text:
Conserved roles for Polycomb Repressive Complex 2 in the regulation of lateral organ development in Aquilegia x coerulea 'Origami'
Development and cell biology
Epigenetic regulation is necessary for maintaining gene expression patterns in multicellular organisms. The Polycomb Group (PcG) proteins form several complexes with important and deeply conserved epigenetic functions in both the plant and animal kingdoms. One such complex, the Polycomb Repressive Complex 2 (PRC2), is critical to many developmental processes in plants including the regulation of major developmental transitions. In addition, PRC2 restricts the expression domain of various transcription factor families in Arabidopsis, including the class I KNOX genes and several of the ABCE class MADS box genes. While the functions of these transcription factors are known to be deeply conserved, whether or not their regulation by PRC2 is similarly conserved remains an open question.
Here we use virus-induced gene silencing (VIGS) to characterize the function of the PRC2 complex in lateral organ development of
PRC2 targeting of several floral MADS box genes may be conserved in dicots, but other known targets do not appear to be. In the case of the type I KNOX genes, this may reflect a regulatory shift associated with the evolution of compound leaves.
Maintenance of proper gene expression in differentiated cells is essential for the development of multicellular organisms and epigenetic regulation is an important player in this process Reviewed in:
PRC2 is involved in a number of important developmental transitions. In the plant model system
In addition to its role in developmental transitions, PRC2 has been suggested to function in lateral organ development in
While the functions of the floral ABC class and type I KNOX genes are thought to be conserved across angiosperms, comparative studies of their regulation have largely focused on upstream transcription factors, such as
In the current study we have used VIGS to knock down the expression of
Virus-induced gene silencing
Additional file 1
Table of all PCR primers.
Click here for file
RNA was extracted from control (
Amplification was performed using AccuStart PCR SuperMix (Quanta Biosciences Inc, Gaithersburg, MD). The amplification program began with 1 minute activation step at 94°C, followed by a 20 second denaturing step at 94°C, a 15 second annealing step at 55°C, and a 15 second extension at 72°C, repeated for 30 cycles. This cycle number was chosen for optimal detection of
cDNA was prepared from VIGS-treated tissue as described above. For the carpel sample, carpels were collected from 3 anthesis stage wild type plants and pooled together. RNA was extracted using the RNeasy Mini Kit (Qiagen, Valencia, CA) and treated as described above. cDNA from VIGS-treated tissue was then pooled together and diluted 1:10. The control sepal pool consisted of
Petals from wild type,
We treated both unvernalized and vernalized plants with TRV2 constructs containing either
Vegetative phenotypes
Wild type
Figure 1
Vegetative phenotypes of PRC2 VIGS-treated plants.
Vegetative phenotypes of PRC2 VIGS-treated plants. A.
Additional file 2
Heteroblasty in
Click here for file
We observed
Floral phenotypes
Wild type
Figure 2
Floral phenotypes of PRC2 VIGS-treated plants.
Floral phenotypes of PRC2 VIGS-treated plants. A-C.
Additional file 3
The PRC2 regulates carotenoid production in
Click here for file
Assessment of AqFIE and AqEMF2 down-regulation
Due to limited RNA availability, we used standard RT-PCR to assess target gene down-regulation in leaves, sepals and petals compared to their expression in
Figure 3
RT-PCR expression data in PRC2 VIGS-treated leaves.
RT-PCR expression data in PRC2 VIGS-treated leaves.
Figure 4
Expression of
Expression of
Additional file 4
Additional candidate gene expression in PRC2 VIGS-treated leaves. A. Expression of
Click here for file
Assessment of candidate gene expression
We tested for ectopic expression of a wide panel of potential target genes, with a focus on the floral organ identity loci and type I KNOX homologs (Figure
Figure 5
Expression of candidate genes in PRC2 VIGS-treated floral organs.
Expression of candidate genes in PRC2 VIGS-treated floral organs. A. Expression of several floral organ identity genes in
Next, we tested for up-regulation of three of the five
Lastly, in an effort to investigate the carotenoid production, we identified the likely
It is interesting to note that in
In our analysis of candidate target genes, we found that
The class I KNOX genes are directly or indirectly regulated by PRC2 in both
There are several possible explanations for why we did not observe significant ectopic KNOX gene expression in our VIGS-treated leaves. First, it is possible the KNOX genes were ectopically expressed early in leaf development when the higher order branching actually developed, but were later down-regulated by redundant mechanisms, such as
In addition to the conserved role in regulating
• A critical role for PRC2 in maintaining the repression of
• Class I KNOX genes are not ectopically expressed in PRC2 down-regulated tissue in
• This study, the first to examine PRC2 function in angiosperms outside
Competing interests
The authors declare that they have no competing interests.
Authors' contributions
EJG helped to conceive of the study, carried out the experiments, and drafted the manuscript. EMK helped to conceive of the study, supervised the experiments, and helped draft the manuscript. Both authors read and approved the final manuscript.
The authors would like to thank members of the Kramer lab and 2 anonymous reviewers for critical comments on the manuscript.
Epigenetics: an overview
Epigenetics, an emerging discipline with broad implications
A gene complex controlling segmentation in Drosophila
Diversity of Polycomb group complexes in plants: same rules, different players?
Interpretation of developmental signaling at chromatin: The polycomb perspective
Regulation of cell identity by plant Polycomb and trithorax group proteins
Silencing by plant Polycomb-group genes requires dispersed trimethylation of histone H3 at lysine 27
Nucleosome binding and histone methyltransferase activity of Drosophila PRC2
Polycomb group and trithorax group proteins in Arabidopsis
Positive darwinian selection at the imprinted MEDEA locus in plants
Expression, imprinting, and evolution of rice homologs of the Polycomb group genes
Polycomb Group proteins: an evolutionary perspective
The Polycomb-group protein MEDEA regulates seed development by controlling expression of the MADS-box gene PHERES1
EMBRYONIC FLOWER2, a novel polycomb group protein homolog, mediates shoot development and flowering in Arabidopsis
The VERNALIZATION2 gene mediates the epigenetic regulation of vernalization in Arabidopsis
A polycomb-group gene regulates homeotic gene expression in Arabidopsis
Vernalization-induced flowering in cereals is associated with changes in histone methylation at the VERNALIZATION1 gene
Polycomb group gene function in sexual and asexual seed development in angiosperms
A Polycomb Repressive Complex 2 gene regulates apogamy and gives evolutionary insights into early land plant evolution
Regulation of stem cell maintenance by the Polycomb protein FIE has been conserved during land plant evolution
The ABC model of flower development: then and now
Expression of the Arabidopsis floral homeotic gene agamous is restricted to specific cell types late in flower development
Genes directing flower development in Arabidopsis
Function and specificity of Hox genes
SEPALLATA3, FT and FLC genes as targets of the Polycomb group gene CURLY LEAF
Chromatin regulation of plant development
Homologies in leaf form inferred from KNOXI gene expression during development
FIE and CURLY LEAF polycomb proteins interact in the regulation of homeobox gene expression during sporophyte development
Revelation of ancestral roles of KNOX genes by a functional analysis of Physcomitrella homologues
The floral regulator LEAFY evolves by substitutions in the DNA binding domain
The expression domain of PHANTASTICA determines leaflet placement in compound leaves
Aquilegia as a model system for the evolution and ecology of petals
Aquilegia: A new model for plant development, ecology, and evolution
Virus-induced gene silencing as a tool for functional analyses in the emerging model plant Aquilegia (columbine, Ranunculaceae)
Sub- and neofunctionalization of APETALA3 paralogs have contributed to the evolution of novel floral organ identity in Aquilegia (columbine, Ranunculaceae)
Petal-specific subfunctionalization of an APETALA3 paralog in the Ranunculales and its implications for petal evolution
Elaboration of B gene function to include the identity of novel floral organs in the lower eudicot Aquilegia (Ranunculaceae)
The Aquilegia FRUITFULL-like genes play key roles in leaf morphogenesis and inflorescence development
Characterization of
The control of flowering time in the lower eudicot Aquilegia formosa
Carotenoid sequestration in plants: the role of carotenoid-associated proteins
Localization of a flavonoid biosynthetic polyphenol oxidase in vacuoles
Carotenoids in nature: insights from plants and beyond
Transcriptional control of SET domain group 8 and carotenoid isomerase during Arabidopsis development
The Arabidopsis trithorax-like factor ATX1 functions in dehydration stress responses via ABA-dependent and ABA-independent pathways
Floral ontogeny of Aquilegia, Semiaquilegia, and Isopyrum (Ranunculaceae)
Complexes of MADS-box proteins are sufficient to convert leaves into floral organs
Developmental and evolutionary diversity of plant MADS-domain factors: insights from recent studies
The 'ABC' of MADS domain protein behaviour and interactions
Arabidopsis REF6 is a histone H3 lysine 27 demethylase
Separable whorl-specific expression and negative regulation by enhancer elements within the AGAMOUS second intron
Regulatory elements of the floral homeotic gene AGAMOUS identified by phylogenetic footprinting and shadowing
The making of a compound leaf: genetic manipulation of leaf architecture in tomato
ASYMMETRIC LEAVES1 and auxin activities converge to repress BREVIPEDICELLUS expression and promote leaf development in Arabidopsis
Direct repression of KNOX loci by the ASYMMETRIC LEAVES1 complex of Arabidopsis
Maize rough sheath2 and its Arabidopsis orthologue ASYMMETRIC LEAVES1 interact with HIRA, a predicted histone chaperone, to maintain knox gene silencing and determinacy during organogenesis
The ASYMMETRIC LEAVES complex maintains repression of KNOX homeobox genes via direct recruitment of Polycob-repressive complex2
Carotenoid metabolism: biosynthesis, regulation and beyond


