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Hairloom and Caramel Hot
Presenting a very personal collection of our experiences and ideas in hair, beauty, fashion and food, Hairloom & Caramel is a salon and cafe housed in a comfortable and cozy environment. We offer hair and beauty services, as well as freshly-prepared home-cooked food, desserts and beverages. From the hand-decorated walls to the meticulously-sourced furniture and tableware, Hairloom & Caramel aims to create a homely atmosphere where guests can mingle and enjoy life's little pleasures.
Additional Details:
Featured reviews
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View all my reviews (103)
|Overall Rating:
Sweet & Hairy
Charming little cafe, with an off-beat, pretty decor featuring shabby-chic furniture and cute decorative elements. Doesn't have that contrived, poseur feel that most Singapore establishments suffer from.
I've tried the pasta with salmon and cream sauce, the chocolate cup cake and the coffee here. The prices are reasonable and the food is quite tasty. Considering how crammed and crowded other places get during the weekday lunch hour around the Shaw Leisure Gallery area, Hairloom & Caramel feels like an oasis of serenity. A pleasant place to escape the stress of the rat race.
I've never had my hair done at the salon before, but I had a colleague who did. His hair looked great. He had an impressive make-up done there for Halloween too.


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Join us and tell us what you think about the Beddington North TfL Major Scheme! Find out more here.Read more about Sutton – a focus for London's growth
Our toolkit supports community-led initiatives aimed at boosting the vitality of your high street.
Economy Watch is a report that assists current and new businesses with commercial insight into activity in Sutton's economy.
A video showcasing some of the opportunities and benefits within the London Borough of Sutton, and what Opportunity Sutton can help to deliver for investors and developers.
Contact the Opportunity Sutton team to find out how you can hire space in Sutton town centre.
Upcoming events in Sutton for you and your business.
Latest news from the Opportunity Sutton team.

subset: commoncrawl


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We're making MIT the hub of Virtual and Augmented Reality.
Here's how:
1. CREATING A COMMUNITY AROUND VIRTUAL and Augmented REALITY.
We're bringing together likeminded students who are excited about VR/AR/MR - sign up for our newsletter and check out our events to find your next chance to join us!
2. CONNECTING WITH The Experts.
We're bringing the industry titans to you and featuring the VR/AR leaders right here on MIT's campus.
We're encouraging what MIT does best - creating innovative companies.
Whether you are a free electron looking to join a VR startup or an established team, we're here to help.
Register your VR company to be showcased here. Or if you're just beginning your startup journey feel free to email us with questions. And since we're supported by the Martin Trust Center for MIT Entrepreneurship, we can always connect you to an expert if needed.


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Join Reality Kings! Download full-length 42min 23sec movie now!
Alyssa Lynn gets picked up by the milf hunters. It's her lucky day because she's about to get some young cock. She has her big, beautiful tits sucked on and her nipples licked. Then she gets her pussy pounded.
- dtr76ed
- : 8min
- : 1 Jul 2013
- Exclusive video


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Wednesday, August 28, 2013
Blue Diamond Almonds Artisan Nut-Thins Review
I participated in a campaign on behalf of Naturally Savvy for Blue Diamond Almonds. I received a product sample to facilitate my review. I was not paid in any form of cash for this posting. The opinions expressed are my own and were NOT influenced in any way.
School will be in full swing, by the end of next week. Parents will be making lunches for their children, so they will be looking for more healthy snacks and even snacks for after school. First thing that comes to mind for a snack is fruits and vegetables, second might be nuts or seeds. What about a snack that has brown rice, almonds and seeds in it?
About Artisan Nut-ThinsFor this review, I received three boxes of Blue Diamond Almonds Artisan Nut-Thins. All of them were a different variety. One has multi-seeds, then there's one with sesame seeds and the last one has flax seeds, which is my favorite. The most important thing, is all of them are Wheat and Gluten Free. They all make an excellent snack, especially with cheese or a healthy dip. They're crunchy and full of flavor! You can even top them with nut butters, tuna salad or even chicken salad. They're all delicious and would make a great snack for school lunches, after school snacks or any other time of the day! These crackers are rather addicting! I would highly recommend the Blue Diamond Almonds Artisan Nut-Thins!
Artisan Nut-Thins ~ Multi-Seeds
These are a great-tasting cracker and they're made with Multi-Seeds. They are made with brown rice, almonds, and six kinds of seeds, quinoa, flax, millet, amaranth, sesame, and black sesame. They have a distinct blend of flavors in a baked cracker, with a nice crunch. Serve them, with cheeses and spreads. They're perfect for dipping! One serving of 13 crackers have 3g of protein, 21g of whole grain, no cholesterol, no wheat, gluten free and only 130 calories!
Artisan Nut-Thins ~ Sesame Seeds
These cracker have an awesome flavor of sesame seeds. They also have brown rice and almonds to create a delicious baked cracker. The Sesame Seed variety is also gluten-free! They're perfect for appetizers, just combine them with cheese, dips, spreads and any other great combination you can think of. One serving of 13 crackers have 3g of protein, 3g of fiber, no cholesterol, no wheat and only 130 calories!
Artisan Nut-Thins ~ Flax Seeds
The health benefits of flax seeds have been around for more than 5,000 years. So, you know they must be healthy for you! They are made, with brown rice and almonds. Baked to a deliciously crunchy cracker! You can enjoy them with dips, spreads, cheeses, or straight from the box. One serving of 13 crackers have 3g of protein, 400mg of ALA Omega-3, no cholesterol, no wheat, gluten free and only 130 calories!
Bonny Sallee
Posted by Bonny Sallee at 8/28/2013 11:46:00 PM
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Canon EF 70-300mm f/4-5.6 IS USM Lens(Telephoto Zoom)
The EF 70-300mm f/4-5.6 IS USM Lens from Canon is a relatively light telephoto zoom lens offering a broad range of focal lengths from a single optic, with good optical quality and excellent autofocus performance from its ultrasonic (USM) motor. It has a circular aperture diaphragm to help create natural out-of-focus highlights, and its built-in image stabilizer allows you to handhold the lens at shutter speeds 3 steps slower than would otherwise be possible. This enables sharp imaging when shooting at telephoto lengths and even when shooting in low light. The two-mode stabilizer can be activated to only correct shake in the vertical axis for panning action when desired as well.
The lens' USM AF is very quick, smooth and silent, and it features a zoom lock button that keeps the lens safe and secure when not in use or when being used at the shortest 70mm focal length setting. The EF 70-300mm f/4-5.6 has Canon's "Super Spectra" lens coatings for ideal flare-resistance, and is ideal for travel, sports, and general photographic applications.
- A versatile telephoto zoom lens for both film and digital cameras, it provides a wide focal range that can encompass portraiture and of course magnify distant subjects. When used on an APS-C format camera, its equivalent focal length range is 112-480mm.
- Two-mode optical image stabilization compensates for camera shake and enables shutter speeds 3-steps slower than would otherwise be possible without incurring image blur. Mode 2 is best used when tracking a moving subject.
- An ultrasonic autofocus motor (USM) provides fast and silent AF action.
- UD (Ultra-low Dispersion) lens element reduces secondary spectrum aberration.
- Circular aperture diaphragm for natural-looking out of focus highlights.
- Canon Super Spectra lens coatings to suppress flare and ghosting.
- Zoom ring lock keeps zoom at 70mm and prevents lens 'creeping' during movement or even while shooting.
|7.62 x 14.22 cm
|Filter Thread
|Image Stabilization
|Focal Length
|70-300mm; Comparable APS-C 1.6x Focal Length: 112-480mm
|Maximum: f/4-5.6; Minimum: f/32-45
|Camera Mount Type
|Canon EF
|Format Compatibility
|35mm Film / Full-Frame Digital Sensor;Canon (APS-C)
|Angle of View
|34° - 8° 15'
|Minimum Focus Distance
|4.92' (1.5 m)
|Elements/ Groups
|Diaphragm Blades
|Maximum Reproduction Ratio


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The U.S. Department of Justice has signed off on maps redrawing Louisiana's congressional and Public Service Commission election districts.
The state Attorney General's office received word late Monday via an email notice on the deadline for a decision, spokeswoman Amanda Larkins said.
The congressional plan calls for six districts — one less than exists currently — which caused a lot of political jockeying in the Louisiana Legislature as various factions tried to protect their home bases.
Louisiana lost a congressional district seat because its population did not grow enough to keep it. The state suffered population losses in the wake of Hurricane Katrina in the New Orleans area.
The state must redraw the districts every 10 years based on the population shifts since the last census.
Neither the new congressional nor the PSC election districts will be used in fall elections. Elections with the new lines will not occur until 2012.


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The Dewalt Dwst1-70728 Tough system Ds250 is a heavy-duty 2 drawer storage system. It features 2 ball bearing sliding drawers, 8 removable cups within the top drawer for better organization of small to medium size tool bits and comes with side locking handles designed from biu-materials for added comfort and solid side plastic clips for secure stacking.
Key Features
Key Features
- Heavy-duty ball bearing sliding drawers
- Manufactured from 4mm thick reinforced outer casing
- Bi-material side handles for comfort
- Engineered plastic clips for stacking
|Unit Of Sale
|EDP code
You must be logged in to post a question.
No comments just yet - be the first!
Number of reviews : 2
Average rating : 5 /5
G. Derek
the 12/08/2016
5/ 5
have a few of theses, and have had to return a few, all returned were from different suppliers. the draws seem to jam = comes of runner. The one from Builder depot was one of the few that worked fine. So it not being in the original dewalt packing could mean its been on display or checked before sending. either way unlike many it works fine. good strong draw set. I have two sets of three fitted in my van. So far so good.
S. Michael
the 15/01/2016
5/ 5
Initial impression is good and sturdy, well pleased .
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|Everyday Lunch
|12pm - 3pm
|Sunday - Thursday Dinner
|6pm - 10pm
|Friday - Saturday Dinner
|6pm - 10:30pm
The mission is simple: serve fresh, locally sourced, affordable "proper" authentic desi Dhaba food - just as informative owners Az and Kirti have always enjoyed themselves. They want to take you on a journey around India - from north to south - showcasing some truly exquisite vegetarian, fish and meat dishes. This is somewhere you can pop in to clear your mind with a coffee or masala chai and watch the world go by, grab a Bombay Burger to go or Tandoori Salad at lunch, or tuck into a Grand Thali on a school night with some cheeky mid-week cocktails. Recognised for the National Tiffin Cup and voted as one of the Nation's favourite Indian restaurants.


