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South American time zones:
CLT – Chile Standard Time
Current time in Santiago
Sunday, July 23, 2017 at 6:54:40 PM CLTSantiago will stay on CLT until Midnight between Saturday, August 12, 2017 and Sunday, August 13, 2017
when clocks are moved to Sunday, August 13, 2017 at 01:00:00CLST
Find local time and time zone for a locationWe recommend looking up by location name, not time zone name.
Time zone offset: UTC - 4 hoursCLT is 4 hours behind of Coordinated Universal Time (UTC)
Note that most places observe daylight saving time/summer time during summer, and are therefore using CLST instead in the summer. See below for details.
Time zone abbreviation: CLTFull name is Chile Standard Time
Email time zone indicator: -0400
An email sent from someone in the CLT time zone will have the time zone listed as "-0400" in the headers of the email. (However, "-0400" does not have to be in CLT, as other time zones could have the same UTC offset).For actual dates DST might be observed, look at the examples below
Where and when is CLT observed?
Areas using CLT in the winter and CLST during the summer
- Chile - mainland
Example location in CLT
- Santiago - This time zone offset is used during winter in this location
Other time zones in South AmericaGo directly through the links below, or see the South America time zone list
- AMST - Amazon Summer Time
- AMT - Amazon Time
- ART - Argentina Time
- BOT - Bolivia Time
- BRST - Brasilia Summer Time
- BRT - Brasília time
- CLST - Chile Summer Time
- COT - Colombia Time
- ECT - Ecuador Time
- FKST - Falkland Islands Summer Time
- FKT - Falkland Island Time
- FNT - Fernando de Noronha Time
- GFT - French Guiana Time
- GYT - Guyana Time
- PET - Peru Time
- PYST - Paraguay Summer Time
- PYT - Paraguay Time
- SRT - Suriname Time
- UYST - Uruguay Summer Time
- UYT - Uruguay Time
- VET - Venezuelan Standard Time
Time zones in other regions
- Africa
- Antarctica
- Asia
- Atlantic
- Australia
- Caribbean
- Central America
- Europe
- Indian Ocean
- Military
- North America
- Pacific
Related links
- Time zone abbreviations world-wide
- The World Clock - Time Zones - current time around the world
- The World Clock - Time Zone Converter - Convert between time zones

subset: commoncrawl


text:
Peppa Pig Music Set
Pinch to Zoom
Cute Peppa Pig Music Set featuring a tambourine , recorder and whistle .Create your own musical band and singalong with Peppa Pig.For ages 3+Read More »
Delivery Options
Order & Collect FREE
Order before 2pm for free delivery to your local store within 2 days.
Excluding Sundays and public holidays.
Home Delivery £4.00
Order before 2pm for home delivery within 4 working days
Delivered to home within 4 working days (excluding Sundays and Public Holidays). Delivered Monday to Friday 8am - 6pm.
Next Day Delivery £8.00*
Order before 2pm for home delivery next working day
Delivery will be between 8am 6pm, Tuesday to Saturday, excluding public holidays.
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Our Promise
While were sure youll love what youve ordered, if youre not completely satisfied, well gladly refund or exchange it. Thats our Wilko promise, and its in addition to your statutory rights.View Terms & Conditions »
Customer Reviews
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Product Description
Cute Peppa Pig Music Set featuring a tambourine , recorder and whistle .Create your own musical band and singalong with Peppa Pig.For ages 3+
Product Specification
- Brand:Peppa Pig
- Capacity:NA
- Type:Musical Toys
- Coverage:NA
- Colour:Multi
- Power:NA
- Pack Qty:1
- Washable:NA
- Size:30.1 x 17.1 x 2.2cm
- Assembly:No
- Height:30.0CM
- Material:Plastic
- Width:17.0CM
- Age:3+ Years
- Depth:2.5CM
- Model No:NA
Inspire Me
Welcome to Wilko Life, our exciting blog thats all about sharing with you the best of what we do. From the latest stories on whats new and whats hot.


text:
02/14/96 - 06:51 PM ET - Click reload often for latest version
BRUSSELS, Belgium - U.S. Gen. George Joulwan, the supreme allied Commander in Europe, early Saturday ordered the start of the biggest military operation in Europe since World War II, sending 60,000 troops into the Balkans to enforce the Bosnia peace agreement.
``I issued the activation order ... for Operation Joint Endeavor,'' he said, adding that the main forces should start arriving ``within the next 24 hours.'' Joulwan will be overall commander of the Bosnia operation.
Advance units of the force, which will include 20,000 U.S. soldiers, have already begun deploying. Fog in Tuzla, the center for the U.S. part of the operation, hampered deployment on Friday and it was not clear if the weather would be better on saturday.
The force aims to ensure Bosnia's rival armies stick to the military provisions laid down in the agreement signed Thursday in Paris. The operation is expected to last one year.
Final approval of the operation by the ambassadors of NATO's 16 member countries came a few hours after the United Nations Security Council passed a resolution authorizing NATO to deploy its force.
At the meeting of ambassadors at NATO headquarters, Joulwan had a simple message. ``My recommendation was simply `Let's go','' he said.
U.S. troops have been assigned to monitor ``zones of separation'' between the forces in northeastern Bosnia, while France and Britain oversee the rest of the country.
NATO is expected to officially take over the reigns from the UN at a ceremony in the Bosnian capital Sarajevo next week.
On Friday, the ambassadors had already approved everything Joulwan wanted, including tough terms of engagement.
``Our mission is clear, limited in time and scope and with robust rules of engagement,'' Joulwan said.
Unlike its underpowered U.N. predecessor, the NATO force will be heavily armed and commanders will be authorized to shoot first if they believe their units are threatened.
Alongside the Americans, the Bosnia force includes 13,000 British and 10,000 French. Forces from 11 other NATO nations and as many as 20 non-NATO countries also will participate.
U.S. troops will be headquartered mainly in the vicinity of Tuzla in the Bosnian federation part of the country.
The question of dealing with war crimes suspects has vexed the alliance during preparations for the force. NATO says it will be running a strictly military operation and doesn't have plans to seek out war criminals.
However, officials have said that if a suspect indicted by the war crimes tribunal in The Hague is apprehended by NATO troops carrying out their normal duties, the suspect will be arrested and handed to the court.
Among those indicted by the tribunal are Bosnian Serb leader Radovan Karadzic and his army commander Gen. Ratko Mladic.
U.N. peacekeepers were sent to Bosnia in 1992 to protect humanitarian aid convoys. The mission, however, was gradually expanded to include, among other tasks, defending mostly Muslim civilians in Sarajevo and five other ``safe areas.''
The ``safe area'' concept collapsed last July when Bosnian Serbs overran the U.N.-protected town of Srebrenica despite the presence of Dutch blue-helmeted soldiers.
But U.N. officials complained they were ordered to perform difficult and dangerous tasks without adequate resources and political support.
``The (U.N.) peacekeeping mission tried to keep the peace when there wasn't any peace to keep,'' Brian Urquhart, former head of U.N. peacekeeping, said.


