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Genomic variation in the vomeronasal receptor gene repertoires of inbred mice
Human and rodent genomics
Vomeronasal receptors (VRs), expressed in sensory neurons of the vomeronasal organ, are thought to bind pheromones and mediate innate behaviours. The mouse reference genome has over 360 functional VRs arranged in highly homologous clusters, but the vast majority are of unknown function. Differences in these receptors within and between closely related species of mice are likely to underpin a range of behavioural responses. To investigate these differences, we interrogated the VR gene repertoire from 17 inbred strains of mice using massively parallel sequencing.
Approximately half of the 6222 VR genes that we investigated could be successfully resolved, and those that were unambiguously mapped resulted in an extremely accurate dataset. Collectively VRs have over twice the coding sequence variation of the genome average; but we identify striking non-random distribution of these variants within and between genes, clusters, clades and functional classes of VRs. We show that functional VR gene repertoires differ considerably between different
Together our results suggest that the unusually variable VR repertoires of mice have a significant role in encoding differences in olfactory-mediated responses and behaviours. Our dataset has expanded over nine fold the known number of mouse VR alleles, and will enable mechanistic analyses into the genetics of innate behavioural differences in mice.
The clone-based sequencing and assembly of the first high quality mouse genome, from the inbred C57BL/6J strain, revealed over 20,000 protein coding genes
The rodent VR repertoire consists of three distantly related families of G-protein coupled receptor, each expressed in sensory neurons of the vomeronasal organ in the nose: V1Rs, V2Rs and Formyl-peptide receptors (FPRs)
The number of VRs identified in the C57BL/6J genome steadily increased with each draft genome assembly release, but has stabilised as the genome nears completion
Although the variation in VR repertoire between divergent species is well documented
Our understanding of intra-specific VR variation is even more limited. On one hand VRs may be expected to be under stabilising selection within a species, favouring low variation in receptor characteristics to ensure essential chemo signals (predator cues or sex-specific signals, for example
The development of massively parallel sequencing (MPS) now offers the opportunity to rapidly and affordably resequence genomes from multiple individuals of the same species
Here we interrogate the full complement of coding VR gene sequences in these 17 strains, compared to the C57BL/6J reference. We show that MPS can accurately resolve over half of mouse VRs, but that copy number variation (CNV) and non-specific short read mapping confounds complete repertoire analysis. We identify divergent patterns in the number and distribution of single-nucleotide polymorphisms (SNPs) within genes, clades and clusters of VRs, as well as between strains, and present evidence that the functional vomeronasal repertoire may vary significantly between
Generating an accurate dataset of VR SNP variation
We collected SNP data in the open reading frames of 366 genes across 17 strains (a total of 6222 genes and over 9 Mb of DNA sequence), each encoding a potentially functional VR identified in the C57BL/6J reference genome. We then adopted a conservative parsing strategy to ensure accurate and statistically robust data, removing genes on the basis of ambiguous read calls, read mapping quality and incomplete gene coverage (see Materials and Methods and Additional file
Additional file 1
Table S1. Listing the numbers of VRs at each stage of our parsing process, subdivided by receptor class.
Click here for file
Additional file 2
Table S2. Listing the SNP distribution in VR repertoires, subdivided by receptor class.
Click here for file
To assess the accuracy of our dataset, we compared VR sequences identified by MPS with those generated by traditional long-read, capillary sequencing. Recently Kurzweil
VR SNP distribution among mouse strains
The 17 sequenced strains were carefully selected to ensure maximum utility among the research community, and include 14 common lab strains, as well as strains more recently derived from wild-caught mice of other
Figure 1
The distribution of SNPs within VRs between inbred strains of mice
The distribution of SNPs within VRs between inbred strains of mice. (A) The distribution of the total number of SNPs identified within the coding region of vomeronasal receptor genes (VRs) compared with the total number of SNPs in the entire accessible genomes. (B) A similar comparison showing the relative distribution of private SNPs (those that are unique to one strain). The distributions of SNPs across entire accessible genomes were calculated from data in
Functional variation in VRs
SNPs within the coding region of genes can be divided into two classes based on functional consequence: those that are predicted to alter the resultant amino acid sequence (non-synonymous substitutions) and those that do not influence the sequence of the protein product (synonymous mutations). We identified 6394 non-synonymous SNPs, 57% of the total, and found no difference in the ratio of non-synonymous to synonymous SNPs between wild-derived and lab strains (Figure
Figure 2
Evidence of dynamic selective pressures on VR repertoires in both laboratory- and wild-derived strains
Evidence of dynamic selective pressures on VR repertoires in both laboratory- and wild-derived strains. (A) The ratio of non-synonymous to synonymous SNPs in VRs is similar between wild- and lab-derived strains (mean + SEM. Two-tailed t-test, P = 0.622), but higher than the genome averages (dashed lines: lab-derived = 0.54, wild-derived = 0.49 calculated from the data in
V1Rs and FPRs are members of the class A rhodopsin-like receptor superfamily
To further assess the functional constraint on VRs, we next determined how many non-synonymous SNPs created a termination codon that results in a premature truncation of the reading frame, potentially rendering the mature receptor non-functional. We identified 76 new termination codons that collectively truncate 70 VR genes (Figure
Additional file 3
Figure S1. Showing an example of a VR,
Click here for file
Additional file 4
Figure S2. Showing evidence of a duplication in
Click here for file
Figure 3
A heat map of functional variation by vomeronasal receptor class and phylogeny
A heat map of functional variation by vomeronasal receptor class and phylogeny. The amount of functional variation in all genes in our parsed dataset is represented by colour (black to yellow). The values are normalised between and within strain, as the number of non-synonymous SNPs in a kilobase of coding sequence. Each row represents a gene from the (A) V1R (B) V2R and (C) FPR sub-families, arranged by phylogeny (left). Where receptor sub-families have been further divided into recognised phylogenetic clades, those are indicated (right) in alternating shade of grey. The clade nomenclature is as described
SNP distribution between and within VR families
Cellular expression of the three known sub-families of vomeronasal receptors, V1R, V2R and FPRs is segregated within the VNO, but it is not yet known whether the behaviours they regulate are functionally distinct and therefore under different selective pressures. We therefore analysed the sequences of each sub-family independently to assess for differences in genomic variation, and considered only those SNPs with the potential to have a functional consequence. After normalisation for gene length, we find the mean abundance of non-synonymous SNPs across all strains to be very similar between V1Rs and V2Rs in both lab-derived strains (0.635/kb and 0.681/kb) and wild-derived strains (3.516/kb and 3.429/kb). The small family of FPRs have increased mean abundances in lab strains, but the increase is not significant and largely the consequence of one unusually variable outlier,
Figure 4
Correlations between receptor coding variation, clade, chromosomal location and function
Correlations between receptor coding variation, clade, chromosomal location and function. (A) The accumulation of non-synonymous SNPs does not differ between VR sub-families within either lab-derived or wild-derived strains (Mean + SEM. Two-way ANOVA, variance in receptor subfamily F2,28 = 0.312, P = 0.734, variance in strain F1,28 = 17.01, P = 0.001. Bonferroni
As we found no evidence of differences between entire VR sub-families we next tested whether there was statistical correlation in variation within sub-families, based on the hypothesis that closely related receptors are likely to be activated by closely related ligands that may, in turn, regulate similar types of behaviours. Considering wild-derived and lab-derived strains independently, principal component analyses (PCA, an unsupervised linear feature extraction method that discovers the directions of maximal variances in data) found highly significant correlations between non-synonymous SNP distribution and phylogeny within lab strain V2Rs (Two-way ANOVA, variance by V2R clade F12,858 = 17.99, P < 0.0001). For example, over 90% of the V2R variation in lab-derived strains can be represented by four principal components (eigenvalues <2). Grouping of VRs by cluster is apparent by the first two components in PCA, as shown by V2RB and V2RC, which are highly conserved among lab-derived strains, and V2RA5, which is highly variable (Figure
SNP distribution between functional classes of V2R
Recently Isogai
Massively parallel sequencing of VRs
To our knowledge, this is the first application of MPS to specifically resequence and analyse vomeronasal receptor genes. Therefore we first assessed whether current technology was capable of accurately resolving the sequences of these highly homologous, clustered sequences. Across entire genomes, 77-87% of reference sequence can be resolved, depending on the strain
Considerations in using inbred strains for behavioural research
Domestication by hundreds of generations of inbreeding has resulted in strains of laboratory mouse that display constrained innate behavioural responses when compared to wild (or recently wild-derived) relatives
Selection on VRs in inbred mice
We found that the distribution of SNPs in lab-derived strains is not random, but correlated with VR clade and genomic clusters, suggesting at least some VRs remain under selective constraint during the process of domestication by humans. It is tempting to speculate that those clades with the least variation mediate critical pheromone-mediated behaviours, such as reproduction or maternal care, which are essential even in a laboratory environment. However the paucity of VRs with defined ligands or functions makes it impossible to draw firm conclusions at this time. Of the VRs with known ligands
As a corollary to selection for essential VRs, receptors that are widely inactivated may be either disadvantageous (or inconsequential) to domesticated environments. Recently a study demonstrated examples of acquired pheromone resistance during domestication of
VRs between species and subspecies of mice
We used four wild-derived strains as representatives of "wild" species and subspecies of
Here we have resolved, analysed and compared the full coding sequences of over 3300 pheromone receptors of unknown function, from 17 strains of inbred mice using massively parallel sequencing data of whole genomes. We describe complex patterns of non-random sequence variation that indicate these receptors are under divergent selective pressures that correlate with proposed ligand, phylogeny, chromosomal clustering, and protein domain. Moreover, we demonstrate that VR protein sequences are unusually variable between mice, and that the repertoire of functional genes differs significantly, mirroring the inter-individual diversity in pheromone ligands. Together this supports a two-component model in which differences in both receptor and pheromone ligand sequence (and expression) may together genetically encode a diverse range of innate responses. We anticipate, as VRs are increasingly deorphanised in mice, the data described here will be invaluable for investigation into the genetic basis of behavioural differences.
Data collection
We retrieved VR cDNA sequences from 239 V1R
Additional file 5
Lists all the SNPs identified in V1Rs, subdivided by gene and strain.
Click here for file
Additional file 6
Lists all the SNPs identified in V2Rs, subdivided by gene and strain.
Click here for file
Additional file 7
Lists all the SNPs identified in FPRs, subdivided by gene and strain.
Click here for file
SNP density heat maps were generated using Cluster and Java Treeview
VR domains
TMHMM was used to predict the location of the beginning of the first trans-membrane domain in each V2R
Comparisons with published sequence data
We aligned the V1R sequences reported by Kurzweil
Total counts of synonymous and non-synonymous SNPs across the entire 17 genomes are from the data described in
V2R functional categorisation
V2Rs that respond to conspecific, predator or sympatric cues were identified from
Statistical analysis
Two-way ANOVA with repeated measures for strain followed by Bonferroni
CNV: Copy number variation; FPR: Formyl-peptide receptor family; MPS: Massively parallel sequencing; PCA: Principal component analysis; SNP: Single nucleotide polymorphism; V1R: Vomeronasal receptor family 1; V2R: Vomeronasal receptor family 2; VNO: Vomeronasal organ; VR: Vomeronasal receptor; VSN: Vomeronasal sensory neuron.
Competing interests
The authors declare that they have no competing interests.
Authors' contributions
DL conceived the project. EW, KC and DL collected and analysed the V2R data, EW and DL collected and analysed the V1R and FPR data. GSA devised and carried out the principal component and statistical analyses. DL and GSA produced the figures and DL drafted the manuscript. All authors read and approved the final manuscript for publication.
We are grateful to David Adams, Thomas Keane and Leo Goodstadt of the Mouse Genomes Project for sharing pre-publication sequence data and unpublished analysis of the 17 genomes, Carl Anderson for providing statistical advice, Ian Jackson for advice on mouse strains, Maria Levitin for technical support, and Rachel Larder and Ximena Ibarra-Soria for helpful discussion. This work was supported by the Wellcome Trust, grant number 098051. DWL is a Wellcome Trust Career Development Fellow and KJC is the recipient of a Wellcome Trust PhD studentship.
Lineage-specific biology revealed by a finished genome assembly of the mouse
Initial sequencing and comparative analysis of the mouse genome
From pheromones to behavior
Species specificity in major urinary proteins by parallel evolution
Sex- and strain-specific expression and vomeronasal activity of mouse ESP family peptides
The mechanism of expansion and the volatility it created in three pheromone gene clusters in the mouse (Mus musculus) genome
Species specificity in rodent pheromone receptor repertoires
Adaptive diversification of vomeronasal receptor 1 genes in rodents
Composition and evolution of the V2r vomeronasal receptor gene repertoire in mice and rats
Extreme variability among mammalian V1R gene families
V2R gene families degenerated in primates, dog and cow, but expanded in opossum
Molecular and evolutionary analyses of formyl peptide receptors suggest the absence of VNO-specific FPRs in primates
Identification of protein pheromones that promote aggressive behaviour
The male mouse pheromone ESP1 enhances female sexual receptive behaviour through a specific vomeronasal receptor
A novel family of genes encoding putative pheromone receptors in mammals
A novel family of putative pheromone receptors in mammals with a topographically organized and sexually dimorphic distribution
A multigene family encoding a diverse array of putative pheromone receptors in mammals
A new multigene family of putative pheromone receptors
Formyl peptide receptors are candidate chemosensory receptors in the vomeronasal organ
Formyl peptide receptor-like proteins are a novel family of vomeronasal chemosensors
Co-expression of putative pheromone receptors in the sensory neurons of the vomeronasal organ
Combinatorial co-expression of pheromone receptors, V2Rs
A recent class of chemosensory neurons developed in mouse and rat
Structural requirements for the activation of vomeronasal sensory neurons by MHC peptides
Pheromone detection mediated by a V1r vomeronasal receptor
Deficient pheromone responses in mice lacking a cluster of vomeronasal receptor genes
Ultrasensitive pheromone detection by mammalian vomeronasal neurons
MHC class I peptides as chemosensory signals in the vomeronasal organ
Sex-specific peptides from exocrine glands stimulate mouse vomeronasal sensory neurons
In vivo vomeronasal stimulation reveals sensory encoding of non specific and allospecific cues by the mouse accessory olfactory bulb
The vomeronasal organ mediates interspecies defensive behaviors through detection of protein pheromone homologs
Molecular organization of vomeronasal chemoreception
Dynamic evolution of V1R putative pheromone receptors between Mus musculus and Mus spretus
The microevolution of V1r vomeronasal receptor genes in mice
Individual recognition in mice mediated by major urinary proteins
Significant gene content variation characterizes the genomes of inbred mouse strains
Mouse segmental duplication and copy number variation
Limited variation in the major urinary proteins of laboratory mice
Parallel evolution of domesticated Caenorhabditis species targets pheromone receptor genes
The mouse genetics toolkit: revealing function and mechanism
Mouse genomic variation and its effect on phenotypes and gene regulation
Sequence-based characterization of structural variation in the mouse genome
Wild mice: an ever-increasing contribution to a popular mammalian model
Subspecific origin and haplotype diversity in the laboratory mouse
On the subspecific origin of the laboratory mouse
Independent hhsearch, needleman-wunsch-based, and motif analyses reveal the overall hierarchy for most of the g protein-coupled receptor families
Large-scale analysis of gene structure in rhodopsin-like GPCRs: evidence for widespread loss of an ancient intron
The complexity of their activation mechanism opens new possibilities for the modulation of mGlu and GABAB class C G protein-coupled receptors
How to map billions of short reads onto genomes
Assembly of large genomes using second-generation sequencing
A new twist on behavioral genetics by incorporating wild-derived mouse strains
Neuronal and behavioral differences between Mus musculus domesticus (C57BL/6JBy) and Mus musculus castaneus (CAST/Ei)
Mouse defensive behaviors: pharmacological and behavioral assays for anxiety and panic
The genetic basis of inbreeding avoidance in house mice
Maternal influences on adult stress and anxiety-like behavior in C57BL/6J and BALB/cJ mice: a cross-fostering study
Performances of inbred and outbred laboratory mice in putative tests of aggression
Darcin: a male pheromone that stimulates female memory and sexual attraction to an individual male's odour
Analysis of male pheromones that accelerate female reproductive organ development
Coordinated coexpression of two vomeronasal receptor V2R genes per neuron in the mouse
Reinforcement selection acting on the European house mouse hybrid zone
A candidate subspecies discrimination system involving a vomeronasal receptor gene with different alleles fixed in M. m. domesticus and M. m. musculus
Dindel: accurate indel calls from short-read data
LookSeq: a browser-based viewer for deep sequencing data
Java Treeview–extensible visualization of microarray data
Open source clustering software
MEGA: a biologist-centric software for evolutionary analysis of DNA and protein sequences
Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes
Clustal W and Clustal X version 2.0


