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But what does that mean to you? Results.
GERSTEN LAW provides help to those that need effective, results driven, representation. Contact Gersten Law if that's what you need. GERSTEN LAW offers legal services in foreclosure defense, fighting debt collectors, probate/trust litigation, homeowner/HOA disputes, as well as real estate litigation. Look at our drop down menu under "Services" for the service that interests you.


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Shelvey sets sights on United
Liverpool midfielder Jonjo Shelvey hopes to have done enough to earn a place on the bench against Manchester United.
Last Updated: 08/02/12 10:27am
Liverpool midfielder Jonjo Shelvey hopes to have done enough to earn a place on the bench against Manchester United.
The teenager on Tuesday scored and delivered an impressive overall performance for his club's reserve team in a 4-0 win over Norwich.
Liverpool first-team manager Kenny Dalglish was among those watching from the sidelines and Shelvey has his fingers crossed about leaving a good impression on his boss.
The Reds on Saturday lunchtime visit fierce rivals United and the 19-year-old is keen for another taste of Old Trafford having last season played there in the FA Cup.
"Games don't come much bigger," said Shelvey. "I came on last year there in the FA Cup. It was a great atmosphere to play in.
"Hopefully I can be on the bench on Saturday, but we'll have to wait and see. It will be a great atmosphere and we'll have a great set of fans (travelling) there."
Shelvey also has his eyes set on the FA Cup tie against Brighton on 19th February and the Carling Cup final against Cardiff at the end of the month.
"I want to try and play in the FA Cup and hopefully be a part of the (Carling Cup) final," he said.
"That would be lovely and something I could tell my grandkids about when I have them in the future!
"I just want to keep pushing on in training every day and try to force my hand. Hopefully I can get a few starts and come off the bench."