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UDF problem
I have recently started to use UDF and so I am new with it. I want to calculate the average value of user defined scalar on specific face of a 3d domain and to write this value on an ASCII file at the end of time step (transient simulation) but I couldn't manage to compute it. I would appreciate any help on this. Here is the listing I have done.
/************************************************** **********************/ * UDF that calculates the average chlorine concentration at outlet face*/ /* and it prints it at external ASCII file and on GUI */ /************************************************** **********************/
#include "udf.h" DEFINE_EXECUTE_AT_END(chlorine_out_average) { static int last_ts=-1; int cur_ts = N_TIME; real time = CURRENT_TIME; real fa real fi; real tfa; real tfi; real mfi; int n; int id = 4; /* Change id number in order to corespond to right boundary*/ face_t f;
Domain *d = Get_Domain(1); Thread *t = Lookup_Thread(d, id); cell_t c; FILE *fp = fopen("usds_story.txt", "w");
begin_f_loop(f, t) { fa = C_AREA(f,t); fi = C_UDSI(c,t,1); tfa += fa; tfi += fi*fa; } end_f_loop(f, t);
mfi = tfi / tfa;
if (last_ts != curr_ts) { last_ts = curr_ts; fprintf(fp,"Time_Step Time UDS") } fprintf(fp, "%d\ %g\t %g\t14.8E\n", cur_ts, time, mfi); printf("Time Step:%d Time:%g\t UDS:%g\t14.8E\n", cur_ts, time, mfi); }
Thanks in advance
Re: UDF problem
as it tells the name, the macro DEFINE_EXECUTE_AT_END is executed at the end of the time step (in case of an unsteady simulation), or et the and of iteration (in case of a steady state simulation), so you don't need to check if you are at the first iteration within the timestep. I assume that in the variable fa you want to store the face area. the correct macro is F_AREA(f,t) and not C_AREA(f,t). Another thing, to print messages to the console, use the macro Message instead of printf.
Re: UDF problem
Moreover, the correct way to write the Area macro is: F_AREA(A,f,t) , being A the name of the variable. The output A is a vector, not a scalar.
If you want to access to C_UDSI(c,t,1) you must say who is "c". You cannot start a loop over faces, so you will be in a face "f" and call for the UDS in the cell "c". Maybe you are trying to call F_UDSI(f,t,i) ?
For many variables exists two versions, one for the cell values (macros starting with C_XXX) and another for the interpolated values in faces (macros starting with F_XXX)
Greetings, Diego
Re: UDF problem
Thanks a lot. I fix my problem but i would to help me with the parallel version of this code
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Let us know when your receive great advice so we can thank our lawyers and point others with similar questions in the right direction.Got it!
my vehicle was towed out of a parking lot then damaged in the process. and also vastly charged for 2 days in lot when it was only 3 hours.
Your cost to repair the vehicle plus the amount of the overcharge for the lot.
This is not legal advice. You should always discuss the specifics of your issue in person with an attorney. Be aware that there are time limits on all claims that depend on the kind of claim, so do not delay in seeking an attorney.Ask a similar question
how can i find out the duration of time for travis county?
I am not sure I understand. If the car was on the lot for 3 hours and they charged for 2 days, then you were over charged for two and a half days. Now if the city is the one charging you, then you have sovereign immunity issues. But otherwise, it should be straight forward.
I'm still curious as to how much i should settle for on the demand form. it was about 500 dollars. tow companies usually won't go to court and settle someone told me to put 1000 but i don't have a way to extend the amount to get to 1000
Cost to repair.
The information contained in any answer is provided for informational purposes only, and should not be construed as legal advice on any subject material. No recipients of answers should act or refrain from acting on the basis of any posting without seeking the appropriate legal or other professional advice on the particular facts and circumstances at issue with an attorney licensed in the recipient's state. The content of this Web site and/or any answers provided contains information that may not reflect current legal developments, verdicts or settlements. FAMILYLEGAL, and Attorney Runge, expressly disclaims all liability in respect to actions taken or not taken based on any or all the contents of this site. Any information sent via the Internet, this website, or e-mail is not secure and is done so on a non-confidential basis. The transmission of information on this website, in part or in whole, and/or communication with FAMILYLEGAL, and/or Attorney Runge, via e-mail through this site does not constitute or create an attorney-client relationship between FAMILYLEGAL and any recipients. The formation of an attorney-client relationship requires a consideration of multiple factors including possible conflicts of interest. Please do not convey to us any information you regard as confidential until a formal attorney-client relationship has been established. The Firm does not necessarily endorse, and is not responsible for, any third-party that may be accessed through this Web site. Permission is given for the downloading and temporary storage of one or more of these pages for the purposes of viewing on a personal computer. The contents of this site are protected by copyright and, apart from the permission stated, the reproduction, permanent storage, or retransmission of the contents of this site is prohibited without the prior written consent of FAMILYLEGAL. ATTORNEY ADVERTISING NOTICE FAMILYLEGAL is a national Law Firm. Jeffrey A. Runge is the President & CEO and is licensed to practice law in the states of New Hampshire and Massachusetts. Prior Results do not guarantee a similar outcome. We are a debt relief agency. We help people file for Bankruptcy relief under the Bankruptcy Code. FAMILYLEGAL is a registered trademark of Family Legal Service, P.C., a New Hampshire professional Corporation.Ask a similar question
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text:
On the Street - June 28, 2013
Two author book signing events will take place on Saturday, June 29 at Book World in Viking Plaza, Alexandria.
Diane Kasulis, author of Four Letters, will sign books from 11 a.m. to 2 p.m. Gerald Anderson, author of The Unicorn Murder or Victoria's Revenge, will sign books from 2 to 4 p.m.
For more information, call (320) 759-7236.
The Alexandria Cardinal Athletic Foundation welcomed Andrea Tripp, Doug Houska and Jon Cullen to its board of directors.
Other members of the 2013 board of directors include Mary Ellen Thompson, president; Jeff Restad, vice president; Andrea Nelson, secretary; Sam Steidl, treasurer; Eric Gronholz, past president; Mike Johnson; Derek Trosvig, Craig Zwilling, Sara Illies, Lynelle Brickweg and Carl Wittenburg.
The foundation is committed to serving as a capital fundraising partner to School District 206 so today's student athletes can be equipped to serve as tomorrow's community leaders.
All-Pro Childcare Center, LLC, 503 Hawthorne Street, Suite 103, Alexandria, announced the addition of Michelle Ferris to its teaching staff. Ferris comes to All-Pro Childcare with many years of teaching experience.
Nate Larson of the financial services firm Edward Jones in Alexandria recently won the firm's Ed Armstrong Award for his exceptional achievement in building client relationships. Larson was one of 1,618 of the firm's 12,000 financial advisors to receive the Ed Armstrong award.
Edward Jones provides financial services for individual investors in the U.S. and through its affiliate in Canada.


text:
Have you asked the question, "What are GMOs?"
Where did they come from?
Who creates them?
How will they affect myself and my family?
Are they dangerous?
If so, what can I do about it?
What you'll find out by listening to this audiobook:
We all need to understand the issues surrounding the controversial topic of GMOs for the sake of our health, our families, and the security of the food chain of our planet. Our very future may depend on it. This first volume in a five book series is the introduction you've been looking for.
Download this book today.
©2015 Vidda Publishing (P)2016 Vidda Publishing
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text:
In their first nine games, the Nationals scored just 36 runs, 12th-most in the National League and an average of just four a game. They are last in the NL with a .217 average, a .328 slugging percentage and 98 total bases. And that's with Ryan Zimmerman getting on base at a .486 clip - seventh-best in the NL - and posting a 1.022 OPS.
If the Nationals offense has had that much trouble with Zimmerman tearing through the season's first week, their next several weeks could be downright woeful.
All season, the Nationals' lineup has been constructed to minimize the holes in their batting order. Jayson Werth has been batting second because the team doesn't have two players it trusts at the top of the lineup. Adam LaRoche and Michael Morse, who are being counted on to drive in runs from the fourth and fifth spots, are a combined 3-for-18 with runners in scoring position. And other than Zimmerman, Danny Espinosa has been the only starter to play every game and post an OPS better than .800.
But Zimmerman is headed to the 15-day disabled list with an abdominal strain, and the team isn't likely to bring him back until the injury settles down. The Nationals will have to face the Phillies, Brewers, Cardinals and Pirates without Zimmerman, and if his injury stretches into early May, they could be looking at a four-game series with the defending champion Giants without him, too.
On Sunday, they batted Werth third, moving Rick Ankiel from the sixth to the second spot in Zimmerman's absence. That moved Espinosa up to the sixth spot, and Alex Cora batted eighth, playing third base.
That lineup gives the Nationals a good righty-lefty balance against right-handed pitchers (with Espinosa batting from the left side). But the Nationals will face left-hander Cliff Lee this week, and could struggle especially against left-handed pitchers if they're counting on power from Ankiel and LaRoche on an everyday basis. Both struggle against lefties, and LaRoche is playing with two nagging injuries (a torn labrum and a strained left groin).
To survive without Zimmerman, the Nationals will need Werth to come out of a 3-for-25 slump on last week's road trip and get on his first legitimate tear with the team. And they'll need a big improvement from Morse, who looked like a difference-maker with 15 homers in 293 at-bats last year and nine this spring. He had an opposite-field single on Sunday, a sign he might be sorting things out at the plate after admittedly being overly excited about his starting spot in left field. But the Nationals are sorely lacking in impact bats without Zimmerman, and they badly need Morse to fill some of the void left by their third baseman.
In their first nine games, the Nationals went 4-5, surviving because of their stellar end-of-game bullpen trio (Sean Burnett, Drew Storen and Tyler Clippard) and a starting staff that's overachieved. But the stress on those pitchers is about to get cranked up unless the Nationals can manage enough offense without Zimmerman.
The good news for the Nationals is, they've won four games with a .217 team average. HItting goes in streaks, and an average that low probably means some of their hitters are due to get hot. If that doesn't happen, though, and there's no Zimmerman to pick them up, things could get bleak.


text:
Miscarriages are traumatic; there is no way around it. Sometimes though, grief can turn into something very severe. Occasionally, miscarriage can lead to problems with mental health such as depression, anxiety, and Post-Traumatic Stress Disorder (PTSD).
We want to understand better why some women are affected by these severe reactions, while others aren't. More, we want to know how to help them.
The PIEPE (Psychological Impact of Early Pregnancy Events) study looks at how common, and how severe, these different conditions are. We will follow couples over 9 months, using an online email survey to find out who is most at risk of long-term mental health problems. A precursor to this research, where women completed questionnaires 1 and 3 months after losing a baby, found that around a third of women showed signs of PTSD. Many women who took part struggled with emotional distress and upsetting, intrusive thoughts reminding them of their loss.
We will also test a certain type of therapy – Acceptance and Commitment Therapy or ACT, which tries to remove the power of distressing thoughts – to see if it can help women diagnosed with PTSD.
If you have experienced a miscarriage and need to talk to someone, please call our free helpline on 0800 0147 800 between 9-5, Monday to Friday, or find more information here.
Tom Bourne, Helen Williams, Jessica FarrenHide details


