at least one story a week covering Georgia State and Atlanta, constantly sharpening their journalistic skills.
Photographers have the opportunity to capture live news and learn the skills to tell a story with your photographs.
Designers use their ingenuity and innovation to keep the paper looking fresh as they master InDesign, Illustrator and Photoshop.
Illustrators use their imaginations as they create eye-catching artwork and sarcastic political cartoons.
Marketing staffers create inventive campaigns to publicize the newspaper to attract advertisers
Advertising works with internal and external clients to boost exposure to the Georgia State community through The Signal's resources.
Podcasting publishes once per week bringing students information from The Signal through a different medium.
*All majors welcomed. The Signal accepts any work done in class as clip samples.
[powr-button id=3152920a_1470075873289]


text:
Well to miss out on pair
By Peter ORourke
Last Updated: 01/01/70 1:00am
Terry Butcher fears he may miss out on two of his transfer targets.Motherwell boss Terry Butcher fears he may miss out on two of his transfer targets.
Butcher had targeted Craig Easton and Patrick McCourt as prospective new signings, but he is now resigned to neither player arriving at Fir Park.
Leyton Orient are thought to be close to signing former Livingston midfielder Easton, while McCourt may stay at Shamrock Rovers much to the disappointment of Butcher.
"Craig Easton looks as though he will sign for Leyton Orient and according to the papers McCourt is going to stay at Shamrock Rovers," bemoaned Butcher.
"I'd like to bring him here as he is an excellent player, but we'll see."


text:
They're among 15 "power players" signed up to play Jeopardy! in a special weeklong edition of the game that will be broadcast in May, it was announced Monday.
The game show will be in Washington to tape the segments early next month. Each contestant will be playing for charity — with the winner each day getting a $50,000 jackpot.
Other contestants include Ashleigh Banfield, Maria Bartiromo, Aaron Brown, Gretchen Carlson, Tucker Carlson, Kweisi Mfume, Peggy Noonan, Keith Olbermann and Christine Todd Whitman.


text:
PRESCOTT VALLEY – Alex Carrillo is taking a much easier way to the podium this time around.
The Desert Vista wrestler earned his second state medal on Friday by winning his first two matches at 113-pounds of the Division I state tournament at Tim's Toyota Center to make Saturday morning's semifinals.
While wrestling for Corona del Sol last season, Carrillo lost his first match of the state tournament before going on a four-match win streak to earn fourth place at 106.
"I knew I had to come out strong," he said. "Last year, I had to battle and wrestle so matches just to have a chance."
While he is guaranteed a place, Carrillo is far from done. He has reached a new level in recent weeks by just letting the nerves go. He is wrestling free and easy.
It's led to some impressive wins this postseason and it is going to take another when he wrestles Mesa Mountain View's Paden Mason (41-4) in Saturday's semifinals.
Mason beat Carrillo (30-7) at Flowing Wells last season and again this year when the match was stopped due to a possible concussion for the latter.
"I'm a different wrestler," Carrillo said. "I've been wrestling live with my brother (Timmy, a former DV state placer) and if I can score on him I can score on anyone. I am lot more confident."
The Thunder's other state semifinalist is senior Tristan Ezell, who has opened up his takedown repertoire in recent weeks to go along with his patented upper body throws.
"I've never been a No. 1 seed and I've had to battle my way through," said Ezell, who finished fifth last year at 195. "I have to work that much harder. It's OK. I got one more before I can go for gold."
Ezell (32-6) takes on top-seeded Bradley Burston (44-1) in the semifinals.
"Tristan knows it's now or never as a senior," Thunder coach David Gonzalez said. "He's opened up his offense and he's doing things he's always been capable of on his feet but was hesitant."
The Thunder's four other competitors had a rough go of it as only junior Jeremiah Imonode (182) is alive after going 2-1 on the day. He lost 7-0 in the quarterfinals to former state runner-up Derek Andresen of Hamilton.
Imonode, a three-time state qualifier looking to place for the first time, then beat Dobson's Santiago Fierros 15-10. Imonode (35-10) has to win his first consolation match on Saturday morning to place as he faces Sandra Day O'Connor's Chris Davis (42-11).
Freshman Chad Porter (160) and senior heavyweight Adam Ortega (HVY) lost both of their matches, while freshman Gage McGrew (106) failed to make weight.
"Freshmen," Gonzales said disgustedly.
Contact writer: (480) 898-7915 or email@example.com. Follow him on Twitter @JSkodaAFN.


