text:
Business Development Manager
Business development Manager- Field based Location: Midlands/South west England Salary: £45,000 - £50,000 Benefits: Company Car allowance, Highly Competitive Pension and Flexible Benefits An exciting opportunity has arisen with a highly regarded and well respected Financial Services Provider. They are looking to add an experienced face to face Business Development Manager to the very successful Mortgages Proposition team on a permanent contract. This is a field sales based role which will cover either the South West or Midlands. The main purpose of this role will be assisting the mortgage proposition to the intermediary mortgage market and establishing the bank as a key lending partner with those identified relationships. Key responsibilities also include: Building and developing strong one to one relationships The day to day development and management of the intermediary mortgage partners Ensuring business volumes and P&L targets are delivered in line with quality standards and customer requirements Seeking opportunities to grow and develop the intermediary business Develop and maintain strong business relationships with panel Intermediaries Take ownership of your own development by ensuring that you have a clear and defined development plan that you continually review and work towards. The following Qualifications/ personal & technical skills will be essential: Qualified to Certificate in Mortgage Advice and Practice (CeMapp) Experience in an intermediary residential and buy to let mortgage development role Strong presentation, communication and interpersonal skills Full driving license Retail banking product knowledge Strong understanding of intermediary mortgage market If you feel this role would suit you and would like further information please do not hesitate in contacting me, call Jayd Venters This job was originally posted as www.cwjobs.co.uk/job/66870708


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Let us know when your receive great advice so we can thank our lawyers and point others with similar questions in the right direction.Got it!
I found these sentences on my mortgage document:
"MERS is a separate corporation.....MERS is the mortgagee..."
"MERS is nominee solely for the lender (and the lender's successors and assigns), and the successors and assigns of MERS"
"For this reason, borrower grants to MERS (and it's successors and assigns) all of borrower's title interest in the property"
"MERS is the beneficiary".
Are they "written statements" and if so, who is considered as making them? are they considered "statements made by MERS" or "statements made by the lender" (I was told that although MERS is named as mortgagee, MERS is not a party to the transaction).
The mortgage is printed on a standard Fannie Mae Single Family form.On my mortgage is named the lender, MERS, and I. But, the lender did not sign. I am the only signatory, and the lender says MERS is not a party to the transaction. If the lender made the statement that all my interest in the property is being transferred to a separate corporation, that could mean that the lender negated my right to rescind at the closing table - if MERS made the statement, then MERS negated my right to rescind. I it is to be construed that I, myself, made that statement, then the lender fraudulently induced me to waive my right to rescind. So, who made the statement on my mortgage?
Not sure what your point, or question, is. Since they are sentences in your mortgage, then are by any practical definition "written statements" but there's a reason for the term "written statements" and so it may not be the case......Point is also without seeing the documents it's really impossible, and inappropriate, to give you a firm answer. And MERS may simply be a company that holds mortgages to administer them for the actual lenders, who can change if the loan is assigned...... MERS may also be the loan servicing company.... But where are you going with this?
The response given is not intended to create, nor does it create an ongoing duty to respond to questions. The response does not form an attorney-client relationship, nor is it intended to be anything other than the educated opinion of the author. It should not be relied upon as legal advice. The response given is based upon the limited facts provided by the person asking the question. To the extent additional or different facts exist, the response might possibly change. Attorney is currently licensed to practice law only in the State of Illinois. Responses are based solely on Illinois law unless stated otherwise.Ask a similar question
If you are looking at this by way of defending a foreclosure, you should know that the Judges in Cook County - and the Appellate Court of Illinois, will accept MERS as a servicer and acknowledge that whatever entity gets an assignment of the Mortgage and Note has standing to bring the foreclosure. Although in states like Ohio and Kansas and New York are much more protective of mortgagors (borrowers) with the assignments of Mortgages, Illinois is not that enlightened.
This answer does not constitute legal advice and does not and is not intended to create an attorney-client relationship. The law may vary depending on the state in which you reside. It is intended only to give some direction in which to seek assistance.Ask a similar question
I'd just like to add that if you want to do a little light reading on MERS as a party in interest, the information is right on their web site at http://www.mersinc.org/Foreclosures/index.aspx. There's a link on the page to the MERS legal primer, which provides case law on that issue. If you are in foreclosure, I recommend consulting an attorney.Ask a similar question
Property title Foreclosure Home mortgage Real estate Appeals
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subset: commoncrawl


text:
Contact Info
Address:C-20, Ground Floor,
Sector-2, Noida-201301
You are Here: Home >> Property in Noida >> Residential Property >> Hyde Park
Since after the inception in 1993, Nimbus Projects Ltd has indulged in various domains and has grown leaps and bounds and is a force to be reckoned with. They hold unique stardom in investment advisory, project management and construction arena in Delhi-NCR, accompanied by perfection, excellence and top notch quality in every action.
Their high proportion residential project Hyde Park is the latest to glorify their name. Sprawling across 15 acre, the project will be weaving some impressive collection of 1/2/3/4 BHK apartments. This modern day venture will be poised in sector 78 which is a graced by healthy civic amenities like banks, schools, metro station and hospitals.
Hyde Park is blessed with amenities like swimming pool, jogging track, medical center, sporting facilities, green spaces, amphitheatre and many more. The project is put up on the green building concept, which is the new era buzzword in the residential segment. Both end users and planned investors are getting a golden investment opportunity in real estate with Hyde Park in sector 78.
The eventful sector 50 is located just 3 km from Hyde Park. The closeness to DND Flyway, Atta Market and SEZ will ring right for us to advance with investing in Hyde Park. In the foreseeable future occupants will also have the new metro station in the close proximity of Hyde Park. So park your investments with Hyde Park in Noida sector 78 and live with prosperity.
Let's Talk About Your Dream Property


text:
Fixing code
Bajet $10-30 USD
I have a code that needs to be fixed.
36 pekerja bebas membida secara purata $26 untuk pekerjaan ini
Hello I'm interesting your project very well I'm a Good Java, Math, Algorithm expert. I m quite well experienced in these jobs. Let's go ahead with me I want to service for you continously. Thanks
I did this before for other people, I also can do the debugging and find the issues quickly, like break-point, drop to frame, condition expression Below are the websites I wrote with back-end language Java and J2EE Lagi
hello. Hope to work with you in this project. -----------------------------------------------------------------------------------------
mynextech.com/moderniwebystories mynextech.com/moderniweby capsize.tv (Streaming Website with Admin Panel) myfitregimen.com (fitness wordpress blog) mynextech.com/unioncreditbank (Small Internet Banking Portal) my Lagi
Hi, Please tell me more about the script so we can discuss more then I can check and send you report. Regards, Tan.
Hi there, I am very much interested in Fixing this code for you and would like to know more about the fix/task you need done, awaiting your reply


text:
Serves: 10-12
Preparation time: 25 minsCooking time: 35 mins
Dietary guidance: v
Tags: main · cheese · pasta · italian · meatless ·
1 package (12 oz) San Giorgio Jumbo Shells, uncooked
4 cups (2 lbs) ricotta cheese
2 cups (8 oz) shredded mozzarella cheese
3/4 cup grated Parmesan cheese (plus more to top: optional)
3 eggs
1 Tbsp. chopped fresh parsley
3/4 tsp. dried oregano leaves
1/2 tsp. salt
1/4 tsp. ground black pepper
3 cups (28 oz jar) spagetti sauce
Cook pasta according to package directions. Combine cheeses, eggs, parsley, oregano, salt & pepper. Fill each pasta with about 2 Tbsp. cheese mixture. Spread a thin layer of sauce on bottom of a 13 X 9-inch baking pan. (My personal note: I had to break out another pan and additional spagetti sauce to use up all of the shells and cheese mixture...so be prepared to make more than this says.) Place pasta in the pan; cover with remaining sauce. Sprinkle with additional Parmesan cheese, if desired. Cover with aluminum foil; bake at 350F about 35 minutes or until hot and bubbly. 10 to 12 servings.


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Fare shown is not including the Government's "Public Transport Fare Concession Scheme for the Elderly aged 65 or above and Eligible Persons with Disabilities". For details of the scheme, please click here.
Click here for the coverage of relevant Bus-Bus Interchange Concession Schemes.
The journey distanceFrom Cyberport to So Uk Estate : 17.7 kmFrom So Uk Estate to Cyberport : 18.5 km
The journey time is 75 mins approx.


