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Matthew Jelley, president of the Maritime Fun Group, stands Sunday in the middle of a major construction project to put together the "Buccaneer Bay Bullet Roller Coaster" at Shining Waters Family Fun Park in Cavendish.
©Guardian photo by Mitch MacDonald
CAVENDISH - Islanders will relive a familiar thrill with a new perspective this summer.
Construction is underway for the Buccaneer Bay Bullet roller coaster at Shining Waters Family Fun Park.
Maritime Fun Group president, Matthew Jelley, said the construction has gone well so far with the mild fall weather and that installing the new ride is the biggest initiative undertaken since the park's original construction in 2006.
"Both financially and size-wise, complexity and length of time, it's definitely the biggest project we've undertaken," said Jelley.
He said the crew will continue to do some work this week before breaking for the winter.
"We're just putting the finishing touches on the loading zone now," said Jelley.
The group will continue to calibrate the ride and get it ready for operation in the spring, with the roller coaster expected to be up and running for next summer.
For many, it will be déjà vu.
The ride, previously named the Crystal Bullet, was a staple for many years at Moncton's Crystal Palace where it was squeezed between other attractions at the indoor amusement park.
The new location has seen not only a name change, but also the user perspective of the ride.
"Because it's so visible now, it looks bigger," said Jelley. "And it's definitely a different sensation being outside versus inside."
Planning for the ride began in the summer of 2014 when the group acquired the assets of Crystal Palace following its closure on Sept. 1 that year.
The purchase of Crystal Palace's equipment was also supported by $300,000 in repayable financing from the province, which has also supported the construction of a maintenance shop.
While the logistics planning has been ongoing since 2014, construction for the roller coaster began when the park closed on Sept. 7.
The roller coaster, which is visible from Cavendish Road, has seen staff alter the park's bay area and move the ship ride over to the side.
That's also resulted in a maintenance overhaul of the Crazy Submarine ride, which was also purchased from Crystal Palace and installed at Shining Waters this past summer.
Some of the other attractions purchased from Crystal Palace have been installed at other theme parks owned by the Maritime Fun Group - Burlington Amusement Park, Cavendish's Sandspit, Moncton's Magic Mountain and an arcade at the Sunset Board Walk.


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The July 22, 2010 Edition of Superstars is a Professional wrestling television show of the WWE, it was taped at the Verizon Arena in Little Rock, Arkansas on July 20, 2010.
- Numbers in parentheses indicate the length of the match.
- (c) refers to the champion(s) heading into the match.
- Chris Masters & Montel Vontavious Porter (w/ Percy Watson) defeated The Dudebusters (Caylen Croft & Trent Barreta)
- Chavo Guerrero defeated JTG
- Primo defeated Yoshi Tatsu
- The Hart Dynasty (David Hart Smith & Tyson Kidd) (w/ Natalya) defeated The Usos (Jey Uso & Jimmy Uso) (w/ Tamina)

subset: commoncrawl


text: Neul debuts the NeulNET M2M network solution 15 Jan 2014 11:15 AM Wide area networking solution will allow service providers to launch M2M services for the Internet of Things with wide coverage, long battery life for devices and low costsNeul has unveiled its new two-way, wide-area networking solution for the Internet of Things, called NeulNET today (15 January 2014). Based on the Weightless open standard (which uses White Space spectrum), the NeulNET system is designed specifically for the Internet of Things; providing coverage, battery life, module cost and simplicity of operation, which "far out-reaches today's GPRS, 3G, CDMA and LTE WAN solutions", the company claimed.NeulNET comprises every element an operator needs to provide a scalable, secure, resilient and economical service offering, enabling them to capitalise on the huge 'Internet of Things' opportunity. This includes:NeulNET Connected Device Platform (CDP) which provides cloud-based services for managing service levels, authentication and billing together with device managementNN2510 base station for network rolloutNT1001 terminal modules incorporating Neul's Iceni RF transceiver chip.BT Plc, the largest wholesale operator in Europe, is conducting initial technical assessments of the NeulNET system. Mark Harrop, director of mobile strategy and wireless cities programme lead at BT, said: "The Internet of Things market has huge potential, but existing short-range and cellular networking technologies are unable to meet the requirements of many applications we see."A networking technology that can provide deep indoor coverage, last for many years from a single battery, is simple to use, and comes at the right price point is essential for realizing the true potential of the IoT. The NeulNET solution promises to deliver on these requirements, and we're excited to be trialling this over the coming months," said Harrop.This solution provides two-way, managed communication with QoS for M2M devices and the Internet of Things. The system is designed to operate in licensed and unlicensed spectrum and works across a variety of frequencies from global unlicensed metering bands (169 MHz or lower) up to and including sub-GHz cellular bands. NeulNET's unique ability to use different spectrum allows service providers to use unlicensed spectrum or their own licensed spectrum as they choose.Stan Boland, CEO at Neul (pictured), commented: "The Internet of Things promises a world of new services, lower operating costs and more efficient systems and products which improve quality of life. To enable this, small, super-low cost Things need to communicate with services running in the cloud, often from underground or deep within buildings, and run for many years on a single battery."Until now, network operators couldn't provide a data communications service to deliver on this promise. Our NeulNET system offers service providers a comprehensive solution, enabling them to grow their revenues by capitalising on the Internet of Things opportunity."The NeulNET Connected Device Platform is offered to network operators as a low-cost service, charged on a 'per device, per month' basis, providing and managing all the key components against service level agreements. NeulNET supports high volumes of low data Weightless devices, providing operators with a customised, agile network solution. The NeulNET Connected Device Platform enables end-users to view and configure their terminal applications, such as smart meters or environmental monitors, as if they were a private network. Simple APIs are used to get and push data out to the field.The NN2510 base station is suitable for mounting on street furniture, e.g. lamp posts or macro cell type installations. Designed for zero-touch deployment, the NN2510 base station requires only Power-over-Ethernet, IP backhaul and an antenna to provide coverage for up to a 5km cell radius.The NT1001 terminal modules incorporating Neul's Iceni RF transceiver chip, require only a battery and antenna connection. Using two AA batteries these modules will operate for 10 to 15 years and can communicate from deep within buildings and underground.Antennas have been designed for a variety of applications. Neul said the industry can expect further announcements with respect to global deployments of NeulNET technology throughout 2014.James Atkinson EditorLinkedIn |Google + |Email Leave a CommentPlease write code to prove you're humanMore on... M2MM2M Alliance gears up for 10th anniversary M2M SummitNTT DOCOMO completes tests on Cinterion LTE Cat.1 M2M modulesShipments of cellular M2M modules reached 96.0 million units in 2015More on... Smart CitiesNokia unveils wireless router for power distribution networks ETSI forms new industry group for smart city solutionsLatest in IoTAltair Semiconductor introduces narrowband CAT-M1 and NB1 chipsetTelefónica, Huawei and Kamstrup launch in NB-IoT project in Chile oneM2M standard holds third IoT interoperability event


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West Yorkshire
- +
- It took only minutes to set up.
It has a good sturdy stand, not one of the flimsy ones that rock at the slightest touch.
Connected to my PC using a HDMI cable, I needed one with a micro HDMI at one end and a standard connector at the other.
Not used the installed speaker's as I am using with headphones.
Great picture without having to go into the settings.
- −
- None so far.
Published on: 24 September 2016


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Terry Grehan Photographer
Luli BlueModel Female Northampton, England, United Kingdom
My Website: Luli Blue Burlesque artiste & ModelMy MM URL: http://www.modelmayhem.com/LuliBlue
Mayhem # 2710215
About MeI am an experienced Burlesque artiste and model.
I can do my own hair and makeup if required and have a large collection of Burlesque costumes and 1950's vintage clothing that I can bring to shoots.
I have a large hip to waist ratio and can corset down 6 inches.
*I have had the cover and photo story in Dodgem Logic Magazine Issue 2
*Appeared in The Hourglass Calendar 2010, 2012, 2013.
*Have Regular photo articles in print in Pinstriping and Kustom Graphics Magazine
I have some large tattoos: 3/4 back: peacock tail
Chest/shoulders: birds and key hole
Ankles: wings
Right Forearm: Butterflies
If you would like to work with me please do get in touch.
Have you worked with Luli Blue? Add Credits for Luli Blue! >>
Terry Grehan Photographer
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TC Morgan Photographer
Margaret s Atelier Photographer
Spencer Mitchell Photographer
James A Carey Model
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"Excellent - thank you "
"Our little dog Luie had a wonderful time with Adele - thank you so much!"
"Rory was happy and I'll be glad to have Coreena look after her again."
"Took good care of Lexa as expected :) thank you again!"
"David and Linda did a wonderful job in looking after our little boy Samson. He loved his holiday -..."
"Amanda and her family looked after our elderly toy poodle who is partially blind and did such a..."
"Great communication and very friendly :)"
"Thank you for looking after my cats:) Toby was easy to work with and we are very happy!"
"My beagle boys were so well looked after!! Steph & Danielle loved them & treated them as their own! ..."
"?????????? Melanie was awesome , we will not hesitate to have her again to look after our pets..."
"Awesome "
"Jacob has been great with Petrie. he went above and beyond to make sure Petrie is happy and has a..."


