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- all night man
- obsolete Britisha dealer in corpses• He took newly buried corpses for sale to teaching hospitals, especially in Scotland.There was no property, or ownership, in a corpse and a paucity of donors who were fearful of a piecemeal return to earth of themselves or their relatives at the expected Resurrection of the Dead.See also resurrection man.
How not to say what you mean: A dictionary of euphemisms. R. W. Holder. 2014.


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on After Effects, Final Cut Pro, AVID and much more.
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We take a look at 5 of the latest high speed capable cameras – and share a quick video tutorial on working with high speed effects in post production.
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WARNING: Proceed reading this rant only if you're matured, aware of some socio-political issues in Malaysia, and non-judgemental. Reading this with closed minds will get you nowhere. Comments like 'Sabar, sabar' and anything political will be disregarded
My degree years are finally, finally, over. It was a long journey, but I made it. I'm 23, and I'm done with my degree. I hope I can do my masters soon, but there are things I must accomplish before that. Dreams are important. Reality, however, must always take precedence.
I am not the type of person who thinks about migrating and working overseas. The Malaysian system won't cripple me much, so most of the time I'm not comfortable with talks about breaking away once the teaching contract is over. This country didn't kill me while I was growing up. Something must be right somewhere. The only thing that teaching in Malaysia disappoints me is the placement part. Don't even try to argue this shit with me; we all know how hard it is for teachers who are either born or live in Kelantan to get posted to Kelantan. We are always fed with shits about 'There's no more place in Kelantan. All full.'
Explain the lack of teachers in my schools back in the years when I was still young. Hello. My house is surrounded by many schools that lack teachers. Words get around, and still they say it's full? All of the time, I heard people grumbling "Because Kelantan is governed by the opposition party, so the central wants to teach them a lesson" blablabla crap. When you ask for transfers, you need cables. Families and friends always come first. Complete, utter, political bullshit. Bureaucracy. Professionalism? Floating in the drain most of the time, maybe.
Personally speaking, I don't want to teach in Kelantan for some reasons (not political, thank you very much. I hate that stuff). I'm making sacrifices because of my mother, who's now old and always down with sickness. I'll have years ahead of me, InsyaAllah, but my parents are old. There's only myself and my two brothers. My parents are both above 60 years old, only have three children, and only ONE daughter, so is it too much to ask for when we hope to get posted somewhere nearby so we can check up on them always?
Seriously, people don't feel anything if it doesn't happen to them. Empathy is lost, I suppose.
I don't remember the name of this one official from the education division, but she said she was involved in placement (as told by her in her super long speech). She told stories about how this one woman requested to get posted near her parents' house, and when she finally got posted (by asking that official personally), she only got to spend a little time before her mother passed away. Would the female teacher get her transfer if she had only applied for transfers the normal way (aka the paper system)? Meh, don't think so.
My brother has been applying for transfer, and his application has always been rejected. Just very recently, 6 of his friends' transfer requests were approved. Not to Kelantan, OF COURSE.
So, full huh? I want full statistics, complete with school names, staff list, fields of practice and divisions of work. That's how they can redeem themselves in my head.
Peace, out.


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This new dance tune from PJU and Javi will have your Wednesday feeling like a Friday
Tag Archives: Punks Jump Up
PJU team up with London's River for a great new housey treat
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If things ever start to look like this, you've had way too much…
The Penelopes return with their first mixtape for the year, Chart February 2014
The Penelopes deliver their final collection of disco party tunes for the year, Charts December 2013
We love you long time.
Kick start your Monday with REFLEX's Mixtape #19. Jam-packed with disco, summer delights from around the globe.
Say hello to the weekend.
Dance, and get wet.
This will be the soundtrack to a whole lot of sinning.
You don't touch disco; disco touches you.
Shake it all about.
"I know you want to do it, you know I want to do it too. Out there on the dance floor, we can make sandwiches."
We want to make you sweat. Sweat till you can't sweat no more.


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The National Association of Securities Dealers Automated Quotation, NASDAQ is the second largest Stock Exchange in the USA. Involves many of the US's high technology stocks.
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Sanbir Dutta is a guru on the HBO original series True Blood. Played by Indian-American actor Shishir Kurup, Sanbir makes his debut on the episode "Fire in the Hole" in the series' seventh season. Playing a recurring role through the same season, Sanbir is the proprietor of an ashram called the Institute for the Unchained Spirit in Los Angeles, California. A lover of Sarah Newlin, Sanbir met an untimely demise in the Season 7 episode "Karma". He appears once more, in one of Sarah's hallucinations, on the subsequent episode, "May Be the Last Time", in the series' seventh, and final, season.
Physical AppearanceEdit
Sanbir Dutta was a self-styled guru and proprietor of the Institute for the Unchained Spirit, an ashram which primarily operated as a yoga studio. He was a practitioner of Buddhism and tantric sex.
Season 7Edit
When Sarah Newlin went on the lam after the vampire revolt at the Burrell camp, she searched for a place where nobody would recognize her. She read about the ashram, and made her way to Los Angeles to join. Guru Dutta took Sarah, now calling herself Noomi, into his home and she quickly became his star student and lover. ("Fire in the Hole")
When the Yakuza tracked Sarah to Guru Dutta's establishment, he was ambushed by Hiroki and questioned about Sarah's whereabouts. Knowing that she was in his wine cellar, Sanbir admitted that he knew Sarah, but refused to tell Hiroki where she was. For this, he was decapitated by the Yakuza. ("Karma")
Sanbir later appeared as one of Sarah's hallucinations of her former lovers to taunt her for having cost him his life. ("May Be the Last Time")
|Season seven appearances
|"Jesus Gonna Be Here"
|"I Found You"
|"Fire in the Hole"
|"Death is Not the End"
|"Lost Cause"
|"May Be the Last Time"
|"Almost home"
|"Love is to Die"
|"Thank you"


text:
EmmaCortez Model
Brandon E CarrModel Male Los Angeles, California, US
My MM URL: http://www.modelmayhem.com/brandonecarr
Mayhem # 1048411
About Me
As you can tell from looking at my photos, it's been a while since I've had any type of shoot. I was in a motorcycle accident a while back, and I ended up laying in a bed for about 6 months, and atrophy turned me into a depressed bean pole. After I got out of bed, I started eating terribly and became a depressed fat kid. It hasn't been until now that I'm back in shape and ready to shoot again. Willing to take on just about any test shoots you have to throw at me. I'd like to delete all the old photos I have up and and start a new. Use me as you see fit!
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$35.00 1 year ago
1985 Dodge D150 Or Ramcharger Grill - $35 (East Berlin)
For sale is a grill for a 1985 Dodge D150 or Ramcharger. It is in nice condition with no damage. First $35.00 cash gets it. Call between 10:00 AM and 10:00 PM. Please do not email I will not respond.
1 year ago
York, PA


