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1 Copyright JCPDS - International Centre for Diffraction Data 2005, Advances in X-ray Analysis, Volume ELEMENTAL IMAGING FOR PHARMACEUTICAL TABLET FORMULATION ANALYSIS BY MICRO X-RAY FLUORESCENCE Thomasin C. Miller a, George J. Havrilla b a X-ray Optical Systems INC., East Greenbush, NY b Chemistry Division, Los Alamos National Laboratory, Los Alamos, NM ABSTRACT The analysis of the distribution of pharmaceutical materials in tablet formulations, such as drugs and matrix elements, is critical to product performance and is used in such areas as quality control, impurity testing, and process monitoring. Recently imaging techniques, such as Raman, near-ir, and fluorescence imaging, have become popular for visualization of pharmaceutical formulations, allowing for spatial and chemical composition information to be obtained simultaneously. These methods have been primarily focused on molecular imaging, or spatial analysis of the molecular characteristics of the tablet formulation. However, elemental species are also an important part of pharmaceuticals. Micro X-ray Fluorescence (MXRF) elemental imaging offers complementary information to molecular imaging techniques. In this study, MXRF was used for the elemental imaging of various commercial pharmaceutical drug and vitamin supplements. Specifically, elemental composition and heterogeneity were monitored for each different tablet. INTRODUCTION The distribution, particle size, and morphology of pharmaceutical materials within a tablet dosage form, such as drugs, lubricants, and excipient components, affect a number of properties of the tablet. These include physical attributes such as tablet hardness, robustness, and adhesion to the tablet punch, as well as more chemical characteristics such as tablet lifetime, component bioavailability and bodily uptake [1]. Many different types of analysis techniques have been used to study the characteristics of the components in pharmaceutical powders and oral dosage forms. For example infrared (IR) spectroscopy and nuclear magnetic resonance (NMR) spectroscopy have been used to study pharmaceuticals at the molecular level [2]. Particle morphology and size distribution can be characterized by techniques such as scanning electron microscopy (SEM) and X-ray diffraction (XRD) [2]. Atomic force microscopy (AFM) has been used to study the effects of mechanical processing on surface stability of pharmaceutical powders [3]. Total reflection X-ray fluorescence (TXRF) has been used to study trace elements in drugs [4]. One of the major drawbacks of many of the techniques listed above, such as IR, SEM, XRD, and AFM, is that they only allow for either single point analyses or characterization of only a small area of a tablet. Techniques such as TXRF and NMR require that the pharmaceutical solid be dissolved prior to analysis, altering the original state of the material. Imaging techniques are becoming popular as new methods for analyzing solid dosage forms. These techniques are often non-destructive and allow for the acquisition of component distribution information over a relatively large area of a tablet. They also require minimal sample preparation and manipulation, leaving the sample intact and in its original state during
2 This document was presented at the Denver X-ray Conference (DXC) on Applications of X-ray Analysis. Sponsored by the International Centre for Diffraction Data (ICDD). This document is provided by ICDD in cooperation with the authors and presenters of the DXC for the express purpose of educating the scientific community. All copyrights for the document are retained by ICDD. Usage is restricted for the purposes of education and scientific research. DXC Website ICDD Website -
3 Copyright JCPDS - International Centre for Diffraction Data 2005, Advances in X-ray Analysis, Volume analysis. Specifically, molecular imaging techniques have been implemented for tablet and powder characterization. Fourier transform near infrared (FT-NIR) methods have been used to study the distribution of different organic ingredients in tablets with a spatial resolution of ~ µm [5]. Attenuated total reflection infrared imaging has been used to look at the distribution of molecular species with a spatial resolution of ~ 4-15µm [6, 7]. Molecular Raman imaging, which is complementary to IR imaging, as also been successfully used for pharmaceutical tablet component characterization [5, 8]. Molecular imaging techniques such as IR and Raman are excellent for studying organic components and molecular species which have strong IR and Raman signals. However, pharmaceutical dosage forms also contain many inorganic constituents that are often very important to tablet function and may not be easily detected by molecular techniques. For example vitamin tablets, such as Vitamin B-12 or iron supplements, contain metals that are integral to their