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My family of 4 stayed here for one night on our way to Port Canaveral. The price was great and our room was clean. We checked in pretty late and the desk clerk was just as nice if it were 9am. The only problem was the in-room fridge was not cold enough and it took forever for the microwave to heat the food. That was fine b/c thats what fast food places down the road was for. :-) The location right off I-95 was perfect and the area was very nice and I felt safe there at night. If we're ever have to pass through Palm Coast again, we would definitely stay.
- Reservation Options:
- TripAdvisor is proud to partner with Booking.com, Priceline, Expedia, Hotels.com, Orbitz, Ctrip TA, TripOnline SA, Cancelon, Hotwire, Travelocity, getaroom.com, HotelsforEveryone and HotelQuickly so you can book your Microtel Inn & Suites by Wyndham Palm Coast reservations with confidence. We help millions of travelers each month to find the perfect hotel for both vacation and business trips, always with the best discounts and special offers.
- Also Known As:
- Microtel Inn And Suites Palm Coast
- Microtel Inn & Suites Palm Coast Hotel Palm Coast
- Microtel Palm Coast
- Microtel Hotel Palm Coast
- Palm Coast Microtel


text:
|900 sq. ft.
|Property type
|Minimum Stay
|2 nights
Gorgeous, wide-open views from this unique house in Wonder Valley. The best of both worlds: In the middle of nowhere, but only 15 minutes to Joshua Tree National Park and Twentynine Palms. Indoors, you'll delight in the beautiful, colorful tile work by local artist Perry Hoffman, along with wide windows that invite the desert inside. Shaded front porch.
State-of-the-art AC/heating unit. Wood-burning furnace . WiFi included.
Lovely, peaceful walks from the house. Starry nights are stunning. On moonlit nights, you can practically read outside. Bird lizards, rabbits, coyotes, cloudbursts, wind, quiet.
We love this house. We love the desert. We are happy to open it to like-minded guests who will respect the space and the landscape, who long for some peace and quiet. If that's you, you are most welcome! We have a two-guest limit, with some exceptions.
Please note that while there's running hot water for shower and kitchen, you will need to bring your own drinking water. If you want a fire, please bring your own wood.
Please...it's very important that all doors and windows are securely closed before you leave. During your stay, feel free to open screened doors and windows, but make sure those are shut tightly when you check out. Wind and desert life love to enter the place and explore!
No smoking indoors. Mellow dogs okay but not on furniture or bed. If you have a dog, please note that there's no fence around property.
I live in Meiners Oaks, CA, with my wife and children. I teach writing and literature at Ventura College.
Gabriel Arquilevich purchased this house in 2012
I have always loved the desert, and always dreamed of a little place surrounded by silence and sand. I rented this house four years ago and kept coming back until it became clear that it's time. My wife came to love the place as well, and so it's our 'baby'.
The feel of the open skies, the beauty and play of the interior of the house, the proximity to Joshua Tree--all this and more drew us here. We love that there's no fence--just desert around.
This was just what we were looking for- a quiet getaway in a small house surrounded by beautiful desert landscape. Very convenient for visiting Joshua Tree National Park. The house was very unique and well taken care of.
Gabriel was a terrific host and the place was exactly as described. Cute and kooky in the best of ways. Want to get away from it all? This spot in Wonder Valley will certainly do the trick.
If you're looking to get away, this is the place. This house is adorable and clean and the bathroom is amazing! The house is far enough out to feel isolated while still being close to modern conveniences. Joshua Tree National Park is right there! We hiked all day during the day and sat under the stars at night. It was relaxing, refreshing and just what we needed!
This was the ideal homestead for our stay! It was clean, the owners were fabulous in terms of communicating with us, and it is conveniently located -minutes drive from Joshua Tree National Park and probably no more than 20 minutes to the nearest grocery store. The location it is in is gorgeous. It is in the desert but is surrounded by gorgeous mountains that make for beautiful sunsets. The interior is really unique (especially the shower) and the outside is very welcoming for those who would just like to sit and enjoy the views or silence of the desert. We were able to get groceries and prepare the majority of our meals in the kitchen which was both a money-saver and nice after days spent in the park. We definitely recommend this rental, especially for the price. I shopped around and other accommodations had at least a couple sketchy reviews AND were more expensive. This was a cozier and more personal space. No regrets!
A lovely getaway in the middle of the Twentynine Palms desert. Highly recommended as a place to recharge and take in the natural beauty of the Joshua Tree area.
I just spent a very relaxing week in Wonderland. Everything about the house and location was exactly as described in VRBO - it's minutes from town and the park's 29 Palms entrance, but seems worlds a way from everything. The house is well cared for, comfortable, clean, and has all of the necessities. It was a great launching pad for my explorations of the park, and even a day trip to Death Valley.
Gabriel was excellent for communication during the process to book when I had questions about the property and pets, and continued that before, during and after my stay. Many thanks and I hope to return soon.
Check out the Glass Outhouse Gallery! Five minute drive. Amboy Crater is 35 minutes away--wonderful drive and incredible, surreal hike to top of crater. A simple walk up the road across Godwin and you have lovely 360 degree views.
|Rate Period
|Weekend Night
My Standard Rate
2 night minimum stay
|cleaning fee
|Pet Fee
|Refundable damage deposit
We ask that guests sign a waiver of liability. Upon confirmation of reservation we'll email to you. You can sign and scan back to mail back before your visit.
50% refund if canceled at least 30 days before arrival date.
100% refund if canceled at least 60 days before arrival date.