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SALISBURY, N.C. — Delhaize America last week welcomed the arrival of its newest Bottom Dollar Food store in Philadelphia while at the same time, the discount banner was vanishing from the South.
The changes speak to Delhaize's new trust in a revamped Food Lion brand to appeal to bargain shoppers in existing markets, while the company courts such customers in new territories using the Bottom
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The Barceló Pueblo Ibiza is situated 18 km from Ibiza town and from the airport, 350m from Port D'es Turrent beach and 6 km from San Antonio. The hotel is an ideal choice for families with children as it offers a wide range of facilities to ensure that the whole family is entertained throught their stay. The hotel has 349 rooms, each with a terrace, fully equipped bathroom, satellite TV, telephone, and safe. It also has handicapped accessible rooms.
The Barceló Pueblo Ibiza is situated just 350 meters from Port d'es Turrent beach, on the largest of the Pitiusas Islands, in the southwestern part of the Balearic archipelago. Ibiza Aiport is 18 kilometers away; taxis to the hotel cost approximately 25 euros.
Facilities and services at the Barcelo Pueblo Ibiza include a buffet restaurant, barbecue, 2 bars, 2 swimming-pools, playground, recreation area, solarium, sauna and jacuzzi. For the more energetic guests the hotel has a gym, a beach volleyball court, 5-a-side soccer, basketball, handball, a pelota (fronton)court, tennis, table tennis, mini golf, p�tanque, and pool tables.A full, daytime and evening entertainment program is offered.Also the hotel offers car and bicycle rental, fax, postal services, laundry services, and cots.
* Buffet breakfast
* Fitness room / Gym
* Handicapped facilities
* Laundry service
* Luggage room
* Mini-golf
* Money exchange
* Pool table
* Reception
* Sauna
* Table tennis
* Tennis court
* Terrace or solarium
* Whirlpool


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Cody is a city in Park County, Wyoming, United States. It is named after William Frederick Cody, primarily known as Buffalo Bill, from his part in the creation of the original town. The population was 9,520 at the 2010 census. It is the county seat of Park County.
External links
- Cody, Wyoming on Wikipedia


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OPERATION TERRA - Closing Thoughts
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The personal message to Lyara:
(In response to my expressed feeling that things were speeding up even more)
All right, now. You have asked and we shall answer.
Yes, it is as you have surmised. There have been some developments that we are not at all pleased with, ones that require an intensification of our efforts with those of the first two waves. This will require more of us and more of all of you, and you may pass this information on as you see fit. We will try to do as much of this increased frequency-adjusting during your sleep time, so if you can obtain more hours of sound sleep, that will make it easier for all of us -- those who are working with you and those who are receiving the work.
The "buzz" you are feeling right now is symptomatic of this further increase in acceleration. Do what you can to ground: deep breathing, meditating, quieting yourself as much as possible. Warm (not hot) baths, with sea salt for balancing or Epsom salts if a lot of clearing is taking place. Be gentle with yourself and treat yourself as if you were under a great deal of stress, for this IS stressful to your physical body, which is unaccustomed to this rapid change in frequency. It may feel as though you are going to shake yourself apart or explode from the intensity of the sound* response within your atomic structures. However, this passage -- as intense as it is -- will be of shorter duration and then you will be safely with us again and have ample time to recover and adapt.
[*The atomic structures are vibrating in frequency resonance with the sound stimulus being applied to our physical bodies.]
rising in frequency
We have to bring you up [in frequency] quickly so that you can smoothly mesh with the lowest portion of our frequency band. We are taking you up as rapidly as we can within safe limits. It will not be pleasant -- for you or for us -- but we recognize the necessity of doing this for all concerned. Too much hangs in the balance to take any unnecessary risks.
Nuclear war is now likely to occur and the effects of that are far-reaching -- and not just on the physical level. Nuclear explosions cause effects on the fabric of matter beyond the localized damage that you see -- short and long-term. They rip a hole in the fabric and are far more violent than you know. That is why we want you safely aboard the ships.
This was not anticipated 20 years ago, but a number of things have happened in unexpected ways. The special forces and third wave will -- ironically enough -- be safe on the ground, precisely because they will still be in 3D structures, [operating] at the same frequency as the planet. But those ofyou who have to transform before lifting the third wave are vulnerable to these effects if you are -- shall we say -- BETWEEN [frequency] bands. Once aboard our ships, you will be totally safe.
The order of things has changed. The lifting queue has been rearranged according to "dispensability." Those who are most central to the "op" will go first and those [who are] more peripheral will go second. It is merely a fine-tuning of what was already laid out for the first wave and the second wave. "Hospitality" functions would be secondary to communications, strategy, and quick response team training. All will be aboard before the end of the calendar year (2005) -- no vernal equinox calculation [this time].
It is time to re-evaluate your priorities also. Get your work done and take care of yourself -- counter the stress any way you can. Get sleep, nourish yourself. We will take care of the rest. You are "our own," and we take care of our own.
Amen, Adonoy Sabayoth. We are the Hosts of Heaven.
[Amen, and thank you.]
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127 Commons Circle, Saline 48176
See more homes for sale in Saline, MI
This property has been Sold!
07/18/2016 at $156,900
Stunning 3 bed 2.5 bath Ranch condo! This rare ranch condo is one of the only 3 bedroom units to come on the market! Soaring vaulted ceilings in the great room open to sunny bright breakfast nook. Or enjoy your morning coffee on the private patio. This spotless kitchen has abundant cabinet and counter space. Spacious main floor master features vaulted ceiling and walk-in closet, second bedroom also on main floor could be nice home office or craft room. Luxurious main bath and additional 1/2 bath complete the main floor. (1/2 bath was originally constructed for 1st fl laundry room). Professionally finished LL features enormous 3rd bedroom with large egress, meditation area, mini living room, walk-in closet, and full bath! Beautiful french doors open to light bright kitchenette. Additional workout space with wall mount tv. Use this space for personal enjoyment or great for in-laws/guest suite! Attached 1 car gar make this condo a must see!
Property Information
- Total Finished SqFt
- 1,901
- Lower Sq Ft
- 845
- Above Grade SqFt
- 1,056
- Garage Desc.
- Attached, Door Opener, Electric
- Water
- Public
- Sewer
- Public
- Year Built
- 2003
- Home Style
- Ranch
School Information
- School District
- Saline
- Elementary School
- Pleasant Ridge
- Middle School
- High School
- Summer Taxes
- $1,821
- Winter Taxes
- $127
- Association Fee
- $295
Rooms and Land
- MasterBedroom
- 1st Floor
- Bedroom2
- 1st Floor
- Bedroom3
- Lower Floor
- Breakfast
- 1st Floor
- GreatRoom
- 1st Floor
- Kitchen
- 1st Floor
- Basement
- Egress, Finished, Full
- Cooling
- Central
- Heating
- Forced Air, Gas
- Acreage
- 0.02
- Appliances
- Dishwasher, Disposal, Dryer, Microwave, Range/Oven, Refrigerator, Washer
- Interior Features
- 1st Floor Master, Cath/Vault Ceiling, Ceiling Fan(s)
- Exterior Materials
- Brick/Vinyl
- Exterior Features
- Cable Available, Patio, Porch
Listing Video for 127 Commons Circle, Saline MI 48176
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Listing Courtesy of Reinhart Realtors
Office Address 2452 E. Stadium Blvd
Listings last updated: . Some properties that appear for sale on this web site may subsequently have been sold and may no longer be available.
Our Michigan real estate agents can answer all of your questions about 127 Commons Circle, Saline MI 48176. Real Estate One, Max Broock Realtors, and J&J Realtors are part of the Real Estate One Family of Companies and dominate the Saline, Michigan real estate market. To sell or buy a home in Saline, Michigan, contact our real estate agents as we know the Saline, Michigan real estate market better than anyone with over 100 years of experience in Saline, Michigan real estate for sale.
The data relating to real estate for sale on this web site appears in part from the IDX programs of our Multiple Listing Services. Real Estate listings held by brokerage firms other than Real Estate One includes the name and address of the listing broker where available.
IDX information is provided exclusively for consumers personal, non-commercial use and may not be used for any purpose other than to identify prospective properties consumers may be interested in purchasing.
Provided through Ann Arbor Association Board of Realtors. © 2017 Ann Arbor Associate Board of Realtors Ltd. shareholders.


text:
The writer argues not so much with Edom as with his own people.
Edom o' Gordon—Adam of Auchindoun—did his ruthless work in 1571.
I: "Who is this that cometh from Edom, with dyed garments from Bozrah?"
These are surely the days of visitation for the pride of Edom.
This last stanza, which is not in the metre of the others, is perhaps from some copy of 'Edom o Gordon.'
The Nitzab or Prfect of Edom was allowed the barren title of king.
So the king of Israel and Jehoshaphat and the king of Edom went down to him.
But the Dukes of Edom as they are called will not enter into this compact.
Hidden away in the rocky gorges of Edom, Petra is one of the strangest and most marvelous cities of the world.
Edom means red, and Bossrah is assonant to Bsser, a vinedresser.


