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It was a fistfight with my x wife's boyfriend. I was dropping off my x wife and all her stuff at his house. He took oppeerunity too confront me and a few punches later he had a broken jaw. He claimed his doc bills totaled 30,000 . His bills were payed by victims res fund.
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Innate signaling by the C-type lectin DC-SIGN dictates immune responses
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Effective immune responses depend on the recognition of pathogens by dendritic cells (DCs) through pattern recognition receptors (PRRs). These receptors induce specific signaling pathways that lead to the induction of immune responses against the pathogens. It is becoming evident that C-type lectins are also important PRRs. In particular, the C-type lectin DC-SIGN has emerged as a key player in the induction of immune responses against numerous pathogens by modulating TLR-induced activation. Recent reports have begun to elucidate the molecular mechanisms underlying these immune responses. Upon pathogen binding, DC-SIGN induces an intracellular signaling pathway with a central role for the serine/threonine kinase Raf-1. For several pathogens that interact with DC-SIGN, including Mycobacterium tuberculosis and HIV-1, Raf-1 activation leads to acetylation of NF-κB subunit p65, which induces specific gene transcription profiles. In addition, other DC-SIGN-ligands induce different signaling pathways downstream of Raf-1, indicating that DC-SIGN-signaling is tailored to the pathogen. In this review we will discuss in detail the current knowledge about DC-SIGN signaling and its implications on immunity.
KeywordsC-type lectin DC-SIGN HIV-1 Innate signaling Mycobacteria Raf-1
Effective immune responses depend on the recognition of pathogens by dendritic cells (DCs) through pattern recognition receptors (PRRs) [23]. These PRRs recognize so-called pattern associated molecular patterns (PAMPs), which are conserved groups of molecules from pathogens that are essential for microbial survival, such as bacterial or fungal cell wall components and viral or bacterial nucleic acids [23]. DCs are equipped with several different classes of PPRs that recognize distinct PAMPs expressed by pathogens. These different classes of PRRs include the Toll-like receptors (TLRs), NOD-like family receptors and CARD helicases. Activation of these receptors induces receptor-specific intracellular signals that regulate the expression of response genes, such as those encoding co-stimulatory molecules and cytokines and chemokines.
Most pathogens express different PAMPs and trigger several classes of PRRs on a single cell simultaneously. As a result, the ultimate expression of response genes induced by a pathogen depends on the integration of these different signaling pathways. In fact, cross-talk between or even within groups of PRRs is crucial in balancing immune responses through collaborative induction of positive or negative feedback mechanisms [27].
In recent years C-type lectins have emerged as PRRs that play key roles in the induction of immune responses against numerous pathogens. The C-type lectins DC-specific ICAM-3 grabbing non-integrin (DC-SIGN) and DC-associated C-type lectin-1 (Dectin-1) both shape immune responses against various pathogens. The intracellular signaling pathways induced by these C-type lectins modulate the responses of other PRRs such as TLRs, but also exert functions independent from other PRRs [45].
DC-SIGN interacts with numerous different pathogens including (myco)bacteria, fungi, and viruses. Although the interaction of DC-SIGN with pathogens significantly affects the induction of immune responses [44], the molecular mechanisms that underlie DC-SIGN functions have remained elusive for years. Recently, several studies have shed light on the intracellular signaling pathways through which DC-SIGN shapes immune responses [18, 21, 22]. In this review we will discuss DC-SIGN signaling, with a major role for the mechanism of cross-talk between DC-SIGN and TLRs.
Immunomodulation by DC-SIGN
DC-SIGN is a calcium-dependent carbohydrate-binding protein expressed by DCs [15] and macrophage subpopulations [17] with a wide range of immunological functions. DC-SIGN acts as an adhesion receptor that interacts with ICAM-2 on endothelial cells to induce tethering and trans-endothelial migration of DCs [12] and mediates clustering of DCs with naive T cells through binding of ICAM-3 [15]. In addition, DC-SIGN functions as a PRR that induces specific immune responses upon interaction with numerous pathogens [44]. DC-SIGN binds distinct carbohydrate structures such as mannose-containing glycoconjugates [30] and fucose-containing blood-group antigens [1]. This carbohydrate recognition pattern is the basis of its broad specificity for different pathogens and might also be responsible for its distinct signaling properties.
Mycobacteria target DC-SIGN to affect TLR4-mediated immune responses by impairing DC-maturation and enhancing IL-10 production [14]. Similarly, DC-SIGN binding to the Lewis antigens on LPS from Helicobacter pylori induces IL-10 production but inhibits Th1 polarization [3]. In contrast, LPS from Neisseria meningitidis mutants skews T cells toward a Th1 response by binding to DC-SIGN [41]. In addition, DC-SIGN binding by specific Lactobacilli species induces regulatory T cell differentiation [40]. As binding of DC-SIGN by different pathogens results in distinct immunological outcomes, these findings support an important role for DC-SIGN as an immunomodulator.
Several mechanisms have been suggested to account for the observed modulation of TLR activation by DC-SIGN. Co-localization of DC-SIGN with TLR4 could result in enhanced TLR4 signaling, as has been described previously for SIGNR1, a murine homolog of DC-SIGN [31]. In contrast, DC-SIGN has been hypothesized to induce intracellular signaling itself that converges with signaling pathways of other PRRs.
Recent studies on the interaction of mycobacteria with DCs have shed some light on the molecular mechanisms that underlie DC-SIGN-mediated immune responses. Mycobacteria such as Mycobacterium tuberculosis interact with DCs through various receptors, including TLRs and C-type lectins. TLR-triggering by mycobacteria induces DC maturation and the induction of specific cytokines. However, in addition to TLRs, mycobacteria also interact with DCs by binding to DC-SIGN. One of the main ligands responsible for mycobacterial binding to DC-SIGN is ManLAM [14], a cell wall component abundantly expressed by pathogenic mycobacterial species such as M. tuberculosis. The interaction of ManLAM with DC-SIGN increases the production of the immunosuppressive cytokine IL-10 [14]. By screening with a large panel of inhibitors [18], it was found that upon binding of ManLAM, DC-SIGN triggers an intracellular signaling cascade independent from other PRRs. Pivotal to DC-SIGN-signaling is the activation of serine/threonine kinase Raf-1. Ligand binding leads to activation of Raf-1 and inhibition of Raf-1 completely blocks DC-SIGN-mediated immune responses to mycobacteria. In the next paragraphs, we will discuss DC-SIGN signaling in detail. For clarity, we will first focus on the upstream signal transduction pathways that lead to Raf-1 activation; subsequently, we will discuss DC-SIGN signaling downstream of Raf-1 and how this leads to modulation of immune responses.
DC-SIGN signaling upstream of Raf-1
How binding of ManLAM or other ligands to DC-SIGN leads to the initiation of intracellular signaling is still unclear. DC-SIGN displays several motifs in its cytoplasmic tail that theoretically could be involved in the induction of intracellular signaling pathways. Two motifs, a di-leucine-based motif and a tri-acidic (Glu–Glu–Glu) cluster, are known to be required for internalization [8]. In addition, DC-SIGN bears a YxxL motif in its cytoplasmic tail, which is known to be required for signaling of two other C-type lectins, Dectin-1 and CLEC-2 [9, 11, 35]. However, although it could play a role in the induction of other intracellular signals [21], the tyrosine motif of DC-SIGN is not essential for the activation of Raf-1 [18]. In addition, both the tyrosine and the di-leucine motif are required for the association of the cytoplasmic tail of DC-SIGN with leukocyte specific protein 1 (LSP1), an F-actin binding protein [39]. However, LSP1 has not been established to play a role in signaling, but has been shown to mediate DC-SIGN-dependent transport of HIV-1 to proteasomes [39]. Clustering of DC-SIGN-molecules could also play an important role in the induction of intracellular signals. DC-SIGN forms tetramers [30], which might allow the binding of adaptor-molecules that can bridge the cytoplasmic tails of two or more DC-SIGN molecules, as has been hypothesized for Dectin-1 signaling [35]. Taken together, the mechanism of how ligand-binding leads to the induction of signal transduction is still highly speculative.
Thus, DC-SIGN induces the activation of three routes that converge to activate Raf-1 (Fig. 1): activation of Ras leads to binding to Raf-1 and induces conformational changes that allow for subsequent phosphorylation of Raf-1 by Src and Pak kinases; Src kinases induce the phosphorylation of Raf-1 at residue Tyr340/341, whereas Rho GTPase-dependent activation of Pak kinases results in phosphorylation of Raf-1 at Ser338.
DC-SIGN signaling downstream of Raf-1
As described above, activation of Raf-1 is essential for DC-SIGN-mediated immune responses. However, signaling downstream of Raf-1 appears to be dependent on the specific DC-SIGN-ligand involved. For example, DC-SIGN activation by a specific antibody denoted MR-1 results in activation of extracellular signal-regulated kinase (ERK) [5]. Although mitogen-activated protein kinase kinase (MEK), which can activate ERK [25], is a well-characterized possible downstream effector of Raf-1, it is unclear whether MR-1 also activates Raf-1. In addition, some studies have shown that a C-type lectin interaction with HIV-1 [37] or a glycoprotein allergen [38] induces ERK activation, although direct involvement of DC-SIGN has not been demonstrated in these studies. In contrast, other reports have demonstrated that binding of pathogenic ligands to DC-SIGN does not lead to activation of ERK [18, 22]. Hence, ERK activation might be dependent on the ligand binding to DC-SIGN, although certain contaminants in the ligand preparations might also explain some of these differential effects. Nevertheless, for most pathogens including M. tuberculosis and HIV-1, interaction with DC-SIGN modulates immune responses by targeting nuclear factor-κB (NF-κB). An exception is DC-SIGN-ligand Salp15, which will be discussed separately in a paragraph below.
NF-κB activation is crucial for the induction of DC-mediated immune responses [32]. The NF-κB family is composed of several subunits that can form homodimers and heterodimers. The most abundant and prototypical form of NF-κB is a heterodimer between p65 and p50, of which p65 is the transcriptionally active component. In unstimulated cells, p65 is inactive and resides primarily in the cytosol in complex with any of the inhibitory IκB proteins. Upon stimulation, the IκB proteins are degraded and the p65–p50 dimers translocate into the nucleus where they bind to target DNA sequences to influence gene expression. Several classes of PRRs induce the activation of NF-κB after pathogen recognition. For example, TLR triggering leads to p65 activation via both MyD88- and TRIF-dependent pathways [42], which induces the transcription of numerous target genes including cytokines and chemokines.
The activity of p65 is regulated by several post-translational modifications such as phosphorylation and acetylation [20]. Strikingly, DC-SIGN-signaling controls p65 activity by phosphorylation of p65 at serine 276 (Ser276), which is completely dependent on Raf-1-activation [18]. Subsequently, phosphorylation of p65 at Ser276 leads to acetylation of p65. Acetylation of p65 can be mediated by two histone acetyltransferases (HATs), CREB binding protein (CBP) and p300, which in human DCs show high constitutive activity (unpublished data). Acetylation is known to have major consequences for p65 activity [20]. DC-SIGN-mediated acetylation of p65 leads to both increased and prolonged transcription from the IL10 promoter, resulting in a strongly increased production of IL-10 by DCs [18].
Crucial for the understanding of DC-SIGN-signaling and its effect on immune responses is that DC-SIGN cannot activate p65 by itself, but can only modulate p65-activity when activation of p65 has been induced by another receptor. The induction of DC-SIGN-signaling by the mycobacterial component ManLAM does not induce activation of p65, and therefore does not induce any cytokine responses. However, upon stimulation with whole mycobacteria, TLR4 and TLR2 triggering induce the activation and translocation of p65 to the nucleus, which allows for subsequent phosphorylation and acetylation of p65 by DC-SIGN signaling (Fig. 1).
A question that remains unanswered is the identity of the kinase responsible for phosphorylation of Ser276 of p65 upon DC-SIGN triggering. A number of kinases have previously been reported to phosphorylate Ser276 on p65, including protein kinase A (PKA) and the related mitogen- and stress-activated kinase-1 (MSK1) [47, 49], but inhibitors against these kinases do not inhibit ManLAM-induced IL-10 upregulation [18]. Hence, the identity of this kinase is still under investigation.
DC-SIGN-mediated modulation of immune responses to pathogens
In addition to several mycobacterial species including M. tuberculosis, M. bovis BCG and M. leprae, DC-SIGN-signaling is induced by several other classes of pathogens. Yeasts (Candida albicans and Saccharomyces cerevisiae) and viruses (HIV-1 and measles virus) also induce the Raf-1 pathway through DC-SIGN to modulate TLR responses [18]. This underscores that DC-SIGN has an important role in the regulation of DC-mediated immune responses to numerous pathogens. As mentioned before, immune modulation of NF-κB activation only occurs when a pathogen triggers DC-SIGN simultaneously with another receptor that activates NF-κB. For example, mycobacteria such as M. tuberculosis and M. bovis BCG activate NF-κB through TLR2 and TLR4 activation, while viruses activate NF-κB via TLR3 and TLR7/8 triggering in endosomes [6]. However, the modulation of immune responses by DC-SIGN is probably not restricted to TLR-activation, but instead might also include other NF-κB dependent responses. Hypothetically, DC-SIGN signaling modulates the induction of any immune response that is p65-dependent, since phosphorylation and acetylation of p65 drastically alter the transcription rate, the duration of p65 activation and even the affinity of p65 with other proteins [20].
Additional investigations are required to determine how DC-SIGN signaling affects the immune response against a specific pathogen in toto. Besides the immunosuppressive cytokine IL-10, acetylation of p65 most likely modulates the transcription of other, pro-inflammatory immune genes as well, since the majority of cytokines induced by TLR-stimulation in DCs depends at some level on NF-κB activation. Therefore, the resulting net immune response induced by DC-SIGN-signaling depends on the complete array of cytokines that are modulated by p65-acetylation. Future investigations will be required to determine whether DC-SIGN-signaling dictates pro- or anti-inflammatory responses or whether it directs a specific type of T cell differentiation such as T helper 1, 2, 17 or regulatory T cells.
Immunomodulation by salivary tick protein Salp15
While interaction with the previously described mycobacteria, viruses and fungi with DC-SIGN leads to Raf-1-dependent acetylation of NF-κB, interaction of another DC-SIGN-ligand, Salp15, modulates TLR-activation on DCs through a different mechanism. Salp15 is an immunomodulatory protein produced by the salivary glands of Ixodes scapularis ticks [7]. The presence of immunosuppressive molecules in tick saliva facilitate tick feeding, but also greatly enhance the tick's ability to transmit human pathogens such as Borrelia burgdorferi [33], the causative agent of Lyme disease.
The reason behind the different downstream effectors of Raf-1 after activation by Salp15 compared to ManLAM is still unclear. One explanation could be that Salp15 also activates other receptors, which modulate DC-SIGN signaling. Besides DC-SIGN, Salp15 has also been described to bind to CD4 [24]. Although no direct physical association has been found between both proteins [4], DC-SIGN and CD4 have been found to colocalize on the cell-surface [26]. On T cells, binding of Salp15 to CD4 modulates actin polymerization [24]. A central theme in signaling is bringing together kinases and substrates, and impairment of actin polymerization might bring Raf-1 together with a different downstream effector compared to ManLAM-induced DC-SIGN-signaling. Therefore, co-ligation of DC-SIGN and CD4 by Salp15 might be responsible for the induction of this distinct signaling pathway by affecting the subcellular localization of either Raf-1 or its downstream effectors. Additionally, future research on the molecular mechanism of Salp15-induced DC immunosuppression is required to elucidate how MEK affects mRNA stability and nucleosome remodeling. Although MEK kinases are well known to activate ERK 1 and 2, Salp15 does not signal through ERK kinases [22]. The downstream effectors of MEK are most likely involved in post-translational modifications of the proteins involved in mRNA decay and nucleosome remodeling.
Thus, although Salp15 binding to DC-SIGN does induce Raf-1 activation similar to ManLAM, the downstream effectors that modulate TLR-induced activation are different. This demonstrates that pathogen binding to DC-SIGN might lead to different ligand-specific signaling cascades that regulate distinct adaptive immune responses. Although Raf-1 seems to play a central role in DC-SIGN-induced modulation of TLR-responses, the downstream effectors of Raf-1 regulate the subsequent cytokine responses.
Immune suppression and viral transmission by HIV-1
As described previously, binding of HIV-1 to DC-SIGN modulates TLR activation via Raf-1 signaling [18]. However, DC-SIGN signaling by HIV-1 not only enhances TLR-induced IL-10 production, but also impairs TLR-induced dendrite formation of DCs and T cell proliferation [21]. In addition, HIV-1-induced DC-SIGN signaling mediates effects independent of TLR activation. Microarray studies revealed that cross-linking of DC-SIGN with an antibody that mimics HIV-1-binding specifically affected the gene expression profile of DCs, with hundreds of genes being induced or downregulated after ligation [21]. One of the most notable features of the DC-SIGN signaling program is the induction of ATF3, a negative regulator of TLR4 [16], suggesting that DC-SIGN signaling besides modulating also represses TLR4 signaling.
Besides modulation of immune responses, DC-SIGN signaling also plays an important role in the transmission of viruses from DCs to T cells [13]. DCs capture HIV-1 through the high-affinity interaction of DC-SIGN with gp120, the HIV-1 envelope glycoprotein. Subsequently, DCs are able to mediate transmission of the virus to T cells through the formation of a so-called infectious synapse between HIV-1-infected DCs and CD4+ T cells [29]. Recently, Hodges et al. [21] demonstrated that DC-SIGN-induced signaling is responsible for viral synapse formation between DCs and T cells. The authors found that binding of HIV-1 to DC-SIGN on DCs induces LARG-mediated activation of the GTPase RhoA, which is required for viral synapse formation. It will be interesting to investigate whether RhoA activation by HIV-1 is also involved in the Raf-1-dependent immune responses (Fig. 1). Taken together, these findings suggest that the DC-SIGN signaling pathway orchestrates several immunological functions of DCs ranging from modulation of immune responses to the transmission of viruses to T cells.
DC-SIGN signaling in context of other C-type lectins
The C-type lectin receptor family has been increasingly appreciated as an important member of PRRs. However, although most C-type lectins express several potential signaling motifs in their cytoplasmic domains, the molecular mechanisms underlying the C-type lectin functions are still largely unknown. The current knowledge about the molecular mechanisms of C-type lectins seems to suggest that the different receptors induce distinct signaling pathways. Recently, several studies have characterized the signaling pathways of Dectin-1, a C-type lectin involved in innate immune responses to fungal pathogens. Engagement of Dectin-1 by fungal β-glucans leads to activation of spleen tyrosine kinase (Syk) [35], which is also induced upon ligation of CLEC-2 [9], but not DC-SIGN [9, 18]. Subsequently, Syk activation by Dectin-1 induces caspase recruitment domain 9 (Card9)-dependent activation of NF-κB [19] (for an extensive review on the mechanism of Dectin-1 signaling see [34]). As a consequence the activation of Dectin-1, in contrast to DC-SIGN signaling, directly leads to the expression of cytokines independent from TLR activation.
However, DC-SIGN and Dectin-1 also mediate similar functions. Analogous to DC-SIGN, Dectin-1 collaborates with TLRs for the induction of cytokines [10]. The signaling pathway underlying this cross-talk between Dectin-1 and TLRs remains to be identified, but seems to be independent of Syk [10, 35]. Since DC-SIGN and Dectin-1 bear common motifs in their cytoplasmic tail, this could suggest that Dectin-1 might use similar signaling pathways for the modulation of TLR responses. In addition, a recent study reported that both Dectin-1 and DC-SIGN mediate the induction of arachidonic acid [43]. Moreover, Dectin-1 was found to associate with DC-SIGN, which was enhanced upon stimulation with zymosan, a ligand for both Dectin-1 and DC-SIGN [43]. Since DC-SIGN and Dectin-1 are both involved in the recognition of pathogens such as C. albicans, co-localization of these two C-type lectins might add additional variability to both DC-SIGN- and Dectin-1-induced signaling cascades.
DC-SIGN signaling: beneficial for host or pathogen?
DC-SIGN-signaling by pathogens does not modulate immune responses in the same manner, but instead the immune modulation depends on the pathogen involved. These differences most likely result from the specific set of PRRs that is activated. Every type of pathogen triggers a specific set of PRRs, which are modulated differently by DC-SIGN signaling. In addition, DC-SIGN itself might induce different signaling pathways depending on the DC-SIGN ligand involved. However, a pivotal question that remains is whether the DC-SIGN-induced modulation of immune responses is beneficial for the host or whether DC-SIGN signaling is induced by pathogens to subvert an effective immune response and promote their growth and survival.
In the case of HIV-1, DC-SIGN signaling appears to be unambiguously beneficial for the pathogen. DC-SIGN signaling by HIV-1 impairs DC maturation, T cell proliferation and mediates the transmission of HIV-1 to T cells, thereby promoting systemic infection of the host. In addition, for mycobacteria DC-SIGN signaling was initially thought to be a mechanism through which DC function was suppressed to promote pathogen survival, based on impaired DC maturation and enhanced production of the immunosuppressive cytokine IL-10 by DCs after stimulation with ManLAM. However, this suppression might also be beneficial to the host by preventing excessive immune activation. So far, genetic epidemiology has yielded conflicting data. A recent study suggested that a single nucleotide polymorphism (SNP) that leads to decreased DC-SIGN expression is associated with reduced risk for cavitary tuberculosis disease [46]; in contrast, SNPs in the DC-SIGN promoter region that lead to increased DC-SIGN expression appear to be protective against tuberculosis [2]. In addition, in a recent study it was reported that transgenic mice expressing human DC-SIGN actually show enhanced clearance of mycobacteria [36]. DCs from DC-SIGN-mice displayed reduced tissue damage and prolonged survival. These findings suggest that instead of favoring the immune evasion of bacteria, DC-SIGN signaling may promote protection by limiting tuberculosis-induced pathology. However, remarkably, most DC-SIGN-binding pathogens are microbes that in general induce latent infections, such as M. tuberculosis, M. leprae, C. albicans and H. pylori. This suggests that suppression of the immune response via interaction with DC-SIGN results in a "steady-state" that attenuates immune-activation in order to limit detrimental side effects of a full-blown immune response, but in turn also allows for pathogen survival.
We would like to thank M. A. W. P. de Jong and M. van der Vlist for critically reading the manuscript and helping with the illustrations. J. d. D. is supported by grants from the Dutch Scientific Research program (NWO 912-04-025). SIG is supported by the Dutch Asthma Foundation (3.2.03.39).
Open Access
This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.