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GREECE is on a knife-edge as it waits to see if Prime Minister George Papandreou can save his battered government - and the nation's economy - from collapse.
As world financial markets panicked over the prospect that continued violent protests could lead to the nation defaulting on its debt, Mr Papandreou moved yesterday to reshuffle his cabinet and seek a confidence motion in Parliament. At one point on Wednesday, Mr Papandreou had offered to quit if that would bring opposition leaders into a government of national unity.
In a televised address, however, he stood fast. ''Tomorrow [Thursday] I will form a new government and then I will ask for a vote of confidence. I will continue on the same course. This is the road of duty.''
The moves came after the fiercest day of protest Athens has seen in a year.
Demonstrators hurled fire-bombs, stones and wood at police outside Parliament. Some tore marble slabs out of historic Syntagma Square. Police responded with tear-gas and batons. Crowds chanted ''Thieves!'' and ''Resign! Resign!''
''They are traitors, they've plagued the country,'' said one unemployed woman of the nation's politicians.
Mr Papandreou failed to win support to pass new austerity measures this month, including tax rises, asset sales and spending cuts totalling €28 billion ($A37.6 billion).
Austerity was demanded by the European Union and the International Monetary Fund if Greece was to get more money from a €110 billion bailout fund. They fear Greece will default on its debt and spark a credit crisis that would also suck in Europe's other leaky boats - Spain, Ireland and Portugal.
The original bailout has failed. Despite tough cuts over the past year, unemployment has risen and youth unemployment is at 42 per cent.
Greece owes €300 billion, roughly 1½ times the country's annual output. Interest on its bonds - the money Greece must pay to investors who lend it money - yesterday soared close to 28 per cent, suggesting investors believed the country was near bankruptcy. It seems unlikely that Mr Papandreou can both hold the line on reforms and win over the opposition, or even his own socialist Pasok party.
Two of his MPs reportedly refused to vote for the package and others were uncertain.
A government source told The Irish Times: ''He's not resigning, but he is saying to [conservative leader Antonis] Samaras: 'You have to adopt my plan if you are to join a national government'.'' But the opposition said it would join a unity government only if the terms of the European Union bailout were renegotiated.
A second international bailout is being mooted, but Germany disagrees with the European Central Bank over the form it should take.
Berlin argues that private creditors must accept some losses, or else taxpayers would be paying the price while banks pocket the benefits.
But the ECB and several other countries believe markets would take fright, sparking a run on Greek banks and a deeper crisis.


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I'm just so taken with this amazing group. Here they are singing Byrd with a guess conductor - singing the piece that I fear is essentially impossible of our group at this point.
Kathleen Pluth, director of sacred choral music at St. Joseph Academy, S.T.D. (cand.) student at the Angelicum in Rome, hymn writer and translator | archive
Fr. Christopher Smith, S.T.D., pastor of Prince of Peace Catholic Church in Taylors, SC | archive
Mary Ann Carr Wilson, music director at St. Anne Church in San Diego, home of the summer Chant Camp.
Adam Wood, church musician and writer at Music for Sunday.
e-mail: firstname.lastname@example.com


text: The lower equivalent price reflects field level price -- gas prices that were 26% lower than in the fourth quarter of 2011.QEP Energy's combined derivatives portfolio contributed $83 million of EBITDA in the quarter compared to $66 million from the fourth quarter of '11, and $42 million from the first quarter of '11. The derivatives portfolio added $1.13 per Mcfe to QEP Energy's net realized price in the first quarter compared to $0.89 per Mcfe in the fourth quarter of '11 and $0.64 in the first quarter of '11. QEP Energy's combined lease operating transportation and production tax expenses were $114 million in the quarter, down from $122 million from the fourth quarter of '11 and up from $99 million in the first quarter of '11. Read the rest of this transcript for free on seekingalpha.com


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A three-week operation to crack down on violence in Atlantic City resulted in 58 arrests and the seizure of thousands of dollars in drugs and 12 guns.
At least one gun was recovered during nine of the 12 outings that involved the Police Department's vice, intelligence and tactical teams along with the Atlantic City Task Force, Lt. James Sarkos said.
"One statistic that can't be captured is the crimes that were deterred and did not occur as a result of this targeted enforcement in violent areas," Capt. Tim Friel said.
In addition to 11 handguns and a shotgun, police also recovered $3,620 worth of heroin, $370 each of cocaine and ecstasy and $235 in marijuana.
"This is a great example of the Atlantic City Police Department and the Atlantic City Task Force pooling our resources in an effort to deter crime and increase the quality of life for Atlantic City residents," Sarkos said.
The Atlantic City Task force is overseen by the state Attorney General's Office and combines city police with officers from county, state and federal agencies.
Those arrested for unlawful possession of a weapon were Thomas Lahart, 27, of Philadelphia; Jared Baylor, 22, of Camden; Joshua Burton, 21, and Ibn Abdullah, 19, both of Pleasantville; Shawn Smith, 20; Robert Morgan, 21; Christopher Weldon, 26; and a 17-year-old juvenile, all of Atlantic City; and Rodney Marshall, 21, of Galloway Township.
Abdullah and the juvenile both were charged with having two weapons, along with possession of hollow-point bullets and possession of stolen property.
Baylor, who previously served prison time for drug and weapon offenses, was additionally charged with resisting arrest, obstruction of justice and possession of a weapon by a convicted felon.
Smith was also charged with possession of a weapon by a convicted felon, possession of ecstasy and possession with intent to distribute.
Morgan faces additional charges for possession of a stolen firearm, possession of a weapon by a convicted felon, possession of heroin, possession of crack cocaine, possession of a weapon while committing a drug offense, and two counts each of possession with intent to distribute and possession within 500 feet of a park.
Also facing additional charges were Burton, for resisting and obstruction, and Marshall, for possession by a convicted felon and possession of hollow-point ammunition.
Police arrested and charged 49 others with drug and other offenses.
Contact Lynda Cohen:
Follow @LyndaCohen on Twitter


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Responsible for general office coordination.
Interacting with clients and visitors.
Scheduling of meetings and appointments.
Performing general clerical duties including bookkeeping, copying, mailing and filing.
Budgeting, monitoring and control of administrative cost.
Assisting HR in coordinating general administrative policies and procedures,
general office administration, document management, general services.
Scheduling of meetings and appointments, receiving of letters and other statutory documents on behalf of the CEO.
Supervising Administrative Support Personnel; assigning, reviewing and evaluating their work.
Collation, compilation and evaluation of sales report, petty cash, debtors and
Review and approval of loading orders, purchases, vouchers and other financial
Liaising with law enforcement agencies such as MAN, Police, Immigration etc.


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Union Minister for Urban Development and Information and Broadcasting Venkaiah Naidu termed as 'kiddish and immature' AICC Vice-President Rahul Gandhi's statement that there would be an earthquake if he was allowed to speak on the demonetisation issue in Parliament.
During an interaction with this newspaper Mr Naidu sarcastically asked: "Has he (Rahul) has gone to Meghalaya where the earthquake took place today?" Mr Naidu, who was here to take part in "Kalyana Karnataka Vikas Yatre" organised by Kottala Basaveshwara Shikshana Samsthe went on ask, "Who has prevented him (Mr Rahul) from speaking in the Lok Sabha? It's known to everybody that he comes to the Lok Sabha on a vacation. And because of his speeches the Congress has been shrinking in size. The party which many times had over 350 members has now a pitiable strength of 44. The major credit for bringing the Congress to this state should go to Mr Rahul. First let him take care of his party before thinking of causing an earthquake in Parliament".
While defending the decision of PM Modi on demonetization as a revolutionary step, Mr Naidu came down on the Opposition for 'willfully obstructing' proceedings in Lok Sabha. "When a chemotherapy is given for cancer afflicting the country's economy, there is bound to be some pain. But after some time the pain will subside and the patient would be cured". Earlier speaking at the function, Mr Naidu called upon people to lend r support to the "Modi (Making of Developed India ) Abhiyaan" aimed at cleanising the country of black money and corruption.


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LAS VEGAS (AP) Guests evacuated three floors of the Bellagio casino resort Tuesday morning after a mattress fire left one man burned and others complaining of smoke inhalation, officials said.
Sprinklers contained the 5:50 a.m. fire to a single 26th-floor room, but smoke and water damaged nearby areas, Clark County Fire Chief Steve Smith said.
The guest in the room where the fire was located was burned on the arm and was taken to a hospital, fire spokesman Scott Allison said. Several other people were treated for smoke inhalation at the scene, he said. No firefighters were hurt.
Fire and hotel officials said they were still investigating the fire.
Guests on the floor were evacuated as crews cleaned up. Some guests from the 25th and 27th floors of the 3,000-room tower also evacuated voluntarily, said Gordon Absher, spokesman for MGM Mirage Inc., which owns the Bellagio. He said those guests were allowed to return to their rooms later in the morning.
Allison said fire officials also were investigating a fire Monday night in a 14th-floor mechanical room at the Venetian hotel-casino. Both hotels are on the Las Vegas Strip. A pile of large air filters caught fire, but the blaze was doused by sprinklers, he said. No injuries were reported.
Copyright 2008 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
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Rustic Pork Ragu
READY IN: 3hrs 30mins
Recipe by JackieOhNo
Real Simple Magazine October 2004
Top Review by Ma Field
I started with porchetta and added the tomatoes, more onion and garlic to make this yummy dish. I wanted it to have more heat, like a puttanesca maybe. DH loved how thick and hearty is was. Used a combination of ziti and bowtie pasta to hold it up. Wonderful one pot dish, maybe a little heavy for summertime. I'm looking forward to having it on a chilly winter's night! Made for Daffy Daffodils ZWT4
See Discussion:1 Review
Ingredients Nutrition
- 2 tablespoons olive oil
- 1 (2 1/2 lb) boneless pork loin
- 2 teaspoons kosher salt
- 1 teaspoon fresh ground black pepper
- 1 large onion, chopped
- 2 sprigs fresh rosemary, leaves picked and chopped
- 4 garlic cloves, chopped
- 1 (35 ounce) cancrushed tomatoes with juice
- 1 lb pappardelle pasta, cooked
- grated romano cheese, to taste
Directions See How It's Made
- Heat the olive oil in a Dutch oven over medium-high heat. Season the pork with the salt and pepper and sear on all sides until golden brown, 3 to 4 minutes per side. Remove the pork; set aside.
- Add the onion, rosemary, and garlic and cook, stirring, until fragrant, about 2 minutes.
- Add the tomatoes and their juices and stir with a wooden spoon, scraping any bits of pork stuck to the bottom of the pot.
- Return pork to the pot. Bring the liquid to a boil, then reduce heat. Cover the pot tightly and simmer on the stovetop until the pork is tender enough to fall apart, 2-1/2 to 3 hours.
- Remove the pork and, when it is cool enough to handles, shred it into bite-size pieces. Add the shredded pork back to the stockpot. Simmer until hot.
- Serve over the pasta with the Romano sprinkled on top.


