text:
Monday, December 22, 2014
Silver Lining Picks Up Where Calxeda Left Off
One of the biggest losses in Austin's high tech industry in the last few years was the loss of low power server processor developer Calxeda, which shut down almost exactly a year ago. However, all was not lost--Silver Lining, which is a subsidiary of AtGames Cloud Holdings, has apparently picked up the assets of Calxeda and has continued the technology development done at Calxeda. According to Silver Lining, the company is being advised by Calxeda founder and CEO Barry Evans, and currently has partnerships with Foxcon server group and ARM.


text:
Howard Elliott Strike a Pose Silver Body Sculpture
$ 230.00
Strike a pose! This figure is fashioned from ceramic into an elegant posing female shape. It is then finished in an electroplated nickel so metallic, it has a mirrored effect. Alone or in multiples this statue will look great in any room. Console tables, book shelves, pedestals or any other place that an accent is needed, are the perfect places for this piece.
- Strike A Pose Collection
- Electroplated Nickel Finish Posing Figure Sculpture
- Ship Via FedEx: Yes
- Materials: Ceramic
- Dimensions: 9.5" w x 5" d x 21.5" h
- Box Dimensions: 24" w x 10" d x 8" h
- Weight: 6 pounds

subset: commoncrawl


text:
This recipe should really be called, "Liver and blood support salad." Here's why…More
Cabbage and Apple Salad with Honey Ginger Dressing
Did you know that cabbage is rich in choline, beta carotene, folate, fiber, and vitamins C, K, and B6? It's time to incorporate more cabbage into your Spring diet!More
Fall Pear, Lettuce and Shitake Bacon Salad
Have you ever tried Shitake mushroom bacon? It's crunchy, salty and totally delish!More
Grilled Nectarines and Baby Arugula Salad
Don't put your grill away yet! This Grilled Nectarine salad is the perfect ending to a delicious summer.More
Stone Fruit Summer Salsa
Do you want to try a fun summer salsa? Use stone fruit!More
Bibb Lettuce with Blueberries and Honey Lemon Dressing
It's salad season! Combine your favorite lettuce and berries, and drizzle with Honey Lemon Dressing. Oh my… mouthwatering seasonal goodness!More
Flower Power Spring Salad
Do you want to taste spring? Try this floral salad with Lemon Honey Dressing. It's as delicious as it is beautiful!More
Baby Spring Greens with Horseradish and Honey Dressing
Horseradish is one of those amazing foods that helps clear congestion. Try it on your next salad to clear your body and your head.More
Dandelion Fennel & Apple Salad with Toasted Milk Thistle Seeds
It's time to love your liver with this tasty, cleansing and liver-supportive salad.More
Marinated Carrot and Daikon Radish Salad
Looking for an easy breezy winter salad? Try this one. It's delish!More
Yasou Greek Salad!
I love the international flavors of various foods. Like this Yasou Greek Salad. Yasou means… to your health!More
Watermelon and Cherry Tomato Salad with Summer Herbs
It's summertime! Enjoy this cool, refreshing watermelon and cherry tomato salad. It's a mouthful of sweet and savory chill time.More
Marinated Dandelion and Radish Salad with Apple Cider Vinaigrette
Bitter and spicy is good for you! This Marinated Dandelion and Radish Salad is sure to leave you feeling fresh and invigorated.More
Cobb Salad with Honey Dressing and Kale Flowers
Want a mouthful of seasonal goodness? Enjoy this delicious Cobb Salad recipe using ingredients from the local farm!More
Sweet Summer Slaw with Lemon Honey Dressing
Crunchy and sweet, this Summer Slaw is a delicious way to eat your veggies.More
Parsley, Garlic and Walnut Dressing
As the weather gets warmer, it's time to lighten up and move from stews to salads. Try this Parsley, Garlic and Walnut Dressing and let me know what you think!More
Quick Quinoa and Grass-Fed Lamb Salad
As the weather gets warmer, it's time to lighten up and move from stews to salads.More
Dandelion and Cabbage Salad with Horseradish Dressing
Clear out liver congestion. Try this Spicy Dandelion & Cabbage Salad with Horseradish Dressing and let's get moving!More
Cucumber, Tomato & Onion Salad with Dulse
Try this refreshing Cucumber, Tomato and Onion Salad with a pinch of Dulse. Yum!More
Beluga Lentil Salad with Peppadew Peppers
Have you ever tasted Peppedew peppers? Sweet and mildly hot – I love em'! They're especially good in this yummy Lentil Salad.More


text:
England battled their way back from 3-1 down in normal time to force the extra period with a hat-trick from Simon Mantell, but when it came to the shoot-out the New Zealanders came out on top. Adam Dixon saw England's third penalty saved by Kyle Pontifex and that proved to be the difference.
It was the second consecutive defeat on penalties for England, who had lost their semi-final against India in the same fashion.
New Zealand started the stronger with Shea McAleese forcing a fine save out of James Fair in the eighth minute, but a minute later Dean Couzins put the Kiwis in the lead from a penalty stroke.
England recovered well and almost equalised two minutes later when Glenn Kirkham's effort was saved by Pontifex and Ashley Jackson rammed the rebound into New Zealand captain Phil Burrows on the post. But New Zealand went further ahead in the 15th minute when Nick Haig rounded off a sweeping move to fire home from the right side of the area.
New Zealand twice missed the chance to further increase their advantage from penalty corners and paid the price when England reduced the deficit, James Tindall helping a Mantell cross over the line.
New Zealand extended their lead early in the second half when Fair illegally blocked Hugo Inglis cutting into the box, Hayden Shaw sweeping home the resulting penalty stroke.
Dixon and Jackson both missed the chance to reduce the deficit from penalty corners before England got a temporary advantage when Steve Edwards was yellow-carded for a foul on England captain Barry Middleton.
England took full advantage, reducing the deficit when Mantell flicked home a low ball into the box before completing his hat-trick by sweeping low past Pontifex.
Heading into golden goal extra-time, the Kiwis got the first chance when Simon Child's ball into the box struck the foot of Glenn Kirkham and earned a penalty corner, but the shot was saved by Fair. England got their chance from a penalty corner at the end of the first period but Richard Mantell saw his effort blocked on the line.
- More about:
- Australasia
- New Zealand


text:
Violent protests across Egypt marking the second anniversary of the Tahrir Square uprising underline the depth of the crisis confronting the unpopular Muslim Brotherhood regime led by President Mohammed Morsi. After two years of turmoil, the government of the Arab world's most influential nation -- one pivotal to Middle East peace -- is having an uphill battle to assert its authority and re-establish public order, and for that Mr Morsi and his Islamist colleagues have only themselves to blame.
Read Full Article »


text:
- About Us
- Solution Areas
- Mobile Security & Collaboration
- Advanced Persistent Threats (APT's)
- Cloud Security Services
- Data Protection and Encryption
- Anti-Malware, Anti-Virus, Anti-Spam
- Agentless A/V for VMware
- EMC Storage Anti-Malware
- Email Server Anti-Malware
- Endpoint Anti-Malware Suites (Physical Desktops & Laptops)
- NetApp Storage Anti-Malware
- Perimeter Anti-Spam and Anti-Malware
- Server (Physical) Anti-Malware
- SharePoint Anti-Malware
- SmartPhone Anti-Malware
- VDI (Virtual Desktop) Anti-Malware Suites
- Virtual Server Anti-Malware
- Data Center, Virtualization & Cloud Security
- Citrix Xen Anti-Malware and Security
- File System Integrity Monitoring
- Microsoft Hyper-V Anti-Malware and Security
- Server (Physical) Anti-Malware and Security
- System and Security Platform Management
- Two Factor Authentication
- VDI (Virtual Desktop) Anti-Malware and Security
- VMware Anti-Malware and Security
- Virtual Patching
- Laptop/Desktop Privacy & Security
- Perimeter Security-UTM
- Cloud Services
- Webinars & Events
- Knowledge Base
- Escalade IT Blog
Server (Physical) Anti-Malware and Security
Escalade IT is proud to partner with one of the world's top anti-malware solution providers to offer you centrally managed server protection for Microsoft Windows and Novell NetWare.
Virus, spyware and rootkit protection are at the core of this technology that will ensure that your enterprise servers are protected from malware infection. Large organizations may have hundreds or thousands of individual server machines that require monitoring, configuration, and maintenance.
Our solution scans and detects malware in real-time and incorporates cleanup capabilities to help remove malicious code and repair system damage. Additional functionality can be added to provide intrusion detection and prevention, firewall, integrity monitoring, and log inspection. If PCI-DSS is a part of your compliance concerns then this solution is a must see.
Contact us now to further discuss our Anti-Malware solutions for Microsoft Windows and Novell NetWare servers.


