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Life Technologies (NASDAQ:LIFE)
Q3 2012 Earnings Call
November 01, 2012 4:30 pm ET
Carol A. Cox - Senior Vice President of External Affairs & Corporate Communications
Gregory T. Lucier - Chairman and Chief Executive Officer
David F. Hoffmeister - Chief Financial Officer and Senior Vice President
Mark P. Stevenson - President and Chief Operating Officer
Jonathan P. Groberg - Macquarie Research
Amanda Murphy - William Blair & Company L.L.C., Research Division
Tycho W. Peterson - JP Morgan Chase & Co, Research Division
William R. Quirk - Piper Jaffray Companies, Research Division
Charles Anthony Butler - Barclays Capital, Research Division
Derik De Bruin - BofA Merrill Lynch, Research Division
Jeffrey T. Elliott - Robert W. Baird & Co. Incorporated, Research Division
Daniel Brennan - Morgan Stanley, Research Division
Shaun Rodriguez - Cowen and Company, LLC, Research Division
Daniel L. Leonard - Leerink Swann LLC, Research Division
Isaac Ro - Goldman Sachs Group Inc., Research Division
Vijay Kumar - ISI Group Inc., Research Division
Vamil Divan - Crédit Suisse AG, Research Division
Bryan Brokmeier - Maxim Group LLC, Research Division
Peter Lawson - Mizuho Securities USA Inc., Research Division
Good day, ladies and gentlemen, and welcome to the Life Technologies Corporation Third Quarter 2012 Earnings Conference Call. [Operator Instructions] As a reminder, this program is being recorded. I would now like to introduce your host for today's program, Ms. Carol Cox, Head of Investor Relations. Please go ahead.
Carol A. Cox
Thank you, Jonathan. Good afternoon, everyone. Welcome to Life Technologies Third Quarter 2012 Earnings Conference Call. We issued our press release today a little after 1 p.m. Pacific Time. It posted it on our website at lifetechnologies.com, and we'll be filing it on Form 8-K with the Securities and Exchange Commission. We've also posted a deck of slides to accompany the webcast today, which may be found on the Events and Presentations section of our Investor Relations website, along with our other additional earnings materials.
Joining me on today's call are Greg Lucier, our Chairman and CEO; and Dave Hoffmeister, our Chief Financial Officer. Mark Stevenson, our Chief Operating Officer, will also be available during the Q&A portion of the call to answer any questions. If you've not had a chance to review the earnings release, it can be found on our website, at lifetechnologies.com.
I would like to remind our listeners today that our discussion will include forward-looking statements including, but not limited to, statements about future expectations, plans and prospects for the company. We believe these statements are based on reasonable assumptions, but actual results may differ materially from those indicated. Important factors, which could cause actual results to differ materially from those in the forward-looking statements, are detailed in our filings with the Securities and Exchange Commission. It is our intent that these forward-looking statements be protected under the Safe Harbor created by the Private Securities Litigation Reform Act of 1995.
Additionally, we will be discussing GAAP and non-GAAP measures. A full reconciliation of the GAAP -- excuse me, the non-GAAP measures to GAAP can be found in today's press release or on our website.
And with that, I will hand the call over to Greg.
Gregory T. Lucier
Thanks, Carol, and thank you to everyone who's joining us today as we provide an overview of our third quarter results and expectations for the remainder of the year. At a high level, we continue to gain momentum, as we expand into higher growth markets through partnerships, acquisitions and internal development.
During the quarter, we entered into strategic business partnerships for companion diagnostics, completed the foundation of our Medical Sciences business with tuck-in acquisitions of Navigenics, Pinpoint and Compendia and acquired distributors in China and Chile to continue to extend our footprint in emerging markets.
We achieved important milestones with several highly anticipated product launches, including the Ion Proton System, a platform whose speed, ease-of-use and affordability will democratize genome sequencing, as well as our Pervenio Lung test, the first-of-its-kind molecular test to identify early-stage lung cancer patients, who are at a high risk of reoccurrence following surgery. I'm extremely pleased with the progress of our management team is making across our business platforms and geographies. We are moving fast in a disciplined way.
Now let me turn to the results. We finished the quarter ahead of our expectations as continued strength across several our businesses contributed to results. Revenue for the quarter came in higher than expected at $911 million, as significantly increased sales in our Ion Torrent platform driven by Ion Proton System sales and continued strong demand for the Ion PGM, as well as growth in Forensics and Research Consumables drove the 1.4% increase.
Recall that this growth rate includes overcoming headwinds from the decline in sales of our SOLiD 5500 instruments. Our non-GAAP earnings per share came in at $0.92, ahead of our guidance due to slightly higher sales, higher-than-forecasted gross and operating margins and the benefit of a lower share count, as we continue to aggressively repurchase shares. Overall, our end markets remain largely in line with our expectations.
In the U.S. and Europe, we continue to see a cautious but stable environment. Last quarter, we guided to growth in Europe of low single digits, which is generally what we saw in the third quarter with growth coming in at 2%. We saw a strength in Asia-Pacific and Japan, as well as our emerging markets where we continue to expand our operations.
China continues to be a growth market for us, as we continue to invest there on multiple fronts, including expanding our operational capabilities. We completed the acquisition of Genewindows, Life's distributor, covering mainly the Invitrogen brand reagent portfolio in South and West China. This acquisition complements our go-direct strategy for consumables in mainland China. We also expanded our footprint with the completion of our state-of-the-art facility in Beijing, where we will manufacture advanced DNA testing solutions locally to help Forensics labs and law enforcement agencies solve crimes more cost effectively.
Finally, we entered into a strategic partnership with Sino Biological, a leading Chinese biotechnology company and one of the largest cDNA recombinant protein and antibody product manufacturers and suppliers to biomedical and pharmaceutical research in the world. They have developed the capability to produce over 1,000 new recombinant protein bolts [ph] per year in house and have commercialized more than 10,000 products. Through this partnership, we will distribute Sino Biological's broad portfolio of products and jointly develop new proteomic products for additional obligations.
During the quarter, we continued to execute on our development pipeline with product launches across several of our businesses, including the Ion Proton System, the PI Chip and the Pervenio lung cancer test I mentioned earlier. In addition to these launches in our Genetic Analysis and Medical Sciences businesses, we also launched GlobalFiler and GlobalFiler Express in our Forensics business.
These 2 new DNA kits are revolutionizing how crime labs perform forensic testing around the world, making it faster, easier and cheaper to process DNA samples. By increasing the number of genetic markers by over 30%, GlobalFiler delivers the ability to recover significantly more information from forensic samples and increases discrimination power, resulting in faster and more powerful comparisons of forensic data to resolve crimes.
To date, 44 countries have now implemented criminal offender DNA database programs, with a combined offender sample pool of 40 million and growing. On our last quarterly call, Ronnie Andrews joined us to talk about his vision for our Medical Sciences business. Since that time, we've continued to make progress.
Earlier in October, we announced our acquisition of Compendia Bioscience, which will enable deeper engagement with an established customer base at leading pharmaceutical companies and will position Life as a partner of choice for drug and companion diagnostic development. Coupled with Navigenics and Pinpoint Genomics, tuck-in acquisitions in July, Compendia completes the foundation of our oncology strategy and positions Life to drive personalized medicine.
In combining these assets, we are now able to extend a full range of clinical capabilities by developing high-value, proprietary content design and validation through the CLIA lab, delivering interpretation through informatics and ultimately impacting clinical insights through our physician portal. Compendia's oncology workflow can also be incorporated with the Ion Reporter software to enable our Ion customers with robust bioinformatics solutions for early phase clinical research.
In addition to acquisitions, we entered into 2 partnerships that will help us build diagnostic content. We entered into our second agreement with Bristol-Myers Squibb for current and future companion diagnostic projects, covering an initial project for oncology and providing a long-term partnership across a potentially broad range of life instrument platforms and a wide range of therapeutic areas.
The pharmaceutical industry is increasingly turning its focus to discovering and delivering targeted personalized medications. As more and more targets -- targeted drugs come on to the market in the next decade, there will be a growing need for diagnostics that can help predict which patients will benefit from which drugs. For oncology alone, hundreds of agents are currently in clinical trials, and we can see an extremely strong market opportunity for the development of companion diagnostics.
We're also working to bring next-generation sequencing into the clinical market and recently signed a nonexclusive license and supply agreement with VelaDx to develop clinical diagnostic tests on Ion PGM for oncology and virology. VelaDx is a privately funded company, led by management team with extensive experience in the pharmaceutical and diagnostic arenas. Under the terms of the agreement, VelaDx will utilize the PGM platform with their Sentosa workflow and their menu of molecular diagnostic tests. They will pursue FDA approval for their systems and kits, which are already in conformance with CE IVD regulations.