text: Valentino to Launch Watches Valentino in deal with Timex Group. By Caroline Tell on September 3, 2008 The Valentino brand is launching watches in partnership with Timex Group. The collection, titled Valentino Timeless, bowed quietly in April at the Baselworld watch and jewelry fair and will hit high-end boutiques and specialty stores this fall. The Timeless collection will also retail at Valentino boutiques worldwide. Retail prices will range from about $1,000 to $15,000. WWD logo To Read the Full Article SUBSCRIBE NOW Already a Subscriber? Log in. Tap into our Global Network Of Industry Leaders and Designers load comments blog comments powered by Disqus

subset: commoncrawl


text: The name Deer Me Upholstery most definitely speaks for itself…particulary when combined with these beautiful images. This small Australian label is powered by Tracey Simmonds who took inspiration from her daughter's Year 12 art folio focusing on antlers and simply ran with it! With her daughter's creative input she now screen prints and produces a range of soft furnishings on plush natural fabrics which she supplies to stores and stocks herself online.


text:
Unfortunately, our phones are down right now. (Verizon is doing some work in the area.)
However, you can certainly place your order in the shop or online at www.russanddaughters.com.
And, of course, you can email us with orders/questions! info(AT)russanddaughters.com.
Thank you for understanding. We'll update here and on Twitter when the phones are back up and running.