subset: commoncrawl


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Approximately 1 million people in the United States and over 30 million worldwide are living with human immunodeficiency virus type 1 (HIV-1). While mortality from untreated infection approaches 100%, survival improves markedly with use of contemporary antiretroviral therapies (ART). In the United States, 25 drugs are approved for treating HIV-1, and increasing numbers are available in resource-limited countries. Safe and effective ART is a cornerstone in the global struggle against the acquired immunodeficiency syndrome. Variable responses to ART are due at least in part to human genetic variants that affect drug metabolism, drug disposition, and off-site drug targets. Defining effects of human genetic variants on HIV treatment toxicity, efficacy, and pharmacokinetics has far-reaching implications. In 2010, the National Institute of Allergy and Infectious Diseases sponsored a workshop entitled, Pharmacogenomics – A Path Towards Personalized HIV Care. This article summarizes workshop objectives, presentations, discussions, and recommendations derived from this meeting.
Access to antiretroviral therapy (ART) is a cornerstone in the fight against AIDS.1 Interindividual variability in ART pharmacokinetics, efficacy, and toxicity may be affected by genetic variants relevant to drug metabolism, disposition, and off-site targets.2 In June 2010, the National Institute of Allergy and Infectious Diseases (NIAID) sponsored a workshop entitled, Pharmacogenomics – A Path Towards Personalized HIV Care. The impetus was the conviction that knowledge of associations between human genetics and HIV treatment responses can benefit individuals and populations worldwide. This document summarizes the workshop and resultant recommendations.
The workshop assembled individuals with complementary expertise to exchange ideas relevant to HIV pharmacogenomics and to develop recommendations for advancing the field. The first day included presentations by invited speakers, with intervening panel discussions. Participants were then assigned to working groups – Accelerating Pharmacogenomic Research, The Path from Bench to Beside, and Pharmacogenomics and Clinical Trials – and were charged with drafting recommendations. Participants reconvened on the second day to review recommendations.
Current HIV pharmacogenomic knowledge was reviewed by David Haas. Orally administered antiretrovirals undergo absorption, distribution, metabolism, and elimination (ADME), and many ADME genes have functional variants. Non-ADME genes can also affect treatment responses. Table 1 lists well-established associations between genetics and antiretrovirals. Regarding HLA-B*5701 screening for abacavir hypersensitivity,3–6 guidelines recommend that test positivity be documented as abacavir allergy in the medical record,7 but even such a beneficial test took many years to reach practice. Regarding the relevance of CYP2B6 variants for efavirenz,8–13 population differences in genotype frequency largely explain higher plasma efavirenz exposure among populations of African ancestry. This together with an association between CYP2B6 and central nervous system (CNS) adverse experiences8 led some clinicians to incorrectly infer that efavirenz should be avoided in individuals of African descent. This highlights the potential harm resulting from the uninformed use of genetic information. Multiple genetic variants are also associated with nevirapine toxicities.14–17
Regarding strategies to find new associations, Amalio Telenti considered 3 aspects of pharmacogenomic discovery: (1) intermediate versus clinical phenotypes; (2) genetic and genomic approaches; and (3) discovery, replication, and functional validation. There are many functional variants of potential importance in ADME genes, but for most antiretrovirals little is known about effects of genetic variants on toxicity, efficacy, and pharmacokinetics. To demonstrate that phenotypes with outliers are good endpoints, he described the skewed population distribution of lopinavir pharmacokinetics and the discovery of a possibly causative variant in SLCO1B1.18,19 Multiple loss-of-function variants along an ADME pathway may more profoundly affect pharmacokinetics.20 Genomic discoveries in the general population should be translated into the HIV field, including markers of metabolic complications.21,22
Regarding issues in validation, Marylyn Ritchie discussed statistical issues in genomic association studies. Without very large studies, genome-wide association studies (GWAS) may miss true associations when using thresholds derived from Bonferroni correction (eg, P < 5×10−8 for genome-wide significance), but accruing sufficiently large studies is not always feasible. Alternatives include the false discovery rate, permutation testing, and relaxed P-value thresholds, emphasizing effect sizes and independent replication. It is unclear whether replication should be at the level of genes, gene pathways, or gene networks. She introduced issues regarding allelic heterogeneity and population differences and noted that most tagging single nucleotide polymorphisms (SNPs) are not functional. Phenotypes may reflect combined effects of multiple rare variants in different individuals or interactions among common and/or rare variants in the same individual. The importance of phenotyping precision may depend on sample size and other aspects of study design.
Regarding viral genetics and nongenetic factors, Daniel Kuritzkes reviewed the use of laboratory assays for CD4 cells, HIV-1 RNA, viral drug resistance, and chemokine receptor tropism to inform HIV treatment decisions. Factors associated with HIV disease progression in untreated patients include HLA type, CCR5 genotype, and coinfections. Genomics research has enhanced understanding of viral-host interactions. Host genetic markers could potentially be used to stratify populations based on risk of disease progression, informing decisions about when to start therapy. He considered host and viral factors that affect ART response and noted the potential for genetics to elucidate underlying mechanisms of virus-host interactions during ART.
The US Food and Drug Administration's (FDA) role in bringing genetic tests to clinical practice was discussed by Shashi Amur. Several FDA centers govern different aspects of antiretroviral drugs and monitoring: Center for Drug Evaluation and Research (CDER) is involved through drug approval and labeling; Center for Biologics Evaluation and Research (CBER) approves tests for HIV monitoring; and Center for Devices and Radiological Health (CDRH) approves human genetic tests. Genetic test information may be included in initial labeling or added later, with strength of evidence affecting strength of label wording. She emphasized an FDA goal of supporting development of genetic predictors of treatment response and toxicity. The already successful incorporation of some genetic tests into clinical care raises optimism that challenges can be overcome.
Lessons from warfarin studies were recounted by Brian Gage, including the initial implication of multiple genes and a Web-based resource for pharmacogenetic dosing. Initial studies identified an association between CYP2C9*2, *3 and warfarin metabolism, which spurred trials of CYP2C9 genotype-based dosing. Initial studies were not highly successful, in part due to reliance on a single gene. Subsequent collaborations demonstrated that to accurately estimate warfarin dose, dosing equations should include at least 2 genes (VKORC1 and CYP2C9) and clinical factors (eg, age, body surface area). This work fostered www.WarfarinDosing.org, a National Institutes of Health (NIH)–supported site that incorporates genetic and nongenetic factors to guide dosing.
Regarding resource-limited settings, Gary Maartens reminded participants that human genetic diversity is greatest in Africa and that Africa also has the greatest HIV burden. Population genetic structure must be considered when assessing genetic tests. For example, while HLA-B*5701 testing is routine in many countries, this variant is rare in native Africans. It was once argued that CD4 cell testing was not feasible in Africa, but it is now available based on its clinical importance and cost-effectiveness. Increased research in Africa will likely identify novel and relevant genetic associations. Furthermore, knowledge of population frequencies of relevant variants may inform policy.
The power of informatics to improve patient care was discussed by Dan Masys. He recounted how, at one major US medical center, implementation of computerized provider order entry (CPOE) markedly reduced medication prescribing errors. Human genomics is the current archetype for health care complexity. Because handling such complex data exceeds the ability of any practitioner, computerized clinical decision support and electronic medical records will be critical. Genomics dramatically increases data complexity, but failure to use such data will lead to suboptimal patient care. Broadly adopting electronic medical records may help solve this problem.
Regarding clinical trials delivering genetic information, Jacques Fellay noted the importance of large sample sizes, homogenous patient populations, and well-defined phenotypes for genetic association analyses. He recounted the IDEAL study, a prospective trial of hepatitis C virus (HCV) therapies. Most IDEAL participants consented for genetic research. By GWAS, sustained virologic response rates were 80% and 30% among groups with favorable and unfavorable IL28B alleles, respectively.23 Allele frequencies largely explain racial disparities in HCV treatment response. This GWAS already shapes how HCV treatment and drug development is considered, but it was only possible because consent for genomic research was requested in IDEAL. He emphasized that every clinical trial should include genetic consent and DNA collection for future analyses.
Challenges in prospectively testing genetic markers through clinical trials were described by Elizabeth Phillips. The history of HLA-B*5701 screening for abacavir spanned 6 years from discovery to clinical practice. The prospective, randomized PREDICT-1 study definitively established the value of HLA-B*5701 testing among Caucasians and showed the importance of an intermediate phenotype (abacavir skin patch testing) to define true immunologically mediated abacavir hypersensitivity.6 The retrospective, case-control SHAPE study replicated this association in patients of African descent.5 Many immune-mediated drug reactions will involve HLA, but the combination of such a strong association for a problem as prevalent as abacavir hypersensitivity is unlikely for most drugs. The abacavir story exemplified the importance of various study designs, intermediate phenotypes, and validation and ongoing quality assurance of laboratory technologies.
Prospective clinical trial designs relevant to pharmacogenomics were discussed by Heather Ribaudo. Clinical trials provide more robust causal evidence than observational studies. With targeted prospective designs, individuals of known genotype may be prospectively studied specifically to collect information on phenotypes likely affected by genetics. With restrictive/enrichment designs, genetic screening enriches the study population for genotypes of interest and then randomizes participants to an intervention. These designs may require relatively few participants to address targeted questions. She described benefits of a large, phase 3 strategy design in which all potential drug recipients are randomized to genetic screening or not (eg, PREDICT-16). Optimal design depends on the research question. She noted benefits of precise, objective endpoints.
Regarding the cost-effectiveness of genetic testing, Kenneth Freedberg discussed implications of cost-effectiveness analysis applied to clinical trials and strategies of care. Cost-effectiveness is a method of understanding the value of different interventions in HIV, defining the incremental cost-effectiveness ratio in terms of dollars per year of life saved or dollars per quality-adjusted life year saved. He described how higher CD4 counts correlate with lower cost of care. In the United States, HLA-B*5701 testing has been shown to be cost-effective by helping optimize the use of ART. Whether genomic testing will be cost-effective in resource-limited settings will depend on the relative cost of the tests, the prevalence of genomic variances, and cost and availability of different ART regimens.
Regarding diagnostic test development, Christos Petropoulos provided slides describing 2 routes to diagnostic test approval – the Hercep test (Dako North America, Inc., Carpinteria, California, USA) and the Trofile assay (Monogram Biosciences, Inc., South San Francisco, California, USA). Hercep identifies HER2-positive breast cancer, which can be treated with trastuzumab. This standard of care test enables prescribing, with well-aligned positioning of the diagnostic test by drug manufacturer and assay provider. The Trofile assay identifies HIV-1 chemokine receptor tropism and informs prescribing of CCR5 inhibitors. This test is also standard of care but is perceived as a barrier to prescribing. It is best if objectives of pharmaceutical/biotechnology and diagnostic companies can be aligned. Opportunities include reduced health care costs and expanded indications for targeted therapies.
Regarding genetics of complex traits, Teri Manolio described how GWAS has accelerated progress in describing complex traits. She highlighted a Web page summarizing published genome-wide associations (www.genome.gov/gwasstudies/). Lessons from GWAS include surprising signals in unexpected genes, signals in gene "deserts" (regions devoid of protein-coding genes), and individual genes associated with multiple disparate phenotypes. Small genetic odds ratios may reflect contributions of environmental factors. Associations with large effects will be hard to find if causative variants are rare.
Working groups generated specific recommendations. Major recommendations are listed in Table 2.
At the time of clinical trial performance, all future genomic questions cannot be anticipated. Every HIV-related clinical trial should therefore store DNA for future analysis. Consent should encompass the broadest possible scope of genomic assays and clinical phenotypes. In addition, DNA storage should be without time limit, because important genomic questions may arise decades after trial completion.
Some attendees favored a federal mandate that all clinical trials bank DNA and that consent for genetic analyses be required for participation in any trial. The prevailing sentiment among attendees, however, was that these approaches would be prohibited by legal, confidentiality, and other concerns. An alternative is to require that participants have the opportunity to consent "yes" or "no" for future genetic analyses, without their response affecting trial eligibility. The institutional review board (IRB) for at least one US academic center requires that every protocol offers participants such an opportunity unless the investigator justifies otherwise. Mandating such wording nationally, however, could complicate trials enrollment and affect public sentiment about research. In some situations, "opt-out" consenting may be feasible, in which genetic research is allowed unless the participant proactively declines.24
Ethics committees (ECs) and IRBs ultimately decide what is allowed. In the United States, IRB decisions are independent and self-governing. Issues that may cause concern for IRBs include indefinite duration of DNA storage and unlimited scope of analyses. At least some non-US ECs may insist upon narrowly defined scopes of analyses and may be reluctant to allow DNA or genetic data to leave their countries.
A barrier to progress in HIV pharmacogenomics is lack of readily available information regarding existing trial and cohort datasets with broad consent and available DNA. Many genomic analyses occur only following chance interactions between genomic investigators and individuals familiar with particular trials or cohorts. Cataloguing such information would facilitate genetic discovery and replication. A Web-based listing of such studies, including selected available phenotypes, need not be expensive and would include both federally funded and non-federal studies. Individuals familiar with each study would contribute a minimal amount of information. Non-US investigators should be involved from the outset. To provide incentive for data uploads, one suggestion was to limit catalogue queries to individuals who have uploaded data. Web sites already exist that compile information about various aspects of clinical trials and/or pharmacogenomics (eg, ClinicalTrials.gov, PharmGKB, HIV-Pharmacogenomics.org). One option would be to grow the catalogue from an existing site.
Investigators worldwide have interests and expertise directly relevant to HIV pharmacogenomics, but work in relative isolation. This is problematic, as many individual datasets are inadequately powered to identify and/or replicate associations. In addition, because genotype-phenotype associations may vary depending on genetic and environmental factors, associations must be studied in different populations and contexts worldwide. The number and diversity of potential pharmacogenomic questions require involvement of many investigators. An international consortium of investigators could work together to identify the most important HIV pharmacogenomic questions, develop phenotype precision and consensus, combine datasets to address questions beyond the scope of individual groups or datasets, and leverage resources to efficiently complete analyses. Such a consortium could also enhance communication among HIV pharmacogenomic investigators.
Pharmacogenomics investigators are understandably enthusiastic about the potential benefits of their work, given the precedent of a genetic screening test that already improves HIV drug safety and reduces cost (ie, HLA-B*5701 for abacavir hypersensitivity6). Other groups, however, may not share this enthusiasm, perhaps due to concern that genetic information may personally identify patients, that incorporating genomics into clinical care will increase complexity or cost, or that benefits may not reach populations or countries in which discoveries are made. To engage partners in this endeavor, information regarding benefits and challenges of pharmacogenomic research must be effectively shared with persons living with HIV, providers, researchers, policymakers, and the general public worldwide. The consortium mentioned in Recommendation 3 could play a role in disseminating information.
Essential for progress in HIV pharmacogenomics research are robust clinical trial and cohort datasets to merge with genomic data. An underappreciated aspect of this work is the need for personnel with the skills and time for this task. Even with prospective trials and cohorts, considerable data processing may be required to generate clean, well-documented datasets for specific questions. Such work requires individuals who understand subtleties of study design, performance, and data collection. For complex datasets with many possible phenotypes of interest, judgment may be needed to prioritize analyses. There must be sufficient support for all the personnel with complementary expertise needed for these activities. Of note, the preparation of such datasets can be tedious and time-consuming and may not be recognized for academic advancement.
Workshop participants emphasized a number of other points as follows. (1) To define genotype-phenotype associations, various study designs should be pursued in parallel, not sequentially (eg, observational and prospective studies, studies of clinical outcomes and intermediate phenotypes, studies in different populations and contexts, etc). (2) When observational evidence of genetic association is sufficiently strong, prospective clinical trials to test genetic predictors may not be required. However, treatment guidelines are most strongly affected by prospective trials, and information in different populations is required to define generalizability. (3) Cost-effectiveness modeling plays an important role in assessing genetic markers and the feasibility of application to clinical practice. (4) Both positive and negative findings from genetic association studies should be presented. (5) Genetic studies should consider nongenetic and ecological factors (eg, nutritional status, medication adherence, concomitant medications, and concomitant illnesses). (6) The most relevant phenotypes should be carefully chosen based on clinical impact. Considerations include drugs that are widely used, and populations in which they are prescribed. (7) Identifying genetic predictors of adverse events is most critical, but predictors of virologic response would also be of considerable interest. (8) Pharmacogenomics studies should incorporate pharmacokinetic analyses. Pharmaco-kinetic data enhance interpretation of genetic association studies, and predictors of drug disposition could inform dosing schedules. (9) Pharmacogenomics research benefits from an understanding of pharmacokinetic-pharmacodynamic relationships. (10) As much information as possible should be gleaned from extant data and specimens through association analyses, cost-effectiveness analyses, and value-of-information analyses. (11) Merging data from various clinical trials and cohorts would be facilitated if studies routinely and uniformly collected minimum sets of key variables. (12) Results, implications, and generalizability of genetic association studies may be context dependent. For example, some studies relevant to resource-limited countries may not be relevant to other countries. (13) A potential application of pharmacogenomics in resource-limited countries is to predict whether drugs are likely to be safe for their population. For example, if a reliable genetic predictor of drug toxicity is identified, that drug could be avoided in populations with high allelic frequencies of the predictor. (14) Although most genetic markers may not reach clinical application, much may be learned from genetic studies that elucidate underlying mechanisms of disease pathogenesis.
The views expressed in written conference materials or publications and by speakers and moderators at HHS-sponsored conferences do not necessarily reflect the official policies of the US Department of Health and Human Services nor does mention of trade names, commercial practices, or organizations imply endorsement by the US Government. This project has been funded in whole or in part with federal funds from the National Institute of Allergies and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, under contract no. HHSN272200800014C.
The workshop entitled, Pharmacogenomics – A Path Towards Personalized HIV Care, was supported by the National Institute of Allergy and Infectious Diseases and the NIH Office of AIDS Research. This work was supported in part by the AIDS Clinical Trials Group (grants AI68636, AI38858, AI68634, and AI38855). Participants were also supported by the following: grants AI069439, RR024975, and AI54999 (DWH); AI51966 (RMG); RR024996 (Cornell CTSC); RR69419 (CTU); Swiss National Foundation 324730–124943 (AT); HL097036 (BFG); AI64086, AI36214, AI69432, and CHRP MC08-SD-700 (RH); AI069472 (DK); HL065962 and AI077505 (MDR); AI42006 and AI085736 (KAF).
The following individuals participated in this workshop: Rahel Abebe, MHS (HJF-DAIDS, Bethesda, MD); Shashi Amur, PhD (FDA, Silver Spring, MD); Peter Anderson, PharmD (University of Colorado Denver School of Pharmacy, Aurora, CO); Bradley Aouizerat, PhD (University of California San Francisco School of Nursing, San Francisco, CA); Jing Bao, MD, PhD (HJF-DAIDS, Bethesda, MD); George Bishopric, MD (Community Representative, ACTG, Fort Lauderdale, FL); Sarita Boyd, PharmD (National Cancer Institute, Bethesda, MD); Susan Brobst, PhD (NIAID, Bethesda, MD); Renee Browning, MSN (HJF-NIAID, Bethesda, MD); David Burns, MD, MPH (NIAID, Bethesda, MD); Stacy Carrington-Lawrence, PhD (NIH, Rockville, MD); Ling Chin, MD, MPH (NIAID, Rockville, MD); Michael Court, BVSc, PhD (Tufts University School of Medicine, Boston, MA); Steven Deeks, MD (University of California San Francisco, San Francisco, CA); Marjorie Dehlinger, DNSc (NIH, Bethesda, MD); Vanessa Elharrar, MD, MPH (NIAID, Bethesda, MD); Mariam Eljanne, PhD (NIAID, Bethesda, MD); Jacques Fellay, MD (University of Lausanne, Lausanne, Switzerland); Kenneth A. Freedberg, MD, MSc (Massachusetts General Hospital, Boston, MA); David Flockhart, MD, PhD (Indiana University, Indianapolis, IN); Andrea Foulkes, ScD (University of Massachusetts, Amherst, MA); Lawrence Fox, MD, PhD (NIAID, Bethesda, MD); Tia Frazier (NIAID, Bethesda, MD); Brian Gage, MD (Washington University, St. Louis, MO); Ben Grady (Vanderbilt University, Nashville, TN); Roy M. Gulick (Weill Medical College of Cornell University New York, NY); Misrak Gezmu, PhD (NIH, Bethesda, MD); David W. Haas (Vanderbilt University, Nashville, TN); Richard Haubrich, MD (University of California San Diego, San Diego, CA); Todd Hulgan, MD, MPH (Vanderbilt University, Nashville, TN); Patrick Jean-Philippe, MD (HJF-DAIDS, Bethesda, MD); Peter Kim, MD (NIAID, Bethesda, MD); Daniel Kuritzkes, MD (Brigham and Women's Hospital and Harvard Medical School, Boston, MA); Saye Khoo, Professor (University of Liverpool, Liverpool, United Kingdom); Karin Klingman, MD (NIAID, Bethesda, MD); Awewura Kwara, MD, MPH&TM (Brown University, Providence, RI); Scott Letendre, MD (University of California San Diego, San Diego, CA); Jonathan Li, MD (Brigham and Women's Hospital and Harvard Medical School, Boston, MA); Chenglong Liu (Georgetown University, Washington, DC); Gary Maartens (University of Cape Town, Cape Town, South Africa), Teri A. Manolio, MD, PhD (NIH, Bethesda, MD); Dan Masys (Vanderbilt University, Nashville, TN); Julia McEachern, MHS, PA-C (Medco Health Solutions, Inc., Bethesda, MD); Paul McLaren, PhD (Brigham and Women's Hospital, Harvard Medical School, Boston, MA); Judi Miller, RN (NIAID, Bethesda, MD); Jon Mirsalis, PhD (SRI International, Menlo Park, CA); Mostafa Nokta, MD, PhD (National Cancer Institute, Bethesda, MD); Naomi O'Grady (Illumina, San Diego, CA); Igho Ofotokun, MD, MSc (Emory University, Atlanta, GA); Andrew Owen, PhD (University of Liverpool, Liverpool, United Kingdom); Christos Petropoulos, PhD (Monogram Biosciences, South San Francisco, CA); Elizabeth Phillips, MD (Sir Charles Gairdner Hospital, Royal Perth Hospital, Murdoch University & University of Western Australia, Perth, Australia); Alice Pau, PharmD (NIAID, Bethesda, MD); Carla Pettinelli, MD, PhD (NIAID, Bethesda, MD); Sonia Qasba, MD, MPH (Tuberculosis Control Program, Montgomery County, MD); Heather J. Ribaudo, PhD (Statistical Data Analysis Center, Harvard School of Public Health, Boston, MA); Marylyn D. Ritchie, PhD (Vanderbilt University, Nashville, TN); Sarah Read, MD (NIAID, Bethesda, MD); Keisha Robinson, MBA, MPM (Medco Health Solutions, Inc., Bethesda, MD); Jody Sachs, DPM (National Center for Research Resources, Bethesda, MD); Bruce Schackman, PhD (Weill Cornell Medical College, New York, NY); Helen Schiltz, PhD (NIAID, Bethesda, MD); Stuart Shapiro, MD, PhD (NIAID, Rockville, MD); Gerald Sharp, DrPH (NIAID, Bethesda, MD); Phumla Sinxadi, MBChB (University of Cape Town, Cape Town, South Africa); Nevilla K. Smith, RN (Henry M. Jackson Foundation, NIAID, Bethesda, MD); Wendy Stevens, MD, MMed, FCPath (University of the Witwatersrand, Johannesburg, South Africa); Philip E. Tarr, MD (University of Basel, Bruderholz, Switzerland); Amalio Telenti, MD, PhD (University of Lausanne, Lausanne, Switzerland); Charles Venuto, PharmD (University at Buffalo, University of Rochester, Rochester, NY); C. William Wester, MD (Vanderbilt University, Nashville, TN); Sharon D. Williams (NIAID, Bethesda, MD); Carolyn Williams, PhD, MPH (NIAID, Bethesda, MD); Chery Winkler, PhD (National Cancer Institute, Frederick, MD); Hao Zhang, MD (NIAID, Bethesda, MD).
Potential Conflicts of Interest
David W. Haas: Principal Investigator for research grants to Vanderbilt from Bristol Myers Squibb, Boehringer Ingelheim, Merck, Gilead Sciences. Daniel Kuritzkes: Consultant to and/or received research support from Abbott, Avexa, Boehringer-Ingelheim, Gilead, GlaxoSmithKline (GSK), Merck, Oncolys, Roche, Siemens, Tobira, Vertex, ViiV, Viro-Statics and VIRxSYS. Marylyn D. Ritchie: Consultant for Boehringer Ingelheim. Elizabeth Phillips: Honoraria and consulting fees from ViiV Australia, Merck Pty Ltd, and Tibotec. Christos Petropoulos: Employee of Monogram Biosciences, South San Francisco, CA. Roy M. Gulick: Ad hoc consultant for Bristol-Myers, Gilead, GSK, MedImmune, ViiV, and Virostatics, and as Principal Investigator for research grants to Weill Cornell from Merck and Pfizer. Richard Haubrich: Received honoraria or consultant fees from Abbott, Bristol-Myers Squibb, Gilead Sciences, GSK, Merck, Monogram, Pfizer, Roche, Tibotec, and ViiV and research support (to UCSD) from Abbott, GlaxoSmithKline, Merck, Pfizer, and ViiV. No potential conflicts of interest: Shashi Amur, Brian Gage, Gary Maartens, Dan Masys, Jacques Fellay, Heather J. Ribaudo, Kenneth A. Freedberg, Teri A. Manolio, Peter Kim, Marjorie Dehlinger, Rahel Abebe, and Amalio Telenti.
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