text:
|Home | About | Journals | Submit | Contact Us | Français
Coronary endothelial function (endoFx) is abnormal in patients with established coronary artery disease (CAD) and was recently shown by MRI to relate to the severity of luminal stenosis. Recent advances in MRI now allow the non-invasive assessment of both anatomic and functional (endoFx) changes that previously required invasive studies. We tested the hypothesis that abnormal coronary endoFx is related to measures of early atherosclerosis such as increased coronary wall thickness (CWT).
Seventeen arteries in fourteen healthy adults and seventeen arteries in fourteen patients with non-obstructive CAD were studied. To measure endoFx, coronary MRI was performed before and during isometric handgrip exercise, an endothelial-dependent stressor and changes in coronary cross-sectional area (CSA) and flow were measured. Black blood imaging was performed to quantify CWT and other indices of arterial remodeling. The mean stress-induced change in CSA was significantly higher in healthy adults (13.5%±12.8%, mean±SD, n=17) than in those with mildly diseased arteries (-2.2±6.8%, p<0.0001, n=17). Mean CWT was lower in healthy subjects (0.9±0.2mm) than in CAD patients (1.4±0.3mm, p<0.0001). In contrast to healthy subjects, stress-induced changes in CSA, a measure of coronary endoFx, correlated inversely with CWT in CAD patients (r= -0.73, p=0.0008).
There is an inverse relationship between coronary endothelial function and local CWT in CAD patients but not in healthy adults. These findings demonstrate that local endothelial-dependent functional changes are related to the extent of early anatomic atherosclerosis in mildly diseased arteries. This combined MRI approach enables the anatomic and functional investigation of early coronary disease.
Coronary atherosclerosis results in anatomic changes involving increases in coronary wall thickness (CWT) and later luminal stenosis, as well as functional changes such as reduced endothelial-dependent coronary vasoreactivity.1, 2 Although both anatomic and functional changes are important indices of coronary atherosclerosis, their assessment has traditionally required invasive techniques and thus any relationship has not been delineated non-invasively in patients with early coronary atherosclerosclerotic disease, nor studied in healthy and low-risk populations.1, 3
Both anatomic and functional changes of the coronaries can now be measured non-invasively using magnetic resonance imaging (MRI). Early anatomic changes in the development of atherosclerosis include outward arterial remodeling with relative preservation of the lumen.4 Because thickening of the vessel wall precedes luminal narrowing, the degree of CAD may be underestimated with conventional, x-ray angiographic imaging of the coronary lumen.5 Using black blood MRI techniques, early increases in the coronary vessel wall thickness can be visualized6, 7 and both vessel wall thickness and area quantified,8 enabling the non-invasive detection of subclinical coronary atherosclerosis.
Abnormal coronary endothelial vasoreactivity is a functional vascular change, which predicts late cardiovascular events. 9-14 Our current understanding of coronary endothelial biology and its relationship to atherosclerotic development and progression in humans is limited, primarily because invasive imaging techniques were previously required. However, we recently developed high-field MRI methods capable of quantifying coronary endothelial vasoreactivity non-invasively with good reproducibility.15 This technique demonstrated abnormal coronary endothelial function in patients with coronary disease that, in a given patient, is heterogeneous and related to the extent of local stenotic disease.15 Luminal stenosis develops late in the atherosclerotic process and although abnormalities in endothelial function have been observed invasively in patients with mild stenotic disease,16 the extent to which both anatomic and functional changes of the coronary arteries are related in early atherosclerosis is unknown. Therefore, by means of previously described non-invasive MRI methods to assess endothelial-dependent coronary vasoreactivity15 and CWT,6,7 as one of the earliest indices of anatomic coronary atherosclerosis, we sought to test the hypothesis that local coronary endothelial vasoreactivity is inversely related to local coronary wall thickness and other indices of positive arterial remodeling in early, mildly diseased coronary arteries.
Subjects were outpatients with no contraindications to MRI. Healthy subjects were those under age 50 years without a history of coronary artery disease (CAD) and traditional CAD risk factors, and for those over age 50 with an Agatston coronary artery calcium score17 <10. CAD subjects were individuals with no unstable coronary syndromes and no history of myocardial infarction who had mild coronary artery disease (<30% maximum stenosis) in the vessel imaged (and <50% maximum stenosis in other coronaries) documented on coronary x-ray angiography performed within 8 months of the MRI exam. The subjects in the study were recruited consecutively de novo and were not a subset of subjects reported in prior published studies. The protocol was approved by the Institutional Review Board at Johns Hopkins University School of Medicine and complies with the Declaration of Helsinki. All participants provided written informed consent.
A commercial human 3T MRI scanner (Achieva, Philips, Best, NL) with a 32-element cardiac coil for signal reception was used. MRI was performed in the morning after an overnight fast and before administration of prescribed vasoactive medications. Images were taken perpendicular to a proximal, linear segment of the coronary artery best identified on survey scans and without stenosis by invasive coronary angiography (Figure 1, A). When the image quality on the survey scan was equivalent for the RCA and LAD, both arteries were imaged and analyzed. To ensure slice orientation perpendicular to the coronary artery, double oblique scout scanning was performed as previously reported.18 The imaging plane for both endothelial function and wall thickness measurements was localized in a proximal or mid arterial segment that was straight over a distance of approximately 2 cm. All acquisitions were performed during a pre-specified period of least cardiac motion.19
Cross-sectional anatomical20 and flow velocity encoded spiral MRI21 were performed using single breath-hold cine sequences.22 Black blood coronary vessel wall imaging was performed at rest. For endothelial function imaging, alternating anatomical and velocity-encoded images were collected at baseline and during 4½ minutes of continuous isometric handgrip exercise as previously described.15 Each subject performed sustained isometric handgrip exercise using an MRI-compatible handgrip dynamometer (Stoelting, Wood Dale, IL, USA) at 30% of their maximum grip strength23 while under direct supervision. Heart rate and blood pressure were measured throughout using a non-invasive and MRI-compatible ECG and blood pressure monitor (Invivo, Precess, Orlando, FL, USA). The rate pressure product (RPP) was calculated as systolic blood pressure × heart rate.
For the assessment of endothelial function, the temporal/spatial resolution for the anatomical images was 15ms/0.89×0.89×8.0mm3 and 34ms/0.8×0.8×8mm3 for the flow velocity images with velocity encoding of 35cm per second. Approximately 15-22 cardiac phases were acquired for the coronary flow scan, depending on heart rate. The radiofrequency (RF) excitation angle was 20°, 17 spiral interleaves were acquired and all scans were prospectively triggered. For coronary vessel wall imaging, black-blood dual-inversion spiral imaging was used with a heart rate-dependent inversion time.24 MRI parameters were: echo time =0.84 ms, spectrally selective fat suppression, breath-hold duration~15-23sec, acquisition window=21ms, spatial resolution (acquired/reconstructed) = 0.6×0.6×8.00mm3 /0.49×0.49×8.00 mm3 and an RF excitation angle=45°. A 45° spectral spatial RF excitation angle was used because it led to the highest visual vessel conspicuity when compared to higher flip angles and is preferred at higher heart rates. The total duration of the MRI was 35-40 minutes.
Images were analyzed for cross-sectional area changes and coronary wall thickness using a semi-automated software tool (Cine version 3.15.17, General Electric, Milwaukee, WI, USA) after being magnified four-fold. A circular region-of-interest was manually traced around the coronary artery in diastole during the period of least coronary motion. The coronary cross-sectional area was then automatically calculated using a full width half maximum computer algorithm, which was shown to be highly reproducible with good inter- and intra- observer variability on blinded analysis.15,25 For the black blood coronary cross sectional images, semi-automated measurements were made of the inner and outer vessel borders (Cine, version 3.15.17) to determine total vessel wall area and mean vessel wall thickness using the full width half maximum algorithm. The normalized wall index (NWI), a measure of arterial remodeling which accounts for differences in vessel size, was calculated by dividing the wall area by the total vessel area.26
For flow measurements, images were analyzed using semi-automated commercial software (FLOW Version 3.0, Medis, NL). Peak diastolic coronary flow velocity was used for the velocity measurement to avoid adverse effects of motion blurring and because through-plane motion of the coronaries is minimized during diastole. Coronary artery blood-flow (in ml/minute) was calculated using the adapted equation (to convert units to mL/minute) as coronary artery cross-sectional area × coronary artery peak diastolic velocity × 0.3.27
Data are expressed as mean values ± one standard deviation. Paired Student's t-tests were used to compare baseline and stress coronary artery cross-sectional area, diastolic coronary flow velocity and blood-flow measurements. Student's unpaired t-tests were used to compare the changes from rest to stress in coronary cross-sectional area, peak diastolic coronary flow velocity, blood-flow measurements and hemodynamic variables between the healthy and CAD subjects as well as to compare coronary wall thicknesses between the two groups. Linear regression analysis was performed to assess the relationship between continuous variables of coronary vasoreactivity, age, body mass index (BMI) and the anatomic atherosclerosis indices of coronary wall thickness and normalized wall index. We performed separate univariate regression analysis to assess the relationships of the independent variables coronary wall thickness and normalized wall index with the outcome variable, coronary vasoreactivity (% change in CSA with stress) in the two groups. We also performed separate, univariate linear regression models to assess the relationship between the independent variable of age with the outcome variable, coronary wall thickness in the healthy population. The data were tested for normality using the Shapiro-Wilk test and the results indicated that parametric testing was appropriate. Statistical Package for the Social Sciences (SPSS) 12.0 for Windows was used for statistical analyses. Statistical significance was defined as a two-tailed p-value <0.05.
All subjects completed the study without complication and no subject was excluded prior to the MRI exam. One CAD patient and one healthy volunteer were excluded from the analysis of coronary flow velocity because of poor image quality related to patient motion. A total of 17 arterial segments in 14 CAD patients and 17 segments in 14 healthy volunteers were analyzed. Baseline characteristics of the study population are shown in the Table.
Isometric handgrip exercise induced significant hemodynamic effects in both healthy subjects and those with CAD. In the healthy group, we observed a 9.6% increase in mean systolic blood pressure (p<0.0001 vs. baseline, N=14 subjects) and a 15.7% increase in mean heart rate with stress (p=0.001) while in CAD patients (N=14), the increases were 9.2% and 17.0%, respectively (both p<0.001 vs. baseline). The RPP increased by 28% with handgrip stress (p<0.001) in healthy subjects to 10784±2358mmHg*beats/minute, and by 28% (p<0.0001) in CAD patients, to 11335±1046mmHg*beats/minute. Absolute RPP during stress and the percent increase in RPP from baseline did not significantly differ between healthy subjects and CAD patients.
In the healthy group, coronary arteries dilated significantly with stress (baseline coronary CSA, 11.1±3.4 mm2 vs. stress, 12.6±4.2 mm2, p=0.002, N=17 arteries in 14 subjects) whereas in the CAD group, the coronary CSA did not significantly change with stress (baseline area, 13.8±3.5 mm2 vs. 13.5±3.7 mm2, p=0.80, N=17 arteries in 14 subjects). The percent change in stress-induced CSA was significantly higher in healthy subjects (13.5±12.8%) than in those with CAD (-2.2±6.8%, p<0.0001, Figure 2A). The baseline coronary CSA was higher (although not significantly) in patients with CAD (13.8±3.5 mm2) than in healthy subjects (11.1±3.4 mm2, p=0.07). Coronary area measurements (% CSA change with stress) showed excellent intraobserver agreement (r =0.99, P<0.001) and interobserver agreement (r = 0.98, P<0.001) similar to prior published observations.15
Peak diastolic coronary flow velocity increased in healthy subjects with stress (baseline velocity, 20.9±5.2 cm/s vs. stress 25.8±7.3 cm/s, p=0.0009, N=17) whereas there was no significant change in peak diastolic velocity in CAD subjects (baseline velocity 21.7±5.0 cm/s vs. stress 21.3±6.1 cm/s, p=0.87, N=17). The relative exercise-induced change in peak diastolic coronary flow velocity was also greater in healthy subjects (+23.4±23.0%) than in CAD patients (-1.8±11.0%, p<0.001).
In healthy subjects, coronary blood-flow increased significantly with isometric handgrip (71.5±34.5 ml/minute vs. 98.4±46.3 ml/minute, p=0.0002, N=17), while blood-flow was not significantly changed with stress in CAD patients (91.5±38.1ml/minute vs. 88.5±41.5ml/minute, p=0.83, N=17). The percentage change in coronary blood-flow changes with stress was significantly greater in the healthy group (+37.6±31.7%) than in the CAD group (-4.3±13.0%, p<0.0001, Figure 2A).
Mean coronary wall thickness was significantly greater (1.4±0.3mm) in patients with mild CAD than in healthy subjects (0.9±0.2mm, p<0.0001 healthy vs. CAD, Figure 2B, N=17 each group) as was the mean coronary vessel wall area (19.8±5.6 mm2 vs. 11.5±3.0 mm2, p<0.0001). The normalized wall index (NWI), a marker of positive arterial remodeling, was also significantly higher in CAD patients (0.72±0.08, N=17) than in the healthy group (0.59±0.08, p=0.0009, N=17). Consistent with prior observations,28,29 wall thickness measurements showed excellent intraobserver (r =0.99, P<0.001) and interobserver agreement (r = 0.98, P<0.001).
