text:
Here is a collection of Xu Zhu's weapons in the Warriors series.
Dynasty WarriorsEdit
Dynasty Warriors 3Edit
Dynasty Warriors 3: Xtreme LegendsEdit
|Earthly Mace
|Weapon Level: 5
|Hits: 6
|Base Attack: 50
|Fire (C4)
|Speed: 24
|HP Max: 82
|Defense: 55
|Bow Defense: 50
|Meat Bun Recovery: 14
Dynasty Warriors 4Edit
Level 10 Weapon AcquisitionEdit
- Stage: Battle of Tong Gate
- Requirements: Get Han Sui to defect to your side by defeating the four generals in the southeast land and beating his officers. Next, defeat Pang De then eliminate Ma Dai after that. Finally, eliminate Chen Yi.
Dynasty Warriors 4: Xtreme LegendsEdit
|Earth Shaker
|Base Attack: 53
|Number of Hits: 6
|Peacock Urn: 14
|Speed Scroll: 20
|Wing Boots: 19
|Seven Star Sash: 16
Level 11 Weapon AcquisitionEdit
- Stage: Village Encounter
- Restrictions: No bodyguards
- Defeat Yu Jin and his supply troop captain.
- Defeat Li Dian and his supply troop captain.
- Defeat Dian Wei's three supply troop captains, defeat Dian Wei.
- Defeat Yue Jin before the disaster spreads, defeat his supply troop captain.
- Defeat Dian Wei's three supply troop captains, then defeat Dian Wei for a second time.
- Defeat Man Chong and his supply troop captain before the disaster spreads.
- Level 11 message.
Note: It's okay to let them start plundering. Just make sure you kill the officer and his supply captain before the disaster spreads. It's okay to let the three supply captains who appear with the third Dian Wei flee. Just make sure you kill Man Chong.
Dynasty Warriors 5Edit
Fourth Weapon AcquisitionEdit
- Stage: Battle of Tong Gate (Wei)
- Location: River west of where the player started.
- Requirements: Defeat Pang De and Ma Chao.
Dynasty Warriors 6Edit
|Bone Crusher
|Weapon Type: Standard
|Chaos Crusher
|Weapon Type: Strength
|Whirlwind Crusher
|Weapon Type: Skill
Dynasty Warriors: StrikeforceEdit
Xu Zhu uses cudgels as his main weapon in the game.
Dynasty Warriors 7Edit
Xu Zhu uses the club as his default weapon in the game and its various spin-offs.
Dynasty Warriors NextEdit
|Base Attack: 30+
|Number of Hits: 4~5
|Spiked Club
|Base Attack: 40+
|Number of Hits: 5~6
|Stone Crusher
|Base Attack: 50+
|Number of Hits: 6
Dynasty Warriors 8Edit
Xu Zhu still uses the club as his default weapon in this title.
Dynasty Warriors: GodseekersEdit
Warriors Orochi 1 & 2Edit
|Weapon Level: 1
|Base Attack: 11
|Spiked Club
|Weapon Level: 2
|Base Attack: 23
|Bone Crusher
|Weapon Level: 3
|Base Attack: 46
|Stone Crusher
|Weapon Level: 4
|Base Attack: 92
Warriors Orochi 3Edit
|Hex Club
|Base Attack: 8
|Compatibility Bonus: 7
|Studded Club
|Base Attack: 12
|Compatibility Bonus: 11
|Stone Crusher
|Base Attack: 21
|Compatibility Bonus: 14
|Holy Comet
|Base Attack: 36
|Compatibility Bonus: 18
Big Star WeaponsEdit
Xu Zhu uses the following big star weapons in the game.
- Hammer of Destruction
- Puncturer
- Kiritanpo
- Disintegrator
- Scooper (DLC)
Warriors Orochi 3 UltimateEdit
|Holy Comet X
|Base Attack: 72
|Compatibility Bonus: 18
|Mystic Crusher
|Base Attack: 66
|Compatibility Bonus: 18
Acquiring Mystic WeaponEdit
- Chapter 3: Siege of Tong Gate - Defeat Nosean and Goldenrod in under 5 minutes.
- Chapter 3: Ambush at Tong Gate - Defeat Zhang He, Deng Zhong, and 500 enemies in under 5 minutes.


text:
With Balance+ solution, USSD balance check service is now a promotional channel in UMS!
Tags : Balance+, UMS, USSD, Uzbekistan
Comments : 0
Thanks to the innovative and effective solution Balance+, UMS Uzbekistan subscribers now receive personalized promotional offers at each balance request. Advanced targeting and rotation settings allow to select potentially interesting to subscribers services and achieve a high... Read More

subset: commoncrawl


text:
|Message view
|« Date » · « Thread »
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|Sylvain Wallez <sylvain.wal...@anyware-tech.com>
|Re: [RT] Woody dynamic widgets design
|Thu, 11 Sep 2003 22:28:16 GMT
Timothy Larson wrote: <snip/> >Well, that is the preliminary view. Before the design gets finished and coded, >what do others think of this? Am I on the right track? What could be done better? > > Quick answer on the union : I very much like it, and actually was about proposing something similar. We just need to add datatype, label and all the usual stuff to the <union> widget to allow automatic generation of switchable panels (like in Woody's flowscript demo). Sylvain -- Sylvain Wallez Anyware Technologies http://www.apache.org/~sylvain http://www.anyware-tech.com { XML, Java, Cocoon, OpenSource }*{ Training, Consulting, Projects } Orixo, the opensource XML business alliance - http://www.orixo.com
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text:
A solution to Broome's affordable housing shortage?
As more major resource projects are earmarked for the north-west of Western Australia, housing availability and affordability has emerged as a key issue.
But a new joint-venture between the state government and the Shire of Broome might hold the key to providing permanent accommodation to workers in the Kimberley.
With work to start in 2012, the proposed subdivision in Broome's Cable Beach would see between 40 and 60 new lots developed, a quarter of which would be used for council staff accommodation.
The shire president Graeme Campbell says the subdivision could be vital in ensuring Broome's future.
He says the town has been steadily growing, even before the resource industry boosted the local population.
Mr Campbell says the lack of affordable housing is a growing concern, particularly for lower paid workers.
"Looking at the demographics, Broome's had a growth rate well in excess of three per cent for the past 20 years," he said.
"I'm not saying Broome's going to boom or bust or whatever, I just like to see a nice steady slow growth rate in housing.
"There are other councils that have developed small developments. But not on this scale and not with the joint venture basis."
Dire need
Ian Carter from Anglicare says more local governments need to become involved in creating housing.
Mr Carter was the chairman of the State Government's Social Housing Taskforce, which identified the dire need for more affordable housing across the state.
The result of that taskforce was the release last year of the government's public housing plan for the next decade.
He says the plan is off to a good start, with just over 20 per cent of the planned 20,000 homes needed by 2020 having already been built.
But Mr Carter warns a lot more work is still needed.
"A lot of people need to come to the table to deliver the outcomes we need," he said.
"And the public sector, the private sector and the community sector need to be doing far more than they are currently doing."
"There's better planning on on now. Certainly in the North west - Karratha, Kununurra, Broome - where there's unbelievable pressure on the housing market.
Broome shire's Graeme Campbell says affordable housing is one of the keys to maintaining the town's 'liveability'.
"You've only got to look at our neighbours up at Derby or go south of here and you know what the problem is," he said.
"There are a lot of NGOs in this town that are doing great work but always, just like the Shire, [they] suffer from lack of housing for people here to do the work."
One of those organisations is Foundation Housing, which recently completed a refurbishment of the old Broome Motel.
That project will provide 29 self-contained studio apartments and 26 ensuited lodging rooms for low-income workers in the town.
"That's exactly the sort of people we're trying to help," says Foundation Housing's Chris Milne.
"It might be a check out person in the supermarket. It might be a bus driver. It might be a person who works at the airport. It might be a hairdresser," he said.
Mr Milne says being able to offer low-paid workers better job opportunities is vital in helping them progress along the so-called 'housing continuum'.
"If some of those people were able to take that next job, at a slightly higher income, and move into affordable housing, then you're also going to empty out one of those public houses for someone else to move into as well."
High prices
Mr Milne says the rental value of housing in the north-west of the state is going up.
"Local agents have advised us over the past 12 months, rental prices have gone up about $100 dollars across the board," he said.
"The example that everyone points to is the Pilbara, where four bedroom homes cost $2,000 a week to rent.
"And that means it's only the highly paid workers who have housing provided by their employers tend to live there."
Mr Carter says affordable housing is an essential foundation of a sustainable community.
"For me, the issue about housing and ensuring everyone's got stable and affordable housing, is a fundamental priority of our community.
"There is land out there. There is the capacity to fund this creatively and otherwise. We need to be making the investment so more and more people have access to quality and affordable housing.
"There are far to many people at the moment who are missing out."
Graeme Campbell says the Cable Beach housing development will help ease housing stress for lower paid workers.
"These are the sort of people that get lost in the transition if the rents substantially go up."
"Our capacity to handle the growth into the future - with or with out oil and gas - is limited by staff being able to find, particularly at the bottom end of the staffing arrangement, housing.
"If we don't have the people to provide the services you don't have the services and you don't have the community."
Topics: housing-industry, housing, broome-6725
First posted