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Center for Economic Forecasting and Development
The UCR Center for Economic Forecasting and Development at the School of Business Administration is a major new initiative for economic research and the first world class university forecasting center in Inland Southern California. The Center creates economic forecasts and economic development products that expand understanding of one of the state's most vital growth areas. By serving as a hub of collaboration, the Center is a place where innovative development ideas and strategies emerge from both researchers and business and government leaders.
Appearances & Events
- View the PowerPoint slides and the complete Forecast Report delivered at our recent 7th Annual Inland Empire Economic Forecast Conference.
- U.S. & California Forecast - Christopher Thornberg
- Inland Empire Forecast - Robert Kleinhenz
- Inland Empire 2035 Long Range Forecast- Christopher Thornberg
- 2016 Inland Empire Economic Forecast Conference Book
- Director Christopher Thornberg recently joined a UCR-led delegation to Taiwan as part of an effort to identify joint research opportunities and establish closer connections with universities and businesses in that country. View the PowerPoint.
- At a meeting of San Bernardino County's Chief Business Officials, Executive Director of Research Robert Kleinhenz delivered a new economic outlook for the state and Inland Empire region. View the PowerPoint.
- Director Christopher Thornberg delivered his latest forecast for the U.S., California, and Inland Empire economies at a recent retreat hosted by Universal Health Services. View the PowerPoint.


