text:
Who the fuck comes up with a family picture like this? Daaaaad! Bobby's got a boner! Daaaaad, Mary farted on my weaner! I'd be the most pissed off kid in my school if my dad had me take a picture like this!
Are you still wondering how people like James Homes happen?
Moms kinda hot actually
You need to go back to the eye doctor and get new glasses preferemshaved. I wouldn't fuck her with your mom's dick.
As my age rises my standards lower. Just sayin.
WTF? Why get the kid touchers excited with a pic like that?
Hey Mommy its like we fit perfectly together..........
cock pushups - bringing families closer since 1969
must be mormons, they only thing more fucked up than posing for this picture is posting it on the internet
Oldest boy just hit puberty a little early...
i thought the dad goes on top.
legalize incest.
more to this than meets the eye...mom has the biggest smile
is that lenny when he was a kid?
They need to get out of that fucking cave and buy some clothes.
I feel like a perve just looking at that picture..
I would have that that Sandusky looking dude on the bottom would've been on his back instead of his belly
Their shrink is going to need a stronger couch.
Must be americans...
those are some real fucked up people right there!
You would be amazed what goes on behind closed doors ln alabama .
The 2 sons just hit puberty
Either way it's unacceptable but, to me, mom is not in the picture.
John Tesh?
I bet you can smell ass from that pile of stupid,.,.,.,.,.,
Actually, lenny, Mormons are all about modesty. We're not supposed to wear things that show our shoulders or too much skin.
^^^ yet you show it in your avatar. smh
And she sent in pics of her udders. Yeah, that's reeeal modest. Fucking hypocrite.
That's right, mattyc--I'm a modern Mormon and a rebel...that is all.


text:
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subset: commoncrawl


text:
|1,050 sq. ft.
|Property type
|Minimum Stay
|4 nights
The apartment is a fully furnished and fully outfitted serviced temporary residence apartment appointed with executive level furniture, elegant home furnishings/accents, state of the art electronics, and luxurious linens and towels. The apartment is outfitted with a very comprehensive kitchen, housewares, and cookware package. Our apartment is a luxury 2-Bedroom / 2-Bath apartment with a living room sleeper sofa, located right in the heart of the very trendy Arlington area – just minutes from Mid-DC and Georgetown! The apartment is on the 22nd floor and faces Downtown Washington DC so all of the monuments are visible from the apartment windows.
We also several apartments, virtually identical to this one, on upper floors, with a Virginia facing view, at a lower rate.
The building is located right at a METRO station on the very convenient Orange Line, just outside of the DC city limits. It is less than 8 minutes on the METRO.
Apartment: The apartment is located in a newer, modern high-rise building. It is a spacious 2-Bedroom / 2-Bath full-size apartment at 1150 sq. ft. The in-apartment amenities include - over-sized picture windows, walk-in closets, and track lighting.
The apartment offers essential amenities like wall-to-wall carpeting, ceramic tiled baths, crown molding, a gourmet kitchen, and abundant storage space. The quality of the furniture and housewares in our apartments is head and shoulders above our competition.
The apartment Kitchen is a full kitchen with full size appliances including a built in microwave, dishwasher, gas range, stove, pantry, and a full size refrigerator with freezer and ice-maker. There is a washer and dryer in front hall closet of the apartment.
The Living/Dining Room is spacious with a full size sofa, accent chair, and coffee and end tables. The large dining table with 6 dining chairs seats 6 comfortably and there are 2 extra padded folding chairs located in the front hall closet. The sofa folds out to a very comfortable Queen sleeper.
The TV package includes expanded digital cable channels, all HD channels, plus Starz HD. The living room TV is a 42"-HD 1080i flat- screen Smart TV, the bedroom TV is a 32" HD 720i flat screen, and the stereo plays iPhone/ iPod. The Living Room TV is internet accessible so you may watch your own Netflix, Hulu, Amazon, etc. The private in-apartment Wi-Fi is free of charge. The apartment phone system includes free nationwide long distance, free local calling, and voicemail.
There is a King size bed in the Master Bedroom, a Queen size bed in the Second Bed Room, and a very comfortable Queen sleeper sofa in the Living Room. The mattresses are Double Pillow Top. The sheets are 400 thread count Egyptian cotton. Each bedroom has a walk-in closet. There are 2 full bathrooms. There is a soaking tub with shower in Master bath.
Building/Community Amenities: As a guest of Zen Hospitality, you have complete access to of all building amenities and common areas. Spend your leisure time in the community by availing yourself to the first class community facilities. There is a magnificent outdoor split-level cascading pool with Jacuzzi. (Open Memorial Day to Labor Day). There is a poolside Outdoor Patio with Grilling Stations. The Grand Club Room has a Billiard/Game Room, a big screen TV, a DVD player, surround sound, and a full catering kitchen. The Executive Business Center has computer access, printer, copier, fax machine, and wireless service. The 24-hour Fitness Center has resistance machines, free weights, and several types of cardio machines with individual TV screens and device jacks. The property also has a Library with a "take a book/magazine-leave a book/magazine" system. The lobby has security controlled access with a visitor call system, on-site valet dry cleaning and laundry service. There is a 24-hour key access system for your ease of arrival and departure. There are many restaurants, shops, and stores right at the property and within casual walking distance of the property.
The property has a Walk Score of 95 out of 100 - A super convenient walker's paradise!
Activities and Attractions: You will never experience a dull moment in and near the excitement of Washington D.C. Explore major attractions in Arlington and Washington D.C.
In Arlington, you can check out the Mount Vernon Trail, the Pentagon Memorial, Arlington National Cemetery, and the U.S. Marine Corps War Memorial, among many other famous locations in Arlington.
Mid-Washington D.C. - The apartment building is located 1 block from the Courthouse METRO station on the most convenient Orange Line; it is 2 short METRO stops in to midtown DC – less than 6-minutes on the METRO to see the White House, The National Mall, all museums, monuments and DC sights.
Arlington is a very hip and trendy urban young-professional area and this building is right in the middle of it all. There are many restaurants, clubs, shops, and activities within close walking distance. There is a Whole Foods grocery store within 3 blocks of the property.
Parking: Secured access underground parking at the property with secured apartment elevator access is only $10/night per vehicle - if purchased in advance for the entire stay.
- SEE OUR MID-TOWN DC LISTING/REVIEWS at HomeAway Listing # 3021359 / VRBO #406276
I have over 20 years' experience in the hotel industry and 10 years' experience in the corporate housing-temporary residence business. I have a passion for customer service, quality, and attention to detail. This is a small, family run rental operation with boutique flair. I personally over see every aspect of your stay with us!
This is a newer high rise building in the heart of the hip and trendy Ballston area.
VALUE - The rental rates at this property are much less than mid-DC rates, but the building is just minutes from the heart of mid-DC on the METRO, and thus a great DC Visit Value.
FAMILY FRIENDLY - The building and neighborhood are VERY family friendly!
QUALITY – Our apartment quality is far ahead of any of our competitors – Our furniture, housewares, sheets, towels, linens, and electronics are far superior to any in our market.
AMENITIES - The property has a Fitness Center, an Executive Business Center, and a Grand Club room with an adjoining billiard room. The Grand Clubroom opens out to the poolside patio area that has patio furniture and gas grills for you use.
CUSTOMER SERVICE – We are a small family run business each person here to serve you is an "Owner".
POOL - The property has MAGNIFICENT 2-tiered double swimming pool with cascading waterfall between the 2 tiers. There is also a poolside Jacuzzi
VIEW – We have only upper floor apartments with great views. Several select apartments have DC Skyline / Monument Views.
The condo was a wonderful place to stay while we explored Washington, D.C. for two weeks. Six of us (my husband and me, our two daughters and my in-laws) were all very comfortable, it was nice to come "home" at the end of a day filled with walking to and through all the monuments and museums. It wasn't the same condo in the pictures the link showed, but same building with a different view. Having a kitchen allowed us to enjoy a few home cooked meals and being able to do laundry there helped big time since we traveled all the way from the West Coast only bringing one carry-on each. The staff at The Avalon was very nice and all of the residents there were friendly. The Metro stop was closer than I was told, really it's just across the street and up the stairs; hang a left once you are in the plaza and you're there. The restaurants were good too; we ate at The Courthaus Social a few times (loved the Nutella Pancakes and the burgers) because the staff was so friendly. We even lucked out! On Sat. morning just a block up from The Avalon was a great farmers market where we had some of the best apple cider and cider doughnuts ever. The fresh cheese and fruit made for a great picnic between museums.
Next time we make it east I will make sure to contact Zen Hospitality.
We loved our stay in this well-appointed apartment! We quickly figured out a shortcut to the metro station (through the garage of a nearby building) that helped especially during the snow & cold weather we encountered during spring break. For those who like to cook some during a trip, you'll find a good selection of pots, pans, & even disposable storage containers for leftovers (a very thoughtful inclusion!). We enjoyed the view of the city, the convenience of restaurants and the metro station, and the friendliness of the staff & residents.
Visited the DC area with a family of 5 [3 little children]. Close to the metro, AMC theater, eateries. Clean and well appointed apt. Quiet and all amenities provided [if you are thinking of using the sleeper sofa you will need to bring extra linens and etc]. We were able to drive or take the metro everywhere within 20-30 minutes. Will definitely rent from Zen again.
Our communications with Mark was excellent. He worked with my sister & I to have a great experience with our 78 year old parents visiting Washington, DC for the first time. The front desk was warm & welcoming. We had no issues with check in. The apartment was well equipped and furnished with nice furniture and good mattresses. Finding the local restaurant menus and the map in a drawer was a life saver. We were absolutely thrilled with the view. We used the Metro Rail that was less than two blocks away. We enjoyed the Court House Plaza restaurants and stores. Having the small market downstairs was very advantageous. We had a marvelous time touring the city all day, but a calming, relaxing place to wind down and rest in the apartment all night. We really loved it. It made good memories great. Thank you!
Only a block and a half from the Metro makes this condo a perfect place to stay for a family wanting to visit the sites of DC. If not eating in, plenty of eating out choices nearby. Condo is clean and quiet with lots of amenities. A home away from home.
I honestly can't say enough!!! The apartment was spacious and perfect for our family of 5 (3 of which are teenagers)! It was clean, well stocked, and walking distance to restaurants (ate at the Cheesecake Factory and an ice cream shop that made the ice cream right in front of you with liquid nitrogen--so cool!), as well as a stores like CVS/Walgreens/Fresh Food Market, and my have to have every morning...Starbucks. Loved having the parking garage each day and the wonderful view! Only think I would note--pool closes at 8pm, not a bad thing, but good to know. On the positive, the pool has a lifeguard on duty which is nice and the patio had 2 grills and lots of seating for eating outside if you would like. The area is very safe and there were people out jogging on the beautiful paved roads/walkways day and night. Even walking distance to a movie theatre and very close to Arlington Cemetery and the typical tourist sites over there. Very short drive or commute to DC. Mark was wonderful through the entire process! Thanks again!!!
The property is located in the very hip, trendy and family-friendly Courthouse section of Arlington, just outside of the DC city limits. It is just minutes to mid-Washington DC and to Georgetown. The apartment building is located 1 block from Courthouse METRO on the very convenient Orange Line. It is 2 short stops on the METRO into mid-DC which takes less than 6 minutes.
There are many restaurants and leisure attractions surrounding the property within casual walking distance. There are several restaurants, a large park and a public library within walking distance. There is a mega Whole Foods grocery store less than 3 blocks away. The property is located just minutes from the ultra-trendy Georgetown neighborhood in DC.
The Property has a Walk Score of 95 out of 100 – A super convenient walker's paradise!
|Rental Period
|Minimum Price
|Additional Nights
|Weekend Night
|Monthly *
|Event Price
21 Jun 2017 - 4 Jan 2018
4 night minimum stay
for 4 nights
My Standard Rate
4 night minimum stay
for 4 nights
|Tax Rate
All rates are subject to change without notice.
At times we may accept bookings for time periods less than the stated minimum night stay. Those nightly rates will be quoted separately and at a higher nightly rate than posted above.
Any stays of less than 5 nights that span a weekend are subject an additional Weekend Premium Fee of that time period.
Apartments with DC Skyline / Monument views are available at an additional charge and subject to availability.
A 50% Deposit is due upon reservation. The balance is due 30 days before arrival.
* Approximate monthly price. Actual pricing will depend on the days of the month you stay.