text:
is my truck stock suspension or lifted?
I have a 2001 ram 1500 5.2L 4x4. I just bought it and had it shipped down to Honduras where I am working. It has a lot of miles, so I'm having a lot of work done here (as labor is cheap), but I have a question about my suspension.
It has rancho shocks on it RS5500's. Front: RS5197 Rear C152B
The front, RS5197 (according to rancho's site) are the stock replacement shock, and I can't find info on the rear.
The front end is pretty level, and I can't determine if there is a slight lift to the truck. The center of the rear wheel well measurs approximately 40", and the front 39" with 275/75 R16 tires. There has been some cut out in the wheel well for the front tires.
Basically, I want to put 35" tires on, and replace my shocks due to the rough ride on the bumpy roads here, but I'm not sure if I can just replace the shocks without lifting it. It looks like I have room for the tires.
How can I tell if this has been lifted, leveled, or nothing has been done?
any input is appreciated.
ok, so I am utterly confused. I watched a video on youtube of someones lift kit, and I'm starting to think mine is just the stock lift. It only has one lift block on the rear.
If my lift was only stock, would it be able to fit the 275/75 16R (32")? There is some cut out inside the wheel wells.
Thanks, any help?
wow, the #1 dodge forum, and no one can help me with what I thought would be a simple answer.
Not that anyone seems to be reading this, but:
O.K. I made a mistake when I mentioned the tire size; they are actually 285/75 16's on the rear and 265/75 16R on the front (that's f'd up)
Here is a pic. I've been trying to figure this out for two weeks and finally asked for help before I spend a lot of money on a lift. I don't want to find out I already have one.
Any input is appreciated
You don't have a lift...and you should run all 4 tires the same size on a 4x4, unless you never use the 4x4. That's because you'll cause drive train bind and destroy your transfer case. Your factory rear block is OEM.
You should be able to run 285's on all 4 corners without a lift. Rubbing may vary or be non existent, depending on a stack of variables I can't control.
Sorry no one answered right away. BTW...your question is one of the most asked ones for 2nd gen ram owners, and seasoned vets probably get tired of answering it. At least you weren't asked to do a search...
As for 35 inch tires, the minimum lift required is 3 inches, and that can be pretty tight. Five inches gives the suspension more room to work. Since you live in a country where I'll hazard parts are not easy to get, I'd stay with 33 inch tires and a stock suspension. Personally I think Rancho stuff is crap. Order in some good Bilstien shocks to handle the poor roads.
Good luck with your truck nicraage
I certainly appreciate your response. I realize people can get tired of these questions, but I've been searching for over a week on this, what confused me were the aftermarket shocks.
I've been leaning towards a rough country 5" lift, it seems to be the most bang for the buck, and I should be able to get one shipped to my apo.
I didn't realized my tires were different sized until today. I've only put it in 4wd a couple times on some dirt roads, but it felt very strange, and I've been worried about it. When I get new tires (which I need), I'll throw it in 4x4 again and see how it feels. Worst case, I'll have it rebuilt. (Labor for my full transmission rebuild was about $260 from a mechanic with a good reputation and a specialty in transmissions).
If I get 285's now, and put on the 5" lift later, would those tires , would those tires look too small?
My truck has 285's and a 5 inch lift. I think it looks fine and I don't rub on road or off. I hate my R/C shocks that came with my lift. I would buy better shocks (Bilstiens) if they are avalible.
Body lift is definately in order, mine is 4 " and 14.5x36x15s were definately maximum, but I hated driving around with those crackfinders, the geometry those big dia tires were just too much for the design limits of my steering, sometimes it was downright scary how the truck chased every crack in the road. Try this, on dry pavement, stand in front of your truck and have someone else wiggle the steering wheel back and forth a little, the front of your truck, beginning at the front of the cab will wiggle its nose, just like a bunnyrabbit. taller tires magnifies this, thus driveability is affected, I've heard someone makes a bracket to stiffen these trucks frames up, but I've become quite happy with a shorter tire, and they don't look stupid, even with the 4" body lift. I would think you may need an 85 profile with that large of a tire for an 8" wide rim, but I'm not certain.
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Surface Marker Buoy's (SMB) are now a requirement for all divers. If you don't dive with a SMB you need to start now. It makes sense to be safe. XS Scuba's Safety Tube is a Durable Urethane Coated Nylon SMB that measures 6" (1.83 meters) in length, has a circumference of 9" (22.9 cm) and is Bright Orange in Color for High visibility when inflated on the surface. Safety Tube rolls up compact and comes with its own Mesh Bag with Snap Clip. The Compact Size 5" x 3" (12.7 x 7.6 cm) fits securely in your BCD Pocket or can be clipped to your gear for easy access when needed.
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This product has a limited warranty of 24 months.
Reviewed by 3 customers
Small, compact easy to store safety sausage. Excellent for travel to warm/calm water diving. Wouldn't use as primary safety sausage in rough water found in North East US.
I used this SMB on a recent trip to Cozumel. It works just fine. I was storing it in my BCD pocket and eventually lost the little bag it came in. I was happier without the bag. The bag as that was a bit of a fumble to deal with at depth.
Would be much better if made of reflective material.


