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Founded in 1869 from the wreckage of the Habsburg Empire (after their victory and subsequent collapse in the Austro-Prussian war), the Empire of the Germans is the largest state entirely in Continental Europe, the world's third largest economy, and second most military power. Under the rule of Kaisers Franz Josef, Franz Ferdinand and Charles, it has seen a period of peace, stability and military build-up, however, as far as the 1940's (where this timeline stands) it is held in ill favour by the other Great Powers (the British Empire, France, the USA, etc) as a dangerous threat.
Culturally, Germany has not modernised to the extent of the other Powers, and has remained highly reactionary, with a large military (100 divisions, 50 active and ready for war, 50 reserve, or about 1.80 million men) and increasingly sizeable navy - with no WW1 to derail ambitions of sea-power, the dreadnought and latterly battleship race is intensifying , as they try to beat the british at their own game - for all the power of the Reich, they still feel cheated by France's vast empire, and feel they ought to rule alone.
A unique military arm of the German Army is the Zeppelin fleet - Germany is still the world leader in these massive flying machines, and the only nation to apply them to a military capacity. The absence of any Hindenburg-style disaster in this timeline increased German air-ship production, with 107 Zeppelins and 250 balloon detachments currently in service in the Fleet, mostly of the bomber vareity, but rumours of the time indicate the Germans are developing artillery gun-carrying Zeppelins, which could shell cities from above, but this wildly ambitious project is unverified.
Overseas, Germany, by joining the Scramble for Africa under various leaders, latterly and notably Von Lettow-Vorbeck, has partially assembled Mittelafrika from a few of the territories that OTL would be Belgian or French, but in this extended colonial age is looking increasingly threateningly at Portugal, making African diplomacy (Britain, the largest and strongest World Power, being an ally) decidedly strained. They remain the smallest of the colonial powers beyong Portugal, buut are possessed of a vicious will to expand - politically, it is much like the start of WW1 OTL, but the stakes are much, much higher.


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|P.C. Sadler
|First appearance
|6th January 1975
|Number of appearances
|Played by
|David Roper
P.C. Sadler was the policeman who caught up with Eddie Yeats at Bet Lynch's flat when he skipped parole from Walton Jail at Christmas 1974. He interrupted Bet and Eddie before they began their (long-delayed) night of passion and also noticed several tins of ham in the flat that he correctly deduced were from a supermarket robbery that took place on Christmas Day (Eddie hadn't taken part in the robbery but the gang, led by Big Arthur, landed the goods on Eddie for safekeeping). A disgusted Bet told the policeman to take her would-be lover away.

subset: commoncrawl


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"If you are going to do it, make sure you take a spare pair of trousers" - that was the advice given by one of the brave souls who took on the stomach-churning trail at this year's Scream Factory.
The sound of blood curdling screams echoed through the grounds of Kirkleatham, near Redcar, as guests came face-to-face with some creepy characters at the 2015 Halloween Extreme Tour .
The first to escape the 40 minutes of hell - of which only five minutes are shown in the Gazette's video - was 19-year-old Jenny Youll from Linthorpe.
"It's not for the faint-hearted, that's for sure," she said, as she tried to catch her breath.
"It was scary, you can't see a thing in front of you which doesn't help. But it was brilliant."
What Halloween events are taking place near you? Find out here
Mum-of-four Natasha Tuneridge, from Redcar, was next to emerge from the "fun house" looking rather dazed.
"Oh my God," the 29-year-old screamed.
"I don't think I've been that scared in my life. You definitely need a spare pair of pants if you are going to go in. I need a drink!"
Eston couple Gill and Richard Halliday were out next and even said they would do it again.
"It was horrifyingly brilliant," said Gill, 58.
"I would definitely go back round. It's fantastic, like something you would see in America."
This year, Imaginative Productions, the business behind the attraction, if once again offering people to take a trip down a dilapidated mineshaft, cannibal butchers terrace and the zombie graveyard.
A trailer (above) for the 2015 Scream Factory tour
New attractions have also been created, including the haunted mortuary and the twisted cinema.
The Scream Factory Teesside team have been hard at work since May building and preparing for Halloween.
Appealing to families of all ages, the event this year is promised to be the biggest and best to date.
Guests can choose the Twilight Tour - designed for younger guests and adults to enjoy a lights-on gentle meander through the attraction.
Youngsters will also have the opportunity to 'Trick or Treat' live actors costumed as some familiar friendly characters.
The event is on at the Old Nursery Site, in Kirkleatham Museum, until Saturday.
Tickets range from £5 to £15, depending on the type of tour.
For more information, click here .


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Pixie Hollow
January 16, 2011 by Post Team
Pixie Hollow, Journey into the secret world of Pixie Hollow and hear Tinker Bell speak for the first time as the astonishing story of Disney's most famous fairy is finally revealed in the brand new animated TinkerBell. Have you ever wondered where nature gets its glow from whom nature gives light and color as the seasons come and go? Enter a land of adventure and mystery as Tinker Bell and her four best friends in winter, spring change. They learn the power of faith, trust and a little fairy dust, how important it is to remain true to yourself. Tinkerbell does the beloved fairy and her first animated movie, full of fun and fantasy.
Disney closed cartoons for preview : "Pixie Hollow's Game Preview is currently closed. "
"We'll be open again soon!
Thank you for your patience!"
Please feel free to send if you have any questions regarding this post , you can contact on
Disclaimer: The views expressed on this site are that of the authors and not necessarily that of U.S.S.POST.


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Hermaphrodite Angela Summers Surprises 2 Women
Duration: 12min 31sec Views: 26 157 Submitted: 1 year ago Submitted by:
Description: 2 women wonder what it'd be like to fuck a girl like a guy and Angela Summer whips out her cock and shows them what it's like. Uploaded again because the title was misspelled and I could not edit it.
Tags: Hermaphrodite Tourist Jock


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There's this story we clergy tell religiously around this time every year.Not the thing about the Last Supper. Not the cross, and the empty tomb. I mean, those are good too, but we have this other one that is really our favorite. It's this story about how BUSY we are; how long the list of details, how impossible the expectations, and how exhausted we are just thinking about it.Stop me if you've heard it.Where did we learn that story? I believed for a long time that it was in one of … [Read more...]
The Stories We Tell Ourselves: Holy Week Clergy Burnout
Don't Like Your Pastor? Don't Leave Your Church
There's a blog post going around called "So You Don't Like your Pastor..." I read it. And it wasn't about what I thought it was going to be about.First of all, it was written from a completely male perspective. Not just written by a man, but written as though only men exist in the world, ever. You know how those things go... But the article was about clergy burn-out, the unique stresses of pastoral life, and how church members should have empathy for their pastors... Understanding that m … [Read more...]
Cleaning the Brushes: The Never-Done Work of Ministry
My friend Kory shares some thoughts on the "never done-ness" of ministry. On behalf of pastors everywhere, I say, "amen, brother."I helped my neighbor stain his pool deck this weekend. I wish I could tell you I did this Mother Theresa-style, all selfless and void of any agenda. But in all honesty, I had two motivations: (1) he helped me stain my deck last year, and (2) I want to stay in his good graces so my family and I have an all-access pass to use his pool.It took us about four … [Read more...]
Talking to Strangers: Scene in a Bar
I was drinking a beer. That was her first clue that I wasn't a real Christian.When she asked me what I did and I mentioned that I was a pastor, I'm guessing that sealed the deal.So when she asked me to tell her about my church, I could have quoted our denomination's identity statement, keeping it light and generic. Or I could have told her about youth group and women's ministries and mission work in El Salvador. But I figured I was already batting zero—drinking a beer AND being a lady min … [Read more...]
Cloud By Day: Living With Ambiguity and Measuring Ministry
In every generation, people of faith journey across the hazy plains of "What does this mean," and "why are we here?" Right about the time one band of believers establishes a clear sense of purpose and identity for their time and place…well, they die. It is time for them to step aside and let the kids figure out what's next, with nothing but "a pillar of cloud by day, and a pillar of fire by night" to guide them. And is that ever a painful hand-off, every single time.We can wax poetic and … [Read more...]
Good Call: 10 Ways to Nail that Pastoral Search Interview
It's that time again. All over the country, exhausted pastoral search committees plow through another pile of profiles, fumble with the technology for another round of Skype interviews, and miss another week of family dinner times to make a series of reference-check phone calls. Meanwhile, pastors sit anxiously by the phone, like they are waiting for the daggone quarterback to call on a Friday night, just hoping for that next small sign of hope: "we are moving ahead in our selection process, and … [Read more...]
Holy Week Survival Guide: 10 Life Hacks for Clergy
Deep breath. Inward Ommmmmmmmmmmm. It is Holy Week! Lace up your sprinting shoes, get ready to stress eat and drink way too much coffee, and tell your family that you will see them next Monday. No wait—Monday, you hibernate. Tuesday, for sure! You will be down for breakfast on Tuesday. Or at least lunch… Something about that pattern seems not-so-holy, though. Sure, it's going to be busy. You will need caffeine and adrenaline and the Holy Spirit to power through. And yet… we clergy types often w … [Read more...]
Talking to Strangers
It was Sunday morning. I stopped at my favorite, may or may not have chosen my new house based on proximity to this place, donut joint to buy a couple dozen for our new member class. (I win souls for the Lord with vanilla glazed and pumpkin spice varieties).It was early. Still dark out. There was one other person in the place, and I mean, she looked normal enough… She was being pretty chatty with the register girl, so I jumped into the conversation. Because hey, it's Sunday morning, there's a … [Read more...]
How to Do It All
Sometimes other clergy ask for advice on how to balance being a pastor and a parent. So here, I'm going to give you 10 never-fail secrets to getting it all right at church and at home, keeping up your self-care and personal appearance, while having a smile on your face at all times.Lol, people. L.O.L.The truth is, there is no such list, and if anybody tells you they have one, they're a lying *#%&^$#@!. When people ask how I do it, I answer, "sometimes, not very well." And that's the d … [Read more...]


