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Stayed here with a friend 5 weeks ago. Arranged a pick up from the airport to the Riad by emailing them, which was just aswell as I am not sure we would have found it! Tucked down some alley ways! But although looks slighlty unsafe it is ok as plenty of people around to help you if you have any hassel! They do not like tourists being hasseled as they value their tourism too much!
The Riad is so pretty, lovely rooftop garden, especially nice around sunset with a chilled glass of wine listening to the mosque calls! Just ask the owners for a drink and they will bring drinks too you and add on to the bill for the end of your stay, nice touch was the complimentary olives or nuts.The owners are lovely and french but speak English which is just aswell as my french is as good as my arabic! Poor! Able to book tours for you here and advise on where is nice to visit, walking distance, directions etc. Rooms were lovely and cleam, very peaceful place to stay, would stay here again. Marrakesh is a crazy magical place, the souks, the atlas mountains (suurounding villages) the main square, the YSL gardens, all worth wandering round and getting yourself lost and emersed in the culture of it all!
- Official Description (provided by the hotel):
- Riad "Villa Harmonie" is situated in the heart of the Medina in the Kasbah district, just minutes walk from Jemaa El Fna square and the souks. Near the Bahia Palace, El Badi Palace, Saadi Tombs and the new Royal Palace. Access by car nearby. Parking near, Free WIFI. 7 NICE ROOMS. ... more less
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- Also Known As:
- Riad Villa Harmonie Hotel Marrakech


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Implementing Planned Markets in Health Care: Balancing Social and Economic Responsibility
Saltman, Richard B. and Otter, Casten von
Bibliographic Citation
Philadelphia, PA: Open University Press; Distributed by: Taylor & Francis, 1995. 260 p.
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Towards a Swedish Health Policy for the 1990's: Planned Markets and Public Firms Von Otter, Casten and Saltman, Richard B. (1991)
Equity and Distributive Justice in European Health Care Reform Saltman, Richard B. (1997)Equity is a central objective of most European health care systems, yet equity, particularly in the form of distributive justice, has not been a central objective of many recent health sector reforms. This article ...
European Health Care Reform: Analysis of Current Strategies Saltman, Richard B. and Figueras, Josep (1997)


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Probos are small drones that helped build Moonshine city and repair the Booster on Pioneer I
Anti-grav disc
On the very bottom of the Probo is a bronze colored disc that allows it to supend in mid-air.
robot arms
There are 4 robot arms with pinchers at the end to hold tools or reparing equpment.
The head(controls) are controlled by Moonbase II And Pioneer I.