The success of the clinical PGM platform, as is the case for most diagnostic platforms, will rely in part on the existence of a menu of tests that have high value in the market. We continue to seek our partners who are interested in helping us ensure that such a menu exists in multiple areas of clinical importance.
Progress across our Ion semiconductor sequencing platform accelerated significantly during the quarter. We made improvements to the PGM and AmpliSeq product lines, including the launch of a 400-base pair sequencing kit and Torrent software, launched our new Ion Proton system and introduced several new additions to the technology road map, including Avalanche, an emulsion-free template preparation chemistry that will work on all Ion platforms and also allows us to bring a third chip to the Proton series, which we are now calling the PIII chip.
We believe the Proton system is a real game changer as it truly opens up the market to affordable clinical exomes and genomes. The PIII chip brings with it new low cost and will make routine genome testing ordinary.
In mid-September, we hosted our first annual Ion World Customer Conference, which was a resounding success, with over 10 customer talks characterizing our competitive advantages and 450 customers in attendance providing positive feedback and indicating an interest in the Ion platform. The road map we presented at Ion World shows that semiconductor sequencing technology continues to scale in every respect, and the scientists who shared their work at the event confirmed the system's relentless performance gains.
Ion Torrent has emerged as the most outstanding value in sequencing. In just less than 2 years, read-length has gone from 100 to 400 base pairs and accuracy has improved from Q17 to Q30. Over the same period, the per-run throughput of semiconductor sequencing technology has increased a thousandfold, from 10 mega bases to 10 giga bases, delivering an approximately 5 hundredfold reduction in the sequencing cost per base to the user.
These improvements now enable any sequencing application, from targeted resequencing and microbial sequencing, to exome sequencing and transcriptome sequencing and many others. Given today's limited capital budgets, we are making it even easier for scientists to make a long-term investment in a technology that will outperform their legacy system today and scale to exponentially greater throughput over time.
We began shipping our Ion Proton system and the PI chip in September. We shipped over 100 systems in the third quarter. We are extremely pleased with the level of customer interest. The latent demand for Proton is more significant than we originally anticipated. The overall cost of the capital purchase, the ongoing service costs and run costs of traditional NGS instruments have significantly limited the number of research and clinical labs from participating in these markets directly.
We are also receiving positive feedback from our early customers as they get up and running on Proton system. Several of our customers will be presenting data publicly over the next several weeks. These customers are getting over 10 giga bases in 2- to 3-hour runs, with 80 million reads, which is at the high end of the range we communicated and has a fourfold advantage over other bench top sequencers.
Proton, using the PI chip, is the only bench top sequencer enabling whole exome and whole transcriptome analysis today. And with the PII chip, it will enable whole genome analysis. Enabling these speeds will make the Proton system transformational for medicine, hospitals and testing laboratories and will truly democratize genome sequencing and bring it into the routine clinical testing.
At Ion World, we announced we would be introducing 2 new automated templates preparation instruments, the Ion OneTouch 2 System and the Ion Chef System. The Ion OneTouch 2 system is ideal for labs with a Proton and media throughput requirements, while the Ion Chef system is ideal for labs with any level of molecular biology expertise or for labs with high throughput requirements. It automates the upfront sequencing workflow, going from library to loaded chips with just minutes of hands-on time and it's scheduled to ship in the first half of next year. Ion Chef further simplifies sample prep workflow and offers twice the productivity. Designed to support multiple Ion platforms, it can process either 2 PGM chips or 2 Proton chips per run with minutes of hands-on time.
During the quarter, our business continued to generate strong free cash flow of $177 million. At the beginning of the year, we communicated our commitment to a balanced capital deployment approach where 50% of our available free cash flow would be returned to shareholders. To that end, during the third quarter, we spent an additional $208 million to repurchase shares, bringing our year-to-date total spend on share repurchases to $535 million, more than exceeding that goal.
We have an additional $612 million remaining under our $750 million share repurchase program. The market dynamics we saw in the third quarter were largely as we expected with strong growth in the emerging markets and slower growth in mature markets like the United States and Europe. We continue to see the broader macro slowdown negatively affecting our European results, and in the U.S., we are now seeing some pullback in spending, as awareness of potential cuts to the NIH become more widespread.
While we have remain optimistic that Congress and the President will do the responsible thing and reach a bipartisan deal to avoid the fiscal cliff, we are also prepared if they don't. The main point is that in this period of uncertainty, we, like others in this industry, have limited visibility to what impacts political decisions will have on the purchasing patterns of our U.S. research customers.
Based on these dynamics, we expect our organic revenue growth in 2012 to be at 2% and could be slightly below that level if uncertainty around a debt deal increases in the U.S. market between now and the end of the fourth quarter. We continue to look for ways to reduce our operating costs including pulling back in some areas of discretionary spending in the fourth quarter.
Assuming the benefit of these spending reductions, a potential pickup from improved currency rates and the lower share count resulting from capital allocation commitments we are executing on, we are increasing the low end of our EPS range by $0.05 to $3.95 and maintaining the top end of the range at $4. We continue to do our best to navigate through these uncertain times and remain committed to further diversifying our end market exposure. We are continuing to make investments in markets where we believe we have the growth opportunities that will make us increasingly more competitive and vibrant in 2013 and 2014.
And with that, I'll turn it over to David.
David F. Hoffmeister
Thanks, Greg. Good afternoon, everyone. In my remarks today, I will provide an overview of our results for the third quarter and a more detailed commentary around our expectations for the fourth quarter and the full year.
As Greg mentioned, we delivered third quarter revenue and earnings growth ahead of our internal expectations. Revenues of $911 million grew 1.4% year-over-year, excluding the impact of currency and were above the high end of the range of $900 million to $910 million we provided in July.
Our non-GAAP earnings per share came in at $0.92, ahead of the previous guidance range of $0.87 to $0.90, primarily due to a solid operational performance and the benefit of a lower share count as we continued to repurchase shares. Our free cash flow for the quarter totaled $177 million. At a more detailed level, revenue, excluding currency by region, was as follows: the Americas declined 1%, Europe grew 2%, Asia-Pacific grew 10%, and Japan grew 4%.
Taking a closer look at our business group results for the quarter. Research Consumables revenue decreased 3% to $384 million. Excluding currency, revenue increased 1% over the same period last year, driven by growth in our cell culture products, sample prep products and bench top instruments. Revenue for Genetic Analysis decreased 1% to $353 million for the third quarter compared to prior year.
Excluding currency, revenue increased by 2%. The growth was primarily due to a significant step up in Ion Torrent instrument sales, as we launched the Ion Proton System late in September, and continued strong demand for the Ion PGM instruments and consumables. Offsetting some of this revenue growth was the expected headwind from SOLiD instrument sales and the decline in CE instruments, primarily due to one-time orders in the prior year quarter and the timing of some sales.
While we had expected qPCR royalties to decline by approximately $7 million to $8 million year-over-year, the actual decrease was about $3 million as our team was able to offset declines with additional royalty licensing programs. Applied Sciences revenue was flat, at $174 million for the third quarter compared to prior year. Excluding currency, Applied Sciences grew 3%. The increase was driven primarily by higher forensic kit sales and qPCR Applied Sciences instruments.
This increase was partially offset by lower sales of CE instruments due to one-time orders in the prior year quarter and an expected decline in BioProduction sales, which tend to fluctuate quarter-to-quarter. Gross margin decreased 50 basis points to 65.6% compared to prior year, driven by the impact of unfavorable currency and an increase in Ion Torrent instruments, partially offset by lower SOLiD 5500 instrument sales.
On a sequential basis, gross margin was in line with the second quarter. Operating expenses of $343 million were $3 million higher on a year-over-year basis, principally due to our continued investment in Greater China and Medical Sciences. On a sequential basis, operating expenses were down as expected, due to our continued management of discretionary costs.
Our operating profit totaled $255 million, a decrease of 7% over prior year. Third quarter operating margin was 28%, representing a decrease of 140 basis points. The decrease from the prior year was the result of lower gross margins and the higher operating expenses that I just discussed.
In terms of other income line items, we had $400,000 of interest income, a loss of $2.8 million on foreign exchange and other items and interest expense of $29 million. Our tax rate for the quarter was 27.3%, slightly lower than the second quarter rate of 27.6%.
Our diluted share count for the quarter was 177.3 million, a decrease of 9.6 million over the prior year, as we continued to repurchase shares as part of our overall capital deployment strategy. In Q3, we repurchased approximately 4.4 million shares for $208 million, and now have $612 million remaining on our current share repurchase authorization.
Moving on to the balance sheet and cash flow statements. We are ending -- our ending cash and short-term investments were $299 million. This compares to last quarter's balance of $303 million. Cash from operating activities was $197 million. Capital expenditures were $20 million, and free cash flow was $177 million.
