text:
Vamp Jing with sword by xMystery21xWatch
©2010-2017 xMystery21x
Vamp Jing A. Cane drawing his under sleeve sword before an enemy XP
*colored pencil
*colored pencil
It's Jing!!! I love that anime! hehe It's been forever since I've seen it though
i know right!? only 17 episodes & 1 movie!?!?! plus i jus finished bk 7 of the "twilight tales" XP
really cool :3
nicely done ^^
nicely done ^^
you colored him
yep, didn't do the background tho :/
lol xD awesome pic i luv how you did his hair and sleeve sword
lol xD awesome pic i luv how you did his hair and sleeve sword
ty, it was tough color choices... had togo w/ black, white, & silver for his hair XP
wow, can't believe people still made art of this show. this brings back so many memories. lol. thanks for bringing me back to my happier times. :3 you just made my day... correction, you made my week.
lol ty, & its 1 of my top fav animes/ mangas too! XD
lol. wish the series kept going. the series was too short.
so very tru T_T
lol. have you heard of Elemental Gelade? that show is just as good. :3 although it has a little more romance than King of Bandit Jing.


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To learn more or apply to volunteer or intern with Mundo Exchange just fill in this initial application form. Let us know how you would like to help. We will then contact you and send you additional information and our Second Application.
How to Apply to Volunteer with Mundo Exchange
Mundo Exchange VOLUNTEER PROJECTS IN THAILAND
The volunteer application process with Mundo Exchange is simple but requires work on both the volunteers and your local hosts side to make your cross cultural exchange and experience in Thailand highly rewarding and meaningful to you and those you come to serve.
1. PREPARE by reading our volunteer and intern field reports and stories, view their volunteer photos, and read more about our partner's and Mundo Exchange's global community development work and vision at http://www.mundoexchange.org website. Write to former volunteers that have teamed with us.
2. APPLY to learn or commit to helping children, community aide projects and adults in Thailand and Guatemala. Fill out the application form as thoroughly as possible letting us know when you plan to come, what you would like to do and give us information that will lead to an ideal cultural exchange for you and for those you come to serve.
2. APPLICATION REVIEW takes place by local country team who review your application and then contact you with information about volunteer projects that they feel are important and that also match your volunteering needs, experiences and wants.
3. CONFIRM Confirm through phone and email – you let us know when you plan to come and we will tell you more about your projects. Just let us know when we can call you to discuss your volunteer experience in Thailand.
4. We will then send you an INVOICE asking you to pay 100 Euro set up fee for your placement, cross cultural orientation and training, Thai language and cooking lessons, two days of cultural outings to sites and to visit Thai families and friends, a bicycle and a way to get to your placements, welcome meals, cross cultural ceremonies, a place to stay, kitchen use, internet access, sponsorship with the Thai government obtaining needed paperwork and verification with schools, immigration and such for you to volunteer in Thailand.
If you would like to come to stop by and visit or help in our volunteer centre for 10 days to a month teaching English 4 to 7 hours per day you pay for your own expenses and there is no 100 Euro payment. You arrange for your accommodation, cultural outings and Thai language classes with guidance from us or decide to stay at our volunteer centre for a minimal fee.
For those wanting a cultural submersion a total of 300 Euro for a month and 100 Euro for additional months compensates your Thai team hosts for their time away from work and expertise. They will arrange your selected projects and/or home stays and let the local project hosts, children and adults know when you are coming. They will also prepare your sponsorship to help in Thailand with government officials, your accommodation, your orientation, and your cultural outings to see Thai sites and meet family and friends. (If for any reason you can not come on your selected date, you can change the date or send a friend or family member in your place. Please let us know of any changes at your earliest convenience for those you come to help will begin planning for your arrival.) What is not included is food and personal expenses.
5. We will send you all PRE-DEPARTURE INFORMATION For those selecting the cultural submersion we will send you contact information of former volunteers who have helped on various Thai projects, photos, team teaching information for those volunteers working with Thai teachers in English, Sports, or Computer classes, travel ideas, language lessons and more on your placement, orientation and cross-cultural outings.
All volunteers who complete their pre-arranged volunteer work will receive a certificate of completion. Your local association hosts from Global / World Exchange (Laekplian Lokgatat) and Mundo write reference letters for volunteers helping with our projects for one month or more. The letters have helped volunteers and interns get rewarding jobs and acceptance into prestigious universities.
Since Lokgatat is a Thai registered ngo charity and Mundo Exchange is a registered 501 c3 international cultural exchange NGO #87-0781320 your financial assistance, transportation and all other costs you spend coming and going may be tax deductible. Ask your financial advisor about this possibility.
We thank you for your interest in helping by volunteering and interning with our community empowerment projects! We look forward to working together with you in Thailand.
Whether you volunteer with us or not, we welcome you to stop by, visit and meet our Thai team and local hosts. Just use our Contact Form or call us in Thailand at +660899658762.
Guatemala Projects usually happen twice a year and speaking Spanish at a above average level is required. We go with small family, school or team groups up into the mountains to help with community development projects with our Mayan friends. Joan Williams has been working with these people for years, starting when she helped to recover bodies from mass graves. Although the war is over the poverty and need for assistance is great. Please contact us if this volunteer project is of interest to you.

subset: commoncrawl


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SEBI found that Shubham Karoti Foods was collecting money from common people in Silvassa through certain food schemes without due authorisation
Market regulator Securities and Exchange Board of India (SEBI) has barred Pune-based Shubham Karoti Foods Pvt Ltd and its two directors from mobilising money from investors and launching any new scheme.
The capital market regulator found that the company was collecting funds from common people in Silvassa through certain food schemes without due authorisation.
The Pune-based company is stated to be engaged in the business of food products including tea, groundnut, soya oil, mineral water, among others in Maharashtra.
"Protecting the interests of investors is the first and foremost mandate for SEBI and therefore steps have to be taken in the instant matter to ensure only legitimate investment activities are carried on by Shubham Karoti Foods and no investors are defrauded," the SEBI said in an order.
Accordingly, SEBI has directed the company and its directors -- Somit Kishanchandra Saxena and Sudhir Nathuram Pawar "not to collect any more money from investors including under the existing schemes" and "not to launch any new schemes".
