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Benefits of Banking
Cord Blood
About Cord Blood
Why Save Cord Blood
What Can Cord Blood Do
Diseases Treated with Stem Cells and its Potential Applications
How Cord Blood is Collected by your OBGYN
How Cord Blood is Processed and Stored
The Future of Stem Cells
Cord Lining
About Umbilical Cord
Why Bank Umbilical Cord Lining
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How is Umbilical Cord Lining Collected, Processed and Stored
Why Save Cord Blood
Top 10 reasons why you should consider banking cord blood…
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Cordlife Care360° Safeguard Program – We go that Extra Mile At Cordlife, we understand your needs and concerns as a parent. The Cordlife Care360° Safeguard…
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Because every child is unique. With new research on cellular…
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Best 9 Months
Pregnancy Myths
Tips for Yoga during pregnancy
Books to read when you are expecting
Ways to reduce stress when you are expecting
Right Diet during Pregnancy for an intelligent baby
Things to know about having sex during pregnancy
How to handle work during pregnancy
Bond with your Baby before he arrives
Techniques to lose post pregnancy weight
Expert Articles
Is Being An Older Couple A Problem?
IVF Journey in The East
Social Induction
Do Pregnant Women Need Fish Oil Supplementation?
Gynecology And The Beauty of Life
Non-Invasive Prenatal Testing (NIPT)
Public or Family Cord Blood Banking - Which One to Choose
Antenatal Screening Tests for Chromosomal Abnormalities
Preparing For Your Pregnancy
News & Events
Blessed Birth Raffle Online Promo
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FAQ on Cord Blood Banking for Expectant Parents
With over 30,000 cord blood transplants to date worldwide, cord…
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Cordlife e-News
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Press Releases
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Cordlife in the media
Umbilical Cords Rich in Stem Cells, Provide Unrivaled Health Benefits: Scientist
Cordlife Group appoints marketing agent in Myanmar
Lianhe Zaobao - 人生集团(Cordlife Group)上周五闭市后宣布签约委任Bio Secure公司为缅甸行销代理
04 November 2015
Cordlife Honoured As One Of Forbes Asia's "Best Under a Billion" Companies
3 August 2015
(Busines India), Ahead of its time
5 July 2015
(Channel News Asia), Distribution of SG50 Funpacks begins
5 July 2015
(Straits Times), Jalan Kayu residents get extra items in SG Funpacks
5 July 2015
(Next Insight), CORDLIFE: Pledges to donate $150K to needy pre-school kids in Jln Kayu
25 June 2015
(Business Times), Six Singapore companies make it to Forbes Asia's 'Best Under a Billion' list
25 June 2015
(AsiaOne), 6 S'pore firms on Forbes Asia's "Best Under A Billion" list
24 June 2015
(Forbes), Cordlife Harvests Stem Cells Of Newborns In Case Of A Rare Disease
14 July 2014
Shin Min Daily
3 March 2014
(The Business Times) Cordlife partners Cordlabs, CBBC to expand umbilical cord tissue storage services
3 March 2014
(The Straits Times) Cordlife Group in strategic alliance to provide umbilical cord tissue storage in China
June 2015
(Motherhood Magazine), Laboratory Director at Cordlife Group Limited answers your cord blood banking related questions.
29 May 2015
Mother & Baby
29 May 2015
(The New Age Parents), "New Cord Blood Research: Treating Autism In Children"
29 May 2015
(Health Radar), "Treating Autism with Cord Blood"
25 April 2015
(Shape), "Understanding Autism in Children"
25 March 2015
(theAsianparent), "Cordlife to front stem cell trial for childhood autism in Singapore"
October 16, 2014
(Commuter Express) Your baby's precious CORD blood can save his precious life
October 11, 2014
(Manila Bulletin) A New Life
September 22, 2014
(PR News), Your Baby's Precious Cord Blood Can Save His Precious Life
October 7, 2014
(PR News), Cord Blood, New Hope for Leukemia
10 October 2014
(Business Mirror) Cord Blood a new hope for Leukemia
6 October 2014
(Malaya) Cord blood , a new hope for Leukemia
26 September 2014
(The Philippine Star) Your baby's precious Cord blood can save his precious life
22 September 2014
(Malaya Business Insight) Your baby's precious Cord blood can save his precious life
March 13, 2014
(The Philippine Star) New parents Jolina and Mark Escueta's precious gift to son Pele
February 10, 2014
(The Philippine Star) Cord blood stem cells - a new hope for cerebral palsy, neuroblastoma patients.
January 06, 2014
(The Philippine Star) From bad blood to good: Cord blood stem cells at work
November 11, 2013
(Medical Tribune) Cord blood infusion may have some benefits in cerebral palsy
October 29, 2013
(The Philippine Star) The Stem Cells that Save Lives
November 12, 2013
(Malaya Business Insight) The stem cells that save lives
November 4, 2013
(Manila Standard Today) New technology aims to save lives through stem cells
November 4, 2013
(Malaya) Umbilical Cord Banking
October 23, 2013
(Mami and Family) Cordlife Philippines Launches Umbilical Cord Banking
October 17, 2013
Cordlife Philippines Launches Umbilical Cord Banking
October 19, 2013
One Chance, One Choice on Umbilical and Cord Blood Banking
September 19 2013
(Interaksyon) Is Cord Blood Banking Right for your Family
September 3, 2013
(Smart Parenting) Cordlife Philippines launches affordable umbilical cord banking services
September 3 2013
(Philippine Star) Cord banking : Health insurance for your child
August 12, 2013
(Commuter Express) Cordlife Philippines Launches Umbilical Cord Banking
August 12, 2013
(The Straits Times) Singapore's Cordlife Group launches umbilical cord tissue banking in Philippines
August 13, 2013
(The Daily Tribune) Cordlife Phils. launches umbilical cord banking
September 26, 2012
(South China Morning Post) Cold Comfort
Jan 26th, 2012
(Business Mirror) The gift of a lifetime
Jan 24th, 2012
(The Philippine Star) A Priceless Gift
Dec 6th, 2011
(The Philippine STAR) The gift of a lifetime
August 11th, 2011
Neurosurgeon Makes History
July 12th, 2011
Of new leaderships and medical breakthroughs involving stored cord blood
August 18th, 2011
Have you ever heard of cord blood stem cell banking
August 2, 2011
(The Philippine STAR) Treating cerebral palsy with cord blood stem cells
July 20, 2011
(Jakarta Post) Investing in future health through stem cell technology
July 22, 2011
(The Daily Tribune) Philippines' first stem cell bank
July 12, 2011
(Manila Buttetin) Of new Leaderships and medical breakthroughs involving stored cord blood
July 2, 2011
(Philippine Daily Inquirer) The 'safety net' for newborns, adults
July 1, 2011
(Business World) Putting an end to cerebral palsy and other life-threatening diseases
June 07, 2011
(The Philippine Star)The most important thing your ob-gyne should tell you
Feb 18, 2011
CordLife Champions Kids Party Raymond Wong: Parents' Must-Do – Cord Blood Banking at Globetrotters 6 Dec 2008
Jul 29, 2010
(pharmabiz.com)Cord Life India to launch cord blood banking services in Mumbai soon
Jul 29, 2010
(Business Line)CordLife may start development unit in India
Jul 08, 2010
(The Telegraph)Stem cell trial with watchdog nod
Jul 06, 2010
(ADgully)Hanmer MS&L gets Cordlife's account
Apr 04, 2010
(Business Mirror)CordLife opens Manila facility
Apr 04, 2010
(tribuneonline.org)Once you choose Hope, anything is possible
Apr 04, 2010
(Female Network)Storing your baby's cord blood can save your kids' lives
Apr 04, 2010
(Inquirer Global Nation)An investment that may save your child's life (with VIDEO)
Apr 04, 2010
(Inquirer.net)An investment that may save your child's life
Apr 04, 2010
(The Carillon)First Stem-Cell Bank Opens in RP
Feb 24, 2010
(Business Mirror)First stemcell bank opens in RP
Feb 24, 2010
(Manila Standard Today)Cordlife launches first cord blood bank in RP
Dec 02, 2010
(The Straits Times)Saved by stem cells
Nov 3, 2010
TVB Weekly The Most Popular Brand Award 2010— The Most Popular Cord Blood Bank (Chinese)
Nov 3, 2010
(SingTao Daily)CordLife CEO urges for the legistration of cord blood banking regulations
Oct 29, 2010
APEA 2010— Most Outstanding Entrepreneurship Award (Chinese)
Jan 29, 2010
Nov 18, 2010
(BioSpectrum)Cordlife to invest $1mn in strategic talent management
Nov 16, 2010
(Marketing-Interactive.com)CordLife Pours $1m To Groom Fresh Blood
Nov 16, 2010
(Human Resources)CordLife Pours $1m To Groom Fresh Blood
Oct 18, 2010
(Business World) The Cord That Sells
Oct 18, 2010
(TIMES OF INDIA) Stem cell industry
Oct 15, 2010
(Vinidio) Cordlife Introduces New Services for Stem Cell Banking
Oct 6, 2010
(Pioneer - Avenues) Stem of life
Oct 1, 2010
(DNA - DNA Money) Stem-cell bankers seek to tap India
Oct 1, 2010
(Express Healthcare) CordLife Introduces New Services for Stem Cell Banking
Sep 16, 2010
(Prahaar) Cordlife
Sep 15, 2010
(Financial Express) CordLife Sciences starts Mumbai collection centre
Sep 14, 2010
(IBN Live)Stem cell bank CordLife opens Western region operations
Sep 14, 2010
(indiainfoline) Cordlife Sciences open stem cell collection centre in Mumbai
Sep 14, 2010
(newkerala.com) Cordlife Sciences open stem cell collection centre in Mumbai
Sep 14, 2010
(webindia123.com) Cordlife Sciences open stem cell collection centre in Mumbai
Aug 29, 2010
(Chinese, Lianhe Zaobao)CordLife CEO Steven Fang media interview
Aug 17, 2010
(prabaht khabar) Cordlife
Aug 13, 2010
(Hindustan Times - HT Live) Take stemm cells abroad at zero cost
Aug 09, 2010
(newkerala.com)CordLife offers 'guarantee' on cord blood
Aug 06, 2010
(SAKHSHI) Stem cell industry
Aug 05, 2010
(genewired.com)CordLife India Official Launch – Mr. Steven Fang addressed the media in a Press Room in Kolkata, India.
Aug 04, 2010
(Hindu Business Line)Cordlife guarantee scheme
Aug 03, 2010
(India Blooms)CordLife offers 'guarantee' on cord blood
Aug 03, 2010
(Pillscribe)CordLife offers replacement warranty for cord blood banking clients
Aug 03, 2010
(India Infoline)CordLife introduces Quality Guarantee programme
Aug 03, 2010
(BioSpectrum)CordLife introduces 'Quality Guarantee' program for cord blood in India
Jul 30, 2010
(newsonprojects.com)CordLife plans to set up development unit in India
Jul 29, 2010
(Pillscribe)Cord Life expands cord blood banking to Mumbai
Nov 6th, 2009
Stem cells bring cure and hope
Nov 6th, 2009
Amar Ujala (AU)
Nov 5th, 2009
New stem cell technology by CordLife
Nov 4th, 2009
Nov 4th, 2009
Prabhat Khabar
Nov 4th, 2009
Sangbad Pratidin
Nov 4th, 2009
Stem cells cures for diabetes
Nov 4th, 2009
Cell therapy for ulcers
Nov 4th, 2009
Stem cell banking launched
January 14th, 2009
CordLife to set up chain in India (article highlights)
Dec 3, 2009 (909kb)
Straits Time - Cerebral Palsy Baby helped by cord blood
Dec 3th, 2009 (278kb)
香港太陽報 -植臍帶血救腦病童
Dec 3th, 2009 (316kb)
香港東方日報 -首宗自體臍帶血移植治療腦痳痺 女童露曙光
October 28, 2009 (423kb)
香港經濟日報 - 臍帶血庫需求增海嘯收後入升6成
Sep 2nd, 2009 (802kb)
The Business Times - CordLife in the black with A$4.2M profit
June, 2009 (618kb)
surveyed, CordLife was ranked 15th among Asia's 50 fast-est growing companies in the Asia Pacific region (article highlights)
March, 2009 (1140kb)
Blood Insurance (article highlights)
March 20, 2009 (1003kb)
The Business Times - CordLife Set to post profit, recruit staff
February 21st, 2009 (910kb)
Lian He Zao Bao - These are just some of the reasons why we believe in private cord blood banking
February 21st, 2009 (910kb)
Straits Times - These are just some of the reasons why we believe in private cord blood banking
February 10th, 2009 (618kb)
A newer, better way to harvest stem cells
November 27th, 2008 (904kb)
CordLife Year of the Entrepreneur (article highlights)
June 18th, 2008 (774kb)
CordLife Champion - Kung Fu Panda movie screening on 18 June 2008
October 30th, 2007
CordLife Opens Cord Blood Facility in Jakarta
October 25th, 2007
Homegrown cord blood bank, Cordlife, is venturing into India for the first time by the end of the year, when its facility in Kolkatta starts operations.
October 25th, 2007
Tapping into India's healthcare sector
October 25th, 2007
India's huge population a big draw to CordLife (article highlights)
October 25th, 2007
India's huge population a big draw to CordLife
October 22nd, 2007
Third option for stem cell storage
October 12nd, 2007
Darah Tali Pusat dan Sebuah Asa
October 6th, 2007
More Cord Blood with New Facility
October 5th, 2007
Minister of Health Opens Umbilical Cord Blood Bank Cordlife Indonesia
October 4th, 2007 (184kb)
CordLife to open new, bigger facility in Singapore
July 18th, 2007 (246kb)
New lease on life
July 2007 (2592kb)
Where Blood is its Business
July 2007 (1205kb)
CordLife Completes Technology Restructuring
July 2007 (1286kb)
BioMed Singapore
6th June 2007 (199kb)
Cord Blood and its uses
18th May 2007 (23kb)
Cordlife To Rationalise Technology And Product Development Activities, To Further Focus On Cord Blood Banking Business
May 22nd, 2007 (134kb)
3 cord blood banks in S'pore
May 9th, 2007(42kb)
How a baby helped save his big brother's life
Mar 9th, 2007(184kb)
New fund aim to draw young scientiscs
Mar 9th, 2007(1120kb)
CyGenics to focus on cord blood banking (article highlights)
April 3rd, 2007(192kb)
CyGenics to focus on cord blood banking
April, 2007(1094kb)
Motherhood - Question and Answer
January 10th, 2007(1566kb)
Asia is Stem Cell Central
January - February, 2007(1185kb)
Stem Cell: Body, Heal Thyself
December 1st, 2006 (29kb)
Kalbe Farma keen in developing stem cell research with CordLife
December 1st, 2006 (29kb)
CyGenics Asian Healthcare Presence Expanded in Indonesia
November 21th, 2006 (55kb)
In brief: PSIRON, CyGenics & A New Web Tool
November 1st, 2006 (55kb)
Indonesia akan memiliki "Bank Tali Pusat"
October 18th, 2006 (212kb)
Kalbe Farma Concern Terhadap Dunia Kesehatan
October 17th, 2006 (212kb)
Terapi Sel Induk dari Darah Tali Pusar
October 17th, 2006 (212kb)
Manfaat Tali Pusat bayi (1) Efektif untuk atasi kanker
October 17th, 2006 (212kb)
CordLife Indonesia Officially Launched
October 17th, 2006 (212kb)
Kalbe Farma buy into CyGenics subsidiary
October 17th, 2006 (212kb)
CyGenics official JV signing
October 16th, 2006 (212kb)
Bank Darah Tali Pusat Didirikan di Indonesia
October 16th, 2006 (212kb)
Indonesia to have umbilical cord blood bank next year
October 16th, 2006 (212kb)
Tali pusat sembuhkan penyakit gawat
October 16th, 2006 (212kb)
Kalbe Farma Dirikan Bank Penyimpanan Darah Tali Pusat
October 16th, 2006 (212kb)
Indonesia Lakukan Riset Terapi Sel
October 16th, 2006 (212kb)
Bank tali Pusat - Kini Tersedia in Indonesia
October 14th, 2006 (212kb)
Ri Kembangkan Riset Sel Induk Untuk Pemyebuhan Penyakit
October 14th, 2006 (212kb)
Ri Kembangkan Riset Sel Induk Untuk Pemyebuhan Penyakit
July 2006 (351kb)
The New Cure
May 16, 2006 (54kb)
Cord blood unit holds out hope
April 30th, 2006 (328kb)
Going Global Singapore Style
January 15th, 2006 (252kb)
CyGenics expand cord blood banking into India
December 12th, 2006 (212kb)
CyGenics Pioneering Technology
December 4th, 2006 (214kb)
Two local firm win prestiguous tech pioneer award
September 18th, 2006 (39kb)
Your baby's blood can save your life
April 23th, 2006 (545kb)
More foreigners are storing cord blood in Singapore
February 27th, 2006 (190kb)
Now there is cord blood insurance
February 22th, 2006 (181kb)
NTUC Income, CordLife team up
February 21th, 2006 (113kb)
Stem cell transplant patients can claim medical expenses under insurance
February 21th, 2006(50kb)
Patients needing stem cell transplant using cord blood can now claim their medical expenses under a new insurance policy
February 8th, 2006(349kb)
Our Little Saviour
January 2006 (203kb)
Banking on Excellence
September 7th, 2005 (238kb)
World Recognition for CordLife
September 3rd - 9th, 2005 (81kb)
Cordlife gets world recognition
July 2005 (58kb)
International Businesses Flock to Hong Kong
Asia Pacific BioTech News, May 2005(572kb)
CyGenics Files Investigational New Drug Application
HK Magazine, April 8th, 2005 (705kb)
Cell Block HK
Wen Wei Po, April 6th, 2005 (174kb)
Cord Blood Stem Cell can treat more then 70 type of diseases
The Sun, March 31st, 2005 (457kb)
Hong Kong private stem cell banking facilities
South China Morning Post, March 31st, 2005 (187kb)
Joint effort urged on stem cell
Sing Bao Daily, March 31st, 2005 (379kb)
Hong Kong Second Stem Cell banking facility
Hong Kong Economic Times, March 31st, 2005 (400kb)
Hong Kong First Stem Cell banking facility
China Daily, March 31st, 2005 (217kb)
CordLife set up stem cell bank in HK
China Daily, March 31st, 2005 (217kb)
CordLife set up stem cell bank in HK
Apple Daily, March 31st, 2005 (652kb)
Cord Blood can cure more then 70 type of diseases
South China Morning Post, March 24th, 2005 (163kb)
Events Diary
The Strait Times, March 22nd, 2005 (146kb)
Business Chiefs to mentor student entrepreneurs
Business Times, February 9th, 2005 (100kb)
Cordlife set to expand into HK market
From Rocket Fuel to T-Cells.(863kb)
BioProcessing Journal, Jan/Feb 2005
EDB Singapore, December 1st, 2004 (47kb)
Cordlife opens second tissue processing & storage facility
Nov/Dec 2004
Nov/Dec 2004
www.bio-med.com.sg, November 30th, 04 (47kb)
New Association To Boost Singapore's Bioscience Industry
www.bio-med.com.sg, September 28th, 2004 (48kb)
CordLife Opens Second Tissue Processing and Storage Facility in Singapore
Asia Pacific Biotech News, October 30th, 2004 (23kb)
CordLife Forms a New Company
www.smh.com.au, October 7th, 2004 (23kb)
CyGenics opens new cord blood bank
September 29th, 2004 (88kb
CyGenics open new Singapore Facility
September 29th, 2004 (119kb)
CordLife Expands Operations
September 27th, 2004 (117kb)
Leukaemia Boy saved-by baby sister's Cord Blood (
Channel News Asia: September 28th, 2004 (85kb)
Private Cord Blood Bank expands Singapore facilities
July 1st, 2004 (304kb)
Leukaemia Boy saved-by baby sister's Cord Blood (Chinese Newspapers, Lianhe Wanbao)
July 1st, 2004 (192kb)
Leukaemia Boy saved-by baby sister's Cord Blood
July 1st, 2004 (384kb)
Leukaemia Boy saved-by baby sister's Cord Blood (China Press,
Business Times, January 24th, 2004 (130kb)
CordLife set up unit to push global sales
Straits Times Interactive, January 20th, 2004 (170kb)
(170kb) First public cord blood bank set up here
Media Channel News Asia, January 19th 2004
Private operators welcome Singapore's new public cord blood bank
January 19th, 2004 (128kb)
Singapore to open S$15m public cord-blood bank
Interview with Capital 958 FM, September 10th, 2003 (62.2kb)
The Spirit of Enterprise
Channel 8 News, August 20th, 2003 (57kb)
More local parents are choosing to store their baby's cord blood
Lianhe Zaobao, November 6th, 2003 (99.7kb)
CordLife receives 2nd round funding
Singapore's Homegrown Entreprenuers (85kb)
CEO Receives Spirit of Enterprise Award
Reuters, November 14th, 2003(100kb)
As electronihttp://www.cordlife.com/news/pdf_cordlifeNews/cordlife_010304_2.pdfcs founders Singapore turns to drugs
Strait Time: October 10th, 2003 (254kb)
Biotech gamble payoff for Cordlife founder
Business Times: September 11th, 2003 (141kb)
Spirit of Enterprise
BioMed Singapore (www.biomed-singapore.com): August 8th, 2003 (111kb)
Cordlife's Success In Stem Cell Banking & Innovation
Asia Pacific Biotech News: August 4th, 2003 (799kb)
CordLife Launches Peripheral Blood Stem Cell Processing and Banking Services
Lianhe Zaobao: July 03, 2003 (261kb)
Stem Cell Technology lets your dream come true!
Far Eastern Economic Review: June 26th, 2003 (1.32mb)
Banking on a chance at life
June 25th, 2003(79.6kb)
The Lure of Biotech
The Straits Times: Tuesday, June 24th, 2003 (123kb)
Singapore team at biotech meeting
June 23th, 2003 (515kb)
CordLife acquires Cytomatrix Australian Bio Tech News
The Straits Times: Monday, June 23th, 2003 (318kb)
First-hand look inside a stem cell lab
May 23rd - 29th, 2003 (289kb)
Cytomatrix goes global with CordLife merger deal
Technopreneurs.net (www.technopreneurs.net.my): May 12th, 2003 (216kb)
Singapore/Europe/Australia: Plans of CordLife
Business Times: Monday, May 12th, 2003 (269kb)
Singapore Firm Aims for Stem Cell Market
BioExchange (www.bioexchange.com): Monday, May 5th, 2003 (58kb)
Singapore-based CordLife Acquires US-based Cytomatrix
Lianh Zaobao: Saturday, May 3th, 2003 (94kb)
CordLife Acquires US Biotech Company Cytomatrix
Australian BioTech News: May 2nd, 2003 (191kb)
Singapore cord blood firm to set up in Australia
The Publication of the British Chamber of Commerce, Singapore: Summer 2003 (1.73mb)
UK scientists champion Singapore's bioscience industry Orient
Elle Singapore: May 2002 (68kb)
Test Tube Mummies
Health Today: April 2002 (64kb)
Asian Business: Thursday, April 4th, 2002 (125kb)
Potions, Pills and Pioneers
Nikkei Weekly: Monday, March 4th, 2002 (64kb)
Umbilical cord bank takes lead in research on stem cells
The Straits Times: Wednesday, February 27th, 2002 (52kb)
In the works - cheap way to grow stem cells
Her World: February 2002 (42kb)
Wonder Man - An interview with CordLife founder Steven Fang
July 22nd, 2011
Philippines' first stem cell bank
Frost.com: Monday, October 15th, 2001 (44kb)
Banking on Cord Blood in Asia
News radio 93.8: Tuesday, September 25th, 2001 (60kb)
CordLife HealthChat
The Straits Times: Monday, September 24th, 2001 (64kb)
10 pay to store kids' cord blood against disease
The Straits Times: Saturday, September 1st, 2001 (79kb)
Banking on cord stem cells
The Straits Times (51kb)
Singapore company wants to build Asian umbilical cord banks for stem cell research
Enrol Now
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Impress your guests by serving unique and flavorful drinks in a shooter glass. To keep these drinks fresh and protected from airborne contaminants, use the Emi Yoshi EMI-607LP Clear Plastic Shooter Glass Lid 2 oz.
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subset: commoncrawl