In the entire population of healthy adults and CAD patients combined (N=34 arterial segments), there was a significant relationship between CWT and % coronary artery area change with stress (r=-0.64, p<0.0001, Figure 3). However, in the healthy group alone we observed no significant relationship between CWT and % CSA with handgrip stress (r= -0.19, p=0.47, Figure 4A). In contrast, in the CAD patient group, there was a strong inverse relationship between CWT and % area change with stress (r= -0.73, p=0.0008, Figure 4B). The significant relationship between the two parameters persisted even after excluding those CAD patients whose endothelial function was in the top and bottom 10% of the group (r = -0.67, p=0.001). Similarly, there was no significant relationship between NWI and stress-induced % CSA change in healthy subjects (r= -0.11, p=0.67), while we observed a strong inverse relationship between NWI and % CSA change in the CAD patients (r= -0.67, p=0.003, Figure 5).
There was no significant relationship between CWT and % coronary velocity change with stress in either healthy adults (r= -0.10, p=0.66) or CAD patients (r= -0.23, p=0.37, Figure 4). Although there was a significant inverse relationship between CWT and % coronary flow change with stress in CAD patients (r= -0.58 p=0.01), this was not observed in healthy subjects (r= -0.19, p=0.46).
Because of the small sample size, multivariate analysis with respect to coronary risk factors and age could not be performed, although univariate linear regression analysis of the healthy subjects indicated a significant correlation between age and CWT (r= 0.66, p=0.009). A comparison of a subset of the seven oldest healthy subjects (mean age 54.9 ± 10.9) with CAD patients (mean age 59 ± 7.0 years, p=0.75) still showed significant differences in both CWT and % CSA change with stress between the mild CAD and healthy age-matched group (mean CWT=1.06 ± 0.2mm healthy, p=0.01 vs. mild CAD CWT; % CSA change with stress=9.0% ± 9.7, p=0.03 vs. mild CAD % CSA change with stress).
This study demonstrated that abnormal coronary endothelial function and increased coronary wall thickness can be detected during a single, non-invasive 3T MRI exam and, importantly, that abnormal coronary endothelial-dependent vasoreactivity is present locally in mildly diseased coronaries and related to the earliest non-invasive in vivo measure of local coronary atherosclerosis, an increase in coronary artery wall thickness. We previously reported that coronary endothelial function was closely related to the degree of luminal stenosis.15 Our current pilot study in patients with non-obstructive CAD demonstrate that local functional and anatomic changes of the coronary arteries are closely related in early atherosclerosis, before the development of significant luminal stenoses, a late occurrence in the progression of atherosclerotic disease.
The present study detected significantly higher mean coronary wall thickness, wall area, and normalized wall index in patients with mild CAD compared to those of healthy subjects. This increase in wall thickness in CAD patients relative to healthy subjects and preservation of luminal area is indicative of positive arterial remodeling.4
The values for coronary wall area, wall thickness, and coronary endothelial function reported here are similar to those previously reported using MRI6-8, 15 and invasive techniques2, 10, 30-32 in separate studies, although the endothelial-dependent stressors varied across studies. The observation that mild structural and/or functional coronary disease may contribute to reduced endothelial-dependent coronary flow supports earlier PET vasomotor flow studies.33, 34 However, the ability to measure both vessel wall remodeling and endothelial-dependent coronary vasoreactivity in a single non-invasive exam, demonstrated here for the first time, enables a more complete measure of early atherosclerotic disease than previously possible. Finally, the length of the coronary protocol makes it feasible to combine the imaging sequence with an MR evaluation of left ventricular structure or function, leading to a more comprehensive cardiac exam.
In a recent report, abnormal coronary endothelial function varied among arteries in a given CAD patient and was related to the severity of luminal stenosis.15 The observation here that coronary wall thickness and local endothelial function are associated in patients with mild, non-stenotic CAD is novel and demonstrates that anatomic and functional early atherosclerosis not only co-exist in coronary arteries but are also closely related. Although structural alterations in the arterial wall may impair flow-mediated epicardial vasodilation, we previously showed that the administration of nitroglycerin to patients with significant CAD dilated the same arteries that constricted with isometric handgrip exercise.15 That demonstration that endothelial-independent mechanisms are intact shows that the likely mechanism for impaired epicardial vasodilation during isometric handgrip exercise is likely endothelial dysfunction rather than a mechanical disturbance such as may occur with heavy coronary calcification, especially in these patients with very mild atherosclerosis.
In contrast to the findings in CAD patients, there was no relationship between coronary endothelial function and CWT in healthy subjects. Though prior work demonstrated that stimuli like tobacco abuse or high circulating lipids35,36 can induce transitory abnormal endothelial function in healthy subjects, all such stimuli were avoided here by protocol design.
Although our study detected a relationship between endothelial-dependent coronary vasodilation (area change) and wall thickness in arteries with mild atherosclerosis, we found no apparent relationship between coronary velocity change with stress and early anatomic atherosclerosis in either group. These findings suggest that early local anatomic atherosclerotic changes are more closely related to measures of, and therefore, local coronary endothelial function (e.g. area change within the same epicardial coronary segment) than to endothelial function measures which incorporate non-local parameters (e.g. coronary flow velocity).
The extent of early anatomic atherosclerosis and endothelial function has been well characterized in peripheral arterial beds.37, 38 Several previous studies evaluated the relationship between brachial endothelial function (flow mediated dilation) and carotid intimal medial thickness using B-mode ultrasound and reported varying results.37-39 Although earlier studies found a positive relationship between carotid intimal medial thickness and peripheral endothelial function,37 more recent studies found no significant correlation between the two parameters.38, 39 Those findings may be explained by the fact that different vascular beds were evaluated for anatomic and functional measurements of atherosclerotic disease.
Although atherosclerosis is a systemic process, studies of different vascular territories have shown that vasoreactivity may not be uniform across vascular regions within the same individual. One study using MRI compared changes in flow and vessel radius before and during post-occlusion hyperemia in the upper (brachial) vs. lower (femoral) extremities and found that femoral but not brachial reactivity was impaired in patients with increased cardiovascular risk.40 Other data suggest that peripheral and coronary endothelial function measures may not be strongly related41, 42 possibly due to differences in vascular properties.43 Moreover, acute brachial arterial plaque rupture rarely occurs in contrast to acute coronary plaque rupture. Although peripheral and coronary endothelial vasoreactivity have not been directly compared using the same stressor and imaging modality, our previous data show significant heterogeneity of coronary endothelial function within the coronary tree.15 Thus, the non-invasive measurement of coronary endothelial function is likely more relevant for defining factors related to local coronary artery atherosclerosis and plaque progression.
In vivo human studies evaluating coronary endothelial function and its relationship to early vessel remodeling have not been performed before, likely because invasive techniques were required. The most commonly used technique to identify positive coronary arterial remodeling has been intravascular ultrasound (IVUS).44,45 Traditionally, studies of coronary endothelial function have been performed during x-ray coronary angiography with acetylcholine or cold pressor testing as the endothelial-dependent stressor.2, 9 Those techniques, however, are not suitable for screening low risk and asymptomatic populations because of their invasive nature and associated risk. Although multi-detector computed tomography (MDCT) has been used to assess positive remodeling and plaque progression in patients with CAD,46 the exposure to ionizing radiation and contrast media limit repeated studies and its use in low risk populations. It is also unable to measure coronary velocity or flow for the assessment of endothelial function. Black blood coronary wall MRI can detect coronary arterial wall changes indicative of positive arterial remodeling6, 7 with good reproducibility.28, 29 Moreover, MRI studies of the coronaries may be safely applied to low risk populations to noninvasively quantify coronary vessel wall dimensions and to measure endothelial dependent vasoreactivity. There were no noteworthy variations in image quality with respect to BMI, heart rate or other clinical parameters and the sequences performed equally well with the RCA and LAD in most cases. Lastly, in our study, the use of an MRI contrast agent (gadolinium) was not necessary, which offers the ability to safely study patients with renal insufficiency.
One limitation to the current study is that the spatial resolution of MR imaging of the coronaries is not able to distinguish separate layers of the vessel wall or plaque components. Therefore, radiofrequency intravascular ultrasonography determination of early anatomical changes in the coronary arterial wall may be more sensitive at detecting and characterizing early disease than MRI, however, we were not able to ethically justify the risk associated with invasive coronary procedures in healthy and low risk subjects studied here as an alternative validation approach. In addition, we are currently limited in the choice of the coronary segment that can be imaged. Although we primarily focused on proximal and mid coronary segments of the RCA or LAD to evaluate stress-induced area changes, the ability to also measure coronary velocity and flow permits a more global assessment of downstream endothelial function that complements the measurement of local epicardial vasoreactivity. Therefore, technical developments designed to improve spatial resolution and volumetric coverage will likely advance endothelial function studies and permit greater flexibility in the choice of the imaging plane and local characterization of plaque morphology. Another limitation to this pilot study is the relatively small sample size. However, with only 34 coronary arteries investigated, we observed significant differences in both positive arterial remodeling and vasomotor responses to a known endothelial-dependent stressor between healthy and CAD subjects. Lastly, the two groups were not age-matched. However, on further statistical analysis of a subset of healthy subjects age-matched to the CAD patients, significant differences in CWT and exercise-induced change in CSA were still observed between mild CAD patients and healthy age-matched controls. Because of the small sample size, multivariate analysis with respect to coronary risk factors and age could not be performed.
In summary, the present findings demonstrate that local coronary endothelial function is inversely related to local positive arterial remodeling in patients with non-obstructive CAD. These findings indicate that early non-stenotic atherosclerosis is associated with abnormal local endothelial function and therefore that anatomic and physiologic indicators of coronary vascular pathology are related in patients at the earliest stages of coronary atherosclerosis that can be detected non-invasively in humans. Moreover, it would be feasible to combine this imaging protocol with an MRI evaluation of left ventricular function, leading to a more comprehensive evaluation of cardiac risk. This may contribute to improved detection and monitoring of atherosclerotic disease and its response to therapy at an early, preclinical stage as well as the ability to non-invasively investigate anatomic and functional predictors of disease progression.
This study demonstrates, for the first time 1) that abnormal coronary endothelial function and increased coronary wall thickness can be detected during a single, non-invasive 3T MRI exam and 2) that abnormal coronary endothelial-dependent vasoreactivity is present locally in mildly diseased coronaries and related to the earliest non-invasive in vivo measure of local coronary atherosclerosis, an increase in coronary artery wall thickness. Thus in a given coronary artery segment, early anatomic markers of coronary atherosclerosis are closely linked to functional markers in that segment that may occur long before the development of severe stenotic disesase. The ability to non-invasively and without contrast evaluate both structural subclinical atherosclerosis and coronary endothelial function provides an opportunity to evaluate both aspects of the coronary response to therapeutic intervention. This may also contribute to improved detection and monitoring of atherosclerotic disease and its response to therapy at an early, preclinical stage as well as the ability to non-invasively investigate anatomic and functional predictors of disease progression.
The authors thank Angela Steinberg, RN and Rob van der Geest, PhD for their assistance and the patients and healthy volunteers for their participation in this study.
Sources of Funding
This work was supported by National Institutes of Health [R01-HL084186, ARRA 3R01-Hl084186-04S1, R01-HL61912], and by the Donald W. Reynolds Foundation and the Clarence Doodeman Endowment. Dr. Kelle is supported by a scholarship from the German Cardiac Society. Dr. Hays is supported by a grant from the American Heart Association.
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