text:
Pinup Artist Nicole Artist/Painter
John RoachPhotographer Male Dallas, Oregon, US
My Website: My Pinup Art company
Mayhem # 148339
About Me
More about me below, but here are some current projects we are always needing fresh faces for. I currently produce live events, and we are always looking for cosplayers, models, etc for the shows. Here are the current upcoming shows:
Scream & Ink: Tattoo, Horror, Pin-Up - November 21-22, 2015 - Salem, OR - www.ScreamAndInk.com (seeking models for pin-up/horror fashion show and for Miss Scream & Ink contest as well as entrants for the tattoo contest. Also seeking guest celebrity models)
Cherry City Comic Con - April 30-May1, 2016 - Salem, OR - www.CherryCityComicCon.com (Cosplayers and costume contest)
Emerald Valley Comic Fest - 3rd Quarter 2016 - Eugene, OR - www.EmeraldValleyComicFest.com (Cosplayers and costume contest
My wife is a featured artist at many Comic Cons. We may have time to shoot some reference for one of her upcoming paintings. Let me know if you are interested in being art! We are always open for new ideas.
Her current schedule can be seen here: http://www.nicolebruneillustrations.com … -schedule/
I have been shooting for about 10 years now. Originally I trained under a tier 2 playboy photographer and have since been published in magazines, print ads, etc. I have shot just about every style, but usually my glamor style shots are whats asked for. I really like a challenge so if you have an idea but don't know how to do it, then that sounds like fun to me!
Have you worked with John Roach? Add Credits for John Roach! >>
Pinup Artist Nicole Artist/Painter
Nikki Christian Model
Emily Addison Model
ashleigh star Model
Megan_Renee Model
April- Model
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text:
The Lung Grendels are a genetic breed by Grendel Man. The name comes from a type of Chinese dragon.
They a peaceful race who will tend to take their anger out on machinery. While being able to breathe underwater, they don't have any tendency to go into it.
They mainly prefer seeds and fruit, but will sometimes eat critters. They also use critters to get rid of boredom.
The most unusual thing about the lung grendels is the fact they are able to fly (with an included agent).
They can be downloaded here.


text: Also, if you wanna see what the waves at ucsb have to offer, watch this cam on the link below on tuesday the 2nd and weds the 3rd. this is campus point (hint: its on campus). surfline is calling for for 4 to 6 and swellinfo predicts chest high. the sites always underforecast santa barbara though.


text:
On a day where eleven wickets fell, Mumbai gave their opponents an uphill task of scoring 359 runs in 172 minutes and 15 mandatory overs for an outright win and become the second team from Group 'A' to make it to the semi-finals.
Mumbai, with 20 points to their credit had already made it to the last four stage while Punjab with eleven points are in the second position while Railways with ten points are breathing down Punjab's neck.
Mumbai in their last league match take on Punjab from December 25-28 while Railways take on Baroda at Vadodara on same dates in their last league encounter.
Resuming at their overnight second innings score of 82 for three, the hosts progressed quite well with Test discard Vinod Kambli playing a cameo innings of 64 runs off 129 balls including seven fours in the highest partnership of 97 runs with Amol Muzumdar (28 off 118 balls) for the fourth wicket off 37.4 overs.
But once the stylish southpaw was caught by Amit Pagnis off offie Kulmani Parida, Mumbai started losing wickets at regular intervals. Infact the champions lost their last six wickets for just 43 runs off 23 overs and were all out eight minutes after lunch with Parida (three for 39) causing most of the damage.
Another off-spinner Shreyas Khanolkar (three for 19) and J P Yadav (four for 41) were the other wicket takers for the visitors.
Meanwhile in New Delhi, a fine century by opener Rajat Bhatia helped the hosts grab the first innings lead against Kerala and gain two crucial points to stay alive in Elite Group A.
Replying to Kerala's first innings total of 371, Delhi ended the match at 375 for six with Bhatia's 104, compiled in more than six hours with the help of six boundaries and a six, playing a pivotal role.
Delhi now has six points from as many matches and will take on Andhra in an away match in the seventh and final round of the league stage.
Resuming at 108 for no loss, Delhi suffered an early setback when Gautam Gambhir departed for 78, an addition of 17 to his overnight score. Gambhir was caught by C M Deepak off medium-pacer Prashant Chandran.
Vijay Dahiya joined Bhatia and the two took the team total to 204 before Dahiya (36) was dismissed by veteran leg-spinner K N Ananthapadmanapbhan.
Skipper Mithun Manhas then joined Bhatia and the duo added 51 runs for the third wicket. But Kerala succeeded in breaking the stand when Sreekumar Nair clean bowled Manhas (29).
The visitors soon picked up their fourth wicket when Bhatia, caught by Deepak off Sreeshant, departed after his 370 minute vigil at the crease.
However, Kerala's hopes to capture a few more wickets and restrain Delhi did not work out as Ajay Jadeja (60) and Varun Kumar (30) steered them closer to the Kerala's total.
Powar's century puts Mumbai on top
Kerala continues to frustrate Delhi
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text: PointCasino Sportsbook to revisit bonus theft cases By SBR Tuesday, July 9, 2013 Share with: PointCasino Sportsbook (SBR rating D) has vowed to revisit the outstanding cold cases submitted by players earlier in the year. PointCasino players filed complaints alleging that their winnings were confiscated after the sportsbook retroactively amended their bonus terms to restrict certain types of wagers. At the time, PointCasino refused to change their ruling. SBR reported on March 3 that a PointCasino player had $1,000 confiscated. The player was accused of violating bonus terms by placing a single multiple (parlay) bet. Like other players, he stated that at the time of registration no such rule was listed outlawing multiple bets. On February 12, SBR reported that two PointCasino players had winnings confiscated for betting on the total goals of a match, as well as betting in excess of their deposit amount. SBR posted a screenshot provided by one of the players which appeared to verify their claim that PointCasino amended the bonus terms and conditions. PointCasino defended their confiscations in a terse statement to SBR which made no mention of the allegations of their retroactively altered terms. In all of the above examples, PointCasino not only confiscated bonuses, but all winnings derived from the bonuses, zeroing out player accounts down to the starting deposit. Sportsbook Review.com expands on the PointCasino cases in today's SBR Industry News Video: Follow SportsbookReview.com on twitter. SBR has been the leading online sportsbook industry watchdog since 1999. Players in need of assistance should submit a sportsbook complaint form. Players with general questions may also contact SBR by writing to firstname.lastname@example.com


