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Circlet crowns are among the simplest of all crowns and are perfect for creating medieval or fantasy-themed costumes, such as those inspired by elves and fairies. Circlet crowns can be made of expensive and finely-worked materials such as gold or silver but a crown made of flowers is traditional, pretty and inexpensive to make and is at least as authentic as those made of more complicated designs and precious metals.
Things You'll Need
- Wire coathangers
- Florists tape
- Fresh or artificial flowers
Untwist wire coat hangers, allowing one coat hanger per crown.
Bend each coat hanger into a circle that will fit snugly onto the head of the wearer. Twist the ends around the main circlet so they do not stick out and wrap with florists' tape so there are no sharp ends. Repeat until you have made a sufficient number of circlet crowns.
Separate flowers into small bunches. Use five or six stems for small flowers or three to four stems for large flowers. Hold a bunch at a time against the wire of the circlet and tape in place with florists tape at the stems. Add another bunch of flowers. The heads of that bunch should overlap and cover the taped stems of the first bunch. Tape in place at the stems. Continue until you've covered the whole circlet in flowers. Repeat until you have covered all the circlet crowns you are making with flowers.
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- Photo Credit Ablestock.com/AbleStock.com/Getty Images
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Near Beach with Park Like Community!
Condo in quiet, gated community beautifully remodeled unit with new paint, carpet, kitchen cabinets, tile floors, granite counters and appliances. Wood burning fire place! Complex is loaded with amenities: racquetball, tennis, volleyball, basketball, workout room, pool and spa, Carwash facility with vacuum and walking/hiking trails. Please ask for Rob when you call.
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subset: commoncrawl


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An imperious Novak Djokovic proved unstoppable and courageous Juan Martin Del Potro indomitable as both claimed straight-sets victories yesterday to set up a Wimbledon semi-final clash.
Top seed Djokovic reeled off his fifth successive three-set victory although his quarter-final against Czech seventh seed Tomas Berdych was harder than the 7-6 (7/5), 6-4, 6-3 scoreline suggested.
Untroubled so far as he targets a second Wimbledon title, the clinical Serb had to find his best tennis to subdue Berdych who beat Djokovic in their only previous grasscourt meeting.
"It was a very close match, and that's what I expected," said Djokovic, who lost to Del Potro in an Olympic bronze-medal match at Wimbledon last year. "Tomas is a very powerful player. We went toe-to-toe in the first set."
Del Potro looked down and out after five points against Ferrer when his already-bandaged left knee crumpled as he tumbled while chasing a wide ball behind the baseline.
Grimacing in pain, the eighth seed climbed up from the turf, however, and after treatment and a pain-killing tablet produced a sledgehammer-like performance to beat fourth seed David Ferrer 6-2, 6-4, 7-6 (7/5).
Such was the venom in his murderous forehand that any injury concerns were put aside as he struck 22 winners on that flank alone, including a screamer on match point.
"It was the same thing as my third-round match," said Del Potro, who first injured his knee on Saturday. "I was very close [to pulling out] because I felt a lot of pain in the beginning of the match, it was exactly the same like I did before. I twisted my knee once again and the doctor gave me some magic pills and I could finish the match."
Del Potro's medical team will work overtime to patch him up for tomorrow's semi.
Djokovic has looked in almost total control so far and even when the dangerous Berdych began to threaten, he found an extra gear to reach his 13th consecutive grand slam semi-final.
"You have to play really on the limit, playing really great to have a chance to beat him," Berdych said. "That was not my case today."


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All Guns
Gun Parts
|Seller's Description
This is 1970"s era combination gun made by Tikka in Finland and imported by Ithaca. It is stamped 12-70 indicating it is chambered for 2 ¾ inch shells. The blued barrels are 24 inches long and made with Bofors steel. The 12 gauge is mounted on top and has a solid rib, with adjustable rear and dovetailed front sights, side mounted selector switch, and a hammer extension. The tip of the exposed hammer is missing. The bores are excellent and has a choke tube marked X. A Buehler base and rings have been installed and is included. The Monte Carlo shoulder stock and forearm are checkered. The LOP is 14 inches over a Pachmyer pad. Both the blue and the wood are excellent with only a few very light handling marks. This is a high grade firearm with matching numbers on the receiver, barrel, and forearm. All of our auctions are offered with NO RESERVE.
We require that you contact us within 72 hours of auction close to confirm the purchase and your method of payment (see options below). If you will be unable to do this, for any reason, please let us know before bidding.
The Hunter's Den is a working gun store and all firearms are for sale in our shop until they receive their first bid at auction. We reserve the right to stop auctions early, and remove from auction, if they are sold in our shop prior to receiving bids. Once an item receives a bid it is taken from the rack and held for the winning bidder.
If you have any questions please ask them before bidding. We check the email often and will respond as soon as possible. Take a few minutes to check out our other auctions. You can contact us at: THE HUNTERS DEN
New Castle, Va. 24127
This is 1970"s era combination gun made by Tikka in Finland and imported by Ithaca. It is stamped 12-70 indicating it is chambered for 2 ¾ inch shells. The b
|Payment and Shipping Instructions:
Payment Options: We accept Visa, Mastercard, and USPS Money Orders. There is NO CHARGE for credit card use. All other Money Orders, Personal and Business Checks will be accepted at the option of the seller and will be held until cleared by our bank. Payment must be received within seven (7) days of auction end or the item will be re-listed. Virginia residents must add 5% sales tax. Please do not bid if you do not intend to pay for and complete the auction.