text:
My name is Frank DeMilt I am a mixing engineer specializing in Hip-Hop and R&B mixing.
I'm a mixing engineer from New Jersey. I have worked in studios in New Jersey, New York and Atlanta. I have worked on hip-hop, rap, R&B songs as well as podcasts and radio interview editing.
Tell me about your project and how I can help, through the 'Contact' button above.
Endorse Frank DeMilt
Interview with Frank DeMilt
What do you like most about your job?
I like the ability to make the artists vision of their song come to life.
What's the biggest misconception about what you do?
The biggest misconception is that because I am young and haven't held a studio job that I don't know what I am doing.
What was your career path? How long have you been doing this?
I have been mixing for 3 years, I started as an intern in New Jersey then moved to Atlanta where I was a training engineer, and now I am an apprentice at Engine Room Audio in New York.
What type of music do you usually work on?
Hip-Hop, R&B
What do you bring to a song?
I bring a unique view to mixing the song, being self trained I use different techniques to get each aspect of the song to sound great.
What's your typical work process?
My typical process is to see where the artist is going with their song and try and take it there. I will do a ruff mix listen to it on multiple speakers and then go back into mix what I see needs fixed. I repeat this process two or three time until the song is perfect.
Tell us about your studio setup.
I have a home studio with KRK Roket 5 monitors, Pro tools 11 with Waves Plug ins, Logic Pro X and a Scarlet 2i2 interface.
What other musicians or music production professionals inspire you?
I am inspired by the mixes of Dave Pensado, Chris Lord Alge, and JJP
Describe the most common type of work you do for your clients.
Music Mixing and Audio Editing


text:
How many folks here are looking forward to spending Christmas with the Devil? Anyone? Well if you missed the Shyamalan produced fear flick that was directed by the Dowdle brothers you can get your chance to right that wrong on December 21st.
Find out what to expect when the horned one comes home below.
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text:
As previously reported the 7 inch casing string was set and cemented at 11,855 feet, and the lateral portion of Little Creature 1-15-14H well has now been drilled to the planned total depth of 19,430 feet. The lateral portion was drilled wholly within the target zone in the middle Bakken Formation. Currently the well is being prepared to run the production liner.
Blackdog 3-13-14H (SSN WI 25.03%)
Following the setting of the production liner in the Little Creature well, the Frontier 24 rig will move back to the Tofte 1 pad and begin drilling operations on Blackdog 3-13-14H. This well will be a middle Bakken lateral and is expected to follow the previously planned Swan trajectory that is the infill location between the Rodney 1-14H well (SSN WI 27.18%) and the Sail and Anchor 1-13-14HBK well (SSN WI 25.03%).
Samson Oil & Gas Limited
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For fantastic deals on office supplies, UK Office Direct has a huge range of notebooks, filing and archive items, diaries, desktop accessories, stationery items, pens, pencils, labels and tags all at low prices. We also stock some of the highest quality and popular online office supplies brands including 5 Star, Avery, Rexel and Bic and if you spend just £40 (ex VAT) you'll receive free next day delivery.
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Showing 1–40 of 44 results
Horizon Memory Craft 15000
When you create with fabric and thread, every project is a journey. Where you end up and how you get there is all up to you… and your machine. With wireless connectivity via your iPad or PC to the Horizon MC15000, you'll be there in no time as this model has our fastest processor to date.
The size is fantastic, with plenty of bed space for projects of all sizes. The Horizon MC15000 comes standard with our largest hoop and has the largest colour touch screen we've ever made! No matter which direction you head, the new Horizon MC15000 can take you there.
Horizon Memory Craft 12000
As long as there's a new project on the horizon, the creative journey never ends. Especially when you have a machine with as many possibilities as the Horizon Memory Craft 12000. With this amazing machine, you can create designs on your laptop or PC anywhere, anytime. Once you've created your project, simply connect to your MC12000 and start embroidering. Only Janome brings you this perfect blend of advanced technology and ease-of-use. The MC12000 has all the functionality you've hoped for in a sewing and embroidery machine, implemented in ways that are intuitive, smarter, and just more enjoyable.
Memory Craft 9900
If you are looking for a great embroidery machine, you have found it.
The MC9900 is a trim model with a unique embroidery unit that slides onto the back. It's such a sleek and clever design, you can switch back and do regular sewing without having to remove it.
The MC9900 has the most stable embroidery unit Janome has ever produced. It's precise. In fact, the stitch quality is so precise that it's possible to embroider fine lace designs on certain types of organza without a stabiliser.
It's fast too (1000 stitches per minute). And it's remarkably quiet. If you're looking for value, the MC9900 has the kind of specifications found on machines costing twice as much and with three times the learning curve. Here, everything is so easy to use because the technology is designed to make it fun.
Memory Craft 8900QCP – Special Edition
The Horizon MC8900QCP Special Edition offers any sewist the functionality, precision and ease of use, which is renowned to Janome's technology.
Creativity is about unlocking possibility. This model is not only a quilting and sewing experience to explore; it's a dream come true. Do it bigger and bolder with the Horizon MC8900QCP Special Edition.
The obvious features that jump out at you straightaway are the large 11″ throat opening, which means that you can now handle those large bulky projects with ease. Also the 10″ free arm means sewing those fiddly items like cuffs, pant legs, etc. will no longer be the hassle they have been in the past.
Other features include 9mm stitches, sews up to 1000 stitches per minute, removable AcuFeed System, remote thread cutter port, shadow-free lighting, bright backlit LCD touch screen, jog dial for fast and efficient stitch selections, huge storage compartments, cloth guide and large clear extension table which comes as standard. There is so much more so read on for further features and their benefits.
Memory Craft 8200 QCP – Special Edition
The Horizon MC8200QC Special Edition offers any sewist the functionality, precision and ease of use which Janome technology is renowned for. Creativity is about unlocking possibility. This model not only gives you a valuable quilting and sewing machine; it's also bigger and bolder than a standard sewing machine. If it's time to take a new direction then this is the machine for you. The obvious features that jump out at you straight away are the large 11 inch throat opening, which means that you can now handle those large bulky projects with ease. Also the 10 inch free arm means sewing those fiddly items like cuffs, pant legs, etc. will no longer be the hassle they have been in the past. Other features include 9mm stitches; the ability to sew up to 1,000 stitches per minute; a removable AcuFeed System; shadow-free lighting; bright backlit LCD touch screen; 10 direct stitch keys for fast and efficient stitch selections of your commonly used stitches; one-step needle plate release; huge storage compartments and much more.
Skyline – S7
The Skyline S7 comes with 240 built-in stitches, including 11 one-step buttonholes and 7 alphabets. Quilters and designers will enjoy the AcuFeed™ Flex Layered Fabric Feeding System and the automatic presser foot lift. The 11 buttonholes can be customised for stitch width, stitch density and buttonhole opening. Along with that, the 7 alphabets also go up to a 9mm width with a revised letter size and shape for increased realism and balance. Navigation through all of these features has become easier with the Skyline S7's new LCD colour touch screen.
- 240 built-in stitches
- 11 one-step buttonholes
- 7 alphabets
- Top loading full rotary hook bobbin
- USB port for adding stitches
- Stitch composer stitch creation program
- Automatic thread tension
- Built-in advanced needle threader
- Snap-on presser feet
- Easy set bobbin
- Bobbin winding plate with cutter
- Memorised needle up/down
- Automatic presser foot lift
- Automatic thread cutter
- AcuFeed™ Flex Layered Fabric Feeding System
- Variable zigzag for free motion quilting
- One-step needle plate conversion
Memory Craft 500E
Now designers can create projects to reflect their personal sense of style with the Memory Craft 500E. It's easy to personalise, embellish and monogram home décor items, garments and accessories. With 160 built-in embroidery designs and 6 fonts for monogramming, the possibilities are endless. The MC500E has a maximum embroidery size of 7.9"x11" (200 x 280mm) and an extra wide table.
Designs are easily imported through a USB and edited through the machine's advanced on-screen editing functions. Navigation through all of these features has become easier with the MC500E's new LCD colour touch screen.
Memory Craft 400E
The Memory Craft 400E is an embroidery-only model with advanced editing capabilities. You can design and create in the edit screen by selecting from the machine's built-in designs, which include 160 embroidery designs, 6 fonts for monogramming, border designs and normal sew patterns. The possibilities are endless. It's so easy for you to personalise, embellish, and monogram home décor items, clothing and accessories. The MC400E has a maximum embroidery size of 200 x 200mm. Embroidery designs are easily imported to the machine via a USB stick (up to 16GB). These imported designs can also be edited through the machine's advanced on-screen editing functions, and navigation through all of these features is so easy using the LCD colour touch screen.
The 1200D provides all the tools you need to create great ready-to-wear garments. It is three machines in one: an overlocker, cover hem, and top cover hem. It is versatile, incorporating many flatlock, blanket and overlock stitches, as well as the chain and coverstitch. You won't need to change the needle plate or foot for a rolled hem, and the upper looper system is easily converted for a cover hem or top cover hem. The 1200D automatically selects the tension settings for each stitch so that you can sew with comfort and confidence. You'll also find 28 optional feet and attachments. With all this, you are only limited by your imagination.
Mylock 744D
The MyLock 744D with electronic control is an advanced overlocker with 2 needles and 2, 3 or 4 thread overlock stitching. The differential feed ratio, which is adjustable from .05 to 2.25, provides exceptional control for handling all types of fabrics and for creating desired special effects.
Threading is a breeze due to colour-coded thread guides and a self-threading lower looper. Simply lay the thread into the guide, flip a switch, and the lower looper is threaded. The guide is automatically returned to its normal position when you turn the balance wheel. And when you lift the presser foot for rethreading, the thread tensions are automatically released so that you can draw the thread smoothly.
The MyLock 744D also lets you quickly switch to rolled hemming without changing the needle plate. A lower looper pre-tension stitch eliminates the need to change tension for rolled hems.
And for those awkward cuffs and trouser buttons, there is even a free arm conversion. So when you want to make the most of your time and get professional results, the MyLock 744D is unmatched.
MyLock 644D
The MyLock 644D includes essential features for simple serging. The differential feed system of two feed dogs virtually eliminates puckered edges on woven fabrics and stretched edges on knits. Its unique rolled hem conversion feature eliminates the need to change the needle plate, foot, or tension setting for rolled hemming. Janome has restructured the lower looper guides for easy access. Colour-coded guides are easy to follow for 2, 3, or 4 thread serging. All of the features on this machine are specially designed to make this serger the easiest to use on the market today.
MyLock 204D
The MyLock 204D gives you a wide range of serging features in one compact machine. Its sturdy design and precise Janome stitch mechanism ensures beautiful 3/4 thread operation. And the fact that it doesn't take up much space makes it an easy fit for your sewing room.
A Janome overlocker is the perfect companion machine for the developing sewist, and a must for creating professional looking garments. The new 8002DX gives you a wide range of features in one compact machine. With easy dial adjustments and bonus feet, projects will be completed quickly and effortlessly.
Fast speeds and smart design make the 1600P-QC the perfect machine for sewing and quilting! You'll find everything you need to complete projects quickly and easily: speeds of 1,600 stitches per minute make this the fastest machine on the market. A workspace of nearly 9″ x 6″ to the right of the needle gives an extra wide work area; the side-loading bobbin allows for easy access, even from a quilt frame; the automatic thread cutter cuts top and bobbin thread at the push of a button; and the ergonomic knee lift offers a full range of adjustment so you can find the size that fits you.
Darning foot and plate
Thread cutter switch
Memory Craft 4900 Quilter's Companion
It's the easy way to get creative. The MC4900QC has the computerised precision of a Memory Craft and the advanced features that make sewing and quilting time much more productive. With such a huge library of stitches, strong sewing speed, and a great variety of customising options, it's hard to know where to look first. But a good place to start is the large, backlit display. Here you can select from the 534 built-in stitches across four modes, and easily create custom combinations of up to 50 stitches each to save in one of five memory banks.
The Janome DC6030 is a really easy to use, fully computerised sewing machine that is packed with so many powerful features.
Direct stitch selection, each stitch has its own dedicated stitch button. Each stitch button has a built-in light, which illuminates when selected. The LCD screen shows selected stitch, recommended foot, default stitch width and length, which you can change to suit your requirements. It offers a choice of 3 styles of one-step buttonholes and a great range of stitches for all types of sewing.
Special features include pattern elongation of up to 5 times normal length; a new easy set bobbin system; a new style auto bobbin winder system; built-in needle threader; automatic thread cutter; needle up/down button; and an auto-lock stitch feature for precision locking off of stitches and patterns. It even has an automatic twin needle regulator and a start/stop button so you don't have to use the foot control.
The DC6030 comes complete with a large extension table and a hard cover.
CoverPro 2000 CPX
A coverstitch machine is essential for the sewist looking to achieve a professional finish. The CoverPro® 2000CPX's innovative design is based on the marriage of an industrial-style cover hem machine and a convenient home machine. The resulting union has produced a high-speed, long arm, heavy-duty cover hem machine that looks and operates like a sewing machine. With a wide triple cover hem stitch, exclusive free arm configuration, Tension Level Control (TLC) and Janome's Seam Tightening System™ (STS), the 2000CPX is the most advanced cover hem machine available.
Jem Platinum 760
The Jem Platinum 760 contains all of the great features of a full-size machine, with a smaller model's price and efficiency. This 3/4 size machine weighs just 5.5kg, but packs the full weight of other computerised sewing machines, incorporating advanced controls and a wide range of everyday functions. This makes it the ideal starter model for beginning sewists, or travel machine for classes and guild meetings.
The FM-725 is a needle felting machine – it does not sew, but uses barbed needles to mesh fabrics together. The fibres mingle to create new colour and texture combinations that simply cannot be achieved with embroidery, applique, or any other kind of needlework. It doesn't require thread, a bobbin, or any previous sewing experience.
The JR1012 is jam-packed with 58 stitch functions from 13 built-in stitches including a 4-step buttonhole. This front bobbin-loading machine has denim sewing capabilities, so it's perfect for those mending and alterations jobs but can also create sewing projects right from their beginning.
The RE1306 is a fantastic first machine for a beginner, or someone who just needs to complete that sewing job every so often.
The DC3100 is a light weight computerized machine and so easy to use. With 100 built-in stitches including 7 One-Step buttonholes, the DC3100 provides an excellent array of stitches for your everyday sewing to that special project made with love. Time saving features including one hand needle threader, needle up/down and lock stitch button to make your sewing easy.