text:
|World Without Batman
|General Information
|Batman Gotham Adventures
|Issue Number:
|First Published:
|February 2001
|Previous Issue:
|Batman Gotham Adventures #32
|Next Issue:
|Batman Gotham Adventures #34
Batman Gotham Adventures #33: World Without Batman is issue thirty-three of the Batman Gotham Adventures comic book series.
Batman begins to doubt whether his actions really make a difference in the world, and the guest-starring Phantom Stranger appears to show him what a world without a Dark Knight would look like - and believe us, it isn't pretty! Batman sees first-hand that his quest has made the lives of his comrades much greater, as one by one they seem to follow the wrong path in the Stranger's vision!
Credits Edit
- Story: Ed Brubaker
- Pencils: Brad Rader
- Inks: John Lowe
- Letters: Tim Harkins
- Colors: Lee Loughridge


text:
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Помогите нам: эти порнозвезды присутствуют в этом видео?
Pornstar Name:
bed shakes more than the guy
shes prostitute
The guy was boring. I doubt whether she has been satisfied....
'a real pounding' I must have missed that bit, all I saw was slow and easy, and boring, the guy doesn't have a clue. If I fucked my wife like that she would kick me out of bed and use a toy instead.
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text:
Chamber of Secrets a disappointment
Chamer of Secrets was a big disappointment! All of the actors walked through their roles. There was no depth.. nothing, they seemed uninspired..bored. When I saw the first movie I was blown away by how incredible it was. What a fantastic job they did at creating a book of this nature. I was equally impressed by the young actors, unfortunately none of that was true of Chamber of Secrets. Again they omitted Peeves, and cut all of the most interesting parts from the book,and added parts that never were in the story. Lockhart whom I looked forward to, to be as intertaining as he was in the book did a complete injustice to the character. I don't blame the actors but rather the screen play writers and director. I shudder to think what they will do to my favorite book in the series "The Prisoner of Azkabon". One can only hope a new director will re-inspire the magic of the first movie. In short if you enjoyed the book, the movie will be a BIG disappointment.
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Public Notice as of March 2, 2017: The Stables at Cedars of Lebanon will be closed for the 2017 season. Visitors may bring their own horse. Horses should be unloaded near the riding stables. A current negative Coggins is required for all horses entering the park.
Disc Golf Course
Cedars of Lebanon disc golf course is one of the first courses in the State. It was designed with help from the "Father of Disc Golf," Ed Headrick, in 1977. It is an 18-hole short course landscaped through cedar woods with limestone karst topography. The throws are short but techical. The course stays busy year round and is used frequently by local disc golfers.
Eight miles of hiking trails meander through the forests and glades. Hiking trails are open year-round. Visitors frequently enjoy glimpses of fox, deer, squirrel, rabbits and turkey throughout the park. Each trail is blazed with a rectangular colored blaze-mark located on trees along the trail. Please note the color of the blaze-mark for the trail that you hike. Remember to stay on the trail for your own safety. Trail maps are available in the park office.
Cedar Glades Trail - .55 Miles Natural Surface
Cedar Forest Trail - 1.9 Miles - Natural Surface - Easy
Cedar Run Trail - 2.0 Miles - Natural Surface
Dixon Merritt Trail - 0.5 Miles - Easy
Limestone Sinks Trail - 0.5 Miles - Easy
Hidden Springs Trail - 5 Miles - Easy
The pool opens for the 2017 season on Saturday, May 27. The Olympic-sized pool is 12 feet deep with a diving board a smaller two foot wading pool for children.
Memorial Day to August 1
Monday: Closed
Tuesday - Friday & Sunday: 11:00 AM to 6:30 PM
Saturday: 11:00 AM to 8:00 PM
August 1 to Labor Day
Saturday & Sunday: 11:00 AM to 6:30 PM
$5.00 per person ages two and older.
$2.50 per person campers and cabin guests
The pool is a popular location for pool parties. For complete information, including prices and availabililty, please call the park.
Birds seen or heard in or near glades include Prairie Warbler, Yellow-breasted Chat, and Chuck-Will's-Widow, as well as other typical mid-south field and forest dwellers.
Horseback Riding
Cedars of Lebanon State Park offers 12.5 miles of marked trails for horseback riding. You can also explore hundreds of miles of forestry fire trails in the joining State Forest. A current negative Coggins is required for all horses entering the park. Horses should be unloaded near the riding stables. Please note: the riding stable at Cedars is closed indefinitely, but visitors may still bring their own horse.


