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Anakeesta Ridge Then spent an hour or two scooting and sliding down and across the scar and into the creekbed and debris field (a huge, nasty tangle of trees). The ridge up was full of briers and blowdowns. My arms look like a lost a fight with a wampus cat. The slide down was almost too steep, but not quite. Which means it was just right. Wore a couple of holes in the seat of my pants, plus more cuts and bruises on my hands. All the makings of a great day. (If you don't mind briers, snakes, yellow jackets, cuts and bruises, blood, blown-down trees.) Comment by Greg Hoover on April 18, 2011 at 9:45am I giggled for five minutes about the "laundry bag" comment. My first attempt to Anakeesta Ridge was from the Boulevard. It was nasty and uneventful. We found the unnamed ridge that is now our standard route up by accident. Missed the "turn" to continue along the main ridge and found ourselves on this side ridge -- we could hear traffic not far below us and decided to abort the mission by backtracking but to try the side ridge sometime. This side ridge is much more interesting and quicker than the AT and Boulevard route. I haven't burned any clothes but I have thrown some away. Burning does have a nice sense of ceremony and finality. did you make the climb with a sack of laundry on your back, like Brian? It really is mostly a sack of laundry. I like to tie jackets and coats on the outside of my pack rather than stuff them inside. Makes it look twice as big as it really is. I don't know Jenny, all this talk of blood and suffering doesn't seem like much of an advertisement to me. I can add I had to throw some of my clothes out afterward. Actually it is a worthwhile place to visit, but you should only go with somebody like Greg unless you do this kind of thing regularly. Comment by Dan G on April 15, 2011 at 6:05pm Up on Anakeesta Ridge, you can really see how slide mechanics work. In many places mazes of roots are elevated off the ground since the soil beneath has been eroded away by cloudbursts. As a buddy of mine put it, you have rocks held in place by nothing but roots roots after the surrounding soil has washed away, and before long gravity takes over and here comes another rockslide. For those wondering about heading over to Anakeesta Knob/The Boulevard and back, I'm told it's a good 8 hour round trip complete with ten kinds of ugly and spruce thickets. If one simply must do it, it's doable, but you will bleed! Comment by Greg Hoover on April 15, 2011 at 11:28am There a lots of annoying spots but nothing truly, deeply dangerous. There are places where a guy could die, but they are easy to see and avoid. The best thing is that it's not as dangerous as it looks -- which it perfect. You can impress your friends by showing them the landslide scar (of post a picture on a blog!) and they are seriously impressed. But it's not as life-threatening as it looks. But, yes, my arms and legs are seriously scratched. By the way, a friend and I first did this trip a couple of years ago, and we were conversing about how we were in the middle of nowhere, and that we must be the only ones who had been up here in years, maybe ever, Just us brave, macho guys and the bears. Then we looked down at the rock we were standing on. A cigarette butt. Burst our macho, tough guy bubble.