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TY - JOUR T1 - Digital soil mapping in the absence of field training data: A case study using terrain attributes and semiautomated soil signature derivation to distinguish ecological potential JF - Applied and Environmental Soil Science Y1 - 2011 A1 - Browning, D.M. A1 - Duniway, Michael C. KW - JRN AB - Spatially-explicit data for soil properties governing plant water availability are needed to understand mechanisms influencing plant species distributions and predict plant responses to changing climate. This is especially important for arid and semi-arid regions. Spatial data representing surrogates for soil forming factors are becoming widely available (e.g. spectral and terrain layers). However, field-based training data remain a limiting factor, particularly across remote and extensive drylands. We present a method to map soils with Landsat ETM+ imagery and high resolution (5 m) terrain (IFSAR) data based on statistical properties of the input data layers that do not rely on field training data. We then characterize soil classes mapped using this semi-automated technique. The method distinguished spectrally distinct soil classes that differed in subsurface rather than surface properties. Field evaluations of the soil classification in conjunction with analysis of long-term vegetation dynamics indicate the approach was successful in mapping areas with similar soil properties and ecological potential. VL - 2001 UR - bibliography/11-006.pdf IS - Article ID 421904 ER - TY - JOUR T1 - Protection from livestock fails to deter shrub proliferation in a desert landscape with a history of heavy grazing JF - Ecological Applications Y1 - 2011 A1 - Browning, D.M. A1 - Archer, S. R. KW - JRN KW - woody biomass AB -
Desertification is often characterized by the replacement of mesophytic grasses with xerophytic shrubs. Livestock grazing is considered a key driver of shrub encroachment, although most evidence is anecdotal or confounded by other factors. Mapping of velvet mesquite (Prosopis velutina) shrubs in and out of exclosures in 1932, 1948, and 2006 in semiarid grasslands of southeastern Arizona, USA, afforded the opportunity to quantify livestock grazing effects on mesquite proliferation over 74 years in the absence of fire to test the widespread assumption that livestock grazing promotes shrub proliferation. In 1932, shrub cover, density, and aboveground biomass were compared on grazed (12%, 173 plants/ha, 4182 kg/ha) and newly protected areas (8%, 203 plants/ha, 3119 kg/ha). By 1948, cover on both areas increased to 18%; yet, density on the protected area increased 300% (to 620 plants/ha), nearly twice that of the grazed area (325 plants/ha). From 1932 to 1948, differences in recruitment of new plants and growth of existing plants were reflected in biomass, which was higher on the protected area (415 plants/ha, 8788 kg/ha) relative to the grazed area (155 plants/ha, 7085 kg/ha), although mortality was equally low (0.06%). In 2006, 42 years after an herbicide application reset mesquite cover to 10% on both areas, aboveground mesquite mass was comparable on both areas (4700 kg/ha), but cover and density on the protected area (22%, 960 plants/ha) exceeded that on the grazed area (15%, 433 plants/ha). Mesquite mass in 2006 was substantially below 1948 levels, so continued accrual is likely. That shrub recovery from herbicides on a biomass basis was much less than recovery on a cover basis suggests that remotely sensed biomass estimates should integrate land management history. Contrary to widely held assumptions, protection from livestock since 1932 not only failed to deter woody-plant proliferation, but actually promoted it relative to grazed areas. Results suggest (1) that thresholds for grassland resistance to shrub encroachment had been crossed by the 1930s, and (2) fire management rather than grazing management may be key to maintaining grassland physiognomy in this bioclimatic region.VL - 21 UR - bibliography/11-014.pdf IS - 5 ER - TY - JOUR T1 - Temporal dynamics of shrub proliferation: Linking patches to landscapes JF - International Journal of Geographical Information Science Y1 - 2011 A1 - Browning, D.M. A1 - Laliberte, A.S. A1 - Rango, A KW - JRN KW - shrub encroachment AB -
Shifts in vegetation composition and cover are generally characterized by processes acting at different levels such as landscapes, hill slopes, or plant interspaces. Object-oriented analytical approaches are based upon the inherently hierarchical nature of complex systems and are well-suited to research applications conducted at a range of spatial scales. We quantified long-term vegetation dynamics from two perspectives (i.e., landscape and vegetation patches) in a Chihuahuan Desert ecosystem in southern New Mexico, U.S.A. from 1937 to 2008. Our multi-scale approach comprised object-based analysis of time series aerial photography with automated image analysis at the landscape scale and manual delineation of shrub image objects at the patch scale. We sought to identify mechanisms associated with changes in shrub patch density and percent cover by classifying the fate of individual shrub patches from one image to the next in the time series. The classification scheme captured colonization by new shrub patches, growth or decline in patch area, and patch stability (i.e., change in size of less than 15%). Patch growth was categorized as growth by coalescence with neighboring patches or canopy expansion. Similarly, patch decline was distinguished as either loss of patch area due to fragmentation of conglomerate patches or canopy die-back. Interpretations of change in patch density based solely on shrub establishment and mortality can be too simplistic. Increases in patch density can result from an influx of new patches or fragmentation of patches into its constituent patches; conversely, decreases in density may be due to mortality of patches or coalescence of existing patches. We illustrate that patches grew in size at the beginning of the study period in conjunction with increases in shrub cover (0.5% in 1937 to 11% in 1960) and patch density (4 patches ha-1 in 1937 to 80 patches ha-1 in 1960) increased during the initial encroachment phase of shrub proliferation. Shrub cover remained stable at 7% from 1967 to 1989 and over this period, patch dynamics were broadly characterized by maintenance of patch area with roughly equal proportions of mortality and establishment. Shrub cover increased linearly from 8% in 1989 to 14% in 2008, approaching a maximum projected shrub cover of 18% based on mean annual precipitation of 230 mm from Sankaran et al. (2005). Shrub patch fate over this period constituted growth and maintenance of patch area whereas appearance of new patches remained relatively stable. Patch dynamics signify a shifting mosaic in which shrub patch establishment, growth, and mortality wax and wane. Monitoring patch dynamics will become increasingly important in these actively managed ecosystems as broad-scale measures of percent cover approach and fluctuate about a dynamic equilibrium.VL - 25 UR - bibliography/11-020.pdf IS - 6 ER - TY - JOUR T1 - Hierarchical object-based classification of ultra-high-resolution digital mapping camera (DMC) imagery for rangeland monitoring and assessment JF - Journal of Spatial Science Y1 - 2010 A1 - Laliberte, A.S. A1 - Browning, D.M. A1 - Herrick, J. E. A1 - Gronemeyer, P. KW - JRN KW - very high resolution AB - Ultra high resolution digital aerial photography has great potential to complement or replace ground measurements of vegetation cover for rangeland monitoring and assessment. We investigated object-based image analysis (OBIA) techniques for classifying vegetation in southwestern U.S. arid rangelands with 4 cm resolution digital aerial photography. We obtained high r-square values for image- and ground-based measures of percent cover (r-square values: 0.82-0.92). OBIA enabled us to automate the classification process and demonstrated potential for quantifying fine-scale land cover attributes with ultra high resolution imagery. This approach exhibits promise for nationwide application for monitoring grazing lands. VL - 55 UR - bibliography/10-023.pdf IS - 1 ER - TY - JOUR T1 - Field validation of 1930s aerial photography: What are we missing? JF - Journal of Arid Environments Y1 - 2009 A1 - Browning, D.M. A1 - Archer, S. R. A1 - Byrne, A.T. KW - JRN KW - sonoran desert AB - Aerial photography from the 1930s serves as the earliest synoptic depiction of vegetation cover. We generated a spatially explicit database of shrub (Prosopis velutina) stand structure within two 1.8 ha field plots established in 1932 to address two questions: (1) What are the detection limits of panchromatic 1936 aerial photography?, and (2) How do these influence P. velutina biomass estimates? Shrub polygons were manually digitized on 1936 imagery and linked to 1932 field measurements of P. velutina canopy area. Aboveground 1932 P. velutina biomass was estimated using a site-specific allometric relationship for field-measured canopy area. Shrub canopy detection limits on the 1936 imagery were comparable to those reported for contemporary imagery. Based on a conservative shrub size detection threshold of 3.8 m2, 5.8% of P. velutina biomass was missed. Spatial resolution (0.6 vs. 1.0 m) did not influence detection limits, but the overall accuracy of shrub cover estimates was greater on 1.0 m images. Presence of the sub-shrub Isocoma tenuisecta may also have significantly influenced estimates of P. velutina canopy area. These analyses illustrate the importance of standardizing aerial photo interpretation protocols, accounting for uncertainty estimating shrub biomass, and caution species-specific interpretations for historic aerial photography. VL - 73 UR - bibliography/09-019.pdf ER - TY - JOUR T1 - Unmanned aerial vehicle-based remote sensing for rangeland assessment, monitoring, and management JF - Journal of Applied Remote Sensing Y1 - 2009 A1 - Rango, A A1 - Laliberte, A. A1 - Herrick, J. E. A1 - Winters, C. A1 - Havstad, KM A1 - Steele, C. A1 - Browning, D.M. KW - JRN KW - small KW - unmanned aerial vehicles AB - Rangeland comprises as much as 70% of the Earth's land surface area. Much of this vast space is in very remote areas that are expensive and often impossible to access on the ground. Unmanned Aerial Vehicles (UAVs) have great potential for rangeland management. UAVs have several advantages over satellites and piloted aircraft: they can be deployed quickly and repeatedly; they are less costly and safer than piloted aircraft; they are flexible in terms of flying height and timing of missions; and they can obtain imagery at sub-decimeter resolution. This hyperspatial imagery allows for quantification of plant cover, composition, and structure at multiple spatial scales. Our experiments have shown that this capability, from an off-the-shelf mini-UAV, is directly applicable to operational agency needs for measuring and monitoring. For use by operational agencies to carry out their mandated responsibilities, various requirements must be met: an affordable and reliable platform; a capability for autonomous, low altitude flights; takeoff and landing in small areas surrounded by rugged terrain; and an easily applied data analysis methodology. A number of image processing and orthorectification challenges have been or are currently being addressed, but the potential to depict the land surface commensurate with field data perspectives across broader spatial extents is unrivaled. VL - 3 UR - bibliography/09-025.pdf ER -