text:
As Boulder County is working to create a management plan for 18,000 acres of open space, many locals are rallying against the part of the plan that could allow genetically modified plants to be allowed on the land.
Recently hundreds of anti-GMO people gathered at the Boulder County Courthouse to oppose these kinds of crops on the open space. A volunteer advisory panel has been working since February to create a set of recommendations for the management plan that oversees the 18,000 acres. The members of the group – Cropland Policy Advisory Group – span a wide range of farmers (both organic and conventional) and community members. However, the anti-GMO protestors complained that there hasn't been any time for public comment on the plan on the schedule of twice-monthly meetings.
The anti-GMO crowd packed the hearing room for the county commissioners meeting. The meeting allows 30 minutes of public comments once a month. Only a few were able to speak, but the county commissioners said there would be plenty of time in the future for comment on the subject of GMOs
The draft of the plan is due in October. The Parks and Open Space Advisory Committee and the Food and Agriculture Policy Committee is set to review it.
The recent rally stems from a request made in 2008 by six farmers who lease part of the county-owned land and asked to plant sugar beets there. The sugar beets would require less herbicides and would help the farmers stay competitive, they said. The anti-GMO protesters argue these sugar beets could contaminate nearby organic farms.


text:
Quat is a program for generation of 3d fractal objects. These objects are Julia sets using quaternions. Features include calculation of usual images and stereo pair images for real 3d views, a user-specified true color palette for flexible coloring, 5 iteration formulas, and intersection planes to view the interior of the three-dimensional fractal. A text mode version for batch calculation is also available.
A tool for securing DNS communications between a client and a DNS resolver.
A polyhedral extraction tool (PET).