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Cyclacel Pharmaceuticals, Inc. (NASDAQ:CYCC)
Q4 2013 Results Earnings Conference Call
March 25, 2014 4:30 PM ET
Bill Harris - Corporate Controller
Spiro Rombotis - President and CEO
Paul McBarron - Executive Vice President, Finance and COO
Dr. Judy Chiao - Vice President of Clinical Development and Regulatory Affairs.
Mike King - JMP Securities
Kim Lee - Janney Capital
Ed White - Laidlaw & Company
Good afternoon and welcome to Cyclacel Pharmaceuticals' Fourth Quarter and Full Year 2013 Earnings Conference Call and Webcast. Today's call is being recorded. At this time, all participants have been placed in a listen-only mode and the floor will be opened for your questions following the presentation. (Operator Instructions)
It is now my pleasure to turn the floor over to Bill Harris, Cyclacel's Corporate Controller. Sir, you may begin.
Bill Harris
Thank you. Good afternoon and welcome to our quarterly conference call. During today's call, members of our senior management team will review Cyclacel's financial performance and business highlights for the fourth quarter and full-year ended December 31, 2013.
Before turning the call over to senior management, I would like to remind everyone that during this conference call, any forward-looking statements made by the company are intended to fall within the Safe Harbor provisions of the Private Securities Litigation Reform Act of 1995 and Section 21E of the Securities Exchange Act of 1934 as amended.
As set forth in our press release, forward-looking statements involve risks and uncertainties that may affect the company's business and prospects, including those discussed in our filings with the SEC, which include, among other things, our Form 10-K. These filings are available from the SEC or our website. All of our projections and other forward-looking statements represent our judgment as of today and Cyclacel does not take any responsibility to update such information.
With us today are Spiro Rombotis, President and Chief Executive Officer; Paul McBarron, Executive Vice President, Finance and Chief Operating Officer; and Dr. Judy Chiao, Vice President of Clinical Development and Regulatory Affairs.
At this time, I would like to turn the call over to Spiro Rombotis, our President and CEO.
Spiro Rombotis
Thank you, Bill and good afternoon. During 2013, we continued to progress clinical development of sapacitabine in patients with acute myeloid leukemia or AML and myelodysplastic syndromes or MDS and solid tumors.
On today's call, we will update you on the progress of SEAMLESS, our Phase 3 registration study of sapacitabine in its lead indication as a frontline treatment for elderly patients with AML. We will also provide certain information that underlines our planning for the second indication of sapacitabine as a treatment for older patients with MDS after failure of hypomethylating agents or HMAs.
Finally, we will recap key events of the fourth quarter of 2013 and discuss our financial position. First, we will comment on our SEAMLESS study in AML which has been conducted under a Special Protocol Assessment agreement with the U.S. FDA.
As you will recall, SEAMLESS is comparing sapacitabine and decitabine administered in alternating cycles versus decitabine alone as controlled and we enrolled approximately 485 patients. The primary endpoint is overall survival. As decitabine was not until recently commercially available in Europe, we have been enrolling just in the U.S.
As reported previously, enrollment of 39 American sites have been strong. We are currently approaching 60% and the fourth periodic safety review for the studies, independent Data Safety Monitoring Board or DSMB. Safety reviews are conducted every 100 patients with 60 days of follow-up. In all previous reviews, the DSMB found no safety or efficacy concerns and recommended that the study should continue as planned.
As indicated in today's press release, we plan to treble the number of clinical centers participating in SEAMLESS and are pleased to report today initiation of our first European study sites. Following the recent European launch of decitabine which enables European investigators to participate in the SEAMLESS study, we conducted a feasibility assessment in which more than 100 European hospitals expressed interest in participating. After completing qualification, we expect to select and initiate approximately 80 of these sites.
This will accelerate the accrual pace of SEAMLESS as the total number of sites will triple to approximately 120 including existing U.S. sites. Based on the European expansion, we estimate completion of enrollment for SEAMLESS by the end of this year in top line data next year.
To recap, we expect free milestones for the SEAMLESS study in 2014, DSMB safety review of approximately 300 patients after 60 days of follow-up, DSMB futility analysis after 212 events or deaths and completion of enrollment.
Now let us turn to MDS. Following Phase 2 data reported at ASH 2013 demonstrating a near doubling of expected median survival of older patient with MDS after treatment failure of hypomethylating agents or HMAs, we are evaluating a randomized controlled trial or RCT of sapacitabine in this underserved patient population. We plan to disclose our plans for this second indication of sapacitabine later this year after obtaining inputs from U.S. and European clinical, regulatory and sophistical experts and the evaluation of feasibility.
For instance, we will have an opportunity to discuss our MDS plans at an upcoming European investigator meeting. Most of the European centers, we are now opening to accelerate SEAMLESS enrollment to also treat MDS patients. In addition, certain of these investigators have participated in pivotal studies with HMAs as front-line therapies for MDS.
We expect that the U.S. and EU clinical trial network of SEAMLESS would also run an RCT in MDS. We appreciate that there is a lot of investor and pharmaceutical company interest regarding our plans in high-risk MDS after HMA failure. In this respect, we would like to share with you certain aspects of our thinking regarding this indication.
There are several challenges and opportunities that need to be carefully considered before designing an RCT to increase the chance of a successful outcome. MDS is a form of blood cancer in which the bone marrow malfunctions. Scientifically, MDS is a clonal disease of ineffective hematopoiesis with cytopenias in peripheral blood and risk of progressing or transforming into AML.
Patients with high-risk MDS are treated with an HMA drug as front line. Typically, this is azacitidine, less frequently, it may be decitabine. In accordance with the azacitidine label, only 6% of patients achieve complete remission or CR from azacitidine, suggesting that CR is a poor surrogate endpoint for evaluating survival.
Depending on whether they respond or not to HMAs, nearly old patients eventually relapse or experience disease progressions despite HMA therapy. In healthy people, all patients responding to front-line therapy, the normal state for complete remission respectively is defined as immune cells, white blood cells or platelets at normal levels and blasts or cancer cells amounting to 5% or less of the bone marrow.
The World Health Organizations or WHO's definition of MDS is blasts or cancer cells amounting to between 6% and 19% of the bone marrow. Blasts at or above 20% is defined as the boundary of leukemia or AML. In all the classification called the FAB or French-American-British System demarcated leukemia or AML as blasts at or above 30%. For this historical reason, the azacitidine label as front-line therapy for high-risk MDS is for blasts below 30%.
Now within these boundaries of MDS defined by blast level, it is desirable to further distinguish between two subgroups, low blast or 6% to 9% and high blasts or 10% to 19% at WHO or 10% to 30% for FAB. Different treatment strategies maybe beneficial for each of these two different subgroups.
Low blast patients typically have low blood counts. In other words, they have a low level of cancer cells but also low level of immunity. And aggressive myeloablative strategy may not be desirable for these patients. There are too few cancer cells to kill and the myeloablative treatment may result in increased infection by further worsening dangerously low levels of blood counts.
These patients are generally offered supportive care and the median survival tends to be around eight months. High-blast patients may have faster disease progression and the risk of transforming into AML and leukemia with median survival of three and half months if left untreated.
There is no effective therapy for high-blast patients after HMA failure. Median survival for high-blast patients is around five months, which is considerably shorter than low-blast patient. Based on the sapacitabine data reported at ASH, Cyclacel is considering an RCT to evaluate sapacitabine in high-risk MDS patients after HMA failures. The primary endpoint will be overall survival.
Our current population will be patients with high blasts of 10% or higher. As a reminder, in our ASH data reported three months ago, approximately two-thirds of the population have high blasts of 10% or higher. Their median survival at 9.7 months was comparable with the intent-to-treat population.
Please note that this median overall survival was measured on the time of registration in our study. It did not capture any additional time elapsed between withdrawal of the HMA front-line drug and registration of the sapacitabine study.
We will supply additional details with regard to our MDS study after completing consultations with experts and feasibility surveys. If the outcome of the MDS randomized study meets or exceed expectations, we intend to discuss the data with regulatory authorities.
Before I hand over to Paul, let me recap our three key highlights of the fourth quarter. The DSMB for SEAMLESS completed its third planned safety review of 212 patients, identified no safety or efficacy concerns and recommended that the study continue its plan without modification. The next plant safety review is forth coming.
As discussed earlier in the call, at ASH, we reported Phase 2 survival data of sapacitabine in high-risk MDS patients after HMA failures. We were awarded two U.S. patents covering sapacitabine use with HMAs and sapacitabine dosing regimens including that used in SEAMLESS. The patents extend market exclusivity of sapacitabine out to 2013.
I will now turn the call over to Paul.
Paul McBarron
Thank you, Spiro. Our cash position was $31.1 million at year end 2013 compared to $16.4 million at year end 2012. The increase is due to gross proceeds from our underwritten offering in May of $20.5 million, net proceeds of $8.9 million from the sales of common stock through our equity line and additionally $5.5 million from the sale to Celgene Corporation of romidepsin-related patents, a non-core program, offset by $18.2 million used in operating activities.
Revenue from the three months and year ended December 31, 2013 was $0.3 million and $1 million as compared to minimal revenue in the same period of 2012. The revenue is a grant award from the U.K. government, totaling $1.9 million to progress CYC065, our Cyclin Dependent Kinase or CDK inhibitor to the IND filing stage.
Research and development expenses increased to $2.5 million and $11.3 million respectively for the three months and year ended December 31, 2013 as compared to $2 million and $6.6 million for the same period of the previous year. The increases in 2013 were primarily due to enrollment activities of our SEAMLESS registration study, including drug manufacturing and other outsourced services.
General and administrative expenses for the three months and year ended December 31, 2013 were $1.8 million and $7.8 million as compared to $2.7 million and $8.6 million for the previous year. The decreases in 2013 were primarily due to lower legal and professional fees.
The research and development tax credit, which is cash we elect to receive annually from the U.K. tax authorities is $1.6 million for the year ended December 31, 2013, compared to $1.4 million for 2012. Although, we continued to focus the lion share of our resources from our Phase 3 AML program, we are selectively progressing other indications for sapacitabine and also our other drugs through investigated sponsored studies such as our seliciclib, CDK inhibitor in rheumatoid arthritis and non-diluted government grants such as our CYC065, CDK inhibitor and CYC140, a Polo-Like Kinase inhibitor in non-clinical programs.
To summarize, we have adequate capital to enroll the SEAMLESS Phase 3 study and to take us a few quarters beyond the projected data readout next year on SEAMLESS. Spiro?
Spiro Rombotis
Thank you, Paul. Operator, we are now ready to take questions.
Question-and-Answer Session
(Operator Instructions) Our first question comes from the line of Mike King with JMP Securities.
Mike King - JMP Securities
Hi, guys. Can you hear me?
Spiro Rombotis
We can hear you, Mike.
Mike King - JMP Securities
Hi. Thanks for taking the question. Just a couple of things that I wanted to ask you to talk about, one is maybe just talk a little bit about the whatever hurdles or the next steps with regard to actually enrolling patients in the European sites that was dependent upon the usual IRB stuff or whatever maybe required to actually enroll patients? Second is similar question about MDS, which is what are the gating factors or items are there before you can actually begin that protocol?
Spiro Rombotis
Let me take the first part of your question, which relates to the AML SEAMLESS study in Europe and then I will ask Judy to answer the second question which is the MDS program we discussed earlier. So the extremely good news is, we said in our prepared remarks is that we have now been through all Ethics Committee's reviews.
We have received competent authority approval in more than a dozen countries and we've just, as I mentioned been opening our first sites. So we are now open for a moment in Europe, Mike. We don't have anymore Ethics Committee IRB like processes to go through because that is open for enrollment.
Mike King - JMP Securities
Okay. So will you actually let us know when you've got patients in the study or can you say now that you have patients in the study in Europe?
Spiro Rombotis