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|Print edition News
Page 2A
Richardson says he may not win but will do well
Candidate hopes to build on appeal as Western leader
By Martha T. Moore
SPARKS, Nev. � New Mexico Gov. Bill Richardson has run a state, served in a president's Cabinet and gone around the globe solving diplomatic crises, but on a recent afternoon at a farmer's market street fair, the Democrat is having a hard time convincing people he's making a White House bid.
"I'm running for president," Richardson, 59, tells two women passing by, and their reaction is laughter. "Look at all the photographers!" he exclaims, waving at the small pack of press trailing him. "You don't believe me!"
Maybe it's his attire of black T-shirt and jeans or his inconspicuous security detail. A day later, in rural Elko, his staff pulls out all the stops for a crowd of about 150 people. There's a stage, a lectern a riser for TV cameras, and an anteroom made with those bright blue draperies that signify "major political appearance."
Richardson's support has climbed in Nevada, Iowa and New Hampshire, where early nominating contests can propel a presidential hopeful to front-runner. But he remains far behind Hillary Rodham Clinton, Barack Obama and John Edwards, who lead national and state polls for the Democratic nomination.
In Nevada, Richardson hopes he has special appeal. "I am a Western governor, I know about Western issues" such as water and federal land management, he says. And, like nearly a quarter of Nevadans, he is Hispanic � though he tells a local TV crew, "With a name like Richardson, it's hard to get people to believe that."
"I'm not predicting victory, I'm predicting a strong showing," Richardson tells USA TODAY.
First he has to walk the farmer's market, which quickly becomes a run through the issues gantlet. Does he support gay marriage? asks Natasha DeLucia, a student working at a crafts booth with her girlfriend. Only civil unions, Richardson says. "Health care is eating us out of house and home," says Cheryl Huett, who owns a lemonade company. Richardson tells her he wants a refundable tax credit people can use to buy health insurance.
"Will you keep Bush's tax cuts?" asks Michelle Webb, a supermarket checker. No, Richardson says, "I'd replace them with a middle-class tax cut." So much for getting Webb's vote: A Republican, she says she's not happy with Richardson's record on taxes or immigration in New Mexico, and the Bush tax cuts "helped me out a lot." Bottom line, Webb says, "I wasn't bowled over."
On the campaign trail, Richardson's rumpled charm and love of shaking hands � he claims the world record for doing so � serve him well. Like his old boss Bill Clinton, he wrestles not only with an appetite for food but tendencies to run late and to run on. And on.
In an era of rigorous adherence to talking points, Richardson doesn't give the same speech twice. He covers Iraq, energy policy, a "hero's health card" for veterans, the need for more gym classes in schools, balancing the budget and more. He suggests an "Apollo-like program" to develop energy technology, and a "massive federal program" for arts education. The joke that ends one speech with a laugh � about his wife, Barbara, noting his gubernatorial approval rating is sky-high because he's been out-of-state campaigning � comes two-thirds of the way through another.
He covers a lot of territory, Richardson says, because "this country needs a lot of change in a lot of areas."
Immigration doesn't always get mentioned without prompting. Nor does he detail his tax policy or how to finance proposals such as college scholarships for all students. Tim Russert of NBC's Meet the Press criticized Richardson during an interview in May for first supporting and then opposing a congressional immigration bill and for first supporting and now opposing the war in Iraq.
"You've got to expect to be scrutinized in a job like this," Richardson says. "I fully admit that my thinking's evolving, that I haven't gotten my shtick down."
Voters respond to Richardson's diplomatic experience, gained as Clinton's ambassador to the United Nations and as an envoy sent to negotiate with hostile regimes.
"I see him as someone who would bring us together," says Las Vegas middle-school teacher Barbara Shapiro, who praised Richardson's "ability to negotiate, and not see the rest of the world as an enemy but as a partner."
On domestic policy, the Democratic candidates "aren't that far apart," says John Scire, a Reno political science professor. He says Richardson's international experience means "he's not going to do anything to hurt this country, like this blundering in Iraq."
Others who listen to Richardson come away frustrated.
"I wish he'd addressed what he'd do about the deficit and taxes," says Helen O'Brien, an accountant. "It's easy to say we'll shift over the money from the war."
"How's he going to pay for full health care?" asks her partner Eric Lamberts, a doctor.
The pair heard Richardson speak at a Reno house party but came away still looking for a candidate to support. "He didn't light the fire," Lambert says. "Although, he does have a whole lot of experience."
Page 2A
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CNN New Day host Chris Cuomo said on Monday that just because Michael Brown dealt drugs doesn't mean he was a 'Drug Dealer'.
The Washington Free Beacon reported:
…the creators of the new documentary Stranger Fruit claim they've uncovered new evidence that puts that incident in a different light. Filmmaker Jason Pollock claims surveillance video footage from 1 AM the on day of the shooting proves that Brown didn't steal the cigarillos, but the clerk traded them to him in exchange for marijuana. Pollock alleges Brown was just collecting on the deal later on in the day.
"If taken on its face as purported in the documentary, it would go to the suggestion that Mike Brown wasn't there to steal, he was there to do a transaction which may or may not have been legal," Cuomo reported.
CNN law enforcement analyst Harry Houck responded that it all amounted to the same.
"It still shows him as a drug dealer anyway if it's true," he said.
"How?" asked Cuomo.
Cuomo's resistance to the idea seemed to take Houck aback.
"Well, Mr. Pollock basically said that he was giving marijuana to the [clerk] for cigarillos," Houck said.
"That doesn't make him a drug dealer," Cuomo said, stressing the last word.
"It's a drug deal Chris, it's a drug deal," insisted the former NYPD detective. "It doesn't matter how it's done. If I give you drugs for something, that's a drug deal, you go to jail."
"Right, but that doesn't make him a drug dealer," Cuomo said, continuing the stress the last word.
With Chris Cuomo's logic someone who kills is not a murder, someone who steals is not a thief, and someone who lies is not a liar.
(Image: YouTube Screenshot)
Follow Ryan Saavedra on Twitter: @RealSaavedra


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|Separate WC's
|Property type
|Minimum Stay
|3 nights
This 3 bedroom town house is in the heart of the Old Village, one of the most attractive and sought-after complexes in Vilamoura. Just 10 to 15 minutes walk from the marina and beach, it is a little community in its own right with restaurants, cafes, shops and bars. Wander around the pretty cobbled streets, enjoy a cool drink at on open air café or take a refreshing dip in any one of the three large swimming pools. There's plenty of room for the kids to stretch their legs with lawned areas and a play ground. The house has lots of home comforts and attractive features including a private roof terrace with sea views. Now installed digital TV with 60 stations ,included all UK & Irish stations, sky sports etc. Also Wifi free included in your rent . Recently added barbeque on the roof terrace for evening dining with view across the Marina.
Also new children's playground & small outdoor gymnasium area.
Scuttle bus from the Old Village to Falesa Beach , The Marina , & other popular locations in the area .
Also tours organised to local historical sights & shopping centres etc .
NB -- November 2015-- Our house is currently being totally redecorated & refreshed for 2016 season.
We are an Irish couple with an adult family & grandchildren.
We spend 5/6 weeks every year in The Old Village
cecil clegg purchased this house in 2007
We searched around France ,Spain & Portugal for a holiday home.
When we were shown the Old Village we decided this was the place for us, with its unique buildings & beautiful gardens.
It is very peaceful for relaxing holidays.
Brilliant family holiday area .
Beautifully maintained with flowers .
24 hour security , no late night rowdyism allowed .
No cars allowed in the Old village -- so very safe for children.
New bus service To Vilamoura , Quateira & to the beach.
Schuttle service in Old Village available for airport transfers etc or other outings.
Contact -- Email - firstname.lastname@example.com.
Telephone - 00351 961260000
Also road train travels around Vilamoura ,with drop off points .
We used the property as the base for our daughters wedding. It was superb. We couldn't fault it.
Only slight snag was that it was the hottest September since 1930, and the garden sun umbrella was broken and we couldn't use it. A very minor point and easily fixed.
We have no hesitation in recommending this property.
Just come back from this beautiful apartment. Very well equipped and an excellent location. Would recommend staying here to anyone.
This is a fantastic house on a beautiful complex. It was bigger than we had imagined with a very homely feel. It had everything that you could possibly need on holiday expect a wardobe full of clothes!! From a bucket and spade to a library of books. The property was clean and well maintained.
Communication with the owner of the property was done via email, who was very prompt at answering any queries and providing information regarding our stay. The company who manage the property in The Old Village are extremely helpful and speak very good English.
The complex is extremely well kept with beautifully coloured flowers and trees everywhere. There are a range of restaurants and bars to suit all and serving all day. There are 3 pools, also catering for different levels of entertainment. The quietest of which is closest to this property.
I would recommend this property and complex to families, couples, old and young as it is a wonderful base to explore the beautiful Algarve or just relax around the Village.
Vilamoura Marina is a 'good' walk from this property, however, there is a little train that circulates Vilamoura which comes every 20mins (approx) and costs about €4, and an excellent taxi service just at reception.
Loved it here, we will definately be back, however, not likely in August as the temperature was alot for us (personal preference) but the air-con was wonderful and the wine was cold!
5 stars from our family!!
We had a fantastic holiday in this lovely townhouse in the old village. We are a family of 5 with 3 kids under 7 this house was perfect for us it was really well equipped. Everything we needed was there when we arrived cot, stair gate. The air con in the bedrooms was fantastic as it was really hot when we were there. The shuttle service from the old village is an excellent service the cars could fit us all and had baby seats/boosters and the staff were so nice and friendly. The supermarket was well stocked all of the time. Thank you Cecil for letting us stay in your lovely holiday house and for being so helpful from our first enquiry and right through our booking we would definitely recommend this lovely house and we will hopefully be back again !
We had a fantastic time. Great location. The old village is lovely and well located for a 20 minute walk to the marina. The house is lovely and clean only hiccup was the broken air con in main bedroom replaced quickly after we arrived. Also a bar of soap would have been nice as the three toilets had none at all so made washing hands a tad difficult on arrival. Had to quickly send one of my boys to the on site small supermarket.
Loved the restaurants in the old village although la rendezvous is disappointing for children with very limited choice. 3 pools to choose from although amusing watching the queues form from 9am at the pool gates to get the sunbeds.
Marufo 1 aka chicken shack near quarteira is to die for for family dining both in quality and cost. Sit and eat with locals. The family golf On way to the marina is superb and has two 18 hole crazy golf courses with shade parasols that disperse water mist to keep you cool. Hope to return soon.
15 minute walk to the Marina. 20 to the beach. For 5 euros you can get a ride. Everything you need is in the old village - supermarket, breakfast cafe, restaurants. This unit is 20 steps away from the Princess Garden Restaurant which was wonderful. Accommodations were simple - uncomfortable beds - but fine for a family stay. Open the windows and doors and there is no need for air conditioning.
The Algarve is renowned for its golden sandy beaches and when you stay at this house they are within easy reach. It is 5 minutes drive to the nearest beach or you could walk there in around 15 minutes. Vilamoura has two beaches and both have lifeguards (in summer season- please check before you go in the water) local cafes and sun loungers to hire. There are also water sports from parasailing to jet skis on offer at local beaches.
It is about 25 minutes drive from Faro airport. We can arrange airport transfers. Car hire is not essential as there are cafes and shops on site and it is just a short walk to the centre of Vilamoura.
Vilamoura 10 minute walk.( 1 mile approx )
Quateira 30 minute walk (3 miles approx)
Faro 15 miles approx
Guia shopping centre 20 miles approx
Further Details:
The Old Village is an ideal location for relaxing sunshine and family holidays as everything you need is on site and car hire is not necessary. There are a number of good cafes and restaurants serving Portuguese and international cuisine, snacks and drinks including Casa do Largo, Zanzibar, Princess Gardens, the Village Inn, Bar Nautica, Sports bar and O Cafe. There is also a small supermarket and off-license. The onsite security is good so you can just relax and enjoy your holiday. Vilamoura is one of the largest privately owned resorts in Europe so you can be sure of enjoying first class amenities in pleasant surroundings. Its six world class golf courses draw golfers from across the globe and its marina gleams with state-of-the-art yachts. During the day the marina is a popular place to shop and watch the world go by. One day why not take to the water with scenic boat trips, dolphin watching, sea fishing, parasailing, jet skiis, scuba diving and much more on offer? If you prefer to keep your feet on dry land, Vilamoura is an idea base for exploring the Algarve's historical towns, villages and markets and the tranquil countryside is popular with horse-riders, cyclists and walkers. At night Vilamoura's bars, restaurants and casino really come to life with entertainment to suit every taste. Portugal is justifiably famous for its fine food and wine with fresh seafood a speciality and you'll find lots to tickle your taste buds in Vilamoura's many excellent Portuguese and international restaurants.
|Rental Period
|Minimum Price
|Additional Nights
|Weekend Night
|Event Price
15 Jul 2017 - 31 Aug 2017
3 night minimum stay
for 3 nights
1 Sep 2017 - 15 Sep 2017
3 night minimum stay
for 3 nights
16 Sep 2017 - 30 Sep 2017
3 night minimum stay
for 3 nights
1 Oct 2017 - 31 Oct 2017
3 night minimum stay
for 3 nights
|No additional mandatory fees
Booking Notes:
We require a 30% deposit on booking with the balance payable 8 weeks before your arrival. £200/250 euros security and breakages deposit.
Changeover Day:
Changeover days are flexible. Check in time is 3pm, check out is 10am.
Notes on prices:
Prices are for the property per week in uk sterling.