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Need advice on 2.5yo
My son who's two and a half...I'm having a few issues with him. #1...I can't get him to eat anything other than pbj, grilled cheese or crackers. Anyone have tips about this? I want him to eat better.
#2...I want to switch him to the hard spout sippy cups but he only wants the soft Nuk ones that he has now chewed through. Any advice on making the switch?
Thanks in advance
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text:
Ok class, listen up - quiz time. Who made the following comments?
"In the 20th century, the Soviet Union made the state's role absolute. In the long run, this made the Soviet economy totally uncompetitive . . . I am sure nobody wants to see it repeated. Nor should we turn a blind eye to the fact that the spirit of free enterprise, including the principle of personal responsibility of businesspeople, investors, and shareholders for their decisions, is being eroded in the last few months. There is no reason to believe that we can achieve better results by shifting responsibility onto the state."
Newt Gingrich? Nope.
Ron Paul? Nope.
Rush Limbaugh? Nope.
Lou Dobbs? Nope.
Give up . . . ?
Russian Prime Minister Vladimir Putin. That's right. He sounds like more of a free-market supporter than our own President. I've been adducted by aliens and transported to a parallel universe.


text:
The Syracuse Orange will start the season off by being ranked as high as No. 7, but are they overrated or underrated entering the 2013-14 college basketball season?
Neither. I don't necessarily agree with their ranking, but I do agree with them being one of the best teams in the ACC. I would have ranked them a little lower, but their talent cannot be denied.
Michael Carter-Williams is the biggest departure, but a freshman will come in and take over right away. Tyler Ennis has the chance to make an immediate impact. He is ranked No. 20 and is a five-star recruit (according to ESPN). He could be one of the top freshman in the country and has the chance to prove that right away–assuming he is the starting field general.
What will make Syracuse so hard to beat is that infamous defense. The Orange always have a very stingy defense and that will not change in the upcoming season.
C.J. Fair also returns. He is one of the best players in the nation and he should put up even better numbers than what he did in the 2012-13 season. He averaged 14.5 points per game and seven rebounds per game last season. Fair is not getting as much hype as Andrew Wiggins or many of Kentucky's freshmen, but he could still wind up being the player of the year.
Duke and North Carolina have dominated the ACC for a very long time, but the Orange could steal the conference title in their first year.
Syracuse is getting the right amount of hype entering the season and it will have the talent to make a second straight Final Four trip.
If you're a tweeter feel free to follow me @TheTrevorLowry or add me to your network on Google.


text:
James Ballowe
Engagement Advisor
James Ballowe is Distinguished Professor Emeritus of English at Bradley University. Since retiring from university teaching and administration, Jim has written a biography of Joy Morton and a monograph history of The Morton Arboretum. For many years he taught natural history writing and environmental ethics at The Morton Arboretum.
Jim has also edited an historical anthology titled Christmas in Illinois and served as the assistant editor for poetry for City Creatures. Jim is a founding editor of the literary magazine "Fifth Wednesday Journal" for which he conducts interviews with featured poets. Since publishing a collection of the philosopher George Santayana's essays in 1967, he has received several awards for his poetry, essays, and books. He is currently working on a book of his poetry and a book of his essays about the State of Illinois.
Contributions to HumansandNature.org:
- Life in the Ruins
A City Creatures blog post.
- Revisiting Sand County: An Interview with Estella Leopold
From Minding Nature's September 2016, Volume 9, Number 3 issue.
- Conversation with Gavin Van Horn
From Minding Nature's May 2016, Volume 9, Number 2 issue.


text:
Description Edit
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2. Coat meat in corn flour, dip them in beaten egg, then roll in Panko breadcrumbs and transfer to baking dish which is greased with olive oil. After it is done, sprinkle olive oil on top of the breaded chicken. Baked in oven at 250º C for 30 minutes.
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text:
Tags: backdoor, NSA, Privacy, RSA, Secret, security, Security Firm.
Posted 12/23/2013 at 2:18 PM
Posted 4 years ago
Security firm, RSA won't admit it. It is believed that the RSA was paid off by the NSA to use a crooked random number generator.
The problem with the random number generator, the "Dual Elliptic Curve Determinitic Random Bit Generator" is that it is wrought with serious weaknesses. Crooked. Brought on board to configure with some RSA products in 2004, and a scant 3 years later its flaws were showing.
Protected data would be readily available to be spied on, as a result of the RSA's haywire contraption. It is here in the story that the backdoor for the NSA becomes their point of entry.
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text:
Garuwa St 1
House, Fingal Bay
From $189 per night {{quote.pricing.message}} Total {{quote.pricing.price | format:'currency':'short'}} for
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Please note that the garages are not in use but there is off street parking available.
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1 Car Spaces
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Add your logo to custom pens that seem to do it all! These 4-in-1 pens combine a stylus, ballpoint pen, screen cleaner and smart phone holder all into 1.
The promo BIC WideBody Retractable ballpoint imprinted pen with soft ergonomic rubber grip features an extra large imprint area to promote your logo.
Sleek retail design custom pen is a rollerball pen on one end and liquid highlighter on the other.
These promotional pens are fun to play with, fun to write with, and it will get your logo noticed.
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Custom Imprinted round Golf Pencil is a sure way to get some brand exposure on the golf course.
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text: Asian markets surged on Wednesday, as Wall Street's rally gave investors the impetus they needed to resume yen carry trade positions and buy heavily into the last week's declines.Hong Kong and China led the giant rally, with the key indices soaring 4.9% each. The Hang Seng rose 1362 points, to 29,166, while the Shanghai Composite Index jumped 254 points, to 5412. "There are quite a lot of discounts now in Hong Kong after the last few days," says Conita Hung, head of equities at Delta Asia Finance in Hong Kong. "Liquidity is still plentiful on the mainland and interest rates are still on a downtrend in the U.S. and Hong Kong. China is increasing


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Thursday Afternoon Acting Group Presents "The Brothers Grimm: Out of Order," April 21-22
The Thursday Afternoon Acting Group (TAAG) at the University of South Carolina Upstate will present their spring semester play, "The Brothers Grimm: Out of Order," April 21-22.
Performances will be held at 7:30 p.m. Thursday and Friday in the studio theatre located in the Humanities and Performing Arts Center on the campus of USC Upstate.
The 50-minute play is about brothers Jake and Will Grimm who just can't seem to get on the same page when writing a script. The story is a complete mess as plots are intermingled, pages are swapped and characters from different short stories hope to live happily ever after!
Tickets are $3 and can be purchased at the door or by calling Rich Robinson, director of the Thursday Afternoon Acting Group, at (864) 503-5621.
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Doctor insights on:
Home Remedies For Severe Itching
Recurrent severe itching in vulva. Reasons? Treatment
Infection vs allergy: There are several types of infection that could cause this. It could also be some type of allergic reaction. The most common finding would be a yeast infection. I would advise a trip to see your healthcare provider to get an assessment. There is no way to tell what the cause is without doing some testing and looking at the condition so i can not recommend a treatment. ...Read more
Severe Itching (Definition)
Severe itching is a symptom in which a person has extreme itching on part or all of his body. Itching can be due to allergic reactions, drug side ...Read more
What are the causes of severe itching and rashes in tuberculosis treatment?
Drug allergy: Itching and rash may be a sign of an allergic reaction to one of the drugs being used to treat tuberculosis. You should talk to your doctor about these signs and symptoms, the drugs may need to be changed. ...Read more
Have had treatment from my doctor for folicalitis 2x & scabies 6x but still HAVe seveRe ITCHINg?
Itchy rash: Scabies may cause itching for some time after treatment but this is prolonged itching. Make sure there is no re-infection or another cause of this itching. Need to talk to your physician about seeing a dermatologist ...Read moreSee 1 more doctor answer
Severe itching during pregnancy herbal treatment?
Another option: One very safe option for itching during pregnancy is acupuncture. ...Read more
There is crusting on my feet and on the back it has some small bubbles and often severe itching. Any treatment for this?
Yes: It sounds like athlete's foot, a common fungal infection of the skin on the feet. Try using an over-the-counter medication like Lamisil (terbinafine) or lotrimin. Use the medications as directed, and if it doesn't improve or worsens, see your doctor. It might be another problem, requiring a different course of treatment. ...Read more
I have lice and am doing treatment this evening. I am so uncomfortable and embarrassed over the severe itching. What can I do about the neck rash?
ITCHING, ALLERGY...: You definitely need head lice treatment. For itching and neck rash, use otc Hydrocortisone cream 1% twice daily on the rash, take otc Claritin (loratadine) 10 mg once daily. If not better, talk to your doc. ...Read more
My mother has severe itching between her toes, the skin of the area becomes white and she peels it off by her nails.what causes this.what is treatment?
Probably : fungal infection get some tolinaftate cream use it twice a day for two weeks ...Read more
Redness and crusting on the back of my hands and legs. They have some small bubbles and often get severe itching. Any treatment for this?
See below.: It might be a skin disease such a psoriasis . You will benefit to be seen by dermatologist. ...Read more
My brother has suffered from very severe itching all over his body for about 8 years now. He itches right after bathing or when he sweats. ?
Cholinergic ?: If he has itchy bumps also, then it is called cholinergic urticaria which flares up after the body gets heated up then cools off. This can often be prevented by taking an antihistamine such as zyrtec (cetirizine). It may go away by itself with time but is not a serious health issue. ...Read moreSee 1 more doctor answer
Have boils in hair, causes severe itching.
It getting automatically cured and coming again. what might be the reason and remedies to cure this.
Furunculosis: The boils in your scalp represent an inflammation of hair follicles. The treatment consists of appropriate shampoos/topicals and oral antibiotics. This condition can be challenging and requires the expertise of a Dermatologist. ...Read more
Itch (Definition)
Itches are a clinical finding in which a person's skin has a sensation of non-painful irritation ...Read more
- Talk to a doctor live online for free
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- Talk to a dermatologist online


