text:
Pitching is plentiful in NL only
When a pitcher throws a no-hitter, everybody notices. When
a bunch of pitchers throw low-hit games, fantasy owners pay attention.
Boston's Derek Lowe captured the headlines Saturday with
a no-hitter at Fenway Park, but it was just one of many excellent pitching performances
that day, including one-hitters by the Mets' Pedro Astacio and the Yankees'
Ted Lilly. But it seems good pitching performances have been more plentiful
this season. Have they?
Let's take a look at how this April is taking shape:
The American League ERA, through Saturday, was 4.70
up from 4.47 in 2001.
In the National League, however, pitchers are going nuts.
The ERA is 3.86 down from the 4.35 league ERA of 2001 and also down a
few notches from last April's numbers.
So last year we were talking about how the AL was catching
up to the NL in pitching. Let's get that thought out of our minds right now.
The NL is where the pitching is, even if Greg Maddux got shelled and Kevin Brown
has a balky elbow.
If you think you're getting good pitching but you're still
not moving up in the standings in your NL league, here's who you should blame:
The Cincinnati Reds' pitching staff. The Reds had a 4.77
ERA last season; through Saturday it was 3.47. Will this last? No. The bullpen
is solid, and Elmer Dessens is a keeper as a starter. After that, no thanks.
The Pittsburgh Pirates. They've gone from 5.05 to 3.66.
No question, the Pirates have better arms with Josh Fogg, Kip Wells and Dave
Williams. But given the Pirates' shaky offense, they won't be impact fantasy
Montreal has gone from 4.68 to 3.78. Everybody except for
a few owners and prominent MLB officials are rooting for this to continue.
San Diego has gone from 4.52 to 3.53. We knew it was a
pitchers' park. We didn't know how tough Brian Lawrence would be or how much
Brett Tomko would benefit from the change of scenery back to his hometown.
Then there are the Mets. We were concerned when they traded
Kevin Appier: Did the Mets give up too much pitching in their pursuit of offense?
Well, they had a 4.07 team ERA with Appier last year. This year it's 2.56, and
that's not a typo.
Thank goodness for the Colorado Rockies, who despite
the efforts of John Thomson give us a sense of normalcy with a nice 5.00-plus
I really liked that second tier of pitching, especially
in the NL, heading into 2002, and that tier has gotten huge.
The top tier is not deep 6 feet, 10 inches to be
exact. It's just Randy Johnson.
The second tier, where we find great numbers with small
reputations and smaller price tags, now has these new names: Livan Hernandez,
Odalis Perez, Tomko, Lawrence, Astacio, Dessens, Fogg, Jeff D'Amico (after a
year's absence), Rusch, Vicente Padilla, Kazuhisa Ishii, among others
to go with new stars Matt Morris, Roy Oswalt, Brad Penny, A.J. Burnett and Javier
We're seeing not only a lot of help from unexpected sources,
but also the absence of true ERA torchers that we saw last season.
So get ready for a tough race in the ERA and WHIP categories
good might not be good enough.
LOTS OF SOCK: The Chicago White-hot Sox are approaching
Colorado status as a team that will make you bench your pitchers who have that
team on their schedule unless they're facing Oakland, that is.
The White Sox, at or near the top of the league in most
offensive categories and with a relatively small number of strikeouts, will
be terrorizing Texas and Anaheim pitchers May 6-19. Plan accordingly.
Speaking of the White Sox, how about this quirky, only-in-April
stat: Ace and $20 Roto pitcher Mark Buehrle gave up as many earned runs in one
bad outing (eight in 2 2/3 innings against Oakland
on Saturday) as Houston's Dollar Dave Mlicki has given up all season, in five
TOO MANY PITCHERS: Where have all the free agents
I lost Dmitri Young to a hernia last week in the Leagues
of Alternative Baseball Reality and needed a corner man as a replacement. I
had one option: Enrique Wilson. Either that, or eat bagels with Young still
in the lineup.
Now, our league is standard Roto 12 teams of 14
hitters each with a six-man reserve squad. So why is there nobody, or
close to it, available?
Twelve-man staffs. At last count, 18 teams were going with
the extra pitcher, leaving precious few extra hitters.
This latest trend means balance is more valuable than ever
to a fantasy offense. If your team is only as good as your worst guy, then,
well, you might not have a very good team.
SOME GAIN FOR THE PAIN: With many players getting
hurt, some mysteriously and others Mike Piazza, Gary Sheffield, etc.
maddeningly staying off the disabled list, injury information is more
in demand than ever.
Rick Wilton of the Baseball Weekly hot sheet (hotsheet.rototimes.com)
is an injury guru, and you might want to check out another well-informed source
for medical musings, Will Carroll's "under the knife" forum at www.netshrine.com/vbulletin2/forumdisplay.php?s=&forumid=18.
When you have your health, you have everything.
But when you don't, information always helps.
Fantasy mailbag
Previous question: Which slow-starting players are you
"cutting bait" on?
Looking for a better lead
I cut the string on Dave Roberts, who's been poor at best
for a leadoff hitter. The only question remaining is ... how much longer do
the Dodgers wait until they give Marquis Grissom the full-time job? A close
second, if I owned him, would be Adam "sophomore jinx" Dunn. You gotta be able
to hit the breaking pitch at the major league level.
Jim Mason
Bellefontaine, Ohio
An exercise in futility
This seems to happen every year to me. I draft a great
squad, and my studs end up hurting me more than $1 players. Last week, I decided
to give each of these guys one more week before I cut bait: Rafael Furcal, Jason
Kendall, Reggie Sanders, Morgan Ensberg, Fred McGriff, Terry Adams, Kip Wells,
and Toma Ohka. Almost all of them stepped up and produced. The sum of this group
was less valuable than two $1 players on my squad: Eric Gagne and Odalis Perez.
Terry Adams has one more start to show signs of life.
Pete Renneker
Dayton, Ohio
One fish to throw back
Funny you should ask who I want to "cut bait" on; Rex Hudler
often referred to Tim Salmon as "Kingfish" during the Angel broadcasts. My team
can wait no longer for the bulked-up right fielder to turn around his poor offensive
numbers. His batting eye appears to be slipping, as seen through his walk-to-strikeout
ratio. This "kingfish" can wash ashore to be devoured.
Ken Magner
Freehold, N.J.
New exes in Texas
I have to admit that although it looked like he could flourish
in that Texas lineup, I am looking to "cut bait" on Carl Everett. Perhaps we
can chalk this up to his bad knee. I was trying to convince myself of that,
but now that he has openly declared his unhappiness at being moved to right
field in deference to his balky knee, it's time to stick a fork in Carl. If
it's possible for a player to have a negative impact on the "clubhouse" of your
fantasy team, Carl's your man.
Ron Lambert
Providence, N.J.
Next question: What is the most insulting trade offer
you've received so far?
E-mail John Hunt at email@example.com


text:
Diageo Plc. (NYSE:DEO) is reportedly eyeing the buyout of world's leading tequila producer Jose Cuervo. The owner of Smirnoff vodka, Diageo has valued Jose Cuervo at $2 billion for the acquisition.
London-based Diageo, and producer of premium quality spirit under famous brands such as Johnnie Walker whisky, already enjoys distribution rights for Jose Cuervo.
Diageo may have to compete with companies like Bacardi, Pernod Ricard and Brown Forman (NYSE:BF.B) who might be interested in the acquisition of Jose Cuervo. However, the spirit giant is in a much sound position as it already owns the international distribution rights for Jose Cuervo.
The Jose Cuervo Golden Margarita, marketed by Diageo PLC, ranks number one in the category, which generated about $218 million in sales at retailers over the past year. Cuervo and Diageo had signed a joint venture in 2003, with the former paying $100 million for a 50 percent stake in Diageo's Don Julio tequila brand. Diageo launched a national marketing campaign under the name 'Cue the Cuervo', for the Jose Cuervo tequila across the US. The campaign displays Cuervo as a night-time party drink in both the off- and on-trade.
Diageo is on an acquisition spree presently. According to company sources, management froze share buybacks in order to divert funds for takeovers based on the firm's reliance on European and North American markets. Last month, Diageo had agreed to buy Turkish spirits maker Mey Icki for $1.3 billion while it has also been linked to one of Poland's largest vodka companies, Stock Spirits, selling under brands like Czysta de Luxe.
After the deal in Turkey is completed, more than 35% of Diageo's revenues will come from emerging markets. The group has a strong presence in Africa and in Latin America and management predicts that in four to five years the company's emerging markets' revenue share will exceed over 50%. The biggest potential takeover targets in Diageo's sights are American and French spirit companies.
Currently, we maintain a Neutral rating on the stock. Further, Diageo holds a Zacks #3 Rank, which translates into a short-term Hold rating.