Besides, the entities have been asked not to dispose of any of the properties or alienate any of the assets of the schemes and not to divert any funds raised from public.
The company has to furnish all information regarding the schemes with details of the investors and also details of insurance policies and compensation given under the policies as part of the schemes, to SEBI.
The directions shall take effect immediately and shall be in force until further orders, SEBI said.
The regulator said that the company "is prima facie engaged in mobilising funds from the public, by floating or sponsoring or launching 'collective investment scheme...without obtaining a certificate of registration from SEBI".
SEBI had begun a probe in the matter after receiving a reference on 20 November 2013 from the Reserve Bank of India (RBI) about the company.
The common denominator in all bank frauds is the lack of internal control, lack of integrity and the epidemic of misconduct among officials
Experience is the best educator, but it seems that some people refuse to learn, the latest culprit in this category being a multinational bank. It is the latest addition to the endless list of fraudsters. This bank's fraud has a striking similarity to the Allied Irish Banks (AIB) and Barings Bank cases, in both instances one man incurred huge losses without any other person within the organisation getting wind of it. Barings Bank collapsed as a result and AIB barely survived the debacle.
The similarities are in the manner the funds were invested. Rusnak of AIB was a currency trader who gambled on the world's financial markets and incurred huge losses.
A combination of incompetence, ignorance and ineptitude, coupled with little or no supervision and internal control, enabled him to do what he did. It was after about a year had passed that the trader's actions came to bite the bank and it lost about 10% of its equity capital, but somehow survived the ordeal.
Barings was not as lucky, Nick Leeson was trader with Baring and in 1995 went one step further than Rusnak and ended up bringing down Barings, the UK's oldest merchant bank. Leeson was dealing in dodgy derivatives rather than currencies, this case had a striking resemblance to the AIB debacle. Shivraj Puri, the alleged mastermind behind a fraud worth about Rs400 crore, more or less operated as Leeson did. Like Leeson, he also invested most of the funds in the derivative instrument called "Nifty Options".
Sumitomo Bank's Yazoo Harmonica, Daiwa Bank's bond trader Toshihide Iguchi, Princeton Economics International's Martin Armstrong and the list is endless, but the common denominator in all frauds is the lack of internal control within banks, lack of integrity and an epidemic of misconduct among officials.
It is estimated that a typical organisation in the US loses 6% of its annual revenue to fraud and that employees are responsible for more than 75% of the fraudulent transactions. Shivraj Puri's fraudulent operations, which became public in 2012, brought to light a bank with a "lack of integrity, no compliance, discipline and transparency, no due diligence and no strategy".
Most, if not all of the factors that contribute to fraud, can be neutralised with strong internal checks and controls. The essence of 'Internal Control' therefore lies in the separation of the three functions of 'Authorisation'- the initiation of the transaction, 'Custody'- the handling of assets involved in the transaction' and 'Recording'- the creation of documentary evidence of the transactions and it's entry in the accounting records.
This will involve the division of responsibility in the various procedures, whereby, transactions are Authorised, Performed, Recorded and on completion are Verified and Reconciled independently.
Know your customer (KYC), an essential precaution, must be coupled with know your employees (KYE):
Thorough check on employees' credentials, proper screening of candidates to prevent hiring fraudsters
Rotation of personnel, surprise job rotation
Compulsory annual leave
Competent personnel
Assignment of responsibility
Division of work /Separation of Functional duties
Separation of accountability from custodianship
Adequate records and equipment
Physical protection of assets
Strong Internal and external auditing
These imply that the financial and accounting controls should be such as to facilitate efficient working and at the same time obviate any chance of Fraud or error. Here the practical division of duties should be such as to ensure that the internal check system is operating at all stages. Internal Check forms a valuable part of the Internal Control System. It arises from the "Separation of Function" in such a manner that no single task is executed from it's beginning to its final destination by any one person and the work of each person is an independent check in the course of another person's duties. "Internal Check" is a form of "Verification" that aims at minimizing errors and frauds. It is a line function.
The failures in several recent cases, demonstrate that inadequate internal controls can lead to significant losses for banks. The types of control breakdowns typically seen in these cases can be grouped into the following categories:
Lack of management supervision, accountability and failure to develop a strong control culture within the bank.
Inadequate recognition and assessment of the risk of certain banking activities, whether on or off balance sheet
Key control structures and activities, such as segregation of duties, approvals
verification, reconciliation and review of operating performance.
Inadequate communication of information between levels of management within the bank, especially in the upward communication of problems.
Inadequate or ineffective audit programs and monitoring activities.
It is a fact that an organization implementing and maintaining a robust internal control system would, in most cases, prevent any fraud. If banking organisations do not go down that road, it is inevitable that they will be more prone to fraud. A good internal control system will keep any damage down to a minimum. Organisations should try to develop a culture that constantly accounts for ethical questions in its functions.
(Saiyid (SSA) Zaidi is a training and development consultant as well as external subject matter expert at the Educom Group Banker's Academy in New York.)
Have you ever spotted a suspect "like" on your Facebook profile, especially a sponsored advertisement carrying a 'like' endorsement from your friend?
My friend doesn't drive a Subaru. So when I saw a Facebook ad for a Subaru dealership with his endorsement, I had to wonder: What's up with the Jetta?
The sponsored ad appeared on the right side of my homepage where, as of this article, Facebook also presents events, birthdays, and "trending" news articles.
Sponsored ads sometimes carry a friend's endorsement in the form of a "Like" of the company's Facebook page, and that was the case with the Subaru ad.
But knowing my friend drove a Volkswagen, I had to ask: Did you really like this page for a dealership in Stamford, Connecticut. His text back: What?!! Why would I like Subaru?
As the happy owner of a Subaru myself — which I imagine was why the ad had surfaced in the first place? — I could have given him a few reasons, but that was beside the point.
Earlier this year, a class-action lawsuit against the social media behemoth alleged that Facebook unlawfully misrepresents its users by liking pages without their knowledge or consent, and in doing so creates "a false impression that its customers are promoting a particular company or product."
The three plaintiffs each cited a page that they alleged Facebook liked without their permission – the three company pages belonging to USA Today, Duracell, and Kohl's. In the cases of USA Today and Duracell, the likes were featured in sponsored ads visible to Facebook friends, the complaint alleged.