text:
A good carpet ties a room together by complementing the décor and mediating domestic disputes between the walls. Pamper the hardworking peacemaker with this Groupon.
Choose from Three Options
- $70 for a three-room carpet cleaning, up to a total of 400 square feet (a $140 value)
- $105 for a five-room carpet cleaning, up to a total of 800 square feet (a $213 value)
- $89 for upholstery cleaning for a sofa and a love seat or a sofa and a chair (up to a $179.95 value)<p>
Stevens Chem-Dry's experienced technicians cleanse carpeting and upholstery with a pet- and kid-safe quick-drying solution. Equipped with a PowerHead machine, the techs blast carpets with carbonated cleaner called The Natural, a bubbly elixir that penetrates textile forests to oust entrenched dirt and stains. The hot-extraction system then inhales the nontoxic solution, sucking away the water to let carpets dry within one to two hours, unlike traditional steam cleaning, which leaves carpets soggy and feverishly crazed for days. Couches, love seats, and chairs can also benefit from one-hour upholstery cleaning, which douses seats in the same effervescent technology.


text:
FREE Shipping on Orders Over $50
Time to Wear White Top
This product is unavailable
It's time to bring white back in your wardrobe. This super comfy top is lightweight and gorgeous for Spring, Fall, and Winter. The lace trim on the bottom adds the perfect texture contrast. You'll wear this ALL THE TIME, trust us.
Material: 97% rayon, 3% spandex
23" to 31" long (middle of the bottom to its ends)


