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Just Plane Simple
This lesson introduces students to three of the six simple machines used by many engineers. These machines include the inclined plane, the wedge and the screw. In general, engineers use the inclined plane to lift heavy loads, the wedge to cut materials apart, and the screw to convert rotational motion into linear movement. Furthermore, the mechanical advantage describes how easily each machine can do work and is determined by its physical dimensions.
Copycat Engineers
This lesson introduces students to the idea of biomimicry — or looking to nature for engineering ideas. Biomimicry involves solving human problems by mimicking natural solutions, and it works well because the solutions exist naturally. There are numerous examples of useful applications of biomimicry, and in this lesson we look at a few fun examples.
Light vs. Heat Bulbs
Students measure the light output and temperature (as a measure of heat output) for three types of light bulbs to identify why some light bulbs are more efficient (more light with less energy) than others.
We've Come a Long Way, Baby!
Students discuss several human reproductive technologies available today — pregnancy ultrasound, amniocentesis, in-vitro fertilization and labor anesthetics. They learn how each technology works, and that these are ways engineers have worked to improve the health of expecting mothers and babies.
Students learn the connections between the science of sound waves and engineering design for sound environments. Through three lessons, students come to better understand sound waves, including how they change with distance, travel through different mediums, and are enhanced or mitigated in designed sound environments. Students are introduced to audio engineers who use their expert scientific knowledge to manipulate sound for the production of music and film. They learn how the invention of the
Riding the Radio Waves
Through this lesson students learn how AM radios work through basic concepts about waves and magnetic fields. Waves are first introduced by establishing the difference between transverse and longitudinal waves, as well as identifying the amplitude and frequency of a given waveform. Students then learn general concepts about magnetic fields, leading into how radio waves are created and transmitted. Several demonstrations can be performed in order to help students better understand these concepts.
Drifting Continents
This activity is a teacher-led demonstration of continental drift and includes a math worksheet for students involving the calculation of continental drift over time. Students will understand what continental drift is, why it occurs, and how earthquakes occur because of it.
Build it Better!
Students use their knowledge of tornadoes and damage. The students will work in groups to design a structure that will withstand and protect people from tornadoes. Each group will create a poster with the name of their engineering firm and a picture of their structure. Finally, each group will present their posters to the class.
Stack It Up!
Students analyze and begin to design a pyramid. Working in engineering teams, they perform calculations to determine the area of the pyramid base, stone block volumes, and the number of blocks required for their pyramid base. They make a scaled drawing of the pyramid using graph paper.
Bombs Away!
Students will design and build a device to protect and accurately deliver a dropped egg. The device and its contents represent a care package that must be safely delivered to people in a disaster area with no road access. In a similar fashion to a team of design engineers, students will design their devices using a number of design constraints including limited supplies. The activity emphasizes the change from potential energy to kinetic energy of the device and its contents and the energy trans
Water, Water Everywhere
Students learn about floods, discovering that different types of floods occur from different water sources, but primarily from heavy rainfall. While floods occur naturally and have benefits such as creating fertile farmland, students learn that with the increase in human population in flood-prone areas, floods are become increasingly problematic. Both natural and manmade factors contribute to floods. Students learn what makes floods dangerous and what engineers design to predict, control and sur
Marine animal tracking
The following lesson is an introduction to the ideas and implications of animal tracking. Animal tracking is a useful method used within science and commercial industries. For instance, when planning the development coastal areas, animal presence and movement should be taken into consideration. The lesson engages students in an activity to monitor animal foraging behavior on a spatial scale. The students will break into groups and track each other's movements as they move through a pre-determi
Ohm's Law I
Students will work to increase the intensity of a light bulb by testing batteries in series and parallel circuits. It analyzes Ohm's Law, power, parallel and series circuits, and ways to measure voltage and current.
Conduction, Convection, and Radiation
With the help of simple, teacher-led demonstration activities, students learn the basic concepts of heat transfer by means of conduction, convection, and radiation. Students then apply these concepts as they work in teams to solve two problems. One problem requires that they maintain the warm temperature of one soda can filled with water at approximately body temperature, and the other problem is to cause an identical soda can of warm water to cool as much as possible during the same thirty-minu
Heredity Mix 'n Match
Students randomly select jelly beans (or other candy) that represent genes for several human traits such as tongue-rolling ability and eye color. Then, working in pairs (preferably of mixed gender), students randomly choose new pairs of jelly beans from those corresponding to their own genotypes. The new pairs are placed on toothpicks to represent the chromosomes of the couple's offspring. Finally, students compare genotypes and phenotypes of parents and offspring for all the "couples" in
Asteroid Impact
Asteroid Impact is an 8-10 class long (350-450 min) earth science curricular unit where student teams are posed with the scenario that an asteroid will impact earth. They must design the location and size of underground caverns to save the people from uninhabitable earth for one year. Driven by this adventure scenario, student teams (1) explore general and geological maps, (2) determine the area of their classroom to help determine the cavern size required, (3) learn about map scales, (4) test r
Testing the Caverns - Optional
This activity provides a fun, activity-based closure to the Asteroid Impact unit. Students build model caverns using paper mache or clay and bury them in a tray of sand. Next, they test the models by dropping balls onto them to simulate an asteroid hitting the earth. By molding paper mache around a balloon to form a dome, or around a small cardboard box to form a rectangular structure, students will be able to build their caverns.
Smakers, jongeren en cultuur 2010 : Lees- en kijkboek Gratis online boek, uitgegeven door CJP en de afdeling Jeugd over jongeren (15 tot 25-jarigen). Je vindt zowel resultaten van Europese en andere onderzoeken als reportages over uiteenlopende onderwerpen: …
Gratis online boek, uitgegeven door CJP en de afdeling Jeugd over jongeren (15 tot 25-jarigen).
Je vindt zowel resultaten van Europese en andere onderzoeken als reportages over uiteenlopende onderwerpen: …
Leerkrachten nemen leerlingen creatief beet Op de jaarlijkse "fop-dag" hebben heel wat leerkrachten creatieve manieren om de leerlingen beet te nemen. Volgens de traditie van één april, vertellen ze de leerlingen een verhaaltje dat nog nét geloofwaardig is. KlasCement, het lerarenportaal …
Op de jaarlijkse "fop-dag" hebben heel wat leerkrachten creatieve manieren om de leerlingen beet te nemen. Volgens de traditie van één april, vertellen ze de leerlingen een verhaaltje dat nog nét geloofwaardig is. KlasCement, het lerarenportaal …
Organització i gestió de centres d'educació infantil i d'educació primària
L'assignatura pertany a la formació de la diplomatura de Mestre d'Educació Infantil i Primària. Es centra en l'estudi de les funcions que corresponen al mestre d'Educació Infantil i Primària, en la visió pedagògica sobre els processos i pràctiques d'innovació didàctica que s'han de dur a terme en l'Educació Infantil i Primària, tant en contextos escolars com en els extraescolars, així com en el coneixement de l'organització i gestió d'una escola intercultural i i


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This season Orla heads back to the University Library. Inspired by Ali MacGraw in the film Love Story, the collection combines late 60's preppy with an early 70's romantic look. Maths and geometry are the main inspirations for the pattern and print. Geometric shapes make up the Ballroom Dancing prints and graph paper checks are seen in varying sizes to create a bold aesthetic. Orla's initials are used geometrically for the 'OK' print which features on clothing and accessories. Key items such as the belted wool trench coat and flowing maxi dresses give that seventies feeling with boxier style jackets and skirts in mohair fabrics. Leather accessories are worked into extreme scales from supersized frame bag in a giant printed grid check to the cute mini box backpack with signature all over punching. It may all be quiet in the library, but this bold bright collection is anything but that. StyleCard holders save 10% on the AW15 collection online and in the Covent Garden and Kings Road stores from September 1st to November 22nd. This is better than OK.
Orla Kiely (Covent Garden), 31 Monmouth Street, London. WC2H 9DD
020 7240 4022
Orla Kiely (Kings Road), 207 Kings Road, London. SW3 5ED
020 7351 2644
Instagram: @orlakiely
Twitter: @orlakiely
To see the StyleCard offer click here