Safety Notice: Buyer is solely responsible for determining that a used gun is safe to shoot. The firearms offered have not been test fired or disassembled but have been given a visual inspection only for auction purposes. It is recommended that every used firearm be inspected by a qualified gunsmith before firing. By bidding the buyer agrees to hold seller harmless against damages, injury, or death caused by defective merchandise.
State and Federal Laws: An FFL or C&R is required for firearm purchase. Buyer is responsible for securing an FFL dealer to furnish a copy of his/her FFL or C&R copy to the seller. A C&R copy will be accepted for C&R qualified firearms only. Please be aware of your states firearms and ammunition laws before bidding on an item. We must have proof of age when purchasing ammunition. A faxed or mailed copy of your valid drivers license is acceptable.
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Classic feeder for adult chickens and other birds, with 14 feeding holes (7 on each side). Covered top helps keep debris out of the feed, while individual holes minimize waste. Top slides off for easy filling and cleaning. Made of heavy-gauge galvanized steel for years of service, with rolled edges for safety. Measures 12.5 inch long by 3.875 inch wide by 2.75 inch high.


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CBS News in Richmond, Virginia, Covers Lamb of God Vocalist Randy Blythe's Arrest for Manslaughter
As reported right here last night, Lamb of God frontman Randy Blythe (pictured left, center) was arrested yesterday in the Czech Republic and charged with manslaughter due to an incident dating back to 2010. Now CBS News in his hometown, Richmond, Virginia, has issued a report on the story. You can watch the report at WTVR.com.
Lamb Of God's publicist, Adrenaline PR, has stated that Blythe was "wrongly accused, lawyers are dealing with it, and we expect him to be fully exonerated." As for the band, they recented posted a simple message on Twitter: #FreeRandyBlythe
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disgraceful discourse on the anti-dengue drug
i get asked why i bother to blog again and again on ActRx TriAct when no one seems to be reading, much less agreeing; mostly, the comments only echo, insist on, what kill-the-cocktail proponents feed an unthinking mediocre media.
meron naman akong readers, heh, or so my site stats tell me, and dr. stuart and i have been receiving email thanking us for the posts and the research and wishing that mainstream media would pick them up, publish them as well, so the public may know. yeah, we wish.
but even if i had just a handful of readers, or even if no one agreed with the sentiments expressed herein, i would continue to blog, if only for the record. i would continue to share my thoughts and reactions on an issue such as this that has national and worldwide significance. dengue is a global public health concern, after all, and let it not be said, now and in the future, that pinoys, one and all, sat back and allowed the killing of a promising anti-dengue cocktail without question or resistance.
which is also to say that it is dismaying, nay, disturbing, nay, scandalizing! that the public discourse is so one-sided. except for dr. tony leachon, speaking for the philippine college of physicians and the philippine medical association, and dr. sylvia claudio in her online column – both pro-garin, it would seem — we are not hearing any dissent from the medical community. no doubt there are dissenters, but unfortunately they choose to not make public their informed opinions (along with their identities), they choose to not engage in, contribute to, an exchange of expert views, whether for or against. ask them why, and they'll invoke the politics, the dirty politics; they'd rather not get involved.
but surely the good doctors know that their silence has political repercussions, too, giving the impression that they're all okay (as in, all right) with acting DOH sec garin's godawful decision to stop the ActRx TriAct clinical trials?
yeah, the devil is in the politics.* and on this blog, we dare confront that devil.
Dr. Stuart: I received anonymous emails with links to articles on the position of the Philippine Medical Association (PMA) and the Philippine College of Physicians (PCP), in support of the cancellation of the expanded clinical trials of the anti-dengue drug, ActRx TriAct. One was accompanied by a link to the WMA (World Medical Association)'s Declaration of Helsinki: Ethical Principles for Medical Research Involving Human Subjects.
What the media reported on the PMA POSITION was a nitpicking criticism, full of text extracts from Dr. Calimag, without even the briefest elucidation on the censured design and analysis flaws.
In contrast, The WMA DECLARATION OF HELSINKI: ETHICAL PRINCIPLES FOR MEDICAL REASEARCH INVOLVING HUMAN SUBJECTS was an interesting read. I wondered which of the 37 articles the ActRx TriAct study violated. I likewise wondered if maybe it was sent in support of the ActRx TriAct study.
The last article was especially compelling: Unproven Interventions in Clinical Practice — "…where proven interventions do not exist or other known interventions have been ineffective, the physician, after seeking expert advice, with informed consent from the patient or a legal representative, MAY USE AN UNPROVEN INTERVENTION IF IN THE PHYSICAN'S JUDGMENT IT OFFERS HOPE OF SAVING LIFE, RE-ESTABLISHING HEALTH OR ALLEVIATING SUFFERING." Compelling — because it advocates the use of the medicine for compassionate use.