text:
Doctor insights on:
What Is The Bodysuit That Make You Lose Weight
Could weed make you lose weight ?
Cannabis is not: A weight loss agent. Some people actually develop hunger after use of cannabis. ...Read more
Lose Weight (Definition)
Many people resolve to lose weight in the New Year for different reasons. For those who are overweight or obese, there are many health benefits to losing weight. It can help decrease your chances of developing diseases including diabetes, heart disease, high blood pressure, osteoarthritis, and even certain types of cancer. Low-calorie diets combined with increased physical activity are thought to be most effective long term. The healthiest weight loss regimen, therefore, is one that consists of making lifestyle changes that incorporate a balanced diet ...Read more
Does clamato make you lose weight?
No it does not: Cause weight loss. But tomato juices are low in calories. ...Read more
Can eating raw foods make you lose weight?
No: No it does not.Get a more detailed answer ›
Can eating baby powder make you lose weight?
No: Never, ever eat baby powder!Get a more detailed answer ›
Which types of foods make you lose weight faster?
Unprocessed foods: One of the keys to losing weight and keeping it off is to do it in a thoughtful and meaningful way. This includes having the right perspective on food, exercise, sleep, and stress. For food, eat mostly a plant based diet with lots of vegetables, fruits, nuts, beans, seeds, and whole graims and for protein eat wild fish like salmon every other day. Avoid processed foods. Exercise up to 45 minutes. ...Read more
Are there any pills that make you lose weight fast?
Weight loss meds: I can't personally make recommendations for weight loss products but the following are FDA approved: Alli, Xenical (orlistat),Meridia (sibutramine), Adipex-P (phentermine) and Sanorex (mazindol). ...Read more
What are some pills that make you lose weight fast?
Weight loss: The following are FDA approved: Alli, Xenical (orlistat),Meridia (sibutramine), Adipex-P (phentermine) and Sanorex (mazindol). However, I recommend exercise and food control with healthy diet if you want to lose weight. ...Read more
How to know what exercises actually make you lose weight?
Cardio Mix: The best way to lose weight is cardio and a balanced diet. However, do not always do the same exercise or you will increase your risks for stress injuries. Mix things up with running, biking, swimming, or circuit training. Ultimately you need to burn more than you consume. Exercises such as crunches, planks, sit-ups, etc are good for toning the abdominal muscles, but cardio is best for weight loss. ...Read more
Will eating the same foods every day make you lose weight?
It depends: It depends what foods you eat. If they are carbohydrates, absolutely not. If they are veggies, fish, poultry, nuts then it can. ...Read more
Would eating only one bar of chocolate per day make you lose weight?
Probably: If that is all you ate each day, and the chocolate bar was not too big, you would lose weight. But this is a rather odd way to do that and does not supply other vitamins, minerals and dietary needs for general health. ...Read more
- Talk to a doctor live online for free
- What exercises make you lose weight?
- What drink can make you lose weight?
- What can make you lose weight fast?
- Ask a doctor a question free online
- What makes you not lose weight while on the hcg diet?
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- Talk to a preventive medicine specialist online for free


text: It's all about the hair. Okay, maybe not all of it. Whether you're the bride or a bridesmaid, you're bound to be browsing thousands of beautiful hairstyles from this day on. From a romantic loose bun to a messy braid, we've highlighted some stunning looks that, in our opinion, are worth saving, pinning, and trying for your big day.Photo by: Elizabeth Messina on Kiss the Groom via Lover.lyStart


text:
A technology introduced in Vanilla
|Required techs
|Leads to
| Mass Media
Satellites (with Rocketry)
|Units enabled
| Submarine
|Buildings enabled
| Eiffel Tower
Rock 'n' Roll
"Then one fine mornin' she puts on a New York Station. You know her life was saved by Rock 'n' Roll."
-The Velvet Underground, "Rock and Roll"
Radio enables the powerful Bomber (with Flight) and Guided Missile (with Rocketry) units, plus the Attack Submarine (with Combustion) and Submarine units. It also allows you to build the Eiffel Tower, Cristo Redentor and Rock 'n' Roll wonders.
Civilopedia EntryEdit
Prior to Guglielmo Marconi's invention of the radio in 1896, long-distance communication was carried out either by mail or over miles of cable via telegraph. Marconi's first demonstration of the radiotelegraph transmitted a message just over one mile without the use of wires. Continued improvements increased transmission range to over 200 miles by early 1901, and by the end of the year a single letter ("A") had been transmitted across the Atlantic Ocean. By 1905, many ships were equipped with radiotelegraphs for ship-to-ship and ship-to-land communications, and by 1915 the invention of the three-element vacuum tube, or triode, made it possible to regularly transmit voice messages over the airwaves. Throughout the years, radio has been refined not only for communication, but for detection and ranging (Radar) and astronomy.