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Bayesian probit regression model for the diagnosis of pulmonary fibrosis: proof-of-principle
The accurate diagnosis of idiopathic pulmonary fibrosis (IPF) is a major clinical challenge. We developed a model to diagnose IPF by applying Bayesian probit regression (BPR) modelling to gene expression profiles of whole lung tissue.
Whole lung tissue was obtained from patients with idiopathic pulmonary fibrosis (IPF) undergoing surgical lung biopsy or lung transplantation. Controls were obtained from normal organ donors. We performed cluster analyses to explore differences in our dataset. No significant difference was found between samples obtained from different lobes of the same patient. A significant difference was found between samples obtained at biopsy versus explant. Following preliminary analysis of the complete dataset, we selected three subsets for the development of diagnostic gene signatures: the first signature was developed from all IPF samples (as compared to controls); the second signature was developed from the subset of IPF samples obtained at biopsy; the third signature was developed from IPF explants. To assess the validity of each signature, we used an independent cohort of IPF and normal samples. Each signature was used to predict phenotype (IPF versus normal) in samples from the validation cohort. We compared the models' predictions to the true phenotype of each validation sample, and then calculated sensitivity, specificity and accuracy.
Surprisingly, we found that all three signatures were reasonably valid predictors of diagnosis, with small differences in test sensitivity, specificity and overall accuracy.
This study represents the first use of BPR on whole lung tissue; previously, BPR was primarily used to develop predictive models for cancer. This also represents the first report of an independently validated IPF gene expression signature. In summary, BPR is a promising tool for the development of gene expression signatures from non-neoplastic lung tissue. In the future, BPR might be used to develop definitive diagnostic gene signatures for IPF, prognostic gene signatures for IPF or gene signatures for other non-neoplastic lung disorders such as bronchiolitis obliterans.
Pulmonary fibrosis is a significant cause of morbidity and mortality worldwide
An accurate diagnosis of pulmonary fibrosis requires the integration of clinical, radiographic and pathologic information
Bayesian probit regression (BPR) is a statistical method, well-suited to the analysis of highly dimensional data such as that produced by gene expression profiling. In the past, BPR was used to model differences in gene expression detected in cases of prostate cancer and ovarian cancer
The experiments described herein were designed as a proof-of-principle for the concept of "developing IPF gene expression signatures with BPR". Our aims were to develop a provisional diagnostic model for IPF; and to establish BPR as an appropriate method for developing additional gene signatures for non-neoplastic lung disease.
Ethics Statement
This study was approved by the Duke University Health System Institutional Review Board (IRB # Pro00007903, Pro00008725 and Pro00008819) and written informed consent was obtained from all subjects.
Study Population
We selected consecutive patients with IPF. Specimens were collected from 11 patients. All cases fulfilled multidisciplinary diagnostic criteria described in the American Thoracic Society/European Respiratory Society consensus statement
Samples of whole lung tissue were obtained at the time of diagnostic surgical lung biopsy (6 cases) or during orthotopic lung transplantation surgery (5 cases). Specimens were collected from both the upper and lower lobes whenever possible (6 out of 11 cases).
Control specimens (6 cases) were obtained from donated organs that were accepted for lung transplantation. At the end of lung transplant surgeries, we collected a portion of the newly transplanted lung that was removed during the process of routine lung volume reduction.
Sample Processing
Samples were immediately processed following removal from the body. First, specimens were cut into small pieces (< 5 mm in diameter), immersed in RNAlater solution (Ambion, Inc., Austin, TX) and incubated overnight at 4°C as per the manufacturer's instructions. Next, the supernatant was removed and samples were stored in a -20°C freezer.
At a later date, frozen RNA-protected samples were homogenized with a FastPrep device by using Lysing Matrix A (MP Biomedicals, Solon, OH). Total RNA was extracted from the homogenates by using RNAqueous-4PCR kits (Ambion, Inc., Austin, TX) as per the manufacturer's instructions. RNA quantity was measured with a spectrophotometer and RNA quality was assessed with a bioanalyzer (Agilent Technologies, Santa Clara, CA).
Isolated RNA was used to produce labeled-cRNA. Then labeled-cRNA was hybridized to Affymetrix Human Genome U133 Plus 2.0 GeneChips; and scanned using standard Affymetrix protocols. Our complete dataset is available through the Gene Expression Omnibus database (
Validation Cohort
The dataset for the validation cohort was accessioned from the Gene Expression Omnibus (
Statistical Analysis
Data processing
Expression estimates for the Affymetrix U133 Plus 2.0 GeneChips were obtained by robust multi-array average (RMA) then log2 transformed
Unsupervised cluster analysis
Global patterns of gene expression were evaluated (with the top 10% of genes by coefficient of variation) by Principal Component Analysis (PCA) and hierarchical clustering algorithms using the average linkage of the Pearson correlation coefficient.
Differential gene expression
Paired t-tests were used to assess differences in gene expression between upper and lower lobe samples. Unpaired Student's t-tests were used to compare the gene expression from IPF biopsies and IPF explants.
Supervised classification
Multi-gene models for binary phenotypes were derived using singular value decomposition (SVD) and Bayesian probit regression models, as described previously
Additional file 1
Supplemental Methods. Complete summary of the statistical methods and data integration steps used to develop and validate the multi-gene models.
Click here for file
Additional file 2
Model Selection (Figure S1). In order to optimize the fitted models for IPF Biopsies and IPF Explants, (A) and (C) the total sum of deviance was calculated for the observed phenotype versus posterior probabilities, and (B) and (D) the misclassification rate was computed under leave-one-out re-sampling for model sizes from 50 to 250 genes.
Click here for file
To independently validate the multi-gene models, features were mapped on a many-by-many basis between the training dataset (Affymetrix HGU133 Plus 2.0) and GSE10667 dataset (Agilent-014850 Whole Human Genome 4 × 44K Microarray) using Unigene and RefSeq IDs (Additional files
Additional file 3
Mapping the
Click here for file
Additional file 4
Mapping the
Click here for file
Additional file 5
Mapping the
Click here for file
Computational Software
All microarray pre-processing, BPR modeling and analyses were performed using R version 2.9 and Bioconductor packages designed for use with Affymetrix microarray data (Additional file
Additional file 6
Software codes in the R programming language (Bioconductor). Includes the algorithm for Bayesian Probit Regression. These codes are written for a specific machine. Please contact the authors for instructions on how to run these codes on another machine.
Click here for file
Demographic and physiologic characteristics of the 11 patients enrolled in this study are reported in Table
Table 1
Study Population
Patient Number
Sample ID
Sample Type
Multiple Lobes Sampled?
FVC% = forced vital capacity (expressed as a percentage of the normal expected value); DLCO% = diffusion capacity for carbon monoxide (expressed as a percentage of the normal expected value).
Global Analysis of Gene Expression
To explore gene expression differences (and similarities) between all of the samples, we carried out an unsupervised hierarchical cluster of the entire dataset (Figure
Figure 1
Unsupervised cluster of the complete dataset (training cohort)
Unsupervised cluster of the complete dataset (training cohort). Samples include normal lung (
We further observed that pairs of samples from the upper and lower lobes have similar global gene expression profiles, such that each pair forms its own node in the hierarchical cluster. In order to meet the assumptions of independent and identically distributed samples for developing signatures of IPF, we chose to use only one sample (the upper lobe, when available) per patient in the subsequent analyses.
Finally, we observed that explanted samples and biopsied samples largely segregate in the hierarchical clusters with the exceptions of: one pair of biopsied samples (Biopsy_159U and Biopsy_159L) and one normal sample (Normal_C) falling in the explant cluster; and a pair of explants (Explant_152U and Explant_152L) which fall in the biopsy cluster.
To further evaluate global differences in gene expression, we decomposed the high-dimensional gene expression data using principal component analysis (PCA), whereby 47% of the variance in this dataset is captured within the first two principal components for all 23 samples. Again, we found that normal and IPF samples are distinctive (Figure
Comparing Gene Expression from the Upper and Lower Lobes
To further characterize the upper/lower lobe pairs, we decomposed the gene expression data for pairs alone by PCA. This analysis captured 74% of the variance within the first three principal components. We plotted the upper/lower lobe pairs according to expression of the first three principal components (Figure
Figure 2
Comparison of samples from different lobes; comparison of samples from biopsy and explant
Comparison of samples from different lobes; comparison of samples from biopsy and explant. In panels A and B, we compare samples from the upper (
To identify genes that might be differentially expressed between the upper and lower lobes, we performed a paired LIMMA test
Comparing Gene Expression from Biopsies and Explants
To investigate the difference between biopsies and explants, we selected the data from this subset of samples (excluding lobar replicates) and decomposed the data by PCA such that 68% of the variance was captured within the first three principal components. The samples were plotted according to expression of the first three principal components (Figure
Next, we carried out the LIMMA test to identify genes that were differentially expressed between biopsy and explant. Before adjusting p-values, we plotted the results on a frequency histogram. We noted that the frequency of nominally significant p-values (< 0.05) was greater than expected by chance alone (Figure
Additional file 7
Differentially Expressed Genes, IPF Biopsies versus IPF Explants (Table S4). Between IPF biopsies and IPF explants, 13 probesets, corresponding to11 unique genes, are differentially expressed at a FDR threshold of 10%. A positive t-statistic indicates up-regulation in the explants relative to the biopsies.
Click here for file
Approach to Developing Gene Expression Signatures
A schematic diagram illustrates the process by which we develop genomic signatures using BPR models (Figure
Figure 3
Schematic diagram of the workflow
Schematic diagram of the workflow.
Because there is no prior knowledge on which to base the number of genes included in the model, we propose an iterative data-driven approach to model-fitting. We propose using the "sum of deviances" between observed and predicted phenotypes, coupled with the "misclassification rate" under a leave-one-out process, to determine the optimal size of our BPR model (i.e., the number of genes to include in the regression equation). Once the number of genes is selected, the model is summarized by the gene annotation and the average of the posterior distribution of the linear predictor under the Bayesian model. The gene signature is visualized by a heatmap that shows normalized expression values of the selected genes (rows) over the set of samples (columns).
