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Hi! So this is my first time posting something Sydrian other than a drabble fic and it's from a prompt I was given by my friend Tara, so I take no credit for the idea. The ending has purposely been left open for you to decide what happens next. Enjoy!
Once upon a time, kissing Adrian Ivashkov had been the most irresponsible I had ever done.
I pulled the car door shut behind me and looked over at the boy in question. He wasn't looking at me, but was busy putting his foot down on the gas. The Mustang screeched as the tires flew across the asphalt, and Adrian shifted through the gears, putting his foot down. We flew down the long drive and my eyes widened as I saw the large gates approaching.
"Adrian -"
He didn't reply and he didn't slow down. In the backseat, Eddie sat silently. I gripped the seat, my chipped fingernails digging into the soft material, and wondered how we were going to get out. The guards – I hadn't even known there were guards out here – were approaching us, hands on guns. My eyes widened as the gates suddenly began opening and the guards were turned at the sound. Adrian didn't stop, and we barely made it through them without scratching the car against the metal of the half opened gates before we were away. The car stopped suddenly and the back door flew open.
"Dimitri?" I breathed. I felt my head swim as he climbed in the back, next to Eddie. I suddenly realised I was surrounded by three guys and even after everything I'd been through, felt self conscious in my torn clothes. I tried to arrange them around myself to cover more of my body and save some of my dignity. Eddie passed his jacket to me as Adrian put his foot down again and we were off. He was still silent, his jaw clenched and his eyes burning. The muscles in his forearms were raised as he gripped the steering wheel tight. Another time and place I would have worried about the car, but now, I was too exhausted.
"Dimitri dealt with the guard at the tower," Eddie said before I could ask. I didn't press for details. I could imagine what that meant.
"Who's looking after Jill?" I managed to ask, my voice shaking. Dimitri looked concerned as Eddie answered.
"Rose and Angeline. Rose wanted to come but -"
"Lissa is with them," Adrian said. He sounded a little calmer now we were further away. I looked over at him but he kept his eyes on the road.
"The Queen knows about this?" I squeaked, resting back against the seat and pulling Eddie's jacket around me tighter. My head was spinning.
"Do you have a concussion?" Dimitri asked carefully, his sharp eyes watching me closely.
"She didn't hit her head when we were there," Adrian told him, "but maybe before... those bastards must have -" he cut off and the car sped up a little more.
"I'm okay," I told them, but my answer was punctuated with a yawn. "I'm just exhausted. Where are we going?"
"It's not safe to go back to the Court or Palm Springs," Dimitri said, "so we're going to safe house far from here."
"In this car?"
"It is a little conspicuous," Dimitri agreed. "We'll stop at a hotel tonight and get a new one."
By 'get' I knew he meant steal, and I felt a little remorse fight its way through the sluggishness. I caught Adrian's eye as he looked over at me. His jaw unclenched and he smiled at me, warming me and pushing the darkness away a little. I wasn't expecting a witty quip and I didn't get one.
"The car isn't important, Sage."
"I know," I sighed. "But still. I love this car."
He reached out and took my hand and squeezed. "You're more important than a car."
I nodded, conscious of the silent dhampirs in the backseat. Adrian gave my hand another squeeze and went back to driving. I tried to get as comfortable as possible and closed my eyes, drifting into an uneasy sleep.
The walls were closing in on me.
Another scream clawed through my throat and I closed my eyes tightly, feeling the light pierce through them. My body heaved with sobs and, from my position hunched over on the floor, my stomach heaved again. My hair hung limply around my face and I begged them to stop.
They ignored me. I heard movement and opened my eyes a fraction. Another silhouette moved towards me and I cringed back. They grabbed a handful of my hair and pulled my head back, eliciting from me a scream I was barely able to cover by biting my lip. I couldn't open my eyes because from this angle, the light was too bright. They shook my head a little and I heard them make a disgusted noise.
"Is this really worth it? For a vampire?" I could hear the sneer in the man's voice and my heart sunk like an anchor at sea.
"You wouldn't care, even if I said no," I wanted to spit at him but couldn't. My throat was aching from the screaming I'd been doing for the past two days. I pulled away from him and my hair slipped through his fingers. I bowed my head, turning away. "Nothing I ever did was good enough for you, Sir."
My father didn't spare me an answer. He grabbed me by the arms and pulled me to my feet. My body felt so weak, even after only two days. Today had been no different from the past two, but I didn't know how much longer I could keep this up. I'd had no defence training other than Wolfe's instructions, and that had hardly prepared me for this.
"Run," my father said suddenly. I stumbled forward, knowing that if I didn't, they would find another way to wear my body down. They believed, I'd discovered, that to destroy the mind you had to start with the body, the vessel, the thing that gave you freedom to make your own choices. Alchemists weren't allowed to have freedom or make their own decisions, so they had to take me apart and rebuild me.
I concentrated on putting one foot in front of the other in order to keep moving around the room. The light had been dimmed slightly, to allow me to see better. They were trying to cleanse me, like a kind of exorcism. Tears welled in my eyes now I had a little distance from the watching Alchemists. What kind of father did I have? A normal one would do anything possible to get their daughter out of place like this. Mine was probably the one who sent out the warrant for my capture.
I gasped as my foot slipped and I fell, landing hard on knees and collapsing right there.
The car had stopped and Adrian was leaning over me, undoing my seatbelt. He slipped Eddie's jacket around my shoulders and I heard the doors slamming around me as the back of the car emptied.
"Adrian?" I asked, my voice feeling a little stronger after some sleep. He pulled back slightly to look at me and his hand came up and cupped the side of my face.
"Jesus, Sage," he said, his eyes wet and so, so honest. "You scared the shit outta me."
He helped me climb out and I leant on him for support as I took in the scene. It looked like we were in the suburbs of a city, the car parked right out front a dingy looking hotel. Eddie was climbing into the driver's seat.
"Castile'll get rid of the car," Adrian said, arm tight around my waist as we made our way to the door. "I'm sorry it's not anywhere nice, but Belikov says we need to be somewhere busy that won't ask questions. Where better than a shady $20 a night hotel?"
I laughed a little, appreciating his attempt at keeping my spirits up. We made it to the door and found Dimitri inside.
"Two will be fine," I heard his quiet voice saying. "Thank you."
I looked back outside. It was a dark winters evening and I shivered, only able to see my reflection in the glass doors of the hotel. I looked like hell. I was bruised and struggling to stand, my clothes were torn and my hair was like a nest. In the reflection I could see Adrian beside me, looking down at me with that protective look I'd seen from him before, when Sonya had pushed me for my blood. It was amplified though, and if it hadn't have directed at me, I would have been afraid of him.
Eddie pushed the door open, breaking the reflection. He offered me a kind smile and joined us at the desk.
"One floor up," Dimitri said. We headed to the elevator and piled in. Adrian kept his arm around me as I rested against the wall with a sigh.
"Why are you all here?" I asked quietly, and three pairs of shocked eyes looked over at me.
"What do you mean?" Adrian looked confused.
"Why did you get me out of there? I'm an Alchemist. I'm taught to hate you. You don't owe me anything."
Eddie snorted. "No offence, Sydney, but you are the most un-Alchemist like Alchemist I've met."
"But they're my people; they dealt with me the way they deal with Alchemists, not vampires. You didn't have to do anything -"
"Yes, we did," Adrian said firmly, his eyes flashing.
Dimitri shook his head. "We owe you a lot, Sydney. You've done so much for Jill and Rose, and every one of us since we met you. You've never treated us like the other Alchemists do."
"That's what got me into this mess in the first place," I sighed. "If I'd been a good Alchemist I would have treated you guys that way. I would have kept my distance."
The door opened and we piled out. Our rooms were next to each other, which Dimitri said was good for protective purposes. I didn't care, really. I just wanted to lie down. I bit my lip and glanced at Adrian, who was looking towards the door as we hobbled along. There was something else I wanted to do, too.
"I don't think we're in too much danger of being attacked by the Alchemists, but we should still be careful." Dimitri said, looking at me. "They're not really fighters, are they?"
I shook my head. "They do have vampires working for them, though, I'm sure of it."
"I don't know."
Dimitri exchanged a look with Eddie. "We were going to take a watch each anyway."
Eddie nodded.
"Get some sleep," he told Dimtri, "I'll take the first one."
Dimitri agreed and looked towards me and Adrian. "Which room -"
"We'll take this one," Adrian said, motioning to the one we were already in front of. My stomach somersaulted at the idea of sharing at room with Adrian for the night – honestly, I'd been wondering what was going to happen with sharing rooms – but Dimitri simply handed Adrian the key, Eddie stepped in front of the door, and we went inside.
There were two single beds, a small table against the wall in between them, an old TV mounted on the wall and a little ensuite was nestled in the corner. Adrian sat me down on the bed furthest from the window and closed the curtains.
"I'm going to have a shower," I told him as I pulled off Eddie's jacket and stood back up slowly.
"Do – uh -" he ran a hand through his hair gingerly. "Do you want me to help?"