text:
All Morton Plant Mease Primary Care physician office hours are Monday through Friday 8am to 5pm; however some offices have expanded hours beginning at 7:30am and may remain open until 6pm. Please click on a specific location for their office hours.
Phone calls are answered by the office during regular office hours and are handled appropriately based on urgent and non-urgent needs. Patient calls for urgent medical advice during regular business hours are handled in an expedited manner by a clinical team member and/or the physician.
Patient calls after hours are addressed by the offices' answering service. The answering service conveys messages regarding patient care directly to the physician on call, and an MPMPC physician then returns the message to the patient via telephone within 30 minutes.
There are additional options for communication with your physician and physician's office, as well as seeking after-hours care. WebView Patient Portal is a web-based tool in which patients can request medication refills, request appointments and also ask basic questions to your primary care physician in a HIPAA-compliant, secure mode of communication. Ask your primary care physician's office about how to get set up for WebView.
Baycare Urgent Care Centers are a great alternative when your primary care provider is not available. Board certified physicians provide walk-in urgent care 7 days a week to patients of all ages. If follow-up is needed, they will coordinate your care with your regular primary care physician. There are several BayCare Urgent Care Centers trhoughout the Tampa Bay area. Click here to visit their website for more information.


text:
BS.Player 2.70
Hi there,
Today we're looking at BSPlayer, a really popular media appl that sits somewhere between Apple's iTunes and the basic but flexible VLC Player.
The interface is nice and small, and to build your library all you have to do is right click and go to media library, or just click the little ML button here.
You can't drag files into the library, instead using these add buttons we can import our media files.
To do it quickly, just hit add drive, and let BS Player search your Hard Drive for compatible music files. To make a playlist, click here, and choose your songs.
The biggest difference between BSPlayer and the competition is that you can change its appearance. Right –click, go to options and then Skins, and you can choose a new look for the player. There are a few included, and tons more available on the BSPlayer homepage. Just click the skin's name like this, and as you can see, it changes in real time. This way you can make sure your media player looks right at home in your personalised desktop.
- Views:
- 726217 |
- Likes:
- 44926
- Tags:
Articles BS.Player
The best video editing software: compare, download, and enjoy!
Discover the best editing tools to create every kind of video content - from home movies to high-end... See more
Best free video editing apps
Now that most people have a smartphone, it's possible to take photos and record video all the time.... See more
User reviews BS.Player
Was great
For many years I have used BS.Player and been very happy with it, it's lite and easy to use, but just recently it has stopped p... More
- User name
- User reviews
- 0
The only one that worked perfectly.
tried them all even VLC but they either stuttered the audio or the video... More
- User name
- debbie.dresser.77
- User reviews
- 1


text:
- westbound
- adjective Date: 1864 traveling or heading west
New Collegiate Dictionary. 2001.
New Collegiate Dictionary. 2001.
westbound — ☆ westbound [west′bound΄ ] adj. bound west; going westward … English World dictionary
westbound — [[t]we̱stbaʊnd[/t]] ADJ: ADJ n Westbound roads or vehicles lead to the west or are travelling towards the west. Traffic is slow on the westbound carriageway of the M4. ...the last westbound train to leave Chicago … English dictionary
westbound — 1. adverb Towards the west; in a westerly direction. He was driving westbound on the George Washington Bridge. 2. adjective Which is, or will be, moving towards the west. Westbound traffic was blocked for miles … Wiktionary
westbound — west|bound [ˈwestbaund] adj travelling or leading towards the west ▪ Westbound traffic is moving very slowly. ▪ an accident on the westbound carriageway of the motorway … Dictionary of contemporary English
westbound — west|bound [ west,baund ] adjective leading or traveling toward the west: westbound traffic the westbound lane of the highway … Usage of the words and phrases in modern English
westbound — UK [ˈwes(t)ˌbaʊnd] / US adjective leading or travelling towards the west westbound traffic the westbound lane of the motorway … English dictionary
westbound — adj. Westbound is used with these nouns: ↑track … Collocations dictionary
westbound — west ► NOUN (usu. the west) 1) the direction towards the point of the horizon where the sun sets at the equinoxes, on the left hand side of a person facing north. 2) the western part of a country, region, or town. 3) (the West) Europe and North… … English terms dictionary
westbound — /west bownd /, adj. proceeding or headed west. [1880 85, Amer.; WEST + BOUND2] * * * … Universalium
westbound — adj. moving in an westerly direction, headed toward the west … English contemporary dictionary