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10 tracks of overdriven harsh noise, searing distortion and filthy feedback with HNW elements.
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|Publication number
|Publication type
|Application number
|Publication date
|Jan 27, 2009
|Filing date
|Oct 30, 2003
|Priority date
|Oct 30, 2002
|Fee status
|Also published as
|Publication number
|Carlos Schuler, Andrew R. Clark, Kevin R. Walsh, William Alston
|Original Assignee
|Nektar Therapeutics
|Export Citation
|BiBTeX, EndNote, RefMan
|Patent Citations (24), Non-Patent Citations (4), Referenced by (5), Classifications (9), Legal Events (5)
|External Links: USPTO, USPTO Assignment, Espacenet
This application claims the benefit of U.S. Provisional Patent Application Ser. No. 60/422,563, filed on Oct. 30, 2002, which is incorporated herein by reference in its entirety.
The need for effective therapeutic treatment of patients has resulted in the development of a variety of pharmaceutical formulation delivery techniques. One traditional technique involves the oral delivery of a pharmaceutical formulation in the form of a pill, capsule, elixir, or the like. However, oral delivery can in some cases be undesirable. For example, many pharmaceutical formulations may be degraded in the digestive tract before they can be effectively absorbed by the body. Inhaleable drug delivery, where an aerosolized pharmaceutical formulation is orally or nasally inhaled by a patient to deliver the formulation to the patient's respiratory tract, has proven to be a particularly effective and/or desirable alternative. For example, in one inhalation technique, an aerosolized pharmaceutical formulation provides local therapeutic relief to a portion of the respiratory tract, such as the lungs, to treat diseases such as asthma and emphysema. In another inhalation technique, a pharmaceutical formulation is delivered deep within a patient's lungs where it may be absorbed into the blood stream. Many types of aerosolization devices exist including devices comprising a pharmaceutical formulation stored in or with a propellant, devices that aerosolize a dry powder, devices which use a compressed gas to aerosolize a liquid pharmaceutical formulation, and similar devices.
One conventional type of aerosolization device is commonly referred to as a metered dose inhaler (MDI), which is sometimes referred to as a pressurized metered dose inhaler (pMDI). In a metered dose inhaler, a pharmaceutical formulation and a propellant are stored in a canister. In one version the pharmaceutical formulation is suspended within the propellant, and in another version the pharmaceutical formulation is dissolved in the propellant. In either version, a valve may be actuated so that a metered amount, or dose, of the pharmaceutical formulation is aerosolized in a manner where is may be inhaled by a user. The canister may contain one or more doses of the pharmaceutical formulation and generally contains sufficient amounts of propellant to allow for several actuations. Traditionally, the propellant comprises one or more chlorofluorocarbon compounds. However, non-chlorinated propellants, such as hydrofluoroalkanes, that are believed to be more environmentally friendly are proving to be a desirable alternative.
Though generally well accepted and inexpensive, metered does inhalers have certain drawbacks. For example, the amount of pharmaceutical formulation that may be aerosolized during an actuation is limited. In addition, it can often be difficult to control the efficiency of delivering large quantities of a pharmaceutical formulation using a metered dose inhaler.
Therefore, it is desirable to be able to aerosolize a pharmaceutical formulation in an efficient manner. It is further desirable to provide an improved metered dose inhaler that is capable of effectively aerosolizing a large quantity of a pharmaceutical formulation. It is still further desirable to provide an improved metered dose inhaler with improved aerosolization efficiency and reproducibility.
The present invention satisfies these needs. In one aspect of the invention a large and/or uniform aerosol dose of medicament is delivered from a metered dose inhaler.
In another aspect of the invention, an aerosolization apparatus comprises a container containing a pharmaceutical formulation, the pharmaceutical formulation comprising an active agent and a propellant; a metering chamber in communication with the container, the metering chamber adapted to hold a metered amount of the pharmaceutical formulation; a valve to allow the metered amount of the pharmaceutical formulation to be released from the metering chamber when the valve is actuated; and a pressurizer that applies pressure to the pharmaceutical formulation in the metering chamber while the pharmaceutical formulation is being released from the metering chamber, wherein the metering chamber is sized so that at least 2 mg of the active agent is be aerosolized for delivery to a user during inhalation.
In another aspect of the invention, an aerosolization apparatus comprises a container containing a pharmaceutical formulation, the pharmaceutical formulation comprising an active agent and a propellant; a metering chamber in communication with the container, the metering chamber having a metering volume of at least 150 μl and being adapted to hold a metered amount of the pharmaceutical formulation; a valve to allow the metered amount of the pharmaceutical formulation to be released from the metering chamber when the valve is actuated; and a pressurizer that applies pressure to the pharmaceutical formulation in the metering chamber while the pharmaceutical formulation is being released from the metering chamber.
In another aspect of the invention, an aerosolization apparatus comprises a container containing a pharmaceutical formulation, the pharmaceutical formulation comprising insulin and a propellant; a metering chamber in communication with the container, the metering chamber adapted to hold a metered amount of the pharmaceutical formulation; a valve to allow the metered amount of the pharmaceutical formulation to be released from the container when the valve is actuated; and a pressurizer that applies pressure to the pharmaceutical formulation in the metering chamber while the pharmaceutical formulation is released from the metering chamber.
In another aspect of the invention, a method of aerosolizing a pharmaceutical formulation comprises containing a pharmaceutical formulation in a container, the pharmaceutical formulation comprising an active agent and a propellant; metering an amount of the pharmaceutical formulation in a metering chamber in communication with the container; releasing the pharmaceutical formulation from the metering chamber when a valve is actuated; and applying pressure within the metering chamber during the release of the pharmaceutical formulation, wherein at least 2 mg of the active agent is be aerosolized for delivery to a user during inhalation.
In another aspect of the invention, a method of aerosolizing an insulin formulation comprises containing a pharmaceutical formulation in a container, the pharmaceutical formulation comprising insulin and a propellant; metering an amount of the pharmaceutical formulation in a metering chamber in communication with the container; releasing the pharmaceutical formulation from the metering chamber when a valve is actuated; and applying pressure within the metering chamber during the release of the pharmaceutical formulation.
These features, aspects, and advantages of the present invention will become better understood with regard to the following description, appended claims, and accompanying drawings which illustrate exemplary features of the invention. However, it is to be understood that each of the features can be used in the invention in general, not merely in the context of the particular drawings, and the invention includes any combination of these features, where:
The present invention relates to an aerosolization device, such as a device that uses a propellant for aerosolization, and its method of use. Although the process is illustrated in the context of aerosolizing a predetermined amount of a pharmaceutical formulation, the present invention can be used in other processes and should not be limited to the examples provided herein.
An aerosolization device 100 of the present invention is shown schematically in
In communication with the reservoir 110 is a metering valve 125 that is capable of allowing a metered amount of the pharmaceutical formulation to be released from the reservoir 110 in an aerosolized form. The operation of the metering valve 125 is shown in
The metered amount of the pharmaceutical formulation is ejected from the metering chamber 130 into the interior 150 of the expansion chamber 145 under the pressure of the flashing liquid propellant. As the propellant boils, vapor is generated to fill the void left in the metering chamber 130. In the expansion chamber 145 the pharmaceutical formulation undergoes expansion and further boiling. As a result, the metered amount of pharmaceutical formulation is discharged through a spray orifice 155 as an aerosolized pharmaceutical formulation 160.
In one version of the present invention, a pressurizer 165 provides additional pressure to the pharmaceutical formulation in the metering chamber 130 and/or the expansion chamber 145 during the aerosolization process. As the pharmaceutical formulation is released from the metering chamber 130, the quantity of propellant in the metering chamber 130 decreases and the pressure generated from the boiling propellant decreases. In addition, as the propellant exits the metering chamber 130, the expansion required to continuously fill the volume causes the propellant to cool which results in lower vapor pressures. The pressure generated from the propellant eventually becomes too low to effectively drive the pharmaceutical formulation out of the expansion chamber 145 and through the orifice 160. The pressurizer 165 provides additional pressure to compensate for this loss of pressure.
The added pressure from the pressurizer 165 allows for improved aerosolization of the pharmaceutical formulation. For example, in one version, the added pressure allows for a larger quantity of the pharmaceutical formulation to be aerosolized as a metered amount. Without the added pressure, the amount of pharmaceutical formulation that may be aerosolized is limited due to the dissipating energy from the reduced vapor pressure. However, with the added pressure from the pressurizer 165, the amount of pharmaceutical formulation that may be aerosolized is unlimited. Accordingly, in one version, the aerosolization device 100 aerosolizes more than about 2 mg, preferably more than about 3 mg, and more preferably more than about 5 mg of the pharmaceutical formulation. In addition, without the added pressure, aerosolized particle size distribution for even low quantity metered amounts may be unacceptably high. However, with the aerosolization device 100, the added pressure from the pressurizer 165 allows for small quantities of the pharmaceutical formulation to be more effectively aerosolized. For example, in one version, the aerosolization device 100 may aerosolize a metered amount containing more than about 0.5 mg of the pharmaceutical formulation with the aerosolized particle size distribution being acceptably low. The size of the metering chamber 130 and the amount of the pharmaceutical formulation delivered are limited only by the geometry of the device and the inhalation capabilities of a user. In one version, the volume of the metering chamber 130 may be at least about 50 μl, preferably at least about 150 μl, and more preferably at least about 300 μl, and most preferably about 360 μl. In one particular version, at least 50% of the aerosol particles generated have a diametric size of from 0.1 μm to 10 μm, more preferably from 1 μm to 5 μm. Even more preferably at least about 80% of the aerosolized particles are within the desired size ranges.
In one version, the pressurizer 165 may comprise a mechanism that changes the volume of the metering chamber 130. Since pressure is related to volume, by decreasing the volume of the metering chamber 130, the pressure in the chamber is increased. For example, as shown in
Alternatively or additionally, the pressurizer 165 may change the volume of the metering chamber 130 by providing the metering chamber 130 with one or more flexible walls 180, as shown for example in
In another version, the pressurizer 165 uses pressurized gas to add pressure to the metering chamber 130. For example, as shown in the version of
In particularly useful versions of the present invention, the metering valve 125 may be at least partially within the container 105. When the metering valve 125 is provided at least partially in the container 105, the pressurized pharmaceutical formulation may be used to supply the energy for the pressurizer 165. Thus, the need for an addition force applicator or source of pressurized gas is eliminated.
In like manner, the version of
In the version of
Other pressurizer 165 versions may also be used with the stem actuator. For example,
In another exemplary version,
The reservoir 110 may be in a canister in which a pharmaceutical formulation is stored in or with a propellant, such as a hydrofluoroalkane, as discussed in U.S. Pat. Nos. 5,225,183; 5,681,545; 5,683,677; 5,474,759; 5,508,023; 6,309,623 and in 5,655,520 all of which are incorporated herein by reference in their entireties. Propellant based metered dose inhalers may employ a dry powdered pharmaceutical formulation which is suspended or dissolved in a liquefied gas propellant. The pharmaceutical formulation may further comprise one or more excipients or surfactants to aid in the suspension and/or in the solubility, as discussed in the above-listed patents. After actuation, the propellant evaporates almost immediately leaving a fine dry powder.
In a preferred version, the invention provides a system and method for aerosolizing a pharmaceutical formulation and delivering the pharmaceutical formulation to the lungs of the user. The pharmaceutical formulation may comprise powdered medicaments, liquid solutions or suspensions, and the like, and may include an active agent.
The active agent described herein includes an agent, drug, compound, composition of matter or mixture thereof which provides some pharmacologic, often beneficial, effect. This includes foods, food supplements, nutrients, drugs, vaccines, vitamins, and other beneficial agents. As used herein, the terms further include any physiologically or pharmacologically active substance that produces a localized or systemic effect in a patient. An active agent for incorporation in the pharmaceutical formulation described herein may be an inorganic or an organic compound, including, without limitation, drugs which act on: the peripheral nerves, adrenergic receptors, cholinergic receptors, the skeletal muscles, the cardiovascular system, smooth muscles, the blood circulatory system, synoptic sites, neuroeffector junctional sites, endocrine and hormone systems, the immunological system, the reproductive system, the skeletal system, autacoid systems, the alimentary and excretory systems, the histamine system, and the central nervous system. Suitable active agents may be selected from, for example, hypnotics and sedatives, psychic energizers, tranquilizers, respiratory drugs, anticonvulsants, muscle relaxants, antiparkinson agents (dopamine antagnonists), analgesics, anti-inflammatories, antianxiety drugs (anxiolytics), appetite suppressants, antimigraine agents, muscle contractants, anti-infectives (antibiotics, antivirals, antifungals, vaccines) antiarthritics, antimalarials, antiemetics, anepileptics, bronchodilators, cytokines, growth factors, anti-cancer agents, antithrombotic agents, antihypertensives, cardiovascular drugs, antiarrhythmics, antioxicants, anti-asthma agents, hormonal agents including contraceptives, sympathomimetics, diuretics, lipid regulating agents, antiandrogenic agents, antiparasitics, anticoagulants, neoplastics, antineoplastics, hypoglycemics, nutritional agents and supplements, growth supplements, antienteritis agents, vaccines, antibodies, diagnostic agents, and contrasting agents. The active agent, when administered by inhalation, may act locally or systemically.
The active agent may fall into one of a number of structural classes, including but not limited to small molecules, peptides, polypeptides, proteins, polysaccharides, steroids, proteins capable of eliciting physiological effects, nucleotides, oligonucleotides, polynucleotides, fats, electrolytes, and the like.
Examples of active agents suitable for use in this invention include but are not limited to one or more of calcitonin, erythropoietin (EPO), Factor VIII, Factor IX, ceredase, cerezyme, cyclosporin, granulocyte colony stimulating factor (GCSF), thrombopoietin (TPO), alpha-1 proteinase inhibitor, elcatonin, granulocyte macrophage colony stimulating factor (GMCSF), growth hormone, human growth hormone (HGH), growth hormone releasing hormone (GHRH), heparin, low molecular weight heparin (LMWH), interferon alpha, interferon beta, interferon gamma, interleukin-1 receptor, interleukin-2, interleukin-1 receptor antagonist, interleukin-3, interleukin-4, interleukin-6, luteinizing hormone releasing hormone (LHRH), factor IX, insulin, pro-insulin, insulin analogues (e.g., mono-acylated insulin as described in U.S. Pat. No. 5,922,675, which is incorporated herein by reference in its entirety), amylin, C-peptide, somatostatin, somatostatin analogs including octreotide, vasopressin, follicle stimulating hormone (FSH), insulin-like growth factor (IGF), insulintropin, macrophage colony stimulating factor (M-CSF), nerve growth factor (NGF), tissue growth factors, keratinocyte growth factor (KGF), glial growth factor (GGF), tumor necrosis factor (TNF), endothelial growth factors, parathyroid hormone (PTH), glucagon-like peptide thymosin alpha 1, IIb/IIIa inhibitor, alpha-1 antitrypsin, phosphodiesterase (PDE) compounds, VLA-4 inhibitors, bisphosponates, respiratory syncytial virus antibody, cystic fibrosis transmembrane regulator (CFTR) gene, deoxyreibonuclease (Dnase), bactericidal/permeability increasing protein (BPI), anti-CMV antibody, 13-cis retinoic acid, macrolides such as erythromycin, oleandomycin, troleandomycin, roxithromycin, clarithromycin, davercin, azithromycin, flurithromycin, dirithromycin, josamycin, spiromycin, midecamycin, leucomycin, miocamycin, rokitamycin, andazithromycin, and swinolide A; fluoroquinolones such as ciprofloxacin, ofloxacin, levofloxacin, trovafloxacin, alatrofloxacin, moxifloxicin, norfloxacin, enoxacin, grepafloxacin, gatifloxacin, lomefloxacin, sparfloxacin, temafloxacin, pefloxacin, amifloxacin, fleroxacin, tosufloxacin, prulifloxacin, irloxacin, pazufloxacin, clinafloxacin, and sitafloxacin, aminoglycosides such as gentamicin, netilmicin, paramecin, tobramycin, amikacin, kanamycin, neomycin, and streptomycin, vancomycin, teicoplanin, rampolanin, mideplanin, colistin, daptomycin, gramicidin, colistimethate, polymixins such as polymixin B, capreomycin, bacitracin, penems; penicillins including penicllinase-sensitive agents like penicillin G, penicillin V, penicillinase-resistant agents like methicillin, oxacillin, cloxacillin, dicloxacillin, floxacillin, nafcillin; gram negative microorganism active agents like ampicillin, amoxicillin, and hetacillin, cillin, and galampicillin; antipseudomonal penicillins like carbenicillin, ticarcillin, azlocillin, mezlocillin, and piperacillin; cephalosporins like cefpodoxime, cefprozil, ceftbuten, ceftizoxime, ceftriaxone, cephalothin, cephapirin, cephalexin, cephradrine, cefoxitin, cefamandole, cefazolin, cephaloridine, cefaclor, cefadroxil, cephaloglycin, cefuroxime, ceforanide, cefotaxime, cefatrizine, cephacetrile, cefepime, cefixime, cefonicid, cefoperazone, cefotetan, cefmetazole, ceftazidime, loracarbef, and moxalactam, monobactams like aztreonam; and carbapenems such as imipenem, meropenem, pentamidine isethiouate, albuterol sulfate, lidocaine, metaproterenol sulfate, beclomethasone diprepionate, triamcinolone acetamide, budesonide acetonide, fluticasone, pratropium bromide, flunisolide, cromolyn sodium, ergotamine tartrate and where applicable, analogues, agonists, antagonists, inhibitors, and pharmaceutically acceptable salt forms of the above. In reference to peptides and proteins, the invention is intended to encompass synthetic, native, glycosylated, unglycosylated, pegylated forms, and biologically active fragments and analogs thereof.