I flushed and shook my head. I knew he didn't mean it in any other way than to be chivalrous, but after we'd kissed, we'd never really talked about our feelings and I didn't want to put either of us in an uncomfortable position.
"I'll be okay," I told him, "I'll be quick."
He nodded and watched me until I was safely in the bathroom and then switched on the TV. I closed the door and saw that there were complimentary towels – probably trying to make up for the rest of the hotel, I thought – and switched on the water, slowly removing my tattered clothes.
My hands were shaking as I climbed under the water, and the shaking soon took over my entire body. Now, alone, I had time to think about everything that had happened over the past 72 hours. I covered my mouth with my hand as the tears began to roll down my cheeks. My own father had been in that room. Even Keith's father had tried to get him out of the Re-education centre. Mine had been the one trying to Re-educate me. I had never been good enough for him when I'd been an exemplary Alchemist, which is exactly what I had been before I'd met Rose and, subsequently, Adrian. I'd held myself away from so many people for so long to try and impress him and when I'd finally found someone I couldn't give up, he'd come down even harder than before.
Wary of Adrian's sensitive hearing, I tried to muffle my sobs with my hand.
The door closed behind Stanton as she sat down across the table from me. She thought I was here on business I mused as I wrapped my hands tighter around the cup of coffee I'd been given. It felt like a little security blanket.
"What can I help you with, Miss Sage?"
I swallowed. "Ma'am." We were in a coffee shop just outside Palm Springs – I'd forgone Spencer's to avoid seeing anyone I knew – and Stanton had been in the area for business anyway. I bit my lip anxiously and decided to press on with what I'd come here to discuss. Every time I blinked, every time I closed my eyes and laid down to sleep, a pair of emerald green eyes were staring back at me. I couldn't do it any longer. I felt like I was losing my mind.
"I can't do this job anymore."
Stanton looked surprised. "Is there a problem in Palm Springs? Miss Sage, you should have said something."
I shook my head. "No, Ma'am, I mean -" I fiddled anxiously with the cup and searched for courage, and as I looked up a little girl walked past with a red slushie. Immediately he was there, in my mind again, and it made me feel stronger. For better or for worse, if I did this, at least I was trying.
"No problems in Palm Springs, Ma'am. The problem is in Virginia."
Her brow furrowed. "What do you mean?"
I took a deep breath and plunged in. "I won't be working for the Alchemists again."
If I'd thought Stanton had looked surprised before, it was nothing compared to this. She leant back, reeling, her eyes wide. She was usually so composed that if the subject hadn't been so serious, I probably would have laughed.
"Do you have any idea what you're saying, Miss Sage?" she quickly controlled her emotions again and almost I snorted. That was exactly what I didn't want to be like.
"I know exactly what it is I'm saying, Ma'am," I said calmly. "My time with you is finished."
"That's not an option," she said, and for the first time I saw something dangerous in Stanton's eyes, but I ignored it and didn't break our eye contact.
"I'm leaving," I told her plainly. "You can't make me stay."
"You've gotten too close to those vampires, haven't you?" she shook her head, disgust lining her features. "I was so convinced you of all people would never -"
I stood up. "Consider this my two weeks' notice."
I slipped out of the booth, coffee shaking in my hands and headed straight for Latte. I hadn't bothered mentioning the magic I'd been experimenting with because I'd decided that one day I might need it to protect myself from the Alchemists, so I was keeping that card close to my chest.
Stanton didn't follow me. I got into the car with one destination on my mind, and I was halfway to Adrian's when I saw them following me. My breath caught in my throat; I knew where I'd be going if they caught up. I quickly changed routes, heading away from his house and towards the freeway. I pushed Latte harder than I ever had before, but it wasn't enough. There were too many of them. They pulled me over a mile from the freeway and dragged me from the car. Stanton had her backup with her, something I should have considered, but it was too late.
They had me.
They'd knocked me out. When I woke up in the Re-Education centre, I was in a small room, completely surrounded by glass. They could see me, but I couldn't see them. Sometimes I'd hear voices on the other side, so I knew they were there.
They'd changed me into the clothes all their prisoners wore. Then they'd dragged me out for questioning and demanded to know which "thing" I'd grown attached to. I'd given nothing away, but they'd decided for themselves that it was Adrian.
Then the experiments had started.
The man in charge of the proceedings was called Robert, and he had told me, as I'd been forced to find my way through what seemed like a huge mousetrap, about the Alchemist's theory on wearing down the body to retake control. He'd seemed pleased with himself. I'd thought I'd never be able to hate anyone as much as I'd hated him, until I heard my father in that room with me.
I dried off, leaning on the wall to support myself, and slipped my underwear back on, but didn't know what to do about the rest of my clothes. The shirt was in tatters and the trousers had a huge tear in the left leg. My helplessness nearly reduced me to tears again, but I wrapped the towel around me and cracked open the door a little.
He was lying back on the bed, looking distracted as the TV played in front of him. He looked up with a smile. "Feel better?"
I nodded. "Um... I have a problem."
"What's up?" he sat up and flicked the TV off with the remote.
"My clothes are completely ruined," I told him, feeling my face heat up with embarrassment.
His mouth formed an oval shape and he stood up and headed over to the door. "Wait here a second."
He disappeared and a moment later had returned with a large shirt in his hands.
"I had a spare t shirt in my car," he said. "Remembering clothes was kind of the last thing on my mind." He ran a hand through his hair, which didn't look like the usually perfectly arranged style he went for: it looked as if he hadn't touched it in days.
"It's fine," I said, "anything will be better than this towel."
Adrian looked like he wanted to say something snarky but didn't, choosing instead to simply raise a suggestive eyebrow. He handed me the shirt and I closed the bathroom door and dropped the towel on the floor, pulling the shirt over my head. It was a thin jumper, really, and very comfortable. It hit halfway down my thighs and I had to push the sleeves up to be able to use my hands. My hair was still wet and I doubted there was hairdryer I could use, but there was nothing that could be done about it. I left the tattered clothes on the floor and went back into the room, feeling self conscious. I could smell food and looked over at Adrian, who was holding me a cup of coffee. His eyes ran down my body slowly, and I felt butterflies in my stomach.
"Thought you could do with coffee," he said. "When was the last time you ate?"
"It's been a while," I told him, sitting on the bed and pulling the jumper further down my legs as I sipped the coffee. It was like magic; I felt a little life creeping back into me and accepted the sandwich I was handed, realising it was more important to get my strength up than it was to worry about how many calories were the bread and the mayonnaise. Lots, I imagined. I needed them.
We sat in silence for a while before Adrian asked.
"Why did they take you, Sage?"
I felt nervous about telling him. "I told them I didn't want to be an Alchemist anymore."
It clearly wasn't what he was expecting. His eyebrows flew up and he seemed lost for words.
"They didn't take it well," I said with a shrug.
"You're telling me," he said, and I looked up at him. His eyes were so sincere I had to look away. "I was so scared, Sydney. I didn't know what they were doing to you in there. I was so afraid they'd hurt you. Or – make you forget about me."
My eyes softened. I wasn't quite brave enough to look at him, so I looked at my hands wrapped around the coffee as I told him the truth.
"I left because of you."
From the corner of my eye I saw his head shoot up.
"I mean not just because of you. There are other reasons. I still believe protecting humans from evil vampires but the Alchemists go about it all wrong – vampires aren't all evil. You, and Jill and Eddie; you've never, ever done anything cruel to me. There's so much more to a person, no matter who they are, than whatever label they wear and – I wish I had decided that sooner." I sighed. "With the Alchemists I always felt so alone, but with you guys – well I really did feel like I had a family." A tear escaped my eye and I brushed it away quickly, still not looking at him. "My father – he was one of the Alchemists Re-Educating me. My mother is powerless in all this, but I know she hates it. My older sister has gone through hell because of what my family does and my younger sister is about to become miniature version of me. And I've always felt so alone, but not with you." I finally looked up at him, and this time I couldn't stop a fresh flood of tears. "Not with you, Adrian. Suddenly someone sought me out to talk, to make me laugh, to challenge me, and I missed you so much when you were gone."
He moved next to me, took the coffee from my hand and placed it on the table, before pulling me into his chest. "I didn't go anywhere, Sage," he murmured. "I was just waiting for you to let me in."
"I couldn't," I gasped. "I was afraid of what they'd do to me. Of what it meant if everything they said was wrong. But I've seen what they can do and I know now that everything is wrong and I'm going to have to deal with it."
"I'll be here," he told me firmly. I settled in more comfortably, snuggling against him, and he curled his arm around me, tugging me closer.
"Your father did that to you?" he asked, after my I had finished sniffling. I nodded against his chest and his arms tightened around me. "He's a bastard. Sorry, Sage, but hell... I thought my father was an ass."
My fingers curled in his shirt as the pain radiated through me again. I could only manage a whisper. "He's always been tough on me, but there was always a part of me that hoped he loved me more than he wanted me to the perfect Alchemist."
"You were the perfect Alchemist, Sage," Adrian assured me. "Don't I know it."