text:
We help you find a Swaffham melodeon tutor. Melodeon tuition are an excellent method to learn a fun new hobby, pick up a new talent and gain confidence with melodeon. Try our site to search for Swaffham melodeon teachers and select which matches your requirements so you can start your melodeon tuition in Swaffham today!
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text:
Parex Resources Inc. announces its 2015 full year guidance.
Key highlights:
2015 average production range of 28,500-30,000 barrels of oil per day (bopd) as compared to the 2014 average of approximately 22,300 bopd and the 2013 average of 15,854 bopd;
Top quartile production growth of 30% year-over-year and 17% per basic share using mid-point guidance from 2014 and 2015;
2015 capital budget utilizes a Brent oil price of $85/barrel (bbl) that generates high operating netback production which provides for a capital program fully funded from cash flow;
Lower risk development and appraisal program plus facilities on existing discoveries of 16 gross wells (9.4 net) costing approximately $145 million. We expect this maintenance capital will allow us to sustain our Q4 2014 guidance mid-point production base of approximately 26,000 bopd;
Parex Resources Inc.
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Schlumberger has announced an agreement to acquire a majority (51%) equity interest in Eurasia Drilling Company Limited.
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text:
Docosahexaenoic Acid Therapy of Experimental Ischemic Stroke
We examined the neuroprotective efficacy of docosahexaenoic acid (DHA), an omega-3 essential fatty acid family member, in acute ischemic stroke; studied the therapeutic window; and investigated whether DHA administration after an ischemic stroke is able to salvage the penumbra. In each series described below, SD rats underwent 2 h of middle cerebral artery occlusion (MCAo). In series 1, DHA or saline was administered i.v. at 3, 4, 5, or 6 h after stroke. In series 2, MRI was conducted on days 1, 3 and 7. In series 3, DHA or saline was administered at 3 h, and lipidomic analysis was conducted on day 3. Treatment with DHA significantly improved behavior and reduced total infarct volume by a mean of 40% when administered at 3 h, by 66% at 4 h, and by 59% at 5 h. Total lesion volumes computed from T2-weighted images were reduced in the DHA group at all time points. Lipidomic analysis showed that DHA treatment potentiates neuroprotectin D1 (NPD1) synthesis in the penumbra 3 days after MCAo. DHA administration provides neurobehavioral recovery, reduces brain infarction and edema, and activates NPD1 synthesis in the penumbra when administered up to 5 h after focal cerebral ischemia in rats.
KeywordsFocal ischemia Magnetic resonance imaging Neuroprotection Animal models
Each year, over 15 million people worldwide suffer a stroke, many of which are ischemic [1]. Thrombolysis is the only treatment for ischemic stroke, but due to its narrow therapeutic window and complexity of administration, only 3–5% of patients benefit from this therapy [2]. Focal cerebral ischemia produces a brain lesion composed of an irreversibly injured core and a peripheral zone (penumbra), where tissue is damaged but potentially salvageable [3]. The penumbra has a limited life span and appears to undergo irreversible damage within a few hours unless reperfusion is initiated and/or neuroprotective therapy is administered [4].
Docosahexaenoic acid (DHA; 22:6, n-3) is an essential omega-3 fatty acid concentrated in membrane phospholipids of the central nervous system [5]. DHA is a natural element of our diet and is found in cold water fatty fish, including salmon, tuna, mackerel, sardines, shellfish, and herring. DHA has been shown to be involved in brain and retinal development, aging, memory formation, synaptic membrane function, photoreceptor biogenesis and function, and neuroprotection [6, 7, 8]. The recent identification of the protective docosanoid neuroprotectin D1 (NPD1; 10R,17S-dihydroxy-docosa-4Z,7Z,11E,13E,15Z,19Z-hexaenoic acid) in brain ischemia reperfusion [9], as well as in neural cells exposed to oxidative stress [10, 11, 12], has uncovered a key survival-signaling event leading to neuroprotection. NPD1 is a pleiotropic modulator of inflammation resolution [13]. Moreover several reports show that DHA is protective in ischemia [3, 7] and in spinal cord injury [14]. However, the mechanism/s and bioactive mediator/s involved - and particularly whether or not these mechanisms/mediators target the salvageable area of the stroke penumbra - have not yet been defined. In addition, the effect of systemic administration of DHA on the ischemic brain penumbra has not been explored.
Recently, we have shown that DHA therapy in low and medium doses improves neurological and histological outcome following focal cerebral ischemia [15]. The present study investigated the therapeutic window of DHA treatment in focal cerebral ischemia in rats. In addition, we studied whether administration of DHA after an ischemic stroke is able to salvage the penumbra. We used non-invasive magnetic resonance imaging (MRI) and LC-MS/MS-mediator lipidomic analysis in conjunction with behavioral, histological, and immunostaining methods to expand our understanding of this novel therapeutic approach. No prior studies have used MRI to evaluate the temporal effects of DHA treatment on brain ischemia.
Materials and Methods
Surgical Preparation
All studies were approved by the Institutional Animal Care and Use Committees of the Louisiana State University Health Sciences Center and Loma Linda University. Male Sprague–Dawley rats (Charles River Lab., Wilmington, MA) weighing 279–340 g were fasted overnight but allowed free access to water. Anesthesia was induced with 3.5% isoflurane in a mixture of 70% nitrous oxide and 30% oxygen. All rats were orally intubated and mechanically ventilated. Temperature probes were inserted into the rectum and the left temporalis muscles to maintain temperatures at 36–37°C during surgical procedures. The right femoral artery and vein were catheterized for blood sampling for arterial gases, pH, plasma glucose, and drug infusion.
Transient Middle Cerebral Artery Occlusion
Rats underwent 2 h of right middle cerebral artery occlusion (MCAo) by an intraluminal filament, coated with poly-L-lysine as previously described [16]. After 2 h of MCAo, rats were reanesthetized with the same anesthetic combination and intraluminal sutures were carefully removed.
Behavioral Tests
Behavioral tests were performed by an observer blinded to the treatment groups at 60 min (during MCAo) and then on days 1, 2, 3, and 7 after MCAo. The battery consisted of the postural reflex test and the forelimb-placing test to visual, tactile, and proprioceptive stimuli. Neurological function was graded on a scale of 0–12 (normal score = 0; maximum score = 12), as previously described [16].
In each series described below, rats underwent 2 h of MCAo. DHA (5 mg/kg) was dissolved in saline and administered intravenously at a constant rate over 3 min using an infusion pump according the study protocol. Vehicle-treated rats received an intravenous infusion of a comparable volume of 0.9% sodium chloride.
Study Protocols
In series 1 (therapeutic window study), DHA was administered i.v. at either 3, 4, 5 or 6 h after onset of stroke (n = 6–7 per group). Vehicle group received saline at 3 h after onset of stroke. Behavioral testing was conducted on days 1, 2, 3, and 7 followed by histopathology on day 7. In series 2 (MRI study), DHA (n = 5) or saline (n = 4) was administered at 3 h after onset of stroke and MRI was conducted on days 1, 3, and 7. In series 3 (lipidomic study), DHA or saline was administered at 3 h (n = 5–6 per group) and lipidomic analysis was conducted on day 3.
Magnetic Resonance Imaging
Rats were anesthetized with isoflurane and imaged on a Bruker Avance 4.7T MRI (Bruker Biospin, Billerica MA) as previously described [17]. A thermostat-controlled heated water cushion maintained body temperature at 36–37°C and respiration was monitored using a pneumatic cushion (Biopac Model 150, Goleta CA).
Image Analysis
T2 and apparent diffusion coefficient (ADC) maps were computed from T2-weighted imaging (T2WI) and diffusion-weighted imaging (DWI), respectively, as previously described [17]. Three-dimensional images were obtained to delineate the volumetric development of ischemic injury. Analysis included extraction of lesion, non-lesioned brain, and total brain volumes. Region of interest (ROI) was drawn semi-automatically on each slice and manually checked. From these ROIs, the lesion volume was calculated over all slices (volume of lesion/total brain volume) and expressed as a percentage. Penumbral tissues were estimated by evaluating both T2 and DWI lesion volumes and comparing these to the final imaging time point, as we have previously described [17].
Histopathology and Immunostaining
Animals were perfused with 4% paraformaldehyde on day 7, and brains were removed and embedded in a gelatin matrix using MultiBrain™ Technology (NeuroScience Associates, Knoxville, TN) as previously described [18]. Coronal sections were stained with thionine (Nissl), and immunohistochemical procedures were performed on the adjacent sections. To quantitate infarct volume, histological sections were digitized at nine standardized coronal levels and analyzed (MCID™ Core imaging software, Linton, Cambridge, UK) as previously described [16]. Infarct volume was calculated as the integrated product of cross-sectional area and intersection distance and corrected for brain swelling. The following antibodies were used: glial fibrillary acid protein (GFAP, Santa Cruz, SDS Biosciences, Sweden) to label reactive astrocytes, Cd68/ED-1 (Serotec, Raleigh, NC) for activated microglia/microphages, and neuron-specific nuclear protein (NeuN, Chemicon/Millipore, Billerica, MA). The number of GFAP, ED-1, and NeuN-positive cells were counted (Zeiss Axio Imager 4.6.3) in the cortex and striatum at the level of the central lesion (bregma level −0.3 mm; magnification ×40). Data were expressed as numbers of positive cells per high-power microscopic field. Brain slices were imaged on a Zeiss LSM-510 Meta laser confocal microscope with a ×10 objective (Zeiss Plan-NEOFLUAR 10×/0.3). Fluorophore visualization (excitation/emission capture) was achieved as follows: GFAP, DyLight 488 (488 nm/505–530 nm, green); and ED1, DyLight 594 (594 nm/603–636 nm, red). The image resolution was set to 2.26 μm/pixel and the cubic voxel dimension was 129.5 μm. Computer-generated MosaiX-processed images of Nissl, GFAP, ED-1, and GFAP/ED-1 double staining from saline and DHA rats were generated.
Lipidomic Analysis
Rats were perfused with cold ice saline at 3 days after stroke. For each animal, the brain was removed and blocked into two segments that included the bregma levels +2.7 and −0.3 mm. Next, coronal blocks were divided into right and left hemispheres and cut into two regions (one for the cortex and one for the striatum). Neuroprotectin D1 (NPD1), the DHA-derived stereoselective lipid mediator, and 17-HDHA (a marker of 17H(p)DHA, the short lived-NPD1 precursor) were isolated from the penumbra as previously described [9] using a liquid chromatography-photodiode array ultraviolet detector-LTQ linear ion trap mass spectrometer (LC-UV-MS/MS; Thermo, Waltham, MA) equipped with an LC column (150 mm × 2 mm × 5 μm, LUNA C18, Phenomenex, Torrance, CA).
Statistical Analysis
Data are presented as mean values ± SEM. Repeated-measures analysis of variance (ANOVA) followed by Bonferroni procedures to correct for multiple comparisons were used for intergroup comparisons of neurobehavioral scores over time and infarct areas across coronal levels. Two-tailed Student's t tests were used for two-group comparisons. Differences at p < 0.05 were considered statistically significant.
Rectal and cranial (temporalis muscle) temperatures, arterial blood gases, plasma glucose, and hematocrit showed no significant differences among groups. There were no adverse behavioral side effects observed after DHA administration to rats in the present study.
Series 1: Therapeutic Window Study
Series 2: MRI Study
Series 3: Lipidomic Study
In this study, we have demonstrated that systemic administration of the DHA provides neurobehavioral recovery, reduces brain infarction and brain edema, activates neuroprotectin D1 synthesis in the penumbra, and promotes cell survival when administered up to 5 h after focal cerebral ischemia in rats.
DHA is an essential omega-3-fatty acid and is vital for the proper brain functioning. It is also necessary for the development of the nervous system, including vision. Moreover, omega-3 fatty acids are part of a healthy diet that helps lower the risk of heart disease. DHA belongs to the omega-3 essential fatty acid family. As a consequence, we depend on the dietary supply of DHA or of its precursor, linonenic acid (18:3, n-3). DHA has potent anti-inflammatory effects [5, 13, 19]. Since inflammation is at the root of many chronic diseases, DHA treatment has been widely demonstrated to have beneficial effects in patients with coronary heart disease, asthma, rheumatoid arthritis, osteoporosis, sepsis, cancer, dry eye disease, and age-related macular degeneration [19].
Cerebral ischemia is characterized by a rapid accumulation (within minutes) of free fatty acids, including arachidonic acid (AA; 20:4 n-6) and DHA (22:6, n-3), due to increases in intracellular calcium and activation of phospholipases [20]. This free pool of AA and DHA is then converted via active enzymatic processes as well as free radical-mediated lipid peroxidation into a cascade of activated pro- and anti-inflammatory mediators, the makeup of which ultimately drives the cell toward survival or programmed cell death. Specifically, after hydrolysis, free (unesterified) DHA is converted to form the stereospecific mediator NPD1 in a series of reactions beginning with lipoxygenation by 15-lipoxygenase-1 followed by epoxidation and hydrolysis reactions (Fig. 4) [11]. NPD1 acts against apoptosis, promotes cell survival, inhibits brain ischemia-reperfusion-mediated leukocyte infiltration and pro-inflammatory gene expression, promotes neurogenesis, attenuates edema formation, and reduces stroke volume 48 h after MCAo onset [9, 21, 22]. Recently, we showed that administration of human serum albumin complexed with DHA results in increased NPD1 production in the ipsilateral hemisphere, but not the contralateral hemisphere. These results indicate that NPD1 synthesis requires available DHA as well as harmful noxious stimuli causing cellular damage [22].
Due to the challenges of treating patients in a timely manner, an extension of the therapeutic window is necessary to allow for broader appeal to clinicians treating ischemic stroke victims. We asked if DHA could prolong the therapeutic window in a setting of focal cerebral ischemia. In our previous DHA dose–response study, we showed that a low dose of DHA (3.5–7.0 mg/kg) has the greatest effect on reducing infarct volume when administered 3 h after MCAo onset [15]. We selected a dose in the middle of the effective dose range (5 mg/kg) for our therapeutic window study, which proved to be effective even with a delay of treatment up to 5 h. Treatment with DHA significantly improved the neurological score on days 1, 2, 3, and 7 compared to vehicle rats even when treatment was initiated as late as 5 h after onset of ischemia. The effect of DHA was also demonstrated clearly in the cortical (or penumbral region) of the infarct by a significant 49% reduction of cortical infarct volume when administered at 3 h, by 77% at 4 h, and by 71% at 5 h as compared to vehicle-treated rats. This effect was associated with a reduction in edema (T2 normalization). MRI studies showed that DHA treatment clearly reduced the level of edema and significantly reduced total lesion volumes compared to the saline treatment on days 1, 3, and 7.
Ischemic stroke intervention requires mixed cellular protection of the penumbra. The term neuroprotection is typically used to describe the protection of neurons from the neurotoxic environment that occur during ischemia. However, the complex processes that occur after stroke require the targeting of multiple factors and cells, including glia, vascular, and inflammatory cells. The histologic distribution of molecular markers in the infarcted regions of DHA-treated brains differed from saline-treated brains in that DHA brains showed attenuated cellular death of both astrocytes and neurons and fewer activated microglia, as compared to saline-treated brains within the infracted region. These results indicate that treatment with DHA protects not only the neurons but astrocytes, which are critical for the maintenance and protection of neurons via the secretion of growth factors and other neurotrophic mediators. Furthermore, DHA attenuated the activation of microglia. Microglia are activated by cellular damage and typically initiate an inflammatory response that results in apoptosis and debris removal. This effect demonstrates DHA's anti-inflammatory properties during cellular stress.
The next question we asked is whether DHA rescues the ischemic penumbra. The ischemic penumbra (defined as local cerebral blood flow (LCBF) of 20–40% of control) forms an irregular rim around the ischemic core and tends to be greatest in frontal and occipital cortex [23]. Although reduced LCBF is a major factor responsible for necrotic injury, other factors, including lipid peroxidation, inflammatory responses, and development of brain edema, may also contribute to either the severity or progression of penumbral injury [24]. Stroke patients (44%) may have penumbral tissue even after 18 h [25]. DHA has been shown to be neuroprotective and is the precursor of NPD1, a novel lipid mediator with powerful anti-apoptotic and pro-resolution properties during oxidative stress and cellular damage.
Our lipidomic study demonstrated that DHA treatment activates NPD1 synthesis in the salvageable penumbral region of the infarct, which typically succumbs several days after the initial ischemic insult due to the subsequent widespread inflammatory response elicited by ischemia, rather than the actual ischemic episode. DHA is converted through 15-lipoxygenase-1 into NPD1, a potent mediator that evokes counteracting cell-protective, anti-inflammatory, pro-survival repair signaling, including the induction of anti-apoptotic Bcl-2 proteins and inhibition of pro-apoptotic Bcl-2 proteins. Thus, NPD1 triggers activation of signaling pathway/s that modulate/s pro-apoptotic signals, promoting cell survival as well as inflammatory resolution [26]. Thus DHA/NPD1 is a mechanism for protection in the ischemic brain penumbra, amenable to further translational approaches.
We have shown that DHA administration provides neurobehavioral recovery, reduces brain infarction and brain edema, activates neuroprotectin D1 synthesis in the penumbra, and promotes cell survival when administered up to 5 h after focal cerebral ischemia in rats.
We thank Pedro Hayes, Dr. Elena Titova, and Eric Knott for technical assistance; Dr. Thompson for statistical analysis; and Neuroscience Associates, Inc. for histology service.
Sources of Funding
This investigation was supported by NIH, NINDS Grant R01 NS046741 (NGB) and NIH, NCCAM Grant RC2 AT005909 (NGB). Tiffany N. Eady is a recipient of the Ruth L. Kirschstein National Research Service Awards for Individual Predoctoral MD/PhD and Other Dual Doctoral Degree Fellows (NIH, NIA Grant F30 AG032841).
The authors declare no conflicts of interest.
Open Access
This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.


