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The effect of an intracerebroventricular injection of metformin or AICAR on the plasma concentrations of melatonin in the ewe: potential involvement of AMPK?
It is now widely accepted that AMP-activated protein kinase (AMPK) is a critical regulator of energy homeostasis. Recently, it has been shown to regulate circadian clocks. In seasonal breeding species such as sheep, the circadian clock controls the secretion of an endogenous rhythm of melatonin and, as a consequence, is probably involved in the generation of seasonal rhythms of reproduction. Considering this, we identified the presence of the subunits of AMPK in different hypothalamic nuclei involved in the pre- and post-pineal pathways that control seasonality of reproduction in the ewe and we investigated if the intracerebroventricular (i.c.v.) injection of two activators of AMPK, metformin and AICAR, affected the circadian rhythm of melatonin in ewes that were housed in constant darkness. In parallel the secretion of insulin was monitored as a peripheral metabolic marker. We also investigated the effects of i.c.v. AICAR on the phosphorylation of AMPK and acetyl-CoA carboxylase (ACC), a downstream target of AMPK, in brain structures along the photoneuroendocrine pathway to the pineal gland.
All the subunits of AMPK that we studied were identified in all brain areas that were dissected but with some differences in their level of expression among structures. Metformin and AICAR both reduced (p < 0.001 and p < 0.01 respectively) the amplitude of the circadian rhythm of melatonin secretion independently of insulin secretion. The i.c.v. injection of AICAR only tended (p = 0.1) to increase the levels of phosphorylated AMPK in the paraventricular nucleus but significantly increased the levels of phosphorylated ACC in the paraventricular nucleus (p < 0.001) and in the pineal gland (p < 0.05).
Taken together, these results suggest a potential role for AMPK on the secretion of melatonin probably acting trough the paraventricular nucleus and/or directly in the pineal gland. We conclude that AMPK may act as a metabolic cue to modulate the rhythm of melatonin secretion.
The serine-threonine kinase, AMPK integrates energy homeostasis at both cellular
Hormones and reagents
The metformin and AICAR used for the i.c.v. injections were obtained from Sigma (Saint Quentin Fallavier, France). The dose injected by means of an intracerebroventricular catheter, was 128 mM for metformin (adapted to sheep from
Rabbit polyclonal antibodies to phospho-AMPKα Thr172, AMPKα1/2, AMPKβ1/β2, AMPKγ2, phospho-acetyl-CoA carboxylase (ACC) Ser79 and ACC were purchased from New England Biolabs Inc. (Beverly, MA, USA). A mouse monoclonal antibody to vinculin was obtained from Sigma (Saint Quentin Fallavier, France) and used as an internal standard.
Animals and experimental designs
Nineteen multiparous ewes were surgically fitted with cannulae in the anterodorsal region of their third ventricles
In the first experiment, two groups of ewes (G1, G2, n = 4) balanced for body condition score and live weight were used in a cross-over design so that each group received in random order 9 days apart (day 0 or D0 and D10), either artificial CSF or metformin. Forty days later, groups were re-balanced for their night-time plasma concentrations of melatonin (G3, G4, n = 4), and the experiment was repeated using AICAR with the same cross-over design (D42 and D52) (Figure
Figure 1
Experimental design for the first experiment
Experimental design for the first experiment. (A) Schematic representation of the cross-over experimental design. Photoperiodic treatments are given in the upper part. 3 weeks before the first day of injection (D0) the ewes were housed under LP. During each day of injection (D0 and D10 for metformin; D42 and D52 for AICAR) LP was replaced by DD. (B) Bleeding protocol operated during DD, each thick depicts one sample. Thick arrow depict the clock time for the administration of the injection (19:00). Serial sampling period began 1 hr before injection and lasted for 7 hrs (from 17:00 to 00:00 during the injection of metformin and adjusted from 18:00 to 01:00 for the injection of AICAR). Thin arrows depict theoretical lightning transitions. See text for more details.
For the second experiment, two groups of ewes balanced as for experiment 1, were injected with either AICAR (n = 6) or artificial CSF (n = 5). One hour after injection the animals were slaughtered by decapitation, the brain was removed quickly and frozen in isopentane (SDS, Val De Rueil, France). The pituitary (PIT) and pineal (PIN) glands were immediately dissected, frozen in liquid nitrogen and stored at -80°C. Frontal sections (1 mm thick) were sliced from the diencephalon and other structures of interest were dissected using a sterile scalpel, all were frozen in liquid nitrogen and stored at -80°C. The hypothalamic structures of interest (suprachiasmatic nucleus [SCN], arcuate nucleus [ARC], median eminence [ME], paraventricular nucleus [PVN], dorsomedial hypothalamic nucleus [DMH], tanycytes [TAN] and premammilary hypothalamic nucleus [PMH]) were identified using sheep brain atlases
All these procedures were approved by the French Agricultural and Scientific Research Agencies and conducted in accordance with the EU guidelines for Care and Use of Agricultural Animals in Agricultural Research and Teaching.
Western-blotting procedures were conducted as previously described
Melatonin was assayed using a radioimmunoassay (RIA) described by Fraser
Data and Statistical analysis
Melatonin profiles were analysed by comparing the timing of resumption and the amplitude, of the circadian rhythm of melatonin secretion. These criteria were determined using the method of Malpaux
The amplitude of the endogenous rhythm of melatonin was reduced significantly by both metformin (p < 0.001) and AICAR (p < 0.01) (Figure
Figure 2
The monitoring of the endogenous rhythm of secretion of melatonin
The monitoring of the endogenous rhythm of secretion of melatonin. The data show the concentration of plasma melatonin for each group separately (G1 to G4). Animals were housed in constant darkness and given an i.c.v. injection of either metformin (G1 & G2; open triangle) or AICAR (G3 & G4; open square) or artificial CSF as a control vehicle (closed circle). Injections were performed nine days apart and in a random order for each group (see text and Figure 1 for more details about the order of injection for each group). The arrows depict the time of injection and shaded area corresponds to the period of increased sampling frequency. Note the log-scale y-axis.
Figure 3
The monitoring of the secretion of plasma insulin
The monitoring of the secretion of plasma insulin. The data show the concentration of plasma insulin in two groups of ewes housed in constant darkness and given an i.c.v. injection of either (A) metformin or (B) AICAR (open circle) or a synthetic CSF as a control vehicle (closed circle). The arrows depict the time of injection.
The results of experiment 2 show that the expression levels of the AMPK subunits (Figure
Figure 4
Western-blotting quantification of the AMPK subunits α, β1, β2 and γ2 in pituitary gland (PIT), median eminence (ME), arcuate nucleus (ARC), dorsomedial and premammilary hypothalamus (DMH, PMH), tanycytes (TAN), pineal gland (PIN) and paraventricular and suprachiasmatic nuclei (PVN, SCN) of the sheep brain
Western-blotting quantification of the AMPK subunits α, β1, β2 and γ2 in pituitary gland (PIT), median eminence (ME), arcuate nucleus (ARC), dorsomedial and premammilary hypothalamus (DMH, PMH), tanycytes (TAN), pineal gland (PIN) and paraventricular and suprachiasmatic nuclei (PVN, SCN) of the sheep brain. Different letters indicate a stastistically significant difference (p < 0.05).
Figure 5
Western-blotting quantification of the phosphorylation rate of AMPK and ACC after i.c.v. injection of AICAR
Western-blotting quantification of the phosphorylation rate of AMPK and ACC after i.c.v. injection of AICAR. (A) The ratio of phosphorylated AMPK at Thr172 to total AMPK following an i.c.v. injection of a synthetic CSF vehicle or AICAR. (B) The ratio of phosphorylated ACC at Ser79 to total ACC following an i.c.v. injection of a synthetic CSF vehicle or AICAR.
The hypothesis tested in this study, developed from the findings of Um et al.
There are three main possibilities to account for the rejection of our hypothesis. First, the i.c.v. treatment with either metformin or AICAR was ineffective and did not stimulate AMPK in the hypothalamic structures we examined. Indeed, the similarities of the effects between the i.c.v. injections of both drugs on the amplitude of the rhythm of melatonin secretion suggest that they might be mediated by the activation of AMPK, as a common element along their distinct signalling pathways
The biological relevance of the lowering effects of both metformin and AICAR on the amplitude of the endogenous rhythm of melatonin is difficult to interpret. Indeed, in sheep as in most photoperiodic species, the duration of melatonin secretion is the critical feature of the rhythm of melatonin secretion that transmits photoperiodic information to the reproductive axis
The effect of metformin and AICAR on the amplitude of the rhythm of melatonin secretion was not associated with immediate changes in insulin secretion and thus, was not attributable to the interrelationship that exists between these two hormones
The characterization of the expression of AMPK within the hypothalamus, pituitary and pineal glands of the ewes suggests a potentially wide range of action for metformin and AICAR since all subunits were identified in each of the structures that we examined. The differences among structures in the level of expression of the β2 and γ2 subunits may indicate structural specificities in the sensitivity or functionality of the AMPK complex
In this experiment, the failure to demonstrate significant direct activation of the AMPK complex following treatment with AICAR might be explained by the time elapsed between tissue fixation and injection (1 hr) and the possible action of endogenous phosphatases
To conclude, the i.c.v. administration of AMPK-activators had an unexpected insulin-independent effect on the amplitude of the endogenous rhythm of secretion of melatonin that retrospectively, might have also been observed in natural photoperiodic conditions, on the daily pattern of melatonin secretion. This effect probably involves the AMPK system trough the paraventricular nucleus and/or directly within the pineal gland. This mechanism remains to be precisely determined but we suggest that it involves the integration of metabolic-related cues with the photoperiodic signal that synchronizes the annual rhythm of reproduction in sheep.
Competing interests
The authors declare that they have no competing interests.
Authors' contributions
The authors contributed equally to this study. JBM conceived the study, carried out the experiment, collected data, and drafted the manuscript. CT collected data and performed the melatonin assays. AC and DC followed the experiment and performed melatonin assays. DL performed the injection of drugs and blood sampling. JD, BM and RJS designed the study. JBM, CT, JD, BM and RJS were involved in the analysis and interpretation of the data. JBM and JD revised the manuscript. All authors read and approved the final manuscript.
The authors would like to acknowledge Dr Laurence Dufourny for her help with brain dissections as Dr Jean-Claude Thiéry for his help in pre-experimental studies. Dr Sébastien Elis and Christelle Ramé are acknowledged for their technical help. The authors also thank the staff of the experimental unit of INRA Centre de Tours (UEPAO) for the care provided to the animals, as well as the staff of the Experimental Hospital (PRC) for surgical procedures. RJS was the recipient of an EU Marie Curie Chair of Excellence (MEXC-CT-2006-042499) and JBM a PhD grant from the "Ministère de l'Enseignement Supérieur et de la Recherche".
AMP-activated protein kinase plays a role in the control of food intake
AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism
Management of cellular energy by the AMP-activated protein kinase system
Role of AMP-activated protein kinase in mechanism of metformin action
5-aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells?
The effect of AMP-activated kinase activation on gonadotrophin-releasing hormone secretion in GT1-7 cells and its potential role in hypothalamic regulation of the oestrous cyclicity in rats
AMP-activated protein kinase signaling in metabolic regulation
AMPK: a link between metabolism and reproduction?
Seasonal regulation of reproduction in mammals
Activation of 5'-AMP-activated kinase with diabetes drug metformin induces casein kinase Iepsilon (CKIepsilon)-dependent degradation of clock protein mPer2
The effect of melatonin on insulin secretion in rat and mouse
Melatonin inhibition of insulin secretion in the rat and mouse
AMP-activated protein kinase is activated by low glucose in cell lines derived from pancreatic beta cells, and may regulate insulin release
Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state
Turnover rate of cerebrospinal fluid in female sheep: changes related to different light-dark cycles
The brain of the sheep
Direct radioimmunoassay for melatonin in plasma
[Conditions for the use of specific antibodies for immunohistochemical visualization of serotonin and melatonin in the pineal gland of sheep]
Termination of the breeding season in the Suffolk ewe: involvement of an endogenous rhythm of reproduction
R: A language and environment for statistical computing
The Anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways
5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside and metformin inhibit hepatic glucose phosphorylation by an AMP-activated protein kinase-independent effect on glucokinase translocation
Plasma melatonin profiles of Romney Marsh sheep in natural photoperiod and in acutely extended darkness
Synchronization of the molecular clockwork by light- and food-related cues in mammals
How does melatonin code for day length in the ewe: duration of nocturnal melatonin release or coincidence of melatonin with a light-entrained sensitive period?
Environmental control of the seasonal variations in the daily pattern of melatonin synthesis in the European hamster, Cricetus cricetus
Mechanisms regulating the marked seasonal variation in melatonin synthesis in the European hamster pineal gland
Amplitude of the plasma melatonin nycthemeral rhythms is not associated with the dates of onset and offset of the seasonal ovulatory activity in the Ile-de-France ewe
Seasonal variations in the amplitude of the daily pattern of melatonin secretion in mammalian and non-mammalian vertebrates: Possible physiological consequences
Seasonal changes in oestrus activity and ovulation rate in Rasa Aragonesa ewes maintained at two different body condition levels
Generation of the melatonin endocrine message in mammals: a review of the complex regulation of melatonin synthesis by norepinephrine, peptides, and other pineal transmitters
AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons
Role of the pineal gland and melatonin in the development of autoimmune diabetes in non-obese diabetic mice
Melatonin and type 2 diabetes - a possible link?
Diabetic Goto Kakizaki rats as well as type 2 diabetic patients show a decreased diurnal serum melatonin level and an increased pancreatic melatonin-receptor status
A common bicyclic protein kinase cascade inactivates the regulatory enzymes of fatty acid and cholesterol biosynthesis
Phosphorylation-activity relationships of AMPK and acetyl-CoA carboxylase in muscle
Ppm1E is an