subset: commoncrawl


text:
She found it funny that in end she lost her virginity to her first boyfriend.
The irony was not lost on her that she had been told 'I love you' twice at a Firelight Festival, but wasn't able to say it back either time.
She told Logan she loved him before he told her. She didn't want to get caught off guard again.
She often wonders why she said 'no' when she wanted to say 'yes.'
The first time she was told 'I love you' she didn't reply because she didn't know how she felt.
The hidden look of disappointment on his face when he saw what her life had come to made her want to change more than anything else.
She hasn't participated in a Stars Hollow Basket Auction in over five years.
The second time she was told 'I love you' she didn't reply because she never had the chance (he had run away too fast).
Farewell to Arms became a close second on her favorites list when she was seventeen years old.
She hasn't walked over their bridge since she went away in college.
Although she would never say it out loud, one of the reasons she hoped her mom and Luke would work it out was because she was sure Jess would come to the wedding.
Farewell to Arms used to be on her hated list. (Despite everything, The Old Man and the Sea still was)
Whenever someone says, "It is what it is," she is overwhelmed with an unexplainable sadness. She pretends she doesn't know why.
She doesn't read books for pleasure anymore…
She also pretends she doesn't know why she's interested in getting a newspaper job in Philly.
…Maybe it's because every time she finishes a good book she asks in her mind, "I wonder if Jess has read this one?"
Her new number one spot is filled by The Subsect.
She found it funny…
Half of her wants to show up at Trucheon Books and ask for his autograph.
He was one of the three people she believed never once doubted that she could all of her crazy dreams. (the other two were her mom and Luke)
…that despite everyone's warnings…
He taught her the best way to eat fries.
She was one of the two people that Jess actually believed when she said he could be something more.
…that he was the type of guy who was only after one thing…
Other than her mom, he was the only one who knew how to fix her coffee on exam day, that she despised roses and loved sunflowers, and that strawberries were best served on chocolate ice cream.
… that he was the only one of her boyfriends she hadn't slept with…
No one noticed that she had cut her hair short exactly six months to the day after Jess had disappeared.
The smell of cigarette smoke used to make her sick to her stomach. Key words, used to.
…or got to tell him she loved him…
The irony wasn't lost on her that when she finally realized that he was the guy for her, it was probably the first time since they met the he didn't want to be with her.
Key word, probably.
Part of her (the same part that wanted to get his autograph) wanted to find out if that were true. Another part, the part that controlled her, was glad that she didn't.
Aki- I don't know what this is, it just is. It came to me and I wrote it, that's all I know. If you like this I'm thinking of adding a second chapter or companion piece in a similar style but from Jess's pov.


text: WRC-15 recommends reserving spectrum for public safety broadband27 Nov 2015 10:46 AM World Radiocommunication Conference delivers first recommendation in the history of the ITU-R for a global harmonised spectrum range for mobile broadband services to support the Public Safety and Emergency ServicesThe critical communications community has welcomed a decision taken at the 2015 World Radiocommuniction Conference (WRC-15) to recommend reserving spectrum for public protection and disaster relief (PPDR). The move is unprecedented for the ITU-R, which runs the WRC.The increasing need for harmonised frequency ranges for PPDR communications has been recognised in a highly significant resolution agreed by the 196 nations participating in the 2015 World Radiocommunication Conference concluding this week in Geneva.Harmonised spectrum for critical communications enhances interoperability and cost effective cross-border collaboration, resulting in more effective response during disasters and major events. The WRC 2015 Resolution 646 takes into consideration 'the growing telecommunication and radiocommunication needs of public protection agencies and organisations, including those dealing with emergency situations and disaster relief, that are vital to the maintenance of law and order, protection of life and property, disaster relief and emergency response.'The Resolution 646, which is an international agreement under UN/ITU, encourages administrations to use harmonised frequency ranges for PPDR to the maximum extent possible, and to consider the frequency range 694-894 MHz when undertaking national planning for PPDR applications, highlighting broadband in particular. This underlines that although narrowband and wideband systems will continue to be used to meet PPDR requirements, there is a growing need for broadband applications to support improved data and multimedia capabilities. These require higher data rates and higher capacity, and appropriate spectrum from this harmonised range may need to be made available on a national basis.The WRC Resolution 646 recognises that many administrations wish to promote interoperability and interworking between communications systems used for PPDR, both nationally and for cross-border operations in emergency situations and for disaster relief.Clearly defined frequency ranges enable improved spectrum management and planning. Harmonised spectrum increases the potential for interoperability and standardisation of equipment. The resulting economies of scale in terms of research, development and manufacturing lead to a more cost-efficient and competitive market."In today's world, the need for cross-border cooperation among PPDR agencies has never been more apparent," said Phil Kidner, CEO of the critical communications sector's representative organisation the TCCA (TETRA + Critical Communications Association)."Many, many organisations responsible for delivering and supporting PPDR emergency response have been working for several years to secure harmonised spectrum for critical broadband applications. We would like to thank the spectrum regulators of the world for this Resolution – it is a treaty between the 196 UN countries and therefore a very important global step," said Kidner.The Resolution 646 is a significant first step and efforts on both regional and national levels are needed to reach the objective – internationally harmonised spectrum is dedicated at national level. Several countries have allocated spectrum already, including Australia, Canada, France, Korea and the USA. Each of those took the decision as direct result of natural disasters or terrorist attacks, and all are in alignment with this Resolution.For Europe, the next step is for the CEPT (European Conference of Postal and Telecommunications Administrations), which represents 48 European countries, to complete the ongoing work and reach an ECC Decision. The CEPT decision is expected in the first half of 2016.The European Commission is also committed to ensuring that sufficient spectrum is made available under harmonised conditions.It will be interesting to see the UK Government's response, especially in the light of the recent attacks in Paris and the French government's call for wider co-operation between states in the fight against terrorism – where cross border communications could prove vital.The UK's stance to date has been to oppose any mandatory reserving of spectrum for any purpose, including public safety, from the EU, as it believes it should have the right to auction any spectrum as it pleases.James Atkinson EditorLinkedIn |Google + |Email Leave a CommentPlease write code to prove you're humanMore on... LTE GeneralMWC17: Zyxel to debut new LTE and Wi-Fi indoor gatewayHuawei, Vodafone and Qualcomm create LAA ready networkNokia demos live private LTE network over CBRS shared spectrumMore on... Mission critical comms moving to LTETCCA pinpoints key focus areas for LTE-based critical communicationsFinnish Defence Forces to deploy Bittium Tough Mobile smartphonesMore on... TCCATCCA pinpoints key focus areas for LTE-based critical communicationsTCCA drives the standard for critical communicationsPublic safetyTCCA pinpoints key focus areas for LTE-based critical communicationsMotorola launches all-in-one single site TETRA digital radio system Southern Tyrol TETRA network gets a workout at Biathlon World Cup Latest in LTEMWC17: Zyxel to debut new LTE and Wi-Fi indoor gatewayHuawei, Vodafone and Qualcomm create LAA ready networkNokia demos live private LTE network over CBRS shared spectrum


text:
March.4.2015 Dubwise Wednesday series continues. Pictured @kabakapyramid and @yaadcore Image by R. Hohn
Kingston Dub
September.24.2014. Another edition in the Dubwise Wednesday series hosted by Yaadcore featured Rockers Sound Station with Gabre Selassie at the control. Gabre Selassie is the owner and operator of Rockers Sound Station, a sound system dedicated to giving patrons an opportunity to experience authentic roots reggae dub music. It was established in the early 70's
read more


text:
Definition Edit
The Wideband Global SATCOM (WGS) satellite system provides essential communications services to U.S. warfighters, allies, and coalition partners during all levels of conflict short of nuclear war.
Overview Edit
The first satellite was launched in October 2007. Currently, six satellites are on orbit. The seventh and eight satellites are in production and scheduled for launch in 2016 and 2017.
"WGS has evolved to become the replacement to the DSCS constellation. The primary function of the WGS system is to provide high-capacity communications services into the wide variety of large, medium, small, and mobile deployed force terminals. The system enables intertheater and intratheater communications for sustaining bases and dispersed users. U.S. forces will use WGS to extend the ranges of their high-capacity data-transfer networks to other forces across the theater, to the sustaining bases, and to DISN points of presence."[1]
References Edit
- ↑ Joint Publication 6-0, at II-13.


text:
Would you like to save as your currency permanently or for this visit only?
The rooms were clean and the employees were helpful, friendly, and personable. The hotel was not well maintained. We stayed only two nights, but we had no hot water. The pool was inoperable. The tourist attractions listed were not present without a lot of effort. For example, the cave listed was three miles off the road.