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This step is voluntary but will seriously increase your chances of your profile getting read by other members. Tell people about yourself, your hobbies and upload any nice photographs of yourself.
Utilise our website's sophisticated search to encounter members who satisfy your needs. Or just flip through listings and encounter daters that attract you.
Discovered someone who takes your fancy? Send a message to them or just a wink and see if anything happens. With a little luck you'll be on your way to true love.
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Magical realism, masks by Peggy Bjerkanby ego on May 19, 2013 • 07:12 No Comments
I started making masks a few years ago as a result of my fascination with masks as ritual objects. This interest continues to grow and evolve as time goes on. The masks have become (for me) a commentary on life and the human condition. Although my masks are not wearable and, therefore, not used in traditional ways, I hope that they have the power to communicate ideas. I especially like to emphasize humor, wit and irony in my pieces and I hope that the masks are able to speak for themselves.
Tags: carved, ceramic mask, ceramic sculpture, dreams, engobes, face sculpture, fine art, glaze, hinges, humor, ideas, irony, magical realism, mask, maskwoman, metaphor, one of a kind, peggy bjerkan, raku, sculpture, Shigaraki, stoneware, stoneware sculpture, surreal, surreal clay, unmasked, wit


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Crave: Canvas Cutout Heels
Oh Spring, are you almost here? We are dying, dying to ditch our boots and tights in the back of the closet and break out the open toed footwear. Expand your collection of strappy sandals, with this pair of canvas, lace-up heels from We Who See. The slight wedge in the heel and the rubber sole means these babies are not only on trend, but also comfy. Great for skipping your way to happy hour at the beer garden! [$88, Urban Outfitters]


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so, some people are sayin' that sam and freddie will break up, because the episode was supposed to be ibreak up, but i think this can be about carly and gibby, for some reason( mrs benson, feeling left out) try to break sam and freddie up, and they make them kiss on the studio, or they kiss on the studio and mrs benson comes in, that's why carly is so nervous when she says they're breaking they're 2 best friends up, mrs benson freaks out and freddie runs away. but i don't really think they're going to break, and i think later on carly's room they going to find out that gibby and carly told mrs benson about them, and sam hits gibby with that thing, and sam and freddie are upset with carly, because bff don't do that to each other.
but later in ilove you sam and freddie forgive carly and freddie says he loves sam. :D
so what do you guys think?