I don't want to belabor the fact. The components of the ActRx TriAct anti-dengue therapy are old drugs, being repurposed or repositioned for new uses. Repositioning or repurposing drugs is one way of significantly shortening the process of drug studies and trials. Yet, criticisms continue to express incredulity on why the ActRx TriAct therapy did not take the usual 12 to 14 years of new drug development.
The PCP POSITION also slammed the people behind the clinical trial for including some children as subjects. Why are doctors so horrified or against testing the efficacy of the treatment on children? Ladies and gentlemen, it is the children who are most vulnerable, it is in the children's sector where most fatalities are found in a 2011 study. From January to September, there were a total of 86,662 cases, with 65,000 (74%) occurring in all confirmed cases. 36% of these occurred in children aged 1-9 years, resulting in 265 deaths, representing 60% of deaths due to dengue in 2011.
CRAP? There was also a public status on facebook posted by Dr. Claudio, that "the science supporting Ona's anti-dengue miracle drug is crap." In the course of public discourse, that the best argument a doctor in her position can offer is that the study is "crap," is sad, unprofessional, disreputable, and downright juvenile. The study is crap!—and that's it? We take her word for it? We deserve better than that. She should not have called a study "crap" based on reports she is privy to but she is not willing to divulge. Such criticism is crappier than crap.
The medical voices or the guardians of truth charged with informing the public is burdened with the responsibility of providing explanatory answers, not silently agreeing to pronouncements of "crap."
We need a clear judgment and resolution on this controversial matter from a really independent scientific review board — if that is at all possible — not rantings from the bully pulpit or DOH press releases dutifully published by kowtowing media, repeating, ad nauseam, pronouncements from on high without looking deeper into or researching the issues.
GAME OVER? But is it all moot now? Has the circus left town? Dr. Ona has resigned, silenced, lips politically zipped? The pneumonia vaccine issue abandoned to die a quiet death? The anti-dengue drug vilified as crap? The study criticized as unethical, diagnostically inaccurate, no endorsements, dubious paper trails, poorly designed, flawed data analysis, blah blah blah? Were these a fagot of separate political issues—of demolition, positioning, wheeling-dealing, and a clashing of government egos—really meant to get Ona out of the picture?
Or is this partly issuing from the great disdain by many in the medical community of anything that has to do with alternative medicine? Remember, many of the medicines that grace the pharmaceutical landscape are plant derived, and many more are waiting to be discovered, many a lot safer, without the toxicities of synthetic pharmaceuticals.
In the ActRx TriAct study of 290 patients — 145 received the drug treatment, 145 did not — there were no deaths in both groups of patients. The PCP concludes that because no one died in the 145 who didn't take the drug, the "experimental drug added nothing in preventing deaths." This is a valid scientific conclusion? Or just a position intent on seeing the cup half empty rather than half full.
In different studies, dengue deaths ranged from one for every 185 to 250 cases. In the ActRx TriAct study of 290 patients (145 with treatment, 145 without), taking the optimist position, the absence of death might suggest the benefit of prevention of at least one fatality.
Calimag also said: "the lack of adverse events in a small sample size is not conclusive evidence of the absence of harm." Taking the optimist position, the absence of adverse effects might suggest the absence of toxicity — three drug components that have already undergone extensive toxicity evaluation — and the absence of deaths, albeit a small sample size, should support further expanded study and testing, especially in the many provinces that have attained malaria-free status.
THE CAT IS OUT OF THE BAG. Even here in the boondocks, a local alternative healer has asked me about it. In places like these, what is to keep the local healers from accessing the separate components of the drugs for the occasional desperate families seeking any possible treatment for dengue stricken family members?
Is the study dead? I hope not—because the anti-dengue drug treatment has NOT been debunked. And calling it "crap" doesn't kill it. Perhaps, dissenting voices from the medical community might still surface and dare to disagree with the powers that be, provide a badly needed and audible point of view.
If it is a bad study, tweaked or falsified, or in the end, proven as crap, I'll be glad to help pull the trigger and kill it. BUT if the potential to save lives still exists, the testing and expanded use must be allowed to go forward. This year, from January to September 2014, there have been about 60,000 reported cases of dengue in the Philippines, with about 242 deaths (4 deaths for every 1,000 cases). These numbers cry out.
What a shame if in the end ActRx TriAct is taken elsewhere, and the drug is shown to work.
my pet theory is, the demolition job on ona and ActRx TriAct is in aid of that dengue vaccine for which a huge pharmaceutical company has spent $1.5 B on research and development, soon to be out in the market. as i've blogged before, we could use both ActRx TriAct AND a dengue vaccine. dr. stuart tells of the vaccine's limitations here.
and if you've read this far, good for you, i saved some juicy tidbits for last. over the holidays, different grapevines were buzzing with anti-garin stories: how she wants the post so badly, sorry na lang si ona, and how she's not even qualified for such a high post — she's more a politician daw than a physician, much less, a scientist (check out her wikipedia profile).
but the juiciest story, a sweet stab of sarcasm from ona himself, came via inquirer's christmas day report, Ona: Loss of Aquino's confidence prompted me to quit
When asked about his relationship with the acting health secretary, Ona said he thought it was "very ideal.''