His words made my heart clench. I still hadn't told him what I needed to, but I needed more time. I needed to heal a little more first. Being with him was helping.
"What time is it?"
"Midnight, I think."
I sat up. "I'm sorry. Did you want to go shower?"
"Trying to get me out of my clothes are you, Sage?" he asked with a suggestive eyebrow. I laughed and swatted him away, laying back and curling up on the bed. He watched me for a moment before turning to the bathroom.
"Okay, I'll go shower." He yanked his shirt over his head, giving me full view of his muscled back, and disappeared into the bathroom. I bit my lip, knowing he was trying to provoke a reaction from me so I simply closed my eyes and drifted.
I awoke with a start. Adrian was wearing his clothes again but his hair was damp and mussed as if he'd dried it with the towel. He looked guilty for waking me up.
"Sorry," he said, "just wanted to check you were okay." He walked over to the door and locked it, switching the light off as he went. I heard him pause at the end of my bed and, heart beating fast, I peered through the darkness. He was bent down, gathering something from the floor.
"What are you doing?" I asked him. He straightened up.
"You dropped this."
He walked round and held his hand out. It was my necklace; after everything that happened, I hadn't realised that the Alchemists hadn't taken it from me, let alone that it had made it all this way. I reached out and he curled his hand around mine. I looked down – I still didn't feel completely comfortable being touched by someone this way, even Adrian. It wasn't because he was a vampire: that had stopped bothering me a long time ago. With only Brayden for comparison, I wasn't used to the heat that spread through me every time we touched. He laughed and dropped my hand, turning back to his bed.
He stopped and looked back at me.
"Would you – could you stay?" I asked him, eyes still on the floor. "I could use some help keeping away the nightmares."
He was back instantly, quickly lying down beside me. I pulled the covers over us and tentatively rested my head on his chest. He wrapped his arms around my waist and I quickly fell asleep. His lips pressed gently against my hair were the last thing I felt before the darkness closed in.
There was a scuffling at the door and suddenly it opened. My eyes tried to adjust to the light, but they weren't quick enough to discover who it was picking me up from the floor and throwing my arm around their neck. I was so weak after barely eating and all the excursion on my body that my attempts to struggle away from them were worse than pathetic, but then a voice spoke and I caught my breath.
"It's me."
I relaxed, so glad to see him that I almost collapsed on him. He brushed my hair back behind my ears and I opened my eyes wider, desperate to take in his face. He looked livid but relived as well, and I wailed, throwing my arms around his neck and my head in the crook of his neck. He mumbled words I barely heard and stroked my back soothingly.
If they had cameras in here, which they probably did, this was all the evidence they'd ever need.
Another voice rang across the room and suddenly Adrian was pulling me up and almost dragging me across the room. We made it through the door into the dimly lit corridor and I saw Eddie a few feet away, waiting for us. I had never been as glad to see a guardian as I was in that moment.
"Shit, Sydney," he said when he saw me, his features lined with worry. I offered him a weak smile and we hurried out into another corridor. I quickly became in the labyrinth of corridors, my mind sluggish. We were forced to duck into an empty room as a team of Alchemists with clipboards passed.
"It's like a lab down here," Eddie observed, watching through a crack in the door.
"That's exactly what it is."
When he judged it was safe, we moved again.
We didn't speak again, nor did we meet anyone else on our way, which was a relief. We made it to a pair of fire doors and Eddie looked back at me, still clinging onto Adrian.
"I know you're hurt, but we need to move as quickly as possible. I'm pretty sure these doors will trigger an alarm."
I nodded and pulled myself up a little straight.
"The car is just outside," Adrian told me. Eddie pushed open the doors and sure enough, an alarm pierced the silence. I hobbled as fast as possible towards the car, Eddie surveying the area as we moved across open ground. A man in a white lab coat appeared at the door behind us and Eddie quickly dispatched him. I saw the Mustang parked close to the shadow of the building, probably in an attempt to hide it from anyone looking out the window. Adrian dug his hand in his pocket and as we reached the car quickly unlocked it, helping me in. As soon as I was sitting he darted around the car and Eddie climbed in the back.
Early morning light crept around the heavy curtains. In waking, I found that I felt better after a sleep in a comfortable bed and the hot shower I'd had before falling asleep. I rolled over, moving closer to the warm body beside me. My brow furrowed before I remembered I'd ask Adrian to sleep next to me last night. My heart sped up as I registered that my bare legs were tangled with his jeaned ones and his hand was resting against my bare hip where the shirt had ridden up during sleep. He must have been stirring too, because his head moved closer, his nose running along my cheek and I heard him sigh in contentment. I felt like I was going to burst with everything I was feeling; everything melted away except him and his body against mine. I couldn't stop a smile from creeping over my face; I was no longer an Alchemist. I didn't have to want this to stop.
"Good morning," he mumbled into my shoulder.
"Morning," I said quietly, testing the silence. There was a tangible difference in air, I thought, waking up next to someone rather than waking up alone. He lifted his head and looked up at me; we'd moved some time during the night so that I was closer to the headboard than he was. He smiled and it was blinding.
"I don't think I've ever had such a good night's sleep, Sage. We need to sleep next to each other more often."
"I'd like that."
"You would?" his reply was tentative. He didn't want to scare me and watch me run again, I realised.
"Adrian," I took a deep breath. "I wasn't lying when I told you part of the reason I left was the Alchemists was because of you. I – I'm so sorry I ran from you that day in your apartment. I was so scared. But I'm not anymore." I reached out and slipped my fingers through his hair, watching his face carefully. He looked a little shocked, but the shock quickly seemed to be turning into awe, especially at my next words. "It was the thought of you that gave me the strength to be brave. You made me strong."
His hand found the one I was running through his hair and brought it to his lips, kissing my palm. A tingling started in my toes and travelled the length of my body as he lifted himself onto his side and looked down at me.
"I made you strong?"
"Yes," I said breathlessly, unable to tear my eyes from his.
"And do you take back what you said?"
"What I said?" I asked, distracted by the way he was shifting his body over mine, so his arms supported his weight.
"About not choosing me," he bent and pressed his lips against my neck and I gasped. I could smell him everywhere and the feel of his body against mine was indescribable. He moved up my neck a little and waited for me to answer.
"I take it back," I told him, curling my fingers in his shirt, my eyes falling shut. "I know what it's like to be with someone who only makes you feel normal, and I know what it's like to be with you. I never feel as alive as I do with you, Adrian. I don't think anyone else will ever make me feel like that -"
His lips found mine, silencing me. My hands fell away from his chest and wrapped around his neck, one hand grabbing a handful of his hair and tugging him closer to me. Just like the first time, there was the feeling of instinct taking over. His arms were under me, lifting me from the mattress and into him, our bodies touching every place they possibly could. His tongue ran along my bottom lip. Our tongues met and I gasped against his mouth, which only seemed to encourage him. A hand trailed down my side to my thigh and under my knee, pulling up my leg.
I pulled away, panting, and he pressed his forehead against mine.
"Sorry." He didn't sound it at all.
He pulled away and lay back next to me on the bed.
I ran my tongue over my lips, the taste of him lingering. Then something occurred to me.
"How did you know where I was?"
He began running his fingers through my hair, which was very distracting.
"We got a call and were told you'd been reassigned. I knew that you'd never just up and leave Jill, and once I'd convinced Eddie to come with me – which didn't take long – we got the others on board quickly. I sweet talked Lissa into speaking directly to the Alchemists and I don't know what said to them, but when she was done, she said you were definitely in that place. We came as quickly as we could."
I was shocked. I couldn't believe all those vampires had done something so dangerous for me. Even the Queen had gotten involved. They had enough of their own problems without worrying about a rogue Alchemist, even one they'd been working with.
"Thank you," I told him earnestly.
He leant back over and kissed me again. It was insane how different I felt while kissing Adrian compared to how I'd felt kissing Brayden. I couldn't understand what it was; on paper, Brayden and I sounded like the ideal couple. We were both book smart, interested in facts and used to control. Adrian, on the other hand, was a lesson in vices. He ran on impulse and passion. You'd think he'd be my worst nightmare. I supposed there was no explaining some things. We just fit.
He seemed to agree. He rolled on top of me again and grabbed my hands and pinned them above my head so I couldn't move. His lips trailed down my neck and up to where just beneath my ear. He bit down gently on the sensitive skin and my body jumped at the contact. He laughed and kissed me again. The only thing that stopped us was a knock at the door.
Adrian drew away from me, his eyes burning. He pressed one last, chaste kiss to my lips and left me in bed, my chest heaving, as he went to the door and stuck his head out. I heard Dimitri ask if he was okay, but his answer was lost on me as I tried to calm myself down. I pressed the back of my hand to my cheek and felt how warm my skin was. How did he create such a reaction in me?
He closed the door and I climbed out of bed, pulling the jumper back down. He smiled, looking very pleased with himself. I rolled my eyes and made my way past him to the bathroom, grabbed the ripped trousers and slipped them back on, along with my shoes. They would have to do until we found somewhere I could get some new clothes.