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Wakefield Art Festival
Right down Main St in Wakefield. Should be a lot of fun! Love that town.
East Greenwich Art Festival
Newport Art Festival
SOWA Open Market in Boston
MCU Day! Ant-Man Comes Out!
It's the final film of Marvel Studios' Phase Two! Without Edgar Wright's brilliance behind it I almost lost interest...BUT! It's still an Marvel Cinematic Universe movie and it should have tiny people and huge bugs so I still wanna see it.
Newport Art Festival
Quahog Jamboree at Warwick Public Library
I will be a guest speaker at this year's Quahog Jamboree. My time slot is from 5:15 to 5:45 in the big meeting room, which just happens to be where my art show is hanging.
ART OPENING at Warwick Public Library!!!!!!!!!!!!!!!!! NEW SHOW!!!!!!!!!!!!
What's Down There?
Illustrations Inspired by a Childhood on Narragansett Bay
A New Series by Seth McCombs
A whole bunch of new stuff! The title explains what the idea is. I am resisting posting any images on line until the show goes up but I'm really stoked on this new work.
All you've seen is the Serpent of Conimicut Light. I finished that piece before Christmas so we made some prints for the holiday sales and let it out in the world as an ambassador for my new show. In the meantime folks have been asking about the original piece but it will not be for sale until this opening.
WBNA West Side SWELL Stroll
I will be at Ogie's set up with a few other people who own tents for this neighborhood wide event!
SOWA Open Market in Boston
Mother's Day at SOWA Open Market in Boston
I'll be home in time to have dinner with my mom. Bring yours to this.
MCU Day! AVENGERS: AGE OF ULTRON
I don't know what you're doing today and I don't care. It's Avengers Day in my world.
Book Signing at the Herreshoff Marine Museum
I will be doing a book signing as part of the Herreshoff Museums opening day!
Ashaway School Pop N Swap
As part of reading week some of us RI Author Association folks will be dropping in on the Ashaway school pop n swap!
Local Author Meet and Greet at Warwick Public Library
MCU Day! Daredevil Comes Out!
Does this have anything to do with me? Yes and here's why: As a kid I what they called a Marvel Zombie and though I've lost interest in following the endless cycles of their comics, I have grown up into a Marvel Cinematic Universe Zombie. You follow sports? I follow this. Today is the day that season one of the MCU connected Daredevil series comes out on Netflix. It is my sincere hope that I will manage to watch only one episode a night, when I can't work anymore.
In The Nic Of Time Sale at the Coffee Depot in Warren
The Coffee Depot has been real good to us. This sale was a great time last year and I expect this one to be just as fun.
Old Salty Dog Reading at Symposium Books in East Greenwich
Bring the kids! Reading and signing of Old Salty Dog at the fantastic independent bookstore, Symposium Books in the Dave's Market plaza in East Greenwich, corner of route 2 and Division St.
Chez Pascal Holiday Art Show
Hey, this event last year was the first time we had the book for sale to the public. Look how far we've come.
Rhode Island Authors Expo
By all accounts this event was a big success last year and we are stoked to be part of it for the first time. Meet dozens of local authors working in every genre you can think of.
Old Salty Story Time at Kids Con, RI Comic Con
I'll be doing a reading of Old Salty Dog at Kids Con, the downstairs area of the Convention Center at Rhode Island Comic Con.
Rhode Island Comic Con
This our second year doing this and we had an awesome time last year, before we even had the book out. This year I'll be doing readings downstairs at Kids Con and we'll have a table up on the main floor.
In honor of Halloween weekend, we'll have some oddities from the dark side of my imagination as well as the launch of my new project, you heard it here first, called WeirdOnauts. Also available ONLY at Rhode Island Comic Con will be another collaboration, a short comic book created, written and painted by Gabriella Shelton, Age 10, with drawings and editing by me, Age 36.
William Shatner will be there.
It's at the convention center in downtown Providence.
Storytelling: An Art Show by Deb Hickey and Seth McCombs
This project was a very cool idea brought to me by my friend and coworker, Deb Hickey. She has created a series of photo-collages and I have written text pieces to accompany them. My conceit for this project was that the viewer is being taken on a guided tour through a very strange little town. This date is for the opening reception but the show will stay up for a few months.
Sharks Come Cruisin' and Old Salty Story Time at Bucket Brewery
Our friends at Bucket Brewery are having one of their semi-regular tours and music nights with our other friends, the inimitable Sharks Come Cruisin'. It's sing-a-long sea shanties in a building full of beer. Somewhere in there, I'll be doing a reading.
Scituate Art Festival Author Series
We will be set up at the book section of the mighty Scituate Art Festival, in the parking lot of the library, right off the main drag of the festival. 100,000 attendees, they say. I only have 500 books left.
Wakefield Art Festival
This is one of a couple of events we have coming up with Festival Fete. A particular reason we like them is that they offer a youth artist program where kids can get table space to sell their work for a small portion of their profits.
This will be right on Main St in downtown Wakefield.
Thayer Street Art Festival
This is one of a couple of events we have coming up with Festival Fete. A particular reason we like them is that they offer a youth artist program where kids can get table space to sell their work for a small portion of their profits.
Boston Comic Con
I love this thing. I've been going since it was a few rooms in the basement of a hotel and it's been getting bigger every year. The 2012 show was the very first time I set up a trade show and it was a galvanizing experience. I am really looking forward to this. We will be there all three days. Jeff Smith is gonna be there too! I expect to have some cool, different stuff for this.
RIPExpo at Providence Public Library
We are stoked to be part of the first Rhode Island Independent Publishing Expo. Expect a weirder and wider variety of work at this thing. This event has the potential to be awesome and I'm excited to see what happens.
For more info check out http://ripexpo.tumblr.com/http://ripexpo.tumblr.com/


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Simon Cowell mooned by cheeky Elton John and David Walliams
David Walliams
Simon Cowell was given a shock greeting by Elton John and David Walliams yesterday as they turned around and flashed the X Factor mogul their bums.
The trio are all enjoying a holiday on the French Riviera, and cheeky Elton and David thought it would be funny to greet their friend by mooning him as their boats passed each other.
The music mogul evidently got a right eyeful as David reportedly shouted across to Simon: "I've got something for you."
David, who was with his model wife Lara Stone on holiday, obviously wasn't worried about upsetting his boss and fellow Britain's Got Talent judge.
The 40-year-old comedian then blew Simon a kiss and declared: "Love you Simon."
65-year-old Elton, who brought David along on his sailing trip with partner David Furnish and 19-month-old son Zachary, also wanted to join in the flashing fun.
Little Britain star David later took to his Twitter to tell everyone about his cheeky antics.
He wrote: "I just mooned Simon Cowell. From a boat. That is true.
"And then someone a million times more well known than me mooned Simon Cowell too."
The three men have been having a great time on the Riviera, and earlier this week David posted a photo on Twitter of his pal Simon having fun with a mystery dog.
The comedian put up a picture of the pooch climbing on the music mogul's face with the caption: "A dog sitting on Simon Cowell's face."
Sounds like they're having a great time - can we come next time?!


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Good news all you Borderland manics! T.K. Baha is alive! Turns out the guy in the room was T.J. Baja, T.K's twin brother, who is also blind. Apparently he was making calls to the bandits about how he was pollowing their mothers and invited them over to watch. Well, nice to see T.K is alright. :D
(Also, HD televisions rock! Took this picture from my digital camera and it came out so clear.)


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Latest update July 28th, 2017 12:54 AM
Guyana has, in the latest World Bank International Financial Corporation's Doing Business 2012: Doing Business in a More Transparent World report, slipped one place down the ratings to 114 out of 183 economies examined.
However, in the region St Lucia is the best spot to conduct business rated at 52 while Antigua and Barbuda follows second at 57.
Nearer to home, Guyana fares better than Venezuela which stood at a dismal 177, Brazil at 126 and Suriname at 158.
Singapore is the top country in the world whose regulations make it relatively simple to do business.
That country is followed by Hong Kong, New Zealand and the US.
Doing Business 2012 is the ninth in a series of annual reports investigating the regulations that enhance business activity and those that constrain it.
It presents quantitative indicators on business regulation and the protection of property rights that can be compared across 183 economies—from Afghanistan to Zimbabwe—and over time.
Regulations affecting 11 areas of the life of a business are covered: starting a business, dealing with construction permits, getting electricity, registering property, getting credit, protecting investors, paying taxes, trading across borders, enforcing contracts, resolving insolvency and employing workers.
The data are current as of June 1, 2011. According to the report, worldwide, 125 economies implemented 245 reforms making it easier to do business in 2010/11, about 13 per cent more than in the previous year.
The report noted that against the backdrop of the global financial and economic crisis, more economies strengthened their insolvency regime in 2010/11 than in any previous year.
Twenty-nine economies implemented insolvency reforms, up from 16 the previous year and 18 the year before.
According to the report, only two decades ago some of these 20 economies faced challenges similar to those in many lower-income economies today.
In a case, the World Bank cited Consider Norway's property registry. Today it is one of the world's most efficient. But in 1995 its paper records required 30 kilometers of shelving and were growing at a rate of one kilometer a year. Norway took steps to change this. First it merged the land department and survey information, then digitized title certificates. In 2002 it amended the 50-year-old Land Transfer Act to allow online titling.
Online registration has been required by law since 2008.
Sweden undertook a systematic review of all regulations in the 1980s. Any unjustified requirements were cut in a "guillotine" initiative.
(Mexico took a similar approach in the 1990s.) In Korea the Presidential Council on National Competitiveness, created in 2008, identified regulatory reform as one of four pillars to improve the economy's competitiveness, along with public sector innovation, investment promotion, and legal and institutional advancement.
Reviewing Korea's business regulations, the council found that 15 per cent had not been revised since 1998. The council applied sunset clauses to more than 600 regulations and 3,500 administrative rules.
Jul 28, 2017-Scrum-off is 14:00hrs at National Park Track and Field facility tomorrow Guyana's national men's Rugby team popularly known as the "Green Machine" will be seeking to re-enact the...
Jul 28, 2017
Jul 28, 2017
Jul 28, 2017
Jul 28, 2017
Jul 28, 2017
A young agronomist invaded a local bank a few weeks ago with his gang to rob it and was killed by security personnel. The... more
Facing a string of criticisms about their worldwide operations, ExxonMobil has gone on the offensive. The oil company has... more
By Sir Ronald Sanders This commentary continues the discussion on the relevance and state of US-Caribbean relations against... more
Editor's Note, If your sent letter was not published and you felt its contents were valid and devoid of libel or personal attacks, please contact us by phone or email.
Feel free to send us your comments and/or criticisms.
Contact: 624-6456; 225-8452; 225-8458; 225-8463; 225-8465; 225-8473 or 225-8491.
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Requirements for 2016
Three $100 awards are given:
- Club membership up to 49
- Club membership 50 to 99
- Club membership 100 and above
No Book of Evidence is required. In a large envelope, include the following: Garden Club name as it should appear on any award received, contact person (name/phone/email address) Garden Walk Map/Ticket, Publicity, Labeled photos of the garden walk (limit 14), educational handouts, a one page narrative that show cases the walk: brief description of gardens, number of club members and their participation, member recruitment, educational displays, etc.
The Garden Walk Evaluation by three Landscape Consultants has been eliminated and is no longer part of this award.
Mail by November 15, 2016, send envelope containing above information to:
Michigan Consultants Council
c/o Nancy (Stark) Higgins, President
1801 Sylvan Lane
Midland, MI 48640-6760
(989) 835-2394 Email: firstname.lastname@example.com
The following scale of points is used to Judge Garden Walk Awards:
- 20 Points — Clarity of map and tour schedule, and location of gardens in relation to distance
- 20 Points — Overall appearance of gardens
- 20 Points — Variety of garden types (Shade, rock, formal, water, etc.)
- 10 Points — Publicity
- 10 Points — Educational Value (Plant markers, worthy features)
- 10 Points — Club Involvement (membership recruitment, budget, members involved
- 10 Points — Miscellaneous (Floral designs, plant sales, displays, refreshments)
- 100 Points — TOTAL


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Apple Festival is probably one of the highlights of the year in my small town. It always seems to be on a sunny, late autumn day with crisp cool air which encourages you to buy a hot apple drink and eat a hog roast (not that we ever need an excuse for that!).
Here are some pictures of today's Apple Fair.