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Thursdays at ONE80 Grey Goose Lounge: Feat DJ Ghostrider
T Gaines x Joey Womack
Thursday, March 13, 2014 at 10:00 PM - Friday, March 14, 2014 at 2:00 AM (EDT)
VIP Table/Group Accommodations (4+ people): Dexter Williams at firstname.lastname@example.com / 786.505.3593
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+ Grey Goose Thursdays
+ Thursday, March 6th | 10pm to 2am
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+ R&B with a Hint of Hip Hop by a Rotation of Orlando's Best Deejays
Dress Code: Amazing (Nice Jeans Are Allowed)
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Posted on - Tags: cart visit for dj, background dj image for visiting card, new dj hd visiting card, free psd dj business cards
50+ Dj Music Business Cards & Designs
- Published by
Djs are real cool they let friends together with night parties. DJs or anyone related to music industry needs special attractive business card designs appropriate for their work or business. Inspirational designs can pull... View Article


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Eckhaus Latta's do excess
Eckhaus Latta's latest collection is all about excess.
The label is made up of designers Mike Eckhaus and Zoe Latta. The pair have an unconventional approach to their collections, and their latest offering is no exception.
"I think this collection is about excess, layering things and the rich colours. At the end, we had pleating. Beading is something we've never really worked with before," Mike told harpersbazaar.com. "We wanted to think about what it would be like to create an overall surface in a beaded textile. Would it become decoration or more of an object? Then in the form of a harness, it's like a sea anemone or glass fur. It's fun to explore that language and have it be something you can wear over a t-shirt."
The duo call upon friends and models of all shapes, sizes, gender and ages to walk in their shows. Their creations include coral hued pleated separates, a pale pink glass beaded harness and draped baby blue shifts.
"Things were getting draped in a way that was chaotic," he added. "It was about having things not feel pristine, but not having things feeling deconstructed with a raw hem either."
When it comes to the person they have in mind while designing, Mike reveals it's someone who is very self-assured regardless of what they wear.
"I think we're designing for these people who are not looking to find a brand to find themselves, but they're drawn to clothing because it enhances their being," he said. "They're not trying to prescribe to any particular identity."
Cover Media


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Download the Game Design and Indie Game Marketing Freebook 07/19/17GameDev.net and CRC Press have teamed up to bring a free ebook of content curated from top titles published by CRC Press. The freebook, Practices of Game Design & Indie Game Marketing, includes chapters from The Art of Game Design: A Book of Lenses, A Practical Guide to Indie Game Marketing, and An Architectural Approach to Level Design. The GameDev.net FreeBook is relevant to game designers, developers, and those interested in learning more about the challenges in game development. We know game development can be a tough discipline and business, so we picked several chapters from CRC Press titles that we thought would be of interest to you, the GameDev.net audience, in your journey to design, develop, and market your next game. The free ebook is available through CRC Press by clicking here. The Curated Books The Art of Game Design: A Book of Lenses, Second Edition, by Jesse Schell Presents 100+ sets of questions, or different lenses, for viewing a game's design, encompassing diverse fields such as psychology, architecture, music, film, software engineering, theme park design, mathematics, anthropology, and more. Written by one of the world's top game designers, this book describes the deepest and most fundamental principles of game design, demonstrating how tactics used in board, card, and athletic games also work in video games. It provides practical instruction on creating world-class games that will be played again and again. View it here. A Practical Guide to Indie Game Marketing, by Joel Dreskin Marketing is an essential but too frequently overlooked or minimized component of the release plan for indie games. A Practical Guide to Indie Game Marketing provides you with the tools needed to build visibility and sell your indie games. With special focus on those developers with small budgets and limited staff and resources, this book is packed with tangible recommendations and techniques that you can put to use immediately. As a seasoned professional of the indie game arena, author Joel Dreskin gives you insight into practical, real-world experiences of marketing numerous successful games and also provides stories of the failures. View it here. An Architectural Approach to Level Design This is one of the first books to integrate architectural and spatial design theory with the field of level design. The book presents architectural techniques and theories for level designers to use in their own work. It connects architecture and level design in different ways that address the practical elements of how designers construct space and the experiential elements of how and why humans interact with this space. Throughout the text, readers learn skills for spatial layout, evoking emotion through gamespaces, and creating better levels through architectural theory. View it here. Learn more and download the ebook by clicking here. Did you know? GameDev.net and CRC Press also recently teamed up to bring GDNet+ Members up to a 20% discount on all CRC Press books. Learn more about this and other benefits here.
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About Damian.
Damian. reviewed jsvcycling's article in General and Gameplay Programming
Thanks, guys that helped. I used AdjustWindowRect, and now these lines are gone, and result looks much much better. Thanks again.
Size of backbuffer is the same as window, and model was created in blender (smooth normals), and this model looked great in OpenGL :) I also tried VSync (off/on), didnt help.
Damian. posted a topic in Graphics and GPU ProgrammingSo I started playing with Direct3D11, and everything works fine except bad lines on my screen, its hard to see it on image, but in realtime, when something is rotating, its easy to spot. Thanks for any help. Direct image link: http://screenshu.com/static/uploads/temporary/wi/03/sw/534p3u.jpg
Damian. reviewed Klutzershy's article in General and Gameplay Programming
Damian. replied to striker87's topic in For BeginnersSome people enjoy more in Engine Programming, some other people like Game Programming. For example, I didn't like to make amateur games (games just for portfolio, etc) in Unity, or other engines, If i make something just for fun i like to make it from scratch, but if someone is making games in studio, the best choice is to use Game Engine, its just my little opinion.
Damian. reviewed Alpha_ProgDes's article in General and Gameplay Programming
Damian. replied to phil67rpg's topic in For BeginnersIt should be OK but, if I'm not wrong you need virtual keyword before void's :-)
Damian. replied to CreatorOfThings's topic in For BeginnersIt depends what you want to do in development (Graphics, Programming, etc..) But if you are going for programming, and you want to learn how everything works, then use OpenGL/DX. But if you want to program a Gameplay/AI/ etc.. then use some libraries for example SFML. And of course it also depends in what language you want to program.
Damian. replied to Kripis's topic in For BeginnersWhy don't you try something like this? function meatball() { var h = document.getElementById('hi').value; alert("I love " + h); }
Damian. replied to Vlad Muresan's topic in For BeginnersIf you done some games in past, go for OpenGL, but if not then use frameworks/libs/engines. And the another thing is that, what do you want to do. Games or Engines (If games then stick with engines), but if you want to learn more about 2d/3d graphics, how it works etc, then go for OpenGL.