text:
A trigger model of apoptosis induced by tumor necrosis factor signaling
Selected articles from the 4th International Conference on Computational Systems Biology (ISB 2010)
The 4th International Conference on Computational Systems Biology (ISB 2010)
The ability of living cells to respond appropriately to apoptosis signals is crucial for the proper development and homeostasis of multicellular organisms. For example, viable cells must be stable enough to appropriately respond to apoptosis signaling so that an irreversible death program is only induced when apoptosis signaling reaches a certain threshold. Previous studies have introduced bistability models in which signaling by caspase-3 activity represents a key regulator of cell fate in response to apoptosis stimuli.
In this study, apoptosis induced by tumor necrosis factor (TNF) signaling is investigated, and a mathematical model without the requirement for bistability is proposed. In this model, rapid degradation of the active forms of caspases -8 and -3 are included, and TNF-signaling is found to induce a pulse of caspase-3 activation and trigger an irreversible death program. This result agrees with experimental observations. The ability of a cell to respond to, or resist, apoptosis stimuli is also discussed. Furthermore, the activation efficiencies of caspases -8 and -3 that are essential to a cell's response to extracellular apoptosis stimuli are defined. Based on the simulations performed, it is observed that activation efficiencies must be sufficiently sensitive to appropriately compromise a cell's resistance and effectiveness in response to apoptosis stimuli.
Our results suggest that bistability may not be a necessary condition for the induction of apoptosis by TNF signaling. Rather, a sharp increase in caspase-3 activity might be sufficient to trigger the induction of an irreversible death program. Accordingly, regulation of caspase activity and degradation of active caspases is essential for a cell's response to apoptosis stimuli.
Apoptosis is a genetically programmed cell death event that is crucial for development, tissue homeostasis, and the immune response of multicellular organisms
There are two pathways known to trigger apoptosis: an intracellular pathway that is initiated when the cell is severely damaged or stressed, and a signaling pathway that is induced when extracellular death ligands are bound by their cognate membrane-associated death receptors
The tumor necrosis factors (TNF) family of proteins is a group of cytokines that can induce apoptosis
Furthermore, TNF-R is associated with pro-caspases through adapter proteins such as Fas-associated protein with death domains (FADD) and TNF-R-associated death domains (TRADD), resulting in the activation of caspase cascades that can irreversibly commit a cell to apoptosis
Many efforts have been made to quantitatively study the process of cell fate determination in relation to the simulation of apoptosis
Bistability may be one reason for the existence of such a threshold
Tawa et al. reported that the rapid degradation of active caspase-3 is dependent on the catalytic activity of caspase-3
This study investigates apoptosis induced by extracellular signaling using a mathematical model that excludes bistability as a prerequistite. The mathematical model used is based on the HCCSL model, yet accounts for the rapid degradation of activated caspases -8 and -3. Moreover, this study is intended to address one aspect of cell fate determination, particularly the predominant signaling mediated by caspase-8 as an initiator and caspase-3 as an executioner, instead of comprehensively modeling apoptosis signal pathways. Despite the restricted nature of this investigation, our model shows fair agreement with experimental results, both qualitatively and quantitatively. As a result, we are able to study the temporal behavior of caspase-3 activity upon stimulation of apoptosis, and explicitly define the activation efficiencies of caspases -8 and -3, which are essential for a cell's response to extracellular apoptosis stimuli.
Model and Methods
Model structure and formulations
Figure 1
A model for TNF signaling-induced apoptosis
A model for TNF signaling-induced apoptosis An illustrated model of apoptosis induced by TNF signaling. TNF signaling induces the formation of membrane-bound death inducing signaling complexes (DISC), which subsequently recruit pro-caspase-8 and activate it by proteolytic cleavage. The active caspase-8 then cleaves various intracellular proteins, including pro-caspase-3, which results in caspase-3 activation and triggering of the cell death program. Caspase-8 cleavage of caspase-3 can occur through two separate pathways, either directly or indirectly, via mitochondria and caspase-9.
In the following mathematical model, not every reaction was modeled. Instead, the time course of initiator protein concentrations (i.e., TNF receptor, caspase-8) and executor concentrations (i.e., caspase-3) of the apoptosis pathway will be focused on. Accordingly, there are five main components in our model, [TNF-R], [Casp8], [Casp3],
Table 1
Rate expressions and parameters
Rate expression
Association of TNF to the receptor TNF-R,
Dissociation of TNF,
Activation of Casp8 through DISC,
Activation of Casp3 directly,
Activation of Casp3 through mitochondria,
[Casp9]0 = 20nM
Synthesis rate
Degradation rate
In the above model, the equation for [TNF-R] is not essential for the apoptosis pathway, and is included only to reproduce the delay of caspase-8 activation that has been observed in experimental data (Fig.
The activation of caspase-8 is a complicated process that requires DISCs. For example, in the case of Fas-signaling induced apoptosis, these processes are composed of many reactions that include the recruitment of FADD, the binding of FADD to Fas receptor, the binding of FLIP or pro-caspase-8 to an adapter protein, and the generation of an intermediate cleavage product Casp82: p41
Figure 2
A simplified model of caspase-8 activation via DISC
A simplified model of caspase-8 activation via DISC In this model, DISC
We assume a first order reaction whereby pro-caspase-3 is cleaved by caspase-8 in accordance with
Molecule synthesis and degradation rates are assumed to be constants. Furthermore, the degradation rates of the active form of the caspases involved are assumed to be 2-3 orders larger than those of their inactive forms.
Parameters used in the present study are listed in Table
Figure 3
Model simulation results for caspase activities
Model simulation results for caspase activities Model simulation results for pro-caspase-8 (A), pro-caspase-3 (B), caspase-8 (C) and caspase-3(D). In (A) and (B), the experimental data (circle dots) are retrieved from
In our simulations, the initial conditions are assumed to be at steady state prior to the onset of stimuli (i.e., [TNF] = 0). Thus, [Casp8] = 33.33nM, [Casp3] = 200.00nM, and
In comparison with the original HCCSL model, two main simplifications have been applied in the current model. First, components of the reactions involved in the formation of DISCs were simplified, and are only represented by the relation between the output flux of activated caspase-8 dimers and input stimuli signals. The second simplification was to represent the amplification pathway mediated by mitochondria as the response of caspase-9 activity to caspase-8 dimer concentration, while having a delay to incorporated to represent the total time required by the intermediate steps. With these simplifications, we are able to reduce the original 35 variable equations to the current model of 5 independent values, and thereby reproduce the same dynamics as the HCCSL model (Fig.
Caspase-3 activity and cell apoptosis rate
Caspase-3 has been well-characterized as an executioner of apoptosis, by cleaving and inactivating PARP and DNA-PK, two enzymes that have been identified to have key roles in the homeostatic maintenance of genomic integrity
In combination, the above observations suggest that the rate of cell apoptosis depends on temporal activation of caspase-3. Therefore, we propose the following formulation to represent the apoptosis rate
and can be measured by flow cytometry. Therefore, the parameters in Eq. 3 can be determined by fitting
Caspase activation efficiency
Here we define the activation efficiencies for caspase-8 and -3, respectively, to measure their ability to generate active forms of caspase-8 and -3 in response to TNF stimuli.
First, we write down the variance equation when [TNF] = 0. Note that when [TNF] = 0, we have
at steady state. Let
Then, using
Biologically, the activation efficiency
Results and Discussion
Caspase-3 activity exhibits pulse increase in response to apoptosis stimuli
The time courses of the concentration of pro-caspases and active caspases were monitored in our simulation for 10 h (Figure
After exposure to apoptosis stimuli, pro-caspase-3 is cleaved to produce caspase-3, which is rapidly degraded. As result, pro-caspase-3 can be consumed even when stimuli are weak. In our model, a straightforward approach obtains the following prediction: If a cell is initially exposed to low levels of TNF signaling for a few hours, the pool of available pro-caspase-3 will be consumed. If high levels of TNF stimulation then subsequently occur, caspase-3 activity will not be as high as it would be in cells that were treated with high levels of TNF stimuli. The prediction is shown by Figure
Figure 4
Model simulation results for a model prediction
Model simulation results for a model prediction The model simulation results obtained for a cell is stimulated with a low apoptosis signal (i.e., 0.1nM FasL) for 10 h, followed by high apoptosis signal (i.e., 2.0nM FasL). (A) Time course of caspase-3 activity. (B). Time course of the apoptosis rate.
A plateau in the apoptosis rate of cells exposed to apoptosis stimuli
The apoptosis rate of cells following exposure to apoptosis stimuli is an important parameter in the study of cell's response to apoptosis signaling. To determine the time dependence of a cell's apoptosis rate, Jurkat cells were treated with 50ng/ml TARIL, and apoptosis was monitored. The experimental methods and results are shown by Figure S1 in Additional file
Additional file 1
Supplimentary Figure 1
Experimental result of Jurkat cells apoptosis induced with TRAIL.
Click here for file
Figure 5
Simulation results for cell apoptosis (
Simulation results for cell apoptosis (
In Figure
We also examined the response of Jurkat cells to different concentrations of TNF stimuli. Simulations show that Jurkat cells were observed to be sensitive to the stimuli, even when ligand concentrations were low (Fig.
Caspase activation efficiencies are important for cell fate determination
Effectiveness and resistance are two important properties of an apoptosis response. To quantitatively analyze these properties, we defined the effective and resistance coefficients of a cell as follows, and demonstrate that they depend on the efficiency of caspase activation.
First, the average half-lifetime (
The effective coefficient (EC) measures the ability of a cell to trigger the death program when the apoptotic initiator signal is strong. Therefore, in the case of FasL-induced apoptosis, we define the EC as the relative half-lifetime that is exhibited in the presence of 100ng/ml FasL (i.e., [TNF] = 2.0nM in the model):
For this definition, a smaller EC represents a more effective response to apoptosis signals.
The resistance coefficient (RC) measures the ability of a cell to resist minor apoptosis signals, and is defined as the change in the relative half-life time when there are minor apoptosis signals as follow:
The negative sign ensures that a positive resistance coefficient will be obtained, and a smaller RC value represents better resistance.
It is important for a cell to simultaneously exhibit good resistance and effectiveness. However, this is not always possible since good effectiveness (i.e., a low EC value) usually implies bad resistance (i.e., a high RC value) (see Figure S2 in Additional file
Additional file 2
Supplimentary Figure 2
Simulation results of the dependence of resistance and effective coefficients to the activation efficiencies of caspase-8 and caspase-3.
Click here for file
To gain insight into how different coefficients in our model affect a cell's response, the dependencies of RC and EC on activation efficiencies were investigated as shown in Figure
Figure 6
Dependence of resistance and effective coefficients on the activation efficiencies
Dependence of resistance and effective coefficients on the activation efficiencies Dependence of resistance and effective coefficients on the activation efficiencies of caspase-8 (A-B) and caspase-3 (C-D). (A-B) The parameters were chosen from 10-5 <
In the present model, according to Eq. 10-11, activation efficiencies are determined by degradation rates and the coefficients
In this paper, a simplified mathematical model of TNF-induced apoptosis was developed based on the Fas-signaling pathway proposed by Hua et al.
In this paper, we also defined the EC and RC of a cell in order to facilitate the quantitative analysis of a cell's response to apoptosis signals. In this study, caspase activations was found to be essential for the effectiveness and resistance of a cell. In addition, we proposed quantitative definitions to represent the activation efficiencies of caspase-8 and caspase-3 in terms of protein degradation rates and model parameters that are related to the activation of apoptosis inhibitors. Our results suggest that caspase activation efficiencies can be regulated by inhibitors such as X-linked inhibitor of apoptosis protein (XIAP), cFLIP and Bcl-2 family members, which have been shown to be essential for the apoptosis pathway. Additional studies will be needed to further investigate the regulation of apoptosis inhibitors in the apoptosis pathway.
Competing interests
The authors declare that they have no competing interests.
Authors contributions
JL designed the studies, analyzed the simulation data, and wrote the paper. CG and JZ developed the model. CG performed the numerical simulations. YC performed the experiment. All authors have read and approved the final manuscript.
This work was supported by the grants from the National Key Project for Basic Research of China(973, 2011CB910103) and the National Natural Science Foundation of China(30771057 and 10971113).
This article has been published as part of
Apoptosis by death factor
Bistability analyses of a caspase activation model for receptor-induced apoptosis
The biochemistry of apoptosis
Tumor necrosis factor. New insights into the molecular mechanisms of its multiple actions
The molecular action of tumor necrosis factor-
Two CD95 (APO-1/Fas) signaling pathways
Review: Nuclear events in apoptosis
Apopain/CPP32 cleaves proteins that are essential for cellular repair: A fundamental principle of apoptotic death
Bistability in apoptosis: Roles of Bax, Bcl-2, and mitochondrial permeability transition pores
Mathematical modeling reveals threshold mechanism in CD95-induced apoptosis
A mathematical model of caspase function in apoptosis
Effects of Bcl-2 levels on Fas signaling-induced caspase-3 activation: molecular genetic tests of computational model predictions
Mathematical modeling identifies inhibitors of apoptosis as mediators of positive feedback and bistability
Simple computational models of typeI/typeII cells in Fas signaling-induced apoptosis
Mathematical modeling of the regulation of caspase-3 activation and degradation
Early stages of p53-induced apoptosis are reversible
Temporal relationships between ceramide production, caspase activation and mitochondrial dysfunction in cell lines with varying sensitivity to anti-Fas-induced apoptosis
Catalytic activity of caspase-3 is required for its degradation: stabilization of the active complex by synthetic inhibitors
Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE
DNA repair is activated in early stages of p53-induced apoptosis
Common regulation of apoptosis signaling induced by CD95 and the DNA-damaging stimuli etoposide and
Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family
Signaling events triggered by Tumor Necrosis Factor-Related Apoptosis-inducing Ligand (TRAIL): Caspase-8 is required for TRAIL-induced apoptosis
Identification and characterization of a new member of the TNF family that induces apoptosis
Caspase-dependent initiation of apoptosis and necrosis by the Fas receptor in lymphoid cells: onset of necrosis is associated with delay ceremide increase
X-linked IAP is a direct inhibitor of cell-death proteases
Structural basis for the inhibition for caspase-3 by XIAP
IAP proteins: Blocking the road to death's door
Regulation of the Apaf-1/caspase-9 apoptosome by caspase-3 and XIAP
Inhibition of death receptor signals by cellular FLIP
The CD95 receptor: apoptosis revisited