Finally, a second set of samples is used to test the performance of the tuned model. This represents an independent validation. Because the validation dataset is derived on a different microarray platform, expression values need to be mapped and normalized in a merged dataset to account for differences in batch and the information content of each array. Then, each sample in the validation dataset is applied to the Bayesian regression model in order to generate a predictive probability (from 0.0 to 1.0) as a relative score indicating the likelihood of one phenotype over the other. Given information regarding the true phenotype of each validation sample, it is possible to construct a receiver-operating characteristic (ROC) curve for the predictive value of the gene signature.
Binary Classification for Signature Development
We chose to develop three separate models for the classification of IPF; we planned to test each model for diagnostic accuracy (i.e., functional validity) in an independent dataset. We developed the first model from all IPF samples (excluding lobar replicates) versus normal controls. This training dataset is summarized in an unsupervised hierarchical cluster (Figure
Figure 4
The training sets
The training sets. All IPF (
Since we identified differential gene expression between IPF biopsies and IPF explants, we chose to separately develop diagnostic signatures from each class, as compared to normal controls. For the IPF biopsy samples, the training dataset is summarized in an unsupervised hierarchical cluster (Figure
The three training datasets are each decomposed by PCA and the samples are plotted with regard to the first two principal components (Figures
Model Parameterization for Signature Development
For all signatures, the top two factors from singular value decomposition were used to fit independent terms to the BPR models. The "misclassification rate" and "sum of deviance" were used to determine the number of genes in each model, as described in Additional file
BPR was performed on each training dataset. Each model was visualized with a heatmap (Figure
Figure 5
Gene signatures
Gene signatures. (A) A heatmap displays the normalized expression values of 151 genes that comprise the
Additional file 8
Complete Gene List for the
Click here for file
Additional file 9
Complete Gene List for the
Click here for file
Additional file 10
Complete Gene List for the
Click here for file
Independent Validation of Gene Signatures
We used the GSE10667 dataset to test each gene signature. By using the same dataset to validate all three signatures, we were able to make a direct comparison between the models.
First we mapped the features of the Agilent microarray GSE10667 dataset to the corresponding features in our Affymetrix training datasets. We found that 148 features of the GSE10667 dataset mapped to features of the "All IPF" model (out of a possible 151 features, 98.0%); 151 features were mapped to the "IPF Biopsy" model (out of 153 possible features, 98.7%); and 69 features were mapped to the "IPF Explant" model (out of 70 possible features, 98.6%). After features were mapped, we merged the training and validation datasets. Gene expression was normalized across the merged datasets.
Then, each model was used in turn to predict the phenotype of each sample in the validation cohort (Figure
Figure 6
Validation tests
Validation tests. Each sample of the GSE10667 cohort is assigned a probability of IPF. Cutoffs were determined by calculating the Youden index. The true phenotype of each sample is indicated in color (15 normals [
ROC curves are drawn on a single graph to facilitate comparison (Figure
Figure 7
ROC curves
ROC curves. All IPF (
Table 2
Operating Characteristics of the Gene Signatures
Under the
All IPF
IPF Biopsy
IPF Explant
< 0.0001
This study shows that IPF gene signatures can be derived from whole lung tissue, given appropriate biospecimen selection and acquisition. In fact, this study serves as a proof-of-principle: mathematical models such as BPR (that handle high-dimensional data) can be used to develop multi-gene biomarkers for non-neoplastic lung disease, starting from gene expression profiles.
We profiled gene expression from whole lung in 11 patients with IPF and 6 normal controls. Samples of IPF were obtained during diagnostic surgical lung biopsies or during lung transplantation procedures. Whenever possible, we obtained samples from two different lobes of the lung. During the initial data processing phase of our analysis, we made several interesting discoveries. We found that gene expression is similar between different lobes of the lung (upper and lower) sampled from the same patient. We also found that gene expression differs substantially between IPF samples obtained at the time of biopsy versus explant.
Then we developed three gene expression models, designed for the diagnosis of IPF. These models were designed for functionality and portability: they were designed to predict the diagnosis of IPF across different patient populations and across different microarray platforms. Therefore, we needed to test our models on an independent cohort of samples containing both IPF and normal lung, to see if the models' predictions were accurate. This represents the first reported attempt to show validity of IPF gene expression signatures as diagnostic models.
We found that all three of our IPF gene expression signatures exhibited discriminatory power and could be used to predict a diagnosis of IPF (see Wilcoxon rank sum, Table
The fact that a homogeneous "IPF Explant" cohort is most robust highlights the inherent heterogeneity in the general IPF population (represented by "IPF Biopsy") and supports the need for better diagnostic tools.
In the past, other investigators examined gene expression from the lungs of patients with pulmonary fibrosis. Studies were designed to detect gene expression that was altered in pulmonary fibrosis
We acknowledge the limitations of our study. Our provisional models range from 63-83% accurate. The present study was performed on a small cohort and was only intended as a proof-of-principle. However, we believe that, by increasing the number of samples in our training cohort, we can refine the diagnostic model and increase the accuracy of diagnostic predictions. We also recognize the need to discriminate IPF from other subtypes of pulmonary fibrosis. Therefore, a definitive investigation must compare IPF gene expression with gene expression profiles of NSIP, HP and other subtypes of pulmonary fibrosis. Since BPR models are restricted to binary classifications, we would potentially extend the Bayesian SVD approach to multinomial outcomes, or other commonly employed methods for high-dimensional expression data (e.g., Classification and Regression Trees [CART]).
We show that BPR is a powerful tool for developing gene signatures from non-neoplastic lung tissue. We hope that this study will lead to the development of a definitive diagnostic gene signature for IPF. To do this, it will be necessary to collect a larger cohort of high-quality biospecimens. We suggest that BPR can also be used to develop a prognostic gene signature for IPF by training a model with samples of rapidly progressive IPF versus slowly progressive IPF. Furthermore, we believe that BPR can be used to model other lung disorders (such as NSIP, HP, bronchiolitis obliterans) by substituting with different phenotypes in the training cohort.
Competing interests
The authors declare that they have no competing interests.
Authors' contributions
EBM participated in the diagnosis and recruitment of the training cohort; clinical data analysis; microarray data analysis; statistics; conceptualization, planning and design of the study; and manuscript preparation, including preparation of the initial draft. WTB participated in the statistical design of the study, microarray data analysis and manuscript preparation. TAD, RDD, SSL, MWO and LDW participated in patient recruitment and development of the tissue acquisition protocol. TAS participated in histopathological review of the specimens; and participated in the development of the tissue procurement protocol. MPS participated in patient recruitment, development of the tissue procurement protocol and manuscript preparation. PWN participated in the diagnosis and recruitment of the training cohort; conceptualization, planning and design of the study design; and manuscript preparation. All authors read and approved the final manuscript.
This work was supported in part by the NIH SCCOR Grant on Host Defense and Chronic Lung Disease, 5P50HL084917-05. This work was also supported by a generous grant from the Drinkard Research Fund. Funding sources were not involved in study design, performance, analysis or manuscript preparation.
Mortality from pulmonary fibrosis increased in the United States from 1992 to 2003
American Thoracic Society/European Respiratory Society International Multidisciplinary Consensus Classification of the Idiopathic Interstitial Pneumonias. This joint statement of the American Thoracic Society (ATS), and the European Respiratory Society (ERS) was adopted by the ATS board of directors, June 2001 and by the ERS Executive Committee, June 2001
Idiopathic pulmonary fibrosis: diagnosis and treatment. International consensus statement. American Thoracic Society (ATS), and the European Respiratory Society (ERS)
Idiopathic pulmonary fibrosis
Strategies for treating idiopathic pulmonary fibrosis
Idiopathic nonspecific interstitial pneumonia: report of an American Thoracic Society project
Interstitial lung disease: clinical evaluation and keys to an accurate diagnosis
Diagnostic approach to the patient with diffuse lung disease
Evolving concepts in the early and accurate diagnosis of idiopathic pulmonary fibrosis
Idiopathic interstitial pneumonia: what is the effect of a multidisciplinary approach to diagnosis?
Multidisciplinary interobserver agreement in the diagnosis of idiopathic pulmonary fibrosis
Idiopathic interstitial pneumonia: do community and academic physicians agree on diagnosis?
Microarray analysis of early stage serous ovarian cancers shows profiles predictive of favorable outcome
Genomic strategy for targeting therapy in castration-resistant prostate cancer
Gene expression profiles of acute exacerbations of idiopathic pulmonary fibrosis
MMP1 and MMP7 as potential peripheral blood biomarkers in idiopathic pulmonary fibrosis
A comparison of normalization methods for high density oligonucleotide array data based on variance and bias
Summaries of Affymetrix GeneChip probe level data
Exploration, normalization, and summaries of high density oligonucleotide array probe level data
Predicting the clinical status of human breast cancer by using gene expression profiles
limma: Linear Models for Microarray Data
Statistical issues in cDNA microarray data analysis
Controlling the False Discovery Rate - a Practical and Powerful Approach to Multiple Testing
Up-regulation and profibrotic role of osteopontin in human idiopathic pulmonary fibrosis
Gene expression profiling of familial and sporadic interstitial pneumonia
Gene expression analysis reveals matrilysin as a key regulator of pulmonary fibrosis in mice and humans
Gene expression profiling as a window into idiopathic pulmonary fibrosis pathogenesis: can we identify the right target genes?
When it comes to genes--IPF or NSIP, familial or sporadic--they're all the same
Molecular phenotypes distinguish patients with relatively stable from progressive idiopathic pulmonary fibrosis (IPF)
Accelerated variant of idiopathic pulmonary fibrosis: clinical behavior and gene expression pattern
Gene expression profiles distinguish idiopathic pulmonary fibrosis from hypersensitivity pneumonitis
Pre-publication history
The pre-publication history for this paper can be accessed here:


text:
Menophytea capillary women 45 + 30 tablets
SKU 2066150 Menophytea capillary
this food supplement is specially formulated herbal vitamins, extracts, trace elements to maintain the normal hair and get beauty hair.
Menophytea capillary is recommended for women over age 45.
Take 1 tablet daily with a glass of water at breakfast.
Cure of 3 months required.
Option to renew the cure.
Stabilizer: dicalcium phosphate, thickening agent: microcrystalline cellulose, amaranth, sesame, green tea, nettle root, anti-caking agents: maltodextrin, crospovidone, talc, colloidal silica, zinc chelate, vitamin mixes: vitamin E, vitamin B5, vitamin B6, glazing agents: hypromellose - stearic acid - cellulose microcritslliane, emulsifier: magnesium stearate, food dyes: iron oxide black - yellow and Red - titanium dioxide.


text:
Beat Bankruptcy in a Week: The Quick and Easy Way To Save Your Home, Your Finances and Your Future for FREE {While Supplies Last}
This book provides you with a genuine opportunity to beat bankruptcy and get your life back on track.
Unfortunately, there is nothing easy about bankruptcy. The truth is that if you go bankrupt, many debts – including student loans and back taxes – will still stand. You may lose your home, your car and any other assets. And that' just the start of your problems. Your credit and reputation will be ruined for ten or even twenty years, and you may find it impossibly difficult to get buy a home, get credit, start a business or even travel overseas.
Fortunately for you, there is a solution, right here in this book. One that is proven to work, and which can help you turn around your finances in the next seven days. Just a week from now, you could be well on your way to financial prosperity.
I have not personally read this book, just wanted to share with any of you that may be facing bankruptcy and looking for a solution.
Thank you Lady Savings for the heads up!


text:
Goldie Felsenstein Makeup Artist
Emily RoppModel Female Grand Rapids, Michigan, US
Mayhem # 3104058
About MeThank you for viewing my page!!
I am an energetic and bubbly yet very well gathered individual, and about as confident as they get. I have been told on set before that in front of the camera I am "Very strong and intense, yet fluid and freeing"
Coming from a military family, I have moved 12 times, in 8 different states. This has given me a definite "uperhand" when it comes to meeting new people and developing relationships and connections quickly and easily.
Modeling is my passion; I have done many shoots with local photographers, but am still waiting for my "big break".
I am a very talented painter and a photographer myself... These artistic talents help me help you create beautiful art and truly moving photos on set.
I'm not looking for TF, TFP, or whatever you prefer to call it, but I'll make exceptions for really special and unique projects. I put my soul and passion into modeling, and value your time as I hope you would value mine.
Thank you again for showing interest in my work, and I would love to hear from you!!
God Bless :)
Have you worked with Emily Ropp? Add Credits for Emily Ropp! >>
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text:
Industry Research : Philippine Contact Center Industry to Double in 5 Years
The Contact Center Association of the Philippines (CCAP) released a report touting the dominance of the Philippine contact center industry in the global outsourced voice services market with revenue growth outpacing the global benchmark by almost twice the rate and its global market share growing to 24 percent, or almost 50 percent higher than its share five years ago.
The Philippine contact center industry is projected to sustain its growth in the next five years, from about $6.2 billion in revenues for 2010 to about $14.7 billion by 2016 - more than doubling the size of the industry, and corresponding to a compounded annual growth rate (CAGR) of 15 percent.
At the same time, the industry is expected to employ about 816,000 FTEs (full-time equivalents) by the end of 2016 from about 344,000 in 2010. Seat capacity is also projected to grow to more than 500,000 by 2016.
To further emphasize the remarkable growth of the industry, the estimated revenue for the Philippines for 2010 has exceeded the estimated revenue of India at $5.6 billion to $5.9 billion as reported by Everest.
This was attributed to the increase in the Philippines' share in the global call center outsourcing market from 15 percent in 2006 to nearly 24 percent in 2010.
The market share is also projected to increase to about 29 percent by 2016 if the industry's growth is sustained at the projected CAGR of 15 percent.
The growth of the Philippine contact center industry from 2006 to 2010 (at 15 percent CAGR) was noted to be comparably faster than the rest of the world, which is projected to grow by only 12 percent over the same period.
"We can attribute our phenomenal growth to the quality of service our world-class professionals consistently deliver," says CCAP president Benedict Hernandez.
"We can also point to the growth strategies our industry has undertaken to expand to new geographical markets and verticals as well as extend our capabilities in language support and higher value skills," he adds.
During the rapid growth of the Philippines in the last five years, other milestones were also achieved - from a diversification of support for up to 17 languages; an expansion of market reach to now include EMEA (Europe, Middle East and Asia), Latin America and Australasia; an extension of industry experience and expertise to now support a wider array of industry verticals including banking and finance, high technology, telecommunications, power/energy, airline, and government services; and an elevation of service offerings to now include financial advisory, health care management, legal help desk, B2B technical support, and sales channel management.
Driving the growth of the industry in the last decade has been the principal role of the CCAP, the leading organization representing the Philippine contact center industry.
The CCAP now has 80 member companies and accounts for about 70 percent of total revenues in the industry and for about 80 percent of the industry FTEs and seats.
Such optimistic growth projections are not without risks, however, as the industry faces increasing challenges that could constrain such growth.
Among the challenges include the following critical areas of concern:
• Ensuring the long-term sustainability of a qualified labor pool supply, particularly for front-line and management talent;
• Talent retention;
• Guaranteeing continuing government support for the industry, particularly in providing a consistent, favorable regulatory and incentive environment; and
• Cost concerns, particularly on labor inflation, infrastructure and utilities, and foreign exchange stability
"In order to ensure the Philippine contact center industry maintains unhindered growth for the next five years, CCAP has undertaken an ambitious effort to transform the industry," Hernandez says.
In the first 10 years of the industry, the CCAP has focused on proving the feasibility of the Philippines as a call center outsourcing location, growing the industry to attain economies of scale, and molding the industry to achieve resiliency in light of environmental pressures such as that of the global financial crisis of 2008.
In the next five years, the CCAP will be forging ahead with plans to revolutionize itself and the industry by adopting an industry roadmap that focuses on improved speed, efficiency and scale.
Among the priority thrusts and programs of CCAP for the next five years are in the following areas:
• Sustaining the supply of qualified personnel and elevating their skill proficiencies via the establishment of a Global Competitiveness Institute;
• Improving employee welfare and retention via the establishment of an HR (Human Resource) Council, and continuing research and intervention;
• Strengthening the industry and CCAP brand through an integrated media, PR and branding program;
• Improving the business environment for call centers via PPP program development; and
• Consolidating all these efforts via the establishment of a full-time CCAP executive team.
Through these thrusts and programs, the CCAP envisions an evolving role in the pursuit of its mission — to transform the CCAP into an organization that is faster (more efficient and cost-competitive), higher (a higher quality and higher capability workforce), and stronger (supported by industry-wide and multi-sectoral initiatives).
Posted by Veronica Silva Cusi, news correspondent
Source: http://www.philstar.com
Related Editorial
- Philippines' Rise as Call-Center Nation Lures Expats Home
- Negros Occidental Should Benefit from Growth in ICT-BPO Industry
- Outsourcing Industry Urged to Unite
- Economist Downplays BPOs as 'Savior' of Economy
- Call Me: Tech Powers Philippines Call Centre Success
- Philippine Central Bank Official Calls for Economy Less Reliant on BPO
Published: Monday, August 8, 2011


text:
65 Million years ago, a meteor the size of Mount Everest strikes the Earth and wipes out the dinosaurs. However, what if the meteor was a little smaller and allows humans and dinosaurs to evolve alongside each other.
Differences from OTL
- Dinosaurs evolve into intelligent creatures known as Homo Reptilia.
- Humans gain dominance following the Ice Age.
- Dinosaurs are enslaved by Colonial empires instead of Africans.
- The book Dinotopia is never written and doesn't give rise to the TV series and movies.