Like I said, we have opened the sites. We will give an update during the next call when we'll have precise numbers. But we expect the dramatic acceleration of the patient enrollment as well as the slope of the enrollment. In other words, we expect to have the majority of the sites coming on stream, probably within the next few weeks of Q1 and most of Q2.
Mike King - JMP Securities
Okay. Great. Thanks for adding that clarity.
Spiro Rombotis
Judy wants to take next question about what that both analysis we are undergoing to design an MDS study?
Dr. Judy Chiao
Mike, the type of consultation I would say is with variety of experts and the purpose of the consultation is to understand that drug approval of patient populations was the unmet medical needs with all the standard and available therapies including clinical files with such patients and what type of benefits essentially, improvement of survivals that is clinically relevant and justifiable and how many patients are there that could be approved such as studying in a certain period of time. And I think, once we have those informations then we could understand beyond the patient populations what type of designs, what are the control arms and the sample size and the benefits which I will think would be improving over survival is reasonable and clinically significant.
Mike King - JMP Securities
Okay. Thank you for those answers. I just wanted also to, have you opined if you would, Spiro and perhaps Judy can join in as well. But we've recently seen some readouts of other studies in the MDS space in particular, the recent negative trial on the part of Onconova, at least to the overall patient populations and what lessons might be learned there from your standpoint either as regards control arm overall survival expectations and/or the possibility of exploring targeted patient subgroups?
Spiro Rombotis
Mike, as you know, our policy for many-many years at Cyclacel, we do not comment about colleagues or competitor's working in the same disease landscape. But looking that said in broad remarks about MDS, we also mentioned during our prepared section of remarks earlier this afternoon. I think it is important to understand the drug's properties before one proposes to benefit either the whole population or one of the subgroups. As I mentioned before, a drug which has no myeloablative profile may be understandably directed by physicians to patients that have a low blood counts because these patients will be more likely to perhaps not be in an inferior position if they were to receive a drug one by definition that blast at low level.
The drug like sapacitabine, however, which is myeloablative may be best positioned. They have the maximum benefit in patients with blast arising who are risk-averse forming into leukemia and this means that we may not be terribly informed as your question put it or learn lessons necessarily by drawing upon very different mechanisms and very different affects on cancer cells.
I supposed that one could look at the control on outcomes of other studies in MDS and feel reasonably confident that within a few weeks, these numbers are similar to those numbers published in recent literature citations. We're of the view that these numbers are averages and as a result, it is dangerous to use them as hard comparative benchmarks as they are very likely to be a medley, an average on a weighted basis for patients with high blasts as we know have lower survival than the patients with low blasts.
So until such studies either get published in a peer review setting but we see them in ASCO for example in a few weeks, it's going to be hard to make and form judgments as a way there are new lessons to be learned. We believe that for sapacitabine, our Phase 2 data reported in New Orleans last December during the ASH Conference speak very loudly. The drug affect is there for all patients but the numbers in terms of survival hold up also in the high blast subgroup. And that's the reason we announced earlier today that we believe this is the best population to study sapacitabine. I'll just give you some context of our thinking and how we looked at other company's data and how that may or may not influence our plans.
Mike King - JMP Securities
Great. That's helpful. Thanks.
Spiro Rombotis
Thank you.
Our next question comes from the line of Kim Lee with Janney Capital.
Kim Lee - Janney Capital
Good afternoon. Can you hear me?
Spiro Rombotis
We can hear you, Kim. Good afternoon.
Kim Lee - Janney Capital
Great. Thanks. Just a quick question on, what are your thoughts on obtaining an SPA for the NVS study, would it makes sense for you to do trials and do you have plans of having those discussions with the FDA?
Spiro Rombotis
Okay. Well, we have a great pleasure of having a former FDA regulator in our midst, which of course is the Dr. Judy Chiao who many of you now actually serve the U.S. FDA reviewing and regulating oncology drugs. So let me ask her to give us a quick survey of what is the value of the spot and why the company seek one and then we can make a couple of remarks regarding whether this is applicable in the case of our MDS program. Judy?
Dr. Judy Chiao
Thank you, Spiro. The Special Protocol Assessment process, I think is a very good program. But in general, that I would think that one needs to go to the agency with sometimes challenging questions and we did that for our SEAMLESS study. As you know that, a particular challenging question for the SEAMLESS trial is the control of decitabine.
And the second thing of course, if you have a controversial end point, primary end point of the study that will warrant a discussions. So, I think that from the MDS program, it depends really on what kind of control arms, whether that will cause any controversial that will warrant such a discussion with agencies then I think, that would determine whether if one should pursue this spots.
Regarding the primary endpoint, I don't think there is going to be too much debate on what the right endpoint should be in such a study. I personally would favor [over] survival because that to most of the patients, that's probably the most meaningful endpoint that to assess the clinical relevance. I do not think that there is any debate on choosing such an endpoint from the regulatory point of view, so that is not something I will view as controversial.
Spiro Rombotis
Thank you, Judy. Perhaps Kim, one more point to add is that there are some important differences between AML and MDS with regard to your well placed question about the need for a SPA. AML disease, but we haven't had any of the drug reach the market for more than 45 years. They are off-label use of approved drugs for other indications in AML. And that creates the controversy that Judy explained where it is probably useful for a sponsor to spend the six months of effort to get a SPA with the agency, so that the goalpost do not get moved.
Or at least, one has the comfort to know that despite in that case of AML, the decitabine control remaining off the market for the AML indication, that we have a SPA saying that the agency has agreed after their failure of decitabine to beat control in Phase 3 trial to allow us to use that as our control in the AML study.
Now MDS is a new disease. There is no 45-year old history. In fact, up until a decade or even less, maybe five years ago before HMAs became available, we didn't even know how many patients had MDS. The implications of that is that in the new indications, where benchmarks are not hard and fast, there is a paucity of published source literature, obtaining a SPA in the absence of a controversy may limit once options to argue for clinical benefit in the way as a new disease.
So for these reasons, we view that what happened in the AML does not predict what may happen in MDS. But as we said earlier, until we get our study design finalized for our consultations, we're not going to give a little more color. But I think I've given you at least the sense of where the value of the SPA is clear and where perhaps the expenditure of six months maybe less unclear.
Kim Lee - Janney Capital
Yes. It does. Great. Thank you for that clarity.
Spiro Rombotis
Thank you.
(Operator Instructions) Our next question comes from the line of Ed White with Laidlaw & Company.
Ed White - Laidlaw & Company
Hi. Good evening, everyone.
Spiro Rombotis
Good evening, Ed.
Ed White - Laidlaw & Company
So just a few timing questions for you, you had said that the time is approaching for the next DSMB review. Is that going to be measured in weeks or months and also that the time to the futility data?
Spiro Rombotis
Thank you, Ed. I think we can answer the first one with a bit more confidence because it is a question of patients and a 60-day follow-up clock and is probably weeks. In other words, we expect to cross the required threshold very shortly. The futility analysis is based on events, which in this trial given the primary endpoint of survival is deaths. And it is a bit difficult to project deaths although we feel it is going to be very likely a late 2014 events, probably in the second half of this year as our current estimate. Based on our current level of events, which we know and the fact that now that we have opened our first European sites, we expect a large influx of patients which will certainly cluster the events in the second half of the year.
You have to recall that the observation period for the study is around six to seven months. So if you're opening studies -- centers, excuse me, in the first quarter and throughout the second quarter, it's clear that that six to seven-month window will be fulfilled by the end of the year. So we think this is probably the right timeframe to project. As we get a bit closer probably our next earnings call, we will give a bit more guidance but that is our current guestimate.
Ed White - Laidlaw & Company
Okay. Great, thank you. And so on SEAMLESS, you continue to say that you expect to be fully enrolled by year end, top-line data though you are just saying next year, could you be a little bit more specific on that, may be early, late or a quarter?
Spiro Rombotis
We cannot give quarter granularities. It's too early given the fact that we have a mid-stream trebling over the number of centers. We just don't know what the slope of the normal curve will be in a precise way. We do know as when they dramatically increase that is in the steeper holdings, we're our trebling the number of sites. We know that as I said that the observation period when the required number of patients enrolled is driven by the required number of events which is around 424.
We expect that this will happen towards the end of this year i.e. enrollment and then within the six to seven months that follow the last patient in, we should have much of the data granulized. So we think that middle of the next year is a reasonable guestimate but again we will provide more granularity as in the next and following quarters, we will give more precise information on the factual basis of the enrollment slope in particular because of the European expansion.
Ed White - Laidlaw & Company
Okay, great. Thank you. And my last question, I just want to address the MDS study, do you expect to start the MDS study before fully enrolling SEAMLESS and then also do you think you will need two Phase 3 studies in MDS?
Spiro Rombotis
I will take the first question. Judy, who is the firm regulator will take the second question. I think you are raising an excellent point. Are we ready to begin MDS before SEAMLESS completes enrollment, the answer is yes. However, there may be a reason to make us a bit more cautious and that is that if a patient who drops off the AML study, SEAMLESS and has been randomized to the control arm which is decitabine, may possibly be eligible for enrollment in an MDS study.
Remember they have failed in HMA. So if the exposure of this patient for sapacitabine in the second trial which is the MDS, makes them little longer that clearly is adverse to our purpose in SEAMLESS. So there are some complications that we need to carefully think about but for all types of purposes we will be ready in 2014 to begin, assuming that SEAMLESS enrollment goes as expected. Judy, would you like to take the second question.
Dr. Judy Chiao
Yes. Thank you, Spiro. It is the FDA's desire to encourage sponsors to conduct two studies. However, that they could agree to conduct one study if the study is large enough and well conducted such as the case with the SEAMLESS. So I think that although two studies are desirable, one large study well conducted certainly have sufficed in other company's registration trial for the base and support proof.
Spiro Rombotis
And Judy, just to give more color to Ed's question, correct me if I am wrong but the two studies don't have to be in the same indication. Is that correct?
Dr. Judy Chiao
Well, I think that depends on what kind of approval that one gets. I tried to reflect it back, in general, it would be for to converting accelerated approval to full approval, I try to recall over 10 years ago that the indications might not need to be the same.
Spiro Rombotis
Edward, are you able to hear that?
And we have reached our allotted time for questions. And now I'd like to turn the floor back over to management for any additional or closing remarks.
Spiro Rombotis
Thank you, operator and thank you all for attending our conference call. We appreciate your interest in Cyclacel and also your support. We look forward to update you on our forthcoming earnings call. Operator, at this time, please end the call.
Thank you. This concludes today's conference call. You may now disconnect.
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I am currently doing a post-doc at Toyota Technological Institute at Chicago, where I am working with Karen Livescu and other awesome people on multi-modal machine learning models that combine speech and vision. I completed my PhD at the University of Edinburgh where I was supervised by Sharon Goldwater, Aren Jansen and Simon King. Before starting my PhD, I worked with Thomas Niesler at Stellenbosch University, South Africa.
My main research interests are in machine learning, speech and language processing, and computer vision. I am particularly interested in machine learning methods that can learn from small amounts of labelled data, and in unsupervised methods that can learn directly from raw unlabelled data. Can an algorithm find meaningful units and structures in a corpus of speech audio, with only minimal guidance? How much supervision is required to build a useful speech processing or computer vision system? These questions are central when building language, speech and vision systems in low- and zero-resource settings.