text:
A love story set in the backdrop of media. The movie is written and directed by debutante Sreebala K Menon. Dileep plays Rupesh Nambiar, who works in a news channel. Nikhila Pavithran plays the female lead. She does the role of news reader Kabani. Sreenivasan plays the channel editor Ummer Abdulla. The movie showcases many interesting facts about media.
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Sooo, Ive a pile of info Id like to share with others online...(7 Posts)
Mum2Fergus Wed 23-Jan-13 21:39:17
NetworkGuy Wed 23-Jan-13 21:58:42
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NetworkGuy Fri 25-Jan-13 10:39:59
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Our once chilly, yet beautiful, Barrel Room is finally being converted to a new area for patrons. This has become an area we can adapt to our needs. We can offer wine tasting on a typical day at these charming barrel tables. You can more easily browse for your favorite wine as they are displayed for easy access! The Mercantile is incorporated in this room for now, but there are plans for its expansion into our existing lab area.
Another great possibility is that we can seat up to 100 people indoors. Therefore, when we offer some of our wonderful winemaker dinners or themed events, we can have more space to offer better service and more comfort for our guests!
Make time to visit and enjoy our progress!!


text:
Knuckleball Kim Roberti's 8 x10 oil on gessobord
painting by artist Kim Roberti
10 in X 8 in (25.4 cm X 20.3 cm)
oil on gessobord
$199.95 USD plus $9.95 USD s/h in the U.S.
(for international shipping, please contact me)
This painting is available through an online store or blog page.
More Paintings by Kim Roberti
More in Figurative Paintings
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Keyword Tags
figure gessobord kim roberti kims knuckleball oil oil on gessobord painting roberti small
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The Daily Painters Art Gallery - www.dailypainters.com
© 2017 Daily Painters Gallery. All artwork is copyrighted by the individual artists.
Images may not be reproduced without the permission of the artist.


text:
Supervisor | Gurgaon | Male | Exp.1-3yrs | Rs.10k-11.5k Pm ( 1 - 3 yrs)
Aasaanjobs Pvt Ltd
RS 1,25,000 To 1,50,000 Gurgaon, Gurgaon Rural
- Client Handling At The Pos Level And Front Dealing With Client - To Conduct A Survey At The User Location Before The Approval Of Job - To Maintain Packing List Of The Goods To Be Relocated - To Keep A Check On The Quality Of Packing And Gu...
Key Skills : - client handling at the pos level and front dealing with client,sales executive,marketing,distribution,business development executive,business...
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Key Skills : sales executive,marketing,distribution,business development executive,business developer,regional manager,head sales,channel sales,sales...
Sales Promoter | Gurgaon | Female | Exp.1yr | Rs.10k-12k Pm ( 1 - 2 yrs)
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Need To Travel Store To Store Across Delhi Ncr. To Sell Soul\' Products In Modern Trade, Sample Soul\' Products To End Consumers In Store & Execute Any Consumer Promotion In Store As Decided By Company Additional Payout : Travel Reimburse...
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Need a Head Sales ( 0 - 1 yrs)
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To lead and direct Battery business team across the locations to achieve the sales revenues, profitability and effective customer services. Sector - Consumer Electronics / Power & Evergy Location - Gurgaon Designation - Head Sales
Key Skills : head sales,marketing head,customer sales executive,business development head,marketing incharge
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1. Leading team of Expert Sales/ Medical Representatives a. Coaching & Development of Representatives to deliver best-in-class HCP engagement and in-clinic effectiveness b. Appropriate Segmentation & Targeting of HCPs so that most relevant ...
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Home Based Marketing Job ( 0 - 7 yrs)
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Key Skills : sales executive,marketing,distribution,business development executive,business developer,regional manager,head sales,channel sales,sales...


text:
ATLANTA, April 1
 Howard Carmack, aka the "Buffalo Spammer," was found guilty
yesterday on all 14 counts by a jury in Buffalo, New York. Carmack's criminal
conviction stems from charges that he used fraudulently obtained Internet access
accounts to send forged spam emails.
EarthLink (Nasdaq: ELNK), one of the nation's leading Internet service
providers, played an instrumental role in the case. Mary Youngblood, EarthLink's
abuse team manager, provided expert testimony and evidence about the spamming
and spoofing violations that the company uncovered during its year-long
investigation into Carmack's illegal Internet activities. In addition,
EarthLink's outside counsel Pete Wellborn also testified in the case.
Last year, EarthLink won a $16.4 million civil judgment and injunctive relief
against Carmack in U.S. District Court in Atlanta.
The following statement can be attributed to Karen Cashion, EarthLink's
assistant general counsel who led the ISP's civil case against Carmack.
"This criminal verdict puts spammers on notice that in addition to being
held liable for millions of dollars in civil damages, they can also be sent to
prison for sending fraudulent and illegal emails. EarthLink is pleased to have
been able to offer testimony against Howard Carmack, and we commend the New York
Attorney General's office for its successful prosecution of the criminal case.
"In addition to consumer education, legislative efforts and innovative
tools like spamBlocker to protect consumers' inboxes from unwanted, unsolicited
junk email, EarthLink will continue to pursue legal action against spammers with
the same tenacity that led to the case against Mr. Carmack and others like him.
Howard Carmack's criminal conviction demonstrates that spammers who continue to
send illegal emails will not escape the law."
About EarthLink
"EarthLink revolves around you(TM)." Celebrating ten years as a
leading national Internet service provider (ISP), Atlanta-based EarthLink has
earned an award-winning reputation for outstanding customer service and its
suite of online products and services. According to the J.D. Power and
Associates 2003 Internet Service Provider Residential Customer Satisfaction
Study(SM), EarthLink is ranked highest in customer satisfaction among high-speed
Internet Service Providers. Serving more than five million subscribers,
EarthLink offers what every user should expect from their Internet experience:
high- quality connectivity, minimal drop-offs and ISP-generated intrusions, and
customizable features. Whether it's dial-up, high-speed, Web hosting, or
wireless Internet service, EarthLink provides the tools that best let
individuals use and enjoy the Internet on their own terms. Learn more about
EarthLink by calling (800) EARTHLINK or visiting EarthLink's Web site at


text:
It only takes a minute to get started. Fill out our uncomplicated sign up form and login to the website.
This step is noncompulsory but will dramatically increase your chances of getting noticed by other people on the website. Introduce yourself, your interests and upload some good photographs of yourself.
Utilise our website's state-of-the-art search to find members who match your desired criteria. Or just scan through listings and find members that attract you.
Located someone who meets your requirements? Send a note to them or just a wink and see if anything happens. With a little luck you'll be on your way to finding your perfect date.
It only takes a few minutes