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When the heart of the coldest winter months arrives, it's time for a serious jacket. Our picks for the best winter jackets and parkas below are among the warmest on the market—they are packed with down fill (or synthetic on occasion) and built to stand up to freezing temperatures and howling winds. The jackets run the gamut from casual pieces designed for around-town use to performance options built for mountaineering. Some toe the line nicely and are fully capably of handling double duty. And you don't need to spend a fortune for a good winter coat either as our selections cover the spectrum from budget to high end. For more background information, see our winter jacket comparison table and buying advice below the picks.
1. The North Face Gotham II ($299)
Category: Casual
Fill: 550-fill goose down
Weight: 3 lbs. 4 oz.
What we like: Warm, looks good, and a good value.
What we don't: Heavier and less packable than a more performance-oriented jacket.
Women's: The North Face Gotham
You certainly can spend a lot more for a winter jacket, but we love the combination of quality and value offered by the Gotham II from The North Face. This coat covers all of the important bases: it's warm, waterproof, blocks the wind, and is decently breathable for use in milder temperatures. And at around $300, it will set you back considerably less than many of the pricier options below.
What are the shortcomings of the Gotham II? It has a decidedly casual look and feel (hence the name "Gotham"), meaning that it isn't ideal for the backcountry. In addition, you won't get the same warmth for the weight or compressibility as some of the pricier jackets on the list that use 800-fill down or even higher. But these shouldn't be huge issues for around-town use, which is exactly why many people buy the Gotham II. The cherry on top: we really like the looks of the jacket (thankfully the faux fur collar is removable as that could have been a deal breaker).
See the North Face Gotham II
2. Arc'teryx Ceres SV Parka ($849)
Category: Performance/casual
Fill: 850-fill goose down
Weight: 1 lb. 15 oz.
What we like: Premium warmth and packability at a low weight.
What we don't: Expensive.
Women's: Arc'teryx Ceres SV Parka
The Ceres SV is in a different stratosphere from the Gotham II above, but for hardcore adventurers, it's one of the best options out there. With 8.4 ounces of 850-fill goose down, this is a supremely cozy winter down jacket that still weighs under 2 pounds total and packs down small. It's the warmest jacket Arc'teryx makes and that says something—the company is a favorite among guides and serious alpinists who need dependable warmth.
Interestingly, the Ceres SV is technical in design but not as technical looking as you might expect. Whereas a parka like the Feather Friends Icefall below looks as if it is indeed intended to be used while standing on belay, the Ceres has a clean look that translates decently well to everyday use (we frequently notice technical jackets from Arc'teryx on the streets of Seattle and elsewhere). And despite the high cost, Arc'teryx products are built extremely well and should last as long as anything on the market. You can save a lot by going with the Gotham II, but for a performance option with a surprisingly good casual appeal, it's hard to beat the Ceres SV.
See the Arc'teryx Ceres SV Parka
3. Patagonia Wanaka Jacket ($399)
Category: Casual
Fill: 600-fill duck down
Weight: 2 lbs. 15.9 oz.
What we like: Premium build and clean styling.
What we don't: Essentially the same warmth as the Gotham II for $100 more.
The Wanaka Jacket from Patagonia is very similar to The North Face Gotham II above: it's a cold-weather piece designed primarily for urban wear. This coat is burly, well-insulated, waterproof, and blocks wind well. It doesn't offer the range of movement of some of Patagonia's more performance-centric jackets, but it's a great option for the sustained cold spells of places like the Midwest and East Coast of the United States.
Many people make the choice between the Wanaka and Gotham II, so how do these jacket compare? The Wanaka is made with 600-fill duck down vs. 550-fill goose down on the Gotham II. And the Patagonia is $100 more expensive, although it does have the premium build and styling that the company is known for. In terms of weight, the Wanaka is slightly lighter at around 3 pounds and both jackets offer very similar levels of warmth. Because of the strong similarities, we give the nod to the Gotham based on price, but both are excellent winter coats.
See the Patagonia Wanaka Jacket
4. Canada Goose Langford Parka ($900)
Category: Casual/performance
Fill: 625-fill duck down
Weight: 3 lbs. 5 oz.
What we like: Super warm and stylish.
What we don't: Very expensive.
Women's: Canada Goose Trillium Parka
At the high end of the winter jacket spectrum is Toronto-based Canada Goose. These jackets are the real deal: they're extremely warm, well built, and downright fashionable for those that want a sleek look. Our top pick from Canada Goose is the Langford Parka, which hits a nice sweet spot between Arctic and urban use. With 625-fill duck down (it's ironic that the company uses mostly duck down and not goose) and a thick and durable Artic Tech shell, they claim that the Langford can be worn down to a freezing -15°F. This is the company's second warmest tier of jacket with the famous Expedition Parka viable down to -25°F.
Aside from the awesome warmth, craftsmanship, and looks, our biggest issue with Canada Goose is price. The Langford is a staggering $900 (the Antarctic-ready Expedition Jacket is a whopping $1,000) but Canada Goose doesn't use premium down like Arc'teryx or other high-end brands. In fact, the Langford is only a small step up from the $400 Patagonia Wanaka in down quality, although it has more fill and is noticeably warmer. But if you run cold, need the extra insulation, or appreciate the styling, Canada Goose has a valuable corner of the market.
See the Canada Goose Langford Parka
5. Feathered Friends Icefall Parka ($599)
Category: Performance
Fill: 850-fill goose down
Weight: 2 lbs. 1 oz.
What we like: Super warm: the most down fill on the list.
What we don't: The mountaineering look isn't for everyone.
Seattle-based Feathered Friends is a small company that specializes in premium down products, and they manufacture most everything in the Unites States. We love their lightweight Eos for cool weather, but the heavyweight Icefall is about as warm as it gets. Most importantly, this Parka is absolutely jammed with high-quality down: 13.8 ounces of 850-fill goose down to be exact. For comparison, the Arc'teryx Ceres SV above has 7.9 ounces of 850-fill goose down, or just over half the down for $250 more.
The reason the Icefall Parka is ranked here and not higher is its limited appeal for daily use. Yes, you could wear this jacket on the streets of Chicago or Boston in the depths of winter, but it's built for big-mountain summits and high-altitude mountaineering and looks the part. The Ceres SV has a cleaner look and wider appeal, but the Icefall Parka clearly wins on warmth and down fill.
See the Feathered Friends Icefall Parka
6. Rab Neutrino Endurance ($375)
Category: Performance/casual
Fill: 800-fill goose down
Weight: 1 lb. 6 oz.
What we like: Versatile and a good value.
What we don't: Relatively thin materials.
Women's: Rab Neutrino Endurance
At $375, there is a lot to like about the Rab Neutrino Endurance. This winter jacket has 9 ounces of 800-fill goose down (more fill weight the $849 Arc'teryx Ceres SV above with only slightly less fill power). The tall neck and burly hood do a great job at blocking wind and cold air. And we like the styling, which is performance-oriented (Rab is a climbing company) but translates better for casual use than a jacket like the Feathered Friends Icefall Parka. It's also the lightest jacket on this list at just 1 pound 6 ounces.
One shortcoming of the Endurance Neutrino is that the Pertex Endurance shell is relatively thin. While the fabric does a great job shedding snow and protecting you from the wind, the 30-denier face fabric and 20-denier lining prioritize packability and weight over all-out durability. We like the versatility that comes with a lighter weight jacket, but for casual use or if you're hard on your gear, it may be worth getting a thicker jacket like the options above.
See the Rab Neutrino Endurance
7. Marmot Fordham Jacket ($325)
Category: Casual
Fill: 700-fill duck down
Weight: 2 lbs. 11.8 oz.
What we like: Warm and stylish.
What we don't: Slim fit, particularly around the collar.
Women's: Marmot Southgate Jacket
The Marmot Fordham is another reasonably priced winter jacket designed mostly for casual use. We think it's a nice all-around option: the Fordham uses 700-fill down (higher quality than The North Face Gotham II or Patagonia Wanaka above), has a 2-layer waterproof shell, and a removable hood for when you don't need the extra protection. We also like the functional, urban look with durable fabrics and plenty of pockets.
Why isn't the Fordham ranked higher on our list? The fit is a bit snug for a cold-weather layering piece, and particularly in the collar area when trying to add extra warmth like a scarf. And some users have reported down leakage around the seams, which is commonplace with any down jacket but perhaps a little more noticeable here than normal. These issues aside, the Fordham is a very viable competitor to the casual options above.
See the Marmot Fordham Jacket
8. Patagonia DAS Parka ($299)
Category: Performance/casual
Fill: 120g PrimaLoft Silver (body), 60g PrimaLoft Gold (2nd layer around torso)
Weight: 1 lb. 7.6 oz.
What we like: Lightweight, moves well, and a good value.
What we don't: Not quite as lofty or warm as a down jacket.
The vast majority of the jackets on this list are down, which is the warmest, loftiest, and most compressible type of insulation. That doesn't mean you shouldn't at least consider a synthetic jacket, however, which will do a better job insulating when wet and save you some money in the process. All things considered, our favorite synthetic jacket for cold winter weather is the Patagonia DAS Parka, which will keep you cozy and dry while coming in at a very reasonable $299.
What do you sacrifice by going with a synthetic parka over down? The DAS Parka doesn't have the same pillowy soft feel as down, nor will it stuff into a backpack or suitcase as small. But at a relatively light 1 pound 7.6 ounces, it does a mighty good job at keeping you warm, blocking wind, and keeping moisture out. Keep in mind that with the DAS Parka you may want to layer up in frigid temperatures when standing still and not working up body heat. It's a warm jacket but has active use in mind.
See the Patagonia DAS Parka
9. Mammut Eigerjoch Jacket ($525)
Category: Performance/casual
Fill: 800-fill down
Weight: 1 lb. 11 oz.
What we like: Sleek and comfortable.
What we don't: Not as warm of other performance jackets on this list.
Swiss company Mammut is known for making technical apparel that translates very well to urban use (it has a sleeker look than brands like Patagonia and arguably even Arc'teryx). For winter use, we like the Eigerjoch Jacket, which is made with premium 800-fill down along with some fiberfill synthetic insulation on the back and underarms where moisture is most likely to build up. Throw in a water resistant 20-denier Pertex Endurance shell and you have a warm technical piece that easily can be worn in the city.
Our main concern with the Eigerjoch is the amount of warmth it provides compared to other performance jackets on the list. Mammut does not provide the fill weight, but based on the fill power and total weight compared to the Arc'teryx Ceres SV and Feathered Friends Icefall Parka above, you can bet that it's less warm than those two models. And, like the Rab Neutrino Endurance above, it's less durable than our top performance options with a 20-denier shell (the Arc'teryx uses a tougher 40-denier face fabric). Nevertheless, the Eigerjoch is more affordable than the Arc'teryx and Feathered Friends and remains a solid performance piece.
See the Mammut Eigerjoch Jacket
10. Rab Resolution Jacket ($500)
Category: Performance/casual
Fill: 800-fill down
Weight: 2 lbs. 1 oz.
What we like: Tons of premium down and a waterproof shell.
What we don't: Left zip can be frustrating.
The Resolution is the warmer and tougher sibling of the Neutrino Endurance above, with a whopping 11.6 ounces of 800-fill down. But most notably, Rab went with a Pertex Shield waterproof shell with full seam taping, giving you much better piece of mind when the conditions turn nasty. Instead of needing to carry a separate shell jacket, the Resolution is an all-in-one package that should be able to withstand the toughest of conditions.
As with all Rab gear, the zipper is on the left side and opposite of what we have come to expect here in the U.S (Rab is a based in the U.K.). This does take some getting used to, and particularly if you're always swapping out jackets and this is your only left zip, but it's not a determining factor by any means. And if anything, this jacket may provide too much warmth and weatherproofing for some people (rarely do you need full waterproofing in subfreezing temperatures). But the Resolution will do a fantastic job for those who need the warmth and protection.
See the Rab Resolution Jacket
11. Fjallraven Greenland Down Jacket ($500)
Category: Casual/performance
Fill: 500-fill down
Weight: 2 lbs. 11.8 oz.
What we like: Well built; fit allows room for layering.
What we don't: Low fill power for the price.
Similar to Canada Goose, Fjallraven makes good-looking outdoor gear that toes the line between casual and performance (at least casual levels of performance). The Greenland Down Jacket is a durable piece that offers decent warmth with its 500-fill down, tons of storage, and clean lines representative of the company's Scandinavian heritage. Like much of Fjallraven's gear, the Greenland Jacket has a G-1000 shell, which is 65% polyester and 35% cotton. G-1000 is an outlier these days but super durable and does resist moisture surprisingly well (you can add beeswax to aid in the process).
If you like Fjallraven's styling (we do), the Greenland Jacket is a fine option. We do have concerns about its warmth: 500-fill down is the lowest fill power on this list, although the jacket does have 10.6 ounces of it. And for $500, we think a number of our casual options above are better buys. Keep in mind that this coat runs large and should allow plenty of room for layering, which can be a good thing but impacts sizing.
See the Fjallraven Greenland Down Jacket
12. Mountain Hardwear Glacier Guide Down Parka ($400)
Category: Performance/casual