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Discover a selection of top forums bunnies amitabh on the internet. Come to share your passion on forums bunnies amitabh and meet other fans of bunnies amitabh. Then, why don't you create your own forum of bunnies amitabh ?
Welcome to the Kitten Overlords Blog!! Welcome all ye cats, dogs, bunnies and other furry creatures of the night!
kitten, overlords, blog!!, cats, dogs, #bunnies, furry, creatures, night!


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McCall's 8137; ©1965; Misses' Dress in Three Versions. Long waisted dress, with double breasted bodice and five section skirt, may be sleeveless or have above-elbow length set-in sleeves. Notched shawl collar, cut in one with bodice fronts, is faced and interfaced. Skirt has pleat and left front in wrap-around effect. Dress with sleeves may have contrast skirt. Collar, fronts and lower edge of bodice and sleeves are trimmed with machine stitching.
Links to reviews/blog posts Edit
Sources/Vendors Edit
Gallery Edit
Wishlist Edit
[insert your username, and make sure your preferences allow for people to contact you via e-mail. Do not list your email address here!]


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|Home | About | Journals | Submit | Contact Us | Français
The prevalence of childhood obesity has increased worldwide, which is a serious concern as obesity is associated with many negative immediate and long-term health consequences. Therefore, the treatment of overweight and obesity in children and adolescents is strongly recommended. Inpatient weight-loss programs have shown to be effective particularly regarding short-term weight-loss, whilst little is known both on the long-term effects of this treatment and the determinants of successful weight-loss and subsequent weight maintenance.
The purpose of this study is to evaluate the short, middle and long-term effects of an inpatient weight-loss program for children and adolescents and to investigate the likely determinants of weight changes, whereby the primary focus lies on the potential role of differences in polymorphisms of adiposity-relevant genes.
The study involves overweight and obese children and adolescents aged 6 to 19 years, who participate in an inpatient weight-loss program for 4 to 6 weeks. It started in 2006 and it is planned to include 1,500 participants by 2013. The intervention focuses on diet, physical activity and behavior therapy. Measurements are taken at the start and the end of the intervention and comprise blood analyses (DNA, lipid and glucose metabolism, adipokines and inflammatory markers), anthropometry (body weight, height and waist circumference), blood pressure, pubertal stage, and exercise capacity. Physical activity, dietary habits, quality of life, and family background are assessed by questionnaires. Follow-up assessments are performed 6 months, 1, 2, 5 and 10 years after the intervention: Children will complete the same questionnaires at all time points and visit their general practitioner for examination of anthropometric parameters, blood pressure and assessment of pubertal stage. At the 5 and 10 year follow-ups, blood parameters and exercise capacity will be additionally measured.
Apart from illustrating the short, middle and long-term effects of an inpatient weight-loss program, this study will contribute to a better understanding of inter-individual differences in the regulation of body weight, taking into account the role of genetic predisposition and lifestyle factors.
The global increase in childhood overweight and obesity is a serious health concern [1], as it often tracks into adulthood [2] where it is associated with numerous cardiovascular and metabolic risk factors such as hypertension, type 2 diabetes or hyperlipidemia and even cardiovascular disease [3,4]. In addition, even at young age, overweight and obesity are related with various physical and psychological comorbidities. For instance, it has been found that overweight and obese children and adolescents often suffer from elevated blood pressure, dyslipidemia or disorders of glucose metabolism [5], and have a lower quality of life compared to healthy normal weight children [6].
The link between adiposity and the development of metabolic and cardiovascular diseases may be seen in obesity-related systemic inflammation [7,8]. Hypertrophy and hyperplasia of the adipose tissue as seen in obesity result in a dysfunction of the adipocytes [9], which increases inflammation and impairs hemostasis, glucose as well as lipid metabolism [7,8]. This is triggered by an alteration of the secretion of the adipokines adiponectin, leptin, retinol binding protein 4 (RBP4) and resistin as well as inflammatory markers such as interleukin 6 (IL-6), tumor necrosis factor-α (TNF-α) and C-reactive protein (CRP). For example, a decrease in adiponectin and an increase of RBP4 as often found in obese individuals may foster the development of insulin resistance. Furthermore, elevated levels of RBP4, IL-6 and TNF-α increase the inflammatory status by directly stimulating CRP synthesis in the liver [9].
In contrast, physical activity and/or weight-loss seem to have a positive impact on these mechanisms by improving the inflammatory status and reducing insulin resistance. However, data concerning these mechanisms in children are scarce and results from the existing studies have been inconsistent [9,10]. In addition, simultaneous measurements of adipokines, inflammatory markers, and cardiovascular risk factors of obese children before and after a short-term lifestyle intervention and at a long-term follow-up during late adolescence or adulthood have not been performed before.
Weight gain due to an increase in adipose tissue is the result of an imbalance between energy expenditure and energy intake. This balance can be influenced by both physical activity and caloric intake, which can be dependent on social, psychological and other behavioral factors. In addition, genes have been shown to play a fundamental role in the regulation of body weight [1,11]. Apart from very rare monogenetic disorders [12], a genetically determined higher risk for obesity can often be attributed to a polygenetic pattern involving different single nucleotide polymorphisms (SNP's). For instance, variations in the FTO-gene seem to have an effect on the development of early onset obesity. Likewise, a study by Frayling et al. has shown that a single-nucleotide polymorphism of the SNP rs9939609A allele is associated with an increased risk of overweight (odds ratio 1.18; 95% CI = 1.13 to 1.24) and obesity (odds ratio 1.31; 95% CI = 1.23 to 1.39), increasing the risk by 20-30%. Additionally, the A allele of the rs9939609 SNP has been found to be associated with an increased body mass index (BMI) in 7 year old children and to also determine obesity during puberty and beyond [13]. Furthermore loci associated with neuronal pathways (TMEM18, GNPDA2, SH2B1, NEGR1) have recently been identified to be associated with childhood obesity [14]. It has to be noted though that these genetic predispositions may only lead to an obesity phenotype in the presence of an obesogenic environment, and therefore this association may be modified by a lifestyle intervention [15,16].
Due to the tremendous short and long-term health consequences, current recommendations strongly encourage the treatment of childhood obesity, which may be performed in an outpatient or an inpatient setting (e.g. residential or weight-loss camps), or by a combination of both. However, the effectiveness of these types of programs remains uncertain [17]. In a recent review by Kelly and Kirschenbaum the average decrease in percent overweight within inpatient treatment across 11 studies was reported 23.9% from pre to post-intervention and 20.6% from pre-intervention to follow-up, whereas the effect on percent overweight was 8.5% and 8.9% for outpatient programs, respectively [18]. Within the EvAKuJ-study (Evaluation of obesity treatment in children and adolescents study) the short and long-term effects of different German childhood-obesity programs were assessed [19]. The authors reported that five out of 48 programs included took place in an inpatient setting (875 patients), whereas all others were carried out in an outpatient setting (1,041 patients). Children participating in inpatient programs achieved a mean reduction in BMI-SDS (BMI standard deviation score [20,21]) of -0.36 during the treatment and of -0.17 during the observational follow-up 1-2 years after termination of the treatment, whereas this was -0.18 and -0.21 for outpatient programs, respectively [19]. In summary, the results of inpatient versus outpatient programs are equivocal especially regarding long-term effectiveness.
Furthermore, as presented above, very few inpatient treatment programs have been evaluated, and these studies are heterogeneous regarding their study design and overall quality. For instance, the treatment duration ranges from 10 days to 10 months and only 29% of the studies included a follow-up period. The range in follow-up duration also varies dramatically (4 months to 4.6 years) and about half (46%) of the studies performed a follow-up after less than 1 year [18,22,23]. A study by Braet and van Winckel is the only one with a follow-up period of more than 3 years from the start of the intervention, however, they have not carried out blood analyses and the sample size of their inpatient treatment group was rather low [24].
These results emphasize that inpatient treatment might be the most effective strategy for children to loose body weight in the short-term, but that there is a substantial need for intervention studies with considerably longer duration of follow-up and a standardized protocol of the intervention and analyses. In addition, only very few studies have reported on the influence of lifestyle intervention in obese children whilst considering genetic predisposition [25-30].
To investigate the determinants for short, middle and long-term weight-loss and weight maintenance, a prospective cohort study involving overweight and obese children and adolescents (hereafter referred to as 'children') is being conducted, which includes a short-term inpatient weight-loss program complemented by a long-term observational follow-up over 10 years. Measurements include anthropometric, cardiometabolic and genetic parameters as well as assessment of physical activity and fitness, dietary habits and quality of life.
The associations between polymorphisms in adiposity-relevant genes (e.g. FTO, MC4R, TMEM-18) on the changes in BMI and BMI-SDS after a controlled lifestyle intervention (4 to 6 weeks) in overweight and obese children and adolescents.
The short (4 to 6 weeks), middle (6 to 12 months) and long-term (2, 5 and 10 years) effects of the intervention on the below-listed parameters and their associations with polymorphisms in adiposity-relevant genes (e.g. FTO, MC4R, TMEM-18):
• anthropometric parameters
• parameters of lipid and glucose metabolism
• adipokines and inflammatory markers
• physical fitness
• physical activity
• dietary behavior and intake
• health-related quality of life
Participants of the LOGIC-trial (Long-term effects of lifestyle intervention in Obesity and Genetic Influence in Children) are 6 to 19 year old overweight and obese children, who are referred to the rehabilitation center Klinik Schönischt in Berchtesgaden, Germany by their local pediatrician to have inpatient weight-loss treatment. The clinic is specialized on childhood obesity and about 200 children with the primary diagnosis overweight/obesity are being treated here annually.
Children are admitted to the clinic on a biweekly basis and recruited consecutively by scientists from the Department of Prevention, Rehabilitation and Sports Medicine, Technical University of Munich. In case they fulfill the inclusion criteria (see Table Table1),1), assent and informed consent for study participation are obtained from the children and their accompanying legal guardians.
The study is conducted according to the declaration of Helsinki (Seoul, 2008) and approved by the ethics committee of the Faculty of Medicine of the Technische Universität München, Germany (1354/05).
Recruitment for this collaborative study began in January 2006 with the aim to include a total of 1,500 participants by 2013. Figure Figure11 shows the flow chart of the recruitment and the measurement process. Examinations are performed at the start (Visit 1) and at the end of the intervention (generally after 4 to 6 weeks; Visit 2) at the clinic. Follow-up examinations are performed at 6 months (Visit 3), 1 year (Visit 4), 2 years (Visit 5), 5 years (Visit 6) and 10 years (Visit 7) after the start of the intervention by either local pediatricians or general practitioners (Figure (Figure11).
The rehabilitation clinic is primarily focused on inpatient treatment for childhood overweight and obesity which typically lasts for 4 to 6 weeks. The duration of the stay depends on health insurance allowance and the severity of obesity. Typically the children are referred to the clinic for 4 weeks and in case of severe obesity or comorbidities they have the opportunity to extend the program. The standardized multimodal program focuses on a calorie restricted balanced diet, an increase in physical activity and behavioral counseling. It is conducted by an interdisciplinary team of pediatricians, exercise physiologists, dieticians, psychologists and pedagogues according to German guidelines for inpatient weight-loss programs (AGA, Arbeitsgemeinschaft Adipositasim Kindes- und Jugendalter) [31].
The children are offered an optimized balanced diet prepared according to current guidelines (30%, 15% and 55% of the total energy content from fat, proteins and carbohydrates, respectively), with an allowed energy intake of 1,250-1,800 kcala per day, depending on height and sex (Table (Table2)2) [32]. The components of the intervention program are shown in Table Table3.3. In brief, the children are required to participate in theoretical and practical lessons on healthy eating, physical activity and behavior change skills based on the cognitive-behavioral theory. The exercise therapy consists of approximately 10 h of organised physical activity per week,b in addition to 6 hours of recreational exercise.
An overview of all measurements at the different time points (Visits 1-7) is presented in Table Table4.4. During the inpatient treatment, the physical examination is performed on the day of admission and on the day of discharge. Blood samples are taken on the third day after admission to the clinic and 3 days before discharge (except for DNA samples, which are taken only at baseline). Physical fitness testing is performed and questionnaires are filled in on the first weekend after admission to the clinic and 1 to 2 days before discharge. In case children extend the treatment, all examinations are being conducted after 6 weeks. Questionnaires are filled in without supervision.
Body height is measured barefoot to the nearest 0.5 cm by a rigid stadiometer. Body weight is measured with minimal clothing to the nearest 0.1 kg by a digital scale (Visit 1 and 2: Tanita BC-420 P MA Profi, Tanita Europe B.V., Hoofddorp, The Netherlands; Visits 3-7: calibrated scale). Waist circumference is measured on bare skin by tape to the nearest 0.1 cm midway between the lower rib margin and the iliac crest in standing position after normal exhalation with a non-stretchable tape measure. Blood pressure is measured at the right brachial artery in the fossa cubitalis after the children have been resting for 5 min in supine position by using a validated protocol [33]. Pubertal development is determined according to Marshall and Tanner [34,35]. Data on the medical history are documented including current medication and comorbidities (orthopedic complications, attention deficit (hyperactivity) disorders, thyroidal diseases, asthma, metabolic diseases, psychological diseases, acute diseases). All inpatient examinations and assessments are conducted by trained medical staff according to standardized procedures.