subset: commoncrawl


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Related terms for "measure returned activated sludge ":
activated sludge companies
, returned activated sludge companies
ABB is a leader in power and automation technologies that enable utility and industry customers to improve performance while lowering environmental impact. The ABB Group of companies operates in around 100 countries and employs about 130,000 people. The company`s North American operations, headquartered in Cary, North Carolina, employ about 20,000 people in multiple ...
based in Zurich, SWITZERLAND.
Suppliers of instrumentation to the municipal and industrial sectors of the water and waster water market. Products include monitors for Colour, Aluminium, Phosphate, Iron, Oil in Water, TSS, DO, pH, Chlorine, BOD, COD, Multi-parameter monitoring, Sludge Blanket, cManufacturer of chemical reagents, forensic kits and industrial cleaning products for the leisure industry ...
based in Huddersfield, UNITED KINGDOM.
Since 1967, Markland Specialty Engineering has been designing and manufacturing process monitoring and control instrumentation that is valued by operators, managers and consultants, in diverse sectors, around the globe. Municipal water & wastewater treatment to measure primary, secondary, return-activated, and backwash sludge. Industrial processing and water & wastewater ...
based in Georgetown, ONTARIO (CANADA).
Pulsar® Process Measurement manufactures and supplies level, open channel flow and pump instrumentation. Our strength is in ultrasonic level measurement. This is a non-contacting technology that is used in a wide variety of industries and applications worldwide. Pulsar Process Measurement has been in existence since 1997, rising in a relatively short time to become one ...
based in Worcestershire, UNITED KINGDOM.
Pressure, Level, & Flow Products. Water/Wastewater Measurement & Analysis. SCADA products
based in Dana Point, CALIFORNIA (USA).
SenseAlyze Process Measurements is committed to your operation's needs, bringing 30 years of experience in the Northwest in process instrumentation, industrial wireless communications and motion control. Time is money, thank you for your time.
based in Bothell, WASHINGTON (USA).
Hanley Measurement & Control was established in 1981 to provide Instrumentation and Control Equipment for Process & Manufacturing Industries and Public Utilities. Hanley Measurement & Control offer a comprehensive range of measurement and control devices which utilise the latest technology advancements to ensure quality, reliability, accuracy and cost effectiveness. ...
based in Swords, IRELAND.
We are a creative team of engineers, designers, technicians, and strategic thinkers who are passionate about water. We are determined to conceptualize, design, and deliver solutions that fit your unique needs.Aeration Industries International has the expertise and aeration equipment to provide a full range of wastewater treatment solutions to optimize municipal and ...
based in Chaska, MINNESOTA (USA).
I.T.M.S CO' representing the most professional international manufacturers providing a wide range of Measuring, Control, Mechanical & Electrical Equipments & Instruments.
based in Octoper City, EGYPT.
Process Wastewater Technologies LLC is a leading global manufacturer of products for biological treatment, CSO/SSO, biosolids/sludge handling and municipal wastewater. We revolutionized the storm water and CSO treatment industry in the early 1990s by introducing continuous deflective separation technology to the market. We offer technologies for gross solids and sediment ...
based in Rosedale, NORTH CAROLINA (USA).
A supplier of state-of-the-art control/expert systems for an activated sludge process and thickening systems. Activated sludge award winning control technology solves foam and settling problems, improves thickening and reduce operational cost and carbon footprint by stabilizing activated sludge biomass and load on thickeners, controlling D.O. and sludge blanket depth.
based in Fremont, CALIFORNIA (USA).
Innovative Hydraulics distributes its Visual Hydraulics and Visual Water Designer water and wastewater modeling software. Visual Hydraulics wastewater software provides for the advanced analysis of treatment plant hydraulics, including full hydraulic profiles or individual units. Account for return flow scenarios and taking units off-line. The software includes many ...
based in Pittsburgh, PENNSYLVANIA (USA).
Analytik Jena is a leading provider of high-end analytical measuring technology, instruments, and products in the fields of biotechnology and molecular diagnostics and high quality liquid handling and automation technologies.
based in Jena, GERMANY.
VTS projects and builds ready to use sewage sludge systems for municipal and industrial operators. Special solutions exactly according to demand, technically and economically the best solution! Customer-specific sludge carrier systems, sludge grinding, sludge drainage, sludge carrier silos etc. with more than 30 years of experience. We move sewage sludge!
based in Neu-Anspach, GERMANY.
Spire Metering Technology offers one of the broadest, most affordable lines of flow measurement and energy metering products in the industry today. Through continuous innovation, we transform complex cutting-edge technologies into affordable, reliable solutions for accurate flow and energy measurement.
based in Marlborough, MASSACHUSETTS (USA).
Casella prides itself on providing precision instrumentation since 1799, supplying eminent figures including David Livingstone and Charles Darwin with instrumentation for their exploration and scientific work. As you would imagine, Casella has changed significantly over these 200 plus years but remains perfectly placed to offer reliable, trust worthy and credible ...
based in Kempston, UNITED KINGDOM.
Our traditional markets are the basic food and animal feed technology, the sugar industry, the food and nutrient industry, and the chemical industry. KAHL is one of the leading manufacturers of plants for conditioning biomass, wood, straw, waste tyres, sewage sludge, plastics scrap as well as domestic and industrial waste. More than 130 years of experience in plant and ...
based in Reinbek, GERMANY.
BioWater Technology is a company focusing on development of sales of innovative technologies and solutions for biological treatment of water and wastewater. Products include but are not limited to: MBBR, IFAS and Package Plants. We have offices in the United States and Norway and partners and representatives around the world. We provide Combined Fixed-Film Activated ...
based in Cumberland, RHODE ISLAND (USA).
Solar sludge drying. The Wendewolf moves and aerates up to 250 m³/h of sludge! The automatic programme ensures a continuous flow of the freshly pressed sludge through the drying bed. The required energy consists of electricity only, between 10 kWh to 30 kWh per ton of water evaporated. Industrial dryers require between 800 and 1000 kWh in thermal energy and electricity. ...
based in Kandern, GERMANY.
Matelco develops its activity in four main groups1. Water analysis1.1 Physical-chemical parameters in drinking, residual, pure and ultrapure water. 1.2 Organic parameters: COT, COD, TN, and E. Coli1.3 Special applications: metals, Sulfides, Cyanides, Hydrocarbons in water, analysis control Chorine-Soda, Viscosity... 2. Gas analysisApplications in inmission, ...
based in Cornellà de Llobregat, SPAIN.
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snowstorm hits Tokyo
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text: Neverland Ranch is the fruit of Michael Jackson's labor as a child. He made this place to make up for his lost childhood, and yet many people think it is strange. Well, I think Hitler fans are strange too, so we are even. This place has EVERYTHING a child would want, and the ungratefull little brats go and say they have been molested! Michael Jackson will be the world leader one day, so those little kids better watch out for lying on him!


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What is JotForm?
JotForm is a free online form builder which helps you create online forms without writing a single line of code. No sign-up required.
At JotForm, we want to make sure that you're getting the online form builder help that you need. Our friendly customer support team is available 24/7.
We believe that if one user has a question, there could be more users who may have the same question. This is why many of our support forum threads are public and available to be searched and viewed. If you'd like help immediately, feel free to search for a similar question, or submit your question or concern.
My forms are not workingAsked by greesondek on July 06, 2016 at 06:07 AM
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Google Hangouts version 7.0 is out, and naturally enough there are some new features to try out.
The biggest addition is a new 'quick reply' feature. This lets you tap on a message in the notification bar and compose a reply right there and then, without having to load the app. That's a neat feature, and actually a little like how this kind of functionality works when you're checking out the app through a smartwatch. You'll also be able to get into frequently used conversations quicker, with the ability to add a specific shortcut to your home screen. Just tap on it and you'll be in the window for that chat, without needing to load the main app page first.
These are solid incremental improvements to the well regarded mobile app, which can also be used to sync all of your text messages and other communications. Version 7.0 is being rolled out to select users at the moment and will go wide in the coming days.


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With First Tutors: Music you can search for a Winsford harpsichord teacher. Harpsichord lessons are an excellent way to learn a fun new hobby, pick up a new talent and attain confidence with harpsichord. Use our site to search for Winsford harpsichord teachers and choose which best suits your requirements so you can start your harpsichord lessons in Winsford immediately!
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The last two seasons have been an absolute nightmare for Newcastle fans and after only just escaping relegation a year last May we thought we'd be OK last season when last summer we paid out over £50M to bring some good players in and then spent close to £30M in January to further strengthen the squad.
But the appointment of Steve McClaren by Lee Charnley and the Board as the head coach was just a terrible appointment – a disastrous appointment – and the former England manager simply wasn't good enough.
To cut a long and painful story short – we were relegated in May.
Jonjo Shelvey and Rafa Benitez in pre-season
Rafa is just amazing – he's so positive and upbeat
The really sad part about it was that we had by no means the worst squad in the Premier League and Rafa proved after he came in and we took Spurs apart 5-1 in that final game when we looked like a top six side.
But Rafa was brought in too late and at least for now we are second class citizens in English football and have a big fight on our hands to return to the Premier League next May.
Having smaller clubs with much less history and achievement in the game than Newcastle United – like Hull City, Burnley, Watford, Crystal Palace, Bournemouth, Swansea, Stoke and West Brom in the Premier League is not good.
And for a player to move from Bournemouth to Newcastle in some people's eyes now being seen as a drop down for him is unbelievable.
Who would have thought four years ago that would ever happen?
It's a tough 46 game schedule coming up in the Championship and Jonjo Shelvey has today issued a rallying cry to his team mates to repair the terrible damage that was done last season and in previous seasons at Newcastle.
This is what Jonjo has said:
"I don't think you can feel sorry yourself, and this certainly doesn't feel like a club that's feeling sorry for itself because of what happened."
"We obviously deserved to go down because we weren't good enough last year. It is what it is, and we are where we are, but it's down to us now to put things right."
"We've brought in some tremendous signings, and it's obviously another big plus with the manager staying."
"He'll be giving it his best shot to try to get us out of the Championship. It's down to us now to repay the fans for sticking by us."
"There's nothing better than being back playing games, that's what you want to do as a footballer."
"You want to play as many games as you can in the short space of time before the season begins, because that's the best way to get fit and sharp."
"It's good to be back out there."
We have to remain positive of course and once the season gets underway we can start getting those wins on the board and hopefully start to prove we are on our way back to being a top Premier League club again.
We have every confidence in Rafa Benitez who seems just an amazing man – so confident and upbeat and staying at Newcastle in the second division showed his loyalty to the club, but especially to the fans.
We support Rafa in everything he's doing at Newcastle.
If anybody can return the club to greatness again it's Rafa Benitez.
Comments welcome.