text:
Church of the Early Middle Ages (476–800)
The Church in the Early Middle Ages covers the time from the deposition of the last Western Emperor in 476 and his replacement with a barbarian king, Odoacer, to the coronation of Charlemagne as "Emperor of the Romans" by Pope Leo III in Rome on Christmas Day, 800. The year 476, however, is a rather artificial division.[1] In the East, Roman imperial rule continued through the period historians now call the Byzantine Empire. Even in the West, where imperial political control gradually declined, distinctly Roman culture continued long afterwards; thus historians today prefer to speak of a "transformation of the Roman world" rather than a "fall of the Roman Empire." The advent of the Early Middle Ages was a gradual and often localised process whereby, in the West, rural areas became power centres whilst urban areas declined. With the Muslim invasions of the seventh century, the Western (Latin) and Eastern (Greek) areas of Christianity began to take on distinctive shapes. Whereas in the East the Church maintained its structure and character and evolved more slowly, in the West the Bishops of Rome (i.e., the Popes) were forced to adapt more quickly and flexibly to drastically changing circumstances. In particular whereas the bishops of the East maintained clear allegiance to the Eastern Roman Emperor, the Bishop of Rome, while maintaining nominal allegiance to the Eastern Emperor, was forced to negotiate delicate balances with the "barbarian rulers" of the former Western provinces. Although the greater number of Christians remained in the East, the developments in the West would set the stage for major developments in the Christian world during the later Middle Ages.
Conversion of barbarian hinterland
As the political boundaries of the Western Roman Empire diminished and then collapsed, Christianity spread beyond the old borders of the Empire and into lands that had never been Romanised.
Ireland and Irish missionaries
Beginning in the fifth century, a unique culture developed around the Irish Sea consisting of what today would be called Wales and Ireland. In this environment, Christianity spread from Roman Britain to Ireland, especially aided by the missionary activity of St. Patrick. Patrick had been captured into slavery in Ireland and, following his escape and later consecration as bishop, he returned to the isle that had enslaved him so that he could bring them the Gospel. Soon, Irish missionaries such as SS. Columba and Columbanus spread this Christianity, with its distinctively Irish features, to Scotland and the Continent. One such feature was the system of private penitence, which replaced the former practice of penance as a public rite.[2]
Anglo-Saxons (English)
Although southern Britain had been a Roman province, in 407 the imperial legions left the isle, and the Roman elite followed. Some time later that century, various barbarian tribes went from raiding and pillaging the island to settling and invading. These tribes are referred to as the "Anglo-Saxons", predecessors of the English. They were entirely pagan, having never been part of the Empire, and although they experienced Christian influence from the surrounding peoples, they were converted by the mission of St. Augustine sent by Pope Gregory the Great. Later, under Archbishop Theodore, the Anglo-Saxons enjoyed a golden age of culture and scholarship. Soon, important English missionaries such as SS. Wilfrid, Willibrord, Lullus and Boniface would begin evangelising their Saxon relatives in Germany.
The largely Christian Gallo-Roman inhabitants of Gaul (modern France) were overrun by Germanic Franks in the early 5th century. The native inhabitants were persecuted until the Frankish King, Clovis I converted from paganism to Roman Catholicism in 496. Clovis insisted that his fellow nobles follow suit, strengthening his newly-established kingdom by uniting the faith of the rulers with that of the ruled.
Netherlands and non-Frankish Germany
In 698 the Northumbrian Benedictine monk, St Willibrord was commissioned by Pope Sergius I as bishop of the Frisians in what is now the Netherlands. Willibrord established a church in Utrecht.
Much of Willibrord's work was wiped out when the pagan Radbod, king of the Frisians destroyed many Christian centres between 716 and 719. In 717, the English missionary Boniface was sent to aid Willibrord, re-establishing churches in Frisia and continuing to preach throughout the pagan lands of Germany. Boniface was killed by pagans in 754.
Early evangelisation in Scandinavia was begun by Ansgar, Archbishop of Bremen, "Apostle of the North". Ansgar, a native of Amiens, was sent with a group of monks to Jutland Denmark in around 820 at the time of the pro-Christian Jutish king Harald Klak. The mission was only partially successful, and Ansgar returned two years later to Germany, after Harald had been driven out of his kingdom. In 829 Ansgar went to Birka on Lake Mälaren, Sweden, with his aide friar Witmar, and a small congregation was formed in 831 which included the king's own steward Hergeir. Conversion was slow, however, and most Scandinavian lands were only completely Christianised at the time of rulers such as Saint Canute IV of Denmark and Olaf I of Norway in the years following AD 1000.
- 863 Saint Cyril and Saint Methodius sent by the Patriarch of Constantinople to evangelise the Slavic peoples. They translate the Bible into Slavonic.
Early Medieval Papacy
The city of Rome was embroiled in the turmoil and devastation of Italian peninsular warfare during the Early Middle Ages. Emperor Justinian I attempted to reassert imperial dominion in Italy against the Gothic aristocracy. The subsequent campaigns were more or less successful, and the Imperial Exarchate was established in Ravenna to oversee Italy, though actually imperial influence was often limited. However, the weakened peninsula then experienced the invasion of the Lombards, and the resulting warfare essentially left Rome to fend for itself. Thus the popes, out of necessity, found themselves feeding the city with grain from papal estates, negotiating treaties, paying protection money to Lombard warlords, and, failing that, hiring soldiers to defend the city.[3] Eventually, the failure of the Empire to send aid resulted in the popes turning for support from other sources, most especially the Franks.
Carolingian Renaissance
The Carolingian Renaissance was a period of intellectual and cultural revival during the late 8th and 9th centuries, mostly during the reigns of Charlemagne and Louis the Pious. There was an increase of literature, the arts, architecture, jurisprudence, liturgical and scriptural studies. The period also saw the development of Carolingian minuscule, the ancestor of modern lower-case script, and the standardisation of Latin which had hitherto become varied and irregular (see Medieval Latin). To address the problems of illiteracy among clergy and court scribes, Charlemagne founded schools and attracted the most learned men from all of Europe to his court, such as Theodulf, Paul the Deacon, Angilbert, Paulinus of Aquileia, and Alcuin of York.
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Cafe Spice Namaste Send to Phone
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Ippo Shining in Glory
Chapter Info
|Japanese Title:
|Romanized Title:
|Total Pages:
Chapter Chronology
|← Previous
|Next →
Ippo Shining in Glory is the eighty-seventh chapter of Morikawa Jouji's manga series Hajime no Ippo.
- Characters Introduced: None
- Locations Introduced: None
- Mentioned Boxers: None
- Title Page Character(s): Makunouchi Ippo
By defeating Mashiba, Ippo has now become the East Japan Rookie King. His coach and Yagi enter the ring to congratulate him on the victory, but they are interrupted by Mashiba who refuses to accept the decision. As Mashiba moves towards Ippo wanting to fight, Ippo responds by respectfully bowing and offering a hand shake. Mashiba in anger hits the floor repeatedly and then turns around and leaves the ring.
Later that night at the award ceremony for all the rookie kings of different weight classes, Ippo is awarded the "Most Talented Rookie Award".
In Mashiba's room, his sister feels bad about him boxing for her sake. She prepares to beg him to quit, but before she gets the chance, he states how much boxing draws him in and that he would not be able to stop.
Ippo, now ranked number ten by the Japanese Boxing Commission, and with the praise of all those who underestimated him, leaves the hall after his sixth victory.