The lawsuit sought millions of dollars in punitive damages for the millions of Facebook users potentially affected by the alleged unauthorized endorsements. But in a motion to dismiss, Facebook called the claims "baseless" and argued that the plaintiffs probably liked the pages and forgot or "inadvertently" clicked the like button on Facebook or elsewhere.
Less than five months after the suit was filed in January, the three plaintiffs dropped their case in May. And they withdrew it with prejudice, meaning the case can't be brought back to court. The reason for the withdrawal was not made public.
TINA.org reached out to Facebook for comment on the case and its outcome but did not receive a response.
Courtesy: TruthInAdvertising.org


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Famed German auteur Wim Wenders is back at Cannes this year with a thriller called Palermo Shooting, about a photographer who flees his home in Germany and settles into a new life in Italy, which is getting all sorts of early buzz.
THR sat down with Wenders to discuss his career so far, and towards the end of their chat the director revealed that his next project will be a horror film called Miso Soup. "It is going to be very exciting. Horror is one genre that is used much less than others to transport other things," Wenders told the trade. "Lots of people have used great thrillers to transport political messages, but the horror film is rarely used to transport anything but fear."
I don't know if that's necessarily true at all, but whatever helps you sleep at night, I guess. Though Wenders didn't reveal anything about the plot, he did say it was based on a famous Japanese novel, which could be Ryu Murakami's In the Miso Soup, about a tour guide in Tokyo who has to deal with an insane man with superhuman strength who may or may not be dismembering local homeless men and schoolgirls.
I hope that's what it's based on; I want to see that as a film! The only other piece Wenders revealed was that Willem DaFoe is attached to star, and shooting will go down in Tokyo next spring. We'll hand you more details when we find 'em!
Discuss the many messages horror helps convey in the Dread Central forums!


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- Manufacturer: Alpinestars
Alpinestars Charger Backpack
- Combination nylon and polyester construction.
- Sport silhouette engineered for a low profile aerodynamic performance while riding.
- 17 litre capacity with internal laptop sleeve pocket to accommodate most 15" computers.
- Water resistant fleece lined audio pocket with headphone exit port.
- Internal organizer pockets keep personal items accessible.
- Built-in helmet carrier.
- Anatomical, adjustable, padded shoulder straps with chest connection strap for additional security and comfort and quick release connection for convenience.
- Adjustable waist strap for security which also features built-in kidney pockets.
- TPR (thermoplastic rubber) and embroidered logo details.
- Waterproof, YKK auto-locking, one-way only, zip to ensure weather protection and secure closure while riding.


text: etd@IISc Collection: http://hdl.handle.net/2005/9 2017-03-20T16:17:14Z Fidelity Of Translation Initiation In E. coli : Roles Of The Transcription-recycling Factor RapA, 23S rRNA Modifications, And Evolutionary Origin Of Initiator tRNA http://hdl.handle.net/2005/2574 Title: Fidelity Of Translation Initiation In E. coli : Roles Of The Transcription-recycling Factor RapA, 23S rRNA Modifications, And Evolutionary Origin Of Initiator tRNA Authors: Bhattacharyya, Souvik Abstract: Translation initiation is a rate limiting step during protein biosynthesis. Initiation occurs by formation of an initiation complex comprising 30S subunit of ribosome, mRNA, initiator tRNA, and initiation factors. The initiator tRNA has a specialized function of binding to ribosomal P site whereas all the other tRNAs are selected in the ribosomal A site. The presence of a highly conserved 3 consecutive G-C base pairs in the anticodon stem of the initiator tRNA has been shown to be responsible for its P-site targeting. The exact molecular mechanism involved in the P-site targeting of the initiator tRNA is still unclear and focus of our study. Using genetic methods, we obtained mutant E. coli strains where initiator tRNA mutants lacking the characteristic 3-GC base pairs can also initiate translation. One such mutant strain, A30, was selected for this study. Using standard molecular genetic tools, the mutation was mapped and identified to be a mutation in a transcription remodeling factor, RapA (A511V). RapA is a transcription recycling factor and it displaces S1 when it performs its transcription recycling activity. We found this mutation to cause an increase in the S1-depleted ribosomes leading to decreased fidelity of translation initiation as the mutant RapA inefficiently displaces S1 from RNA polymerase complex. The mutation in the RapA was also found to cause changes in the transcriptome which leads to downregulation of major genes important for methionine and purine metabolism. Using mass spectrometric analysis, we identified deficiencies of methionine and adenine in the strain carrying mutant RapA. Our lab had previously reported that methionine and S-adenosyl methionine deficiency cause deficiency of methylations in ribosome which in turn decreases the fidelity of protein synthesis initiation. We used strains deleted for two newly identified methyltransferases, namely RlmH and RlmI, for our study and these strains also showed decreased fidelity of initiation. RlmH and RlmI methylate 1915 and 1962 positions of 23S rRNA respectively. We found that deletion of these methyltransferases also caused defects in ribosome biogenesis and compromised activity of ribosome recycling factor. We constructed phylogenetic trees of the initiator tRNA from 158 species which distinctly assembled into three domains of life. We also constructed trees using the minihelix or the whole sequence of species specific tRNAs, and iterated our analysis on 50 eubacterial species. We identified tRNAPro, tRNAGlu, or tRNAThr (but surprisingly not elongator tRNAMet) as probable ancestors of tRNAi. We then determined the factors imposing selection of methionine as the initiating amino acid. Overall frequency of occurrence of methionine, whose metabolic cost of synthesis is the highest among all amino acids, remains almost unchanged across the three domains of life. Our results indicate that methionine selection, as the initiating amino acid was possibly a consequence of the evolution of one-carbon metabolism, which plays an important role in regulating translation initiation. In conclusion, the current study reveals the importance of methylations in ribosome biogenesis and fidelity of translation initiation. It also strongly suggests a co-evolution of the metabolism and translation apparatus giving adaptive advantage to the cells where presence of methionine in the environment can be a signal to initiate translation with methionine initiator tRNA. 2016-09-14T18:30:00Z