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subset: commoncrawl


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|ImmunoTX Summit
Immunogenicity & Immunotoxicity
Immunotherapeutics & Immunomonitoring
Cytokines & Inflammation
Dear Colleague,
We invite you to GTCbio's ImmunoTX Summit, which takes place on February 1-2, 2018 in San Diego, CA. The summit will bring together our usual balance of industry and academia, so that delegates have the unique opportunity to network with colleagues from different sectors and gain a fresh perspective on the various topics below.
Joint Plenary Sessions:
- Opening Keynote Session – Historical Perspective & Current State of the Industry
- Round Table Discussions
- Ready, Set, Grow! – New Company Pitch Competition
- Award Ceremony & Closing Keynote Session – Predictions for future
- Metabolic Regulation of Immunity & Inflammation
- Influence of Microbiome on Immune Responses
- Targeting Cytokines for Therapeutic Interventions
- Innate Immunity in Respiratory Diseases
10th Immunotherapeutics & Immunomonitoring
- Conditioning the Tumor Microenvironment for Immunotherapy
- Immunomonitoring & Novel High Throughput Technologies
- Combination Immunotherapy
6th Immunogenicity & Immunotoxicity
- Strategic Modulation of Immunogenecity
- Molecular Mechanisms of Immunogenecity
- Immunogenecity Assessment of Novel Drug Candidates
- Immunogenecity Assessment of Biosimilars
We hope to see you there!
Best regards,
The 2018 Organizing Committee
Amber Kempf at 626-256-6405 or amber.kempf [at] gtcbio.com
Exhibit Sponsor
ACEA Biosciences, Inc. is a pioneer in the development and commercialization of highperformance microelectronic systems for cell-based assays. ACEA's xCELLigence® systems are widely used in academic labs, government institutions, biotech and pharma companies around the world to study cell adhesion, cell migration/invasion, GPCR/RTK signaling, cell proliferation and compound/cell/viral-mediated cytotoxicity.
Program Partners
Cancer Genetics Inc. (CGI; Nasdaq: CGIX) is a leader in enabling precision medicine in oncology from bench to bedside through the use of oncology biomarkers and molecular testing. CGI is developing a global footprint with locations in the US, India and China. The Company offers a comprehensive range of laboratory services that provide critical genomic and biomarker information. Its state-of-the-art reference labs are CLIA-certified and CAP-accredited in the US and have licensure from several states including New York State. CGI has established strong clinical research collaborations with major cancer centers such as Memorial Sloan Kettering, The Cleveland Clinic, Mayo Clinic, Keck School of Medicine at USC and the National Cancer Institute.
Platinum Sponsors
SQI Diagnostics is a life sciences company that provides clinical grade multiplexed assays and its automated instrumentation to the pharmaceutical research market. SQI develops custom ADA, epitope mapping, multiplexed PK assays, biomarker, and many other assays all in one well making it the leader in the multiplexing of therapeutic proteins, isotypes and subclasses in a single well.
Our goal is simply to help researchers gain a better understanding of proteins and their role in disease. We develop and commercialize proprietary systems and consumables for protein analysis that ultimately help reveal new insights into the true nature of proteins. Our goal is to make protein analysis simpler, more quantitative and affordable. Our comprehensive portfolio of tools includes Simple Western systems that quantify protein expression and Biologics systems that probe the structure and purity of protein-based therapeutics.
Since 1988, PeproTech has grown into a global enterprise manufacturing an extensive line of Recombinant Human, Murine and Rat Cytokines, Animal-Free Recombinant Cytokines, Monoclonal Antibodies, Affinity Purified Polyclonal Antibodies, Affinity Purified Biotinylated Polyclonal Antibodies, ELISA Development Kits, Cell Culture Media Products and GMP Cytokines.
Euro Diagnostica offers versatile assay solutions and cutting-edge tools to pharma, biotech and CRO customers. Facilitating the development of safe and efficient drugs as well as an optimal treatment of patients, Euro Diagnostica is an optimal partner during the whole drug development continuum.
AllCells is a biotechnology company that provides hematological/immunological tissue products and expertise in bioservices worldwide. Our products include clinical grade tissue and primary cells, diseased cells, and whole blood for scientific research use. AllCells is fully certified in accordance with local, state and federal requirements and was established in 1998.