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People often frame pictures of their favorite things, such as their children or neighborhood children who get better grades. Showcase what matters with this Groupon.
Choose from Four Options
- $59 for a two-hour Shoot and Share or Photographing in Low Light class for one (a $179 value)
- $99 for a two-hour Shoot and Share or Photographing in Low Light class for two (a $358 value)
- $199 for a two-hour Shoot and Share or Photographing in Low Light class for four (a $716 value)
- $99 for a Shoot and Share class and Photographing in Low Light class for one (a $329 value)

During a 45-minute Shoot and Share class, an instructor introduces and expands on topics such as composition, lighting, color, and lens choice. Students implement their new knowledge on a photo safari down Central Avenue. Classes are capped at 15 students and held on Wednesday and Sunday evenings and Saturday mornings.
Photographing in Low Light helps photographers pull good images out of dark conditions by explaining ISO, light meters, and methods for using an on-camera flash judiciously. After a 45-minute lecture and demonstration, class adjourns to survey the city's nightlife and test their newly learned techniques. This class requires a tripod and is held twice a month on Monday nights.

The Low Light photography class has been canceled. Customers can redeem their Groupon toward the Shoot and Share class through the expiration date.
NorthLight Photography
A mop of hair fringes an infant's milky-white face, his plump cheeks reminiscent of a porcelain doll. Though the image is black and white, the boy's eyes are as striking as any baby blues—reflections of the white linens gathered around his legs add depth and life to his playful gaze. This photograph, which won Janet Boschker the Canon Par Excellence Award in 2010, is but one of many that have earned the photographer numerous accolades.
At Northlight Photography, the Boschker's own studio, the photographer flaunts her signature blend of award-winning artistry in custom portraiture. Whether capturing the innocence of a child, the love of a family, or the excitement of a special event, she strives to turn each image into an artistic and timeless representation of its subject. The expert also shares some of her trade secrets through introductory and advanced photo classes.


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A History of the County of Somerset: Volume 5
Index INDEX Note. An italic page-number denotes an illustration on that page or facing it. The pages containing the substantive history of a parish or hundred are indicated by bold-face type. A. Abernethy, Jas., 147 Abingdon (Berks.), abbey, 157...View result
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Parishes: Stogumber
A History of the County of Somerset: Volume 5
The village expanded southeast of the church to Zinch ( sentes, thorns) ... in the 1970s was again concentrated at Zinch. There are references to open arableView result


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New Delhi: Former Indian skipper Mohammad Azharuddin, facing a possible life ban for match-fixing, was given a final hearing by Board of Control for Cricket in India (BCCI) officials on Tuesday, along with four other implicated players.Azharuddin arrived discreetly at the hotel and took the service lift to avoid waiting reporters and television crews. Tuesday's hearings with BCCI president and Disciplinary Committee chairman Dr A C Muthiah were to focus on a separate BCCI probe that named the same five players, with Azharuddin identified as the chief culprit.The other four players, with the exception of Mongia, were found to have links with bookies. "We have to take action, or else we would be seen as shielding them," Dr Muthiah said on Monday."We will be taking deterrent action I can assure you. The maximum penalty the BCCI can give is a life ban," he added. The final decision of the BCCI will be announced in Calcutta on November 29.Former Test all-rounder Manoj Prabhakar, who first set the cat among the pigeons in 1997 when he alleged that Indian cricket icon Kapil Dev had offered him money to under perform, told reporters he was innocent of any wrongdoing."I've just told them that during my cricket career I did nothing wrong," Prabhakar said after emerging from his hearing. "I left cricket in 1996 and everybody knows what I've been doing for the last four years," he said, referring to his repeated allegations of rampant match-fixing.Both the CBI and BCCI reports exonerated Kapil Dev.
Cricketers arrive for BCCI panel meet
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Virat Kohli Scores 75 Off 51 Inspite Of Palm Injury, Stitches Needed
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Chris Gayle Struggling In IPL, Is It The End For Universal Boss


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[News Clip: South Dallas Reinvestment Package ]
Description: Video footage from the KXAS-TV/NBC station in Fort Worth, Texas, covering a news story about the lack of investment capital available to home and business owners in South Dallas. Savage Beauty Supply owner Robert Walker is featured as a recipient of First Community Bank's community reinvestment program. This story from reporter Mona Logan aired during the 6PM news.
Date: May 30, 1998
Creator: KXAS-TV (Television station : Fort Worth, Tex.)
Item Type: Refine your search to only Video
Partner: UNT Libraries Special Collections


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My son was diagnosed with Brucillosis on June 1st 2016 and is under medication (gentamicin for 15 days, Doxycycline 100mg /per day + Rifampicin 300mg / per day) and is in the 6 Week of medication now. The latest thing is that when ever he has to urinate i have observed that the front portion of his penus is enlarged in a bulb like manner. After urination it returns to normal and as of now he does not complain of any pain. I am worried kindly let me know what could be be the cause and what is the remedy. Is there an urgency to consult a doctor.
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Better to consult a paediatrician or surgeon. He may have phimosis or pin hole meatus.
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Do you have a photo of Jesse?
Lost on October 29, 2015 in Salt Lake City, Utah.
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Mt. Eaton Collection
Take advantage of those unused corners in your living room with one or two of our Amish corner curio cabinets. DutchCrafters customers love the space saving advantages of an Amish handcrafted corner curio cabinet. Choose from a variety of hardwood options and finish options for our curio cabinets to match to existing furniture or just suit your style.
© Copyrights 2003 - 2017 DutchCrafters All rights reserved.


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December 15, 2014 Total Views: 5991 Today: 4 ★★★★
Solo Sokos Hotel Torni Helsinki, This grand 1920s hotel is within 5 minutes' walk of Helsinki Central Station and the Esplanadi shopping streets. It offers free WiFi, a popular breakfast buffet and a rooftop bar with panoramic city views. Solo Sokos Hotel Torni Helsinki's modern, soundproofed guest rooms are decorated in 3 different styles: Art Nouveau, Art Déco and Functionalism. All have an LCD TV with cable channels and a private bathroom with shower. Some include a seating area. Restaurant Torni serves a seasonal menu of traditional Finnish dishes inspired by modern, international flavours. During summer, the hotel's Irish pub hosts live music and entertainment on its terrace. The elegant 14th-floor Ateljee Bar offers regular exhibitions of works by young Finnish artists. (Solo Sokos Hotel Torni Helsinki hotels booking).


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"We started out ok, we lost our first game. I played tough, I took some hits but was pleased overall on how I played. We got Jones High from Orlando up next."
Lee, 5-foot-10 and 185 pounds, talked about the latest with regards to recruiting.
"BCU, South Alabama, Iowa State, and Middle Tennessee have been calling lately," he said. "They're showing interest."
Lee isn't ready to single out any favorites just yet.
"Right now I don't have a favorite. It'll be easier to narrow it down once I visit some schools."
The standout running back is hoping to land some offers so he can begin taking visits, too.
"I don't have any official visits scheduled yet. Once I get offered from a school I'd like to go visit them."
Inside the classroom Lee claims a 2.7 GPA and a 15 ACT score.