text: I will be in Mexico City for 9 days over Christmas vacation, with my husband and 14-year-old son. We'll spend four or so days in the middle of the week making side trips--we're thinking Teotihuatican, Las Estacas, Taxco--and the rest of the time in the DF. I'm looking for restaurant suggestions--simple, local, delicious, affordable, not too touristy. While in the DF, we'll be staying at Casa Gonzales, which I think is in the north part of the Zona Rosa (I'm not familiar with the city), so nearby suggestions would be great... though we'll be exploring farther afield, so other locations would be appreciated, too.


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Handel's Messiah Sing-a-long
Messiah 2016
Paul Featherstone, Directing
Christie Jones, Soprano
Jan Priddy, Alto
Tom Williams, Tenor
John Frankhauser, Bass
The Messiah Orchestra
The Messiah Choir
The Sing-a-long Choir
When: Sunday, December 11th, at 4:00PM
How to Participate: Three Options
1) Attend the concert at 4PM on December 11. Arrive early, seats fill fast!
2) Sing-along on the choruses
a) It is open to all! Please arrive by 2:15 PM to be seated.
b) The rehearsal will begin promptly at 2:30 PM. Scores will be available for checkout if you do not have your own.
3) Go deeper into the music of the Messiah & sing with the choir on the chancel (i.e. The Messiah Choir)
a) Rehearsals with the Chancel Choir are in the Choir Room, third floor of the church
b) Please plan to attend 4 of the 5 regular rehearsals, and the dress rehearsal
c) Rehearsals are:
i) Nov 3 (7-8PM)
ii) Nov 10 (7-8PM)
iii) Nov 17 (7-8PM)
iv) Nov 21 (7-8pm)
v) Dec 1 (7-8PM)
vi) Dec 8 (7-10PM Dress Rehearsal)
d) We would love to have 20-25 singers join with the FPC choir on the chancel!!!!
Questions? Contact John Frankhauser at firstname.lastname@example.com
What (sing-a-long choruses are in bold):
Part I
Comfort ye
Every valley
And the glory of the Lord (Chorus)
Thus saith the Lord
But who may abide the day of His coming?
And he shall purify (Chorus)
Behold a virgin shall conceive
O thou that tellest good tidings to Zion (Chorus)
For behold, darkness shall cover the earth
The people that walked in darkness
For unto us a child is born (Chorus)
There were shepherd abiding in the field
And lo, the angel of the Lord came upon them
And the angel said to them
And suddenly there was an angel
Glory to God
Than shall the eyes of the blind be opened
He shall feed his flock
Part II
He was despised
Surely He hath borne our griefs (Chorus)
And with His stripes we are healed (Chorus)
All we like sheep (Chorus)
Pastoral Symphony
Thy rebuke hath broken His heart
Behold, and see if there be any sorrow
He was cut off from the land of the living
But Thou didst not leave His soul in hell
Lift up your heads, o ye gates (Chorus)
How beautiful are the feet of them
Their sound is gone out (Chorus)
Why do the nations so furiously rage together?
Hallelujah (Chorus)
Part III
I know that my redeemer liveth
Since by man came death (Chorus)
Behold, I tell you a mystery
The trumpet shall sound
Recitation from Revelation 5
Worthy is the Lamb/Amen (Chorus)
Admission is Free
A freewill offering will be taken to cover the expenses of this concert.
Support Messiah 2016 with a donation/gift online (all proceeds go directly to fund this annual event)
We look forward to seeing you on December 11th!
For driving and parking directions, click here