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The hardest natural metal in the universe, and the second hardest in the Omniverse. This metal is virtually indestructible and can only be shattered when subjected to great force. Among all the force other than ZST, only T.S.A.B know how shatter it. Due to it rare natural souced, Durabylium are not widely used by any force other than the ZST. Whom know how to mass-produced the metal.
Characteristic Edit
Durabylium is not a living metal, thus can't reproduced itself. However, when Durabylium come in contact with a spark, it become alive and all the molecure inside it will become nanomachine, thus gained the ability to regenerate. The hardness of Durabylium is legendary however, to warm up a thin cup of tea, constructed using Durabylium, the force equal to 4.4 x 10^69 Joules are needed. THAT MEAN THE ZST NEED A FRICKING BIGBANG JUST TO WARM UP THEIR TEA. To merely destroy one mol of matter constructed using Durabylium, an explosion equal to ten gram of ununtrium are needed. The molar mass of Durabylium is 1 gram / mol.
It because of such hardness, the Zen Seibertron Teikoku, whom the standard of weapon is being able to damaged whatever armor they're using right now, resort to use Ununtrium as their reactor standard and decide to make "Mass Produced Ultra Matrix", an reactor with ouput equal to 100 Kilogram of Ununtrium, per second. The real Ultra Matrix, used by the elites have the ouput of 10 ton of Ununtrium, while the " X Core Ultra Matrix" use by the super elites have the ouput of atleast 100 ton.
Since it the hardest metal in the universe. Durabylium is very rare, only 80 ton of Ununtrium ore are known to exist in the Universe. Due such rarity, it value in the market is high. However, to the ZST, Durabylium are worth less than garbage, because they know process to mass-produced Durabylium with a production rate become to absurdly high, everything they use is now Durabylium. Remember the cup of tea, an incident involved a cup of tea and Bigbang actually happen.
The energy required to shatter Ununtrium is so absurd, the T.S.A.B cannot use conventional science to shatter it. They have to construct an alloy of their own, with power equal to durabylium called Tironium using forbidden knowledge and alot of absurdly complicated science, along magic. Due to the complexity of the Metal, alot of resource has to be used. So much that the T.S.A.B whom has conquered the "Negative Omniverse" can only produced at the same production rate of the ZST.
Mass Production Method Edit
Yes, ZST did have the Mass Production method used to mass produced Durabylium. But their method is so absurd, even they think it absurd. The method is invented by Wheeljack, a crazy scientist that are crazy even by ZST scientific standard. And every single ZST scientist are "mad" to some degree.
To mass produced Durabylium a Cybertronian has to put his "stick shift" into a pile of fertillized Durabylium molded by Wheeljack to look exactly like woman reproductive organ. Why .... because Wheeljack is crazy. When he ejacuate , his "CNA" wil be intergrated into the pile of Metal. Then the metal will use his CNA to produced itself. And ..... YES THEY HAS TO IMPREGNANTING THE FRICKING METAL TO MASS PRODUCED IT.


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RV Lot in Wilderness Rv Resort at Silver Springs
RV Lot for Sale in Silver Springs, Florida
Silver Springs, FL
(Located in Wilderness Rv Resort at Silver Springs)
View on Map
Contact Information
RV Lot for Sale
|41 x 73 ft
|Property ID:
|Posted on:
|May 31, 2011
|Updated on:
|Jul 25, 2016
Property Description
Deeded RV Condo Lot in the upscale 55+ Town Park section of Wilderness RV Resort at Silver Springs The park is in a serene setting on Hwy 40 surrounded by Ocala National Forest and has direct access to the Ocklawaha River for boating or fishing.
Lot has upgraded utilities including 100 amp electric (individual meter) and underground cable. Wi-Fi and phone available.
Motor homes, 5th Wheels, Travel trailers or Park Models are permitted.
Site is 41 X 73 with 6" thick reinforced concrete (10x32 level RV pad plus 20x25 parking area). Lot faces west to maximize shade.
Gated Entry, Club House, Lodge, Social Hall, 2 pools (1 Heated) & Spa, Game room, Fitness Center , Laundry, Horseshoes, Ponds with Fountains. Numerous weekly Social Activities (music, dances, dinners, Bingo, cards, games, crafts- to name a few) in friendly park. Restaurant on site.
Low monthly association fees include cable, water, sewer, lawn mowing, trash etc. Silver Springs Nature Park, Lowes, Wal-Mart and lots of shopping within minutes. Great neighbors in a great neighborhood!!!
New Reduced price $37,900.
Community Information
|Community Name:
|Wilderness Rv Resort at Silver Springs
|Pool, Club House, Laundromat


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Thursday, 20 July, 2017
Sedona's giant screen theater showing an original film on the ...
Score: 14.34 Category: Movies\Theaters
Offers specialty art training taught by instructors who have national ...
Score: 11.71 Category: Visual Arts\Education
Includes MP3 files, photos, a discography and news.
Score: 8.89 Category: Music\Bands and Artists
Offers silent era films on DVD and periodicals on CD.
Score: 8.89 Category: Movies\Genres
Macrophotography of insects and other bugs, plus sunset and Sunrise, ...
Score: 8.89 Category: Photography\Photographers
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Non-profit organization offering diverse art experiences for individuals and the ...
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Score: 6.40 Category: Photography\Equipment and Services
Collection of online indie streams, from Radio K.E.L.T. playing Celtic ...
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A South Florida artist specializing in 15 different styles of ...
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Provides Large image gallery.
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Very Large non-commercial site for beading and fiber arts.
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Large index of work, submissions welcome.
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A Large database of searchable lyrics for all genres of ...
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text:
Mental Health
Have Mental Health Questions? Ask a Psychiatrist Online
Sorry I had not accepted sooner, but was feeling as if you didn't really respond to my original question as to whether I should go back to Nardil or not. There is so much controversy when I google Nardil, and have seen quite a few people even these days who are going on it due to non effective results from the newer meds. I have since spoken to my daughters who agree that it would be better to switch psychiatrists before I decide about the medications. Perhaps what I need most is someone who is a good listener instead of a pill pusher to assist me in my journey to find peace from this malady. Thanks for your help anyway.