Mechanistic And Functional Insights Into Mycobacterium Bovis BCG Triggered TLR2 Signaling : Implications For Immune Evasion Strategies http://hdl.handle.net/2005/2479 Title: Mechanistic And Functional Insights Into Mycobacterium Bovis BCG Triggered TLR2 Signaling : Implications For Immune Evasion Strategies Authors: Ghorpade, Devram Sampat Abstract: Mycobacteria are multifaceted pathogens capable of causing both acute disease as well as an asymptomatic latent infection. Host immune responses during mycobacterial infection involve potent cell effector functions including that of CD4+, CD8+ and γδT cells, macrophages and dendritic cells (DCs). Further, the critical regulators of protective immunity to mycobacterial infection include IFN-γ, IL-12, IL-23, TNF-α, lymphotoxins, CD40, nitric oxide and reactive oxygen species. However, the success of mycobacterial infection often relies in its ability to evade immune surveillance mechanisms mediated by sentinels of host immunity by modulating host signal transduction pathways and expression of immunoregulatory molecules. Therefore, the key to control mycobacterial growth and limit pathogenesis lies in the understanding the interactions between Mycobacterium and primary responders like macrophages and DCs. In this scenario, the role of pattern recognition receptors (PPRs) in orchestrating host immune responses assumes central importance. The cell surface receptors play crucial role in influencing overall immune responses. Of the PRRs, the Toll-like receptors (TLRs) form key immune surveillance mechanisms in recognition as well as control of mycobacterial infection. Among them, TLR2 is the primary interacting receptor on antigen presenting cells that recognize the invading mycobacteria. Mycobacterial cell wall constituents such as LAM, LM, PIM and 19-kDa protein have been shown to activate TLR2 signaling leading to proinflammatory responses. Recent reports have suggested that PE_PGRS antigens of M. tuberculosis interact with TLR2. For example, RV0754, Rv0978c, RV1917c have been implicated in modulation of human DCs. The 19-kDa lipoprotein, LpqH (Rv3763) and LprG (Rv1411c) utilize TLR2 signaling to inhibit macrophage responsiveness to IFN-γ triggered MHC class II expression and mycobacterial antigen presentation. Interestingly, recognition and amplification of pathogenic-specific signaling events play important roles in not only discriminating the invading microbes, but also in regulating explicit immune responses. In this context, integration of key signaling centers, which modulate host immunity to pathogenic mycobacterial infections, remains unexplored. In accordance to above observations, signal transduction pathways downstream to TLRs play a critical role in modulation of battery of host cells genes in terms of expression and production of immune modulatory cytokines and chemokines, recruitment of cellular machineries to site of infections etc. This suggests the decisive role for TLRs in modulation of host cell fate decisions. However, during the ensuing immunity to invading pathogens, beside TLR signaling pathways, various other signaling molecules are thought to execute specific functions in divergent cellular contexts. Recent studies from our laboratory have clearly demarcated a novel cross talk of TLR2-NOTCH1 and TLR2-Wnt signaling pathways during mycobacterial infections. The current study primary focuses on the broad range of cross talk of TLR2 and Sonic hedgehog (SHH) signaling pathways and its functional significance. The present investigation demonstrates that M. bovis BCG, a vaccine strain, triggers a robust activation of SHH signaling in macrophages compared to infection with diverse Gram-positive or Gram-negative microbes. This observation was further evidenced by the heightened SHH signaling signatures during in vivo scenario in cells /tissues from pulmonary tuberculosis (TB) individuals as well as tuberculous meningitis (TBM) patients. Furthermore, we show that the sustained TNF-α secretion by macrophages upon infection with M. bovis BCG is a critical necessity for SHH activation. Significantly, perturbation studies implicate a vital role for M. bovis BCG stimulated TLR2/PI3K/PKC/MAPK/NF-κB axis to induce TNF-α, that contributes to enhance SHH signaling. The TNF-α driven SHH signaling downregulates M. bovis BCG induced TLR2 signaling events leading to modulation of battery of genes that regulate various functions of macrophages genes like Vegf-a, Socs-3, Cox-2, Mmp-9 and M1/M2 genes. Importantly, utilizing whole-genome microRNA (miRNA) profiling, roles for specific miRNAs were identified as the molecular regulators that bring about the negative-feedback loop comprising TLR2-SHH signaling events. Thus, the current study illustrates how SHH signaling tightly regulates the kinetics and strengths of M. bovis BCG specific TLR2 responses, emphasizing a novel role for SHH signaling in host immune responses to mycobacterial infections. As described, variety of host factors contributes for ensuing effective host defenses and modulation of host cell fate decisions. Interestingly, avirulent pathogenic mycobacteria, including the vaccine strain M. bovis BCG, unlike virulent M. tuberculosis, cause extensive apoptosis of infected macrophages, which suggests a significant contribution of the apoptosis process to the initiation and subsequent amplification of innate as well as adaptive immune responses. Among various cues that could lead to apoptosis of host cells, the initiation of the apoptotic machinery by posttranscriptional mechanisms assumes significant importance. Among posttranscriptional control mechanisms, miRNAs are suggested to regulate several biological processes including immune responses. Various effectors of host immunity are known to be regulated by several miRNAs, and a prominent one among them, miRNA-155 (miR-155), often exhibits crucial roles during innate or adaptive immune responses. In this perspective, we identified a novel role of miR-155 during M. bovis BCG induced apoptosis of macrophages. The genetic and signaling perturbations data suggested that miR-155 regulates PKA signaling by directly targeting a negative regulator of PKA, protein kinase inhibitor alpha (PKI-α). Enhanced activation of PKA signaling resulted in induced expression of the apoptotic genes as well as Caspase-3 cleavage and Cytochrome c translocation. Thus, augmented PKA signaling by M. bovis BCG-driven miR-155 dictates cell fate decisions of infected macrophages, emphasizing a novel role for miR-155 in host immunity to mycobacterial infections. In perspective of these studies, important directives are often comprised of sequential and coordinated activation of TLR and NLR-driven signal transduction pathways, thus exhibiting foremost influence in determining the overall strength of the innate immune responses. As described, TLR2 exhibits dominant role in sensing various agonists including pathogen-associated molecular patterns (PAMPs) of microbes at the cell surface and generally considered as major effectuator of