Fill: 650-fill down
Weight: 2 lbs. 8 oz.
What we like: Great in high winds.
What we don't: Not waterproof and lower fill power than true performance jackets.
Mountain Hardwear is perhaps best known for its ultralight Ghost Whisperer, but the Glacier Guide Down Parka is a solid option at the heavyweight end of the spectrum. With 650-fill down, good storage, and a windproof AirShield shell, this jacket is designed for frigid temperatures and serious gusts. We've seen it used on trips to the Antarctic Peninsula and that climate is no joke.
Keep in mind that Glacier Guide Down Parka is windproof but not waterproof, and the down is treated but still will soak up moisture in a big storm (this would be rare in a freezing cold climate but not impossible). The reason this jacket is ranked here and not higher is that it's difficult to categorize: it has some of the feature set of a technical jacket but lacks the premium down and lightweight/packable nature of brands like Arc'teryx, Rab, and Feathered Friends. In a crowded field, that doesn't quite cut it.
See the Mountain Hardwear Glacier Guide Down Parka
13. Outdoor Research Whitefish ($295)
Category: Casual/work
Fill: 700-fill down
Weight: 2 lbs. 2.7 oz.
What we like: Tough yet looks good.
What we don't: Not super warm and fit is a bit snug.
We've presented a number of good casual options above, but don't overlook the Whitefish from Outdoor Research. This burly winter parka uses 700-fill down, which is high for its category, has a super durable 150D polyester shell, and reinforced elbows to help avoid wear and tear. And although the Whitefish is not waterproof, it resists moisture and wind fairly well.
We like the Whitefish for casual use and winter work outside, but it's a far cry from a technical piece that you'd use in the backcountry. The jacket is warm, and particularly if you factor in its excellent wind resistance, but we suspect that's its lighter on fill that most other options on this list (OR does not provide the fill weight). It is, however, one of the toughest models around and great for those who plan on putting their jacket through the ringer.
See the Outdoor Research Whitefish
14. Caterpillar Heavy Insulated Parka ($90)
Category: Casual/work
Fill: Synthetic insulation (polyester)
Weight: 3 lbs. 8 oz.
What we like: By far the cheapest winter coat on this list.
What we don't: Heavy, stiff, and could be warmer.
Let's say you don't care about fancy high fill-power down or the latest and greatest synthetic insulation. And let's say that you just want a warm winter parka that will get that job done for as cheap as possible. If this sounds like you, give the Caterpillar's Heavy Insulated Parka a serious look. It bucks the performance and even casual trend with a work-like build (outdoor work in the winter is what many people use it for), but it's a great value for what you get at less than $100.
How is this jacket so inexpensive? The insulation and shell of the Caterpillar Insulated Parka are straight polyester—no lightweight insulation or modern waterproof fabrics here. The jacket is water resistant, and given that's you're not protecting precious down fibers from outside moisture, it does a respectable job of staying warm when wet. In addition, you get ample storage with four large front pockets and one on the sleeve. Is this jacket for climbing mountains? No way. But it's great for shoveling your walkway, everyday outdoor use, and work in cold climates.
See the Caterpillar Heavy Insulated Parka
Winter Jacket Comparison Table
|Fill Power
|Fill Weight
|The North Face Gotham II
|3 lbs. 4 oz.
|550-fill down
|Arc'teryx Ceres SV Parka
|1 lb. 15 oz.
|850-fill down
|8.4 oz.
|Patagonia Wanaka Jacket
|3 lbs.
|600-fill down
|6.2 oz.
|Canada Goose Langford Parka
|3 lbs. 5 oz.
|625-fill down
|Feathered Friends Icefall Parka
|2 lb. 1 oz.
|850-fill down
|13.8 oz.
|Rab Neutrino Endurance
|1 lb. 6 oz.
|800-fill down
|9 oz.
|Marmot Fordham Jacket
|2 lbs. 11.8 oz.
|700-fill down
|Patagonia DAS Parka
|1 lb. 7.6 oz.
Silver and Gold
120g (body) +
|Mammut Eigerjoch Jacket
|1 lb. 11 oz.
|800-fill down
|Rab Resolution Jacket
|2 lbs. 1 oz.
|800-fill down
|11.6 oz.
|Fjallraven Greenland Jacket
|2 lbs. 11.8 oz.
|500-fill down
|Mountain Hardwear Glacier Guide
|2 lbs. 8 oz.
|650-fill down
|Outdoor Research Whitefish
|2 lbs. 2.7 oz.
|700-fill down
|Caterpillar Heavy Insulated Parka
|3 lbs. 8 oz.
Winter Jacket Buying Advice
- Winter Jacket Categories: Casual vs. Performance
- Insulation Types
- Warmth
- Temperature Rating
- Layering
- Weight
- Water Resistant vs. Waterproof
- Wind Protection
- Hood
Winter Jacket Categories: Casual vs. Performance
Perhaps the single most important factor when choosing a winter jacket is its intended use. Casual winter jackets are designed for everyday wear around town—you'll see them most frequently in cold places like Denver, Chicago, Boston, New York, and even ski towns. Performance jackets, on the other hand, are more technical in nature and often lighter in weight due to the use of premium down and shell materials. These models are designed for mountaineering, climbing, and other cold-weather backcountry use.
The good news is that going with a casual coat generally saves you a good deal of money. Two of our top casual picks, The North Face Gotham II and Marmot Fordham, are around $300 yet offer ample warm and weather protection for most people. The compromises come in the weight, packability, and range of movement, which matter if you're climbing mountains but not so much for the morning commute. Toward the bottom of our picks are a couple of parkas that fall into the casual/work category with extra durable polyester shells and great toughness in general. To help clarify the best uses for each jacket, we list the category in the product specs and in our comparison table.
Insulation Types
Nearly all the jackets on this list have down fill, which is the warmest, lightest, and most compressible type of insulation. One jacket—the Patagonia DAS Parka— is made with synthetics, which is heavier and not quite as lofty but does a superior job at insulating when wet. We love both types of insulation and each has its purposes, but down wins out in pure warmth and coziness for winter. For more background on this topic, see our article on down vs. synthetic insulation.
Warmth is a function of many factors: insulation type and weight, shell fabrics, wind, layering, level of exertion, and how warm or cold you run personally. But the two most important factors in determining the warmth of your jacket are fill power and fill weight.
Fill Power
Fill power is the most heavily marketed spec among winter jackets and parkas, and refers to down specifically (nearly all the jackets on this list are down). The higher the number (600 fill, 700 fill, 800 fill, etc.), the more loft and warmth it will provide and the more easily it will compress when packing it away. Premium down also is the most expensive, which is why you'll see this number loosely correlate with price. Performance winter jackets usually are around 800 fill or higher, and casual pieces run from 500 fill to 700 fill.
Fill Weight
Fill weight is often overlooked but just as relevant as fill power. Instead of measuring the quality of the down, fill weight is simply the total weight of the down inside the jacket. For example, the Arc'teryx Ceres SV has 8.4 ounces of 850-fill down, while the Feathered Friends Icefall Parka has 13.9 ounces of 850-fill, which represents a significant difference. The calculation becomes more difficult as the fill power changes: comparing 850-fill down to 500-fill down is apples to oranges, so it's most helpful when the fill powers are at least similar.
Unfortunately fill weight isn't always provided by manufacturers, and particularly for casual pieces. We've done everything within our power to acquire that number—including spending seemingly endless periods of time on hold and explaining that fill weight is different than fill power—and include it in our comparison table when available. Around half the jackets on this list provide fill weight, which is more helpful than not.
Temperature Rating
Winter jackets don't have a uniform method of measuring warmth like the EN system for sleeping bags, but there are some good clues. As discussed above, make sure to take both fill power and fill weight into account. In addition, the shell of the jacket matters, as do the layers underneath.
By our best estimation, the majority of the jackets on this list are designed to go well below freezing for use in the heart of the winter months in cold climates like the Midwest and East Coast of the United States. Some jackets are capable of even more extreme conditions (the Canada Goose Langford Parka is given a -15°F rating by the manufacturer), while others are less insulated and designed for active use (Patagonia's DAS Parka). Of course, layer well and don't take any chances, but this article presents that warmest jackets that we cover on this site. For more lightweight and midweight jacket options, see our articles on the best down jackets and synthetic jackets.
A major contributor to warmth is the layers (or lack thereof) you wear underneath. Due to the hefty amount of insulation inside most of the jackets above, a simple baselayer will do the trick in cold weather that hasn't yet reached frigid status. Depending on the parka, when the temperature really drops (think well below freezing) you may want to add a lightweight down or synthetic jacket as a midlayer. This would be a lot of insulation, but it's an easy adjustment to make so long as you have the extra gear and the jacket has room for layering. Warmth is a lot about personal preference and the specifics of the activity and conditions, but it's always a good idea to carry an extra layer or two should you get cold or the conditions change.
The importance of weight in your winter jacket buying decision depends largely on the intended use. For those looking in the performance category (mountaineers, climbers, winter explorers, etc.), jackets with large amounts premium down will be the warmest, lightest, and most packable. Our top two picks in this category are the Arc'teryx Ceres SV (1 pound 11 ounces) and Feathered Friends Icefall Parka (2 pounds 1 ounce). For those buying at the casual end of the market, weight matters much less—you most likely won't be carrying your down jacket in a backpack and don't care as much about shaving ounces. Many casual winter jackets and parkas push the 3-pound mark and higher and won't pack down as small with lower fill-power down.
The type and thickness of the shell fabric matters in overall weight as well. Performance jackets tend to use technical fabrics that are light and thin, while casual pieces use more durable and heavier shells that add weight. On the upside, the thicker shells are much better at avoiding tears and small abrasions and therefore should last longer. Lightweight down jackets require quite a bit of care and attention.
Water Resistant vs. Waterproof
Down loses its ability to insulate when wet, and therefore all jackets on this list offer some protection against precipitation. Most jackets are water resistant or water repellant, meaning they have a tightly woven face fabric and durable water repellant (DWR) coating that will bead up and shed light moisture. If you combine that with treated or hydrophobic down (a treatment added to the down itself that reduces water absorption and helps it dry faster), you have yourself a pretty effective system even in wet and heavy snow.
The reality is that if you'll be wearing a full-on winter jacket, it's unlikely you'll require complete waterproofing. Water-resistant shells, like what you get with the Arc'teryx Ceres SV, The North Face Gotham II, and Rab Neutrino Endurance, offer plenty of protection in freezing, snowy conditions. Even the expedition-ready Feathered Friends Icefall isn't fully waterproof (the shell material is waterproof but the seams are not taped) because snow and ice won't penetrate the fabric like rain. If you do need complete waterproofing, however, there are some options on the market including the Rab Resolution above. This jacket has fully taped seams and a waterproof shell for staying dry if it happens to be 34°F and pouring rain.
Wind Protection
Exposure to wind can make an otherwise freezing winter day even worse. In terms of the wind resistance of a parka, a number of factors come into play including the type and thickness of the shell, amount and distribution of the insulation, and fabric of the liner. In particular, the shell itself matters most: on performance jackets, you'll see names like Gore Windstopper or Pertex for excellent wind resistance at low weights, and casual coats block the wind by the sheer thickness of the face fabric.
The truth is that all of these jackets do a respectable job at keeping wind and the other elements at bay. Midweight and lightweight jackets are much less substantial and you run the risk of catching a cold breeze through the jacket itself, but this list is composed of heavyweights that all should be considered highly wind resistant.
Perhaps more than any other type of jacket, the hood matters a lot with a winter coat. First, the hood almost always is going to have the same type of insulation as the rest of the jacket, so premium down in the body of the coat means excellent warmth for the weight in the hood. Second, a good cold-weather hood can be adjusted and tightened around the head snugly so that wind doesn't enter or blow the hood off your head (many technical winter jackets also have storm flaps around the collar to block out cold air). Finally, many performance-oriented jackets have helmet-compatible hoods, which are necessary for mountaineering and climbing. Helmet compatibility makes the hood larger and slightly less desirable for wearing without a helmet, but it isn't a deal breaker for us as long as the hood cinches down evenly.
For use on mild-weather days, some prefer the option to remove the hood from their winter coat altogether. Simply put, these hoods are bulky and can be annoying if they're just sitting along the back of your head. Among the 14 jackets above, 6 have removable hoods, and 5 of the 6 use a zipper along the back of the collar for removal. Because a zipper adds weight, it's a feature you'll typically find in a casual winter jacket (the Feathered Friends Icefall is one exception, although they use a button system). Whether this feature is a priority will come down to personal preference, but it could be a difference maker in the jacket you select. For example, the popular Patagonia Wanaka has a removable hood, but the equally popular Gotham II from The North Face does not.
Back to Our Top Winter Jacket Picks Back to Our Winter Jacket Comparison Table