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One of the key points that I have been emphasizing to leaders, faculty and staff at the start of this school year has been accountability. One of the aspects of accountability is that you either need goals or rules to which you are accountable. My approach to rules is that we must have them to make sure we work well together as a community. They provide a comfortable zone where we can all work to achieve the Mission of MCA. Without them we have chaos and everyone doing what is pleasing in their own eyes. Reading through the book of Judges reinforces that allowing everyone to do as they please is a model for disaster. So my belief is that if you are going to have a rule, then enforce it. Or if not, then do away with the rule.
Now I have been in environments where the rules became more important than relationships. Compliance to those rules became the measuring stick for spirituality. Therefore, I am not interested in operating in that model. I want us to have reasonable guidelines that have explainable rationale as to why we have them. Then we must enforce those rules in love and fairness. If we follow this path with the knowledge that we are all sinners and that we will make mistakes (break the rules), then our hearts must be desirous of restoration. Every situation will be different. Every child will be different. Therefore we must administer grace, justice and consequences in a loving, wise manner…individually. We are not perfect, so we will error at times in administering corrective, restorative actions, but by the grace of God, we will strive to be God's instruments to help young people be trained and equipped to love and serve our Lord.


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Chesapeake Energy Corp. said it decided to trim compensation for outside directors by 20% and eliminates the use of fractionally owned aircraft for personal travel by outside directors.
Under the natural gas producer's new plan, effective immediately, outside directors will receive annual pay of $350,000, comprised of $100,000 in cash and $250,000 in equity. The company said the reduction puts its pay package at or below the average director compensation of its peers.
The change was taken with the aid of an independent compensation adviser as part of a broader review of the company's executive compensation programs. The board has made a handful of compensation changes, including reducing Chief Executive Aubrey McClendon's pay for 2011 and retaining an independent compensation adviser for the board's compensation committee.
The board also said the search for a new non-executive chairman is progressing. Chesapeake's directors have forced McClendon to step down as chairman, bowing to pressure from shareholders over his personal financial dealings and the stock's poor performance.
McClendon agreed to give up the chairmanship and end 18 months early a controversial perk that allows him to purchase a 2.5% stake in every well Chesapeake drills.
Earlier this month, Chesapeake confirmed that the Securities and Exchange Commission had opened an informal investigation focused on the company and McClendon. Also this month, the company said it narrowed its first-quarter losses amid lower derivatives losses.
Shares closed Friday at $14.36 and were down 2 cents after hours. The stock is down 36% so far this year.
Copyright (c) 2012 Dow Jones & Company, Inc.
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Jerry Premo | May. 19, 2012I would like to see all of the directors who voted for or allowed the president and his goons to take a share of company drilled wells to be fired or forced to resign and appoint a completely new board of directors.
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Acne is a undivided problem among both teens and adults, and, as much inhabitants desire treatment, more subject matter becomes going spare around thisability specification. Acne is not controlled to newly your external body part swathe but can feeling all another natural object surround. Unit disease of the skin is ne'er an superior shield and it can come about to somebody.
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Question: Create a dotplot for the following data set
Create a dotplot for the following data set.
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Answer to relevant QuestionsRefer to data given in Exercise 2.20 on the number of fatal motorcycle accidents in each of South Carolina's 46 counties during the year 2009. Create a dotplot for those data. The following data give the number of times each of the 20 randomly selected male students from a state university ate at fast-food restaurants during a 7-day period. Create a dotplot for these data and point out any ...A whatjapanthinks.com survey asked residents of Japan to name their favorite pizza topping. The possible responses included the following choices: pig-based meats, for example, bacon or ham (PI); seafood, for example, tuna, ...Construct the cumulative frequency, cumulative relative frequency, and cumulative percentage distributions by using the frequency distribution table constructed for the data of Exercise 2.73. The following data give the number of visitors during visiting hours on a given evening for each of the 20 randomly selected patients at a hospital. Create a dotplot for these data.
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Shani Gross/
Shani Gross is the Director of the Silicon Valley Beit Midrash, a new center of learning on the West Coast that empowers Jewish people of all backgrounds to study classic Jewish texts in a pluralistic, warm and intellectually challenging environment. She is passionate about exploring Jewish texts and creating communities around that pursuit. Before co-founding the Silicon Valley Beit Midrash, she studied in a number of Jewish institutions including Migdal Oz, the Drisha Institute and the Pardes Institute of Jewish Studies. Shani earned a dual degree in Jewish Studies and Marketing from Stern College at Yeshiva University. She lectures around the San Francisco Bay Area on topics relating to Tanakh and Midrash and how they speak to our modern Jewish community.


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McCall's 7062; ©1980; Carole Little for Saint-Tropez West - Misses' Blouses: Buttoned blouses are gathered into yokes with forward shoulder seams. Blouse A has tie collar, self-faced short sleeves, front and back tucks released at waistline. Blouse B has buttoned stand-up collar, short sleeves cut in one with fronts. Blouse C has collar; long sleeves with gathered cap are gathered into buttoned cuffs.
Links to reviews/blog postsEdit
- beththebooklady size 10 UNCUT
- New Vintage Studio Size 14, FF
Add a photo to the gallery by clicking the "modify" button below.
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Kramer operates complete parts, sales & service facilities in Regina, Saskatoon, Tisdale, Estevan, Swift Current, Kindersley and North Battleford as well as Kramer Rents – The Cat Rental Store. Kramer serves the industries of waste, road building, mining, oil & gas, agriculture, electrical power generation, material handling & forestry. Kramer customers range from major multi-national corporations and family-run construction companies to family-owned and operated farms.
Company details
- Business Type:
- Distributor
- Industry Type:
- Agriculture
- Market Focus:
- Locally (one state or province)
Vision, Values, Mission
Kramer has undertaken a long term strategic planning process to define our future business growth and development strategy. Part of this process included the definition of clear company vision, value, and mission statements. These statements permeate all of the decisions we make at Kramer and are regularly reviewed with employees and management to ensure the Kramer team is in full alignment.
We deliver industry-leading people, support and products to the communities we serve through safe and eco-focused practices.
Our relationships with customers, employees and community are built on the foundation of environment, family, growth, honesty, integrity, mutual success, respect and safety.
We take pride in making our customers more profitable by providing safe, innovative, cost-effective solutions.