proinflammatory responses. Interestingly, NLRs like NOD1 or NOD2 often act in contrary, thus regulating anti-inflammatory responses as well as polarization of T cells towards skewed Th2 phenotype. This presents an interesting conundrum to functionality of DCs or macrophages in terms of effector functions during rapidly evolving immunological processes including effects originating from immunosuppressive effectors such as CTLA-4 or TGF-. DCs like macrophages are important sentinels of innate immunity, possesses array of PRRs that include TLRs and NOD-like receptors (NLRs). Signaling events associated with innate sensors like TLRs and NLRs often act as regulatory circuits that modulate the overall functions of DCs in terms of maturation process, cytokine or chemokine production, receptor expression, migration to secondary lymphoid organs for antigen presentation for effectuating Th polarization. TLR2, while acting as sensors for extracellular cues or endocytic network, drives signaling events in response to recognition of PAMPs including mycobacterial antigens like ESAT-6, PE_PGRS antigens, while NOD1 and NOD2 operate as cytosolic sensors initiating signaling pathways upon recognition of diaminopimelic acid (DAP) and muramyl dipeptide (MDP), components of bacterial peptidoglycan. Thus, TLRs or NOD receptors could trigger similar or contrasting immune responses by cooperative or non-cooperative sensing, consequently exhibiting immense complexity during combinatorial triggering of host DCs-PRR repertoire. In view of these observations, our current investigation comprehensively demonstrated that maturation process of human DCs were cooperatively regulated by signaling cascades initiated by engagements of TLR2, NOD1 and NOD2 receptors. Importantly, combined triggering of TLR2 and NOD receptors abolished the TGF-β or CTLA-4-mediated impairment of human DCs maturation, which required critical participation of NOTCH1-PI3K signaling cohorts. Thus, our data delineated the novel insights in modulation of macrophages and DCs effector functions by mycobacterial TLR2 or NOD agonists and broaden our understanding on the signal dynamics and integration of multiple signals from PRRs during mycobacterial infections. Altogether, our findings establish the understanding of conceptual frame work in fine tuning of TLR2 responses by SHH signaling as well as potential co-operativity among TLRs and NODs to modulate NOTCH1 dependent DCs maturation. Importantly, our study provides mechanistic and functional insights into various molecular regulators of macrophage cell fate decisions like miR-31. miR-150 and miR-155, which can fuel the search for attractive and effective drug targets and novel therapeutics to combat diseases of the hour like tuberculosis. 2015-09-03T18:30:00Z Studies On Phosphorylation And Oligomerization Of Rotavirus Nonstructural Protein 5 (NSP5) And Cellular Pathways That Regulate Virus Replication http://hdl.handle.net/2005/2526 Title: Studies On Phosphorylation And Oligomerization Of Rotavirus Nonstructural Protein 5 (NSP5) And Cellular Pathways That Regulate Virus Replication Authors: Namsa, Nima Dondu Abstract: Rotavirus is one of the leading etiological agents of gastroenteritis in young of many species including humans worldwide and is responsible for about 600,000 infant deaths per annum. Rotavirus belongs to the Reoviridae family, and its genome is composed of 11 double-stranded RNA segments that encode six structural proteins and six nonstructural proteins. Rotavirus replication is fully cytoplasmic and occurs within highly specialized regions called viroplasms. NSP2 and NSP5 have been shown to be essential for viroplasm formation and, when co-expressed in uninfected cells, to form viroplasm¬like structures. A recent study suggest a key role for NSP5 in architectural assembly of viroplasms and in recruitment of viroplasmic proteins, containing four structural (VP1, VP2, VP3 and VP6) and two nonstructural (NSP2 and NSP5) proteins. NSP5, the translation product of gene segment 11 has a predicted molecular eight of 21 kDa. NSP5 has been reported to exist in multiple isoforms ranging in size from 28-and 32-35 kDa from a 26-kDa precursor has been attributed to O-glycosylation and hyperphosphorylation. To study different properties of the protein, recombinant NSP5 containing an N-terminal hisidine tag was expressed in bacteria and purified by affinity chromatography. A significant observation was the similarity in phosphorylation property of the bacterially expressed and that expressed in mammalian cells. While the untagged recombinant protein failed to undergo phosphorylation in vitro, addition of His tag or deletions at the N-terminus promoted phosphorylation of the protein in vitro, which is very similar to the reported properties exhibited by the corresponding proteins expressed in mammalian cells. Phosphorylation of NSP5 in vitro is independent of the cell type from which the extract is derived suggesting that the kinases that phosphorylate NSP5 are distributed in all cell types. Among the C-terminal deletion mutants studied, NH-∆C5 and NH-∆C10 were phosphorylated better than full-length NSP5, but NH-∆C25 and NH¬∆C35 showed substantial reduction in the level of phosphorylation compared to full-length NSP5. These results indicate that the C-terminal 30 residues spanning the predicted α-helical domain of NSP5 are critical for its phosphorylation in vitro which is in correspondence with previous findings that C-terminal 21 amino acids of NSP5 direct its insolubility, hyperphosphorylation, and VLS formation. The results revealed that though the tagged full-length and some of the mutants could be phosphorylated in vitro, they are not suitable substrates for hyperphosphorylation unlike the similar proteins expressed in mammalian cells or infected cells. Analysis by western blot and mass spectrometry revealed that the bacterially expressed NH-NSP5 is indeed phosphorylated. It appears that prior phosphorylation in bacteria renders the protein conformationally not amendable for hyperphosphorylation by cellular kinases in vitro. Mutation of the highly conserved proline marginally enhanced its phosphorylation in vitro but the stability of protein is affected. Notably, mutation of S67A, identified as a critical residue for the putative caesin kinase-I and-II pathways of NSP5 phosphorylation, affected neither the phosphorylation nor the ATPase activity of NSP5. These results suggest that bacterially expressed NSP5 by itself has undectable auto-kinase activity and it is hypophosphorylated. Purified recombinant NSP5 has been reported to possess an Mg¬ 2+-dependent ATP-specific triphosphatase activity. The results indicated that deletion of either C-terminal 48 amino acids or N-terminal 33 residues severely affected the ATPase activity of recombinant NSP5, underlying the importance of both N-and C-terminal domains for NSP5 ATP hydrolysis function. NSP5 expressed in rotavirus infected cells exists as inter-molecular disulfide-linked dimeric forms and it appears that the 46 kDa isoforms, that