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What is JotForm?
JotForm is a free online form builder which helps you create online forms without writing a single line of code. No sign-up required.
At JotForm, we want to make sure that you're getting the online form builder help that you need. Our friendly customer support team is available 24/7.
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How do I get the reply emails from Jotform to come to me from the repliers email rather than jotform?Asked by volrgnceo on October 22, 2013 at 12:21 PM
Emails com to me from jotform as email@example.com. I want them to come to me from the actual sender's address as it is captured on teh jotform questions.
Thank you for contacting us. We have a detailed guided that you can follow on how to change your email notification to the actual sender. Please use this link http://www.jotform.com/help/238-How-to-Add-a-Custom-Sender-Address-to-an-Email-Alert.
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I tried the solution and it did not work. When my team completes a jotform, I want the email from them to me to show their actual email address as the sender with me as the recipient. Right now, the sender is firstname.lastname@example.com. Using the solution above, I get my email as the sender and I am looking for theirs. Their email is the first field they fill in on the form. Is it possible to capture their email address as the sender? Thanks and great job on timely responses.
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AnibalRod Photographer Photographer
Tiffanie JewettModel Female Altamonte Springs, Florida, US
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Let us know when your receive great advice so we can thank our lawyers and point others with similar questions in the right direction.Got it!
If children use state subsidies to help pay their childcare tuition costs the out of pocket cost (OPC) for the custodial parent is significantly lower than if they did not use subsidies. The OPC for the parent is a % of their monthly income & the subsidy covers the rest of the childcare tuition. Once child support is established the OPC for the custodial parent will increase since their monthly income increases with the support. That leaves the child support calculation inaccurate since the total OPC will then increase and the parent owing support would then owe more (vicious cycle). When calculating the children's overall childcare costs can it be calculated as to what the children cost w/o subsidies in order to get a more accurate figure so that the amount does not continue to change?
No. Child support is not income to the receiving parent. A court will generally use the amount of childcare costs actually paid. In addition to using the reduced amount if you get a subsidy, the court can also subtract the tax benefit.
This answer is provided for general purposes only. If you need legal assistance you should consult with an attorney. If you wish to discuss the facts of your case with me, please feel free to contact my office via the information below. Please note that neither my response to your question nor your contacting of my office creates an attorney-client relationship. Christopher Tamms Tamms Law Office, LLC 6457 Reflections Drive; Dublin, Ohio 43017 Phone- 614-859-9529 firstname.lastname@example.com a similar question
It would be inappropriate to use the full amount of the child care cost to calculate child support because that is not the actual cost to the residential parent. If the change in the subsidy would be that significant after the receipt of the increased child support, then you can invest in having a representative of the subsidy program testify as to how the subsidy would be affected as the result of various levels of child support increases. Then the Magistrate would be able to factor the change in the subsidy into the support calculations and it would not be inappropriately determined. Otherwise, once the support is calculated, if the change in subsidy does not change the amount of support payable by more than 10%, the court will not re-calculate the support over again.
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Perfectly timed soccer team photo captures bench collapse
League of Ireland Premier Division team Derry City gathered together to take their team photo when something magical happened just as the camera went off: the bench the front row of players were sitting on collapsed.
The chances of something so hilarious being captured at such a perfect time must be extremely slim, so be sure and really drink in everything in the photo, from the confusion on the faces of the players on the bench to the joy in the eyes of their teammates standing behind them.
• Soccer Brawl Breaks Out; 12 Players Sent Off After Flying Kicks, Punches (Video)
Bench collapses during @derrycityfc cup final photo, leads to best team shot ever. pic.twitter.com/tSMVlVbXwy— Newstalk's Team 33 (@teamthirtythree) October 17, 2014
How the player all the way on the left wound up face down is the kind of mystery that elevates this from a goofy photo to high art.
- Brendan Maloy


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Louis Vuitton Mahina Galatea MM in Opal
Once upon a time, there was a very strange sculptor named Pygmalion. He carved a woman of incomparable beauty and named it Galatea. He dressed it with the most ravishing ornaments and showered it with the loveliest flowers. Every night he prayed to the goddess Aphrodite to turn the lifeless form into a real woman. His wish was granted. Just like Pygmalion's Galatea, the new Louis Vuitton Mahina Galatea is meant to be adorned and passionately wished for.
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Images via Louis Vuitton


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Auto Meter 3236 Stainless Line Kit for Pressure Gauges, -3 AN, 6 FT
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If you think general religion coverage is bad, try mixing it with media coverage of science. Then try to find a reporter who handles it well. It's almost impossible. Back when I started at GetReligion, I could have posted daily on the errors in coverage of what used to be an extremely hot-button topic — [Read More…]
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Master Po: Ha, ha, never assume because a man has no eyes he cannot see. Close your eyes. What do you hear? Young Caine: I hear the water, I hear the birds. Master Po: Do you hear your own heartbeat? Young Caine: No. Master Po: Do you hear the grasshopper that is at your feet? [Read More…]


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Shades of Pleasure
Smashwords Edition
Shades of Pleasure Copyright © 2012 by Circlet Press, Inc.
Cover Art Copyright © 2012 by Flexflex | Dreamstime.com
Published by Circlet Press, Inc.
39 Hurlbut Street
Cambridge, MA 02138
Smashwords Edition
This electronic version was produced in-house at Circlet Press and converted to multiple book fomats by the Smashwords Meatgrinder. Please report any problems you find with the ebook to us at email@example.com or by visiting the Bug Report section of our web site (www.circlet.com).
License Notes: Please do not support online piracy of copyrighted works. This ebook is licensed for the personal enjoyment of the purchaser only. This ebook may not be re-sold or given away to other people. If you would like to share this book with another person, please purchase an additional copy for each person you share it with. If you're reading this book and did not purchase it, or it was not purchased for your use only, or if you received this ebook copied from a friend or by other means, please support the writers who made it possible by purchasing a copy yourself. Thank you for your support.
Color of Pain, Shade of Pleasure


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The horizontal segment of the Tungolskoye No. 5 well has been drilled and completed in the J1-1 and J1-2 Upper Jurassic intervals. The total horizontal segment was just over 350 metres of which over 80% was located in the productive J1-1 and J1-2 reservoirs at depths between -2,502 m and -2,517 m TVD. The well is still cleaning up and current production is 604 bopd using an Electric Submersible Pump (ESP). The oil is currently being trucked 25 km to the Lineynoye central processing facility.
Development of the Tungolskoye oil field which is estimated to contain 20 mmbbls in 2P reserves will now proceed immediately. Contracts are currently being finalized for the 2015/16 Tungolskoye development drilling programme. The programme is expected to comprise five horizontal and up to six vertical wells. Drilling is expected to commence in April 2015 and will be completed in Q1 2016. Further details will be announced once the drilling contract is executed.
PetroNeft Resources plc
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NEW YORK (AP) -- Apprentice jockey Taylor Rice won four races at Aqueduct on Monday, including the $62,000 allowance feature aboard Abra.
Rice guided the 6-year-old gelding to a 5 1/4-length win over Bear's Spirit. The victory was a family affair. Abra is trained by Linda Rice, Taylor's aunt.
Abra, 2-5 favorite, earned his fourth win in 14 starts, paying $2.90, $2.30 and $2.10. The time was 1:05.05 for the 5 1/2 furlongs on the fast track.
Bear's Spirit returned $3.20 and $2.20 while Sokitumi Samurai paid $2.10 to show.