text:
Murder accused told gardai he 'didn't finish off' neighbour whose body was found in a wardrobe
A man accused of murdering a neighbour whose body was found in a wardrobe days after his death denied he "finished off" the deceased, a court has heard.
Anthony Locke (38) told gardai in interview that he did not stab Christopher Jackson or have any weapon.
When asked if he had "finished off" the deceased man, he replied that he had not.
Mr Locke, of Ramillies Road in Ballyfermot, has pleaded not guilty to the murder of Christopher Jackson at his apartment on Prussia Street, between September 6th and 7th, 2012.
Detective Garda Kevin Moran said Mr Locke told him that his fingerprints would probably be on the knife as his brother, Bernard, could have put it in his hand as he slept.
Det Gda Moran told Mr Conor Devally SC, prosecuting, that the accused said his brother would have killed him too if he'd tried to stop him stabbing Mr Jackson.
He said the accused denied he had cut his finger stabbing Mr Jackson and added that his brother had inflicted the injury.
Detective Sergeant Denis Ellard told Mr Devally that the accused denied "interfering" or looking at the deceased's penis.
In his final garda interview, Mr Locke told gardai: "For the record, I had nothing to do with the death".
Det Sgt Ellard agreed with Mr Padraig Dwyer SC, defending, that that Mr Locke hadn't exercised his right to remain silent and had given details that would have implicated him in an offence of concealing a body.
The detective sergeant agreed that the accused had described a black handled knife which fitted with the investigation and that the deceased man's partner, Barbara Staunton, had not identified such an implement.
He said he didn't deal with forensic analysis when Mr Dywer asked him why his client's clothes had not been technically examined.
He said he was aware Mr Locke had presented himself at a garda station when Mr Dwyer put it to him that gardai had arrested Bernard Locke near the scene and had to find Ms Staunton for interview.
The trial has reached closing stages before Mr Justice Patrick McCarthy and a jury of six men and six women.


text:
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text:
JACKSON, (AP) - Today marks the opening of elk hunts in Grand Teton National Park and the National Elk Refuge in northwest Wyoming. Grand Teton is mandated by federal law to conduct an elk reduction program, when necessary, for the conservation of the elk population in Jackson Hole.
Wyoming-licensed hunters can get permits to hunt in certain areas of the park. A park permit temporarily deputizes the hunters as park rangers, giving them the authority to take one elk. The park hunt ends December 6th. The National Elk Refuge holds a limited-range weapons hunt to reduce herd numbers to population objectives. This year, the elk hunting season on the refuge ends December 13th.


text:
So... This really depends on age... so this is a rough theory. But...
So if you notice, everyone that died because of a bender died of FIRE bending. So what if Amon is a firebender (which could explain his superior agility, much like Mako's 'Cool Under Fire' technique) who kills people JUST SO that their loved ones may hate benders? To help him? He could be pretty old (doesn't mean that he's not a bamf. Look at Tenzin. You saw how he fought in Ep. 7) and killed Bolin and Mako's parents as a young man, later taking Asami's mother.
There are several things wrong with this theory, but there are also arguements.
1) Why would he hate benders so much if he's one himself? Maybe he doesn't. Maybe he just wants to start a war out of his own problems that don't involve bending.
2) If he's the bender behind all those deaths, why would he take his parents' lives? Maybe he didn't, and they dies of some other cause, or, like what happened with Aang when he burned Katara, Amon couldn't control his bending and took his parents' lives accidentally. This could conflict with 1, being as so: Maybe he does hate benders because he's so upset with himself for what he did.
3) He can't be lying. The Lion Turtle said that in order to take one's bending they have to be pure. Not necessarily good pure, but pure. That would mean that he has to be telling the truth. Yeah, matbe the spirits did give him that ability, but then again, on another blog of mine, what if he's just making it seem like their bending's gone?
Still, this is a rough theory, but hey, whatevs.


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"All the details were in my email. Let me go and print it out before the meeting."
"No problem, I'll send you the bill in the post."
Do either of those sound familiar? It happens in offices and other workplaces up and down the country every second of every day. Paper is being wasted all the time.
In Britain our recycling efforts have improved dramatically over the last 15 to 20 years. In the decade between 1998 and 2008 alone, the amount of household waste that we disposed of in an environmentally friendly way increased 800%.
But some of the little things that we do everyday, particularly at work, still create lots of waste. And needlessly wasting paper is one of those little everyday things.
So how can you reduce the amount of paper your business uses? The following 10 tips can help:
1. Do you really need to print that document? Do you? All of it?
It sounds simple, but don't print out something that you don't have to.
If you do need to print out something, is every single page in the document needed? If you need just two pages out of five, take the time to amend this in your printing settings. And remember if you're printing a document that's had text from the web copied and pasted into a word processing program, the formatting will be affected. Get rid of the bits that you don't actually need before hitting print.
2. It's the age of smartphones and increased connectivity- keep digital copies of things!
Store all your documents on your computers. Do you still have to keep paper copies of absolutely everything?
If you need them on the go, save them to your smartphones and tablets. More and more places, from hotels to restaurants, can take proof of a booking, for example, just by looking at your email confirmation in your email inbox on your phone.
3. Ditch those flip pads – nobody can understand your scribbles, anyway!
Flip pads are great for jotting down ideas in meetings and brainstorming sessions, but they waste a lot of unnecessary paper.
What's wrong with a whiteboard? They do the job just as well and, if you need to re-use the space, simply wipe off what you've written. Get those smartphones out to take any pictures of the notes, too. And, if you've not got the space on your wall for one, you can even get mobile whiteboards that are mounted on wheels.
4. Cancel any unnecessary magazine subscriptions
How many of those trade publications that land on your desk do you actually read?
Subscriptions are expensive. You could be saving £5 a month or more by cancelling. If you do actually read them, have you looked to see whether the publication has an online version you can sign up to, instead? They're generally a lot cheaper, contain all the same information and use no paper whatsoever!
5. If you don't use both sides of your notepad, half the notepad you paid for is wasted!
Again, this is something that many of us do on a regular basis, but why? You've filled one side of paper, you ignore the other side of it and start on a new page. What's wrong with it?
If it's just to make notes at your desk, you can make those notebooks and pads last longer by writing on both sides of the paper.
6. It's not the size that counts, it's what you do with it that matters
If you're printing out, or intend to write just a couple of lines, don't use large sized paper. If you don't have small notepads or smaller pieces of paper to hand, why not cut some larger pieces in half and put what you don't need into a scrap paper draw for next time?
7. Move to paperless bills
Help your customers and other businesses to be smarter with their paper usage by sending out bills and invoices electronically. If they do want paper copies, put them into an attached document for them to print off and let it be their choice.
8. Send more emails
Despite the decline in recent years in the amount of post that we send, sending letters out to customers, for example, is still necessary from time to time. However, if you can say whatever it is you want to say in an email, then send it electronically, instead. It's quicker and cheaper to send and, with increased connectivity, will help you to get feedback and answers back more speedily, too.
9. Consider cloud technology
Google's Drive and Microsoft's Skydrive are great free examples of collaborative programs. When working on large projects with a team of people, do you find yourself printing out lots of information and drafts and redrafts? With these two programs you can create documents, share them with your team and have live, real-time conversations whilst in the document. It's brilliant for this kind of work as it's organised, uses less paper and, crucially, is saved in the cloud, meaning you can access your saved worked from anywhere with an internet connection.
10. Nobody likes paper towels anymore
Whether in the kitchen or toilets, paper towels are never durable, make bins overflow and are never big enough, meaning you have to use more than one. Invest in hand dryers for the the toilets (you'll save money in the long-run) and, in the kitchen, just use good, old-fashioned cloths and tea-towels and wash them regularly.
How many paper sins are you guilty of? What does your business do to tackle the problem of paper waste?


text:
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DJ LEVA June 2011 remix MP3
a product of approx 35hours of work:)...basic mastering of the audio took the longest. Enjoy peeps! Download mp3 here: http://snd.sc/jWDfCD uploading this vid ...
Swiss - If Tomorrow Never Comes feat. Etana - Trailer MP3
Trailer for Swiss's second single & video off his debut solo album "Lucky Man". Shot & Directed by Tom Gould Trailer edited by Warik Blake.
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Hank Williams Jambalaya (on the Bayou) MP3
Hank Williams Jambalaya (on the Bayou) Recorded on the 13th June 1952 at Castle Studio, Tulane Hotel, Nashville, Tennessee.
Eminem - Mockingbird MP3
Music video by Eminem performing Mockingbird. YouTube view counts pre-VEVO: 14297644. (C) 2004 Aftermath Entertainment/Interscope Records.
EminemSpoken Yeah, I know sometimes things may not always make sense to you right now. But hey, what daddy always tell you? Straighten up little soldier, stiffen up that upper lip. What you crying about? You got me. Hailie, I know you miss your mom and I know you miss your dad When I'm gone, but I'm trying to give you the life that I never had I can see you're sad, even when you smile, even when you laugh I can see it in your eyes, deep inside you want to cry 'Cause you're scared, I ain't there? Daddy's with you in your prayers No more crying, wipe them tears, daddy's here, no more nightmares We gon' pull together through it, we gon'[...]
Whenua Patuwai - Midnight Train to Georgia (Official Audio) MP3
Pre-Order on iTunes now and get an instant download of 'Holding On To You' https://itunes.apple.com/nz/album/the-soul-sessions/id886510378.