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Baking chicken in sauce is an easy and flavorful way to cook dinner at the end of a long day. Depending on the sauce you choose, it can also be healthier than cooking on the stove or deep-frying because baking uses less fat. Choose a pesto, teriyaki, Alfredo or tomato sauce; the method is the same, so just change the sauce to suit your mood. Boneless chicken breasts with and without skin work equally well in this preparation.
Things You'll Need
- 2 chicken breasts
- Plastic wrap
- Small skillet
- Baking dish
- Olive oil
- Your favorite sauce
Preheat the oven to 350 degrees. Place the chicken breasts between two pieces of plastic wrap. Smooth any air bubbles out toward the edges.
Pound the chicken breasts flat with a small skillet. Aim for uniform thickness rather than any specific measurement. Flattening the chicken allows it to bake evenly and prevents dry, overcooked edges and a raw, pink interior.
Rub olive oil lightly all over the interior of a baking dish. Place the pounded chicken breasts in the dish. It's OK if the chicken breasts touch slightly, but overlap them as little as possible.
Pour your favorite sauce over the chicken breasts. Spread out the sauce so that it covers the chicken evenly. This will help keep the chicken moist as it bakes.
Bake for 30 minutes, or until the chicken is cooked through and no pink remains. Serve immediately over pasta, rice, or vegetables.
Tips & Warnings
- If you're multiplying this recipe for four or more people, use a second baking dish to ensure that there's enough space for the chicken to cook thoroughly. If the chicken overlaps too much, it will take longer to cook.
- Many store-bought sauces contain a lot of salt, so you may not need to add more to the chicken.
Related Searches
- "The Professional Chef (Eighth Edition)," The Culinary Institute of America; 2006
- Photo Credit Polka Dot Images/Polka Dot/Getty Images
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7 Endorsements
About Ms. Flora Moon
Consultant and communications professional who employs change management skills to transform organizations. Expertise includessustainable development (international and national) and media (all formats - wireless and mobile content, broadcast and media, cable and digital tv technologies, content and creative direction). She is the founder of the non profit organization, Sustainable Development Flow Fund, and serves on the board of BluePrint Houston.
If you notice offensive or incorrect information, please contact us.


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All Android applications categories
De-stress, relax, and re-center with RELAX by Cranium Crunches.
Reduce your stress levels with Guided Relaxation.
• Learn to focus on your breathing.
• Relax your body one step at a time.
• Take a guided journey to far off places.
Re-charge your brain with quick (less than 3 minute) yoga mini-exercises.
• Increase blood flow to the brain.
• Reduce stress and nourish your brain.
Record and view your journey to a more relaxed and centered attitude with the built-in journal.
• Record mood and thoughts after each exercise.
• Enter thoughts, intentions, goals, and aspirations at any time.
Learn about the toll stress takes on your body and techniques on how to reduce that stress in everyday
KEYWORDS: yoga, meditation, guided relaxation, de-stress, relax, RELAX by Cranium Crunches, brain
health, brain healthy activities,relaxation
from 5 reviews
Download Relax by Cranium Crunches Free
Free - V1.2.2 - 10M
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We help you locate a Prudhoe oboe teacher. Oboe tuition are a brilliant method to learn a stimulating new hobby, acquire a new skill and gain confidence with oboe. Use our site to search for Prudhoe oboe tutors and select which best suits your needs so you can start your oboe tuition in Prudhoe straight away!
This is the best place to contact Prudhoe oboe teachers in the UK, helping you discover Prudhoe oboe lessons close to you and Prudhoe tutors to assist with any instrument such as piano, violin or guitar. We can help you find Prudhoe oboe tuition or a one-to-one Prudhoe oboe teacher to prepare for oboe exams and improve your oboe skills! Our search will order Prudhoe oboe tutors local to you according to their tuition charges and proximity to you.
If you are a oboe teacher wishing to offer oboe tuition services in Prudhoe or anywhere else across the UK, please register with First Tutors: Music or learn about us here. Becoming a Prudhoe oboe teacher is a brilliant way to re-affirm your own knowledge through giving oboe tuition while helping others, all in the Prudhoe area!


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Apostolicam Actuositatem is the Second Vatican Council's Decree on the Apostolate of the Laity. It was approved by a vote of 2,340 to 2 of bishops assembled at the Council, and promulgated by Pope Paul VI on November 18, 1965. The title is Latin for "Apostolic Activity," which is from the first line of the decree, as is customary with significant Catholic documents.
The decree defines the mission of the lay Christian faithful to both "lead non-believers to the faith and to instruct, strengthen, and encourage the faithful to a more fervent life". [6].
"God's plan for the world is that men should work together to renew and constantly perfect the temporal order." [7].
The numbers given correspond to the section numbers within the text.
- Introduction (1)
- The Vocation of the Laity to the Apostolate (2-4)
- Objectives (5-8)
- The Various Fields of the Apostolate (9-14)
- The Various Forms of the Apostolate (15-22)
- External Relationships (23-27)
- Formation for the Apostolate (28-32)
- Exhortation (33)
- English translation of text at the Vatican
- Original Latin text at EWTNid:Apostolicam Actuositatemsw:Apostolicam Actuositatem
la:Apostolicam Actuositatemsk:Apostolicam Actuositatem sl:Apostolicam Actuositatem sv:Apostolicam Actuositatem


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Product Spotlight
Featured Research
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Shell Cleaning Up
More than 100 volunteers unite as part of beach cleanup in Santa Monica.
SANTA MONICA, Calif. -- In support of the Ocean Conservancy's International Coastal Cleanup, more than 100 Shell employees and Shell Youth Training Academy students turned out to clean up Santa Monica Beach Saturday.
Celebrating its 17th annual cleanup, The Ocean Conservancy's objective is to remove trash from beaches while also collecting valuable information on the amount and type of debris.
While cleaning up Santa Monica Beach, Shell participants will be encouraged to be "data detectives" by examining unique and peculiar trash and to look for clues that indicate where the debris originated. Clues, such as the name of a company or a city on discarded waste, are crucial when it comes to tracing pollution sources.
"Shell is committed to being a good corporate citizen and takes a special interest in the areas in which Shell people live and work," said Shell Oil Company President Rob Routs. "Our volunteers are truly dedicated and the incredible turnout we have for this event is evidence of that."
In addition to the Santa Monica cleanup effort, 1,300 volunteers from Houston-based Shell Oil and its affiliates will spearhead similar beach revitalization efforts in Martinez, Calif.; Texas; Michigan and Louisiana.


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Wow White Room Escape game
Wow White Room Escape is another new point and click room escape game from You are locked inside a white room. No one is near to help you out. Escape from the white room by finding items and by solving the puzzles. Use your best escape skills. Good luck and have fun!
Wow White Room Escape, play free Room Escape games, related games and updates online. Added on
Author: wowescape 59
Here are some more related games in Room Escape category. Also you can jump to other category using box above.
Related games
- Wow Modern Escape
- Wow Home Escape
- Wow Modern Kids Room Escape
- Wow Mansion Escape
- Wow Dark Room Escape
- Wow Office Lounge Escape
- Wow Bar Room Escape
- Wow Valentines Room Escape
- Wow Lab Room Escape
- Wow Royal Room Escape
- Wow Yoyos Escape
- Wow Penthouse Escape
- Wow Untidy Escape
- Wow Painting Room Escape
- Baby Escape 2
- The Cross Adventure Plus
- Gazzyboy Amusement Park Escape
- Gazzyboy Insane escape
- Gazzyboy Robot Escape
- Gazzyboy Fire house escape
- Gazzyboy Makeup Room Escape
- Gazzyboy Electronic showroom escape 2
- Gazzyboy Clock showroom escape
- Gazzyboy Riddle beach house escape
- Gazzyboy Escape From The Crash
- Gazzyboy Jurassic park escape 2
- Gazzyboy House Of Wax Escape
- White Zone


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Distilled Spirits
Distilled Spirits (less than 190 proof) manufactured within Georgia are taxed at 50 cents (excise tax) per liter. Distilled spirits manufactured outside Georgia are taxed at $1 per liter. Alcohol (any product over 190 proof) manufactured within Georgia is taxed at 70 cents per liter and alcohol manufactured outside of Georgia is taxed at $1.40 per liter. Some localities also collect a local tax, which can be up to 22 cents per liter.


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Just a Taste: Destination BBQ at new 2M Smokehouse
Updated 2:39 pm, Monday, December 5, 2016
Where: 2731 S. W.W. White Road, 210-885-9352, Facebook: 2M Smokehouse
Hours: 11 a.m. to 7 p.m. or until sold out Thursday-Sunday
On the menu: Brisket, pork spare ribs, pulled pork and turkey, $9-$10 by the half-pound; sausage, $5.50 a link; two-meat plate with two sides, $15; tacos, two for $8; sandwiches, $8-$10; sides, $3; tres leches cake, $7.
Fast facts: After a series of barbecue trailer pop-ups this summer, high school friends and native San Antonians Esaul Ramos and Joe Melig opened 2M Smokehouse on Dec. 3 in the former home of Cowgirls Cafe. Ramos trained with top-flight pitmaster John Lewis at La Barbecue in Austin, and he's cooking on an oak-fired pit that Lewis custom-built for him. 2M is named after the founders' Melig and Marquez families, and the shop is building its own family legacy: Ramos runs the pits; his girlfriend, Grecia Contreras, bakes their tres leches cakes; Melig works the business side, and his wife, Selah Melig, chalks all the menus by hand. 2M plans to add fajitas on Fridays and beef ribs on Saturdays.
Impressions: Barbecue is a destination thing in Texas, a game of which city wears the crown, and who's willing to drive there to get it. With 2M Smokehouse, it could be San Antonio's turn. This is the kind of full-fat, velveteen, salt-and-pepper brisket with bark and bite that made Franklin Barbecue, Snow's BBQ, Kreuz Market and Louie Mueller Barbecue famous, with a twist of garlic and cumin.
Ramos will make his own name by crafting pork sausage with Oaxaca cheese and poblano pepper that's as subtle as any artisan dish, and his pulled pork — in coral-colored, barky nuggets of fat and lean — is already better than much of what I've eaten in the pulled-pork motherland of South Carolina. 2M's "barbecue syrup" will polarize barbecue people who swear by sauce or smoke. No matter. I'd drink that peppery molasses glaze in my coffee and pour it on pancakes, and it turns great brisket into brisket for dessert. I call that a balanced diet.