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Art History Browser \ Early Renaissance Art \ Paolo Veneziano Gallery
Paolo Veneziano (1300-1362) was a medieval painter from Venice.He was born to a family of artists, and worked together with his sons Marco, Luca, and Giovanni. He was official painter of Andrea Dandolo, for whom he painted the Pala Feriale.Paolo is sometimes held to be the Master of the Washington Coronation, although this has been disputed by numerous sources. more from wikipedia »


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About Me
David Balaban is a computer security researcher with over 10 years of experience in malware analysis and antivirus software evaluation. David runs the http://privacy-pc.com project which presents expert opinions on the contemporary information security matters, including social engineering, penetration testing, threat intelligence, online privacy and white hat hacking. As part of his work at Privacy-PC, Mr. Balaban has interviewed such security celebrities as Dave Kennedy, Jay Jacobs and Robert David Steele to get firsthand perspectives on hot InfoSec issues. David has a strong malware troubleshooting background, with the recent focus on ransomware countermeasures.
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28 Jul 2007
Access All Areas: Fanzines to Magazines
While we live in an era where much of the music industry continues to face a tsunami of change … Some things stay pretty much the same! The arrival of a bunch of new free fanzines would suggest that there is still a place for funky street-wise publications. Trevor Reekie talks to editors Tony Nyberg from B Side magazine in Auckland and Patrick Shepherd from Exposure magazine in Wellington about the art and craft of the street press.


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Author of "Her Love Bucket" reveals details of Relationship Design;
and it's generated by
love for you. Here's what this website is all about:
This website is Generated by Love
Do You Know the
What is a Relationship Design Plan?
There is a broad spectrum of Relationship Designs and within it, there are ranges
of values or sets of related qualities. These values and qualities
dominate the specific mate emphasis and there are 9 dominant relationship design specific mates.
You know the saying, "If you fail to plan, you plan to fail." Failing to plan means you have no intention to plan. Relationship design plan has everything to do with your intention to plan - to plan love success.
If you are planning on sharing life with a lifemate it is good idea to plan love success.
Within the relationship design plan is the common goal. Underlying the common goal is intention. Intention is everything. The impact of intention in your choice of relationship design is far reaching. Intention is a course of action that one intends to follow. Intention is an aim that guides action; an objective.
The purpose of an intention is often referred with respect to marriage: honorable intentions. So do you have honorable intentions for your relationship design plan? Is it all about you or are your really coming together to share a life with a common goal.
Purpose strengthens the idea of resolution or determination: "Her purpose was to discover if her boyfriend intended to commit to the relationship long term or keep things casual."
The common goal suggests an idealistic or long-term purpose: The lovers embarked on their love journey goal to travel the world while raising a family and home-schooling the children.
The objective of the relationship design plan often implies that the common goal can be reached: The couple's actions clearly followed the premeditated objective of their common goal of being 'adventure' mates.
Everybody Loves Love® (and Sex)
Everybody loves love. Because there is such an intense primal urge of men and women to mate, and men's sex drive area in the brain is 2.5 times larger than women's, sex is major driver in humans. So just keep everyone happy and aroused, SEX is the RED HOT Ring of desire of the Love Bucket.
Lifestyle is another ring of desire of the Love Bucket. Here we are talking about LOVER RELATIONSHIPS: Between two consenting adults who have deep love and affection for one another.
Living a happy life and a fulfilling lifestyle, reflects the attitudes and values of two lovers. A couple, lovers, or husband and wife often share a set of attitudes, habits, or possessions associated with a particular lifestyle. Sometimes arguments start when one person in a relationship feels the other is spending money beyond their lifestyle.
Keeping "The Love Bucket®" filled has a lot to do with relationship design, in particular, how you plan your lifestyle together. If you are not in a relationship, now is the time to determine what's important to you so you have the possiblity of creating your relationship x factor.
Get clarity on your relationship design plan. This will affect your lifestyle choices and your dating choices. If you are a man, I recommend checking out Dating Dynamics which is the dating black book for men. Attract women who you can win with. It doesn't matter if she is "out of your league" it matters that you can please and satisfy her and FILL HER LOVE BUCKET.
Back to lifestyle, when you share in life, ideally you share in your relationship design lifestyle. Within your relationship design is a common goal. It takes forethought and clear thinking to know your common goal. If you don't have a match on your common goal or it is so far off on the relationship design spectrum, the relationship will not last long.
If you don't plan your relationship design there will be rocky roads ahead. The common goal is the glue that holds things together in a relationship. Yes, it is true that some people have no plan and just accept a relationship by default. That is just subsistence living like accepting a steady meal of junk food when the choice of fine dining is available to you by simply planning.
Planning your lifestyle with your common goal in mind affects future activities. Just like you wouldn't be getting drunk every night if you had a goal of joining the Olympic Team, your day-to-day actions are influenced by your common goal.
The phases of relationship from dating, to accommodating, to established often happen without clear forethought or intention. Real Love Dynamics include the clear intention of a specific relationship design which can foster the possibility of experiencing true lovematism.
When you relate to your lover from the power position of being a "prorelator" the respect and love you share is expanded. When you identified and make the choice of your relationship design, your common goal becomes clearer to both lovers. A prorelator knows how to respond and listen to keep the common goal of a relationship moving forward in a positive, love and passion-filled direction. That's love's true north and real love dynamics working in harmony.
Sherrie Rose is known for her LOVE BUCKET concept and for the phrase: "He WINS + She's HAPPY =Your SEX LIFE is Enhanced." That's actually the Love Bucket® Formula.
The most passionate love relationships are filled with sexual dynamics and having clarity of purpose in your relationship design will boost sexual intimacy and stoke the smoldering fires of passion.
"It is not enough to be well-intentioned; one must strive to put those intentions into action in a capable way." ~Andrew Cohen
"Clear INTENTION in your relationship design is the key to safe navigation when the sea gets rocky in your love relationship."
~The Love Linguist
"Courage is rightly esteemed the first of human qualities, because it is the quality which guarantees all others."
~Winston Churchill
"It takes serious COURAGE to make a commitment to a love relationship."
~The Love Linguist
This webpage has been generated by love for your pleasure. Thank you for being here.
Some definitions for the words "relationship", "designs", "power", "plan" and more from: http://www.thefreedictionary.com
RELATIONSHIP definition as in relationship designs
1. The condition or fact of being related; connection or association.
2. Connection by blood or marriage; kinship.
3. A particular type of connection existing between people related to or having dealings with each other: has a close relationship with his siblings.
4. A romantic or sexual involvement
5. An emotional or sexual affair or liaison.
6. The mutual dealings, connections, or feelings that exist between two parties, countries, people, etc. a business relationship
DESIGNS definition as in relationship designs
v. de·signed, de·sign·ing, de·signs
a. To conceive or fashion in the mind; invent: design a good excuse for not attending the conference.
b. To formulate a plan for; devise: designed a marketing strategy for the new product.
2. To plan out in systematic, usually graphic form: design a building; design a computer program.
3. To create or contrive for a particular purpose or effect: a game designed to appeal to all ages.
4. To have as a goal or purpose; intend.
5. To create or execute in an artistic or highly skilled manner.
1. To make or execute plans.
2. To have a goal or purpose in mind.
3. To create designs.
LIFESTYLE definition as in relationship design lifestyle
life·style also life-style or life style
A way of life or style of living that reflects the attitudes and values of a person or group: "It was a millionaire's lifestyle on the pocketbook of a hairdresser" (People).
1. a set of attitudes, habits, or possessions associated with a particular person or group
2. such attitudes, etc., regarded as fashionable or desirable
PLAN definition as in relationship design plan
1. A scheme, program, or method worked out beforehand for the accomplishment of an objective: a plan of attack.
2. A proposed or tentative project or course of action
3. A systematic arrangement of elements or important parts; a configuration or outline: the plan of a story.
4. A drawing or diagram made to scale showing the structure or arrangement of something.
5. In perspective rendering, one of several imaginary planes perpendicular to the line of vision between the viewer and the object being depicted.
v. planned, plan·ning, plans
1. To formulate a scheme or program for the accomplishment, enactment, or attainment of: plan a campaign.
2. To have as a specific aim or purpose; intend: They plan to buy a house.
3. To draw or make a graphic representation of.
To make plans.
POWER definition as in relationship design power
1. The ability or capacity to perform or act effectively.
2. A specific capacity, faculty, or aptitude. Often used in the plural: her powers of concentration.
3. Strength or force exerted or capable of being exerted; might. See Synonyms at strength.
4. The ability or official capacity to exercise control; authority.
5. A person, group, or nation having great influence or control over others: the western powers.
6. The might of a nation, political organization, or similar group.
7. Forcefulness; effectiveness: a novel of unusual power.
MATE definition as in relationship design "culture mate"
1. One of a matched pair: the mate to this glove.
2. A spouse.
a. Either of a pair of animals or birds that associate in order to propagate.
b. Either of a pair of animals brought together for breeding.
a. A person with whom one is in close association; an associate.
b. Chiefly British A good friend or companion.
c. A person with whom one shares living quarters.
v. mat·ed, mat·ing, mates
1. To join closely; pair.
2. To unite in marriage.
3. To pair (animals) for breeding.
1. To become joined in marriage.
a. To be paired for reproducing; breed.
b. To copulate.
COMMON definition as in relationship common goal
a. Belonging equally to or shared equally by two or more; joint: common interests.
b. Of or relating to the community as a whole; public: for the common good. See Usage Note at mutual.
1. Having the same relationship each to the other: mutual predators.
2. Directed and received by each toward the other; reciprocal: mutual respect.
3. Possessed in common: mutual interests.
GOAL definition as in relationship common goal
1. The purpose toward which an endeavor is directed; an objective. See Synonyms at intention.
2. Sports
a. The finish line of a race.
b. A specified structure or zone into or over which players endeavor to advance a ball or puck.
c. The score awarded for such an act.
3. Linguistics
a. A noun or noun phrase referring to the place to which something moves.
INTENTION definition as in relationship design intention
1. A course of action that one intends to follow.
a. An aim that guides action; an objective.
b. intentions Purpose with respect to marriage: honorable intentions.
Synonyms: intention, intent, purpose, goal, end, aim, object, objective
These nouns refer to what one plans to do or achieve. Intention simply signifies a course of action that one proposes to follow: It is my intention to take a vacation next month.
Intent more strongly implies deliberateness: The executor complied with the testator's intent.
Purpose strengthens the idea of resolution or determination: "His purpose was to discover how long these guests intended to stay" (Joseph Conrad).
Goal may suggest an idealistic or long-term purpose: The college's goal was to raise ten million dollars for a new library.
End suggests a long-range goal: The candidate wanted to win and pursued every means to achieve that end.
Aim stresses the direction one's efforts take in pursuit of an end: The aim of most students is to graduate.
An object is an end that one tries to carry out: The object of chess is to capture your opponent's king.
Objective often implies that the end or goal can be reached: The report outlines the committee's objectives.
[Middle English entencioun, from Old French intention, from Latin intenti, intentin-, from intentus, intent, from past participle of intendere, to direct attention; see intend.]
SPECTRUM definition as in relationship design spectrum
n. pl. spec·tra (-tr) or spec·trums
1. Physics The distribution of a characteristic of a physical system or phenomenon, especially:
a. The distribution of energy emitted by a radiant source, as by an incandescent body, arranged in order of wavelengths.
b. The distribution of atomic or subatomic particles in a system, as in a magnetically resolved molecular beam, arranged in order of masses.
2. A graphic or photographic representation of such a distribution.
a. A range of values of a quantity or set of related quantities.
b. A broad sequence or range of related qualities, ideas, or activities: the whole spectrum of 20th-century thought.
Here are a few questions to ask yourself: Are you a student of love? What is the future of love? Do you know real love dynamics? What are the 5 Love Dynamics? Do you know how to fill the love bucket of your lover?
The Love Success Series™
A series of books and written articles in the field of self-improvement and relationships. Entertainment and education services, namely, providing live and on-line seminars, training, motivational speaking services and personal appearances by a spokesperson in the field of self-improvement and relationships. Important Notice - Please Read
The Love Bucket® Formula
© 2010 Everybody Loves Love® This website is Generated By Love www.GeneratedByLove.com.
Love Success Series, LLC, Henderson, NV, 89104 formerly The Love System. Love Success Series LLC, is the owner of registered trademarks:
The Love Bucket, 7 Rings of Desire, Sherrie Rose, The Love Linguist, Everybody Loves Love, and all related designs, copyrights, trademarks, and proprietary rights. This is legal, not love: All rights reserved. No part of this website may be reproduced in any form or by any means, electronic or mechanical, or by any information storage and retrieval system, without permission in writing from the author and publisher.• If you are in the membership community login in to your website for support or go to the lover help desk.