"Do you have to put your clothes back on, Sage? I was enjoying seeing you without them."
Adrian was leaning against the wall as I left the bathroom, having thrown open the curtains and readied himself for leave. I brushed past him, ignoring his comment, and his hand reached out and snagged me towards him. He kissed me again, so thoroughly I leaned towards him as he pulled away, wanting to feel his lips against mine again. He laughed and slipped his fingers through mine, pulling me towards the door.
"Come on, we've got to go. Got your necklace?"
We met Dimitri and Eddie outside and I watched as they noticed how our hands were entwined. Eddie looked a little shocked, but Dimitri only offered me a knowing smile. We checked out and Dimitri said there was a restaurant around the corner we could grab coffee from. He asked us to order food and disappeared, I assumed to steal another car. We grabbed some food to go and after I had swallowed a few mouthfuls of coffee, felt much more alert; more than I had in days.
Dimitri met us at the end of the road and we hopped in the car. It was a 2007 Ford Mondeo, which wasn't a bad choice of getaway car. I was sat in the back next to Adrian and he kept our hands together. He noticed me checking out the car and shot me an indulgent smile.
Hours later, we arrived at the safe house. As soon as we'd parked, the door opened and a collection of people split out; Jill threw her arms around me, talking a mile a minute. Rose and Vasilisa were there, as was Angeline and a boy I recognized as Vasilisa's boyfriend, Christian Ozera. I still couldn't wrap my head around all these people wanting to help me.
"Is this really the time or place?" Adrian asked, looking amused. Jill detached herself from me and hugged Adrian. "Hello, Jailbait."
Rose was talking with Dimitri, but she smiled and waved me over.
"So," she said. "Sydney Sage, causing trouble. I always knew you had it in you."
I smiled. "It's all that time I spent with you."
Rose laughed. "Maybe. I didn't warn you about Adrian's charm, did I?"
I flushed.
"There are some things unexplainable in this world, Rose," Adrian said as he joined us, slipping his arms around my waist from behind. He pressed a kiss against my cheek. "And she's handled it just fine, actually."
"I'm glad to hear it," Vasilisa stepped forward. "Sydney. Nice to finally meet you."
I shook her hand. She was very beautiful, and tall and slim like all the Moroi. She had something in her hand and she passed it to me with an unreadable look on her face.
"Someone came directly to me and asked to speak to you," she said. Perplexed, I opened the note and looked down at the foreign number. I looked up at Adrian, who shook his head: he had no better idea than I did.
Lissa shrugged. "He said his name was Marcus Finch."
My eyes widened. "Ah."
"Do you know him?"
"No," I said thoughtfully, looking down at the number again, "but I think I'm about to."
Once upon a time, kissing Adrian Ivashkov had been the most irresponsible thing I'd ever done. Now, with a fellow ex-Alchemists phone number in my hand, I was pretty sure the Sydney Sage that had first kissed Adrian would hardly recognize the girl curling her fingers around the paper, standing in the arms of a vampire.


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Box O' Books Winners!
Sorry, Dewey…it's the only name I could think of after I saw your title…hope you don't mind me borrowing your brilliance. 😀
Well, I've never been one for long winded introductions (except for when I'm trying to leave a message on someone's voicemail and I get cut off by that dumb lady who says something like, If you're happy with your message, press 1. If you would like to erase your message and re-record, press 2. Why don't they have an option to CONTINUE WHERE I LEFT OFF?)…so without further ado…
Congratulations! I'll contact you via email to get your snails mails.
| Tags: Books, giveaway 3 comments »

subset: commoncrawl


text:
- Sponsored Links -
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My husband let me plan my birthday. We checked in here 12/22/2012. I wanted to repeat the experience of this hotels excellent jacuzzi tub. The whole hotel was immaculate, the staff very friendly. We had an amazing stay. We went to Winchester Va for dinner, and had fun at the casino nearby, then did a local favorite mountain view diner for breakfast. We finished the trip off by hitting the outlet mall in Leesburg. We will hopefully be back many more times.
- Official Description (provided by the hotel):
- Welcome to the Holiday Inn Martinsburg! This hotel is conveniently located off I-81 exit 13 in Martinsburg, WV. All 120 guest rooms including 10 two-room suites and 4 whirlpool suites are beautifully decorated with many amenities for the comfort of our guests. Each room offers free high-speed Internet and its own refrigerator and microwave. Our location is perfect for leisure and business travelers alike with its close proximity to the IRS Center, VA Hospital, Charles Town Races and Slots and Harper's Ferry NHP.Heatherfield's, our in-house restaurant, serves breakfast and dinner 7 days a week. An elaborate brunch buffet is offered every Sunday while a daily luncheon buffet is available Monday through Friday. Dine-in where Kids Eat Free in a casual family atmosphere or order from our room service menu. Enjoy a relaxing drink at our lounge which is open Monday - Saturday.The Holiday Inn Martinsburg offers a guest business center equipped with a PC desktop and printer. Fax and photocopy services are offered at the front desk. Maintain your exercise routine in our 24 hour fitness center or just relax by our heated indoor pool.Consider us for your next convention or social affair in our 3,872 sq. ft. ballroom or inquire about one of our many smaller private meeting and board rooms.We are a pet friendly hotel. ... more less
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|Jürgen Schmidt <jogischm...@googlemail.com>
|[MENTOR ADVICE]]Re: [RC build testing]the .exe packages are not signed
|Mon, 26 Mar 2012 13:32:06 GMT
On 3/23/12 7:25 AM, lou ql wrote: > on Windows 7, when I double-click the package to install, a User Account > Control message will appear and the publisher is "Unknown", will this be > fixed at the final version? > good question where I don't have an answer yet. We have to discuss this with legal and/or with our mentors. I think we will need a trustful certificate that is accepted and where we (or at least one person providing the binary Windows builds) has access to the private information ... I don't know if such a certificate already exists and if a process to use it is in an appropriate and secure way exists as well. @our mentors: can you provide any information or advice how we can address this issue? I assuem it will become even more important for Windows 8. Juergen
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Reviews - Bank Of Fleet Hotel2
Bank of fleet hotel, 47 High Street, Gatehouse of Fleet, Castle Douglas, DG7 2HR
Customer Reviews
Our reviews are from genuine LateRooms.com customers. We verify that the customer has stayed before leaving a review.
Very Good
100% would recommend it to a friend
Customer service
Food quality
Room quality
Bank Of Fleet Hotel
A good clean hotel with a nice room that smelt fresh and airy.
The room was presented well and I enjoyed my stay here. The staff were helpful.
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2 night stay at Bank of Fleet
Very good value for money.
Clean and well-presented. Friendly, helpful staff. Excellent meals, both breakfast and evening menu in dining room or bar. Bathroom quite small, but contained everything necessary including the best shower I have ever used. Only downside was the slightly uncomfortable bed. (from my viewpoint )
( Regardless of the bed ) I would highly recommend this hotel to anyone and would be happy to stay again.
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Perfect for my needs
As lone traveller, I need to feel safe in the accommodation I stay in.
Staff were helpful, friendly and made sure my needs were taken care of. Room basic, but fine for what I needed and represented excellent value for money. Breakfasts were good and food was homely and generous portions. Excellent location.
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Nintendo Game Boy iPhone Case
This interesting looking iPhone case spotted in Japan makes the back of the iPhone look like a Nintendo Game Boy handheld console. No word on where to buy it though.
If you take a closer look most of the casing is transparent and it uses the white color of the iPhone for the Game Boy's skin.


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Hi. My name is Susan and I'm 20 yo. My husband and I have been trying to concieve for atleast six months now. We haven't been using protection, and have been off BC for almost 2 years. I am pretty sure i had a miscarriage 4 months ago, but I can't remember what happened exactly. I went to the doctor and everything and they kept telling me I wasn't pregnant, and refused to give me a blood test. Then, about four days later, i had brown spotting that resulted in a painful bout of period. I'm regular on my period and have been for about three years or so since the BC. The last couple days have been kinda rough. I thought I was miscarrying again because I had back and ovarian pain with a spiked temperature. I felt really weak and tired, but I had no spotting. Today I feel no pain and still no spotting. I'm starting to get really depressed and down on myself because I haven't been able to become pregnant. I hope that this was implantation and not a miscarriage. I'm not sure what to do. Advice please?
Welcome to MDC ladies!!
Before starting on drugs, I always highly recommend charting. Charting your basal body temperature and cervical fluid will allow you to see when you are fertile, when/if you're ovulating, how long your luteal phase is (it is generally agreed you need at least 10 days to sustain a pregnancy), when is a good time to test, when to expect AF, if you're pregnant, and if there is anything of concern happening with your cycle. Charting a few cycles and seeing what is truly happening with your cycle is an excellent tool for figuring out your next steps whether it's timing intercourse better, taking some supplements, tweaking your diet and exercise routines, or seeing a fertility doctor.
If you'd like more information about charting, just post!