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Monday, January 18, 2016
SpaceX Successfully Launches Jason-3 Mission, But Sees Sea Landing Failure
Hawthorne-based SpaceX, the commercial rocket launch company led by Elon Musk, saw a successful launch on Sunday of the Jason-3 mission for the National Oceanic and Atmospheric Administration (NOAA), however, the company's attempt to land its reusable rocket on a floating "droneship" was less successful, when that rocket tipped over after landing--and exploded in rather spectacular fashion. According to Musk, the Falcon successfully landed on its floating drone ship, but tipped over because one of the four legs that support the rocket did not latch. Musk speculated the failure may have been due to ice buildup from condensation from heavy fog during liftoff. SpaceX had successfully landed the Falcon--on land--but has been attempting to land the rocket on a floating platform in the ocean.


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Recently, as I was reading through several personal finance/mortgage books, I realized that I hadn't previously included in the My Money Blog Account Hierarchy an important factor in many people's account prioritization decision-making process.
What is this component/factor? – It is how home mortgage payments fits in to the overall picture.
In order to keep the entire account hierarchy in one location, you can view the completed account prioritization list at the link shown below.
My Money Blog – Account Hierarchy
Let me know if you have any questions!
Keep on learning!
To receive updates on topics such as this one as soon as they are published, click on the link below to subscribe to My Money Blog:


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Biological Sciences
Biological Sciences
The hand-on laboratory experience, making discoveries through research and gaining a global perspective in a constantly evolving field are some of the hallmarks of the biological sciences at Union
(USA Today College Guide 2017)
Compared to colleges of similar size, the range of courses offered at Union is exceptional – cell and molecular biology, neurobiology, bioengineering, plant and animal organismal biology, environmental biology, developmental biology, and ecology and evolutionary biology, to name a few. Consequently, our students are able to explore their interests and aptitudes in many different areas.
Our common curriculum courses range from "Understanding Cancer" to "Food and Health in the 21st Century" to a field course combining supervised observation and service learning experiences in various health care settings with on-campus seminars. Biology is central to numerous interdisciplinary programs: biochemistry, bioengineering, environmental science and policy, and neuroscience.
Research facilities
Union's equipment and research laboratories are first-rate. Many biology faculty research labs are housed in the Peter Irving Wold Center, Bioengineering Center or Center for Neuroscience. Our undergraduates have access to such advanced instruments as a laser confocal microscope, video-microscopy workstations with digital image processing and microinjection capabilities, PCR workstations and much more.
"I learned so much about dragonflies' movement during my research with Professor Robert Olberg. I learned to micro-dissect, put in electrodes to stimulate the specific neurons and – on a lighter note – the art of catching these speedy creatures."
- Sriya Bhumi
An NSF Major Research Instrumentation Grant has enabled the College to acquire a continuous flow Delta V Plus isotope ratio mass spectrometer and supplemental components to support interdisciplinary research and undergraduate student research training.
Special learning opportunities
Many students carry out independent research under direct faculty supervision, which leads also to participation in Union's annual Steinmetz Research Symposium and national scientific meetings, as well as to publication as co-authors in scientific and professional journals.
Our accomplished faculty have received research grants from the National Science Foundation, National Institutes of Health, Air Force Office of Scientific Research, Howard Hughes Medical Institute and other prestigious foundations.
In addition, Union's proximity to the Adirondacks, Albany Pine Bush, Mohawk and Hudson rivers, and many natural lakes offers innumerable field research opportunities.
As a biological sciences major, you will find that your classroom, laboratory and close working relationship with our faculty will provide a solid foundation for success in graduate and professional schools and in any number of careers, including medicine, biotechnology, veterinary science, dentistry, research science, environmental conservation and public policy.