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Viewing 2 posts - 1 through 2 (of 2 total)
- November 1, 2012 at 2:53 pmReply
I tried to grab a video from vimeo, and once it downloads on your site, the only option I have is to download an MP3 file. I was wondering why it doesn't allow me to download the video itself, say as in MP4 format?December 19, 2012 at 9:12 amReply
Hello, belle61.
The original video quality determines the output video quality. Sometimes, you will get several video qualities for downloading. And it happens that you only have one choice, download video in MP4 or FLV. I made a test to grab vimeo video with video grabber, it provides me two buttons. Right-click on the first button, choose an output folder, then you can save vimeo video to your computer in MP4 format. I have downloaded the video off successfully. Please refer to the instruction in this picture.
Viewing 2 posts - 1 through 2 (of 2 total)


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Browse By Person: Huang, Wei-Che (Darren)
|Up a level
Group by: Item Type | Date
Jump to: Journal Article | Conference Paper | Conference Item | QUT Thesis
Number of items: 10.
Journal Article
Itakura, Kalista, Clarke, Charles, Geva, Shlomo, Trotman, Andrew, & Huang, Wei Chi (2011) Topical and structural linkage in Wikipedia. Lecture Notes in Computer Science: Advances in Information Retrieval - Proceedings of the 33rd European Conference on IR Research, ECIR 2011, 6611, pp. 460-465.
Huang, Wei-Che (Darren), Geva, Shlomo, & Trotman, Andrew (2009) Overview of INEX 2008 Link the Wiki Track. Lecture Notes in Computer Science, 5631, pp. 314-325.
Conference Paper
Huang, Wei-Che (Darren), Geva, Shlomo, Itakura, Kelly, & Trotman, Andrew (2011) Mobile applications of focused link discovery. In Cunningham, Sally Jo, Scholer, Falk, & Thomas, Paul (Eds.) Proceedings of the Sixteenth Australasian Document Computing Symposium 2011, Royal Melbourne Institute of Technology, Australian National University, Canberra, ACT, pp. 26-30.
Huang, Wei-Che (Darren), Trotman, Andrew, & Geva, Shlomo (2009) A Virtual Evaluation Track for Cross Language Link Discovery. In SIGIR 2009 Workshop on The Future of IR Evaluation, 23 July , Boston MA.
Huang, Wei- Che (Darren), Trotman, Andrew, & Geva, Shlomo (2007) Collaborative Knowledge Management: Evaluation of Automated Link Discovery in the Wikipedia. In 30th Annual International ACM SIGIR Conference on Research & Development on Information Retrieval, 23-27 July 2007, Amsterdam, Netherlands.
Huang, Wei-Che (Darren), Roe, Paul, & Wong, On (2006) Design and Implementation of a Mobile Wiki. In Barolli, L, Abderazek, B, Grill, T, Nguyen, T, & Tjondronegoro, D (Eds.) Frontiers in Mobile and Web Computing: Proceedings of MoMM2006 & iiWAS2006 Workshops, 4 - 6 December 2006, Indonesia, Yogyakarta.
Huang, Wei-Che (Darren), Roe, Paul, & Wong, On (2006) Pocket RikWik: A Mobile Wiki Supporting Online and Offline Collaboration. In Treloar, A & Ellis, A (Eds.) Proceedings of AusWeb 06: Making a Difference with Web Technologies, 1-5 July 2006, Australia, Queensland, Noosa.
Conference Item
Huang, Wei-Che (Darren), Trotman, Andrew, & Geva, Shlomo (2009) The importance of manual assessment in link discovery. In 32nd international ACM SIGIR conference on Research and development in information retrieval, 19-23 July, Boston MA.
QUT Thesis
Huang, Wei-Che (Darren) (2011) Evaluation framework for focused link discovery. PhD thesis, Queensland University of Technology.
Huang, Wei-Che (Darren) (2007) Design and implementation of a mobile wiki : mobile RikWik. Masters by Research thesis, Queensland University of Technology.


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Without a battery strong enough to crank it, even the best of engines can't go anywhere. Make sure that the battery is filled to the level of the plates with electrolyte. If it is not up to the proper level (just above the vertical plates) add distilled water, which is available at any auto supply store. The average battery lasts between 2-5 years, but with periodic attention to the electrolyte level most would last much longer.
For more information on battery service, please refer to .


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Elite Autumn Service Apartments
Call us 1800-300-2400-1 (Toll Free) and Get additional Discount upto 50% for this Hotel.
You are getting lowest possible rate for this hotel
- About Hotel
- Reviews
About Elite Autumn Service Apartments
Elite Autumn Service Apartment is a budget property located in Pune. This superb property offers a comfortable stay to guests at affordable rates. Guests can stay in the modishly decorated rooms equipped with modern amenities to ensure a pleasant stay. Breakfast services are offered guests can start their day on a healthy note. Guests can also avail round-the-clock room service offered by the polite and hospitable hotel staff. Guests can also savor the delectable dishes served at the in-house restaurant.
Checkin Time: 1200 pm
Checkout Time: 1200 pm
Hotel Amenities
- Newspaper
- Internet Access
- Luggage Storage
- Video Game Console
- Restaurant
- Smoking Rooms
- Medical Services
- Tea Coffee Maker
- Room Service
- Parking
- Travel Counter
- Breakfast Services
- Airport Transportation
- Laundry Facilities
- Front Desk
- Multi-line Phone
- Temperature Control
- Slippers
- Video-game Console
- Refrigerator-Room
- Iron/ironing Board(on Request)
- Telephone-Room
- "Bottle Opener
- Shower Caps
- Bottle Opener
- Smoking Rooms
- Premium TV Channels
- Bottled/drinking Water
- Tea Coffee Maker
- Toothbrush/Razor On Request
- Television-Room
- Wakeup-calls
- Attached Bathroom


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Two thirds of the world's population have no access to safe and affordable surgery.
A major new Commission on Global Surgery, published today in The Lancet. and launched at a day-long symposium at the Royal Society of Medicine in London, suggests that the number of people worldwide who are unable to access basic surgery and anaesthesia is more than twice as high as previously thought.
The Commission was written by a group of 25 leading experts from across the fields of surgery and anaesthesia, with contributions from more than 110 countries. The report examines the case for surgery and anaesthesia care as an integral component of health care, focusing on low- and middle-income countries (LMICs), where need is greatest.
"In the absence of surgical care, common, easily treatable illnesses become fatal. The global community cannot continue to ignore this problem – millions of people are already dying unnecessarily, and the need for equitable and affordable access to surgical services is projected to increase in the coming decades, as many of the worst affected countries face rising rates of cancer, cardiovascular disease, and road accidents." Andy Leather, one of the Commission's lead authors, from King's College London.
Despite the gross disparities in access to safe surgical care worldwide and resulting deaths, surgery has remained a peripheral concern in global health discourse, often considered too complex and too expensive to address. Its central role is now gaining recognition, underscored by research which suggests that as much as 11–30% of the global burden of disease requires surgical care or anaesthesia management, or both.
The Commission's five key messages are presented as follows:
In addition, the Commission also provides a set of indicators and recommendations to improve access to safe and affordable surgery and anaesthesia, and a policy template for national surgical plans. It is accompanied by a substantial body of original research which was used to inform the Commission's findings, and is published in the journals Surgery and The Lancet Global Health.
Find out more about THET's work to strengthen emergency and essential surgical care and anaesthesia through health partnerships here


text:
How to Repair rear disc brakes on a 1998-2004 Dodge Intrepid
Good brakes are essential to safe driving. Keep your brakes in top condition by replacing the discs and shoes before they wear down. You can do this auto repair yourself by following the instructions in this video, which demonstartes the procedure on a 1998-2004 Dodge Intrepid.


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As is true of many photographers, I knew what I wanted to be at the age of 16. Now, many years later, I thrive in providing high quality architectural photography and interior photography. The work is challenging and rewarding. I am never happy unless my clients are happy.
I encourage you to contact me if you have any questions or feedback. I hope you enjoy my site. Thank you for coming!
Clients include:


text:
This easy-care machine washable uniform shirt is constructed of polyester fabric with a tighter weave than other uniform shirts for enhanced moisture wicking to ensure you stay drier and more comfortable. Premium details like sewn-in military style creases, button down epaulets and permanent collar stays give this shirt a crisp, professional appearance.
Sizing is not right, the size tag says 17 1/2 but it's more like a 191/2..
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While most shirt sizes are known by neck size ad sleeve length, your system drives me crazy --- any chance you can revert to neck & sleeve length???
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text: My daughter had a ski race in Craftsbury and the Kimball House was such a convenient location, just 20 minutes south of the ski center in Hardwick, and really affordable. Being in Hardwick also gave us the chance to dine at Claire's--such a fabulous restaurant using great local producers. Kimball House is totally charming but not overdone. The rooms are... More


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The Zeiss Colored Shims are a set of 11 color-coded spacers of varying thickness designed for use with a Compact Prime CP.2 interchangeable-mount lens. When changing the mount (for example, from a PL to an F), it's crucial to have the proper flange focal distance. These shims fit inside a groove in the disassembled lens barrel and can be stacked, using a flat-bladed screwdriver or tweezers, in any combination to achieve the required thickness. These shims are in addition to those that come with the various Interchangeable Mount Sets.
Shim Colors & Thickness:


text:
Love them or hate them, there's no denying that cranberries are an integral part of our holiday dinners. But they aren't just for holidays.
From personal experience, it seems to be an acquired taste for some. That's OK, but there are lots of ways to make cranberries more palatable for those who don't care for them.
Whether it's in a molded salad or, in this case, a sauce, maybe it's time to give it another try.
If you have a bag or two of cranberries and turkey or ham slices left over from the holidays in your freezer, the following recipe just might help out. Serve Cranberry Pineapple Sauce with turkey sandwiches. A couple of spoonfuls will do wonders for the sandwich or, if you prefer, just spoon it over a few turkey or ham slices.
It's also a great alternative for those who don't like gravy with turkey or ham. It can be made ahead of time and stored in the refrigerator.
Julie Kay is a columnist for The Advocate. She can be reached at firstname.lastname@example.com.


text:
It's time to shine! KUMA new eyecatchers will make sure that the spotlight is on you! This Wonderfully luxurious yet quirky butterfly brooch is covered with Swarovski crystals, that will twinkle all night long…
Butterfly was seen in ancient cultures as the personification of a person's soul. Our hand-made bow-tie Butterfly brooches enable you to experience this old tradition in a modern setting. Choose the one that best captures the essence of your soul.
Butterfly brooches also make an excellent gift - a truly eye-catching statement for expressive types!
All Butterfly brooches are crafted by skilled artists using real leather and expressive colours.
We love to upcycle! All butterflies are made of leftover leather from soft furniture manufacturers, therefore giving new life to the production waste that would otherwise be left unused or thrown away.
Materials used: Swarovski crystals, Real leather and brooch needle.
The product comes in a black gift box.