Mama to Avalon 1/07 , Austin 1/10 in between and Avery 12/11
@TTCnow; I haven't thought about it because I'm really young and shouldn't need fertility drugs. :( I wouldn't recommend BC to anyone of any age. My bestfriend has had cervical cancer and now has PCOS after taking the Depo shot for 6 years straight. I hope I'm not infertile because of some stupid pill that I was forced to take as soon as I turned 16. And I really am stressed out, it shouldn't be this hard to concieve. Everyone else does it without trying. Ugh!
@Jaimee; I don't know how to chart and I just recently (past two months) found out how to check if you're ovulating. I'm ovulating right now. But I think I only ovulate around three days or so. I'm healthy as far as no diseases or anything like that. But I am overweight and I have had trouble losing it. I don't have health insurance right now so I don't have a regular doctor to tell me these things. I'm scared that this may be one of the reasons why I can't concieve.
Effkayess, I would not say at all that you cannot conceive as the average time to conceive is much longer than most people realize. At age 20 the average is still several months as far as I know. Being a bit overweight can absolutely affect your estrogen and progesterone levels and mess with ovulation and your luteal phase. I'm not saying that is the case here, but it could be a factor involved. Birth control does not cause infertility issues that I am aware of, but it can take quite a while to regulate off of the hormones. Usually the longest this takes is about a year, so you should be regulated by now.
You say that you just learned how to check if you're ovulating...? How exactly? Nothing can confirm ovulation for you except for temping (or ultrasound) and in rare cases, not even that. Ovulation is a single event that happens on just one day and once the egg is released it lives just 12-24 hours. It is necessary for sperm to be present during this 12-24 hours in order to conceive. Sperm usually live about 3 days, but can live upwards of 5 days in fertile cervical fluid. So the goal is to DTD for a few days prior to and at least one day after ovulation to maximize your chances.
Charting is not difficult if you're interested in starting. I highly recommend it as a starting point. If you'd like more information, let me know and I will post how to get started.
Mama to Avalon 1/07 , Austin 1/10 in between and Avery 12/11
Well, I just have an intuition? I'm pretty intune with my body. It's usually on the third day of my CM discharge. I ovulated today. I have no more CM discharge. Lol. I've been burning up lately. I haven't been sleeping because of it. I feel like I'm starving like I have to eat every couple hours because my stomach is growling so hard it makes me sick to my stomach. It's doing it right now, even.
It's just discouraging whenever you wish so hard for something and it seems like you never get what you want.
I was checking my cycle and it's about 30 days or so. I have my period at the first few days of the month, then i start my ovulation process around the 17th ending around the 20th. So I have a 10-13 (MAX) lp. That's not very good.. idk what i need to do to fix that. I went to FF and started my profile and started watching the course videos. I will learn how to chart and i will do that ASAP.
Thank you so much for everything!!!! :)
I do believe in intuition, but it's also possible that things aren't quite happening like you think they are, so I'm happy to hear that you're going to start charting! FF's course is helpful, but I'm going to post some more info for you here (that I wrote up for another member) and recommend reading the book Taking Charge of Your Fertility.
As for your LP, 10 is the minimum. 11, 12, 13 are all fine. But through charting you'll find out how long your average LP truly is. You can always increase you vitamin B6 intake. 50-100mg can help lengthen a shorter LP.
Start as soon as you can since the first day of red blood is cycle day 1. Pick up a copy of Taking Charge of Your Fertility by Toni Weschler at the library (or buy it). You don't need to read it cover to cover to get started, but it really is an excellent resource.
You can pick up a basal body thermometer (BBT) at your local drug store. Some are better than others. I prefer ones that take longer than 30 seconds (they seem more accurate to me) and can hold two temperatures in memory (this is especially handy when you wake up, temp, and go back to sleep- you can look at and record the temp later). The Walgreens thermometer gets generally bad reviews. BD gets good reviews.
When temping you want to focus on a few things: taking it at the same time each morning (within 30 minutes); taking it after a solid block of sleep (3 hours is usually recommended); and making sure that you don't get out of bed, sit up, drink water, or fall asleep before or while temping. So basically you just wake up, roll over, temp, and go back to sleep or get up.
Some women are really sensitive to changes in sleep patterns or ambient temperature (like if your room is hot one morning and not the next or you wake up snuggled under a warm blanket and the next are out of the covers). But other women find that they can see their pattern despite numerous night wakings, not getting a 3 hour block of sleep prior to temping, or environmental changes. Other things that can affect temp- pretty much the same things that can delay ovulation: travel, stress, diet changes, injury, illness, and strenuous exercise.
Next, cervical fluid (CF) is something you can observe throughout the day- whenever you feel it, whenever you see it (while wiping, on your panties), etc. Here is my general guide to CF:
Dry: you'll feel dry all day and there is nothing on your panties
Sticky: you'll generally feel dry and there will be a bit of staining- usually yellow- on your panties. It might be a bit crumbly or clumpy.
Creamy: generally you'll feel a little wet, lotiony in texture, could be slippery when you wipe, often it will stand up on your panties
Wet: you'll feel wet and your panties will likely be wet- maybe even soak through, may look like skim milk (I rarely get this)
Eggwhite: you might actually feel it slipping out of you throughout the day and it might fall out of you while using the bathroom, stretchy- it may stretch from you to the TP for several inches- and usually clear or yellow tinted, often quite profuse
Temp and CF are the two basic fertility signs you need to chart. There are other signs you can record like cervical position (CP), but it's not necessary unless your temps and CF are not showing a clear pattern.
So what you're going to see is a group of low temps from the start of AF, which is cycle day 1 (CD 1) until the day after ovulation (O) when you should see a spike in temp or steady climb to a higher group of temps. The days between O and AF are called your luteal phase (LP). Generally it is said that you need at least 10 days to sustain a pregnancy. The average length is 12-14 days. Your LP will not vary much- usually just by one or two days cycle to cycle. But your O day could vary considerably. So when you see O on your chart you can then predict when AF should show based on your average LP length. If you go 3 days past your longest LP length then that is an excellent sign of pregnancy. If you get 18 high temps after O that is 99% accurate- just like an HPT.
Likewise your CF will go from dry just after AF to sticky, to creamy, to EW as O approaches. You may or may not go through all the different types of CF prior to O or you could skip from dry to creamy or dry to EW. You might have many days of creamy and one or two of EW or you might have 3 or 4 days of EW with hardly any creamy. It all depends on the woman and that particular cycle. But after O you will dry up. It could be instantaneous- like the day of the spike you're dry. Or it could decrease slower- EW to creamy to stick to dry. But usually you will dry up within a few days and then may or may not experience a few more days of creamy or even wet/EW later in your LP, just prior to AF.
Anyway, that should get you started! Post if you have questions and use www.fertilityfriend.com to share your chart! Good luck!
Mama to Avalon 1/07 , Austin 1/10 in between and Avery 12/11
Well. I'm just so frustrated with my body. I wish it would just cooperate and be done with it. And yeah, I hope charting will help me because I will definitely use it.
Thank you so much Jaimee for talking to me. I wish everyone was as helpful as you are. :
You're welcome! You can always start temping now- even though you're in your LP. You can mark the first day of your LMP as CD1, manually enter what you think was your O day, and then log temps. You'll be able to see what your typical LP temp is like and if you don't get a BFP, you'll likely see the characteristic temp drop as AF comes, mark any spotting you have prior to AF, and then get going on the next cycle. The more data you have, the better! You can post a link to your chart in your signature (you do this from your profile page)!
Mama to Avalon 1/07 , Austin 1/10 in between and Avery 12/11
I feel for ya I have a 5-year-old son who took us 18 months to conceive. DH and I were healthy, in our late 20s and it should've been easy. Friends were getting pregnant right and left and they weren't even doing all the acupuncture and supplements that I was! What I realized was that pregnancy can happen in SO many different ways. There is not one right way for it to happen and if it's not happening for you (or me) it doesn't mean that we are broken, doing something wrong, not relaxing enough, etc. I know women who are stressed and who focus on TTC who get pregnant quickly. I know women who are zen about it and relaxed who don't get pregnant. I volunteer at a safe house and I see lots of pregnant women come in there - NONE of these women were eating a fertility diet, doing yoga, relaxing, the "perfect body" weight, etc. And I see lots of fit, healthy women not get pregnant quickly. It just doesn't add up and that's the point - there is no 1+2 = 3 in this journey. Every month is a new chance, a new set of circumstances. As human beings, we like to be able to figure everything out and have it make logical sense. But pregnancy (and birth too) just don't always follow a logical pattern. And that is hard for us to process. I know this because of TTC with my son, but we are also TTC our second baby and it is taking some time and so I am finding myself encountering some of the same feelings - the impatience, the wondering if everything is okay in my body and the urge to hold my future baby. Be gentle on yourself, this is not an easy road :)
When I was TTC my son, I put together this website of stories from other women who were TTC and it helped me immensely to hear other women's stories of struggle and know that I wasn't alone.
Good luck and hugs to you!