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Title: Candle and Figurines Jigsaw Puzzle
About: Another Christmas themed puzzle is here! In this new one we feature a holiday themed candle (decorated with a snowman and Christmas tree) and two figurines (one holding a present) in a winter holiday decor.
Puzzle of the day on: 15-Dec-2015
Image Credit: Public Domain
Copy/Paste the HTML code below to link to this puzzle from your website or blog.


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Box personal storage app for iOS updated, offers free lifetime 50 GB storage to new users
This entry was posted on Sunday, January 19, 2014.
The personal cloud storage business is fairly competitive, but Dropbox seems to have the greatest mindshare of all the services which provide it. The standard system is this: you get around a couple of GBs for free, where you can store a certain number of files, and to get any excess amount of either, you need to pay up. Box, one of the other more famous cloud storage solutions, may be turning that on its head, as it is offering new Box users 50 GB of storage that will be free for a lifetime for downloading their new and updated iOS app. Read on below the break to know more.
The Box app has been updated to follow Apple's iOS 7 design guidelines, with a flat UI and no skeumorphism, among other things. Clearly, they have done a commendable job in that regard as the new app is rather impressive. However, the true purpose of an app like that is in its functionality and the Box app is flawless in practically every way, as is typical for it across all platforms.
Of course, this isn't the first time Box has actually done this. Box had a long running collaboration with Android OEMs Sony and HTC to give new buyers of those two companies' phones the same 50 GB lifetime storage option, and it seems to be extending the benefit to new users as well.
You can download the new Box app for iOS from the App Store here.


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Events in Durban CentralWhisky Live Festival Durban
Please Note
This event has already taken place. All details published in good faith, as supplied by the organisers. Please check our current and upcoming events list for events to attend.
Where? Durban
When? 24-25 April 2015
Overnight? See Durban Central accommodation, in KwaZulu Natal
Building on its reputation as the largest, liveliest and most exciting whisky lifestyle show of its kind in the world, the FNB Whisky Live Festival showcases over 180 local and international established whisky brands, new whiskies being launched into the South African market and an eclectic mix of whisky lifestyle premium products.
Whether you're a beginner in the world of whisky, or a long time whisky connoisseur with the most discerning of palates, the organisers promise that the festival will offer something for everyone over 18. Learn more about whisky while networking with like-minded whisky lovers, during a fun and interactive night out. The festival offers whisky workshops, the Whisky Lifestyle Lounge (which is ideal for meeting friends or entertaining clients), the hugely popular Connoisseur's Experience as well as a host of new education zones, which all demonstrate whisky's versatility.
There is so much more to discover at this year's FNB Whisky Live Festival than ever before.
A variety of ticket options will be available for purchase.
Venue: Durban International Convention Centre
Time: Daily from 18h00 to 22h00


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Pocahontas Matoaka
Jaydah Howell & Natalie Orebaugh
Born: 1595 - 1617
Pocahontas was in the Algonquian Tribe in the Tidewater region of Virginia. She was the daughter of Chief Powhatan also known as the Indian princess. She saved John Smith in 1607 from death. She married John Rolfe in January 1615. They had a son named Thomas Rolfe. Pocahontas's marriage to John Rolfe was the first record interracial marriage in american history. In 1616 the Rolfes traveled to London.Pocahontas was her nickname and it translated to "little wanton." She wore a leather mini-dress with one shoulder strap. She had a tattoo. She died in Gravesend, England. Pocahontas was a important person in american history.