text:
Blonde robo-breasted babe Cyndi Pass began her show business career as Girl Dancer on the racy sitcom Married… with Children in 1991. Her legs were such a hit that they made it into the opening credits for the entire run of the sixth season. But the most Cyndi has shown in this business was as a stripper on "Sheedy Dealings," an episode of NYPD Blue, where she rubbed a pole with her G-strung bottom. Why Cyndi has taken a Pass on skin is one of the greatest mysteries of the universe.Join Mr. Skin for the full bio >>
Hindsight (1996) - as Cassandra Bennett
Bikini Island (1991) - as Kari
NYPD Blue (1993-2004) - as Wendy Spence
Renegade - as Denise Dennison
Silk Stalkings (1991-1992) - as Sherry Jarvis


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I have come up against this issue a number of times and wondered if anyone here had a way to resolve it.
A laptop comes in with a dead hard disk. No chance of recovering any info as it is dead as dead gets.
So new hard disk and reinstall needed.
The user does not have any of the disks they got with the laptop.
However looking under the laptop shows a Windows serial key.
Now the one I have at the moment just has the key with no version information.
However I have seen some that say "Windows XP" for example.
How do I know which disk I need to reinstall with? OEM? R1? R2 ? Home? Pro? Standard? Enterprise ? Volume License?
The one I have at the moment has a sticker on saying designed for Windows Vista so it is obvisouly Vista and it has a 64 bit processor so is clearly 64 and also with the sticker being attached you would assume it is OEM, but is it Professional? Home Basic? Home Premium?
At the moment the only way to tell is to go through the install process until you get to where it asks you for the key, then it says yes or no. This is a major pain in the ass.
Is there any better way to determine which disk I need to install from?
4 Replies
Feb 11, 2010 at 7:11 UTC
Is the disk definitely completely dead? Have you run chkdsk etc? You may want to try this:
It does show version info as well as product key.
I keep a standard image for all our pc's and laptops and when there is a problem, just re-image them - Acronis True Image is perfect for the job. HDD's replaced and up and running in minutes. Clonezilla is a good free alternative too but you need to run sysprep to change the SID, whereas there is an option for this in Acronis as well being able to restore to dissimilar hardware.
Feb 11, 2010 at 8:29 UTC
Lawrie Dalman Consulting is an IT service provider.
Yep we do all of what Mark suggests, but in house have recovery images of all our systems, desktops, laptops and servers as part of our imediate recovery methodology, sometimes ASR, sometimes Acronis, sometimes System Backups, depending on OS and circumstances.
Feb 11, 2010 at 8:43 UTC
If it is Dell, have you looked up the service tag config information on the website?
If it has a 64 bit processor doesn't always mean it has a 64 bit os. Could be 32 or 64. Recently if they drop 4 gigs of ram in it, is when it will be 64 bit os. I have seen many manufactures have 64 bit chip, 2 or 3 gigs of ram and run a 32 bit os.
The OEM sticker should tell you "Home" or "Pro" at least.
Volume licences don't come with stickers to put on the box. That is just Retail and OEM that gives you stickers.
Feb 11, 2010 at 9:39 UTC
KS Services is an IT service provider.
Using a tool to recover the version and product key isnt an option as the drive doesnt even spin, it is dead in the deadest way possible.
Keeping images is not an option as this is a home user support service and it is never the same customer/machine twice.
The laptop is an Acer so the dell option is no go.
The sticker doesnt say anything about what OS the key is for it just has the serial key.
I didnt think there would be a way but thought it was worth asking :(
This discussion has been inactive for over a year.
You may get a better answer to your question by starting a new discussion.