Myriad RBM, Inc. is the world's leading multiplexed immunoassay testing laboratory, providing comprehensive protein biomarker services based on its Multi-Analyte Profiling (MAP) technology platform. This platform provides pre-clinical and clinical researchers with reproducible and quantitative data for a few or hundreds of proteins in a cost-effective manner.
Fidelta is a preclinical CRO offering services in ADME, Medicinal Chemistry, in vivo, in vitro and translational projects. We focus on the therapeutic areas involved in Respiratory, Inflammation, Fibrosis, Invectives and Oncology. Besides our standard models and assays, we also offer customized development and validation.
SomaLogic measure 1,310 proteins simultaneously from 65 µL of sample with high sensitivity, specificity and reproducibility. We enable biomarker discovery, better understanding of pathways, target identification, target validation and understanding of off-target effects. We can scale our technology from a large plex (1,310 proteins), to individual analytes, and to panels.
ABL, Inc. is a CMO/CRO with facilities in the US and Europe that provides diverse services for biologics development and manufacturing (protein and viral). ABL offers; PD, GMP manufacturing, preclinical and clinical development, comprehensive immunological services, clinical immunogenicity testing, GCLP trial sample processing and testing and many other services. www.ablinc.com
Corporate Partners
Using novel epigenetic technology, Epiontis provides precise and reproducible immunomonitoring services for clinical trials. The epigenetic PCR tests are based on in-house developed and IP protected markers specific for immune cell types (Treg, Th17, overall Tcells, etc.). Frozen whole blood or tissue can be used, permitting easy storage and logistics.


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Let us know when your receive great advice so we can thank our lawyers and point others with similar questions in the right direction.Got it!
Is provisional waiver some kind of immigration benefit .
Relief usually means a benefit in lieu of removal from the United States. A provisional waiver is not an application for relief from removal.
The above is intended only as general information, and does not constitute legal advice. You must speak with an attorney to discuss your individual case.Ask a similar question
A waiver is a type of immigration benefit that allows someone to enter the United States even though they have taken part in some behavior that would otherwise cause them to be prohibited from entering. The provisional waiver is just a change in the way you apply for waivers. Before the provisional waiver, many people had to leave the U.S. and apply for a waiver in their native country. They would leave without having any idea of whether the waiver would be approved, and if it was not approved, they would be stuck outside the U.S. for some time. The provisional waiver allows a certain group of people who otherwise would have to leave the U.S. to apply for a waiver, to apply for a provisional waiver without leaving the U.S. A grant of a provisional waiver is not a final decision of their waiver application. But it means they can leave tohe U.S.. to apply for their immigrant visa with a pretty good assurance that their waiver will be ultimately granted and they will not get stuck. If you are interested in applying for one of these waivers, consult with a good immigration attorney first to make sure you are eligible and that it is the best strategy for you.
Christina Murdoch
Scott D. Pollock & Associates, P.C.
105 W. Madison St., Suite 2200
Chicago, IL 60602
(312) 444-1940
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Please visit our renovated website at www.lawfirm1.com, which allows client access to case status, enhanced information on services, and other convenient features.
When an immigration judge or attorney says "relief," he or she is typically referring to applications for permission to remain in the United States instead of being deported. In order to submit an application for relief, you have to meet the requirements for a specific form of relief authorized by law. There is no general application for relief.
A provisional waiver is not within the jurisdiction of the immigration court, meaning the immigration court does not have the power to make a decision on an application for a provisional waiver. Provisional waivers are within jurisdiction of USCIS.
I suppose that someone seeking in a broad sense could refer to a provisional waiver as relief from the harshest consequences of unlawful presence, but that is not typically how the term is used.
Heather L. Garvock Attorney Ellis Porter, PLC 2701 Troy Center Dr., 410 Troy, MI 48084 Phone: 248-519-9900 Fax: 248-519-9901 Email: email@example.com For more information about current issues and developments in immigration law, visit my blog: www.miimmigrationnews.com The information I provide on my blog and Avvo is for informational purposes only and does not constitute legal advice or create an attorney client relationship.Ask a similar question
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American Flyer S scale - Gondola train car w/4 containers in good condition !!!