Blood sampling is performed following a 10 hour overnight fast. Samples are taken by venipuncture of an antecubital vein in either a sitting or lying position using vacuum tubes. Both plasma and serum samples are stored at -80°C until analyzed. The following parameters will be analyzed from serum: high density lipoprotein (HDL), low density lipoprotein (LDL), total cholesterol, triglycerides, glucose, proinsulin, insulin, uric acid, TSHbasal, adiponectin, leptin, RBP4, resistin, high sensitive CRP, IL-6 and TNF-α.
Genomic DNA for all subjects is stored at -20°C after isolation from EDTA blood following a standard protocol. In a first step several SNPs were selected from HapMap CEU data (release 21 phase II, dbSNP 125) including SNPs with minor allele frequencies > 5% in genes of interest for the phenotypes available (e.g. body weight, physical fitness, risk factor profile). In a first step, genotyping was performed using the MassARRAY system with iPLEX™ Gold chemistry (Sequenom, San Diego, CA, USA). The samples were analyzed in a matrix-assisted laser desorption ionisation time of flight mass spectrometer (MALDI TOF MS, BrukerDaltonik, Leipzig, Germany). Further analyses will be performed using state of the art genotyping methods.
Physical activity is assessed by a questionnaire and by pedometers. Cardiovascular fitness is assessed by both cycle ergometry and a 6-Minutes running test.
The physical activity questionnaire has been adapted to the MOMO questionnaire, which has been previously validated [36,37]. Items of the questionnaire include volume, frequency, duration and intensity of school, sports clubs and/or leisure time activities, motivation to be physically active [38] as well as questions on sedentary time (screen time and homework). Between 2008 and 2010 all study participants were asked to wear a pedometer (OMRON Walking Style Pro) all day for 2 to 4 weeks during their inpatient stay at the clinic. They also completed a physical activity diary for these days.
Exercise testing is performed stepwise on a cycle ergometer (Jaeger ERGOSTESTER 900) to the participants' volitional exhaustion. Absolute or relative exercise capacity (Watt, Watt/kg) is used as a measure of cardiovascular fitness. Since 2008 the study participants have been taking part in a 6 min running test. For this test, which takes place on a straight outdoor sports ground, the children are asked to walk or run as far as possible within 6 min. The covered distance is documented in metres.
For the assessment of dietary intake, a food frequency recall is used, which has been validated previously in a survey [39].
To assess quality of life, the validated German KINDLR-questionnaire [40,41] with six dimensions ("physical well-being", "emotional well-being", "self-esteem", "friends", "family" and "everyday functioning (school)") is being used. The subscales of these six dimensions are combined to a total score. Furthermore, an additional sub-scale, developed specifically to assess the quality of life of overweight children, is being used, which consists of a filter question and six items. The reliability and validity of this questionnaire have been described elsewhere [41].
In addition, a standardized questionnaire that is supposed to be completed by the parents on the day of admission is being used to obtain demographic information as well as obesity-related health history of first degree family members.
Prior to the first follow-up examination, which takes place 6 months after the start of the program (Visit 3), study investigators contact the general practitioners by telephone to inform them about the study procedures and to obtain agreement on carrying out the upcoming follow-up examinations. The general practitioners are asked to complete and return a standardized examination sheet including anthropometric measurements (body weight, height and waist circumference), blood pressure and Tanner stage as well as comorbidities and the current use of medication.
In addition, study investigators contact the children prior to each visit (6 months, 1 year and 2 years after the start of the intervention) to remind them of the upcoming examination and to enquire about possible address changes. The children are requested to complete the questionnaires, previously sent by post, and to return them using the provided prepaid envelope as well as to visit their general practitioner for the follow-up examination. If both the questionnaires and the examination sheet are returned to the study centre, the children will receive an allowance of 10 Euros.
For the 5 and 10 year follow-up examinations, the children are invited to visit the study centre at the Department of Prevention, Rehabilitation and Sports Medicine, Technical University of Munich, where the same measurements as at baseline (Visit 1) are planned to be obtained (except for DNA and family history). Children, who are not able to visit the study centre, have blood samples taken by their general practitioner in addition to the basic examination as carried out for the previous follow-up examinations. The blood parameters analysed are fasting HDL, LDL, total cholesterol, triglycerides and glucose. The allowance for each of this visit is 20 Euros.
At all visits, children whose documents have not been returned to the study center are contacted by telephone, repeatedly if necessary, in order to collect the missing documents. If children wish to withdraw from the study in spite of efforts to motivate them to continue participating, study investigators fill out an official drop out sheet.
Associations between polymorphisms in adiposity-relevant genes (FTO, MC4R, TMEM-18) and changes in BMI(-SDS) from the start to the end of the intervention, will be assessed using analysis of covariance (ANCOVA) models comparing mean changes in BMI(-SDS) between the two groups of homozygous and the group of heterozygous children adjusted for age, sex and baseline weight. A two-sided level of significance of α = 0.05 will be used. For pairwise group comparisons, two-sample t-tests will be conducted using a Bonferroni-adjusted level of significance of α* = 0.0167.
Middle and long-term associations between genes and measures of interest such as weight change, physical fitness and physical activity will analogously be analysed in an explorative manner. Linear regression models including all relevant genes plus baseline weight, age and sex will be fit into estimate predictive models for the expected short and long-term weight changes. Predictive accuracy of the models and most relevant genes will be assessed using re-sampling methods (e.g. bootstrap) [42]. To estimate the influence of genes on relevant measures over time, a mixed model will be fit to account for multiple measures in the same participants. Missing values will be replaced using multiple imputation methods based on observed values with varying assumptions. Differences in the results obtained by different imputation strategies will be reported and discussed.
With a sample size of 1,500 children the study is sufficiently powered to detect significant differences in all pairwise comparisons between allele groups on an adjusted two-sided level of significance of α* = 0.0167, if the true difference in means is at least half of the common standard deviation translating to an effect size of 0.5 (power > 90% for each pairwise comparison). The sample size calculation is based on the assumption that the distribution of alleles leading to the smallest subgroups will be 70%, 25% and 5%, hence the smallest sample sizes for pairwise comparisons will be 375 versus 75 children. Sample size estimation was conducted for a two-sample t-test with unequal group sizes using the software nQuery (Version 7.0).
This manuscript provides an outline of the rationale and the design of the LOGIC-trial, which is the first study that evaluates the short, middle and long-term effects of an inpatient weight-loss program in association with genetic factors in a large group of children and adolescents (aimed sample size n = 1,500) and includes follow-up measurements over 10 years. Hence, this study will allow the investigation of important determinants of successful weight-loss, particularly the role of a specific genetic predisposition. To achieve this, a large amount of data is being collected, on anthropometry, blood parameters (adipokines and inflammatory markers), physical fitness, physical activity and quality of life.
To our knowledge, only 24 evaluated inpatient programmes have been published, of which merely 14 carried out follow-up assessments. In all studies but one the follow-up periods lasted no longer than three years. No study has ever carried out follow-up measurements after more than five years following an inpatient weight-loss program [18,22-24]. Therefore, our study is unique particularly regarding the 5 and 10 year follow-up measurements and allows investigating the tracking of the effects of an inpatient lifestyle intervention from childhood to adolescence and adulthood. In addition, the large sample size of 1,500 children allows a thorough investigation of the genetic questions of interest. The question of genetic predisposition is particularly interesting regarding obesity and weight change, as obesity is considered as a polygenic syndrome with various SNPs involved. To date, however, the impact of the SNP's on the individual responses to obesity treatment in children is still unclear. The studies that have shown an influence of genetic factors on changes in body weight induced by a lifestyle intervention in children [25-30] had relatively small sample sizes (n = 236 to n = 519) and have shown inconsistent results. A clear advantage of the LOGIC-trial protocol is the inclusion of adipokines and inflammatory markers, as well as objective measures of physical fitness, which will allow investigations of the associations between changes in body weight, inflammation and physical fitness. These investigations are of particular relevance in light of potentially important links between these parameters as indicated by a recent review [7]. Some studies have shown relevant associations between adipokines and weight-loss induced by lifestyle interventions [43-46], whereas particularly the results concerning the associations between adipokines and physical fitness are equivocal. This can be explained by the small sample sizes and different outpatient study settings [47-51]. A further strength of the LOGIC-trial is that all anthropometrical parameters are taken by either a nurse or a general practitioner. This avoids the underestimation of body weight that is often observed in self-reports [52]. The inpatient setting is standardised in that participants are living in a controlled environment with similar dietary and exercise conditions and intervention. Such a controlled setting is particularly important for the investigation of the influence of genetic factors, which can be strongly confounded by environmental conditions [15].
Our study has a few limitations, which cannot be completely avoided in this real-life setting. This is an observational study and not a randomized controlled trial. In a randomized design with a 10 year follow-up time it would be ethically questionable to randomize children into an inpatient weight-loss programme and a control group, as the children from the control group would not be allowed to take part in the lifestyle intervention during that time. In addition, the primary intention of this study is to investigate the inter-individual variability of the effects of the intervention depending on the children's genotypes, which does not necessarily require a control group. For cross-sectional analyses, we use an age-matched sample of normal weight children of a school-based intervention study [53] as well a cohort of young athletes, who are recruited at the Department of Prevention, Rehabilitation and Sports Medicine, Technical University of Munich.
As we recruit a selected cohort of children who take part in a specialized obesity program it has to be considered that data from clinical samples may not be representative for general populations. Furthermore, although we do have objective physical activity measurements during the intervention, long-term physical activity is assessed by questionnaires. It has been planned this way as we require a standardised physical activity assessment method that can be carried out by all participants for every follow-up measurement during this 10 year time period. Considering the inclusion of 1,500 children and in total seven measurement time points, objective physical activity measurements would have been almost impossible. Similar to the physical activity, nutritional behavior and intake is assessed by questionnaire. Again, more objective measurements such as dietary records would have been optimal but logistically difficult to integrate. In order to maintain high the compliance of the participants we tried to develop and carry out follow-up examinations that are valid, practical and not too time consuming. Therefore we are not using a detailed food frequency questionnaire.
In summary, this is the first lifestyle intervention study with a detailed assessment of short, middle and long-term weight changes, physical fitness, cardiometabolic risk factors including both inflammatory markers and adipokines in a large cohort of overweight and obese children. Apart from elucidating the short-term effects of this supervised weight-loss program, this study will provide the outstanding opportunity to investigate the tracking of the immediate effects of a lifestyle intervention on body weight and the cardiometabolic risk profile from childhood into adolescence and adulthood under consideration of the influence of genetic predisposition. This will contribute to a better understanding of inter-individual differences in the regulation of body weight and thus may lead to an optimization of personalized treatment strategies for childhood obesity.
The authors declare that they have no competing interests.
MR has drafted the manuscript. DW has been substantially involved in writing the manuscript. Both are active investigators of the study on site as well as in the analysis center. MH, BW, MS and HL have conducted the study design. In addition, BW was responsible for the design and implementation of the genetic analysis in the study. HL has been coordinator at the Kinik Schönsicht. MH, MS, HL, MR and DW have coordinated the study. MH is senior principle investigator. BH has been in charge of the statistical analyses. All authors have critically read and approved the final manuscript. The trial has been registered under clinicaltrials.gov NCT01067157.
aBased on clinic internal considerations this has been changed from 1,200-1,800 to 1,250-1,800 kcal per day in the year 2010.
bBased on clinic internal considerations this has been changed from 11 to 10 h per day in the year 2011.
The pre-publication history for this paper can be accessed here:
The study is funded by the non-profit organization Else Kröner-Fresenius-Stiftung, Bad Homburg, Germany and the German statutory pension insurance scheme, Landshut, Germany. We are also grateful for the support of the staff of the Klinik Schönsicht in Berchtesgaden as well as both the children and their parents for their participation in the LOGIC-trial. Furthermore we thank the collaboration partners of the project: Prof. Dr. med. W. Koenig' Department of Internal Medicine II-Cardiology, University of Ulm Medical Center, Ulm, Germany (analyses of adipokines and inflammatory markers), PD Dr. Thomas Illig, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany and Univ.-Prof. Dr. med. Hans Hauner, Else Kröner Fresenius Centre for Nutritional Medicine, Technical University of Munich, Munich, Germany (DNA-analyses) as well as Prof. Dr. Renate Oberhoffer, Institute of Public Health Research, Technical University Munich, Munich, Germany (follow-up care).
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