text:
I have visited Bocas yearly since 2006. Accommodations are incredible! Marlin is an outstanding host and chef too! Local foods are cooked to perfection. Marlin provides the unique Bocas experience whether it be snorkeling, fishing or exploring secluded islands. Can't wait to return!
- Official Description (provided by the hotel):
- Cayo Del Sol is a private island with stunning views surrounded by water, birds and other wildlife just 15 minutes from Bocas Town. We offer 2 suites with king size beds. Each room has a private bath with hot water shower and observation deck. Your stay comes with breakfast each morning of eggs, toast, fruit, juice and coffee. We will also pick you up in Bocas Town and give you one complimentary boat ride per day to either Bocas Town or Red Frog Beach. Other tours and full day rental of the boat with captain are available. The rate is only $75 per person per day based on double occupancy. ... more less


text:
Teen dead following early morning road collision
Gardai have launched an investigation after a 13-year-old boy died following a road crash this morning.
It is believed that the young teen was involved in a car that was involved in a single car collision at 6.40am this morning.
The youth and an adult male walked away from the crash but he subsequently collapsed on the road nearby.
Emergency services were called and the teenager was pronounced dead at the scene. His remains have been brought to Loughlinstown Hospital.
The road between Annamoe and Roundwood remains closed to traffic this morning and traffic diversions are in place.
A forensics team is at the scene and a full garda investigation is underway.
More following


text:
The Sword of Gravalan was held for many years by the Wizard of the Lake.[1]
The sword is made of bronze, but as strong as steel. The tip can become white hot if the hilt is twisted correctly, but the sword stays dark even when in this state. The sword was made long ago by skilled crafts-people, perhaps the Dwarfs. However, Gravalan is the name of the Goblin hero who defeated the Portal thousands of years ago, when the Goblin civilisation was at a peak of sophistication and culture, conveniently forgotten by the Men of Khul.
See AlsoEdit
- ↑ Portal of Evil - ???


text:
Uniontown, Ohio – (The Hosting News) – May 22, 2007 – Web design and development firm, Equentity LLC, has launched its hosting subsidiary, Equentity Host, offering cPanel-based Shared, Reseller and Dedicated hosting solutions. The company has provided hosting services privately to its customers for the past several years, but today begins a public marketing campaign to promote its web hosting offerings and attract new customers.
Equentity Host will market its premium hosting services to a variety of customers, including hosting resellers and small businesses. It offers plans for customers of all sizes and budgets, with shared hosting plans ranging monthly from $4.95 to $25.95 and reseller plans from $12.95 to $89.95. Dedicated servers start at $189.95, and Equentity Host has built a personalized server configurator, allowing customers to create custom servers to suit their needs.
Paul Hirsch, Co-founder of Equentity remarked, "We're focused on providing premium plans that reflect the need in the industry for quality, not simply the lowest priced hosting solutions. We are confident our pricing structure remains competitive and reflects the care we exercise in attending to the needs of our customers and the hosting environments in which they are housed."
Equentity Host also unveiled EqRewards, an exciting and unique program designed to reward customers for their loyalty. Hosting and dedicated server customers earn points for every dollar they spend with the company, as well as point bonuses at certain dates-of-service milestones, such as the one-year anniversary of their sign up. Accumulated points can then be redeemed in a variety of ways. They can be used to purchase hosting vouchers, which can be applied toward their hosting invoices. Customers can also exchange points for various retailer and restaurant gift cards, or convert points into donations toward charities or organizations of their choosing. Customers who have amassed enough points will be able to take part in the Executive Rewards Program, featuring big-ticket rewards such as watches, jewelry, artwork, plane tickets and vacation packages. Equentity Host customers are automatically enrolled in this unique rewards program, making it easy to accumulate and spend their EqRewards points.
Equentity LLC is a web design and development firm, founded in 2005 by three internationally located web developers and marketing specialists. The company is owned and operated by Ohio-based Paul Hirsch, and United Kingdom-based Jamie Harrop and Paul Riddick. Its clients include businesses, organizations and individuals in northeast Ohio, as well as customers throughout the United States and the United Kingdom.
To learn more about Equentity Host, please visit: www.equentityhost.com.
For more information about the Equentity Host customer rewards program, please visit: www.equentityhost.com/rewards.


text:
Buy discounted gift cards to Ocean Prime, the steak and seafood restaurant that's modern, social and electric. Located in metropolitan areas like New York, Boston, Dallas, and Washington, D.C., Ocean Prime is the place to go for a special night out—a business dinner, celebratory cocktails or a romantic meal. You'll savor the food, the service and the extensive wine list.
CardCash is the largest gift
card exchange in the world.
Turn unused gift cards into cash
or buy discount gift cards with the
safety and security of our 45 day
card balance guarantee.


text: The Gestation period in a viviparous animal is the length of its gestation. In humans this is 266 days (38 weeks), but varies for other animals. Gestation period is measured from conception to birth. See alsoEdit pregnancy Retrieved from "http://psychology.wikia.com/wiki/Gestation_period?oldid=73424" Ad blocker interference detected! Wikia is a free-to-use site that makes money from advertising. We have a modified experience for viewers using ad blockers Wikia is not accessible if you've made further modifications. Remove the custom ad blocker rule(s) and the page will load as expected. Categories: Add category Cancel Save


text:
To the Editor:
Samuel G. Freedman, in his article ''Suburbia Outgrows Its Image in the Arts'' [Feb. 28], wrongly defines John Cheever's so-called suburban stories as depictions of a ''miserable, materialistic dystopia.'' In Cheever's own preface to the collection ''The Stories of John Cheever'' (Knopf, 1978), he wrote, ''The constants that I look for in this sometimes dated paraphernalia are a love of light and a determination to trace some moral chain of being.''
The suburban landscapes that do appear in Mr. Cheever's fiction are, if anything, the ironical appendages of his characters' stumbling attempts to capture whatever Arcadian shreds of light and moral being may still beckon. Cheever's real story is that of his characters' troubled sense of some primordial Fall From Grace. The suburb is the setting for these struggles, not an environmental cause.
Yakima, Wash.Continue reading the main story


text:
My chest is throbbing with deep purple bruises that should very well be gunshot wounds. Every breath that passes through these blackened lungs feels as if I'm swallowing fire. Maybe I have a couple of cracked ribs, it's no big deal really.
But they didn't get me, Mello.
Nothing else exists right now. No buildings, no streets, no sky, no people. You will be the only thing I'll ever allow myself to see in this endless white void. I'm running as fast as my body will allow, wrecklessly searching. Searching for you as the smoke fades and the ashes settle. Searching for you like I'd done my entire life. You're so close. I can feel it like a hand wrapped around my throat, like a vice slowly crushing my insides and extracting my very last breath.
There you are, Mello.
I immediately try to stop, but my injuries have dulled my reflexes and the momentum I've built up sends me crashing to my hands and kness before you. And in the space of a second, in that very moment I gaze into those pale eyes and know there's nothing left in them, I truly begin the beautiful process of dying. Some say that process begins the moment you're conceived, that life just bleeds out of you from the start. They're wrong. So wrong. My life began the moment my name graced your lips, my beloved friend, and it will end with your name on mine.
But something is not right. I glance up and see her in the distance, completely motionless and staring. This is all her fault. She was the one who wrote you away from me, my Mihael Keehl. She doesn't belong here. I'll make her go away.
I'll do it for you, Mello.
I'm not certain how I ended up on top of her, it's all such blur. But right now I'm pressing all of my weight onto my hands as they close tighter and tighter around her neck. She fights and flails and struggles beneath me, but a few quick skull bashes into the ground make her easier to manage. I can feel something crumple and break against my grip, and her body finally stills. That last little gasped breath before her trachea is destroyed, I lean in close and steal it right out of her mouth. Her eyes gaze into mine with the same vacant expression as yours now. I hope she can still see me somehow, I want her to see this almost joyous grin twisted across my lips before she goes off to burn. Slowly, I roll off of the "goddess", like so many other men have done before me I'm sure, and crawl back to my rightful place by your side.
I collapse beside you, laying the way I would as if we were safe in our bed. You're laying on your back, arms and legs splayed out, head turned in my direction. I rest my head on your shoulder, remembering how this should feel. Warm and alive, your arms should be wrapping around me by now. I try to convince myself that if I stare long enough, I'll be able to see the slow rise and fall of your chest as I lay here with you. That always put me to sleep before. It's been such a long day and I just want this to be over. We can both just go to sleep and wake up tomorrow. Together, the way it should be.
Just you and me now, Mello.
You still have the gun, tucked neatly into the waist of your pants. I reach over and take it from you, my finger gently stroking the trigger as I ease the cold, black metal upward. Is this what it makes you feel? Is this almost serene sensation building in the back of my head what you experience as you hold this thing? The power to erase someone's very existence, right in the palm of my hand. It feels a bit strange, scraping against my teeth and the roof of my mouth. I can hear your voice in my head now, begging me not to leave you alone, pleading with me to go with you. My finger tenses. And then I feel the most glorious spark as it flashes and crackles behind my eyes.
Don't be afraid, Mello.
My memories splatter against the ground in a myriad of red, grey, and white as the gun drops between us. Your favorite color is black, our first kiss, you bought me the entire Street Fighter collection for my birthday two years ago, I hate it when you chew with your mouth open, the last time you told me you loved me... Memories I won't need anymore. I'll give them all to this vast white void as it swallows me whole.
Perhaps people are wrong about dying instantly after blowing your brains out though. Because I can still see you in these divine moments, I'm still staring deeply into your eyes. But it's different now. You're different. I open my mouth to speak, but there's only silence. Silence until those almost angelic lips of yours form words that bring tears of joy to my eyes.
I knew you'd follow me, Matt.
Author's Notes... Just a very abstract, very dark idea I had. And now I'm depressed.