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A group of us nearly walked right into the champion horse, Fields Of Omagh, at the Docklands on Friday. He was standing passively under a blue gown while two slender models kept vigil at his flanks, smiling the hours away in black miniskirts while the shakers of the racing world drank beer and swooned about all three of them.
The crowd was inside a long warehouse for lunch, an event put on by a networking company to promote the Cox Plate. Footage of Fields Of Omagh was rolling on giant projectors, and everywhere on the walls you could see him coming down the stretch at Moonee Valley, where he won two Cox Plates, three years apart. To my surprise, some in the crowd cheered the vision as he crossed the line.
It was loud enough in the warehouse to upset people, but Fields Of Omagh was unperturbed. In fact, he looked bored beneath his gown, perhaps pining for the paddocks already. What was happening in his mind, one wonders?
I've heard people say that you're either of the racing industry or you are not, and certainly its language does carry a cultish vibe, a threshold that cannot easily be crossed by throwing down an each-way bet on a horse in spring. And probably it's this language of punting, the way it parcels mysteries into neat, visible, numbers that makes the racing industry work.
But the way the racing world celebrates, and romanticises, its "champions" is more peculiar to me. It's something that requires a leap of faith as they say of the fables, or perhaps a specific experience with a horse would do it. Something sporting is lost, I think, when the sports' champions are not aware of their own status.
Standing at the end of his muzzle, however, it was obvious, even to me, that Fields Of Omagh is a magnificent animal. And his exploits as a racehorse are etched into records all about the place. But the devotion some people display, the deference to a horse's "career", for instance, remains beyond my imagining.
The champion, as he was referred to, was an unwitting participant in his own nostalgia. And knowing this, it can be hard to listen to people refer to the human qualities in a racehorse, for the same reasons it's difficult to listen to someone give complex instructions to their Pomeranian on the street.
Clearly, a horse does posses mystic qualities, beyond the friendly domain of dogs. But to say, for example, that a horse "has heart", or is somehow "a people's champion", does not ring true for everyone. What are the horse's reasons for trying so hard, for instance? What were the circumstances it overcame to inspire us?
Some people say you have to bet on a horse to really care about it, and this makes sense to me. Andrew Clarke, a vet who runs the Living Legends farm for retired horses, disagrees with this.
"A lot of the romance does come from the punt, but for a lot of people it's also about having a hero," he said. "It's not just that a horse has made someone money. Big races, especially the Melbourne Cup, mark specific periods in people's lives."
Clarke was at the lunch taking care of Fields Of Omagh, who now stays on his farm near Tullamarine, where he shares the space with other famous names such as Doriemus, Might And Power, Silent Witness and Rogan Josh.
According to Clarke, his old champions do have distinct personalities. They each have particular characteristics that can be separated and understood. Fields Of Omagh is like Roger Federer, he said, a gentleman and a champion. And Doriemus would be chess player in another life.
"Might And Power and Doriemus like carrots for treats," Clarke explained. "If you put carrots on the roof of the shed, Might And Power would kick the shed down to get them. Doriemus would go and get a ladder to climb."
David Hayes, the son of Dulcify's trainer, Colin Hayes, began speaking to the warehouse about Dulcify's famous Cox Plate win in 1979. The horse had won by seven lengths and was, as he put it, "a certainty" to win the Melbourne Cup the next week. But in the Cup, the favourite Dulcify found the legs another horse at a turn, broke his pelvis and was dead by nightfall.
"My wife never recovered from that," Hayes said. "She couldn't go back to the track.But the punt has got me pretty good."
Clarke says he has the strangest visits to the Legends paddocks, where people have come to tell him their own stories about the horses. In the 1997 Melbourne Cup, Greg Hall celebrated what he thought was a win when he crossed the line on Doriemus. A photo proved it was beaten by Might And Power.
"I had a guy come down to see Doriemus," Clarke said, "who'd put everything he had on the horse to win. This guy told me it was the best 30 seconds of his life when Greg Hall crossed the line. He'd paid off his mortgage. Then the photo came back, and so did his mortgage."
Clarke, a vet, travelled with Silent Witness all the way from Hong Kong to the farm in Melbourne. "We went right under the jet stream of a passenger plane and this horse did not blink. It was just so mentally strong."
Two men from Hong Kong came to visit the horse at the farm. They'd suffered some hard times up there, and they went to the track to cheer him on and feel better. He carried a legendary status in Hong Kong, and the men said they missed him. "They were crying while they patted him," Clarke said.


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According to this article in the People's Daily, the Fishery Department of the government of China has recommended banning the importation of the South American piranha (Serrasalmus spp.) and eradicating what is already in the country. The carnivorous fish, known as "fish-wolf" in China, was first introduced there in the mid-1980's, as an attraction in amusement parks. Piranha are now considered a threat to the country's freshwater ecosystems.
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Nelly Furtado took some time off after making her highly infectious 2006 album Loose. Well, she took some a break from making English-language albums, and instead, she dropped 2009's Spanish Mi Plan.
But this week's release, The Spirit Indestructible, finds Furtado planted somewhere in between pop vixen from 2006 and earthy songstress reminiscent of Mi Plan.
"This new album juxtaposes a lot of different things," she told MTV News about the release. "There's an innocence mixed with, like, a heaviness. There's sort of a playful energy with mixed with like a raw energy. It's a bit dark and light at the same time, just harder beats with playful vocals. So this album's very inspired: a lot of comes from my own life, life stories, experiences, even a lot of the themes are joy, celebration, nostalgia, novelty. [It] kind of runs the gamut. I think it's my most lyrically strong album to date as well."
Furtado has tried a bit of everything in the years since she dropped her debut album, Whoa, Nelly!, in 2000. She made a name for herself thanks to her folkie-influenced pop, but eventually stormed the charts as a dance-floor siren thanks to an assist from Timbaland on Loose. Now, 12 years into her career, she's willing to give it all a try, and it all makes up The Spirit Indestructible.
"I take this sort of buffet approach to making music," she said. "I just kind of want it all on every album. I think this album is sort of a combination of all my sounds. I think this new album is totally spiritual in this really not obvious kind of way. I love songs that make you move your body, but sort of have a deeper meaning to them."
And, she looked to a number of influences (see Odd Future for her single "Big Hoops (Bigger the Better)") and collaborators to help her craft her sound. That includes assists from Rodney Jerkins, Passion Pit leading man Michael Angelakos and producer Salaam Remi who helped make her Nas collaboration, "Something," happen.
"[Producer] Salaam Remi was a big part of this album," she recalled. "Him and I met during Mi Plan... He recorded three tracks for that and then near the end when I was just, like not even feeling like singing in English again, he was like, you know, trying to coax me back into it."
She continued, "He played me this beat and we did an English song, and we kept working together. And he's become a great friend and every girl or guy making pop records, sometimes when you love urban music, there's always room for a great hip-hop cameo. And I think everybody's first choice is always Nas, for many reasons. And Salaam, you know, works with him so much that he said 'Oh, no problem'."
From there, the tune, which she said highlights Nas' undeniable talent for making words mean something, was born. She added, "And he sent Nas the track, he loved it. It wasn't until I was finally sending in my liner notes to the label and handing in my lyrics that I had to ask Salaam for Nas' rap... It's one thing listening to Nas rap, but then when you see his words on paper, you really see what a poet he is. And I'm happy he's on the album."


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USB HiFi and HighEnd
It's simple and cheap to build your own audio computer that stores high-res files and sends these to a USB DAC. We highly recommend that you use a dedicated computer for digital music playback and audio files management, which you can then seamlessly integrate into your current audio equipment.
As far as performance goes, any current computers and processors can be used. You should pay particular attention to noise levels and basic network functionality, and choose your components accordingly. Following is a partial list with a description of the individual components for a home-built audio PC or music server which should help you in your purchasing selection.
|approx. Price
|Of course the case should look good and be small - but take care that it has the same form-factor as your motherboard (e.g. Mini-ITX) and that the power-supply is external and without fan..
|$ 100.00 - $ 200.00
|Mainboard & CPU
|We recommend mainboards with an integrated CPU ("CPU on board"). Intels Atom CPU based boards are highly recommended for best audiophile sound results. The motherboard should have stabilized voltage, form-factor Mini-ITX will be fine, take care that you can use them without a CPU-fan (fanless).
|$ 100.00
|Using a SSD-drive is expensive but you have no noise, using a SATA-drive will result in much storage for less money, and if you want to buy a nearly noiseless SATA-drive check out drives with lower speed (5,400 RPM).
|depending on SSD/SATA and disk-space
$ 50.00 - $ 250.00
|Memory / RAM
|The RAM depends on the chip of the motherboard - 2 GB (Linux based USB Music Server) - 4 GB (Windows / OSX) should be ok, but please be advised to use only good value RAM. The best is to operate the memory modules in "Dual-Channel Mode", the motherboard therefore is equipped with two identical RAM-modules.
|$ 40.00 - $ 100.00
|(No!) Fan
|There are a few mainboards with on board CPUs available (like the famous Intel Atom boards). But if you need a fan, buy a special "Low Noise Fan". And avoid internal power-supplys with fans or noisy case-fans.
|$ 10.00 - $ 50.00
|Noise Optimization
|If you have a case with an external power-supply, a SSD-drive and an onboard CPU without a fan you do not need noise optimization. But if not you can use a Low Noise Fan as described above and reduce noise and vibrations using sound deadening/damping mats (you can buy them at automotive acoustic shops) for SATA-drive and case.
|$ 15.00 - $ 30.00
|When you build in your motherboard in the case, juts take care not to enable the harddrive-LED - it could be extremely disturbing when the light flickers all the time.
|0.00 $