- Sold for: Start Free Trial or Sign In to see what it's worth.
- Item Category: Toys, Dolls, Games & Puzzles
- Source: eBay
- Sold Date: Mar 22, 2012
- Channel: Auction House Sell similar item on eBay
Here's a American Flyer Gondola train car - Deleware & Hudson 916 in very good condition, S scale with 4 - the LCL Corporation containers in good condition. I got this from Antique mall. Email questions. Thanks !


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Some live in nursing homes, as you might expect of men who are pushing 100 years old, and few can walk without help. But today, on the 80th anniversary of the end of World War I, a dozen or so surviving British veterans gathered here at a museum devoted to the memory of war to receive one of France's highest distinctions and to hear, in the most ringing tones, that they have not been forgotten.
''On the 11th of November, 1918, at 11 A.M., the sound of bugles echoed from trench to trench, ending a war that had scarred that generation forever,'' said Daniel Bernard, France's Ambassador to Britain, as he affixed the Chevalier Cross of the Legion of Honor onto the chest of each veteran. ''British veterans of the Great War, France wants you to know that she remembers, and from the bottom of her heart says, 'Thank you.' ''
Two years ago France presented the medal to all French veterans of the First World War. But today, well aware that this is the last time any significant number of World War I veterans is likely to be alive on such a significant anniversary, the country searched out veterans from around the world. It found about 200 in Britain. Many were too infirm to attend the ceremony. Those who did had clearly made the greatest of efforts to be there.
''It was, of course, a world war, and hundreds of thousands of Allied soldiers made the supreme sacrifice on French soil,'' Mr. Bernard said. ''It is absolutely right to honor Allied veterans in the same way as their French comrades.''
As they sat stiffly in the grand atrium of the British War Museum, with planes from past wars suspended over their heads and dozens of proud relatives surrounding them, the men found their minds going back to that terrible time many years ago.Continue reading the main story
Albert Marshall, 101, remembered how he was shot in his right hand and, after returning to Britain for treatment, re-enlisted and went back to France to fight again. Percy Lorriman, a week shy of his 100th birthday, said that as much as he tried to forget the horrors of war, the memory of his lost friends and relatives flooded back.
And Ernest Argall, 99, who worked as one of the world's first wartime wireless operators, thrilled as he recalled the best message that ever came across his radio: the message that the Armistice ending the war had been signed.
''I was lucky in that I didn't have to fight in the trenches,'' Mr. Argall said. ''But you can't forget it. I lost dozens of school friends, no end of friends. Their lives were chucked away, and I came away with the overall impression that lives didn't matter. I was really sickened by it.''
Mr. Lorriman said he was delighted to accept the award, presented with a Gallic double-kiss on the cheeks by the Ambassador, on behalf of all his fellow soldiers. ''I appreciate that the French have decided to honor all the lads -- not just me,'' he said. ''What would have happened to them without us, I don't know.''
Many of the veterans said they had always been reluctant to talk about their experiences, which took place at a time when men were not supposed to complain, discuss their problems or weep for the past.
''You lost someone nearly every day, but you just met trouble as it came,'' said Mr. Marshall, who served in the cavalry and machine gun divisions and today sat proudly in his wheelchair in a tweed suit, his chest heavy with medals. ''The shells and the bombs and the machine guns and what you will. It was difficult to come back and start a new life.''
Mr. Marshall's 67-year-old son, John, said his father had a first-rate memory but had always been reticent about the war. ''He's seen such horrible things, that's the problem,'' said John Marshall. ''We've learned more about his experiences in the last few weeks, as today approached, then we'd ever learned before.''
The ceremony came during a weekend of remembrance, in which Britain commemorates those who survived its wars, and those who did not. In a nation that has seen two generations effectively wiped out by this century's two great conflicts, war has always been a part of life. But after 50 years of peace, the memories are fading rapidly.
''It's unimaginable for our generation,'' said Caroline Kenyon, sitting in the audience during the ceremony. ''This is particularly relevant for me, because my grandfather was in the trenches for four years during the war, and he never recovered. He had the most terrible shell-shock, the most terrible nightmares.''