Active agents for use in the invention further include nucleic acids, as bare nucleic acid molecules, vectors, associated viral particles, plasmid DNA or RNA or other nucleic acid constructions of a type suitable for transfection or transformation of cells, i.e., suitable for gene therapy including antisense. Further, an active agent may comprise live attenuated or killed viruses suitable for use as vaccines. Other useful drugs include those listed within the Physician's Desk Reference (most recent edition).
The amount of active agent in the pharmaceutical formulation will be that amount necessary to deliver a therapeutically effective amount of the active agent per unit dose to achieve the desired result. In practice, this will vary widely depending upon the particular agent, its activity, the severity of the condition to be treated, the patient population, dosing requirements, and the desired therapeutic effect. The composition will generally contain anywhere from about 1% by weight to about 99% by weight active agent, typically from about 2% to about 95% by weight active agent, and more typically from about 5% to 85% by weight active agent, and will also depend upon the relative amounts of additives contained in the composition. The compositions of the invention are particularly useful for active agents that are delivered in doses of from 0.001 mg/day to 100 mg/day, preferably in doses from 0.01 mg/day to 75 mg/day, and more preferably in doses from 0.10 mg/day to 50 mg/day. It is to be understood that more than one active agent may be incorporated into the formulations described herein and that the use of the term "agent" in no way excludes the use of two or more such agents.
The pharmaceutical formulation may comprise a pharmaceutically acceptable excipient or carrier which may be taken into the lungs with no significant adverse toxicological effects to the subject, and particularly to the lungs of the subject. In addition to the active agent, a pharmaceutical formulation may optionally include one or more pharmaceutical excipients which are suitable for pulmonary administration. These excipients, if present, are generally present in the composition in amounts ranging from about 0.01% to about 95% percent by weight, preferably from about 0.5 to about 80%, and more preferably from about 1 to about 60% by weight. Preferably, such excipients will, in part, serve to further improve the features of the active agent composition, for example by providing more efficient and reproducible delivery of the active agent, improving the handling characteristics of powders, such as flowability and consistency, and/or facilitating manufacturing and filling of unit dosage forms. In particular, excipient materials can often function to further improve the physical and chemical stability of the active agent, minimize the residual moisture content and hinder moisture uptake, and to enhance particle size, degree of aggregation, particle surface properties, such as rugosity, ease of inhalation, and the targeting of particles to the lung. One or more excipients may also be provided to serve as bulking agents when it is desired to reduce the concentration of active agent in the formulation.
Pharmaceutical excipients and additives useful in the present pharmaceutical formulation include but are not limited to amino acids, peptides, proteins, non-biological polymers, biological polymers, carbohydrates, such as sugars, derivatized sugars such as alditols, aldonic acids, esterified sugars, and sugar polymers, which may be present singly or in combination. Suitable excipients are those provided in WO 96/32096, which is incorporated herein by reference in its entirety. The excipient may have a glass transition temperatures (Tg) above about 35� C., preferably above about 40� C., more preferably above 45� C., most preferably above about 55� C.
Exemplary protein excipients include albumins such as human serum albumin (HSA), recombinant human albumin (rHA), gelatin, casein, hemoglobin, and the like. Suitable amino acids (outside of the dileucyl-peptides of the invention), which may also function in a buffering capacity, include alanine, glycine, arginine, betaine, histidine, glutamic acid, aspartic acid, cysteine, lysine, leucine, isoleucine, valine, methionine, phenylalanine, aspartame, tyrosine, tryptophan, and the like. Preferred are amino acids and polypeptides that function as dispersing agents. Amino acids falling into this category include hydrophobic amino acids such as leucine, valine, isoleucine, tryptophan, alanine, methionine, phenylalanine, tyrosine, histidine, and proline. Dispersibility- enhancing peptide excipients include dimers, trimers, tetramers, and pentamers comprising one or more hydrophobic amino acid components such as those described above.
Carbohydrate excipients suitable for use in the invention include, for example, monosaccharides such as fructose, maltose, galactose, glucose, D-mannose, sorbose, and the like; disaccharides, such as lactose, sucrose, trehalose, cellobiose, and the like; polysaccharides, such as raffinose, melezitose, maltodextrins, dextrans, starches, and the like; and alditols, such as mannitol, xylitol, maltitol, lactitol, xylitol sorbitol (glucitol), pyranosyl sorbitol, myoinositol and the like.
The pharmaceutical formulation may also include a buffer or a pH adjusting agent, typically a salt prepared from an organic acid or base. Representative buffers include organic acid salts of citric acid, ascorbic acid, gluconic acid, carbonic acid, tartaric acid, succinic acid, acetic acid, or phthalic acid, Tris, tromethamine hydrochloride, or phosphate buffers.
The pharmaceutical formulation may also include polymeric excipients/additives, e.g., polyvinylpyrrolidones, derivatized celluloses such as hydroxymethylcellulose, hydroxyethylcellulose, and hydroxypropylmethylcellulose, Ficolls (a polymeric sugar), hydroxyethylstarch, dextrates (e.g., cyclodextrins, such as 2-hydroxypropyl-β-cyclodextrin and sulfobutylether-β-cyclodextrin), polyethylene glycols, and pectin.
The pharmaceutical formulation may further include flavoring agents, taste-masking agents, inorganic salts (for example sodium chloride), antimicrobial agents (for example benzalkonium chloride), sweeteners, antioxidants, antistatic agents, surfactants (for example polysorbates such as "TWEEN 20" and "TWEEN 80"), sorbitan esters, lipids (for example phospholipids such as lecithin and other phosphatidylcholines, phosphatidylethanolamines), fatty acids and fatty esters, steroids (for example cholesterol), and chelating agents (for example EDTA, zinc and other such suitable cations). Other pharmaceutical excipients and/or additives suitable for use in the compositions according to the invention are listed in "Remington: The Science & Practice of Pharmacy", 19th ed., Williams & Williams, (1995), and in the "Physician's Desk Reference", 52nd ed., Medical Economics, Montvale, N.J. (1998), both of which are incorporated herein by reference in their entireties.
The pharmaceutical formulation may also be treated so that it has high stability. Several attempts have dealt with improving suspension stability by increasing the solubility of surface-active agents in the HFA propellants. To this end U.S. Pat. No. 5,118,494, WO 91/11173 and WO 92/00107 disclose the use of HFA soluble fluorinated surfactants to improve suspension stability. Mixtures of HFA propellants with other perfluorinated cosolvents have also been disclosed as in WO 91/04011. Other attempts at stabilization involved the inclusion of nonfluorinated surfactants. In this respect, U.S. Pat. No. 5,492,688 discloses that some hydrophilic surfactants (with a hydrophilic/lipophilic balance greater than or equal to 9.6) have sufficient solubility in HFAs to stabilize medicament suspensions. Increases in the solubility of conventional nonfluorinated MDI surfactants (e.g. oleic acid, lecithin) can also reportedly be achieved with the use of co-solvents such as alcohols, as set forth in U.S. Pat. Nos. 5,683,677 and 5,605,674, as well as in WO 95/17195. Unfortunately, as with the prior art cosolvent systems previously discussed, merely increasing the repulsion between particles has not proved to be a very effective stabilizing mechanism in nonaqueous dispersions, such as MDI preparations. All of the aforementioned references being incorporated herein by reference in their entireties.
"Mass median diameter" or "MMD" is a measure of mean particle size, since the powders of the invention are generally polydisperse (i.e., consist of a range of particle sizes). MMD values as reported herein are determined by centrifugal sedimentation, although any number of commonly employed techniques can be used for measuring mean particle size. "Mass median aerodynamic diameter" or "MMAD" is a measure of the aerodynamic size of a dispersed particle. The aerodynamic diameter is used to describe an aerosolized powder in terms of its settling behavior, and is the diameter of a unit density sphere having the same settling velocity, generally in air, as the particle. The aerodynamic diameter encompasses particle shape, density and physical size of a particle. As used herein, MMAD refers to the midpoint or median of the aerodynamic particle size distribution of an aerosolized powder determined by cascade impaction.
In one version, the powdered formulation for use in the present invention includes a powder having a particle size selected to permit penetration into the alveoli of the lungs, that is, preferably 10 μm mass median diameter (MMD), preferably less than 7.5 μm, and most preferably less than 5 μm, and usually being in the range of 0.1 μm to 5 μm in diameter. The delivered dose efficiency (DDE) of these powders may be greater than 30%, more preferably greater than 40%, more preferably greater than 50% and most preferably greater than 60% and the aerosol particle size distribution is about 1.0-5.0 μm mass median aerodynamic diameter (MMAD), usually 1.5-4.5 μm MMAD and preferably 1.5-4.0 μm MMAD. These dry powders have a moisture content below about 10% by weight, usually below about 5% by weight, and preferably below about 3% by weight. Such powders are described in WO 95/24183, WO 96/32149, WO 99/16419, and WO 99/16422, all of which are all incorporated herein by reference in their entireties.
In one particular example, the pharmaceutical formulation comprises insulin. Example of suitable suspension or solution insulin formulations can be found in U.S. Pat. Nos. 5,006,343; 5,364,838; 6,432,383; 6,540,982, all of which are incorporated herein by reference in their entireties. A particularly useful formulation of insulin comprises insulin in a phospholipid matrix, as disclosed in U.S. Pat. No. 6,433,040 and suspended in an HFA propellant as described in U.S. Pat. No. 6,309,623, both of which are incorporated herein by reference in their entireties. The advantage of aerosolizing the insulin formulations using the aerosolization device 100 of the present invention is that large and/or uniform doses can be generated that are not possible to generate in conventional meter dose inhalers. For example, at least a 2 mg dose of insulin can be administered using the above formulations in combination with an aerosolization device 100 of the present invention. In other versions, at least 3 mg and at least 5 mg of insulin can be aerosolized for delivery to a patient in need of insulin.
A capture chamber may be provided in certain applications. Suitable capture chambers are disclosed in U.S. Pat. Nos. 5,458,135; 5,740,794; 6,257,233; and 4,534,343, all of which are incorporated herein by reference in their entireties. The capture chamber may be useful when a user is unable to coordinate his or her inhalation with the actuation of the aerosolization device 100 or when the dose is sufficiently large that it is aerosolized in a manner than causes a stream of medicament to impact the back of a user's throat during use.
Although the present invention has been described in considerable detail with regard to certain preferred versions thereof, other versions are possible, and alterations, permutations and equivalents of the version shown will become apparent to those skilled in the art upon a reading of the specification and study of the drawings. For example, the relative positions of the elements in the aerosolization device may be changed, and flexible parts may be replaced by more rigid parts that are hinged, or otherwise movable, to mimic the action of the flexible part. In addition, the passageways need not necessarily be substantially linear, as shown in the drawings, but may be curved or angled, for example. Also, the various features of the versions herein can be combined in various ways to provide additional versions of the present invention. Furthermore, certain terminology has been used for the purposes of descriptive clarity, and not to limit the present invention. Therefore, any appended claims should not be limited to the description of the preferred versions contained herein and should include all such alterations, permutations, and equivalents as fall within the true spirit and scope of the present invention.
|Cited Patent
|Filing date
|Publication date
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|Philip Meshberg
|Metering valve
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|Ciba Geigy Corp
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|Mar 30, 1982
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|Etablissements Valois
|Metered aerosol valve for use in inverted position
|Sep 8, 1981
|Feb 28, 1984
|Karl Galia
|Metered quantity dispensing valve
|Jan 16, 1985
|Mar 25, 1986
|Etablissements Valois
|Valve for dispensing a measured volume of fluid from a container containing a fluid substance under pressure
|Sep 9, 1986
|Apr 11, 1989
|Minnesota Mining And Manufacturing Company
|Apparatus and methods for delivering a predetermined amount of a pressurized fluid
|Jul 25, 1988
|Jan 9, 1990
|Martin James H
|Unit dose dispenser
|Jul 10, 1990
|Sep 17, 1991
|United Kingdom Atomic Energy Authority
|Aerosol dispenser with flow diverter
|Feb 27, 1990
|Nov 5, 1991
|Minnesota Mining And Manufacturing Company
|Equine aerosol drug delivery method and apparatus
|Jun 10, 1991
|Feb 2, 1993
|Martin James H
|Piston operated fluid dispensing device
|Jun 21, 1993
|Oct 25, 1994
|Sherwood Medical Company
|Ventilator manifold with accessory access port and adaptors therefore
|Jan 29, 1993
|Nov 15, 1994
|Miris Medical Corporation
|Method of administration of insulin
|Jun 16, 1993
|Nov 22, 1994
|Perfect-Valois Ventil Gmbh
|Deformable container for delivering liquid
|Jun 2, 1995
|Sep 2, 1997
|Boehringer Ingelheim International Gmbh
|Atomizing devices and methods
|Jul 1, 1996
|Jan 11, 2000
|Aradigm Corporation
|Intrapulmonary delivery of hematopoietic drug
|Jun 18, 1998
|Jul 17, 2001
|Clavius Devices, Inc.
|Breath-activated metered-dose inhaler
|Dec 10, 1999
|Jan 29, 2002
|Bespak Plc
|Inhalation apparatus
|Mar 30, 2000
|Aug 13, 2002
|Generex Pharmaceuticals Incorporated
|Method for administering insulin
|Oct 30, 2000
|Apr 1, 2003
|Aeropharm Technology Incorporated
|Medical aerosol formulation
|Mar 17, 1999
|Nov 11, 2003
|Smithkline Beecham Corporation
|Valve for aerosol container
|Title not available
|Sep 26, 2001
|Apr 18, 2002
|Glaxo Group Limited
|Medicament dispenser
|Dunbar et al., "An Experimental Investigation of the Spray Issued from a pMDI Using Laser Diagnostic Techniques", J. of Aerosol Med., vol. 10, No. 4, pp. 351-368, 1997.
|Dunbar et al., "Theoretical Investigation of the Spray from a Pressurized Metered-Dose Inhaler", Atomization and Sprays, vol. 7, pp. 417-436, 1997.
|Dunbar, "Atomization Mechanisms of the Pressurized Metered Dose Inhaler", Particulate Sci. and Tech., 15:253-271, 1997.
|Mohsen, "pMDI Aerosol Momentum Manipulation and Biotargeted Delivery", Respiratory Drug Delivery VIII, pp. 593-597, 2002.
|Citing Patent
|Filing date
|Publication date
|Jun 22, 2009
|Dec 6, 2011
|Novartis Ag
|Aeorosolization apparatus with air inlet shield
|Dec 17, 2008
|Dec 20, 2011
|Novartis Ag
|Increased dosage metered dose inhaler
|Dec 17, 2008
|Apr 16, 2009
|Nektar Therapeutics
|Increased Dosage Metered Dose Inhaler
|Jun 22, 2009
|Oct 22, 2009
|Novartis Pharma Ag
|Aeorosolization apparatus with air inlet shield
|Jun 8, 2010
|Dec 16, 2010
|Defyrus, Inc .
|Administration of interferon for prophylaxis against or treatment of pathogenic infection
|U.S. Classification
|128/200.23, 128/200.14
|International Classification
|Cooperative Classification
|European Classification
|Apr 8, 2004
Owner name: NEKTAR THERAPEUTICS, CALIFORNIA
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Comedy Of Errors much anticipated fourth album "House Of The Mind" is an exploration of the Jungian unconscious and non linear time. At once a departure and development from 2015's 'Spirit", "House Of The Mind" combines soaring anthemic melodies, Classical influences and hard driven Progressive sequences to produce a Sublime Symphonic Rock music.
The CD release features 5 new tracks plus as a bonus, the band have re-arranged and recorded the classic "Ever Be The Prize". Digipack with 12 page lyric booklet.