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"Hey Ahsoka want to see me put my whole fist in my mouth!"
-announcement: "Do not forget that you all get your paychecks today, that is all."-
"Damn I forgot we get our paychecks today!"
"We better go before the line gets long Snipps." Anakin and Ahsoka ran out they're rooms and made it to the line
"Aww F**k! F**k F**k F**K! Why did i f****n forget! What the F**k? This line will take a f****n year! Good F****n Lord!
"Master Skywalker, Jesus Christ, calm down there's only four jedi's in front: Master Fisto, Master Koon, Barriss, and Master Windu I bet this line would go by quickly besides its not like Master Kenobi is here to annoy us about Kim Kardashian again!"
"Haha yeahh I guess your right Snipps!"
"Heyy Ahsoka, Heyy Anakin!"
"Aww F**k! Hello Obi-Wan, thanks alot 'Soka"
"Damn I didn't think that would happen!"
"What would happen?"
"Nothing, Master!"
"Anyways, did you guys hear that Kim Karda-"
Everybody in Line: "WE DON'T CARE!"
"You all are just jealous little f**ks because she loves me and not you!"
"Master Kenobi could you just shut the f**k up!"
"Snipps don't even listen to him." While they all we're ignoring Obi-Wan they all saw Master Fisto's envelope. As he walked passed Anakin, Anakin stopped him.
"Woah Master Fisto hold up, aren't you going to open the envelope and see what your pay was?"
"Anakin I want to be surprised, I am going to open the envelope when I get to my room."
"C'mon Master just this once I've seen everyone's reaction but yours and Master Windu just open the damn thing."
"Alright Anakin." When Kit opened the envelope and saw the check he was in shock!
"What the F**k is this bulls**t checl?! I'm the most f****n calm jedi ever and you think I am going to accept this? F**k that!" he left and flicked everyone off. Everyone just stared with they're mouths wide open.
"Okayy that was a little weird."
"Your telling me Ahsoka I've never seen Master Fisto so angry. He wasn't even this angry when I accidentally broke his nose playing Wii Sports when I punched his face playing tennis but luckily we lost 40 pounds."
"Look Master Koon just got his check lets see his reaction!"
"AWWWW F**K YEAHH BITCHES!" Master Plo ripps his shirts and swings it around then humps a nearby plant and leaves laughing!
"Sooo... was he happy?"
EVERYONE: "Lord knows."
"Aww yeahh Barriss is next, this outta be good." Barriss calmly opens the envelope, smiles, and walks to the exit door.
"Typical Barriss!" They all Boo her and clones came out throwing tomatoes at her.
"Well we all know what the clones spent they're money on." Everyone Boos at Ahsoka's stupid joke and they all give her punchies.
"Oh thank God I'm next after Master Windu!"
"See Anakin, I told you this wasn't soo bad now lets watch Master Windu's response!"
"HELL YEAHH NIGGA!" Everyone Looks at him in complete shock.
"I mean... Very Good carry on! Then he runs like hell.
"Holy S**t I'm up!" Anakin walked up to the droid and got his check. He opens the envelope and see's he gets $300,450.
"Oh My F****n God!" Anakin faints! Ahsoka steps over him and gets her check.
"F**k Yeahh! This enough to buy me a month's worth of PORN MAGS." Anakin wakes up.
"What Snipps?"
"I mean Korn, ya know my fav band woo."
"Oh ok then in that case..." Anakin faints again and Ahsoka walks back slowly then runs out the Jedi Temple. Obi-Wan steps over Anakin and gets his check. He puts it in his pocket. He picks up Anakin's check and made a funny discovery.
"Hahaha OMG they made a mix up you get $199 while Master Yoda gets the $300,450" Anakin gets up.
"What? No way let me see!" Once Obi-Wan hands Anakin the check he runs out the Jedi Temple fast as lightning!
"What the f**k? Oh well I have enough money to buy that Playboy with Kim Kardashian.


text:
Vogue 7184; ca. 1967; Misses' One-Piece Dress. High waisted A-line Dress has gathered skirt with front inverted pleat. With or without contrast. Puritan collar, full length sleeves have contrast cuffs with button-link trim. Self belts.
Featured in Vogue Pattern Book October/November 1967
Links to reviews/blog posts Edit
Sources/Vendors Edit
Gallery Edit
[insert your photos of this pattern made up]
Wishlist Edit
[insert your username, and make sure your preferences allow for people to contact you via e-mail. Do not list your email address here!]


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|Close Window
An examination in state surplus
C.B. Forgotston - Oct 31, 2013
Recently, Team Jindal announced a potential (unconfirmed) $162.9 million surplus for the fiscal year ending June 30, 2013.
Never failing to take credit for real or perceived good news (nor avoiding taking responsibility for bad news), Gov. Bobby Jindal was quick to pronounce that the surplus was due to "job growth."
Before the leges plan how to spend the extra cash, it's important to note that about this time last year the estimated surplus for the fiscal year ending June 30, 2012 was $130 million. When the surplus was officially confirmed in January of this year, it had dropped to $113 million.
Overlooked in the reports of the potential surplus are two factors that obviously contributed to most, if not all of it. The $129 million mid-year (December 2012) budget cuts to higher education and healthcare and a tax increase in the form of $31 million tuition hike at the public colleges and universities.
As to Jindal's claim that job growth is responsible for the surplus, it is just as logical to argue that the mid-year cuts and tuition increases were unnecessary.
It is also just as logical to conclude that the surplus was simply the result of inaccurate revenue estimates.
The bottom line is that there is no cause for any back-patting for this surplus.
Read More Stories at HeraldGuide.com!
|heraldguide.com is a supplement to St. Charles Herald Guide.
Copyright © 2001 - 2017 St. Charles Herald Guide, Inc. All rights reserved.
Please contact our WebMaster if you experience problems with the website.


text:
Almond Butter and Jam Sandwich
READY IN: 5mins
Recipe by nortocbaking101
This is my favourite sweet sandwich. Great for breakfast, lunch, or dinner.
Top Review by Lalaloula
What a great idea for a sweet sandwich! YUM! The jam and almond butter go great together and the nutty whole wheat bread was the perfect bread for this.
Ill definitely make this easy, tasty recipe again. THANK YOU SO MUCH for sharing it with us, nortocbaking 101.
Made and reviewed for one of my babies during PAC Spring 2012.
See Discussion:1 Review
Ingredients Nutrition
- 2 slice bread (I use whole wheat)
- 14.79 ml almond butter (I use Maranatha)
- strawberry jam (I use Crofter's)
Directions See How It's Made
- Put together as you would any sandwich, tastes even better if made ahead of time and put in the fridge.


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Brought to you by Rufty-Peedin Design Build
Thursday, October 3, 2016
Tragically, last week's most expensive commercial construction permit was issued to one of last week's least interesting projects: Building IV at Wade Park.
Maybe that's unfair: as far as office buildings built in pleasantly bland mixed-use developments, "The Offices at Wade" looks like it will be great: a four-story, Class A Office Building with an on-site gym and cafe and no interior columns. That last one might sound weird but it's actually kind of nice, especially if you've ever worked in an office building with too many of them. The project is also seeking LEED Gold Certification.
The contractor on the job, Choate Construction, received LEED Gold certification for Building III at Wade Park, so we imagine they will be able to do the same here. The $12 million permits were issued on October 26; The Offices at Wade is expected to open in the Fall of 2017, when it will rent out space for $28.50/square foot.
The next largest project from last week turned out to be even less interesting than a new office building: a new self-storage facility in an industrial area off Capital Boulevard. It's a $6.6 million job project that will be handled by McCrory Construction. The five-story, 119,200 square foot facility will operate under the Public Storage brand.
Earlier this year, we mentioned that site plans had been filed for a new CVS at the redeveloped Villages of Lake Boone; last week, a $1.25 million permit was issued to Project Builders for CVS Store No. 10863. The 11,537 square foot structure will be located at 2411 Landmark Drive. Note: we received some inquiries related to new, as-yet unreported development plans in the surrounding area that we're currently looking into.
In the renovation world, permits were officially issued last week to a structural engineering firm for repairs to the Boylan Bridge Brewpub, which closed down earlier this year after a busted fire sprinkler led to the collapse of a structural wall in the basement. Although the pub reopened in late September, its iconic patio has remained closed.
While work has been going on at the site for some time — the "applied date" on the permits is July 19, 2016 — we hope this official issuance means the pub will soon be able to reopen the beloved patio. We're very curious to see what the new view — which will now include Union Station — will look like. The $365,000 project has a somewhat humorous project work description "repair broken fire sprinkler." We imagine it's a little more involved than that.
Two eateries at the opposite end of the food chain — horrible pun very much intended — both received renovation permits last week: a Hardee's on Gorman Road at the Avent Ferry shopping center will be undergoing an $88,657 interior remodel, while Sitti Restaurant at 133 Fayetteville Street downtown will be spending $15,000 on a walk-in cooler. Not surprisingly, Empire Properties' in-house construction team, Empire Hard Hat, will be handling the latter job, while Commercial Millwork and Install will be taking care of the former. Also: we hope no Hardee's fans were offended by our lame joke: they probably have the best fast-food chicken strips out there and the fries are pretty decent.
A permit that made us look twice lists an $80,000 renovation for a doctor's office at 3004 Wake Forest Road that is apparently called "The Joint." While we thought at first this might be the Raleigh equivalent of those "Green Doctors" my dad wrote about seeing in California — despite the fact that naming a place doling out medical marijuana prescriptions "The Joint" seems a little too on the nose — it turns out this is just a regular old chiropractor's office. Oh.
Fortunately, we can wrap things up on a more interesting note, although it's not a renovation and it wasn't from last week: Crawford & Son, a new restaurant at 618 North Person Street that held its "soft opening" just yesterday, received ABC Permits on Tuesday of this week. WRAL's Out & About did a nice write-up on the place on October 25.