Brenda Barratt, whose uncle, Clarence Luscombe, 99, fought in the war by lying about his age when he volunteered, looked on with affection as Mr. Luscombe stood tall and said ''Merci'' as he received his medal. ''I think they need remembering,'' Mrs. Barratt said of the veterans. ''In France, as the Ambassador said, it's a duty to remember. I think that's true of all of us.''Continue reading the main story


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In case you were caught dropping the ball, the "Now Or Never" remix is out. And boy oh boy did all the Microphone Controllers bring it! We took to the social media streets to see which verse or verses are your favorite, from the street anthem.... All Niggas went in
Tag: MostQuoted
Total 1 Post


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Picture: Prince Harry and Prince William, the Duke of Cambridge play in a polo match at Cirencester Polo Club Cirencester, England - 05.08.12
HRH Prince Harry may have put himself in the royal doghouse with his partying antics in Las Vegas, but he has done very little to deter people from visiting the Nevada resort, as the British enthusiasm to visit Sin City looks to be on the up.
Although the much-noted, notorious destination hardly needed a popularity boost, it seems that the man who is third in line for the British throne has given it this boost nonetheless. One British travel agent reported this week that the number of people inquiring into vacation packages to a Vegas resort destination has risen by 30 percent. Meanwhile, an online hotel booker has revealed that the number of searches for Las Vegas has more than doubled since Harry's debaucheries were published.
The iniquitous pictures of Prince Harry soon spread like wildfire on the net, and on Friday British tabloid paper The Sun published the pictures on its front page, breaking an unwritten Royal taboo. However few were on the newspaper's side when they published the images, with the paper generating more than 850 complaints from across the country, sent to UK media watchdog the Press Complaints Commission. Since then, papers across the Isle have published pieces both damning Harry, praising him and, perhaps most of all, offering useful guides to Brits who may be considering holidaying in Sin City.
As well as catching the eye of just about every newspaper in the country, Harry's antics have also caught the eye of adult video producers Vivid, who have asked the rambunctious royal to appear in an explicit video inspired by his Vegas activities. According to TMZ, Harry has been asked by the same company who made the infamous Octomom porno with Nadya Suleman in June this year, to make a XXX video and are offering the Prince a massive $10 million pay check if he agrees to do it.


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How to get from Victoria to Willesden Green station by tube, with a time estimate of how long it takes on the London Underground
Do you have to change trains? Yes
How many stops are there? 9
Tube route: Victoria → Green Park change train Green Park → Bond Street → Baker Street → St. Johns Wood → Swiss Cottage → Finchley Road → West Hampstead → Kilburn → Willesden Green
How long does it take? The journey time between these two London underground stations is approximately 30 minutes
Which fare zones? This tube journey is in zones 1 and 2. You can pay by PAYG oyster, with a visitor oyster card, zone 1-2 travelcard or contactless card. Look up the zone 1-2 fare for adults and zone 1-2 price for children
How far is it? The distance from Victoria station to Willesden Green station is roughly 5¼ miles. Here's an approximate taxi fare for 5¼ miles
Are the trains running? Your tube line may be affected by engineering works and closures. You should also check whether the tube train between Victoria and Willesden Green is affected by a London tube strike
Return journey: Willesden Green to Victoria station
Note: This journey has been created by a computer program and may not be the fastest possible route. Closures, cancellations and delays on the Victoria to Willesden Green tube route may affect your journey, and you should allow for some extra travel time on top
> Talk about Victoria to Willesden Green in the forum
London: A Visitor's Guide
Have you seen our guidebook? We explain how to ride the buses, boats, taxis and trains, with all the fares and ticket options
2017 edition – Read a free sample
Amazon.com, Amazon.co.uk and more
How much is the tube fare? The ticket price for Victoria to Willesden Green can be found under zones 1-2 (adult) and zones 1-2 (child)
Buy an Underground ticketHow to buy a tube ticket from Victoria to Willesden Green stationBuy an Oyster Card (learn more)
Buy a Visitor Oyster Card (learn more)
Buy a Travelcard (learn more)
Travelcard + London Pass (learn more)
Pay by contactlessBuy a National Rail ticketBuy from Trainline
Buy from Raileasy
Alternative train journey to Willesden Green:
St Jamess Park to Willesden Green, Sloane Square to Willesden Green or Pimlico to Willesden Green
Alternative train route from Victoria:
Victoria to Dollis Hill, Victoria to Kilburn or Victoria to Neasden
Get an Oyster for the cheapest fares The easiest way to travel in London
> Save moneyGet the cheapest fares on London transport
> Easy to usePay as you go credit on the buses, boats and underground trains


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It's Business Time: Fairmont Singapore Best Business Hotel in Singapore
There's a very interesting split in the travel industry between business and leisure travelers. And if you're one of the business types, you know well that you're on the road constantly and the things that matter to you, travel convenience, efficiency, and connectivity, are almost the opposite of what a leisure traveler might want. If the word 'secluded' ever appeared in a hotel description, you'd cross it off the list immediately. So I'm here to use some adjectives you might appreciate hearing in describing some of the world's best business hotels. Today? Singapore.