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NCMC, McKee, MCR rank in top 5 percent of hospitals nationwide
January 24, 2013
Three regional hospitals were named to the Distinguished Hospital Award for Clinical Excellence in 2013.
Banner Health's North Colorado Medical Center and McKee Medical Center, as well as Medical Center of the Rockies, based in Loveland and run by University of Colorado Health, were ranked among the top 5 percent of more than 4,500 hospitals nationwide for clinical performance. The award is given and measured by Heathgrades, a leading provider of comprehensive information about physicians and hospitals, according to a news release from Banner Health.
"We are happy to be nationally recognized for the dedication and investment in clinical quality and patient care," said McKee CEO Marilyn Schock in the release.
NCMC CEO Rick Sutton added in the release: "This is further evidence that our employees remain focused on our priorities to make a difference in people's lives through excellent patient care."
For more information about Healthgrades, to download a full copy of the report or to get information about hospital and physician quality, go to http://www.healthgrades.com.
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NRF 2014: Tailoring technology for omnichannel success
By Leonie Barrie | 21 January 2014
Engaging more deeply with customers, and offering a seamless capability no matter where or how they shop, is set to remain one of the biggest challenges for retailers in the year ahead according to experts at Retail's 'Big Show,' the National Retail Federation's 103nd Annual Convention & Expo that took place last week in New York.
If there was one message that came through loud and clear over the holiday trading period, it was that those retailers managing to offer a coordinated shopping experience across multiple channels were the stand-out winners.
The last few years have seen a seismic shift in consumer behaviour: consumers no longer "go" shopping; instead they are always shopping. Whether at work, in the store, on the sofa, or out and about, they use technology to research, browse, buy and discuss their experiences.
For retailers, smart investments in omnichannel ensure that product information is accurate and consistent across all touch points, whether in-store, traditional websites, mobile apps or social media.
They can also help to improve conversion rates, build brand loyalty and repeat sales, and even capture customer demand from international markets.
But engaging more deeply with customers, and offering a seamless capability no matter where or how they shop, is easier said than done.
And it is set to remain one of the biggest challenges for retailers in the year ahead according to experts at Retail's "Big Show," the National Retail Federation's 103nd Annual Convention & Expo that took place last week in New York.
"Consumers don't think in terms of 'channels,' and neither should retailers," says Lori Schafer, SAS retail executive advisor and co-author of 'Branded! How Retailers Engage Consumers with Social Media and Mobility.'
"They think 'I need to buy shoes today,' rather than, 'I'll buy shoes from this retailer's website instead of driving to their store today.' She's going to buy shoes in the most convenient way. The retailer who moves fluidly in this channel-agnostic environment wins."
Schafer points to several trends influencing the omnichannel retail experience, including:
- BYOD (Bring your own device): A handheld device like a tablet or a smartphone is now standard for shopping and gathering product and pricing information on the fly.
- On-the-go check out: Traditional in-store point-of-sale (POS) systems are giving way to mobile checkout as sales associates carry tablets and consumers use their own devices to check out.
- In-store beaconing: Displays with electronic sensors use consumers' phone signals to count how many shoppers walk past a particular display, how many stop to browse, and how frequently someone returns to a store.
- In-store Wi-Fi: Retailers are installing in-store Wi-Fi for customers' convenience and to offer customised, localised promotions and incentives directly to individuals.
- Analytics: Retail analytics is as valuable a currency as half-off promotional codes in the omnichannel environment. Without analytics revealing facts to support decisions, retailers operate on gut feel - not good business decisions.
Retail analytics
Retail analytics, in particular, seems to be one of this year's buzzwords when it comes to helping retailers compete more effectively across sales channels.
Analysing data can help companies make precise decisions about everything, from crafting relevant offers for on-the-go consumers to displaying the right assortment of merchandise.
"A consumer essentially carries around a whole store on the smartphone in his or her pocket," says Brian Kilcourse, RSR Research managing partner.
"Retailers know they need to upgrade their technology portfolio to understand consumers' complex path to purchase. It's critical for them to reach customers in new ways, and that can only happen if retailers gather and analyse customer data."
According to analyst Greg Girard of IDC, "there are two overarching forces driving requirements for better omnichannel analytical insight: the reach for relationship, relevance and reciprocity for customer intimacy and the search for scale, speed and scope for supply chain mastery."
The retail supply chain is traditionally broken into two distinct silos: the "back-office" supply chain encompassing the flow of goods between manufacturers, wholesalers and the retailer's DCs, and the customer-facing supply chain encompassing merchandise management, e-commerce and catalogue, stores, and consumers.
With key data spread across multiple systems, buyers, planners, allocators, store operations and marketers often struggle to get enough visibility into the entire supply chain to answer questions like: When will the items we're heavily promoting arrive in-store? On what days should I increase store staffing to receive a large merchandise shipment? Can I commit to a specific date for shipping backordered e-commerce or catalogue items directly to my consumers? When should I invite my best customers back to the store to see new merchandise? Should I airship merchandise to capitalise on an immediate selling opportunity to my best customers?
Jeff Buck, CEO of QuantiSense, says gaining deep, detailed visibility into the supply chain lets retailers "make better decisions about merchandise management, promotions, events, store staffing, the omnichannel experience and more, ensuring that customers always get the items and service they want and expect."
A new whitepaper from eCommerce and multichannel retail consulting firm FitForCommerce also suggests omnichannel strategies require more than simply adding additional channels.
The paper, 'PIM for Retailers: The Importance of Product Information Management in Omnichannel Retail,' says these tools are key to helping retailers collect, manage and share product information across all internal departments and with external partners and suppliers, creating a single source of product information across all relevant touch points.
RFID in retail
However, according to Dr Bill Hardgrave, dean of the Harbert College of Business at Auburn University and the founder of the RFID Research Center, apparel retailers need to "solve the fundamentals first" before starting to focus on enhancing the customer experience.
This means inventory accuracy. "If you haven't started addressing the fundamentals, you are behind," he says.
When it comes to global RFID adoption, not only is this accelerating in apparel retail, but two out of three of the top 30 retailers in US already have RFID initiatives in play, a panel session heard.
"If you're not doing it now, you're already behind, and if that doesn't scare you, it should," Dr Hardgrave advises.
Pam Sweeney, Macy's SVP of logistics, systems and technology, believes: "RFID is about sales growth and improving customer experience. We're moving forward with additional categories and penetration into existing categories.
"The greater the penetration of RFID throughout the supply chain, the greater the benefits we see.
Meanwhile, Francisco Melo, VP of global RFID at Avery Dennison Retail Branding and Information Solutions (RBIS) added: "We're seeing a significant number of retailers piloting and adopting RFID around the world.
"This is due to the return on investment RFID delivers, its ability to significantly improve inventory accuracy and the simplification of implementation."
As retailers rapidly scale-up their RFID rollouts, solutions to shorten the time-to-value and reduce the inherent risks in such a move are coming to the fore.
A new global partnership between Checkpoint Systems and RGIS has been set up to help, offering a full RFID-based inventory management solution that combines the Merchandise Visibility Solution from Checkpoint with RGIS's global team of inventory specialists.
"The benefits of RFID for inventory management are well-documented, with accuracy increasing from around 65% to 98% or even higher," adds Dr Hardgrave.
"But as with many innovations, as they become more routine, compliance to the standard operating procedure can wane, so it becomes important for retailers implementing RFID to take steps to ensure continued compliance to provide consistently high accuracy and payback from the investment."
Click here for a round-up of some of the latest launches and developments at this year's NRF 'Big Show'.
Sectors: Retail, Technology
Companies: Avery Dennison Corporation, Macy's Inc
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Peace Leader Camp – Day 7 – August 6th
Today we spent time closing our week together, thinking about what we want to take from our week growing as peace leaders back into our home communities.
We began our day with extra special Kids4Peace-only interest groups – led by our wonderful Counselors-in-Training! The CITs taught us how to become ninja masters, brush up on our handball skills, and Zumba around the world, just to name a few.
After lunch we spent some time relaxing together and being silly around our lodge, enjoying the last day together as a group. It was a hot one, so we were super glad to head down to the waterfront for a bit! We were able to go boating again today, one of our favorite activities!
Once we were all cooled off, we set off on a scavenger hunt throughout camp to search for the values we are going to take home with us. We were led to the smoothie bike, arts & crafts lodge, garden, activity center, everywhere! We then spent some time sharing with our Peace Pods what values are most important to us and what they mean to us individually. A lot of people discussed taking the values: healthy risks, perspective, empathy, creative solutions, and tolerance home with them.
We then spent some time preparing for the Celebration of Learning tomorrow. We are so excited to see you all and share how we have learned and grown this week with you!
To close our day, we came together around a campfire. Our Jewish friends lit the havdalah candle, signifying the end of Shabbat. We had some time for more questions before we moved into our closing festivities.
Our campfire was brought in via torches on canoe, thanks to our wonderful cooks! We shared what being a peace leader means to us, and lit the candles of those around us. The closing campfire was a reflective time for us all to come together and think about what we have learned and where we are going.
We are excited to see our families tomorrow at the Celebration of Learning and share even more about our wonderful week!
K4PB Camp 2016 – Day 6 – August 5
Today we were glad to all come together again after our grand adventures yesterday! We traded tales of our hikes, camping out, and making s'mores. Today began the weekend of sharing our traditional weekly faith practices together.
After settling back in at camp, we made challah together in preparation for Shabbat dinner. The campers enjoyed braiding their bread, learning about the tradition behind challah, and decorating their breads with cinnamon sugar, chocolate chips, and raisins! It was fun to play with our food!
We enjoyed a delicious lunch in the eating lodge with an especially long round of song challenges. We are doing a great job learning the camp songs and sing them passionately!
After lunch, we watched our Muslim friends make wudu and pray Jum'ah. It was a quiet time to pray for those of us who are Muslim and a quiet respectful time to observe for those of us who are not. Afterwards, we spent time asking questions and learning bout one another's tradition.
We cooled off in the lake with a rousing game of water volleyball and some swimming to break up our afternoon. Our competitive sides really came out!
Once we cooled off, we shifted gears and spent some time returning to the ideas that we have worked so hard on all week. We participated in an activity where we were each given a new identity, faced with difficult circumstances and situations. We discussed the ways we could step into action in response to these circumstances, as the person with the identity or as a bystander. We thought about the needs we see most clearly in our communities, and the ways that our voices can be heard best.
Before dinner, our Jewish friends lit the Shabbat candles and did the Kiddush, while we respectively observed. Over a delicious Shabbat meal we asked questions and learned about our Jewish friends' practices.
After dinner we had a ton of fun sharing our talents with our Kids4Peace community during our talent show. With a Hamilton rap, a motivational positive speech, magic tricks, Hebrew tongue twisters, soybutter and jelly silly hands, gymnastic tricks, and telekinesis, we were laughing the whole time!