text:
Remember Me
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Premium Subscribers & members of my network may view my contact information.
Great motivator.
- Alistair Morrison (3/17/08)
Ron is an exceptionally able performer who could work with anybody to deliver to the tightest of deadlines and is one of life's true entrepreneurs.
- Mark Freman (3/17/08)
Ron is a professional and considerate individual
- George Kennedy (3/17/08)
Ron is highly experienced, knowledgeable and enthusiastic. He shows great integrity in his work.
- Clive Shepherd (3/17/08)
Ron is a leadinng member within the training community and has the vision to continue to enhance training methods and practices.
- Dylan Stokes (3/17/08)
Peer Assessment:66
Social Influence:?
ron mackrell
© 2006-16 Viable Ventures, LLC. All rights reserved.


text:
An important factor in easyJet's carbon emissions reduction and fuel efficiency will be the introduction of the new generation of Airbus short-haul aircraft. In 2013 easyJet confirmed an order for 100 new generation Airbus A320neo aircraft for delivery from 2017 to 2022 and has taken purchase rights on a further 100 aircraft. These aircraft, equipped with CFM LEAP-1A engines and wing 'Sharklets', will be 13% to 15% more fuel efficient than existing aircraft types.
easyJet has also worked with Airbus on a new cabin design for A320 family aircraft which will add a further six seats, whilst maintaining the current level of passenger comfort. The first new aircraft with this cabin design is due to be delivered by Airbus in May 2016 and the cabin layout is planned to be retrofitted to existing A320 aircraft between autumn 2016 and spring 2018. This will create the opportunity for easyJet to further increase the number of passengers on each aircraft, contributing to increased environmental efficiency.
To further reduce emissions in the longer term, significant progress in the development of a new generation of aircraft will be necessary. While there has been some progress in the short-haul market, a further step change in efficiency is necessary. easyJet will continue to press the manufacturers to deliver this and supports the establishment of international minimum standards to drive the development of new technology aircraft.
easyJet Airline Company Limited Registered in England with Registered number 3034606; subsidiary of easyJet plc Registered in England with registered number 3959649 Registered Office: Hangar 89, London Luton Airport, Luton, Bedfordshire LU2 9PF


text:
True Made Foods
Albany, NY
In an effort to get True Made Foods co-founder Kevin Powell to eat healthier, his wife Abbey did what any loving spouse did: she hid veggies in his meals. One day she used spinach, carrots, and butternut squash to create ketchup, and Kevin loved it! That became the recipe for "True Made Ketchup," the first of many True Made products after Kevin joined forces with Abe Kamarck in late 2014. Since then their philosophy has been simple: use less sugar and add more nutrition – real nutrition – by adding a significant amount of real vegetables to every bottle.


text:
The Federal Bureau of Investigation on Tuesday will brief the Senate Intelligence Committee on what it learned from an interview it conducted in 2011 with Boston Marathon bombing suspect Tamerlan Tsarnaev, and why it did not pursue him further at the time.
The briefing on Tuesday afternoon will be classified and the witnesses are not yet known, according to a source close to the proceedings.
A handful of lawmakers in the House, including Speaker John Boehne (R-Ohio) have vowed to conduct briefings and hold hearings into how the brothers operated under the radar of the FBI after the Russian government notified federal investigators that the older brother was a potential threat.
The tip from Russian authorities came after the suspect spent six months in two Russian provinces in 2010 and 2011 before returning to the U.S.


text:
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Term time: Kent Sport facilities will be open on Bank Holidays that are within term time, but may operate on reduced opening hours. Please check at reception for more information. Please see the following list of Bank Holidays which fall within term time:
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With so many exciting events and activities at Kent Sport, occasionally we have to close for an event or for staff training, team-building and maintenance. These will be advertised at the facilities and on our social media sites, please Like us on Facebook and follow us on Twitter UniKentSports.


text:
U.S. Department of Transportation
Federal Highway Administration
1200 New Jersey Avenue, SE
Washington, DC 20590
Federal Highway Administration Research and Technology
Coordinating, Developing, and Delivering Highway Transportation Innovations
|This report is an archived publication and may contain dated technical, contact, and link information
Publication Number: FHWA-HRT-04-133
Date: December 2005
Enhanced Night Visibility, Volume II: Overview of Phase I and Development of Phase II
PDF Version (687 KB)
PDF files can be viewed with the Acrobat® Reader®
Figure 9. Photo. Smart Road testing facility.
The Virginia Smart Road (figure 9) is a unique, state-of-the-art, full-scale research facility for pavement research and evaluation of Intelligent Transportation Systems (ITS) concepts, technologies, and products. It is the first facility of its kind to be built from the ground up with its research infrastructure incorporated into a section of public roadway. Originating in Blacksburg, VA, the Smart Road presently consists of 3.2 km (2 mi) of two lanes of roadway, which are closed to public traffic and are designated a controlled test facility. When completed, the Smart Road will be a 9.6 km (6 mi) long, four-lane section of the U.S. Interstate system, connecting Blacksburg, VA with U.S. I–81. This connection will serve an important role in the I-81 and I–73 transportation corridor. After completion, provisions will be made to route traffic around controlled test zones on the Smart Road to allow for ongoing testing.
Construction of the Smart Road project was made possible through a cooperative effort of several Federal and State organizations, including VTTI, VDOT, VTRC, FHWA, and Virginia Tech.
The research-supported infrastructure of the Smart Road makes it an ideal location for safety and human factors evaluation. Following is a list of some of the unique research capabilities of the facilities:


text: In-Game Examine Window Breastplate of Seething Hatred other resources EQ2U · LootDB · EQ2LL · ZAM · Census xml Breastplate of Seething Hatred FABLED LORE NO-TRADE +55 str +40 agi +40 int +50 sta +340 health +340 power +1,512 vs elemental +1,596 vs arcane +7 Slashing 7% Crit Chance10% Potency +10 Base Taunt AmountSeething Hatred Plate Armor (Chest) Mitigation 706 Level 80 (Tier 9) Berserker, Guardian, Paladin, Shadowknight Effects: When Equipped: On any successful attack this spell has a chance to cast Seething Hatred on target of attack. Lasts for 15.0 seconds. This effect will trigger an average of 2.0 timer per minute. Increases Shield Effectiveness of caster by 15% Increases Casting Speed of Caster by 20 Inflicts 705 - 862 disease damage on target Reduces all damage done to caster by 5% Increases Threat to target by 2,394 - 2,926 Must be in front of Obtain: Dropped by Avatar of Disease in Antonica Avatar of Hate in Nektulos Forest The author wishes to credit LootDB. What does this information mean? Retrieved from "http://eq2.wikia.com/wiki/Breastplate_of_Seething_Hatred?oldid=443331" Ad blocker interference detected! Wikia is a free-to-use site that makes money from advertising. We have a modified experience for viewers using ad blockers Wikia is not accessible if you've made further modifications. Remove the custom ad blocker rule(s) and the page will load as expected. Categories: Equipment Plate Armor (Equipment Type) Chest (Inventory Slot) Equipment pages with existing iname images Fabled Equipment Elemental Resistance (Equipment) Arcane Resistance (Equipment) Slashing (Equipment) Crit Chance (Equipment) Potency (Equipment) Tier 9 Equipment Warrior Equipment Berserker Equipment Guardian Equipment Crusader Equipment Paladin Equipment Shadowknight Equipment LootDB Credits Articles missing itemlink Add category Cancel Save