text:
Those long awaited Black Friday ads, sales, and deals are finally here. Black Friday shopping is one of the most popular traditions in the United States today. This particular shopping day occurs on the Friday that immediately follows the official Thanksgiving holiday.
Originally, the residents in the area of Philadelphia deemed this Friday as "black" because there was typically a high level of traffic that was experienced on this day. However, retailers then took up the term because this was the day in which most stores went from being "red" in numbers to being "black" in numbers, meaning that they were experiencing a profit.
Here, you will learn about Black Friday and how many are starting to convert to online shopping on this day. In the United States, once Thanksgiving has passed, it typically means that the mark of the holiday season shopping has started. This tradition is nearly as old as the season itself.
Retailers start to drop the prices on numerous items in their stores, and consumers rush out to get the best deals possible. Stores everywhere prepare for this event many months in advance, decorating the store, determining prices, and other activities. Typically, these stores work to open their doors really early and run sales up until about 11 AM.
In some instances, the stores may offer the sales all day long and remnants of the sales may last a few days afterwards. Unfortunately, for shoppers, the stores are often busy and uncomfortable, so many are starting to shop online for the Black Friday ads.
Black Friday online has become quite popular among those who want to avoid the hectic, busy stores on the day immediately following Thanksgiving. There are several popular retailers that offer the same deals to consumers on the internet as they do in the stores that are around the nation. There are several people who actually prefer this particular form of shopping on Black Friday, rather than going in person to the store.
If you shop on this particular day, and want to avoid all of the traffic on the roads, the elbow to elbow shopping, and walking a mile just to get to the store of choice because of the fact that you can't find any parking spaces, then shopping online may be right for you!
The following details some of the tips that several individuals have shared when it comes to Black Friday virtual shopping tips:
As you can see, Black Friday is quite popular when it comes to American consumers. As a matter of fact, this day is a tradition among most shoppers. If you are looking to get the best Black Friday deals shopping online may be right for you.
It was only a few years ago, you would have to be in the United States to get the great bargains and save big on gift shopping. Now, through online shopping the world enjoys America's Black Friday and Cyber Monday.
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text:
Search Results: 'American Grape Training'
American Grape Training (Illustrated)
eBook (ePub): $1.99
This book has grown out of an attempt to teach the principles and methods of grape training to college students. I have found such teaching to be exceedingly difficult and unsatisfactory. It is... More > impossible to firmly impress the lessons by mere lectures. The student must apprehend the principles slowly and by his own effort. He must have time to thoroughly assimilate them before he attempts to apply them. I therefore cast about for books which I could put before my class, but I at once found that there are very few succinct accounts of the subjects of grape pruning and training, and that none of our books portray the methods which are most largely practised in the large grape regions of the east. My only recourse, therefore, was to put my own notes into shape for print, and this I have now done. And inasmuch as all grape-growers are students, I hope that the simple account will find a use beyond the classroom.< Less
American Grape Training An account of the leading forms now in use of Training the American Grapes
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The drive towards "small is beautiful" developments is being boosted by crowd funding, a form of financing that raises modest amounts of cash from thousands of individuals to provide a pool of money that builders can use.
Funding Circle, one of the new marketplace lending platforms, raised £100 million last year, helping to build more than 600 homes in the capital, including a seven-apartment scheme in Ealing by developer Uplift Property, which made use of a £2.1 million loan financed by 30,198 investors.
Typically, the schemes have fewer than 20 homes and appeal to buyers who want to be part of a community with more individuality.
"They would rather be one of 10 than one of 100," says Jamie Gunning, director of property consultant CBRE, which reports there are more such London projects than at any time in living memory.
Developers and estate agents say discreet yet glamorous developments have more cachet and better resale values than larger projects.
Image gallery: crowd-funding boosts London's new boutique developments
Image gallery: crowd-funding boosts London's new boutique developments
1/17 Westminster
From £950,000: Chapter Street, in Westminster, has 31 flats designed in the Art Deco style of the original building (scroll right...)
2/17 Westminster
From £950,000: the building backs on to Vincent Square, a 13-acre green space with playing fields owned by Westminster School. Call 0844 8114321.
3/17 Westminster
From £975,000: Great Minster House is a new development close to the Houses of Parliament (scroll right...)
4/17 Westminster
From £975,000: situated opposite the Home Office, the building echoes the area's Edwardian mansion blocks with parquet floors and high ceilings. There is also 24-hour porterage. Call 0844 811 4334.
5/17 St James's, London
£34.95From £2 million: Beau House, in Jermyn Street, St James's, is names after Beau Brummell, the celebrated arbiter of men's fashion in the 18th century (scroll right...)
6/17 St James's, London
From £2 million: The handsome building has an anonymous-looking entrance that opens into an opulent lobby with a gilded coffered ceiling, above which are eight apartments completing in 2016.
7/17 St John's Wood
From £3.295 million: 15 Grove End Road is a small scheme of four apartments plus a duplex penthouse. Arrive by car and, at the press of a button, the ground opens up to transport the vehicle to a subterranean car park (scroll right...)
8/17 St John's Wood
From £3.295 million: flats at Grove End Road are within close proximity to Lord's Cricket Ground and Regent's Park. Call 020 7409 9001.
9/17 Highgate
£6.25 million: there are 15 two- and three-bedroom flats at One Highgate in N6 (scroll right...)
10/17 Highgate
£6.25 million: this three-bedroom apartment at One Highgate offers the ultimate in luxury living. Call 0208 731 9500
11/17 Covent Garden
From £3.5 million: situated next to Theatre Royal Dury Lane, The Tavistock is a converted Edwardian office building (scoll right...)
12/17 Covent Garden
From £3.5 million: this Edwardian building has been split into four apartments, each with a lobby and direct lift access from the tasteful entrance foyer. Call 020 7240 2255.
13/17 Putney
£1.375 million for a three-bedroom apartment: Upper Lawn is described as a "21st century take on a traditional Putney mansion block", a 25,000sq ft of two-, three- and four-bedroom lateral apartments and a large shared garden. Call 020 3324 9223
14/17 Holborn
From £895,000: The Grays, in the Holborn legal zone, has 13 apartments (scroll right...)
15/17 Holborn
From £895,000: The Grays is within walking distance of London's financial district and famous West End. Call 020 7182 2394
16/17 Shackleford, Surrey Hills
Nestled within Surrey Hills are detached homes in Shackleford, close to Godalming and Farnham (scroll right...)
17/17 Shackleford, Surrey Hills
Each house has been individually designed with spacious, bright interiors and landscaped gardens. Call 01483 415252
The "Great Inversion": city-centre living returns
The jump in the number of boutique homes is also linked to the revival of city-centre living. For 10 years, London has been undergoing a form of what American commentators call the "Great Inversion" — the return of people, housing and highly-paid jobs to city centres.
Often, buyers work in the City or the creative sector. They are not first-time buyers, and include downsizers whose kids have flown the nest and who want to enjoy an interesting home and the London lifestyle.
Developers in this mould are not searching in the traditional rich enclaves for land, but turning to areas such as Westminster, Covent Garden and Holborn, sometimes with selling prices starting from £500,000.
Buyers who want bigger developments tend to have different needs and motives. The package of amenities on offer — such as a gym, spa, underground parking, on-site bars and eateries — is considered important by them, whereas small-site buyers tend to be more interested in the architecture of a building and the quality of the interior design.
"We take on small, more complex sites that volume house builders are not interested in, to create highly individual homes," says Richard Leslie, boss of niche developer Dukelease, which has a handful of projects under way in the West End.
"Often the homes are above street-level shops. We select retailers to make sure there is a good fit with what residents want."
Niche homes boom
Beau House in Jermyn Street, St James's, is named after Beau Brummell, the celebrated arbiter of men's fashion in the late 18th and early 19th centuries. The handsome building has an anonymous-looking entrance that opens into an opulent lobby, above which are eight apartments completing next year, priced from £2 million.
Covent Garden's numerous over-the-shop projects include The Tavistock, next to Theatre Royal Drury Lane. Here, an Edwardian office building has been split into four apartments, each with a lobby and lift access from the foyer. Prices from £3.5 million. Call CBRE on 020 7240 2255.
The Grays, in Holborn's legal zone, has 13 flats priced from £895,000. Call 020 7182 2394.
"These buildings tend to attract owner-occupiers rather than buy-to-let investors," says Matt Cobb of Hatton Real Estate, which operates in City-fringe districts.
A crop of boutique projects includes a Victorian "weights and measures" warehouse in Rosebery Avenue, EC1, that is being split into eight high-ceiling apartments priced from £795,000, while a Camden pub conversion project, in Pakenham Street, has four apartments priced from £495,000. Call 020 7101 2020.
"I looked at more than a dozen larger developments, but found them too overwhelming," says Christine Jenkins, 40, a lawyer who lives in a 10-apartment block in Bermondsey. "I moved in about a year ago and have got to know all my neighbours — some have become friends."
Character counts: period buildings with contemporary design
Jo Eccles, founder of property search agency Sourcing Property, says there is huge appetite for small developments. "Often they are listed period buildings and, when imaginatively refurbished, provide a wonderful mix of character and contemporary design," she adds. "Usually, homes are bought by local people rather than sold at roadshows overseas to investors."
The address One Highgate says everything about the status of this boutique scheme of 15 homes on the slopes of north London. Big, lateral flats in a handsome red-brick mansion block with underground parking, a swimming pool and concierge cost from £1.6 million. Call 020 8458 7311.
St John's Wood is an unblighted residential district with a high street full of cafés, boutiques and bistros bordering Regent's Park. At 15 Grove End Road there are five apartments, each with a terrace. Arrive by car and, at the press of a button, the ground opens up to reveal a subterranean car park. Prices from £3,295,000. Call Savills on 020 3043 3600.
The Villas in nearby Maida Vale are eight modern townhouses clad in mellow brick and bronze. Set behind artist-designed gates in a pretty courtyard, the homes have large roof terraces and basement media rooms. From £1,395,000. Call 020 7724 4724.
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text:
FoB - Social Media Panel
Wednesday, April 29, 2009
So yes, like a total dork I took notes at all of the panels I attended at the Festival of Books. This is because I am so not an auditory learner, and I tend to forget things as soon as I hear them. So over the next few days I will be sharing all of my (somewhat disjointed) notes from the various panels.
First up, the Social Media panel. This was the first panel I attended on Saturday morning. Moderated by Andrew Nystrom, from the LA Times, this panel consisted of Wil Wheaton (of Star Trek fame, and who is evidently one of the hottest things on Twitter…since I'm a total rube, I was clueless not only of his fame but even of his existence), Otis Chandler (founder of Goodreads) and Sara Wolfe (dance columnist for the LA Times and a really good example of the stereotypical ditsy artsy persona).
Given the topic, there was a big push to tweet during this panel. Unfortunately, I had no internet connection, so no tweets from me. Which is okay, because I'm a lousy multitasker, anyway.
Otis Chandler started off by stating that reading is broken. He said when it comes to reading your ideas are locked in, not shared. Goodreads tries to change that…he sees it as the equivalent of discussing American Idol at work the next day. He wants to create social peer pressure to read.
Wil Wheaton responded to the idea that social media contributes to dumbing down and short attention spans. He sees Twitter as a communication tool…it's like instant messaging, but you choose what you want to read and respond to and link to. He uses social networking and self-publishing to reach more people. He also mentioned that he heard Twitter grew by 90% in March.
Sara Wolfe talked about Facebook and how she uses it to connect to the dance community. She also talked about constellations and constellating and how she really didn't understand Twitter…at which point I'm afraid I tuned her out. Oh…except at one point she mentioned her colleague who gives tests on Twitter. Huh? Her predilection for the word constellation in various real and made up forms was too distracting. In fact, she sent our group into giggles at one point. She also talked about the dance community and dropped names as if we all knew what she was talking about. Which we didn't. If we could have voted her off the island, she would've been gone.
Wil Wheaton mentioned that it is important to remember that what you put online is there "until the lights go off on Planet Earth." I thought this was an excellent point.
Otis Chandler said he started blogging to remember what he had read, which I so identify with. He went on to say that unlike watching a movie, reading is a commitment. He sees Goodreads as an addition to social media. With the "what page are you on" feature, you can share thoughts about a particular part of a book. Wil added that as an author, he likes this feature, because then he can see what pages people are talking about in his books. You no longer have to be in the same room with someone to have a connection and share your thoughts.
Andrew Nystrom stated that it is important to listen to others on social media and remember that it is not all about you. Wil added that the users own social media, not the marketers. The people who ruin it will show up sooner or later, so it's up to the users to block or not follow or report spam.
I really enjoyed this panel. I especially liked listening to Otis Chandler share his thoughts on Goodreads, since I use it (sporadically). Wil Wheaton was also quite entertaining; I can see why he is such a popular figure. Like I said earlier, if we could have just voted Sara Wolfe off of the island, it would have been even better.
For other notes and thoughts on this panel, check out the posts from my fellow attendees:
Lisa at Books on the Brain
Trish at Hey Lady!
Tracy at Shelf Life
Wendy at Musings of a Bookish Kitty
Natasha of Maw Books
Florinda at The 3 R's Blog
Amy of My Friend Amy