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NPD: C-Stores Sell 7 Percent of Ready-to-Eat Foods
Evening snacks account for most of the purchases.
CHICAGO -- Seven percent of the roughly 62 billion commercial foodservice meals and snacks consumed annually are purchased at convenience stores, with retail stores—food, drug, discount, department and price clubs—representing an additional 6 percent, according to a new report from the NPD Group, based here.
Retail foodservice represents spending of close to $13 billion, according to NPD's recently released "Retail Meal Solutions" report. Retail ready-to-eat meal and snack purchases increased 2 percent for the year ending August 2008. The quick-service restaurant (QSR) segment, with which retail stores directly compete in providing convenience meal solutions, saw sales grow by only 1 percent. The full-service restaurant segment realized a downturn.
"Consumers' increasing use of foodservice for ready-made meals has long been recognized by grocery retailers as an opportunity," Bonnie Riggs, NPD restaurant industry analyst and author of the report, said in a statement. "For some time, retail stores have offered prepared foods in the deli department, but have now expanded foodservice offerings to include a variety of cold and hot ready-to-consume meals and snacks."
The report dispels the popularly held belief that supper is the prime daypart for retail meal and snack solutions. NPD found supper accounted for only 17 percent of retail meal solutions consumed, though it is a steadily growing daypart for retailers. It is a weakening daypart for QSRs. Evening snacks represent the largest share, 35 percent, of ready-to-eat food consumed, followed by lunch with a 27 percent share, and the morning meal, with a 21 percent share.
"Retail outlets are more dependent on morning meals and p.m. snack purchases than QSRs," said Riggs. "These are the on-the-go needs that are being met by retailers—consumers making those purchases on the way to work, to eat at work, or in their car; purchases that otherwise would have been made at a QSR."
Consumer motivation in purchasing prepared meals and snacks from retail stores include convenience, availability of healthier options, variety and affordability, according to the report. Riggs said these are the attributes consumers found lacking at QSRs.
"As always, it's a matter of learning and understanding consumers' needs when it comes to meal and snack solutions," she said. "With this learning and understanding, there is opportunity here for retailers, foodservice manufacturers and restaurant operators."