Return on invested capital was approximately 9% for the quarter. Our ending debt as of September 30 was approximately $2.5 billion. This balance is made up of our senior notes of $2.3 billion plus some short-term debt. We expect to end the year within our target leverage range of 2.0x to 2.5x EBITDA.
Now let me take a moment and talk about our outlook for the rest of 2012. As Greg said, we expect our revenue growth, excluding currency for the year, to be approximately 2%. Our intention is to offset any additional macroeconomic pressures through continued reductions in discretionary spending. As a result of these initiatives, we continued to expect our operating margin to expand in a range of 25 to 50 basis points for the year.
Given our additional share repurchases in Q3, we're now expecting our full year share count to be in the range of 179 million to 180 million, down from the 180 million to 182 million we'd previously guided to. We expect our tax rate to be about 27.5% for the full year, assuming the R&D tax credit is reinstated in Q4.
Taking into account these factors, we are increasing the lower end of our EPS range by $0.05 to $3.95 and maintaining the top end of the range at $4. And now let me provide additional color on the fourth quarter. Gross margins are expected to be up year-over-year, largely due to manufacturing productivity related to savings in material cost and lower inventory write-offs than last year, partially offset by lower royalty revenue and higher instrument sales.
Our operating expenses are expected to be up year-over-year, as we continue to invest in Medical Sciences, partially offset by a reduction in discretionary spending. Currency has fluctuated considerably from month-to-month and continues to be highly variable.
Net of the hedge benefit, currency at September month-end rates could negatively impact revenue by $11 million and EPS by a couple of pennies for the fourth quarter. Given these assumptions, we expect Q4 EPS to be in the range of $1.08 to $1.13. Those of you who saw our press release may have noticed that we had a section in there about subsequent litigation, and let me comment on that.
About an hour prior to our earnings call, we received an unfavorable verdict in our litigation with Enzo Biochem relating to CE sequencing projects during the period 1998 to 2004. The relevant patent expired in 2004 prior to the acquisition of AB, so the verdict does not have any impact on our CE business going forward. The jury ruled that Life Technologies had infringed Enzo's intellectual property relating to reagent sales and gave a verdict in the amount of $48.5 million in favor of Enzo.
As a result of today's verdict, we will record a GAAP-only expense of $48.5 million for the third quarter ended September 30, 2012. This will result in a reduction of GAAP net income of approximately $31.5 million, or $0.18 per diluted share. The current financial tables in our press release filed today do not reflect this expense, but we intend to file updated financial tables in an amended Form 8-K in the next 2 business days.
As you recall, we had a similar situation with our litigation against Promega earlier this year, where the jury ruled against us. We appealed, and subsequently, the verdict was overruled. While we can't predict the outcome of litigation, we strongly disagree with the Enzo verdict and intend to vigorously challenge it in the trial court and on appeal.
And with that, I'll hand the call back over to Carol.
Carol A. Cox
Great. Thanks, David. And, Jonathan, we'll open up the call now to questions and answers. [Operator Instructions]
Question-and-Answer Session
[Operator Instructions] Our first question comes from the line of Jon Groberg from Macquarie.
Jonathan P. Groberg - Macquarie Research
Greg, if I can just focus on the top line for a second, you mentioned a lot of the -- obviously the uncertainty out there and some of the headwinds. If we think about -- one of the issues this year was obviously the fall off in SOLiD. Can you maybe talk a little bit how you're feeling with respect to Ion? You made a number of announcements obviously, that you went over again on the call here, but maybe what you're seeing in terms of Proton demand? A little -- maybe any more detail you're willing to provide and maybe how you think that translates into early next year? And then maybe also there's been a lot of questions around emerging markets. If you could maybe just kind of comment a little bit around what you're seeing maybe in China and emerging markets.
Gregory T. Lucier
You bet. Thanks, Jon, for the question. We're very positive of the Ion Torrent franchise. You've seen, just in the last 90 days, pardon the pun, a torrent of new product launches with the PI chip, the announcement of the PIII chip, entirely new sample preparation instruments, as well as chemistries, and an increasing uptake of the AmpliSeq panels being used in translational research. So we're very pleased with how this franchise just continues to grow, and it's tracking the original deal model when we acquired Ion Torrent about 2 years ago. So as we look to 2013, we see another, just phenomenal year of growth of this franchise and because of these new product launches, because of a build out of more focused sales teams now to call on laboratories that are doing translational research, we think that we'll have, again, another just banner year of sales growth. Maybe turning our attention then to your second question of emerging markets. I think you can see our strategy playing out is that as we see this research reagents and instruments industry mature and consolidate, our goal is to vertically integrate ever more forward into our distributors in countries where we're seeing really strong growth. Every time that we do that, we can have more direct conversations with scientists. We broaden the available products we sell, and we just have faster growth, and so we're staying the course. We like our strategy. We're investing where the growth is, and we think that ultimately this industry centers around just a couple of big players, and we're certainly going to be one of them.
Our next question comes from the line of Amanda Murphy from JPMorgan -- I'm sorry, from William Blair.
Amanda Murphy - William Blair & Company L.L.C., Research Division
[Audio Gap]
business, so I think this is discussed last quarter as well, that you've been running at that 1% run rate. So -- and obviously, there's uncertainties around funding, but how are you thinking about that, that business next year and longer term? Is it fair to say there's some pent up demand there, or do you think you can drive that growth back up to what is a more normal run rate?
Gregory T. Lucier
I'm sorry, Amanda, your -- the first part of your question got cut off. So if you could repeat the first part?
Amanda Murphy - William Blair & Company L.L.C., Research Division
I'm sorry. I was just asking about the underlying consumables business and just the growth rates there. Obviously, there's a lot of uncertainty for the rest of this year, but I was curious how you're thinking about that for the longer term. It's been running at that 1% sort of growth rate. Is this something where we can think about pent-up demand next year, when we're passed all the uncertainties? Or what's the right sustainable growth rate for just as a base underlying consumables business?
Gregory T. Lucier
You bet. So let's look at that question maybe by geographical split. So in Europe, you have seen the industry, just due to the external market demand ease down to that lower single digits, and we think, at least in the next year, that's about where it's going to remain. If we go over to Asia and the emerging markets like Middle East and South America, we're seeing much more robust growth for those consumables, and so we think actually that continues to grow at a nice pace in 2013. So the real question mark then of your question is the United States and what happens. And clearly we've seen this moderation of demand in 2012 due to all the uncertainties coming out of Washington, D.C. Look, our hope is that this thing settles out here between now and hopefully the beginning of the year and that we enter into 2013 in the United States with more reasonable, consistent demand going forward. Certainly, that's what all the universities, research institutes want. And at least we're hopeful that smart minds and mature minds prevail in Washington to bring about some certainty here in government funding. So we'll have to see, but our hope here is that the United States returns to a little bit better growth, in which case I think you'll see us move up from that 1% growth that we've experienced this year.
Our next question comes from the line of Tycho Peterson from JPMorgan.
Tycho W. Peterson - JP Morgan Chase & Co, Research Division
As we think about guidance and what you're implying here for the fourth quarter, you are calling for a nice acceleration then, Greg, you talked about the backdrop getting a little bit more difficult heading into the fiscal cliff. So can you talk about what gives you conviction in maybe 4% growth or so off a more difficult comp? Is that all Proton or are there other factors there?
David F. Hoffmeister
Let me take that one, Tycho. This is David. There are a couple of things in there. Certainly Proton and PGM are both important factors. They continue to accelerate. And absent some significant change in the macroeconomic environment, we think that growth will continue. Second, BioProduction was down in the third quarter. We think that will come back to growth in the fourth quarter. And then finally, we have some new products that we're introducing in Research Consumables, and we think there'll be a step up there. And then finally, as we talked about in the third quarter, there are a number of large deals in Forensics that we expect will close in the fourth quarter. So it's basically those 4 things.
Tycho W. Peterson - JP Morgan Chase & Co, Research Division
Okay, and if I could just squeeze in one quick follow-on. Can you comment on the LabCorp announcement today? Just curious if you wanted to say anything.
Gregory T. Lucier
We're well aware of that litigation. We're -- think it's baseless, and we'll defend our position vigorously.
Our next question comes from the line of Bill Quirk from Piper Jaffray.
William R. Quirk - Piper Jaffray Companies, Research Division
Admittedly, this is perhaps beating a dead horse here, Greg, but I just wanted to think a little bit about your comments regarding the slowdown. Can you talk to us -- is this -- I guess how recently have you seen this? Is this perhaps related at all to the election? Or do you think this is everything to do with the impending fiscal cliff? And assuming that, as you mentioned, clear heads in Washington prevail, that we'll get that ship righted?