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Mazda CX-9 Problems
RepairPal has identified the most common problems with the Mazda CX-9 based on complaints from actual vehicle owners. We'll tell you what the problem is and what it'll take to fix it.
Various electrical issues may develop related to the body control module (BCM). There have been reports of water damage to the BCM caused by clogged or damaged sunroof drains. It is recommend to periodically inspect the sun roof drain for debris and clean as necessary.
The Mazda CX-9 is known to have issues with hard shifts and transmission slippage on models equipped with the six speed automatic transmission. When the transmission gets warm, the issues is most noticeable as a hesitation to shift, followed by jerking or jolting into the next gear. These issues are not typically observed in combination with the check engine light.
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A chirping or squeaking noise may be noted from the front of the vehicle when traversing bumps at low speeds. Our technicians tell us this type of noise is generally caused by the front strut mounts which will require replacement.


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Title: Anything But Ordinary
Author: Star
Rating: PG-13
Dedication: Vic, without you I'd never have seen Taz and Charlie to be such a great combination. She's all wrong for Fulton, Limpet was wrong! Then again, Taz has really come out of her shell since then!
Feedback: Hit me! Go on! I love it!
Disclaimer: Disney et all still own 'em. *sigh* Taz, aka Purple Girl belongs to me and Maya belongs to Victory Thru Tears, but I think everyone knows that by now!
Distribution: Our site, Queertet which can be found at http://www.queertet.com/ Anyone else: Want. Ask. Take. Have. We'd be beyond thrilled. By the way, we also have a Ducks List, to join, just go to http://groups.yahoo.com/group/MightyDucksMovies/
Summary: In Snow, Adam said to Charlie about Taz, "In a parallel universe, she's your wife." Wanna take a look at that parallel universe?
Notes: This is sort of set in Victory's 'Something Quite Special' universe. Basically, she wrote an amazing story and I'm plagiarising it. *winks at Vic* Sorry, babe. Essentially, Adam and Maya are dating, Charlie's still with Linda, but for how long?Part 1 ~ Piffling Gremlins
Charlie's POV
As I walk with Maya and Adam I have to wonder what the hell I'm doing here. I could be spending the day with Linda.
Ah-ha! That's why I'm here.
I had only two very unappealing options. Go with Adam and Maya to the mall and catch a movie, or spend time with Linda.
It's not that I don't like her. I did at some point, but recently she's driving me up the wall, making snide comments about the rest of the Ducks, and being so pro-this and anti-that that we never get time to have a conversation. It's getting to the point where I just can't be bothered.
"Maybellina-marna!" I hear a distinctly Irish voice yell loudly.
"Tazmania!" Maya responds equally loudly.
"Oh god, it's a female Averman." Adam mutters.
I note the source of the first voice, a tiny girl with bright purple hair is standing on a bench waving madly. She's even smaller than Maya. I check Adam's reaction, he look surprised too.
Maya dashes towards the purple haired girl and embraces her tightly. The purple girl is gabbling at the top of her lungs.
As Adam and I approach I hear Maya say, "English, Taz. Speak English."
"Sorry!" She grins back. I notice that her eyes are purple too. Contacts, surely. No-one has purple eyes. "I'm just so happy to see you."
Adam clears his throat, reminding Maya that the two of us still exist.
"Oooh!" Purple Girl's eyes light up. "This must be Boyfriend! Or Boyfriends. Which one belongs to you… or is this a very disturbing ménage a trois?"
I have to laugh. This girl is insane.
"Taz, honey." Maya loops an arm around her. "How much soda have you had?"
"Just three cans. And some of those yummy sherbet dabs." She answers promptly.
Maya sighs. "Great. Sugar-highed." She says with a fixed grin. "Anyway, this," she gestures to Adam. "Is my boyfriend, Adam. The other guy is Charlie, his best friend. Guys, this is my friend, Taz. She's the one who drew that picture I have on my wall." She adds to Adam. Having never been in Maya's room I have no idea what she's talking about.
Taz bounds over to me and shakes my hand vigorously. "Nice to meet you, Charles."
"Charlie." I correct. I hate it when people call me Charles.
"That's what I said, Charles." She grins big. I wonder if anyone would mind if I killed her.
"What's Taz short for?" I ask her.
"Tazmanian Devil." She answers. I've only known her a few minutes, but I wouldn't be surprised if that's the truth.
"Taryn Anne McDonald." Maya supplies.
Taz looks mildly annoyed. "Hey, Maya, best friend here! I'm your oldest and bestest friend in the world… except for those ten or twenty people who've known you longer and better."
Maya grins back at her. "If you want to torment Charlie, that's fine, but I have to give him a little ammunition so he can defend himself."
I give Adam and evil look, and wonder idly if this is some form of payback for being nasty to him when he made Varsity.
Taz turns her attention to him, and he looks alarmed. She interrogates him sternly, making sure he's good enough for Maya for a few minutes, until Maya very firmly tells her to hush.
"So what movie are we seeing?" Maya asks a subdued Taz.
Taz shrugs.
"You didn't think to pick up a listing?"
"Why bother? We can just go to the cinema and find out what's on there." Taz replies, perking up once more. "I vote for Ice Age."
"Taz, I saw that last week with Adam." Maya tells her as we all start to walk.
"You didn't tell me that there would be a lunatic here." I say to Adam in a low voice.
He looks slightly guilty. "I knew that Maya was meeting an old friend, I didn't realise that her friend was on day release."
"I heard that!" Taz says over her shoulder, she doesn't look even remotely offended. In fact she looks amused. Linda would never see the funny side of that.
"Sorry." I say.
She shrugs indifferently. "I'll take it as a compliment."
She can't be from this planet. Adam and I have just insulted a girl we've known only five minutes, and she's pleased?
Once we arrive at the cinema a heated debate breaks out. Taz is firmly ensconced in the Ice Age corner, while Adam and Maya are desperate to see Panic Room. I haven't seen either. Taz speaks up saying that she'll see Ice Age by herself if the three of us want to check out the other one.
Now this puts me in a bind. Do I want to be third wheel with the happy couple or do I want to see a kids flick with a lunatic? Who knows what she'll get up to.
"I'm about to buy my ticket." Taz threatens. "Last chance to change your minds. You know you want to see it!"
"I'll go with you." I say. I'm not sure why. Maybe it's because she's so tiny and I don't like the idea of her going anywhere by herself.
She gives me a thousand watt smile, it lights up her whole face. She's a very pretty girl.
"I'll get the tickets." She decides. "You can get the munchies. I'm allergic to touching popcorn, so unless you're willing to feed it to me, that's out. And don't get me soda, it makes me hyper. Juice is good, but I like it watered down. 80% ice, 15% water and 5% juice."
Suddenly I regret my decision, but it's too late now because she's bounding over to the vendor.
Maya smiles and touches my arm. "Get her Milk Duds, any type of juice is fine as long as there's plenty of ice. And don't worry, she'll quiet down once the film starts, you won't even know she's there. And even if she doesn't, just tell her to hush and she will."
Why do I feel like I've been left babysitting a complete terror, and the smug mother is giving me last minute instructions before making a break for peace and quiet?
I glare at her and my supposed best friend. "Any other rules or advice? Does she turn into a monster if you feed her after midnight?" I ask sarcastically. Lunatic Taz might be, but she's neither a child or my responsibility.
The look on Maya's face lets me know that, for the first time in her life, Taz has made a quiet entrance.
"Now you've done it." Maya mutters.
I whirl round, all set to make yet another hasty apology. Instead of the hurt expression I'm expecting, Taz's face is showing pure joy.
"You're a Gremlins fan too?" She asks excitedly. I am, it's my favourite movie to watch at Christmas." She then launches into a quick skit highlighting the funniest moments of the movie. You wouldn't think this tiny perky Irish girl could make Gremlin sounds but she can. She even makes her ears wiggle for the Snow White part of it.
I'm laughing so hard that I barely notice Adam and Maya making their exits.
People are staring at Taz, but she doesn't care. Linda hates calling attention to herself when she's having fun. Maybe it's because fun is a rare event for Linda and she's somewhat concerned she's not doing it right.
Taz has no such qualms, and continues her manic babble as we queue for drinks (juice, lots of ice – no soda), and Milk Duds (I'm not hand feeding her popcorn, although part of me really wants to know how you can be allergic to touching it, but not eating it and what exactly the reaction would be if she touched it).
"Come on, Gremlin." I take her elbow and lead her towards the screen showing Ice Age. Once we cross the threshold she shuts up immediately. You'd have thought that when someone is babbling as much as her they'd need time to wind down. She's a highly intriguing girl, if somewhat irritating.
"Don't let me fall over." She whispers to me, taking my arm to steady herself.
I give her a bemused look. What does she mean?
"Those lines of lights." She points to the subtle strip lights on the floor. "They make me lose my balance. I really want some for my house though."
I grin and hold on to her.
We find our seats and only have to climb over three people to reach them, which is my definition of a very easy time.
When the movie starts Taz becomes completely immersed in the story, I myself am not entirely uninvolved, but I find myself sneaking glances at her at regular intervals. Her eyes never leave the screen, or if they do, I don't see.
She's completely oblivious to me – the rest of the world even. I'm stunned to see her get sniffly at the emotional part of the film.
Linda would never do that. Then again, Linda would never watch Ice Age, because 'filmmakers today seem to change history to suit themselves and their budgets. It's morally wrong to fill the heads of children with such piffle'. That's a direct quote. And yes, she really did use the word 'piffle'.
When the film ends and the lights come on Taz looks visibly startled, as if she couldn't quite remember how she got here.
"You ok, Gremlin?" I ask her.
She nods and gets up. I have to offer my arm again, a Taz is obviously not designed for staying still for longer than ten minutes and she's going to be like a coiled spring when she gets outside. I don't know how I know this, I just do.