text:
Dose-finding Study of Hexaminolevulinate (HAL) Photodynamic Therapy (PDT) to Treat Cervical Neoplasia
This study has been completed.
Information provided by (Responsible Party):
ClinicalTrials.gov Identifier:
First received: December 7, 2010
Last updated: April 8, 2016
Last verified: April 2016
- Full Text View
- Tabular View
- Study Results
- Disclaimer
- How to Read a Study Record
An effective and safe medical therapy would be most welcome to reduce the need for surgical interventions and related adverse events and psychological impact on patients with cervical cancer precursors. In this clinical trial, the investigators propose to evaluate the efficacy and safety of photodynamic therapy (PDT) using hexaminolevulinate (HAL) for mild to moderate-grade CIN (grade 1-2).
|Cervical Intraepithelial Neoplasia
|Drug: HAL 5% with illumination Drug: HAL 1% with illumination Drug: HAL 0.2% with illumination Drug: Placebo ointment without illumination
|Phase 2
|Study Type:
|Study Design:
|Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double Blind (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary Purpose: Treatment
|Official Title:
|A Randomized Phase II Dose-finding Study of Hexaminolevulinate (HAL) Photodynamic Therapy (PDT) in Patients With Low/Moderate-grade Cervical Intraepithelial Neoplasia (CIN1 or 2)
Resource links provided by NLM:
Drug Information available for: HexaminolevulinateU.S. FDA Resources
Further study details as provided by Photocure:
Primary Outcome Measures:
- Comparison of Lesion Response Rates of Three Different Doses of HAL PDT and Placebo at 3 Months After Treatment. [ Time Frame: 3 months after last treatment ]Lesion response was defined by three variables: Histology, cytology and HPV. Patient response at three months required histology regression to CIN1 or normal, cytology of LSIL or less severe, and HPV negative.
Secondary Outcome Measures:
- Comparison of HPV Response of Three Different Doses of HAL PDT and Placebo at 3 Months After Treatment. [ Time Frame: 3 months after treatment ]HPV response was defined as clearance of baseline HPV infection, asssessed by genotype
|Study Start Date:
|April 2011
|Study Completion Date:
|December 2012
|Primary Completion Date:
|September 2012 (Final data collection date for primary outcome measure)
|Assigned Interventions
Experimental: HAL 5% with illumination
Drug: HAL 5% with illumination
Treatment with a singe dose of 2g, HAL 5% ointment followed by photoactivation
Experimental: HAL 1% with illumination
Drug: HAL 1% with illumination
Treatment with a singe dose of 2g, HAL 1% ointment followed by photoactivation
Experimental: HAL 0.2% with illumination
Drug: HAL 0.2% with illumination
Treatment with a singe dose of 2g, HAL 0.2% ointment followed by photoactivation
Placebo Comparator: Placebo ointment without illumination
Placebo without illumination
Drug: Placebo ointment without illumination
Treatment with a singe dose of 2g placebo ointment, no photoactivation
|Ages Eligible for Study:
|18 Years and older (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Patients with ectocervical CIN1 or CIN2 as verified by local pathology (biopsy) obtained within the last month
Satisfactory colposcopy examination including:
- visibility of entire transformation zone including the squamocolumnar junction and
- visibility of entire lesion margin
- Negative endocervical os by colposcopy
- Colposcopical visible lesion at visit 2, before treatment
- Patients with an average sized uterine cervix (approximately 27mm diameter) suitable for application of the Klemcap
- Age 18 or above
- Written informed consent signed
Exclusion Criteria:
- Previous treatment of CIN or invasive disease
- Lesion(s) extending to the vaginal vault
- Atypical glandular cells (AGC) or adenocarcinoma in situ (AIS) on cytology, malignant cells on cytology or histology or other suspicion of either micro-invasive or invasive disease
- Suspicion of endocervical disease on colposcopy
- Current severe pelvic inflammatory disease, severe cervicitis, or other severe gynaecological infection as per colposcopy and clinical examination
- Undiagnosed vaginal bleeding
- History of toxic shock syndrome
- Known or suspected porphyria
- Known allergy to hexaminolevulinate or similar compounds (e.g. methyl aminolevulinate or aminolevulinic acid)
- Pregnancy, or intention to become pregnant during the study period
- Nursing
- Childbirth or miscarriage within six weeks of enrolment
- Use of heart pacemaker
- Participation in other clinical studies either concurrently or within the last 30 days
- Risk of poor protocol compliance. Patient participation should be considered with respect to living far away from the hospital, plans for moving to another city/state, frequent travelling, planning to become pregnant, drug abuse/alcoholic, difficult working hours, family obligations, other illness (e.g. psychiatric), etc.
- Unwillingness to use adequate birth control (not abstinence) from screening until last PDT
- Patient is the investigator or any sub-investigator, research assistant, pharmacist, study coordinator, other staff or relative thereof directly involved in the conduct of the protocol
Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01256424
Please refer to this study by its ClinicalTrials.gov identifier: NCT01256424
|University Hospital Hannover
|Hannover, Germany
|Haukeland University Hospital
|Bergen, Norway, 5021
Sponsors and Collaborators
|Principal Investigator:
|Peter Hillemanns, MD, PhD
|University Hospital Hannover
More Information
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Keywords provided by Photocure:
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on July 21, 2017
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
|Responsible Party:
|ClinicalTrials.gov Identifier:
|NCT01256424 History of Changes
|Other Study ID Numbers:
|Study First Received:
|December 7, 2010
|Results First Received:
|August 6, 2014
|Last Updated:
|April 8, 2016
Keywords provided by Photocure:
Additional relevant MeSH terms:
Carcinoma in Situ
Cervical Intraepithelial Neoplasia
Neoplasms, Glandular and Epithelial
Neoplasms by Histologic Type
ClinicalTrials.gov processed this record on July 21, 2017