text:
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Lydbog (Bånd), [PD: 15/08/2005], [PU: HarperCollins Publishers], Seiten: 0, [ED: New title], This book is a tribute to the late Bobby Moore, captain of England's World Cup winning side of 1966, one of the greatest footballers of his generation, and a man who personified Britain in the swinging sixties. This is his powerful and moving human-interest life story, as told by his wife Tina, including his battle against cancer. 'But Bobby had been in that dark place before Lance Armstrong was even born. In many ways it was even more devastating! In those days cancer was something you just didn't mention, a taboo word, a fearful prospect. All I could think was, he's only 23 and he's been handed his death warrant.' Bobby Moore's death in 1993, at the age of 51, had a profound impact on the people of this country. As the only English football captain ever to raise the World Cup, he was not just a football icon but was also a national one. Yet Bobby was an intensely reserved, almost mysterious personality. Only one person was his true friend and confidante - his boyhood sweat heart, Tina, whom he met at 17 and married soon after. With her, he went through all the triumphs and crises of his professional career - the life-threatening illness that struck him at 23, his clashes with West Ham (and later England) manager Ron Greenwood, his emergence as a footballer of international renown, the almost unheard of media intrusion and the kidnap threats on their children, that amazing 1966 World Cup Final day, the drama of Bogota when he was accused of theft, and his depression as he struggled to adapt to the end of his playing career. Tina Moore's story of her life with Bobby, the break-up of their marriage and what happened after wards, is inspirational, candid and told with revelations and authentic insight into what made Bobby tick. Alongside previously unseen material that sheds new light on his character and anecdotes about players, wives and managers told from a female perspective, it is a moving tribute to a national icon by the person who knew him better than anyone.
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Bobby Moore: By the Person Who Knew Him Best
Details of the book - Bobby Moore: By the Person Who Knew Him Best
Publishing year: 2005
Publisher: HarperCollins Audio
Book in our database since 17.10.2007 22:38:33
Book found last time on 06.08.2016 03:45:52
ISBN - alternate spelling:
0-00-721366-2, 978-0-00-721366-5
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text:
Base Backpackers (Brisbane Embassy) VIP
A peaceful haven in the heart of the city, Base Embassy Brisbane has state of-the-art facilities including spotlessly clean, air-conditioned and spacious rooms. The environment is calm and offers an escape from the business of the surrounding city. Linked to Base Central, Base Embassy guests can enjoy access to both facilities.
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text:
One of Apple's iPhone patents -- the one that a jury used to decide that Samsung owed Apple hundreds of millions of dollars in damages -- was just ruled invalid by the U.S. Patent and Trademark Office.
The patent in question, D618677, covers the design of the iPhone 3G and was filed in November 2008, but Apple relied on two patents filed in January 2007 to give that 2008 patent an earlier protection date. It's a common practice, but the earlier patents have to sufficiently describe the later one in order to extend the protection date. The U.S. patent office decided that those two original patents didn't describe the design patented in late 2008 sufficiently enough, and that perhaps that patent should have never been issued to begin with, according to FOSS Patents.
In the nearly two years between the two patent filing dates, a host of other smartphone makers produced phones that looked similar to the iPhone, including Samsung. Those devices stand as "prior art" now, which means that the patent covers design traits that were already common by the time it was filed.
The story behind the story: Samsung is still fighting the $548 million damages bill it owes Apple, money that was awarded largely due to this now invalid design patent. A date for a new trial, the third in this lengthy legal battle, has yet to be set to determine the final amount Samsung owes, but it's likely that Samsung will point to the patent office's ruling as evidence that it owes Apple nothing.
This story, "Apple vs. Samsung rages on as core iPhone patent is ruled invalid" was originally published by Macworld.