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Fontainebleau Miami Beach is a 5 luxury oceanfront hotel located in Florida USA in Miami beach 12 miles from Miami International Airport and 28 miles from Fort Lauderdale International Airport. The hotel offers a variety of amenities such as swimming pools bars restaurants gym spa massage water sports conference center and children facilities. Guests can relax in the spacious beautifully decorated rooms and suites of the hotel which are fully equipped and have wonderful view. Fontainebleau Miami Beach is the ideal place for relaxing and unforgettable vacations.
Hotel Facilities:
- Air Conditioning Climate Control
- Bar(s)
- Beauty Salon
- Childrens Playground
- Conference Banquet Meeting Facilities
- Golf Course
- Gym
- Massage
- Pool Bar
- Restaurant(s)
- Shops
- Sunbeds and or umbrellas
- Swimming Pool for Children
- Swimming Pool Outdoor
- Water Sports
- Wind Surf
Room Types Availabile:
Chateau Versailles Standard (A ):
- Air Conditioning
- Bathrobe
- Bathroom with bathtub or Shower
- Coffee Tea making facilities
- Hair Dryer
- LCD Sat TV
- Mini Bar
- Safety Box
- Telephone
- Terrace Balcony
- Wi Fi Internet Connection


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By Michael Marot, AP Sports Writer
INDIANAPOLIS Nicky Hayden's motorcycle career has taken him around the world. He's been to four continents, faraway places such as Qatar and Malaysia and has grown accustomed to the grueling travel schedule.
This week, he's getting a respite.
Instead of boarding planes or trains bound for some corner of the globe, the 27-year-old former world champion drove the 3 1/2 hours from Owensboro, Ky., to Indianapolis for Sunday's inaugural Red Bull MotoGP.
Welcome home, kid.
Known as The Kentucky Kid, Hayden started racing mini-bikes on dirt tracks before moving to road courses in 1992. Since then, he's mostly been on the road.
"To be racing so close to home, it just doesn't even seem real," Hayden said before practice began Friday. "Normally, I go to the airport, wait, fly to Chicago and then halfway around the world."
In some respects, the historic Indianapolis Motor Speedway is already a second home for Hayden.
He's done several exhibitions on the 2.6-mile road course this year and attended the Indianapolis 500 and Allstate 400 at the Brickyard to help promote the track's first motorcycle race in nearly a century.
But things haven't gone according to the script this week.
Hayden continues hobbling around on crutches while recovering from a right heel injury sustained during last month's X Games. His times during the first two practice sessions on the rain-soaked track weren't up to his usual standards, and he's hardly considered the favorite to win. Friday's steady rain didn't help matters. Hayden posted a fast lap of 82.777 mph, eighth on the day, and likely will have to contend with more rain Saturday and Sunday.
Plus, he's still trying to answer the one question that seems to nag all American racers: What's next?
Hayden plans to leave the Repsol Honda Team when the season ends Oct. 26 at Valencia because he's grown increasingly frustrated with what he considers the team's favorable treatment of teammate Dani Pedrosa of Spain. Pedrosa is currently third in the points standings, 77 points behind leader Valentino Rossi of Italy with 262. Hayden is 11th at 84 and has all but confirmed the long-rumored move to Ducati is true.
"It's no secret. Everybody knows where my next stop is going to be," he said. "But, officially, we're waiting to do it the right way. I'm looking forward to it. I know it's going to be a big change for me, and, hopefully, the announcement will be coming soon."
It could become official come this weekend.
Until then, Hayden is trying to focus on turning around his season.
He's managed just two podium appearances in 2008, finishing third at Italy and Germany. He missed the last two races because of the injury, never making onto the track in the Czech Republic and withdrawing at San Marino after qualifying 16th.
But Hayden, whose father also raced motorcycles, always intended to be back for Indy - perhaps the closest he'll come to a true homecoming in this series.
The good news is that the track should help Hayden. Because there are 10 left turns, compared with six right turns, he won't have to put as much pressure on the tender foot when shifting his weight and dropping the knee to turn. He hopes that's enough to keep him competitive Sunday.
"I'll be all right going left," he said. "It's certainly been another tough year for me, and probably the worst, honestly, if I'm honest, probably the worst season of my career so far. Things change quick in racing and there's no better time to turn it around than right here at home."
That would come in front of fans who have rarely seen him race. Two of his three career MotoGP wins have come in California.
And now Hayden, one of seven world champs from America, has a chance to put his name alongside Ray Harroun, Jeff Gordon and Michael Schumacher as winners of the speedway's inaugural races.
He's intent on making this weekend a successful homecoming.
"It's an awesome opportunity for me, and I think for MotoGP," he said. "There's a lot of people on the East Coast and California is a long way away. They can't afford to go to the West Coast, but they may be able to come here. Hopefully, we get some good weather and have a big weekend."
The Associated Press
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Imation 8 GB Atom USB Drive
Great little storage device! Comes with security software that allows you to create a password protected storage area. If you lose this USB drive, your data is secure. If someone else tries to hack into your data, they only have 5 chances to enter the correct password. After that, the drive reformats itself, preventing your data from falling into the wrong hands.
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Ronstadt, Katzenberg among those honored by Obama
Singer Linda Ronstadt, DreamWorks Animation chief Jeffrey Katzenberg and public radio host Diane Rehm are among those being honored at the White House for their contributions to arts and humanities.
President Barack Obama is awarding the 2013 National Medal of Arts and National Humanities Medal to 22 recipients in an East Room ceremony Monday. First lady Michelle Obama also plans to attend.
The National Medal of Arts was established by Congress in 1984 as the nation's highest award given to artists and their patrons. The National Humanities Medal was created in in 1997 to honor those who have deepened the nation's understanding of the humanities in fields including history, literature, languages and philosophy.
(Copyright 2014 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.)


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Does this sum up everybody else's day or is it just going on here?
LO: I like the old ones
me: You like the old ones?
LO: (sobbing/shrieking) NO! I like the NEW ones!!!
LO: I want milk
me: Ok (pouring milk into cup)
LO: (again sobbing and shrieking) NO! I don't LIKE milk!!!!
It goes like this all day.
I feel like she is chipping away at my brain. I swear I can feel little pieces flaking off into the ether. Is this a phase or just typical two year old stuff or have we entered early puberty? I'm joking, mostly, but can somebody give me some hope for my sanity?


text:
Charlie Sheen: the MMO.
k im just bored.
edit: pre-order CE now for ingame Tiger's Blood, Adonis DNA and Pornstar Pet.
sorry everyone, its either this or clean my apartment.
Edited, Mar 9th 2011 2:43pm by Llester
Edited, Mar 9th 2011 11:58am by Osarion Lock Thread: Clean your apartment lol