text:
Ricebridge XML Manager allows you to read and write very large XML files at high speed from within your Java application. You can use XPath to grab exactly the data you want without loading the entire XML file into memory.
|Software Development Libraries Java Libraries Office/Business Financial Information Management Records Management Database API
|Operating Systems
|POSIX Linux OS Independent Windows Mac OS X
A Fluent OpenStack client API for Java.
A TWiki appliance that is easy to use and lightweight.


text:
Sky Between Leaves London, UK
Sky Between Leaves is a London based alt-rock/Krautronica ensemble. The band's name was taken from Jarvis Cocker's story of the first time he wore glasses, realising that the holes in the trees were in fact the "sky between the leaves". The visual perception translates to the band's sound which takes us through feverish dreams and stroboscopic haze only to wake us to a deafening glittery reality. ... more
Streaming and Download help


text:
Mcleod Shelby GT500 RXT Street...
Mcleod 2010 GT500 RXT Street Twin Disc Clutch Kit (Street) Includes: Mcleod RXT Clutch Mcleod Lightened Steel Flywheel NOTE: The 2010 GT50...//Shop Now
This is the DSS 3-1/2 Aluminum shaft for the 1996-2004 Mustang. The Ford Motorsport Shaft is inexpensive but is also made from Extruded tube. Extruded Aluminum tube is inexpensive and is made by using something like a play-doh factory"
|Driveshaft Shop
|Free Shipping


text:
Tysons Corner: Less Density, Driven By The Market
"In Fairfax County's official vision for Tysons Corner, thousands of people live clustered around the Metro stops planned there -- riding the train or walking to work, leaving their cars at home and injecting new life into the austere glass and concrete hub.
But in the reality of developers' blueprints, a different Tysons is emerging -- one with a population smaller than what county leaders have in mind."
"At stake at Tysons is Fairfax's fundamental philosophy about growth in a county that has more than 1 million people, thousands of available jobs and little housing left."
Thanks to C. P. Zilliacus


text:
Using Microsoft Visual Studio to configure and set up driver deployment and driver testing is called provisioning a target computer or provisioning a test computer. For information about provisioning, see Provision a computer for driver deployment and testing (WDK 8.1). Here we show what happens when you use version 8.1 of the Windows Driver Kit (WDK) to provision a target computer.
When you provision a computer (WDK 8.1)
Provisioning a computer performs the following tasks:
- Copies installation files to %SystemDrive%\DriverTest
- Creates a user named WDKRemoteUser and switches to that user
- Installs .NET 4.0 if it is not already installed
- Installs Microsoft Visual C++ Redistributable
- Installs Test Authoring and Execution Framework (TAEF) (WDK Client)
- Installs debuggers
- Installs Windows Device Testing Framework (WDTF)
- Turns off AutoReboot
- Enables kernel memory crash dumps
- Disables Screen Saver
- Disables workstation lock policy
- Disables ForceGuest
- Sets the power policy to a high power configuration, which prevents the system from entering Standby or Hibernate Mode when idle
- Enables the RTC Wake timer
- Enables and configures kernel debugging
- Enables test signing of drivers
- Reboots the target computer if necessary
- Creates a system restore point
Removing provisioning from the target computer
Once you have provisioned a target computer, you cannot completely remove the provisioning. However, you can remove most of the provisioning from the target computer by using Visual Studio on the host computer. Here are the steps.
- On the host computer, in Visual Studio, on the Driver menu, choose Test > Configure Computers.
- Select the name of the target computer, and click Delete computer.
- Select Remove provisioning and delete computer. Click Next.
- When the removal process is complete, click Finish.
- Uninstall WDK Test Target Setup from the target computer.
When you remove provisioning (WDK 8.1)
When you remove provisioning from the target computer, these items are removed:
- Test Automation Framework
- Debuggers
- Windows Driver Testing Framework
- %SystemDrive%\DriverTest folder and contents
- WDKRemoteUser account
- Workstation lock policy
Removing provisioning does not change these items:
- Visual C++ Redistributable
- AutoReboot setting
- Kernel memory crash dump setting
- Screen saver setting
- ForceGuest setting
- Power policy
- RTC Wake timer setting
- Kernel debugging settings
- Test signing setting


text:
Skip to Content
(603) 225-2711
Home > Wellness > Health Library > Lumbar Spine MRI
Browse and register for related classes.
Image courtesy of Intermountain Medical Imaging,
Boise, Idaho. All rights reserved.
A side view of the lumbar spine shows normal discs, spinal canal, and
nerve roots (see figure 1). Nerve roots normally float in the fluid-filled
canal. Figure 2 shows a small herniated disc pushing into the canal toward
nerve roots.
ByHealthwise StaffPrimary Medical ReviewerWilliam H. Blahd, Jr., MD, FACEP - Emergency MedicineAdam Husney, MD - Family MedicineSpecialist Medical ReviewerRobert B. Keller, MD - Orthopedics
Current as ofFebruary 19, 2016
Current as of:
February 19, 2016
Healthwise Staff
Medical Review:
William H. Blahd, Jr., MD, FACEP - Emergency Medicine & Adam Husney, MD - Family Medicine & Robert B. Keller, MD - Orthopedics
This information does not replace the advice of a doctor. Healthwise, Incorporated, disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use. Learn how we develop our content.
To learn more about Healthwise, visit Healthwise.org.
© 1995-2016 Healthwise, Incorporated. Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated.
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Concord, NH 03301
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text:
Want to shop to your heart's content? Head to the following malls during the Great Singapore Sale for some late night shopping, dining, and entertainment!
Orchard Road
- [email protected] till 11pm every Friday & Saturday
- Orchard Central till 11pm daily
- TANGS Orchard till 11pm every Friday
Marina Bay
- The Shoppes at Marina Bay Sands till 11pm every Sunday to Thursday, till midnight every Friday & Saturday


text:
Traditional teak wood is united with sleek stainless steel and tinted glass. Silk rugs, sculpture, fine linens and crystal glasses adorn the yacht, and every detail has been thought of.
The 100-foot traditional Phinsi has a small crew including a dive master, a private chef, yoga teacher and therapist.
Alexa sails through beautiful seas visiting coral reef, untouched beaches with the opportunity to see Whales and Komodo dragons as well as witness mystical ancient ceremonies. Whilst on board the yacht, guests can dive into yoga and meditation or spend a day having heavenly spa treatments.
Top and or tail a stay on this sublime boat with a few nights at Oazia, Alexa's private villa on Bali.
Charles Knights
+44(0) 1285 651 010
Read more
Amy Waters
Charlotte Lawton
+44 (0) 1285 651 010
wildlife group tour
Indonesian Borneo - Orangutan Conservation
10 days from £3,395pp
View holiday
Highlights of Indonesia with Java
14 days from £3,795pp
Indonesia - Bali and Sulawesi
14 days from £3,195pp
Indonesia Family Holiday
14 days from £3,500pp
Indonesia Honeymoon
14 days from £3,995pp
View property
Raja Laut
Can't find what you're looking for?
Steppes Travel, 51 Castle St, Cirencester, GL7 1QD, United Kingdom


text:
Elastin is a main ingredient in our skin that allows it to stretch and spring back without leaving marks - our bodies produce less elastin as we age.
The elastin in Reviva Labs products is one of the most potent forms available.
1. The elastin supports the skin's own elastin structure, keeping skin firm and taut.
2. Elastin helps the skin maintain moisture, essential for keeping skin radiant and supple.


text:
Investigation into skydiving death nears completion
The Australian Parachute Federation (APF) says investigations into the death of a skydiver on the Sunshine Coast should be complete within the week.
The 32-year-old died on Kings Beach at Caloundra on Saturday.
APF chief executive Brad Turner says the skydiver was experienced and initial investigations have found there were no problems with his parachute.
"The skydiver's equipment was found to be in very good condition, so no problems there it would appear," Mr Turner said.
"Eyewitness accounts suggest he was flying under a perfect parachute immediately prior to the accident."
The APF's area safety officer for south east Queensland is conducting the investigation.
Mr Turner says it appears the tragedy was the result of a parachutist error.
"It would appear that the jumper had successfully deployed his parachute after completing a solo skydive," he said.
Mr Turner said while flying back to the landing area the parachutist was seen to commence an aggressive turn at about 45 metres.
"He commenced a turn perhaps too low to the ground to allow the parachute to level out - to fully recover for a normal landing and unfortunately he impacted heavily on the beach."
The APF has extended its deepest sympathy to the man's family and friends.
Mr Turner says making the sport as safe as possible is the APF's top priority.
"We always conduct thorough investigations into any parachuting accidents that occur in the interest of safety and education," he said.
"Hopefully we will have a definitive answer within a few days."
Topics: accidents---other, kings-beach-4551
First posted