text:
From Donny & DebbieDear Friends,
Donny Osmond Home is a celebration of life and love. Debbie and I consider Home and Family to be the most important aspects of our lives. Because we are so committed to these values, we are excited to share Donny Osmond Home with you and your family.
Our mission is to encourage families to "Make Home and Family #1." This is a dream we share with our manufacturing partners and strive to realize through our website, its contributors, and our community of friends and fans throughout the world.
We are dedicated to creating innovative products with premier quality and comfort at the forefront of design. Within the collection, you will discover uplifting brand messages that inspire families to spend more time together, creating celebrations, cultivating cherished memories, and simply having fun.
Our Home collection offers a casual, comfortable point of view, encouraging family togetherness with its warm, welcoming style. We understand 21st Century living is beyond busy, which is why we are absolutely committed to designing contemporary products that make it easy to make time for what matters most.
We look forward to helping you transform your Home into a place where Family is #1.
Let's make time, together!
Donny and Debbie Osmond
The Brand
After 50 years of entertaining, Donny Osmond, role model for Home and Family, joins his wife Debbie in launching Donny Osmond Home by Donny and Debbie Osmond. The brand's richness and heritage celebrates life and love with the tag line, "Making Home and Family #1." Brand Management is provided by Clique Here, LLC with offices in Decatur, Georgia and Oakland, California. The brand personifies the same values and qualities that have made Donny an aspirational icon throughout the decades – it represents trust, excellence, integrity and family focus. Donny Osmond Home turns familiarity and fond memories into products that enhance harmony at home and encourage family togetherness.Contact Us
Current Licensees
Donny Osmond Home works with best of class manufacturers who understand precision in executing all aspects of design, craftsmanship, and quality materials. Product categories include Bedroom, Living Room, Dining Room Furniture and Upholstery, Home Décor, Wall Art, Rugs, Lighting, Accent Furniture, Outdoor Furniture, and Preserved Botanicals.Wholesale
Manufacturing Partner
|Bedroom, Living Room, Dining & Upholstery
|Sagebrook Home
|Home Decor, Accent Furniture
|KAS Rugs
|Area Rugs, Indoor/Outdoor Rugs
|Capital Lighting Fixture
|Hard Wired Lighting Fixtures
|Art Trends
|Wall Art
|Preserved Botanicals
|Outdoor Furniture
|Achim Imports
|Wall Tiles


text: You have now completely lost me? Calling it "junk science" is pretty strong, and I think inappropriate. It is well documented how earthworms affect soils. In most cases it is a positive affect, however in some cases it apparently can have a negative affect. I am confused at why you cannot see how exotic introduction of earthworms into an ecosystem can have a dramatic effect on the ecological composition and structure of that system. If you think the information and findings are incorrect, then you need to read the publications and formulate a logical case against them by either presenting a discussion of research that contradicts their findings and/or do your own research.


text:
Researching Ethically With Human Subjects in Cyberspace
Siang, Sanyin
Bibliographic Citation
Professional Ethics Report 1999 Fall; 12(4): 1, 7-8
MetadataShow full item record
Related items
Showing items related by title, author, creator and subject.
Ethical and Legal Aspects of Human Subjects Research on the Internet. Report of a Workshop June 10-11, 1999, Washington, DC Frankel, Mark S.; Siang, Sanyin (American Association for the Advancement of Science [AAAS], 1999-11)
Americans concerned about ethics, morality of scientific research, survey shows Siang, Sanyin (2001-12-19)
Scientific Societies and Research Integrity: What Are They Doing and How Well Are They Doing It? Iverson, Margot; Frankel, Mark S.; Siang, Sanyin (2003-04)


text:
2016 has been a year of anniversaries for Irish modernism studies, dominated by the Easter Rising commemorations. Though it is perhaps not quite as prominent, among these there have also been a sequence of celebrations of #Flann50: the fiftieth anniversary of the death of Brian O'Nolan, an Irish modernist who is mainly referred to by his pseudonym, Flann O'Brien. This might be the last article to mark that anniversary which comes out this year, and I want to use it to remember not Flann O'Brien but Myles na gCopaleen. This is because, for many readers, it was Myles who died on April Fool's Day in 1966 (now celebrated as 'Myles Day' in Dublin). Remember that, after At Swim-Two-Birds in 1939, Flann O'Brien did not produce another novel until 1961. In contrast, Myles and his satirical Cruiskeen Lawn column appeared several times a week in the Irish Times for a quarter of a century (not to mention his popular 1941 Irish-language novel, An Béal Bocht, or the plays he wrote under that name).
So it seems just as appropriate to recollect Myles as it is to celebrate Flann. Cruiskeen Lawn runs to somewhere between two and four million words. Modern readers are likely to encounter it in one of several slimmed-downed compilations produced after his death, but there are two occasions when O'Nolan chose to reprint anthologies of Cruiskeen Lawn himself. The first was in 1943 when he published this bilingual anthology, which, as Steven Curran has argued in Éire-Ireland (and as its headline suggests) may well be an attempt to sharpen the focus on the satirical persona of Myles by cutting back on the supporting cast:
Front cover of the 1943 anthology of Cruiskeen Lawn
The second occasion was in 1959-1960, when O'Nolan republished about sixty columns in four numbers of a short-lived periodical which was called Nonplus, edited by the novelist Patricia Murphy (née Avis).
Front cover of Nonplus 2 (Winter 1960)
The older O'Nolan also preserves a particular flavour of Cruiskeen Lawn by favouring some types of column over others. Whilst the Brother appears here and there and Keats and Chapman feature twice, just as in 1943, the republished columns are predominantly complex and multilingual satirical sallies into heavyweight topics: aesthetics, language, literature, politics and the national culture. (I should note that it's been suggested that many of the more 'literary' columns were written by co-author Niall Montgomery.)
Some of this reprinted Nonplus material had already been published not once, but twice. This creates unusual effects. One such doubly reprinted column appeared first in 1946 (and this is the version that O'Nolan republishes in Nonplus, but more on that later) and again in 1958. It's a set of preoccupations about posterity and maturity combined with strange recollections on time that turns into a plagiarising pastiche of the theories of W. B. Yeats.
Sufficiently interested? Okay, I'll try to summarise.
On 7 August 1946, we find Myles 'in my office in the Scotch house' worrying about 'myself, my future, my writings' and becoming irritated by the fact that:
I am very ancient yet I never seem to grow old enough. Why, bless me – I occasionally come across something that is new to me! Honest! Certain small grains of knowledge have eluded me, sundry minute subfacts are yet to be gathered into the vast intellect which reposes, were it but known, behind the most beautiful face in the world!
Suitably dissatisfied that he does not feel 'quite mature', Myles sends for the proprietor of the pub, Foley, and asks to be put in a whiskey barrel to mature more quickly. Foley refuses, having not 'a square inch of space in the cellars'. Myles, thinking of 'some other way of maturing more quickly', reflects that 'maturing is not solely a matter of time, but the time factor is important and it happens I know him well'.
He recalls the role of the 'time factor' during a strike on the Dublin docks when 'there was a lot of extra time being imported for building contracts'. Of course, with no-one to transport all that time, 'do you know what happened? It went bad'. Dealing with this 'bad time' caused a further dispute between the 'time factor' and the 'mairrchints'. The 'time factor' successfully claimed its right to payment by invoking the 'war clause'. But the bad time lingered on uncollected as, after all, 'there was no provision in the rates for wet time'. Of course, in all of this the time factor did 'himself a lot of hairrm with the mairrchints'.
After some reflections on humanity's conflicts, happiness and civilisation, Myles then locates 'in an old diary of my own' a fragment about how 'all happiness depends on the energy to assume the mask of some other life' and how 'Active virtue, as distinguished from the passive acceptance of a code, is therefore theatrical'. It's all obviously lifted from Yeats and Myles spends the next four hundred words extensively plagiarising Yeatsian dialectics, invoking 'the ridiculous Camus' and declaring that he, Myles, alone 'has the honour to be a saint and proposes to climb without wandering to the antithetical self of the world'.
On 14 April 1958 Cruiskeen Lawn returns to the same material, freshly retitled 'Chronitis'. Myles reports to his readers that 'the other day I went – á la recherche du temps perdu, perhaps – into my old office, the Scotch House: the place once wittily I had called Grandeur de Foley'. This is a clear signpost that material is about to be pillaged from an older column. However, ten years on, Myles's plagiarised worrying is very subtly different:
Yes, worrying. About myself, my writings, my poetry, my future. You see, I have the impression of having been here a long time, yet do not seem to be growing old enough. Extraordinary complaint if you like but I have no corns or ulcers and I am still encountering things which are quite new to me. Surely this is embarrassing immaturity and damn the thing else? Am I inexperienced? Callow? Or is this … innocence?
Whereas the younger Myles says 'I am very ancient' in 1946, twelve years later the older Myles has, more vaguely, 'the impression of having been here a long time'. Rather than being 'very ancient' but somehow not 'growing old enough', he does not feel old at all and is instead beset by an 'embarrassing immaturity'. O'Nolan has aged twelve years, but Myles has regressed to a state of childlike innocence. Cruiskeen time, it seems, runs backwards.
Myles in 1958 paves the way for some relativistic distortions when he starts discussing 'the experience of duration' and the 'expositions and expostulations of men such as Minkowski, Einstein, Eddington'. Then, instead of re-using its material he recalls, in new words, experiencing the events of the 1946 column: 'I had all this disquiet many space-years ago on another visit to the Scotch House'. That is, the events of the earlier account which he plagiarised at the beginning of this new column. This new and old account also includes the story about asking Foley to 'put me into bond', and eventually the same account of the dispute over 'bad time' starts up again. To describe both columns as a sequence:
- Myles visits the Scotch House in 1946 where he reflects on maturity and time
- In 1958 he describes a new visit to the Scotch House 'à la recherche du temps perdu', but the textual account of the new visit is plagiarised from the previous one
- The actual 1946 visit is then described again in the 1958 narrative as a recollection
- However, in the course of this recollection the column metamorphoses into a verbatim repetition of the 1946 version as if the first column had simply started up again
- Now return to the beginning: Myles visits the Scotch House in 1946 where he…
The later column ends before we are treated to the same Yeats material but the wording running up to it is identical to the earlier column, apart from the added joke: 'Any reader with time on his hands might send me some. I'm serious!'. It's as if there is simply no space (or perhaps time) for the 1946 column to be repeated in full. To put it another way: the first visit is the textual basis for the second visit, but the first visit returns a second time when it is recollected separately in the text, only for that recollection to turn back into the first visit.
So despite Myles's promise in 1946 that 'there won't be any loop-holes', the doubling of the two visits to the Scotch House and the way that the later column bleeds back into the earlier version does indeed produce a loop in time. Thanks to the shunting back-and-forth between the event itself and its written depiction at the start of the 1958 column, we can imagine both visits as repeatedly layered on top of each other: taking turns as the event described and the material describing the event.
Irish Times, 7 August 1946 and Irish Times, 14 April 1958
This loop is discernible only when the first and second versions of the column are read alongside each other, and it appears that O'Nolan used this reprinting opportunity to maximise the possibility of this happening. For as mentioned earlier parenthetically, in Nonplus the column which is republished is an exact replica of the 1946 version and not the 1958 version. O'Nolan reprints the first version at a point when the second version is relatively close to hand – having been published in the Irish Times only two years ago – thus completing the 'sequence' and closing the loop which he opened fourteen years previously.
It's sometimes suggested that O'Nolan re-uses old Mylesian material simply out of convenience or a lack of creativity. But his doing so in order to construct an infinite sequence of visits to the Scotch House (no doubt, he made quite a few) demonstrates that he is up to something much more ingenious than that. By reprinting the first version, and not the 'plagiarised' second, in Patricia Avis's periodical, he is revelling in this practice rather than making any attempt to conceal it.
Nonplus 2, p. 54
Did I mention that the Scotch House pub itself is actually advertised in the same issue of Nonplus on the page after the Cruiskeen Lawn extracts? Just in case, presumably, any reader wanted to try out the whisky or the loophole for herself. Given all this confusion of space and time, it seems fitting to conclude my #Flann50 commemoration with Myles's own warning about relativity in the 1958 version:
One reads that Newton distinguished two kinds of interval-distinguishing events – distance in space and lapse in time. But what is it that lapses? The time-space men confute Newton and say there is in fact one interval. Do you know, it would put years on a man.
About the Author
Tobias Harris is an M.Phil student at Birkbeck College, University of London, completing a thesis about Brian O'Nolan and his international influences. He has published an essay in the Parish Review and a review in the James Joyce Broadsheet. Tobias attends both of the Joyce reading groups at Senate House, London.