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The changing of seasons means new fashion! With that in mind, Capitol Couture came out with a new summer issue called Zoetic Sol and it features Johanna Mason! Check out her Capitol Profile picture:
The District 7 victor looks pretty fashionable with a dress constructed to look like paper and bark! Read her cover story here and let us know what you think of the new Capitol Couture issue!
Source: Capitol Couture


text:
Today we released an update to Parallels Desktop 7 for Mac that includes support for Windows 8 Developer Preview. The new build, 7.0.14924, is available now by going to the Parallels Desktop menu and selecting "Check for Updates." Now you can run Windows 8 through its paces on your Mac just to see what it looks like, or to start developing apps for the new OS.
Step 1: In order to install the preview, first download the OS from the Windows 8 developer's site here. The download process will likely take 45 minutes to an hour.
Step 2: Open Parallels Desktop 7, select the File dropdown menu and then "New." In the Parallels Wizard, select "Install Windows from DVD or Image File." Select the Windows 8 Developer Preview .iso file you just downloaded.
Step 3: Follow the setup process in Windows 8 until you see the Installing Windows dialogue box. The installation will likely take 10 minutes.
Step 4: Begin using Windows 8!
Now that you have set up Windows 8 in Parallels, you will be able to quickly and easily access it from your Virtual Machines list in Parallels Desktop 7. Play around with it, see what you do and don't like, and take it through its paces. If something goes wrong, no need to worry because you can just delete the instance and re-install without affecting the rest of your Mac.
Now with support for Windows 8 Developer Preview, Parallels Desktop 7 is a veritable developer's playground. Software, mobile and Web developers can safely and simultaneously test a variety of operating systems as guests, as well as develop and test applications on them without risking their development machines. You can run side-by-side the following OSes:
- Windows 8 Developer Preview and other versions of Windows
- Windows 7
- OS X Lion as a guest on Macs running OS X Lion
- Google Chrome OS
- Fedora
- Ubuntu
The 7.0.14924 update also improves the general performance of Parallels Desktop 7 for Mac, including optimized CPU usage when Parallels Desktop 7 is idle, improved compatibility with Quicken 2011 personal finance software, and improved support for Autodesk 3DS Max 2012 3D modeling software.
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1 Reply
Oct 6, 2011 at 11:43 UTC
This is great news!
This discussion has been inactive for over a year.
You may get a better answer to your question by starting a new discussion.