function. Inorganic species such as calcium phosphate and magnesium stearate are used as tablet binders and lubricants respectively. Similarly, monitoring of potential drug contamination by inorganic impurities, e.g. halogens, arsenic, and the heavy metals, is also important to pharmaceutical quality control. One alternative is to use elemental imaging for study of tablet inorganic components which would complement the information gathered by molecular imaging techniques. Laser induced breakdown spectroscopy (LIBS) has been used for elemental imaging of solid dosage forms[9]. However, the technique is destructive, as the laser ablates the surface of the sample during each analysis. In this study, a non destructive elemental imaging technique using Micro X-ray Fluorescence (MXRF) was used to study the elemental distributions of inorganic components in pharmaceutical oral dosage forms. EXPERIMENTAL MXRF imaging was performed in vacuum using an EDAX Eagle II XLP system equipped with a Rh target excitation source and a SiLi detector (EDAX, Mahwah, NJ). The X-ray source was equipped with a polycapillary focusing optic having a 60 µm nominal X-ray spot diameter (Xray Optical Systems, Albany, NY). Figure 1 is a diagram of the MXRF experimental setup. Figure 1. Diagram of MXRF instrumental setup. For each tablet, images were acquired with a pixel matrix of 128x100 and a 200 ms dwell time per pixel. Table 1 lists the element emission lines and energies that were monitored in this study. The commercially available pharmaceutical tablets used in this study were purchased at random at a local grocery store. A list of the different types of tablets used in this study as well a list of their major ingredients that could possibly be detected by MXRF is listed in Table 2. The tablets were prepared for imaging by slicing them in half with a stainless steel razor blade so that a flat, even surface was exposed to the instrument for analysis. Care must be taken that the razor blade is new (not rusty) and clean, and that it is cleaned between preparation of different specimens to avoid sample contamination.
4 Copyright JCPDS - International Centre for Diffraction Data 2005, Advances in X-ray Analysis, Volume Table 1. Element emission lines and energies monitored in this study. Element Emission Line Emission Line Energy (kev) Na K-L 2,3 (Ka) Mg K-L 2,3 (Ka) Si K-L 2,3 (Ka) P K-L 2,3 (Ka) S K-L 2,3 (Ka) Bi M 5 -N 6,7 (Ka) Rh L 3 -M 4,5 (La) Ca K-L 2,3 (Ka) Fe K-L 2,3 (Ka) C0 K-L 2,3 (Ka) Zn K-L 2,3 (Ka) Bi L 3 -M 4,5 (La) Table 2. Ingredients of pharmaceutical tablets investigated in this study that may be detected by MXRF. Tablet Ingredients Stomach Relief Bismuth subsalicylate, calcium carbonate, magnesium stearate, mannitol, sodium saccharin, sodium Iron Supplement Calcium carbonate, ferrous sulfate, croscarmellose sodium, silicon dioxide, magnesium stearate, titanium dioxidesodium carboxymethylcellulose, sodium citrate Vitamin B-12 Dicalcium phosphate, magnesium stearate, cyanocobalamin Multivitamin Calcium carbonate, magnesium oxide, ferrous fumarate, croscarmellose sodium, zinc oxide, magnesium stearate, titanium dioxide, d-calcium pantothenate, calcium silicate, silicon dioxide, cyanocobalamin MXRF elemental phase imaging was achieved with a multivariate statistical automated analysis program developed by Sandia National Laboratory (Albuquerque, NM). The program was originally developed for spectral imaging with scanning electron microscopy (SEM) and was adapted for use with MXRF. The program is described in detail in Kotula et al. [10]. ELEMENTAL MAPPING OF PHARMACEUTICAL TABLETS Elemental X-ray mapping is a process by which a window about a range of X-ray energies is integrated and displayed as an image. From these mapped images, qualitative elemental distributions from a chosen area of a sample can be visualized and compared. Micro X-ray Fluorescence (MXRF) elemental mapping offers complementary information to molecular mapping techniques. MXRF can detect elemental composition for a given sample by measuring its characteristic X-ray emission wavelengths or energies. Mesoscale ( > 10 µm 2 ) analysis is achieved through the use of a polycapillary focusing optic in conjunction with a Rh X-ray tube source, which focuses the source X-rays into a nominal spot size of ~60 µm in diameter. MXRF allows for simultaneous elemental analysis with both quantitative and qualitative analysis of elements Z = Na. It is a nondestructive technique and requires minimal sample preparation. In this study, MXRF elemental mapping was used to study the distribution of inorganic components in pharmaceutical tablet formulations. The ingredients that could possibly be