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News By Tag
Industry News
News By Place
Industry News
Brian Henry Attains CIC Designation
Earners and maintainers of CIC designation, such as Henry, have demonstrated professional competence through a series of rigorous written examinations which focus on all major fields of insurance, agency operations, and insurance management. This achievement signifies a commitment to continuing education, required of all those who have earned the CIC designation.
The CIC Program has been the insurance industry's premier, proven source for practical, real-world education since 1969. Approved for state continuing education credit across the nation, the five CIC institutes are:
· Personal Lines
· Commercial Casualty
· Commercial Property
· Life & Health
· Agency Management
"The CIC Program is an invaluable tool designed to further the education of insurance professionals,"
Barker Phillips Jackson is one of the largest independent insurance agencies in Southwest Missouri. The firm has been headquartered in Springfield, Missouri since 1960 with satellite locations in Rolla and West Plains. To learn more, go to http://www.bpj.com/
Tom Montileone
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Nitric Oxide Sorption by Calcareous Soils: III. Effects of Temperature and Lack of Oxygen on Capacity and Rate1
- R. J. Prather and
- S. Miyamoto2
The sorption of NO by oven-dry soils from dry air (relative humidity < 5%) containing a concentration of 1.5% NO by volume decreases exponentially with increasing temperature from 24 to 120C. From a moist stream (relative humidity > 95%), both NO and H2O sorption capacities and rates decrease with increasing temperature from 24 to 77C. The sorption capacity of NO relative to H2O changes little, while the relative sorption rate to that of H2O decreases markedly when the temperature increases from 24 to 36C but not for higher temperatures. The lack of gaseous oxygen severely inhibits the sorption of NO from both dry and moist nitrogen gas streams.Please view the pdf by using the Full Text (PDF) link under 'View' to the left.
Copyright © .


text: Bone Rhythms is a minor Garou rite. The Garou taps out a special rhythm to honor his or her totem. The sticks are typically bone but can be of any material. This ritual temporarily gives an extra die to any one roll in the Umbra. Once the die has been used, the Garou must let the energies regenerate for three days and do the rite again to reknew it.


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Baroonda was a planet of varied geography. It was host to several podracing tracks which passed through many diverse locations, including volcanoes, swamps, wide, sandy beaches, spectacular waterfalls, thick jungles, sulfur geyser fields, and plateau-top cities. Some of the inhabited moons of Baroonda included Dirama, Pitrono, Metrmal, Nicale, and Promanda.
Around 32 BBY, Trade Federation C-9979 landing craft were seen in the skies of Baroonda. This began several rumors about Trade Federation activities on the planet; and one of its eighteen moons was suspected of hosting the CIS, although none of the rumors were substantiated. Podracing was a very popular sport on the planet, and there were several well-known tracks, including Baroo Coast, Grabvine Gateway, Fire Mountain Rally and Inferno.


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What's the big deal (just kidding – it's a big deal)? Don't liberal politicians do this sort of thing all the time?
Teen who faked cancer faces theft charges
The good news is she doesn't have cancer.
The bad news is she faces criminal charges.
The Horizon City Police Department has filed criminal charges against a young
woman who raised the sympathy of a community along with thousands of dollars in
donations by claiming she was dying from cancer.
Police officials said Tuesday that a three-month investigation found that
Angie Gomez, 18, had no record of having leukemia, as she claimed while
allegedly collecting about $17,000 in donations.
Gomez is accused of theft by deception over $1,500, a state jail felony. The
case has been sent to the district attorney's office as a non-arrest, meaning
she has not been taken into custody.
"There is nothing to indicate she had cancer. There is no medical records, no
doctors," Detective Liliana Medina said. The investigation determined there were
no other suspects in the case, Medina said.
Gomez had an infectious smile, a positive outlook and a tragic tale. Gomez
was a senior at Horizon High School when her story unfolded earlier this year.
She graduated in June.
Gomez told a tale of having leukemia as a child and was now fighting a fatal
resurgence of the cancer. She told classmates that doctors in January had given
her six months to live. Classmates and teachers at Horizon High School rallied
around her and held fundraisers, and then she was invited to speak at other
read the rest at elpasotimes.com


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Question: I recently purchased a second home in Pennsylvania. My two favorite local FM stations (KCSM and KQED) both offer streaming radio programming. I can receive these signals on my home computer but the sound quality is terrible, especially for music. I would like to receive these stations back East and I am going to buy an iPad or laptop to use there. What equipment can I use to get decent Internet radio sound quality? - L.B., Belmont, Calif.
Answer: The two most likely causes for the bad sound quality are poor speakers or a poor signal. It could be one or both. Here are some ideas for you.
Much like flat-panel televisions, most computers have poor sound quality. Your first step is to connect better speakers to the audio output or headphone port, or use a Bluetooth speaker. One Bluetooth speaker that would be an especially good match for your tablet or a laptop is the Definitive Technology Sound Cylinder. It has a grip that attaches it to your tablet to make it seem all one piece. You can carry the tablet around with the Sound Cylinder attached, or use its built-in kickstand to hold the tablet vertically for watching television and videos. I use Dish's Hopper with Sling DVR to transmit live and recorded television to my iPad with a Sound Cylinder to use as my kitchen television. If your TV service offers remote streaming this is a wonderful way to enjoy TV everywhere in the house. The Sound Cylinder's grip also can attach to the top of a laptop. It's a beautiful sounding, beautifully made peace of gear for $199. (definitivetech.com/
It also could be the signal the stations are feeding through the Internet is low bit rate sound. I've heard wide variance in the sound quality of Internet radio stations. At their best they can sound quite good, but the worst are horrible. You can look up the bit rates of the specific stations you are interested in on the Shoutcast Radio directory. There you will see bit rates from 32mbps (awful) to 128mbps (equivalent to an iTunes music file). I have seen a few stations using 192mbps bit rate streams (virtually hi-fi). The AAC+ stations may sound even better if your hardware supports it. (shoutcast.com)
If the station is using a low bit rate you won't be able to achieve great sound. Regardless of the bit rate you can make sure that the gear you have is wringing the maximum fidelity out of whatever is there. If you want to take it beyond a portable speaker and listen to Internet radio on a home sound system, check out the Mass Fidelity Relay. Relay is a convenient way of having access to all the music on the Internet as well as the music on your smart device, putting music selection and volume control in the palm of your hand. Best of all, Relay is a true high-fidelity device with premium components such as expensive, high-end digital-to-analog converters (DACs.) Using these DACs and premium circuitry, Relay preserves sound quality to a degree that other Bluetooth wireless systems cannot. It's a great way to add Internet radio to a high-quality sound system. Relay is $249 with a 60 day risk-free trial.
Contact Don Lindich at soundadviceblog.com and use the "submit question" link on that site.
Distributed by MCT Information Services


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Apple Pickle
Brief Description
Apple pickle is a famous and delicious pickle recipe which is quite easy in preparation. Follow this simple method to learn the preparation of Apple Pickle.
|Preparation Time
|15 minutes
|Cooking Time
|10 minutes
|Number of Serves
Ingredients For Apple Pickle
- 10 gram Red chilli powder
- 400 gram Green apple
- 10 gram Sugar
- Half cup Vinegar
- Half teaspoon Turmeric powder
- 1 tablespoon Cumin powder
- 1 tablespoon Roasted Coriander seeds
- 1 teaspoon Mustard seeds
- Add Salt according to taste
For Tempering:
- 1 teaspoon Cumin seeds
- One teaspoon Mustard seeds
- 1 teaspoon Ginger and garlic paste
- ½ teaspoon Nigella seeds
- ½ teaspoon Fenugreek seeds
- Half cup Oil
How To Make Apple Pickle
- Firstly wash the apple properly and then leave it to dry for sometime.
- Cut the apple in horizontal portion in half inch pieces.
- Now mix mustard powder, coriander, cumin, salt, sugar, vinegar and turmeric altogether in a bowl and leave it aside for sometime.
- Now to prepare tadka take a kadhai and heat some oil in it and then start frying cumin and mustard seeds in it.
- Now add fenugreek and nigella seeds in wok and just after a few seconds add ginger and garlic mixture in it and then take it off from heating and allow it to cool.
- Put this prepared mixture on apple pieces.
- Finally put this prepared recipe in clean and dry airtight jar.
Some Useful Tips
- If you want apples in the pickle recipe to be crunchy then cook it for just about 5mins otherwise cook it completely.
- If apples are not too sour then add some lime juice to it.
- To make the preparation simpler add mustard powder instead of mustard seeds
Other Similar Recipes
- Apple Juice
- Apple Chips


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8 Heroes - [Urashima Taro]
"Have you ever seen Rin Gin, the Palace of the Dragon King of the Sea, Urashima?"
The fisherman shook his head and replied; "No; year after year the sea has been my home, but though I have often heard of the Dragon King's realm under the sea I have never yet set eyes on that wonderful place. It must be very far away, if it exists at all!"
"Is that really so? You have never seen the Sea King's Palace? Then you have missed seeing one of the most wonderful sights in the whole universe. It is far away at the bottom of the sea, but if I take you there we shall soon reach the place. If you would like to see the Sea King's land I will be your guide."


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A Shopping Extravaganza
Come shopping with us at the most elaborately decorated, soaring indoor shopping space of the nineteenth century.
Papal Vestments: Clothes Make the Man
In 428, Pope Celestine I rebuked some of his priests for wearing "modern" clothing. We take a look at the vestments which reveal the Pope's singular status.
What's all the Hoopla?
Discover the lengths nineteenth-century fashionistas went to when trying to keep up with the latest fashions.
Getting Dressed
We take you behind the scenes at a historical museum as curators and conservators dress mannequins and prepare for an exhibit on Downton Abbey style clothes (Part I).
Not For Old Fogies
Roll down your stockings as Susan Ferentinos introduces you to flappers, their flippers, and one of their favorite magazines.
Tuvan Textiles
Tuvans claim that a masterful man forges silver and a crafty woman does needlework. UHP interviews a Tuvan artist about her traditional needlework.
Before the Whiteout
Vera Wang shocked fashionistas everywhere with her red wedding gowns this spring. But she was really just being traditional.
Down with the Veil!
Douglas Northrop examines the Soviet Union's campaign to liberate Central Asian women from wearing the veil and the responses of many Muslim women.
Dirty Laundry
Over time, loads and loads of it have accumulated. Orville Butler comes clean about how women in early modern Europe did their laundry.
Not Just Any Cloth
Jessica Achberger weaves together the complex history of Kente cloth.
Out for a Drive
Shake off your dusters and drive into the past to take a peek at the special clothes motorists wore in the early days of motoring.
Lords of Fashion
Click your heels as we take you back to a time when even the color of your heels revealed your social status.
Out for a Drive: Motoring Clothes
Get out your dusters! We drive into the past to explore the special clothes motorists wore in the early days of motoring.
High-Flying Fashion
Michael R. Lynn opens the closet doors to expose the soaring fashions of the late eighteenth century.
Fashioning the New Woman
Slip into your best clothes as we take you in
through the front door for a sneak peak at a new exhibit that explores how and why women's fashions changed during the Downton Abbey era (Part II).
That's The Way They Liked It
Put on your dance shoes and hustle along with Diana Mankowski as she gets down with the groovy fashions of the disco era.
Seventh Heaven
An evening event was a success only if the room was so crowded and overheated as to cause men and women to faint. We give you a voucher to Europe's hottest dance club.
How Much is That Dress Worth?
Where did dollar princesses like the fictional Cora, Lady Grantham, go shopping? Join us on our shopping spree as we meet with one of the leading designers of the nineteenth century.
Blue Mondays
How did fashionistas in the past keep their clothes clean? Orville Butlers discusses the pains and pleasures of laundry day and the brute strength required to clean one's clothes.
Another Load of Laundry
Rebecca Pulji takes a look at how French women were liberated from this unpleasant task during the twentieth century.