text:
World Education Services
In a recent report by World Education Services (WES), Improving the International Student Experience, international students were surveyed on satisfaction with their education in the U.S. The report assessed international students from varying regions, including: China, India, Europe, Latin America & the Caribbean, the Middle East & North Africa (MENA), and Sub-Saharan Africa.
This post focuses on the European student experience in the U.S. based on research covered in the report. Please see the infographic below, and read recommendations for how you as a European student can improve your educational experience in the U.S.
For European students, 90 percent cited high satisfaction with their U.S. education overall, with 84 percent stating they would recommend their U.S. institution. In addition, 77 percent of European students said they were either satisfied or very satisfied with overall support to international students.
However, 72 percent of European students said they struggled with the cost of tuition and 26 percent cited issues when it came to adapting to the U.S. academic culture. Read the recommendations below to discover how you as a European student in the U.S. can improve in these areas.
Decreasing Tuition Costs
College fees and tuition tend to be much lower in European countries than in the U.S., so it's no wonder that the high costs of attending school in the U.S. can come as a shock to European students.
Luckily, there are multiple ways to alleviate the financial burden of a U.S. degree. See if your home country has any special scholarships or grants that they offer to European students earning an education abroad. Also, check with the university you will be attending to see what types of scholarships and financial aid packages they may offer. Once you've done your research and applied for financial aid through your government, your university, or both, look at websites that list scholarships and grants such as fastweb.com and cappex.com.
They key is to do your research and take the time to apply for financial aid. You may also be able to work part time and earn money while you're in school, so be sure to check what your visa will allow as well as with your university to discover opportunities.
Related articles:Adapting to U.S. Academic Culture
- How I found Financial Aid for My U.S. Education
- What is Financial Aid?
- How to Apply for Financial Aid
- Top 10 Universities for International Students Seeking Financial Aid
Academic culture in the U.S. requires students to complete a lot of individual work, and speaking with professors outside of the classroom is encouraged. Students in the U.S. also tend to spend less time in the classroom, and more time outside doing homework, studying, and working in groups. This is because college course grades in the U.S. tend to be based on a mixture of exams, attendance, small assignments, and group projects.
To successfully adapt to the U.S. academic environment, European students should first read through any course syllabi they are given by professors, so they know what to expect when they begin the course. Students should also reach out to professors if they need help and attend office hours. This way, students can begin building a relationship with the professor early on, which is especially important for professors in a student's major field of study. European students can also seek help and advice with international students services on their campus to find resources and receive advice on how to adapt to the U.S. academic culture.
Related articles:Are you a current or prospective European student and want to share your experiences as an international student in the U.S.? Apply to be part of our Student Ambassador Program!
- American Academic Culture: Finding Success in a U.S. Classroom
- Adjusting to the U.S. Education System
- Tips for Seeking Academic Resources and Help
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-----------------------------------------------------------------------------------------------------------------Kaitlin Ramby is the digital content producer for the WES Advisor team. An avid storyteller, Kaitlin is a writer of words and keeper of memes. She produces and manages a lot of the WES content and contributes to the overall content development and strategy. Kaitlin holds a bachelor's in journalism, has lived in both France and Hong Kong, and thoroughly enjoys helping others fulfill their dreams of studying and working in the North America region.