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UPDATE: The Rods are Gone. Only Curtains left 🙁
Need to score some new window treatments? Lots of 2-packs of Curtains and Rods are on sale for just $9.99 at Kohl's (reg. price $39.99.) Even better, there are tons of overlapping offers that can score them as low as $4.70 each! In fact, I'm going to show you a scenario in this post where you can get four sets of curtains and four rods.
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Will Nortel's Contivity VPN Client work with Cisco's VPN 3000 concentrator?
Unanswered Question
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Hi, need help. We have VPN 3000 concentrator and a number of VPN clients (these are using Cisco VPN client).
We have one user that wants to use Nortel's Contivity VPN Client. Will this work with the Cisco COncentrator 3000?
I have this problem too.
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Adventures of a time traveling elf
A lowly stable elf finds that he is the only one who can stop an invasion of the North Pole by using the secret of Santa's Sleigh, a TimeGlobe, to travel back in time to Save Santa - twice.
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Materials & Chemicals Market Research Reports & Industry Analysis
The materials industry and market includes building and construction materials used worldwide for the fabrication of structures, earth supports, embankments, and completion of excavations. Heavy industry materials for construction are diverse and range from readily available non-supply chain materials such as brush and mud to commodity supply materials procured for projects like construction aggregates, composite wood products, plastics (PVC), resins, synthetic textiles and fibers (fiberglass), composite cements, other plastics and polymer composites, concrete, and various metals. Heavy industry metal materials include iron, various grades of steel, specialty alloys, titanium, copper, and even gold, silver, chrome and platinum. Glass, ceramic materials and foam are also subsets of heavy industrial materials required for construction. Finished materials for construction projects can included coated glass, architectural glass, other finished specialty glass projects, cast and molded steel (re-bar and beams), pipe sections, blocks, bricks, tiles, flooring, drywall panels, piles, poles, pillars, and wires.
Radical materials advances can drive the creation of new products and new industries. Industrial applications of materials science include materials design, cost-benefit tradeoffs in industrial production of materials, processing techniques (casting, rolling, welding, ion implantation, crystal growth, thin-film deposition, sintering, glassblowing, etc.), and techniques such as electron microscopy, x-ray diffraction, nuclear microscopy (HEFIB), backscattering, neutron diffraction, etc.
The chemical industry comprises the companies that produce industrial chemicals. The chemical industries convert raw materials oil-- metals, air, water, natural gas and minerals-- into products. Products include chemicals to make plastic for computers, paint for cars, and medicines. Chemical engineers start with cheap, raw, natural materials, such as petrochemicals, seawater, and minerals.
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Materials & Chemicals Industry Research & Market Reports
2017 U.S. Softwood lumber, rough materials used by the Millwork Industry-Materials & Manufacturing Report
...timely and accurate industry statistics, forecasts and demographics. The report features 2017 current and 2018 forecast estimates on Softwood lumber, rough materials used by the Millwork industry nationally and for all 50 U.S. States and ... Read More
Global Hydrogen Peroxide Market 2017-2021
...are minimized. However, like other oxidizing chemicals, if handled incorrectly, hydrogen peroxide can pose a serious hazard to human health, safety, and environment. Technavio's analysts forecast the global hydrogen peroxide market to grow at a ... Read More
Global Agrochemicals Market 2017-2021
...classified as fertilizers and pesticides. Fertilizers are segmented into three categories, which include nitrogenous, phosphatic, and potassic. Different segments of pesticides include insecticides, herbicides, fungicides, and others. Technavio's analysts forecast the global agrochemicals market to ... Read More
Global Pulp Market 2017-2021
...are essential for the production of paper. Lignin, on the contrary, is a type of polymer that binds cellulose fibers together. Hemicellulose, like cellulose, is a carbohydrate-based polymer that binds with cellulose fibers. These elements ... Read More
Organic Fertilizers Market by Source (Plant, Animal, and Mineral), Form (Dry and Liquid), Crop Type (Cereals & Grains, Oilseeds & Pulses, and Fruits & Vegetables), and Region (North America, Europe, Asia-Pacific, and RoW) - Global Forecast to 2022
...Global Forecast to 2022 "The organic fertilizers market is projected to grow at a CAGR of 12.08% during the forecast period." The organic fertilizers market is projected to grow at a CAGR of 12.08% from ... Read More
Aircraft Insulation Market by Type (Thermal, Acoustic & Vibration, Electric), Material (Foamed Plastics, Fiberglass, Mineral Wool, Ceramic-based Materials), Application Area (Airframe, Engine), Platform and Region - Global Forecast to 2022
...is projected to grow at a CAGR of 5.79% from 2017 to 2022" The aircraft insulation market is estimated to grow from USD 7.46 billion in 2017 to USD 9.89 billion by 2022, at a ... Read More
Glass Mat Market by Mat Type (Chopped Strand, Continuous Filament), Binder Type (Emulsion, Powder), End-Use Industry (Construction & Infrastructure, Automotive & Transportation, Industrial & Chemical, Marine), and Region - Global Forecast to 2022
...mat market projected to register a CAGR of 4.83% during forecast period" The glass mat market is projected to reach USD 1,238.5 million by 2022, at a CAGR of 4.83% between 2017 and 2022. The ... Read More
Specialty Chemicals – A Global Market Overview
...19-month period between December 2007 and June 2009, recognized as the Great Depression, hit a body blow to the Specialty Chemicals industry. Given the niche nature of the sector and the high-value products comprising it, ... Read More
Global Zinc Metals Report Q3 2017
...to USD2,900/tonne by2021. Latest Developments & Structural Trends Price Forecast We forecast zinc prices to average USD2,700/tonne in 2017, however highlight key risks to both theupside and downside over the coming months. Beyond 2017, we ... Read More
Global Cryogenic Hoses Market 2017-2021
...and carbon dioxide. Cryogenic technology is majorly involved in the production, maintenance, and application of low temperatures below 150C. There has been an increase in scope of cryogenic applications from cold storage to core processes ... Read More
Global Industrial Gas Sensors 2017-2021
...prevent any accident or injury. By type, the gas sensors are segmented into oxygen, carbon dioxide, carbon monoxide, and others. By technology, the gas sensors have been divided into electrochemical, semiconductor, infrared, PID, and others. ... Read More
Global Construction Glass Market 2017-2021
...solar control, safety and security, fire resistance, noise control, chemical resistance, electric resistance, interior design, flexible molding, and stability in changing climatic condition. The construction sector is one of the major end-users of glass. Almost ... Read More
Constantia Flexibles Group GmbH in Packaging (World)
...it will be key for the group to not just seize opportunities but also to create these opportunities through innovation and further collaboration with its clients. Euromonitor International's Constantia Flexibles Group GmbH in Packaging (World) ... Read More
Global Rigid Plastic Packaging (RPP) Inks and Coating Market 2017-2021
...products. Inks and coating provide specific information, symbols, and brand value about the packaged product being stored, transported, and sold. Barcode and electronic data interchange, with the help of inks and coating, on rigid plastic ... Read More
China Petrochemicals Report Q3 2017
...ethylene output remains at thislevel, with the expansion of ethylene capacity to around 26mn tpa in 2017 there is the danger that the rateof cracker capacity utilisation will drop below 70%. The reduction in ethylene ... Read More
United Kingdom Petrochemicals Report Q3 2017
...created significantuncertainty for the sector. The minority government elected after an unexpected snap election in June 2017has added to the problems, although the industry may feel more reassured that the likelihood of a 'softBrexit' has ... Read More
Ready-Mix Concrete Manufacturing in the US - Industry Market Research Report
...activity in residential, commercial and institutional construction markets, as well as on the level of infrastructure and utilities construction. These markets rely on concrete as a main input for foundation, suspended flooring and pavement construction. ... Read More
Global Medical Gas Equipment Market 2017-2021
...market. This is due to the use of medical gas to help patients with diseases such as asthma, COPD, and sleep apnea. Medical gas equipment is used for therapeutics, diagnosis, and other applications such as ... Read More
Europe Paints And Coatings Market Forecast 2017-2024
...at a CAGR of 4.42%, during the forecast period 2017-2024. The forecast period for the market is from 2016 to 2025 and the base year deliberated for the market study is 2016. The flourishing automobile ... Read More
Asia-pacific Tackifiers Market Forecast 2017-2024
...the packaging industry for pressure sensitive adhesives and recent up-gradations of hydrocarbon producing plants are some of the key factors expected to drive the growth of the Asia-Pacific tackifiers market. Tackifiers have characteristics like low ... Read More
Global Electroactive Polymer Market Forecast 2017-2025
...is estimated to rise from $3435 million in 2016 up to $6370 million by 2025. The augmented usage of touchscreens and the cost-effective and lightweight polymers produced by the EAP technologies are some of the ... Read More
Europe Tackifier Market Forecast 2017-2024
...grow during the forecast period of 2017-2024. Recent up-gradations of hydrocarbon producing plants and the growing consumption of tackifiers in the packaging industry for pressure sensitive adhesives are few of the key reasons anticipated to ... Read More
Global Vehicle Lightweighting - Technology, Trends And The Future
...and suppliers involved, and material content forecasts out to 2030. Based on exclusive interviews, primary research and proprietary data this study includes: Material developments including aluminium, carbon fibre, magnesium, organics, plastics, composites and steel A ... Read More
North America Electroactive Polymer Market Forecast 2017-2025
...a CAGR of 7.52% during the forecast period of 2017-2025 and predicted to be worth $4362million by the end of 2025 MARKET INSIGHTS The U.S is the major consumer for this market with an accounted ... Read More
Automotive Light-vehicle Sensors - Technology, Trends And Forecasts To 2031
...materials and suppliers involved, and material content forecasts out to 2029. Based on exclusive interviews, primary research and proprietary data this study includes: Material developments including aluminium, carbon fibre, magnesium, organics, plastics, composites and steel ... Read More


text: Snickerdoodle Designs is created by designer Karen. Karen is fascinated by color and texture, so she loves to incorporate both into papers that are beautiful, but don't complete with a kits elements or a scrappers photographs. Like most designers, there are many and varied things that will inspire her. There isn't just one thing. But, in general, the 3 things that inspire her most are music, quotes, or feelings.