text: One of the most common ways of using an anticipation guide in an English classroom is to provide a series of belief statements that are aligned with the material and, most commonly, students are asked to respond to them by agreeing or disagreeing with the statements in some fashion (either by short answer, ranking, yes/no, moving to a location in the classroom, etc.). Below is an example of the traditional anticipation guide I have used with To Kill a Mockingbird. Read more


text:
Across the Board Lace Dress
style #AGG97671Add to Crushes
Across the Board Lace Dress
Colour: pink
EU Size: 36
- 36
- 38
- 40
It's no contest, but if it were, this dress would win every time (just sayin'). The Across the Board Dress comes in lace and features a halter, cold shoulder, mini silhouette, eyelash lace trim, and strappy detailing.
Details and CareFabric: 100% Polyester. Machine wash. Model wears US Size 4 UK Size 8.
Size Chart
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Delivery option Delivery times Delivery cost Republic of Ireland Super Saver Delivery €4.00 Up to 6 working days Republic of Ireland Standard Delivery €5.00 Up to 4 working days Republic of Ireland Next Day Delivery €6.00 Next Day if ordered by 1pm Monday to Friday Dublin Only Next Day Delivery €6.00 Next Day if ordered by before midnight Monday to Friday European and International Delivery €6.00 Up to 7 working days. International 5-14 working days
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text:
For sale by Pius - VERIFIED SELLER VERIFIED12 Feb 10:06 amAmuwo Odofin, Lagos
Used less than 10 months
Power steering and glass (front)
Black Leather interior
A/C working
Original Peugeot wheel cover
Original Clarion stereo with CD loader option
Jack, wheel spanner and spare tyre still intact.
Stay safe!
Watch out for:


text:
Extremely flammable, gas under pressure, vapours may cause drowsiness and dizziness, causes serious eye irritation!
This 'O-Paint-free' paint treatment enables you to remove all respray work and lay the original paintwork of any vehicle bare. In addition to this product a small paintbrush, some cellulose thinners, a couple of clean dry cloths or paper wipes and a refillable pump-aerosol would also be useful although not necessary!
Instructions : The area of paintwork to be treated must first be washed with warm soapy water, rinsed and left to dry once cleaned. The paint treatment liquid can then be liberally and evenly applied to the paint you wish to remove and left for at least two minutes to soak in, but not longer than fifteen! The layer or layers of unwanted paint can then be removed by first dipping the brush in the cellulose thinners and gently brushing it away. Alternatively, for larger surfaces the thinner can be applied using the pump-aerosol and then wiped clean with the cloths containing thinner.
SIP- TIP : Once the original paintwork has been successfully revealed it requires immediate polishing and sealing!