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Urotensin-II (U-II) is an endogenous peptide upregulated in failing hearts. To date, insights into the myocardial actions of U-II have been obscured by its potent vasoconstrictor effects and interspecies differences in physiological responses to U-II.
We examined the direct effects of exogenous U-II on in vitro contractility in nonfailing and failing human myocardial trabeculae (n=47). Rapid cooling contractures (RCC) were used to examine SR Ca2+ load. In nonfailing myocardium, exogenous U-II increased developed force (DF), rates of force generation and decline and RCC amplitude suggesting increased SR Ca2+ load. In isolated myocyte suspensions from nonfailing hearts, U-II increased phospholamban phosphorylation. In failing myocardium, exogenous U-II reduced DF and rates of force generation and decline without a significant change in RCC amplitude in trabeculae or a change in phospholamban phosphorylation in myocytes. To examine the effects of endogenous U-II, we administered the peptidic U-II receptor antagonist (UT-A) GSK248451A to isolated trabeculae. UT-A induced a decrease in DF in nonfailing myocardium and an increase in DF in failing myocardium. UT-A increased RCC amplitude slightly in both nonfailing and failing myocardium. During ongoing UT-A, exogenous U-II had little effect on DF and RCC amplitude, confirming effective receptor blockade.
U-II modulates contractility independent of vasoconstriction with opposite effects in failing and nonfailing hearts. Positive inotropic responses to UT-A alone suggests that increased endogenous U-II constrains contractility in failing hearts via an autocrine and/or paracrine mechanism. These findings support a potential therapeutic role for UT-A in heart failure.
Numerous studies have demonstrated activation of multiple endogenous neurohormonal systems in the setting of congestive heart failure,1, 2 and many of these systems have become targets for therapeutic interventions. In this context, recent studies have identified urotensin-II (U-II), a potent endogenous vasoconstrictor peptide, as a potential contributor to the pathogenesis and progression of human heart failure. In addition to the vasculature, U-II and its specific G-protein coupled receptor (UT) are expressed within the heart as well a variety of other organs (i.e. kidneys, adrenal, pancreas, thyroid and pituitary).
Circulating plasma levels of U-II are increased in humans with heart failure3-5, and these increases have been inversely correlated with ejection fraction6 and directly associated with increases in left ventricular filling pressures,3 dimension,6 and prognostic markers such as BNP3, 4 and endothelin-1.7 Moreover, several different studies have demonstrated an upregulation of the U-II system (both ligand and receptor) within the failing heart.6, 8, 9 For example, Douglas et al. observed strong expression of the U-II system in the cardiac myocytes and nonmyocytes of failing human hearts compared with lesser expression in the myocardium of patients with mild heart failure and little to no expression in nonfailing hearts.6
While studies have indicated that exogenous U-II can acutely modulate cardiac function, the pathophysiologic implications of increased U-II remains uncertain. Specifically, in vivo vasoconstriction and species-related differences in myocardial responses to U-II have impeded studies aimed at defining the functional role of U-II in heart failure. For example, in isolated-perfused rat hearts, exogenous U-II administration was associated with increases in coronary resistance, negative inotropy and increases in biomarkers indicative of acute cardiac injury.10 In this study, detrimental effects of exogenous U-II were even greater in the setting of ischemia-reperfusion injury where upregulation of UT was observed. However, in isolated human right atrial tissue, U-II was found to be a potent positive inotrope with responses implicating a PKC-dependent mechanism and increased phosphorylation of myosin light chain-2 (MLC-2).11 In ventricular trabeculae obtained from humans, the positive inotropic action of U-II was more potent than endothelin-1 or norepinephrine.12 Interestingly, while endothelin-1 has known differential effects in failing and nonfailing myocardium,13 there have been no direct comparisons of myocardial responses to U-II in the presence or absence of heart failure.
Accordingly, we investigated the direct effects of exogenous U-II on in vitro contractile performance in freshly isolated myocardial trabeculae from severely failing human hearts and from nonfailing control hearts. To examine potential autocrine/paracrine effects of endogenous U-II, we also examined the myocardial actions of acute U-II receptor antagonism (UT-A) on in vitro contractile performance. To provide insight into the mechanisms through which U-II is modulating contractility, we used rapid cooling contractures to examine the actions of U-II on sarcoplasmic reticulum Ca2+ load. In addition, we investigated the effects of U-II and UT-A on phospholamban phosphorylation in freshly isolated myocyte suspensions. Our findings indicate that the direct inotropic actions of U-II are qualitatively and quantitatively different in nonfailing and failing human myocardium and support a role for endogenous U-II in the regulation of myocardial contractility.
Human myocardium was obtained from patients with end-stage heart failure at the time of transplantation and from nonfailing donors whose hearts were deemed unsuitable for transplant. IRB-approved prospective informed consent routines for transplant recipients at the Hospital of the University Pennsylvania, and similar prospective consent for research use of nonfailing hearts through our local organ procurement organization (Gift of Life, Inc.) ensured ethical use of all tissue. Relevant clinical information including patient demographics, clinical history, medications and heart failure etiology was collected from all subjects who provided heart tissue. Myocardial perfusion with cold, 4:1 blood cardioplegia and prompt transport to the laboratory was performed as previously described.14 All in vitro physiologic evaluations were performed immediately and were concluded no more than 8 hours following tissue procurement.
In vitro muscle mechanics were assessed using previously described methods15 without modification. Briefly, human myocardial trabeculae were isolated from the right ventricular free wall and mounted in a slackened position in a custom designed isometric muscle chamber (Scientific Instruments, Heidelberg, Germany). The Ca2+ concentration of physiological buffer solution within the muscle chamber incremented gradually to a concentration of 1.75 mmol/L CaCl2. Following a 60 min. equilibration period, acute studies were conducted at 37°C and at a stimulation frequency of 0.5 Hz. Trabeculae were continuously stimulated by 3.0 ms asymmetric pulses with an energy that was 20% above threshold (typically 3-7 V). Experimental trabeculae length (L) was set to 80% of the difference between Lmax and L0 as previously described.15 Average muscle dimensions were 0.35 ± 0.01 mm wide, 0.32 ± 0.01 mm thick and 3.19 ± 0.10 mm long. Consistent with previous studies,16 we employed only trabeculae that had a maximal thickness of < 0.50 mm to ensure adequate tissue oxygenation. All experimental solutions were continuously bubbled with 95%O2-5%CO2 gas mixture to maintain a pH of 7.4.
The purpose of these studies was to determine the direct effects of exogenous U-II on in vitro contractile performance in failing and nonfailing human myocardium. Once stabilized at 0.5 Hz, steady-state (determined when developed force fluctuated less than 5% over a 3 minute period) isometric twitches were recorded (at 0.5 Hz) before and after bath application of the following U-II concentrations: 0.1, 1.0, 10, 100, 1000 nM. For these studies, we employed human U-II from GlaxoSmithKline (King of Prussia, PA).
To examine the effects of Urotensin-II receptor antagonism (UT-A) alone, steady-state isometric twitches were recorded (at 0.5 Hz) before and after administration of a UT antagonist (UT-A, GSK248451A, Cin-c[DCys-Pal-DTrp-Orn-Val-Cys]-His-amide)17 in failing and nonfailing trabeculae. Pilot studies demonstrated that 1 μM of this agent produces a maximal contractile response in human myocardial preparations (data not shown). To determine the ability of UT-A to block the contractile effects of exogenous U-II, isometric twitches were also recorded following application of U-II (1000 nM) during ongoing UT-A.
Trabeculae were mounted in a specialized muscle chamber conditioned to determine sarcoplasmic reticulum (SR) Ca2+ load by rapid cooling as previously described.18, 19 Under steady-state isometric conditions, electrical stimulation was stopped and trabeculae were rapidly cooled from 37°C to less than 1°C within 1 s. Rapid cooling releases all SR Ca2+ while simultaneously inhibiting SR Ca2+ uptake and sarcolemmal Ca2+ transport, resulting in the development of a tension contracture. Once the contracture reached a steady state, trabeculae were re-warmed and electrical stimulation was resumed. The amplitude of the tension contracture was measured as an index of SR Ca2+ load.
Left ventricular myocytes were isolated from both failing and nonfailing human hearts as previously described.20 A small aliquot of cells were removed from the cell suspension solution, and the viable cell number was counted using a hemacytometer (Advent Genetics, Ann Arbor, MI). Cells within the cell suspension solution were centrifuged, the supernatant was discarded and the cell pellet was resuspended in 1% BSA. Identical aliquots of cells (1.0 ml) were exposed to U-II (0.1, 10, 1000 nM), UT-A (1000 nM) or no drug at all (Baseline) for 20 minutes on a shaker (Biotech, Philadelphia, PA) at 25°C. Cells were centrifuged for 3 minutes, the BSA supernatant was removed and the samples were immediately frozen in liquid nitrogen for subsequent molecular analysis.
Phospholamban levels of phosphorylation were analyzed in isolated myocytes exposed to either U-II or UT-A using Western blot analysis as previously reported.21 The following antibodies were used: phospholamban (PLB; Upstate, Lake Placid NY) serine 16 and threonine 17 (phosphorylation site specific; PLB) (Badrilla, UK).
A Fisher's Exact Test was performed to examine potential differences in subject gender between groups. For continuous variables, results are presented as the mean ± S.E.M. For all hypothesis testing, a p-value of less than 0.05 was considered statistically significant. Differences in the absolute values of all contractile parameters as well as the values obtained through Western blot analysis were analyzed using a two-way repeated measures ANOVA. When the group by condition interaction was significant, pairwise within- and between-group comparisons were made using the Hochberg adjustment. Differences in the absolute change from baseline were determined between and within groups using two sample and paired t-tests, respectively. In these analyses, a Bonferroni adjustment was used to account for multiple pairwise comparisons and assure that values considered statistically significant achieved an experiment-wise p-value of <0.05.
The authors had full access to and take full responsibility for the integrity of the data. All authors have read and agree to the manuscript as written.
Clinical characteristics of subjects providing myocardial tissue are presented in Table 1. There were no significant differences between age and body weight between patients supplying nonfailing and failing myocardium. Among the failing hearts, 5 were from individuals with ischemic cardiomyopathy and 10 were from individuals with non-ischemic cardiomyopathy. Nonfailing hearts were rejected for clinical transplantation due to chronic hypertension (n=7), donors being over the age of 60 (n=6) or prior viral hepatitis exposure (n=1). The average ejection fraction was 17 ± 2% among failing hearts compared to 65 ± 6% among nonfailing hearts (# P<0.05).
Representative steady-state twitch tracings from U-II concentration-response experiments are shown in Figures 1A and 1B and absolute values of all contractile parameters are presented in Table 2A. U-II induced increases in developed force in nonfailing myocardium, but decreases in developed force in failing myocardium (Figure 1C). In addition, U-II increased the rates of force generation and relaxation (+dF/dt and −dF/dt) in nonfailing myocardium, but decreased the rates of force generation and relaxation in failing myocardium (Figures 1D and 1E). Though not precisely defined by these experiments, our findings suggest an EC50 between 0.1 and 1.0 nM for exogenous U-II in human ventricular myocardium. To examine whether intergroup differences in contractility are due to U-II-dependent alterations in SR Ca2+ load, RCC experiments were performed. A representative RCC tracing is shown in Figure 2A. In nonfailing myocardium, RCC amplitude increased significantly during graded increases in U-II but remained stable in failing myocardium (Figure 2B).
Absolute values of all contractile parameters are shown in Table 2B for both nonfailing and failing myocardium before and after bath application of UT-A (1000 nM) alone and upon subsequent administration of U-II (1000 nM). UT-A induced a mild decrease in developed force in nonfailing myocardium, but a pronounced increase in developed force in failing myocardium (Figure 3A). UT-A also increased both the rates of force generation and relaxation in failing myocardium, but had minimal effect on myocardium from nonfailing hearts (Figure 3B and 3C). RCC amplitude increased slightly following UT-A in both failing and nonfailing myocardium (Figure 4). Subsequent administration of U-II during ongoing UT-A had little effect on developed force, the rates of force generation and relaxation and RCC amplitude (Figure 3A, 3B, 3C and Figure 4).
Western blots were performed on freshly isolated human myocyte suspensions to determine the effects of U-II and UT-A on levels of phospholamban phosphorylation. Representative Western blots are shown in Figure 5A for PLB (serine 16 and threonine 17). PLB phosphorylation levels at serine 16 were virtually undetectable in both nonfailing and failing myocytes and were not altered by exposure to U-II or UT-A (Figure 5A). In nonfailing myocytes, U-II induced an inverse dosage-dependent phosphorylation of PLB at threonine 17 above baseline (Figure 5B) and had no effect on failing myocytes (Figure 5C) when the data was normalized by total PLB abundance. In addition, UT-A had no effect on the phosphorylation level of PLB at threonine-17 in both nonfailing and failing myocytes (Figure 5B and 5C).
The present studies demonstrate striking differences in the direct myocardial actions of exogenous and endogenous U-II in failing and nonfailing human myocardium. By using high quality isolated myocardial preparations under controlled in vitro conditions, our methods permitted fair assessment of pathology-related differences, independent of potentially confounding effects of in vivo vasoconstriction, loading conditions and/or other neurohormonal influences. In nonfailing myocardium, exogenous U-II increased developed force and the rates of force generation and decline in association with increases in the phosphorylation level of PLB at threonine-17 and RCC amplitude suggesting increases in SR Ca2+ load. However, in failing myocardium exogenous U-II did not increase developed force or the rates of force generation and decline in the absence of changes in PLB phosphorylation or RCC amplitude. Opposite positive inotropic responses to acute UT-A in failing myocardium suggest that endogenous myocardial or vascular U-II is modulating contractility via an autocrine or paracrine effect in the failing heart. These findings indicate modulation of myocardial contractility by endogenous U-II and suggest a potential therapeutic application of UT-A in patients with advanced heart failure.
The syndrome of heart failure is characterized by the chronic activation of several neurohormonal systems.22-24 Recent studies have identified the endogenous U-II system as a potential contributor to cardiovascular pathology, including heart failure. While U-II is present throughout the cardiovascular system and is upregulated in heart failure,3-6, 8, 9 the myocardial actions of U-II have been obscured by species- and disease-related differences.6, 10, 12, 25 In vivo myocardial responses to U-II may also be influenced by alterations in coronary vascular tone.26, 27 In this context, our use of isolated myocardial preparations from both failing and nonfailing human hearts to examine the actions of both exogenous and endogenous U-II on in vitro contractile performance, independent of alterations in blood flow, loading conditions and other neurohormonal influences, is unique among published studies to date.
In nonfailing myocardium, exogenous U-II increased contractility in a concentration-dependent manner. These findings are consistent with previous studies in which U-II increased contractile force generation in isolated human right atrial and ventricular trabeculae.11, 12 However, in nonfailing ventricular trabeculae we observed a greater positive inotropic response to U-II than previously reported results derived from a small number of heterogeneous human hearts.12 Beyond our larger sample size and segregation of failing and nonfailing hearts, our use of perfusion-based cardioplegia and very thin trabeculae without adrenergic-receptor pretreatment also may have contributed to the higher levels of developed force we observed under basal conditions and following U-II exposure. We also observed that U-II increased the rates of force generation and relaxation in nonfailing myocardium. These findings are consistent with increases in the efficiency of intracellular Ca2+ cycling, and the associated increases in the phosphorylation of PLB at threonine-17 and RCCs indicate that SR Ca2+ activity and load is indeed increasing in response to exogenous U-II in nonfailing myocardium. Our observations of an increase in PLB phosphorylation at threonine-17 suggests that the increase in SR Ca2+ load and developed force in response to exogenous U-II in nonfailing myocardium is mediated, at least in part, through CaMKII signaling.
In contrast, studies in failing myocardium revealed that exogenous U-II did not increase contractility and exhibited dose-dependent decreases in developed force and rates of force generation and relaxation. These divergent myocardial responses to U-II in the presence and absence of heart failure are analogous to the divergent vascular responses to U-II reported by Lim et al. in which vasodilation was observed in normal subjects and vasoconstriction was observed in heart failure.27 The lack of positive inotropic responses to U-II in failing myocardium were associated with an inability to augment RCC amplitude, suggesting an inability to augment Ca2+ cycling or SR Ca2+ load. In this regard, U-II had no effect on the phosphorylation levels of PLB at threonine 17 in failing hearts. Thus, the CaMKII-dependent PLB phosphorylation implicated in the ability of U-II to increase SR load and contractility in the nonfailing heart does not appear to occur with exogenous U-II in the failing heart. Though additional experiments with skinned fiber preparations (data not shown) did not indicate that U-II affected the force-Ca2+ relationship in nonfailing or failing myocardium, concerns about disruption of UT receptors and downstream signaling by cell permeabilization in these experiments do not permit us to exclude a direct action of U-II on myofilament Ca2+ sensitivity.
Our study indicates that UT-A induces a pronounced increase in contractility which is accompanied by an increase in the rates of force generation and relaxation in failing myocardium. Given that these responses were observed in an isolated tissue preparation, our findings suggest that elevated endogenous myocardial U-II exerts a negative inotropic action via an autocrine and/or paracrine mechanism that is independent of changes in tissue perfusion, loading conditions or circulating neurohormonal mediators in the nonfailing human heart. In addition, positive inotropic responses to UT-A in failing myocardium suggest that the limited response to exogenous UII may be due to previous receptor occupancy. Several factors support the conclusion that responses to UT-A are consequent to inhibition of endogenous tissue U-II activity. First, recent studies demonstrate that GSK248451A is a potent peptidic antagonist with minimal intrinsic activity and high specificity for the U-II receptor.17 Indeed, in the present study, administration of high-concentration exogenous U-II during ongoing UT-A exposure, induced virtually no physiological changes in both failing and nonfailing myocardium. The fact that contractile responses to UT-A were different in failing and nonfailing myocardium also argues against nonspecific responses. Finally, the observations that contractile responses to UT-A tended to be the inverse of the responses to exogenous U-II in the failing myocardium suggests that UT-A modulated the effects of endogenous U-II within the myocardial tissue.
Overall, the present studies suggest that endogenous U-II is a negative regulator of cardiac contractility in patients with advanced heart failure. This conclusion is based on previous studies demonstrating increases in myocardial U-II expression and content in failing human hearts,6 our demonstration that exogenous U-II has negative inotropic actions in failing myocardium that are independent of perfusion or loading conditions, and the demonstration that UT-A increases contractility in an isolated tissue model. The positive inotropic effect of UT-A in failing myocardium occurs as a result of an inhibition of endogenous U-II to negatively regulate myocardial contractility. Though the present studies do not address whether the contractility modulating actions of U-II and UT-A will be sustained or attenuated during longer time frames, preclinical data indicate that chronic UT-A treatment reduced adverse cardiac remodeling and lung congestion at eight weeks following experimental myocardial infarction in rats.28 Recent studies also implicate U-II in calcineurin-mediated hypertrophic signaling in human hearts.29 Thus, our findings further support an emerging therapeutic role for UT-A in the treatment of patients with advanced heart failure.
Effective evidence-based pharmacotherapy for congestive heart failure (HF) consists primarily of agents that modulate endogenous vasoactive substances to exert favorable effects on the myocardium and/or peripheral vasculature. Some agents, like angiotensin antagonists, have little or no direct effects on myocardial systolic performance, yet produce favorable effects on the HF syndrome. Though beta-adrenergic receptor blockers may induce acute negative inotropic actions necessitating gradual dose titration, they ultimately achieve beneficial effects on myocardial performance. Interestingly, virtually all drugs with acute positive inotropic actions have proven ineffective as disease modifying therapies for heart failure. In this context, the present studies indicate that endogenous U-II is a negative regulator of cardiac contractility and that acute UT-A induces moderate positive inotropic actions in failing human myocardium. Given prior studies showing reduced adverse cardiac remodeling in animals, our results provide support for clinical trials examining the effects of UT-A on cardiac contractility and clinical outcomes in heart failure patients. Recognizing that many promising new therapies were ultimately found lacking when examined in patients already treated with angiotensin antagonists and beta blockers, trials of UT-A should be performed in patients who are already being treated with these agents. However, if a beneficial effect of sustained UT-A treatment is ultimately observed, it would counter the concept that all agents with acute positive inotropic actions are detrimental in favor of a paradigm that makes distinctions based on the mechanism through which contractility is supported.
The authors would like to thank the Heart Failure and Transplant nurses at Penn, Cardiothoracic surgeons and operating room staff at Penn, and the Gift-of-Life donor program (Philadelphia, PA) for their assistance with heart tissue procurement.
Funding Sources These studies were supported by funding from GlaxoSmithKline, Inc. through an industry-academic alliance (ADDI) with the University of Pennsylvania School of Medicine (Penn) and by funding from the National Institutes of Health, Bethesda, MD (AG17022 to K.B.M.).
Conflict of Interest Disclosures Michael P. Quaile, PhD, Stephen A. Douglas, PhD and Carie L. Kimbrough, MPH currently are and/or were employees of GlaxoSmithKline.
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