… "My personal things were brought to my house even before I officially announced my resignation and there's only one person in DOH who could make such order,'' Ona said.
whew, what a game she plays. this is the same aquino-appointed acting DOH sec who brazenly disobeyed the quarantine rules imposed on families of travellers from ebola-stricken countries, the very same one, still unmasked, whom our senators welcomed to their august halls with beso-besos to boot.
the anarchy proceeds apace. in the highest places yet.
* "The devil is in the politics" is how i ended the book Revolutionary Routes: Five stories of incarceration, exile, murder, and betrayal in Tayabas province, 1891-1980 (2011)
10 Responses to disgraceful discourse on the anti-dengue drug
December 30, 2014 at 11:45 am
Best wishes to you, Angela, and to everyone.
December 30, 2014 at 6:43 pm
I'm glad to know there are still some people who think about the welfare of the masses (as opposed to politics for self-interest). I wish you and your family a safe and a fruitful New Year.
I believe that we Filipinos deserve better. Better health, better environment, better government, better economy.
January 6, 2015 at 4:28 pm
I am one of the co-investigators of study..
In behalf of the medical research team, we would like to express our gratitude in your support to our cause!
The reason why we, as medical practitioners and researchers, have not gone out to the press and release our statements is because first of all, we do not want to involve ourselves in politics. Secondly, we have not received any formal complaint against us or the study. All issues being thrown at us are all allegations and speculations.
Last November 30, the DOH has released a statement with regards to the suspension of the DOH Department Order 2014-0161 regarding the implementation of the Clinical Trial on Dengue. We got hold of the said statement and we have answered everything point by point. I will be sharing to you a copy of our response to the DOH statement.
1. Berberine was used in the studies even without specific and definitive scientific bases for the researchers' claims that in can cure malaria or dengue
In a study done by Jia, F., et al, entitled Identification of palmatine as an inhibitor of West Nile virus published 2010 in Arch Virol, it was found out that palmatine, which is a member of the protoberberine class isoquinoline alkaloid, was able to suppress West Nile Virus without detectable cytotoxicity. The study has shown that the compound is able to "block the activity of NS3 protease which flaviviruses like the West Nile Virus and Dengue Virus encode."
West Nile Virus is member of the virus family Flaviviridae wherein the dengue virus is also a member. It can also be noted that the article suggests that the compound "might be a potential candidate for treatment of flavivirus infections (including dengue)."
It is the objective of the researchers to test the hypothesis that berberine has an anti-viral effect on dengue virus.
Artemisinin Derivatives, such as artemether and artesunate, also have established effects as an anti-viral drug. In an article that was published by Efferth, et. al., in the Clinical Infectious Diseases in the US last 2008, entitled, The Antiviral Activities of Artemisinin and Artesunate, it expounded on some of the different anti-viral properties of artemether and artesunate. Some of the viruses listed in the article include CMV, Herpes, HBV, HCV, even HIV-1. "The value of this compound is not limited to the treatment of malaria, and a wealth of studies have demonstrating the activity of artemisinin and its derivatives against…various viral diseases."
With this premise, the researchers would like to study if artemisinin and its derivatives also have anti-viral properties against dengue.
In a research conducted by Sheng, et. al., which was internationally published in 1997 by the East African Medical Journal entitled "Treatment of chloroquine-resistant malaria using pyrimethamine in combination with berberine, tetracycline or cotrimoxazole," results showed that berberine has a greater clearing effect than the other treatment arms.
Since there is proof that berberine has anti-malarial properties, the researchers now aim to test whether berberine plus artemether, artesunate, and primaquine may be efficacious for the treatment of malaria
2. The use of artemether and artesunate is considered as "artemisinin monotherapy", which increases the prevalence of resistance to anti-malarial drug.
The ActRx Malaria study does not use an artemisinin monotherapy, rather, it utilizes a combination of artemether, artesunate, primaquine, and berberine. The purpose of the study to be able to develop a new combination of drugs that would be an available alternative treatment that the filipino malaria patients would be able to use. The use of the artemether plus artesunate, primaquine, and berberine might be the combination we are looking for to prevent the development of resistance from the "artemisinin monotherapy."
3. The combination of berberine, arthemether, and artesunate may have long-term effects that have not yet been studied adequately.
Review of literatures do not show any data that proves that the individual drugs have long-term deleterious effects.
The research team have data to show that berberine is safe for use for all ages. In a study done be Gupte, et. al. last 1971, entitled The of Berberine in Treatment of Giardiasis, a total of 137 subjects with ages ranging from 5months to 14years of age received berberine as a treatment of giardiasis, which is an intestinal parasite causing severe diarrhea.
In another study done by Zhang et. al., in 2006, Assessment of taste development in 62 newborn infants they administered berberine to assess the taste reaction of neonates 90 minutes after birth. This proves that berberine is safe for consumption even for neonates.
4. By not complying with the International Conference on Harmonization Guidelines for Good Clinical Practice, the 2012 malaria study lacks strong scientific merit and study participants were not afforded their due protection.