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Description: Foreign Intervention in Africa chronicles the foreign political and military interventions in Africa during the periods of decolonization (1956-1975) and the Cold War (1945-1991), as well as during the periods of state collapse (1991-2001) and the "global war on terror" (2001-2010). In the first two periods, the most significant intervention was extra-continental. The United States, the Soviet Union, China, Cuba, and the former colonial powers entangled themselves in countless African conflicts. During the period of state collapse, the most consequential interventions were intra-continental. African governments, sometimes assisted by powers outside the continent, supported warlords, dictators, and dissident movements in neighboring countries and fought for control of their neighbors' resources. The global war on terror, like the Cold War, increased the foreign military presence on the African continent and generated external support for repressive governments. In each of these cases, external interests altered the dynamics of Africa's internal struggles, escalating local conflicts into larger conflagrations, with devastating effects on African peoples.
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Copyright year: 2013Publisher: Cambridge University PressPublication date: 3/25/2013Binding: PaperbackPages: 288Size: 6.00" wide x 9.00" long x 0.50" tall Weight: 1.166
Elizabeth Schmidt is a contributing editor to the literary magazine Open City and poetry reviewer for the New York Times Book Review.
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BLUES are poised to sign up Olivier Bernard after he accepted an invite to join them for their pre-season tour to Norway.
Manager Steve Bruce wants a good look at the French left-back after he rejected their last-ditch overtures during January's transfer window.
Bernard was expected to fly here later today as Blues' preparations continued with a double training session.
Although Bernard is available on a Bosman free transfer after the end of his short-term contract at Southampton, Bruce won't rush into anything.
But the very fact that he has rekindled his interest, and that Bernard has agreed to what effectively amounts to a trial, suggests a deal is in the offing.
Blues were poised to buy Bernard from Newcastle United only for the Magpies to scrap the deal because of an injury to Celestine Babayaro.
But, to Blues' surprise and annoyance, Newcastle then did a u-turn and Southampton snaffled Bernard up for nothing upon the cancellation of his contract.
Blues tried to persuade him to come to St Andrew's on the last day of trading in January, and they offered him a bigger salary.
But Bernard said he had already committed to Southampton and Blues were left frustrated.
Following Southampton's relegation, manager Harry Redknapp said Bernard would not be staying at St Mary's and that he had lined up another move - to Blues.
But Bruce denied this and said that he wouldn't sign a player who had snubbed him in such fashion. However, circumstances have changed and Bruce is eager to bolster his options on the left-hand side of the team.
Jamie Clapham was left behind in Birmingham due to a virus and has battled against injury and illness for the past 18 months.
Stan Lazaridis had an injury-plagued last campaign and David Dunn might not be available until September or October due to complex back surgery.
Meanwhile, Blues got a shock during last night's opening tour match at Egersund, despite a 2-0 victory.
The promoter of the friendly, 38-year-old postman Kjell Avendal, was sent on by the hosts for the final minute as a substitute - and he was wearing spectacles.
His introduction produced rapturous applause from a crowd of around 1,200 as Avendal is a well known local character.
But Blues didn't know quite what to do when confronted by the wannabe striker, who looked out of place but fortunately didn't get anywhere near the ball during his brief participation.
He said: "It was a massive surprise for me from the club, and that's why I had to wear my glasses because my contact lenses were at home.
"It was a great gesture and it was memorable for me to play against a Premier League team like Birmingham."


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July 4th, 2016
Episode 133 of 188 episodes
On this special edition of "60 Minutes," it is a night at the movies. 'Star Wars: The Force Awakens" was highly anticipated since it was first announced. Director J.J Abrams -- the new force behind one of the most successful franchises in movie history talks about filling the shoes of George Lucas, and introducing Star Wars to a new generation of fans. Lesley Stahl looks back at the career of veteran actor Michael Caine. Steve Kroft reports on the difficult task of bringing the life of Apple Co-Founder Steve Jobs to the big screen.
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Welcome to the Brain Training Podcast, the daily audio workout for your head. In this podcast we have two games for you, each with three rounds which get progressively harder. To enjoy the full experience, relax, and avoid distractions whilst you listen.


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Today's Party Feature is from Nina of Designs by Nina in Spain. This is the party she hosted for her daughter's first birthday and was done in a beautiful pink and aqua color scheme, Nina created all of the beautiful stationary and made most of the yummy looking desserts herself! Be sure to check out all of the gorgeous details from the cookie wands to the inside of the beautiful cake!
Thank you so much for sharing your daughter's party with us Nina, you did an incredible job!


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Who would have thought back in 1998 at the inaugural Petit Le Mans race, that Don Panoz's idea would take off and retain its initial outlook on endurance racing to the point of being one of the top sportscar racing series in the world. Well,...
Who would have thought back in 1998 at the inaugural Petit Le Mans race, that Don Panoz's idea would take off and retain its initial outlook on endurance racing to the point of being one of the top sportscar racing series in the world. Well, folks, that is what the American Le Mans Series is: a vital arena where top teams can show their products, designs and development programs on race tracks throughout North America.
The top of the line Prototypes, LMP 1 and LMP 2 are specially built by manufacturers such as Lola, Audis, Riley & Scott, Panoz. Bentley and Cadillac have also competed in the past and won.
The class names have changed for this year with minor modifications from the previous 900 and 675 Le Mans Prototypes, but the game is the same: Will Dyson Racing be able to topple the Audi teams as they did last year on occasion, based on the LMP1s' weight advantage over the more powerful LMP2 cars?
It was not just the inconsistency of the rules that motivated Panoz to start the series, it also was "the fact that nobody paid any attention to the fans!"
The term "For the Fans" was developed and survived, not just as a coined term to draw fans but, in all honesty, the fans are a highlight of the series. They can be seen walking though the paddock talking to teams, drivers, series officials, and being allowed to really take a good long look at the racing machines.
The fans vote for the "From the Fans" award given to the person/group they feel made a difference during the season - last year's winner was Rob Dyson, owner and former top-notch endurance driver of Dyson Racing. They also vote for "Most Popular Driver", an award that Jan Magnussen has garnered two years in a row. This series is "For the Fans".
Nine events are scheduled for the 2004 season starting with the historic Sebring 12 Hours on March 20 with an entry list that is Who's Who in racing. Lime Rock will host their first ALMS event and the season ender will be at Laguna Seca. Due to the Le Mans 24 Hours testing, qualifying and race, the ALMS takes time off to allow the invited teams to prepare and run Le Mans. Thus, the calendar is blank after Sebring until the June 25th when they return to Mid-Ohio for the race on June 27.
Sebring preview:
The legendary drivers who have won the event include Stirling Moss, Mario Andretti, Dan Gurney, Bob and Al Holbert and Phil Hill. More recent winners are: Frank Biela, Tom Kristensen, Emanuele Prirro (Audi), Rinaldo Capello, Michele Alboreto, Laurent Aiello (Audi) , Johnny Herbert, Rinaldo Capello, Christian Pescatori (Audi), and Frank Biela, Marco Werner, Philipp Peter (Audi).
Which now leads to the question, will Audi win its fifth consecutive Sebring victory? Odds are no doubt in their favor but one cannot count out the Dyson Racing team who challenged Audi for bragging rights last year.
Biela, however, will not be returning to the series to defend his championship. "I will be racing in the DTM (German Touring Car Masters) for Audi again this year and so only have the opportunity to race the Audi R8 at Sebring and Le Mans. Both of these races are 'classic' sportscar races and I would love to win them again - especially for my new Audi Sport UK Team Veloqx outfit. Sebring was the venue of my first sportscar victory - four years ago."
Co-champion and former teammate Werner will return, this time with Champion Racing. "I am very happy to be back and driving for Champion Racing this time. It was a good first race for me last year so I am hoping it will be the same. For Sebring especially, I would like very much to be on that podium in first place again, that is my goal."
Sebring is not an easy road course, built around and on an old World War II training airport in central Florida. The track itself still run on the old concrete used by the airfield, leaning itself to why it is a very unique event. There is no huge light fixtures so portions of the track are still in the dark, allowing one to see the streaks of just the racers headlights which is amazing to watch. The drivers however have to manipulate their fast sleek vehicles through the dark areas. Sebring is one tough endurance race. Surviving is a major goal.
"You don't even think of doing anything risky early in the race," commented Darren Law, co-pilot of the Flying Lizard Motorsports Porsche. "But if you have an hour left and a win or podium finish is in sight, then maybe it is worth taking risks. That's when you pat yourself on the back for doing your part to make sure the car has something left."
Alex Job Racing has been the top team and GT class winner three years straight. Driver Lucas Luhr might have extra pressure for this event as he is currently tied with four consecutive class wins at Sebring with Bob Holbert. A win this weekend would give Luhr the sole holder in the record books, "Bob Holbert is a legendary Porsche driver, being recognized in the same history book as him will be a special memory in my career," expressed Luhr who already feels that in itself is an honor.
Editor's Note: Motorsport.com's Richard Sloop interviewed Don Panoz, the quotes from Panoz are from that interview.


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login with
Feel better lil one!
I think this is one of the first photos she's missing her infectious smile. I hope she feels better soon!
Awww poor bibb! Stay warm!
Thanks guys i think shes feeling a lot better today.
About Leah Carlson
Born: Troy, Ohio
Current: Troy, Ohio
Birth: December 10
On Moms.com since: Nov 8, 2013
I am Leah, a 26 year old first time mom. My daughter Holly was born March 9,2013. I am primarily a stay at home mom but also work part time as a Figure Skating Coach. My husband and I are enjoying life as new parents. SITE HOSTESS


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The Committee on Transportation and Infrastructure today approved a number of General Services Administration (GSA) leases for federal work space that will save taxpayers over $350 million with reductions in space for federal agencies and more efficient utilization rates.
Rep. Lou Barletta (R-PA), the Chairman of the Subcommittee on Economic Development, Public Buildings, and Emergency Management -- which has jurisdiction of GSA's management of federal property -- highlighted the benefits to taxpayers.
"The lease resolutions before us today will save the taxpayer more than $350 million over the terms of the leases," Barletta said. "These savings are realized by reducing the space footprint of agencies, putting more people into less space, or lowering rental rates. And, because of the work of this Committee, agencies are finally getting the message that we cannot operate as if it is business as usual."
The Committee also approved its Views and Estimates of the Fiscal Year 2014 budget, which are required under current law and House rules to be submitted to the Committee on the Budget.
"The Views and Estimates reflect the Committee's belief that investment in transportation infrastructure is necessary to ensure the safe and efficient movement of people and goods, increase economic growth, and maintain our global economic competitiveness," said Committee on Transportation and Infrastructure Chairman Bill Shuster. The Views and Estimates can be read here.
The Committee also approved H. Con. Res. 18, Authorizing the use of the Capitol Grounds for the National Peace Officers' Memorial Service; and H. Con. Res. 19, Authorizing the use of the Capitol Grounds for the Greater Washington Soap Box Derby.
Source: http://transportation.house.gov/press-release/committee-approves-gsa-measures-will-save-taxpayers-350-million