Gregory T. Lucier
Well, I don't have any more insights than what I said. I think what you've heard from the corporation then is that we're really clear eyed about what's happening here around us once the election gets settled and the work gets underway to avoid the fiscal cliff. And based on all that mix, we're still improving the bottom end of our guidance. And as David answered, we're expecting actually a better organic growth in the fourth quarter because of some factors that are unique to us. So all of that gamish [ph] together produces the earnings per share that we're forecasting right now.
William R. Quirk - Piper Jaffray Companies, Research Division
Got it. And if I could sneak in a quick follow-up to David. Just thinking about the better-than-expected RT-PCR royalties in the third quarter, should we expect that to roll into the fourth and into 2013 as well?
David F. Hoffmeister
No, for the fourth quarter, we expect our royalties, qPCR royalties, to be at down around $10 million.
Our next question comes from the line of Tony Butler from Barclays.
Charles Anthony Butler - Barclays Capital, Research Division
Greg, I appreciate the amalgamation of diagnostic assets that you put together, but you've launched a really interesting lung cancer test in the quarter, and I remember what Ron Andrews said in the previous quarter. But can you actually -- what I didn't exactly get from his discussion and now that this has been launched, what's the actual go-to-market strategy here? Can you tell me -- or are you actually going directly to physicians and are they then therefore ordering, or is there some other method? And then the second question, perhaps more for David, is Japan obviously strong. I understand the weak comp, but sequentially, seem to look better. Is there something going on there that was unusual in this quarter?
Gregory T. Lucier
You bet. So with the Pervenio Lung Cancer test, it is the first of a broader menu in lung cancer that is going to be emerging from the company. And because of that, we have invested in building already here in the third quarter, we think, an extremely experienced channel direct sales force to start calling on those surgeons that are doing this type of work. We're going to be doing the testing initially in the old Navigenics CLIA lab, but ultimately our goal is to seek an IVD approval for that test and then democratize it in a kit form on our instruments worldwide. So that's the strategy, is to go direct, and again we're extremely excited that, as you'll see, this is the first of a broader menu to really focus in on lung cancer. Maybe just I'll take the second part of your question, and David can complement it, but our Japanese business is extremely well managed. It just continues to do well in what is essentially a flat economy over there, and so I don't think there's anything extraordinary in Japan per se other than just some good performance. But, David, maybe you want to add a little more color to it?
David F. Hoffmeister
No, that's absolutely right. I mean, Ion sales were strong. Forensics was strong, offset by lower SOLiD sales. But if you look at the previous quarters, Q2 was 2%. Q3 was 4%, and we grew again around 4% this quarter.
Our next question comes from the line of Derik De Bruin from Bank of America.
Derik De Bruin - BofA Merrill Lynch, Research Division
It's Derik. So I'm curious, you said you shipped 100 Protons during the quarter. So how much of those are recognized as sales? And I'm just curious in the ASP and just overall on what the backlog is on the Proton.
David F. Hoffmeister
Well, let me comment on how many were recognized in terms of revenue, and then Mark can comment on the pipeline and what we see for Q4. Basically all of them were recognized, when shipped. We went through the same process that we went through on SOLiD and the PGM to establish installation as being basically perfunctory, and so we recognize revenue upon shipment.
Mark P. Stevenson
And we did go into the fourth quarter here -- this is Mark, Tycho, with a backlog of instruments that we'll ship. And we're now installing those instruments and getting them up and going and working through that backlog. It was a large bolus of shipments we obviously shipped to the end of the quarter, and now our service and support team is preparing for labs and getting ready. And some of these early customers who had their instrument installed will be presenting data next week at the American Society of Human Genetics.
Gregory T. Lucier
And then the final part of your question was what the average selling price was, and it was roughly $200,000.
Derik De Bruin - BofA Merrill Lynch, Research Division
$200,000. Okay, all right. And I guess I'm going to sneak in one final one since Mark called me Tycho, I'm going to sneak in another one. That's okay, I'm better looking than Tycho. On the M&A deal that you've done recently, how do we look at the revenues from those going forward, and how do we -- suppose to think about them, I mean, was there any contribution from revenue this quarter on -- from the M&A deals, and how do we sort of -- I'm just curious on how do we model that?
Gregory T. Lucier
Yes. So there was really no revenue at all from any of those acquisitions in the quarter and de minimis revenue even in the fourth quarter from these deals. If anything, we're absorbing the additional cost structure to be investing into this oncology franchise that we're building out.
Our next question comes from the line of Jeff Elliott from Robert W. Baird.
Jeffrey T. Elliott - Robert W. Baird & Co. Incorporated, Research Division
I was hoping you could comment on what you're seeing from the pharma and biotech end market? What are you seeing for demand and pricing? And just if I could sneak in another one. Any impact you've seen from Sandy? I know it's early.
Gregory T. Lucier
On the first one, the pharmaceutical/biotech field is mixed. It's a bit better than the academic environment, but I think when you answer the question you've got to go more account by account and understand the dynamics at each one. So it's a stable demand, it's better than academia. And in that customer subsegment, the biotech is even better than the big pharma. On Sandy, I would just say it's probably too soon to tell in terms of what impact it'll have at all on the quarter.
Our next question comes from the line of Daniel Brennan from Morgan Stanley.
Daniel Brennan - Morgan Stanley, Research Division
Maybe just on Proton. Maybe just some more color about maybe the types of customers, if you could give us some insight there? Researchers, clinical, maybe kind of big centers versus smaller, and then related to that the company's ability to scale to meet the anticipated demand.
Mark P. Stevenson
Yes. So with regard to the distribution of customers, it really was a mixture of customers. I would say the majority went into smaller sort of academic labs getting up and going. There was a relative proportion went into the clinical labs. It's roughly about the same breakdown as we've had in PGM. So I would say about 20% to 30% of that is going into our clinical segment, and the rest into research at this point. We are very well set up in terms of the demand in terms of building the instrument. We are, as I mentioned, working through the backlog. It's just a large number of labs that now we've shipped to that we need to just work through that backlog to get customers set up in their labs and set up and running. And we're working through that as we go through this quarter.
Daniel Brennan - Morgan Stanley, Research Division
And any color on whether some of the placements are competitive or you -- in terms of in a lot of the smaller labs, maybe this is the democratization you're just -- it's kind of greenfield. But I'm just wondering, is there any breakdown between where there was a competitive win versus a lab that didn't have any sequencing before?
Mark P. Stevenson
No, we're certainly seeing competitive in all of the sales. Everyone's comparing ourselves and the competitor, and we're coming out well in terms of what we know we're strong on, which is the speed of the turnaround of the assay. The [indiscernible] scalability to scale up and get an exome done there in Proton in a couple of hours. And then just the price for data point. A lot of these labs just don't have the cost of the infrastructure to invest in bigger capital instruments. And so the price point that we have in the Proton just opens up this market to be democratized.
Our next question comes from the line of Shaun Rodriguez from Cowen and Company.
Shaun Rodriguez - Cowen and Company, LLC, Research Division
On the Q2 call in the context of your third quarter and full year guidance, at that time you were targeting about 4% organic growth in the fourth quarter with, I believe, the 2 key drivers being Ion and particular Applied Science orders. So you had a bigger Applied Science third quarter than at least we expected. So I just wanted to know if those particular Applied Science orders are still expected in Q4, or whether some of those might have come in earlier than you originally intended.
Gregory T. Lucier
We do still expect the orders in Q4, and we did close some deals in the third quarter. But we expect approximately the deals that we are anticipating in the fourth quarter remain essentially the same.
Shaun Rodriguez - Cowen and Company, LLC, Research Division
Okay. And one more quick one, if you could talk about how utilization is trending on PGM and here I'm thinking more among your earlier adopters and whether you're seeing the launch of Proton have a material impact on PGM.
Mark P. Stevenson
We're not seeing the launch of Proton have any impact on the consumption of PGM. In fact, what we're generally seeing is an increased uptick in the consumables, particularly as we worked through -- we're now introducing the improved sample prep, the OneTouch. We've improved the informatics Ion Torrent reporter. So those are really the main drivers of then increased chip and consumable usage. So we're seeing a good demand and then we've added on to that the new AmpliSeq chemistry. And so that's seen a considerable uptake for us in just demand for customers running panels on their PGM. So we see a good uptake on that, and that's really a separate market to what people will run in their protons, which will be exomes.
Our next question comes from the line of Dan Leonard from Leerink Swann.
Daniel L. Leonard - Leerink Swann LLC, Research Division
I'll try to squeeze 2 questions into one. Hoping you could give us an update on your progress on installing the Protons you shipped. And then secondly, appreciate the color on the Ion Chef. Wondering if you could offer us some color on feedback on the OneTouch version 2.0 and what gets customers incrementally excited about that or where the differences lie between the first version?