We are all excited to head to bed early tonight after our long day today, and are looking forward to our special Kids4Peace interest groups tomorrow!
To see more of the fun we had, view the pictures from today here!
K4PB Camp 2016 – Day 5 – August 4
As always, we've packed our day full with the sort of playful, silly, and joyful activities that make a camp day oh so sweet! In fact, today was one of the highlights of camp…our hike! You won't believe how amazing the views are from the top of the mountain, but our sore legs sure are a testament to the heights we climbed! Check out photos from the hike and more at this link:
But one of the things that makes Kids4Peace so special is that while we're pushing ourselves to climb mountains and form new friendships, we're also constantly focused on what it means to be peaceful and what it takes to make the world more peaceful. Recently we had the opportunity to share our thoughts with the other campers at Merrowvista. Here's a blog update from Merrowvista's website that describes the experience from their perspective (see the original at this link here):
On Sunday, Merrowvista welcomed Kids4Peace campers to our community. Kids4Peace brings Muslim, Jewish and Christian young people together for a week of interfaith dialogue with the goal of building understanding and respect. From this foundation, they leave camp with skills and goals to be a Peacemaker in their communities.
These Peacemakers in training join the larger camp community for meals and for two interest groups a day. Last night, they led an Evening Reflection on the concept of peace. They shared their thoughts on what peace is and why peace is important.
Some young people referenced how things they heard on the news made them feel, both as a person of a specific faith group but also as a peacemaker wanting equality for all people. Some quietly shared their vision for peace in our world, and others spoke passionately about their desire to create change and inviting all the campers and staff to stand against prejudice and stereotypes.
They spoke from the heart, and with honesty.
"Peace … can be achieved if people will listen to everyone's opinions. The key is to have discussions rather than arguments."
"Peace allows people to be who they are. Peace to me means hope and a connection to your inner self."
"Peace to me means equality, everybody and every single stereotype being together. Peace is important because with it, everybody can be equal."
"I think some people should have more positive actions and words. Sometimes people talk about how bad Muslims are when that is really a stereotype. I'm Muslim and some people in this wonderful camp are Muslim too. We should just take time to understand who Muslims really are."
"Peace is important because it gives each religion the respect and equality it needs."
"Peace needs: Honor and Trust, Diversity, Making Friends, Love, and to get rid of Stereotypes and Racism."
"Peace means everyone getting along and feeling safe anywhere they go and not having to change themselves for safety and happiness."
The evening ended with a few minutes of quiet where campers were invited to reflect on a few questions – what peace means to them, why they think it is important, and what they think we need to do to be peacemakers. Great questions for us all to consider!
One of the most wondrous parts of living at Merrowvista each summer is that it is a community created and cared for by our campers. Our staff facilitates and guides, but the power of this community is that what is created is theirs – the campers'! We begin each day with their thoughts on topics important to them, and often end our days with their voices. Their own, best selves bring the values to life. It is hard work, but filled with learning. Listening to the Peacemakers share last night, and watching our campers listen thoughtfully and respectfully, brings such hope for the future! If only all adults had the chance to really hear what these wise campers have to say.
Peace ~ Salaam ~ Shalom
K4PB Camp 2016 – Day 4 – August 3
Today was another great, full day! The Counselors-in-Training really stepped-up their leadership role in planning much of the day's happenings. We started with a guided meditation in the morning, which was focused on the importance of thinking before acting. When breakfast finished, we had fun doing Arlos (washing dishes for the whole camp) and sang lots of songs while doing so. Daniel Anderson, the Assistant Program Director, also came to join for the day, arriving just in time to visit some of the interest groups shared with our host camp and campers. During our afternoon Discovery Block, our focus was on privilege and perspective, and we portrayed these issues through a challenging, yet fun, game called Monster Mash. After so much powerful conversation, we went to relax and play at the lake, and our fun there included balance competitions on the paddle boards. Entering late afternoon, we took more time to plan more of our various presentations on our religious traditions. After a '50's themed dinner, we returned to our lodge to dive more deeply into the concept of privilege and how to address it within ourselves and others through engaging and powerful activities led by the Counselors-in-Training.
To see pictures from the day:
K4PB Camp 2016 – Day 3 – August 2
Day three has been great! We've all come together and are integrating well. The youth had the opportunity to make many new friends at our host camp through joining them in various Interest Groups: archery, diving, football, paddle boarding, sailing, mod podge, and many more. After this, we all gathered together again to discuss why we're here with Kids4Peace, the issues facing our respective communities, and the importance of taking risks as a peace leader. When we finished, everyone headed to the lake to relax, swim, and paddle board. Dinner was Taco Tuesday, and afterwards we hung out with the Green Team to learn about the compost and gardening system used here at Camp. For evening reflection, our Kids4Peace Boston campers had the chance to share their thoughts on the importance of creating a peaceful world, and they did so with strength and passion. Our long, full day was closed with small group conversation and sharing. Now we're looking forward to another great day tomorrow!
To see come pictures from this morning's activities:
K4PB Camp 2016 – Monday, August 1
Goal setting – working together as a team – challenging ourselves: these are all themes of our second day at camp. Wow – what a busy day! We began by setting goals for ourselves. Examples of the many things campers mentioned are: getting to know new people, learning something new about a different religion, trying a new activity, and having fun! Our boys and our girls each had a turn to work together as a team on the challenge course, including the Whale Watch which required that each group figure out how to balance on a large wooden platform without talking! Both the boys and the girls group worked amazingly well together! (Check out the pictures to really figure out what they had to do.) Candle -making allowed campers to discuss the recipe for a successful week at camp, and a session on the indoor ropes course enabled campers to challenge themselves individually as well as support and encourage their peers through their challenges on the ropes course. All of the day's activities showed that small things make a big difference (to others and to ourselves) when building a community and working together as a team. After spending the evening singing around the camp fire with our host camp – including performing a song for the entire camp, we closed the day by practicing intentional listening in pairs learning why each camper chose to come to Kids4Peace camp.
Oh, and in between all of this we had another fabulous swim in the lake in the light rain! Everyone will sleep very well tonight!
CLICK HERE to see photos from today!
K4PB 2016 Camp – Day 1 – July 31, 2016
Kids4Peace Boston Peace Leader Camp has finally begun! A little rain did not stop the campers and staff from having an incredible first day. We spent time connecting and re-connecting, both new campers and returning campers, and getting to know the camp routine. After settling into our rooms and playing some get-to-know you games, we took swim tests in the lake. Swimming in the lake in the light rain was quite peaceful! After a dinner, filled with energetic singing (a tradition at Camp), a treasure hunt helped all K4PB campers get to know their way around these beautiful surroundings. During the evening activity, we shared the story of Abraham's tent – found in all 3 Abrahamic faiths – which laid the groundwork for the hospitality and generosity we all want to offer each other at camp and reiterated the commonality among our religions. During our "closing the day" session (a time for all to reflect on and share thoughts about their day), many mentioned how excited they were to finally be here after so many months of thinking about camp and how much they are looking forward to a full day of activities tomorrow. The Kids4Peace Boston CITs (counselors in training; all 11th and 12th graders who have been in K4PB since they went to camp after 6th grade) are amazing role models, helping campers get to know one another, leading games, and just making sure all are having fun.
One of the staff members said that the K4PB campers brought the sun to camp even when the sky was cloudy!
K4PB Camp 2016
The AMAZING staff and Counselors-in-Training (CITs – 11th and 12th grade Kids4Peace Boston participants) can't wait to welcome the Kids4Peace Boston (K4PB) 7th and 8th grade Peace Leaders to Camp on Sunday! We have been preparing to make the week at camp more EXCITING and FUN than ever before. We have incredible activities planned and will make the most out of the beautiful setting at Camp Merrowvista (our VERY generous host for the week).
We know that parents and families will want to follow along. So check here daily for updates and a link to photos on facebook.
See you at the bus on Sunday morning!
K4PB Camp 2015 – Friday, August 7
Another exciting, action-packed day at Kids4Peace! After an early start and a sad goodbye to Camp Merrowvista, our home for the last 8 days, we loaded our bags onto the bus and headed back down to Boston. The amazing singing talent of our kids was showcased all the way back from camp to the delight of the staff. All of the kids promised to keep their day jobs.
Our first stop today was the Islamic Society of Boston Cultural Center where we had lunch before a quick tour and Jummah prayers. After prayers and a compelling sermon by a guest Imam, we sat with our friend Nancy who answered a number of thoughtful questions we had about the service and Islam in general. She was very knowledgeable about the history of the ISBCC and commiserated with us about the difficulties of parking in Boston. She spoke about peace in Islam and helped us understand more about the practice of Islam in Boston and in other parts of the world.
After the masjed, we moved into our new accommodations in Newton, MA and enjoyed some easy time and a fabulous PIZZA DINNER!! Although we miss Camp Merrowvista, we certainly can't complain about the pianos we can play, the beautiful soccer fields, comfy beds, and air conditioned rooms! We then walked to Temple Shalom of Newton where we had another quick tour before song filled Shabbat services. Rabbi Gurvis and Rabbi Abrasley spoke passionately about the importance of keeping an open heart and bravely loving others…even if you don't get along with them. The congregation praised us for the hard work we're doing, reminding us all that what we're doing at 12 years old, some people never do in an entire lifetime! They even showed their gratitude and support with ice cream during the Oneg! Woohoo!!!!!
After the walk back (we got in about 3 miles today) the kids got ready for bed, Gabe turned into a soap zombie but he seems to have gotten better. Long story short it was a long day! And we look forward to a slower paced Shabbat day tomorrow while we await our Church visit on Sunday.
K4PB Camp 2015 – Thursday, August 6
What a beautiful last day at Camp Merrowvista!
We spent the morning reflecting on our time here together through a camp-wide scavenger hunt that reminded us of everything we have done and worked on so far. Hidden on trees and rocks and by buildings and benches, campers found slips of paper with words and themes from our week, such as "perspective," "community," and "empathy" among others. We shared with our peace pals which themes spoke to us the most, reinforcing the importance of the activities we did around them.
We ended the day and our time in New Hampshire the same way we do every year in Kids4Peace, with a campfire and songs! Each peace pod prepared their favorite song to lead the rest of the group in as we enjoyed the stunning mountains around the lake for the last time.
We asked all the kids to spend a moment and reflect on what they are grateful for and what they appreciated here in Kids4Peace. Here is just a small sampling of the thoughts they shared:
"I'm grateful to be here and meet new people and help change the world."
"This couldn't have been possible if everyone hadn't tried, and we all had a heart and did try."
"I'm grateful for Merrowvista giving us a place to stay at night."
"I'm grateful for all the people here who have good hearts, because you have to have a good heart to make peace."
"I'm grateful this isn't the end."
And we are too! This is not the end of our time together as we pack up to head down to Boston bright and early tomorrow morning. It was also mentioned many times by campers around the fire how grateful they were to have their peace pals here and we can't wait to enjoy the rest of our time with them!