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Applications for Summer 2018 are now open.
If there is one commonality among all members of the human race it is this: everyone eats. However, what each of us eats depends to a great degree on where (geography) and when (history) we live. While food is a visceral necessity, it is also one of the central means by which people throughout time and across cultures have created and expressed their identities as members of different ethnic, racial, and religious groups, classes and nations. By examining food historically, we can see how these issues have developed over time and across cultures in relation to political, social and economic changes.
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Course Description
In La Cucina Della Nonna (grandmother's kitchen) class we will study the origins and assimilation of Italian cuisine in American history and culture. Readings will focus on the migratory experience of Italian Americans in the late 19th century and 20th century and the impact of that immigration on American society and culture, especially American cuisine. We will explore the relationship between food, culture and gender with special attention to the ways in which Italian American women have been the conduits of Italian culture and cuisine in their roles as mothers and grandmothers. In our readings we will also explore the prominent role of food, masculinity and Italian Americans in popular culture such as The Godfather. The travel portion of this course will allow you to experience the "push" factor of the migratory process in the "push/pull" historical theory of migration by focusing on the southern Italian and Sicilian regions responsible for the majority of Italian migration to the United States in this era. It will also enable you to understand the ways in which food is transformed, as well as migrants, in the process of acculturation, and for this historical period, the process of "Americanization." Students are required to attend pre-departure classes in the week prior to European travel. Course assignments include considerable pre-departure readings, a daily journal while traveling, and an analytic essay due one week after our return.
» View sample of Excursions & Itinerary (Subject to Change)
Program Information
Course: WGS 165/HIS 165 Gendered History of Food: La Cucina Della Nonna
Liberal Learning: Social Change in Historical Perspective; Gender; Global
Dates: May 21-June 11, 2017
Program Director: Dr. Ann Marie Nicolosi, Associate Professor and Chair, Women's and Gender Studies and History
Eligibility: No Pre-Requisites, Language Requirements, or GPA Restrictions – Open to all students (including current first-year students)
Summer 2017 Program Fee: $5,392.88
Learning Outcomes for the Course
Students will:
- Analyze historical and contemporary systems of privilege and oppression, with special attention to the ways gender intersects with class, ethnicity, sexuality, religion, and nationality. By examining how these forces contributed to food access and preparation, students will gain an understanding of the "push" factor in Italian American migration and the emphasis Italian Americans placed on food culture.
- Gain an understanding of gender as a central category of analysis that compels constant inquiry into the production and legitimation of knowledge
- Gain an Understanding of the significance of women's historical and contemporary contributions to Italian and Italian American culture and society
- Gain a historical understanding of links between past and present, specifically of the migration process of Italians in the late 19th and early 20th century and the resultant acculturation process.
- Learn to discern the story in history and the relationship between historical narrative and myth in immigration
- Learn the role of food preparation and consumption in preserving and transmitting culture, particularly the gender roles that shape this process.
- Analyze secondary works strategically (for main argument) and critically; prying information and insight from primary sources to better understand a given historical setting; and comparing sets of primary sources in different settings
- Through the study food access and preparation as a historical force, gain an understanding of key historical concepts, such as causation, chronology, sequence, and consequence, and their place in analyzing the interplay of change and continuity in Italian and Italian American culture.
Please contact the TCNJ Center for Global Engagement at email@example.com, 609-771-2596.
For course specific questions, please contact Cecilia Colbeth at firstname.lastname@example.com or Dr. Ann Marie Nicolosi at firstname.lastname@example.com
Please review our refund, cancellation, and withdrawal policy statement should a student not be able to participate in the program.