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wikiHow to Increase Your Laptop Battery's Life
Follow the few steps to increase the laptop battery's life:
1Lower the brightness on your screen. The screen of your laptop takes up significant amount of power and you do not require its maximum brightness. You should have to check your system and decrease the screen brightness it to a comfortable point.
2Stop your wireless signal when you are not using it. Turning off your laptop connections can save max. 20 minutes of your laptop's battery time because WiFi can use a considerable quantity of power. By right clicking you can stop your WiFi signal when you are not using.
3Manage the correct power scheme in XP. Windows XP contain a number of predetermined power plans, which control settings like how rapidly your laptop turns off and when your screen saver boots in. You can change your laptop power scheme by choosing Control Panel Power Options. For max. Battery life from the "Power scheme" chooses the option "Max. Battery" and decline the list. There are good choices for you just like "Low Power Mode" and Portable /Laptop. They don't conserve as much power as Max Battery. After selecting a power scheme you click Ok button to finish the process.
Community Q&A
How do I change the screen brightness in Windows 10?Depending on what type of computer you have (HP, Dell, Acer, etc.), there are different ways. First, try holding FN (under the left shift button) and pressing the right arrow key to make the brightness higher. To make it lower, hold FN and press the left arrow key. If that doesn't work, press F12 to make it higher and F11 to make it lower.
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- Lower the backlighting on your screen.
- Use the battery in power save when doing less CPU usage work.
- Stop your wireless signal when you are not using.
- Manage the correct power scheme in XP.
- The screen of your Laptop takes up significant amount of power and you do not require its maximum brightness.
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Categories: Laptop Batteries
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Privacy policy
Updated December 2016
The Website is operated by HHGL Limited trading as Homebase ("Homebase/we/our/us"), a company incorporated in England (Company Number 533033) with registered address at Witan Gate House, 500-600 Witan Gate, Central Milton Keynes, MK9 1BA.
As user of the website (referred to as "you/your") you acknowledge that any use of this website (including any transactions you make) is subject to this Privacy Policy together with our Terms and Conditions.
The purpose of this statement is to set out the purposes for which, and the manner in which, we may collect and use personal information that we may obtain about you.
Homebase does not knowingly collect data from any unsupervised person under the age of 18. If you are under the age of 18, you must not use the Homebase website or submit any personal data to us unless you have the consent of, and are supervised by, a parent or guardian.
Use your personal information
1. When you register and/or use this site:
- Some of our services will require further details, for example, which will require further information to set up and maintain those services.
- In addition we may gather other information about your use of the website, including by the use of cookies (see our cookies policy page).
2. We may use information you give us or we obtain...
- to register you with our Website and to manage any account you hold with us
- to give to companies and organisations whose products we provide to you e.g. product, home and financial
- to fulfil our agreement with you and to process your order and obtain payment
- to analyse and profile your shopping preferences (e.g. market, customer and product analysis) to enable us (i) to provide you with a personalised browsing experience when using the website and (ii) to review, develop and improve the products and services which we offer and to enable us to provide you and other customers with relevant information through our marketing programme
- to administer any prize draws or competitions you may enter.
- to facilitate your transaction and browsing experience with us.
- we may use your information to make decisions about you using computerised technology, for example automatically selecting products and/or services which we think will interest you from the information we have
- We may use information that you provide or that is obtained by us:
- where you have agreed that we may do so, we may keep you informed of products and services (including products and services of other companies and organisations and including special offers, discounts, offers, competitions, warranties, insurance and so on) which we consider may be of interest to you by any of the following methods:
- Telephone (including automated calls)
- SMS text messages and other electronic messages such as picture messaging
- Post
- where you have agreed that we may do so, we may keep you informed of products and services (including products and services of other companies and organisations and including special offers, discounts, offers, competitions, warranties, insurance and so on) which we consider may be of interest to you by any of the following methods:
1. If you do not wish to receive information of products and services which may be of interest to you from us, you can select the opt-out option when you submit your details or you can unsubscribe at any time by sending us an email as described in the section "Want to be removed from the Homebase email newsletter list?" below
2. We may supplement the information that you provide to us with information that we receive from third parties. In particular we will carry out searches with credit reference agencies
3. We may engage third party payment providers to administer and process your payment card details in order to complete any purchase that you make through the website.
4. We may store and process your information on our own information technology systems or on systems owned by third parties that may store and process your information on our behalf.
Crime prevention
In order to protect our customers and us from fraud and theft, we may pass on information that we obtain from making identity checks and other information in our customer records, including how you conduct your account, to other Group companies, other retailers and to financial and other organisations involved in fraud prevention and detection, to use in the same way.
Without limitation to the foregoing we may disclose any information and data relating to you to the police or any regulatory or government authority including but not limited to law enforcement agencies in response to a request in connection with the investigation of any suspected illegal activities.
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Calls may be recorded to verify content and may be used together with other customer records for regulatory compliance, quality control and staff training, preventing or detecting criminal activity and for complaint resolution.
Disclosure of your information
We may give information about you to the following companies and organisations, who may use it for the same purposes as set out above:
- agents who (on our behalf) profile your data so that we may tailor the goods/services we offer to your specific needs
- to other organisations for the administration of prize draws or competitions
- to anyone to whom we transfer or may transfer our rights and duties under our agreement with you
- if we have a duty to do so or if the law allows us to do so
We refer in paragraph 4 of Use of Your Personal Information above to the fact that we may carry out credit reference agency searches to obtain information about you. These agencies record those searches. In addition to the purposes listed above, we may also share information about you and the conduct of your account with credit reference agencies, other lenders and relevant third parties including our legal advisors and debt recovery agencies.
In carrying out the activities specified in this policy, we may transfer data to reputable companies outside the European Economic Area. Whilst we take reasonable steps to ensure that your information will be afforded the same level of protection as that required of us under applicable UK data protection legislation you should be aware that countries outside the European Economic Area may not offer the same level of protection of personal data.
This site uses cookies which are text files which contain small amounts of information that a website can send to, and store on, your computer or device through your browser. Cookies may be used by us to provide you with, for example, customised information from our website to make our website more user-friendly. This may include, for example, remembering your postcode for you so you don't have to re-enter it every time you check the stock levels for an item you are interested in.
In addition, cookies allow us to understand who has seen which pages and advertisements, to determine how frequently particular pages are visited and to determine the most popular areas of our website.
We are required to provide you with clear and comprehensive information about the cookies which we use on the site and to obtain your consent to the use of the cookies. In order to comply with these requirements we have prepared a cookies policy setting out information about cookies, detailing the cookies we use and providing information on how to manage cookies on your computer.
By using the Homebase website, mobile website and Apps, you are agreeing to our Privacy and cookie policies and consent to the use of cookies and similar technologies by us and our carefully selected third party partners as described in these policies. If you do not agree to such use, please see the 'Managing your cookies' section for details on how to adjust your settings.
For full details about our cookie policy, please see our cookie policy page.
We will treat all of your information in strict confidence and we will endeavour to take all reasonable steps to protect your personal information. However, we cannot guarantee the security of any data you disclose online. You accept the inherent security risks of providing information and dealing online over the Internet and will not hold us responsible for any breach of security unless this is due to our negligence or wilful default.
For further information about the steps we take to protect your information and make online shopping as secure as possible, please see information on secure online shopping.
Product reviews
Around 2 weeks after receiving your product, we may send you an email inviting you to review and rate the product that you purchased. In addition, sometimes we may also ask you if you would like to answer questions related to your product submitted by other customers.
Please be aware that:
- once submitted, it usually takes 72 hours for your review, question or answer to appear on the website provided it adheres to our publishing guidelines.
- your review can be submitted anonymously or if you prefer you can leave a ratings only review.
- it is not possible for you to edit/remove your review after submission.
If you require any further information on this website or wish to have your review removed, you can contact customer services.
We may in our absolute discretion accept or reject any product review which may be submitted to us and may edit any such review for both length and/or content as we see fit. All reviews are submitted on the basis that Homebase may use the review in any format and for any purpose as it sees fit and for any marketing or promotional purposes.
You have the right to see the personal data (as defined in the Data Protection Act) that we keep about you, upon receipt of a written request and payment of a fee the contact address below: Homebase Website Customer Services, Acton Gate. Stafford, ST18 9AR
If you are concerned that any of the information we hold on you is incorrect or you have a general enquiry in connection with our Privacy policy, please contact us. You can also write to the Data Protection Compliance Officer at Homebase, Witan Gate House, 500-600 Witan Gate, Central Milton Keynes, MK9 1BA.
Please be aware that our website may link to other websites which may be accessed through our site. We are not responsible for the data policies or procedures or the content of these linked websites.
Want to be removed from the Homebase email newsletter list?
If you want to be removed from our mailing list (other than Homebase Homemovers), click here to use our unsubscribe form and put in the email address that you wish to be removed. Please note that it may take up to 28 days to action your request. In addition, each email we send you will contain details of how you can unsubscribe.
If you wish to unsubscribe from Homebase Homemovers direct mailings (postal) please call our customer service team on 0345 077 8888 (UK). Please note that it may take up to 28 days to action your request.
In addition, each electronic mailing we send you will contain details of how you can unsubscribe.
Changes to policy
We may amend and update this policy from time to time.
Any changes in the future will be posted on this page.
The date of the latest update to this privacy policy is set out at the top of this policy.