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Has God called you to serve as a Bible study leader or small group facilitator?
Would you like some tips on encouraging discussion?
Maybe you're looking for some first day ideas?
Or perhaps the clock moves faster than it should and you need some help staying on schedule.
Whatever your situation, I've got some ideas I'd love to share with you.
I've compiled all of my Bible study and small group posts here – no searching or digging around the site.
May God direct your eyes and fingers to the resources you need and may He bless your time with your group.
5 Myths Bible Study Leaders Believe – Clearing up some misconceptions we may have about leading a Bible study.
6 Questions Your Women Will Have About the First Day of Bible Study – What do you women really want to know? Help them to feel welcome and loved by answering these questions before (or on) that first day.
Bible Study Leader Kit – No need to waste time hunting for an extra pencil. What supplies do your Bible study leaders need?
A Code of Conduct for Small Groups – A Code of Conduct can be used to communicate guidelines for your small group or Bible study group. Make sure your group understands the guidelines on sharing prayer requests, divisive topics, email addresses and more.
Do we have to wear name tags? – We all know each other, don't we? Reasons why those name tags are more important than you think!
Do your women know how to reach you? – Read this post before you answer! Tips for making certain your group members know how to reach you.
The First Day of Bible Study – There's so much to do! Print out this list so you don't overlook or forget anything important for the first day of Bible study.
How to Set Up and Facilitate a Bible Study Review Team – Includes a free printable to help your team review studies. This tried and true method can help your team to select your next Bible studies.
How to Stay on Schedule – Feel like there's never enough time to complete the lesson or discussion? Utilize this technique to stay on schedule.
How Women's Ministry Teams Select Bible Studies – In depth look at options for selecting Bible studies for your women.
One Thing Every Group Leader Needs to Learn – This one thing will make a huge difference in your group! Click to find out what it is!
Praying for Your Small Group – Prayers specifically for your small group. Includes a free printable.
Summer Bible Study Solutions – Do your Bible studies take a summer vacation? Women still need to be in the Word. Check out these creative ideas for making certain your women have some summer Bible study options.
Two Ways You Can Encourage Group Discussion – Do you struggle with getting your group to talk? There are two things you can do to help your group along. Click over to get the scoop!
Bible Studies
2015 Online Summer Bible Studies and Book Clubs – Some of these studies are archived on-line so they can be done anytime of year. Also a great resource for checking out studies your group is considering.
Crowned: Created for Glory, Called by His Name – A 5 week study written by Melissa Deming. Upon completion of this study your women will know crucial truths of the Bible on which they can stand when the winds of the world beat them down. They will be encouraged to walk out the calling God has placed on their lives and to live and walk in His Spirit.
How to Love Your Neighbor (without being weird) – A book with a study option written by Amy Lively . Challenge your women to love on their neighbors.
Joseph – Keeping a Soft Heart in a Hard Place – Kay Harm digs deep into the story of Joseph which shows us how to keep a soft and teachable heart during our most difficult days. Check out my review of this study.
Lazarus Awakening Bible Study – Joanna Weaver filmed the DVD session in Israel and just released this addition to the book in July 2015. Get an in-depth look inside the Bible Study kit – which can also be used as a retreat!
None Like Him – Jen Wilkin walks you through those 10 attributes of God, you'll find your finite opinion of who God is and what He is capable of expands and with it comes a greater appreciation for who God is and what He is capable of.
The Simplest Way to Change the World – Imagine what would happen if more of God's people would embrace the call to Biblical Hospitality. How would that change your neighborhood? How would that impact your community? How could it change families for eternity?!
You're Already Amazing LifeGrowth Guide – Holley Gerth will guide you through (and the women in your small group) discovering who God made you to be and it will give you the confidence to pursue His purpose for your life.


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One of the most exclusive places to be during Basel was the PPP Muzik Mansion on Palm Island, presented by Bud Light Lime Ritas & Bud Light Platinum.
It was a three-day event extravaganza also co-produced with collective Pigalle, Pompon, Pain O Chokolat to host the P to celebrate Art Basel 2014.
On the second night (Friday), the Bud Light Lime Ritas cabana got started off with DJ sets by Theophilus London and Virgil Abloh. Later on in the night we got a surprise performance by Princess Nokia and Young Lord. Also in attendance were A$AP Rocky, A$AP Ferg and Skepta.
Click below for the rest of the photos…
Photos by Ben Rosser/ BFAnyc / Bud Light


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SSC MTS Recruitment 2017. SSC Multi Tasking Staff Notification 2017 Apply Online Application form 8300 Govt Jobs. Staff Selection Commission has revealed an official notification for the posts of Multi Tasking Staff in various regions as mentioned below. So while applying aspirants need to refer their Region also. As per SSC MTS Notification 2017 the total number of vacancies issued by the organization are 8300 posts. Huge number of vacancies were issued by the Staff Selection Commission. Job Hunters those who want to make their carrier in SSC Organization this is the better opportunity for them utilize this and apply for these SSC Multi Tasking Staff Vacancy 2017. As per SSC Non Technical Notification 2017 the candidates need to possess educational qualification as need to pass matriculation/10th class from any of the recognized university. The candidates age limit should be Minimum 18 Years and Maximum 25 Years for applying these SSC Non Technical Staff Notification 2017.
Eligible candidates those who are willing to apply for SSC MTS Recruitment 2017 Notification they need to apply in the online mode of application process. Last date for submitting the SSC Multi Tasking Staff Online Application Form 2017 is 30th January 2017. As per SSC MTS Jobs 2017 the aspirants selection will be made based on written exam and interview. The selected aspirants will get pay scale of Rs. 5200 to Rs. 20200 and grade pay of Rs. 1800. Applying Job Hunters need to visit the official web page for clear Application Fee Details. The organization is planning to regulate the SSC MTS Exam 2017 on 16th, 30th April 2017 and 7th May 2017. In our website we are uploading the direct link of SSC MTS Syllabus 2017. So the aspirants need to prepare well for the exam by following the SSC MTS Exam Pattern 2017. More data about SSC 8300 Multi Tasking Staff Notification 2017 aspirants need to approach the official web page.
SSC MTS Recruitment 2017 Apply Non Technical Staff Jobs ssc.nic.in
Organization Name : Staff Selection Commission
Name of The Post: Multi Tasking Staff
SSC MTS Region Wise Vacancies:
- Central Region (CR): 325 Posts.
- Eastern Region (ER): 634 Posts.
- Karnataka Kerala Region (KKR): 666 Posts.
- Northern Region (NR): 3186 Posts.
- North Eastern Region (NER): 226 Posts.North Western Region (NWR): 534 Posts.
- Madhya Pradesh Region (MPR): 536 Posts.
- Southern Region (SR): 705 Posts.
- Western Region (WR): 1488 Posts.
Total Vacancies: 8300 Posts
Educational Qualification: Candidates need to pass matriculation/10th class from any of the recognized university
Age Limit: Candidates need to have Minimum: 18 Years and Maximum: 25 Years
Selection Process: Based on Written Exam and Interview
SSC MTS Notification 2017
Exam/Application Fee: Refer Notification
Pay Scale: Selected aspirants will get Rs. 5200/- to Rs. 20200/- and grade pay of Rs. 1800/-.
Website: ssc.nic.in
Important Dates:
- Online Application Commencement from: 31/12/2016
- Last date to Submit Online Application Form: 30/1/2017
- Last Date for Fee Payment: 17/1/2017
- SSC MTS Exam Date: 16/4/2017, 30/4/2017 and 7/5/2017
How to Apply SSC MTS Vacancy 2016 -17
Eligible and Interested candidates need to apply in online mode of application process
SSC MTS Offline Application Form 2017