text:
Would you like to save as your currency permanently or for this visit only?
The staff were very helpful. We speak very little German but they were patient with us and explained things as best they could — particularly the restaurant staff — which helped us to enjoy our stay. A kettle/complimentary tea bags/milk in our room would have made it perfect.
personal attention
Location - location - location. 50 metre walk from old town - very nice balcony - friendly staff. Hotel is not aceesible by car. Must park in lot approx 200m and carry suitcases to hotel. Not rec for arriving by car. Warning - do not drive car to hotel to drop off as getting out is difficult at best.
Wonderful hotel in beautiful Luneburg! This is really a great place to stay when visiting Luneburg. Staff is very friendly and helpful, beautiful large room, excellent location of the hotel in the middle of the old town, spectacular view on the city, really nice terrace for dinner and breakfast, excellent breakfast, very convenient garage facilities. One of the best places where we staid! And we travel a lot... Really a great place I would recommend for city travelling, romance/honeymoon, etc. I will go back! Really nothing!
Hotel is very convenient to the 'old town'. Beautiful location on the Ilmenau River and little harbor. Room was very large and nicely furnished. All buildings of the complex are conveniently sited to each other. Very desirable place to stay. Pillows were not up to the standards of our other hotel accommodations.
The hotel was fantastic, in a beautiful location within the town. Thoroughly reccommend it. Food in Mama Rosa's was excellent.
No air conditioning made room uncomfortably hot.
very good location,romantic riverside room is very comfortable. expensive a little,considering room equipment.
rooms clean, facilities excellent no way to get your luggage to th room easily!!!
The restaurant has to poor food !
We booked a luxury room, and booking.com confirmed our booking,but this type of room was not availeble when we arrived. Instead we got a suite. When we left the next day we were charged for the suite, € 30,00 more than the confirmed booking.
Spacious, comfortable room in a beautiful building, gorgeous view, cocktails on terrace by water Breakfast not included in the fairly hefty price of a room
This was a wonderful hotel in the heart of the Old City. The staff was very friendly and the food was excellent. We would definitely stay here again.
The location and the walks around the hotel. Breakfst at 15 euros per person is very expensive
Rooms and Spa No
Visit CeBit-fare in Hannover
Located a few blocks from the Rheine River. Rooms were clean and had big windows. WIFI is an additional fee of 13 Euros for 24 hours.
The sauna - turkish bath facilities; the free membership to the excellent sports centre next door. The lovely walk around the golf-course. The excellent range of evening cocktails!! The breakfast, although good, is expensive at 14 euros per person. It is hard to imagine anyone eating that amount of egg, bacon and sausage etc!!
Welcoming and smiling staff - at any time of the day or night! Excellent spa facilities. Outstanding fitness centre next door that was included in the price.
Spa and close to golf.
Great location and wonderful design. There is no information about the hotel or town in English, only in German.
the room n/a
There's no substitute for a new building, and smart design. This hotel is only two years old. Simple, clean and neat, very attractive. The only reason you'll avoid this hotel is if you insist on 5 star appointments.
We were given rooms on the street side with noisy roadworks. Since the hotel was not fully booked, I would have expected a quiter room, even if this would mean an upgrade from them. Otherwise, very nice hotel conveniently located.
The staff was excellent; the hotel is brand new, with sleek design; bathroom was small but perfectly adequate with good shower; excellent restaurant for dinner and delicious breakfast buffet spread; quiet neighborhood. We had not brought a laptop so were disappointed when we discovered they did not offer a computer for guests' use in the lobby area. There was wireless in the rooms if you had your own computer.
+/- Expensive but great Breakfast, 15€ p.P.
Location, parking possibility in front of the hotel, quick response to extra wishes, more or less breakfast and spa the carpet was not clean, the lady for massage was not awailable on weakend and there was no alternative
Nice area,close to downtown. No
I was staying at a room for wheelchairs and it worked very well. The mirror in the bathroom was mounted to high was a wheelchair user.
New and clean hotel. Very reasonable prices and "does exactly what it says on the tin". Buchholz is a rather unremarkable town just south of Hamburg but excellent if you are stopping of on the A1 or need reasonable access to Hamburg with a car but don't want to pay city centre prices. Parking charge only required if you leave after 8am Parking charge if you leave your car there throughout the daytime.
Very good hotel nearby Hamburg. Clean and nice room. Hotel has very good restaurant. Breakfast was excellent.
the rooms are small, not nicely furnished, breakfast 14 € for nothing
The room is nice and clean. Surrounding area is quiet and nice. When checking in, I asked reception to remind me if breakfast was included or not, as I forgot. They said it wasn't, it had to be paid as extra. I checked later in my booking and it said it was included.
Friendly staff, decent rooms, parking under the hotel - all good.
The Achat hotel is a reasonably priced hotel located nicely in the near to the Lüneburger Heide. Rooms are decent, Breakfast is quite good.
We enjoyed our stay and found the room very confortable.
The room was fine. Evening meal was a good example of authentic rustic German country food. Many of the ingredients were home made. A little like an old peoples home.
Very nice hotel with friendly staff.
Location. Internet access. Personnel is not very friendly. Room for 4 people was too small and 2 beds were located in tiny space. Restaurant quality was poor although in the web was recommendable. Quality-price of both hotel and restaurant is bad.
All was perfect. if I travel in Munich area in ther future i will stay again in the hotel
Service and staff are perfect. Rooms are super. Nice environment. Everything was excellent !
We like the location and the atmosphere at the hotel and the city.
The village and hotel is nice. The personnel are very friendly. The breakfast is very fine. I would like to visit the hotel again.
A small, pleasant hotel in a leafy neighborhood. Close to plenty restaurants and good public transportation.
Wonderful location and couldn't have been happier. We were made to feel so welcome and would love to stay again soon!!! Thank you for such a great recommedation!
We used this hotel as a stop over on a road trip from Germany to Sweden. The reason we picked it was the ease of access from the Autobahn. As always in Germany, the breakfast was great. I suppose we might stay there again if we were doing the same trip, but it wasn't really our kind of place. It was a bit overpriced. I would expect to pay that amount for a hotel of the same standard in a city centre, but not one located out in the country.
Nice rooms Breakfast shoud start 6.30 instead of 7.00
Location. Free entrance to solebad No air-conditioning. Bikes are no longer for hire
Ability to use for two hours SaLue included in price. Excellent breakfast. Spacious room. Complicated parking - perhaps this is temporary due to building works. Design of furniture / arrangement of furniture in room suggests corporate meeting room / environment. Prefer proper shower rather than standing in bathtub.
Easy parking
Good location,a little to remote for our gps :) but we had a nice stay. Luneburg is interesting, with a nice old architecture.
Kindness off the staff, fruit in the room.
the room is good.The breakfast was very nice and delicious
The room The staff
The restaurant was wonderful and convenient. The room was very nice as were the amenities.
The situation of the hotel is great, just outside Luneburg but right in the heart of the country (great for walks). The restaurant has decking overlooking the millpond and it was a fantastic spot to sit outside for dinner and breakfast. It is obviously popular with locals because they were busy every night we were there (early in the week). Staff (that we met) were friendly. Our room was dark and situated at the back of the building with no view which was really disappointing. There was no one on reception, we had to get the key from the restaurant so we didn't feel it was very welcoming (unlike everywhere else we've stayed) and a fax wasn't passed on. Would suggest you request a room at the front if you can.
We stayed in the new building next to the car park. The room was modern and fair with a wiev to a field where deer showed up a couple of times during the few ours we stayed there. The restaurant was kept in a very nice old style, and so were the other buildings. The near surroundings with the pond and ducks where very charming.
Charming, not to far from autobahn for an overnight stop. Very good restaurant for evening meal and excellent breakfast. Initial reception not easy as we had to go to the restaurant, and the only one in situ was a waitress. [15 minute delay!]
The beautiful location and facilities No lift, which was not a problem for me but would have been this time last year.
Although visited in late Octoer rain, the place was very inviting and nice. Room was clean and spacious. Food in the restaurant was excellent. All in all, this place is recommended.
Mycket fina hotellrum, trevlig personal och trevlig restaurant. No
Staff! Very friendly and warm. Very good breafast. :-)). We stayed at this hotel in the early phase of our drive through Europe, and also on our way back home. On our way back home we arrived very late but had an appointment to pick up our key for room 22. Excellente service! Mette og Ivar No. Only positive words to say about our stay here.
The staff were very friendly, good breakfast, OK price, easy access to Motorway. Closing already at 22,00.
Typical German Gasthof. Friendly and varm. Good kitchen.
The location is pleasant and quiet, the hotel has atmosphere, and many walks can be undertaken from the hotel (within a few metres there is a heather landscape). The indoor swimming pool is unusually large and warm. The hotel is rather dominated by horse activity, and this can also be interesting for outsiders to watch. We agree with other reviewers about slowness of service. This was our experience both on the terrace in the afternoon and in the restaurant in the evening (despite only one or two tables being occupied). We also on more than one occasion had to get up and remind staff of our presence, and to get something else to eat or drink.
Beautiful and quiet surroundings. Very nice staff. Large rooms. Good food. Pet friendly. Nice swimming pool. It was hot when we stayed there. An air conditioning would be nice.
We liked the atmosphere which is why we returned there for another night. Friendly staff. Lovely hotel rained all the time we there so didn't get chance to explore the area.
Very large family room, excellent service
Our 3-person room was big, the beds were firm and quite comfortable, the buffet-breakfast was tasty and freshly made.
A good breakfast buffet. 45 minutes to wait for a sallad is too long, I think.
Very good Hotel. 3 to 4 class service, lot of parking place, comfortable room, free welcome drinks, good restaurant, "gemutliche" atmosphere. Romantic touch. Breakfast included and that all for only 75 euro's for a double room. The town is little but with a very nice old centre.
This hotel is an older facility, but it was exceptionally clean. Our dinner in the dining room and the breakfast buffet were both excellent.
Ruter's Hotel provided excellent facilities and was set in a picturesque and very pretty village. As a personal preference, the beds were too soft.
the welcome and the family touch. traffic noise at night was intrusive when the weather was hot and the windows had to be opened
Excelent value for the money. Free Wireless Internet. Breakfast much better than expected.
The location,room size,the restaurent terrace view lack of staaf
Nice and big rooms, big and comfortable beds, friendly staff.