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Physicians affiliated with MultiCare are recognized as being among the best healthcare providers in the Northwest Region with both adult and pediatric specialists providing easy access for patient consultations right here in the community. You'll find everything you need to excel in your job including outstanding facilities, comprehensive resources and talented teammates sharing your commitment to quality patient care. MultiCare is a recognized leader in the use of advanced technology and EPIC, our Electronic Medical Record (EMR), keeps our staff better connected throughout the healthcare system. Whether you choose to affiliate with MultiCare through an employed position with one of our hospitals, clinics, a community practice or other contractual relationship our administrative team is here to partner with you t provide a high value system of health care.
• Board certified/eligible at time of employment
• Licensed in the state of WA by the time of employment
• DEA, NPI & prescriptive authority
• Current BLS for Healthcare Providers certification by the American Heart Association
MultiCare is an equal opportunity employer. Hiring decisions are made without regard to race, color, religion, national origin, sexual orientation, gender identity, disability or veteran status. EOE/AA/M/F/D/V
MultiCare is a smoke-free, drug-free workplace. All employment offers are contingent upon acceptable pre-employment drug tests which include testing for the use of marijuana and nicotine. As part of our commitment to a healthy workplace, we require employees to obtain an annual flu immunization.
If you are a job applicant who requires reasonable accommodation in the job application process, please contact our Candidate Experience Team at email@example.com.


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Skip to comments.Jury in John Edwards trial asks to see evidence exhibits
Posted on 05/21/2012 6:22:10 PM PDT by bkopto
The jury deciding the fate of John Edwards has asked to see more evidence exhibits.
The former presidential candidate faces 30 years in prison after pleading not guilty to six campaign finance corruption charges. The jury began considering its decision Friday, after nearly four weeks of testimony. Deliberations continued Monday morning. On Monday afternoon, the jurors asked to see eight evidence exhibits.
Prosecutors have accused the Democrat of masterminding a scheme to use nearly $1 million in secret payments from two donors to help hide his pregnant mistress as he sought the White House in 2008.
(Excerpt) Read more at ctv.ca ...
If you could get prison time for being a despicable piece of scum, Edwards would be looking at a lot more than 30 years.
It disturbs me that within the liberal community there is the feeling that any behavior is acceptable if it is their guy. But, in my heart, I want to believe that most conservatives would turn their backs on someone who acted as Edwards did, as Barney Frank did, as Maxine Waters did ... and on and on and on.
As long as this SOB is convicted of enough to have him disbarred, I'm kosher!
ya know, they are supposed to be serving the public. Send him to jail for as long as it takes to repay the public trust. It really amazes me that a dumocrat could do this. I am disillusioned. i will repent and vote for someone that has morals. i was infatuated with the hair. Silly me!
Sadly I think this snake will skate. I PRAY not.
Even better, donate once a month. Even better than better, join the Dollar a Day Club.
Not the John Edwards sex tape. Anything but the John Edwards sex tape.
Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.


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Product Spotlight
Featured Research
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C-Store Raided for Illegal Gambling Slots
Detroit police investigate Marathon franchisee, owner arrested.
Police raided a Marathon convenience store in Detroit yesterday after a tip about illegal gambling.
Police found video poker and video slots mixed in with other arcade games at the store, WDIV reported. All of the game slots were reportedly geared toward children. A clerk at the Schaefer Road store declined to comment on the situation to CSNews Online Officials at Findlay, Ohio-based Marathon Ashland Petroleum LLC were unavailable for comment.
An underage decoy walked in and played the machines and after receiving tips from parents, that was the last piece of evidence the deputies needed, the report said.
"We received some complaints from not only some patrons, but some parents saying that their youngsters would go in ... they would spend the money, and they in essence were gambling," Wayne County Sheriff Robert Ficano said, adding that one mother claimed that her son lost hundreds of dollars.
A store employee claimed that nobody under age had ever played the machines, the report said.
The machines were confiscated by the sheriff's department. The owner of the store was arrested with a high misdemeanor and faces up to two years in prison, Ficano said. At least two store employees were also ticketed. Ficano refused to release the names of the store owner or its employees.


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Would you like to save as your currency permanently or for this visit only?
Friendly staff and a quick check-in. Nice big bed and a reasonably spacious room. The price was the main factor, and it was the best deal in town. I'm not too picky, so I didn't mind it. The door had 3 locks (doorknob, deadbolt, and chain), but only the doorknob lock actually worked. The chain was missing, and the deadbolt wouldn't turn to lock. Ordinarily not too much of a problem, but I had my laptop in the room and felt very uneasy having to leave it there when we went out of the room for extended periods of time. It also caused some concern when "someone" came and knocked on our door at 1am. We didn't answer the door, and after a few knocks they went away, but it would have been nice to know that the door was more secure. A somewhat shady character who looked to be a long-term resident had approached us earlier asking for a cigarette, so it could have just been a "friendly local" looking to bum a smoke, but I didn't feel like getting out of bed to find out. The pool on property would have been nice if it was working, but it was empty and had a thick layer of bog slime in the bottom. We had a non-smoking room, but it had a very strong stale smoke odor. Also, the A/C struggled to keep the room cool; it was warm in there. None of these were dealbreakers to me, but I'm not too picky. If you are on a budget and are okay with a bit of run-down, you'll be fine.


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Met Art presents a fascinating collection of the most beautiful nude girls and their erotic pictures in the world. Tube Porn. You will not find filth or dirty sexual games at Met Art, but only beauty of a perfectly shaped teen body. These girls will still let you enjoy their bodies in every detail, but they will do in the special style peculiar to Met Art only.
I bet she feels as silky as she looks
Wow get marreid with me lolo


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Singing with Harmony will …. lift your spirits, help you unwind, help you find your voice
Singing with Harmony is …. joyful, harmonious, welcoming Check out
Check out Honest Mum Vicki's visit & video blog on behalf of Comic Relief
- Sing every Thursday 6-7.30 pm at the Anglers Club, 75 Stoney Rock Lane, Leeds,LS9 7TB
- Will help you find your voice if you haven't sung before
- Provide child-care so you don't have to stay at home because of the children – please contact us to book a place
- Welcome asylum seekers, who do not have to pay and can get help with bus fares
- Perform regularly for local events and community groups
- You pay £4 a week – or whatever you can afford
Check out our Facebook group
Thanks to our current funders
HealthAmaze is a Community Interest Company committed to raising money to address health inequalities in Wakefield and Leeds.
People's Health Trust is an independent charity addressing health inequalities across Great Britain. It works closely with each of the 51 society lotteries and makes grants using money raised by the society lotteries through The Health Lottery.