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Is PA Virtual Right for You?
Enrollment FAQ
Below are some of the most frequently asked enrollment questions about PA Virtual. However, these FAQs are no substitute for personal answers to your individual questions. Please contact us to learn more about PA Virtual at 866-728-2751. Enroll now to secure your seat for the Fall!
Please note that students should stay enrolled and attending at their current school while completing the enrollment process with PA Virtual.
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Complete your online application, making sure to submit the documents you have prepared. Once we receive your application, we'll contact you to walk you through the enrollment process and to request any missing documents.
After all of your documents have been received, your Enrollment Placement Teacher will call to schedule an Enrollment Conference for you and your child.
At the Enrollment Conference, you'll meet with your Enrollment Placement Teacher, get detailed information about your grade level and responsibilities, complete final paperwork, and confirm your start date. Your child should stay enrolled at his or her current school until a withdrawal date is determined at the conference.
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For 14 years I have worn a wig of some kind. I was told by many dermatologist that because of the damage I had done to my hair wearing weaves that there was no chance of it growing back.
Of course like many women I was crushed because society teaches us that hair is apart of our beauty and to be loved or to be seen you must have hair.
Jumping ahead, the last 6 years were like a battle ground between the real me waiting to come out and the me that has lived under the thumb of society for so long.
Being married with kids and thinking that I will have the support of my family I decided to discuss with them my desire to go bald.
B.A.L.D.= Beautiful, Awesome, Lavish, Diva
Boy, if you could have seen the look on my face when I heard the things that come out of the mouths of my support team o-:.
I mean the concerns were more about them then it was for me which made my battle even harder.
Then one day I did it. I cut the hair all off and took it to the streets. Needless to say, it was the most uncomfortable feeling ever.
People were looking at me as if I was sick. This didn't make me feel any better so I went back to the wigs.
That was 4 years ago and on August 14, 2012 my battle came to an end.
I was getting dress for work and I grabbed my wig and placed it on my head.
I was so frustrated with styling it and trying to curly it that I just walked out the house and grabbed the brush.
As I was driving I snatched the wig off and said this is it, I can't take this any more.
I put my make-up on and walked into my office all natural and have been going strong ever since.


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One of the few monarchies left in Africa, this tiny country is a fascinating cultural destination with a number of interesting destinations and festivals, most notably the Umhlanga, or Reed Festival and the Ncwala, or Kingship Festival.
Swaziland is renowned for its fantastic crafts, and you will find an enormous range of unique and sophisticated items for sale at the numerous craft centres. Swaziland�s main industries are sugar, forestry and tourism but the country has an interesting history of mining. Gold was mined in the north near Piggs Peak, and the world�s oldest known iron mine, which only stopped production late in the 20th Century, is in Swaziland.
But it�s also a fantastic wildlife, nature and adventure destination. There is a surprising diversity of climatic and vegetation zones for such a tiny country. It�s divided into the Highveld, the Middleveld, the Lowveld and Lebombo, and also into four provinces, Hhohho, Mbabane, Shiselweni and Lubombo, that do not correspond with the climatic regions. The Highveld in the north-west is relatively cool, with beautiful rolling hills covered in Afromontane grassland with pockets of forest in the kloofs, and the Lowveld is typical subtropical broad-leafed bush. The Middleveld, not surprisingly, is somewhere in between. The Lebombo Mountains, on the eastern edge of the country adjacent to the Mozambique border, are an ancient volcanic range covered in coastal thicket and forested kloofs.
Swaziland�s main game-viewing areas are the Hlane Royal National Park and Mkhaya in the Lowveld, where you are likely to see the usual big animals most people associate with an African safari. Rhinos, elephants and other animals roam the bush in both reserves, and there are lions at Hlane. And there are also smaller animals to be seen at Malalotja, Mlilwane and Mlawula.
With its large population of black and white rhino, Swaziland used to have a big poaching problem, but it has introduced some very stringent legislation. Poaching carries a mandatory minimum sentence of five years and � here�s the best part � trafficking carries seven. So don�t even think about it.


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Another day, another photoshoot from Toke Makinwa– just that it is very risque this time.
The media personality took to her Instagram to share a bra-less photo of her — showing off her boobs in a see through tank top.
This racy shoot is quite surprising cos all her shoot are pretty tame. Perhaps she feel it is time for a 'mature' shoot.
Well she has to prepare herself for some bashings from the sanctimonious Nigerian community– who would be riled up upon seeing the racy photo.
"BOLD. BARE. STRONG. SEXY. POWER. FREE. This year has been one of transformation, transition and evolvement. I am BECOMING??? so excited about what's to come…," she wrote in the caption of the snap.
Make Money Online in Nigeria... Click HERE To Start Now!


text:
1017 Items15 textbooks were found
List Price:$15.00
Indian self-determination and education assistance act: Hearings before the Subcommittee on Indian Affairs of the Committee on Interior and Insular ... second session, on S. 1017 and related bills
Representation Theory and Complex Analysis: Lectures given at the C.I.M.E. Summer School held in Venice, Italy, June 10-17, 2004 (Lecture Notes in Mathematics / C.I.M.E. Foundation Subseries)RentList Price:$74.95
Probability Theory on Vector Spaces IV: Proceedings of a Conference, held in Lancut, Poland, June 10-17, 1987 (Lecture Notes in Mathematics) (English and French Edition)RentList Price:$59.00
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what is that ancient artifact you're holding?
It's not me in the picture; it's one of my classmates from photography class. In class, we shoot on black and white film.
Love this!!!
Niiiiiiice !
The focus is great
excellent DoF
Hey, you got it to work!
Yeah, pretty much. I'm still waiting to see the ones with you, though.
i love film
i love this picture.
i love this picture.
filmmmmmmmm yo
Nope, not film for this one. I took a couple on film too, though. My teacher had me shoot a digital to see if the lighting would work.