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The two, Marco Rubio and Ted Cruz, have good changes to catch up with Donald Trump in the GOP nomination race, but the discrepancy between them when it comes to future plans for the country is too big, says Daily Journal, especially when the talks are about the immigration issue.
The issue was discussed ever since 2013
It looks like the Gang of Eight comprehensive immigration reform bill is causing all this friction between Marco Rubio and Cruz. According to the same source, the bill passed the Senate after a series of votes in June, 2013 and Democrats, who controlled the Senate at the time, supported the bill, while most Republicans opposed it.
There were four Republicans in the same boat with the Democrats: Rubio, John McCain, Lindsey Graham, and Jeff Flake, and their plan was to ruin almost all GOP amendments.
Marco Rubio rejected Senator Grassley's proposal
Republican Sen. Charles Grassley proposed that legalization of illegal immigrants in the United States to take effect after the administration could prove it had maintained "effective control" of the borders for six months. No surprise that Cruz supported the bill, while Marco Rubio rejected the Grassley amendment.
Sen. John Thune wanted that an old idea, 350 miles of fencing along the U.S. border, should be done before legalization could commence. He also claimed that 700 miles of such fencing is necessary before illegal immigrants' legal status could be made permanent, says Daily Journal. Of course, Marco Rubio disproved the bill. His fellow Cuban rival wanted the Thune amendment to pass.
The two had another proposal to fight about. Sen. David Vitter wanted a biometric visa identity system first ordered by Congress in 1996 to be "fully implemented at every land, sea, and airport of entry" into the United States. Struggling to ensure immigrants some rights, Marco Rubio rejected the bill.
"The eight met in private before each committee hearing, hashing out which amendments they would support and which oppose as a united coalition. Senate aides said amendments were rejected if either side felt they would shatter the deal.", the Washington Post reported in May, 2013.
A Republican reached an agreement with the Democrats
The Rubio-Democrats agreement wasn't secret for too long. At a Judiciary Committee, Sen. Charles Schumer left his microphone on and he was heared saying "Do our Republicans have a pass on this one, if they want?". Rubio wasn't present at that meeting, but he was part of the Gang agreement to kill GOP amendments, several of which were from Cruz, who was on the committee, claims the same source.
"The bottom line is there isn't that big a difference between (Cruz) and I on how to approach immigration," Rubio told CBS News recently. This statement comes in quite contradiction with facts. But Rubio has since 2013 distanced himself from the Gang bill, saying that the immigration issue cannot be resolved by one giant bill, and that his position on immigration is similar to Cruz's, according to Daily Journal.