In real estate, it's all about three things: location, location, location. For the business traveler, it's much the same, and the good folks at Fairmont kept that in mind with the Fairmont Singapore. The hotel is located at the crossroads of Singapore's major business, cultural, and shopping districts. A staggering 70,000 square feet of meeting space means that you can host an event of just about any size in the hotel's wonderfully furnished top-of-the-line meeting rooms. The main ballroom itself can host up to 3200 people, and there's another auxiliary room that can hold up to 1,000. After you're done with business, relax and unwind, or treat your guests, at the Willow Stream Spa, one of the largest in the city, ensuring that you can find exactly what you're looking for. And with 769 rooms and suites, all of the executives can stay on-site; there's no having to worry about booking additional rooms and coordinating transportation to other hotels. The Fairmont Singapore is a business center in the center of business for Southeast Asia.
Banyan Tree Bintan
Bintan Island, Indonesia
Hike in a rainforest teeming with giant trees and lush life, hillside terrain, secluded beaches and the sweet song of birdlife. Immerse yourself in a natural sojourn on Bintan island. Banyan Tree Bintan delivers views of the... more >>
Four Seasons Singapore
Singapore, Singapore
Welcome to Four Seasons Hotel Singapore. Escape into a quiet garden enclave in the heart of the city – steps from Orchard Road shops and entertainment, and just minutes from the financial district. Enter a world that is... more >>
Shangri-La Hotel Singapore
Singapore, Singapore
Set in luxuriant tropical gardens near the renowned Orchard Road shopping and business district, Shangri-La Hotel, Singapore is a leading luxury hotel in Singapore which offers discerning travellers legendary Shangri-La... more >>
Fairmont Singapore
Singapore, Singapore
The Fairmont Singapore hotel is ideally situated at the crossroads of Singapore's business, cultural, entertainment and shopping districts. It offers 769 luxurious guest rooms and suites, a collection of 16 distinctive... more >>
Raffles Hotel Singapore
Singapore, Singapore
Note: The hotel will be undergoing renovations in phases starting in January 2017 to modernize the property. The hotel will be closing in late 2017 and re-opening in the 2nd quarter of 2018 for the final phase of upgrades.... more >>


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Nationals catcher Jesus Flores, whose laundry list of injuries has kept him out for a year and half already, has been shut down from his throwing program again in Viera, Fla, general manager Mike Rizzo said on MASN's broadcast of tonight's Nationals game. Flores had surgery to repair a torn labrum last fall, and has missed all of the season while trying to build strength in his shoulder.
While Rizzo said on the broadcast that the Nationals hope to get Flores going again after the All-Star break, my guess is they won't see him in the majors this year. If he's still got to go through a throwing program, he could be too late for a minor-league rehab stint. If that happened, he could come to the Nationals in September, but would do so having not played in a game in a year.
And if Flores doesn't play again this year, it's conceivable we've seen him in a Nationals uniform for the last time. He's arbitration-eligible after the season, though he'd be relatively cheap to bring back. But after putting in as much time as they have with the injury-prone catcher, the Nationals could decide to cut their losses.