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Marey Power Gas 10L Digital Panel Tankless Water Heater
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LeBron James and the Miami Heat tip off the NBA's new season against the Boston Celtics Tuesday night (TNT, 7 PM ET).
Game On!'s Michael McCarthy went one-on-one went with TNT's Charles Barkley.
The Inside the NBA analyst held forth on the new season, James' critically-panned ESPN special, The Decision, and the dancing celebration of James, Dwyane Wade and Chris Bosh in Miami.
Has Miami Heat become the team to hate?
Outlook on new season: It's going to be a very interesting season. There's a bunch of good teams. I know everybody's going to jump on the (defending champion Los Angeles) Lakers bandwagon and the Heat bandwagon. But it's not going to be a cakewalk for them to get there. Either one of them...Miami's got a lot of questions about their depth. They've got three terrific players. But it takes a lot more than that. You have to stay (healthy). And you got to wonder at some point when Father Time is going to catch up with Kobe Bryant? The guy's hurt all the time. He's hurt all last season. Father Time is undefeated. You got to wonder at some point if its going to kick in. Oklahoma City (Thunder) and Utah (Jazz) are going to be real good in the West too...I like what (Miami) has done clearly. But Boston, Orlando (Magic) and Chicago (Bulls) are terrific in the East.
Who will be the leader of the Heat?: I think it's going to be LeBron. The leader's always the best player on any team. LeBron's the best player in the NBA. So it's his team.
On James calling out Barkley: No. 1, I did not get offended by (James) signing with the Heat. That's the biggest misconception. I made a mistake by using the word 'punk.' I thought that Decision thing was silly and I thought when they came out on stage, that was silly. I know the way the media works: they'd say I was calling LeBron a punk. Once it came out, I knew they would screw it up. It doesn't bother me. I made a mistake saying 'punk.' What I said was the Decision thing was silly, and when they came out on stage dancing around on stage, that was silly. Other than that I don't worry too much about what people think of what I say.
Are the Heat a team to hate?: I think LeBron's said some things that are really unfortunate. I think the only problem, myself included, have with this whole thing is how it was handled. I got no problem, no problem, with LeBron going to Miami. If you go back, I think most criticism has been about that Decision thing. I think he should have been more sympathetic to the fans (in Cleveland). He should have told the Cleveland Cavaliers in advance. That's No. 1. He should have taken their situation into account, to be honest with you. I really think that's where basically all the criticism came from, if you want to be realistic. It wasn't that people got mad he went to Miami. Just that Decision thing -- and how he handled it.
The role of racism in James' backlash: I did not think that. I've said that before, I did not believe that. Listen, let's get one thing straight. Other than the fact of how LeBron handled the situation going to Miami, I have not heard one person say anything bad about LeBron James. Myself included...It's no big deal he went to Miami. He was a free agent -- and he went there. Most of the criticism I've heard, and I've seen, has been about that Decision catastrophe and when they came out on stage dancing around. I have not heard anybody criticize LeBron. When we were at the Hall of Fame, Magic (Johnson), Michael (Jordan), Larry (Bird) and myself said we would not have went to Miami. That's just a basketball situation. That has nothing to do with anything, We just said we wanted to beat the other guy. That's not a criticism, that was just giving our opinion. My criticism, and the only criticism I've really heard about LeBron, is how he handled the situation. He should have been sympathetic to the people of Cleveland and just announced he was going to Miami. That's just a fact. That's not a criticism. That's just a fact. I have not heard anybody say LeBron was a bad guy. The only criticism has been about that Decision thing, that's really been the only criticism. That has nothing to do with race. He just should have handled that differently.
Pat Riley to the bench: I think it would be frowned up on in basketball circles if that happened. It happened one time with Stan Van Gundy. I think it's Erik Spoelstra's job right now. You can't really judge them by 3-4 games. It has to be how it turns out by the end of the year.
Political thoughts: I'm not thinking about politics right now because I think the system is so broken. This system, man, is just so bad right now. It's just a constant struggle between the Democrats and the Republicans...This political system is so broken right now. I just feel bad for the American people. It's a total joke right now.
Reid Cherner has been with USA TODAY since 1982 and written Game On! since March 2008.
He has covered everything from high schools to horse racing to the college and the pros. The only thing he likes more than his own voice is the sound of readers telling him when he's right and wrong.
Michael Hiestand has covered sports media and marketing for USA TODAY, tackling the sports biz ranging from what's behind mega-events such as the Olympics and Super Bowl to the sometimes-hidden numbers behind the sports world's bottom line.


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Collingwood said he was "surprised and baffled" by a call from Test legend Geoffrey Boycott for the coach to stand down with the Ashes just weeks away.
"I do not think you should blame the coach for our results," he said after the Champions Trophy loss to Australia. "The coach can give you as much advice as possible but it is the players who go out and make the decisions."
In his BBC Sport column, Collingwood disagreed with Boycott's suggestion there was a danger of 'stagnation' by sticking with one coach for too long.
"The game progresses every single year, as do theories and coaching techniques. Everything is getting faster," he said. "Duncan advances like the game does. Certainly his theories do."
Boycott picked out Collingwood, the most experienced player in England's current side with 102 one-day caps, as being too low in the batting line-up.
"He's never played so well, or been so confident. And where is he batting? Number six," Boycott wrote in the Daily Telegraph. "By the time Collingwood came in on Saturday the game was over, and there was nothing he could do but hang around with the tail-enders."
Collingwood responded: "It is only because I was stranded down the order in this one game that people think I'm wasted there. "You cannot set the batting order expecting to be five down after 10 overs."


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Buddy Holly Birthday
September 7, 2011 by staff
Buddy Holly Birthday, Today would have been the rock and roll 75 years of pioneer Buddy Holly. Wednesday, September 7, called Friends Holly Day with Holly to be honored on the Walk of Fame Hollywood in Los Angeles. His widow, Maria Elena Holly, agreed to star in his name next to two friends of Holly, producer Peter Asher, Phil Everly of the Everly Brothers, and actor Gary Busey. Busey portrayed Holly in the 1978 film "The Buddy Holly Story."
The singer and songwriter who was black geek glasses fashionable, had such classics as "Peggy Sue," "That will be the day", and "every day."
In a career spanning 18 months, the young rock sensation placed 10 hits on the Billboard Hot 100, with his band "The Crickets" and as a solo performer.
So his life ended tragically too soon in 1959 at the age of 22 in a plane crash, along with rock and roll great companions Ritchie Valens and Big Bopper.
Holly influence of the Beatles, Rolling Stones, and more recently the band Weezer, who wrote the tribute song "Buddy Holly" and many others.
When Don McLean heard of Holly's death, wrote his classic "American Pie", which describes how he felt at the time "of the music day of death."
To keep the music of Holly in the minds of younger generations, a new collection of his songs is disclosed, entitled "Listen to me:. Buddy Holly" Among the contributing artists who will perform the classic hits are Stevie Nicks Holly , Natalie Merchant, The Fray, Brian Wilson, Chris Isaak, Ringo Starr, and many others.
"We're trying to keep the name of Buddy Holly alive for younger generations can appreciate the way I do," says Brian The Beach Boys' Wilson. "Buddy is unique. He's important because his music is timeless." Wilson made his own interpretation of Holly "Listen."
So if you live in the U.S. or Canada, you can buy the album of 06 September. His fans around the world, we will unfortunately have to wait for later.
Please feel free to send if you have any questions regarding this post , you can contact on
Disclaimer: The views expressed on this site are that of the authors and not necessarily that of U.S.S.POST.