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Voyeur : December 2009
023 DECEMBERVOYEUR å HIT THE ROAD KNOW_IT_ALL_ TEXT :: CAMERON MCGAVIN LET THEM EAT CAKE THE NEW AUDI TT DIESEL GETS YOU FROM A TO B IN SPORTS-CAR STYLE WHILE EASING YOUR ECO-CONSCIENCE, SO YOU CAN HAVE YOUR CAKE AND EAT IT TOO. Try to have some fun these days and watch the wowsers erupt. Fast food makes you fat, as can that glass of wine, and you're not eco-conscious if you drive a performance sports car. Audi's new TT 2.0 TDI quattro, however, lets you have your cake and eat it too. It looks and drives like a sports car, but thanks to its diesel engine -- a first for series-production sports cars -- it's thriftier than most fuel-efficient green machines. Of course, the very thought of sullying a sweet-driving car with a slow-revving diesel engine will be considered heresy by some. But the TDI keeps petrol TTs honest. It's not quite as quick as the 2.0 TFSI models, but its 350Nm torque peak is 70Nm higher and occurs at lower revs. So, unlike the petrol versions, which need revs to feel truly perky, the diesel TT just hunkers down and goes when whipped, tapping into its rich seam of low-rev grunt. That means you get a better power response at lower speeds. The TT's fundamental fang-ability hasn't been diluted either. The handling is satisfyingly agile and the six-speed manual is a peach, while the all-wheel- drive system (quattro, in Audi speak) delivers real security you can depend on in slippery conditions. And it's no less desirable, with the same gorgeous exterior and comfy, beautifully appointed cabin as any TT. The back seat is cramped, but when folded down endows the car with impressive load-carrying abilities. The downsides? Well, with its 5,400rpm limit, the TDI lacks the spirited high-rev edge of its petrol siblings. But when you factor in its sensational 5.3L/100km economy, low CO2 emissions and enticing price (it costs $6,000 less than the all-but-identical 2.0 TFSI quattro), the TT 2.0 TDI quattro starts to look like a punt worth taking. UNDER THE HOOD Model :: Audi TT 2.0 TDI Engine :: Two-litre turbodiesel four-cylinder Power :: 125kW @ 4,200rpm Torque :: 350Nm @ 1,750rpm to 2,500 rpm Transmission :: Six-speed manual Fuel consumption :: 5.3L/100km Acceleration :: 0--100km/h in 7.5 seconds RRP :: From $70,900 (including GST)
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By Jim Corbett, USA TODAY
Arizona Cardinals all-pro wideout Larry Fitzgerald is always brainstorming new ways to chase greatness.
He outdid himself this offseason.
It wasn't enough for Fitzgerald, 25, to eclipse San Francisco 49ers legend Jerry Rice with his playoffs-record 30 receptions for 546 yards and seven touchdowns in the Cardinals' 2008 Super Bowl run. He decided this offseason to train with and learn from the former receiver, whom he considers the greatest ever.
PHOTOS: Cardinals training camp
So Fitzgerald convened a passing camp this summer at the University of Minnesota, inviting other young talented wideouts such as Green Bay Packers star Greg Jennings, the Denver Broncos' Brandon Marshall, the Minnesota Vikings' Sidney Rice and the Tampa Bay Buccaneers' Michael Clayton. Fitzgerald also invited his longtime mentor, Cris Carter.
Then he reached out to Rice, who agreed to join the camp for a week.
The only thing more impressive than Fitzgerald's remarkable postseason ascent was his ambitious offseason agenda. There's little concern about a post-Super Bowl letdown for the sixth-year wideout, who reinvented himself as a respected league-wide leader.
"My goal is to be a better player in every way possible and never let complacency set in," Fitzgerald says. "Don't ever lose sight of being the best, most dominant player. After every year, I evaluate the weaknesses in my game — the mental and physical. I called Cris Carter, who has been like an uncle to me.
"But I wanted the same type relationship with Jerry Rice, one of the greatest players to ever play the game and the greatest receiver ever to play. I wanted to see what made him tick."
And Rice showed Fitzgerald.
"Jerry Rice is 46 years old. Yet he did every single thing we did on that field. He worked like he was in training camp," Fitzgerald says.
"His dedication is off the charts. I was thinking, if I had the mental toughness Jerry Rice has at 46 at 25, where (would I) be in this game?"
Vikings Pro Bowl defensive end Jared Allen joined Fitzgerald on a March USO tour to Iraq and Afghanistan. Allen and Fitzgerald struck up a friendship and traveled to six more countries, an odyssey that included shark diving off the coast of South Africa and a safari.
"Larry's an absolute beast, and he's such a nice guy," Allen says. "He has a ton of respect around the league.
"There's certain players who are driven not by money or fame, but who want Super Bowls. We want to be remembered as some of the best players to play this sport in honor of the people who played before us.
"Larry's one of those guys."
Jennings, who led Green Bay with 80 catches for 1,292 yards and nine touchdowns in 2008, says: "Working at Larry's camp for two weeks really opened my eyes to how to work. As good as he is, there's so much humility in Larry."
The only thing Fitzgerald enjoys more than traveling to exotic new locations is saying thanks to the troops. Military service runs in his family beginning with his grandfather, who was awarded a Purple Heart as an Army lieutenant during the Korean War.
After the USO tour, Fitzgerald, Allen and recently waived Houston Texans fullback Boomer Grigsby went on a whirlwind tour, including a visit to the pyramids in Egypt and going on safari through a South African national park where Fitzgerald saw a leopard chase a wounded gazelle up a tree before killing its prey.
The scene taught Fitzgerald the mindset needed to finish a Super Bowl title quest. "We saw a leopard killing a gazelle; it put things in perspective," Fitzgerald says.
But Fitzgerald also maintains his perspective off the field.
"He's a great dude, and we struck up a great friendship," Allen says. "We have the same type of drive.
"I'm a peer-pressure son of a gun. But Larry out-peer-pressured me to go on that eight-country trip in 30 days.
"We went on four different safaris.
"We were in Dubai, Libya, Zambia, Zimbabwe, Egypt. We visited the middle of the great pyramid. He knows how to travel.
"And he has that internal drive where he wants to be dominant."
It would have been understandable if Fitzgerald took the month before training camp off to relax. Instead, he headed to the Cardinals' training camp in Flagstaff, Ariz., 10 days early to train at the 7,000-foot altitude.
Fitzgerald produced 96 regular-season catches for 1,431 yards and 12 touchdowns last season despite playing with torn cartilage between his middle and ring fingers and a broken left thumb.
Then, in Super XLIII, Fitzgerald's 64-yard, catch-and-run touchdown gave Arizona a 23-20 lead with 2:37 left in the game. That was before the Cardinals suffered a last-minute loss on Pittsburgh Steelers quarterback Ben Roethlisberger's touchdown pass to Santonio Holmes.
"The Super Bowl loss left a bad taste in my mouth," says Fitzgerald, who earned Pro Bowl MVP honors a week later.
"Last year's playoffs opened my eyes to what it's all about. This game is about team excellence."
Now just imagine what Fitzgerald might be capable of with two healthy hands.
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Exploring metazoan evolution through dynamic and holistic changes in protein families and domains
Proteins convey the majority of biochemical and cellular activities in organisms. Over the course of evolution, proteins undergo normal sequence mutations as well as large scale mutations involving domain duplication and/or domain shuffling. These events result in the generation of new proteins and protein families. Processes that affect proteome evolution drive species diversity and adaptation. Herein, change over the course of metazoan evolution, as defined by birth/death and duplication/deletion events within protein families and domains, was examined using the proteomes of 9 metazoan and two outgroup species.
In studying members of the three major metazoan groups, the vertebrates, arthropods, and nematodes, we found that the number of protein families increased at the majority of lineages over the course of metazoan evolution where the magnitude of these increases was greatest at the lineages leading to mammals. In contrast, the number of protein domains decreased at most lineages and at all terminal lineages. This resulted in a weak correlation between protein family birth and domain birth; however, the correlation between domain birth and domain member duplication was quite strong. These data suggest that domain birth and protein family birth occur via different mechanisms, and that domain shuffling plays a role in the formation of protein families. The ratio of protein family birth to protein domain birth (domain shuffling index) suggests that shuffling had a more demonstrable effect on protein families in nematodes and arthropods than in vertebrates. Through the contrast of high and low domain shuffling indices at the lineages of
Metazoan speciation and adaptation were explored by birth/death and duplication/deletion events among protein families and domains. Our results provide insights into protein evolution and its bearing on metazoan evolution.
Proteins convey the majority of biochemical and cellular activities in organisms. Their structural and functional units are defined as domains
Protein evolution has been explored for decades. Indels and substitutions have been linked to protein structure and function
The present investigation analyzed 9 metazoan proteomes covering the three major metazoan clades; vertebrates, arthropods, and nematodes, together with those of
Protein family birth and death
Protein families were constructed from all sequences representing 11 eukaryotic taxa using Markov Clustering (MCL;
Additional file 1
Data summary of the species included in the analysis. The data provided represent summary of the number of proteins and domains per species and proteins within protein families.
Click here for file
Additional file 2
IDs of protein families and their members. The data provided represent the accession numbers of the proteins grouped in protein families.
Click here for file
Additional file 3
Groups of protein families with different taxonomic compositions. The provided table summarizes the numbers of protein families and their taxonomic distribution.
Click here for file
Duplication and deletion in universal protein families
We selected 804 universal protein families containing members present in all 11 taxa and investigated duplications and deletions among the members. Focusing on universal families helped minimize the effects of species adaptation and detect signals associated with genomic evolutionary events. Six universal families were excluded because large numbers of sequences (more than 1,000) in those families prohibited further multiple sequence alignment and tree building. Of those examined, 12,507 duplications and 22,954 deletions were inferred, averaging 16 duplications and 29 deletions per family. In the majority of lineages, deletions outnumbered duplications; however, at the LCA of nematodes, deletions were 28 times greater than duplications suggesting protein families became smaller (Table
Domain birth and death
We successfully identified 5,106 domains from 123,084 proteins. Unlike protein families where less than 5 percent were universal (810 out of 17,752) and more than 20 percent were species specific, more than 20 percent of domains (1,172 out of 5,106) were universal and less than 6 percent were species specific (Table
Birth/death events of the 5,106 identified domains were inferred in the same manner as protein family birth/death events (Table
Additional file 4
Click here for file
Domain duplications and deletions
Similar to family member duplications and deletions, domain duplications and deletions were analyzed for each phylogeny. For the purpose of comparability, only the 1,168 universal domains (domains present in all 11 species) were considered. In total, 49,958 duplications and 94,648 deletions were inferred for the universal domains; 5 domains were excluded because they have more than 1,000 members. As observed among universal protein family members, domain duplication and deletion varied substantially over the course of evolution, and sister lineages did not have similar numbers of duplications and deletions (Table
Correlation between protein domain evolution and protein family evolution
Pearson's correlation coefficients were used to investigate the relationship between domain evolution and protein family evolution (Table
Dynamic evolutionary changes over the phylogeny
Reconstructed birth/death events within protein families and domains provided opportunities to better understand evolution and adaptation. Over evolution, changes in the number of protein families differed from those of protein domains. As shown in Figure
Figure 1
Protein family and protein domain change indices.
Protein family and protein domain change indices. At each lineage, the index for protein family change is followed by that of domain change (separated by back slash '/'). The index for protein family change was calculated using the log ratio of protein family birth and death events reconstructed from 17,752 homologous multimember families (151,044 proteins), thus representing how changes in protein families at any given lineage favor family gain or family loss. The index defining the change in protein domain complexity was calculated using the log ratio of protein domain birth and death events reconstructed from 123,084 proteins (5,106 domains). Analogous to protein family change, this represents how domain changes at any given lineage favor domain gain or loss.
Given the lack of correlation between protein family and domain changes at all lineages, results suggest that domain shuffling played a large role in the formation of new families. To measure this effect we calculated the domain shuffling index i.e., the log ratio of protein family birth to protein domain birth, for each lineage (Figure
Figure 2
Domain shuffling indices associated with the lineages over metazoan evolution.
Domain shuffling indices associated with the lineages over metazoan evolution. The indices are the log ratio of protein family birth and protein domain birth events inferred in the corresponding lineage.
Complexity changes and domain shuffling indices did not inform us on temporal issues related to organism adaptation during evolution. To this end, we utilized the summation of the logarithm of protein family birth events and protein family death events normalized by lineage branch lengths as an adaptation index to define the speed of adaptation at the various lineages (Figure
Figure 3
Adaptation indices associated with metazoan lineages.
Adaptation indices associated with metazoan lineages. The indices were the summation of the logarithm of protein family birth events and death events, inferred at the corresponding lineages, normalized by the branch length of the lineage.
Domain shuffling and protein family formation
The above data suggest that domain shuffling has a strong impact on protein family complexity and organism adaptation. Consistent with this, a large number of domains of newly generated families were identified from existing domains. Figure
Figure 4
Distribution of protein domains among the protein families at the last common ancestor (LCA) of each of the three metazoan groups and the universal families.
Distribution of protein domains among the protein families at the last common ancestor (LCA) of each of the three metazoan groups and the universal families.
Figure 5
A putative format for generating the vertebrate specific protein structure of PHD finger protein 3 (Cluster3894).
A putative format for generating the vertebrate specific protein structure of PHD finger protein 3 (Cluster3894). The domain structure of PHD finger protein 3 was formed through domain shuffling between universal families, transcription elongation factor A (Cluster1010) and histone acetyltransferase (Cluster330), followed by the addition of a new functional domain.
Functional adaptation
The functions of families born at the LCAs of the three major clades and those born at the LCA of metazoans were investigated by biological process GO term enrichment/depletion. The GO terms enriched/depleted in these families closely align with adaptation of the species (Table