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GJUST DDE 1/3/5/7 Sem Nov-Dec (UG&PG) Exam Date sheet 2016-17
Those students who are studying in the Guru Jambheswar University of Science and Technology (GJUST) and pursuing the under graduation and post graduation course like as BA BCA BBA B.Com B.Sc MA MBA MCA M.Tech M.Com M.Sc etc. and waiting their respective date sheet for odd semester ( I III V VII) and it will declared by the Guru Jambheswar University of Science and Technology (GJUST) soon on it's official website, so students to be informed that the university will conduct the in the month of November 2016 and dates sheet will declare before few days from the examination.
GJUST UG PG (1st 3rd 5th 7th ) Sem Exam Schedule 2016
- University name- Guru Jambheswar University of Science and Technology (GJUST)
- Exam Name- UG PG
- Category- Odd Sem (I III V VII) Exam Time Table 2016
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- Official web page- www.gjust.ac.in
Information on GJUST UG PG Odd Semester Exam Routine 2016
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Method To Know The Exam Date Sheet Of GJUST For Odd Sem 2016
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Definition of diablerie
1 : black magic : sorcery
2a : a representation in words or pictures of black magic or of dealings with the devilb : demon lore
3 : mischievous conduct or manner
diablerie was our Word of the Day on 03/05/2007. Hear the podcast!
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Examples of diablerie in a Sentence
the boy, who was once filled with diablerie, grew up to be a staid and rather dull man
since the common folk had an unshakable belief in a personal devil, a charge of diablerie was taken seriously
Did You Know?
Feeling devilish? Then you might be guilty of at least a little diablerie. Like the related and perhaps more familiar diabolical, the French diablerie originated with the Late Latin diabolus, which means "devil." Fittingly, diablerie was first applied to things related to the devil or to demons, particularly sorcery that was thought to call upon their aid; the word is also applied to representations of the demonic. Nathaniel Hawthorne's Young Goodman Brown and Sylvia Townsend Warner's Lolly Willowes contain examples of such representations in literature. Nowadays, the word often suggests a devilish quality or air in a musical performance or artistic work.
Origin and Etymology of diablerie
French, from Old French, from dïable devil, from Late Latin diabolus — more at devil
First Known Use: 1726See Words from the same year
Learn More about diablerie
Thesaurus: All synonyms and antonyms for diablerie Britannica.com: Encyclopedia article about diablerie
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Phelps Memorial Health Center
Phelps Memorial Health Center was recognized by Centers for Medicare & Medicaid Services (CMS) as one of modern hospitals which are scientifically measured and assessed to have high-quality health care services for promoting health and improving the quality of life. Phelps Memorial Health Center is located at 1215 Tibbals St Holdrege, NE 68949 and can be contacted via phone number (308) 995-2211.
Contact Info
- Monday - Friday: 8:00 AM - 5:00 PM
- Saturday - Sunday: Closed
Patient Experiences
Center for Medicare & Medicaid Services (CMS) regularly gathers feedback information from patients (and their family or friends) about their experiences with a certain hospital. In this survey, the patients shares their feelings about services they received, and whether they would recommend the hospital to someone else. This information is also very helpful to the hospital, telling where to focus such improvement efforts for better health care and services.
This hospital data was updated by using the dataset publicized on Apr 28th, 2017 by the Centers for Medicare and Medicaid Services (CMS). If you found out anything that is incorrect and want to change it, please follow this Update Data guide.
Related Providers
Nearby Hospitals
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555 North 30th St
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Hwy 77-75
Kimball Health Services
505 South Burg St
Fillmore County Hospital
P O Box 193, 1900 F Street
Columbus Community Hospital
4600 38th St
Newly Added Hospitals
Madonna Rehabilitation Specialty Hospital
2500 Bellevue Medical Center Drive, 4th Floor
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1600 South 48th St
Chi Hlth Creighton University Med Ctr-bergan Mercy
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Fremont Health Medical Center
450 East 23rd St
Chi Health Immanuel
6901 North 72nd St