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|Message view
|« Date » · « Thread »
|« Date » · « Thread »
|Thorsten Scherler <thors...@apache.org>
|Re: [PROPOSAL] A CMS for our Docs
|Mon, 06 Jun 2005 16:57:05 GMT
On Mon, 2005-06-06 at 16:12 +0100, Ross Gardler wrote: <snip/> > > I'm offering some of my time (post 0.7) to get this going. > > Can we count on the Lenya team to assist? > > Thorsten, do you still need to create the Forrest Lenya integration? Can > we count on some of your time for that part of it? Yes, I just wanted to state that I am not the only one in lenya-land that is willing to help. If it would have been like this I wouldn't want to be in the situation you described: > If we go for Lenya instead then we will have to rely on Thorsten to get > it up and running and do any modifications/integration we need > (hopefully my work on the Locationmap and Daisy integration will help here). I do not like that a community depends on one person (too much pressure). It is better when the two communities make it work together. Count on me in trying to help where I can! salu2 -- thorsten "Together we stand, divided we fall!" Hey you (Pink Floyd)
|View raw message


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Bismillahirrohmanirrohim.... This is the place where I am jotting down my daily lives, my experiences, travels, joys, and things I cherish in life.. along with my family's journeys. This has been a great and will be a beautifully ridden life. In short, did that, been there, will be...all those vistas.
Sunday, January 24, 2016
UT Korea Radio Awards
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text:
Website scrapping
I need someone who can create a data base of emails, address, and phone numbers of businesses listed on a certain website. There are several thousand emails, address and phone numbers that can be collected from this website. The website allows you search different areas and different type of businesses. I only need the business from California and I need the information for both deliveries and dispensaries.
P,lease let know how you will accomplish this task and how much it will cost. Please look at the website needed scrapped [url removed, login to view]
Thank you
Hi, I already have data for complete USA of weedmap around 7k records with name, address and other important details. if intereted please contact me. thanks
Hello, I am ready to extract data from weedmaps using python/scrapy/django. I've already extracted data from weedmaps. I've 10K+ Us ips. This website block ips so its bit hard to extract data but we've bulk proxies. 更多
Hi, I have checked the website there are lots of company info we can't find out the exact figure. So we can have make a deal per 100 entry. How many column would you need per each entry? I will scrap the data ma 更多
sir already i have read your description so i am 100% clear your task, just award me then right now i can start your task with my team,thanks
Hello, I have lot of experience in web scrapping and search. I have collected data from many sites. Please check my reviews. I am ready to start now. Thanks. Rich.
Sir i am ready to start your task its very easy for me i hope i can help you in this project and give you good job,so please contact me,thanks
Dear Sir I have ready 2K + data Please check screen short ( http://prntscr.com/da5w4r ) I can scrap again holl website . again if you want Please ask me sample. Waiting for your reply. Thank you
sir I am expert like this job,I have a expert team, so right now i can start your task.so please contact me,thanks
Hello, I have a lot of experience with web scraping and I would love to help you with this one. Please contact me for more information.
With 6.5 years work experience, I am confident that I am the best candidate for your vacancy. My Expertise Areas is in On/Off line Data Entry, Email and Contacts Collections, Product Research, PDF to Word and Excel, Wo 更多
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We have accomplished 90% of the project which is similar of your requirement. All we need 10% customization as per your requirement set and specifications. I want to discuss in personal chat in order to explore your ne 更多


text:
15 Years Boy Develops 100% Accurate Cancer Test Using Google
He felt the need for this invention when he lost his friend to Cancer. His close friend died because of Pancreatic cancer at a young age that broke his heart. He decided to ease the misery of many people by inventing this technique.
Some tests are also performed at the hospitals to diagnose Pancreatic cancer. Unfortunately, these tests are almost 60 years old while Pancreatic Cancer is still the fourth leading cause of mortality in the world. The major reason for this many deaths is the late Detection of Pancreatic Cancer
Jack Andraka gave a thought on how to develop a technique that can diagnose Pancreatic Cancer at an early stage. The teenager surprisingly succeeded in creating a test that diagnoses Pancreatic Cancer.
For this purpose, he utilized the information available on Wikipedia and Google. This intellectually minded teenage developed a test that takes only 5 minutes to answer at an expense of 3 cents.