are phosphorylated, corresponds to dimer as revealed by western blotting. Analytical gel filtration analysis of NH-NSP5, NH-ΔN43 and NH-ΔN33-ΔC25 showed most of the proteins in void volume, but an additional peak corresponding to the mass of dimeric species further supports that NSP5 is basically a dimer that undergoes oligomerization. Analysis by sucrose-gradient fractionation revealed that NH-NSP5 and NH-ΔN43 proteins were mainly distributed in the lower fraction of the gradient suggesting the existence of high molecular weight complexes or higher oligomers. The multimeric nature of NSP5 and its mutants was further confirmed by dynamic light scattering which suggests that high molecular weight complexes are of homogenous species. The correlation curves showed a low polydispersity distribution and a globular nature of recombinant NH-NSP5 proteins. The present results clearly demonstrate that dimer is the basic structural unit of NSP5 which undergoes oligomerization to form a complex consisting of about 20-21 dimers. The nonstructural protein 5 is hyperphosphorylated in infected cells and cellular kinases have been implicated to be involved in its phosphorylation. NSP5 contains multiple consensus sites for phosphorylation by several kinases, but the cellular kinases that specifically phosphorylate NSP5 in infected cells are yet to be identified. Previous studies from our laboratory using signaling pathway inhibitors revealed that recombinant NH¬NSP5 and its deletion mutants can be phosphorylated in vitro by purified cellular kinases and by mammalian cell extracts. These studies also showed the involvement of PI3K-Akt and MAPK signaling pathways in NSP5 phosphorylation and a negative role for GSK3β in the phosphorylation of bacterially expressed recombinant NSP5 in vitro. In the present work, using phospho-specific anti-Ser9 GSK3β antibody, we observed that GSK3β is inactivated in a rotavirus infected MA104 cells in a strain-independent manner. GSK3β¬specific small interfering RNA (siRNA-GSK3β) reduced GSK3β levels leading to increased level of synthesis of the structural rotavirus protein VP6 and NSP5 hyperphosphorylation compared to control siRNA. The pharmacological kinase inhibitors (LY294002, Genistein, PD98059, and Rapamycin) studies at the concentrations tested did not significantly affect rotavirus infection as seen from the number foci, while U0126 severely affected rotavirus replication. The results clearly demonstrated the importance of the MEK1/2 signaling pathway in the successful replication of rotavirus and NSP5 hyperphosphorylation in rotavirus-infected cells. In contrast inhibition of GSK3β activity by LiCl, increased in general, the number of foci by greater than 2-fold for all viral strains studied. These results suggest that MEK1/2 pathway majorly contributes to GSK3β inactivation in rotavirus infected cells. Thus, our results reveal that rotavirus activates both the PI3K/Akt and FAK/ERK1/2 MAPK pathways and appears to utilize them as a strategy to activate mTOR, and inhibit GSK3β through phosphorylation on serine 9, the negative regulator of rotavirus NSP5 phosphorylation, and thus facilitate translational competence of rotaviral mRNAs during virus replication cycle. It was shown previously in the laboratory by co-immunoprecipitation assay that Hsp70 interacts with rotaviral proteins VP1 and VP4 in rotavirus-infected mammalian cells. In this study, the interactions between Hsp70 with VP1 and VP4 were further evaluated in vitro by GST-pull down assay. It was observed that the N-terminal ATPase and C-terminal peptide-binding domain of Hsp70 is necessary for its direct interaction with VP1 and VP4. The presence of Hsp70 in purified double-and triple-layered virus particles further supported the observed interactions of rotaviral proteins VP1 and VP4 with Hsp70. However, the specific interaction observed between Hsp70 and rotaviral capsid proteins, VP1 and VP4 in viral particles suggests that Hsp70 has an important role during rotavirus assembly which requires further investigation. 2016-04-27T18:30:00Z Molecular Characterisation Of Mycobacterium Tuberculosis Fic Protein And Its Gene And Identification And Characterisation Of A Novel Functional Interaction Between FtsZ And NDK in Mycobacteria http://hdl.handle.net/2005/2530 Title: Molecular Characterisation Of Mycobacterium Tuberculosis Fic Protein And Its Gene And Identification And Characterisation Of A Novel Functional Interaction Between FtsZ And NDK in Mycobacteria Authors: Mishra, Saurabh Abstract: Living organisms employ different kinds of mechanisms, to regulate the functions of genes or their products, which may help in maintaining homeostasis inside the cell or may help in fighting hostile environment in the case of pathogenic organisms. These mechanisms act at the transcriptional, post-transcriptional, translational, and post-translational levels. In order to understand the physiology of an organism, it is essential to obtain an in-depth knowledge of such mechanisms, in which several proteins participate in interlinked pathways. In this regard, the present study focuses on two such proteins: (i). the newly identified Fic (Filamentation induced by cAMP) protein; and (ii). NDK (Nucleoside Diphosphate Kinase), which had been studied for decades. Fic protein and NDK share several common features: (i). both use nucleoside triphosphate (NTPs) or nucleoside diphosphate (NDPs) or their derivatives as one of their substrates; (ii). they have been found to be involved in diverse cellular pathways, involving different types of substrates that form the second substrate of these proteins; (iii). both are ubiquitously present in all the living organisms - from bacteria to humans to plants. However, there is very little information on these proteins from mycobacterial systems, which include some major human pathogens, Mycobacterium tuberculosis and Mycobacterium leprae, which are the causative agents of Tuberculosis and Leprosy, respectively. In view of these reasons, in the present study, the structural and/or functional features of the Fic and NDK proteins from Mycobacterium tuberculosis, were analysed, as it might be of medical significance for effectively combating the pathogen. The Chapter 1 of the thesis contains the Introduction to the research work and Chapter 2 is on the overall Materials and Methods. The remaining chapters pertain to the data obtained on the structural and/or functional features of the Fic and NDK proteins from Mycobacterium tuberculosis. Chapter 3. Cloning, Expression and Purification of Mycobacterium tuberculosis Fic The role of FIC (Filamentation induced by cAMP) domain containing proteins in the regulation of many vital pathways, mostly through the transfer of NMPs from NTPs to specific target proteins (NMPylylation), in microorganisms, higher eukaryotes, and plants is emerging. In order to understand the biological role of FIC domain containing proteins in mycobacteria, the gene for the FIC domain containing protein of the human pathogen, Mycobacterium tuberculosis, MtuFic, was