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Bankruptcy Law
Bankruptcy Law Questions? Ask a Bankruptcy Lawyer.
Clarification. I thought the judgment (50K) from an adversary proceeding in bankruptcy court was enforceable after bankruptcy as a debt. ($0 assets left) this debt could be used to garnish wages etc...
But what your saying is, the judgment only applies to bankruptcy assets?
Ok. That sound right. (the 50K is nonchargeable) This protects the bank if they get less then the liens on the property. But I'm a little confused on the fact that they could enforce the judgment beyond the value of the lien ('then the additional proceeds could be seized by the sheriff to satisfy the bank's judgment'), since the 50k is basically part of the 500k owed?


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September 26, 1983. Soviet early-warning systems register five blips heading for its airspace, but are they American missiles or something more innocent? For a few brief moments the fate of the world rests in the hands of a humble Soviet officer called Stanislav Petrov.
A peculiar mix of documentary and reconstruction that never quite gels, this is a sincere tribute to Soviet colonel Stanislav Petrov, whose mistrust of a computer prevented nuclear devastation in September 1983. Footage of his 2006 US tour is surreal.
A gripping and unheralded story that doesn't quite get the telling it deserves.


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The Chicago Times-Herald published a significant share of the early prose fiction and verse of L. Frank Baum. The newspaper was Baum's most consistent market in the middle 1890s.
Early Baum stories that appeared in the Times-Herald include:
- "They Played a New Hamlet" (28 April 1895)
- "Who Called 'Perry'?" (19 January 1896)
- "Yesterday at the Exposition" (2 February 1896).
The paper also printed poems by Baum, including:
- "La Reine est Mort — Vive La Reine" (23 June 1895)
- "Farmer Benson on the Motocycle" (4 August 1895)
- "Two Pictures" (5 May 1896)
- "The Latest in Magic" (31 May 1896).
"Two Pictures" is a sports poem, while "The Latest in Magic" is about the discovery of X-rays in 1895.
The Times-Herald was the result of an 1895 combination of two earlier papers, the Chicago Times and the Herald.[1] In turn, the Times-Herald merged with other papers in the evolving Chicago newspaper market; a 1901 combination with the Chicago Record produced the Chicago Record-Herald. That paper published Baum's "Fairy Tales on Stage" in 1905.
The Times-Herald also printed the "Strange Tale of Nursery Folk" (1901), a story of disputed authorship.
In 1914 the Record-Herald endured another amalgamation to yield the Chicago Herald Examiner.
- ↑ W. W. Denslow once worked, briefly, for the Herald. At one time the managing editor of the Herald was Leigh Reilly, brother of Baum's publisher Frank Kennicott Reilly.


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Rush, Rush!
>> Wednesday, December 18, 2013
Because of the Christmas rush, life got so hectic around here. Aside from doing the gift-shopping, I am also busy with production of commissioned orders. As a one-woman team, this peak season can be very tiring but nah, I am not complaining. Like what I always say, I am grateful for the chance to do what I enjoy and earn from it.
I just wish that I have extra hands so I can so many things at a time but yes, that's a wishful thinking. Some relative and friends (and even my husband) suggested that I get some help but creating these commissioned orders for me is a personal task. I don't have the courage to delegate the work to others for now. Some people think that I should think of expanding the business, accept more orders, but that means more concerns, challenges and stress. I don't think I can deal with a lot of changes and challenges for now. As of the moment, I just want to enjoy what I do and it makes me happy to know that others like what I create for them.


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Product Details
|Outer material
|95% viscose, 5% elastane
|Band merch, Bands
|Heavy Metal
|Available since
|Product code
- with front print
- boat neck
- 1/2 sleeve
Volbeat don't just sound great on a studio album, but also live on stage. With their mixture of Country, Blues, Punk Rock, Rock'N'Roll and Metal they rock the biggest stages worldwide. This black-grey "Old Letters" girls shirt features Volbeat's characteristic Denmark Skull, and the Volbeat lettering.
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Just received my Volbeat shirt I ordered a few days ago and it's awesome.... I even managed to score the right size! (If anybody finds this helpful regarding sizes...I'm size 46 EU / 18 UK, and I ordered XL shirt and it fits perfectly.)
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Director :
Music Director :
Star Cast :
Lyricist :
Release Date : 1977
Description :
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Google Classroom
A Virtual Training Opportunity
What is Google Classroom?
Getting Started
Google Classroom is very user friendly and easy to set up. This video will show you how to set up your Classroom, customize the look of Classroom, and create assignments/announcements.
Thanks to Amy Mayer for creating this presentation.
Your First Assignment
When logging in to your account for the first time, be sure to select Teacher, not Student. As a teacher, you can join or create classes. As a student, you can only join classes.
Having trouble creating your first class? If you see an error message that asks you to contact your administrator, submit a RequestIT ticket.
See how Google Classroom looks from a student's perspective by logging in to my class and completing an assignment.


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Pleasant buying experienceWritten by hancockbs on 12/27/11 04:56:18 AM PST Go back to Sales reviews
Recommend this dealer? Yes Purchased a vehicle from this dealer? Yes
The sales experience was good. I feel like I got a fair price for my trade and the new CX9 I bought. There was little pressure from the sales staff, it was a low threat environment with little haggling needed. The service experience is different. The service staff is not very friendly and insinuated that any of my problems with the new vehicle must be my fault and can't be real. I will try them once more to finish work on a problem that they have done little to resolve, but will probably go elsewhere for my service in the future.


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This products ships to USA only.
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|Follow Us
Meet Joburg organises and hosts events where single people can interact and socialise while taking full advantage of living in this awesome city.
Meet Joburg is NOT a dating agency or a matchmaking service. No internet dating. No blind dating. No pressure. Just like-minded, single people doing awesome things in and around Jozi.
Events are structured around four pillars:
In order to cater to everyone's taste and preference we have several membership and event options.
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On the 5th July 2010 we opened the fourth SimplyFixIt repair centre at Forrest Road, in the heart of the old town. Just at the end of George IV bridge, beside the Greyfriar's Bobby statue. SimplyFixIt Forrest Road is in a great location for those who work in town. You can pop into the shop to or from work for a quick chat with one of our technicians. Or just drop your broken / damaged laptop or iPhone on the way to work and collect it that evening or the next morning. We can repair cracked screens, water damaged iPhones and laptops, with a fast turn around service right in the city centre of Edinburgh
Address.1 Forrest Road
United Kingdom
0131 549 8820 (Option 4)
Opening Times.
- Monday: 09:00 – 19:00
- Tuesday: 09:00 – 19:00
- Wednesday: 09:00 – 19:00
- Thursday: 09:00 – 19:00
- Friday: 09:00 – 19:00
- Saturday: 09:00 – 19:00
- Sunday: 09:00 – 19:00
View larger map
About the area:
SimplyFixIt Forrest Road featured our first dedicated Apple iPhone & iPad repair centre. It wasn't long before SimplyFixIt Forrest Road staff gained Apple Certified Mac Technician status making us the only computer repair store in Edinburgh to have both Certified Microsoft Technicians and Certified Apple Technicians working under the same roof.
The shop itself sits on the border of 2 roads, Forrest Road and Greyfriar's Place. It occupies the spot where Traill's Temperance Coffee House (The Eating Place). This is famous for being the cafe where Greyfriar's Bobby was fed every day while he tended his master's grave. You can read a lot more about Greyfriar's Bobby on our dedicated Greyfriar's Bobby webpage