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Get the real dirt on the surprising world beneath your feet during the "Dirt-O-Rama: Intriguing Tales from the Underground" summer exhibition, running June 2-Oct. 14 (free with Arboretum admission). Presented by Randy's Blue Bag Organics, Dirt-O-Rama will comprise three distinct display areas and a full round of special programming, including hands-on activities for kids and families. Here's a listing of what visitors will find at Dirt-O-Rama: 'Art of the Earth' Juried Outdoor Display, Compost Corner: Gardener's Gold, Real Dirt Lab, Clayhouse Project, and a display: Is Biochar Good for Home Gardens?
Photo by Beverly Bajus.
Photo by Ken Evans.
Which plants changed Minnesota and transformed how we live today? That was the big question behind a public education campaign led by the University of Minnesota Landscape Arboretum. U of M Horticulture professor Mary Meyer spearheaded the initiative, partnering with the Arboretum, the College of Food, Agricultural and Natural Resource Sciences (CFANS) and U of M Extension. After considering more than 100 different plants nominated by the public from early February through April 15, a panel of experts met to determine the final top ten. Plants were judged by their impact - both positive and negative - in six areas: environmental; economic or industrial; cultural/spiritual; historical; sustenance; and landscape.
The 10 Plants that Changed Minnesota are: Apples, wild rice, corn, white pine, wheat, alfalfa, soybeans, American elm, turfgrass/lawn and purple loosestrife. Read more about these choices. What do you think of the list? Share your thoughts on the Arboretum Facebook page. Look for classes, games and stories regarding the top ten plants at the Arboretum and the U of M in coming months.
Be sure to visit the Arboretum's painting and photo exhibits during your next visit: Starting June 1, and running through August 31 in the Restaurant Gallery, the Arboretum, in collaboration with the Wilcock Gallery of Excelsior, is presenting the photography exhibit: "Five Miles High." From five miles up in the air, Beverly Bajus has documented the earth's complex designs, intricate patterns in plowed farm fields, giant crop circles, rivers, streams, lakes and patches of trees.
In the Reedy Gallery, check out "Outdoor Majesty"—an outstanding collection of original oil and watercolor paintings by top-rated artists. Exhibits are open year-round during building hours and are free with gate admission.
—Gala in the Gardens. Wednesday, June 13, 6-9 p.m. An evening you won't want to miss—beautiful gardens, al fresco reception & dining, music and live auction. For more information,firstname.lastname@example.com or call 612-625-9437 or register online. Proceeds benefit the Minnesota Landscape Arboretum. * Please note that the Three-Mile Drive will close to vehicle traffic at 4 p.m. on June 13 due to set up for the Gala.
—Ladies Night Out at the Arb. Thursday, June 7, from 5:30-8:30pm. Enjoy a night out for the girls (guys welcome too!) to shop, eat, drink, and have some fun after work. Stroll the Arboretum terraces and surrounding gardens amidst vendors and enjoy music by the BZ Girls! Cash bar/appetizers available for purchase. $10/$15. As an added perk, get 10% off at Arboretum Gift Store. (*rain location is the Oswald Visitor Center) Register today.
—Auxiliary Summer Garden Tours. The Auxiliary will host their 28th annual Private Garden Tours on July 15, 17 & 18, 2012. Guests travel onboard luxury air-conditioned motor coaches. Each garden will have on hand representatives from both the Auxiliary and the homeowners to answer your questions and share their experiences creating their lovely gardens. This is truly the crown jewel of regional garden tours. Read more and register online.
—Toast and Taste in the Gardens. Thursday, July 26, from 6-9 p.m. Presenting Sponsor: UnitedHealth Group. Sample in-season, fresh, local cuisine from the Twin Cities' top restaurants and savor tastes from Minnesota wineries and breweries in the unparalleled garden setting of the Arboretum. Register today.
—Orchids for sale year round! Purchase orchids and orchid supplies from Orchids Limited of Plymouth, MN in the Arboretum Gift Store. Orchids are $20-60. Supplies include: potting bark, fertilizer and humidity trays.
—Spring Up Close and Personal: The Blossom as Watercolor Portrait Subject. Saturday, June 2, 9:45 a.m. - 4 p.m., $90 members/$95 non-members, Learning Center. Instructor: Georgia Kandiko. Register.
—Safe Plant Pest Control: IPM. Saturday, June 2, 10 a.m.-12:30 p.m., $35/$45, Snyder Building. Instructor: Dan Miller, a leading expert in IPM practices. Register.
—Wine Treatments: Fining and Finishing Wine. Saturday, June 9, 9:30 a.m.-noon, $90/$95, Learning Center. Instructor: University Enologist Katie Cook. Register.
—Hard Core Perennials: Riotous Spring Color. Saturday, June 9, 10 a.m. - 12:30 p.m., $35/$45, Snyder Building. Instructor: Paul Sotak. Register.
—Books in the Garden with Toni McNaron. Wednesday, June 13, July 11, $77/$89, Snyder Building. Join Toni McNaron, University of Minnesota professor emerita of English, in this book-club series focusing on literature that explores gardens and nature. Register.
—Travel: Northern India, November 4 - 15, 2012. There are still openings for this adventure and garden tour. See Old and New Delhi, Agra, Jaipur the Pink City and Udaipur. Contact Anna Kamrow at Carlson Wagonlit. 763-852-8119 or firstname.lastname@example.com. or contact Peter Olin at email@example.com or 952-443-1412.
Note: The Arboretum and SummerHouse will remain open during road construction on Hwy.5 this summer. During road closure, please follow detours.
3675 Arboretum Drive | Chaska MN 55318
© 2010 University of Minnesota Landscape Arboretum. The University of Minnesota is an equal opportunity educator and employer.


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Tough boss Jessica Alba
Jessica Alba is learning to "tone herself down".
The 'Machete' actress admits she is a tough boss when it comes to her eco-friendly brand the Honest Company and has even made people cry with her hard stance, but is trying to be more gentle with people.
She said: "Sometimes, I'm a little more iron fist than velvet glove. I'm straight to the point. I've made people cry.
"I have to say, 'This isn't personal. This is what needs to get done and it's just as simple as that. And... we're not crying anymore.'
"I'm learning to tone myself down."
The 'Sin City' actress - who has daughters Honor, six, and Haven, three, with husband Cash Warren - admits she doesn't know if her kids would prefer her to be at home more, but she doesn't think she could ever switch off entirely from work.
She told the new issue of More magazine: "You don't really know how [your career] is affecting [your kids] until they're adults and they say, 'You ruined my life, Mom!'
"Maybe they want me to be a stay-at-home mother who bakes chocolate-chip muffins all day... Nah. I'd probably want to start a chocolate-chip muffin company. Ya know?"
The 33-year-old actress is in a "content" place in her life and admits she feels much better than in her younger days.
She said: "Content is good because I wasn't always. I was kind of unsatisfied and angsty. It's nice shedding the angst."


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Field trip groups have been visiting Morehead Planetarium and Science Center for more than 60 years. Morehead knows how to bring science to life, with exciting and inspiring planetarium shows, Science Stage shows and Discovery Classes.
Our programming aligns with North Carolina Essential Standards, ensuring that your field trip will enhance your classroom instruction. Morehead's Guest Relations team works closely with you, so your field trip will be a great educational experience.
Reservation Process | Group Pricing | Venue Capacity
Third Party & Charter Operators | Helpful Links | Recommendations
Reservation Process
Reservations are required for ALL groups of 10 or more people.
- Complete one of the online request forms above to start the reservations process.
- Summer 2017 reservations: 6/9/17 - 8/27/17
- Fall 2017 - Spring 2018 reservations: 9/19/17 - 6/8/17
- Summer 2018 reservations will be available for request in February 2018.
Morehead's Reservations team will then contact you to discuss your reservation options and help complete your reservation.
You are welcome to call Morehead's Reservations team at 919-962-1236 with any questions.
Group Pricing
- First Program: Students $5.50; Adults $6.50 (planetarium shows or Science Stage shows or Discovery Class)
- Multiple Program Discount: $3.25 per person (for each additional same day program)
Every student and adult (educators, parents and bus drivers) in your group requires a ticket, and must be counted in your group reservation numbers. We provide one free adult ticket for every 10 students.
Venue Capacity
Seating is limited in our venues:
- 220 seats for planetarium shows
- 75 seats for Science Stage shows
- 30 seats per classroom for Discovery Class (Two classrooms are available to accommodate a maximum of 60 students per hour)
* Exhibits are not open during field trip visits.
Third Parties and Charter Operators
For field trip reservations, it is Morehead's policy to communicate directly with the school or group visiting.
If a third party arranges a field trip visit, they are financially responsible for the visit, and payment is required two weeks in advance of the visit. "Third party" is defined as a company, organization or individual (charter operator, travel agent, etc.) who is not an employee of the school or group.
Helpful Links
- 9 DOs and DON'Ts to make your field trip easier (PDF)
- e-Newsletter
- FAQs for Chaperones (PDF)
- School Resource Guide 2015-2016 (PDF) (Issuu)
- Gift Bag order form
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"And what of the Twins, were they part of this council?" "They had naught to do with us. They were slime-worse then slime-leeches that only worked for their own benefit. They had no desire to serve the Varden. Thus, they had no place in this council."
— Eragon and Sabrae
Sabrae was a female human member of the Council of Elders. She was described by Eragon to be a woman with close-set eyes and elaborately painted cheeks. She wore perfume that was thick and oily, and reminded Eragon of a rotting flower.
Role in EldestEdit
Sabrae and the others in the council, Jörmundur, Umérth, Falberd, and Elessari, wanted Nasuada to be the new leader of the Varden.