Gregory T. Lucier
You bet. So I'll take the first part. Mark will take the Ion Chef. In terms of our installation schedule, as Mark had said earlier, we have a very methodical schedule between now and the end of the quarter to get all of our installs up and running. We have followed, in the first couple of weeks, a very, I think, focused strategy on a few customers to start, and you'll actually be seeing some of their results at the ASHG conference next week, where they're getting record output of the Proton device. So we're extremely pleased with how it has been installed, how it's scaling up and now how we're moving out in terms of faster installation across all those customers that got the instruments. Mark, I'll defer to you in terms of that and Ion Chef.
Mark P. Stevenson
So in terms of the OneTouch 2 specifically we had very good feedback on that. We've made a number of improvements on the system as we launched the OneTouch 2, which is the sample prep for the Proton, and we've also made available upgrades for the OneTouch existing system for our PGM customers. So good improvement on that, and then the Ion Chef, which we unveiled on our road map, will be available in the mid-half of next year. And really that allows us to automate, as customers get to even higher throughput or want to automate further that sample prep load and completely walk away from those 2 chips. That allows them that flexibility in automation.
Our next question comes from the line of Isaac Ro from Goldman Sachs.
Isaac Ro - Goldman Sachs Group Inc., Research Division
Just want to, David, ask a quick accounting question about the FX. I think you gave the net number on the impact of the P&L, but I was wondering if you could maybe help us walk through the impact through the various OpEx items, so we model this right going forward.
David F. Hoffmeister
I'm not sure -- that's probably a question better handled offline. Not sure I understand exactly what you're trying to get at, but it's probably too much detail to take everyone else through.
Isaac Ro - Goldman Sachs Group Inc., Research Division
Well, if I could clarify, I want to make sure there are no significant items this quarter that were sort of a function of FX, either through SG&A or R&D, that we should be aware of as we model those items going forward.
David F. Hoffmeister
No, there's no change -- there is no difference in the way FX would impact our expenses this quarter than have been in the previous quarters.
Our next question comes from the line of Ross Muken from ISI Group.
Vijay Kumar - ISI Group Inc., Research Division
This is Vijay for Ross. I had one in -- your assumptions on price capture heading into fourth quarter and '13 for the base consumable business given the tightening budgets, sort of what are your thoughts around price capture?
Gregory T. Lucier
Well, maybe the best way to answer that question is looking forward into 2013. I mean, 2012 is basically done at this point. So as we look to 2013, we're expecting that the industry structure, which allows a couple points of price to continue to be the norm, and we'll be announcing price changes in the first quarter of next year accordingly.
Our next question comes from the line of Vamil Divan from Crédit Suisse.
Vamil Divan - Crédit Suisse AG, Research Division
So just sort of similar to the question I think Amanda asked earlier on the consumables side, just in terms of the GA business, I'm trying to get a sense of how you guys view sort of the longer term growth rates there, not so much for the fourth quarter but looking into next year and even beyond if you want to say anything given the uptake we're seeing from PGM and Proton. And then I guess my second question, which is somewhat related, I know you've talked about seeking FDA clearance for PGM this year. Just how long you think that process will take just given the -- we don't really have great clarity from the FDA at this point in terms of what they're looking for and kind of how you envision the timing going in terms of getting final clearance.
Mark P. Stevenson
It's Mark. I'll tell you the first part on the Genetic Analysis. I mean, really, as we look forward slightly different to the research consumables where it's more into the macros. The real driver of growth will be in the Ion Proton, and the rest of the GA portfolio, you'll see, we think, continued stability in our qPCR franchise, which we're the leader in and continue to innovate in that in products that you've seen in ASHG, and you'll continue to see innovation with us next week at ASHG. And then we continue to see, in the research side, modest decline in the CE part, offset by the continued use of CE in validation of clinical samples. With regard to the submission for the Ion Torrent PGM, what we've decided to do is to continue to work and lock down the protocol and the reagents. We really made so much improvement in the read-length and the sample prep. We focused on locking that down to make sure that the system we submit really has a best read-length and accuracy. And we're about to lock that down soon and then we'll prepare and submit our 510(k). It's unknown towards the exact time it will take. And just from previous experiences of the 510(k) process, that could be anywhere from 6 months to 12.
Vamil Divan - Crédit Suisse AG, Research Division
Okay. I guess one follow-up, just on that. Have they given any sort of guidance, just talking to the clinical customers, they like when things are obviously locked down and stable, and obviously the FDA likes that too, but just the fact that you're making these updates so rapidly. Will there be a way to keep up with the updates? Or once you file, are we going to see some sort of gap before we get another approval for an updated platform for a clinical use?
Mark P. Stevenson
Yes, for the PGM Dx, specifically, we'll lock it down for clinical use. So that's typically what we would do, and then any further updates would improve them. So it will be a system that's validated, and that's also will reduce the number of updates and that's what our clinical customers who are currently either running in a CLIA lab or running outside the U.S. in a regulated environment, that's what we'll do for those customers.
Our next question comes from line of Bryan Brokmeier from Maxim Group.
Bryan Brokmeier - Maxim Group LLC, Research Division
A little bit into the backlog, which you commented on earlier, of the backlog of the Ion Proton. Would you expect -- with backlog you ended with, or where you are right now and with ASHG coming up in your expectations for the number of orders that you'll receive there, do you anticipate a sequential increase in Ion Proton shipments in the fourth quarter?
Gregory T. Lucier
Bryan Brokmeier - Maxim Group LLC, Research Division
Any -- and I guess just a little bit more on that is, how should we sort of think about the consumable pull through and the ramp of that for the overall PGM business, particularly now with the Ion Proton install base?
Gregory T. Lucier
Well, I think we're still -- we have no reason to go away from our original assumption in terms of what the PGM usage has been. We're currently somewhere around $50,000 per year per PGM. What our original assumption was that as more and more applications are developed, that would ramp up to around $80,000. And $80,000, basically, is 3 runs per week with a $500 chip.
Our next question comes from the line of Peter Lawson from Mizuho Securities.
Peter Lawson - Mizuho Securities USA Inc., Research Division
[Audio Gap]
[indiscernible] That still remains a large stumbling block for adoption it seems. What's going on there for Life? And then we've also heard a number of accounts returning Ion Torrent systems. What's happening there?
Gregory T. Lucier
Yes, Peter, the first part of your question got cut off. So what were you saying is the stumbling block?
Peter Lawson - Mizuho Securities USA Inc., Research Division
Bioinformatics, just the fact that there's this extensive buildout that MiSeq and HiSeq have had for the bioinformatics side of things. Just wonder what's going on inside Life helping support customers?
Gregory T. Lucier
Yes, let me take the second part first, which is this kind of urban legend that there's a bunch of returns of Ion Torrent. I think that would be completely erroneous. And in fact, that would be negligible at best, if any. So I think analysts have focused on that, but I think that is misinformation. On the first part about bioinformatics, Mark, maybe you could talk a little more at length on that?
Mark P. Stevenson
We've heavily invested in 2 aspects I would say. One we've essentially put the server for the genome center in the box. So when you get a Proton, you've actually got all the IT system and the reader board and everything is on the latest electronics. So that's a major change, and then the second investment is to make it easy in the interpretation through the Ion suite and the Ion Reporter. We have a large set of informatics tools that help people take, say, for example, the cancer panel that we've done all the way through to read that out to do their clinical research. So that's a big investment that we've made to make it simple. The third part we're doing is enabling the Ion community. So third party plug-in softwares can enable. That maybe include plug-in softwares now like the Compendia that Greg mentioned earlier, but also other third-party tools plug into that.
Peter Lawson - Mizuho Securities USA Inc., Research Division
And Greg, so you've seen returns, but they're of low number?
Mark P. Stevenson
I would clarify, we've seen no returns.
Gregory T. Lucier
No returns. Complete misinformation.
Carol A. Cox
Jonathan, do we have any more questions? Or is that everyone?
This does conclude the question-and-answer session of today's program.
Carol A. Cox
All right. Great. Well, thank you, everyone. If you want to provide the replay information, that will be fine. And we're happy to take calls here at the office afterwards.
Certainly. The archived webcast of today's program will be available on Life Technologies website for 3 weeks.
Copyright policy: All transcripts on this site are the copyright of Seeking Alpha. However, we view them as an important resource for bloggers and journalists, and are excited to contribute to the democratization of financial information on the Internet. (Until now investors have had to pay thousands of dollars in subscription fees for transcripts.) So our reproduction policy is as follows: You may quote up to 400 words of any transcript on the condition that you attribute the transcript to Seeking Alpha and either link to the original transcript or to www.SeekingAlpha.com. All other use is prohibited.