The functional association of family deaths at the LCAs of nematodes, arthropods, and vertebrates were also investigated through biological process GO term enrichment (Table
Duplication of whole genome, protein families and domains
As stated earlier, two family/domain duplication bursts were observed at the LCAs of metazoans and vertebrates. In order to evaluate the effects of whole genome duplication on these two bursts, the numbers of universal families/domains involved in duplications and/or deletions at these two LCAs were examined (Figure
Figure 6
Protein families (A) and protein domains (B) exhibiting duplication and/or deletion at the last common ancestor (LCA) of metazoans and at the LCA of vertebrates (bold).
Protein families (A) and protein domains (B) exhibiting duplication and/or deletion at the last common ancestor (LCA) of metazoans and at the LCA of vertebrates (bold). The numbers of protein families and domains without any duplication or deletions are at the upper left corner.
This work provided a systematic analysis of both protein family evolution and domain evolution at the genomic level. Related evolutionary events were reconstructed and analyzed using proteomes from nine metazoan species via a variety of evolutionary and statistics programs. We included three well-annotated species,
Lineage specific protein family and domain evolution
Both birth/death and duplication/deletion of proteins and their domains vary substantially between lineages. We characterized these variations through four measurements; the log ratio of protein family birth and death (protein family change index), the log ratio of protein domain birth and death (protein domain change index), the ratio of protein family birth and protein domain birth (domain shuffling index), and the summation of logarithm family birth and death events normalized by branch length (adaptation index). Indices defining protein family and domain changes reflect family and domain gain or loss at different lineages, and represent changes in complexity of the organism's proteome at each lineage. Domain shuffling index is a good indication for the effects of domain shuffling at any given lineage. The adaptation index illustrates how quickly adaptation occurred through protein family birth/death among the lineages during evolution. These measurements provided an interesting representation of metazoan, lineage-specific evolution.
Our study revealed a consistent increase in complexity during the evolution of vertebrate mammals from the perspective of protein families as illustrated by the positive change in the protein family and domain indices at the corresponding lineages. These data corroborate prior work on Pfam protein domains showing large increases in complexity among Metazoa where high rates of new domain formation and changes in domain architecture were observed
Meanwhile, terminal lineages uniformly exhibited reductions in domain complexity while more than half of them showed increases in protein family complexity (Figure
Aside from variations in complexities and the effects of domain shuffling, adaptation speed appears much less variable as represented by the more consistent adaptation indices in the different lineages (Figure
Adaptation, and protein family and domain evolution
Our adaptation index derived from protein family birth and death did not reveal significant differences among the lineages studied. However, the differences in the numbers of protein and domain birth/death events and family member duplication and deletions in the lineages studied (Table
Functional enrichment of protein family births/deaths at the LCAs of the nematodes, arthropods, and vertebrates, and protein family births at the LCA of metazoans provide direct evidence for an association between species adaptation and protein evolution. Not surprising, protein families born at the LCA of metazoans were significantly enriched in functions related to regulation of transcription, multicellular organismal development, and signaling pathways, among others. These functional enrichments revealed the importance of the relevant families in the adaptation of metazoans while validating our family reconstruction. The most significant of enrichments, the regulation of transcription, is clearly reflective of the critical role this function plays in metazoan adaptation
Besides the signaling pathway involving the G-protein-coupled receptor, other families born at the LCA of nematodes with significant functional enrichment include the trehalose biosynthetic process, cation transport, and cell wall catabolic process. Trehalose may be used as a compatible solute to contend with osmotic stress or as an external carbon source
Whole genome duplication and burst of protein family/domain duplication
Despite the variation in protein family, and domain death/birth events, bursts of duplications were observed at the LCA of metazoans and at the LCA of vertebrates. The source for these bursts is not known, but whole genome duplication has been suggested for vertebrates and yeast
Although the evolution of protein families and domains has been a research topic for some time, the current study is the first to closely investigate both duplication and birth/death rates for protein families and domains using a well-balanced and extensive data set. By reconstructing the evolution of protein families and domains over lineages that span the Metazoa which included all three major groups and multiple species within each group, for the first time we were able to quantify the relationship between protein family evolution and domain evolution, and examine the effects of domain shuffling in a lineage specific manner. By revealing the strong positive correlation between domain birth and duplication, we provided evidence for the evolutionary role of functional redundancy. By demonstrating a weak correlation between protein family birth and member duplication (in combination with the close correlation of the same events of domains), our analyses provided direct evidence for domain shuffling.
Additionally, we investigated not only new proteins that emerged (born) throughout evolution, but also proteins that disappeared (died) over this same period. This provided insights into understanding organismal adaptation, such as parasitism. To our knowledge, this is the first systematic study exploring adaptation through the death or disappearance of proteins. Finally, by examining both protein family and domain duplications, we provided strong evidence for whole genome duplication at the LCA of the Metazoa.
In conclusion, we studied metazoan evolution at a proteome level using a phylogenetic approach. Metazoan speciation and adaptation were explored by birth/death and duplication/deletion events among protein families and domains. The results characterized metazoan lineage-specific evolution related to protein families and domains. Despite the large variation, lineages leading to mammals exhibited consistent increases in protein family complexity during evolution. Results also illustrated that domain shuffling had a greater impact on protein family complexity in nematodes than in other metazoans, and that protein redundancy may be critical for evolutionary changes controlled by domain shuffling. By relating the evolutionary events to the functions of the proteins/domains involved, the results exposed the adaptive roles of these events. Overall, our study provides new insights into protein evolution associated with metazoan speciation.
Data collection
Whole proteome data from 9 metazoa were collected. The datasets were comprised of 3 species of vertebrates, 3 species of arthropods, and 3 species of nematodes. Data were downloaded as follows:
Protein family reconstruction
Protein sequences from the 11 species were searched (BlastP) against each other. Based on these results, we used MCL
Domain identification
Each protein sequence was searched against the PFam domain profiles
Duplication and deletion detection
Duplications and deletions of protein sequences and domain sequences were identified using Urec
Protein family and domain death and birth
Using an approach similar to that of Hughes and Friedman
Protein family deaths and births were inferred by checking the states of these characters on each lineage of the 11 species tree. In a like manner, the death/birth events of each domain over its evolution were also inferred as were the unique domain losses of each species. Unique domain losses were defined as deaths of domains present in all other 10 species except the one indicated. The association of family member duplications/deletions, domain duplications/deletions, protein family deaths/births, and domain deaths/births were investigated using Pearson's correlation coefficients. The significance of these correlation coefficients was tested using Student's t-distribution.
Indices defining protein family and domain change, adaptation, and domain shuffling
Organism complexity is closely related to the number of protein families and domains. In order to illustrate the changes of organism complexity over the course of evolution, we computed the log ratio of birth and death events of protein families and domains at different lineages, which we define as protein/domain change index. For example, if the number of birth events equals that of death events over a lineage, the index is 0, suggesting no complexity change over the evolution of this lineage. If the number of birth events is larger than death events, the index is larger than 0, suggesting the organism has gained complexity over the lineage.
The protein family and domain change indices reflect the changes of organism complexity, but does not reflect how quickly these changes occur. To assess the spread of these changes, we used the following equation:
where AI: Adaption Index; B: inferred birth events at the corresponding lineage; D: inferred death events at the corresponding lineage; l: the branch length of the corresponding lineage. If the branch length of a lineage is short and possesses a large number of birth/death events, then the adaptation index of that lineage is large, suggesting dramatic adaptation along that lineage. Only adaptation index of protein family was explored because of the limited number of domain birth events.
Protein families can be generated from new domains and/or domain shuffling. To illustrate the effect of domain shuffling in protein family evolution, we examined the log ratio of protein family birth to protein domain birth at different lineages which we defined as the domain shuffling index. Similar to the adaptation, index, the birth events were first normalized by the lineage branch lengths.
Functional examination
GO term functional annotation of protein families was examined using Interproscan
FDR: False discovery rate; GO: Gene Ontology; LCA: Last common ancestor.
Competing interests
The authors declare no competing financial interests.
Author's contributions
ZW, DZ and MM designed the study and wrote the manuscript. ZW, SA, and JM did the analysis. All authors read and approved the final manuscript
This work was supported in part be the NIH NIAID grant AI081803 to M.M.
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Phylogenetic and evolutionary analysis of the septin protein family in metazoan
Nematode genome sequence dramatically extends the nuclear receptor superfamily
The Caenorhabditis globin gene family reveals extensive nematode-specific radiation and diversification
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Current topics in genome evolution: Molecular mechanisms of new gene formation
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Domain shuffling and the evolution of vertebrates
The evolution of protein domain families
An efficient algorithm for large-scale detection of protein families
Role of Horizontal Gene Transfer in the Evolution of Plant Parasitism Among Nematodes
Quantification of the Elevated Rate of Domain Rearrangements in Metazoa
The Evolutionary Fate and Consequences of Duplicate Genes
Genome Size Reduction in the Chicken Has Involved Massive Loss of Ancestral Protein-Coding Genes
Evolution of domain promiscuity in eukaryotic genomes–a perspective from the inferred ancestral domain architectures
Sequence and genetic map of Meloidogyne hapla: A compact nematode genome for plant parasitism
The nuclear receptor superfamily
Initial sequencing and analysis of the human genome
Evolution of new protein topologies through multistep gene rearrangements
Modeling the Evolution of Protein Domain Architectures Using Maximum Parsimony
Relative rates of gene fusion and fission in multi-domain proteins
Evolution of the Vertebrate Genome as Reflected in Paralogous Chromosomal Regions in Man and the House Mouse
Recent acceleration of human adaptive evolution
The role of lineage-specific gene family expansion in the evolution of eukaryotes
Duplication and divergence: The evolution of new genes and old ideas
Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution
Genesis and expansion of metazoan transcription factor gene classes
The unicellular ancestry of animal development
Evolution of key cell signaling and adhesion protein families predates animal origins
The dawn of developmental signaling in the Metazoa
Ancestry of neuronal monoamine transporters in the Metazoa
Neurobiology of the Caenorhabditis elegans genome
The olfactory receptor gene superfamily of the mouse
On the Origin and Evolution of Vertebrate Olfactory Receptor Genes: Comparative Genome Analysis Among 23 Chordate Species
Acyl-CoA Dehydrogenases: Dynamic History of Protein Family Evolution
Patterns of Positive Selection in Six Mammalian Genomes
Characterization of TreR, the major regulator of the Escherichia coli trehalose system
Physiological roles of trehalose in bacteria and yeasts: a comparative analysis
Molecular and genetic characterization of osmosensing and signal transduction in the nematode Caenorhabditis elegans
Lack of herne synthesis in a free-living eukaryote
Evolution of the Rho family of Ras-like GTPases in eukaryotes
Littlewood: Nematoda: Genes, genomes and the evolution of parasitism. In Adv Parasitol
Chromatin diminution in the parasitic nematodes Ascaris suum and Parascaris univalens
High mutation rate and predominance of insertions in the Caenorhabditis elegans nuclear genome
Protein Family Expansions and Biological Complexity
Proof and evolutionary analysis of ancient genome duplication in the yeast Saccharomyces cerevisiae
Evolutionary patterns of gene families generated in the early stage of vertebrates
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Evolution of the metazoan protein phosphatase 2 C superfamily
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The Genome Sequence of Caenorhabditis briggsae: A Platform for Comparative Genomics
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PHYLIP-Phylogeny inference package (Version 3.2)
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Differential loss of ancestral gene families as a source of genomic divergence in animals
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In this work of sensual erotica that defies description, Isabel is set to be wed. She goes for a walk with her friend, confessing about her hesitance to take the step, when she is suddenly lifted into the air and kidnapped by an old, giant tree - the mother tree.
The mother tree begins to swallow her, but soon finds that stimulating this girl sexually will bring way more nutrition to her roots and the earth. What follows is a dubcon submission fantasy in which Isabel's deepest fantasy comes true: that of being a submissive to a dominant force.
Content Warning: Taken by the Tree contains supernatural and paranormal sexual situations with mind control, dubious consent, and fantasy fulfillment. It is meant for adults only.
©2012 Sonia Robinson (P)2012 Sonia Robinson
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Friedrich Julius Stahl Items17 textbooks were found
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The Premadasa Stadium is named after a former president of the country Ranasinghe Premadasa and can hold up to 40,000 people and only hosted its maiden ODI (between Sri Lanka and New Zealand) 1996.
It remains the only ground in Sri Lanka with permanent floodlights, a key factor that enabled it to host the ICC Champions Trophy final in 2002/3.
Although primarily an ODI venue it has also held five Tests. Memorably, one of those was against India in 1997/8 when Sanath Jayasuriya scored 340 out of Sri Lanka's mammoth 952-6 declared.