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Category Archives for "Articles"
I was part of a routine traffic stop a while back. My old, old car was missing its front license plate. After about an hour with the police officer, I was issued a ticket. He noted in conversation about four times that many owners of specialty or vintage cars didn't install their front plate because […]Continue reading
Long before the TV show Madmen, artist and oddball Salvador Dali noted that the difference between him and a madman, is that he's not a madman. Point taken. Every now and then though, you have to be armed for dinner parties with stories of mad people. One of the best to bring up is Swiss-born […]Continue reading
In the children's songs, Morningtown ride (1957 Malvina Reynolds), girls and boys under their blankets are "All bound for Morningtown/Many miles away." This refrain is repeated until near the end when we hear that "Somewhere there is Morningtown/Many miles away." I sang this song many times (badly) to my boys. The technique of indicating there's […]Continue reading
I judged a book by its cover recently—Beyond Rust seemed like it would be a good read. I'd learn more about Pittsburgh and the phenomenon known as the rust belt, and how some rusty areas came back. The Pittsburgh Renaissance was aided by the Alleghany Conference and public private partnerships. Through these efforts, thousands of […]Continue reading
My witty high school teacher used to ask questions in class. How many here want a particular lesson—raise your hands. How many here will be attending the event Friday afternoon—raise your hands, and so on. Then came the wit. "If anyone is not here, please raise your hand." Equally nutty is the use of devices […]Continue reading
When we think of cities that provide refuge for the wealthy, we tend to think of London, New York, Paris and perhaps Vancouver. Vancouver has just imposed a 15% tax on properties bought by foreign buyers. This might get challenged in court, might cool down the market, or might actually drive up prices with the […]Continue reading
If only thinking made it so. Someone in New Orleans wrote in that city's emergency plan that "disabled vehicles and debris will be removed from highways." Good idea. Won't happen. Kansas City, Missouri also notes "inoperative vehicles will be towed or pushed." Good idea. Won't happen. Brisbane, Australia's plan calls for students to help in […]Continue reading
There I sat with a very big potential client in a swanky boardroom in the USA. We exchanged pleasantries. The client wanted a "business continuity plan" sometimes referred to as a BCP, with the "C" sometimes standing for continuation. I pulled out my 3-ring binder—a 200 page template for a crisis management plan. I […]Continue reading
If you needed a hammer to fix a hammer, you'd be out of luck if you had a broken hammer. It's like the computer program that teaches you how to use computer programs. You have to know before you can know. It's this kind of irony I read in many urban emergency plans. Many cities […]Continue reading
"Freedom of the press is guaranteed only to those who own one" said legendary journalist A. J. Liebling. The writers of Halifax's urban emergency plan should have read this. They should also have noted Mark Twain's much older quote – "[n]ever pick a fight with people who buy ink by the barrel." You can update […]Continue reading