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Feeds plants for up to six months, Specially Formulated Mix Contains AquaCoir To Absorb Excess Water and Release It Gradually To The Roots As Needed Reducing Plant Stress, Enriched With Miracle-Gro Plant Food For Stronger Health


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MILFFavorites [+]
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Running Time: 77 minutes
Released: 04/2013
Studio Name: Viv Thomas
Director: Kendo
Description: There is something special about a MILF, a woman who knows what she wants and how to get it. She exudes a certain confidence and gravitas that makes men yearn for the experience. Filmed in true Kendo style, this film is to be a winner with MILF lovers the world over. Featuring award winning super MILF Tanya Tate, with Karina Currie, Rebecca More, Daniella Aire, and Alexis May.
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Get Your Dog Care Questions Answered by Experts
Hi LhasaLover,
This breed is prone to corneal ulcers and with this you may see a cloudiness of the cornea, red conjunctiva, squinting,rubbing at the eye and mucus or pus draining from the eye. Treatment can be drops to prevent infection, atropine to relieve inflammation or surgery. You can read more on this here. http://www.petplace.com/dogs/corneal-ulceration-in-dogs/page1.aspx
This could also be cataracts as that will show a bluish hue to the eye. If it is cataracts then there is not treatment except surgery and usually a vet will wait until it hits a certain stage. http://www.petplace.com/dogs/cataracts-in-dogs/page1.aspx


text: The previously mentioned fuel initiatives are also expected to hold a major cost-saving potential.With a number of initiatives in such areas as procurement and crewing, TORM has also managed to keep OPEX significantly below the 2008 level despite the underlying inflationary pressure. TORM is well on the way to delivering on a cost program of USD 100 million in accumulated savings between 2012 and 2014. *** TORM has now created a financial and operational platform for the coming years, which will give the Company time to find a more permanent capital structure. The "One TORM" measures will strengthen TORM's long-term foundation. Proposals submitted by the Board of Directors Finally, before rounding off my report, I would like to make a few comments on the remaining part of the notice to convene this meeting, which once again this year includes proposals from the Board of Directors. However, these are far less extensive than last year, when the proposals included a number of authorizations in connection with the restructuring process. Proposal 7.a. is prompted by the existing Danish corporate governance recommendations issued in 2011 and, accordingly, the Board of Directors proposes that the shareholders at the General Meeting approve the level of remuneration for the Board of Directors for 2013. Proposal 7.b. concerns an authorization to terminate the Company's American Depositary Receipt ("ADR") program and in this connection allow the Company to acquire treasury shares as well as delist the Company's American Depository Shares ("ADS") from Nasdaq Capital Market, USA and deregister the Company's securities under the U.S. Securities Exchange Act of 1934. The Board of Directors finds that this would be in the interest of the Company due to the limited size of the ADR program and the costs involved with a listing on NASDAQ and the reporting and filing obligations under the U.S. Exchange Act. The ADR program represents approximately 0.5% of the Company's total share capital following the capital increase carried out in connection with TORM's restructuring in November 2012.


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The UBS Libor settlement swings the spotlight on to the role of interdealer brokers in the burgeoning scandal, alleging that employees at these institutions actively "colluded" with rate-fixing efforts – and were handsomely rewarded for it.
According to the final notice published by the UK Financial Services Authority, four UBS traders worked through the brokers to try to influence the Japanese yen Libor submissions at other banks. The watchdog says the traders made more than 1,000 requests to 11 employees at six interdealer broker firms.
UBS then paid brokers through wash trades that had no purpose other than to generate fees, and at one point the bank was paying £15,000 a quarter to the brokers for a period of 18 months, the FSA said.
Interdealer brokers act as conduits in the market for large and illiquid trades, talking to a range of bank traders, both by phone and electronically, every day. They do not participate in the daily Libor rate-setting process, in which a group of panel banks submit their estimates of the interest rate they would have to pay to borrow that day and the results are then averaged to set the official benchmark.
The FSA alleges that UBS traders used the middlemen to pass on requests for specific rates to traders at other banks. They also asked the brokers to place false bids and offers – known as "spoofs" – and asked them to manipulate the rates shown on their trading screens to skew market perceptions of the rates and indirectly influence other banks' submissions to the Libor rate-setting process.
In one particularly dramatic example, the FSA notice quotes a UBS trader saying: "if you keep 6s [the six-month yen Libor rate] unchanged today … I will [expletive] do one humongous deal with you … Like a 50,000 buck deal, whatever … I need you to keep it as low as possible … if you do that …. I'll pay you, you know, 50,000 dollars, 100,000 dollars… whatever you want … I'm a man of my word".
Up to now, only three interdealer brokers – Icap, RP Martin and Tullett Prebon – had acknowledged receiving information requests from authorities in connection with the global investigation into Libor. Icap and RP Martin have suspended employees or put them on leave in connection with the investigation, but Tullett Prebon said as recently as last week it had not. All three firms have said their institutions were not under investigation.
Two employees of RP Martin and a UBS trader were arrested last week as part of the UK Serious Fraud Office's Libor probe. They were bailed without charge pending further investigation.
The Swiss regulator Finma said in its UBS settlement documents that a single trader, dubbed Trader A, made several hundred requests to different brokers asking them to help influence the rate. The watchdog said Trader A promised brokers additional business and conducted wash trades as a reward for their help.
Its settlement document describes an email exchange between that trader and a broker in August 2008, in which the trader says, "obvious could do with low 6m tonight" and the broker replied, ":-) yep with you mate, low everything" and went on to ask if the trader thinks the broker "is your best broker in terms of value added :-)"?
Trader A responded with a reassuring "yeah, I reckon I owe him a lot more".