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NFL rookies will have their convention this summer after all.
The NFL Players Association said Tuesday it would host the rookies for a conference on June 28-29 in Washington, D.C. (Via SI.com)
Called "The Business of Football: Rookie Edition," the event will be a substitute for the annual rookie symposium that the NFL cancelled earlier this month.
"It was important for us to do this because it's a critical time in the lives of players who are about to enter the league," NFLPA spokesman George Atallah said.
"Lockout issues aside, it's important that players are prepared for this next phase in their lives and careers."
All drafted players will be eligible, and the NFLPA will cover the costs.
Among the topics players will learn about will be financial planning, security, interactions with the news media and professional responsibilities.
The league cancelled its normal rookie symposium because of the lockout. NFL rules prohibit contact between players and teams during the work stoppage.
Nate Davis is a reporter, blogger and editor who's been at USA TODAY since 2000. He has covered the NFL since 2005. No, he did not play quarterback for Ball State. Davis' succession of our esteemed colleague Sean Leahy at The Huddle is considered a Brady-for-Bledsoe swap by most "insiders."More about Nate


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PELICAN BAY is one of the most desirable beach front neighborhoods in Naples. Pebble Creek is directly across the from the North station providing easy shuttle access to the beach where you will enjoy two private casual restaurants, chair umbrella set up service, and miraculous sunset views. This residence has three spacious bedrooms, 3 baths, eat in kitchen, and spacious lanai with a Jenn Aire electric grill and a very pleasant, private landscape. Brand new TV-55 curved Samsung HDTV. There is underground parking with a private garage ample parking for a second car. Pelican Bay is very close to Mercato,...
the newer upscale shopping restaurant entertainment area in North Naples. The community offers over 3 miles of pristine beach, tennis and an extensive fitness facility. There are two movie theaters, dozens of restaurants and a state park beach with grills and picnic tables nearby. The philharmonic Artis Naples and our art museum borders Pelican Bay. This is a one of a kind neighborhood for Naples. Don't miss out spending a few months in this spacious and very comfortable property. This property is available for a 3 month period or up to a one year.
|Rental Fee
|Property Type
|Single-Family Home
|Not available
|1,857 sq. ft.
|Pets Allowed
|Please inquire
|Please inquire
|Direct Link
|Last Updated
1 Year Lease
Single-family home located at Pebble Creek Cir in Naples, FL 34108 has 3 beds, 3 baths, 1,857 square feet and available to rent for $4,000. Pebble Creek Cir was listed on RentalSource 180+ days ago by Steven Kelley. Pebble Creek Cir is in zip code 34108 which is located in Naples, FL. The rental price of $4,000 is 18% lower than the average rental price of $4,912 for homes for rent in 34108 and 1% lower than the average rental price of $4,063 for homes for rent in Naples, FL.Report listing | Visit website
Beware of rental scams! Situations involving wire transfers or a landlord who can't meet you in person can be red flags.


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