text:
Intervention Review
Antipsychotic switching for people with schizophrenia who have neuroleptic-induced weight or metabolic problems
Editorial Group: Cochrane Schizophrenia Group
Published Online: 8 DEC 2010
Assessed as up-to-date: 26 FEB 2008
DOI: 10.1002/14651858.CD006629.pub2
Copyright © 2013 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.
Database Title
Additional Information
How to Cite
Mukundan A, Faulkner G, Cohn T, Remington G. Antipsychotic switching for people with schizophrenia who have neuroleptic-induced weight or metabolic problems. Cochrane Database of Systematic Reviews 2010, Issue 12. Art. No.: CD006629. DOI: 10.1002/14651858.CD006629.pub2.
Publication History
- Publication Status: Edited (no change to conclusions)
- Published Online: 8 DEC 2010
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text:
Small G proteins in peroxisome biogenesis: the potential involvement of ADP-ribosylation factor 6
Peroxisomes execute diverse and vital functions in virtually every eukaryote. New peroxisomes form by budding from pre-existing organelles or
Here we show that all viable
These observations suggest that Arf6 is a key player in mammalian peroxisome biogenesis. In addition, they also lend strong support to and extend the concept that specific Arf isoform pairs may act in tandem to regulate exclusive trafficking pathways.
Peroxisomes are a diverse group of organelles which accommodate many activities related to lipid metabolism. In mammals, these organelles harbor a number of essential metabolic functions including ether phospholipid biosynthesis, fatty acid α – and β-oxidation, and glyoxylate detoxification
Studies in different model systems have demonstrated that the Pex11p family of peroxisomal membrane proteins (PMPs), a select set of dynamin-related proteins (DRPs), and Fis1 and Mff – two putative adaptors for DRPs – coordinately control the shape, size and number of peroxisomes in a cell
Arf1 and Arf6 are – together with Sar1 – the most comprehensively studied proteins of the ADP-ribosylation factor (ARF) family
Yeast cells deficient in Arf1 or Arf3 exhibit a pronounced increase in peroxisome number on oleate compared to wild-type cells
In view of a continuously increasing number of studies reporting that the ER may provide peroxisomes with lipids and some membrane proteins in the form of a preperoxisomal structure
Additional file 1
Phenotypic analysis of the oleate-grown Δ
Click here for file
Figure 1
Phenotypic analysis of various
Phenotypic analysis of various
Copurification of Arf proteins with rat liver peroxisomes
In order to investigate whether or not any endogenous Arf proteins are associated with mammalian peroxisomes, we probed rat liver subcellular fractions with 1D9, a mouse monoclonal antibody that binds to a linear epitope found in Arf proteins but not in other GTP-binding proteins
Additional file 2
Specificity of the monoclonal anti-Arf6 antibody. (A) Multiple sequence alignment of the rat Arf protein sequences. Amino acids identical in all aligned sequences are shown in red. Amino acid residues identical in five out of six sequences are shown in blue. Note that (i) Arf1 and Arf2 share the highest sequence identity (96% identical at the amino acid level; different amino acids are shaded in green), (ii) the latter protein is absent in humans, (iii) the amino acid sequences of Arf1, Arf3, Arf5 and Arf6 are completely identical in rat and human, and (iv) the amino acids not identical in rat and human Arf4 are highlighted in yellow. (B) Immunoblot analysis of equal amounts of extracts from CHO cells transfected with a monocistronic plasmid coding for Arf4-EGFP or a bicistronic plasmid encoding EGFP-PTS1 and no protein (-) or non-tagged human Arf1, Arf3, Arf5, or Arf6 proteins. The blots were probed with antibodies against EGFP (α-EGFP) or Arf6 (α-Arf6). Note that the expression levels of EGFP-PTS1 allow the indirect quantification of the Arf expression levels. The arrows indicate the migration of the full-length proteins. The arrowheads mark the Arf4-EGFP degradation products. The migration of relevant molecular mass markers (expressed in kDa) is shown at the left. (C) Immunoblot analysis of equal amounts of extracts from bacteria expressing (His)6-GST (H6-GST)-tagged human Arf proteins or a negative control protein (H6-GST-DCOH). The blots were probed with antibodies against (His)6 (α-H6) or Arf6 (α-Arf6). Note that, as – based on a Ponceau S staining – the expression levels of the H6-GST-tagged proteins varied greatly, the blots were cut into three pieces (each containing two conditions yielding similar amounts of recombinant protein) and incubated for different times in alkaline phosphatase-NBT/BCIP staining solution in order to normalize the signal intensities for equal amounts of recombinant protein. The arrows mark full-length proteins, the arrowheads point to degradation products.
Click here for file
Figure 2
Arf6 copurifies with the peroxisomal membrane fractions
Arf6 copurifies with the peroxisomal membrane fractions. (A) Rat liver homogenates were fractionated into a postnuclear (E), a nuclear (N), a heavy mitochondrial (M), a light mitochondrial (L), a microsomal (P), and a cytosolic (S) fraction. A peroxisome-enriched fraction (PO) was obtained by centrifugation of the L-fraction on a Nycodenz step gradient (see Methods). Equal amounts of protein were subjected to SDS-PAGE, transferred to nitrocellulose, and immunoblotted with antibodies raised against the nuclear pore complex protein p62 (Nup62), mitochondrial glutamate dehydrogenase (GDH), lysosomal-associated membrane protein 2 (LAMP2), the ER-resident chaperone immunoglobulin binding protein (BiP/GRP78), the microtubule-binding peripheral Golgi membrane 58 kDa protein (Golgi 58 K), the plasma membrane protein pan-cadherin (Pan-cadherin), the peroxisomal membrane protein Pex13p (Pex13p), peroxisomal biogenesis factor 19 (Pex19p), or a linear epitope found in Arf proteins (1D9). Note that the majority of Golgi 58 K is soluble after fractionation, and that Pex19p is a predominantly cytosolic, partly peroxisomal protein. (B) Six milligrams of total protein from the peroxisomal fraction was processed for floatation centrifugation in an alkaline sucrose gradient (see Methods). The fractions were collected from the bottom, processed for SDS-PAGE, transferred to a nitrocellulose membrane, and stained for total protein with Ponceau S (upper panel). A select set of fractions was immunoblotted with anti-Arf 1D9 or antibodies against Arf6 or peroxisomal matrix (catalase), core (urate oxidase), or membrane proteins (Pex3p, PMP70) (lower panels). The density (in g/ml) of the gradient fractions and the migration of the molecular mass markers (their masses expressed in kDa) are indicated.
Figure 3
Electron microscopic localization of 1D9-immunoreactive proteins in prestained epoxy-embedded preparations of rat liver peroxisomes
Electron microscopic localization of 1D9-immunoreactive proteins in prestained epoxy-embedded preparations of rat liver peroxisomes. Nycodenz-purified rat liver peroxisomes were processed for pre-embedding double immunoelectron microscopy (see Methods). Rabbit anti-PMP70 (α-PMP70) and mouse monoclonal 1D9 antibodies were used as primary antibodies, and 12 nm gold-conjugated anti-rabbit IgG (α-12 nm gold) and 18 nm gold-conjugated anti-mouse IgG (α-18 nm gold) as labels. The primary antibodies were omitted from samples used as negative control (left column). The images were obtained from 75 nm (upper panels) and 300 nm thick (lower panels) sections. The original magnification was 27,800-fold; the scale bar represents 500 nm.
Figure 4
Electron microscopic localization of 1D9- and anti-Arf6-immunoreactive proteins in Nycodenz-purified peroxisomal fractions immobilized on poly-L-lysine-coated grids
Electron microscopic localization of 1D9- and anti-Arf6-immunoreactive proteins in Nycodenz-purified peroxisomal fractions immobilized on poly-L-lysine-coated grids. (A) Prestained organellar fraction (see Methods). Rabbit anti-PMP70 (α-PMP70) and mouse monoclonal 1D9 were used as primary antibodies, and 12 nm gold-conjugated anti-rabbit IgG (α-12 nm gold) and 18 nm gold-conjugated anti-mouse IgG (α-18 nm gold) as labels. (B) Poststained organellar fraction (see Methods). Rabbit anti-PMP70 (α-PMP70) and mouse anti-Arf6 (α-Arf6) were used as primary antibodies, and the same secondary antibodies were used as in panel A. Negative controls were included in parallel in which the primary antibodies were omitted (left panels). The original magnification was 60,000-fold (upper panels), 27,800-fold (lower left panel), or 46,460 fold (lower right panel); the scale bar represents 500 nm.
Figure 5
Organellar distribution of 1D9- and anti-PMP70-immunoreactive proteins in enriched peroxisomal rat liver fractions
Organellar distribution of 1D9- and anti-PMP70-immunoreactive proteins in enriched peroxisomal rat liver fractions. Percoll-, Nycodenz- and Percoll/Nycodenz-purified peroxisomal fractions were processed for pre-embedding double immunoelectron microscopy using anti-Arf 1D9 (18 nm gold grains) and anti-PMP70 (12 nm gold grains) antibodies (see legend to Figure 3). Epon-embedded fractions were quantitatively analyzed for the density of labeling on organellar membranes. The results are expressed as relative specific labeling (R.S.L.) versus percentage of total cell organelles. R.S.L. is hereby defined as the percentage of total gold particles present on a particular organelle divided by the corresponding percentage of total organelles. R.S.L. values greater than one indicate enrichment of the labeling in that specific fraction. The combined total number of cell organelles (x-axis) and gold particles (y-axis) is indicated. Note that the purity of the peroxisomal Percoll, Nycodenz, and Percoll/Nycodenz fractions was 60%, 70%, and 77%, respectively. Abbreviations: PO, peroxisomes (vesicular structures labeled with anti-PMP70 antibodies); MT, mitochondria (double membrane-bound organelles with cristae); O, other vesicles (vesicular structures which could not be unambiguously identified as peroxisomes or mitochondria).
Arf6 is not essential for peroxisome biogenesis in mouse hepatocytes
In order to investigate the potential role of Arf6 in peroxisome biogenesis, we examined the number of peroxisomes, peroxisomal morphology, and the localization of peroxisomal membrane and matrix proteins in
Additional file 3
Arf6 ablation does not alter the localization of catalase in fetal mouse hepatocytes. Primary hepatocytes from mouse embryos (13.5 days) of
Click here for file
Figure 6
Arf6 is not essential for peroxisome biogenesis in fetal mouse hepatocytes from control and clofibrate-treated pregnant mice
Arf6 is not essential for peroxisome biogenesis in fetal mouse hepatocytes from control and clofibrate-treated pregnant mice. (A) Protein (25 μg), present in liver postnuclear supernatants from control (-CF) and clofibrate-treated (+CF) pregnant
Co-overexpression of Arf1 and Arf6 variants impairs peroxisomal protein import in mammalian cells
As a previous study has shown that exogenously added Arf1 can bind to highly purified rat liver peroxisomes
Additional file 4
Effect of co-overexpression of Arf1T31N and Arf6T27N on peroxisomal protein import in Ptk2 cells. Ptk2 cells were transiently transfected with a plasmid coding for Arf1T31N-HA and a bicistronic plasmid encoding EGFP-PTS1 together with Arf6T27N. After 36 hours, the cells were fixed and processed for fluorescence analysis. The top row shows three merged images of the signals observed for Arf1T31N-HA (blue), EGFP-PTS1 (green), and endogenous Pex14p (red). The other rows represent enlarged views of the individual colour components of the areas shown in the insets. Note that the simultaneous expression of Arf6T27N (encoded by the same plasmid as EGFP-PTS1) and Arf1T31N has a strong influence on the localization of newly-synthesized EGFP-PTS1, but only a minor effect on the localization of endogenous Pex14p. Possible explanations for this apparent discrepancy are reviewed in the Results section of the main manuscript. Scale bar: 20 μm.
Click here for file
Additional file 5
Effect of co-overexpression of Arf1T31N and Arf6T27N on the appearance of Pex14p-immunoreactive particles in Ptk2 cells. Ptk2 cells were transiently transfected with a plasmid coding for Arf1T31N-HA and a bicistronic plasmid encoding EGFP-PTS1 together with Arf6T27N. After 36 hours, the cells were fixed and processed for fluorescence analysis. The top row shows three images of the signals observed for endogenous Pex14p (see Additional file
Click here for file
Figure 7
Effect of co-overexpression of Arf1 and Arf6 variants on peroxisomal and mitochondrial protein import in PtK2 cells
Effect of co-overexpression of Arf1 and Arf6 variants on peroxisomal and mitochondrial protein import in PtK2 cells. (A) Ptk2 cells were transiently transfected with plasmids coding for no protein (/), Arf1WT-HA (1), Arf1T31N-HA (1-), or Arf1Q71L-HA (1+) and/or a bicistronic plasmid encoding EGFP-PTS1 together with no other protein (-), non-tagged Arf6WT (6), Arf6T27N (6-), or Arf6Q67L (6+). After 36 hours, the cells were fixed and processed for fluorescence analysis. The subcellular localization of EGFP-PTS1 was determined by its punctate (peroxisomal) or diffuse staining pattern in at least 250 cells, and the results were quantified. (B) Representative images of the subcellular distribution pattern of EGFP-PTS1, HsPMP34-Myc-His, and HsLK2-Myc-His in Ptk2 cells co-overexpressing Arf1T31N and Arf6T27N. Note that the latter protein is encoded by the bicistronic expression vector coding for EGFP-PTS1, and a mislocalization of the reporter proteins is only observed in double-transfected cells. As (i) in mammalian cells the fluorescence intensity of EGFP-PTS1 is significantly higher upon mislocalization to the cytosol
In many instances, the formation of membrane-delimited compartments from pre-existing organelles is regulated by small GTPases of the Rab and Arf family
In this study, we initially investigated whether or not yeast strains deficient in Arf1, Arf2, Arf3, Arl1, Cin4, Vps21, Ypt6, Ypt7, Ypt10, Ypt11, Ypt31, Ypt32, Ypt52 or Ypt53 were capable of growing on oleate as a sole carbon source and/or displayed a peroxisomal protein sorting defect. The results of these experiments demonstrated that all these strains, which embody every viable yeast deletion mutant of the Rab and Sar1/Arf subfamilies of small GTPases, contain functional peroxisomes. Interestingly, the average number of peroxisomes in oleate-grown cells was significantly upregulated in the Δ