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4 guests maximum
67 m2
2 bedroom apartment
1 bathroom
1 double bed
2 single bed
A few words about the apartment…
The people back home will be jealous when they see where you'll stay during your holiday in Barcelona. This spacious apartment has a stunning interior and an amazing location. It is in a beautiful area nearby the famous Sagrada Família. Enjoy!
Check-in / Check-out
The standard check-in time is from 15:00 and the check-out by 11:00.
Arrivals and departures outside this standard time are always tried to be accommodated on request.
Refundable damage deposit upon arrival : € 150.00 cash. The damage deposit will be returned at check-out.
City tax : please check details after clicking the "book now" button
Please note : non smoking, pets are not allowed, no parties please, no young groups
Facilities and amenities
- Internet
- Pets allowed
- Smoking allowed
- International TV
- Air conditioning
- Heating
- Fan
- Bed linen
- Towels
- Baby cot
- Washing machine
- Dryer
- Dishwasher
- Microwave
- Oven
- Complete kitchenware
- Balcony
- Terrace
- Garden
- Swimming pool
- Parking
- Lift (apt. is on 2nd floor)
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Nanoparticle drug delivery offers a potential solution in the treatment of cancer. Using a heterotopic tumor model for head and neck squamous cell carcinoma (HNSCC), tumors of variable folate binding protein–alpha (FBP-α) have been treated to delineate receptor necessity as well as efficacy and toxicity of folate targeted chemotherapy.
UM-SCC and ATCC cell lines were screened using quantitative real-time polymerase chain reaction for FBP-α expression. Acetylated generation 5 dendrimers conjugated to the targeting moiety folic acid and the therapeutic moiety methotrexate were fabricated and administered to SCID CB-17 mice inoculated with UM-SCC-1, UM-SCC-17B, and UM-SCC-22B cancer cells. Mice were injected with targeted therapy, free methotrexate, or saline control and monitored for drug efficacy and toxicity.
Targeted therapy was effective relative to receptor level expression. Targeted therapy could be delivered in molar doses 3 times that of free drug. The treatment of a high folate expression tumor cell population was noted to have increased efficacy over saline (P < .01) and free methotrexate (P = .03) as well as decreased systemic toxicity.
This report represents the first translation of dendrimer-based chemotherapy to HNSCC and underscores its effectiveness as an antitumor agent in human cancer cell lines with lower levels of FBP-α than the in vitro and in vivo models previously reported.
A tremendous need exists for new treatment strategies in the management of squamous cell cancer of the head and neck (HNSCC). It is the sixth most common malignancy in the world and has a mortality rate that is basically unchanged over the past 30 years.1 In addition, elimination of suffering from this disease will require modalities that not only control cancer but do so in a manner that eliminates systemic toxicity. Current approaches lead to morbidity associated with chemotherapy, the localized destruction of peritumoral tissue via radiation, and the attendant disfigurement associated with surgical therapies. Chemotherapeutic agents that specifically target and concentrate in tumor cells are a feasible and attractive alternative to standard chemotherapy and leave normal tissue unaffected. It is hypothesized that such an approach would reduce systemic toxicity and maintain or increase treatment efficacy.
Advances in nanoparticle drug delivery offer a potential vehicle for targeted therapy. Dendritic noncationic biocompatible polymers (dendrimers) can now be synthesized in large quantities of uniform structure and design and can be conjugated to targeting ligands (Folate, EGF, RGD peptides, etc), imaging agents (Au and Fe), and therapeutics (Taxol, cisplatin, methotrexate, etc)2 (Fig 1). Tumors expressing the specific biomarker of the high-affinity folate binding protein-alpha (FBP-α) have been targeted through this technology, demonstrating a significant increase of therapeutic efficacy and decrease in systemic toxicity.3
We hypothesized that dendrimer targeted therapy would be efficacious and decrease systemic toxicity in an animal model for HNSCC. To test this hypothesis, we 1) screened and identified cell lines with variable expression of the folate receptor target, 2) tested in vivo efficacy of targeted chemotherapy to 3 cell-line xenografts with variable folate receptor expression (no, intermediate, and high expression), and 3) validated the most responsive tumor in a dose-ranging efficacy and toxicity study compared with standard methotrexate.
A G5 polyamidoamine (PAMAM) dendrimer was synthesized and purified from low molar mass contaminants as well as higher molar mass dimers or oligomers. The synthesis and purification was identical to previously published protocols and performed by the same personnel.3 The average molar mass of the dendrimer was determined to be 26,530 g/mol by size exclusion chromatography using multiangle laser light scattering, ultraviolet, and refractive index detectors. The average number of surface primary amine groups in the dendrimer was determined to be 110 using potentiometric titration along with the molar mass. The polydispersity index, defined as the ratio of weight average molar mass and number average molar mass for an ideal monodisperse sample, equals 1.0. The polydispersity index of G5 dendrimer was calculated to be 1.032, indicating a narrow distribution around the mean value and thus confirming the high purity of the G5 dendrimer. The surface amines of G5 PAMAM dendrimers were acetylated with acetic anhydride to reduce nonspecific binding of the polycationic dendrimer. The ratio between the acetic anhydride and the dendrimer was selected to achieve different acetylation levels from 50 to 80 and 100 primary amines. After purification, the acetylated dendrimer was allowed to react with an activated ester of folic acid, and the purified product of this reaction was analyzed by 1H nuclear magnetic resonance (NMR) to determine the number of conjugated folic acid molecules. Subsequently, methotrexate was conjugated via ester bond as described previously.4 The quality of the PAMAM dendrimer conjugates was tested using polyacrylamide gel electrophoresis, 1HNMR, 13C-NMR, and mass spectroscopy. Capillary electrophoresis was used to confirm the purity and homogeneity of the final products. The folic acid–targeted conjugates specifically contain the following molecules: G5-(Ac)80-(FA) 5-MT × 5, identified with the acronym G5-FA-methotrexate (MTX).
UMSCC cell lines were generously supplied by Dr Thomas Carey at the University of Michigan Head and Neck Cancer SPORE. All other lines were obtained directly from the ATCC. Lines were chosen with the goal of obtaining a variable expression pattern of the FBP-α receptor, which we anticipated would be the targeted receptor on the cell for our targeted chemotherapy.
Cell lines were subcultured in 5% CO2 humidified incubator at 37°C, Corning 75 cm2 tissue culture flasks 430641, 15 mL folate-free RPMI 1640 with L-glutamine and phenol red 27016-021 supplemented with Gibco 5% FBS US origin and heat-inactivated 10082-147; 100 U/mL penicillin-streptomycin Gibco 15140-122; 1× final concentration of MEM nonessential amino acids Gibco 11140-050: "Cell Culture Media." Cell culture media was changed 3 times per week, and the cell lines were passed at ~70% confluence to maintain log-phase growth conditions. Cells lines were subcultured in the previously noted conditions for 10 to 14 days before testing or inoculation into mice. Cell lines were tested for mycoplasma contamination using Myco-Alert assay LT07-218 Cambrex and independently verified by polymerase chain reaction (PCR). Cell lines with mycoplasma contamination were treated with Plasmocin (InvivoGen, San Diego, CA) according to manufacturer's instructions, followed by retesting before use for study.
Quantitative real-time (qRT) PCR was used to screen 11 HNSCC tumor cell lines for FBP-α expression with the goal of identifying no expression, intermediate expression, and high expression lines for testing targeted therapy in xenograft animal models. Cepheid SmartCycler (Sunnyvale, CA) conditions: stage 1: 95°C for 120 seconds, stage 2: temp cycle repeat 45 times, 95.0°C for 15 seconds, 66.0°C for 15 seconds, 72.0°C for 25 seconds with optics on, stage 3: melt curve 60.0°C to 95.0°C at 0.2°C/second with optic ch 1 on. Dye: Sybr Green: (Invitrogen) reaction conditions: 1.5 ng of RT product, 2.25 µL 10 × PCR buffer, 2.5 µL 50 nmol/L MgCl2, 0.5 µL 10 mM dNTP, 3′ and 5′ primer 1 µL each, 1 µL 1/800 Sybr/TE pH 8.0, 5 µL 5× additive reagent, 1.25 U platinum Taq (Invitrogen).
Primer: β-actin product size = 500 tgcatcctgtcggcaa sense, tacgcctctggccta antisense; Primer: FBP-α gcatgtgaatgcaggtga sense, acgggctttctaggcaa antisense. PCR primers are designed to span genomic portions of DNA such that extracted and subsequently transcribed mRNA that is contaminated with genomic RNA results in a 300-bp larger amplicon (800 bp total), whereas a "pure" mRNA extraction results in a 500-bp amplicon. Integrity and specificity of the primer design for folate-α and β-actin are then tested by amplification using PCR. Amplicons are gel extracted and sequenced for their entire lengths of 500 bp. Sequencing results are BLASTed against all known sequences and found to be specific for the proteins of interest. No qRT-PCR data were reported that failed to provide a single, sharp melt curve at the appropriate temperature as provided by the Cepheid software immediately after amplification.
All animal testing was performed under the guidelines and within the facilities of the University of Michigan Unit for Laboratory Animal Medicine in U.S. Department of Agriculture and the Association for Assessment and Accreditation of Laboratory Animal Care certified pathogen-free environments. Mice were purchased from Charles River and delivered to the facilities directly. The strain of mice is CB-17 SCID; mice were female with an age range of 29 to 35 days.
Xenograft tumor growth models were used to demonstrate the efficacy and toxicity of targeted methotrexate chemotherapy versus standard chemotherapy with methotrexate. In our first set of animal experiments, xenografts of no folic acid receptor expression (UM-SCC-22B), intermediate folic acid receptor expression (UM-SCC-1), and high folic acid receptor expression (UM-SCC-17B) were compared with each other with saline control. In the second experiment, dose ranging of the most sensitive line was tested to validate our hypothesis of increased efficacy and decreased toxicity of targeted therapy compared with standard methotrexate chemotherapy.