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Most people know how to enter keywords into Google to gather information they need. But if you're looking to take that skill a step further, consider a career as an online researcher. Depending on the industry you work in, you could put your research skills to work -- and many jobs let you work at home. Here are tips on how to be an online researcher.
Things You'll Need
- Computer with Internet
- Pen
- Paper
- Resume / Cover Letter
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Learn about the online research field. There are many instances where conducting online research can be useful. For writers, it can be necessary to gather facts or learn about a new field and then apply it into writing. There are also people paid strictly to research online. But because this is typically a work-at-home field, you must be leery about the sources you use to find jobs. Additionally, you must possess advanced research skills and know more than how to type keywords into a search engine to be a solid researcher.
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Let us know when your receive great advice so we can thank our lawyers and point others with similar questions in the right direction.Got it!
Upon posting bail, conditions are you appear before the court on a given day to enter a plea. Sentencing, of any sort, prior to entering a plea denies due process. Your thoughts on a DUI with a B.A.L. of 0.04.
You are not being sentenced at your next court date. That is simply an arraignment where a copy of the criminal complaint will be given to you or your lawyer. At that point, you decide whether to take a deal and set a trial. If you plead guilty to DUI or something less, or you go to trial and then lose, you will be sentenced, and not before. Sentencing is a long way down the road, and there must be a finding of guilt before that.
There are a ton of things that can go wrong in DUI. Hire private counsel. My office offers free consultations.Ask a similar question
The phrasing of your question is confusing. If by alternative sentencing, you mean a deferred sentencing or stay adjudication, is a negotiation which does not require you to be adjudicated at all so long as you complete conditions and then the case is dismissed.
The information presented here is for informational purposes only and does not constitute legal advice. The Goodman Law Group, P.C. recommends that you consult an attorney with experience in your specific legal issue. Please contact us to schedule a confidential discussion of your situation. Such communication does not create an attorney-client relationship of any kind until a formal engagement agreement is signed by both you and the Goodman Law Group, P.C.Ask a similar question
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Law Offices of J Thomas Smith J.D., Ph.D 11500 Northwest Freeway, Suite 280 Houston, TX 77092 713-LAWYER-2 www.MyImmigrationLawyer.info NOTE: Responses are for the education of the community at large and is not intended to be "legal advice." No attorney-client relationship is established by responses or comments.Ask a similar question
Your question is a bit confusing but I think you are asking about bail conditions prior to entering a plea. The court can set certain conditions if you are to be released. For a DUI, some judges put conditions such as not drinking until next court or not picking up new DUI cases. Not ever court puts conditions but they are usually done in conjunction with an OR release or bail release. Regarding your DUI, I suggest you set up appointment for free consult to carefully review the circumstances. Good luck.