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|Home > Justo
♂ Justo
What does Justo mean?
Justo [jus-to] as a name for boys is of Latin origin, and Justo means "just, upright, righteous". Justo is a version of Justin (Latin): variation of Justus.
ASSOCIATED WITH just
OTHER FORMS VIA JUSTIN Giusto, Joost, Just, Justain, Justan, Juste, Justen, Justino, Justis, Justus▲, Justyn▼CREATIVE FORMS
(male) Jesto, Joto, ..
(female) Jusma, Jusna, .. MIDDLE NAME PAIRINGS
Justo Laken (J.L.), ..
How popular is Justo?
Justo is an unusual given name for men but a very prominent surname for all people (#23300 out of 150436, Top 15%). (2000 U.S. CENSUS)
Justo entered the list in 1890-1899 and reached its top position of #1848 in the U.S. in the 1960s, but is not listed currently. (TOP BABY NAMES, 2015)
Which version is better?with its source form and related boy names. Justen, Justin (#110 THE PREVIOUS YEAR), Justis, Justus (#866) and Justyn are the prominent related forms of Justo. Usage of these relations of Justo was at its peak 4 decades ago (MEDIAN #1291) and has become much less since (#1496, 87% LESS USAGE), with versions like Justyn becoming less stylish. Justus is the most fashionable baby name among these.
Similar NamesSuggested similar names are Fausto, Guto, Jeston, Julio, Junio and Sesto. These names tend to be more commonly used than Justo.See names in meaning and etymology.