text:
Samsung has produced a 12-inch tablet with a 4K Ultra HD screen - but it remains a prototype for now.
Created as a reference device for network operators to perform tests with, the tablet was spotted at an LTE Broadband event at the French Open tennis tournament. Although full specifications of the tablet are not known, TechRadar, who spotted the super slate, was told it is powered by a Qualcomm Snapdragon 801, as found in most of the newest flagship smartphones and tablets.
It is hoped that if (or when) a 4K tablet comes to the market, it will have the newer Snapdragon 805 chip, which comes with 4K-friendly features such as the ability to upscale 720p and 1080p HD video to the higher resolution.
The tablet's screen resolution was referred to as Quad HD - the same as the LG G3, which would suggest a pixel count of 1440 x 2560, or double that of a regular Full-HD display.
Source: TechRadar


text:
Everyone loves the carols of Christmas. Singing about the story of the birth of the Savior speaks to our hearts and souls. The scriptures tell that from the beginning Christmas was filled with music, from Mary's first hymn of praise to the chorus of Angels that heralded the Lord's birth.
This series of sermon messages reflects on the meaning of the very first carols of Christmas and what they tell us about our Lord, God and Savior and His purpose for us in the world.
November 25, 2012 - Go Tell It on the MountainDecember 2, 2012 - Ave MariaDecember 9, 2012 - The MagnificatDecember 16, 2012 - The BenedictusDecember 23, 2012 - The Angels' Song (Candlelight Christmas Eve)December 30, 2012 - The Song of Simeon: A Glimpse of What's to Come (Rev. Molly Simpson)
Death. It's one of those topics we prefer not to think about. Yet what we believe about death profoundly shapes how we live life. We each face death regularly – whether it is the stories on the evening news, or the loss of someone we love. Eventually we each will face our own mortality.
We have so many questions about death: What happens when we die? Is there really an afterlife? If so, what is it like? Can we talk with our deceased loved ones? Do they hear us? How do we care for those who are dying? Or comfort those who survive? What happens if someone takes their own life? And what about our bodies – do we need them in the afterlife or is cremation okay? Ultimately we want to know, how do we face our own mortality with courage and hope?
If you've lost a loved one, or simply have questions about death, you'll find this series of audio sermon helpful, inspiring and encouraging. .
June 17, 2012 Death and the Afterlife June 24, 2012 Christianity and Suicide Jul 01, 2012 Comforting Those Who Mourn (Reverend Karen Lampe)Jul 08, 2012 The Art of Dying Well (Reverend Steve Langhofer)
Travel with us on a journey retracing the life and ministry of Jesus Christ. Using video shot for this sermon series, we'll take you to the Jordan River where Jesus was baptized and to the wilderness where he was tempted. You'll see the ruins of ancient Capernaum where Jesus healed the sick. You'll ascend the mountain where he gave his most famous sermon. You'll travel across the Sea of Galilee where he calmed the wind and the waves. You'll visit the last remaining community of Samaritans in the world. And, you'll enter Jerusalem where Jesus spent his final days.
If you've ever wanted to know more about Jesus Christ, we invite you to join Reverend Adam Hamilton for this seven-part series of audio sermons walking "In the Footsteps of Jesus."
February 26, 2012 The Baptism and Temptation of Jesus March 4, 2012 Jesus' Healing Ministry in Capernaum March 11, 2012 Jesus Went Up the Mountain March 18, 2012 Who is This that Even the Storms Obey Him! March 25, 2012 The Outcasts and the Poor April 1, 2012 The Final Week in Jerusalem April 8, 2012 Your Defining Story – EASTER
Falling in love is easy, but staying in love takes courage, hard work and lots of grace. This six-part series of video sermons explores Love, Sex and Marriage and what it takes to make love last.
Reverend Adam Hamilton draws upon the results of a survey of thousands of couples and singles in the Kansas City area, interviews with couples and marriage therapists, the latest research in the field, and wisdom from the Bible. He looks at what it takes to create and sustain healthy, meaningful romantic relationships across the course of a lifetime.
January 8, 2012 More Than a Piece of Paper: The Meaning of MarriageJanuary 15, 2012 What She Wants, What He WantsJanuary 22, 2012 The Significance of Sexual IntimacyJanuary 29. 2012 Habits that Hurt, Habits that HealFebruary 5, 2012 Clothe, Bear With and ForgiveFebruary 12, 2012 A Love That Lasts a Lifetime
This five-part series of audio messages centers on several of the most well known of the stories that Jesus told. These "parables" are stories that spoke to the relentless love of God, and the meaning and purpose of life. Jesus spoke of good Samaritans, prodigal children, rich fools and unforgiving servants, lost sheep and sprouts that were choked out by weeds. With each story he answered the questions we ask in life. Jesus' parables changed his hearers 2,000 years ago. They still have the power to change our lives today.
April 15, 2012 – Making Life CountApril 22, 2012 – The Relentless Love of GodApril 29, 2012 – The Necessity of Forgiveness (Reverend Molly Simpson)May 13, 2012 – The Meaning of LoveMay 20, 2012 – Exercises in Missing the Point
Pastor Scott Chrostek shares a series of messages that will help us strip away facades and take a look at what it really means to be an authentic Christian community comprised of unique individuals whose lives have been transformed—a community that is continually renovating and rebuilding.
Version 2.0 or New Creation - May 27, 2012You Are What You Eat - June 3, 2012Words with Friends - June 10, 2012
The Bible contains some of the loftiest and most beautiful verses in literature. Millions look to it for inspiration and guidance. At the same time, some parts are confusing and others are deeply disturbing.
Did God really command violence and genocide?Was the earth really created 10,000 years ago?Are women required to be silent and subservient?Are we bound by ancient codes regarding sexuality?Are these the words of God or mortals?
This series of sermon messages seeks to answer these questions.
August 19, 2012 - Making Sense of the BibleAugust 26, 2012 - Violence and God in the BibleSeptember 2, 2012 - Dinosaurs on the Ark: The Bible and ScienceSeptember 9, 2012 - The Bible and SexualitySeptember 16, 2012 - The Reliability of the New Testament


text:
York Street gardens will close at 3 p.m. on Friday, July 21 for a concert. Other early closings.
Snowy days are some of my favorite times in the Gardens. As I stroll the paths, I feel as though I am the grande dame of a grand estate, maintained meticulously and solely for my delight.
Often on my walks I see no one else, and as I pause to listen to the chittering of a squirrel or perhaps catch a glimpse of our resident fox, I reflect that in the middle of a city of more than a million people, I am virtually alone in nature—a wondrous thing!
Even a light dusting of snow transforms every leaf, berry, and pod and makes a tired garden look fresh again.
Line and form is emphasized, and every photograph can be a work of art. Take some time to enjoy the tranquility and aesthetic of winter in the Gardens.


text:
Dolman sleeves. Optional front bow. Button front and buttons on sleeves Full skirt. Suggested fabrics: Gingham, Voile, Nylon Sheers, Linen, Crepe, Printed cottons or Silks, Shantung, Polished Cotton. Collar "A": Pique, Linen, Organdy. Bow "A" - "C": Taffeta, Polished cotton
Links to reviews/blog posts Edit
Sources/Vendors Edit
- sew betty and dot
- GrandmaMadeWithLove Size 14
Gallery Edit
[insert your photos of this pattern made up]
Wishlist Edit
[insert your username, and make sure your preferences allow for people to contact you via e-mail. Do not list your email address here!]


text:
he story of Wilson Bond, a pimp who after saving Chan, the leader of the Heaven and Earth society, a revolutionary group, is made a member. After a botched first assignment for the group, he is made a servant to the Prince, the very person the Heaven and Earth society want to overthrow. What follows is plenty of mayhem and laughter.Resumen IMDb.com
|Nombre del documento
Stephen Chow
Wei Siu Bo / Wilson Bond
Sharla Cheung Man
Empress Dowager / Long-er / Mother Queen


text:
Question about Daihatsu Charade
Posted by sdpnell on
Est site for repairing cars
hope this may help;
Posted on Jul 29, 2008
The Location of the relay are in the picture.
I hope help on your problem...
Posted on Jul 29, 2008
The fuse box is located on Left front corner of the engine comparment.
and in some models the fuel pump relay is called too injector relay.
But check the Main relay. because they depend of the main relay.
Check all the fuses. and connections.
SOURCE: I have freestanding Series 8 dishwasher. Lately during the filling cycle water hammer is occurring. How can this be resolved
a 6ya expert can help you resolve that issue over the phone in a minute or two.
best thing about this new service is that you are never placed on hold and get to talk to real repairmen in the US.
the service is completely free and covers almost anything you can think of (from cars to computers, handyman, and even drones).
click here to download the app (for users in the US for now) and get all the help you need.
Posted on Jan 02, 2017
Tips for a great answer:
Dec 11, 2016 | Toyota Cars & Trucks
Dec 10, 2014 | 1978 Chevrolet Chevette
Oct 30, 2014 | 1996 Daihatsu Mira
Dec 29, 2013 | 1993 Honda Civic 4 Door
Sep 29, 2012 | Daihatsu Mira Cars & Trucks
First you have to determine weather you
have a FUEL problem or (ELECTRICAL)Spark problem ??
Pull the coil wire off or a easy to get
to spark plug wire, Lay it close to were you pulled it off of (Do not
hold or touch you may get SHOCKED) and crank motor (need two people)
look and listen for a spark, if you see or here a spark, then go to
next step which will be to check for Fuel (gas). Be very careful when
checking fuel, as most lines are under pressure and may cause bodily
harm such as BURNS to EYES and SKIN!! Loosen or pull the inlet fuel
line off and put rag over line. Some fuel injected vehicles have a
fuel rail the has a valve that looks like a tire valve. Put a rag
over this valve and push it in with a small screw driver and have
someone crank motor a couple of times to see if fuel is coming out.
If NO Spark---Could be a lot of things
Points (older vehicles) Modules, Coils, Crank Sensors, ECT......
If NO Fuel---- Could be Clogged fuel
filter, Fuel Pump, Fuel pump Relay, Fuse, ECT..........
Hope this helps you ??
Jul 06, 2011 | Mitsubishi Diamante Cars & Trucks
Jan 21, 2011 | 1995 Eagle Summit
Jul 01, 2009 | 1990 Honda Accord
May 09, 2009 | 1993 Volvo 850
Apr 08, 2009 | 1994 Volkswagen Jetta
785 people viewed this question
Usually answered in minutes!
Level 3 Expert
22082 Answers
Level 3 Expert
74241 Answers
Level 3 Expert
4514 Answers
Step 2: Please assign your manual to a product:


text:
ha desh maza MP3
Composed by Jagtap D. A. Sir, Walchandnagar.
Utha rashtra vir ho MP3
Marathi Abhiman Geet MP3
Marathi bhashechya vikasasathi ha prayatna aahe- Kiran Bonde Aapalya pratikriya kalava : [email protected]
Samuh Geet(ha desh maza) MP3
Desh Ha Dev Ase Mazha- Asha Bhosle (Dhanya Te Santaji Dhanaji). MP3
A beautiful old Marathi film song, a desh bhakti geet, on the occasion of Independence day.
He Rashtra Devtanche Marathi Samooh Geet MP3
He Rashtra Devtanche Marathi Samooh Geet.
Gargee - Bharat maza desh ahe MP3