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Where is the best area on the ship to book a stateroom? Are some areas better to reduce the chance of seasickness? Where are the engines? Are they really loud? As you can tell, I've never cruised before and I looking for any helpful hints! Thanks!!
Recent ActivityView all Cruises activity »
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Best Location For Stateroom
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Middle to front is better than back. Outside cabin is nice because you have a window but inside works great if you want to save money. Some people think the higher floor the better, but we've been on floors 3 and up and have not had any problem with sea sickness or loud engine noises. There are usually sea-sickness patches available, depending on what cruise line. Something we learned the hard way: look at the floor plan of the ship, each level. Make sure your stateroom is not directly above or below a lounge. You might hear loud noises all night! If you don't find that information on-line (again, depending on the cruise line) you can request a brochure or booklet from the cruise company, or get a free one from a travel agent. Also, it's usually cheaper to book through a "cruise only" agency - look around on the internet and compare prices. It can vary quite a bit. Sometimes a travel agent can match the price, but we've always gotten better deals on-line. Good luck - cruising is a great vacation!
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The least motion in a ship is felt in its center section.
Picture in your mind a playground see-saw. If you are at either end you experience a lot of up and down motion, if you are in the center, you experience almost no up and down motion, only a little rocking.
Most people will recommend a cabin in the middle of the ship on a lower deck to minimize motion (and sea sickness). Hope this helps.
To avoid noise, look for a cabin that is away from noisy public areas, like show rooms, the casino, etc.
The ships engines (on most newer ships) are below the crews decks, which are below all passenger levels, so you are not likely to hear them. Enjoy your cruise!
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Just another thought...you probably don't want the deck just below the promenade deck, especially if the ship has the jogging track on that deck. I've had people tell me that you can hear the joggers/runners overhead. IMO I wouldn't want the promenade deck either with an outside cabin, I like my privacy! But wherever you are you will have a great time! Have lots of fun.
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Thank you so much for your helpful advice. Kadao, can you reccommend any websites to book with?
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I checked a lot of on-line sights and ended up with cruiseplanners.com. I got the best price from them, but I also didn't accept their first quote. I let them know I was looking at other sights and they told me they would beat any other legitimate agency, and they did. I've also heard that Cruisequick.com is a good sight, but I didn't check them out at the time. Good luck - good deals are out there, sometimes you just have to work to get them.
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I forgot to mention something.
The first time I got the quote from cruiseplanners I called the toll free number of the cruise line and asked if they were familiar with cruiseplanners and asked if they ever had any problems with them. They said that Cruiseplanners did a lot of business with them and so far they have not had problems with them. Whatever on-line company you chose, you might want to contact the cruise line to check, just in case.
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text: Access and Athonet build Malawi's first LTE wireless network 14 Apr 2015 04:09 PM Athonet's PriMo LTE Virtual Enhanced Packet Core offering provides cost effective and easily deployed mobile infrastructureMobile operator Access Communications and Italian mobile infrastructure firm Athonet have deployed the first 4G LTE network in Malawi. Access approached Athonet with the challenge to implement an LTE network, the first in the country, in a matter of weeks to enable Access to launch its latest generation broadband wireless service.The network had to be scalable nationwide, very cost-efficient, IT-friendly and simple to integrate with Access' existing infrastructure, including its CDMA network. Leveraging its future-proof PriMo LTE Virtual Enhanced Packet Core (EPC), Athonet successfully delivered the complete mobile infrastructure, which has enabled Access to provide the first LTE service in Malawi in record time.Leveraging Athonet's technology, an LTE ultra-broadband network has been implemented covering Blantyre's business district, ensuring data, live video and voice services with very low latency. The initial service offering has been oriented towards clients that require high-speed Internet access and voice services, evolving to cover larger areas of the country and consumer needs.Such a rapid and cost-effective rollout was possible thanks to:• Athonet's distributed LTE Virtual Mobile Core Network (EPC) which runs on standard IT servers or in the cloud and provides guaranteed very low latency, highly reliable ultra-broadband service in a cost-effective manner using a fully virtualised software approach• Access' longstanding experience in rolling out mobile and IP networks and serving Internet-hungry mobile customers in a cost-effective manner • Athonet's experience in integrating complete end-to-end networks. "Provision of cost effective scalable data and voice services by the telecommunications sector is directly linked to increased GDP," said Faizal Okhai, chief executive officer at Access. "We feel that the introduction of 4G LTE services in Malawi will serve a latent demand for high quality ultra-broadband Internet for corporate and individual consumers.""Internet can be a fundamental driver for growth in Africa and we are proud to be Access' partner in making ultra-broadband Internet accessible to businesses and consumers in Malawi," said Massimiliano Gianesin, head of operations at Athonet."Our software approach to infrastructure means that mobile networks in developing countries can be deployed very rapidly and cost-effectively, both in terms of CAPEX and OPEX, avoiding the complexity of legacy products and simplifying operations."Athonet believes that in a country with a very low rate of Internet access and where broadband is rare, such an innovative mobile broadband service represents an excellent case study which could be replicated in other countries as a remedy for digital divide complexities. James Atkinson EditorLinkedIn |Google + |Email Leave a CommentPlease write code to prove you're humanMore on... LTE GeneralMWC17: Zyxel to debut new LTE and Wi-Fi indoor gatewayHuawei, Vodafone and Qualcomm create LAA ready networkNokia demos live private LTE network over CBRS shared spectrumMore on... Critical CommunicationsFinland and Norway sign cross-border TETRA communication dealCC Europe 2017: Hytera showcasing new base station and handheld radioLatest in LTEMWC17: Zyxel to debut new LTE and Wi-Fi indoor gatewayHuawei, Vodafone and Qualcomm create LAA ready networkNokia demos live private LTE network over CBRS shared spectrum


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Thanks for helping us sort this video!
Thanks for helping us associate the correct Pornstars to this video!
Помогите нам: эти порнозвезды присутствуют в этом видео?
Pornstar Name:
WHO IS SHE? WHAT IS HER NAME? God this video is hot!!! Unexpectedly HOT!
This is a lady who knows how to be sexy and deserves someone who can appreciate it and be passionate.
I would certainly like to give her a good fucking
What hot?
i would love to put my cock in you. do you do anal? i would love to put my cock deep in your pussy and ass!
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The city of Boulder is a progressive community that cares about the environment and strives for sustainability. Residents care very much about making sure the Boulder of the future maintains all that they hold dear today. Upon visiting the websites of just about any local business, you'll find a section explaining how they strive to be green, and this commitment to the environment permeates much of the vibe in the Boulder area.
Boulder is also part of a fairly conservative state, and has a history with big energy companies and of embracing prohibition long before the rest of the country. As such, Boulder is a hotbed of political activity.
Boulder is one of the most liberal and Democratic cities in Colorado, politically speaking. Boulder's population is registered as 37% Democratic, 27% Republican, and 36% independent. The city of Boulder is often referred to as the "People's Republic of Boulder," and "25 square miles surrounded by reality."
Colorado's first ordinance prohibiting discrimination based on sexual orientation was passed in 1974 by the Boulder City Council and was later reversed. In 1975, Boulder County Clerk Clela Rorex was the second in the United States to ever grant same-sex marriage licenses, prior to state laws being passed to prevent it. And in 1987, Boulder voters reversed the 1974 vote, and the city became the first in the United States to prohibit discrimination based on sexual orientation by a direct vote of the people.
Boulder became the first city in Colorado to enact a smoking ban that included bars when it did so in 1996. There are politically active conservative and libertarian groups that coexist with the more liberal population. For example, The Promise Keepers, an evangelical organization for men, was conceived of in Boulder in 1990.
The community of Boulder is diverse in its politics and welcomes people from all walks of life. The city cares a great deal about maintaining a certain quality of life for its residents, making for an interesting place to live, go to school and visit.