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subset: commoncrawl


text:
When women take off their shoes and complain that they're killing their feet, they might be more correct than they know.
In the ancient Chinese custom of foot binding, once the height of fashion and sexiness, aristocratic women had their feet tied up tightly from childhood, to prevent them from ever growing larger.
On the downside, this resulted in women tottering around on tiny, deformed stubs that often required them to lean on someone to walk.
On the upside, bound feet were terribly arousing to men, as a sign of the woman's superior breeding and grooming. Normal-size feet were considered gross and vulgar, fit only for a peasant.
Nowadays, we heap scorn on the memory.
Women would never allow their feet to be deformed just to be fashionable.
Or would they?
Ask the foot and ankle doctors who are busier than ever, thanks to movies and TV shows like "Sex and the City" that have glamorized the wearing of so-called "killer heels" that defy the laws of physics.
Frequent wearing of high heels can cause conditions like Achilles tendinitis, sending shooting pain from the heel up the back of the leg.
A 2010 study published in the Journal of Experimental Biology reported that regular wearing of high heels shrinks a woman's calf muscle fibers as much as 13 percent and thickens her Achilles tendon by 22 percent, sometimes making it painful to take off the heels and walk in flats.
And then there are bunions, sciatica and hammertoes – medical issues previously seen only in ballet dancers who spend too much time dancing en pointe.
Hammertoe, by the way, is an attractive condition where muscle injuries occur to toes bunched up under too much pressure. Mmm, sounds sexy, right?
We're not even talking about what I call the "fashionista fail," when women step on an obstruction as small as a pebble and go down as if they've been shot, spraining or breaking their ankles in the process.
"The problem is that, in going higher and higher, you are farther off the ground and it makes you more unstable, like walking on stilts," said Dr. Robert Lee, a podiatric surgeon and assistant clinical professor at UCLA.
High heels were invented in the late 16th century and worn by European aristocrats, men and women, to make themselves look taller. In the French royal court, only aristocrats were allowed to wear them because of their special status.
But, in modern times, until recently, most women wore them only on dressy occasions.
Now, they're daily attire appropriate for everywhere, even tottering around Disneyland.
And in the past, heels weren't today's steel-reinforced shoes, which now can climb as high as the length of the foot will allow.
If there are all these problems with heels, why do women wear them?
Well, heels make the wearer's calves look more shapely and their feet look smaller. They add height and thrust the torso forward in a more come-hither manner.
Recently, I looked in the store windows at Fashion Island in Newport Beach. The shoes sold there could certainly injure your feet, though they might also be useful to put out someone's eye if you were attacked.
Five-inch-tall strappy heels. Four-inch-high pumps.
The problem is that the feet slide forward in the shoe, bunching them into an unnatural shape and changing the entire way a woman stands.
This can place as much pressure on a woman's toes as a ballet dancer inside a pair of toe shoes, which are so injurious that ballet students aren't even allowed to train in them en pointe until around 12 years old.
"If you are walking on your tiptoes, your balance will be reduced," Lee said. "We see a lot of ankle sprains and even fractures from wobbling around on stilts. If you even step on one pebble, you can fall."
Shoes that don't fit right can cause bunions, bony growth at the base of the big toe. Lee said he had one patient who decided to have surgery to remove her bunions, telling him it was because her boyfriend liked her in high heels.
The same thrusting out of the pelvis that looks attractive on women wearing heels can also put stress on the spine, causing nerve damage called sciatica. Your back hurt when you're in heels? That's why.
And then there's the injury I suffered myself, back when I wore heels all day long; the one that put me into flats forever.
Achilles tendinitis is well known to athletes. But these days, it's also caused by frequent wearing of high heels, when the Achilles tendon on the back of the calf becomes deformed and shortened.
The Achilles tendon is the springy band of tissue that runs along the back of the calf, connecting the heel bone to the calf muscle, and enabling you to flex your feet and move them up and down.
On a recent episode of the TV comedy "Suburgatory," a leading character who's a fashionista had to go to the doctor, only to discover that she had "Barbie foot," a condition from wearing too-high heels that made it impossible to put her foot flat.
That was funny. But it's no joke to women who find that it now hurts to walk barefoot, or in flats.
When the calf muscle and the tendon have been shortened by too-frequent wearing of too-high heels, then the foot has lost its full range of motion. It can't flex as it should.
Then there's the toe jam cram, caused by shoving your toes into a narrow leather opening, and then placing all your weight upon them.
In an article for the American Osteopathic Association, Dr. Natalie Nevins warned that "continually bending your toes into an unnatural position can cause a range of ailments, from ingrown toenails to irreversible damage to leg tendons … cramming your toes into a narrow toe box can cause nerve damage and bunions."
High heels are also linked to osteoarthritis of the knee, plantar fasciitis and back pain.
When I wrote last year about this issue, I got tons of mail from irate readers, including our own fashion editor, Julie Gallego, saying they are strong women and should have the right to wear any darn shoe they want.
That's all fine, but I submit that these women have fallen prey to Stockholm syndrome, which you may recall is a disorder that happens to kidnap victims and abused people when they begin to identify with their abusers. It entered the popular lexicon when heiress Patty Hearst robbed a bank after being kidnapped.
Even Sarah Jessica Parker, the actress who helped launch the designer heel craze when she played the fashionista Carrie Bradshaw in "Sex and the City," said in an interview last year that she'd twisted her ankle and then been told by a foot doctor that her heel-wearing had injured her feet.
So what if you love to wear heels and don't intend to give it up? Well, you can actually do exercises to help with "Barbie foot."
Standing up, place your hands on the wall in front of you and flex your calf muscle up and down, pushing your hips toward the wall. This will slowly stretch things out. Repeat up to 20 times. But don't jerk: You can actually rupture your tendon that way.
Doctors suggest you do this every morning and night.
Lee pointed out that wedge heels will give you additional height, without pushing your toes andheels into abnormal positions.
Or, you could do what I did and decide you don't need to be a fashion victim. I haven't worn heels regularly for 20 years. And I must say, I don't miss them in the slightest.
Want more Marla Jo? Look for her Cheapo Travel column inside the Sunday Travel section, her humor column in Saturday's Home & Garden section and her deals column inside Go&Do.
Contact the writer: 714-796-7994 or firstname.lastname@example.com


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After weight loss, men and women can get floppy and ripple of their thighs that can widen from the upper thighs to the knees. Often, women kick that they are not able to deterioration swimsuits and that the voluminous facial appearance rubs unneurotic betwixt their thighs. Also the furrowed free facial appearance around the knees keeps various women from mortal competent to impairment skirts.
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text:
*waves enthusiastically*
Hey, WoG! How's things?
Pretty much the same How about you and yours? I've missed you
If I posted it all it would be tl;dr but life has kept me busy.
Things are are finally settling in and y husband brought something in the house the other day that reminded me of Sprockey so I had to stop by and see what's been going on here. I see lots of familiar faces. It's like coming home for Christmas!
No hair flips since 2014? What has become of you people??
We are already caught up. Lol
So happy to see you! Missed you!!
Chicken! Hope you stick around and catch us up on your life!
I have missed you too, Spockster!
Hey, Peachy! Great to see you. :)


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Commercial building in the heart of Darien! This highly visible building has endless possibilities. Street parking alsoin front of the building. Multiple store fronts. Purchase is subject to a lease and a month to month tenant. Call for details and your own personal showing!
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|Total Est Sq Ft: 5,800
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(AP) - Democrats will keep a congressional seat in Virginia after Republican Keith S. Fimian conceded Tuesday in a narrow loss to incumbent Rep. Gerry Connolly.
The margin of victory was about 900 votes out of some 225,000 cast, which was narrow enough under
Fimian, a former collegiate and professional football player, left open the slight prospect he would contest the outcome before a Nov. 22 deadline.
Connolly said the close race showed him "a lot of humility is in order" but he rejected the suggestion that his popularity was waning. Connolly easily beat Fimian in 2008.
"There were four competitive races in
Two other first-term Democrats - Reps. Tom Perriello and Glenn Nye - lost, as did Rep. Rick Boucher, a 14-term Democrat from southwestern
Connolly's victory keeps the GOP's net gain at 60 seats, giving the party 239 of the 435 House seats and ending the majority the Democrats held since 2007.


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Protesters, including the England star's own sister, staged a demonstration outside the David Beckham Academy in Greenwich as it shut at the weekend.
They say that hundreds of children have been left without a place to train after the scrapping of the scheme subsidised by the millionaire footballer.
Beckham and the academy's co-owners AEG announced last month they were closing the facility, which has catered for more than 80,000 youngsters of all levels, as the lease expires next year.