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Crystal Luthor Photographer
KelseyRoseModel Female Milwaukee, Wisconsin, US
My MM URL: http://www.modelmayhem.com/KelseyKoller
Mayhem # 2304222
About MeI'm an incoming college student. I really enjoy fashion and shopping for different things to mix it up. My style ranges, from stores like forever21, Express, TJ Maxx, to Macy's. I look for different trend ideas through magazines websites and friends, while creating my own. Getting ready in the morning is something I enjoy doing. Experimenting with different hairstyles and make-up techniques, helps individualize who I am. I like to People have told me to look into modeling websites when they looked at my senior pictures. After much thought, I decided this would be a good opportunity for me. I am for trying different types of modeling to gain experience. I am trying my hardest I can to create a modeling career. If you would like to contact me, you can email me. Thanks!
Have you worked with KelseyRose? Add Credits for KelseyRose! >>
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Meghan Peters Hair Stylist
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text: This article is a disambiguation page for Samagui The following is a list of links to pages that might share the same title. Please follow one of the disambiguation links below or search to find the page you were looking for if it is not listed. If an internal link led you here, you may wish to change the link to point directly to the intended article. Samagui could refer to : Samagui (Character), the hunter. Samagui (Spell), the Human Subordination Magic Spell. Retrieved from "http://fairytail.wikia.com/wiki/Samagui?oldid=935098" Ad blocker interference detected! Wikia is a free-to-use site that makes money from advertising. We have a modified experience for viewers using ad blockers Wikia is not accessible if you've made further modifications. Remove the custom ad blocker rule(s) and the page will load as expected. Categories: Disambiguations Add category Cancel Save


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Battle Bills are Bullet Bills that do more than just be launched and hope to hit you. These guys fight you and hope to hit you. They look like Bullet Bills with red eyes (green on the red variation)
They are great fighters indeed. They will follow you if they see you. However, they cannot see you if you go through a hidden tunnel, which will make them be confused for a while and then go away. If you can make them hit a wall, then they will be stunned a bit. It takes 3 wall hits or jumps on the head to destroy these. If one runs into a block, they will destroy it, but take a hit in the process. If they hit a ? block, then they will make the item fall below and the ? block will be destroyed and the Battle Bill will take a hit. They are rarely found shot out of Battle Bill Blasters, as they normally fly in the air.
Normal ones will just follow you. However, there are others.
Red ones will use flamethrowers.
Light blue ones breath ice.
Yellow ones make branching lightning bolts.
Dark blue ones toss boomerangs.
Green ones whip with spiky vines.
Purple ones spit blobs of poison that splatter.
White ones toss bombs.
Battle Bill Blasters
These are rare, as stated above. The only levels they are in (by the way Battle Bills are only in More New Super Mario Bros) are level 7-3, level 8-6, level 8-10 (mid boss castle), world 20/all levels Blasted Bills, getting hit by one on the map of world 6, and have a cameo in the start of the game. Belive it or not, it is possible to destroy these. You must jump on it 10 times to do so, though. Some Battle Bill Blasters will target you, some willl be like regular Bullet Bill Blasters, and some will have wings or wheels and chase you, or they may have wings and be able to fly. Some are operated by Monty Moles, though. If you take out Monty, you can actually control the Blaster! This is a tactic in the minigame Blasted Bills.


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We're now on the Jewish Museum of Florida-FIU exhibition schedule…..
…and we love how they present the show. Cannot wait for this run!
"Jews have had an extensive contribution to comics. But the focus has been mostly on men and superheroes. How did women contribute to the history of comics, and in particular, to autobiographical comics, a genre they helped birth? What is particularly Jewish and female about how they did it? And, why unveil parts of yourself and your life in comics? These are the questions posed to 18 artists, whose writings and drawings depict their own pain, laughter, shame, triumphs and self-doubts in a way that taps a collective nerve."


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Archive: (3 Stories)
Obama: Figure out how to satisfy US water needs
02/15/2014 7:52amPresident Barack Obama drew a link between climate change and California's drought, and said the U.S. must do a better job of figuring out how to make sure everyone's water needs are satisfied.
Scholars: Roosevelt the best first lady, Obama 5th
02/15/2014 2:08pmA survey of academics has found that Eleanor Roosevelt was the nation's best first lady. Michelle Obama ranks fifth.
Obama signs debt ceiling measure into law
02/15/2014 7:19pmPresident Barack Obama on Saturday signed separate measures into law to lift the federal debt limit and restore benefits that had been cut for younger military retirees.


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Posted by DIGITAL - VERIFIED EMPLOYER VERIFIED13 Feb 9:32 amIkeja, Lagos
Responsible for helping individuals and companies individuals examine their immediate and long-term financial situations to appropriate use their savings, income, and make investments. Analyze financial situations to determine risk, reward, and opportunity.
Primary responsibilities
• Prepares financial and business related analysis and research.
• Draft consolidated forecasts and budgets and analyzes trends in revenue, expense, capital expenditures and other related areas.
• Develop financial review templates and meetings.
• Devise debt liquidation plans that include payoff priorities and timelines.
• Explain to clients the details of financial assistance available to college and university students, such as loans, grants, and scholarships.
• Implement financial planning recommendations.
• Determine clients' current income, expenses, insurance coverage, tax status, financial objectives, risk tolerance, and other information needed to develop a financial plan.
• Monitor market trends.
• Make recommendations in areas such as areas as cash management, insurance coverage, and investment planning.
• Sell financial products.
• Review clients' accounts and plans regularly to determine life changes that would affect financial strategy.
• Collect information from students to determine their eligibility for specific financial aid programs.
• Convene with clients' other advisors, including attorneys, accountants, trust officers, and investment bankers, to fully understand clients' financial goals and circumstances.
• Open accounts for clients and disburse funds according to financial goals.
Stay safe!
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Our Pretties
I like classical and popular music.
I like Classical literature, Master and Margarita, War and Peace
I love roses.
I enjoy summer.
I love comedies with Jim Kerry like Ace Ventura: Pet Detective.
I like to wear white and black, red, blue clothes, it depends on my mood and weather!
I like walks, meeting friends, design.
I would love to be happy with my beloved one!
I like our Ukrainian and Italian dishes.
I love cooking pasta, lasagna
Yes this is my hobby.


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You've already got 5 items in your shopping cart, so there's no room to reserve another one. If you'd like, you can take something out of your cart to make room for this one.
Play Trailer
Crooked Arrows
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Plot Summary
Plot: Crooked Arrows centers on Coach Joe Logan, who reluctantly leads a Native American high school team on their unlikely journey to the state lacrosse championship game against their prep school rivals. Along the way, Joe and the team rediscover their connection to the spiritual tradition of the ancient sport of lacrosse. Set in the diverse worlds of modern Native American culture and prep school lacrosse.
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How to buy in-person at the Box
1. Go to Box:
2. Tap RENT & BUY GAMES
3. Tap FOR SALE
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Man, September is sure becoming crowded in terms of genre programming at theatres. Make sure you stockpile your popcorn money because moving up from its original October release is the Sorority Row remake.
The new release date for the flick is September 11th, putting it directly up against Whiteout, and then Jennifer's Body and Pandorum the very next week! Nifty!
Look for more on the film soon!
Sorority Row – Trailer
Uploaded by dreadcentral
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Play pranks that lead to death in the Dread Central forums!


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Thanks to all Grass Valley residents
December 26, 2012
On behalf of the Committee for Yes on Measure N and all of the folks who worked hard to educate and encourage a Yes on N vote and to those who did vote yes, a big thank you.
By passing Measure N significant improvements will be made in public safety via our police, fire and road departments. Voters' decisions to invest in our community will help us maintain our quality of life in this wonderful community. Well done!
Ed Thomas
Grass Valley
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- UPDATE: 1 charged with murder in Penn Valley death


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Find Hostels all over the World
Centre International de Sejour Maurice Ravel, HOSTEL in Paris France.
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The Maurice Ravel International Center gives you a warm welcome in a modern and pleasant setting.
Chill out in our designated relaxation area where you can e