text:
6948 Puustinen Road, Kaleva MI, 49645
Sold Price:
2 beds , 2 Full baths
1,350 sqft
Status: Closed
Last Updated: 7/20/2017 5:41 PM
Description for 6948 Puustinen Road Kaleva, MI 49645
Modern, neat, clean hobby farm in the middle of 'up north'. 2 BR, 2 B home completely remodeled. Kitchen, tile, laminate and carpet. Large Master Bedroom, 3 season porch, 2 stall attached garage with openers. slate floored family room/ office. Ceiling fans, skylights, lovely windows.new 2015 reverse osmosis system in kitchen & new 2015 water heater Re-shingled in 2008, new well head 8/13. Exercise/Yoga room and craft room in basement. Plenty of storage in this home. Horse stable is 24x48, 2 matted 12x12 stalls with dutch doors, plus one additional stall. Overhead fans, storage for 400 bales of hay. Round pen and 66x132 dressage ring. New steel roof in 2012. Pole barn is 32x48 includes a heated/insulated workshop with 220 power and garage door with opener plus 2 10' doors. 2 addition
Sold Price:
Sold Date:07/23/2015
Dickson Twp
2 Full
1,350 (approx)
Listing Information
Dickson Twp
Crawl Space
Softener Rent
Septic, Existing Well
Electric, Telephone
School Information
Room Information
Island, Butler Pantry
Interior Features
Dishwasher, Dryer, Garbage Disposal, Microwave, Convection Oven, Range, Refrigerator, Washer
Laminate, Ceramic
Central Air, Ceiling Fan(s)
Electric Heating, Propane, Wood, Forced Air, Baseboard
Basement, Partial
Insulated, Screened, Skylights
Exterior / Lot Features
Attached Garage, Detached Garage, Unpaved
Deck, Porch
Garden, Sidewalks, Stable, Recreation Facility, Public Roads, Unpaved Road, Wooded, Acreage
Driving Directions
US 31 N to 9 mile (just past Osborn Sport Shop) Turn right - go through Kaleva. Right on Puustinen Rd. (at Big Bear Sports Club Sign) Right on Johnson left on D Lane Right on Puustinen
Financial Considerations
Listing Price History
Kaleva Real Estate
Kaleva is located in Michigan. Kaleva, Michigan 49645 has a population of 464.
The median household income in Kaleva, Michigan 49645 is $40,417. The median household income for the surrounding county is $40,408 compared to the national median of $53,482. The median age of people living in Kaleva 49645 is 46.1 years.
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Treatment & Support
At The Mental Health Association of Westchester, we offer an array of specialized services to help individuals achieve their goals. From outpatient clinic services and services at community locations to family and peer support to Planned Respite and more, contact us to see how we can best assist you.
We offer individual, group, family and medication services for individuals of all ages – and for a full range of behavioral health conditions. Our licensed behavioral health professionals – including social workers, counselors, psychologists and psychiatrists – provide the utmost quality of care through person-centered, recovery-focused services. Treatment decisions, which are made collaboratively between an individual and their therapist, may be enhanced through additional work with trained peer specialists.
To schedule an appointment at a convenient location, please call our Central Intake Scheduler at 914-345-0700, ext. 7350. Contact us for information or to make a referral. Referring providers: please use our Referral Form.
Walk-In Services
Our walk-in services, which do not require an appointment or previous history as an MHA client, benefit individuals who need support in the moment. Walk-in services are generally available Monday through Thursday, from 9:00 am to 4:00 pm in the following locations:
Mt. Kisco: 344 Main Street, Suite 301, 914-666-4646
White Plains: 300 Hamilton Avenue, Suite 201, 914-345-0700
Although no appointment is needed, please phone ahead if possible
First Episode of Psychosis (OnTrackNY@MHA)
For more information, please contact Dr. Stephen Smith at 914-345-0700, ext. 7727 or email@example.com.
Nuestro Futuro - Servicios para La Comunidad Latina
Nuestro Futuro es un programa bilingüe y bicultural que ofrece tratamiento de salud mental a niños mayores de cinco años, adolescentes y adultos en Español.
Libre acceso diariamente en Mount Kisco y White Plains. Lunes a Viernes: Las horas de operación varían dependiendo la localidad.
Comuniquese con Margarita Padilla: firstname.lastname@example.com
Partners in Parenting
Through our home-based Partners in Parenting treatment program, we are able to serve parents who have behavioral health conditions and who have had difficulty utilizing traditional clinic-based treatments. Our recovery-oriented services can help parents create brighter futures by improving decision making and parenting skills, maintaining custody of their children, reducing risk of hospitalization, developing stronger social networks and working toward employment or educational goals.
For more information, please contact Patrice Monaghan at 914-666-4646, ext. 7524 or email@example.com.
Assertive Community Treatment
Referrals are through the Westchester County Department of Community Mental Health at 914-345-5900 ext. 7520. For more information, please contact Paula Stephenson at 914-347-4290, ext. 7535 or firstname.lastname@example.com.
Family Support Services
We are proud to offer one-on-one care, family and peer support groups, advocacy, respite and parent education for families who participate in MHA programs and who have a child who has been diagnosed with a behavioral health condition or behavioral challenge.
For more information, please contact Ruthanne Becker at 914-345-5900, ext. 7510 or email@example.com.
Home Based Therapy
Following a hospital stay for the treatment of a behavioral health or substance abuse condition, members of the Beacon Health Plan may benefit from our Home Based Therapy program, which provides post-discharge assessments in the individual's home or in a community setting. Home Based Therapy also helps individuals assure that plans for follow-up appointments are realistic, confirms that prescriptions for medications have been filled and helps develop plans to prevent and manage potential future crises.
For more information, please contact Patrice Monaghan at 914-666-4646, ext. 7524 or firstname.lastname@example.com
Care Management/Health Homes
Our Care Management services, uniquely tailored to meet the comprehensive needs of each individual, help people become - and remain - healthy while avoiding hospitalization. Care Managers help individuals obtain the services they need, which may include seeing medical specialists, successfully transitioning from an inpatient hospital admission to another setting, and obtaining social supports such as housing. Additional services may include family support and referral to community and social support services.
For more information, please contact Michael Went at 914-345-5900, ext. 7550 or firstname.lastname@example.com.
HARP-HCBS (Home and Community Based Services)
Home and Community Based Services (HCBS) are a new set of recovery-oriented services available to HARP eligible and approved individuals. HCBS services include Empowerment Services-Peer Support, Vocational Services, Educational Services, as well as Community Psychiatric Support and Treatment (CPST), Psychosocial Rehabilitation (PSR), Habilitation, and Family Support and Training. Our full staff are available to meet the needs of each individual's goals towards recovery.
HARP eligible individuals include those who are 21 years or older, are insured by Medicaid managed care, are enrolled in a Health Home and have a Care Manager.
For more information or to request HCBS services, please contact Kathleen Bonistall at 914-345-5900 ext. 7615 or email@example.com
Planned Respite
For more information, please contact Bibi Salim at 914-966-9293 or email@example.com.
Children's Home and Community Based Services/Children's Care Management Services
Our Mobile Mental Health team provides treatment and care management services in the home or other community location for high-risk children between the ages of five and 18 who have behavioral health conditions and have had difficulty benefiting from traditional behavioral health treatments in a clinic setting. Additionally, our Home and Community Based Services Waiver and Intensive Care Management programs provide community-based care coordination services for children ages five to 17 who have behavioral health issues that have led to psychiatric hospitalization or have put the child at risk for an out-of-home placement. Our individualized recovery-oriented services and multi-disciplinary collaborations help children and families obtain needed services and supports.
Referrals for these services are made through Westchester County Children's Single Point of Access process. To make a referral, please download and submit the Universal Referral Form.
For more information, please contact Deirdre Sferrazza at 914-345-5900, ext. 7519 or firstname.lastname@example.com.
Westchester Recovery Network-Intensive and Westchester Recovery Network
The Westchester Recovery Network-Intensive (WRN-I)* is a mobile support service provided by peer professionals to assist individuals who are currently in the hospital or have had a recent hospitalization for a behavioral health condition. We recognize that everyone has their own unique recovery journey and WRN-I views relapses and hospital re-admissions as bumps in the road. WRN-I empowers people to move forward on their path, collaborating with them to honor their inherent strength and resilience.
The Westchester Recovery Network (WRN)** offers peer outreach and support for adults who have experienced behavioral health conditions and wish to decrease dependence on the behavioral health system while developing greater self-reliance and a more fully integrated life in the community. Operated by peer professionals, WRN is made up of Recovery Specialists who have lived experience. They help individuals discover or rediscover their passions in life and establish connections with others, helping to further self-development and economic self-sufficiency.
For more information, please contact Dwayne Mayes, Director for the Recovery Network and Peer Training, at 914-347-4290, ext. 7594 or email@example.com
* The current Westchester Recovery Network-Intensive was formerly known as the Westchester Recovery Network
** The current Westchester Recovery Network was formerly known as the Northern Westchester Recovery Network
Sterling Community Center
Sterling Community Center July Calendar


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Former New York Yankees great Don Mattingly and San Diego Padres bench caoch Ted Simmons, hoping to become major-league managers for the first time in 2011, will manage this winter in the Arizona Fall League.
Mattingly, a bench coach for the Dodgers and the 1985 American League MVP for the Yankees, will manage the Phoenix Desert Dogs. Simmons, an eight-time All-Star manager, will manage the Peoria Saguaros.
The other Arizona Fall League managers are Casey Kopitizke of the Cubs, Randy Knorr of the Nationals, Mike Sarbaugh of the Indians and Mike Guerrero of the Brewers.
By Bob Nightengale
Daily Pitch is a baseball fan's destination for breaking news, emerging trends and enlightening banter. With a veteran group of reporters positioned in three time zones, we provide a balanced, comprehensive glimpse at our national pastime, with a nod to both the passion and complexities that make the sport irresistible to many. More about our reporters


text:
Immunity' "Medallion**BB10 5th November 2016 telly written story|Bb10 6th November Om,Mona Nitibha eliminated
Immunity' "Medallion**BB10 5th November 2016 telly written story|Bb10 6th November Om,Mona Nitibha eliminated
Bigg Boss 10 – 5th November 2016 , BB10 6th November 2016, BB10 5th November written update telly, BB10 full episode download 6th November 2016, BB10 Mona lisa eliminated 6th november, Bigg boss BB10 6 Nov full episode, BB10 full episode day 21 written
Bigg boss 10 (BB10) – 5th November , 6th november 2016 written update full episode written story, watch online the Bigg boss 10 Day 21 ,22 full episodes. In today's episode there was the task for the contestants to put a sign board – Naagin to Nitibha, gunda – malveer, gaurav got total 3 sign boards. In this episode 20 Day 21,22 Monalisa and Nitibha, Swami Omji are nominated for the Eliminations, rest of the house members – Manu punjabi and Manveer got safe by the viewers votes. In the bigg boss season 10 full episode (BB10) full written updates of the show check them out from here – Crazzle News. In the house now we have seen that there is problem between Gaurav and Monalisa – Mona break down after listening to gaurav she added that May be I will be eliminated this weekend on 6th November 2016.
- Vj bani – 4 votes
- Gaurav – 5 votes
- Om swamiji – 4 votes
Bigg boss 10 contestants in the danger Zone can be eliminated :-
- Swami Omji
- NItibha
- Monalisa
There are lots of the actions seen in the Bigg boss house – Lopamundra's and Bani fight, OM swamiji addresses Bani daayin just because she was not indulge in the Diwali Laxmi pooja. Also there is problem between the Nitibha and Lopamundra because in the previous episode Nitibha got a call from the Viewer who asked her that their is double standards in her character.
Initially when Manveer had a words to nitibha she had fight with him but at the same time when Manveer had verbal fight then Nitibha supported him. Well there are lots of the mess going on in the Bigg boss house all the peeps of Bigg boss house are tired of hearing Swam om's words and idiotary acts.
Well we have seen that Rockon team came for their movie promotions well see that who is evicted from show, Who is 3rd elimination of Bigg Boss Season 10.
Monalisa, Nitibha or OM swami
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text:
Dark Cosmos Graduated Discs
Regular price $750.00
Set of 5 hand sculpted round graduated stoneware discs. Hand painted with a dark cosmos pattern
Measures approximately 9" x 35"
All work is made to order and ships in 4-6 weeks. Please email email@example.com to enquire about immediate availability
Hand made in NYC
All items ship in 4-8 weeks, please contact us to inquire about immediate delivery
Thank you!
You might also like
Regular price $115.00
Regular price $280.00
From $1,370.00