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The next Windows Phone 7 experience comes from Samsung in the form of their recently announced Omnia W I8530. With the likes of the Nokia's Lumia 800 and the possible under Rs.20,000, Lumia 710, the competition is getting quite fierce. The Omnia range has been relatively inactive for quite some time, since Samsung has been focusing on its Galaxy series, it seems. But with the W, things could be looking better for the WP7 fans, especially with the rather reasonable price tag attached. Here's a closer look.
Form Factor
If compared to some of the recent launches from the Korean company, the Omnia W seems rather out of place. In terms of aesthetics, it's quite sound, but going by looks alone, the handset is quite plain. A singular 'Home' button resides at the bottom of the 3.7-inch Super AMOLED display and bears the Microsoft logo. On either side of this button are touch sensitive keys for 'Return' and Bing Search options. A micro USB port is positioned at the bottom and a standard 3.5mm handsfree socket is located at the top of the handset.
Not the best looking handset from the company
This is, as of now, one of the few WP7 handsets that isn't sealed right as the rear panel can be removed completely to slip in a SIM card (hot swap) or reboot the handset by removing the 1500mAh battery. It's a pity Microsoft has been taking lessons from Apple and decided that we don't need microSD cards, just the internal storage of 8GB is good enough. This is one of the few disappointments with the new OS.
Features and Performance
There's nothing more we can say about the UI than we have already in other reviews on WP7 Mango handsets like the HTC Radar, for example. To give you a quick run through, though – WP7 uses a 'Tile' system for what Microsoft calls the Metro interface. It's simplistic and extremely easy to navigate and use. With the help of a 1.4GHz Scorpion processor the Omnia W is able to optimize usage to a great extent making the UI smooth, responsive and fast. One minor issue could be that the listing of apps in the main menu is in alphabetical order and there's no room for customization or categorically listing apps. Games automatically show up under the Xbox Live games tab. There are a few colour options to choose from in the Theme section and you can opt to keep the background White or switch to Black. Go with Black, as it does help boost your battery life a little bit.
The simple but smooth WP7 UI
Tiles on the Home Page can be moved around and can be added or removed. The People section or contacts is very well designed and merges your social networking with contacts in a simplistic and user friendly manner. Except for a few "Freezing" issues that occurred from time to time (something we haven't faced in any other WP7 handsets) the Omnia W functioned smoothly. It scored 47.93 Mflops in a Linpak benchmarking test, which is quite impressive. Typing, voice clarity and screen rotation were a non-issue. The display however, was quite hard to use in bright sun-lit conditions. Even with the colours and brightness turned up, reading messages, while outdoors wasn't an easy task.
The most annoying aspect of using any WP7 device is Zune. Like iTunes, you need the Zune PC software to transfer media back and forth to a WP7 device. To make matters worse, while Samsung has a reputation of including multiple codecs into their Android and Bada devices for video playback, WP7 does not allow it. This means you'll have to either convert files to a WP7 friendly format for the Omnia W or suffer the dreadfully slow transfer speed as the software converts your files to an acceptable format for the player to read.
Buttons and 3.5mm handsfree socket
What the Omnia W lacks is enhancement features of the music players. There are no presets, as such to make any adjustments to audio output. On its own, the Omnia W offers fairly decent audio quality, but the decibel level is a little low when compared to some of the other WP7 devices available. Another disappointment! The FM radio worked out quite well and was able to get pretty decent reception in most locations. Overall, the Omnia W's media prowess could have been better and does not live up to the standard that Samsung has set for itself.
The Omnia W is a 3G handset with support for EDGE/GPRS Wi-Fi and DLNA support as well via Samsung's AllShare app that's preloaded. Bluetooth with A2DP is also present, but of course sharing pictures or videos via this medium is not on the cards. You can upload it to your Microsoft Sky Drive account, send it via email or share it on Facebook, Twitter or WhatsApp, PhotoBucket, Picasa, but that's it. Internet Explorer for the mobile is truly a well-designed browser and is quite capable of providing you with a rich browsing experience. Although we seemed to have a few issues with setting up our personal Gmail accounts on the device, our work accounts that are also Google-based seemed to work without a hitch. Social Networking integration is quite solid and embedded quite well into the various relevant aspects of the handset.
Samsung Apps best designed for the handset
Bing Maps is pre-loaded for your GPS needs, but you could opt for other third party apps from the Market Place. Samsung has also pre-selected a few free apps that the company believes could help provide you with a better experience with the handset. The Omnia W also features a forward-facing camera (VGA) for video calling.
Misc. Features
Samsung has thrown in quite a few extras that come pre-loaded onto the handset like MiniDiary that lets you store notes with locations, add voice recordings, photos and even create drawings etc. to save for later. The Daily Briefing app keeps you updated with the latest weather report, news via Yahoo! News, Currency rates via Yahoo! Finance and even Stock market rates. An RSS reader is also provided as well.
A few fun photo apps thrown in au gratis
The Omnia W is equipped with a 5 Megapixel autofocus camera with an LED flash. It features settings like White Balance, ISO settings and Macro mode. For the more fun features, Samsung has pre-loaded a couple of camera apps like Photo Studio that comes with all kinds of goodies like Lomoshot, auto-stitch Panorama etc. and a separate app called FunShot that has some effects you can use for capturing images. Image quality in general was just ok. Colours did seem to be a little dull in indoor lighting and slightly grainy with a few artifacts here and there. Outdoor pictures were much better, but the dark tone still seemed to persist.
In our stand-alone battery drain test, we switched off all connections and ran a video back to back till the battery went dead. We clocked in 6 hours and 10 minutes, which is average. In our tech2 Loop Test, we managed to get one full loop, which consisted of two hours of video, audio and audio streaming via 3G and 1.5 hours of talk time totaling up to 7 and a half hours of non-stop usage. We were barely able to get more than 10 minutes out of the next loop. Real time usage provided us with just a about a full day's use with mails, messages, calls and some audio thrown in. Not really what we expected.
Samsung Apps best designed for the handset
The Bottom Line
The Omnia W is the cheapest Windows Phone 7 right now and is available for a price of Rs.19,990 (MOP). That may seem like a great price for a handset with specs like these, however taking overall functionality into account, we were not impressed and you wouldn't be missing too much by opting for another Windows Phone 7 device, right now even if it cost you a little more.
Publish date: December 5, 2011 10:03 am| Modified date: December 18, 2013 9:05 pm
5 megapixel, Metro UI, Microsoft Windows Phone 7, Samsung Omnia W I8350, Samsung Omnia W India Price, Samsung Omnia W Launch, Samsung Omnia W price in India, Samsung Omnia W Release date, Samsung Omnia W Review, Samsung Omnia W Windows Phone 7, Smartphones, Touchscreen, Windows Phone 7 Mango, WP7
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Remote control light bulbs are a handy addition to Belkin's WeMo smart home ecosystem, but there's work to be done.
As our houses fill up with smart gadgets, the race is on to tie everything together into an integrated smart home. There are several impressive smart home systems on offer if your budget will stretch to custom installation, but if you're looking to do it yourself then Belkin's off-the-shelf WeMo ecosystem is leading the way.
The WeMo family
You'll also find smart light bulbs from the likes of Philips and LIFX, but the advantage of Belkin's bulbs is that they interact with a wide range of other Belkin smart devices. Initially Belkin released "smart switches" – internet-enabled power adaptors which let you turn any electrical device on and off using the WeMo app on an Apple or Android gadget. The app even works over mobile broadband when you're away from home.
Building on this Belkin introduced smart light switches, motion detectors and webcams which you can use to turn on power adaptors, generate alerts or trigger other events. There's also a WeMo baby monitor, coffee pot and slow cooker, along with the WeMo Maker kit (yet to come to Australia) which lets you wire up electrical devices like garage doors.
You can set timers or use motion detectors to trigger events such as turning on power adaptors, but the icing on the cake is WeMo's integration with the powerful If This Then That service which lets your smart devices interact with web services. At this point your smart home can actually start thinking for itself, such as automatically turning on your front porch light when you're close to home or switching on your electric blanket when a cold evening is forecast.
Light 'em up
This all sounds great in theory, but in practice the WeMo smart bulbs are a little underwhelming if you've spent time with competitors.
Belkin's $169.95 WeMo LED Lighting Starter Kit comes with two bulbs and the WeMo Link adaptor which plugs into a power socket and links the bulbs to your home Wi-Fi network. The WeMo Link supports up to 50 WeMo smart bulbs and you can buy extra bulbs for $49.95 each – a considerable investment compared to cheap dumb LED bulbs.
WeMo bulbs are available with screw or bayonet fittings and they're only slightly larger than traditional incandescent bulbs (unlike the bulky LIFX bulbs) so they should fit in most places. The WeMo LED bulbs offer 800 lumens brightness, roughly the equivalent of a traditional 60 watt bulb, so they're brighter than early 600 lumen Philips Hue bulbs but not as bright as the 1000 lumen LIFX bulbs.
It's important to note that, unlike the LIFX and Philips Hue bulbs, Belkin's WeMo bulbs can't change colour. You're stuck with warm white at around 3000K. This is fine if you want them to blend in with traditional bulbs but it's frustrating if you're in need of different colours and temperatures. For example, you might want 5600K "daylight" white for working on craft projects or various colours when you're trying to set the mood.
Put to the test
Whenever I test WeMo gear I have to fight with the app before it recognises new components and these smart light bulbs were no exception. Once they're finally up and running the bulbs appear in your list of devices and you can group them together to control several in unison (but you lose individual control).
Apart from switching the bulbs on and off, the app also lets you adjust the brightness. The idea of dimming the lights without getting off the couch sounds great, but reaching for your phone every time you want to adjust the light becomes annoying – especially for the people you live with who might not be as excited about smart lights as you are. Once you install these bulbs you can't use the dimmer knob on the wall. You can use the wall switch to turn the bulbs on and off, but when the wall switch is off you can't turn the bulb back on with the app.
Unfortunately the WeMo app doesn't offer the same level of granular control as you find with other smart light bulbs. It's difficult to be precise with the onscreen dimming slider and the lights don't adjust in real time, you need to wait a few seconds. You can't create pre-sets such as 30 per cent brightness in the lounge room when watching television at night, you need to mess about with the slider every time. The novelty might wear off quickly.
Working together
Of course WeMo's strength is the ecosystem, but there are still limitations which might prevent you bending the system to your will. One frustration is that we're still waiting on IFTTT to support WeMo bulbs (this should come soon). Another frustration is that you can't integrate dimming features into some smart events.
If you set WeMo lights on a timer you can control their brightness when they wake and how long they take to fade in and out. The app also lets you set sleep timers, so they fade out after a certain time. Unfortunately you're not offered the same level of control when relying on a motion detector to trigger the lights.
For example, I wanted to link the WeMo bulb outside my bathroom to a WeMo motion sensor and create a rule to turn on a dim light at night when someone steps out of their bedroom to go to the toilet. Unfortunately in this scenario you can't specify how bright the bulb shines, it automatically jumps to full brightness even if you left it down low before you switched it off. It seems like a simple enough request. Whether or not this shortcoming bothers you depends on what you want from your smart light bulbs.
So what's the verdict?
It's great to see Belkin add smart lights to the WeMo family but, to be worth the expense, a smart ecosystem needs to be worth more than the sum of its parts. If you only want to dim the lights without getting off the couch then, once the novelty wears off, you might want your dumb bulbs back.
Most people will need to find a better use for smart bulbs to justify the expense, such as creating the impression of activities when you're away from home or automating regular activities. The lack of IFTTT support and colour variations might thwart your plans, so think long and hard about exactly what you want from smart light bulbs before making the leap.