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The East York Music Festival began in 2009 primarily as a performance opportunity for students enrolled at Lippert Music Centre Inc. and has since blossomed into a local music festival open to musicians of any age and level with a wide variety of instrument and voice classes. Our mandate is to provide a comfortable and educational performance experience for the student with professional adjudication from qualified and respected musicians.
CHARLEEN BEARD – Director
Charleen holds a Masters Degree in Music Education, Bachelor Degrees in both Music and Education, an ARCT in piano, and a Grade 9 Vocal Performance Certificate from the Royal Conservatory of Music. She is the also the Director at Lippert Music Centre, established in 1957 and has had extensive experience teaching in both private and group settings, including teaching with the TDSB. As a teacher, Charleen has a keen understanding of, and enjoys working with, all levels of musicians. Her philosophy is that every person has the potential to learn and develop musicianship to its fullest, while having fun. As an administrator, her hard work and dedication has brought Lippert's to the high level of teaching and performance that it maintains today, seeing hundreds of students per week with professional, specialist teachers an integral part of the school. The School of Hard Rock Summer Camp continues to work with budding rock and teaching them what it is like to be part of a band, complete with a live performance in a local venue at the end of each week. That commitment spawned the East York Music Festival in order to further inspire local performance opportunities for budding musicians. Charleen is very community minded and is a Board Member of the Pape Village Business Improvement Area.
NEVEN PROSTRAN – Events Coordinator
Neven Prostran holds a Bachelor of Music degree from the University of Toronto and is currently pursuing a Master's degree in Musicology at Dalhousie University. He holds a Grade 8 Honours with Distinction certificate in classical guitar from the Royal Conservatory of Music in Toronto and is a two-time silver medal winner in guitar at the provincial level. Neven has been teaching music for more than 4 years at Lippert Music Centre and has helped coordinate the East York Music Festival for the past three years. His contributions to the festival have lead to increased scholarship funding as well as the creation of the annual fundraiser and gala concerts. He continues to push for more sponsorship and and scholarship funding as a way to reward performers for their hard work and dedication to perfecting their crafts.
|East York Music Festival
|Contact Us
Director: Charleen Beard


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Cheng Banzhang Taiwan Delicacy (程班長台灣美食)
Taiwanese. Flat 2, 1/F, Elite Industrial Centre, 883 Cheung Sha Wan Rd., Lai Chi Kok, 2576-1199.
Craving Taiwanese street food? Head to this no-frills eatery for authentic beef noodle soup and xiao chi, or Taiwanese snacks.
HIT A favorite of residents in the area, the place gets jam-packed most Friday and Saturday nights, but quick turnover means you won't have to wait long. You'll find most people slurping down a big bowl of beef noodle soup ($50) with two choices available, spicy or clear broth: Get the spicy option and be rewarded with an aromatic bowl of steaming, collagen-rich broth, with fork-tender hunks of beef nestled in a maze of hand-pulled noodles. Another signature dish is the Dongpo pork belly, which you can order in a bao with pickled mustard greens and cilantro ($32) or as part of a bento box with rice, minced braised pork, cabbage, dried fish flakes and a boiled egg ($45). In both, the portion of Dongpo pork is massive—a fatty, sweet and succulent piece of meat. Side dishes can be ordered three to a plate ($25) and all are worth trying, from the crisp pig's ears to fresh seaweed to cold silken tofu and thousand-year-old egg.
MISS If we're being picky, the dumpling wrappers and noodles can be a bit thick—on the tough side of al dente.
BOTTOM LINE For the bustling industrious vibe of Taipei's night markets, friendly service and authentic Taiwanese eats, this spot is the closest thing to the real deal we've found in Hong Kong.
Open Mon-Sat 11:30am-9pm, closed Sundays. $


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I've coded an EA that among other things calculates iMA from multiple time frames in order to make decisions. When I try to backtest it with the Strategy Tester I randomly get a ZERO result from the iMA function at the very first bar. I then retry it without any changes and usually after the 2nd or the 3rd attempt it does run fine until the end. Could anybody point why the Strategy Tester is not running correctly from the first time?
Thank you.
PS: I've gathered tick data using Tickstory.


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Monday, April 4, 2011
Texas Firm At Heart Of Data Breach
Irving, Texas-based Episilon, a provider of email marketing services, has suffered a major data breach, which has affected customers of Best Buy, Capital One, Citi, JP Morgan Chase, and many others. Epsilon said Monday that a subset of its clients' customer data were exposed by unauthorized entry into its email system on March 30th. Those various companies have been sending out warning emails to their clients about the breach, warning users to be on the alert for phishing and other security risks.


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WYCKOFF, N.J. – An award-winning Mahwah artist will display a collection of her paintings at Gallery 691, at the Wyckoff Family YMCA, throughout May.
Pastel artist Stephanie Cook, a Teaneck native, creates realistic, vivid images, according to the Y. Her exhibit, entitled "Awakening – A Collection of Paintings," will feature still life, floral and landscape paintings.
Cook will be at the gallery on May 3, from 6 p.m. to 7:30 p.m. for an opening reception. The public is invited to meet her, watch her create a still life painting, and enjoy refreshments.
The Y is located at 691 Wyckoff Avenue in Wyckoff. The gallery is open Monday through Friday from 9 a.m. to 10 p.m. and Saturday and Sunday from 9 a.m. to 5 p.m. For more information visit www.wyckoffymca.org.


text: ~ Energy ~ Transferring & Transforming Energy is the capacity to do work . Energy exists in many different forms such as, heat, kinetic, mechanical energy, light, potential energy, electrical and other forms. Work is measured in joules . Energy is transferred from one object to another when a reaction takes place. Energy comes in many forms ... Energy Comes In Many Different Forms ... ^ Electrical To Mechanical . Battery is Electrical & Fan is Mechanical . Chemical To Light. The Energy in the Battery is stored as Chemical Energy . Chemical Energy flow through the Wire & Lights the Bulb . Heat To Electricity . Heat From The Pot Flows Electricity To The Phone For It To Charge . Nuclear To Heat . Mechanical To Sound . Sound waves travel to any instrument . Sound to Electrical Energy . Microphone . Light to Electrical Energy . Solar Panels are Powered by the light of the Sun which bring Electricity to the House . Electrical To Light Energy . The Light Bulb . ^ Heat to Mechanical Energy . Steam Engine . Train (Mechanical) is Powered by burning coal (Heat) .


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Way to give, Georgia! Our 2016 campaign raised a record $3.9 million and the giving continues. Click to see our prize winners.
Our next Georgia Gives Day is November 16, 2017. Click here to register your nonprofit.
Future Foundation, INC
Raised: $0Remaining: $250
When Future Foundation asked students ages 13 and 14 in urban Atlanta neighborhoods about their future, 95% believed they would graduate from high school and 90% believed they would graduate college. In reality, less than half will actually graduate high school and less than one-third will attend college.
Future Foundation's mission is to level the playing field for metro-Atlanta youth by providing quality education, health and life skills programs, and its impact has been amazing! Please support our mission by making a donation today.
• Your $5 gift sponsors one day of tutoring and homework support.
• Your $40 gift sponsors one week of after school tutoring.
• Your $80 gift sponsors two weeks of tutoring.
• Your $150 gift sponsors one month of academic coaching.
How Do They Do It?
As a nonprofit organization (501(c)(3)), Future Foundation directly serves over 1,000 students in grades 5-12
through several programs.
• RealTalkATL, as featured on CNN (clip), sparks conversations about healthy choices regarding
sex, love, dating and relationships through partnerships with area under-performing schools and
community centers.
• The Reef House Learning Center for 5th-7th graders and the Reef Teen Center for 8th-12th graders
are supervised, secure environments where experienced staff and certified teachers cultivate an
atmosphere of excellence in academics, health and leadership. Many of the youth served are at risk
because their parents and grandparents were at risk.
• Future Foundation takes a holistic approach by empowering parents to engage in their youth's
success through its Parent Connect program.
How Can You Help?
Future Foundation is making a significant difference in the lives of metro-Atlanta students, their families
and communities. Here's how you can support our mission and help spread our message of hope, optimism,
courage and community.
Donate Today. Future Foundation needs public donations to provide these programs. 100% of board
members made personal donations last year, but they are not enough. Please consider supporting us by
making your own donation.
Join the Be a Hero campaign. Spread the word about what we are doing! Forward this email on to your
friends and family and take the time to tell them about Future Foundation. Visit https://www.facebook.com/
FutureFndation to join our Be a Hero campaign and help spread our message of hope, optimism, courage
and community.
Mary Frances Jones
is fundraising for Future Foundation, INC
I'M A FUTURE FOUNDATION HERO. I'm empowering metro Atlanta youth by supporting the Future Foundation, whose mission is to provide quality education, health, and life skills programs to at-risk kids and their families.
Join the 100% Circle Investors, or give at another level that is meaningful to you.
$50 - A little goes a long way!
$100 - Contributes to a 8 week summer long of field trips for a student!
$500 - Covers snacks for one month for two of our afterschool sites!
$1000 - You become a 100% Circle Investor, securing the futures of Atlanta's most vulnerable youth!
$ Other :
Make this donation:
Whether you have $10, $100, or $10,000 to give,
it all adds up! All donations to the 501(c)(3)
participating nonprofits on this website are tax-deductible.
Support questions?
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Residential Land for Sale
- About this property
- Explore Sandy Creek
1321m² of Prime Land to Build your Dream Home!Property ID 1482862Petra Mells of Ray White Port Adelaide is proud to present this desirable parcel of land in a new subdivision situated at the foothills of the Barossa Valley.
This ready to build on parcel of land, (Lot 9) situated near the end of a cul-de-sac, is approximately 1,321m2. With views of rolling hills and set among other newly built homes, you have the flexibility of choosing your own builder. Take advantage of government grants and save on stamp duty!
Feel like a hit of golf? The well renowned Gawler Golf Club is just up the road. Wine tasting or perhaps a getaway? The Barossa Valley and the beautiful Novotel Barossa Resort are just minutes away. It's all about lifestyle!
Sandy Creek is a quiet, thriving town that offers a fabulous country lifestyle with a strong community vibe. A short drive down the Barossa Valley Highway leads you to the Gawler Township which offers shopping, public transport, public and private schools, a hospital and other amenities. Aside from the fantastic golf course, the town offers the historic Sandy Creek hotel, Sandy Creek Primary school, and sports oval.
A fantastic opportunity to build your dream home with plenty of space for a nice big shed, pool or anything that your heart desires! (STCC). Contact Petra to discuss!
Disclaimer: Neither the Agent nor the Vendor accept any liability for any error or omission in this advertisement.
Any prospective purchaser should not rely solely on 3rd party information providers to confirm the details of this property or land and are advised to enquire directly with the agent in order to review the certificate of title and local government details provided with the completed Form 1 vendor statement.