Verified mycoplasma free cell lines were inoculated into the hind flanks of 29- to 42-day-old female CB-17 SCID (Charles River) mice in a pathogen-free animal laboratory. The cell lines were sterilely prepared for inoculation with 0.9% injectable sodium chloride USP to a concentration of 4 × 106 per 100-µL injection site. The hind flank injections were carefully administered so as not to puncture the subdermal tissue, thereby mediating intraperitoneal invasion. The subsequent tumors were measured in millimeter increments by a digital caliper weekly in the x, y, z axes to establish tumor volume and therefore compare the results of treatment by targeted chemotherapy and control standard methotrexate on tumor growth; treatment was initiated when the tumors reached a size of approximately 100 mm3 per inoculation site, this size was achieved in 7 to 10 days.
Five times per week (daily Monday through Friday) SCID mice with UM-SCC xenografts received injections of either dendrimer targeted MTX, free MTX, or saline control based on previously identified daily dosages with known toxicity profiles in the animal model. The compounds were delivered in a 0.2-mL volume of saline. Molar ratios of MTX were calculated for all doses delivered according to the number of MTX molecules present in each nanoparticle. In each trial, up to 6 mice per group based on statistical design with significant P value set at 0.05 received a total of 20 injections (dependent on survival). The body weights and tumor volume of the mice were monitored twice per week as an indication of positive and adverse effects of the drug. Histopathology of the tumor and multiple organs was done at the termination of the trial with tissues from the tumor, lung, heart, liver, spleen, kidney, intestine, brain, and muscle examined.
Data were placed into SPSS software for statistical analysis. Means, SD, and SEM of the data were calculated. Differences between the experimental groups and the control groups were tested using Student's-Newman-Keuls' test, and P values less than .05 were considered statistically significant.
Using our primers for FBP-a, 11 HNSCC cell lines (Table 1) were screened for comparison of FBP-α expression. Of these lines, HNSCC lines showed low levels of expression compared with other tumor types known to express FBP-α. Specifically related to KB cells that had been studied previously, the expression of FBP-α in HNSCC was 1000-fold less. HNSCC lines did reveal variable expression patterns of FBP-α, with UM-SCC-22B having no expression and UM-SCC-17B with the highest level of expression (Fig 2).
On the basis of qRT-PCR results, 3 cell lines were chosen for study using a relatively no, intermediate, and high FBP-α expressing cells considering only HNSCC lines. This study confirmed our hypothesis that folate expression was relevant to targeted therapy tumor responsiveness. Compared with saline control, targeted therapy had no effect on UM-SCC-22B, intermediate effect on UM-SCC-1, and strong effect on UMSCC-17B (Fig 3).
With the necessity of receptor expression for targeted therapy confirmed, we explored further the effects of targeted therapy in the highest FBP-α expressing HNSCC line UM-SCC-17B using high and low doses of free MTX and targeted therapy versus saline control. In this study, we demonstrated the ability to deliver targeted MTX at doses in molar doses 3 times the dose of free MTX (considering equimolar molar ratios) with significant increases in tumor control efficacy (Fig 4) and decreases in systemic toxicity (Fig 5). For example, 3.33 mg/kg/d free MTX was lethal at 2 weeks, whereas the animals receiving 160 mg/kg/d targeted therapy survived the 28-day trial. Both low- and high-dose targeted therapy demonstrated tumor control better than saline or free MTX, but only high-dose targeted therapy demonstrated a statistically significant increase in tumor control versus saline (P < .01) and free MTX (P = .03).
In this study, we tested the hypothesis that FBP-α was found in HNSCC and could therefore be targeted similar to previously published results in vitro and in vivo in KB cells. We validated our hypothesis by identifying cell lines with variable expression of FBP-α, demonstrating varying degrees of tumor control attributable to receptor expression in a xenograft mouse model and validating increased efficacy and decreased toxicity compared with standard MTX chemotherapy. This report represents the first translation of dendrimer targeted MTX chemotherapy to an animal model for HNSCC and has many important ramifications for this emerging technology.
From a folic acid receptor perspective, significant differences exist between KB cells and UM-SCC-17B, which were validated in this project. KB cells are known to highly overexpress FBP-α, especially in the face of folate deprivation. In contrast, UMSCC-17B, although the highest of any of the UMSCC cell lines we tested, expresses FBP-α at mRNA levels approximately 1000-fold less than KB and does not upregulate FBP-α in response to low folate levels even when these levels are maintained over weeks to months (data not shown). Pertinent to this, in our study model, we did not require folate deprivation of animals to demonstrate drug effect.
We used mRNA levels to predict efficacy of targeted therapy given that escalating antitumor effects correlated with mRNA expression of FBP-α. Whether mRNA levels correlate exactly to receptor number and activity in the chosen cell lines is unknown given post-translational modifications and receptor kinetics. Previous testing in our laboratory has demonstrated similarities in mRNA level and receptor activity for HNSCC lines using radiolabeled assays but was not specifically addressed for each of the lines in this study. Regardless, our results here support the concept that mRNA testing may have predictive value in identifying potential responders to this therapy. This would be particularly helpful given that not all HNSCC tumors overexpress FBP-α and intermediate expression did not offer a significant tumor control advantage. If further validated, one could envision a clinical scenario in which biopsies could be screened for upregulated receptor levels, guiding the targeting agent of choice with the possibility of multiple targets, with dendrimers providing an interchangeable platform. At minimum, our work supports the concept that qRT-PCR could be used to select patients who would not be amenable to an FBP-α targeted approach because of their absolute lack of FBP-α for targeting.
Two important additional findings in our study should be noted. First, 1 mouse in the low-dose treatment group had near complete tumor regression in the 30-day trial. This result is similar to the previously published results with KB in which the only mice that survived a 100-day trial were those treated with targeted therapy.3 In that study, 2 mice where deemed complete responders, whereas others in the same group continued to experience tumor growth. Second, in our studies, equimolar tumor effective doses were less toxic than free drug, similar to the results of previous studies. One of the significant advantages reported with targeted therapy is decreased systemic toxicity. Given tumor control, if systemic toxicity can be limited, then morbidity and human suffering associated with disease treatment can be decreased.
Dendrimer targeted approaches offer great promise to cancer therapy overall. Our results suggest that dendrimer targeted therapy is feasible in an animal model for cells that overexpress FBP-α at the mRNA message level even if these levels are far below the previous model in KB cells. This result is significant because it has the potential to dramatically increase the number of tumor types that could be treated with folate targeted chemotherapy. KB tumor characteristics of extremely high levels of FBP-α overexpression are not required for clinical effect and are not necessary to achieve decreased systemic toxicity. Our findings with the UM-SCC-17B cell line demonstrate that differential targeting can be had at more modest levels of FBP-α overexpression.
A large number of biomarkers have been identified and are under study, underscoring the numerous possibilities for targeted therapy with a dendrimer-based approach. Looking at HNSCC alone, Chin and Boyle et al analyzed the expression of more than 13,000 genes that gave rise to 1260 with differential expression in HNSCC, including many cell surface receptors (EGF receptor, interleukin-1 receptor, insulinlike growth factor binding protein, thyroid hormone receptor, and integrin alpha-6).5 Although these markers may not in themselves be transforming, it is hypothesized that they are overexpressed in response to the metabolic demands of a persistently dividing cell. Given the presence of differentially expressed biomarkers in rapidly dividing cells, it is suggested that targeting of these receptors may also be possible as a substitute or in conjunction with FBP-α.6–8
Methotrexate was chosen as the therapeutic in this study and has been demonstrated to be an effective for treatment of HNSCC in preclinical and clinical settings. Like many chemotherapeutic agents for cancer, systemic toxicity significantly limits its application. Although other therapies have now superseded MTX as primary treatment, the possibility of delivering targeted MTX while decreasing overall systemic toxicity could potentially overcome the previous limiting nature of the therapeutic and was part of the rationale for the therapy choice. In addition, alternative dendrimer conjugates have been created with Taxol,9 docetaxel, and cisplatin with plans for a number of additional therapeutics being considered for future development.
Recent advances in directed chemotherapy for cancer have demonstrated the ability to deliver chemotherapy in vitro and in vivo with increased efficacy and decreased toxicity over standard chemotherapeutic approaches in a number of cancers, including lung cancer,10 colon cancer,11 and head and neck cancer.12 It is likely that with continued development, targeted approaches will become the mainstay of cancer therapy. Dendrimer-based therapy has great potential in this regard because of the ability to conjugate alternative targeting agents and therapeutics to a single carrier device. A number of alternative targets are under exploration using dendrimer-based approaches, which may allow us to modify therapeutic modalities (both the receptor targeted and therapeutic utilized) in the future according to the genetic makeup of the tumor characteristics. This study highlights a mechanism for clinical application by the selection of a tumor for therapy based on mRNA expression of the desired target. In the future, screening of tumors for a large number of potential targets could be possible with dendrimer targeted therapy, selected specifically on the basis of receptor expression and tumor responsiveness to drug. We are currently continuing our animal work to delineate the therapeutic index of this therapy more effectively and to expand our research to other receptors for targeting.
This work was supported by the University of Michigan Head and Neck Cancer SPORE (NIH/NCI Grant No. CA97248-01).
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