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Where there is generosity, there is warmth.
The maxim rang true Tuesday for hundreds of senior citizens served by the St. Mary Parish Council on Aging, which began distributing more than 700 donated blankets to home-bound residents after a weeks-long drive.
"Oh, we are gonna have some people who are gonna be so excited!" said Beverly Domengeaux, the council's 80-year-old executive director for more than a decade. "Everybody in St. Mary Parish has really pitched in."
Domengeaux, along with her five-member staff, 11-member board and their spouses, distributed 250 of the new, used and handmade blankets Tuesday. Another 250 are set for dispersal Monday, and the remaining 200 — a number above the council's 500-blanket goal — will be stowed for future donations, Domengeaux said.
Thibodaux resident Jackie Boudreaux, 67, said she spends her free time crocheting at home while watching TV. She made the 30-mile trip to Berwick to see relatives and to donate six of her handmade afghans toward the drive.
"I saw an ad and said, 'Well, that would be nice,' " Boudreaux recalled. "So I made the trip."
The St. Mary Parish Sheriff's Office led the drive and took in 206 blankets on its own. It also took in two pallets of used blankets from G&J Land and Marine Food Distributors Inc. and 10 new blankets from Walgreens.
"The community outdid itself in giving and donation," Sheriff's Office spokeswoman Traci Landry said.
Donations are especially important for the Council on Aging's success, as federal and state funding cuts have forced Domengeaux to cut corners for her operation, she said. The council functions on an annual budget of about $519,000 and relies largely on grants and private donations to continue caring for the elderly.
"They feel like they're the forgotten people," Domengeaux said. "But we've got to remember that if it wasn't for them, none of us would be here."
In addition to the year-round serving of just over 200 hot meals daily to home-bound seniors in the parish, Domengeaux said, the council also delivered close to 500 nonperishable food baskets this month ahead of Christmas. She expects to deliver another 500 by New Year's Day.
"We think this is one of the best years that we've ever had, and I know it's one of the happiest holiday seasons that a lot of our seniors have had," Domengeaux said.
More than 10,600 St. Mary Parish residents are older than 60, and 80 percent of them live alone, Domengeaux said. And the parish's elderly population is growing as quickly as its youth population dwindles.
"That leaves a lot of seniors here without any family," Domengeaux said.
To fill the void, the council distributes food like small cereal boxes, snack foods and microwavable dinners, which makes cooking and eating easier for aging residents who are hesitant to surrender their independence. Drivers are also available to bring them around town, whether for doctor's visits, shopping trips or dining out.
"They're proud people. They don't want to ask for any help," Domengeaux said. "But we try to treat them very special."
Follow Lanie Lee Cook on Twitter, @lanieleecook, or contact her by phone at (337) 534-0825.


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As I grow older I'm starting to know the attitude I have, type of things I want/to do and my priorities in my life ..
While other people is so busy to become rich and successful all I wanted to do is to be happy and to help people, before my birthday which is last month I asked my mama if I can go back Philippines cause I want to donate stuff and feed homeless people on my birthday instead of buying things for myself and treat my friends to eat outside, I find it better than wasting for alcohol and sh*t. But as usual they didn't allow me I never travel alone, neither with friends.
When I was in Phillippines I used to see people doing bad behaviour in front me yet I don't react and just let things happen like people in market try to touch my ass, Drivers cat calling me, annoying jeep passengers who will ask me to give to the manong their bayad while I'm fucking far from the driver, mean girls who look at me one kind, Taxi Drivers who will bring me in a longer way, manicuristang ate try to murder my nails and too many to mention. I'm scared to tell them to stop doing this and that, I'm scared to say I know what you're doing you better stop it now, as in right now. BUT NOW? Fuck yea! I told the lady who's drinking milk tea inside the train that she shouldn't drink inside there and point to the pictures of things you shouldn't do inside the train, to the taxi driver to stop bringing me to longer way because I know the place, to the police I raised my middle finger after cat calling me and to the Chinese lady behind me while watching dead pool movie to stop kicking the chair because it's fucking annoying.. I wasn't a bad person after all :))


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by Staff Writers
Beijing, China (AFP) July 05, 2013
Chinese authorities imposed tight control in the capital of Xinjiang on Friday, the fourth anniversary of ethnic rioting which killed around 200 people, said state media, exile groups and ordinary citizens.
Internet users posted pictures of baton-wielding security personnel in Urumqi, a city of more than two million people and the scene of clashes in 2009 between mostly Muslim Uighurs and members of China's Han majority that were Xinjiang's worst violence of recent years.
Last week two incidents in the region left at least 35 people dead and officials have vowed to crack down on what they call "terrorists".
"Wearing helmets, officers patrolled the capital holding guns and shields," said the state-run Global Times newspaper, describing the "heaviest security measures since 2009" in Urumqi.
There was "a heavy presence of armed police officers and police vehicles at all major crossroads in Urumqi", it added.
China commonly steps up patrols for the July 5 anniversary of the riots but the report said: "Last week's violence in the region has made authorities particularly watchful."
The date also comes in the run-up to the Islamic holy month of Ramadan.
Numerous police cars patrolled Urumqi's streets and helicopters flew overhead, a city resident surnamed Wang told AFP on Friday via an online chat service.
"I haven't heard or seen any conflicts occur, and all shops and businesses seem to be running as normal," he said.
"The Urumqi train station feels safe," a user of Sina Weibo, a Twitter-like microblogging service, posted Thursday under the name Zhangxh1970. "On the square there are only police. People who came to pick up passengers are stopped outside."
"Harmonious Xinjiang," he added, an apparent dig at the pacific image of the region often depicted in state propaganda.
That theme was highlighted on Friday evening's main national TV news broadcast, which carried segments on Xinjiang including images of dancing people in ethnic dress.
Xinjiang's population is 46 percent Uighur with 39 percent Han, who largely dominate the economy and are a majority in Urumqi.
Uighur organisations accuse Beijing of suppressing their language, culture and religion, while China says development of the resource-rich region has raised living standards.
"Despite what the West thinks about China, Beijing has for decades channelled money, technology and talent into developing Xinjiang, while respecting the culture, language and religion of its ethnic minorities," the official Xinhua news agency said Friday in a commentary.
Dilxat Raxit, spokesman for the Munich-based World Uyghur Congress WUC), said in an e-mail: "China is launching a coercion policy against Uighurs to forbid them from assembling and mosques from holding prayer ceremonies for Uighurs that died in the 7.5 incident in 2009."
"Uighurs don't feel safe even in their own homes," he added. "They have to face discriminative inspections and provocations everyday and new conflicts can be triggered anytime, anywhere."
The WUC released a report Friday claiming that at least 102 people have died in violence in Xinjiang since March, citing reports by media and Chinese authorities, though added its own sources in the region suggest the toll is substantially higher.
At the weekend, China staged a show of force in Urumqi, with armoured personnel carriers and at least 1,000 armed personnel blocking access to streets with large sections of the city centre shut down.
Yu Zhengsheng, a member of the ruling Communist party's top Politburo Standing Committee, said that China would "step up actions to crack down upon terrorist groups", while Meng Jianzhu, another senior official, called for "24-hour patrols".
State media have adopted the "terrorism" label as a key theme in recent days.
Friday's Xinhua commentary said "terror attacks" are not about religion or ethnicity but rather separatism.
"Those who want to separate China and pursue selfish goals will find any excuse to wield their knives on innocent people and set cars and buildings ablaze," it said.
The China Daily carried a lengthy front-page article Friday on last week's violence in Lukqun, where 35 people were reported killed, based on interviews with witnesses, victims and relatives of the dead.
"I can't describe how much I hate them (the attackers)," the paper quoted Adalathan Yiminiaz, the widow of a hotel owner who was killed. "My family is destroyed and I cannot see any future."
China's foreign ministry spokeswoman Hua Chunying said that Beijing had "a very clear definition" of the 2009 events.
"It was an organised, serious and violent crime involving smashing, burning and looting which was plotted by terrorists in and outside China and carried out by terrorists in China," she said.
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Columns 3 - Revenge of Columns
Platform: Genesis
See also: Puzzle Games, Columns Games
- Manufacturer: Mega Drive
- Machine: Sega of America
In pursuit to create the next "Tetris", Sega of Japan has improved upon their popular game Columns for great results. First off, you will see the graphics have improved tremendously, and secondly, up to five players can compete at once. Imagine the intensity and fun of five friends taking out their frustrations on one another! It's great; if you love action puzzlers, this hits the mark.
Similar Games
In this fun-filled action-fest, you'll be up against some of your favorite villains from the Adventures of Sonic the Hedgehog television series.
A combination of Pac-Man and Tetris, Pac-Attack mixes the ghost-gobbling action of the former with the falling block puzzle aspects of the latter.
Columns 3 - Revenge of Columns DownloadsColumns 3 - Revenge of Columns download
Columns 3 - Revenge of Columns has long been regarded as the nemesis of Tetris. Arrange the falling jewels to form a horizontal, vertical, or diagonal group of three of the same color.
Columns 3 - Revenge of Columns is a third game in the Columns series. In this fast-paced puzzle mayhem, your goal is to arrange three or more jewels of the same colour horizontally, vertically or diagonally to remove them from the playing screen. While the jewels are falling, you can change the order of their colours.
In the Arcade, Versus, and Time Trial modes, you can test your skills against an opponent, a clock, or a specific task such as removing a particular jewel. New features include a rising bar that can be used to annoy opponents and magical items that have strategic value to alter the outcome mid-game.