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Characteristics of progressive multifocal leukoencephalopathy clarified through internet-assisted laboratory surveillance in Japan
Demyelinating diseases
Progressive multifocal leukoencephalopathy (PML), a rare but fatal demyelinating disease caused by JC virus (JCV), occurs mainly in immunocompromised patients. As PML develops in individuals with various underlying disorders sporadically and infrequently, a nationwide survey of PML is difficult. This study was conducted to elucidate the characteristics of PML in Japan through an internet-assisted laboratory surveillance program.
A diagnostic support system for PML was established using a real-time PCR assay of JCV DNA in cerebrospinal fluid (CSF), and requests for testing were received from clinicians via specialized websites. Medical histories of patients were collected through standardized questionnaires, and a database of CSF JCV loads and clinical information was created and analyzed.
For 4 years from April 2007 to March 2011, CSF specimens from 419 patients were tested. Forty-eight individuals were found positive for JCV DNA in their CSF and were diagnosed with PML. PML primarily occurred not only in HIV-positive patients (33.3%) but also in patients with hematologic disorders after receiving stem cell transplantation, chemotherapy, and/or immunosuppressive treatment (39.6%). The frequencies of PML cases among the subjects in these two categories were 20.3% and 23.5%, respectively. Although no significant features were observed with respect to CSF JCV loads in PML patients with an HIV infection or hematologic disorder, males were predominant in both groups (100% and 89.5%, respectively). The proportion of PML cases with autoimmune disorders (6.3%) or solid-organ transplants (2.1%) was smaller than those with HIV infection or hematologic disorders, probably due to the limited availability of therapeutic monoclonal antibodies and transplantation from brain dead donors.
The results suggest that the internet-assisted laboratory surveillance program might be a useful strategy for collecting precise real-time information on PML on a national level. The current database provides important background information for the diagnosis and treatment of patients with risk factors for PML.
Progressive multifocal leukoencephalopathy (PML) is a rare but fatal demyelinating disease caused by JC virus (JCV), a small DNA virus belonging to the family
To conduct a nationwide survey of PML, the collection and analysis of large amounts of clinical data are necessary. However, as PML develops in patients with various underlying disorders sporadically and infrequently, a comprehensive surveillance of PML is difficult. Recent epidemiological data on PML were mainly obtained from retrospective cohort studies of HIV-infected persons
The detection of JCV DNA in cerebrospinal fluid (CSF) by PCR is a reliable and less-invasive marker for the diagnosis of PML
Clinical information on patients from whom CSF specimens were collected
This study was performed under informed consent from patients or their family members and with the approval of the Ethical Committee for Biomedical Science in the NIID. CSF testing for JCV DNA was requested from the patients' physicians for the diagnosis or management of PML primarily via two specialized web sites (available in Japanese language only), [
Real-time PCR testing for JCV DNA
Total DNAs were extracted from CSF specimens using a QIAamp DNA Blood Mini Kit (Qiagen, Valencia, CA) and subjected to real-time PCR assay as described previously
Additional file 1
Figure S1. Schematic diagram of the standard DNA and primer / probe sets for PCR testing. Yellow and grey lines represent the sequences of the JCV genome and pBR322 vector within the standard DNA (pJC1-4->pJCV), respectively. The numbers in the circle correspond to the nucleotide positions within the JCV genome. Three primer / probe sets detect the JCV T and VP1 genes and the boundary sequence of the JCV genome and pBR322 (green, red, and blue, respectively).
Click here for file
Additional file 2
Figure S2. Examples of real-time PCR amplifications. Three real-time PCR assays were designed to detect the JCV T (A) and VP1 (B) sequences and the contamination of samples with standard DNA (C). The reactions were performed in the absence or presence of standard DNA (2.0 x 108 to 0.8 copies per reaction). Relative fluorescence is plotted against cycle number. These PCR assays were capable of detecting at least 4 copies of JCV DNA per reaction under the same conditions. The data are representative of three independent experiments.
Click here for file
Statistical analysis
The proportions of JCV-positive or combination antiretroviral therapy (cART)-treated patients in each group were statistically compared by means of a two-tailed Fisher's exact test. For multiple testing, the resulting
Detection of JCV DNA in CSF specimens from patients
From April 2007 to the end of March 2011, 504 CSF specimens from 419 patients were submitted to the NIID for testing by hospitals in 43 of Japan's 47 prefectures (91.5%), with many requests received from the Tokyo metropolitan area and other regions with large populations (Figure
Figure 1
The geographical distribution patterns of the examined population (A) and PML patients (B)
The geographical distribution patterns of the examined population (A) and PML patients (B). All prefectures are colored based on the number of individuals.
Characteristics of PML patients with hematologic disorders or other underlying diseases
Having shown that PML is frequently seen in patients with hematologic disorders in Japan, the characteristics of these patients were compared to those of patients with HIV infection or other non-HIV-related diseases. The age and sex distributions of study population and PML patients are shown in Figure
Figure 2
The age and sex distribution patterns of the study population (A) and PML patients (B)
The age and sex distribution patterns of the study population (A) and PML patients (B). The subjects and PML patients were divided into three groups on the basis of HIV infection, hematologic disorders, or other underlying diseases including autoimmune disorders. The vertical axes indicate the number of individuals. The solid and open bars show the results for males and females, respectively. The numbers of below the bars represent 10-year age groups (e.g., "0" indicates individuals aged 0 to 9). The data exclude 1 HIV-positive subject whose age was not known.
Figure 3
The JCV DNA levels in the CSF specimens from PML patients
The JCV DNA levels in the CSF specimens from PML patients. The CSF viral loads for patients with HIV infection, hematologic disorders, or other diseases are shown (left to right). The open circles indicate the copy number of JCV DNA in each sample, and the horizontal lines represent the medians. In several cases, JCV DNA measurement was performed for different specimens from the same patient during the follow-up period.
Medical history of PML patients with hematologic disorders
The final set of analyses was conducted to assess the clinical background of PML patients with hematologic disorders. The practice of hematopoietic stem cell transplantation (HSCT) in patients found to be positive or negative for JCV DNA on the basis of CSF specimens is shown in Table
The present study clarified the characteristics of PML cases in Japan based on clinical data obtained through the laboratory testing for JCV DNA in CSF specimens. Mass screening of PML patients has not been feasible in Japan due to the lack of a suitable database for PML. The current strategy deals with a relatively small number of patients but has a distinct advantage in collecting precise real-time information for patients as well as specimens. The testing was constantly requested by the physicians via websites, despite the fact that there were at least 4 commercial laboratories providing similar assays during the study period according to our own survey. Thus, this internet-based approach is thought to be useful for sampling data for rare infectious diseases. In addition, as this diagnostic support system was conducted regardless of patient age, gender, underlying disease or medical history, precise information could be obtained not only from PML patients but also from CSF-JCV-negative individuals with similar conditions. These data are considered to be valuable for the examination of the overall background to PML in Japan.
A large number of PML patients had HIV infection / acquired immunodeficiency syndrome (AIDS) or hematologic disorders. Recent database analyses and other clinical studies in the USA have suggested that approximately 79–82% of PML patients are positive for HIV and 7.7–13% have hematological malignancies