text:
|Message view
|« Date » · « Thread »
|« Date » · « Thread »
|Sylvain Lebresne <sylv...@datastax.com>
|Re: multithreaded compaction
|Tue, 26 Apr 2011 07:35:26 GMT
On Tue, Apr 26, 2011 at 9:01 AM, Terje Marthinussen <email@example.com> wrote: > Hi, > I was testing the multithreaded compactions and with 2x6 cores (24 with HT) > it does seem a bit crazy with 24 compactions running concurrently. > It is probably not very good in terms of random I/O. It does seems a bit overkill. However, I'm slightly curious how you ended up with 24 parallel compactions, more precisely, how did you end up with enough sstables to trigger 24 compactions ? Was that done on purpose for testing sake, or did you saw that in a real situation ? I'm asking because in 'real' situation, given that compaction are triggered only if there is some number of files to compact, and provided the cluster is correctly provisioned, I wouldn't expect the number of parallel compaction to jump to such numbers (one of the goal of multi_treaded compaction was to make sure we never end up accumulating lots of un-compacted sstables). Anyway, I get your point, just wondering if that was a real situation. > As such, I think I agree with the argument in 2191 that there should be a > config option for this. > Probably a default that is dynamic with 1 thread per column family +2 or 3 > thread for parallel compactions outside of that could be good. > Any other opinions? Multi-threaded compaction is optional and compaction throttling is supposed to mitigage it. However I do agree that too much many compactions may be a bad use of resources because of random IO even if correctly throttled. I think it's missing a configuration option "concurrent_compactions" like there is a "concurrent_writes|reads". For that, I have created https://issues.apache.org/jira/browse/CASSANDRA-2558 > I guess the compaction thread pool should also show up in tpstats? Yes it should ... and it will ... eventually :) Thanks for the feedback. -- Sylvain
|View raw message


text:
Hailing from 'The Cosmic Forest' comes disco-dance production duo Psychemagik with the Lunar Escape EP, their first digital self-release.
The EP's three tracks were written and produced by the lads themselves. You won't find any samples nor edits, but you will find a 17 piece orchestra on 'Above The Clouds,' the EP's closing track. British string arranger Richard Chester was enlisted for his services:
"The climax of the lunar escape is when you break through the clouds on your ascent to a new atmosphere."
Hit 'buy' above for a digital download of the Lunar Escape EP.
Psychemagik.com | Facebook.com/TheCosmicForest | Soundcloud.com/Psychemagik


text:
To the Editor:
I read with horror the article about the decline of family farms (''As Farm Life Worsens, the Toughest Wither,'' front page, April 2), but my horror was for the animals. I thought of the pigs, confined in small pens and bred constantly. No wonder they are susceptible to diseases and pumped up with drugs. It seems as if ''efficiency'' has led to cruelty. Most people don't care what a horrible life their dinner led, but after reading this article, I have decided to become a vegetarian.
New York, April 3, 2000Continue reading the main story


text:
Absolutes are just about resembling major oils; the lonesome distinction between them is that absolutes take more tangled procedure of activity. Essential oil is generally extracted by routine of fog activity in which nearby is a call for of cold heat. And, extracting oil from exquisite carnation is really especially problematic because uttermost fry can flatten the fluent olfactory perception and odour of the flowering plant. So, a alone route of extracting oil has been formulated to confine the olfactory property and odour of overdelicate natural part of herbs or spray (from which oil is to be extracted). This act doesn't touch on heat energy or marine etc. And, when oil is extracted by mistreatment this individual route afterwards it is termed as utter rather than central oil.
Absolutes are stronger than crucial oils. Thus, at hand is no stipulation to whip it in macro size. Absolutes are outstandingly intent. So, sometimes race can be hypersensitivity reaction to them. Absolutes dramatic composition an great role in fragrance and perfume commercial enterprise.
Absolutes are one of the important ingredients in use in aromatherapy. Aromatherapy is an art of salutary and solidification miscellaneous article worries by victimisation crucial oils, absolutes and other untaught products. These unconscious products strengthen the life plane and struggle next to mixed diseases.Post ads:
Retrofit Hooded Sweater / Burberry Eyeglasses BE2086 3001 Black 52mm / Philadelphia Flyers Claude Giroux Orange Reebok T Shirt / Geoffrey Beene Wool Herringbone Ivy Scally Cap Classic / Micros Men's The Beast Top / Stetson Open Road Fur Felt Hat / G by GUESS Titan Straight Jeans - 33 Inseam / 2(x)ist Men's Touch Ultra Contour Pouch No Show Brief / Doublju Mens Casual Single Color V neck T-shirt / Freshjive The Pipe Dreams Tee in White / District Threads Long Sleeve Thermal (DT118) Available in / Denver Broncos Reebok Throwback Vintage Pro Fit T Shirt / Napoline, Roman Rock, Design Genuine Leather Jacket, Black / Nautica Men's Scarf With Fringe / Gildan Men's Long Sleeve Fitted T-Shirt. 5400 / SockGuy Crew 8in Play Lacrosse White Socks / DeLux Wolf Face Wool Pilot Animal Cap/Hat with Ear Flaps
As it is once certain that absolutes are extracted finished a complex act in which various types of natural science solvent are used, conversely they are removed in the concluding phase of extraction. But sometimes, a diminutive magnitude of natural science solvent can be copied in the closing article of trade. Indeed, this is lone the snag of using absolutes in aromatherapy; as aromatherapy solely makes use of innate products. So, when absolutes are utilised in aromatherapy, they inevitability an uncompromising attention to detail.
Some of the having mass appeal absolutes are as follows:
o Jasmine.Post ads:
Yankees Mitchell & Ness MLB Back-Up Satin Jacket - Men's / Ralph Lauren Mens 2 Button Tan Brown Silk Wool Sport Coat / neff Men's Hustlin Tee / 32" Inseam Mossy Oak Piedmont Pants / Hudson Men's Byron Straight Leg Pant / Calvin Klein Sportswear Men's Short Sleeve Yarn Dye / TIFFANY SUNGLASSES TIF 3021 HAVANA 6002/3B TIF3021 / Reversible Camo Neon Orange Beanie / Callaway Golf Men's Long Sleeve V Neck Windshirt / Marmot Men's Hampton Insulated Jacket / Isotoner Men's Genuine Leather Gloves with Microluxe / Ecko Mens Denim Shorts - Style EKO_05601E / Marc New York by Andrew Marc Men's Paxton Pressed Wool / Quiksilver Waterman Men's Maldive 5 Walkshort / M-Clip Natural Solid Slide Ultralight V2 Anodized Money / Rip Curl Men's Classic Short Sleeve Wave Lycra Rash Guard / NRS HydroSkin Short
Jasmine fetch comely and breakable odor. It is previously owned in perfume products and in varied therapies. It helps in hardening assorted women tribulation such as illegal expelling cycles, headaches etc. It is medicinal drug and germicidal in nature. It is extracted by victimization solvents.
o Lotus
It is extracted from an assortment of albescent or pink lotuses through with solvents. It boosts up firmness and self astonishment. It is routinely used for curative a range of hitches.
o Rose
Rose direct is extracted from rosaceous flower, which variety use of solvents. It has a exceedingly exquisite and passionate property. It removes fatigue and gives a sensual awareness. It is too utilised in assorted ornamental products such as soaps, lotions, and creams etc. Rose unmixed is anti-viral and anti-bacterial in outlook.


text:
Willie Sheldon Photographer
Nadia IsabellaModel Female Iowa City, Iowa, US
Mayhem # 2624316
About MeI am an aspiring model. My dream is to move to a big city and work with known designers. I haven't quit desided what kind of modeling I want to do exactly. My interests are fashion, fitness, make-up, speaking, swim wear, etc. I used to be a big tom boy, then I grew up. My style is girly and chic.
Have you worked with Nadia Isabella? Add Credits for Nadia Isabella ! >>
Loading Content