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We have all the information you need about public and private Plastic Surgery Clinics that provide hymenoplasty in Seoul. Compare all the plastic surgery clinics and contact the plastic surgeon in Seoul who's right for you.
Looking for Hymenoplasty? Choose from 4 Hymenoplasty Clinics in Seoul and compare prices, patient reviews, and availability. Find the Best Price for Hymenoplasty in Seoul. Compare how much Hymenoplasty cost at all 4 clinics and save money on your treatment.
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+ Nose .- i has flat nose
+ Lips- i has thinned lip Good Service , i feel comfortable , caring & warm from DR cho , Nurse & consultant Name :yumi !
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GraphicRiver Restaurant Print Set
Category: Graphic
GraphicRiver - Restaurant Print Set "Milkshake" | 80 MB
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Restaurant Print Set 揗ilkshake?br /> Files are structured in folders for easy editing. Change text, edit colors, move items. All text styles and objects are included. Quick Replacement image
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text:
is one of Wikiality.com's game-like activities
Questions on how to play | Newest stuff | All games
Already the Russians and Canadians are trying to claim America's North Pole.
Now, Denmark is trying too as well!
Wikiality.com has been given the rights to oversee countries that are bidding for claim over America's North Pole by The Greatest President Ever.
So, like the International Olympic Committee, Wikiality.com will allow one submission for each nation to see who can claim the rights to America's North Pole.
Please post your claims below.
- Because our name is already in the title.
- Because we own America
Saudi ArabiaEdit
- Because we own your royal family.
- This creepy country has already claimed the most of the arctic circle, but here's an idea America, CLAIM AT LEAST 1 PERCENT OF IT! Or just claim take over Australia, OK!


text:
285 reviews
- Institute, WV
- 4 Year
- AcademicsB
- ValueC+
- DiversityA
- CampusC+
- AthleticsC+
- Party SceneC+
- ProfessorsB
- LocationC-
- DormsB
- Campus FoodC+
- Student LifeC
- SafetyB
West Virginia State University is ...
Public, HBCU
Athletic Division
NCAA Division II (with football)
Athletic Conference
West Virginia Intercollegiate Athletic Conference
West Virginia State University Rankings
Niche rankings are based on rigorous analysis of key statistics from the U.S. Department of Education and millions of reviews.
Acceptance Rate
SAT Range
ACT Range
Application Fee
High School GPA
Application Website
Will You Get In?
Test Scores and GPA for West Virginia State University
Net Price
$8,870/ year
Average cost after financial aid for students receiving grant or scholarship aid, as reported by the college.
Based on faculty accomplishments, salary, student reviews, and additional factors.
Student Faculty Ratio
Evening Degree Programs
- 60%
- of students agree that professors put a lot of effort into teaching their classes.20 responses
- 63%
- of students agree that it is easy to get the classes they want.19 responses
- 63%
- of students agree that the workload is easy to manage.19 responses
Most Popular Majors
Liberal Arts and Humanities65 Graduates
Elementary Education44 Graduates
Criminal Justice and Safety Studies38 Graduates
Business Administration and Management37 Graduates
High School Education37 Graduates
Communications29 Graduates
Psychology29 Graduates
Social Work and Youth Services26 Graduates
Parks, Recreation and Leisure Studies24 Graduates
History19 Graduates
Full-Time Enrollment
Undergrads Over 25
Pell Grant
Varsity Athletes
What one word or phrase best describes the typical student at this school?
Based on 9 responsesReport
Campus Life
Freshmen Live On-Campus
- 40%
- of students say Greek life is pretty low-key and has little effect on the social scene.20 responses
- 38%
- of students say varsity sporting events are attended, but not a huge part of campus life.26 responses
What one word or phrase best describes your school?
Based on 12 responsesReport
After West Virginia State University
Median Earnings 6 Years After Graduation
$29,500/ year
Graduation Rate
Employed 2 Years After Graduation
- 85%
- of students feel confident they will find a job in their field after graduation.13 responses
Colleges like West Virginia State University
- C+Fairmont State University
- 4 Year
- Fairmont, WV
- 572 reviews
- CGlenville State College
- 4 Year
- Glenville, WV
- 262 reviews
- CConcord University
- 4 Year
- Athens, WV
- 431 reviews
- C+University of Charleston
- 4 Year
- Charleston, WV
- 198 reviews
West Virginia State University Reviews
285 reviews
Review West Virginia State University
I love that West Virginia is unlike most colleges. The campus is a town which gives you so many more fun activities to do with friends (like dancing, dinner and football games). You can tell everyone truly loves the school and that makes it an enjoyable environment. I love WVU!
WVSU is definitely diverse. The current struggle on campus is finding a happy medium between black and white students and culture, and bridging the divide between on-campus residents and commuters. Some of the events are a little too much, and when we do have one, it just seems to be at inopportune times. Also, it's nothing like a modern, progressive college campus, and the "progressive energy" our Vice President of Student Affairs speaks of is virtually non-existent except in the board rooms where the boosters convene. Yes, I am slightly bitter; but I love this campus. I love the history and the diversity, and the different type of college experience discovered here. I might even say that coming here was a blessing in disguise, although every blessing has its burden, too.
West Virginia University is a diverse, academically-distinguished, and superb school with an involved and friendly staff. By offering unique majors and minors, hosting free lectures and events, and organizing various clubs and organizations, any student can completely immerse themselves into a positive and exciting college experience.


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Location: NC
Member since 9/1/2008
- 1 total post
- 1 review
Reviews & Stories
Looking Good So Far!
I am 4 days out from my procdure and am about half way through the peeling process. The skin underneath is very red, but most definitly smoother! I had 2 areas of dark spots on either cheek, both are completely gone along with some upper lip wrinkles. My face felt so tight today I had to put the Aquaphor back on (you're only supposed to use it for the first 48 hours) and my face feels much... READ MORE


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Antique - Vintage Lamps
Over time American lamps have evolved from simple vessels with wicks to today's table lamps. Initial kerosene lamps transcended into decorative Victorian lamps with hand painted shades, banquet lamps, piano lamps and bracket lamps. The development of electricty changed the lighting industry. Lamps no longer needed an oil font and therefore took on slim and unusual shapes. Brass, iron and bronze lamps became popular with parchment and silk shades. The shape and style of lighting was limited only by one's imagination. The chic shades and color range of glass, iron and brass offers many opportunities for modern and traditional homes. This vast array of antique and vintages lamps offer eclectic and classic interiors a sense of unique style. Choice parchment, glass and silk shades top glass antique lamps, Victorian lamps, bracket lamps and vintage oil lamps.


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Must Visit
Bahmani tombs are a major attraction of Bidar. This is a cluster of 12 tombs dedicated to the Bahmani rulers who ruled South India during medieval times.
Located in Ashtur of Bidar, these tombs are beautifully carved and engraved with quotes from Quran and other features. The best of these tombs is that of Ahmad Shah-Al-Wali. This tomb has the verses engraved in golden colour, and the paintings on the walls of the tomb also make it stand out from the rest.
All these tombs have intricately carved arches, huge domes and large mausoleums. The other attractions in Bidar are Papnash Shiva Temple, Solah Khamba Mosque and Rangin Mahal along with other attractions.
Tell us what do you think of Mahendragarh
Travel Talk
- Will Suggest 108
- My Favourite 59
- Been There 54
- Will Plan 52
- Will Avoid 28


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Elektra Luxx | 2011
Pregnant adult film star Elektra Luxx decides to quit the industry and take a job as a "sexology" instructor at the community college. But first she must wrestle with a slew of wild characters.
Jump to
Chase Me Productions
Gato Negro Films
Gravity Shack Studios
Recently retired porn star Elektra Luxx tries to make a straight living by teaching a sex class for housewives in a community center. But things start to get very complicated when a flight attendant with ties to her late rock star boyfriend asks for a favor and a number of additional factors that follow make her face up to all sorts of life choices and revelations.


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February 23, 2012
The Pritzker Group has hired Paul Carbone as managing partner of Private Equity, a role in which he will lead the firm's private equity investing activities. Mr. Carbone was most recently director and managing partner of Baird Private Equity. Pritzkers' PE team focuses on middle-market buyouts of North American companies with enterprise values between $50 million and $400 million.
+1 (206) 623.1986
901 Fifth Avenue
Suite 1200
Seattle, WA 98164
+44 (0)207.190.9809
1 Oliver's Yard
55-71 City Road
London EC1Y 1HQ
United Kingdom
+1 (206) 623.1986
155 Fifth Avenue
Suite 500
New York, NY 10010
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