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Originally called Hansel and Gretel, Hummel Surprise figurine will be a heart-warming addition to your home. The little girl and her basket is protected by her big brother with his arm around her shoulder as they gaze in wonderment.
Numerous hours are spent in the creation of each Hummel keepsake to ensure pristine quality and attention to detail. Each element is hand painted and inspected thoroughly by superbly trained craft workers. And finally, the pieces are individually signed by the ornament's master painter to ensure authenticity.
5.5 Inches Tall
Hand Painted
Individually Numbered and Signed


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we're home. safe and sound. and before the stupid weather came back.
still settling in... know that might take some time.
found out that i have a new family member that blogs. check out two benny bean photos here.
thanks megs. ;o) means i don't have to upload pics right now... a new thing to add to the growing to do list. which includes hitting babies r us soon!
Around the World Blog Hop - Thoughtful Branches
11 months ago


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Sabres rally late, top KingsNov 20, 2010 - 6:28 AM
Thomas Vanek, Jochen Hecht and Patrick Kaleta also tallied for the Sabres, who have won three consecutive home games after beginning the season 0-6-1 at the HSBC Arena.
Jason Pominville collected two assists in the win, and Ryan Miller made 34 saves.
Dustin Brown and Wayne Simmonds lit the lamp for the Kings, who have notched only one win in their last 12 trips to Buffalo. Rookie Jonathan Bernier, the 11th-overall pick in the 2006 draft, allowed four goals on 26 shots to take the loss.
"We have to get better at shutting teams down when we do have the lead," said Kings forward Anze Kopitar.
Los Angeles has dropped three straight games for the first time this season.
While the Sabres were on a power play, Pominville let go a shot from atop the right circle that deflected off a body in front and was slowed down by Bernier. Connolly crashed the crease and nudged the puck across the goal line to put Buffalo up 3-2 at 2:10 of the third period.
Hecht ripped a one-timer past Bernier to make it 4-2 with 4:39 remaining.
"That's the best third period we've played (at home)," said Buffalo head coach Lindy Ruff. "I didn't like the way we started. We weren't clicking, we weren't working."
Brown gave the Kings a 1-0 lead, pushing the puck along the right-wing boards and snapping a wrister from the faceoff circle that sailed between the arm and torso of Miller at the 4:57 mark of the first period.
Buffalo tied the game 37 seconds into the middle stanza. Sabres defenseman Andrej Sekera drifted in from the left circle and fired a low shot that went in off Kaleta.
Simmonds scored on a shot from between the circles to give the Kings a 2-1 lead at 8:25 of the second period. The Sabres responded a little less than seven minutes later on the power play, as Vanek tipped in Derek Roy's slap shot from the point.
Game Notes
Buffalo improved to 5-3-1 in November after going 3-7-2 during the season's first month...Los Angeles forward Justin Williams had a career-high 11-game point streak come to an end...The Kings suffered their first loss in six games against an Eastern Conference team this season.
Nov 19 10:03 PM
- Buffalo Goal - Jochen Hecht (2), at 15:21.
Kings 2, Sabres 4 3rd - 4:39Nov 19 9:56 PM
- Buffalo Power-Play Goal at 2:10.
Kings 2, Sabres 3 3rd - 17:50Nov 19 9:32 PM
- 60
rootsRUWTbot Took away 90 roots
Kings 2, Sabres 2 3rd - 20:00Nov 19 9:28 PM
End of Regulation
Nov 19 9:11 PM
- 150
rootsRUWTbot Added 139 roots (Overtime)
Kings 2, Sabres 2 End of Reg.Nov 19 9:11 PM
- Buffalo Power-Play Goal - Derek Roy (10), at 15:22.
Kings 2, Sabres 2 2nd - 4:38Nov 19 9:06 PM
- 11
rootsRUWTbot Added 11 roots
Kings 2, Sabres 2 2nd - 4:38Nov 19 9:06 PM
- Los Angeles Goal - Wayne Simmonds (4), from Peter Harrold at 8:25.
Kings 2, Sabres 1 2nd - 11:35Nov 19 8:49 PM
2nd Period - 19:23
Kings 1, Sabres 1 2nd - 19:23Nov 19 8:34 PM
End of 2nd
Nov 19 8:15 PM
- Los Angeles Goal - Dustin Brown (9), from Anze Kopitar at 4:57.
Kings 1, Sabres 0 1st - 15:03Nov 19 7:47 PM
1st Period - 20:00
Nov 19 7:39 PM
Related News
- Blues hope goalie change can slow down Sharks top line May 21
- Kings agree with coach Darryl Sutter on contract extension May 13
- Capitals assistant Reirden a 'future head coach' in the NHL May 13
- Buffalo Sabres home arena changing names to KeyBank Center May 11
- Capitals get playoff payoff from Williams against Penguins May 8
- Kings GM: Coach Darryl Sutter has contract offer to return May 6
- Pietrangelo logs heavy ice time in Blues' playoff run May 3
- Pietrangelo logs heavy ice time in Blues' playoff run May 2
- Barkov, Eriksson, Kopitar are Lady Byng finalists Apr 30
- Doughty, Karlsson, Burns finalists for Norris Trophy Apr 29
- Buffalo Sabres re-sign forward Johan Larsson to 1-year deal Apr 29
- Bergeron, Kesler, Kopitar are Selke Trophy finalists Apr 28


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2 Min Read
LOS ANGELES (Hollywood Reporter) - Jon Heder, who starred in "Napoleon Dynamite" and skated opposite Will Ferrell in "Blades of Glory," is venturing into digital entertainment as the star of the zombie comedy "Woke Up Dead."
The scripted online series, created by John Fascano and being produced by Electric Farm Entertainment, centers on a University of Southern California student who wakes up underwater in the bathtub one morning and suspects that he might be dead.
"Dead," which was developed with Heder in mind for the lead, will comprise 50 three-minute episodes for online and mobile distribution in the U.S.
The sci-fi comedy thriller marks an evolution for Electric Farms because it's live-action with limited CGI elements. (Its first online drama, "Afterworld," is a 2.5-D-animated series, while the sci-fi "Gemini Division," starring Rosario Dawson, features elaborate 3-D animated backgrounds.)
Sony Pictures TV International is co-producing and will internationally distribute "Dead" on mobile, broadband and traditional TV.
Heder recently wrapped the feature comedy "When in Rome," which stars Kristen Bell.
Reuters/Hollywood Reporter