text:
Crude oil 8-02-10
Last week i laid out the case for a rally possibly to the 82.60 area. I still feel as though oil is way overpriced up here , based on fundamentals. On the short term im expecting some resistance at 72.62-72.65...
yeah, as you know ,ive been targetting that area for a while today...going to bail on this long 81.35-45
the 1.618 is 81.42...2.618=81.62
stop now at breakeven...
out at 81.35!...i'll take it..
Originally posted by koolblue
out at 81.35!...i'll take it..
well, maybe, but i still think higher 81.42, and 81.62, and possibly even more...
nice trades guys. Scalped a few cents too.
Originally posted by einsteinThx1..but because of a loser earlier, im only up 6 cents!... but at least im up!
nice trades guys. Scalped a few cents too.
sold 81.61 per my earlier posts.. but this will be a real quickie!
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text: All sorts of arguments are thrown around to persuade parents that shots threaten their children with autism. I'd like to discuss 4 of the commonly repeated concerns, 3 flawed…and 1 that I think has merit. 1) Too many shots can overwhelm a child and cause autism. No! Babies get more vaccines today than 30 years ago, but if you think that means more things are injected into their young bodies…you'd be wrong! That's because immunizations today are much more purified than those of the past. For example, in 1980, the DPT shot (Diphtheria/Pertussis/Tetanus) was made from a soup of blendarized bacteria (over 1000 different illness particles – antigens – all mixed together). And, the polio vaccine had live virus that actually protected children by triggering a minute case of…polio! Today, our modern DPT vaccine is highly purified, containing only 3-5 bacterial antigens and the polio shot has absolutely no live virus. Actually, the current trend to give kids more shots is a win-win for them. They win because they're protected from many more illnesses and because they have fewer antigens put into their bodies. But, some still worry, "Can too many shots overwhelm a baby's immature immune system?" That idea is pretty close to a baby urban legend. The immune system is a superb multitasking, fighting machine. Every day, babies are bombarded by thousands of threats: irritating pollen; colonic microbes; bacterial invaders from the skin, eyes, nose, mouth; viral swarms; offending dietary proteins; damaged cells; even tiny, little cancers. The immune system's magnificent ability to protect against many, mild attacks at one time is exactly why most babies tolerate several shots at once with no reaction whatsoever. (In fact, a new theory suggests that allergies and asthma may be on the rise in part because we have made the world so clean it doesn't exercise a baby's immune system enough!) 2) Shots hurt the brains of extra-sensitive children. No! Each of us has special sensitivities. Some have peanut allergies…some get lots of strep throat….and a very, very few get serious reactions to vaccines. I wish we had a test to detect which infants are susceptible to severe measles or big vaccine reactions, but no such test exists. The good news, however, is that shot risks are tiny compared to the risks of full-blown illness. For example, influenza and chicken pox hammer the immune system 100-1000 times harder than the impact of the flu or pox vaccines. While most kids breeze through the chicken pox shot, even a mild case of real pox can weaken a child's immunity for weeks to months and lead to ear infections, pneumonia and, rarely, toxic shock syndrome. (And, it can often land an adult in the hospital!) There is one special case of possible vaccine susceptibility that made headlines last year and became a major new focus for those who claim vaccines cause autism. A 19-month-old child developed autism after getting 5 shots. But – and this is a huge "but" – unlike most autistic kids, this one child also has a rare medical problem – Mitochondrial Disease (MD). Recently, vaccine avoiders have floated the theory that perhaps many healthy looking kids have hidden MD. They suggest that it may be the combination of vaccines plus hidden MD that is triggering autism in so many seemingly normal children. But, the research suggests that this is unlikely to affect more than a handful of kids. Here's why: MD is rare (1 in 5-10,000 children). A Portuguese study found ~93% of autistic children had no evidence of MD (and even that 7% figure has yet to be confirmed). In a recent study, scientists from Harvard and Johns Hopkins could find only 25 children with both MD and autism. And, these kids had serious problems rarely seen in most cases of autism (like, delayed walking, acid reflux, liver disorder, severe fatigue, etc). Fourteen of these kids seemed to be developing normally then suddenly deteriorated into autism during toddlerhood. But only 1/14 (7%) got worse right after shots. (Had 2 or 3 or 5 kids gotten worse after the shots, one could make the argument that children with MD are at increased risk for getting autism after vaccinations. However, as I mentioned in part 1 of this blog, 7% is very close to the number of cases one would expect to be diagnosed right after shots…just by chance.) Another dramatic finding of this study argues against a link between MD and the national rise in autism incidence: classic autism spectrum disorder affects many more boys than girls (3-9 times more boys!)