The answer above is only based upon the limited information provided. The answer is limited and my review is likewise limited, and thus the response is not intended to be acted upon as legal advice. Although licensed in numerous states, I am currently only licensed to practice law in the state of Nevada. No attorney-client relationship is formed until you sign an attorney-client agreement with my office. Any information provided is for discussion purposes only and there is no attorney-client relationship formed. Only general legal information is provided. Each case is unique and accurate legal advise would require review of all details and documents for each specific case. It is possible that the comments here, while meant to be helpful, may in some cases not be complete or accurate.Ask a similar question
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|Additional Physical Format:
|Online version:
Drucker, Peter F. (Peter Ferdinand), 1909-2005.
Post-capitalist society.
New York, NY : HarperBusiness, ©1993
|Material Type:
|Internet resource
|Document Type:
|Book, Internet Resource
|All Authors / Contributors:
Peter F Drucker
|0887306209 9780887306204
|OCLC Number:
|232 pages ; 25 cm
|The transformation --
pt. 1. Society. From capitalism to knowledge society --
The society of organizations --
Labor, capital, and their future --
The productivity of the new work forces --
The responsibility-based organization --
pt. 2. Polity. From nation-state to megastate --
Transnationalism, regionalism, and tribalism --
The needed government turnaround --
Citizenship through the social sector --
pt. 3. Knowledge. Knowledge: its economics and its productivity --
The accountable school --
The educated person.
|Peter F. Drucker.
A probing and incisive analysis of the major world transformation from the Age of Capitalism to the Knowledge Society and how it will affect society, economics, business, and politics now and in the years ahead. In Post-Capitalist Society Peter Drucker describes how every few hundred years a sharp transformation has taken place and greatly affected society - its worldview, its basic values, its business and economics, and its social and political structure. According to Drucker, we are right in the middle of another time of radical change, from the Age of Capitalism and the Nation-State to a Knowledge Society and a Society of Organizations. The primary resource in the post-capitalist society will be knowledge and the leading social groups will be "knowledge workers." Looking backward and forward, Drucker discusses the Industrial Revolution, the Productivity Revolution, the Management Revolution, and the governance of corporations. He explains the new functions of organizations, the economics of knowledge, and productivity as a social and economic priority. He covers the transformation from Nation-State to Megastate, the new pluralism of political systems, and the needed government turnaround. Finally, Drucker details the knowledge issues and the role and use of knowledge in post-capitalist society. Divided into three parts - Society, Polity, and Knowledge - Post-Capitalist Society provides a searching look into the future as well as a vital analysis of the past, focusing on the challenges of the present transition period and how, if we can understand and respond to them, we can create a new future.
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Related Subjects:(23)
- Economic history -- 1990-
- Capitalism.
- World politics -- 1989-
- Information society.
- Histoire économique -- 1990-
- Capitalisme.
- Politique mondiale -- 1989-
- Société informatisée.
- Société postindustrielle.
- Economic history.
- World politics.
- Kapitalisme.
- Economische verandering.
- Informatiemaatschappij.
- Wirtschaftssystem.
- Wirtschaftsentwicklung.
- Nachindustrielle Gesellschaft.
- Sozialer Wandel.
- Wirtschaftspolitik.
- Capitalism
- Information society
- Histoire économique - 1990-
- Politique mondiale - 1989-
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