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Neurovascular Coupling in Patients With Open Angle Glaucoma
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
A variety of studies demonstrate that ocular blood flow is altered in glaucoma. Various animal and human studies have shown an increase in retinal and optic nerve head blood flow in response to diffuse luminance flicker. Based on studies with ERG, this effect has been attributed to augmented activity in the retinal ganglion cells and associated axons indicating a coupling mechanism between neuronal activity and retinal blood flow. Whereas a variety of studies have confirmed these effects, the knowledge about this coupling in the retina of patients with glaucoma is sparse.
Recently the investigators could show that flicker induced vasodilatation is blunted in patients with open angle glaucoma. However, the investigators results are limited by the fact that only data about retinal vessel diameters, not blood flow per se, are available. The further development of the investigators current flicker stimulation technique now allows us to determine blood flow velocity during flicker stimulation. Thus, in the current study, the investigators set out to determine whether this blood flow response is impaired in patients with glaucoma as compared to those in healthy volunteers and whether this is related to altered neural activity.
The study objective was, to investigate whether the blood flow response to flicker stimulation is altered in patients with glaucoma.
|Other: ocular blood flow measurements
|Study Type:
|Official Title:
|Neurovascular Coupling in Patients With Open Angle Glaucoma
- Retinal blood velocity (laser Doppler velocimetry) [ Time Frame: measurements done only once on the studyday ]
- Retinal arterial and venous diameter (Retinal vessel analyzer) [ Time Frame: measurements done only once on the studyday ]
- Optic nerve head blood flow (laser Doppler flowmetry) [ Time Frame: measurements done only once on the studyday ]
- Latency and amplitude (pattern ERG) [ Time Frame: measurements done only once on the studyday ]
- Mean arterial pressure [ Time Frame: measurements done only once on the studyday ]
|Estimated Enrollment:
|Study Start Date:
|October 2006
|Study Completion Date:
|May 2012
|Primary Completion Date:
|April 2007 (Final data collection date for primary outcome measure)
|Assigned Interventions
15 male and 15 female patients with glaucoma
Other: ocular blood flow measurements
non-invasive haemodynamic measurements of retinal vessel diameters, laser Doppler flowmetry and laser Doppler velocimetry
30 sex matched healthy volunteers
Other: ocular blood flow measurements
non-invasive haemodynamic measurements of retinal vessel diameters, laser Doppler flowmetry and laser Doppler velocimetry
|Ages Eligible for Study:
|18 Years to 80 Years (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Men and women aged between 20 and 80 years.
- Normal findings in the medical history and physical examination unless the investigator considers an abnormality to be clinically irrelevant.
- Inclusion criteria of patients are open angle glaucoma.
- Men and women will be included in equal parts. A pregnancy test will be performed at screening.
- Ametropia of less than 3 diopters and anisometropia of less than 1 diopter.
Exclusion Criteria:
- Treatment with vasoactive drugs.
- Presence of intraocular pathology other than open angle glaucoma.
- Presence of ocular hypertension or PEX (pseudoexfoliation) glaucoma
- History or family history of epilepsy.
- Pregnancy.
- Diabetes mellitus.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00811694
|Department of Clinical Pharmacology, Meical University of Vienna, Austria
|Vienna, Austria, 1090
|Principal Investigator:
|Gabriele Fuchsjäger Mayrl, MD
|Department of Clinical Pharmacology, Meical University of Vienna
|Responsible Party:
|Gabriele Fuchsjäger Mayrl, MD, Department of Clinical Pharmacology, Medical University of Vienna , Austria
|ClinicalTrials.gov Identifier:
|NCT00811694 History of Changes
|Other Study ID Numbers:
|Study First Received:
|July 2, 2008
|Last Updated:
|November 20, 2014
Keywords provided by Medical University of Vienna:
ficker stimulation
ocular blood flow
Additional relevant MeSH terms:
Glaucoma, Open-Angle
Ocular Hypertension
Eye Diseases
ClinicalTrials.gov processed this record on July 21, 2017


text: Draghi said countries reformed to help themselves, not to satisfy the ECB or European Commission."For this reason, it is wrong to claim that countries are undertaking reforms only to please the markets or to satisfy the demands of technocrats in Brussels, Frankfurt or Washington. They are doing it for their own benefit. And it is time that this message gets more emphasis." The Commission, which is the European Union's executive commission, and Germany, the eurozone's biggest member, have pushed for balanced budgets as a major part of the solution to Europe's crisis over too much government debt. They've done so over the objections of some economists and leaders who argue that cutting spending reduces growth and ultimately makes debt harder to pay. Eurozone leaders' strategy also includes reforms to make troubled countries better places to do business and efforts to steady a troubled banking system.


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Choice Movie Actress: Action Adventure
Cate Blanchett, "Robin Hood" Mila Kunis, "The Book of Eli" Rachel McAdams, "Sherlock Holmes" Sienna Miller, "G.I. Joe: The Rise of Cobra" Zo¿¿ Saldana, "The Losers"
Warner Bros.
Copyright © 2017, Daily Press
- Robin Hood (movie, 2010)
- Rachel McAdams
- Sienna Miller
- G.I. Joe: The Rise of Cobra (movie)
- The Book of Eli (movie)
- Cate Blanchett
- Mila Kunis


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RepairPal is your advocate for car care advice and guidance
Q: Gurgling sound on 2007 Lincoln Town Car
I have a gurgle under dash on passenger side. Dealership said thet could fix it and ordered part. When I picked the car up they said it can't be fixed and that it is normal for that car. I actually think it's worse now than when I took it in.
its your heater modulus, i had the same problem. Tell them to replace both L & R side.
Generally a gurgling sound from your dashboard area is caused by bubbles or air getting in to your coolant which can be heard from your heater core. Does your car use any coolant? Does it ever run too warm? Check the reservoir and make sure. If it does use or leak coolant , is your car still within warranty, that is, is it past the 3 yr/36,000 mile range? Bubbles in your coolant can be a troubling situation, in that there could be a leaking gasket in your engine, either a head gasket or intake manifold gasket etc. I would stay on this situation until it is fully resolved.
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Getting spaghetti bolognese out of cream carpet(3 Posts)
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Compact Foldable Laptop Design Does Not Fold into Half But into Thirds
Laptops, the portable form of the desktop computer as we know have always come in two sections. One half of which is the screen where the other half made of up physical input interfaces such as keyboards and trackpads. However, this compact foldable laptop design goes against the look and shape of conventional laptops with the ability to fold itself not into two halves but into thirds!
The unique-looking triple-folding laptop design called Feno was conceived by designer Neils van Hoof from the Netherlands. While two-thirds of the laptop make up the screen, only one third of the laptop is reserved for an input device, in this case an adequately sized QWERTY keyboard.
Interestingly enough the laptop in its folded state is still capable of containing an internal optical drive, though having it removed in favor of external or cloud storage would be a better idea which will free up some physical space for more powerful core components.
With the advancement in technology of flexible displays in this time and age, this concept of a laptop with a foldable screen is definitely not far from reality. Perhaps we'll even have lightweight and compact touchscreen tablets that fold neatly into a shirt pocket in time to come.


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Let us know when your receive great advice so we can thank our lawyers and point others with similar questions in the right direction.Got it!
families of victims be allowed to decide the punishment of those who commit crimes
Is this a philosophical question or are you asking if this is how it works in our system. Well the answer is victims do not decide the terms of punishment one receives. A victim is able to address the court and give a victim impact statement but the truth is by the time a victim gives that statement the sentence has already been agreed upon by the judge and the prosecutor. Most crimes have a standard range and the facts of the case will determine where the sentence falls on that range.
Robert Driessen
Generally, victims do not decide the punishment that a convicted defendant receives.
However, some District Attorneys consult with a victim and his or her family. This consultation may be to let the victim and other know the prosecution's view of the case and what the possible out come may be. The consultation may also be to see what the victim and family want to happen to the defendant if convicted. The consultation with the victim and family may be to discuss a resolution the DA would propose to save the family the trauma of trial. If the case is one where the prosecution is seeking the death penalty, family members are frequently called as witnesses for the prosecution.
So, the bottom line answer is that victims and their family members do not choose the punishment; but, depending on events in specific cases, may have an input as to what a sentence should be.
It is understandable that a victim's family would want to determine what happens to a perpetrator.
However, we live in a society where the punishment for crimes is determined by law. Judges can consider the impact of a crime on the family, but they are also required to impose sentences that are fair and consistent with the law.Ask a similar question
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It only takes a minute to get started. Fill out our simple sign up form and login to the site.
This step is voluntary but will seriously raise your chances of getting interest from other Christian members on the site. Tell people about yourself, your hobbies and attach any nice photographs of yourself.
Utilise our website's advanced search to discover members who meet your criteria. Or just browse through listings of Christian singles and discover members that appear interesting.
Discovered someone who meets your requirements? Drop them a line or just a wink and see what happens next. With a little luck you'll be on your way to a lifetime of happiness.
It'll only take 30 seconds