We next investigated whether or not endogenous Arf proteins were associated with the membrane of rat liver peroxisomes. In a first series of experiments, we obtained evidence that 1D9, a mouse monoclonal antibody with specificity for mammalian Arf1, Arf2, Arf3, Arf5, Arf6, and – to a lesser extent – Arf4
To study the function of Arf6 in peroxisome biogenesis, we first examined the number of peroxisomes, peroxisomal morphology, and the location of (newly-synthesized) peroxisomal membrane and matrix proteins in (i) Ptk2 cells transiently overexpressing either wild-type Arf6 or a mutant defective in GTP-binding (Arf6T27N) or GTP-hydrolysis (Arf6Q67L) and (ii)
To date, only one group has studied the potential relationship between ADP-ribosylation factors and peroxisome formation in mammalian cells, and shown that exogenously added Arf1 and Arf6 can bind to isolated rat liver peroxisomes
In this study, we provide evidence that endogenous Arf6, the mammalian orthologue of
Male Wistar rats (weighing 200–250 g), Swiss-Webster mice, and New Zealand White rabbits were kept in a constant light-dark cycle on a standard laboratory diet. The rats were fasted 16 hours before sacrifice.
Cloning vectors were obtained from Qiagen (pQE30), Clontech (pEGFP-N1, pIRES2-EGFP) or Stratagene (pCMV-Tag4A, B), and the oligonucleotides synthesized for this study were from Eurogentec. PCR applications were performed routinely using
Yeast strains
The haploid
The polyclonal antiserum against (His)6-HsPex3p(229–364) was raised in New Zealand White rabbits as previously described
Cell culture, transfections, and (immuno)fluorescence microscopy
Primary hepatocytes from mouse embryos (13.5 days) of
Preparation of subcellular fractions and isolation of peroxisomal membranes
Rat liver was homogenized in 0.25 M sucrose, 5 mM MOPS (pH 7.2), 1 mM EDTA (pH 7.2), 0.1% (v/v) ethanol, 1 mM dithiothreitol (DTT), and proteinase inhibitor (PI) mixture (1 μg/ml aprotinin, 0.5 μg/ml leupeptin, 1 μg/ml α2-macroglobulin, and 1 μg/ml chymostatin) and fractionated by differential centrifugation into a nuclear, heavy mitochondrial, light mitochondrial, microsomal, and cytosolic fraction as described before
Immunoelectron microscopy
Percoll, Nycodenz and Percoll/Nycodenz gradient fractions enriched with peroxisomes were fixed in a freshly prepared solution containing 0.25% (v/v) glutaraldehyde-containing, 5 mM MOPS (pH 7.2), 1 mM EDTA (pH 7.2), 1 mM DTT, 0.1% (v/v) ethanol, and PI mixture. In order to prevent osmotic rupture of the organelles, the fixative was supplemented with 0.25 M sucrose (Percoll fractions) or Nycodenz (final density: 1.20 g/ml) (Nycodenz and Percoll/Nycodenz fractions). Fixed samples containing 75 μg or 150 μg of protein were pelleted (11,000 × g, 2 min) and washed by resuspension and pelleting in (i) homogenization buffer (see above), (ii) TBS buffer (0.1 M Tris-HCl (pH 7.4), 9% (w/v) NaCl), and (iii) TBS buffer supplemented with 0.1% (w/v) glycine. Non-specific protein binding sites were blocked for 45 min in TBS buffer supplemented with 1% (w/v) BSA, and the organelle preparations were subsequently incubated with the primary antibodies (mouse 1D9 (1:10 – 1:500) or mouse anti-Arf6 (1:50 – 1:100) and rabbit anti-Pex14p (1:20 – 1:1000) or rabbit anti-PMP70 (1:20 – 1:1000) diluted in TBST (TBS buffer supplemented with 0.05% (v/v) Tween-20)) overnight at 4°C. The next morning, the preparations were washed three times with TBS buffer, incubated with the secondary antibodies (goat anti-rabbit (1:5 – 1:20) and anti-mouse IgGs (1:5 – 1:10) conjugated to 12 nm and 18 nm colloidal gold particles, respectively, diluted in TBST) for two hours at 4°C, and washed three times with TBS buffer (and pelleted for 2 min at decreasing pelleting speeds: 11,000 × g, 5,000 × g, and 2,000 × g). Negative controls were processed in parallel by addition of TBST buffer instead of the primary antibodies. Hereafter, the immuno-treated organelle samples were fixed in TBS buffer supplemented with 0.1 M cacodylate (pH 7.4) and 1% (v/v) glutaraldehyde for 30 min, and subsequently washed with 0.1 M cacodylate (pH 7.4). Afterwards, the samples were post-fixed with aqueous potassium ferricyanide-reduced osmium tetroxide (final concentration: 1% (w/v) OsO4; 150 mg/ml K4 [Fe(CN)6]) for 45 min, shortly rinsed with Milli-Q water, and immobilized on Formvar-coated 400 mesh nickel grids (see below) or embedded in tepid agar-agar (7.5% (w/v) in Milli-Q). The in agar-agar-embedded pellets were carefully cut into small blocks and dehydrated by passage through graded series of ethanol (70% (v/v), 80% (v/v), 90% (v/v), and absolute), transferred to propylene oxide, and embedded in Epoxy resin (Agar 100 Resin Kit, Agar Scientific). The Epon blocks were trimmed and ultrathin sections (75 nm and 300 nm) were put on a 200 mesh copper/rhodium grid. The organelles were contrasted with 2% (w/v) uranyl acetate and Reynold's lead citrate for 2 min and 40 sec, respectively, and rinsed with Milli-Q water. To immobilize immunostained or non-immunostained glutaraldehyde-fixed organelle samples directly on Formvar-coated 400 mesh nickel grids, the grids were first incubated with a poly-L-lysine solution (0.01% (w/v) poly-L-lysine, 0.625% (w/v) boric acid, 0.955% (w/v) sodium tetraborate) for 45 min and subsequently incubated on a drop of the organelle samples for another 45 min. Next, the grids containing immunostained samples were put on a drop of TBS for 10 min, shortly rinsed with the same buffer, and dried. The grids containing non-immunostained organelle samples were washed for 15 min on a drop of TBS and 5 min on a drop of TBS supplemented with 0.1% (w/v) glycine, blocked for 45 min on a drop TBS supplemented with 4% (w/v) BSA, and for one hour incubated with primary and secondary antibodies diluted in TBST supplemented with 0.1% (w/v) BSA. Each antibody incubation was ended by washing the immobilized organelles 12 times for 5 min on a drop of TBS. Negative controls were processed in parallel by addition of TBST buffer instead of the primary antibodies. Finally, the organelle samples were shortly rinsed with TBS, negatively stained by incubating them for 3 min with 0.25% (w/v) uranyl acetate, and dried on a filter paper. All samples were examined with a LEO 906 electron microscope (Zeiss).
Statistical analyses were performed with SAS (Statistical Analysis System) software. ANOVA (Analysis of Variance) was used to determine the differences among independent groups of numerical values, and multiple comparisons with Tukey-Kramer adjustment were used to determine which groups were significantly different from the wild-type group. The significance level was chosen to be 0.05.
Authors' contributions
EAA carried out the phenotypic analysis of the yeast strains, performed the immunofluorescence microscopic experiments, participated in the preparation and analysis of the subcellular fractions and the electron microscopy samples, and helped to draft the manuscript. CB prepared the expression constructs and performed the yeast transformations. EB supervised the electron microscopy experiments. TH and YK provided the primary hepatocytes from mouse embryos of
We thank Dr. S.R. Terlecky (Wayne State University School of Medicine, Detroit, Michigan) for critically reading the manuscript, Ms. M. Brams (LIPIT, K.U.Leuven, Belgium) and Ms. E. Vanderheyden (Department of Biology, K.U.Leuven) for their excellent technical support, Mr. G. Magdowski, Mr. G. Kripp, and Ms. B. Pfeiffer (all three of the Institute für Anatomie und Zellbiologie II, Justus-Liebig Universität, Germany) for their professional help in the electron microscopic work, and Mr. P.J. Thilakarathne (Leuven Biostatistics and Statistical Bioinformatics Centre, K.U.Leuven, Belgium) for his guidance and suggestions on statistical analyses.
This work was supported by grants from the Flemish Government (Geconcerteerde Onderzoeksacties GOA2004/08), the Fonds voor Wetenschappelijk Onderzoek – Vlaanderen (Onderzoeksproject G.0754.09), the FP6 European Union Project 'Peroxisome' (LSHG-CT-2004-512018), as well as the German Research Foundation (DFG KFO 181/1, P3).
Biochemistry of mammalian peroxisomes revisited
Plant peroxisomes
Peroxisomes and oxidative stress
Yeast and filamentous fungi as model organisms in microbody research
Involvement of the endoplasmic reticulum in peroxisome formation
Peroxisomes start their life in the endoplasmic reticulum
The origin and maintenance of mammalian peroxisomes involves a
The ER-peroxisome connection in plants: development of the "ER semi-autonomous peroxisome maturation and replication" model for plant peroxisome biogenesis
Biogenesis of peroxisomes
Yeast peroxisomes multiply by growth and division
Peroxisome proliferation in
The peroxisome: still a mysterious organelle
Dynamin-related proteins and Pex11 proteins in peroxisome division and proliferation
Fis1, DLP1, and Pex11p coordinately regulate peroxisome morphogenesis
The novel tail-anchored membrane protein Mff controls mitochondrial and peroxisomal fission in mammalian cells
Peroxisome biogenesis: where Arf and coatomer might be involved
Peroxisome biogenesis: involvement of ARF and coatomer
ARF- and coatomer-mediated peroxisomal vesiculation
Binding and functions of ADP-ribosylation factor on mammalian and yeast peroxisomes
Peroxisome biogenesis: the peroxisomal endomembrane system and the role of the ER
Localization of the tomato bushy stunt virus replication protein p33 reveals a peroxisome-to-endoplasmic reticulum sorting pathway
The small G proteins of the Arf family and their regulators
ARF proteins: roles in membrane traffic and beyond
Arf6 and microtubules in adhesion-dependent trafficking of lipid rafts
Multiple activities for Arf1 at the Golgi complex
The GGA proteins: adaptors on the move
Import of peroxisomal membrane proteins: the interplay of Pex3p- and Pex19p-mediated interactions
Small GTP-binding proteins
Isolation of peroxisome-deficient mutants of
Intracellular distribution of Arf proteins in mammalian cells. Arf6 is uniquely localized to the plasma membrane
Crucial role of the small GTPase ARF6 in hepatic cord formation during liver development
Three-dimensional ultrastructural analysis of peroxisomes in HepG2 cells. Absence of peroxisomal reticulum but evidence of close spatial association with the endoplasmic reticulum
Characterization of a glucose-repressible ADP-ribosylation factor 3 (ARF3) from
Isoform-selective effects of the depletion of ADP-ribosylation factors 1–5 on membrane traffic
Dominant inhibitory mutants of ARF1 block endoplasmic reticulum to Golgi transport and trigger disassembly of the Golgi apparatus
A role for POR1, a Rac1-interacting protein, in ARF6-mediated cytoskeletal rearrangements
A regulatory role for ARF6 in receptor-mediated endocytosis
Peroxisome dynamics in cultured mammalian cells
Arf GAPs and membrane traffic
Coats, tethers, Rabs, and SNAREs work together to mediate the intracellular destination of a transport vesicle
Quantitative mass spectrometry reveals a role for the GTPase Rho1p in actin organization on the peroxisome membrane
An isoform of
Identification of peroxisomal membrane proteins of
Approaching complete peroxisome characterization by gas-phase fractionation
Proteomic analysis of rat liver peroxisome: presence of peroxisome-specific isozyme of Lon protease
Proteomic characterization of the effects of clofibrate on protein expression in rat liver
Quantitative proteomic comparison of mouse peroxisomes from liver and kidney
Rat liver peroxisomes after fibrate treatment. A survey using quantitative mass spectrometry
Proteomics characterization of mouse kidney peroxisomes by tandem mass spectrometry and protein correlation profiling
Cargo-selected transport from the mitochondria to peroxisomes is mediated by vesicular carriers
Overexpression of wild-type and mutant ARF1 and ARF6: distinct perturbations of nonoverlapping membrane compartments
Subcellular distribution and differential expression of endogenous ADP-ribosylation factor 6 in mammalian cells
Localization and activation of the ARF6 GTPase during cleavage furrow ingression and cytokinesis
A quantitative analysis of fine structure and drug metabolism in livers of clofibrate-treated young adult and retired breeder rats
Further characterization of mammalian ceramide kinase: substrate delivery and (stereo)specificity, tissue distribution, and subcellular localization studies
Role of the Arf6 GDP/GTP cycle and Arf6 GTPase-activating proteins in actin remodeling and intracellular transport
Active Arf6 recruits ARNO/cytohesin GEFs to the PM by binding their PH domains
Maternal clofibrate administration amplifies fetal peroxisomes
The I.M.A.G.E. Consortium: an integrated molecular analysis of genomes and their expression
DEF-1/ASAP1 is a GTPase-activating protein (GAP) for ARF1 that enhances cell motility through a GAP-dependent mechanism
Peroxisome biogenesis: characterization of the import process of peroxisomal integral membrane proteins
Identification of a novel
Human Pex19p binds peroxisomal integral membrane proteins at regions distinct from their sorting sequences
Analysis of mammalian peroxin interactions using a non-transcription-based bacterial two-hybrid assay
Overexpression of Pex15p, a phosphorylated peroxisomal integral membrane protein required for peroxisome assembly in
Identification of PEX5p-related novel peroxisome-targeting signal 1 (PTS1)-binding proteins in mammals
Identification, purification and characterization of an acetoacetyl-CoA thiolase from rat liver peroxisomes
Identification of a human PTS1 receptor docking protein directly required for peroxisomal protein import
Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product
Stable expression of fluorescently tagged proteins for studies of mitosis in mammalian cells
Identification of peroxisomal proteins by using M13 phage protein VI phage display: molecular evidence that mammalian peroxisomes contain a 2,4-dienoyl-CoA reductase
Presence of small GTP-binding proteins in the peroxisomal membrane
Permeability of the peroxisomal membrane to cofactors of beta-oxidation. Evidence for the presence of a pore-forming protein
Mitochondrial and peroxisomal beta oxidation of the branched chain fatty acid 2-methylpalmitate in rat liver
Alkaline density gradient floatation of membranes: polypeptide composition of the mammalian peroxisomal membrane
Properties of the ubiquitin-Pex5p thiol ester conjugate