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The apex court's order would be a major setback for transparency and democracy in India and would dilute the RTI Act more seriously
The Supreme Court has recently given an order imposing costs of Rs1 lakh on the Karnataka Information Commissioner for what it calls a frivolous litigation. This has serious implications on the Right to Information (RTI), which may be more damaging than the amendments that were stalled by citizens remonstrating.
The facts are as follows: The Commission had approached the Supreme Court against an order by the Karnataka High Court quashing its order. This case has far-reaching implications for the citizen's fundamental right which has been codified in the RTI Act. An applicant had filed for information from the Karnataka High Court under the RTI Act. The Public Information Officer (PIO) of the court had refused the information on the grounds that the citizen must seek information under the Karnataka High Court rules.
As per the RTI Act, refusal of information can only be under the provisions of Section 8 and 9. The State Information Commission did not agree with the PIO and asked him to provide the information under the RTI Act. The Karnataka High Court had named the applicant as a respondent in the case and quashed the Commission's order.
The Commission sought to contest this order before the Supreme Court and the petition was filed by an Information Commissioner. The court has taken umbrage to the petition being filed by an Information Commissioner and has said that the Commission and Commissioner have no locus and are wasting public money by challenging the order.
I believe that a very important point of law was involved, which has not been addressed by either the high court or the Supreme Court. Section 22 of the RTI Act expressly provides that the provisions of the RTI Act shall have effect notwithstanding anything inconsistent therewith contained in the Official Secrets Act, 1923, and any other law for the time being in force or in any instrument having effect by virtue of any law other than the RTI Act.
In other words, where there is any inconsistency in a law as regards furnishing of information, such law shall be superseded by the RTI Act. Insertion of a non-obstante clause in Section 22 of the RTI Act was a conscious choice of the Parliament to safeguard the citizens' fundamental right to information from convoluted interpretations of other laws and rules adopted by public authorities to deny information.
Section 22 of the RTI Act simplifies the process of implementing the right to information both for citizens as well as the PIO; citizens may seek to enforce their fundamental right to information by simply invoking the provisions of the RTI Act.
By this order the Supreme Court without addressing the provision of Section 22 has sanctified and legitimized denial of information under Right to Information, if any public authority claims there are any rules for giving information. This could have the effect to nullifying the impact and effect of the RTI Act in a serious way. Without Section 22, the Act will become fairly ineffective and public authorities will be able to block many RTI users.
I believe Information Commissions have a legitimate duty to pursue the provisions of the RTI Act and champion them in the spirit of the Act. Very few Commissioners do this, and the Supreme Court's strictures for a legitimate exercise by a statutory authority are unfortunate. This would discourage Commissions from pursuing their duties. Logically, anyone who is a respondent or a petitioner has locus in a case.
I must point out that there is confusion amongst the courts on the matter of who should be the respondents when a RTI decision of the Information Commission is challenged in a writ. Karnataka and Bombay High Courts call the Commission as a respondent in many cases, and the Andhra High Court issues notice to AP State Information Commissioner and AP State Information Commission as a respondent. The Gujarat High Court named RN Das, Chief Information Commissioner as a respondent in WP 5178/2008, while the Delhi High Court refuses to accept the Information Commission as a respondent since last two years.
The only unexplained exception was in WP 3318/2012 when Shailesh Gandhi (myself), was named as respondent by the court, for discharging legitimate duties as an Information Commissioner. In these circumstances, the Karnataka Commission could not have had clarity on whether it could file a challenge to the ruling. If a citizen can file a PIL, is it so objectionable if an Information Commission challenges a major dilution to the RTI Act?
We recognize the Supreme Court's jurisdiction in interpreting the law. In this case neither the high court nor the Supreme Court has dealt with the provision of Section 22 of the RTI Act, but appear to legitimize denial of information by all public authorities on the ground that citizens must apply for information under various rules. These have their different provisions and absence of independent appellate structures and penalty clauses.
Apart from this, the Supreme Court has issued a public reprimand to a statutory authority, without compelling reasons. Respect for the rule of law requires respect for the orders of various statutory authorities. This order would be a major setback for transparency and democracy in India. This will dilute the RTI Act more seriously than the removal of file notings from the ambit of RTI. If citizens are not vigilant, RTI will get constricted by such orders. RTI users must become aware of the damaging consequences of this order and discuss its implications.
(Shailesh Gandhi served as Central Information Commissioner under the RTI Act, 2005, during 18 September 2008 to 6 July 2012. He is a graduate in Civil Engineering from IIT-Bombay. Before becoming a full time RTI activist in 2003, he sold his packaging business, Clear Plastics. In 2008, he was conferred the Nani Palkhivala Memorial Award for civil liberties.)
The PIO sent a complaint to the Registrar of Cooperative Societies, against which allegations of corruption of about Rs39 crore were made. The CIC then asked the PIO to provide letters and file notings of the process followed to take the decision. This is the 32nd in a series of important judgements given by former Central Information Commissioner Shailesh Gandhi that can be used or quoted in an RTI application
Questioning the rational of sending a complaint to the body against which the allegations are made, the Central Information Commission (CIC) directed the Public Information Officer (PIO) to provide the letters and notings which evidence the process of deciding to send this case to the body. While giving this important judgement, Shailesh Gandhi, former Central Information Commissioner said it appears a little bizarre and difficult to understand what purpose would be served by this.
"The Commission directs Amitabh Joshi, the PIO of the Director of Vigilance, to provide the letters and notings which evidence the process of deciding to send this case to the Registrar of Cooperative Societies (RCS)," the CIC said in its order issued on 13 July 2009.
Delhi resident Rajinder Kumar Kaushik, on 9 May 2008, filed a complaint about corruption and embezzlement to the tune of Rs39 crore alleging that officers of the Registrar of Cooperative Societies were involved with the Central Bureau of Investigation (CBI). He sought the status and progress report of the following documents:
i) Letter No.DLI/ACB/Complaints/CA-2865/06/8123 dated 08/06/20007 sent to the Director (Vigilance) w.e.f 13/11/2006 to till date
ii) The names and designations of the officials who were entrusted/assigned to take action or investigate.
iii) The names with the addresses of the persons who were summoned to appear or record their statement and/or examined in the process of investigation.
iv) As these officials (who were supposed to attend but not done so) found erring/guilty, does your good office (i.e. Director Vigilance) plan to take action against them?
v) If yes, in how much time & shape i.e. penalty/punishment/department enquiry or any other?
Since Mr Kaushik said he did not receive any reply from the PIO, he filed first appeal with the First Appellate Authority (FAA). The FAA in his order stated that the PIO had given the reply within the stipulated time, which is given below:
i) A complaint dated 13 November 2006 was received from RK Kaushik, in through CBI vide No DLI/Anti Corruption Branch/Complain/CA 2865/06/8123 dated 8 June 2007 the complaint was forwarded to RCS vide letter dated 11 July 2007 for taking necessary action at their end.
ii) The requisite information pertains to office of the RCS, Government of National Capital Territory of Delhi (GNCTD), in the view of above a copy of the RTI application is being transferred u/s 6(3) of RTI Act to the PIO RCS for furnishing information.
iii) As above.
iv) As above.
v) As above.
The FAA, later said, "The appellant sought names and details of the officials who were assigned investigation of the complaint made by the appellant. Since the complaint was forwarded by the Directorate of Vigilance to the officer of the RCS for necessary action, such information could be provided by the office of RCS. Hence, the PIO's decision to transfer the application of the appellant was correct. He was in no position to supply information sought vide point Nos. 2, 3, 4 and 5 of the application. During the hearing the appellant did not inform if he received any reply from the PIO of RCS in respect of the transferred application."
Not satisfied with the reply received from the FAA, Mr Kaushik then filed the second appeal before the CIC. During the hearing on 10 November 2008, the Commission noted that the appellant had filed a complaint about corruption and embezzlement to the tune of Rs39 crore alleging that officers of the Registrar of Cooperative Societies were involved with the CBI. The CBI sent the complaint to the Director of Vigilance.
"The information provided by the PIO to the appellant was that the complaint was in turn forwarded to the RCS by the Director of Vigilance. This is appearing a little bizarre since it is difficult to understand what purpose will be served by sending a complaint to the body against whom the allegations are made," Mr Gandhi, the CIC, said.
While allowing the appeal, the Commission then directed the PIO of the Director of Vigilance to provide the letters and notings which evidence the process of deciding to send this case to the RCS before 30 July 2009.
Decision No. CIC/SG/A/2009/001370/4110
Appeal No. CIC/SG/A/2009/001370
Appellant : Rajinder Kumar Kaushik
New Delhi-110003
Respondent : Amitabh Joshi
Public Information Officer
O/o the Director (Vigilance)
Delhi Secretariat, I. P. Estate,
New Delhi-110002
Only heavy users of ACs are sure to recover the extra money they shell out for an AC with a...


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The radical changes are part of a number of recommendations made by the committee after it met in Dubai, a statement from the game's governing body said in London on Saturday.
The experiments would have to be approved by the chief executives of the Test playing nations who are to meet at London in June before these are implemented.
Other important changes suggested included playing 12-member teams with different batting and bowling elevens in a One-day match. This means, Sourav Ganguly and other captains can pack their side with seven batsmen and still have five specialist bowlers.
And scrapping of overthrows as a result of the ball rebounding from a batsman's body or bat while allowing extra runs arising out of the ball hitting the stumps has also been suggested.
A typical instance of 'double-play' to be put on trial would be an appeal for leg before and the umpire considering it while the batsmen steal a single; then the appeal is upheld while at the same time a fielder runs the non-striker out.
The batsmen will also gain more advantage over the bowlers in the shorter version of the game, as they will have the liberty of dictating the opposition in which over to apply the field restrictions. Moreover, the restrictions need not be in 15 successive overs.
The committee, chaired by former Indian captain Sunil Gavaskar, also suggested that the minimum number of overs to constitute a One-day International be reduced to 20 from 25.
In One-day matches where the play begins on a reserve day, there shall be no re-toss or change in eleven made on the first day unless the two captains arrive at an agreement.
Tests and One-day Internationals that are abandoned without a ball being bowled may be included in records, provided the toss has been made.
With regard to play time lost in Tests, it may be made up on the same day by extending play up to an hour and on subsequent days by up to half an hour but at no point of time more than one hour of extra time may be played on any one day.
Clause 16 of Test Playing Conditions may also be amended so as to make it clear that in the event of playing time lost for any reason, it should be time lost that has to be made up and not overs lost.