5 Copyright JCPDS - International Centre for Diffraction Data 2005, Advances in X-ray Analysis, Volume 48. detected by MXRF contained in each of the pharmaceutical tablets analyzed in the study are listed in Table 2. Figure 2 shows the MXRF elemental maps for a stomach relief tablet. Bismuth and Ca could be detected in the tablet by MXRF. Both sodium and magnesium were present below the detection limit of the instrument and could not be mapped. The elemental maps show that the Bi and Ca are distributed very evenly throughout the tablet. Figure 2. MXRF elemental maps of a 3.9 mm x 3.7 mm area of a stomach relief tablet. Source setting: 30 kv, ma. Figure 3 shows the MXRF elemental maps for an iron supplement tablet. The elements that could be detected above background in the tablet include Si, S, Ca, and Fe. Again the distributions of the different elemental components can be observed in the MXRF maps and overlays. There is a strong correlation between the Fe and S signals due to the presence of Fe in the tablet as ferrous sulfate. The areas of high Fe and S intensity are complementary to those where Ca is present, indicating that the Ca is a separate component. Si is also present, with a signature that does not correlate with Fe, S, or Ca. Figure 3. MXRF elemental maps of a 3.9mm x 3.4mm area of an iron supplement tablet. Source setting: 35 kv, 0.1 ma. Two different brands of vitamin B-12 supplements, each containing the same amount of Co containing cyanocobalamin (500 mcg), were chosen for MXRF imaging to show how MXRF can detect differences in the constituent makeup between different tablets of the same character. Figure 4 shows the MXRF elemental images for the two different vitamin B-12 tablets. The major elemental components are Ca and P from the dicalcium phosphate binder and Co from the 277
6 Copyright JCPDS - International Centre for Diffraction Data 2005, Advances in X-ray Analysis, Volume 48. cyanocobalamin (also known as Vitamin B-12). Notice that for both tablets, the Ca and P signals seem to be correlated and that they are both complementary to areas showing significant Co intensity. Interestingly, the distribution of the three elemental components is very different between the two tablets. In tablet (a), the Ca and P are present as small particulates in the sample while Co is distributed evenly throughout the tablet. For tablet (b), the opposite is the case. Calcium and phosphorus are present throughout the tablet with Co filling the smaller gaps in between. So even though both tablets have approximately the same chemical make-up, the component distributions are very different. Figure 4. Comparison of MXRF P, Ca, and Co elemental maps for two different brands, (a) and (b), of Vitamin B-12 supplement tablets. The area for each image is ~3mm x 2.5mm. Source setting: 35 kv, 0.15 ma. Figure 5 shows the MXRF maps of the elemental species present in a multivitamin tablet. Notice that the tablet contains many different species that are detectable by MXRF. There seems to be some correlation between the Zn and Si species. Calcium is present in the highest abundance in the tablet and is present throughout. There are many more components in the multivitamin tablet than in the simpler tablets discussed above. Correlations by eye are much harder to make, and an elemental overlay was not shown for this example because the resulting image was too complicated to aid interpretation. Figure 5. MXRF elemental maps of the major elemental components of a multivitamin tablet. The image area is approximately 3.4 mm x 3.4 mm. Source setting: 35 kv, 0.1 ma. As shown in the examples above, MXRF offers powerful capabilities in elemental mapping. Areas, as small as several hundred micrometers and as large as tens of centimeters, can be 278
7 Copyright JCPDS - International Centre for Diffraction Data 2005, Advances in X-ray Analysis, Volume scanned to produce elemental images. These qualitative elemental images can clearly identify areas of heterogeneity, give relative distributions of the elements, and highlight areas of interest for higher resolution probes. However, the major drawback of all MXRF based mapping is the resulting elemental images can only be correlated to other elements visually or thought map overlays. In most cases this is simply achieved by visually inspecting the different elemental images and trying to correlate the elemental maps by eye. Generally this is not difficult when the composition consists of only a few elements. However, when the elemental composition increases to five or more elements, visual correlation of the individual elemental images can be difficult at best. The major concern is a critical elemental correlation can be overlooked if an element was not identified in the initial scan, or the elemental correlation is subtle or insufficient for distinct registration of the separate elemental images, effectively concealing any correlations. ELEMENTAL SPECTRAL IMAGING OF SELECT TABLETS As shown above, X-ray mapping involves the integration of X-ray energies in specific regions of interest (ROIs) over a given area of sample which are displayed as images. From