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Courtesy of Rap Radar
Check out Bad Gal Ri-Ri do the thing on the cover of British GQ as the photo gets inspiration from Greek mythologies' serpent woman Medusa who could turn people to stone if they stared into her eyes. The cover photo is very dope, check it out below from British GQ, which can be found on the December 2013 issue.
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Here's what Ghost says about the video:
Today is a very trying day for me. I'm blogging from the hospital as I await the doctor to tell me whether my Grandmother is going to live or die. She had a seizure that lasted for an hour which could've resulted in serious brain damage. I was suppose to release this video tonight at 8pm but decided to do so now. It's funny how life works… I thought about releasing this video a few days ago and scheduled it to release today — around the 1:17 mark of the video I discuss my grandmothers illness not knowing that she'd be in the hospital fighting for her life on the very day I set for release. With that said I dedicate this video to Doris Horton, my Grandma & inspiration. My love for you runs as deep as an ocean. – GW
Our prayers are with Ghost and his fam.
The music video is the first video from Ghostwridah's 305s & Heartbreak mixtape project from last year, which you can Download Here.
Ghost also launched his new website & blog today at www.Ghostwridah.com


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A beautiful cherry finish metal top rail adds beauty and interest to this silver geometric king headboard design.
Our team has over 100 years combined experience with contemporary lighting.
Every EuroStyleLighting.com order is backed by our 100% Satisfaction Pledge.
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Distances are calculated in a straight line and may not reflect actual travel distance.
It is important to note that this mortgage calculator is for guidance purposes only. Mortgage lenders have their own affordability criteria therefore it is important you speak to one of our Mortgage Advisers for further information and a more accurate indication of what products may be available to you and what your monthly mortgage payments are likely to be.
This attractive two bedroom detached bungalow has a spacious lounge/dining room which has plenty of room for all your sofa's and a table and chairs meaning its ideal for entertaining friends and family. The kitchen is situated conveniently next to the dining room and leads to a conservatory which boasts views over the attractive rear garden and patio. Both bedrooms have space for a double bed and are served by an attractive shower room. Ample parking is provided by a driveway and garage.
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You must visit this gorgeous hotel. It is heaven on earth! My husband and I got married at Villas Alturas on Dec. 8 and had the most wonderful, unforgettable experience. It exceeded my expectations in every way. The views are utterly indescribable. You have to see it to believe it. At night, the sky is astounding. All of us were memorized by the infinite number of stars you could see. I think each of us saw at least 1 shooting star!
The rooms at Villas Alturas are extremely clean and comfortable with the perfect amount of privacy. Our room was very spacious and offered kitchen amenities and a huge shower. The hammock on the balcony was a staple for me.
Perhaps the best part of this hotel is the staff. As other reviewers mentioned, we felt like family. Our family joined us, for a total of 10 of us staying at Villas Altruas. We all had such a great time. The staff made us feel very comfortable and relaxed. Cindy is so sweet, laid back, and accommodating. Victoria and Oscar were lots of fun and catered to our every need. They would frequently check in with us to make sure all was well and to see if we needed a cocktail, water, or anything at all. David cooked all of our meals, which we enjoyed very much. He baked our wedding cake (carrot cake), which was to die for! Cindy, Victoria, Oscar and David made our stay and wedding day so special and perfect.
I would love to go back Villas Alturas and will certainly recommend it to all of my friends. Next time, we would like to stay even longer. What a special, magical place. Also, if you're looking for a gorgeous and unique place to get married, Villas Alturas is the place to go!
- Official Description (provided by the hotel):
- Villas Alturas offers the perfect combination of peace and quiet, views, sun, beach and adventure. Situated in the Costa Ballena area, only 35 minutes south of Manuel Antonio, you can enjoy the cool beachy vibe of Dominical 15 min away, explore the Marino Ballena National Park in Uvita or sample the international cuisine offered in Ojochal. Villas Alturas offers a complimentary breakfast every morning and the restaurant is open for lunch and dinner every day. We will plan and book all of your tours as well as help you to connect with all of the local free adventures. Barbque grill, free parking, a/c bedrooms, great pool area with an incredible views! Our road was improved in December, 2013 very easily accessible. We can accommodate 30+ people for your parties, destination wedding or any other event. Time to breathe . . . Terms and Conditions ---------------------------------------------- AMEX is not accepted at this time Payment Policy: Rates include breakfast and daily maid service. Sheets are changed every third day. (Breakfast that is included in the rate for a One Bedroom Villa is for 2 people, Breakfast for a Two Bedroom Villa is for 4 people. ) Above rates INCLUDE 13% sales tax for the room only. A 10% service charge plus tax will be added to all restaurant and bar purchases. Management reserves the right to POSSIBLY withhold deposit per their discretion at time of reservation and is as follows: 50% of reservation is due at the time of booking. The remaining 50% is due at check out. The maximum guests in our villas is 2 per bedroom plus one additional if the villa contains a futon. Check-in time is 2:00pm. Check-out time is 10am. Early check-in and late check-out are subject to availability and may incur a charge. High season is December through April excluding holidays. Green season is May through November. Holiday rates apply December 20th through January 5th and require a 5 night minimum stay. Management declines all responsibility for valuables left in the villas. Cancellation Policy: There is no refund if cancellation is made 14 days or less prior to the reservation date. When cancellation notification is received between 15 and 30 days prior to the reservation, a $50 processing fee per room will be charged. Payment will be forfeited if guest(s) arrive after the specific date of reservation or depart prior to final day of reservation. All cancellations need to be sent via e-mail. A cancellation is not confirmed until you have received an email or fax confirmation from us. ... more less
- Reservation Options:
- TripAdvisor is proud to partner with Booking.com, Expedia, Orbitz, Hotels.com, Priceline, Travelocity, Hotwire and Cheap Tickets so you can book your Villas Alturas reservations with confidence. We help millions of travelers each month to find the perfect hotel for both vacation and business trips, always with the best discounts and special offers.
- Also Known As:
- Villas Alturas Hotel Dominical
- Villas Alturas Costa Rica/Dominical