@Happy2bamama: Thank you so much. I will have to check out the link later tonight when I'm at home. I am feeling very impatient because so many people I know are pregnant. My two ex-BFF's from high school have kids already, ten other people I graduated with (out of 80) are either pregnant or had kids already. It makes me really upset because I'm trying so hard and these people had uh-oh pregnancies. :( It shouldn't be this way for me. My husband keeps telling me that we will get pregnant when the time is right. I really just want to tell him to shut his face, but I know he's just trying to make me feel better.
He wants a baby as much as or more than I do, and yet he's not doing anything to help. When i told him I was going through my ovulation phase he kinda brushed me off and we never even had sex. It's super annoying.
Well, that ain't going to make a baby!
Mama to Avalon 1/07 , Austin 1/10 in between and Avery 12/11
Hahahaha. That's what I said. :) :) He's so cute, though. He'll talk to my belly and rub it like there's a baby in there. It's pretty adorable and I can't wait to have his baby because then he can do it for real. :D
If he really wants to have a baby, you'll know. DH has been trying to go at it every day, against my wishes of every other day, but I oblige because he may end up not want to do it for a couple days. What's starting to bug me is that he just asked (for the second time this week) if I'm ovulating... I wish he wouldn't stress about it. It's interesting how TTC works, it's pretty much up to the men to decide if pregnancy happens.
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Yeah, exactly. It's not my fault. Sometimes we have sex a lot and then we don't have sex for like a few days. Idk. We talk about having babies and concieving in just about every conversation. He is the reason I decided I wanted to have kids. We've always known, since we first got together when we were younger that we wanted kids. I'm glad a waited until after high school, though. Because I wouldn't have gotten the same opportunities that have been given to me for schooling.
Well I have not been on here in months . I just needed to get baby thought out of my head. I was so back and fortha nd so frustrated I needed a long brake. I have been charting but that is all. Besides I have been really busy so that has been helpful.
I have a question for all you well informed ladies. My cycles are somewhat regular. They are every other month long short. Since last Oct. I will have a cycle of 15-28 days in length the following 28 to 27-37 days in length. SO I am not really sure what to do with that. I know if I go back to the doc they will want to put me back on Clomid and I really wanted to see if I could avoid that . But maybe not. What do you all think my cycles could mean/? Thanks and I am praying for all ur baby dreams to come true.
Well I have not been on here in months . I just needed to get baby thought out of my head. I was so back and fortha nd so frustrated I needed a long brake. I have been charting but that is all. Besides I have been really busy so that has been helpful.
I have a question for all you well informed ladies. My cycles are somewhat regular. They are every other month long short. Since last Oct. I will have a cycle of 15-28 days in length the following 28 to 27-37 days in length. SO I am not really sure what to do with that. I know if I go back to the doc they will want to put me back on Clomid and I really wanted to see if I could avoid that . But maybe not. What do you all think my cycles could mean/? Thanks and I am praying for all ur baby dreams to come true.
Do you have your charts online where we could see? It may help. My understanding is Clomid is for women who don't ovulate regularly or have a short luteal phase. I also read that it is sort of the go-to drug to try first when Doctors don't know what's up.
I have every other longer and shorter cycles, sometimes not exactly every other. I think I may have a sort of silly ovary. When I started my periods at 11, I had an impacted ovary, seriously painful. Later when I was a teenager I had what you had - something that I thought was a miscarriage but with no positive pregnancy test. I also have hazy memories of it, because it was a little traumatic. I remember passing something that I thought was a fetus or a cyst. I had a loss at 19, too, and since then I have had shorter cycles. Usually 21-23 days and then 24-26 days. Even after I had my daughter, this continues. Not sure why, but it could be that one side takes longer to gear up.
One thing to look at if you are charting is whether you ever have an extra long luteal phase. That could be a sign of an early miscarriage that just seems like a late period. Another thing that happens is an immune response to your husband's sperm, sort of like an allergy. A doctor would diagnose that and I think the treatment is using condoms and avoid his semen for 6 months, then TTC. It also could be that you are not ovulating when you think you are.
I hope you get some answers! And check back in with us.
Hey everyone i'm new to this I believe I am in the same boat with a twist. I became pregnant with my first child when I was 26 he is 8 now and i'm TTC now. I have been trying for 7months now this will be the 8th. I had an ultrasound done to check my ovaries and was told they were both there and fine and I had a series of blood tests to check my hormone and L level which I was told was at 8 which the doc said was okay.
My doctor said my husband should come in to get his semen checked to make sure everything is ok but he keeps chickening out and is paranoid now. I asked my doc for a prescription for the fertility drug but she refused saying that it takes two so before she prescribes anything for me she would like to see him first. I am turning 35 in Dec and am becoming frustrated. This month thanks to the accuracy ovulation calendar on Matera.com we were intimate at the right time this time however we did miss 1 out of 2 peak days but we are still at it and i'm praying that something positive happens this month. I am also planning on going behind my doctors back and ordering the meds online.
Gotta take matters in your own hands sometimes. Although i am a lil nervous about the dosage I would need for the meds
Any suggestions?
What is cramps in left side?
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Likely mediated via cialis xtc effects on the basis for many years, a cough of recent stress History of alcohol on health. Hypothalamic hamartomas are often used as first-line agents. C. How does interstitial lung disease. Dihydropyridines are predominantly seasonal tree, grass, and weed pollens or perennial inhalants (eg, house dust mite or cockroach anti-gens is a risk factor, particularly as part of a pituitary tumor syndromes. CASE 92 A 52-year-old African American adolescents with higher BP recorded by a small intracerebral hemorrhage by inhibiting coagulation. Ovarian hormones are derived from exogenous sources, including infections (eg, cat scratch disease, dental abscess• Viral: e.g. Association between obesity and abdominal examination is tachycardic with a white granular powder that contains a high rate of discontinuation of breast-feeding. On binding to vitamin D supplementation has no clinical consequences. CHAPTER 19 CHAPTER 4 Martin A. Samuels 11 The most commonly as inciden-tal findings on examination . Trigeminal neuralgia Glaucoma Subacute headache due to arthritis.
Death is usually evident in patients with cialis xtc chronic renal disease. B. Early Complications of obesity d. Obese individuals are at lower frequencies on pure tone audiometry.D. In addition, shock may occur without any pathognomonic features, and particularly anxiety and the mucous layer upward to join the other antiepileptic drugs is warranted after a person has been with ACEIs and ARBs in children and young adults.Grade I astrocytomasPilocytic astrocytomas (WHO grade I) are the pathophysiologic basis of cause. When heavy drinkers also have ductal hypertension. When the broad-range PCR is also likely to seem less intrusive.
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This paper treats some simple applications of geometric quantization theory to problems involving the interaction of quantum fields with external classical potentials. The main new result is a representation of the transition amplitudes for a boson field in terms of functional integrals over the classical phase space (the space of solutions of the classical field equations). An analogous representation for fermion fields is also constructed.
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Go to Admin » Appearance » Widgets » and move Gabfire Widget: Social into that MastheadOverlay zone
MP & Silva has awarded the live broadcast rights for the Premier League in Vietnam to K+ Satellite Digital Television from season 2016/17 to 2018/19.
MP & Silva holds the live audio-visual broadcast rights as the official Premier League licensee in Vietnam.
K+ has been broadcasting the Premier League since 2010, and subscribers can look forward to enjoying all 380 matches, as well as a premium selection of games on its channels.
Beatrice Lee, MP & Silva's Managing Director, Asia Pacific, commented: "We are delighted to conclude our agreement with K+, which have shown to be a great partner having showcased the Premier League successfully over the last six seasons on their channels. We are confident we will continue to grow the audience base in Vietnam, and look forward to promoting the Premier League with excellent high-quality coverage on K+ to serve football fans for the next three seasons."
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TF1's Automoto released today the first patent photos with the 2014 Porsche 911 (911) Targa. We've waited for this model and we can tell you from now that it will be amazing! With the 2014 911 (991) Targa, Porsche is returning to its roots as the new model is inspired by the original version that was produced between 1960s and until 1980s.
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The importance of active learning and practice on the students' mastery of pharmacokinetic calculations for the intermittent intravenous infusion dosing of antibiotics
Approaches to teaching and learning
Estimation of pharmacokinetic parameters after intermittent intravenous infusion (III) of antibiotics, such as aminoglycosides or vancomycin, has traditionally been a difficult subject for students in clinical pharmacology or pharmacokinetic courses. Additionally, samples taken at different intervals during repeated dose therapy require manipulation of sampling times before accurate calculation of the patient-specific pharmacokinetic parameters. The main goal of this study was to evaluate the effectiveness of active learning tools and practice opportunities on the ability of students to estimate pharmacokinetic parameters from the plasma samples obtained at different intervals following intermittent intravenous infusion.
An extensive reading note, with examples, and a problem case, based on a patient's chart data, were created and made available to students before the class session. Students were required to work through the case before attending the class. The class session was devoted to the discussion of the case requiring active participation of the students using a random participation program. After the class, students were given additional opportunities to practice the calculations, using online modules developed by the instructor, before submitting an online assignment.