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September 03, 2009
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2013-06-23 at 3:56:48 am #2107
The Success of Europe's While-You-Wait Inkjet Refilling Business
Over The past few years, inkjet printing has become one of the fastest growing industries in the world. This growth has been spurred by the increased penetration of PCs in homes and businesses as well as the availability of low-cost colour printers. More recently, the explosion in digital camera usage is also fuelling the growth in the output market for vendors of inkjet printers, media, and cartridges.
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* Post was edited: 2004-09-16 10:07:00


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Surrender in the War on Drugs
Law enforcement officials tell us that the majority of serious crimes inAmerica are committed by drug addicts trying to finance their illicit habits. For decades we have tried to deal with this problem by incarcerating drug addicts and cutting off the supply of illegal drugs. Both campaigns have been miserable failures. It's time that we face reality: WE LOST THE WAR ON DRUGS. And there's nothing we can do to win it. So let's SURRENDER. Make all drugs legal inAmerica , if used by an adult.
The result of legalization of drugs would be a major drop in serious crime, especially murder, armed robbery, and burglary. There would also be a decline in the corruption of public officials, who are bribed with vast amounts of money because illegal drugs are so immensely profitable. We would save hundreds of billions of dollars which are being WASTED arresting, prosecuting, and incarcerating drug addicts.
Opponents of legalized drugs argue that it might result in increased drug addiction. Perhaps so. But the fact is that millions of people have addictive personalities. If they aren't using cocaine or heroin, they are probably going to be addicted to another drug, such as alcohol, which can be even worse. We can create drug counseling programs and hope to cure addicts, but realistically we are going to fail with millions of people. We need to cut our losses and stop fighting a futile battle against illegal drugs.
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