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Collecting Stem Cells in Patients With Waldenstrom's Macroglobulinemia
The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified January 2008 by National Cancer Institute (NCI).
Recruitment status was: Recruiting
Recruitment status was: Recruiting
Herbert Irving Comprehensive Cancer Center
National Cancer Institute (NCI)
Information provided by:
National Cancer Institute (NCI)
ClinicalTrials.gov Identifier:
First received: May 9, 2009
Last updated: December 17, 2013
Last verified: January 2008
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
No Study Results Posted on ClinicalTrials.gov for this Study
|Study Status:
|This study is currently recruiting participants.
|Study Completion Date:
|No date given
|Primary Completion Date:
|No date given


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Did you know it's a snap to imbed video in a Word 2013 document? Let me show you how it's done. Click the Insert tab at the top of the document.
Then pick Online Video.
You can then search Bing or YouTube for the video or paste an imbed code. The video will then display in the document. The reader can view simply by clicking the play button.
~ Cynthia
Tags: imbed online videos, microsoft office, office, word 2013


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Lil Yachty keeps it moving with new music in the way of "So Many People". This joint was dropped by Zane Lowe on his Beats 1 radio show so you know its real right now incase you been sleeping on Yachty. Stream it after the jump
Tag: so many people
Total 1 Post


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I know a while back there were actually quite a bit of Russians who used Chinese characters as their names. I remember seeing the names then checking their profiles to see Russian flags and comments on it. I think they were trying to avoid people getting angry at them for being Russians.
You are not allowed to request a sticky.


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You'll be amazed at how just few quick steps will make you start earning from your blog! Here's how:
Share with TripHobo user your passion for travel. Make your profile look credible and get more followers through TripHobo
You look great! Upload a pic. It's essential.
Your dashboard will show you 'Get Code' tab with two widgets under it i.e
Banner-Create Trip Plans Widget and Trip Plans Widget.
Enter the URL of the blog post
You are all set to start earning! Sign Up Now


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It really was my intention to not blog again before the end of the year, but I couldn't wait that long to share news about these new tag-based features at LibWorm that Frankie has been working hard on.
First is that if any individual search result has tags, LibWorm finds the tags and shows 'em to you in the search results:
That's not the coolest part- we're just getting started.
Because LibWorm is looking for tags, tags are also included on every search. So if, for instance, I search for "ALA". LibWorm will notice that Meredith Farkas used "ALA" as a tag on her post from 12/8/06, Living my 9th Grade Dream:
Above: The "ALA" is bolded to show us that the tag is where LibWorm found the keyword.
But that's not the coolest part, either.
Frankie also used the tag data from LibWorm to build Tag Clouds.
There are two options, the Small Cloud and the Large Cloud.
(Frequency of a tag's use has to be higher to be in the small cloud.)
But that's still not the coolest part.
If you click a tag in the tag cloud, LibWorm will show you all the posts it has indexed that use that tag, and will enable you to subscribe to a feed based on that tag.
Yeah, that's the coolest part. 🙂
As always, please let us know what you think!
-David Rothman
President, Frankie Dolan Fan Club
(U.S. Chapter)


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Browse Titles by Subject
- Biomedical Engineering
- Chemical Engineering
- Civil Engineering and Geomechanics
- Cognitive Science
- Computer Engineering
- Digital Signal and Image Processing
- Earth Systems Environmental Sciences
- Ecological Science
- Electrical Engineering
- Electronics Engineering
- Energy
- Fluid Mechanics
- Food Science and Technology
- Health Engineering and Society
- Information Systems, Web and Pervasive Computing
- Innovation, Entrepreneurship and Management
- Materials Science
- Mathematics and Statistics
- Mechanical Engineering and Solid Mechanics
- Molecular, Green, Medical and Pharma. Chemistry
- Nanoscience and Nanotechnology
- Networks & Telecommunications
- Numerical Methods in Engineering
- Science, Society and New Technologies
- Space Science and Technology
- Systems and Industrial Engineering Robotics
- Waves and Applied Physics
Molecular, Green, Medical and Pharma. Chemistry
Psychotropic Drugs, Prevention and Harm Reduction
Addictions Set
This book promotes the interaction between research and professional practices in the field of prevention and harm reduction. Through the scientific work and experience of human and social sciences researchers and medical social actors, research and action assist one another in illuminating the problems associated with the consumption of psychotropic drugs and in developing intervention strategies...
Radical and Ion-pairing Strategies in Asymmetric Organocatalysis
Green Chemistry and Organocatalysts Set
Considering the challenge of sustainability facing our society in the coming decades, catalysis is without any doubt a research area of major importance. In this regard, asymmetric organocatalysis, now considered a pillar of green chemistry, deserves particular attention.
The first chapter of this volume examines the topic of asymmetric organocatalysis in light of radical chemistry. Recent import...
Navelbine® and Taxotere®
Histories of Sciences
Among the many forms of cancer treatment, chemotherapy remains an important part of the arsenal in which Navelbine and Taxotere play a major role.
These medicines result from molecules discovered by French researchers of the Institut de Chimie des Substances Naturelles (ICSN) of the CNRS, directed by Pierre Potier. By recounting this history, the authors of this book attempt to illustrate how the...
Dynemicin A, Uncialamycin and Analogues
Isolation, Biological Activities and Syntheses
Enediynes are natural products with highly active cytotoxicity and antibacterial activity, and thus have significant potential in the development of anti-cancer treatments. However, they are not readily available and can degrade rapidly during isolation; one solution is to produce them using total synthesis.
Dynemicin A and uncialamycin are two such enediynes, with similar structures, for which ...


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Quick Details
- Place of Origin: Guangdong, China (Mainland)
- Brand Name: Nordson
- Model Number: NI-500
- Electric Bolt: With Magnetic feature
- Electric Bolt Voltage: DC12V
- Electric Bolt Standby Current: 150mA
- Electric Bolt Start Current: 900mA
- Face Plate: 205Lx30WX38H(mm)
- Autolock Time Delay: 0,3,6,9sec
- Suitable For: Wood Door,Glass Door,Metal Door
Packaging & Delivery
|Packaging Details:
|Brand or nature package
|Delivery Detail:
|5-7 days after recieved your remittance
SpecificationsElectric Bolt for all kinds of door
1.With Magnetic feature
2.the open mode is optional
3.Standby Current: 150mA
Electric Bolt Lock(NI-500) with time delay suit for wood door, metal door, glass door
- Voltage: DC12V
- Start Current: 900mA
- Standby Current: 150mA
- Face Plate: 205Lx30WX38H(mm)
- Strike plate : 100Lx25Wx3W(mm)
- Bolt :17mmDIA,stainless steel 16mm throw
- Solid Bolt: polishing housing, 2000Kg Holding Force
- Suitable For: Woodeng Door,Glass Door,Metal Door,Glass Door
- Autolock Time Delay: 0,3,6,9sec.
- Signal Output: Lock status Output,NO/NC/COM
- Surface Temp: Low Temperature
- Suitable for 180° door.
- Operating temp: -10~+25°C(14-131F)
- Operating Humidity: 0~90%(non-condensing)
- Special Designed: Tested to 500000 cycles
- Face place material: High Aluminum,Carrulous Line Finished
- Weight: 1kg
- Standard Packing: 30pcs
Except for human activities
For the non-human factors of product quality issues, NORDSON Electromagnetic Lock enjoy a three-year warranty services, Access Control Panel ,electric bolt and electric strike are 2 years, exit button, bracket , and power supply will be 1 year . The customers will be in charge of the material and the maintain fees if the product damage under other conditions
Transaction History of the Supplier
Below is the information about the supplier's transactions conducted via Alibaba.com. If you require further details regarding the transaction data, please contact the supplier directly.
Transaction Overview
Export Markets
Transaction Details
This supplier has completedtransactions with buyers from .
Shipping Destination
Transaction Value
Transaction Date
Email to this supplier