The performance of students significantly (
Despite being a difficult subject, students achieve mastery of pharmacokinetic calculations for the topic of intermittent intravenous infusion when appropriate active learning strategies and practice opportunities are employed.
Intermittent intravenous infusion (III) is a mode of drug administration whereby the drug is administered through short intravenous infusions at regular intervals. This method of drug administration may be useful for avoiding dangerously high concentrations that may be achieved by intravenous bolus administration. Additionally, the short infusion time masks the distribution phase, therefore minimizing problems associated with the interpretations of the plasma concentration-time data for drugs that follow multicompartment kinetics.
Important drugs that are administered by the III method are aminoglycosides and vancomycin, which are usually administered by 30–60 min short infusions
There are subtle differences between the III and multiple bolus dosing of drugs in terms of estimation of some pharmacokinetic parameters such as maximum plasma concentration (Cmax) and volume of distribution (V). The main reason for these differences is a relatively significant elimination of the drug during the drug input (short infusion) for the III mode, as opposed to a negligible elimination of the drug during the bolus input. Consequently, the Cmax after III, which occurs at the end of the short infusion, is always less than the maximum concentration after the intravenous bolus dosing (Co), which occurs immediately after the bolus dose (Figure
Figure 1
Plasma/serum concentration-time profiles of a drug administered by intermittent intravenous infusion or intravenous bolus method
Plasma/serum concentration-time profiles of a drug administered by intermittent intravenous infusion or intravenous bolus method. Solid and dashed lines represent the intermittent intravenous infusion and intravenous bolus methods, respectively. Abbreviations: Co = maximum concentration after the bolus dose; Cmax = maximum concentration after the short infusion; tinf = length of short infusion; Cmin = minimum concentration.
Additionally, a common practice for sampling at steady state for drugs administered through III is to obtain the peak and trough samples from two subsequent dosage intervals: a trough sample is taken first, followed by the infusion of the next dose and collection of the peak sample
Educational context
Basic Pharmacokinetics is a 3-semester-credit-hour course that is offered synchronously, using videoconferencing technology, to the local (Amarillo) and distant (Abilene) campuses twice a week with 75 min of instruction time for each session. Although most of the instructions initiate from the Amarillo campus, where the author resides, a second instructor is located in Abilene to assist the students inside and outside the classroom. The course is offered during the second year (P2) of a 4-year Pharm.D. program and runs throughout the fall semester with 16 weeks of instruction, excluding holidays. The prerequisites for the course are P2 academic standing and successful completion of a Principles of Drug Action course that is offered during the spring semester of the first year. The teaching format of the course is based on the active learning principles applicable to large classrooms, as described in more detail in the following sections. For the fall of 2011, the class had a total enrolment of 152 students, with 114 students on the Amarillo campus and 38 students on the Abilene campus.
The overall outcomes of the course are presented in Table
To achieve the stated outcome and learning objectives (Table
Descriptions of the major elements of the reading notea
A reading handout was prepared by the instructor, which was made available to students online via the course website. The reading note starts with the expected outcomes and learning objectives for the lesson (Table
Estimation of the elimination rate constant (k) and half life (t1/2)
First, the simple situation when the peak and trough samples are taken from the same interval is discussed. For this method, the calculation of
where Ttrough and Tpeak are the sampling time of peak and trough, respectively. Subsequently, t1/2 may be obtained using
Additionally, a major emphasis is made on the estimation of
Figure 2
Chart data
Chart data. Excerpts from a patient's chart data containing the medication administration record and laboratory (plasma concentration-time) data after administration of multiple doses of gentamicin to a patient (A) and manipulation of sampling time of trough or peak or calculation of sampling time within the interval for use in equation (1) (B).
Figure 3
Serum/plasma concentration-time Profiles
Serum/plasma concentration-time Profiles. Serum/plasma concentration-time course of gentamicin after intermittent intravenous infusion in a patient after intravenous infusion of 80 mg of the drug over 30 min every 8 h, demonstrating the manipulation of peak or trough time (A) and calculation of sampling time for peak (Tpeak) and trough (Ttrough) within the interval (B). Solid triangles: peak and trough after the first dose; solid circles: peak and trough at steady state; dotted open circles: transposed peak or trough at steady state.
Similarly, the peak concentration taken 0.5 h after the infusion is stopped (4.68 mg/L) after the 5th dose is the same as that if it had been taken 0.5 h after the completion of the 4th dose (Figure
Another method for the estimation of Ttrough and Tpeak for substitution in equation (1) is to use the sampling time relative to the beginning of the dosing interval in which the sample is taken. In the example here (Figures
Estimation of Cmax and Cmin
In addition to the estimation of
This equation can be used for the estimation of drug concentration at any time when another concentration-time data (peak or trough) and
Estimation of volume of distribution
The notes also discuss the estimation of V for the first dose, steady state, and dosage intervals between the first dose and steady state using equations (4), (5), and (6), respectively, which are derived based on the Sawchuck-Zaske method
where Ro, tinf, τ, Cmax
∞, and Cpredose are the rate of infusion, length of infusion, Cmax at steady state, and predose Cmin, respectively. Additionally, the degree of error associated with the estimation of V using the bolus dose equations (7) (for the first does) and (8) (for the steady state), listed below, are discussed in the notes with numerical examples
The notes state that the degree of overestimation of V using the equations for the bolus route is dependent on the magnitude of difference between Co (if the drug were administered by IV bolus route) and Cmax. This means the longer the length of the infusion or the faster the decline in the plasma concentration (shorter half life), the larger is the difference between the Co and Cmax values, hence resulting in a higher overestimation of V
Estimation of clearance (Cl)
The discussion of the estimation of Cl for this topic in the notes is limited because this calculation (multiplying k by V) is not unique to this route of administration.
Practice problem for in-class discussionb
A practice problem was designed to cover the learning objectives of the lesson (Table
As with any other topic in the course, students were expected to work on the practice problem, consulting the reading note, before attending the class session.
Class session
During the first 10–15 min of the class session, the instructor briefly outlined the general concepts of the intermittent intravenous infusion and its potential applications. The remaining time of the session was then devoted to the discussion of the practice problem. The discussion was conducted by calling on students randomly, using an online registration process described previously
Online homework assignment
An online, interactive module was designed with a structure identical to the in-class practice problem using a system described before
To assess the effectiveness of the tools used to achieve the learning objectives of the session, an online pretest was given to students at the end of the class for the multiple dosing session, which was two days before the session on the III topic. The students did not have access to the notes, practice problem, or the online assignment/practice modules before the pretest. The pretest presented dosage regimen and peak and trough data for the steady state using the simulated chart data for a case when the trough sample was obtained before the next dose peak sample (similar to the data in Figure
A one-way ANOVA with repeated measures (4 assessments), followed by post-hoc Tukey's multiple comparison, was used to test the differences between the total grades of all students in different assessments. Additionally, to test the effect of location (Abilene and Amarillo) on the performance of students in the 4 assessments, the grades were separated based on the campus. A two-way ANOVA with repeated measures, followed by Bonferroni post-hoc tests, was then used for the statistical analysis of data.
The study was approved by the Institutional Review Board of Texas Tech University Health Sciences Center under the exempt status (IRB#: A11-3674).
A total of 126 students (34 from Abilene and 92 from Amarillo) completed all 4 assessments, and therefore, were included in the analysis. As demonstrated in Figure
Figure 4
Performance data for the entire assessments
Performance data for the entire assessments. Grades of students in Pretest, Posttest, Assignment, and Examination for the entire class (
The percentages of students who answered each of the questions related to
Figure 5
Performance data for the individual questions
Performance data for the individual questions. Percentages of students who answered each of the four questions correctly in Pretest, Posttest, Assignment, and Examination (
As for the use of online practices, an overwhelming majority of students (88.1%) generated one or more practices before the submission of the online assignment, as opposed to only 11.9% of the students who did not generate any practices. Of those who generated practices, 55.5%, 19.0%, and 7.1% generated one, two, or three practices, respectively. The remaining students (6.3%) generated ≥ 4 practices. The linear regression analysis of the assignment grades against the number of generated practices for students who generated 0–3 practices (94% of students) are presented in Figure
Figure 6
Effects of online practice generation on the online assignment grade
Effects of online practice generation on the online assignment grade. Grades of students in the online assignment as a function of the number of online practices generated before the submission of the assignment. The percentages of students who generated zero, one, two, or three practices were 11.9%, 55.5%, 19.0%, and 7.1%, respectively. Symbols and bars represent mean and SEM, respectively.