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Hello Athens Friends and Family!
Thanks again for coming to our fashion show! We had a great nite! We appreciate you checking out our site:) Take $10 off any piece in this section by using the code LUSHLOVE10 when you check out:) Have a fabulous day! - Troy and Stephano


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Awesome monitor!
This ASUS has beautiful color and is bigger in every way than our 19" Dell. The HD is super and colors are true and bright. You won't be disappointed with this.
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This ASUS has beautiful color and is bigger in every way than our 19" Dell. The HD is super and colors are true and bright. You won't be disappointed with this.
-A customer
Would have been a great deal if it worked out of the box!! DOA!! Blue screen of death!! Looks nice, thin, light. Contacted ASUS tech support and was told to send it back. Buy.com customer service was expedient in issuing an RMA, but unfortunately all I can get is a credit as they have no more (weeks from now as I have to ship it all the way across the country - one of the negative's of online buying). I'm curious why I still see it being offered on their site if it's out of stock as I was told??? Made in China like everything else!
This ASUS has beautiful color and is bigger in every way than our 19" Dell. The HD is super and colors are true and bright. You won't be disappointed with this.
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I am very impressed with the picture quality and low energy consumption LED technology at this price. The screen looks amazingly superior in finishing as well. The touch buttons are great. On top of that, Buy.com customer service is A+++. The week after I bought this monitor, the price went down by $15. When I contacted the customer service asking if they had price guarantee, $15 was credited to my account the very next day. Thank you very much!
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Visual Brilliance
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Cypress Creek Elementary is the only known school at Cypress Creek. Mr. Doyle and the Remedial Class Teacher work here.
Bart and Lisa went to this school when Homer got a job at Globex Corporation. Bart was put in a remedial class at this school when he had trouble reading cursive.
- Cool kid
- Cypress Creek Milhouse
- Dot
- Gordy
- Warren
- Melvin
- Gary
- Bart Simpson (Former)
- Lisa Simpson (former)
The sign reads "http//www.studynet.edu." This website is nonexistent.


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March 14 (3-14), is the day when math enthusiasts all around the world celebrate Pi Day. Almost everybody knows (but we will mention it anyway) that Pi (3.141592…) is the value with which the ratio of the circumference of a circle to its diameter is calculated. To people who don't like and those who don't really care about mathematics, this might just be another boring number.
But for math devotees around the world, this number is considered to be 'magical' and 'beautiful'. Ancient Egyptian and Greek scientists and mathematicians spent their lives trying to approximate its value. Hundreds of years later, math enthusiasts are still after it. Pi day, is therefore a day dedicated to the 'magic' and 'beauty' of this number. It is also the day when all mathematics nerds get a chance to gather and celebrate while the rest of the less intelligent beings live on with their lives without even knowing it is Pi Day.
Twitter is abuzz with people celebrating, commenting, (even) lamenting, talking, discussing about Pi Day. There were some tweets that were exceptionally brilliant. Let's have a look at them:
Happy #PiDay day from our team to yours! 3.14 #agilityloyalty pic.twitter.com/M7AHjTBfwZ— Agility Loyalty (@AgilityLoyalty) March 14, 2016
#PiDay call for spanakopita! Here's my mom's recipe for the best spanakopita around! https://t.co/FTilgsnB0H pic.twitter.com/WVwpC5geHm— Tig|APinchofLemon (@antigonisander) March 14, 2016
Happy #PiDay! Read-up before you eat-up. My vice is a slice, @SeattleRefined. https://t.co/tk7al5eMVx pic.twitter.com/hsLi8Et4Zt— Scott Carty (@ScottCarty) March 14, 2016
THERE ARE 3.14159265 REASONS TO JOIN THE BURNING LEGION!#PiDay pic.twitter.com/WkshXwoAPf— World of Warcraft (@Warcraft) March 14, 2016
Happy #PiDay! Our pie of #SDO wavelengths shows some of the ways we observe the sun. More: https://t.co/q352BwsgJk pic.twitter.com/JgDNS7cNgW— NASASunEarth (@NASASunEarth) March 14, 2016
Happy Pi Day! Take our "Pi in the Sky" challenge & solve some of the problems we do: https://t.co/Y8jeDjhMFZ #PiDay pic.twitter.com/Q6i05mPdwI— NASA (@NASA) March 14, 2016
Happy Birthday Albert Einstein 💙 #PiDay pic.twitter.com/Tr9iQsAPyU— Efuru (@JheneAiko) March 14, 2016
Happy #NationalPiDay! π #PiDay pic.twitter.com/XuexdLeZXt— Good Morning America (@GMA) March 14, 2016
Happy #PiDay! How many digits can you recite? https://t.co/SU5D0AYI38 pic.twitter.com/2qzvksRy1B— CNN International (@cnni) March 14, 2016
It's Pi Day! No better way to celebrate your knowledge of mathematics than by enjoying a slice of pie heaven. Eat smartly, my friends.— Randa Wells (@notesfromranda) March 14, 2013
I'm just really excited for Pi day in two years because the date will 3/14/15.— Maddie Crichton (@maddz99) March 14, 2013
Sorry, everyone. I can't hang out today. I'm too busy studying pi. #PiDay— Garth Algar (@v0lvagia) March 14, 2013
Lets start Pi Day off with a quote from Mr Donovan "Electrons are kind of like Communism... All they want to do is share!"— MatthewFrank Maggio (@Maggio6_95) March 14, 2013
He has a point:
Happy pi day everyone. Celebrate at 1:59 if you want to be super nerdy. #fb— Jason Mills (@goteemills) March 14, 2013
Acknowledgement of Pi Day so that I can feel intelligent.— shrek is stupid (@LizzyofDanville) March 14, 2013
Today is pi day! At exactly 3:14:15, I will be enjoying myself a piece if cherry pie!— Laura B (@themommybee) March 14, 2013
Rebecca Black would surely be impressed with this tweet:
It's pi day, pi day Gotta get down on pi day Everybody's calculating the Area of a circle 3.14159! 3.14159! Math math math math Pi is an...— jBones (@jbones3000) March 14, 2013
In honor of Pi Day I wish we could all only work 3.14 hours today #IWish #HappyPiDay— Its*me*Angela*G (@Angelaaa_xoXO) March 14, 2013
It's 3/14, so Happy Pi Day, tweeples! Have a wedge of your favorite pie to and think mathematical thoughts— Monica Schnitger (@monica_schnitge) March 14, 2013
There are more. But try to get your own tweet out and make it creative. Happy pi day to all!


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Here are a few more Kroger deals that you can grab when you do your shopping. You can get Chex Mix, Bugles or Gardetto's for only $.50 each. There are also nice deals on Heluva Good Dip, Rubbermaid LunchBlox Kits and True Lemon or Lime Sticks!
At Kroger:
BUY ONE HELUVA GOOD DIP 12 oz – on sale $1.50
use one $.75/1 Heluva Good Dip SS 5/17
Net Price: $.75
BUY TWO RUBBERMAID LUNCHBLOX KITS – on sale BOGO $12.99
use two $2/1 Rubbermaid Lunch Kit: LunchBlox or LunchBlox Kids printable
Net Price: $8.99 ($4.50 each!)
BUY TWO CHEX MIX, BUGLES OR GARDETTO'S 7.5 – 8.75 oz – on sale $1
Get $.50/2 Chex Mix, Chex Mix Muddy Buddies, Chex Mix Popped, Chex Mix Xtremee, Chex Chips, Bugles Corn Snacks or Gardetto's Snack Mix Savingstar Offer
use one $.50/2 Chex Mix, Chex Mix Muddy Buddies, Chex Mix Popped, Chex Mix Extreme, Chex Chips, Bugles Corn Snacks or Gardetto's Snack Mix printable (preclipped)
Price at register: $1.50 but recieve $.50 Savingstar deposit
Net Price: $1 ($.50 each!)
BUY ONE TRUE LEMON AND LIME STICKS 7 & 10ct – on sale $2.50
use one $.70/1 True Citrus Product printable (preclipped)
Net Price: $1.80
Thanks KCL and Kroger KrazyExtreme Couponing Tip: You can usually get two prints of most internet coupons. To find them in the easiest possible way, use our preclipped links that take you right to the coupon. Then come back and click the same link to get your 2nd print. This will save you the time spent searching for the coupon.
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