text:
rwe ag (RWE:Xetra)
BOARD MEMBERS AFFILIATED WITH Stefan Judisch *
Member of Supervisory Board
The information and data displayed in this profile are created and managed by S&P Global Market Intelligence, a division of S&P Global. Bloomberg.com does not create or control the content. For inquiries, please contact S&P Global Market Intelligence directly by clicking here.
MOST CONNECTED PEOPLE TO Stefan Judisch
|Thomas Ludwig
|18 Relationships
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Sponsored Financial Commentaries
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text:
East Asia project: Pakistan
By: Najila Saenz
Hour 8
-The capital of Pakistan is Islamabad
-population is 196,117,4380 Pakistani
- Governemnt is Federal republic
-Mamnoon HussainPakistan, President
-Economy is the mixed economy
-Currency compared to the U.S. dollar is 102.75 rupees
-GDP per Capita 3,100 U.S. dollars
-Rank in the world GDP 177 US dollars
-Literacy rate 96% to 36%
-Life expectancy male:65years old
Female: 90 years old
-official language: English and Urdo
Tourist attractions
Lake Saiful MulkLake on the north of a mountain, a dis extremely beautiful. You can enjoy the scenery and learn about the glaciers that created the lake.
Concordia, KarakoramOasis for those who adore mountain climbing, and breath taking views. And you are able to view K2 the second most largest mountain in the world.
Karimabad is a little village where you can spend to your hearts desire of handicrafts, carpet, fruit, gemstones, and antiques.
Lake Saiful MulkLake
Concordia, Karakoram
Three historical events in Pakistan
1948 - Muhammed Ali Jinnah, leader of Pakistan, died. And creating the First war with India over the territory of Kashmir.
2006 September - Government signs peace accord to end fighting with Al-Qaeda militants in Waziristan areas close to the Afghan border.
2014 October - Malala Yousafzai from Pakistan, was shot in the head by the Taliban. But survived to help battle for girls' education. As she becomes the youngest person ever to win the Nobel Peace Prize.
Current events
The law seems to have no help to the dead men. Not a single person has been arrested or prosecuted. Even the police investigators admit they are not even looking for anyone. The uimaginable murders in Pakistan's greatest mystery in decades. A shady gang of serial killers, but the country's powerful military and its intelligent men aren't coming through with their ideas. Anti-Pakistani have begun to control the province. Children in school become more rebellious over singing the national anthem and holding up its flags, women have also joined the fight.
Economic success
I feel that my country s developing its success. T has improved since its begin in, but it is also still being held innovated today. With new leaders, and new tradition Pakistans economic has potential for success.
Company located in Pakistan
Company: shrimp
The shrimp company exports with other countries an increased by 35% this yearm declining with amount of shrimp in the area.
What Pakistan can do to improve
I think that my country could improve their economy, buy opening up more to trade around the whole world. And by making their literacy rate, priority fir their generations. Another thing they could do to improve could be to create more jobs to earn more money and food.


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$7,500.00 11 months ago
Snap On tool chests with tools - $7500 (Louisville)
Snap On roll away tool boxes. Top, Center, Bottom, Side and Shelve.Complete set with all tools included. 1/4, 3/8, 1/2, 1 inch socket sets, swivel sockets, sallow and deep well, metric and standard. Ratchets, extensions, break away bars. 1/4 up 1 1/4 wrenches metric and standard, gear wrenches, aluminum pipe wrenches, crow feet. screwdrivers, pliers, Hammers, pry bars, chisels, punches, air tools,
11 months ago
Potsdam, NY
$2,000.00 1 year ago
Snap on tool chests - $2000
Roll around chest with box on top
1 year ago
Tuscaloosa, AL
$449.00 1 year ago
Snap On 13 Drawer Stackable Tool Chests - $449 (2099 Perry Lane)
This is a used, but in solid condition Snap On two piece tool chest. Bottom is a 7 Drawer on casters. Top is a 6 level kind of thing with the narrow drawers and a nice pull over cover to cover them all. Solid red paint, a little bit of rust and some good honest wear from previous owners. It will look kickin chicken vintage in your garage.
1 year ago
Brunswick, GA
Contact Us 1 year ago
SNAP ON & MATCO PROFESSIONAL TOOL CHESTS, CLASSIC 96 & "SCREAMIN EAGLE (Carlock, IL)
For professional mechanics, wrench turners, etc., or anyone wanting to own the best in tool boxes, I am offering several of my Best Tool Boxes in my collection. They are Triple (3) Bay Tool Chests, a Snap On Classic 96, Yellow in color, and a MATCO Harley Davidson "Screamin' Eagle" Tool Chest. I have been collecting quality SNAP ON and MATCO tool boxes for many years now. Both tool chests are in S
1 year ago
LaSalle, IL
Contact Us


text:
Have you joined up the dots on your industrial network yet?
With the IIoT and Industry 4.0 becoming ever more important, we can also enable you to connect your factory not only to itself, but also to other sites and offices across your organisation. We have products that can help you...
World record: Infineon chip solves Rubik's Cube in 637 milliseconds
The Rubik's Cube was solved in just 637 thousandths of a second. At the "electronica" trade fair, the machine "Sub1 Reloaded" pulled off the feat with the help of microchips from Infineon.
Keep your PROFIBUS running and benefit from this special PB-T5 offer
For a limited time only, order the PB-T5 hand-held tester plus the station location and oscilloscope options and receive a 10.1" Windows tablet pre-loaded with PB-DIAG-Suite FREE for less than the standard selling price!
An introduction to TESSY and unit testing
This 1-day seminar will introduce the basics of software testing to the while focussing on unit, module and integration testing.
Network Diagnostics Roadshow
A 1-day seminar exploring best practices for diagnosing and solving faults on industrial networks


text:
Located in Maple Grove with its close proximity to downtown Minneapolis and the University of Minnesota, this area is very attractive for both families and businesses. Serving as the intersecting point for many important thoroughfares including Interstates 94, 694, 494 and Highway 169, this location makes it easily accessible to get around. The Fountains at Arbor Lakes building is centrally located in the middle of a very vibrant office and retail environment known as Arbor Lakes. With over 150 businesses, these three distinct shopping areas combined have more retail than the Mall of America, including unique, independent stores, specialty chains and national brands. Also included is a wide variety of restaurants, and a top notch selection of personal and professional services including banking, financial, medical, dental, beauty and spa centers, and four hotels (one with a water park) to relax in at the end of the day. Restaurants nearby include Maple Grove Mango Grill, Biaggi's Ristorante Italiano and Benihana.
Everything you need to make meetings run smoothly.
Reception team
There to greet you and your guests on arrival
Free WiFi
Secure, business-grade WiFi
Presentation tools
Flipchart, whiteboard, markers and projector if needed
Admin services
Access to support for document printing and copying
Make arrangements for tea, coffee and catering if needed
To find out more about Arbor Lakes speak to our team on 1-855-400-3575
There are three simple steps.
Register on our site or via our app to create your free Pay-as-you-go Regus account
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Input your credit card details, book your space with just a few clicks, and show up!
Whatever your business, whatever your budget we'll help find the right workspace.
Whatever your business, whatever your budget we'll help find the right workspace.


text:
I haven't been on OkCupid in nearly two years and have since met an amazing, equally kinky, and beautiful young woman. I am fortunate to have met an amazing woman that appreciates, loves and respects me as much as I do her. We are now married and she serves me willingly as my slave and submissive. We are both very happy together. As I mentioned, we are both very kinky and are currently looking to meet another woman, preferably bi-sexual that is interested in being dominated and having all sorts of kinky fun with us. If you are looking for a serious, monogamous committed relationship then please seek out some other man that will love you and only you. I am always happy to meet new people, so long as they respect the relationship I have with my wife/slave. I am also eager to meet any women interested in Erotic Hypnosis, regardless of whether they are interested in 'playing' with my wife and I. That said, thanks for checking out my profile.
For the most part I am a man of unquenchable imagination. It is truly a beast that cannot be broken, nor bent. Writing is one of the ways to curb the demons of the soul. Another way is through strong drink, however that road can be rather crooked when in distasteful company. When I write the words flow from me as if they have no time for conscious thought. Boundless pyres of knowledge and emotion spew forth. I find myself blissfully overrun by my own passions. Eventually the flames die down and I am re-born. A child of Zeus with a mortal mans heart..
Perfection is an illusion that some expect from us. Worse then that we often expect it from ourselves as well. I thrive on things that make me 'feel'. If it were not for the painful times we might never recognize the blissful moments in life. My pain is what makes me whole. Like Floater says: "One without sun, one without shadow, one without anger is one who's not whole."
It's difficult to write about myself, as I only see me from the inside looking out. Therefore my interpretation of myself will always be skewed compared to others perception of me. I'm sure it's easy to see my flaws, but those that look deeper will see the parts of me that truly shine. I have a deep need to be loyal and honest, especially to those that I hold dear. My heart seeks out truth and absolutely despises anything that attempts to stifle free thought. In some ways I consider myself to be a prophet that has lost his path. My purpose in life is to help those that need guidance and perhaps in turn find my own way.
**Update: August, 2014**
~ For a bit over a year now I've been doing stand up comedy. I'd always wanted to be a comedian and I am finally living that dream. As of now I've performed around Chico, Redding, Sacramento, and Santa Cruz. I couldn't be happier finally pursuing a lifelong dream.. Also, I greatly enjoy Bacon. ..that is all.
Giving advice when it's asked for.
Philosophical, and/or introspective thinking.
My friends.
Nature and all its glory.
Self Expression.
My lovely wife's support, devotion and love.
If you have any interest in erotic hypnosis, or being hypnotized in general you should drop me a line. I have been into hypnosis since I was a kid, and enjoy helping women explore their sexual fantasies.
My wife is submissive to me and chooses to be my slave. She and I greatly enjoy the Dominant/submissive lifestyle. We are currently looking for another submissive to play with, so if you are interested in getting to know us and possibly 'playing' together message me.