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And for the first time in his career, as he limped in and out of the French Open quarterfinal, he looked his age.
In the last 24 hours, two boats bypassed Lampedusa and limped into the port of Catania on the Sicilian island.
When the speech ended, with "I am proud to present . . . " Furry, carrying his battered Epiphone guitar, limped onto the stage.
Even Rep. Michele Bachmann, usually a prolific fundraiser, limped across last year's finish line with about $12 million.
Mitt, who garnered 29 percent in Missouri in 2008, limped in with 25 percent—less than half the votes Santorum earned.
She limped over to the divan upon which Cornelius Allendyce sat.
Barney limped into the kitchen and went to work on the window glass.
He knew that in damp weather Batty limped and confessed that his leg pained him a bit, from an old hurt he 'd had in the East.
At first the pain was not great, and he only limped as he walked.
Without another word, the unfortunate heir of so much wealth turned and limped into the hall with surprising rapidity.
1560s, of unknown origin, perhaps related to Middle English lympen "to fall short" (c.1400), which is probably from Old English lemphealt "halting, lame, limping," which has a lone cognate in the rare Middle High German limphin, and perhaps is from a PIE root meaning "slack, loose, to hang down" (cf. Sanskrit lambate "hangs down," Middle High German lampen "to hang down"). Related: Limped; limping. As a noun, 1818, from the verb.
1706, "flaccid, drooping," of obscure origin, perhaps related to limp (v.).
1706, "flaccid, drooping," of obscure origin, perhaps related to limp (v.).
limp (lĭmp)
An irregular, jerky, or awkward gait; a claudication. v. limped, limp·ing, limps
To walk lamely, especially with irregularity, as if favoring one leg.