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This family-friendly city hotel offers Thailand's visitors and expatriates a stylish home. Built in 2007 and renovated in 2008, the 9-storey hotel offers a lobby with 24-hour reception and check-out service, hotel safe, restaurant, room service and laundry service.
The hotel is located in Sukhumvit Soi 2 just down the road from the city's main shopping and entertainment thoroughfare. Come, visit Sukhumvit Soi 2. Feel its difference. Feel the homey neighborhood. Take an easy walk on the spacious road with pedestrian access. Get to your favorite destinations just a walk away
Along with its privileged location, all units feature a first-class d�cor with built-in wooden furniture, marble-top finishing, wooden floor, huge windows and a balcony. The rooms are en suite and equipped with a shower/bathtub, hairdryer, double bed, direct dial telephone, satellite/cable TV and Internet access. Further amenities include a minibar, tea and coffee making facilities, ironing set and air conditioning.
Guests may choose to enjoy a refreshing swim in the out door pool or ease aside the pool with a relaxing sun bath or pump up the body at the gym.
The hotel provides a daily breakfast.
The hotel accepts major credit cards including American Express, MasterCard and VISA.
24 hours reception.
Room Facilities:
Direct dial telephone
Satellite cable TV
Internet access
Tea Coffee
Iron and board
Double bed
Central airconditioned


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Adults get plenty of rad Star Wars merchandise, but I can't help but envy the options made available to kids. For example, Adidas is launching a new Star Wars Originals collection on January 8th and it's only for children. The line includes two pairs of sneakers: one with Darth Vader and one with Yoda. Both shoes feature glow in the dark detailing. Yeah, I want them too.
If your kid needs a track suit to go with the shoes, Adidas will have them available in matching Vader and Yoda styles.
See the Yoda shoes and the track suits after the break.
Product Page (via High Snobiety and Gizmodo)


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Aren't these a great idea?
Name tags painted with blackboard paint so you just write the names on.
I can imagine these at our church craft group
where people sometimes forget their tags or are new…
I found them at Cute as a Fox
Crafts. Sewing. Quilting. Crochet. Tutorials.
by Tonya Grant |Filed Under: Paint Get a Weekly Update of all Articles
Mandy @ mintnclandycreate says
This is a GREAT idea. I think these would be amazing with a magnetic back instead too. It would be simple to do & then there would be no pins to mess with!
Get the Weekly News in your Inbox so you don't miss any Crafty Updates
Tonya is the voice behind The Crafty Mummy. She dabbles in lots of different crafts – patchwork, quilting, cross-stitch, scrapbooking, knitting, crochet and sewing. This is the record of projects she has done, and the projects she dreams of getting to! Read More…


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Listen to free music by A Better Hope Foundation
Blip.fm is internet radio made social. It's easy to search for, play, and discover free music recommended by real people. Join today to create your own free station.
Jenchilada "As long as I'm here, I won't let you take what's mine. As long as I'm here, I'll fight for a better place free from your narrow mind."
Apr 13, 2010 at 3:46 pm via YouTube | AMAZON | ITUNES
Artists Like A Better Hope Foundation
Blip.fm DJs who play A Better Hope Foundation
Friends: MerchantCircle | Charity Blossom | Website Load Testing


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Bear Attack In Yellowstone
July 29, 2010 by staff
Bear Attack In Yellowstone, A man has died and two others injured by a bear that attacked a popular camp on the edge of Yellowstone Park in the middle of the night.
The two survivors, a man and a woman, suffered serious injuries bite their legs and arms, respectively, local media reported.
Two shops were destroyed in the attack unprovoked 4:00 a.m. camping in the Soda Butte in the Gallatin National Park in the far north of the famous book of Montana.
The camping area and neighbors have been evacuated two wounded and taken to hospital in Cody, Wyoming.
The identities of the three victims were not disclosed.
Officials in the region have approached the planes and helicopters to carry out an extensive search for the bear, believed that he acted alone.
Montana Fish, Wildlife and Parks Department spokesman Ron Aasheim described the incident as a random attack predators.
Although there are a lot of food stored at the site, there is believed to have been what attracted the animals, he said, adding that it is not known if this is a black bear or a brown.
The last fatal attack in Montana have occurred in 2001 when a bear maimed and killed a hunter who was a butcher elk, Mr. Aasheim said.
Please feel free to send if you have any questions regarding this post , you can contact on
Disclaimer: The views expressed on this site are that of the authors and not necessarily that of U.S.S.POST.


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Wiltshire Air Ambulance gets £1 million
The UK government has released £1 million in funding to build a proposed new helicopter emergency medical service (HEMS) airbase on land at Outmarsh Farm, Semington, near Melksham, it was announced on 23 November.
The proposed new airbase will consist of an Operations Centre for helicopters and aircrew and a base for the organisation's Charity Team.
Outline planning permission for the Outmarsh Farm site has been granted and detailed plans for the project have been submitted to Wiltshire Council.
Wiltshire Air Ambulance currently rents a hangar at Wiltshire Police headquarters in Devizes for its helicopter and aircrew while the charity team is based in rented offices in Calne.
David Philpott, chief executive of Wiltshire Air Ambulance, said: 'We are delighted to have been awarded this £1 million grant from Her Majesty's Treasury towards our new airbase. The funding will be used to complete the building, equipping and fitting out of our purpose-built Operations Centre and will bring together the aircrew, helicopter and charity team onto one site for the first time.
'Having a purpose-built facility will enable us to have full control over our future. Our preferred location at Outmarsh Farm, Semington, will enable our helicopter to reach all parts of Wiltshire within 11 minutes, as it currently does from its base in Devizes.'
Email this to a friend.


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A continuation of the baseball card industry...
After World War II ended, the baseball card trading industry began a rebound. in 1948 the Bowman Company made history in the business by signing players to actual contracts. The company issued its first annual set of cards that same year. That was followed in 1950 by the introduction of colorized baseball cards which soon made the hobby grow by leaps and bounds among kids. But with increase in productivity came competition. Sy Berger of the Topps Company absolutely loved baseball and he urged the company to get a piece of the action.
Berger got the green light from Topps and he began hanging around the locker-rooms of the New York Yankees, Giants and the Brooklyn Dodgers, and began signing star players from all three teams to Topps contracts.In order to avoid trouble with the Bowman Company, Topps inserted pieces of taffy with each card. Bowman didn't like the intrusion and tried to sue Topps but a New York judge tossed out the lawsuit.
By 1955, Topps was number one in the business and the following year Bowman conceded and sold out to them. From the 1950s until the 1970s Topps had a virtual stranglehold on the trading card business. A challenge from the Fleer Company in 1971, where they used cookies instead of gum in their cards, failed when a judge ruled against them in a lawsuit brought by Topps.
At its peak, Topps was selling 250-million cards a year and making a fortune but the players had signed contracts for only a five-year $125 deal plus $5 as a steak money bonus. Of course in the 1960s major league baseball players only made $19,000 a year so they were glad to be paid anything extra.
But the baseball trading card industry would soon change for two big reasons. First, a Major League Baseball's players' union was formed and soon got involved itself in contract negotiations for it players with Topps. Second, in 1980 the Fleer Company finally won an anti-trust lawsuit against Topps and the judge opened the baseball trading card industry to anyone. By 1988 seven companies had entered the competition, which led to fancier and more expensive cards.
In 1985, baseball cards passed stamps and coins as the most popular collecting hobby in the world and in 1988 card companies sold five billion a year. By 1992 card companies were making over $1-billion in annual sales with Upper Deck the industry leader with card and sports collectibles netting $250-million a year. Upper Deck would later make news in the sports world when it signed Yankees icon Mickey Mantle to a $2.5-million contract for only making 26 promotional appearances at their conventions.
Unfortunately in 1995 the MLB strike, combined with a glut of baseball cards and companies, slowed the business down and it never hit its peak again.
Did you know that the first company to list players' statistics on the back of trading cards was Mecca Cigarettes in 1918?
Topps made a major mistake in 1969 on Anaheim Angels Aurelio Rodriguez's trading card. They put one of the Angels' bat boys on a card with Aurelio's name below him.
In 1989 Cal Ripken's little brother Billy's card slipped by the proof-readers of the Fleer Company. Ripken was holding a bat with the bottom of the bat knob showing and written across it was a major profanity. Fleer printed the card and definitely heard from the public.
Bill Hemrich owned a sports card and memorabilia shop near the Anaheim Angels' park. In 1987 he paid $4,000 for a stack of Don Mattingly rookie cards. To his dismay he found out they were counterfeit. A friend of his, Paul Sumner, was a printing executive and when he heard about Hemrich's misfortune approached him and sketched out a trading card idea using hologram technology. He convinced Hemrich that the hologram design would be impossible to counterfeit and set the cards apart from the rest. He explained that the cards would also have a hip, high tech look to them which customers would love. Hemrich agreed with his friend and together they formed Upper Deck Cards and made history in addition to a fortune.
My best friend The Crusher from beautiful and historic Monument, Colorado use to be an avid baseball card fan. When he read my columns, he said, "I have three original Cracker Jack baseball cards. They are also tiny compared to Topps or Upper Deck cards that came with bubble gum later on. I have a "Shoeless" Joe Jackson, "Bullet" Bob Bush and Connie Mack and all from 1915."
Friends, check your attic or basement and go through those old trunks. Visit a yard sale or church rummage sale. Maybe, just maybe you'll find your own Honus Wagner, or something else of great value.