these images one can visualize qualitative elemental distributions from an area of the sample. However, the mapping results are generally not quantitative without the use of standards. Mapping generally relies on the foreknowledge of elements in the sample so that specific ROIs can be designated for integration. Often with samples containing many different elemental components, elemental correlations are difficult. For example, Figure 4 shows a simple overlay of the P, Ca, and Co components in the Vitamin B-12 tablets. It can be seen that there is some correlation between the Ca and P components and that they are both complementary to the Co component. However, making elemental correlations with a more complex sample, like the multivitamin shown in Figure 5, is much more difficult. There seems to be some correlation of the Zn and Si components. Ca seems to be present throughout the tablet and complementary to all of the other elements. However, these conjectures are not definitive and elemental map overlays would be too convoluted to be of any interpretive help in this case. An X-ray spectral image is a two-dimensional array of pixels taken from an area of sample that contains a complete X-ray spectrum from each point. X-ray spectral imaging overcomes the disadvantages of X-ray mapping because a complete spectrum is collected from each pixel; no spectral information (elements) is left out or lost. However, spectral imaging often involves the time-consuming collection of very large data sets, much of the information contained in these data sets is redundant, and it is usually difficult to extract chemically relevant data from it. To overcome the problems of conventional X-ray spectral imaging, a new multivariate statistical analysis technique was developed by Sandia National Laboratory (SNL) to automatically analyze X-ray spectral data sets from electron excitation on an SEM [10] and was adapted for application to X-ray tube excited spectra. The method returns physically accurate component spectra and images with only a few minutes of data processing time. The result is not only elemental images, but also elemental phases or chemical phases based on elemental composition. This then removes the subjective nature of the visual correlation and enables the visualization of both major and subtle elemental correlations. No assumptions about the absence or presence of any constituent are made prior to analysis. The method has the ability to handle extremely noisy data and significant spectral overlaps, so data acquisition times can be drastically reduced to obtain
8 Copyright JCPDS - International Centre for Diffraction Data 2005, Advances in X-ray Analysis, Volume experimentally relevant data. Image processing times are very short (minutes) and quantitative agreement is maintained between raw and reconstructed data. Figure 6 shows the 4 principal components as well as the component overlay returned by SNL s automated image analysis program for a Vitamin B-12 tablet. Notice that the image area for the automated analysis is the same as that shown for the X-ray elemental mapping for tablet (a) in Figure 4. The initial X-ray mapping experiments took approximately 1 h with a 200 ms dwell time per pixel. Conversely, data acquisitions for automated analysis only took 18 min with 50 ms per pixel with no distinct loss in resolution. The automated analysis of the spectral data took on the order of 2 min to complete, for a total acquisition and analysis time of 20 min; a factor of three times less than for X-ray mapping. For the Vitamin B-12 tablet analysis, phase 1 is primarily made up of the Bremsstrahlung background. Phase 2 consists of both Ca and P, and is indicative of the calcium phosphate binder present in the tablet. Phase 3 is a separate Ca phase (possibly due to Ca present in lactose or corn starch). Notice that this component is not visually observable in the elemental maps present in Figure 4. Phase 4 is Rh scatter from the Rh X-ray source off of the sample surface. Also notice that the overlay of 4 automated analysis components is much easier to visualize and interpret than those shown for elemental mapping. Figure 6. Elemental phase images of Vitamin B-12 tablet 1 (same area as shown in Figure 4). The yellow circle identifies the Co peak from cyanocobalamin. Interestingly, a separate phase for the Co from the main cyanocobalamin component in Vitamin B-12 is absent from the principal components returned by the spectral imaging program. If one looks carefully, one can see that the small Co X-ray peak is present in Phase 1 as part of the Bremsstrahlung background (peak is circled in yellow). This is because the small Co signal could not be separated from the very large Bremsstrahlung background. A background