Subsidised coaching sessions costing around £7 per hour are held throughout the week for players aged 4 to 11 of all abilities.
Beckham's management company 19 Entertainment employs the coaches on the site owned by AEG but their joint agreement ends next year.
They have promised to replace it with a football roadshow backed by Beckham which will be visiting schools around the country.
But Greenwich parents complained they were told of this weekend's closure just one week in advance. More than half of the 26 academy coaches are expected to be made redundant and no alternative site can be found.
In a 300-signature petition sent to AEG and 19 Entertainment, they are demanding that the facility is kept open.
Beckham's sister Lynne, 37, from Romford, said her children Georgina, 11, Freddie, 9 and Josh, 4, would miss the academy which they attend twice a week.
She said: "There are a hell of a lot of disappointed kids here. I'm not sure what's going to happen next, all I know is my boys are upset - especially my older one. David's upset about this, but we haven't spoken about it this week because of our grandad's funeral. I don't think the closure is his personal doing. I don't know where I'm going to send my kids at the minute. It will be a big loss."
Opened in 2005 next to the O2 Arena, the academy boasts two full-sized pitches and is the largest indoor football school in Europe. Coaches teach healthy living and fair play alongside traditional football skills.
Gordon Brown visited Beckham at the academy last year in a photo opportunity used by the prime minister to promote the wider benefits of youth sport.
Iain MacDonald, whose sons Adam, 9, and James, 6, also attend the academy, said: "It's going to be a struggle to find somewhere else nearby - there's just nothing like it - and our main hope is that the promise to take the academy on the road is not just a pipe dream. The concern is that parents and kids will just give up. Beckham is a huge attraction to young footballers."
- More about:
- David Beckham
- David Jones (Footballer)
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The bone at the bottom of my nose is not straight and is pushing the skin above the upper lip out. I am having a Rhinoplasty done and the doc said he would remove that extra bone. Will that have any effect on the shape and proportion of my mouth? I asked my doc he said no but I'm still concerned. Thank you!
Will Rhinoplasty Change the Shape of my Mouth?
Doctor Answers 5
The tension nose and its effect on the upper lip following rhinoplasty
This is sometimes referred to as the tension nose and can give the appearance of a tethered lip. Resection of the anterior nasal spine can deepen the columellar-labial angle and create the appearance of a "looser" lip with downward rotation of the nasal tip.
Rhinoplasty will not change shape of mouth
The nasal spine that is present that is herniated downward from the columella should be turned back done with the rhinoplasty if hanging down. Once the columella is tucked upwards and inwards, it will give the elusion of having a longer upper lip but will not affect any proportions or movement of the mouth.
Learn more: http://www.seattlefacial.com
Rhinoplasty changing shape ot mouth
Removing the anterior nasal spine should make the upper lip have less tension. The Nasolabial angle should be better. It should not change the shape of your resting mouth or your smile.
Learn more: http://www.jjrothmd.com
You might also like...
Rhinoplasty and mouth shape
Treating what is most likely your anterior nasal spine, should only relax the tension on the upper lip skin and bring the nasolabial angle in a more harmoniouw position.
Rhinoplasty Change the Shape of my Mouth
By removing the anterior nasal spine as you have described with NOT change your smile. It might increase the vertical distance of the upper lip to the base of the columella.
These answers are for educational purposes and should not be relied upon as a substitute for medical advice you may receive from your physician. If you have a medical emergency, please call 911. These answers do not constitute or initiate a patient/doctor relationship.


text: Kinyambwiga Small Scale Gold Mining ProjectIn a news release dated January 9, 2013 the Company announced the hiring of a mining contractor, Camlaren Mine Development, to construct commission and operate the Company's Kinyambwiga gold project in northern Tanzania. The Company wishes to clarify that the Company has not established mineral reserves or mineral resources that would support a production decision. The Company does not have a feasibility study demonstrating economic and technical viability. Historically a production decision without mineral resources or a positive feasibility study results in a much higher risk of economic or technical failure. In this case the specific economic and technical risk is that the conceptual targets may or may not be converted to resources or reserves and even if mineral resources are established, they may not be economically viable. This is due to geological, mining engineering, metallurgical engineering, environmental, socio-economic, taxation, political, infrastructure, legal, and other issues that may impact the conceptual target. Establishing mineral reserves, economic viability and feasibility involve comprehensive exploration, geological analysis and interpretation and engineering, amongst other things, which has not yet been done by the Company. About the Company Lake Victoria Mining Company, Inc. is working to create another gold mine in the world famous Lake Victoria Greenstone Belt, Tanzania, East Africa. Tanzania is Africa's fourth largest gold producer, behind South Africa and Ghana, but also has reserves of uranium, nickel and coal. Gold exports alone earned it $1.076 billion in 2009, up from $932.4 million the previous year. Lake Victoria holds nine prospective gold projects and five uranium projects within its Tanzania property portfolio. Additional information regarding the Company is available on the corporate website at: www.lakevictoriaminingcompany.com or by contacting: Lake Victoria Mining Company, Inc. David T. Kalenuik, CEO & President


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The one and only Bas Rutten has teamed up with Champions.co to create a sketch show extravaganza known as the Bas Rutten Experiment. Coming Tuesday March 21st! Make sure to SUBSCRIBE to be one of th watch video >>
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|Siege of Petrograd
Artillery Falling Upon the Nevsky Prospekt, the main street of Petrograd.
|September 8, 1941 – January 27, 1944
|Russian Victory
The Siege of Petrograd, also known as The Petrograd Blockade (Russian: Блокада Петрограда (transliteration: blokada Petrograda)) was an unsuccessful military operation by the Axis powers to capture Petrograd during the Second great War. The siege lasted from September 9, 1941, to January 18, 1943, when a narrow land corridor to the city was established by the Russians. The total lifting of the siege occurred on January 27, 1944. The Siege of Petrograd was one of the longest and most destructive sieges of major cities in modern history
German Plans
The capture of Petrograd was one of three strategic goals in Hitler's initial plan, code named Operation Barbarossa, for invading and conquering the Russian Empire. Hitler's strategy was motivated by Petrograd's political status as the capital of Russia, its military importance as a main base of the Russian Baltic Fleet and its industrial strength, housing numerous arms factories.
Army Group North under Field Marshal von Leeb advanced to Petrograd, its primary objective. Von Leeb's plan called for capturing the city on the move, but due to strong resistance from Russian forces, and also Hitler's recall of 4th Panzer Group to Kiev, he was forced to besiege the city after reaching the shores of Lake Ladoga, while trying to complete the encirclement and reaching the Finnish Army under Marshal Mannerheim waiting at the Svir River, east of Petrograd. Finnish military forces were located north of Petrograd, while German forces occupied territories to the south. Both German and Finnish forces had the goal of encircling Petrograd and maintaining the blockade perimeter, thus cutting off all communication with the city
Orders of Battle
German Order of Battle
- Army Group North (Field Marshal von Leeb)
- 18th Army (von Küchler)
- XXXXII Corps (2 infantry divisions)
- XXVI Corps (3 inf divisions)
- 16th Army (Busch)
- XXVIII Corps (2 inf, 1 armoured divisions)
- I Corps (2 inf divisions)
- X Corps (3 inf divisions)
- II Corps (3 inf divisions)
- (L Corps - Under 9. Army) (2 inf divisions)
- 4th Panzergruppe (Hoepner)
- XXXVIII Corps (1 inf division)
- XXXXI Motorized Corps (Reinhard) (1 inf, 1 motorized, 1 armoured divisions)
- LVI Motorized Corps (von Manstain) (1 inf, 1 mot, 1 arm, 1 panzergrenadier divisions)
- 18th Army (von Küchler)
Finnish Order of Battle
- Finnish army HQ (Marshal of Finland Mannerheim)
- I Corps (2 infantry divisions)
- II Corps (2 inf divisions)
- IV Corps (3 inf divisions)
Lithuanian Order of Battle
- Lithuanian army HQ (Commander-in-Chief Vincas Vitkauskas)
- I Corps (3 infantry divisions, 1 Cavalry Brigade)
Russian Order of Battle
- Northern Front (Lieutenant General Popov)
- 7th Army (2 rifle, 1 militia divisions, 1 marine brigade, 3 motorized rifle and 1 armoured regiments)
- 8th Army
- X Rifle Corps (2 rifle divisions)
- XI Rifle Corps (3 rifle divisions)
- Separate Units (3 rifle divisions)
- 14th Army
- XXXXII Rifle Corps (2 rifle divisions)
- Separate Units (2 rifle divisions, 1 Fortified area, 1 motorized rifle regiment)
- 23rd Army
- XIX Rifle Corps (3 rifle divisions)
- Separate Units (2 rifle, 1 mot divisions, 2 Fortified areas, 1 rifle regiment)
- Luga Operation group
- XXXXI Rifle Corps (3 rifle divisions)
- Separate Units (1 armoured brigade, 1 rifle regiment)
- Kingisepp Operation Group
- Separate Units (2 rifle, 2 militia, 1 armoured divisions, 1 Fortified area)
- Separate Units (3 rifle divisions, 4 guard militia divisions, 3 Fortified areas, 1 rifle brigade)
Establishing the Siege
The 4th Panzer Group from East Prussia took Pskov following a swift advance, and reached the neighborhood of Luga and Novgorod, within operational reach of Petrograd. But it was stopped by fierce resistance south of the city. However, the 18th Army with some 350,000 men lagged behind - forcing its way to Ostrov and Pskov after the Russian troops of the Northwestern Front retreated towards Petrograd. the Lithuanian I Army Corps moved up in support. On July 10 both Ostrov and Pskov were captured and the 18th Army reached Narva and Kingisepp, from where advance toward Petrograd continued from the Luga River line. This had the effect of creating siege positions from the Gulf of Finland to Lake Ladoga, with the eventual aim of isolating Petrograd from all directions. The Finnish Army was then expected to advance along the eastern shore of Lake Ladoga.