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Emma Stone Was A Vampire This Whole Time And Other News
- Robert Downey Jr. is the goddamn man. [Lainey Gossip]
- Beyonce crashed Solange's Coachella performance. [Dlisted]
- Tan Line Season Has Finally Arrived [theCHIVE]
- Gwyneth Paltrow and Chris Martin make no fucking sense. [Fishwrapper]
– Science is growing vaginas in labs now! IN YOUR FACE,… More »


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What is JotForm?
JotForm is a free online form builder which helps you create online forms without writing a single line of code. No sign-up required.
At JotForm, we want to make sure that you're getting the online form builder help that you need. Our friendly customer support team is available 24/7.
We believe that if one user has a question, there could be more users who may have the same question. This is why many of our support forum threads are public and available to be searched and viewed. If you'd like help immediately, feel free to search for a similar question, or submit your question or concern.
Can I receive 3500+ submissionAsked by NYYC on April 20, 2016 at 12:50 PM
We want to send a questionnaire to our membership; will JotForm have any issues processing 3500+ responses? Are their recommended maximums for the number of questions (i.e. columns) or responses (i.e. rows)?
Mike Fleuette
Can you please indicate if this submissions will be received in a couple of hours or days? Jotform will not have any problems receiving large amounts of submissions. As long as your current plan does not reach the limit per month, it should be fine.
I noticed that you have an ECONOMIC plan, which allows 10,000 submission per month. Currently you received only 37, so this will not be an issue.
If you are planing to receive this in a short time, you might have an issue with notification. We have a strict policy on how user use our application to send spam emails to other users. For this case we limited the amount of notification to be sent out per hour.
We only allow 1000 notification to be sent out per month for paid users, like yourself. Please keep in mind.


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occhiali oakley coz I lost my 'expensive' pair which I was gutted about. These arrived very well packaged in a case which also has a pouch and a cloth to clean them and a string to attach if you wish. They are lovely or as my niece said they're a bit spesh!! They look very expensive apart from the arms are quite thin and they keep the sun out well. They are a little large for us ladies but fit perfectly well on my little head. I am going to tighten the arms up that way they're Pristina
Notice: Undefined index: 1419 in Z:\FCK_VM\htdocs\fanzhi\index.php on line 69
ray ban frames o give good sun protection from all directions (slightly less so than the XLJ lens) and it's contoured to reduce optical distortion at extreme angles.Read more ?
These glasses are first class... perfect fit, nice and snug even on a smaller structured head but not tight on a larger one, big and small bridge pieces, polarised lenses, light to wear and pretty much indestructible. come with a superb hard carbon style case and also have a cloth bag, as well as a pot of Oakley's magical fluid that stops even the worst of grime sticking .
english meaning for the wife still hasn,t stopped laughing,no way will i wear them in public.after waiting for 5 weeksfor slow boat from china to arrive,i,m very disapointed.
I absolutely live them! The leather details on the sides are great too! Best item I've bought on amazon this far!
I'm currently rockin the Cyber-Hippy look with these glasses, they look excellent!
These sunglasses have pleased my sunglasses sale e for money. The only restriction for me is that they are slightly small for my glasses. However, for most 'modern' glasses that are of slightly smaller size, then great. The shade and depth of yellow for the glasses is excellent.
Its a while since i have had a pair of Bloc sunglasses, cant believe i have waited so long after taking reciept of these. Look good, fit well, great price. What more do you want, extremely glad i have the oakley gascan n authentic Ray Ban box, it was identical.
It came in a leather case, appearing to be identical to the real too, my hopes raised a bit. I took them out of the case (which also contained a booklet, and cloth) and tried them on. They were very light but I thought 'okay, the 'new' Wayfarers might be lighter'. Fit was exactly the same as the shop. The white 'Ray Ban P' was exactly the same as my reals, however the small laser etched RB on the left lens seems to appear as if a 5 year-old Parkinson sufferer with a biro, messy..


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Tour de France: Mark Cavendish withdraws due to dislocated collarbone suffered on stage one
By Matt Westby
Last Updated: 06/07/14 12:53pm
Mark Cavendish is "absolutely devastated" after being forced to withdraw from the Tour de France due to the injury he sustained in a crash on stage one.
Cavendish fell heavily 250m from the finish line in Harrogate and a subsequent medical examination revealed he had dislocated his collarbone.
He waited until Sunday morning to make a decision on his future in the race, but opted not to take to the start line of a punishing 201km second stage from York to Sheffield.
He said: "We kind of knew last night. I knew straight away. I normally bounce back from crashes quite well. I lie there, I assess my body and yesterday, for the first time in my career, I knew something was wrong.
False hope
"I wanted to finish. I had to get my bike to the finish. I was able to do that but I was in pain last night. I held a bit of optimism that it was maybe just swelling and it would go down in the night and I could ride this morning. It's actually worse this morning and it's not possible to start from a medical point of view.
"I'm absolutely devastated about it. One, the Tour de France is here in the UK for another two days, and secondly I've got an incredible team. It's hard, but it could be worse for me.
I'm absolutely devastated about it. One, the Tour de France is here in the UK for another two days, and secondly I've got an incredible team. It's hard, but it could be worse for me.
Mark Cavendish
"I've got friends who have come back from Afghanistan with the Armed Forces - you saw my Help for Heroes helmet yesterday. My friend Josh is a double amputee, missing his right arm. Things could be worse."
Cavendish's exit from the race is a major disappointment for the millions of fans expected to line the routes of the race's remaining two days in Britain. He would have been among the favourites to win Monday's third stage from Cambridge to London, which finishes on The Mall in front of Buckingham Palace.
'Gap that wasn't there'
His withdrawal also means there are now only three Britons in the Tour, with defending champion Chris Froome being joined by Geraint Thomas and Simon Yates.
Cavendish's crash came following a collision with Australian rider Simon Gerrans, who also fell heavily but will continue in the race.
Cavendish added: "I spoke to him after the finish and then I called him in the hotel. In other circumstances I would have braked because there was no chance I would win the stage, but I wanted that bad. I tried to find a gap that wasn't there. It was my fault.
"I need to go and get an MRI and perhaps surgery on this, so I'll try and get that sorted as soon as possible so I can get back to racing as soon as possible."


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Business Category :
Phone number :
Fax number :
Filipino Community Center- Your home for gatherings, events & occasions. Filled with many Filipino food that will take you in a plae called home. We accept phone call orders that will be able upon pick up within the agreed time. So call now!!! Got an upcoming party, event, team building, seminar or trainings?? Want a Filipino filled atmosphere with an easy budget?? Dial our numbers now and book your exciting event with us and experience Filipino celebrations like never before. Hurry now before somebody else books on your day!! See yah!
Please fill the given form below


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Whether learning a language, mastering a sport or gathering gobs of greenbacks, starting young is....
Legacy wants you and your family
to have a hap....
Spoofing: What is it? How do I report it?
occurs when a caller deliberately falsifies the information transmitted to your
caller ID display to disguise their identity.
posted on April 19th, 2017
by Legacy Credit Union
Newfound Wealth: Thinking Through the Options
Whether you are the recipient of an inheritance, a windfall or a bonus, new wealth brings with it new issues.
posted on July 20th, 2016
by Clayton Aho
Copyright © 2015 Legacy Community Federal Credit Union. All Rights Reserved.