9 Copyright JCPDS - International Centre for Diffraction Data 2005, Advances in X-ray Analysis, Volume subtraction routine is currently being integrated into the program to allow for trace components to be more easily identified. Figure 7 shows the 5 principal components as well as the component overlay for the more complex multivitamin matrix. Phase 1 is primarily made up of calcium. The major component of phase 2 is Fe. Phases 3 and 4 have Zn and Mg in highest abundance respectively. Phase 3 also shows traces of S and Si, while phase 4 contains traces of Ca, Ti, Fe, and Co. Phase 5 is composed of both Rh scatter from the X-ray source as well as Ca. The distribution of these different phases is very easy to see in the component overlay. Figure 7. Elemental phase images of a multivitamin tablet (same area as shown in Figure 5). In short, multivariate statistical analysis allows for much easier viewing and interpretation of elemental correlations within a sample. Furthermore, components are often identified, like the extra Ca component in the Vitamin B-12 tablet, which would easily be missed otherwise. CONCLUSIONS In this study, MXRF was used as a new tool for elemental imaging of pharmaceutical oral dosage forms. The distribution of inorganic species within a tablet can easily be visualized and correlations can be made between different components. Multivariate statistical analysis techniques can enhance elemental imaging capabilities by allowing for the extraction of elemental phases from raw spectral imaging data, eliminating bias errors and elemental omissions from human visual interpretation and comparison of elemental images. However, not all components in a tablet dosage form are inorganic in nature. Pharmaceutical materials are often made from a variety of both organic and inorganic components. Therefore, both elemental as well as molecular imaging techniques are needed to properly make a full characterization of
10 Copyright JCPDS - International Centre for Diffraction Data 2005, Advances in X-ray Analysis, Volume the distribution of all tablet constituents. The next logical step of this work is to implement integrated chemical imaging, where both elemental and molecular imaging techniques are used to characterize pharmaceutical materials. To achieve successful chemical imaging, tablets must be prepared so that they can be imaged by a variety of techniques in a routine manner. Specifically, very precise methods of sample preparation will be needed so that the exposed tablet areas are very smooth and flat for optimal analysis by different imaging methods. Also, stage registration techniques will have to be implemented so that the exact same area on a given sample can be imaged by many different techniques in different instruments so that direct comparisons can be made between inorganic and organic component distributions. These efforts are currently being investigated. ACKNOWLEDGEMENTS TCM was supported by the Director of Central Intelligence (DCI) Postdoctoral Research Fellowship Program. The authors would also like to thank Paul Kotula and Michael Keenan from Sandia National Laboratory for adapting the AXSIA program for MXRF imaging. REFERENCES [1] J. D. Higgins III, and W. L. Rocco, Pharma Preformulation, Today's Chemist at Work 12 (2003) [2] H. G. Brittain, S. J. Bogdanowich, D. E. Bugay, J. DeVincentis, G. Lewen, and A. W. Newman, Physical Characterization of Pharmaceutical Solids, Pharmaceutical Research 8 (1991) [3] P. Begat, P. M. Young, S. Edge, S. Kaerger, and R. Price, The Effect of MEchanical Processing on Surface Stability of Pharmaceutical Powders: Visualization by Atomic Force Microscopy, J. Pharm. Sci. 92 (2003) [4] M. Wagner, P. Rostam-Khani, A. Wittershagen, C. Rittmeyer, B. O. Kolbesen, and H. Hoffman, Trace element determination in drugs by total-reflection X-ray fluorescence spectrometry, Spectrochim. Acta B 52 (1997) [5] F. C. Clarke, M. J. Jamieson, D. A. Clark, S. V. Hammond, R. D. Jee, and A. C. Moffat, Chemical Image Fusion. The Synergy of FT-NIR and Raman Mapping Microscopy to Enable a More Complete Visualization of Pharmaceutical Formulations, Anal. Chem. 73 (2001) [6] B. D. Butkus, Diamond improves optical analysis of pharmaceutical tablets, Biophotonics International July 2003 (2003) [7] K. L. A. Chan, S. V. Hammond, and S. G. Kazarian, Applications of Attenuated Total Reflection Infrared Spectroscopic Imaging to Pharmaceutical Formulations, Anal. Chem. 75 (2003) [8] M. D. Schaeberle, H. R. Morris, J. F. Turner II, and P. J. Treado, Raman Chemical Imaging Spectroscopy, Anal. Chem. (1999) 175A-181A. [9] Y. Mouget, P. Gosselin, M. Tourigny, and S. R. Bechard, Three-dimensional analyses of tablet content and film coating uniformity by laser-induced breakdown spectroscopy (LIBS), Am. Lab. (2003)
11 Copyright JCPDS - International Centre for Diffraction Data 2005, Advances in X-ray Analysis, Volume [10] P. G. Kotula, M. R. Keenan, and J. R. Michael, Automated Analysis of SEM X-ray Spectral Images: A Powerful New Microanalysis Tool, Microsc. Microanal. 9 (2003) 1-17.