ALL of the studies being questioned have undergone ethical and technical review by the independent review boards of the participating institutions wherein the studies were conducted, as this is the requirement by the International Conference on Harmonization Guidelines for Good Clinical Practice.
ALL of the subjects were also afforded their due protection since all subjects were covered by a deed of legal undertaking wherein any form of complications that would be directly related to the test drugs would be the responsibility of the sponsor of the study.
ALL of the subjects, based on the International Conference on Harmonization Guidelines for Good Clinical Practice, have been given and have signed the informed consent and assent forms. The informed consent means that all subjects were informed of the study protocol and have willingly consented to become part of the study. Patients who did not sign the informed consent were not included in the study.
5. The 2013 dengue clinical study was noted by the Philippine Council for Health Research and Development (PCHRD) to have the following deficiencies:
Missing baseline characteristics of study participants;
The baseline characteristics were included in the research report handed to the members of the review board.
Lack of scientific justification for the use of artemether and artesunate for dengue treatment;
Answers from number 1
Absence of pre-clinical studies on each of the three drugs (berberine, artemether, and artesunate) as to which drug has anti-dengue properties
Each of the three drugs have already scientific bases that show possible effects in the treatment of dengue from other clinical studies. Answers can be found in number 1.
This item also seems contradictory to the updated memorandum that the PCHRD has released last December 1
6. In addition to all these, to date, ActRx TRIACT has not been registered with the FDA whether as a drug or as a food or a supplement. Thus, it has no legal basis to be present in the Philippines, especially for clinical trials.
ActRx TriAct is NOT registered as a drug or as a food or a supplement basically because it is still undergoing clinical trials to have a basis for the registration to the FDA. The Philippine FDA has approved the use of the drug for clinical research purposes only.
7. This is highly irregular and dangerous because in not following and complying with the basic protocol of scientific experiments using human subjects, the researchers are endangering the lives of the Filipino people who were given ActRx TRIACT without any accountability and transparency.
Upon review of literatures, there were NO evidence that showed that the use of these drugs are irregular and dangerous. Further review show that there are strong evidences that Artemisinin derivatives and berberine are very safe for the consumption of the general population. Examples of these are sited in number 1.
8. If something happens to those who had taken the ActRx TRIACT months or years from now, how and where do they seek legal remedy?
All subjects enrolled in the study are covered by the Deed of Legal Undertaking and Informed Consent and Assent between the subjects, the researchers, and the sponsors.
Also, let it be known that the investigators are members of Good-Standing of the Philippine College of Physicians(PCP) and of the Philippine Society for Microbiology and Infectious Diseases(PSMID). We would like to express our concern on how the societies have released a statement in the newspapers without consulting the concerned people. The joint statement by the PCP and PSMID was released in newspaper advertisements "so that the public may know", yet up to present, we have not released any letter of communication from our societies. If they were really concerned of how we have conducted our clinical trials, they should have talked to us and not the media.
There was even another statement from Dr. Leachon urging the Senate to probe the people behind the study. If Dr Leachon really believes we have done something illegal, why doesn't he himself file a case against us? Why urge the senate to probe if they know that something was wrong? And on what grounds are being charged? The Medical Research Team behind the study is ready and willing to go through any investigation and answer all accusations against us.
Again, in behalf of the research team, we would like to express our sincerest gratitude in your support of continuing medical education. Rest assured we would will continue to strive to provide our patients a better regimen for the treatment of dengue.
January 6, 2015 at 10:44 pm
Sir Dennis, thanks for coming out to clear the doubts hovering the contentious issue on the ethical and legal protocols which were followed during the research test on this anti-dengue drug. i am sure as a member of the research team you will not compromise your expertise to validate a medical break-through beyond your field of study.
January 11, 2015 at 11:26 am
Good Morning Mam. I hope you dont mind, can I get your personal email so I can send you docs and info. please send me a reply via the email provided above. Thanks.
January 17, 2015 at 9:50 am
At last more people are coming out. It looks like the medical researchers really know what they are doing. Of course, this is what I expect. Before a research proposal will be approved and allocated a budget, it has to be subjected to scrutiny by the funding agency. It turns out that PCP and PSMID is involved in politicking. Thank you Sir Dennis and Save Life.


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The perfect blend of fact and fiction seeps a bloody trail across John Matthews' LETTERS FROM A MURDERER, a book that revisits Jack the Ripper and his terrorising murder spree in the 1890's.
In this take on the infamous Ripper murders, the genius-like Jameson and hard nosed cop Argenti investigate the untimely end of a number of women of the night; those with loose morals and wanton ways who peddle their most valuable commodity for survival in pre 1900's America. Yes, that's right, the Ripper has crossed continents to slice fear into the severed arteries of the American public.
Compounding the murders is another criminal dynamic; an underworld organisation of sorts that runs girls, drugs and controls the beat cops in the broken down alleyways of New York. Not wanting the Ripper murders to get in the way of business, nor bring unwanted attention, Jameson and Argenti find themselves the target of first an assassination and then suspects in the prostitute killings.
LETTERS FROM A MURDERER captured the essence of the murderous Ripper period to perfection. Both London and New York had a real sense of place and their own unique identity. The police investigation showcased the true nature of law enforcement at the time detailing it's limitations and reliance upon personal accounts of eyewitness to bring forth justice. It's a dramatic difference to the technology used in real and fictional world crime fiction today.