text: Sometimes online casino players take it for granted that you can play casino games online from any location, at any time, on a PC via downloaded or online casino software or with a mobile device at the mobile casino. This wasn't always the case. Prior to the 1990s gambling was limited to large Vegas-type land-based casino venues or, for people who wanted to stay closer to home, to a neighborhood pick-up game or through a corner bookie. Since 1994 casino games have been accessible online, allowing real money gamblers to sign into their online casino accounts and play at their leisure. Every year the options for online gambling increase with more enticing and exciting game options. Players have their choice of playing card games, table games, arcade games, variety games, lotteries and slots. Some players stick to one type of game while others enjoy moving around and exploring different features that the casino offers. There are options to play for free in the casino's Free Mode but of course, when you play for free, you don't realize payouts on your wins. If you expect to win prizes, you might be asking yourself "what's the best strategy to achieve these rewards? Casino advisors offer recommendations which range from the types of games to play to the kinds of deposits to make. There are varying opinions but most casino advisors agree that, in order to realize the best results from a gaming episode, you must ensure that you enter the casino in a focused and calm state of mind. To accomplish that, consider what needs to be done before you enter the casino. Perhaps you relax best by practicing yoga or maybe you prefer to do breathing exercises. You might achieve a calm state of mind by simply sipping a cup of herbal tea. Many players find that they achieve the most satisfying casino event when they work on coloring for grown ups pages before they begin to play casino games. Coloring for adults is a soothing pre-gaming pursuit that imbues a tranquil environment. That serenity carries over to the casino gambling experience so the player experiences a sense of tranquility that allows him to focus clearly and make the best decisions for every individual game situation. In some cases, players who want to expand their neural cells to prepare for their gaming adventure note that when they work on solving a maze, they enjoy pre-casino relaxation along with the sense of accomplishment that comes from solving the maze. The process of solving mazes has been shown to stimulate the brain's cortex which then expands neural pathways, resulting in the regeneration of new brain cells and subsequent positive cognitive functioning. Try to solve this maze and then check the solution here!


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NEW YORK ( TheStreet -- SodaStream ( SODA) skyrocketed 74% after going public last week. That jump effectively placed a $700 million valuation on a company that only had income of $5.6 million for the first six months ending June 30, 2010. The stock has since started to pull back, and perhaps when investors get to the bottom of the bottle they'll question whether Soda Stream, who's EBITDA equaled only 10% of its net income for those six months is worth the high price.
IPHI) revenues have been climbing every year, with roughly 33% coming from Samsung and 12% from Micron ( MU). It is a fabless provider of high-speed analog semiconductor products and many of its customers are based in Asia. IPO Desktop analyst Francis Gaskins acknowledges that the company faces competition from big names like Broadcom ( BRCM) and NetLogic ( NETL) and that technology is moving away from analog to digital. But he notes that the stock's price-to-sales ratio of 3.8X is less than MaxLinear ( MXL) (4.5) and only slightly higher than Broadcom (3.0). "It looks like a safe bet at the IPO price of $9.50," Gaskins says. RDA Microelectronics: RDA Microelectronics ( RDA)is a fabless designer of mixed signal semiconductor chips. Many of their products are used in mobile handsets, MP3 players and a host of other consumer electronic devices. The company delivered $149 million in sales over the last 12 months, and the price-to-earnings ratio on the stock is around 13X, a little higher than Texas Instruments ( TXN) (10) and STMicroelectronics ( STM) (10), but lower than Broadcom (17). This is a capital intensive business and the company hopes to raise $71 million in the offering to finance growth and develop products. "They have tremendous sales growth," says Gaskins. "That one should do quite well." Noah Holdings: Noah Holdings ( NOAH) is a wealth management company in China with 300 relationship managers in 28 offices, and sales have increased 260% and income jumped 500% last year. Gaskins notes that the industry is in an embryonic stage because 80% of China's high net worth individuals make their own decisions. However, Noah's providers are independent and not affiliated with banks, which they feel will win the clients trust. The average transaction value per client went from half a million in 2009 to one million in 2010. Gaskins likes the numbers and thinks it will be a good IPO. The proceeds will be used to set up new offices and update the IT infrastructure.


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Currency trading and the euro. The price volatility of the euro has shown growth, but as a result renewed decline against the US dollar. It should be noted that the reason for the growth of the euro was the weakening of the US currency after on Friday was released statistics on retail sales in the US, which showed zero growth vs. an expected increase by 0.4% and the previous growth by 0.8%. Today, the dynamics of trade can affect the data on the index of business activity in the manufacturing sector of New York (12:30 GMT). Tomorrow will be published important statistics on consumer prices in the US that can greatly affect investors' expectations regarding the timing of the Fed raising interest rates. We forecast a decline of the euro in the near future and medium term.
Currency trading and the British pound. The price of the British pound continued its decline amid negative expectations of pressure on the country's exit from the EU, which will hit the UK's economy. In addition, on Friday was released the data on production in the construction sector of the country, which fell by 0.9% in June against the expected growth of 0.9%. Investors are waiting for the publication of reports on inflation in the UK tomorrow and the labor market in the country on Wednesday. Our medium-term outlook remains negative and the potential of a possible correction is low.
Currency trading and the Japanese yen. The price of the Japanese yen remained virtually unchanged despite the unexpectedly weak performance of the Japanese economy in the second quarter. Thus, the country's GDP showed zero growth, which is 0.2% worse than expected. The reason for this result was the decrease in personal spending and exports. On the dynamics of trading today will also affect news on industrial production for June. Earlier, the Japanese government decided on stimulation measures for 28.1 trillion yen, which should speed up inflation, but at the moment, the yen continues to rise against the background of a strong interest in defensive assets. Our medium-term outlook remains negative for the yen, and the potential for further strengthening has decreased.
Currency trading and the Australian dollar. The price of the Australian dollar fell against the US dollar on the background of weak statistics from China, which is the main trading partner for Australia. Thus, the volume of industrial production grew by 6.0% in July, which is 0.2% less than the forecast. Rising oil prices may not lead to a change of the negative dynamics. Tomorrow will be released minutes of the previous meeting of the Reserve Bank of Australia on monetary policy, which may enhance expectations of further lowering the key interest rate at the time of the next meeting. Investors also expect important statistics on employment in the country, which will be published on Thursday. Our medium term forecast is negative.
Currency trading and the New Zealand dollar. Price of the New Zealand dollar fell following the Australian currency. Investors fixed position after a strong growth in the previous weeks. Strong influence on the course of trading this week will be have the release of the report on unemployment in New Zealand on Tuesday night. The recent decline in the interest rate of the Reserve Bank of New Zealand coupled with expectations of further easing of monetary policy will continue to put pressure on the price of the local currency. Our medium-term outlook remains negative.


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The idea of a "villa" on the beach, out of the way of Nassau, and based on some of the reviews on here, made us book 5 nights in August 2011. The reservation included the room only, breakfast excluded, but we were told that the "restaurant" would be available for breakfast, lunch and dinner. After the experience on the first morning, where two toast breads, some synthetic jam and bottled juice and some tea (tea bags) set us back $25, we never returned.
Exploring the "private" beach, we found it full of washed up beer bottles, debris, dog poo and generally not a nice play to be, next to an abandoned house on the beach.
Keen to explore Bahamas, we very quickly realised that car rental is a must. Nearest super market is about 2 kilometers away, and since we didn't want to revisit the restaurant we had to stock up on essential breakfast supplies. Obviously we should have booked a car in the airport, but since the property offered car rental too, we took this option. We were greeted by a wreck of a Nissan Micra, where one mirror was knocked off, that badly pulled to the left and made some very worrying sounds when braking. The price was about twice what a rental from the airport would have been, as we belatedly discovered.
The "villa" itself was the ground floor of a row of houses, with the family of the owners staying in the top floor. Everything was very basic, with a small kitchen, a basic bathroom and a very small living room (the ceiling of which had a huge water damage). The bed room faced the back, so was quiet, and the air conditioning made the dampness of the room acceptable...
The overall feeling we got was one of neglect (the beach would have been a very nice feature if someone had bothered to take care of it), and the rooms were very basic. The final nail in the coffin is that the property is family-run and pretends to be very friendly and "folksy" as long as you don't question any of the deficiencies. As soon as you ask for anything out of the ordinary, such as a late check-out, or queries the state of the rental car, you are immediately met with a "not possible", or "that will cost you an extra half day rental".
All in all, a disappointing stay.
- Reservation Options:
- TripAdvisor is proud to partner with Expedia, Orbitz, Hotels.com, Booking.com, Cancelon, TripOnline SA, Travelocity and Hotwire so you can book your Coral Harbour Beach House and Villas reservations with confidence. We help millions of travelers each month to find the perfect hotel for both vacation and business trips, always with the best discounts and special offers.
- Also Known As:
- Coral Harbour Beach House And Villas Hotel Nassau
- Coral Harbour Beach Hotel
- Coral Harbour Beach House And Villas Bahamas/Nassau


text: I have stayed at the Stanley three times, in recent years. In reading the reviews and expectations, I wanted to clear some things up. This hotel is not about the food *although I did love the fajitas served in the bar), amenities (nice fire is usually going in the lobby), accommodations (the rooms can be small but quirky and fun)... More