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4 Min Read
NEW YORK (Billboard) - Thirty-four years after "Mandy" launched Barry Manilow's career, the crooner is still racking up achievements, thanks to his series of decade-themed covers albums.
"The Greatest Songs of the Eighties," due November 25 on Arista, is the fourth -- and likely final -- installment in an album series aimed squarely at pre-baby boomers. Their zest for all things Manilow offers such slam-dunk promo opportunities as Manilow's regular appearances on QVC, where he is the best-selling artist in the retail channel's history.
In 2006, "The Greatest Songs of the Fifties" became Manilow's first No. 1 album chart debut, followed by "Sixties" (No. 2) in 2006 and "Seventies" (No. 6) in 2007. In total, the three collections have sold more than 2 million copies in the United States, according to Nielsen SoundScan.
The new disc is led by the single "Islands in the Stream," a 1983 No. 1 pop, country and AC hit for Kenny Rogers and Dolly Parton. Manilow's version is a gleeful duet with Reba McEntire. Other selections include Chicago's "Hard to Say I'm Sorry," Cyndi Lauper's "Time After Time" and Stevie Wonder's "I Just Called to Say I Love You."
Scanning the playlist, Manilow says this was the most challenging of the four albums: "These songs are so well-known, so loved -- perfectly recorded records. With the '50s and '60s, we could play around with the arrangements. The '70s was more difficult, because those arrangements were wonderful. How can you touch 'Bridge Over Troubled Water'? 'You've Got a Friend' was perfectly written and recorded."
Manilow says he was determined to maintain the original writers' and singers' integrity, while still placing his stamp on the songs.
"It took a long time to figure out how to make them my own, to see where I could crawl inside the meaning of the lyric," he says. "I didn't want to do karaoke renditions. Make no mistake, I was intimidated, but I think I nailed them. Once the arrangements were done, it was one big smile after another."
Among the most novel efforts on "Eighties" is Rick Astley's 1988 No. 1 "Never Gonna Give You Up." "It has the catchiest little melody, with production from Stock, Aiken and Waterman. How do you compete with that?" asks Manilow, who called on producer Michael Lloyd (the "Dirty Dancing" soundtrack) for assistance. "I think it's going to stand out on the album."
To court Manilow's fans, Arista set up a busy schedule of TV appearances, including "The Tonight Show With Jay Leno," "Today," Rosie O'Donnell's Thanksgiving Eve special and a week's worth of coverage on "Entertainment Tonight" and "The Insider." Manilow will also return to QVC, performing five songs in an hour on November 20. Arista has print ads lined up and interviews in People and Ladies Home Journal, with Internet ads on female-leaning Web sites and radio links with syndicated adult-contemporary shows led by Delilah, John Tesh, Martha Stewart and Casey Kasem.
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Enhancer of zeste homologue 2 (EZH2) is the catalytic subunit of Polycomb repressive complex 2 (PRC2) and catalyses the trimethylation of histone H3 on Lys 27 (H3K27), which represses gene transcription. EZH2 enhances cancer-cell invasiveness and regulates stem cell differentiation. Here, we demonstrate that EZH2 can be phosphorylated at Thr 487 through activation of cyclin-dependent kinase 1 (CDK1). The phosphorylation of EZH2 at Thr 487 disrupted EZH2 binding with the other PRC2 components SUZ12 and EED, and thereby inhibited EZH2 methyltransferase activity, resulting in inhibition of cancer-cell invasion. In human mesenchymal stem cells, activation of CDK1 promoted mesenchymal stem cell differentiation into osteoblasts through phosphorylation of EZH2 at Thr 487. These findings define a signalling link between CDK1 and EZH2 that may have an important role in diverse biological processes, including cancer-cell invasion and osteogenic differentiation of mesenchymal stem cells.
The Polycomb group (PcG) protein EZH2 is a histone lysine methyltransferase associated with transcriptional repression. EZH2 functions in the multi-protein complex PRC2, which includes SUZ12 (suppressor of zeste 12) and EED (embryonic ectoderm development)1,2. EZH2 catalyses the addition of methyl groups to histone H3 at Lys 27 (H3K27) in target gene promoters, leading to epigenetic silencing. EZH2 has an important role in controlling biological processes including X-chromosome inactivation, germline development, stem cell pluripotency and cancer metastasis3.
EZH2 is aberrantly overexpressed in aggressive solid tumours and overexpression of EZH2 has been implicated in cancer progression and metastases4–7. In addition, EZH2 knockdown leads to decreased proliferation of cancer cells and a delay in the G2/M transition of the cell cycle8. As EZH2 has a role in the G2/M transition and CDK1 is one of the major G2/M kinases, and because both have a central function in controlling self-renewal and lineage specification of stem cells9, we investigated whether EZH2 is regulated by CDK1.
First, we investigated whether alteration of CDK1 activity affects H3K27 trimethylation. H3K27 trimethylation was increased in several cancer-cell lines after treatment with a CDK1 inhibitor, CGP74514A10, at a concentration (2 µM) that is specific to CDK1 in these lines (Fig. 1a). The activity of CDK1 was inhibited by CGP74514A, as assessed by in vitro kinase assay of CDK1 using histone H1 as a substrate (Fig. 1a, bottom). There was no change in EZH2, SUZ12 and EED protein level. In addition, H3K27 trimethylation level increased in accordance with CGP74514A in a dose- and time-dependent manner (Supplementary Information, Fig. S1a, b). Similar results were found when cells were treated with Roscovitine, a pan-CDK inhibitor (data not shown). Consistently, knockdown of endogenous CDK1 expression by two different shRNA (to exclude potential off-target effects of the shRNA), or by small interfering RNA (siRNA), enhanced H3K27 trimethylation (Fig. 1b and Supplementary Information, Fig. S1c). In addition, expression of a dominant-negative mutant CDK1 (DN-CDK1; ref. 11) also increased H3K27 trimethylation (Fig. 1c). As we had found that H3K27 trimethylation is increased with inhibition of CDK1 we next examined whether inhibition of CDK1 activity affects the expression of known EZH2-target genes. We tested gene expression of the HOXA family members using quantitative reverse transcription polymerase chain reaction (qRT–PCR). We found that expression of HOXA genes was suppressed by treatment with CGP74514A (Fig. 1d), indicating that inhibition of CDK1 affects the expression of EZH2-target genes.
As inactivation of CDK1 enhances trimethylation of H3K27, resulting in downregulation of EZH2-targeted gene expression, we next investigated whether CDK1, a serine/threonine kinase, might inhibit histone methyltransferase (HMTase) activity of EZH2 through phosphorylation of EZH2. We first examined whether CDK1 physically interacts with EZH2 by a co-immunoprecipitation experiment, which demonstrated an association between Myc-tagged EZH2 and haemmagglutinin (HA)-tagged CDK1 (Fig. 2a). We further validated the interaction using a GST pulldown assay to demonstrate that CDK1 binds to EZH2 (Fig. 2b). Importantly, this association was also detected with endogenous CDK1 and EZH2 by reciprocal immunoprecipitation, indicating that these two molecules interact in vivo (Fig. 2c).
Next, we investigated whether CDK1 is able to phosphorylate EZH2. An in vitro kinase assay demonstrated that CDK1 catalysed the phosphorylation of EZH2, but not glutathione S-transferase (GST; data not shown). Mass spectrometry analysis was used to identify which residue in EZH2 is phosphorylated. We found that Thr 487 of EZH2 was phosphorylated both in vivo (Supplementary Information, Fig. S2a), and in vitro by CDK1 (Fig. 2d). When we replaced the Thr 487 residue with alanine (EZH2T487A), CDK1 was no longer able to phosphorylate the mutant EZH2, as assessed by in vitro CDK1 kinase assay (Fig. 2e). In cell culture, inhibition of CDK1 with CGP74514A also reduced the phosphorylation of wild-type EZH2 (Fig. 2f; lanes 2 and 3) and again, the phosphorylation level of EZH2T487A mutant was virtually undetectable in an immunoblot using antibody against phosphorylated serine/threonine (Fig. 2f; lanes 4 versus 2). We also compared the phosphorylation level of wild-type EZH2 and EZH2T487A by in vivo 32P-labelling experiments. Phosphorylation of wild-type EZH2 occurred in vivo, but was inhibited by expression of CDK1 shRNA (Fig. 2g). The phosphorylation level of EZH2T487A was much lower than that of wild-type EZH2 and was not altered by expression of CDK1 shRNA (Fig. 2g). These results suggested that Thr 487 is a major phosphorylation site of EZH2 in vivo and can be activated by CDK1.
To confirm that CDK1 does indeed phosphorylate EZH2 at Thr 487 in vivo, we generated an antibody that specifically recognizes EZH2 phosphorylated at Thr 487, but fails to detect an unphosphorylated EZH2 peptide (Supplementary Information, Fig. S2b). To confirm the specificity of the antibody, it was incubated with wild-type Myc–EZH2 or non-phosphorylatable Myc–EZH2T487A, which were resolved on a SDS–PAGE gel and immunoblotted. The signal from the phospho-EZH2-Thr 487 antibody alone was lowered when incubated with phosphorylated peptide, but not unphosphorylated petide (Supplementary Information, Fig. S2c). Using the phospho-EZH2-Thr 487 antibody, we immunoblotted lysates from HeLa cells co-transfected with plasmids encoding CDK1 and EZH2 or EZH2T487A, which demonstrated that CDK1 stimulated the Thr 487 phosphorylation of wild-type EZH2, but not EZH2T487A (Fig. 2h). The endogenous level of phosphorylated EZH2 at Thr 487 was also increased when CDK1 was overexpressed (Fig. 2i). Activation of CDK1 by treatment of cells with Nocodazole, which arrests cells in G2/M phase, can also induce endogenous EZH2 phosphorylation at Thr 487 (Fig. 2j). Furthermore, depletion of endogenous CDK1 by transduction of cells with CDK1 shRNA reduced EZH2 phosphorylation (Fig. 2k), suggesting that endogenous CDK1 is required for EZH2 phosphorylation at Thr 487. These data indicate that EZH2 is phosphorylated at Thr 487 by CDK1 both in vitro and in vivo.
Next, we investigated whether EZH2 phosphorylation mediates the ability of CDK1 to inhibit H3K27 trimethylation. Consistently, we observed that the H3K27 trimethylation level was higher in HeLa cells transfected with plasmids encoding the mutant EZH2T487A than in cells transfected with plasmids encoding wild-type EZH2 (Fig. 3a; lanes 1 and 3). Additionally, inhibition of CDK1 with CGP74514A enhanced H3K27 trimethylation in cells transfected with plasmids encoding wild-type EZH2, but not in cells transfected with plasmids encoding EZH2T487A (Fig. 3a; lanes 1–4 of Fig. 3a are from the same gel). Together, these results suggest that phosphorylation of EZH2 at Thr 487 by CDK1 leads to a decrease in H3K27 trimethylation.
As CDK1 suppression of H3K27 trimethylation is mediated by EZH2, we investigated whether phosphorylation of EZH2 by CDK1 alters the HMTase activity of EZH2. An in vitro HMTase activity assay with oligonucleosome as the substrate showed that the EZH2T487A mutant exhibited higher HMTase activity than that of wild-type EZH2 (Fig. 3b bottom, lanes 4–6 versus lanes 1–3; Fig. 3c, lane 3 versus 1). Activation of CDK1 by co-transfection of plasmids expressing cyclin B and CDK1 inhibited HMTase activity of wild-type EZH2 (Fig. 3c; lane 2 versus 1), but not EZH2T487A (Fig. 3c; lane 4 versus 3). In addition, cells stably expressing EZH2T487A also exhibited higher H3K27 trimethylation than that of wild-type EZH2 (Fig. 3d). Together, these results suggest that phosphorylation of EZH2 at Thr 487 by CDK1 inhibits HMTase activity of EZH2.
EZH2 forms a complex with SUZ12 and EED (PRC2) in vivo1,2 and a stable complex is required for its HMTase activity. As CDK1-mediated EZH2 phosphorylation did not change the protein level of EZH2, but inhibited its HMTase activity, we next investigated whether phosphorylation might interrupt the interaction of EZH2 with SUZ12 and EED. We examined the interaction of EZH2 with SUZ12 and EED through purification of Myc-His-tagged EZH2 complex from cell lines stably expressing wild-type EZH2 and EZH2T487A. There was stronger binding between SUZ12, EED and EZH2T487A when compared with wild-type EZH2 (Fig. 3b; lanes 4–6 versus lanes 1–3 and Supplementary Information, Fig. S3a and Fig. 3c; lanes 3 versus 1). Activation of CDK1 led to the inhibition of wild-type EZH2 binding to SUZ12 and EED (Fig. 3c; lane 2 versus 1), but did not affect the binding of EZH2T487A (Fig. 3c; lane 4 versus 3). These data support the hypothesis that phosphorylation of EZH2 by CDK1 inhibits its HMTase activity through disruption of the binding between EZH2 and SUZ12 and EED.
To examine whether EZH2 phosphorylation mediated by CDK1 affects its transcriptional repressor function, we analysed expression levels of EZH2-target HOXA genes using qRT–PCR. We found that a number of genes in HOXA clusters are repressed by expression of EZH2T487A (Fig. 3e). Consistent with these results, we found that there was high EZH2 and H3K27 trimethylation on the HOXA7 and HOXA9 promoters, as detected by a quantitative chromatin immunoprecipitation (qChIP) assay (Fig. 3f). These results suggest that phosphorylation of EZH2 at Thr 487 by CDK1 promotes dissociation of PRC2 and results in inhibition of its HMTase activity, which in turn derepresses genes silenced by EZH2.
As CDK1 functions as a cell-cycle kinase during G2/M phase, and also phosphorylates EZH2, we next investigated whether CDK1-mediated phosphorylation of EZH2 was regulated during the cell cycle (Fig. 3g, h). In cells with ectopically and endogenously expressed EZH2 phosphorylation of EZH2 at Thr 487 was low in G0/G1 and S phase, but much higher in G2/M phase. This is consistent with the expression level of cyclin B1, which is known to activate CDK1 activity in G2/M phase. We found phosphorylation of EZH2 at Thr 487 occurred during the cell cycle in cells stably expressing wild-type EZH2, but not in cells expressing EZH2T487A (Supplementary Information Fig. S3b). In addition, the expression of several HOXA genes was regulated during the cell cycle, with much higher expression level in G2/M phase than in S phase, which correlated with the highest level of EZH2 phosphorylation and the lowest level of H3K27 trimethylation in G2/M phase (Fig. 3i and Supplementary Information Fig. S3b). These results suggest that CDK1 inhibits EZH2 activity and derepresses its target gene expression during cell cycle.
As EZH2 is known to enhance cell proliferation, migration and invasion4,5,6, and phosphorylation of EZH2 by CDK1 at Thr 487 inhibits EZH2 HMTase activity, we further investigated the effect of the T487A mutation on EZH2-mediated biological functions. Using stable transfectants expressing wild-type EZH2 and EZH2T487A, we did not observe significant differences in cell proliferation (data not shown). However, expression of EZH2T487A significantly enhanced cancer cell migration and invasion (Fig. 3j, k). These results suggest that phosphorylation of EZH2 at Thr 487 by CDK1 inhibits cancer cell migration and invasion.
EZH2 has an important role in regulating stem cell pluripotency and differentiation12–14. Human bone-marrow-derived mesenchymal stem cells (hMSCs) are multipotent cells15. They differentiate into chondrogenic, adipogenic or osteogenic lineages when cultured under defined in vitro conditions16–18. hMSCs differentiate into the osteogenic lineage when cultured in osteoblast differentiation medium19. However, the mechanisms governing hMSC differentiation are not well understood. Therefore, we investigated whether CDK1 regulation of EZH2 might have a role in hMSC differentiation. Treatment of hMSCs with osteoblast differentiation medium, but not adipocyte differentiation medium, resulted in sustained CDK1 activation (Fig. 4a). The activation of CDK1 was accompanied by an increase of EZH2 phosphorylation at Thr 487 and a decrease of H3K27 trimethylation (Fig. 4a). To determine whether the CDK1–EZH2 pathway is required for osteogenic differentiation, we used CDK1 shRNAs to knockdown endogenous CDK1 and measured the effects on hMSC osteogenic differentiation. Continuous incubation of hMSC with osteoblast differentiation medium for 7 days resulted in positive Alizarin Red S staining (a standard marker for osteogenic differentiation; Fig. 4b, B), as well as increased expression of osteogenic marker genes, Runx2 and osteopontin (Fig. 4c, lanes 1 and 2), whereas knockdown of CDK1 by three different shRNAs blocked osteogenic differentiation (Fig. 4b, D–F). The knockdown of CDK1 by shRNA led to decreased EZH2 phosphorylation, increased H3K27 trimethylation and repression of the osteogenic markers, Runx2 and osteopontin (Fig. 4c, lanes 3 and 4). Similar results were seen in multiple primary cultured hMSCs (Supplementary Information, Fig. S4a, b and data not shown). Together, the results suggest that the phosphorylation of EZH2 by CDK1 is critical for the osteogenic differentiation of hMSC.
Next, we investigated whether activation of CDK1 by osteogenic differentiation also led to disruption of the PRC2 complex. Indeed, the interaction of EZH2 with SUZ12 and EED was decreased when hMSCs were induced to osteodifferentiation (Fig. 4d). These results support the hypothesis that activation of CDK1 promotes osteogenic differentiation through disruption of the PRC2 complex.
Several genes have been shown to be putative targets of EZH2, such as Runx2 and TCF7, which are known to be important for osteogenesis12. To further investigate whether activation of CDK1 promotes osteogenic differentiation through disruption of the PRC2 complex, we quantified the expression of EZH2-target genes during osteogenesis by qRT–PCR. The expression of Runx2 and TCF7 mRNAs significantly increased during osteogenesis (Fig. 5a). Knockdown of CDK1 by shRNA significantly inhibited the effect of osteoblast differentiation medium on the increased expression of Runx2 and TCF7 (Fig. 5a). Consistently, a qChIP assay indicated that osteogenic differentiation resulted in decreased binding of EZH2, SUZ12 and H3K27 trimethylation at the promoter of Runx2 (Fig. 5b). These changes were reversed with knockdown of CDK1 by shRNA (Fig. 5b). These results suggest that CDK1 regulates osteogenesis through suppression of methyltransferase activity of EZH2 and promotes derepression of target genes of EZH2 such as osteogenesis-related genes Runx2 and TCF7.
To further expand our findings, we carried out genome-wide screening to identify EZH2-target genes in hMSCs before and after osteogenic differentiation. We performed ChIP using EZH2 antibody to immunoprecipitate EZH2 and its associated DNA, followed by hybridization with promoter microarrays (ChIP-on-chip). A large number of genes (> 4,000) bind to EZH2, but after osteogenic differentiation less than 30 genes bound (Supplementary Information, Tables S1 and S2), suggesting that EZH2 is disassociated from promoters of its target genes after osteogenic differentiation.
To validate the enrichment profiles of EZH2-target genes, we randomly selected nine EZH2-targeted genes that were bound by EZH2 in hMSC, but lost binding to EZH2 after osteodifferentiation, and quantified for EZH2 and H3K27me3 enrichments in an independent experiment (Supplementary Information, Table S3). In eight of the nine genes the qChIP experiments confirmed the ChIP-on-chip results, with very similar decreased binding of EZH2 (Fig. 5c) and H3K27me3 (Fig. 5d) at these gene promoters after osteogenic differentiation. Consistently, the mRNA expression of these eight genes increased significantly during osteogenesis (Fig. 5e). The data from the three genes that were scored positive, PGC, RARRES3 and FBP2, are shown in Figure 5c–e. Similar results were observed for the other five genes (Supplementary Information, Table S3, Fig. S5a, b, c).
In this study, we demonstrated a novel signal pathway in which the protein kinase CDK1 regulates the histone methyltransferase EZH2. We have found that CDK1 phosphorylates EZH2 at Thr 487 thereby disrupting EZH2 binding with SUZ12 and EED, and leading to suppression of H3K27 trimethylation and consequent derepression of target gene expression. This CDK1–EZH2 signalling pathway is important both in cell migration and invasion in cancer cells, and in the regulation of osteogenic differentiation of hMSCs through the modulation of EZH2-targeted osteogenic gene expression.
It is worthwhile to mention that while this manuscript was under revision, an interesting report was published that shows phosphorylation of EZH2 at Thr 350 by CDK1 and CDK2 is important for recruitment of EZH2 and maintenance of H3K27me3 levels at EZH2-target loci20. Blockage of Thr 350 phosphorylation not only diminishes the global effect of EZH2 on gene silencing, but also mitigates EZH2-mediated cell proliferation and migration20. The impact of EZH2 Thr 350 phosphorylation on H3K27me3 levels in target-gene promoters is not because of changes in stability, formation or intrinsic HMTase activity of PRC2 (ref. 20). In our current study, we have identified a different phosphorylation site of EZH2 by CDK1, Thr 487, which after phosphorylation not only inhibits binding of EZH2 to its targets on the promoter, but also inhibits HMTase activity of EZH2 through disruption of the PRC2 complex. We have further demonstrated that phosphorylation of EZH2 at Thr 487 by CDK1 stimulates mesenchymal stem cell osteogenic differentiation through derepression of putative EZH2-target genes. It is not clear whether a relationship exists between these two phosphorylation sites of EZH2. A systematic study may be required to further investigate the relationship between these two sites.
Methods and any associated references are available in the online version of the paper at http://www.nature.com/naturecellbiology/
We thank S. A. Miller and J. Hsu for editorial assistance. We thank A. M. Labaff for characterization of EED antibody. This work was supported by grants from National Institutes of Health (grant R01 CA109311), Kadoorie Charitable Foundations, National Breast Cancer Foundation Inc. and the M. D. Anderson Cancer Center/China Medical University and Hospital Sister Foundation Funds (to M.-C.H), NSC 96-3111-B-039 and NSC 97-3111-B-039 (to M.-C.H., L.-Y.L. and S.-P.Y), NHRI-EX98-9603BC, DOH97-TD-I-111-TM003, DOH98-TD-I-111-TM002 (to L.-Y.L.), DOH97-TD-G-111-041 (to M.-C.H.), DOH99-TD-C-111-005, NSC99-2632-B-039-001-MY3 (to L. –Y.L. and M. –C.H.). In memory of Mrs Serena Lin-Guo for her courageous battle against breast cancer.
Note: Supplementary Information is available on the Nature Cell Biology website
Author ContributionsM.-C.H., Y.W. and L.-Y.L. designed the project and wrote the paper. M.-C.H. and L.-Y.L. supervised the research. Y.W. performed most of the experiments in Figs 1–3. Y.-H.C. performed mesenchymal stem cell experiments in Figs 4 and and55 and experiments investigating the interaction between EZH2 and CDK1. C.-C.L. performed the mass spectrometry analysis. C.-Y.L. generated and characterized the phospho-EZH2 antibody. S.-P.Y. collected and characterized primary human mesenchymal stem cells. J. L., B.S., C. -C.Y. and J.-Y.Y. assisted with experiments. All authors participated in interpreting the results.
The authors declare no competing financial interests.
Reprints and permissions information is available online at http://npg.nature.com/reprintsandpermissions/
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