text:
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text:
And the wait is finally over! The Tamil version of ace cinematographer Santosh Sivan's much awaited Urumi is getting ready for release. Music composed by Deepak Dev is all set to be released in Chennai on November 15, 2011. Actors Vijay, Arya, directors Mani Ratnam and A.R. Murugadoss are likely to release the audio CD. This magnum opuswith Prithviraj, Genelia, Vidya Balan, Tabu and Prabhu Deva in the lead roles is expected to grace theatres by November end!
The Malayalam and Telugu versions of the film have already seen the light of day. The film, which has been well appreciated by critics and audience alike, was recently screened at the prestigious Busan Film Festival and has been selected as the inaugural film for the prestigious International Film Festival of India this year.
SOURCE: http://bit.ly/tpAJb5


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Outstanding Nikon Product!
The Nikon D300s can be considered as either an entry-level pro DSLR or a top-of-the-line prosumer camera. Either way, this model is a workhorse with a construct and features well worth the significant investment. If you're looking for a point-and-shoot then choose something less expensive, but if you want reliability, flexibility and adaptability, then definitely choose the D300s. A piece of advice--if you buy this camera by all means don't buy a cheap lens. Buy the best glass you can afford, otherwise you'll fail to get the quality this camera is built to produce.
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Hey, guys, Crazy4Seddie here.
'Just thought I should tell you that my life's getting too busy to keep up all my comments and edits on this wiki, so I've decided to leave for now.
Also, I sincerely apologize if I have ever said anything hurtful to anyone in the past. I know I can be a bit defensive sometimes, but...LOL, that's just the way I am. xP
Anyways, I'll probably return for a while around Halloween, and a few new iCarly episodes should've hopfully aired by then. :)


text:
Eduardo Mendez was a veteran Starfleet officer and captain of the USS Columbia. He was killed in 2370 after succumbing to wounds sustained during an attack on the Columbia. (The Star Eagle Adventures)
Mendez was a strict but fair captain who inspired great confidence and respect among his crew. Both Amaya Donners and Michael Owens served under his command and considered him an imperturbable mentor.
Mendez had at least one son, Nelson Mendez, who served with him as an officer on the Columbia but was killed when the ship was destoryed in 2371. (The Star Eagle Adventures: Paternal Instincts)