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The L.A. Times is reporting that the zebra mussel (Dreissena polymorpha) has just been discovered in the state of California. Over the past several months, California has been dealing with the repercussions of the discovery of multiple populations of quagga mussels (Dreissena bugensis) but until now, had not seen the quagga's better known relative. There is some concern from state officials about the consequences of the introduction since the zebra mussels are located in San Justo Reservoir, which supplies water to farmers and homeowners in San Benito County. As of right now, the extent of the invasion is not known, but it is likely that this will result in some changes over the coming months regarding the way this reservoir and fishing site is used.
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It's been great 2 days relaxing in here. Very friendly staff. Thank you
Mr & Mrs H Scotland
What Our guests Think
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This stock has rebounded from its bottom, making it much more attractive. But have investors already missed the move?
Dow Chemical said Tuesday it hopes to sell about $1.63 billion in common stock to pay down debt from its recent acquisition of Rohm & Haas.
Cramer won't recommend any companies that can't afford to raise their dividends. Here's one that can.
Dow Chemical and Rohm & Haas are in "longshot talks" to settle their dispute over Dow's stalled takeover of Rohm, CNBC learned, citing sources familiar with the situation.
Dow Chemical and Rohm & Haas, which will face off in a Delaware court next Monday to determine Dow's $78 cash deal to acquire Rohm & Haas, are engaged in talks to find a resolution to their dispute, CNBC has learned.
Plus, Cramer extends an invitation to Pepsi's Indra Nooyi, talks technicals and makes a call on Dow Chemical.
It's amazing how much damage one man can do in such a short period of time.
Who among Bernie's $50 billion worth of investors should get their money back? And what if some were in on the scam?
Mortgage rates are falling, a housing bottom looks near, oil's at $34, and GM lives to see another day.
With an unsafe dividend, exposure to slowing industries and that big run in a very short time, Cramer thinks this stock is a sell.
This is the sector to own, but not just any stock will do. Find out which name is Mad Money's favorite.
A big dividend makes this stock a buy, buy, buy.
U.S. companies ranging from chemicals like Du Pont, to pharmas like Pfizer and Schering Plough, and financials like Fifth Third and BlackRock, reported earnings Tuesday.
European earnings were mixed Thursday, with telecoms reporting results in line or above forecasts, while energy companies and financials posted profit declines or figures below market expectations.
Dow Chemical posted second-quarter earnings that fell short of market expectations as its price increases did not completely offset a sharp spike in energy and raw material costs.
Chemical maker DuPont Tuesday posted higher-than-expected quarterly earnings as strong demand for its corn and soybean seeds offset weakness in the domestic housing and automotive markets.
A flurry of consolidation in the industry has Cramer predicting what could be next to go.
Ashland, which makes chemicals and Valvoline motor oil, said on Friday that it would acquire Hercules in a $2.6 billion cash-and-stock deal that would significantly boost its product offerings.
Warren Buffett's Berkshire Hathaway is helping to finance Dow's just-announced deal to buy specialty chemical maker Rohm and Haas for over $15 billion in cash. Berkshire is contributing an equity investment in the form of $3 billion worth of convertible preferred securities. The Kuwait Investment Authority is also making a $1 billion investment.


text: I heard about the Playstation Plus membership before but I never really looked into it. Boy was I wrong not to. I purchased a 3 month subscription for 17.99 just to give it a shot and it was definitely worth it! There's a pretty solid collection of games available for free download! I already downloaded Kingdoms of Amalur and plan on getting XCOM: Enemy unknown next. Just by downloading Kingdoms of Amalur I've already gotten back what i payed for with the membership which really speaks to the value of the subscription. There's not really much else to say on the matter; it's just great value. The primary reason i got PS Plus was for the instant games collection but the 1GB cloud storage and instant updates are pretty handy as well. The only regret that i have about it is that i got it around when GTA 5 and Pokemon Y were released, too many games to play! First world problems eh?


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Carol Reichenthal, Ph.D.
Carol Reichenthal, Ph.D.
|Professions: Psychologist, Psychotherapist, Other
|License Status: I'm a licensed professional.
|Primary Credential: Psychologist - 1799
|Office 1
Suite 225
Brookline, Massachusetts 02446 Click for Map Get Directions
|Office 2
Andover, Massachusetts 01810 Click for Map Get Directions
Billing and Insurance
I don't currently accept insurance, but I can provide documentation if clients wish to submit to an insurance company for "out of network" benefit coverage
Fees: My fees are within the range for experienced clinicians in this area. I do accept HMO Blue insurance and I am happy to work with you to navigate the often confusing health insurance landscape. I provide the courtesy to the people I work with of billing most insurance companies directly (as an out of network provider) or if you prefer I can provide you with all the information you need for directly submitting for reimbursement yourself. Please check with your insurance company to see if you have out of network benefits and to know if you have a deductible and how much that is. If you have that information you can find a therapist who will be a good fit for you, which is so important!
See other therapists in Brookline, MA.
See other therapists in Andover, MA.
Life can simply work better at times with some help.
Psychotherapy is an effective tool, both to resolve deep seated difficulties rooted in the past and to make headway with the more immediate issues in our present day lives. It can help relieve anxiety, depression and stress and can help you with relationships with family, at work and in a more general way.
My approach is interactive, using a psychoanalytic context to understand current difficulties. While clients want to better deal with long-standing issues rooted in the past, they also want present - oriented help resolving these troubles.
Email or Call Carol Reichenthal, Ph.D. at 1-800-651-8085 ext. 00241
More Info About My Practice
In my practice, I tend to work with a wide range of people who are high functioning but suffering emotional pain. I see students, graduate students, financial professionals, business people, attorneys, medical professionals, and others from all walks of life. Suffering isn't the sole province of any one group.
Of course therapy also entails payment for professional services. I arrange fees that are mutually agreeable.
And I am happy to help you navigate through the often confusing insurance system if you request that. Many insurance plans (PPO or POS for instance) cover out of network doctors. Please check with your Insurance Company to see if out of network coverage is available for psychotherapy with me.
My View on the Purpose of Psychotherapy
Although psychotherapy has multiple purposes, most people find the central purpose to be relief from emotional suffering. We start there. But there can also be motivations that include understanding difficult patterns within relationships, families and at work-- to know yourself more deeply and better. That can help tremendously in moving forward in life.
What I Love about Being a Psychotherapist
I feel that being a psychotherapist is a wonderful profession! Each individual, and his or her life narrative, is unique, interesting and complex. Doing psychotherapy is a way to help people, to be constantly deepening one's skills, and to learn about each unique patient with whom you're working.
Services I Provide
- Clinical Supervision
- Coaching
- Consultation
- Individual Therapy & Counseling
- Marriage, Couples, or Relationship Counseling
Ages I Work With
- Adults
- Elders
- English
Client Concerns I Treat
- Academic Concerns
- Adjusting to Change / Life Transitions
- Anxiety
- Caregiver Issues / Stress
- Creative Blocks
- Depression
- Divorce / Divorce Adjustment
- Family of Origin Issues
- Family Problems
- Grief, Loss, and Bereavement
- Midlife Crisis / Midlife Transition
- Pre-Marital Counseling
- Relationships and Marriage
- Stress
- Women's Issues
- Workplace Issues
Types of Therapy
- Depth Therapy
- Depth-Oriented Brief Therapy
- Integration of different therapy models
- Interpersonal Psychotherapy
- Psychodynamic
- Relational Psychotherapy
- Relationship Enhancement Therapy
By using this site, you signify your assent and agreement to the Terms of Service.


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Iran has suspended plans to stone to death a 43-year-old woman convicted of adultery, Iran Press TV reports.
The Iranian news agency quotes Iranian Foreign Ministry spokesman Ramin Mehmanparast as saying the adultery conviction against Sakineh Mohammadi Ashtiani is being "reviewed."
The European Parliament today condemned the stoning sentence, saying that the punishment "can never be justified or accepted," the Associated Press reports.
Mehmanparast told Iran Press TV that "certain Western countries" are using the case to exploit the case to put pressure on Iran over its nuclear work.
"He also said Ashtiani's sentencing for alleged complicity in the murder of her husband is "in process."
Ashtiani was convicted in 2006 of having an "illicit relationship" with two men after the murder of her husband the year before and was sentenced to 99 lashes, the AP reports from Tehran.
Later, she was also convicted of adultery and sentenced to be stoned, even though she said her confession was made under duress, the AP says.
After putting the stoning sentence on hold, Iran suddenly announced she had also been convicted of playing a role in her husband's 2005 murder, although lawyer Javid Houtan Kian argues that no charges against her in the killing have ever been part of her case file.
(Posted by Doug Stanglin)
Doug is an unrepentant news junkie who loves breaking news and has been known to watch C-SPAN even on vacation. He has covered a wide range of domestic and international news stories, from prison riots in Oklahoma to the Moscow coup against Mikhail Gorbachev. Doug previously served as foreign editor at USA TODAY. More about Doug
Michael Winter has been a daily contributor to On Deadline since its debut in January 2006. His journalism career began in the prehistoric Ink Era, and he was an early adapter at the dawn of the Digital Age. His varied experience includes editing at the San Jose Mercury News and The Philadelphia Inquirer.
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