cloned, overexpressed, purified to homogeneity, and biochemically characterised. Neither the His-tagged nor the GST-tagged MtuFic protein, overexpressed in Escherichia coli, nor expression of Mtufic in Mycobacterium smegmatis, yielded the protein in the soluble fraction. However, the maltose binding protein (MBP) tagged MtuFic (MBP-MtuFic) could be obtained partly in the soluble fraction. Denatured-refolded protein was used for the antibody generation in mice and rabbit. The cellular localisation and secretion of MtuFic were characterised using the antibody. Chapter 4. Biochemical Characterisation of Mycobacterium tuberculosis Fic Sequence alignment with several FIC motif containing proteins, complemented with homology modeling on the FIC motif containing protein, VbhT of Bartonella schoenbuchensis as the template, showed conservation and interaction of residues constituting the FIC domain. MtuFic, possesses the critical His144 residue, in the characteristic FIC Motif, HPFREGNGRSTR (HPFxxGNGRxxR), spanning 144th to 155th residue. Site-specific mutagenesis of the His144, or Glu148, or Asn150 of the FIC motif, or of Arg87 residue that constitutes the FIC domain, or complete deletion of the FIC motif, abolished the NTP to NMP conversion activity. The activity of MtuFic was consistent with the biochemical activities hitherto reported for a variety of bacterial FIC domain containing proteins. Studies were also carried out on NMPylylation in the presence of eukaryotic proteins and eukaryotic and mycobacterial cell lysates. Although formation of NMPs from NTPs mediated by MBP-MtuFic could be detected, we could not identify any protein as the target substrate either in the human macrophage (THP1) cells or in the M. tuberculosis cells. VopSΔ30 (kind gift from Dr. Kim Orth), along with human G proteins as targets, were used as the positive controls. Various possibilities for the inability to detect a protein target substrate are discussed. Chapter 5. Transcriptional Analysis of Mycobacterium tuberculosis fic Gene (Mtufic) In parallel, in order to understand the transcriptional regulation of Mtufic, primer extension analysis was carried out. The Transcription Start Site (TSS; +1 site) of Mtufic were mapped under different growth/stress conditions, which tubercle bacilli encounter in human host. Mtufic got expressed mainly through two transcripts, T1 and T2, arising from two different transcription start sites (TSS). Putative promoter regions were cloned in a promoter probe vector, which expresses a GFP protein of very high intensity, in order to qualitatively detect the activity of the promoters. The half-life of the gfp mRNA was determined to be 4 min and therefore justifiably quantitated the Mtufic promoter activity by determining the gfp mRNA levels. The levels of Mtufic mRNA were two-fold higher under nutrient-depleted stationary phase of growth, as compared to the levels at mid-log phase. The activity of P1 and P2, as quantitated real-time using the short half-life gfpm2+ mRNA levels in Mycobacterium smegmatis transformants, showed that the activity of P2 was upregulated two-fold under nutrient-depleted stationary phase of growth, while that of P1 remained unaltered while of P1 and P2 were low under hypoxia. Co-transcription of Mtufic, with the immediate upstream gene, Rv3642c, of unknown function, was observed. Taken together, the data strongly indicated that the expression of Mtufic gets altered under nutrient-depleted and hypoxic conditions, which are the stress conditions experienced by tubercle bacilli in granuloma in tuberculosis patients. Chapter 6. Functional Characterisation of Mycobacterial FtsZ-NDK Interaction During the past few decades, our laboratory has been carrying out extensive molecular and functional studies on the cytokinetic protein, FtsZ, of different mycobacterial species, and of a variety of other mycobacterial proteins that are believed to be interacting with the cell division machinery. In this regard, in parallel to the work on MtuFic, we carried out work on the identification and characterisation of the proteins that interact with mycobacterial FtsZ. In this context, we found for the first time that the nucleoside diphosphate kinase (NDK), which can generate NTPs from ATP/GTP and NDPs, interacts with FtsZ and that the interaction was conserved across several mycobacterial species. Therefore, the FtsZ-NDK interaction was extensively characterised in vitro, using the recombinant, purified FtsZ and NDK proteins from different mycobacterial species. This novel finding on the interaction of NDK with FtsZ adds another role to NDK, namely in bacterial cell division. 2016-04-28T18:30:00Z


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Yaretsky v. Blum
Bibliographic Citation
Federal Reporter, 2nd Series, 1980; 629: 817-825
Permanent Linkhttp://hdl.handle.net/10822/787790
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Copley Hall at Georgetown University, as viewed from the east A.S. Blum Laboratories (Washington, D.C.) (1931)
The Impact of a Parental Notification Law on Adolescent Abortion Decision-Making Blum, Robert W.; Resnick, Michael D.; Stark, Trisha A. (1987-05)In 1984, we investigated the impact of a parental notification statute with judicial bypass procedures in Minnesota. Subjects were interviewed on the day of their abortion at four Minnesota and two Wisconsin clinics. ...


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Loma Linda Springs
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Verneater September 30, 2016
I visited this facility
Loma Linda Springs was very nice and very much affordable. There were a lot of units and was more of an independent living place. The grounds were well-kept, and the people were nice. Everybody there wasn't in need of help or somebody per se, and yet there were a couple of older people there who would very much appreciate amenities like the bus that takes you shopping and the game room. They have a mixture of age groups or people with different needs. The dining area was nice-looking.
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The people at Loma Linda Springs are the kindest people I've ever come in contact with. They always help you. It's a wonderful place. I'm very happy here. The men that works on the landscaping on the outside of the building does an excellent job. It's always beautiful. They're always working and they're appropriately friendly.
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Loma Linda Springs is a very good facility. The place is cheap and we already good an apartment. We're moving in about less than three weeks. The place is really kept clean. The maintenance crew is always out. The staff seems to be pretty good. I see them attending to the residents. They were nice to us.
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The Stages of Getting a Toddler to go to Bed [VIDEO]
Subscribe to Cat Country 107.3 on
I'm not a mom, but most of my friends have babies, so I know that this is true! Happy Mother's Day to all the Mom's out there!