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Semantic inference using chemogenomics data for drug discovery
Semantic Web Technology (SWT) makes it possible to integrate and search the large volume of life science datasets in the public domain, as demonstrated by well-known linked data projects such as LODD, Bio2RDF, and Chem2Bio2RDF. Integration of these sets creates large networks of information. We have previously described a tool called WENDI for aggregating information pertaining to new chemical compounds, effectively creating evidence paths relating the compounds to genes, diseases and so on. In this paper we examine the utility of automatically inferring new compound-disease associations (and thus new links in the network) based on semantically marked-up versions of these evidence paths, rule-sets and inference engines.
Through the implementation of a semantic inference algorithm, rule set, Semantic Web methods (RDF, OWL and SPARQL) and new interfaces, we have created a new tool called Chemogenomic Explorer that uses networks of ontologically annotated RDF statements along with deductive reasoning tools to infer new associations between the query structure and genes and diseases from WENDI results. The tool then permits interactive clustering and filtering of these evidence paths.
We present a new aggregate approach to inferring links between chemical compounds and diseases using semantic inference. This approach allows multiple evidence paths between compounds and diseases to be identified using a rule-set and semantically annotated data, and for these evidence paths to be clustered to show overall evidence linking the compound to a disease. We believe this is a powerful approach, because it allows compound-disease relationships to be ranked by the amount of evidence supporting them.
Recent advances in chemical & biological sciences have led to an incredible increase in the volume of information about known chemical compounds, genes, diseases, and assays. Statistical data from the PubChem Substance Database of chemical structures, shows an increase from 35,379,748 structures in 2007 to 69,088,100 in 2010; the number of PubChem Bioassays increased from around 1000 in 2008 to 434,635 in 2010
We can imagine all these information resources as buckets for pieces of a very large jigsaw puzzle, each bucket containing only pieces of a certain color. To assemble the full picture we need to be able to search and apply algorithms that span across different buckets seamlessly. There are many technologies of utility for this, most recently from the Semantic Web Technology (SWT) community, like XML (for describing data), OWL (for describing ontologies and taxonomies), and RDF (for describing relationships) are allowing data aggregation and the representation of meaning and relationships in the data, and are now being quite widely applied for life science data. LODD
In our previous paper
Figure 1
WENDI Architecture
WENDI Architecture. WENDI main web interface is show at the upper right corner.
WENDI has good performance on data integration, but it relies on the user manually find associations among the kinds of results presented. At this point, we thus extended WENDI work to use semantic inference and rules to automatically infer new associations based on the WENDI XML results. These new associations in aggregate form clusters of association that build evidence of an association between compounds and diseases via multiple sources or evidence paths. We have implemented this in a tool called Chemogenomic Explorer that uses networks of ontologically-enabled RDF statements (e.g. the query compound C is similar to compound D, drug D is active in assay A, assay A is associated with gene G) along with deductive reasoning tools to infer relationships between the query compound and genes and diseases, this will allow us to cluster insights by disease, and then prioritize the output based on the amount of evidence linking a compound to a disease.
The WENDI web service is used to create an initial set of relational paths in XML. CE adds to the previously reported capabilities of WENDI through (i) the application and inference engine and rule set to enable new associations to be inferred; (ii) clustering and filtering of inferred evidence paths in a completely new interface and (iii) the application of Semantic Web languages and methods (RDF, SPARQL, OWL) to enable a much broader range of capabilities including creation and mining of evidence paths, and the annotation of relationships using the ontology. These new methods are described below.
WENDI XML includes the direct relationships between similar compounds and bioassays, similar compounds and literature references, bioassays and genes/diseases, and so on. The process of importing this information into CE is as follows: 1. Data preparation as described in section 2.1; 2. Semantic representation using a CE ontology and presentation in RDF format, described in section 2.2; 3. Rule-based Inference described in 2.3; and 4. Path ranking based on the number of properties for each disease described in 2.4.
Data preparation
WENDI aggregates information from diverse data sources and predictive models including PubChem Compound, PubChem Bioassay, PubChem3D
We extracted the above information from WENDI XML using XML DOM
Data representation
In order to provide a formal description of concepts, terms, and relationships within the WENDI knowledge domain and to make semantic inference possible, we use the Web Ontology Language (OWL) to build the CE ontology and the Resource Description Framework (RDF) in a variety of data interchange formats (e.g. RDF/XML, N3, Turtle, N-Triples) to present CE data based on the CE ontology.
CE OWL ontology is constrained for using in our system: i.e., it is an ontology specific to the datasets used in CE and is not a generalized chemogenomic ontology. Within the ontology we use the following entity classes: Chemical Compound, BioAssay, Journal Article, Gene, and Disease. These entities can be associated by relational ontological terms as shown in Table
Table 1
Examples of Object Properties and Classes for the CE Ontology
Chemical Compound,
Chemical Compound
Chemical Compound is similar to Chemical Compound
Chemical Compound,
PubChem BioAssay
Chemical is tested active in the bioassay
Chemical Compound,
Journal Article
Chemical is contained in the article
Pubchem BioAssay/Drug/Journal Article, Gene
Bioassay/Drug/Article has found the gene term related the corresponding text;
Bioassay/Drug/Article has a reference to the gene
Pubchem BioAssay/Drug/Journal Article, Disease
Bioassay/Drug/Article has found the disease term related the corresponding text;
Bioassay/Drug/Article has a reference to the disease
Gene, Disease
Gene and disease is associated
Chemical Compound, Similarity
Chemical has similarity value based on Tanimoto coefficient.
Table 2
CE triple examples based on CE Ontology
CE Triple Examples
WO:querycmpd WO:isSimilarTo WO:cid24871487.
WO:cid24871487 rdf:type WO:ChemicalCompound;
WO:isActiveIn WO:aid1469.
WO:aid1469 rdf:type WO:BioAssay;
WO:hasGenes WO:COL4A4.
WO:COL4A4 rdf:type WO:Gene;
WO:isAssociatedWith WO:Nephritis.
Figure 2
RDF Network for CE
RDF Network for CE.
Inference and the Rule Base
Once the CE RDF triples are generated, they are loaded into Ont Model Class
[Rule 1: (?QueryCompound WO:isSimiliarTo ?CompoundID),
(?CompoundID WO:isActiveIn ?Bioassay),
(?Bioassay WO:isAssociatedWith ?Disease)
-> (?QueryCompound WO:mightHasDisease ?Disease)]
Explanation: A relationship is inferred between a compound and a disease if the query compound is similar to another compound that is active against a PubChem Bioassay, and that Bioassay is associated with a disease.
[Rule 2: (?CompoundID WO:isContainedIn ?Journal),
(?Journal WO:hasGene ?Gene),
(?Gene WO:isAssociatedWith ?Disease)
-> (?CompoundID WO:mightHasDisease ?Disease)]
Explanation: A new compound-disease relationship is inferred if there a similar compound and a gene co-occur in a paper abstract, and the gene and disease co-occur in another paper abstract.
[Rule 3: (?CompoundID WO:isActiveIn ?Bioassay),
(?Bioassay WO:hasGene ?Gene),
(?Gene WO:isAssociatedWith ?Disease)
-> (?CompoundID WO:mightHasDisease ?Disease)]
Explanation: A new compound-disease relationship is inferred if a similar compound is active against a bioassay, the bioassay is associated with a gene, and the gene co-occurs in a paper abstract with the disease.
We selected Methysergide
Table 3
CE RDF statement examples
RDF Statements
wo:ctdcid9681 rdf:type wo:ChemicalCompound.
wo:querycmpd wo:isSimilarTo wo:ctdcid9681;
wo:hasSimilarity "1.000".
wo:ctdcid9681 wo:hasName "Methysergide".
wo:HTR1B rdf:type wo:Gene;
wo:isrelatedTo wo:cid9681;
wo:isInferredFrom "pubmedid8743744".
wo:Autistic_Disorder rdf:type wo:Disease;
wo:isAssociatedWith wo:HTR1B;
wo:isInferredFrom "pubmedid19038234".
A Methysergide-Autistic Disorder relationship is inferred via rule 2 (gene HTR1B). The similar compound (cid = 9681) is Methysergide itself with similarity = 1, it co-occurs with gene HTR1B in a same paper (pubmed id = 8743744), and HTR1B and Autistic_Disorder are co-occurring in another same paper (pubmed id = 19038234). Then we use rule 2 to establish such relations;
wo:ctdcid11865408 rdf:type wo:ChemicalCompound.
wo:querycmpd wo:isSimilarTo wo:ctdcid11865408;
wo:hasSimilarity "0.774".
wo:ctdcid11865408 wo:hasName "Metergoline".
wo:HTR1B rdf:type wo:Gene;
wo:isrelatedTo wo:cid11865408;
wo:isInferredFrom "pubmedid1330643".
wo:Autistic_Disorder rdf:type wo:Disease;
wo:isAssociatedWith wo:HTR1B;
wo:isInferredFrom "pubmedid19038234".
A Methysergide-Autistic Disorder relationship is also inferred via rule 2 (again via HTR1B). Although this is the same relationship, a different evidence path considered (we will do path ranking on these evidence paths later);
wo:cid5486180 rdf:type wo:ChemicalCompound.
wo:querycmpd wo:isSimilarTo wo:cid5486180;
wo:hasSimilarity "0.929".
wo:cid5486180 wo:isActiveIn wo:aid410.
wo:aid410 rdf:type wo:BioAssay;
wo:hasName "p450-cyp1a2".
wo:CYP1A2 rdf:type wo:Gene.
wo:aid410 wo:hasGene wo:CYP1A2.
wo:CYP1A2 wo:isAssociatedWith wo:Lymphoma.
wo:Lymphoma rdf:type wo:Disease.
A Methysergide-Lymphoma relationship is inferred by rule1 (via CYP1A2).
Methysergide as the query compound, we got a total of 63 evidence paths with different diseases, genes, and journal information. Individual evidence paths can be examined to get to the root data or publications that constitute them. For instance, the Autism link is demonstrated is interesting as the publications identify the link of the compound with HTR1B and the link of HTR1B with Autism. LSD is known to affect the outcome of Autism
Browsing RDF is clearly difficult, we have thus built an interface that allows the results to be examined and filtered in a user-friendly fashion, more details about the interface shows in the next section. Specifically, evidence paths are clustered by disease, and can be filtered via disease, compounds, assays, genes, gene families, or journal titles. Part of the results for Methysergide are shown in Figure
Figure 3
Results related to "Autistic_Disorder" for Methysergide shown in the CE Faced Browser by using Disease filter
Results related to "Autistic_Disorder" for Methysergide shown in the CE Faced Browser by using Disease filter.
Figure 4
Results related to AID "410" for Methysergide shown in the CE Faced Browser by using AID filter
Results related to AID "410" for Methysergide shown in the CE Faced Browser by using AID filter.
Path Ranking
The above process results are often in many evidence paths linking compounds and diseases. With a large number of results, we need some way to organize and prioritize these evidence paths. We cluster all the paths based on the different disease terms and then rank the clusters based on the number of evidence paths linking them. Whilst evidence paths are not necessarily fully independent, they do constitute different collections of evidence for the same relationship, and thus strengthen the chances of the relationship being significant.
We employ the following SPARQL query clause to implement this ranking process based on the inferred RDF. It counts the number of properties (?pc) related to each disease first, and then return disease terms (?dis) as descend order on the basis of (?pc).
Select ?dis (count(?p) as ?pc)
WHERE {?dis a wo:Disease; ?p ?o}
GROUP BY ?dis ORDER BY DESC(?pc)
Results and discussion
The architecture for CE is shown in Figure
Figure 5
CE Architecture and Path Ranking Flowchart
CE Architecture and Path Ranking Flowchart.
Faceted Browser for CE
CE provides a main web interface, shown in Figure
Figure 6
CE main Web Interface
CE main Web Interface.
SPARQL Query Builder for CE
After XML to RDF conversion, CE has RDF triples based on CE ontology. We therefore saw the utility of allowing the direct querying of this RDF data. Since SPARQL is a complex language, we implemented a SPARQL Query Builder to semi-automate this process. The SPARQL query builder for CE is built based on the Sesame triple store
Figure 7
Main Web Interface of CE SPARQL Query Builder
Main Web Interface of CE SPARQL Query Builder.
As an example, given the relationship of Methysergide
1) Find similar compounds to Methysergide from the literatures,
Subject: wo:ChemicalCompound
Predict: wo:isContainedIn
Object: wo:journalArticle
2) The titles of the papers should include "5-HT",
Subject: wo: journalArticle
Predict: wo:hasTitle
Object: "5-HT"
The implementation of this query is shown in Figure
Table 4
List of Journal Titles including "5-HT" receptor
Journal Titles
First Pharmacophoric Hypothesis for 5-HT7 Antagonism
Novel, Potent, and Selective 5-HT3 Receptor Antagonists Based on the Arylpiperazine Skeleton: Synthesis, Structure, Biological Activity, and Comparative Molecular Field Analysis Studies
Synthesis of 2-Piperazinylbenzothiazole and 2-Piperazinylbenzoxazole Derivatives with 5-HT3 Antagonist and 5-HT4 Agonist Properties
Novel and Highly Potent 5-HT3 Receptor Agonists Based on a Pyrroloquinoxaline Structure
Identification of potential gene targets and diseases for Clozapine
In order to validate CE, we tested it with well-known drugs as queries, to see how the ordering of the clusters of evidence paths related to known uses and side-effects for these drugs. For example Clozapine
Figure 8
CE results for Clozapine
CE results for Clozapine.
Exploring newly submitted compounds from PubChem
Pubchem is a popular public database of chemical compounds and their activities against biological assays. Since CE is designed for use with "new" compounds as queries (i.e. compounds for which there is not a lot of data available), we chose a set of very recently-added compounds in PubChem which had no or little associated bioactivity information recorded. This was done using a constrained search in PubChem
For example, as shown in Figure
Figure 9
More Chemogenomic information for New Compound from PubChem
More Chemogenomic information for New Compound from PubChem.
We were using RDF network to make inference between compounds and diseases. As the experiments discussed before, not only the most related diseases could be sorted out, but also general guideline will be generated to conduct new compounds analysis. The power of the methodology has been clearly demonstrated to retrieve pertinent information in particular domain without any difficulties engendering by the data tsunami. In addition, it expands the possible usages/linkages within the limited volumes of disease information regarding to a specific compound.
We present a new approach to the association search of chemical compounds and diseases using semantic inference in this work. Semantic inference produces evidence paths relating compounds and diseases via genes, publication, bioassays and drugs. We previously released an aggregative data-mining tool, WENDI, for drug discovery using aggregate web services. In this paper, we have shown how the application of Semantic Web methods (RDF, SPARQL and OWL ontologies) along with rule-based inference, path ranking and a faceted browse, can produce a tool for exploring new compound-disease associations based on evidence paths from WENDI.
Future work
The current version of CE explores the chemogenomic information of chemical compounds. In the future, we will consider more efficient ways to mine compound-gene, compound-disease links from more chemogenomic data, and plan to aggregate additional data and inference rules, also increase collaboration with Chem2Bio2RDF in order to enable CE to link with more diverse data. We also intend to expand beyond Chem2Bio2RDF to chemical biology, where we can consider other relations like chemical-gene, chemical-pathway, chemical-side effect, etc. In addition, we would like to add the functionality to process batches of molecules. For this case, we will consider the issues of information summarization and visualization, i.e. how to organize more data in a readable way. Because of the increased volume of data and results, some current algorithms will become out of date. We will also take other ranking algorithms into account such as evidence importance.
Competing interests
The authors declare that they have no competing interests.
Authors' contributions
ZQ carried out the majority of the implementation of Chemogenoic Explorer. SYY and ZQ worked on the exploring tools. ZQ and SC worked on the semantic inference. DJW and DY assembled this paper from a previous white paper written by ZQ. All contributed to the intellectual evolution of this project. All authors have read and approved the final manuscript.
This project is supported by Eli Lilly and Company. We thank Bret Davidson for correcting English. We would like to thank the anonymous reviewers for their helpful comments and suggestions.
Chem2Bio2RDF: A semantic framework for linking and mining chemogenomic and systems chemical biology data
flexible semantic inference methodology to reason about user preferences in knowledge-based recommender systems
Semantic Inference in the Human-Machine Communication
Life sciences on the semantic web: the Neurocommons and beyond
SciNetS Search: Inference Search over an Integrated Life-sciences Database Based on the Semantic Web
GORouter: an RDF model for providing semantic query and inference services for Gene Ontology and its associations
WENDI: A tool for finding non-obvious relationships between compounds and biological properties, genes, diseases and scholarly publications
PubChem3D is a 3D version of PubChem, in which we have generated a single conformer for 99% of PubChem using the smi23d suite of programs
HuGE Navigator
Phenopred Matrix
Gene Ontology
Semantic Inference
The Semantic Web: An Introduction
Chemogenmic Explorer Rules
Treatment of autistic schizophrenic children with LSD-25 and UML-491
The variable effects of LSD-25 on the behavior of a heterogeneous group of childhood schizophrenics
Clozapine may be more effective than olanzapine for reducing suicidal behaviour in people with schizophrenia at high risk
Masked clozapine-induced cardiomyopathy
Myocarditis and cardiomyopathy associated with clozapine
PubChem advanced search
PubChem CID = 49835692


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Note: Selecting "No" will opt you out of receiving leads for Kids' Birthday Parties. You can always update your settings for this and other event types in the Profile tab by editing Event Type Selections.
Comprised of a variety of instruments not typical in western countries, Middle Eastern bands offer something different for your next event. The distinctive, exotic sound of a Middle East band is tantalizing and intriguing, always a welcome change from the ordinary.


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Motion Picture Visual Effects
We create Visual Effects for Film, T.V and Games. We also create cinematic promo videos, titles and end credits, trailer / promotional and or music videos for many Movie & T.V studios
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We create Movie Poster & DVD/Blu-Ray Cover artwork. We also design book covers and promotional graphics / videos & artwork for various well known authors and publishers.
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We can provide technical support for all of your I.T. needs. We can also create custom and interactive training for online, mobile and offline teaching.
We have created work for Visual Effects and Design houses in 17 different countries
Over 2000 Film and T.V projects and counting. This year we are moving into Books
We have over 100 clients and it's growing with every year that we create content
Years+ Experience
We have created VFX and Printed Design for over 20 years. We look forward to the next 20