…but children with Mitochondrial Disease + autism are evenly split between the genders. While it remains to be proven that children with MD are more vulnerable to shots, there is no doubt that they are super-vulnerable to illness. In other words, MD kids who skip shots can get very sick, very fast it they catch a vaccine preventable disease like influenza or pneumonia. 3) Doctors push risky shots on children to make more money. Please! This accusation is as appalling as it is ridiculous. Pediatricians labor through 23 years of education; wake at all hours to help worried parents; and desert our own families on weekends and holidays to rush to the hospital to care for sick babies. In fact, a greedy doctor wanting more money would actually discourage parents from giving their children shots…not encourage it! Why? Because doctors make more money caring for sick kids – needing repeat office visits – than caring for the well. In truth, the only reason doctors cajole, beg and pressure parents to immunize their children is because we want to protect them – and other children – from the pain and suffering of preventable infections. I agree that there are too many ties between doctors and big pharmaceutical companies. This must be stopped because it creates the appearance of conflict of interest and the real potential of collusion. However, the record of organized medicine is reassuring. Over the past 30 years, doctors have rejected many vaccines when concerns arose that they were not effective enough or caused unacceptable side effects. 4) Shots can be delayed. MAYBE…but only those risking your child's health. This is one of the most critical issues facing parents: Are shots a personal choice or a civic duty? As a pediatrician, I recommend all vaccines, but I suggest parents think of shots as falling into 2 different groups: 1) those given primarily to protect your child, 2) those protecting your child and your neighbors' children. The first group of shots stops infections like, influenza, rotavirus, hepatitis A, chicken pox and hepatitis B. They help your child but don't give great protection to the community. That is either because the illnesses are very common (spread quickly through your neighborhood even if your child gets the shot) or hard to spread (difficult for your child to give it to others). (Note: Older kids, teens and adults are at risk for hepatitis B. It has caused thousands of cases of liver failure and cancer and so all citizens should eventually get this vaccine.) The second group of shots stops infections that threaten your child and your community (your neighbor's baby, the elderly, chronic disease sufferers, etc.). These shots include, whooping cough, meningitis (Hib), pneumococcus (Prevnar) and measles. They miraculously halt diseases that are so contagious just one cough, one airplane flight or one germy doorknob can spread them like wildfire through your town. I believe giving the first group of shots is a parent's personal choice because the suffering you risk is mostly limited to your child and family. Skipping the flu shot, for example, may cause your child to be one of the 36,000 Americans who die from influenza this year, but it probably won't stop a flu outbreak (although it may help to reduce it). However, giving the second group of shots is an important civic responsibility., because delaying them creates a serious public health risk. By immunizing at least 95% of children with these shots we create "herd immunity" that can totally halt the spread of deadly epidemics in our communities. Herd immunity stymies the spread of disease the way that frequent rain keeps lightening strikes from starting raging forest fires. Some doctors may fairly argue which vaccines should go into which groups, but the important point is that the shot schedule has some flexibility…it is not written in stone. In fact doctors have repeatedly tweaked this schedule to make it safer and more effective (for example, over the past 30 years, the measles vaccine was pushed from 9 months to 12 months…and now is recommended to be given as late as 15 months of age). However, the second group of vaccines is crucial if we are to protect children in our communities who are too young to get their own shots. Parents who skip these shots may not mean to harm others, but their action significantly increases the risk of avoidable suffering and death to innocent children. For over 10 years, a huge amount of passion and debate about the cause of autism has focused on vaccines. But recently a totally new suspect has surfaced that warrants investigation as a potential autism trigger. In the last installment of this 3-part blog, I'll discuss the worrisome compounds known as…endocrine disrupting chemicals (EDCs). Part 1: Vaccines and Autism: A Proven Trigger or A Terrible Coincidence Part 3: Toxic Chemicals, A Serious Suspect in the Autism Outbreak. Originally posted on June 23, 2009, at www.huffingtonpost.com By BVA Development