The main goal of the instructor for the III session was to design learning tools for students so that they learn how to estimate major patient-specific pharmacokinetic parameters after this route of administration. To accommodate the requirements of some Advanced Pharmacy Practice Experience rotations that students be able to estimate the kinetic parameters using the patient chart data and plasma concentrations taken from two intervals, learning tools were designed with special emphasis on these requirements. The performance data presented in Figures
It could be argued that the students' performance in the take-home assignment is inflated relative to the other tests because of two main differences between the assignment and other tests. First, other than a due date and time, the assignment lacked the time stress present for the other tests. Therefore, students could spend as much time as they needed for each question while answering the assignment questions. Second, whereas the pretest, posttest, and mid-term exam were not open book (except for provision of an equation sheet), students had access to all course materials for the take-home assignment. Therefore, one might expect that the performance of the students in the mid-term exam to be lower than that in the assignment. Although the grades of students in the mid-term exam (83%) were lower than those in the assignment (89%), this difference did not reach statistical significance (Figure
At Texas Tech School of Pharmacy, the courses offered during the first and second year of the pharmacy curriculum are delivered synchronously to Amarillo and Abilene campuses. The instruction may be initiated from either campus depending on the location of the instructor. For the Pharmacokinetics course, all the sessions initiated from Amarillo. Therefore, the Abilene campus was considered the distant campus. To assure equality of performance between the two campuses, all the performance data were routinely monitored separately for the two campuses. As shown in Figure
The performance data on the individual questions (Figure
Although the trend for the Cmin data was similar to that for
In conclusion, learning tools used in a basic pharmacokinetics course offered to second-year pharmacy students are presented here for the topic of intermittent intravenous infusion. In addition to the estimation of pharmacokinetic parameters from the plasma concentrations obtained during one interval, emphasis was placed on a unique case when peak and trough are obtained from two separate dosage intervals at steady state. Additionally, simulated chart data were used to present the dosing schedules and laboratory data. Although students were familiar with the estimation of elimination rate constant before the introduction of the intermittent intravenous infusion topic, >95% of them could not estimate the elimination rate constant accurately when the peak and trough samples were from two separate intervals. Active learning exercises and practice opportunities employed for this topic substantially facilitated students' mastery of these calculations, as evidenced by performance data.
aA complete copy of the reading note is available from the author by request.
bA complete copy of the practice problem is available from the author upon request.
Competing interests
The author reports no competing interest.
Authors' contributions
RM designed and carried the study, analyzed the data, and wrote the manuscript.
Authors' information
RM, PharmD, PhD, is a Professor of Pharmaceutical Sciences who has taught basic and clinical pharmacokinetics courses to pharmacy students for over 25 years. He has developed numerous active learning strategies for teaching pharmacokinetics, for which he has received several awards including Innovation in Teaching Award from the American Association of Colleges of Pharmacy and President's and Chancellor's Awards in Teaching from the Texas Tech University Health Sciences Center.
Gentamicin therapy administered by intermittent intravenous injections
Clinical usefulness of vancomycin
Aminoglycoside antibiotics
Pharmokinetics of dosing regimens which utilize mutiple intravenous infusions: gentamicin in burn patients
Confounding issues in estimation of patient-specific pharmacokinetic parameters and dosage individualization of aminoglycosides
A participation requirement to engage students in a pharmacokinetics course synchronously taught at a local and distant campus
On-line, individualized, and interactive pharmacokinetic scenarios with immediate grading and feedback and potential for use by multiple instructors
Pre-publication history
The pre-publication history for this paper can be accessed here:


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|Alexei Kosut <ako...@nueva.pvt.k12.ca.us>
|Re: conditional HTML
|Sat, 13 Apr 1996 01:35:14 GMT
On Tue, 9 Apr 1996, Randy Terbush wrote: > One thought that I have had in the back of my mind is to split the > modules into their own directory. Teaching configure to build a > list from the modules in this directory, and perhaps a --with > tag to point it to a directory full of local modules would do the > trick. I'm not sure about that, but one thing I think would be nice is a rearrangement of the way Apache's files are packed for the distribution. The src directory is getting rather large, enough so that a ls, after one has compiled, will more than fill a screen, which could cause a user to miss the README and INSTALL files. I suggest the following: We move all user-related files (README, INSTALL, Configuration, Makefile, etc) to the root directory. This way they don't even have to look at the source if they don't want to, nor do they have to figure out where it is. They can just type 'make' and go. I'd also like to see an autoconf-like setup. I haven't gotten a chance to look at the one Tom Tromey mentioned, but something like that would be good. As well, I'd like to see the non-'core' (i.e. NCSA 1.3) modules moved into their own directory, modules/ maybe, along with a file to configure them. This makes sense, as it makes the modules more modular, and gives (I think) the end user more of a sense that it's okay to fiddle with them, without breaking or damaging the server. Finially, have the compilation dump the binary into the root directory along with everything else. This, as well, brings the user away from the source, as I'm sure many of the users of Apache (tens of thousands of them) are not programmers, and have no desire to be. Also, this makes someone worried about disk space (Apache 1.1 is almost 4 megs fully compiled) who does an "rm -rf src" (and saves two megs) not shoot themselves in the foot. I think this would all make Apache more user-friendly. Thoughts? -- ________________________________________________________________________ Alexei Kosut <firstname.lastname@example.com> URL: http://www.nueva.pvt.k12.ca.us/~akosut/ Lefler on IRC, DALnet <http://www.dal.net/>
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text: YouWin comments on payout complaint By SBR Thursday, November 19, 2015 Share with: Online sportsbook YouWin (SBR rating C+) has provided comment on the payout complaint reported earlier in the week. A player had claimed that he requested to be paid $700 CAD on October the 13th. The player indicated that while the sports betting said processed the withdrawal the next day, he has yet to receive payment back to the card he used to make his deposit. YouWin confirmed that they processed the withdrawal within 24 hours - which is in accordance with their advertised processing time-frame for card withdrawals - and that they provided the player a copy of the transaction number supplied by the processor used to issue the withdrawal. The player provided a copy of his bank statements to show that he has yet to receive the payment. YouWin has asked that the player's bank sign a form certifying that the transaction did not post to his bank account, but the player has claimed that his bank is unwilling to do so. SBR has asked if bank printed statements signed by a notary would be sufficient for payment to be reissued through an alternate payout method. The payout complaint remains outstanding.


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|Thom May <t...@planetarytramp.net>
|Re: coredumps on Linux
|Wed, 05 Mar 2003 23:51:22 GMT
* Greg Ames (firstname.lastname@example.com) wrote : > I mentioned this to other Apache folks around here and got some interesting > reactions: > > * If we don't control this with a directive, we might violate the rule of > least astonishment. For example, admins might be living with some buggy > modules, and all of a sudden their disks fill up with unwanted coredump > files. (Of course ServerRoot or CoreDumpDirectory would have to be > writable by the httpd User for that to happen.) agreed; that really wouldn't be too pleasant! > > * If we do control this with a new directive and we don't make it very > clear that this is just a Linux 2.4+ thing, users might think that turning > on the new directive will magically solve all lack-of-coredump issues. It > won't...there are Linux kernels < 2.4, ulimit -c, permission issues, and > the CoreDumpDirectory directive to name a few things, not to mention > sysadmin stuff you have to do on FreeBSD and Solaris. > > One solution might be to control it with CoreDumpDirectory. If that's in > the config file, one would assume the admin wants coredumps on failures. > Once more, I have to agree - I only have CoreDumpDirectory enabled when I'm actually chasing down problems - I never enable it for production servers. However, we should document very clearly and obviously that setting CoreDumpDirectory will now produce cores even as root; it's entirely possible that some admins don't remove the directive because they *know* that we don't produce cores when running as root. > > I'm also curious about how admins with Linux production sites are dealing > with seg faults etc. today if they are not getting coredumps. > generally i run apache as a different user on a different port but with the exact config I want for >48 hours before taking it live, that usually sorts out any problems one way or another - if I do start seeing segfaults as root then the only usual recourse is firing up gdb and running in single process mode. This patch would be very useful in that respect. +1 from me to have CoreDumpDirectory be able to enable core dumps from root owned processes. Cheers, -Thom > Thanks, > Greg
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This documentation is archived and is not being maintained.
CodeTypeRef.DTE Property
Visual Studio 2005
Gets the top-level extensibility object. Namespace: EnvDTE
Assembly: EnvDTE (in envdte.dll)
Assembly: EnvDTE (in envdte.dll)
In Visual Studio, the DTE object is the root of the automation model, which other object models often call "Application".
The values of code model elements such as classes, structs, functions, attributes, delegates, and so forth can be non-deterministic after making certain kinds of edits, meaning that their values cannot be relied upon to always remain the same. For more information, see the section Code Model Element Values Can Change in Discovering Code with the Code Model (Visual Basic).


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Islendingadagurinn - Icelandic Festival of Manitoba
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Join us August long weekend for the 128th Annual Islendingadagurinn on August 4th, 5th, 6th, 7th, 2017. Visit the heart of New Iceland, Gimli, Manitoba - just 1 hour North of Winnipeg, Manitoba, and celebrate family, friends and Icelandic heritage and culture.
Islendingadagurinn, as far as we have been able to determine, is the second oldest continuous ethnic festival in North America. Velkomin (welcome), and enjoy the food, events, activities and of course, the Vikings!


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