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Mabson Enterprises have compiled 37 artists via social media that are twerking hard or hardly twerking with a vast array of unique covers and remixes of Miley Cyrus' smash summer jam, "We Can't Stop."
Featuring a sweet, 90s inspired cover image and artists like Dan Deacon and Capital Cities with many reworked song titles such as "We Can't Stop (But Perhaps We Should Have A Long Long Time Ago)," "Miley Can't Stop Sniffing Coke With Evanescence Backstage," and "The Queen of Twerking gets an Achy Breaky Heart," this massive mixtape has a little (or lot) to offer for everyone in search of some new ways to enjoy Miley's material…or Miley being made into more of a mockery. Not all of the offerings are facetious in nature though.
Dan Deacon's contribution in particular is simple in the sense that he did nothing more than reduce the track by 50%. "I remixed this track by removing audio. Nothing was added, only taken away." Hardly twerking, Dan.
You can stream all 37 tracks via Bandcamp and download it for free or offer some money with the "name your price" option if you're looking to blow some clams on something different. Blow some clams, man!
Brian Leak
Latest posts by Brian Leak (see all)
- UTG PREMIERE: Hymn – 'Mouth' EP - June 10, 2016
- SakkieFTW snaps you out of it with new EP, 'Experiment 1.3.2' - June 6, 2016
- The Lost Poets' 'Insubordia pt II' is dark and gritty - June 3, 2016


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Belgium capital Brussels may face Paris-like attacks and the entire city has entered a security lockdown today. Heavily armed police and soldiers have been deployed. Metro train services have also been shut down until Sunday evening.
Prime Minister Charles Michel said precise information reveals several individuals may launch multiple attacks in the city with guns and bombs.
The crisis center has raised the alert to 'Level Four' in the city which mean "serious and immediate threat."
The PM has urged people to stay calm and not to panic as the government has taken all the necessary measures for the safety of Brussels. They are also suggested to avoid places of large gathering such as airports, train stations, public transit, commercial districts, major events and concerts.
Meanwhile, a manhunt is also in progress for Paris attacks suspected attacker Salah Abdeslam who is on the run. He was last seen at the Belgian border last Saturday.


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This step is elective but will dramatically enhance your chances of your profile getting read by other members. Write a few sentences about yourself, your interests and upload a nice photo of yourself.
Use our website's sophisticated search to pinpoint members who suit your criteria. Or just browse through listings and pinpoint folks that interest you.
Discovered someone who you find interesting? Send a message to them or just a wink and await their reply. With a little luck you'll be on your way to finding your perfect partner.
It's quick and simple


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BlackBerry CEO John Chen had some seemingly irrational things to say about Apple's stance on encryption, and Bryan and Jeff break it down. They also take a deeper look into black boxes and self-driving cars with a focus on regulating these devices and surveillance worries. Just to keep things light, they dive into Twitter harassment and social media censorship.
ACM 369: BlackBerry Doofus, Black Box Regulation, Twitter Harrassment
Sources referenced in this episode:
- BlackBerry CEO 'disturbed' by Apple's hard line on encryption – The Inquirer
- Twitter cracks down after 'Ghostbusters' actor complains about abuse – Reuters
- If a Black Box in Apple's Autonomous Cars Recorded Everything, Would You Care?
- German Legislation Would Require 'Black Box' Tech for Self-Driving Cars
- Jeff's Twitter
- Bryan's Twitter
- Jeff's blog: Fresh Brewed Tales
- Bryan's blog: Geek Tells


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Bonefish Grill Map
340 Oyster Point Rd., Ste. 106
757-269-0002 | Make Restaurant Reservations | Menu
Need directions to Bonefish Grill? This map will help you find the best route to and from the restaurant so you can enjoy your meal. Clicking on the green arrow can help you get the best route to and from this restaurant if you don't see the "Get directions" pop-up.
Find out which restaurants and chefs top the list of GAYOT's 2016 Annual Restaurant Awards.


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About Me – Tim Garner
To me, life has always been a journey of self discovery so laying down a few paragraphs about who I am is kind of like trying to hit a moving target…and the moving target is me. It's been my experience that many "about us" pages are nothing more than lists designed to impress people with how brilliant the author is. As a rule, I don't like braggers and certainly don't want to be one so here's a quick outline of the things that matter to me and perhaps may also matter to you.
I am more than what I do
When someone asks me what I do for a living, I generally just tell them I'm a graphic designer because if I tell them what I actually do it would turn into a much longer conversation than either of us are prepared for. So while I do design logos and websites as well as other designerly things, it's not a very apt description of what I do. In essence, I help businesses understand what they want to achieve and then give them the tools to help them do that. I do that by learning about what motivates their customers and then help them figure out the best way to communicate who they are and what they have to offer to those customers.
I am the sum of my experience
I was raised in Nebraska and have always had an aptitude for art. I was the artist for the newspaper in both high school and college. I originally attended college with a fine art major but switched to commercial art when I realized that I would probably starve as a fine artist.
In my journey to my present career, I've worked in several industries. I started out as a paper boy, I've de-tasseled corn (a Midwest thing), I've worked in a meat pack, as a high rise window cleaner, a bartender, a waiter, a gas station attendant, a truck loader, a t-shirt artist, an electrical sign designer, a sign salesman, a sales manager, and a webmaster and probably several others I can't remember off the top of my head. All of these things have either led me or pushed me into my present career and while I wouldn't want to do most of them ever again, I don't regret a single one of them (except maybe the meat pack).
I am passionate
On a personal level, I am the youngest of three children. I am married to the girl I fell in love with so many years ago in college and with whom I am now raising three children of my own. My wife is my partner and my best friend, she does the majority of child rearing plus she helps me stay organized and focused on being a good provider for us all.
I'm passionate about my work and I feel incredibly fortunate that I get to get up everyday and do something I truly love. I'm one of the fortunate few that grew up and got to do exactly what they wanted to do when they were kids.
I am flawed
I think a big part of what makes a person who they are are the challenges they have faced in life and overcome. Professionally my biggest challenge has been my mediocrity. I'm pretty good at what I do but there are others who are better and there was a time when, in all honesty, I wasn't very good. It's taken a long time to reach the level I'm at now but I know I have much to learn and much farther to go.
My journey
I believe failures are just as important as successes. If success is a ladder, failure is the pathway that leads to the ladder. Things haven't always gone my way, I've seen my share of tragedy and I've experienced my share of pain and loss, personally and professionally. You either learn and grow from these things or you use them as an excuse to quit…quitting isn't an option.
I believe
I'm spiritual, I'm political, and I'm loaded with opinions but I believe those things are private and have no business coming to work with me. I believe life is a journey, not a race, and that we all share the same road and letting the other guy merge is always the right thing to do. I believe that experience, my parents, and my children are the best teachers I've ever had.
The best part of me…
Oh yeah…
In my spare time I feed a passion for photography, art and writing. Check out my other creative work at www.artistpoet.com.