For me, author John Matthews ticked all the right boxes. From the interesting and odd coupling of Jameson and Argenti, to the characterisation of peripheral prostitutes and victims. Each element was three dimensional and invoked a sense of realism which helped transport me to the time where this heinous tale of bloodshed was splashed across the headlines.
I hope readers get the opportunity to enjoy more stories to feature Jameson and Argenti, I got the impression, we're just scratching the surface of their potential.
Fans of historical crime, and crime fiction in general will get a real kick out of reading LETTERS FROM A MURDERER. Highly recommend.


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Maryland Bay Restoration Fund
October 28, 2011 by staff
Maryland Bay Restoration Fund, Maryland environmental working group is considering doubling or tripling of the state flush fee as part of efforts to restore the Chesapeake Bay.
Property owners already pay in Maryland and 30 year in a Restoration Fund of the Bay. The working group is considering a proposal to double the number in 2013 and increased to 90 and in 2015.
The restoration fund is aimed at improving plant wastewater treatment and prevention of agricultural pollutants from running into waterways that empty into the bay.
The working group met on Tuesday in Annapolis. The proposed fees color, is scheduled to be discussed at two meetings this year.
Please feel free to send if you have any questions regarding this post , you can contact on
Disclaimer: The views expressed on this site are that of the authors and not necessarily that of U.S.S.POST.


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Trius Therapeutics (TSRX) is a recent stock that our investment group has been buying. Our last buy was Sarepta Therapeutics (NASDAQ:SRPT) which is up 10% in the last 2 weeks. Biggest winners include Map Pharmaceuticals (which was eventually bought out by Allergan Inc. (NYSE:AGN) and Acadia Pharmaceuticals (NASDAQ:ACAD) which has risen 250% since our last report that can be read here.
This article will explain the bullish scenario for TSRX, both technically and fundamentally. We believe the company has big potential into 2013 and the future. The share price has been consolidating recently but we expect a big move coming in the next few weeks.
The company
TSRX is a biopharmaceutical company focused on the discovery, development and commercialization of innovative antibiotics for life-threatening infections. Novel therapeutics are always needed as bacterial resistance continues to be on the rise. Serious infections are becoming more difficult to treat causing further problems and complications. This is where TSRX comes in.
The story
TSRX produces a drug known as Torezolid, now commonly known as Tedizolid. This is an oxazolidinone drug that is used for complicated skin and skin-structure infections, including those caused by Methicillin-resistant Staphylococcus aureus (MRSA) infections. The prodrug is known as TR-701.
What is interesting is that there is only one drug that is currently approved by the FDA to combat these infections. This drug, known as Linezolid and marketed by Pfizer (NYSE:PFE) is active against streptococci, vancomycin-resistant enterococci and MRSA. Linezolid is the leading antibiotic currently, with sales of $1.35 billion in 2012. Side-effects of the drug include diarrhea (3-11% of clinical participants), headache (1-11%), nausea 3-10%, rash (2%), constipation (2%) and altered taste perception. Bone marrow suppression has been cited in long term use. Other side-effects include neuropathies, both peripheral and optic.
The picture below shows the current pipeline currently under process. Have a look here for more detailed information.
Current studies
Tedizolid is an IV and orally administered drug. It has been designed for improved potency, resistance, and spectrum of activity. The latest Phase 3 results were very positive.
Jeffrey Stein PhD, The CEO of TSRX stated recently:
"There has been a significant need for new antibiotic therapies targeting resistant bacterial infections, such as MSRA." He continues by saying "Results show that tedizolid phosphate represents a potential new therapy to treat severe skin infections with a once daily IV infusion or pill in fewer days than existing antibiotic medications."
The full study of the latest Phase III result can be read here. Both the IV and oral medication were tolerated well.
Fundamental analysis
The company is currently valued at around $396m. It has $83m cash in hand with 0 debt. The float is low at 37m shares. 28% of the float is owned by insiders. Interestingly, a high percentage of the float, currently around 10% is short. This bodes well for a short squeeze that can take the stock to new highs. There hasn't been any major selling from insiders which is bullish going forward.
Technical analysis
The future
I expect big things for TSRX into 2013 and 2014. I expect that TSRX will file for an NDA (New Drug Application) shortly and possibly a partnership in the coming months. Some bulls keep calling for a buyout. The trend in the stock is up. We own January 2014 calls and will be adding to our position over new highs.
Disclosure: I am long TSRX. I wrote this article myself, and it expresses my own opinions. I am not receiving compensation for it (other than from Seeking Alpha). I have no business relationship with any company whose stock is mentioned in this article.


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This 0install repository provides feeds for programs where the upstream authors do not provide feeds of their own. The repository is kindly hosted by the FSF, and hosts only Free software.
The contents of this repository are maintained in a GIT repository. Some packages are created by hand, others are generated automatically from Debian packages.
See 0install.net for more information about Zero Install.