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text:
It's time to go. I walk out the door and head
toward my car. But right before I get there I slip on the ice
and fall down. Hard.
I swear a few times and then head in the house. I lay flat
on my back and breathe.
I know why I fell. There is a part of myself that is
protesting my decision.
I am heading to Detroit to surprise my friend Lara for her
40th birthday. I am only staying for the night,
but it's still 10 hours of driving and a night away from home.
I have Christmas cards to write, presents to wrap, work to do,
and of course, three children and a husband that will have to do
without me.
But I want to go. This is a decision I made two weeks ago
with no hesitation. It came to me in the shower (this is when
most of my ideas come, so I tend to take long showers), and I
emailed Lara's husband immediately to make the plan.
It was my heart speaking, but my heart is not the only part of
me that has a voice. I have another voice that is practical,
planned, and controlled.
This is the part of me that wrote college papers a week before
they were due, and the part that enjoys checking tasks off my to-do
list. It's the part that meets work deadlines and makes sure
that my girls get to school on time.
It's an important part of who I am - it's dependable and
responsible and I honor what it provides.
But it can't always be in charge. Constantly living from
this place is too stifling, too demanding, and basically not fun,
especially because it's afraid to fail. It serves me, but
when it has too much power I get stuck.
My heart decisions are free and exciting, fun and
inspiring. Like when I decided to change my major to
education my junior year in college, and when I moved to Chicago 17
years ago with no job and no plan.
Or the time that Lara and I decided to fly to Mardi Gras for
just 24 hours, or when I decided to become a yoga teacher.
These were heart decisions - they felt right, but they didn't make
sense logically.
So one voice reminds me to keep my feet on the ground and the
other voice reminds me to let my spirit to soar. Much of the
time they are wonderful partners, but like most partners, they tend
to have power struggles.
I take one more deep breath, stand up, and then look in the
mirror. I say out loud to my practical self - It's a good
choice to go to Detroit today, so let's go.
So I get in my car, turn on my new CD and drive off.
And I don't even need my GPS - I already know I'm headed in the
right direction.
Cathy Adams is a certified parenting coach, yoga instructor and mother to three girls.
See more of Cathy's stories here.
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SOLD Nikon F100 w/ MB15, $400 - SOLD
marcus2006 Registered since 07th Sep 2006
Thu 28-May-09 05:17 PM | edited Sun 04-Oct-09 09:39 AM by marcus2006
For sale is a Nikon F100 with MB-15 grip in excellent condition, near new. Only about 50 rolls of film through the camera. Everything functions as it should. Asking $400. Local pickup in Toronto welcome. Payment by verified PayPal. Will ship using ExpressPost - buyer pays cost of shipping.
Visit my Nikonians gallery.
#1. "RE: SOLD Nikon F100 w/ MB15, $400" | In response to Reply # 0marcus2006 Registered since 07th Sep 2006Thu 28-May-09 08:36 PM
This item is now sold. How do I delete the ad?
Visit my Nikonians gallery.


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Time to add #FreeChiefKeef to the lexicon of hip hop hashtags. The young Chicago rapper was jailed yesterday for violating his probation, and—bizarrely enough—the music taste-makers at Pitchfork might've helped put him behind bars. Keef (birth name: Keith Cozart) was sent to jail after a judge ruled that he violated the terms of his probation by waving a gun around in a promotional video for the music website Pitchfork. Cozart—the 17-year-old leader of a very real and often violent new rap genre that recently emerged from Chicago called drill—is now in custody at a Cook County juvenile holding facility, according to The Chicago Tribune's Jeremy Gorner. He'll be sentenced tomorrow.
RELATED: How Pitchfork Might Have Sent an Artist to Jail
This isn't the first time Keef has had trouble abiding by the terms of the 18-month probation he received for pointing a gun at a Chicago cop back in 2011. A few weeks ago he was brought before a judge for allegedly moving out of the city to a big house in the suburbs of Northbrook. But the court ruled that there was no credible evidence he'd established a new residency (forbidden under the terms of his probation), so he was allowed to walk free. Playing with guns (with Pitchfork egging him on) apparently crossed the line, though. Listen to the second single off Chief Keef's well received debut album Finally Rich below.
RELATED: Major Private Equity Firm Is Getting Out of the Gun Business


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08 Aug 066 Review of ATO's Management of Tax Litigation report releasedIn a press release issued on 7 August 2006, the Minister for Revenue and the Assistant Treasurer, Peter Dutton, announced the release of the Inspector-General of Taxation's (IGOT's) report of his Review of ATO management of Part IVC litigation.
The report looked at the ATO's administration of tax litigation arising from the appeal procedures of Part IVC of the Taxation Administration Act 1953. Included within the report is an evaluation of the test case litigation program.
The IGOT has made recommendations to the ATO that are designed to improve both the operations and perceptions of administration of the tax litigation programme. The IGOT recommended that the ATO:
- develop a published policy or guidelines on tax litigation;
- give a single area of the ATO overall responsibility and authority for the management of all aspects of litigated cases;
- introduce risk management techniques to its management of litigation issues; and
- introduce a standard communication product to communicate the application of finished court and tribunal decisions.
The Commissioner's response to the IGOT's recommendations is included in the report.
The IGOT also made recommendations to the Government for improving the test case funding programme and the funding of taxpayers' costs where the ATO appeals against a court or tribunal decision. In response, the Minister said that the Government will be establishing a new review body, to be headed by the Treasury, to review the submissions of unsuccessful applicants for test case funding. The Government will develop guidelines about Commonwealth funding for taxpayers' reasonable legal costs where the Commissioner appeals against an adverse decision.
The Government's response to the IGOT's recommendations is attached to the Minister's press release.
For a copy of the Minister's press release, No 2006/061, 7 August 2006, go here
For a copy of the IGOT's report, go here


text: To get from Ventimiglia to Viareggio by train you can catch one of the 10 trains that everyday travel between these two cities. The first train to Viareggio leaves from Ventimiglia at 04:40 and the last train departs at 16:38. If you choose a local train the trip lasts on average 04:07 hours. For your trip from Ventimiglia to Viareggio by train you can choose to leave from one of Ventimiglia main stations: Ventimiglia Prices for next month range from € 16 to € 16. The most economic train is Intercity () that departs at 06:32 and arrives in Viareggio at 10:39 at € 16. On Wanderio you can compare all schedules, fares and railway companies to Viareggio and book the best itinerary starting from Ventimiglia.


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Pet Sitter in Scottsdale
Hello! I am 17 years old and I have grown up with animals my whole life! I have loved animals since I was young and love the bond I share with them. I currently own a dog named Lou and he is my best friend! I have owned other dogs and cats in the past and I love dto care for them! Making sure an animal is happy and healthy is number one to me and I enjoy playing with them and being active. Thankyou!
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Currency trading and the euro. The price of euro indicates consolidation before the decision of the Fed on monetary policy, which will be published today at 19:00 GMT. It should be noted that the probability of changes in the parameters of monetary policy today is minimal, but the Fed may hint at future plans for raising interest rates. It is noteworthy that poor statistics in the United States reduces the possibility of raising interest rates in March, which has a positive impact on the price of the euro. Today, the dynamics of trading will also affect data on the index of consumer confidence in Germany from the Ifo (07:00 GMT) and new home sales in the US (15:00 GMT). We maintain a medium-term negative outlook for the euro.
Currency trading and the British pound. The price of the British pound showed growth yesterday after the statement of the Bank of England, in which he said about the lack of conditions for the increase of interest rates in the UK. In addition, it was noted that about 70% of investors believe that the decline in global equity markets, low gasoline prices and slowing growth in emerging markets will not affect the British economy. Tomorrow will be published preliminary data on GDP growth in the UK in Q4 and accelerated growth can lead to a continuation of the upward trend of the British currency. Our medium-term outlook remains negative, but the current correction may continue in the near future.
Currency trading and the Japanese yen. The price of the Japanese yen strengthened slightly against the US dollar. Investors are waiting for the Fed's decision on interest rates today (19:00 GMT). At the same time, strong price movement is expected on Friday, following a statement by the Bank of Japan on monetary policy whose settings can be changed in the direction of easing to counter the effects of a stronger yen and a decline in the equity markets of Japan. Tomorrow the course of trading may also affect data on retail sales in the country. Our medium-term negative outlook for the yen remains unchanged.
Currency trading and the Australian dollar. The price of the Australian dollar showed growth against the background of the weakening US dollar and rising commodity prices, which traditionally has a strong impact on the dynamics of the national currency of the country. It is worth noting that today was published statistics on inflation in the country in the 4th quarter. Thus, the figure was 0.4%, which is 0.1% better than the forecast, but 0.1% less than the previous period. Slowing inflation stimulates the Reserve Bank of Australia to lower interest rates, but we do not expect this event soon. Our medium-term outlook remains negative, despite the possible continuation of growth in the near future.
Currency trading and the New Zealand dollar. Price of the New Zealand dollar shows a positive trend against the background of the Australian dollar. Investors did not rush to accumulate positions before the announcement of the Reserve Bank of New Zealand monetary policy (20:00 GMT). According to our forecasts, the New Zealand central bank will leave interest rates at the same level, but it may hint at their decline after the next meeting. We maintain a medium-term negative outlook, and expect increased volatility today and tomorrow.


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RJW Photography Photographer
Lauryn_RaeModel Female Minneapolis, Minnesota, US
Mayhem # 3052731
About MeI have been in a few fashion shows the last year, and have also done a couple photo shoots once in a while! My goal and dream is to get more into the modeling career and go further and further with it and see where it takes me!
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Looks like Rimal, JBR. Awesome place to live!
Really a fantastic perspective!!! A futuristic view, indeed. Very well achieved.
you dnt care to the camera if it fall down
wANT TO BE THERE EXCELENT PHOTO!
Great photo!
like a boss
whoa, tall, did you get vertigo? i'm getting dizzy just looking at it.
excellent capture.
Awesome capture!
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Wow! This is such a nice picture! I looove heights! ^^
great view
beautiful work
beautiful work
I've vertigo
I've vertigo
woa! awesome! and vertigoish
Mighty pimp shot!
Cool view up there!
this is quite an amazing picture!
Whoa! Wow! Now that is something to look at!
Super view and angle!
that is cool
Awesome pic!!!