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Dr. Dirbas is AMAZING!! Thoughtful, caring, kind and compassionate, Dr. Dirbas spends a lot of time with each patient, answering questions and addressing concerns, ... Read more
Dr. Ganjoo is an angel. I thank God everyday for her brilliance & compassion.
Dr. Arai is an amazing oncologist! Her brilliant mind, wealth of knowledgeable, and dedication to medicine and her patients are extraordinary. She provides highly... Read more
It is a bit like seeing a grandfather, the wait time is now 1.5 hours. With only minor presence in the clinic, expect long and slow response to very basic questions... Read more
We felt pressured to do a bone marrow transplant. She did not prepare us for complications. She keeps saying everything will be ok, when it is not. Rushed. Not a... Read more
I don`t recommend this doctor! He is not thorough and is good only for basic diagnosis...and not friendly.
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Business Law
Ask a Business Lawyer. Get Business Law Questions Answered ASAP.
failure to pay dues, fees, etc in a timely manner
The Club has continued billing me each month for $1200 AFTER the expiration of the one year, which is contrary to their bylaw. I am still delinquent with my dues.


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featuring: João Gilberto, Erykah Badu x Major Lazer x MØ, Justin Timberlake, Drake and ABBA
covered by: Azealia Banks, Leo Kalyan, Cryface Jordan, Different Sleep and Portishead
featuring: João Gilberto, Erykah Badu x Major Lazer x MØ, Justin Timberlake, Drake and ABBA
covered by: Azealia Banks, Leo Kalyan, Cryface Jordan, Different Sleep and Portishead
We catch up with Hermitude ahead of the St Jerome's Laneway festivals
by Tanya Bonnie Rae
Experimental pop duo Leyya talk about their sound, musical inspiration and their killer new music video
– by Tanya Bonnie Rae
HÆLOS release their new EP this week and share it's mesmerizing new single
German duo Hotlane introduce us to their infectious electro-pop sounds
Leyya's Spanish Disco is an enigma wrapped in an enigma
– ★★★★☆ by Tanya Bonnie Rae
Take a listen to this very impressive new track from a 19 year old Sydney newcomer called, Violet
Moby returns with an interesting and eclectic album that features guests including Wayne Coyne, Inyang Bassey and Cold Specks. ★★★
Charli XCX meets Portishead via London-based songstress and producer Twigs. Her new, eerily seductive track 'How's That' was co-written and produced by New York's Arca.
Yolanda Be Cool recalled 'We No Speak Americano' to make way for debut record 'Ladies & Mentalmen.' We spoke to Sylvester Martinez, one half of the Bondi Beach duo. The record, Pitbull, and threesomes were hot topics.
Last year, we witnessed the birth of Harvest, A Civilised Gathering, which came to us with with a slew of outstanding acts like TV on the Radio, The National, Portishead and The Flaming Lips. Harvest Festival is returning to Sydney, Melbourne and Brisbane in 2012, taking place between November 11 and 18. In tow is another stellar line up: Beck Sigur […]
American indie-rock group Clap Your Hands Say Yeah (CYHSY) are hitting our shores this November for the inaugural HARVEST music festival. They'll be playing alongside heavy weights The Flaming Lips, The National, Portishead & TV on the Radio. To promote latest LP Hysterical, the guys will be doing a few sideshows while in the country. We happen to have a double pass […]
Coming to Australia this summer from the team that brought you Soundwave, comes brand-spanking new festival Harvest: A Civilised Gathering. It is set to be a one day outdoor music and arts festival taking place this November in Melbourne, Sydney and Brisbane offering a world class line-up catering to a tidy 15,000 to 20,000 capacity. Check out the epic […]


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- Joseph Garcia is a Liberal political figure and deputy leader in Gibraltar, see Joseph Garcia. The Gibraltar Liberal Party of Garcia is genuinely liberal. They emphasize freedom, equality, equal opportunity in education and elsewhere. The The Gibraltar Liberal Party emphasizes private enterprise and free markets, with limited regulation. This contrasts with Social Democrats who tend to favour Regulated markets and collective responsibility.
- A different Joseph Garcia is a notorious American criminal and Jailbird who escaped and was recaptured, see Texas Seven
Can you imagine what it's like to be dying in some dirty place with cockroaches biting you while you are still alive? I can't -- though Scientologists let Lisa McPherson die that way. If you've the stomach for them here's the Autopsy photos.
We regret that Wikia put Scientology advertisements onto some of our pages, this happened more a few years ago. We hope the advertisements were completely useless.


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Thanks for helping us associate the correct Pornstars to this video!
Помогите нам: эти порнозвезды присутствуют в этом видео?
Pornstar Name:
I have same outfit but black and love fucking with it on hearing the chains, would love two gorgeous cocks like this pumping me
gdadl must not have watched this. she takes cock like a pro that at least "acts" like she likes it. she is better than anything you've ever had and you know it
What's her name?
o yeah
itz so wonderful
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- Description
Crown Mark Merlot Traditional Buffet and HutchIncludes
1 Buffet and 1 HutchDimensions
Buffet(2145-B), 52X17X32"H
Hutch(2145-H), 52X17X48"H
More from this collection: Merlot
- Additional Information
Additional Information
SKU 15901433 MPN 2145-B+2145-H GTIN N/A Brand Crown Mark Collection Merlot Assemble Length No Assemble Width No Assemble Height No Assembly Required Yes Material Wood Finish No Styles Traditional Shipping Time 1-2 Weeks Free Shipping No
- Reviews
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