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Seriously Soulful, Bristol - Bristol
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Quality, underplayed 60s and 70s soul
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The Bristol Fringe
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Celebrity Guitar String Bracelets for Charity
Rikke Gudnitz has a true passion for beauty in intention of tailoring every gown with an impeccable craftsmanship with that Old Hollywood glamor
Go Superhero With Little Capers!
Patrick is a man who places particular importance upon physical appearance, refined language, and leisurely hobbies, pursued with the appearance of nonchalance in a cult of Self
Carmen Steffens kicked off their 2010 Fall/Winter collection with a virtual fashion show and in-store event Thursday evening at their Westfield Fashion Square location in Sherman Oaks, CA. If you've never heard of this Brazilian-based trendsetting brand, go online to view the collection
"Fashions fade, style is eternal." The words of French fashion designer Yves Saint Laurent. It's a pertinent quote that is applicable to the intuitive fashion artistry found in the designs of Kao Pao Shu
"Love & Hope Ribbon" Breast Cancer Awareness Tee
Breast Cancer Awareness Purse Hanger
Gen Arts calls on its alumni, fashion industry vets, and Amber Rose to kick off LA Fashion week with a poolside celebration at the Roosevelt Hotel's Tropicana lounge in Hollywood
Nestled in Evanston on Prairie and Central you will find Chalk, a new upscale boutique catering to women who fancy basics with refined details


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on sale o size nice with skinny jeans Im really happy. Good quality and comfort. I love it. Delivery in 3 days. Highly recommended. Five stars for this product.... Please bring in size 7 I need these shoes they are gorgeous but the sizing is just to small! These socks are quite thin but do feel great and are very comfy. I would recommend this product to others Good fit, good quality, good colour choice too, these socks washed really well too, material not too thick, would recommend Love these trainers socks. Come in various shades and colours. Great value for money. I have been buying/wearing Puma socks for several years now and these are great. Love this style of sock and these fit perfectly (I'm a size 8/9 shoe) compared to other brands I have tried (including Nike and Slazenger). I wear them every day (not the same pair, obviously) and I suppose a single pair would last me around around a year before the bottoms start to wear down. They are such a reasonable price online too, highly recommend these trainer socks. Arrived on time with no problems, and fitted well Thanks I'm a size 1 Hartford ng stink disappears.These things are awesome, try them I bought these to use in my roller skates, which I use at least twice a week for three to five hours at a time - they'd started smelling really noxious. These are the perfect size to sit near to the toe of my skates so I just leave them in there whenever I don't wear them. Not only did they clear out the original stink, but they've continued to protect against any smells taking hold again. They do have a slight smell of their own which is difficult to describe (a bit like washing powder?) but totally livable, and it does dissipate from inside the shoe quite quickly after removing the ball, leaving just a nice, clean smell! The design also means that if the balls aren't being used in a shoe you can close up the air vents to contain the smell. I was not expecting these to work very effectively but have now been using them happily for months; I'm a totally satis best laptop prices I have just read the reviews for this book and i think that they are very unfair! I am not normally one to go for this sort of book but i found it hilarious, refreshing, light hearted and above all really good! So what if its predictable or a little sloppy in places. I am normally a thriller fan and therefore shunned this book when someone bought me it recently however for a change i thought id give it a go and i found i actually liked it. The story being that two sisters lives whom are completely the opposite of one anothers are suddenly swapped and each sister takes on another role. It is enlightening and is very much true in many places! For all those who have ever been dumped this will make you laugh! It is as though Adele Parks has followed every woman around after being dumped because I know that I saw myself in both Eliza And Martha! And Im sure others will agree! It is not a book of mystery nor a book of intrigue but it is a relaxing comfortable book that you dont have to think about just enjoy!I love this and give it a big thumbs up! A lovely comfy sh supra skytop l the reviews suggest that you should get one size larger and this is good advice. I ordered one size larger than I would normally buy and they are a perfect fit. Great shoes as you would expect from Shimano. ordered sunday they arrived on monday dinner time,well impressed with them would recommend for first time shoes Not being much of a cycling expert I had read a lot of favourable reviews of Shimano shoes, i'd also had very good service from Millets Sports in the past. I opted for these as they were sort of mid range, not too cheap (I've no idea if the Dynalast is worth it) and seem to have a fair range of features but equally not too crazy expensive for a first pair of road shoes.I'm a size 11 but having tried a few pairs of shoes on and read some reviews about having a bit of toe space I opted to go up half a size so ordered the 47.I've not been out on the bike yet but to wear around and a.
english dictionary meaning in hindi Disappointed that these were small both length and width-wise.
I have had this style of Merrell shoes before and saw no reason to change to any other make or design. Eight years with last pair.......comfortable and waterproof. But, I had not bought footwear on-line before ( hassle of returns etc) but decided to take a chance. All good. Delivery, product, service. Shoes are as I had hoped for - good fit etc. Very pleased indeed. ....and now for some serious Derbyshire striding.......
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Ok until first time in water, insole came adrift and had vivienne westwood jewellery eight but well built for shorter walks.They look more like trainers than walking shoes which I love as they are more trendy - proving walking gear doesn't have to be clumpy to be comfortable and supportive. I really love the colour - exactly as described.