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The Practice and Principles of the Lord's Supper
Need help? Visit our Audio Help or F.A.Q. pages. In addition to the audio and text files below, this complete series is also available:
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The Lord's Supper - Its Practice and Principles -
Related Resources
Other sermons from Preach The Word on The Lord's Supper: Celebrating The Supper Of The Lord
See also this helpful article on 'The Lord's Supper' adapted from a sermon by Harry Ironside
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The Fall Fair Party 2011 is on Club Penguin already. At this party you have to collect tickets by playing Fall Fair exclusive games and use the tickets to buy all the items available, or just the ones you want. The party is available for both members and non-members, but non-members have some restrictions like: no access in the circus where there are 2 more rooms and couple of more items at a members-exclusive prize booth. This is how to get the most of the party. This is a picture of the Town during the party:
The most of the Fall Fair is at the Forest where you can got to the Circus (only members), but there's the prize booth for non-members there. Take a look:
Now to get the tickets, I recommend playing any game you like, but if you don't have time for that, I recommend playing Puffle Paddle since it gives you the most tickets. After you're done playing, stop by the non-members prize booth at the Forest. This is what is has:
This is what members can get at the circus entrance booth:
There are two hidden items at the member's prize booth. This is how to get them:
This is how to find the plush turtle: click on the second red flag from left to right.
This is how to find the red balloon: click on the second white flag from right to left.
This is how to get a special background called Step Right Up Background. You need to go to the Ski Village and take a photo of yourself by clicking the camera in the front of the Rockhopper Cut-Out.
Then this message will pop up and you'll have to click "Yes". Just regular Club Penguin stuff…
There is also a pin that you can get at the Fall Fair 2011. Just go to the Coffee Shop and throw snowballs at that big machine. About 5-6 snowballs should be enough, just don't miss.
And now the machine will make you a snow cone. And when you waddle to the snow cone, you will be able to get it.
These are the cheats for Fall Fair 2011, but remember that more items will come at the Prize Booths, both of them.
-Andreylaur, Blog Owner


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Will Apple Inc. Deliver Blowout Q4 Earnings?
- Apple is likely to beat on earnings/revenue in the next two quarters.
- Fundamentals position investors favorably with iPhone revenue likely to grow in mid-teens.
- Investors should remain cognizant of volatility over the long run.
While the consensus view is fairly consistent and more narrow when it pertains to iPhone shipment estimates/forecasts there's a heightened degree of variability when it comes to average unit pricing. This is due to recent trends in channel checks, Samsung Galaxy Note 7 (disaster), and survey responses indicating which iPhone model consumers are looking to buy.
Furthermore, we're entering into Apple Inc.'s (NASDAQ:AAPL) most volatile season, which will force us to be conscious of timing entries and protect the downside.
Through conversations with investors, Simona Jankowski from Goldman Sachs mentioned that buy side managers are now shifting to a thesis of a two-phase megacycle, which also happens to be my thought process so far.
Rod Hall from J.P.Morgan mentions in his most recent report that mix-shift to the phablet version will have a limited financial impact, and promotional activity in China is mostly limited to China Unicom. That being the case, Rod Hall is on the more conservative end of the spectrum when compared to the rest of the analyst consensus.
Also Read: Apple Inc. (AAPL) IPhone Sales Look Set To Beat Wall Street Estimates
Knowing the pricing events, patterns and timing
There's uncertainty on unit revenue as the 32 GB model wasn't available at launch. The lower-tier model is expected to launch in October. To further complicate things, the upgrade program for 6S/Plus to iPhone 7/Plus implies heightened demand from early adopters given the very generous $650 credit from all four U.S. telecoms. The promotional activity was less substantial in Asia, but with the Americas composing 42.4% of consolidated revenue, the impact will still be noticeable.
Luca Maestri (CFO) usually provides guidance based on 4-weeks of data. It's estimated that Apple will report its earnings/revenue on Oct. 25th, whereas Apple's fiscal year ends on Sept. 27th. In other words, whenever the CFO makes his projection, he's making it based off of 4-weeks of historical data, plus his assumption on what the next 8-weeks will look like.
He's got another month of actual data ahead of the consensus, which is why analysts often defer to CFO's outlook. In fact, the consensus range tends to hover near the outlook provided by CFO at most publicly traded companies, but it's in my view that the predictive value of Apple's outlook has become less meaningful.
According to UBS analyst Steven Milunovich:
The UBS Asia tech team's latest estimates show iPhone 7 procurement plans for F17 have increased from 80mn to 89mn, mainly due to 7 Plus needs. This figure is higher than the iPhone 6s procurement of 87mn but lower than the 93mn for the iPhone 6, which fits with our thesis.
Given the mid-quarter shift in iPhone builds, it's likely that Maestri's estimate won't be as precise, as it's difficult to predict production ramp ahead of better than anticipated demand. In other words, Apple's CFO may be sitting on enough data to make an aggressive projection, but given their historical tendency of conservatism ahead of major quarters, it's in my view that the outlook figure won't provide as much predictive value.
The situation is a little too unique even for one of the world's most intelligent CFOs.
Uncertainty in Q1'17 figures is embedded into a lot of buy-side models. The next two quarterly earnings calls have become much more actionable.
If I'm right, the outlook is conservative but above Q4'16 consensus which will drive the share price higher after the announcement.
But, when we roll around into January, the consensus will utilize channel checks to arrive at figures in-line with actual figures of appx. 4 to 6 weeks prior to the reported earnings date.
Therefore, buy-side managers (who have access to this data) will likely bid the stock after Q4'16 results are announced, and prior to the announcement of Q1'17. Therefore, the rally will likely sustain for a concentrated period of time before consolidating in mid-winter.
This implies that investors who are looking for the most optimal cost basis should be overweight (maintain higher portfolio weightings of Apple) in the months of September through December, and then shift allocations to a more normalized weighting (in-line with risk objectives of course) in the weeks leading up to the mid-point of January.
The stock will likely move in this directional pattern as information is priced into the stock at key points of the earnings cycle. Keep in mind that timing of new information has stayed fairly consistent, but outcomes tend to vary.
Also Read: Is Apple Inc. (AAPL) Likely To Face Serious Margin Pressure?
iPhone ASPs (average selling price) remain the biggest variable
As I have mentioned in the introductory paragraph, there are a lot of moving parts to iPhone ASPs. I have yet to put together a WARP (weighted average retail price) model, so this is more supplementary commentary.
Wamsi Mohan from Bank of America Merrill Lynch takes on the challenge of predicting pricing:
We consider various ASPs and Gross Margins for the iPhone 7/7 Plus. The mix of phones sold (screen size, capacity) will determine the exact ASP and gross margin. We assume an average ASP of $767, and Gross Margin of 43.8% based on the mix of iPhones shown in Figure 3. We then vary the ASP higher and lower, as well as the GM in order to determine impact to ASP.
Keep in mind that the ASP assumption is inclusive of only the 7/Plus in Mohan's quote. His ASP including lower-end models is currently $640 for FY'17.
Apple has consistently revised orders higher, which goes back to the corollary of Apple's CFO guiding conservatively. Apple burned a lot of inventory going into Q4'16, so Apple's lack of production implies more upside to production. It's worth noting that Apple's supply chain isn't as flexible due to the new waterproofing feature.
Survey data from PiperJaffray from their launch day survey implies 54%/46% are buying iPhone 7/7 Plus respectively. Keep in mind, Mohan from BofAML is anticipating 60%/40% for iPhone 7/7 Plus respectively, so Mohan's ASP assumptions could prove conservative.
Kulbinder Garcha from Credit Suisse, on the other hand, is anticipating blended ASPs (including prior/current) at $661 (much higher than Mohan). Garcha is near in-line with the consensus view on his shipment/revenue estimate for FY'17, as he's still anticipating 2018 (super-cycle), which is why he's conservative on shipments.
Final thoughts
I'm taking on the view that the super-refresh is already occurring and is spread between FY'17 and FY'18 with ASPs likely in the $650 to $660 range. As such, we're walking into a blowout quarter, assuming shipments grow high-single digits, and ASPs increase mid-single digits. In that scenario, iPhone revenue grows 14.45% y/y. Investors are likely embedding 10%+ y/y revenue growth in the iPhone segment.
Why isn't anyone else making extremely bullish calls?
Well, let's rewind back to last year when analysts (including myself) got too excited and the actual reality proved to be much worse. Apple's ship went diving… talk about some future tech. The passengers/investors on board plummeted far below the surface… before making it back up.
For now, it seems safe enough to buy a ticket aboard the Apple express, but keep in mind that investor risk appetite limits multiple expansion given historical volatility.
I continue to reiterate my high conviction buy recommendation for Apple stock.


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VetRide is an organization dedicated through cycling to the welfare of all service and ex-service personnel of the Australian Defence Forces. At the same time it provides something meaningful older veterans can do for their younger compatriots, consistent with closely held values, given rise to in uniform.
Our endeavours are supported widely by government agencies and by many organizations and people from all walks of life, in partnership with Victorian State Government who are supplying the major financial support for the event, to the Prime Minister who has provided a message of support (click here), and we operate under the auspices of the Vietnam Veterans Association of Australia (Victorian Branch).
We conduct an annual ride event, the Bass Coast Beach and Bike being planned for 2017.
VetRide Kilcunda 2017 – Bass Coast Beach and Bike – ride starts Thursday 2nd March 2017 and ends Monday 6th March 2017. The ride will be based in Kilcunda and utilise the Bass Coast Hills and Rail Trail.
Preference will be given to service and ex-service personnel, however the event is open to any rider who would like to support our worthwhile cause.
Further details can be located via our menu or click here.
Peter Liefman
VetRide Group Chair