text:
The Malik Report
Red Wings-Hurricanes quick take: ugly always counts for two points, and thanks, Petr
by George Malik on 10/10/15 at 09:42 PM ET
Comments (10)
Back-to-backs. The Red Wings have 16 sets of them this season, playing almost every Friday and Saturday until American Thanksgiving, and back-to-backs tend to test teams' character and resolve.
The Wings kicked off their back-to-back-heavy schedule with a 4-3 win over the Carolina Hurricanes on Saturday night, and the win was anything but pretty--save the goals the Wings scored and the saves Petr Mrazek made en route to a 44-save performance, anyway.
Detroit looked exhausted and was out-skated, out-worked and out-hustled for the vast majority of the game, and when the Wings finally went down by a goal, Jeff Blashill's decision to place Tomas Tatar, Teemu Pulkkinen and Dylan Larkin together = 2 goals in 1:57 and a hard-fought victory that was made possible by Justin Abdelkader's "insurance" goal.
Filed in: | The Malik Report | Permalink
Red Wings-Hurricanes game-day articles: Canes gear up for home opener; Wings bet on Mrazek
by George Malik on 10/10/15 at 12:54 PM ET
Comments (0)
Updated 5x at 1:55 PM: The Red Wings take on the Carolina Hurricanes tonight (7 PM on FSD/FS Carolinas/97.1 FM), and there were no surprises from the morning skate. Cam Ward will oppose Petr Mrazek, and CarolinaHurricanes.com's Michael Smith reports that the Canes will employ the following lineup...
Filed in: | The Malik Report | Permalink
Red Wings-Hurricanes morning skate Tweets: Canes start Ward vs. Mrazek; 'no changes' for Wings
by George Malik on 10/10/15 at 11:41 AM ET
Comments (1)
The Red Wings hope to build upon Friday's 4-0 win over Toronto when they take on the Carolina Hurricanes this evening (7 PM EDT on FSD/FS Carolinas/97.1 FM).
The Hurricanes took to the ice first, as CarolinaHurricanes.com's Michael Smith noted:
Morning skate time for the #Canes on #Canes101015. Home opener vs. Detroit coming up tonight.
#Canes forward lines:
E. Staal-Rask-Lindholm
Gerbe-J. Staal-Versteeg
Malone extra
#Canes defensive pairs:
Biega extra
The Raleigh News & Observer's Chip Alexander also reported from the Canes' skate:
Filed in: | The Malik Report | Permalink
A little more about Dylan Larkin's big night
by George Malik on 10/10/15 at 10:31 AM ET
Comments (1)
MLive's Brendan Savage offers this regarding Dylan Larkin:
He played for the United States in last season's World Junior Championship, was named the Big Ten Freshman of the Year as well as a second-team All-American for Michigan, made his pro debut in the AHL playoffs and helped Team USA win a bronze medal at the World Championship.
In six AHL playoff games, he had three goals and two assists for the Grand Rapid Griffins, whose coach at the time was none other than Blashill.
Blashill wasn't surprised by Larkin's coming-out party.
"I thought Dylan played very well," Blashill said. "I talked to him before the game. He's pretty unflappable. He seems to be extremely mature as a young guy. He seemed ready to go. I didn't think he pressed, didn't think he tried to do too much,
"I thought he played hockey and he does it very, very well. It was a good line. I didn't know how he was going to do on the wing. That was the one unknown for me, not that he's never played it. He played it a little bit for us in the Calder Cup playoffs but I thought that line was real effective. It's a good first step for him."
Filed in: | The Malik Report | Permalink
Videos- Game Highlights From Detroit's 4-0 Win Over Toronto
by Paul on 10/10/15 at 09:26 AM ET
Comments (5)
Two options today, first is from awood40...
Below, the game in six minutes with the Sportsnet feed...
Filed in: | The Malik Report | Permalink
Prospect news: Griffins lose in season-opener; Marsh scores for Saint John
by George Malik on 10/10/15 at 03:16 AM ET
Comments (1)
Of prospect-related note:
In the AHL, the Grand Rapids Griffins opened their 2015-16 season by playing the first AHL game in Bakersfield, California. While Tom McCollum stopped 39 shots and the Griffins nursed a 0-0 tie for over 58 minutes, the Griffins found themselves on the losing end of a 1-0 decision to the Bakersfield Condors thanks to a late goal from Andrew Miller and a would-be tying goal which the Bakersfield Californian's Mike Griffith reports was waved off:
Iiro Pakarinen broke down the right side and fired a shot at Tom McCollum from the circle. The rebound dropped in front of McCollum, and Miller was there to bang it past.
"Their goalie played phenomenal and so did ours," Miller said. "It was going to be a gritty goal, and luckily we were able to take the puck to the net and I was able to get the rebound."
The Griffins came storming back, with [Laurent] Brossoit making the first of his final three saves with 50 seconds left. Then came to the biggest save of the night as he somehow kept the puck out of the net with 31.4 ticks left.
There is video review in the American Hockey League, so fans had to wait, and wait and wait — it took about five minutes — before the referee finally ruled no goal.
"I knew 100 percent it wasn't in, but because it was such a long review I started doubting it." Brossoit said. "I asked the goal judge there and he said no and everyone else said no so after that I was pretty confident."
Here's the Grand Rapids Griffins' game report:
Filed in: | The Malik Report | Permalink
The overnight report: Red Wings-Hurricanes set-up
by George Malik on 10/10/15 at 02:41 AM ET
Comments (0)
The Detroit Red Wings hope to keep the good times rolling against the Carolina Hurricanes this evening (7 PM EDT on FSD/FS Carolinas/97.1 FM) despite having arrived in Raleigh at nearly 1:30 AM the morning after Friday's 4-0 Wings win over Toronto.
The Wings are playing an opponent for whom things can only get better: the Hurricanes dropped a 2-1 decision to the Nashville Predators on Thursday, and they lost James Wisniewski's services to a torn ACL along the way.
On Friday evening, the Raleigh News & Observer's Luke DeCock was attempting to accenetuate the positive from Carolina's Thursday effort, but he wasn't doing very well:
Filed in: | The Malik Report | Permalink
Red Wings-Maple Leafs wrap-up: Larkin, Abdelkader, and Blashill's first win, oh my!
by George Malik on 10/10/15 at 01:10 AM ET
Comments (7)
We might be getting a little ahead of ourselves when someone like Sportnset's Chris Johnston suggests the following...
Larkin could be a Calder candidate…All the talk surrounding Connor McDavid and Jack Eichel has been great for the NHL, but on the flipside it has overshadowed a handful of talented rookies, one of those being Dylan Larkin of the Detroit Red Wings. Larkin, the 15th-overall pick from 2014, had a goal and an assist in his NHL debut Friday as his Red Wings stomped all over the Maple Leafs. Larkin became the youngest Red Wing to score since Keith Primeau in 1991.
But this is pretty cool...
Filed in: | The Malik Report | Permalink
Quick take, Red Wings vs. Maple Leafs: Not bad for starters
by George Malik on 10/09/15 at 10:22 PM ET
Comments (22)
The angles, the lines, the incessant talk, mostly about the coaching staff, nearly five months of that ended when the puck was dropped at Joe Louis Arena this evening, and the Red Wings gave everyone something to talk about, defeating Toronto 4-0 on the strength of 3 Justin Abdelkader goals, one by Dylan Larkin and three assists by Henrik Zetterberg--and a shutout by James Tiberius Howard, all en route to a win that the Wings made look easy.
Not just that, but it was a 4-0 win where the Red Wings gave fans curly fries while trying very, very, very hard to not run up the score to half-a-dozen or more on a structure-less Maple Leafs team.
Filed in: | The Malik Report | Permalink
Here's Justin Abdelkader's hat trick
by George Malik on 10/09/15 at 10:04 PM ET
Comments (0)
He should keep wearing the $20 shield.
Filed in: | The Malik Report | Permalink
« Previous ‹ First < 538 539 540 541 542 > Last › Next »
About The Malik Report
The Malik Report is a destination for all things Red Wings-related. I offer biased, perhaps unprofessional-at-times and verbose coverage of my favorite team, their prospects and developmental affiliates. I've joined the Kukla's Korner family with five years of blogging under my belt, and I hope you'll find almost everything you need to follow your Red Wings at a place where all opinions are created equal and we're all friends, talking about hockey and the team we love to follow.
Most Recent Blog Posts
Sipple: Filip Larsson, Swedes prepare for World Junior Summer Showcase (now with more Rasmussen)
A brief note about Tomas Tatar's re-signing
Grand Rapids Griffins Sign Goaltender Pat Nagle
Wings' 'Final Farewell' to the Joe focuses on fans, last game at JLA
Morning news: Kotkansalo wears the 'C'; profiling David Pope, etc.
(Early) Morning news: On Dylan Larkin, the World Junior Summer Showcase and Jake Paterson's new team
Krupa's top 12 Wings prospects
A lengthy remembrance of Gordie Howe
Morning news: On a charitable endeavor, Jordan Sambrook, Walleye try-outs and Tweets of note
Wings' 'Final Farewell' to the Joe continues with alumni memories


text: Low on budget, low on plot (and low on porn stars . . . despite the title, it doesn't have any!), Amateur Porn Star Killer (2007) is pseudo-snuff for snuff's sake. The shot-on-DV brutality follows psycho Shane Ryan (also the film's director and co-scribe) as he drives around with his video camera looking for a victim. He finally picks a doozy: she's his co-writer, Michiko Jimenez! As young, doomed Stacy, Michiko does the cuckoo thing and trusts Shane to give her a ride; they end up at a dingy...Join Mr. Skin for the full review >>


text:
Product Spotlight
Featured Research
Quick Stats
You are here
Washington Safeway Stores Raise Almost $700k for Breast Cancer Research
PLEASANTON, Calif. -- Safeway Inc.'s Washington division raised $698,745 through fundraising campaigns held during Breast Cancer Awareness Month this past October.
PLEASANTON, Calif. -- Safeway Inc.'s Washington division raised $698,745 through fundraising campaigns held during Breast Cancer Awareness Month this past October.
Proceeds from the campaign will be contributed to University of Washington, Fred Hutchinson Cancer Research, Northwest Hospital Foundation, Cierra Sisters, St. Mary's Medical Center, Memorial Hospital, Wellness Place, and The Foundation Deaconess & Valley Healthcare.
Since 2001, Safeway's Seattle Division which covers a four-state region (Montana, Washington, Idaho & Alaska) has raised $2.9 million for breast cancer research efforts through its grassroots campaigns.
"Safeway has long held the position that it is our civic duty to take a proactive role in the fight against breast cancer," said Cherie Myers, director of public & government affairs for the company. "Our customers and employees of Washington have proven again that it is their generosity and passion toward this cause that is the greatest treasure of all. Without their support and belief in our ability to help bring about a cure, our impact would not be so profound. We look forward to the day when a cure is found for breast cancer that currently holds all women at risk."
Customers participated by donating spare change at the check stands, purchasing pink rubber-band bracelets and rings, and contributing to in-store special events. There were no administrative costs to run the campaign; contributions went directly toward breast cancer research.
In total, 195 stores within the Seattle Division participated in the month-long fund-raising campaign. Their combined efforts resulted in a collective contribution of $825,582 with the majority allocated to breast cancer research facilities and within the respective state of where the funds were raised.


text:
The Grove of Inari was the most sacred location in all of Fox lands. It is located within Kitsune Mori, and was the place where the kitsune spirits first approached the ancestors of the Fox Clan. [1] [2]
See Also Edit
- ↑ Way of the Minor Clans, p. 5
- ↑ Nightmares, by Ree Soesbee
|This Fox Clan related article is a stub. That means that it has been started, but is incomplete. You can help by adding to the information here.