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With First Tutors: Music you can search for a Enfield conducting teacher. Conducting tuition are a brilliant method to start an entertaining new hobby, acquire a new talent and gain confidence in conducting. Use our site to find Enfield conducting teachers and choose which best suits your needs so you can start your conducting tuition in Enfield today!
This is the best way to contact Enfield conducting tutors in the UK, helping you discover Enfield conducting lessons close to you and Enfield tutors to assist with any instrument, for example, piano, violin or guitar. We can help you find Enfield conducting tuition or a Enfield conducting tutor to prepare for conducting grades and improve your conducting skills! Our search will order Enfield conducting tutors local to you according to their lesson charges and proximity to you.
If you are a conducting teacher wishing to offer your conducting lessons in Enfield or throughout the UK, please register with First Tutors: Music or learn about us here. Becoming a Enfield conducting teacher is a fantastic way to improve your own skills through providing conducting tuition while helping others, all in the Enfield area!


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Polo Ralph Lauren Corporation
News about Polo Ralph Lauren Corporation, including commentary and archival articles published in The New York Times.
Open Thread: This Week in Style News
Nashville vs. Columbus, loaner jewelry and more....
May 19, 2017, Friday
From Pantene to Polo: The New Man at Ralph Lauren
Patrice Louvet's appointment is the latest example of a luxury brand looking to the world of consumer products for a new leader....
May 18, 2017, Thursday
Under Cover: Fashion's New Dress Code
Far from being stuffy, a longer, looser dress in breathable cotton or linen is effortlessly cool....
April 26, 2017, Wednesday
Stores Take Flight From Fifth Avenue in Manhattan
Companies are finding it harder to justify the cavernous spaces and sky-high rents along the shopping strip, as tourism slows and online shopping speeds up....
April 4, 2017, Tuesday
Brand to Know: The Scandinavian Line That's Anything but Minimal
Haal, the three-year-old project by Anders Haal, features items like a skirt emblazoned with the slogan "Oprah for President."...
March 27, 2017, Monday
From Couture to Cuisine: Ralph Lauren Opens a London Restaurant
The American fashion designer's latest foray into the food business debuted in his brand's flagship store on Regent Street....
February 20, 2017, Monday
Tensions Between New and Old, Played Out at Ralph Lauren
The fashion brand is changing its chief executive, one in a rash of executive moves in the fast-changing fashion industry....
February 2, 2017, Thursday
Four Puzzlingly Perfect Patchwork Bags
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Keāā is an artificial Archipelago of islands that were created by Colombia in 2030. Its capital is Costa de Oro, with a Population of 5 million people. It is located in the Pacific Ocean at these coordinates.
Latitude: 25.30109
Longitude: 167.11162
Distortion: 1.22
Basic Info
Keāa is made up of 6 islands, the largest being 105,000 sqkm, with the smallest being just 150 sqkm.
Animals & Inhabitants
Write the second section of your page here.


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Gardai trying to locate the third man suspected of involvement in the brutal rape of a woman in Dublin last week fear the man may have fled the capital.
The violent attack occurred last Thursday as the victim was making her way home from a local garage.
Gardaí have so far arrested two people in relation to the incident, but fear one of the suspects, originally thought to be in hiding, may now have in fact fled Dublin.
Yesterday it was reported that the man may have fled the Clondalkin area but today it is thought he may have fled Dublin altogether.
Two men aged in their late teens and early 20s were arrested by gardaí and questioned at Lucan Garda Station over the weekend, before being released without charge. It is understood the victim of the attack, who is in her 30s, was returning home after stopping at a local petrol station to buy groceries.
She was pushing her bicycle along the footpath away from the direction of Clondalkin village when she was allegedly grabbed by three men. It's now known that one of the men raped her.
Though the woman was threatened at knifepoint during her ordeal, there is no indication the weapon was used on her.
The victim did not know her attackers. After raising the alarm herself, the woman was taken to the Sexual Assault Treatment Unit in the Rotunda Hospital. On Friday morning gardaí from the technical bureau recovered the victim's bicycle from the scene.
A running shoe and other items were also collected for forensic examination. Specialist gardaí from the Clondalkin district will interview her further about the attack.
It is expected that gardaí will establish more details about the incident during this interview.
"A number of online threats have also been issued, with local criminals threatening to kill the men involved," the source added.
The threats have been directed at the perpetrators since the morning of the attack, and it is understood the names of individuals suspected of involvement were shared on social media.
Gardaí have received a massive response from the public since issuing their appeal for information on the brutal attack.