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Netflix Earnings Preview Q3 2015
- Netflix is expected to report Q3 FY 15 earnings on Oct 14 after market close.
- The company is expected to report strong subscriber growth but lower profits due to growing content costs.
- Investors are, however, more likely to focus more on Netflix's subscriber growth and give the company a free pass on thinner profits.
Netflix (NASDAQ:NFLX) is expected to report third quarter earnings on Oct. 14 after closing bell. The video streaming giant is expected to report revenue of $1.751 billion, GAAP earnings of $0.08 and adjusted EPS of $0.10. Although Netflix's management had guided for adjusted earnings of $0.07. Netflix has managed to beat consensus earnings estimate for the last four quarters with a healthy average earnings beat of 26% and many analysts expect the company to extend this streak.
Quarterly Earnings Surprise History
Quarter End
Per Share
EPS* Forecast
Meanwhile, Netflix stock continues to march forward undeterred by the market downturn. Netflix stock is up 128% YTD.
Source:Netflix Stock Price Data by amigobulls.com
Subscriber growth expected to impress
The main reason why Netflix's stock has been doing so well is due to the company's impressive subscriber growth. Netflix's management had guided for at least 1.15 million domestic subscriber adds during the quarter, or 18% more than the company added during last year's comparable quarter, which will bring Netflix's total domestic subscribers to 43.47 million. Meanwhile, Netflix expects international subscriber growth to continue outpacing domestic growth. The company expect international subscriber adds to clock in at 2.4 million, 17.6% better than last year's comparable period. This will bring Netflix's international subscriber base to 25.65 million.
Netflix has been making strong inroads into new international markets. The company has entered several key markets over the past 12 months including Japan, Germany, France, Benelux, Australia, New Zealand, Italy, Spain and Portugal.
Rising content costs to pressure margins
Netflix has been investing heavily in original content as it seeks to cement its position as the world's leading video streaming company. These investments have been eating into the company's already thin margins causing Netflix earnings to decline. The expected $0.08 EPS actually represents a huge 48% Y/Y decrease compared to a healthy 24% growth in revenue.
Going by current industry trends, Netflix might have to pay more for its content going forward. There is growing resentment building up with Netflix' old media rivals which are increasingly viewing Netflix as a rival. During the September conference circuit, several media executives notably at 21st Century Fox and Time Warner talked about a need for the companies to rethink their strategy when licensing content to Netflix. These companies have increasingly been preferring to license content to Hulu instead of Netflix due to what they termed as Hulu's better compensation. Additionally, the cable companies have been blaming Netflix for the rampant cord-cutting going on in American homes, as well as falling TV ratings.
Netflix recently announced a $1 price increase for its base plan to $9.99 per month, which some analysts see as a demonstration of Netflix's pricing power while others are less sanguine and view is as a sign that Netflix is feeling the pinch from rising content costs.
Meanwhile Netflix has to contend with increasing competition not only from Hulu and Amazon Prime video but also from Apple (NASDAQ:AAPL) which is reportedly working on a streaming video service.
Going after the low-hanging fruit
Netflix investors are, however, not likely to be worried about the company's growing content costs. Netflix has been recording good success going after international subscribers which is an easy growth path for the company. International subscriber growth has continued to outpace domestic growth. The good part is that Netflix has plenty of room to run before it can become a truly global player. For the average large Internet company, international revenue accounts for around 70% of overall revenue whereas for Netflix that figure is still a lowly 30%. While Netflix earnings may experience pressure, as long as the company keeps adding subscribers at a healthy clip, investors will continue being happy with Netflix.


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Tag Archives: Soldiers of Allah
Muslim Soldiers of Allah Declared War on America 10 years ago Today, September 11, 2001
. A message to all who choose to wage war on Americans in the name of Allah… You started this war. Americans will finish it and you. You will pay with your life. Your seed will die with you. We … Continue reading
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This is the beginning of a 3 part project - I'm still working it out, so appreciate your patience.
The City - is driven by a monologue I started to write about London. I was working a particularly soul destroying admin role in the city and as I sat on the trains staring at my fellow commuters I couldn't help but wonder if this was what they had always imagined for themselves. How many wanted to be policemen, astronauts or an artist ... how many were happy in their roles or just did it to pay the bills.
Working a job I loathed, I felt like I was channelling the joint frustrations of all would be creatives into this monologue. I finished it and forgot about it, working several other jobs (most of them admin) in the meantime.
More recently I've become incredibly interested in the power of online communities and associated tools.
I think the power of the internet in creating communities and allowing eveyrone to find a place where they 'belong' is incredible. Beyond amazing. Especially, as I personally feel traditional communities are failing in many ways ... or at the very least floundering.
My definition of a community is ikely flawed, but I grew up in a small village, where everyone knew each other, were ready with a smile or a good morning. It might sound twee, but there was very little crime and very little disquiet in general. I was quite shocked when I moved down to SE London that my local area lacked the same open friendly attitude and couldn't believe the volumes of petty crime ... Now when I return to the village (where my dad still lives) I'm sad to see that as it's grown over the years, the community spirit has become "thin and sort of stretched, like butter scraped over too much bread" ...(thank you LOTRs) It's not that the sense of community or companionship is totally gone, it's just getting to the point where it struggles to reach into the outlying areas ... petty crime within this now town has increased and it's impossible to keep track of all the residents.
On the other hand, online, communities prevail. People across the globe gathering around a cause or craft with which they identify. The internet so often provides a home and outlet for those estranged from their physical communities (and the abuse of this tool at the hands of trolls is crushing).
Yet, we're looking at two sides of the same coin - the internet is both good and evil, awesome and horrifying ... I'm sitting on the train right now and as I type and stare down the carriage I can count 8 out of the 10 people I can easily see on phones or tablets.
Don't get me wrong, I love the internet. LOVE. IT. I wrote a couple of articles for work on why I think it is amazing and all the good it can do ... but I can't help but notice the irony, that while I am absorbed in the wonders of my fantastic online communities, I am isolated from the people around me. I probably check my social networks more in a day than I do start a conversation with an actual person ... when I do talk to people, I know that it's likely 1 out of 5 conversations will relate to something I saw online ... I avoid making eye contact with any of my fellow commuters and instead choose to stare at my phone, obsessively refreshing pages ... I'm sure many of the people around me are intelligent, articulate and passionate individuals. Maybe we like the same music, or art or films ... I'll probably never find out. I'm not likely to start a conversation with anyone. I realise the above sounds marginally nuts ... but I doubt I'm the only one, it's just become a habit.
And this is something that has inspired me.
I've exchanged obsessively checking my phone on the commute home for drawing those I see on the commute, with a view to create a series of paintings once I've gathered enough subjects.
I have never done any life drawing, so this is very new and exciting for me. I'm learning a lot about the fundementals of life drawing in a pressure free and exceedingly fast paced environment ...
I've been working in this manner for around a week and have narrowed down subjects to those who are so absorbed in what they're doing, they don't register me doodling away opposite them.
I'm also making a point of noting down how many people within my line of sight are: on phones; tablets; reading; or making conversation.
It might seem silly, but these are the first steps in what I think is going to be a great project.
Thank You!