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Provided to YouTube by Universal Music Group International My Favorite Things · Mary J. Blige A Mary Christmas ℗ 2013 The Verve Music Group / Interscope ...
Hopalong Ginsberg - "My Favorite Things" - Instrumental synth-bagpipe cover MP3
Another day, another jazz standard. For a free MP3 download of "My Favorite Things," go to ...
Substantial - My Favorite Things (Instrumental) MP3
My Favorite Things MP3
Provided to YouTube by Warner Music Group My Favorite Things · The Brian Setzer Orchestra Dig That Crazy Christmas ℗ 2005 Surfdog, Inc. Released on: ...
My Favorite Things instrumental MP3
Hui Cox on this Coltrain-ish acoustic version of the classic song.
My Favourite Things - Sound of Music - Piano MP3
Buy the piano sheet here ...


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Calvin Klein Men's Plush Robe - Blue Shadow
This luxurious robe is the perfect way to keep toasty on chilly mornings. Designed with a wraparound silhouette in a plush cotton terry fabric, it features a classic shawl collar, over-sized patch pockets and a belted sash waist.
Available in men's sizing - see size chart for correct fit!
- Calvin Klein sleepwear
- For men
- Style: Plush Robe
- Colour: Blue Shadow
- Fit: Regular
- Plush cotton terry fabric
- Wraparound silhouette
- Shawl collar
- Over-sized patch pockets
- Belted sash waist
- Materials: 100% cotton
- Machine washable
- Our model wears a size S/M and is 189cm tall
- Country of origin: Cambodia
Calvin Klein is the epitome of casual cool. With a variety of classic styles and colours, their range of apparel, handbags, footwear, underwear, sleepwear and more is a must for any savvy shopper.


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A mouse (plural: mice) is a small mammal belonging to the order of rodents. The best known mouse species is the common house mouse (Mus musculus). It is also a popular pet. In some places, certain kinds of field mice are also common. This rodent is eaten by large birds such as hawks and eagles. They are known to invade homes for food and occasionally shelter.
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