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"Will you be getting more of these in stock? I need to buy a new one (to replace the much beloved original one) for my dad's 96th birthday. Thanks!"
I ordered this quilt some time ago but I still love it!! It is a very heavy weight and the colors are beautiful! I put a blanket underneath it and can use it all winter long in the midwest winters!...
Moroccan Spice 3-piece Quilt Set
ITEM#: 10325028This vibrant quilt enlivens the bedroom. Featuring a paisley pattern, the 100-percent cotton quilt set keeps cozy.
- Set includes: Quilt, two shams (only ones sham in twin set)
- Pattern: Paisley pattern in red and green
- Style: Patterned
- Cover materials: 100-percent cotton
- Fill materials: 100-percent cotton
- Backing materials: 100-percent cotton
- Care instructions: Machine washable
Twin Dimensions
- Quilt: 68 inches wide x 86 inches long
- Sham: 20 inches wide x 26 inches long
Full/Queen Dimensions
- Quilt: 88 inches wide x 92 inches long
- Shams: 20 inches wide x 26 inches long
King Dimensions
- Quilt: 106 inches wide x 92 inches long
- Shams: 20 inches wide x 36 inches long
The digital images we display have the most accurate color possible. However, due to differences in computer monitors, we cannot be responsible for variations in color between the actual product and your screen.
|Full, Full - Queen, King, Queen, Twin
|See details
|Model Number
|Moroccan Quilt Set
|Country of Origin
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Customer Reviews
Most Recent
Love Love Love!
I ordered this quilt some time ago but I still love it!! It is a very heavy weight and the colors are beautiful! I put a blanket underneath it and can use it all winter long in the midwest winters!Read More
Nice quality quilt set
I've had this quilt set for a couple of years now and it's been through many washings. It has held up well even with dogs on the bed.Read More
Moroccan Quilt
This Quilt is so pretty I use it as a Quilt/spread on my bed. I has last for many years with repeated washing and the color has not faded. I would recommend this product.Read More
Love this print and softness!Read More
Great colors but is a little small for my king bed but works great on my Queen size bed.Read More
Most Helpful
Disappointment compared to summer quilt
Last summer, I got a white Trousseau quilt from Overstock that is beautiful, thick, and luxurious and I absolutely fell in love with it! This winter, I decided to order another quilt that had richer colors to replace the white quilt during the fall/winter. Since the Trousseau quilt did not come in a richer fall color, I ordered the Moroccan Spice quilt set. While the colors are pretty nice, the Moroccan quilt in no way resembles the quality , beauty and comfort of the Trousseau quilt. The Moroccan quilt is a lot thinner, stiffer and cheaper looking and not comfortable at all. And I believe it even cost more! I should have returned it, but I'm hoping maybe after washing a few times it will improve, but no way would I take my Trousseau quilt off the bed. We still sleep under it and I use the Moroccan quilt for a splash of color on top of it during the day. Overall, not impressed and a bit disappointed, since I love the Trousseau quilt so much. I'll probably continue my search for the perfect fall/winter quilt next October, but I'll be a lot more careful.Read More
Perfect, after two bottles of RIT
I had fair warning from other reviewers that the colors on this quilt were actually brighter than one might anticipate. My bedroom walls are 'Pompeii Orange', and, upon reading the quilt described as 'pumpkin' - I thought - ' I can live with that'. - and ordered. So my dismay upon opening the quickly shipped package was tempered with minimized expectations. The colors are indeed bright - a true, deep orange, with no browns but lots of yellow tones - think over-ripe peach - and an accent of lime-green throughout the paisley pattern. The pattern itself is gorgeous,though, and the quilt of good quality - I sought a solution. Which I found in two bottles of dark brown RIT dye. I soaked and agitated the quilt and shams for forty minutes, rinsed with cold water, and threw it in the dryer. Two hours later, I had a beautiful, muted toned, luxe and antique looking quilt that washed and dried so well it feels a distant cousin to the one I opened hours before. A lot of trouble for a new item, right? I gave it five stars because it replaced a quilt that I paid more than four times as much for, and this one, now, is more soft and beautiful. I love it.Read More
Didn't like it at all
I have to say that this time I was very disapointed. I really like reading the reviews before making a decision and I feel like I either got the last one (because now I see it is out of stock) or just a really poor one. The colors were actually DRAB. Not really orange, rust, or red. Just a mixed version of those colors with no life to it at all. It looks MUCH better on my monitor than in real life. It is very stiff and thin. I wish I would have listened to the reviewers that were negative. I thought I would give it a chance though because the over all ratings were pretty high. Don't make the same mistake!Read More
Wonderful Quilt Set
I bought this quilt set for my sister. We took it out of the bag and put it right on her bed, the colors looked great, like pictured, the weight felt right. My concern is whether it will wash well...we will have to wait to see. Over all I am very please with my purchase.Read More
good quality and price
This was a good quilt for the price. It fits a king sized bed by using a dust ruffle that is not included. The color pictured was accurate. Pleased with this product.Read More
Questions & Answers
We hope to restock this set if it becomes available again. Unfortunately, we cannot guarantee this item will be restocked. Please check back with us periodically
"where are these Moroccan Quilt sets made?"
Hello goofer88, This quilt set is made in China. Thank you for shopping with us!
China unfortunately.
"This appears more "coral" in color...not red. Which is it?"
"Coral" is the correct answer from this qualified lexicographer (Merriam Webster, Oxford English Dictionary). Keeping in mind that, apart from the many colors, tones, and shades seen in the various species of natural corals, historically, the color known as "coral" can vary from weak pink, through strong salmon, to scarlet (the latter color, being slightly orangy and less saturate, differs significantly from true red). That said, and worded in popular parlance, there are numerous salmon-colored areas in this fabric's pattern, as well as near-equal amounts of scarlet. Hence, the addition of salmon-colored toss pillows immediately heightens the overall "coral" effect, even as subsequent washings of this quilt's cotton fabric progressively weakens or softens the scarlet and diminishes the impression of redness. Clearly, "coral" is the answer.
The red and orange are predominant colors in the quilt, however, the allover appearance with those two is coral.
I would say it is more towards the coral with a brick tone. I like it very much.
It is definitely not red. I guess coral/deep orange is the description I would probably use.
Most definitely coral!
"size deminsions of moraccan spice queen size quilt"
The dimensions of this quilt are 88 inches (W) x 92 inches (L). The shams are 20 inches (W) x 26 inches (L).
The size was just as stated, but I have a king sized bed and would have loved for it to be oversized. However, it is just right when you buy a bedskirt to go with it.
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Our standard shipping method is ground shipping. We also offer expedited shipping for most items. Your final
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** Most Oversize orders are delivered within 1-4 weeks. Some orders may take 6 weeks to be delivered.


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Help others choose the best products...Write a review
|incl. VAT
|£4.57 £4.33
|excl. VAT
Handkerchiefs are basic toiletries. If it has something missing in every home and is the obvious choice handkerchief. We offer you a Kleenex Kleenex Original Box 88 units, which by its subtlety irritate nasal area. They are supplied in packs of 3 + 1 gratis after 88 units.
Specifications can be changed without notice. Images are for illustrative purposes only. Retail Price (MSRP) means the manufacturer's/supplier's suggested retail price.
Link to Manufacturer's Website: Enter link to the external review


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Can the Blazers catch postseason fire like the Warriors did?
Last year the Golden State Warriors surprised everybody with exciting outside shooting in the playoffs. Could the Portland Trail Blazers do the same this year?
More NBA: Power Rankings | Expert Picks | Latest news & notes
Imitation is the most sincere form of flattery, as they say.
During the months of April and May of 2013, the Golden State Warriors caught lightning in a bottle and electrified the NBA playoffs with it. The Denver Nuggets finished with their best regular season in the team's NBA history (twice won 60 or more games in the ABA), but they were cut down in the first round of the playoffs by the Warriors and their incendiary 3-point shooting. Before the Warriors lost to the San Antonio Spurs in the second round, they were the fun, new team on the block with a very interesting outside-oriented attack and a dynamic young guard leading the way.
Trying to make heads or tails of the Western Conference playoff picture is pretty impossible with roughly three weeks remaining. We still don't know which eight teams we're getting, and five through nine in the West are separated by two games in the standings. Once we find out which eight teams are in, we'll next be looking for the team that can replicate what we've seen from upsets of the past and make a name for themselves in the first round of this year's playoffs.
If you're trying to find a team capable of doing what the Warriors accomplished in 2013, taking a journey to the Pacific Northwest is the way to go. The Portland Trail Blazers were a pleasant, 3-point happy surprise to begin the season, jumping out to a fantastic record and baffling teams left and right with their passing and shooting prowess.
While the defense of the Warriors was much better and the offensive numbers weren't nearly as impressive as what we're seeing from Portland this season, the components show a lot of similarities.
It all starts off with two point guards who seem impossible to defend. Stephen Curry was a human flamethrower during last season as he set the single-season record for 3-pointers in a season. He left opposing defenses feeling uneasy with the ball in his hands because you never knew when a shot was going up. To a lesser degree but a relatively similar impact, Damian Lillard has had that effect on defenses this season. The term "Lillard Time" draws similarities to the insecurity a defense felt when Curry had the ball.
The starting shooting guards, Klay Thompson and Wesley Matthews, are limited attackers but also two guys who have been known to bury opponents with sweltering 3-point shooting. The biggest difference between the two units would have been the small forward position, where the Warriors tried to work Harrison Barnes into a consistent role (which worked when left open against Denver) and the Blazers have Nicolas Batum bringing fantastic all-around play to his team.
Both teams also get by quite nicely with a big man pairing that complements one another well. The Blazers roll with Robin Lopez and All-Star LaMarcus Aldridge, a couple of big men who can rebound well and fill their respective roles on offense beautifully. The Warriors had Andrew Bogut with David Lee when Bogut was healthy, playing extremely well with each other on the court. Bogut handled the defense while gave opponents double-doubles regularly.
You can even see similarities in the benches, with two second units possessing role players ready to step up to hit big shots and very competent lead guards to run those units.
Where the Blazers can imitate the Warriors and try to give us a second showing of surprise postseason success is by doing what they do best: smothering opponents with shots from the outside. Aside from that Warriors team having a historically high 3-point percentage due to unreal efficiency from the corners, these two teams are fairly alike all over the floor. Check out their respective shooting charts:
Aside from the right corner 3-point spot, the Blazers and last year's Warriors have nearly identical shooting charts. They both use clever sets and good passing tenets to get their shooters open looks from outside. The ball moves a lot and the players stay in motion. They play well off of their big men and Lillard is capable of igniting a quarter in a way that isn't all that different from what Curry was doing last season.
With a guard who can take over and seems more comfortable behind the arc than in front of it, shooters spacing the floor, and a scoring big capable of taking stretches of the offense to draw the defense in (more so with Aldridge than Lee), the Blazers' chances of shocking the world and finding their way to the second round don't seem all that impossible. The difficult part of it will be finding an opponent who struggles to keep up from the perimeter.
The most likely opponents of the Blazers in the first round are the Oklahoma City Thunder, Los Angeles Clippers, or Houston Rockets. None of these three teams shoots the 3-ball all that well in terms of percentage (14th, 17th, and 20th, respectively). However, the Thunder have two stars to rely on, as do the Clippers and Rockets. And the Rockets may not shoot the 3-ball efficiently but they do shoot it a lot and can get very hot from downtown.
It may be difficult to find an opponent in the West to play the part of the Nuggets this postseason, but it doesn't seem difficult to find an imitation candidate of last year's Warriors in this year's Trail Blazers.
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