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These were really well made and would have been good but I really need a size ee.Unfortunately I had to return them but not received conformation from sellers that they have received them backOr refunded the cost of them.Really nice colour and was a good design,disappointed that they did not fit.Maybe they ought to make them in wider width fittings has I am sure many people would buy them.
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Lind homers twice as Toronto defeats BaltimoreJun 5, 2011 - 8:50 PM
Yunel Escobar hit a three-run homer for the Blue Jays, who had lost three of four coming into Sunday's game.
Jo-Jo Reyes (2-4) gave up three runs on five hits over 6 1/3 innings to pick up his second straight win since going 28 games without a victory. Coming off his first career complete game against the Indians on May 30, Reyes walked four and struck out three.
Mark Reynolds hit a solo homer for the Orioles, who have lost seven of nine.
Jeremy Guthrie (2-8) allowed six runs on nine hits over five full frames to suffer the loss. He also walked three and struck out three.
Aaron Hill's RBI single in the first inning gave the Blue Jays an early edge.
The Orioles responded promptly with two runs in the home first. With men on first and second and one out, Vladimir Guerrero hit an RBI double to left. Derrek Lee grounded out to plate another run for a 2-1 lead.
Toronto tied the game on Lind's run-scoring base hit in the third. The Blue Jays added three more runs during their next at-bat to take control. Edwin Encarnacion singled and Jose Molina walked to put men on first and second with two outs. Escobar stepped to the plate and smacked Guthrie's offering over the wall in left for a 5-2 margin.
Lind added a solo shot to right in the fifth, but Baltimore got the run back in the home half on a Nick Markakis sacrifice fly.
The Blue Jays took a 7-3 lead on Lind's solo homer to right in the seventh.
Reynolds' solo homer off Jon Rauch in the ninth accounted for the final margin.
Game Notes
The Blue Jays squared off with Baltimore 18 times a year ago, winning 15 of those matchups, and took six of nine meetings on the road...Guthrie fell to 2-7 lifetime against the Blue Jays...The O's went 1-for-6 with runners in scoring position and stranded six.
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rootsMattDOOM777 Added 5 roots
Blue Jays 7, Orioles 4 FinalJun 13 1:04 PM
Jun 5 4:14 PM
- Mark Reynolds one-out, solo Home Run (9) to center. Nolan Reimold due up.
Blue Jays 7, Orioles 4 Bot 9, 1 OutJun 5 4:05 PM
- Adam Lind two-out, solo Home Run 2 (9) to right. Aaron Hill due up.
Blue Jays 7, Orioles 3 Top 7, 2 OutsJun 5 3:26 PM
- Adam Jones fouled out to first to end the inning.
Blue Jays 6, Orioles 3 End 5Jun 5 3:01 PM
- Adam Lind one-out, solo Home Run (8) to right. Aaron Hill due up.
Blue Jays 6, Orioles 2 Top 5, 1 OutJun 5 2:48 PM
- Yunel Escobar two-out, three-run Home Run (7) to left scored Edwin Encarnacion and Jose Molina. Corey Patterson due up.
Blue Jays 5, Orioles 2 Top 4, 2 OutsJun 5 2:36 PM
- Aaron Hill grounded into a double play, third to second to first On the play, Adam Lind out at second to end the inning.
Blue Jays 2, Orioles 2 Mid 3Jun 5 2:21 PM
- Derrek Lee grounded out third to first scored Adam Jones. On the play, Vladimir Guerrero advances to third. Runner on third with two outs and J.J. Hardy due up.
Blue Jays 1, Orioles 2 Bot 1, 2 OutsJun 5 1:57 PM
- Vladimir Guerrero ground-rule doubled to left scored Robert Andino. On the play, Adam Jones advances to third. Runners on second and third with one out and Derrek Lee due up.
Blue Jays 1, Orioles 1 Bot 1, 1 OutJun 5 1:56 PM
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rootsGeorge Added 5 roots
Blue Jays 1, Orioles 0 Bot 1, 0 OutsJun 5 1:52 PM
- Aaron Hill singled to right scored Jose Bautista. Aaron Hill thrown out at second to end the inning.
Blue Jays 1, Orioles 0 Mid 1Jun 5 1:48 PM
Top 1, 0 Outs
Jun 5 1:37 PM
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rootsGREGnKY Added 5 roots
Blue Jays vs. OriolesJun 5 8:02 AM
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rootsRUWTbot Added 13 roots
Blue Jays vs. OriolesMar 31 2:29 PM
Related News
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- Blue Jays-Yankees Preview May 23
- Ejections aplenty for Blue Jays lately May 23
- Baseball Capsules May 22
- Perez's 5 RBIs help Weaver and Angels top Orioles 10-2 May 22
- Hughes drops to 1-7 as Twins lose to Blue Jays 3-1 May 22
- Bautista, Donaldson homers propel Blue Jays over Twins 3-1 May 22
- Blue Jays manager Gibbons ejected for 4th time this season May 22
- Shoemaker strikes out 12, Angels lose 3-1 to Orioles May 22
- Wieters homers in ninth to lift Orioles past Angels, 3-1 May 22
- Orioles-Angels Preview May 22
- Baseball Capsules May 22


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