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Club Cubase in Tampa
Sam Ash Tampa
Thursday, March 29, 2012 at 7:30 PM (EDT)
Event Details
Club Cubase Tampa is pleased to announce their next meeting to be held on March 29 at 7:30 p.m. at Sam Ash Music in Tampa. This month Greg Ondo from Steinberg will be on hand to demonstrate the latest features in Cubase 6.5. This month we will take a detailed look at the new Cubase 6.5 including the Padshop and Retrologue VSTis, new comping tool, new audio quantize, SoundCloud, FLAC and 64bit Rewire.
Have questions about Club Cubase in Tampa? Contact Sam Ash Tampa
When & Where
Sam Ash Music
13133 No. Dale Mabry Hwy.
Thursday, March 29, 2012 at 7:30 PM (EDT)
Add to my calendar
Sam Ash Tampa
(813) 908-5556
Club Cubase in Tampa
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subset: commoncrawl


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MB Financial's (MBFI) "Buy" Rating Reiterated at Piper Jaffray Companies
MB Financial Inc. (NASDAQ:MBFI)'s stock had its "buy" rating reissued by equities research analysts at Piper Jaffray Companies in a report issued on Friday. They currently have a $49.00 target price on the bank's stock. Piper Jaffray Companies' price objective indicates a potential upside of 20.99% from the stock's current price.
A number of other analysts also recently weighed in on the company. BidaskClub downgraded MB Financial from a "hold" rating to a "sell" rating in a research note on Wednesday. Zacks Investment Research downgraded MB Financial from a "buy" rating to a "hold" rating in a research note on Saturday, July 8th. Wedbush restated a "neutral" rating and issued a $48.00 price target on shares of MB Financial in a research note on Tuesday, June 27th. Jefferies Group LLC restated a "hold" rating and issued a $48.00 price target on shares of MB Financial in a research note on Sunday, June 11th. Finally, ValuEngine downgraded MB Financial from a "buy" rating to a "hold" rating in a research note on Saturday, June 3rd. One investment analyst has rated the stock with a sell rating, seven have given a hold rating and four have given a buy rating to the company's stock. MB Financial currently has a consensus rating of "Hold" and an average price target of $48.63.
MB Financial (MBFI) traded down 4.84% during midday trading on Friday, reaching $40.50. The company's stock had a trading volume of 1,229,054 shares. The stock's 50 day moving average is $43.39 and its 200 day moving average is $43.69. MB Financial has a 12-month low of $35.00 and a 12-month high of $48.47. The stock has a market cap of $3.39 billion, a P/E ratio of 17.98 and a beta of 1.15.
MB Financial (NASDAQ:MBFI) last posted its quarterly earnings results on Thursday, July 20th. The bank reported $0.54 earnings per share for the quarter, missing the Zacks' consensus estimate of $0.64 by $0.10. MB Financial had a net margin of 19.64% and a return on equity of 8.37%. The business had revenue of $239.51 million during the quarter, compared to analysts' expectations of $247.39 million. During the same quarter last year, the firm earned $0.58 earnings per share. Analysts anticipate that MB Financial will post $2.64 earnings per share for the current year.
In other MB Financial news, Director James N. Hallene sold 4,877 shares of the business's stock in a transaction on Friday, June 9th. The stock was sold at an average price of $44.40, for a total transaction of $216,538.80. Following the sale, the director now directly owns 25,339 shares in the company, valued at $1,125,051.60. The transaction was disclosed in a document filed with the SEC, which can be accessed through the SEC website. Also, insider Mitchell Feiger sold 11,825 shares of the business's stock in a transaction on Tuesday, May 16th. The stock was sold at an average price of $43.60, for a total value of $515,570.00. Following the sale, the insider now owns 140,724 shares in the company, valued at $6,135,566.40. The disclosure for this sale can be found here. Over the last quarter, insiders have sold 21,702 shares of company stock worth $943,609. 7.05% of the stock is owned by company insiders.