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|734 sq. ft.
|Property type
Located 7-10 minutes drive from the airport and 2 minutes drive from the main beach of Pantai Cenang, this resort is convenient yet secluded.
At 120 years old, this Villa is very grand and charming with old plantation style shutters and intricate carvings. With two queen beds in one room and two single beds in another room, it is the ideal house for a family to feel at home.
Overlooking a tranquil lagoon this antique Malay home offers exclusive, intimate and secluded fine dining. The perfect venue for, small groups, and family gatherings.
Rates include continental breakfast, placed in your fridge the night before. All villas contain tea/coffee making facilities, toaster, fridge with complimentary water, sarongs and local slippers, TV, CD/DVD player. We have wireless (WiFi) Internet throughout the resort and a computer with printer for guest use.
Amenities include:
- Air Conditioning In Rooms
- Cots Available upon request
- Smoking Allowed In Public Areas
- Tea/Coffee Making Facilities In Each Room
- Hairdryer In Each Room
- Minibar In Each Room
- Laundry/Valet Service
- Pets Allowed in the public areas
- Car Parking Available Onsite
- Wi-Fi Available
- Wi-Fi Available In Public Areas
- Wi-Fi Available In Rooms
- Restaurant
- Outdoor Pool
- Video/DVD Library
- Video/DVD Player
House Rules: Late check-out is subject to availability, otherwise normal check-in time is 2:00pm and check-out time is 12:00pm midday.
Reception from 08:30 to 23:00
Pets allowed
Airport transfers are not available at this stage, however taxis and rental cars are readily available from airport arrival hall.


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Sporting ChanceSporting Chance (1963) - Krazy Kat Cartoon Episode Guide
This page has been viewed 58 times this month, and 834 times total.
- 1963
- Paramount Cartoon Studios
- Paramount Studios
- Krazy Kat Episode Guide
- Cartoon Characters: Krazy Kat, Ignatz Mouse, Officer Pupp.
- Vocal Talent: Penny Philips (Krazy Kat), Paul Frees (Ignatz Mouse, Officer Pupp).
- Directed By Gene Deitch (Supervising Director).
- Produced By William L. Snyder.
Executive Producer: Al Brodax.
- Written By George Herriman (Comic Strip).
Submit Additional Information:
Do you have anything to add to this page? Have we made any mistakes... or do you have any additional information about Sporting Chance? If so, we would love to hear from you. Please send us a quick note with your additions or corrections to this page, and we will make the corrections as soon as possible!Report Errors / Submit Additional Information
Cartoon Summary:
Krazy, upset that Ignatz decided to stop throwing bricks at her and went into sports (thanks to Officer Pupp's last warning), tries to get Ignatz into hitting her head with first a bowling ball, than a baseball. It doesn't work until Ignatz accidentally hits her... (more)
Cartoon Comments:
Do you love Sporting Chance, or do you think it is the worst cartoon ever? Let us know what you think! Surely you have an opinion... so share what you think. Take a minute and post your own comments about this cartoon here.


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Washington: Mila Kunis is reportedly "nervous" about giving birth to her and fiance Ashton Kutcher's first baby.
Mila Kunis
The 31-year-old star, who's in the last month of her pregnancy and only days away from delivering the child, has been busy with the preparations for welcoming their little one, and the to-be parents have finished the nursery in their 10-million-dollar Beverly Hills mansion.
Ashton, 36, had proposed to the beauty earlier in 2014 after dating her for years, and has remained by her side throughout the pregnancy, catering to her every need.


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It's been a while since I've shared one of my Plant-Powered Peeps interviews with you. I started the series a few years back to introduce you to some of the people who inspire me in terms of what they're doing in the plant-based space. Whether that be in relation to health and nutrition, animal welfare, or sustainability and the environment, I hope they will inspire you too. If you haven't read before about the benefits that a plant-based lifestyle can have in terms of those three key areas, then definitely check out my blog post from a while back here.
To kick off 2015's interviews, I'd love to introduce you to a wonderfully compassionate man, who works tirelessly campaigning for the welfare of animals. Hans is the CEO of SAFE (Save Animals From Exploitation), New Zealand's largest animal advocacy charity. SAFE are the guys and gals behind the scenes, campaigning against battery caged hens and eggs, confined pigs in metal crates, calve and cow injustices, as well as the mistreatment of circus animals and much more.
I absolutely love everything SAFE are doing in terms of standing up for those animals that oft get forgotten, particularly those in the agricultural sector. So if you're an animal lover, I highly recommend sending some of your volunteer time or annual donation budget to this absolutely wonderful charity. You can also shop in our Be Good Organics store here, and know that a portion of your purchase gets donated to them as well!
So without further adieu, let me pass you over to Hans for an insight into why he's so passionate about animals and a plant-based lifestyle. And of course no post would be complete without something delicious to whet your appetite, so make sure you check out his inspired recipe for the most incredible Nutty Ice Cream Cake too!
Why did you decide to turn to a more plant-based organic lifestyle?
I decided to go vegetarian when I was sixteen years old after a teacher at school told the class about factory farming. I didn't want to support any industry responsible for cruelty to animals. I later turned vegan after learning about the cruelty associated with the egg and dairy industries.
How has your health (physical and emotional) changed since then?
Giving up dairy was very beneficial for my health. I used to regularly use an inhaler for asthma related problems but now that I no longer consume dairy, these problems have disappeared. I feel good about the fact that I eat tasty, quality food without being responsible for the suffering and death of animals.
If you had to give someone 3 reasons why they should move to more plant-based products, what would they be?
To reduce animal suffering
To cause less environmental damage
What does a day on your plate look like:
Now, your favourite foodie indulgence...
A very hot vegetable Biryani from a top Indian restaurant (just have to make sure it is prepared without ghee).
What do you think the biggest fear or misconception is about going more plant-based?
That it is a boring type of diet and that it is nutritionally not balanced.
What's your approach to balance & moderation in life?
To live my life not just for my own benefit but to consider how my actions as a consumer impacts on others. That means still enjoying the good things life has to offer but not in excess (except for my 63 inch flat screen TV!)
You've been given permission to raid the Be Good Organics stock room - what's one foodie treat and one beauty product you'd nab?
Beauty product: Coola Sunscreen Sport SPF 35
Foodie product: A packet of Purple Kale Chips from Loving Earth
Would you like to share your favourite plant-powered recipe with us?
I absolutely love this recipe for Nutty Ice Cream Cake. It is super easy to make, and I have never met anyone who did not like it. The combination of sweet and salt works extremely well. Popular with adults and kids alike!
Note from Buffy: This is my interpretation of Hans' original Peanut Butter Cookie Ice Cream Cake. We devoured every slice so I hope you enjoy too! I used a batch of my Vanilla Bean Ice Cream as a base along with frozen bananas. My version is not overly sweet at all, so feel free to add one or two tablespoons of coconut nectar or date paste (1 cup dates blended with 1 cup hot water) to the filling sweeten. You can keep any spare date paste in a sealed jar in the fridge for up to three weeks.
Share your Nutty Ice Cream Cakes on Instagram and tag @begoodorganics and #begoodorganics. As always, I'll be sharing the best of your pics on my Instagram and Facebook!
Serves 10-12
All of the items below can be purchased from our online store, simply click on each ingredient link to add to your shopping cart.
Always use certified organic ingredients where possible
2 c caramelised buckinis (buckwheat cereal) OR crushed plant-based cookies
1/2 c virgin coconut oil (softened)
2 c vanilla ice cream
2 c banana (sliced and frozen)
1/2 c peanut OR almond butter
1/4 c chopped almonds
PS If you liked this recipe and interview, I'd love you to share it on Pinterest (hover over any of the images and click Pin It), Instagram (regram or make your own), Facebook or Twitter (hit the buttons up top). Thank you!
Buffy is the founder of Be Good Organics, and loves creating delicious yet simple plant-based whole foods recipes. Buffy also oversees our Be Good Organics online store, full of plant based goodies that she personally uses and loves. Sign up for our newsletter below to be the first to receive her weekly recipes.
These deliciously dark and mysterious tarts are just a little bit special, with a secret ingredient. Modestly sweet, with an earthy, nutty flavour- a lovely change from the usual fruity/chocolate affairs - give them a go, and fall in love!
These light and fruity muffins use one of my favourite fruits – feijoas! If you're a feijoa fan you'll love these (and if not, come to NZ to try them). Best of all, they have no added sugar – just the natural sweetness of feijoas, coconut, dates, and vanilla.
With the days getting colder and shorter, it's time to bring out the roast veg! This wonderful winter salad is spiked with the warming flavours of turmeric, cumin & smoked paprika. Pre-heat your oven and get ready for some tasty roasties.