A notable finding of the present study is that hematologic disorders are a main risk factor for PML in Japan. Five of 19 patients in this group had received allogeneic HSCT, suggesting that this type of transplantation is an important risk factor of PML. In the other 14 PML cases, 11 individuals (patients 6–16) were administrated with chemotherapeutic and / or immunosuppressive agents for the treatment of hematologic malignancies. Thus, it is likely that these therapies are associated with the high incidence of PML cases in this category. The present study also demonstrates that the majority of PML patients with hematologic disorders are males. In contrast, the percentages of male patients with hematologic malignancies were similar to or slightly higher than those of females (leukemia, 59.1%; lymphoma, 52.9%; MM, 52.1%) according to the most recent statistics from the National Database for Cancer Incidence in Japan
In 50 subjects with autoimmune disorders, 3 SLE patients were diagnosed as having PML. These patients had been treated with immunosuppressive agents, such as tacrolimus, mesalazine, mycophenolate mofetil, prednisolone, and / or cyclophosphamide, but not with therapeutic antibodies. No PML cases were observed among individuals with other types of autoimmune disorders. In Japan, natalizumab and efalizumab are not currently approved for use, and rituximab is not licensed for the treatment of autoimmune disorders. Therefore, increased awareness may be needed about the potential for PML in accordance with the wide spread use of therapeutic monoclonal antibodies in this country. It was also shown that the occurrence of PML is uncommon in individuals receiving solid-organ transplantation. Among the total study population, only 10 subjects underwent kidney, liver, or heart transplantation, and PML developed in one liver-transplanted patient. As this patient had suffered from common variable immunodeficiency, the association between the transplantation and PML remains unclear. This situation can be explained by the limited number of patients, who underwent organ transplantation, especially from brain dead donors
The results of this study suggest that the internet-assisted laboratory surveillance system might be a useful strategy for elucidating the characteristics of PML on a national level. The present database provides important background information for the diagnosis and treatment of patients with risk factors for PML in Japan.
PML: Progressive multifocal leukoencephalopathy; JCV: JC virus; HIV: Human immunodeficiency virus; SLE: Systemic lupus erythematosus; CSF: Cerebrospinal fluid; NIID: National institute of infectious diseases; MRI: Magnetic resonance imaging; VP1: Viral protein 1; cART: Combination antiretroviral therapy; CD4: Cluster of differentiation 4; AA: Aplastic anemia; MM: Multiple myeloma; HSCT: Hematopoietic stem cell transplantation; AML: Acute myeloid leukemia; ALL: Acute lymphoblastic leukemia; HL: Hodgkin's lymphoma; NHL: Non-Hodgkin's lymphoma; AIDS: Acquired immunodeficiency syndrome.
Competing interests
The authors declare that they have no competing interests.
Authors' contributions
KN conceived of the study, carried out real-time PCR testing, and created the database of patients. KN and MS analyzed the clinical data and drafted the manuscript. HM and MY supervised the PML surveillance program in Japan. SK and YM participated in the clinical study of PML cases. TS performed the statistical analyses. TT supported the internet-assisted support system for JCV testing. HM, MY, SK, YM, TS, TT, CKL, and IK participated in the study design and coordination, and helped to draft the manuscript. All authors read and approved the final manuscript.
The authors are grateful to all study participants and physicians who contributed to the present study. The authors are also indebted to Drs. Yutaka Takebe (NIID), Kazuo Nagashima (Sapporo Higashi-Tokushukai Hospital), Hirofumi Sawa (Hokkaido University), Souichi Nukuzuma (Kobe Institute of Health), Yukiko Shishido-Hara (Kyorin University), Motohiro Yukitake (Saga University), and Kozue Tanaka (Tokyo Metropolitan Cancer and Infectious diseases Center Komagome Hospital) for supporting the establishment of the PML surveillance system and for their valuable comments, and suggestions for this study. This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science, Sports and Culture of Japan [22790446] and by those for the Research Committee of Prion disease and Slow Virus Infection [H22-Nanchi-Ippan-013], the Research for Intractable Infectious Diseases in Organ Transplant Recipients [H21-Shinko-Ippan-009], and the Research on HIV/AIDS (H24-AIDS-Wakate-002) from the Ministry of Health, Labour and Welfare of Japan.
Progressive multifocal leukoencephalopathy and other forms of JC virus disease
Progressive multifocal leukoencephalopathy and other disorders caused by JC virus: clinical features and pathogenesis
Progressive multifocal leukoencephalopathy and promyelocytic leukemia nuclear bodies: a review of clinical, neuropathological, and virological aspects of JC virus-induced demyelinating disease
Population-based study of antibody to the human polyomaviruses BKV and JCV and the simian polyomavirus SV40
Pathogenesis of progressive multifocal leukoencephalopathy-revisited
Antiretroviral therapy CNS penetration and HIV-1-associated CNS disease
HIV-associated central nervous system diseases in the recent combination antiretroviral therapy era
Spectrum of intracranial parenchymal lesions in patients with human immunodeficiency virus infection in the Republic of Korea
Incidence, clinical presentation, and outcome of progressive multifocal leukoencephalopathy in HIV-infected patients during the highly active antiretroviral therapy era: a nationwide cohort study
Influence of HAART on the clinical course of HIV-1-infected patients with progressive multifocal leukoencephalopathy: results of an observational multicenter study
Human immunodeficiency virus-associated progressive multifocal leucoencephalopathy: epidemiology and predictive factors for prolonged survival
Central nervous system infections in HIV-infected patients hospitalized at King Chulalongkorn Memorial Hospital
Aids-related progressive multifocal leukoencephalopathy: a retrospective study in a referral center in Sao Paulo, Brazil
Clinical outcome of long-term survivors of progressive multifocal leukoencephalopathy
Incidence and outcome of progressive multifocal leukoencephalopathy over 20 years of the Swiss HIV Cohort Study
Pharmacovigilance and PML in the oncology setting
Clinical outcomes of natalizumab-associated progressive multifocal leukoencephalopathy
Progressive multifocal leukoencephalopathy associated with efalizumab use in psoriasis patients
A Swedish national post-marketing surveillance study of natalizumab treatment in multiple sclerosis
An integrated safety profile analysis of belatacept in kidney transplant recipients
Swedish natalizumab (Tysabri) multiple sclerosis surveillance study
Natalizumab-associated progressive multifocal leukoencephalopathy in patients with multiple sclerosis: lessons from 28 cases
Progressive multifocal leukoencephalopathy after rituximab therapy in HIV-negative patients: a report of 57 cases from the research on adverse drug events and reports project
Incidence of progressive multifocal leukoencephalopathy in patients without HIV
Progressive multifocal leukoencephalopathy deaths in the USA, 1979–2005
Progressive multifocal leukoencephalopathy: a national estimate of frequency in systemic lupus erythematosus and other rheumatic diseases
Progressive multifocal leukoencephalopathy and use of mycophenolate mofetil after kidney transplantation
Evaluation of a quantitative real-time PCR assay for the detection of JC polyomavirus DNA in cerebrospinal fluid without nucleic acid extraction
Cloned human polyomavirus JC DNA can transform human amnion cells
Controlling the false discovery rate: a practical and powerful approach to multiple testing
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 14–2004. A 66-year-old man with progressive neurologic deficits
Annex 1 - HIV and AIDs estimates and data, 2009 and 2001
Cancer incidence and incidence rates in Japan in 2006: based on data from 15 population-based cancer registries in the monitoring of cancer incidence in Japan (MCIJ) project
Current status of organ transplantation in Japan
New organ transplant policies in Japan, including the family-oriented priority donation clause
Pre-publication history
The pre-publication history for this paper can be accessed here:


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David Noel will compete in the nationally-televised College Slam Dunk Contest this Thursday in Indianapolis. Noel wowed the Tar Heel faithful with his high-flying performances for four years in Chapel Hill, but he was far more than a dunker. Noel earned second-team All-ACC honors in leading UNC to its surprising second-place finish in the ACC and top-ten national ranking. (Inside Carolina)
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