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My O My.. Best Thai Beef Salad Ever!
Recipe by KitchenManiac
This is one of the best Thai salads I have ever tasted and I just had to share it with my zaar family. Try it, you won't regret it. You can substitute the beef with the same amount of Pork fillets, chicken breasts or thigh fillets, or some firm tofu. When preparing this salad in advance, cook the beef, prepare the salad, and make the dressing, BUT STORE EACH IN SEPARATE CONTAINERS. Do NOT combine until you are ready to serve. This is an ideal portable lunch or picnic dish that can be transported in 3 small containers, and assembled on the spot.
Top Review by Chap Heng
I must say that this is a wonderful recipe. When I made this the first time I had a taste of the dressing just to make sure and I thought I was headed for a disaster given its weird taste, a sourish and saltish flavor. But when I started tossing the greens together the aroma of the different spices was heavenly! When I combined the greens and the dressing, the taste was wonderful! I was so wrong about the taste! I've replaced beef with roast chicken and it tastes just as great. I made this for a party and separated it into three parts since I have vegetarian friends coming over and they loved it! It makes a great vegetarian salad.
See Discussion:35 Reviews 6 Tweaks
Ingredients Nutrition
- 30 ounces sirloin steaks, trimmed (rump or fillet)
- 7 ounces salad greens (any kind)
- 2 small red onions, finely sliced
- 10 kaffir lime leaves, shredded
- 3 large mild red chilies, seeded and shredded (can add more if you like a BIG punch)
- 2⁄3 cup cilantro leaf (coriander)
- 2⁄3 cup mint leaf
- 2⁄3 cup basil leaves
- 1 teaspoon soya sauce
- 2 tablespoons fish sauce
- 2 tablespoons lime juice
- 2 tablespoons brown sugar or 2 tablespoons palm sugar
Directions See How It's Made
- Brush the beef with a little oil and char-grill, barbecue, or pan-fry till cooked to your liking.
- (I recommend medium rare for this recipe, if you can handle a little blood.) Set aside for five minutes and slice it thinly.
- Place salad greens, onions, kaffir lime leaves, chili, cilantro, mint and basil into a salad bowl and toss lightly.
- To make the dressing, combine the soy sauce, fish sauce, lime juice and sugar.
- Stir the dressing well.
- Place the beef on the salad and pour over the dressing.
- Serve immediately.


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Feb. 13, 2004
BOISE, Idaho - The Wyoming Cowboy wrestling teamhad its five dual win streak come to an end Friday night in Boise,Idaho as the Boise State Broncos defeated the Pokes 24-11. The Broncoswon three of the final four matches to secure their seventh victory ofthe season. With the loss, Wyoming is now 7-4 on the year.
The Cowboys were without three of their starters on Friday. SophomoreBryce Leonhardt at 125 pounds, senior Blake Gunter at 141 pounds andsophomore Patrick Shuler at 149 pounds were all out nursing injuries.The Pokes were forced to forfeit the 141 and 149 pound matches andstarted the dual behind 12-0.
Wyoming would get on the board in the third match of the night assenior Andrew Shuler, ranked 16th in nation, improved his overallrecord to 22-5 with a 4-2 victory over Ben Cherrington of Boise State.Shuler has now won nine of his last ten matches.
Senior Levi Prevost, who has been out for over a month with aninjury, returned to the lineup for the Pokes on Friday night. However,his return did not turn out the way he wanted. Prevost suffered hisfourth loss of the season as Russell Brunson of BSU took the 165 poundmatch by a 10-8 decision to make the score 15-3 in favor of theBroncos.
Wyoming would pick up match wins in the 174 and 184 pound bouts.Senior Trevor Murray defeated Jonathan Carisle of Boise State by a 6-4decision while sophomore Sam Wendland edged out Casey Phelps 3-1 tocut the Bronco lead to 15-9.
The most anticipated match of the night was the 197 bout as 12thranked K.C. Walsh of Boise State and 16th-ranked Kevin Kessner ofWyoming battled it out for national exposure. Going into the finalperiod Kessner and Walsh were tied at 2-2, Walsh recorded theperiod's only takedown with 1:00 remaining which proved to be thedeciding factor. Walsh took the match by a 5-3 decision.
Wyoming would win just one of the final three bouts. HeavyweightDusty Hoffschneider, ranked 16th in the nation, won in dramaticfashion over Jacob McGinnis. With under one minute remaining in thefinal frame Hoffschneider scored an escape point to take the lead andthen the match 5-4. Hoffschneider is now 7-3 on the season.
The Broncos were able to put the dual away with wins in the final twoweight classes. Clint Wofley won the first of those two matches with a10-8 decision over UW's Barrett Duell at 125 pounds, before ScottJorgensen ended the night's action with a 14-2 major decision overCowboy Tyson Shatto.
Wyoming will be back on the mat Sunday, Feb. 15th, when they hostCal-State Fullerton in Laramie. The dual is set for a 1 p.m. start inthe MultiPurpose Gym.


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I posted this in the T-Mobile specific forum, but I don't think many people will be seeing it there... lol.
Updated to 10.2.x this morning, from 10.1.x, and since I updated:
- My vibrate doesn't work for incoming texts (works with calls)
- My lock screen doesn't exist, even after verifying through the settings that it should lock with no delay
- My Mobile Data is half-*** at best - Facebook works and I can download/send mms, but no actual internet usage (Play Store, Chrome for example)
- WiFi has same exact issue as Mobile Data - only Facebook works
- Sincerely hate the camera and am wondering if I can go back to the 10.1 version of the camera (or if anyone has a link to where I can find it)
Any suggestions or fixes that anyone knows about, or is anyone else having, or had, these issues when upgrading? XDA seemed to have the typical "GO READ 1,000,000,000 THREADS AND MAKE THE ANSWER APPEAR FROM THIN AIR, NOOB!!!!1111!!"


text: Got a couple of things in the other day and took some photos to share. For my iPad2, I'm waiting with many others here, for my Portenzo case. But in the meantime, I needed something good to travel with my keyboard (BT). Something that can hold my iPad in it's future Portenzo case in a good sized bundle for traveling or commuting to work. So for that, I went with Waterfield's (SFBags) iPad wallet. To protect the back of my iPad2, I chose Dodocase's bookback for the iPad2. Got one for myself and my wife's white iPad as she really likes to just put her iPad just about anywhere. Enjoy the photos. Hoping the linking from my Flickr pages work okay here - crossing fingers! Oh yeah, the iPad wallet will even fit my 11" MBA!! I'm just linking a couple of images but I took a bunch so will also just post the link to the set. Full Set of Images http://www.flickr.com/photos/wuperruper/sets/72157626320596569/ Mike


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Let us know when your receive great advice so we can thank our lawyers and point others with similar questions in the right direction.Got it!
Possible personal injury and discrimination case. How to find the contingency attorney ?
I live in Southern California
There are many attorneys here on AVVO in the LA area. Use the Find a Lawyer search tool. Good luck!
I am licensed in California only and my answers on Avvo assume California law. The above answer is for general information only and is based on the information you posted. Every case is fact dependent, so to get a thorough analysis of your situation, you will need to consult face to face with an attorney licensed to practice in the jurisdiction where the incident took place. Do not conclusively rely on any information posted online when deciding what to do about your case. No attorney-client relationship shall be created through the use reading of this response on Avvo. You should never delay seeking legal advice, disregard legal advice, or commence or discontinue any legal action because of information in this response.Ask a similar question
You can use Avvo's "find a lawyer" tool. Good luck.
Only 29% Contingency Fee! Phone: 215-510-6755 www.InjuryLawyerPhiladelphia.comAsk a similar question
Another good referral for employment lawyers is CELAweb.org
David Mallen
310.895.0107 cell phone
David A. Mallen offers answers on Avvo for general information only. This offer of free, general answers is not intended to create an attorney-client relationship. If you need specific advice regarding your legal question, you should consult an attorney confidentially. Many experienced California labor and employment attorneys, including David A. Mallen offer no-risk legal consultations to employers and employees at no charge. David A. Mallen is licensed to practice law before all state and federal courts in California, as well as the California Labor Commissioner and the California Unemployment Insurance Appeals Board. Failure to take legal action within the time periods prescribed by law could result in the loss of important legal rights and remedies.Ask a similar question
You may call your local county bar association and ask them for a list of attorneys that do this type of work, and offer a free consultation. I also offer a free consultation.
Ajay Kwatra, Esq.
(858) 539-1820
You may also have a workman's compensation case if the injury occurred at work. You should consult with a lawyer promptly.Ask a similar question
Dear Poster,
I am sorry you are the victim of personal injury and discrimination. I think what you are asking is not "where do I go to search for an attorney," but rather, how to find the right attorney.
The right attorney, in my experience, is one that provides you with guidance, time, and understanding. If you contact lawyers, you should gauge how much attention the lawyer (not his/her assistant, staff, paralegal, etc.) gives you. Unfortunately, many lawyers are overwhelmed with work, and are not able to give clients personalized attention. However, a good relationship between lawyer and client is always important, and leads to lessen the chance that there is a disconnect between the client's expectations and the outcome of the case.
My recommendation is that you consult with 3-5 lawyers, and see which one you like best. You can do consultations over the telephone or in person, or video-conference, if the lawyer has a sopihisticated law office. Consultations should be free, and for this type of case, you should not be expected to pay for costs.
I have represented numerous personal injury and discrimination clients. If I can be of help, let me know. My contact information is below.
Rabeh M. A. Soofi
Los Angeles | California
Phone: 213.632.9390
Fax: 213.986.3485
Email: firstname.lastname@example.com
Web: www.rabehsoofi.com
Twitter: @rabehsoofi
*** ATTORNEY ADVERTISING MATERIAL *** I am providing you with general comments, not legal advice. Nothing in this answer creates an attorney-client relationship nor constitutes legal advice, as I do not know the facts of your case well enough to be able to guide you, nor am I making any promises about the outcome of your case, or any guarantees about my capabilities, skill level, or predicted success. If you would like to retain me to provide you with legal advice, please contact me and we can discuss the engagement.Ask a similar question
Post a free question on our public forum.Ask a Question
- or -
Search for lawyers by reviews and ratings.Find a Lawyer