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The Best Skin of Your Life Starts Here
Blackheads are caused by an accumulation of dead skin cells and excess sebum which get trapped in your pores. Once the clogged pore is exposed to air, it oxidises, forming a blackhead.
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Mesh within a mesh
Hi ANSYS Gurus,
I am planning to use ICEM CFD to mesh a cold plate with embedded fluid serpentine channels. First, the channels will be meshed intricately, and then the metal body. The outer metal body will be meshed in a simple manner using a bounding 3d block; which will also include the channel volume. Will the internal detailed mesh overwrite the outer coarse mesh in the channel sections? If so, there will be no need to mesh both bodies intricately.
|All times are GMT -4. The time now is 23:50.


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Live Classroom Sessions
Live class sessions form the core of Scholars Online education. Teacher-led discussions of the material challenge the student to grapple with ideas and their application to real-life situations.
Class sessions meet in real time on a regularly scheduled basis, usually once or twice a week for an hour to ninety minutes. Some classes may meet more often or have extra sessions for course or standardized test preparation. Because we recognize that education is a community effort, all students are expected to attend all scheduled class sessions, to notify the teacher (in advance if possible) when a session will be missed because of illness or other unavoidable reasons, and to make up any work missed during absences. Individual instructors may grant exceptions on a case-by-case basis.
Our classes are not lectures. Students can easily and more efficiently read teacher-written lecture materials on course websites. The classes are lively, interactive discussions of the material—a chance for students to ask for clarification of textbook and website materials, get help with homework exercises, gain experience explaining what they have learned to their peers, and interact at a social level with each other and their teachers. Participation in discussion forces students to learn to "think on their feet" and see the materials from several different perspectives. Teachers may enhance the classroom experience by leading students on web tours of related or useful sites, using pictures, diagrams, and even interactive models to help students visualize and engage with the materials presented in the course.
We currently support two classroom technologies: a custom-written text chat program (which we'll simple call chat hereafter), and the WiZiQ audio and whiteboard system. We are committed to finding and using appropriate technologies for course material, rather than chasing every new feature for its own sake.
Chat is a text-based method of communication. Every member of the chat session can see and reflect on what other members are typing into the main chat window. Our browser-based chat software was specifically designed by Dr. Bruce McMenomy to work with the Scholars Online environment and procedures and provide a reliable, low-cost, accessible method of class participation for all students regardless of platform operating system.
We continue to use text chat as our primary mode of class interaction for most but not all classes, at least at present. This does not prevent teachers from using sound files, podcasts, video clips, or other such materials to supplement the class experience. They often embed web media directly in the chat or have students start a second browser window to view the material in real time. Over the last year, our math teachers have pioneered for us the use of the WiZiQ system, allowing them whiteboard and audio capability, and they have been generally pleased with the results. We remain open to new developments when they are stable enough to be reliable and useful.
We've given this a lot of thought. Here are our reasons, some of which are technical, but others of which have more to do with the pedagogical underpinnings of the process itself. The latter issues are really more important to us, since though technology is constantly evolving, in most respects human learning remains a constant.
We also hasten to recognize that this is something you need to figure out with your own students, and we are aware that the medium has to adapt to the material being offered. We are seriously looking into audio software for possible offerings in modern spoken languages as early as next year.
Here as almost everywhere else, one size really does not fit all: there are students for whom this extremely verbal (but non-spoken) mode of communication is liberating and energizing, and those for whom it really is not the right medium. We'd much prefer for you to go somewhere else if that's going to produce the best pedagogical outcome for your students. Watch your students; think about how they learn; pray about it, and make the best choice you can for them.
Audio or video conferencing is not yet so broadly available as to enable all of our prospective students to use it. Despite continuing progress in the field, it is clear from discussions with our students and parents that applying this everywhere would be more of a hindrance than a help. When a text chat is broken up by router problems on the Internet, and the pieces come in somewhat fitfully, the whole meaning of the discussion is retained and presented in order. In an audio chat, this is far less likely to be the case. Some require specific computer platforms; virtually all require high-speed connections (DSL or better) to support streaming sound or video. For some subjects (math, in particular) we have determined that the pedagogical reasons justify the concomitant narrowing of our prospective student base; for others (like literature, history, and science) we have concluded that at present the text chat medium is the better solution.
In the hands of an experienced user, the text chat allows a number of options to enhance the look and feel of text presentation. Teachers can use colors, various fonts and text sizes, and even graphical items to enrich the student experience.
In composing written text, one is engaged constantly in writing practice. This may seem trivial in any given case, but the cumulative effect is considerable. We try to insist on proper usage in class to reinforce this. The constant return to the written word as a baseline of our discourse makes it less strange and strained for the student. We believe that the primacy of the written word is fundamental to classical education, and we strive to preserve that where possible.
In written communication, there is slightly less tendency to "shoot from the hip". The amount of time it takes to write a line or two, consider it, and hit "Enter" affords more opportunity for reflection. Studies in a number of contexts have shown that this can have a positive effect on a student's experience.
One can continuously see the shape of the discussion as it unfolds. Both the student and the teacher can verify that what's currently being discussed really has to do with what has been said before. Nobody ever has to ask, "Can you repeat the question?" It's still right there, a line or two above. Similarly, there's no issue of debating what was said: "But you said..." — "No, I didn't." When communication problems arise (as they will in any form of communication) we can instead attend to what was meant and how to clarify the meaning, rather than quibbling over irretrievable facts lost to scrutiny.
Some will be surprised to find that speed of delivery is also a significant issue leading to our choice of text chat for most classes. The reality, however counter-intuitive it may be, is this: though any one given student almost certainly cannot type and enter new material more quickly than he or she could speak it, in groups the dynamics of this are interestingly altered.
If six students simultaneously enter answers to the same question, all those answers are still discrete and comprehensible. The same cannot be true of audio chat. The WiZiQ allows the teacher to monitor who is able to speak at any given time, to avoid such collisions, but in a large and lively discussion of a more abstract subject like literature, a somewhat freer approach can encourage more participation, and we like to see that.
Our text software is fully Unicode compliant, so it is possible to enter text in languages other than English that require different fonts. Mr. Wynn Rust has graciously supplied us with a utility that allows students to enter Greek text easily from the keyboard without special software of their own. Our classes in Old Norse and Old English have been able to use the special characters required there. We anticipate extending these features in the future.
In an attempt to increase the responsiveness in class presentations, several of our teachers have been using voice-to-text dictation software (especially Dictate from MacSpeech). Only in the last year or so has this technology become stable enough to be useful, but we have been monitoring it for several years, waiting for it to become sufficiently robust for our purposes. This allows more rapid and nuanced responses to be composed quickly in real time, but the result comes across as text and can be preserved as such. (There is nothing aside from the cost of a system to prevent students from using such software as well.)
Though few typists can actually type things more quickly than they could be spoken, it's possible for a teacher prepared with materials and questions for a discussion to insert material into a text channel (and for a student to read and assimilate it) more quickly than would normally be the case even in real-time audio or video chat. The net result is that (contrary to many expectations) more material can actually be conveyed in the same amount of time.
We are dedicated to preserving and documenting what we do, for students and parents to review, and to provide accountability for everyone concerned. After class ends, the content of the chat appears as a log. Similarly, we chose WiZiQ over a number of other competing platforms because it preserves a log of class sessions as well—though these are not preserved for more than a year.
A text transcript of a discussion is something permanent. Some of our teachers still occasionally look back at class sessions from five or more years ago, adapting questions that arose there to the use of current classes. This allows the latest students to benefit from the experience and the ideas of earlier students.
To give you a better idea of the dynamics and content of a real chat session, example chats from our varied course offerings are available in our Sample Chats page. These are actual logs from 2008-2010 chat sessions. The only changes we've made are to student names to protect student privacy.
Orientation sessions during the summer and early fall familarize students and parents with our chat features as well as chat etiquette. Students in our math classes and any others that may require further features will get separate information on how to join and use the software from their teachers.
Scholars Online is currently engaged in accreditation evaluation by MSA-CESS for the 2017-2018 academic year. Courses taken from Fall 2009 - Spring 2017 were fully accredited by AdvancED and NWAC. For more information on accreditation, see our Scholars Online Accreditation page.