text:
Nomenclature and placental mammal phylogeny
An issue arising from recent progress in establishing the placental mammal Tree of Life concerns the nomenclature of high-level clades. Fortunately, there are now several well-supported clades among extant mammals that require unambiguous, stable names. Although the International Code of Zoological Nomenclature does not apply above the Linnean rank of family, and while consensus on the adoption of competing systems of nomenclature does not yet exist, there is a clear, historical basis upon which to arbitrate among competing names for high-level mammalian clades. Here, we recommend application of the principles of priority and stability, as laid down by G.G. Simpson in 1945, to discriminate among proposed names for high-level taxa. We apply these principles to specific cases among placental mammals with broad relevance for taxonomy, and close with particular emphasis on the Afrotherian family Tenrecidae. We conclude that no matter how reconstructions of the Tree of Life change in years to come, systematists should apply new names reluctantly, deferring to those already published and maximizing consistency with existing nomenclature.
The last decade has witnessed an unprecedented increase in the stability of the mammalian Tree of Life [e.g.,
At the family level and below, Linnean categories require types (genera for families, species for genera, specimens for species). Hypotheses regarding phylogenetic dispersion around the type form the anchor points from which synonymies can spring. Because the ICZN does not apply to units of the Linnean hierarchy above the family, high-level nomenclature does not have at its core the type concept. This is a fundamental difference between low- and high-level taxonomy. Not only are high-level taxa not associated with type grounding, but they are also freed from requirements of diagnosis/description, a requirement at least in the vaguest sense for establishment/availability of lower-level names. In practice, it is a hypothesis of common ancestry that forms the basis of a high level name, and considerable judgment must be exercised, in addition to phylogenetic scrutiny, to decide how much this hypothesis can be modified before the name is sufficiently compromised to demand synonymy.
For the high-level clades within Mammalia, the best set of guiding principles for high-level taxonomy are the introductory pages of Simpson
A plethora of new names have been applied to high-level mammalian clades in recent years (summarized in Fig.
Figure 1
Summary of placental mammal taxonomy based on the phylogeny of
Summary of placental mammal taxonomy based on the phylogeny of
Table 1
Summary of mammalian taxonomic terms based on Fig. 1
Taxon with priority
All descendants of last common ancestor of sloth, tenrec, human, horse
Xenarthra, Afrotheria
Paenungulata, Afroinsectiphilia
Tubulidentata, Afroinsectivora
Fossoromorpha [
Tenrecoidea, Macroscelididae
Tenrecidae, Chrysochloridae
Hyracoidea, Tethytheria
Proboscidea, Sirenia
Boreoeutheria [
Laurasiatheria, Euarchontoglires
Lipotyphla, Scrotifera
Ferae, Chiroptera, Euungulata
Variamana [
Artiodactyla, Perissodactyla
Artiodactyla [
Whippomorpha, Ruminantia, Tylopoda, Suiformes
Carnivora, Pholidota
Cetacea, Hippopotamidae
Erinaceidae, Talpidae, Soricidae, Solenodontidae
Archonta, Glires
Lagomorpha, Rodentia
Primates, Scandentia, Dermoptera
Scandentia, Dermoptera
Author attributions are based on the first use of the clade with its current, or near-current, meaning. For example, Butler
Table 2
Taxonomic designations for named clades with potential support [e.g.,
Taxon with priority
All placental mammals except Afrotheria
All placental mammals except Xenarthra
Carnivora, Perissodactyla, Artiodactyla
Here, we suggest how an application of Simpson's guidelines can help discriminate among competing names for high-level groups of placental mammals. In a nutshell, priority and stability should comprise the overriding principles by which new, high-level taxa are named. Established names for any given clade should not be altered unless the name with precedent unambiguously threatens stability. We suggest that the most appropriate will be those that are 1) the first, published name for a monophyletic group with unique content and 2) based on terms deemed familiar and logical to as many students as possible. Failure of a given taxon to meet one of these criteria does not necessarily mean it is invalid, but failure in both should.
Names for a resolved tree
Arnason et al.
Balancing priority and stability
While Arnason et al.
In the same way that we are compelled to accept Ameghino's references to primates and equids among names for unrelated, endemic South American mammals, supraordinal taxa similarly deserve recognition based in the first instance on priority, even if this involves questionable orthography and/or etymology. Hence, genuinely novel clades should be known by their earliest published names. For mammals, this includes Laurasiatheria, Boreoeutheria, Afrotheria, Atlantogenata, Scrotifera, and Euarchontoglires (Fig.
Several mammalian clades have a long history among taxonomists, and have been recognized as such in most recent studies. These include Paenungulata, Glires, Archonta, and most individual orders within Mammalia
As discussed above, Archonta is preferable to "Euarchonta"
Arguably, therefore, Waddell's concept would be preferable here too. Favoring Euungulata Waddell et al. 1999
Cetaceans and artiodactyls
The first published name for the hippo-whale clade was Whippomorpha Waddell et al. 1999
The name for the larger assemblage of terrestrial artiodactyls plus Cetacea nested within it is slightly more problematic. As previously stated, stability would be served by retaining the name Artiodactyla over its frequently used alternative, "Cetartiodactyla", despite the addition of cetaceans. While addition of the "cet" prefix has become very popular in the mammalian systematics literature, Artiodactyla as a published ordinal designation is still widespread, with over 15000 hits on google scholar from 2000-2009, vs. 482 for "Cetartiodactyla". The advantages of formalizing the new and very well supported systematic position of whales in its high-level taxonomic designation are considerable. Furthermore, given the fact that in some morphological aspects (dentition, body size) whales are more varied than even-toed ungulates classically arranged within Artiodactyla, a name change may be warranted under Simpson's criterion for "reasonable emendation" (
Eparctocyona was used by McKenna
Tenrecids and chrysochlorids
Both Zalambdodonta Gill 1883
In any event, "Afrosoricida" is a name with misleading taxonomic implications, implying a family group association with
To make matters more complicated, a few authors
Such a proposal for nomenclature within the extant Afroinsectivora is shown in Fig.
Figure 2
Proposed taxonomy for afroinsectivoran mammals, maintaining common understanding of Tenrecidae
Proposed taxonomy for afroinsectivoran mammals, maintaining common understanding of Tenrecidae
Linnean rank and priority
Linnean ranks were important to Simpson
For these reasons, i.e., the same ones that compel use of Ameghino's generic or Waddell's supraordinal names (due to priority), Gregory's Archonta or Owen's Dinosauria (despite changes within each taxon), we regard Afrosoricida Stanhope et al. 1998
Systematists now have an unprecedented understanding of how clades of mammals are interrelated. Arguments about nomenclature are a side-effect of this positive state of affairs, a welcome change from the days, not so long ago, when decades of study did not lead to broad consensus on the affinities of certain high-level clades
Authors' contributions
RA conceived of the study and wrote the first draft; KH made substantial corrections and additions to the text. Both authors read and approved the manuscript.
We thank Rainer Hutterer and Eric Sargis for discussion.
Resolution of the early placental mammal radiation using Bayesian phylogenetics
Confirming the phylogeny of mammals by use of large comparative sequence data sets
Using genomic data to unravel the root of the placental mammal phylogeny
A web-database of mammalian morphology and a reanalysis of placental phylogeny
The new framework for understanding placental mammal evolution
International Code of Zoological Nomenclature
A Guide to Constructing and Understanding Synonymies for Mammalian Species
The principles of classification and a classification of mammals
Classification of mammals above the species level
PhyloCode: A Phylogenetic Code of Biological Nomenclature, Version 2a
PhyloCode: Pain, No Gain
The Illogical Basis of Phylogenetic Nomenclature
Are the Linnean and Phylogenetic Nomenclatural Systems Combinable? Recommendations for Biological Nomenclature
Critique of pure folly
The PhyloCode is fatally flawed, and the "Linnaean" system can easily be fixed
Mitogenomic relationships of placental mammals and molecular estimates of their divergences
Towards resolving the interordinal relationships of placental mammals
The mitochondrial genome of the sperm whale and a new molecular reference for estimating eutherian divergence dates
Molecular evidence for multiple origins of Insectivora and for a new order of endemic African insectivore mammals
Cretaceous eutherians and Laurasian origin for placental mammals near the K/T boundary
The Orders of Mammals
Toward a phylogeny and classification of the Mammalia
Timing and biogeography of the eutherian radiation: Fossils and molecules compared
Major mammalian clades: a review under consideration of molecular & palaeontological evidence
Notices préliminaires sur les ongulés nouveaux des terrains crétacés de Patagonie
Mammifères crétacés de l'Argentine
The Greater Antillean insectivores
On the classification of the insectivorous mammals
Pegasoferae, an unexpected mammalian clade revealed by tracking ancient retroposon insertions
Molecular and genomic data identify the closest living relative of primates
A phylogenetic foundation for comparative mammalian genomics
Intraordinal phylogenetics of treeshrews (Mammalia: Scandentia) based on evidence from the mitochondrial 12S rRNA gene
A molecular classification for the living orders of placental mammals and the phylogenetic classification of primates
Phylogenetic systematics of the Primatomorpha, with special reference to Dermoptera
Phylogenetic relationships of artiodactyls and cetaceans as deduced from the comparison of cytochrome b and 12S rRNA mitochondrial sequences
Molecular evidence for the inclusion of cetaceans within the order Artiodactyla
Cytochrome b gene of marine mammals: Phylogeny and evolution
Evidence from milk casein genes that cetaceans are close relatives of hippopotamid artiodactyls
Higher taxonomic relationships among extant mammals based on morphology, with selected comparisons of results from molecular data
Preface: from basic uniformity to diversity in cortical organization
Characterization of an endogenous retrovirus class in elephants and their relatives
Locking yourself out: zalambdodonty as a key adaptation
Morphology and relationships of Apternodus and other extinct, zalambdodont, placental mammals
Phylogenetic Relationships of Hedgehogs and Gymnures (Mammalia, Insectivora, Erinaceidae)
A new classification of mammals
Phylogenetic position of the Tenrecs (Mammalia: Tenrecidae) of Madagascar based on analysis of the complete mitochondrial genome sequence of Echinops telfairi
Mammalian mitogenomic relationships and the root of the eutherian tree
Evaluating placental inter-ordinal phylogenies with novel sequences including RAG1, gamma-fibrinogen, ND6, and mt-tRNA, plus MCMC-driven nucleotide, amino acid, and codon models
Insectivoran grade placental mammals: character evolution and fossil history
A New Genus of Shrew from Central-Africa (Mammalia, Soricidae)
Order Insectivora
Molecular support for Afrotheria and the polyphyly of Lipotyphla based on analyses of the growth hormone receptor gene
Womb with a view: the rise of placentals
Phylogeny and life histories of the 'Insectivora': controversies and consequences
Evolutionary transformations of fetal membrane characters in Eutheria with special reference to Afrotheria
A revised systematic checklist of the extant mammals of the southern African subregion
"Lipotyphlan" phylogeny based on the growth hormone receptor gene: a reanalysis
Order Afrosoricida
New remains of Eocene and Oligocene Afrosoricida (Afrotheria) from Egypt, with implications for the origin(s) of afrosoricid zalambdodonty
Evolutionary morphology of the Tenrecoidea (Mammalia) hindlimb skeleton
Phylogeny, behavior, and ecology in the mammalia: lessons from the Tenrecidae
Phylogeny and biogeography of tenrecs
Tenrec phylogeny and the noninvasive extraction of nuclear DNA
Molecular phylogeny and divergence times of Malagasy tenrecs: influence of data partitioning and taxon sampling on dating analyses
On the structure of the skull in
Walkers' mammals of the world 6th edition
The Human Story: Where We Come From & How We Evolved
A monograph of
Morphology, Adaptations, and Relationships of Plesiorycteropus, and a Diagnosis of a New Order of Eutherian Mammals
A new systematic arrangement of the vertebrated animals
Molecular evidence for major placental clades
Phylogenetics. Which mammalian supertree to bark up?
Description of teeth and portions of jaws of two extinct anthracotherioid quadrupeds ... discovered ... in the Eocene deposits on the NW coast of the Isle of Wight
A new phylogenetic marker, apolipoprotein B, provides compelling evidence for eutherian relationships
Generelle Morphologie der Organismen: allgemeine Grundzüge der organischen Formen-Wissenschaft, mechanisch begründet durch die von Charles Darwin reformirte Descendenz-Theorie
Systema naturae: Regnum animale. a photographic facsimile of the first volume of the tenth edition
The problem of insectivore classification
Mammalian mitogenomic relationships and the root of the eutherian tree


text:
You just click Store Categories > Then click the link for the 'Bathroom' main category > Then add all your sub categories within Bathroom (Towels, hand soap, etc). Then click Save.
If you wished to create subcategories within subcategories, then just click the Towels link (for example) and create those subcategories.
Discover four of the most profitable niches on eBay and get details for the best suppliers for these niches. Enter your details below and we will send them instantly.
Your list of profitable markets and supplier details are on their way to your email inbox.
Be sure to add email@example.com to your safelist to ensure we can deliver the free suppliers details to you.
If you haven't received an email from us in 5 minutes, please check your spam folder or email us at email@example.com.


text:
(The Hosting News) – In what could be considered the most high profile security breach within the hosting industry in some time, top domain registrar GoDaddy.com and its hosted sites faced extended downtime mid-Monday.
The cause? An apparent online attack made by a supporter of notorious hacking group Anonymous appearing under the Twitter name "Anonymous Own3r."
The web host's site remained inaccessible for part of the day, and according to an Associated Press report, hosted sites facing problems may have numbered anywhere between thousands to millions.
"Status Alert: Hey, all. We're aware of the trouble people are having with our site. We're working on it," stated Go Daddy via its Twitter feed. Meanwhile, a later post indicated that the company was "getting closer to normal" and the web host thanked its clientele for their "patience and understanding."
While speculation of the attack's origin was concentrated on Anonymous, the person taking credit for it emphasized it was a one-person operation. "tell the people to not understand wrong the attack is coming only from me," tweeted Anonymous Own3r.
Anonymous is one of the world's most well known hacking group. It's unclear what kind of tactic was used in the attack, whether it be DDoS or a data breach. More details to follow..