text:
Creatine kinase or phosphor creatine kinase is a useful enzyme found predominantly in the tissues of all the organs of a human body system. Creatine kinase levels in normal individuals range between 10 to 80 units per liter (females) and 17 to 150 units per liter (males). Creatine blood tests performed at various labs not only evaluate the levels of creatine in the blood but also serve as an indicator for the underlying disorders that have still not become evident. For instance, lower levels of creatine kinase may reveal the presence of an underlying alcohol liver disease and rheumatoid disorder. An abnormally high level of creatine kinase reflected in the blood test is indicative of a detriment to any organ of the body, especially the ones related to muscles and brain.
Go for the most current and the most preferred treatment of statin-induced myopathy. The procedure marks a slight increase of creatine kinase level in the first few hours followed by a steep decline in the level of creatine kinase.
Opt for the beta blocker treatment option for treating long-term higher levels of creatine kinase. The beta blocker treatment works more effectively when used in the initial stages of rise in creatine kinase levels.
Temporarily avoid the intake of diabetic medications, until the creatine kinase levels reach the normal range.
Tips & Warnings
- High creatine kinase levels can also be witnessed in the case of neurological disorder hyper-CKaemia, a condition that can be examined by undergoing a regular neurological examination.
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text:
The most potentially impactful personnel move this offseason may have been the Seattle Seahawks' acquisition of Percy Harvin.
Harvin's dangerous level of perimeter quickness potentially serves as a great change of pace to Marshawn Lynch's inside power rushing. He also could add much-needed intermediate-level route depth help to an offense that needed an upgrade on those types of throws (12.9 yards per attempt on medium-depth passes last year, tied for 16th).
From a fantasy perspective, this collection of skills was seen as a potential boon to quarterback Russell Wilson and explains why a quarterback who finished 11th in fantasy quarterback points last year is currently averaging a No. 8 overall quarterback draft ranking in ESPN live drafts.
Now that Harvin could be out for a while with a hip injury (he's getting a second opinion next week in New York), it has to be expected that Wilson's fantasy value will decline by enough that he should start falling back in those same draft rooms.
But a closer look at this situation shows that even if Harvin misses extended time, while damaging from a team perspective, it should not have that big of an impact on Wilson's 2013 fantasy football prospects.


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VCP Jangaon
Vikas College of Pharmacy
Andhra Pradesh
Total Students
Fees Range
How to reach
Vikas College of Pharmacy is situated at Shameerpet road, Jangaon.-506167, Dist: Warangal, Andhra Pradesh, India. in Jangaon.
Courses Offered
- 4 Years
- B.Pharma
- Medicine / Beauty / Health Care
- Rs. 75000 (Annually)
Vikas College of Pharmacy - VCP Jangaon - VCP
Vikas College of Pharmacy is sponsored by the Jangaon Vikas Education Society, Jangaon. It is the maiden venture of the society. The college works under the dynamic leadership of its chairman Sri. V. Prasada Rao who has got other successful avenues to his credit. The Jangaon Vikas Education Society is formed with a clear vision to enhance the awareness and expand the job opportunities in a profession like Pharmacy & Pharmaceutical Industry. As the health of the People at large has become a major agenda of the International and National agencies across the globe, there is a dire need to produce many more professionals in Pharmacy. In this regard, to cater the needs of the students of backward rural area, who cannot afford to go out, the Jangaon Vikas Education society committed itself to provide an opportunity to these sections of the society to have Pharmacy Education in their proximity. Vision is realized only when sufficient infrastructural facilities are provided to the inmates. To attend this, Society had built sophisticated infrastructure. The society has also acquired with Laboratory and Library facilities to the optimum level. In addition to all these, land which is selected by the society is easily accessible for the students coming from different corners. Further the land is quite garden and land spaces will be developed for the congenial environment.
Nearby Hangout
|Food & Entertainment
|Health & Grooming
|Shopping / Daily Needs Shop
|Bank / ATM
|* Information provided by students
Why join Vikas College of Pharmacy Jangaon
The college has well furnished infrastructure facility.
1 Type Courses Available
- 1 UG Courses
Vikas College of Pharmacy Placements
Visiting Companies
Student Placement
At Vikas College of Pharmacy (VCP) the students are endowed with all convenient amenities that make their life 'go easy' in college hours, alongside make learning more interesting. Some of the facilities include well ventilated classrooms, recreational areas, hostel facility for boys and girls, indoor and outdoor games, stocked library, seamless internet/wifi connectivity, medical facilities etc.
Nearby popular spots within 5 KM from the campus
|Swarna Kalamandhir (Movie Theater)
|Krishna Kala Mandir (Movie Theater)
|Vinuthna Orthopedic hospital (Hospital)
|Ravali Nursing Home (Hospital)
|Adharsha Physiotheraphy Clinic (Hospital)
|Om Sai Hospital (Hospital)
|Dist Coordinater Hospital Service (Hospital)
|Vijaya Hospital (Hospital)
|Manikanta Bakery (Bakery)
|Andhra Bank (Bank)
|State Bank of Hyderabad (Bank)
|Indian Overseas Bank (Bank)
|Canara Bank (Bank)
|DCB Bank (Bank)
|ICICI Bank (Bank)
|HDFC Bank (Bank)
|HDFC Bank Branch / ATM (Bank)
|State Bank of India (Bank)
Try our extensive database of FAQs or submit your own question...
B. pharma Shubham Kumar Asked this 1 year, 2 months ago - India
admissions for b.pharm Anonymous User Asked this 1 year, 1 month ago - India
Admission in Govt Medical Lab Technology College Ayesha Sultana Asked this 11 months ago - India


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Map Price
You have no obligation to purchase the product once you know the price. You can simply remove the item from your cart.
You have no obligation to purchase the product once you know the price. You can simply remove the item from your cart.
- Description
- Charge new wireless charging batteries anytime and anywhere without ever having to remove from your tool
- Mounts to any flat surface for quick and convenient access anywhere you need it
- Lithium-Ion battery will work down to -4 Degrees Fahrenheit
- Integrated battery fuel gauge for fast and easy charge status
- Compatible with Bosch Wireless Charging Batteries
- Full details
Tap into the confidence and flexibility of Bosch Wireless Charging. Create your optimal charging set up - in between tasks, where you store it, or even as you drive between jobs. Be power ready, anytime, anywhere. The WC18CF-102 Wireless Charging Starter Kit gets you started with the new wireless battery charging experience from Bosch. The new 18-Volt Wireless Battery Charger provides charging anytime and anywhere without ever having to remove batteries from your tools. The 18-Volt Wireless Charging Frame fits around the wireless charger to ensure that your battery is properly aligned with or without the tool. Easily mountable to any shelf or sidewall for vertical and horizontal storage to charge your batteries quickly and conveniently. The new 2.0 Ah 18-Volt Wireless Charging SlimPack battery offers more run time and 2x longer life with unique Cool Pack technology. The advanced heat conductive housing keeps the battery cooler for long life. An integrated fuel gauge makes checking the charge status quick and easy. Works well in cold weather, even in temperatures down to -4 Degrees Fahrenheit. The WCBAT612 is compatible with all Bosch 18-Volt Lithium-Ion power tools.
- (1) WC18C 18-Volt Wireless Battery Charger
- (1) WC18F 18-Volt Wireless Battery Frame
- (1) WCBAT612 18-Volt Lithium-Ion SlimPack Wireless Battery.
- Specifications
Festool Compatibility N/A Is Manufacturer Set N/A Package Quantity N/A Battery Voltage 18 V Battery Capacity N/A Product Type Battery Specifications N/A Preorder Date N/A Product Special Message N/A
- Warranty
Power Tools: 1-Year Limited Warranty
Measuring Tools: 2-Year Limited Warranty
For detailed warranty information, please visit the Bosch website.