A number of hedge funds have recently bought and sold shares of the company. Victory Capital Management Inc. increased its stake in MB Financial by 77.2% in the second quarter. Victory Capital Management Inc. now owns 3,130 shares of the bank's stock worth $114,000 after buying an additional 1,364 shares during the last quarter. Tyers Asset Management LLC purchased a new stake in MB Financial during the fourth quarter worth approximately $124,000. Credit Agricole S A purchased a new stake in MB Financial during the fourth quarter worth approximately $154,000. Huntington Asset Advisors Inc. purchased a new stake in MB Financial during the first quarter worth approximately $165,000. Finally, BlackRock Inc. increased its stake in MB Financial by 140.4% in the first quarter. BlackRock Inc. now owns 5,156 shares of the bank's stock worth $168,000 after buying an additional 3,011 shares during the last quarter. Institutional investors own 74.34% of the company's stock.
About MB Financial
MB Financial, Inc (MB Financial) is a financial holding company. The Company's segments include banking, leasing and mortgage banking. As of December 31, 2016, the Company's primary market was the Chicago metropolitan area, in which the Company operated 95 banking offices through its bank subsidiary, MB Financial Bank, N.A.
Receive News & Ratings for MB Financial Inc. Daily - Enter your email address below to receive a concise daily summary of the latest news and analysts' ratings for MB Financial Inc. and related companies with MarketBeat.com's FREE daily email newsletter.


text:
The Metropolitan Museum of Art offers two fellowships annually to scholars studying Cubism or a related topic. One position is intended for a predoctoral candidate who is embarking on his or her dissertation; the other fellowship is reserved for a qualified postdoctoral scholar at any stage of his or her career and may be one or two years in duration. All Lauder Fellows are expected to contribute to the activities and programming of the Leonard A. Lauder Research Center for Modern Art.
All predoctoral fellows must be in residence at the Metropolitan Museum during the fellowship period.
All predoctoral fellowships must take place between September 1, 2017, and August 31, 2019.
All postdoctoral fellowships must take place between September 1, 2017, and (depending on the length of the fellowship) August 31, 2018, or August 31, 2019.
The stipend amount for one year is $55,000 for postdoctoral fellows and $45,000 for predoctoral fellows.
During the fellowship period and at the Museum's discretion, Leonard A. Lauder Fellows will be eligible to receive one or more travel stipends.
All applications must be submitted online and in English. We will not accept applications or related materials via email, postal mail, or in person.
The online application will require you to provide the following:
1. Documents as Microsoft Word or PDF files:
2. Contact information for three recommenders (at least one academic and one professional), none of whom may be current Metropolitan Museum of Art staff. Once you have submitted your recommenders' names, titles, and email addresses, they will automatically be emailed instructions for uploading their letters online. Please note that each letter must include the recommender's complete title and contact information. We encourage recommenders to submit letters in English.
The deadline for all application materials, including transcripts and letters of recommendation, is November 4, 2016, at 5 pm (ET).
If you have any questions about the application process, please contact us.
All applicants for the 2017–2019 term will be notified by February 24, 2017.


text:
|Message view
|« Date » · « Thread »
|« Date » · « Thread »
|Dain Sundstrom <d...@coredevelopers.net>
|Re: [General] Container interface and AbstractContainer
|Thu, 14 Aug 2003 17:33:06 GMT
I'm going to respond to the original message as I think it got a little off track. On Thursday, August 14, 2003, at 02:22 AM, Jan Bartel wrote: > Dain, Jeremy et al, > > I am working on the AbstractWebContainer and having difficulty making > progress given the current form of the > org.apache.geronimo.common.Container. I'd like to make an > AbstractContainer class but here are the issues that I face in trying > to accomplish that: AbstractContainer was not designed to be implemented by things like a web server; it was designed to be managed collection of instances and services for those instances. Further the instances can be invoked. It would be more property named RPCContainer. I would see the web server implementing component and maybe some other interfaces. > 1. Why does Container already contain deprecated methods?! Can't these > be removed, they're kinda cluttering up the codebase. It was designed to be used today, and since the base services were not MBeans, so I could not use ObjectName. The plan is to make everything mbeans and remove the get depreciated methods. > 2. Is it really necessary that it has the method invoke(Invocation)? > Doesn't this pre-suppose that there is some de-typed mode of > communicating to/between containers like JMX? Couldn't this method be > moved into another subclass, say something like "InvokableContainer" > or something? Yes, it was designed to be an RPCContainer. We could make a interface that has that. > 3. Are the get/addPlugin() methods really necessary to have in the > base interface type? Again, couldn't these be handled by subclassing > from AbstractContainer? How would someone add a plugin if we did not have these methods. > I propose that the Container interface looks like: > Container extends Component > Components[] getComponents() > setComponents(Component[]) > addComponent(Component) > removeComponent(Component) > > In other words, a standard implementation of the Composite pattern. > Other subclasses can then treat the Components as Plugins, Invokers or > whatever. I know the array vs list thing was hotly debated, and my opinion just to throw it out there is to use only collections interfaces like Collection, List, Set, and Map. What I don't see is a need to return all the plugins. Is there an actual use case or is this just for debugging? If it is for just debugging, I suggest we return an immutable copy (snapshot) of our collection to avoid synchronization problems. > I also propose that the Component interface has one extra method: > > String getObjectName(); > > which is the identity of the Component, and will help out Containers > wishing to maintain maps of Components. It will also gel nicely with > the > JSR077 requirement to identify ManagedObjects by a name. Agree. -dain
|View raw message


text:
Need custom wordpress website
Budget $30 USD
Hey folks,
1. I am abit short of time and hence needed someone who can start work right now and finish the website by maximum 6-7 hours.