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Patio Garden Furniture
Here at Zebrano Rattan we have a large selection of Patio Garden Furniture manufactured from our all weather synthetic rattan. We have had many years experience in the patio garden furniture industry both here in England and in Australia. Over those years we have sold wooden, metal, rattan and even plastic patio garden furniture. When setting up the Zebrano website we considered all of our previous patio garden furniture ranges before opting for rattan garden furniture.
The plastic patio garden furniture was not suitable for our new Zebrano site as it did not fit into our style and quality mandate. We were aiming for a high quality product that delivers on price as well as style. The plastic did not reach these levels. Next up was the teak patio garden furniture which certainly hit the desired level of quality and style. Despite the teak being very well suited for outdoor use we felt that the designs were a little old hat and the teak market was very much a traditional one. We were looking for a more contemporary range, so the teak was also abandoned.
Metal patio garden furniture had made a bit of a comeback in the style stakes and with the modern metal furniture being made from aluminum, it was also good in varied weather conditions. The aluminum furniture does not rust and the paint used can be left outside for many years without peeling or flaking off. In the end we felt that the designs were not contemporary enough for us so once again the aluminum patio garden furniture was discounted.
Finally we settled for the all weather rattan patio garden furniture which we felt hit all the right notes. Not only was the design contemporary it was also capable of being left outside all year round and better still we could offer it to the public at some fantastic rates. The all weather aspect of the rattan patio garden furniture was crucial in our decision making as it is very much in demand by the public. People don't like the idea of putting there furniture away every night and in the case of the rattan you don't even have to put it anyway in the winter. Why not have a look at our ever expanding range of rattan garden furniture.
Author David Rae


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Dylan Prunty is just 8-years-old and he's spent most of the last two years at Children's Hospital Los Angeles. He suffers from mitochondrial disease and has found that playing with Lego is the perfect distraction to the pain. From the CHLA website:
Fittingly named "Honorary LEGO Master Builder" by the LEGO Group, Dylan was invited to LEGOLAND in Carlsbad, Calif. to spend a day engulfed in his favorite hobby and pick up a LEGO kit designed especially for him, courtesy of Make-a-Wish Foundation. The kit was a 4,000 piece model of Children's Hospital Los Angeles that features specific places in the hospital that hold distinctive meaning to Dylan and also houses one of his favorite doctors, Mimi Kim, MD, assistant professor of Clinical Pediatrics at CHLA.
"I wanted to design Children's Hospital Los Angeles, because they saved my life and we live here," says Dylan. "I want to auction off the model and hope that it will make a lot of money for research at CHLA."
Dylan, who has not had any solid food in the past two years due to his digestive issues, has stayed at CHLA for as long as six months and when he is not inpatient, he makes daily visits to the outpatient towers. "He is usually in a lot of pain from kidney stones," says Dylan's mother, Kapka Prunty. "It takes three months to a year for someone to develop a kidney stone. Dylan makes them sometimes in minutes, hours, days. He can pass up to 100 kidney stones a day."
"It [LEGO Bricks] has helped distract from the pain. It's like, the best pain medicine," says Dylan.
Dylan also had his spirits lifted with a little help from Chris Pratt. The actor recently visited the hospital and put on his Star Lord costume to cheer up the kids, and took some time to recite lines from Dylan's favorite movie, The Lego Movie.
See more pictures and video of Dylan reciting lines with Pratt after the break.
(via Geekologie)


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"Tomorrow you've got HP doing their consumer electronics launch and the HP iPod launch, and next week there's the introduction of the new iMac," said Shannon Cross, an analyst at Cross Research.
Shares of Apple rose $1.73, or 5.2%, to $34.78 on the Nasdaq, where they were among the most active issues. So far this year, Apple stock has climbed 63%, compared with a 7.4% decline in the Nasdaq amid a weak overall year for technology shares.
Apple and HP, the No. 2 computer maker and largest maker of printers, earlier this year struck an agreement for HP to resell the iPod under the HP brand name, which will boost its exposure to mass consumer electronics markets.
Apple has already sold more than four million of the popular digital music players. In addition, the iPod Mini, which since its introduction has been hampered by tight supplies due to very strong demand, is now more freely available after Hitachi has boosted production of the tiny hard disk drives used in the iPod Mini.
Last month, Apple posted quarterly net income that more than tripled, fueled by surging sales of the iPod as shipments of its Macintosh computers rose 14%.
The company also then confirmed that the next-generation iMac, which will use the G5 processor manufactured by IBM, will be available in September.
The company earlier had to delay the introduction of the new iMac due to IBM's manufacturing problems with the G5 chip. Limited availability of the G5 constrained revenue and profits associated with Apple's Power Mac computers in its most recently reported, third quarter.
"Apple is in the middle of a huge product launch," Cross said. "Even if they have issues with availability of chips in the near-term due to IBM, there's remarkable demand. Obviously, at some point the chip issue is going to be resolved and you'll be left with a good amount of pent-up demand."
HP Friday is launching a wide range of consumer electronics devices, including printers, PCs, handheld PCs, and other items at a press conference in Miami hosted by Chief Executive Carly Fiorina.


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If NHL commissioner Gary Bettman wants to know why his league routinely embarrasses itself on the subject of fighting, he should parse his comments after last weekend's fiasco from the Philadelphia Flyers and Ray Emery.
"There was no rule that was violated to elevate things to the level of a suspension," Bettman told the Columbus Dispatch about Emery's assault on fellow goaltender Braden Holtby of the Washington Capitals. "It's something we'll continue to discuss.
"I don't think anybody liked it, liked what it looked like. Fortunately, it's not something that happens very often. But I'm sure it's something we'll focus on, particularly with the general managers."
The letter of the NHL's law on aggressors in fights makes it appear Emery is not subject to a fine and/or suspension from the league's director of player safety Brendan Shanahan.
But Bettman conveniently overlooked another league bylaw, 28.1, which says, in part, "the Commissioner may, at his discretion, investigate any incident that occurs in connection with any [game] and may assess additional fines and/or suspensions …"
That is just one of several NHL bylaws that give Bettman all sorts of unilateral power in all sorts of matters on and off the ice. However, too often when the commissioner or any other NHL executive says "it's something we'll continue to discuss," it really means "we'll keep tap dancing until you fools are distracted by something else and forget about it."
The state of fighting in the NHL is such that Bettman needs to show he is serious when he said it is something the league will "focus on, particularly with the general managers." And it needs to go beyond rushing in a rule change at the GMs' next meeting, Nov. 12, that makes goaltenders, like Emery, who assault unwilling combatants subject to suspensions.
It is time to make the penalties for fighting so severe it and the players who do it most – those 6-foot-8, 270-pound dancing bears – fade away.
Something else Bettman might look into, and yes, I know it's a pipe dream, is actually putting "The Code" into writing. Just for fun. After all, the mythical list of what is and isn't acceptable violence in hockey is twisted into a pretzel every day, mostly by fighting advocates trying to justify their positions. So why not eliminate any confusion by writing a few things down?
There was a time when the common wisdom was that few players were hurt in hockey fights. Two players throwing punches while standing on skates could only rarely generate enough force for a knockout punch. But that was 20 or more years ago, when even the goons were not much bigger than the other players.
Now, you have 6-foot-8, 270-pound specialists like John Scott of the Buffalo Sabres. Weight training and martial arts lessons abound, as do serious injuries. And it's more than the goons getting hurt.
Flyers forward Steve Downie challenged a Caps forward to fight in that weekend fiasco, and now he's out indefinitely with a concussion. An actual hockey player, Flyers centre Vincent Lecavalier, missed a game because of cuts sustained in the same brawl.
And for what? Well, The Code's enthusiasts say it's because when your fighter wins the whole team gets a lift. After the oft-rehearsed appearance of the dancing bears, everyone else is breathing fire. Right.
Funny thing about The Code. It used to hold that hard hits were part of the game. Isn't that what fighting advocates roar when measure are taken to protect players from head shots?
Players who wobbled back to the bench after a thunderous but clean bodycheck were told by their teammates and coaches to keep their heads up. But in the last 20 years, just about anyone who lands a good bodycheck is challenged to a fight.
What Bettman needs to do now is foster the growing feeling among some GMs that it is time to push fighting and other stupid behaviour out of the game by punishing the teams, not the individual players.
Patrick Kaleta slams someone into the boards from behind? Fine Sabres head coach Ron Rolston, GM Darcy Regier and even team owner Terry Pegula.
And make sure the fines are paid. Another of the NHL's funny customs was that management fines often went uncollected.
Make the fines steep enough to hurt, make them pay and maybe you'll see a change in culture.
Follow me on Twitter: @dshoaltsReport Typo/Error
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University Scholars Program
The application deadline for 2017-2018 University Scholars Program is Tuesday, February 7, 2017 by 4:00pm.
The University Scholars Program presents University of Florida undergraduates with the opportunity to work closely with faculty mentors while pursuing fundamental research, exploring scholarly inquiry, and developing new knowledge. University Scholars will receive a $1750 research stipend (two payments with $750 in early September 2017 and $1,000 in Spring 2018). Faculty mentors will receive $500. Scholars also have the opportunity to publish their work in UF's on-line Journal of Undergraduate Research, and will present their research in the University Scholars Symposium.
To learn more about the University Scholars Program, please attend the information session on January 18, 2017 from 3:00-3:30pm in FLG 235.
Eligibility and Nominations
Applicants must have at least one more year of undergraduate studies remaining and an overall GPA of 3.00 or better. To be eligible, you must not earn your bachelor's degree before spring 2018. For the 2017-2018 competition, the student can conduct the research during summer and fall 2017 as well as spring 2018. Selected students must register for 0-5 credit hours of Undergraduate Research during Summer A/C, fall 2017 and spring 2018. Please confer with your academic adviser and mentor to determine which research course you should register. The instructor of record for these courses will be the faculty mentor identified in the application. Students will be evaluated on their progress toward research goals and the agreement of expectations.
HHP Nominations should include:
- 2017-18 USP Application
- A resume, not to exceed two pages
- A letter of support from the faculty supervisor (mentor) including a statement noting if human and/or animal IRB training is required
- Research problem statement, rationale and significance of the study (maximum 1 page)
- Appropriate human or animal subjects protection training certificate (see below)
- Agreement of expectations: The mentor and student must determine the expectations of the University Scholar. This agreement should indicate expectations for summer and fall 2016 and spring 2017. Expectations may include number of hours, products/outcomes of this research opportunity, working with other team members, submission of conference abstract, etc. (maximum 1 page)
Submission/Nomination packets are due by Tuesday, February 7, 2017 at 4:00pm to Sarah Eberhart in FLG 200 (Dean's office suite). Questions? Email firstname.lastname@example.com.
Selection Process
A maximum of five HHP University Scholars, distributed across the Departments of Applied Physiology & Kinesiology, Health Education & Behavior and, Tourism, Recreation & Sport Management will be selected.
Awardees must attend and participate in all University Scholar Program activities that are sponsored by the Center for Undergraduate Research.
Students selected for USP must register for the appropriate number of credits hours for the Undergraduate Research course in their department. Please consult your faculty mentor for the appropriate number of credit hours (can register for 0-5 credits per term). Students must speak to a HHP academic adviser to register for the appropriate undergraduate research course.
- APK4912: APK Undergraduate Research
- HSC4912: HEB Undergraduate Research
- LEI4912: TRSM Undergraduate Research
Presentation of Research Projects
Awardees must submit a final paper and present at the University Scholars Symposium during Spring 2018.
Animal and Human Subjects Protection
Working with your mentor you will decide if you should complete the animal and/or human subjects protection training/certification program.
Protecting Human Research Participants
Animal training for IRB: IACUC training page [under first time users].
Additional information at www.scholars.ufl.edu


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foursquare just came up with a way to reward you for being loyal to a particular venue- the Century Club Badge.
Unlocking the Century Club Badge is somewhat simple. Just check-in 100 days to the same venue and you will see the following message:
That's over 100 days you've checked-in at the same place! You should have your photo hanging on the wall by now. Seriously, if they don't let you, just hang it up yourself.
Good Luck!