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Satin Ribbon Soaking Up Grease
Decorating By Julie5 Updated 4 Oct 2010 , 1:22pm by pastrychef101
Anyone have any ideas about using satin ribbon and it showing grease from your buttercream through it? I know that this has probably been posted a few hundred times and answered so I apologize in advance....
I think I heard somewhere you could soak it in water? Or make a backing of some kind, I'm not sure...
I just put a strip of waxed paper behind it (cut to the same size so it doesn't show, of course).
I cut a piece of parchament paper and place it behind the ribbon. It usually works great, but sometimes the top of the ribbon still soaks up a little grease. It typically isn't too noticeable.
I tried greasing the ribbon a couple of months ago. It looked good up until the point when the AC went out in the venue. It was 90 degrees inside, and the ribbon got really wet from the cake sweating.
Quote by @%username% on %date%


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If you're planning a long-haul trip for 10 or more people or a European trip for 20 or more, our dedicated Group Travel Department can help you book group airline tickets, whatever your requirements. We specialise in educational and corporate trips to key European cities and long haul group flights, tours and hotel accommodation to any destination beyond Europe.
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All the loveable characters are back - Alex the lion, Marty the zebra, Melman the giraffe and Gloria the hippo, even King Julien, Maurice and the penguins-in "Madagascar: The Crate Escape." The New Yorkers are once again bound for home on an old crashed plane that the penguins have repaired-sort of. Once airborne, the rattletrap nosedives in Africa on a wildlife reserve, where our zoo-raised crew encounter species of their own kind for the very first time. While re-connecting to their roots, the four quickly discover the differences between the concrete jungle and the African plains. Despite long-lost relatives, romantic rivals and scheming hunters-along with some "crack-a-lacking" times and comic misadventures-Africa seems like a great place.but is it better than their Central Park home?
Madagascar: Escape 2 Africa (cert 12) is at cinemas everywhere from December 5. To see more on this "safari-tastic" film and for cool downloads, games and buddy icons visit www.madagascar-themovie.co.uk
Your prize includes a pair of tickets to the UK premiere of Madagascar: Escape 2 Africa on November 23 in London's Leicester Square.
Based on the upcoming feature film from DreamWorks Animation, the four famous zoo animals and their crew take you on a whole new journey in the Madagascar: Escape 2 Africa video game.
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Terms & Conditions
1) The winner will receive the following prize: two tickets to the UK premiere of Madagascar 2 Escape to Africa on November 23 2008 at 4pm.
2) Prizes are non-changeable, non-transferable and there is no cash alternative.
3) Travel expenses are not included as part of the prize.
4) Competition closes at 10:00am on November 21 and the winner will be selected at random.
5) If for any reason you are not able to attend we are unable to exchange this prize.


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Pet Sitter in Newport Beach
I am 27, female, and single. I cannot have a pet where I live so I would love to help you out. During the day I work as a cardiac sonographer so I am available nights and weekends. I can walk your dog or take care of them if you need to go out of town. Let me know what you need and we can work something out! References available.
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Because cards and keys are all you really need.
Silk Pajamas for a Super Luxe Sleep
Some days you can't be tied down to a big tote bag. These keychain-zip pouch combos help you keep just the essentials at hand, and it doesn't hurt that they're also pretty cute. Just the right size for storing credit cards and an ID, shop these now and you'll be ready for your next quick errand or night out.More
This small coin purse packs a big punch in bright yellow leather. It's decked with the same studs on Minkoff's newest handbag designs, and has just enough room for cards and cash.
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Bonding or veneers or whitening? Tooth discolouration/porous teeth. (photos)
Hi I have a good set of healthy teeth but have been having trouble with staining of my front four teeth. I used to use alot of harsh whitening toothpastes and i think they have caused damage and porous teeth. I have them cleaned regulatly and they are fine for around 2-3 weeks before becoming stained again. The front tooth looks grey in photos. I have never experienced any trauma to this tooth so i am confused! My dentist did try 'etching' to smooth the teeth, could this have caused this?


text: The Cavanal Hill Funds announced today that its funds have once again been honored by the Thomson Reuters Awards of Excellence with Lipper Fund Awards, as well as three number one Lipper rankings. The Lipper Fund Awards are given out annually to recognize funds that have excelled in delivering strong risk-adjusted performance, relative to their peers. Cavanal Hill's Intermediate Bond Fund, Institutional (AIFBX) received Lipper Fund Awards for both the three-year 1 and five-year 2 periods. This is the second year that the fund, managed by Mike Maurer, senior vice president and senior fixed income portfolio manager, has received the honor. In 2013 the Intermediate Bond Fund, Institutional (AIFBX) was the recipient of the Lipper Fund Award for outstanding performance over three-year time period 3. The fund ranked number one out of 109 funds in the short-intermediate investment grade debt category for the three-year period ending Nov. 30, 2013. It also ranked number one out of 98 funds in the short-intermediate investment grade debt category for the five-year period ending Nov. 30, 2013. This is not the only fund Maurer manages that has received the prestigious Fund Award. In 2012, the Short-Term Income Fund, Institutional (AISTX) also received the Lipper Fund Award for outstanding performance over the three-year time period 4. Maurer said his team exercises discipline in order to identify and maximize the best long-term investments. "We are committed to finding the top opportunities available in the market by searching for securities that enhance the fund's returns without compromising its risk profile," said Maurer. "In this very low yield environment, that takes tremendous discipline." Brian Henderson, president of Cavanal Hill, said he's proud of Maurer and his team for these fund awards. "It's unique to have one fund manager receive four Lipper Fund Awards in such a short period of time, and we think that's a direct reflection of the quality work we do at Cavanal Hill," said Henderson.


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Inside 2 pages of the 1990 CNA diary. Mandela wrote on 1 January 1990
Nelson Mandela Centre of Memory
Title: (Image 4)
Description: Inside 2 pages of the 1990 CNA diary. Mandela wrote on 1 January 1990
Transcript: Visited by Rhadi and JN Singh who generously left behind a 1988/9 Race Relations Survey and 1990 CNA diary. Today is also JN's 68th birthday. Although his once handsome face carries clear signs of old age, he still looks impressive and well spoken. Rhadi now carries a bit of spare flesh around her bones, and thus looks broader and shorter than expected. But she still looked beautiful and innocent. After their departure Warrant Officer Swart remarks that of all the people who had visited this place during the last 12 months he liked this couple the best. Where others regarded him as Government official, these two accepted him as one of them.
Reference code: 4
Extent and Medium: Inside pages; 1 image
Immediate source of acquisition or transfer: Deposited by Nelson Mandela


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I fell off my regimen for about a week, it all started with a binge day on all the stuff I never eat. I literally smashed one slice shy of a whole pizza. Felt like crap.. I have no 'I'm full" trigger. The Good news is that there is always time to hit the reset button! Any other food addicts out there? Food logging and structure is the key to overcoming this issue!
Food logging definitely helps a lot. And cheat meals every once in a while helps too :-)
Drink a lot of water. Sometimes we eat even if we aren't hungry and it's because we are bored. I keep myself busy and try to be productive so I don't think about food all the time :) if you had a bad meal don't overthink and make sure your next one is healthy
I had been on the same point as you are. I am happy that I am back again and I am happy for you as well.