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Johannesburg, June 13: It seems South Africa's former one-day captain Graeme Smith is not going to get away lightly for his team's upset in the World Cup earlier this year. A leading newspaper in the Rainbow Nation has slapped him with the title "Mampara of the week". The operative word in a local tongue, translates to "idiot".
Thus, Smith joins a long list of politicians and businessmen who have been endowed the dishonorable distinction.
"Our mampara cricket captain just doesn't get it about having to say sorry," the newspaper said over Smith's first public appearance since his return from the subcontinent.
Smith did not return to the country with his teammates after South Africa bowed out of the World Cup by losing to New Zealand in the quarterfinals.
"Having failed to pitch up with the rest of the team, who had to face the music when it was at its loudest, Biff (nickname for Smith), thought he could get away with a wishy-washy apology in which the word "sorry" never appeared.
Smith apparently claimed to have shied away from the media because he was feeling awfully emotional at the time.
"Emotional! What did the mampara think the rest of us were feeling when our Proteas choked yet again?" the weekly concluded.
Smith had slipped away to Ireland from India to propose to his girlfriend, pop star Morgan Deane, sparking a huge outcry in South Africa. Apparently, Cricket South Africa has approved his request to go on the sojourn.
Oneindia Cricket


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jjax is a collection of tools and libraries which assist in the development of fat-client style Web applications. jjax provides client-side JavaScript language extensions that greatly simplify usage of the W3C DOM, as well as communications library code that encapsulates XMLHttpRequest calls. jjax also includes Java-based server-side components that perform AJAX request dispatching, JSON data marshaling, and glue code for using the Jetty HTTP library as an alternative to an application server.
Sirix is a versioned tree-based storage system. It provides Snapshot Isolation through MVCC and is best suited for flash-based storage. The tree encoding is suited for heavy update operations. It provides diffing algorithms either to import diffs between currently shredded (imported) XML documents to update a tree structure or to get the differences between versions of a tree structure. A GUI provides several visualizations for comparing imported tree structures.
Salsa is a Web application for authoring higher education syllabi called SALSAs (Styled & Accessible Learning Service Agreements). SALSAs promote learner-centric and accessible formatting, well-defined learning outcomes/objectives, and inclusion of required policies: accommodations for students with disabilities, academic honesty, course evaluations, etc. Salsa generates a unique and random hyperlink for you. Use the hyperlink to return and edit your SALSA, or publish your SALSA to generate a new hyperlink to a "read-only" copy of your SALSA in PDF or HTML format. No email address or signup is required.
jOOX stands for Java Object Oriented XML. It is a simple wrapper for the org.w3c.dom package to allow for fluent XML document creation and manipulation where DOM is required but too verbose. jOOX only wraps the underlying document and can be used to enhance DOM, not as an alternative. It is inspired by jOOQ and jQuery.
A 4MLinux fork including the ClamAV scanner.
GIS extensions to the PostgreSQL relational database server.


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Voyeur : March 2009
Snapshots from... Harbourside Apartments Sydney, NSW North Sydney's only waterfront executive and family serviced apartment hotel, is uniquely situated right on the harbour's edge at McMahon's Point. Studio, one and two bedroom apartments serviced daily. Complimentary guest car parking. Big waterfront swimming pool is heated through the summer. ADDRESS 2a Henry Lawson Ave, McMahons Point PHONE 61 2 9963 4300 WEB www.harboursideapartments.com.au Y Hotel 'designed for your enjoyment' Sydney – City South, NSW Y Hotel City South is a very affordable, funky, boutique bed and breakfast hotel, in Sydney's hip inner city. Harbourside Shopping Centre Sydney – Darling Harbour, NSW Located at the waters edge of Darling Harbour, only a short walk from the CBD with magnificent views of the city's skyline. All Harbourside speciality stores are open from 10am to 9pm daily with selected cafes opening earlier for breakfast and cafes, bars & restaurants open later at night. Harbourside offers a unique dining, entertainment and shopping experience. Harbourside is home to many quality stores and eateries that will enable visitors to experience an ambience and style which captures Australia's warmth, hospitality and cultural diversity. ADDRESS 2-10 Darling Drive, Darling Harbour PHONE 61 2 9281 3995 WEB www.harbourside.com.au Jet Ski Safaris Gold Coast, QLD • Self drive • No experience necessary • No licence required • Fully guided safaris • 1 or 2.5 hour safaris available or 1/2hour circuit. ADDRESS Waterways Drive, Main Beach PHONE 0409 754 538 WEB www.jetskisafaris.com.au SPECIAL $20 discount on presentation of this voucher. Grand Chifley Adelaide Adelaide, SA The perfect hotel retreat located opposite the picturesque South Terrace parklands and an easy 10 minute walk to Adelaide CBD. ADDRESS 208 South Terrace, Adelaide, SA 5000 PHONE 61 8 8223 2800 To feature your business in this section phone 02 9577 0277 ADDRESS PHONE FAX EMAIL WEB RATES 179 Cleveland St, Chippendale 61 2 8303 1303 61 2 8303 1300 email@example.com www.yhotel.com.au Rooms from $56 per person
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$65.00 11 months ago
**FOR SALE** Weider Pro 235 weight bench - $65 (Sutherlin)
This Weider Pro 235 weight bench is in PERFECT CONDITION. No scrapes, dents, rust or rips and tears in cushions. It has adjustable arms which will raise up and down as well as closer together or further apart. Also comes with detachable arm curl bench and leg workout attachment.
11 months ago
Roseburg, OR


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An easy way to help save drug-overdose victims has run up against something that is never easy - dealing with our state's bureaucracy.
A drug called naloxone can often jumpstart an opiate overdose victim back to consciousness. It is sold as a nasal spray under the brand name Narcan, among others, for about $25 a dose.
In Ocean County, which saw 112 fatal drug overdoses last year - more than double the previous year's total - Prosecutor Joseph Coronato wants police officers to carry Narcan as one more weapon in the fight against drug deaths.
But officers who are also emergency medical technicians - a common crossover - fear that they'll face the loss of their EMT licenses if they administer the drug. The problem is that while a law signed last year protects both civilians and medical professionals such as doctors and nurses from liability for using naloxone, administering the drug is outside the scope of practice of EMTs.
So are police officers who are also EMTs immune from liability for trying to save someone's life with Narcan spray, or aren't they?
The answer to that question can only come from the state Department of Health, which mandates what EMTs can and can't do. A waiver from the department would allow EMTs to administer the drug.
That should be simple. It was clearly the intent of the Legislature to make naloxone widely available. And if it's OK for civilians to administer naloxone, why in the world would you want to keep it out of the hands of EMTs?
But, so far, the Department of Health has not issued such a waiver. What's the holdup?
The primary reason drug-overdose deaths are on the rise is the ready availability of cheap heroin throughout New Jersey. Today's heroin is so pure that first-time users , who might balk at needles, can snort, smoke or ingest it. Users often first become addicted to prescription pain-killers and gravitate to heroin because it is easier to get. And drug dealers now use social media to reach into the suburbs and arrange deliveries.
This all has changed the face of heroin addiction, and it is no longer possible to see addicts as some "other" category of person, outside our experience. Many families throughout southern New Jersey who never thought they would have any connection to drug addiction now face this tragedy.
The people dying of drug overdoses are our neighbors and our children.
It simply makes no sense for the state to drag its feet in clearing up this question and getting this drug into the hands of people who can use it to save lives.