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text:
Facebook is rolling out 360-degree photos, so you'll be able to fully appreciate panoramic photos taken on a phone or a 360-degree camera.
If you don't happen to have a virtual reality headset to hand, you can tilt your phone to look around. On a Samsung phone, when you're viewing a 360 photo, there will be a button in the top left hand corner of the screen that says "View in VR."
It seems strange that it's taken so long for still pictures to catch up, as 360-degree videos have been supported by Facebook for some time. In fact, Oculus' announcement mentioned that nearly 80% of people who use the Gear VR watch video content on a given day.
Oculus also highlighted the release of new content for Gear VR, including a three-part series called Nomads and Deadliest Catch VR.


text:
The Way of The Temacu and Other Episodes is a fan-fiction VHS/DVD Release featuring one The New Adventures of Lara Laramie episode, one The New Adventures of Winnie The Pooh episode, one Sonic X episode, one The Adventures of Super Mario Bros. 3 episode, one Thomas and Friends episode, one Charmaine and Latoya episode, one Dexter's Laboratory episode and one Franklin episode.
- The Way of The Temacu (The New Adventures of Lara Laramie)
- Eeyore's Tail Tale (The New Adventures of Winnie the Pooh)
- Cruise Blues (Sonic X)
- Up, Up and A Koopa (The Adventures of Super Mario Bros. 3)
- Thomas' Tricky Tree (Thomas and Friends)
- A Very Big and Gigantic Girl (Charmaine and Latoya)
- Dream Machine (Dexter's Laboratory)
- Franklin Is Lost (Franklin)
- Distributed by USA Home Entertainment.
VHS/DVD Artwork
Front Cover
- Top: Temacu (in mizuho's clothes)
- Bottom: Sonic from "Cruise Blues"
Back Cover
- Charmaine Jr. from "A Very Big and Gigantic Girl"
- Thomas from "Thomas' Tricky Tree"


text:
Roseville's Credit Rating Raised
Standard & Poor's Ratings Services raised its credit rating on the City of Roseville one notch to 'AA+' from 'AA' in its latest review published April 1st.
The upgrade is based on Roseville's strong economy, strong budget flexibility and strong budget management according to Standard & Poor's.
This credit rating upgrade has the potential to save the City hundreds of thousands of dollars with future bond issuances.
The debt service savings to the City on the issuance of $35 million in bonds would be $500,000.


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Unfortunately for me (and it seems like for many of you as well) the acne returned
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I am charting now, but last month I didnt
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Somit ist Tadalafil der am lngsten wirkende PDE-5-Hemmer
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I certainly enjoyed the challenges
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While I was trying to blame the insomnia for driving me nutty, the depression was actually causing the sleepless nights.
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I also started with 50mg, but didn't ovulate so took a month off, then the next month was put on 100mg and I got pregnant..
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I am a veteran and have always been able to get Wyeth Effexor"until a move and a new pharmacist
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So this must be effecting a lot of people..
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Sometimes the grass isn't always greener on the other side
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I should add that even when I used to take Nexium every day, I had the stomach gurgling/very odd taste in my throat.