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Post Season Rankings: The Cornerbacks
Along with wide receiver, the cornerback position is easily the deepest and most talented in the region. We went back and forth several times trying to decide who should get the No. 1 spot as any of our top five corners were worthy of the top spot.
Full Story
January 10, 2003


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Abode Vintage Multi Drawer Side Table
The Abode Vintage Multi Drawer Side Table provides a functional as well as aesthetic touch to any space it inhabits. Made perfect for the living room or bedroom, this lovely item comes with plenty of storage.
It is made up of four drawers arranged in alternating stacks to give it a cool look. Use it for storing a variety of items. Its unique look will add some interest to your space easily.
Height: 90 cm
Width: 59 cm
Depth: 38 cm
Product information
- aandp17447
- Side tables
- 5053847013295
Finish: Left, Right
Delivery and returns
This item is sold and dispatched directly by Alexander and Pearl.
|Delivery cost
|England & Wales - standard delivery
|Scotland - standard delivery
We offer a 14 day no-quibble money-back guarantee, so if you're not delighted with your purchase you can return it for a refund. Note that bespoke and made-to-order items are excluded.
About the seller
Alexander and Pearl are online retailers of exquisite chandeliers, lighting, furniture, mirrors and decorative accessories for the home and garden. More about Alexander and Pearl...
Guaranteed and secure
- 14 day no-quibble returns *
- 100% safe and secure payments


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CHINOOKS from RAF Odiham have been in the thick of the action as British and American forces charge towards Baghdad in a bid to topple Saddam Hussein.
Twenty helicopters and about 650 crew from RAF Odiham are helping in the war on Iraq.
On Monday a spokeswoman for RAF Odiham said the Chinooks were supporting ground troops throughout the Gulf region.
"They are carrying out numerous tasks including the transportation of troops and equipment," she said.
"They are a vital element in the support of current ground operations."
Disaster struck the war effort when an RAF Tornado GR4 bomber was accidentally shot down by an American Patriot missile battery close to the Kuwaiti border as it returned from a successful sortie.
"The cause of the incident involving the GR4 is currently unknown," said the RAF Odiham spokeswoman.
"RAF aircraft are fitted with a Secure Identification Friend or Foe Transponder which is designed to identify the aircraft to incoming defences.
"This is one of many means of identifying inbound aircraft.
"No system is 100% foolproof but the UK's combat ID capability is as effective as possible and is compatible with, and comparable to, our allies'."
Five RAF Odiham-based Chinook helicopters are in the Gulf aboard HMS Ark Royal, while last week another 15 were operating in Kuwait moving British troops and equipment towards the Iraqi border.
The highly versatile helicopters will be involved in front line action and have also been helping to transport vital back-up crew such as technicians, logisticians, refullers, caterers and medics.
They have also helped transport air traffic controllers, along with engineers to build hard standings for aircraft and to carry out any repairs and replacements.
About 60 women from RAF Odiham are in the Gulf.
Most of the crew have been away from RAF Odiham for about six weeks, putting pressure on their families who are eagerly waiting for their safe return.
"There is obvious concern among the families at RAF Odiham and the thoughts of all concerned are with the families and colleagues of those injured or killed at the weekend," said the RAF Odiham spokeswoman.
"RAF Odiham has a strong welfare package in place which offers support 24 hours, seven days a week.
"The families are regularly updated with news from theatre and weekly briefings provide an opportunity to meet and discuss issues with their peers."
Officer Commanding Administration at RAF Odiham, Wing Commander Sheila Haughton, said the base also keeps families updated with newsletters giving details of forthcoming events and important contact numbers, as well as news from loved ones and an insight into life in the desert and on board ship.
The station is also busy setting up a help scheme manned by volunteers from those left behind to help with tasks such as shopping and cutting lawns.
Local schools have also been doing all they can to make life as smooth as possible as the war on Iraq rages.
About 35% of pupils at Mayhill County Junior School in The Bury, Odiham, are from RAF families.
Headteacher John Gawthorpe said as well as keeping an eye on any change in pupils' behaviour, the school has also made its computer suite available to RAF families so they can e-mail loved ones, and opened its staff room as a drop-in centre.
The Ministry of Defence has issued helpline numbers for worried families of British troops in the Gulf.
Families of RAF personnel can contact 0845 780 0900, the number for the Army is 019 8061 5500 and the Royal Navy and Royal Marines number is 0845 741 4544.


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Day 1: Arrival in Vienna. Transfer to Hotel.
Day 2: Breakfast. Guided city tour. Meeting Point: In front of the State Opera. This is an introduction to Vienna, the magnificent buildings in the city center: Imperial Palace, Opera, Museums and to Schönbrunn Palace, the Habsburg Summer Residence. Schönbrunn Palace is an outstanding example for Austrian Baroque architecture.
The summer residence of the imperial family saw important rulers: Maria Theresia who listened to young Mozart's piano concerts there, Joseph II, who said farewell to his sister Marie Antoinette, the later queen of France, Francis I who had to welcome Napoleon, etc. etc. In Schönbrunn the last Habsburg Emperor Charles I resigned and in the 1960s the American President Kennedy and Soviet leader Chrustchov met during the Vienna summit. A place of world history.
Day 3: Breakfast. In the evening tourists must be prepared for the long entertainment. Tour Viennese Serenade includes visit of amusement park Prater with riding on the world oldest Giant Ferris Wheel; dancing on Heurigenshow; dinner with wine in the world most famous wine village Grinzing and transfer back to the hotel.
Day 4: Breakfast. Our suggestion: Belevedere Palace, the former summer residence of Prince Eugene of Savoy, contains the Austrian Gallery with paintings of Austrian masters of the 19th and 20th century. The Biedermeier painters Gauermann, Schwindt, Waldmüller, Hamerling are among Europe's finest. The lust of the decadence of the Habsburg monarchy is represented by Hans Makart and the art nouveau painter Gustal Klimt and Egon Schiele lead to the expressionist art of Oskar Kokoschkla and Richard Gerstl.
In the evening we suggest: a Musical Walk (State Opera, Musikverein). There are many memorials of composers and musicians in Vienna, but the area between and around the State Opera and the Musikverein is of special interest. Attend a guided tour through the State Opera (if accessible this day) or a tour through the home of the Vienna Philharmonic Orchestra, the Musikverein.
Day 5: Breakfast. Transfer to Salzburg by train. Arrival in Salzburg. Check in to your hotel.
Day 6: Breakfast. Guided city tour. Meeting Point: in front of Mirabell Palace. It is Mozart' town, the Baroque facades and the Gothic lanes. The city tells a history from Roman to modern times through art and architecture, music and literature.
Day 7: Breakfast. Departure to airport.
Price Includes:
Also see tour packages in:
Europe Austria Local Culture Cultural Journey


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If you thought the original trailer for Lars von Trier's Antichrist was nuts, brother, you haven't seen anything!
Twitch Film nabbed the first look, which you can catch below. Antichrist tells the tale of a grieving couple who retreat to 'Eden', their isolated cabin in the woods, where they hope to repair their broken hearts and troubled marriage. But nature takes its course and things go from bad to worse.
Got news? Click here to submit it!
Do a little more than just hug a tree in the Dread Central forums!


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Mar 24, 2015 | James
Sexy doll London applications is expanding, it is possible to live a life of service adult dolls spice of life is being approached. In this exhibition, you will be able to see a display of Italian Adult dolls sexy doll London baby. The4-5 year has a 4-5 year old child's ability to learn, but also … read more


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Product Highlights
The V-Studio 20 from Cakewalk is a guitarist's dream by providing BOSS guitar effects and Roland's COSM modeling built right into powerful audio interface/effects processor, along with comprehensive recording software. The package matches the simplicity of a portable, hardware recording system with the power, flexibility, and control of modern computer-based recording.
Whether at home or on the road, you can easily connect a guitar or microphone to the VS-20 hardware and dial up genuine BOSS sounds. Once you're ready, record directly to your computer for further editing and mixing using Cakewalk Guitar Tracks recording software (Windows only). Built-in microphones allow for spontaneous recording that can capture that fleeting moment of inspiration.
The hardware interface features 8 faders and transport controls, along with inputs for optional control pedals. The microphone input can provide phantom power for use with condenser microphones. The VS-20 now has Mac editor support and control drivers for Garageband and Logic.
1 x 1/4" TS phone Guitar/Bass
1 x XLR Microphone (48V phantom powered)
2 x 1/4" TS phone Line
2 x RCA
1 x 1/4" TRS phone Headphone
|Other Connectors
2 x 1/4" TRS phone Footswitch
1 x USB
|24-bit maximum (software dependent)
|Sampling Frequencies
|Frequency Response
|20Hz to 20kHz, +0/-3.0dB
|90dBu or less
|Power Requirements
|USB bus powered
|System Requirements
Computer Requirements PC:
Intel Pentium IV 1.3GHz or AMD Athlon XP 1500 or higher
Windows XP (32-bit), Vista (32-bit), or Windows 7 (32-bit)
512MB RAM (1GB recommended)
1024 x 768, 16-bit color screen resolution
USB Port
DVD-ROM drive for installation
Netbook Requirements PC:
Intel Atom or AMD Athlon Neo Processor
Windows XP (32-bit), Vista (32-bit), or Windows 7 Home Premium (32-bit)
100MB for core program (6GB recommended)
1024 x 600, 16-bit color screen resolution
USB Port
DVD-ROM drive for installation
Software also available via download for Netbook users without DVD drives
Computer Requirements Mac:
USB Port wxqbubwfzxueubxzytxzzbzfq
Guitar Tracks 4 does not support Windows 95, 98, ME, 2000, NT, or XP x64 Professional Edition
|Dimensions (WxDxH)
|11.8 x 5.68 x 2.1" (299 x 144 x 53mm)
|1.7 lbs (0.76kg)
|Built-in microphones allow for spur of the moment recording of ideas without needing to connect instruments and microphones
|Packaging Info
|Box Dimensions (LxWxH)
|14.5 x 9.0 x 5.5"


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Submitted by dorothywithers • September 9, 2013
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- Category: Business
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