And a shout out to the Dad's too!


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Bloodsucking at the Mall
If we told you something scary was happening in a mall parking lot at night, its understandable that you immediately jumped to the worst possible conclusion (i.e., a crime requiring the special victims unit). But cue a collective sigh, because its just an all-ages Halloween event, so the blood spatter and rotting corpses are probably not real. The largest haunted house in South Florida, House of Horror features actors doing their damnedest to evacuate your bladder, along with carnival rides, food designed to make you look like a cannibal, musical performances, and, hey, plenty of parking.
Sept. 29-Oct. 31, 6 p.m., 2011
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text: Why it's done By Mayo Clinic Staff Print A complete blood count is a common blood test that's done for a variety of reasons: To review your overall health. Your doctor may recommend a complete blood count as part of a routine medical examination to monitor your general health and to screen for a variety of disorders, such as anemia or leukemia. To diagnose a medical condition. Your doctor may suggest a complete blood count if you're experiencing weakness, fatigue, fever, inflammation, bruising or bleeding. A complete blood count may help diagnose the cause of these signs and symptoms. If your doctor suspects you have an infection, the test can also help confirm that diagnosis. To monitor a medical condition. If you've been diagnosed with a blood disorder that affects blood cell counts, your doctor may use complete blood counts to monitor your condition. To monitor medical treatment. A complete blood count may be used to monitor your health if you're taking medications that may affect blood cell counts. Request an Appointment at Mayo Clinic OverviewHow you prepare Oct. 18, 2016 Print Share on: FacebookTwitter References Complete blood count. Lab Tests Online. https://labtestsonline.org/understanding/analytes/cbc/tab/test. Accessed Aug. 29, 2016. CBC with differential, blood. Mayo Medical Laboratories. http://www.mayomedicallaboratories.com/test-catalog/Clinical+and+Interpretive/9109. Accessed Aug. 29, 2016. Understanding blood counts. Leukemia and Lymphoma Society. http://www.lls.org/managingyourcancer/labandimagingtests/understandingbloodcounts. Accessed Aug. 29, 2016. RelatedBlood BasicsAtypical depressionMultiple myelomaCyclothymia (cyclothymic disorder)TonsillitisTetralogy of FallotCancerHairy cell leukemiaGilbert's syndromeHigh blood pressure in childrenEssential thrombocythemiaIllness anxiety disorderThrombocytosisMyelodysplastic syndromesHeart diseaseMicrocephalyLupus Complete blood count (CBC)OverviewProcedure detailsWhy it's doneHow you prepareWhat you can expectResultsMore aboutIn-DepthMultimediaNews from Mayo Clinic Advertisement Mayo Clinic does not endorse companies or products. Advertising revenue supports our not-for-profit mission. Advertising & Sponsorship Policy Opportunities Ad Choices Mayo Clinic Store Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. The Mayo Clinic Diet BookMedical News From a Trusted SourceMayo Clinic on Healthy AgingA New Perspective on Alzheimer'sThe Mayo Clinic Diet Online Procedure detailsRequest an Appointment PRC-20212621 Patient Care & Health Information Tests & Procedures Complete blood count (CBC)


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Bruce - Jordan deserves call
Sunderland manager Steve Bruce has welcomed talk of Jordan Henderson becoming a full England international.
Last Updated: 15/10/10 5:08pm
Sunderland manager Steve Bruce has welcomed talk of Jordan Henderson becoming a full England international.
Bruce insists he knew he had a star in the making when he saw the 20-year-old in training after arriving at the club as boss last summer.
Fifteen months on, Henderson is being mooted to be included in Fabio Capello's squad for next month's friendly against France after impressing for the Wearsiders and for the Young Lions in the Under-21s set-up.
And the Black Cats chief has been stunned by the rapid progress made by the midfielder.
Asked if he could ever have imagined that call would come so soon for a player who had spent the last five months of the previous season on loan at Coventry, Bruce said: "You would have to say honestly, no.
"But I have to tell you, when I walked through the door, more than any other player, he grabbed me - and he grabbed me within two training sessions. I asked, 'Who's that?'.
"To be fair, I had more conversations when I first got the job about Jordan than any other player. He must have done exceedingly well at Coventry, which we know he did.
"We had half the Championship wanting to take him on loan again, so I had heard a little bit about him.
"I had seen him and been recommended him once by my chief scout saying Sunderland had a hell of a player when he was at Coventry.
"But he grabbed me straight away in the first couple of training sessions and hasn't looked back. He has done fantastically well."
Henderson has forced his way into the international reckoning at Under-21 level, where he scored in the play-off victory over Romania last week to help ease his country into next summer's European Championship finals.
He has since found himself at the centre of speculation that the likes of he and Jack Wilshere could step up to senior level next month, and Bruce would not be surprised if that proved to be the case.
He said: "The London press seem to have got their teeth into something and usually that means they have got a little whisper from somewhere.
"It wouldn't surprise me. Jordan's performance for the Under-21s on Friday night was fantastic.
"We have watched him and seen him develop over the last 15 months and he is going to be a wonderful midfield player.
"It wouldn't surprise me if he was in the squad because he is a very, very talented young player.
"There are not many playing week in, week out in the Premier League like he is, and starring in it.
"He is a kid who, if he can keep his feet on the ground and keep learning, which I am sure he will do, he has got the world at his feet."
In the meantime, Henderson will turn out for his club at Blackburn on Monday evening when he will once again link up with a rejuvenated Steed Malbranque.
The 30-year-old Frenchman has excelled this season since being moved from the wing into a free role behind lone striker Darren Bent, and Bruce has been delighted with his contribution.
He said: "Mentally, he has tuned in to what we want to do and he has worked extremely hard.
"It all boils down to Steed, really. I am not one for blowing my own trumpet and saying, 'We have done this'. Steed himself has done it.
"The thing we need from Steed is, I don't think he has scored in two years, and that's what we need at the moment.
"It's okay playing the system we are playing, but we need then to start chipping in a few goals from [Lee] Cattermole and Henderson and Malbranque and [Danny] Welbeck and [Ahmed] Elmohamady.
"They are all capable of scoring, so we need that to happen."


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Ask a Lawyer and Get Answers to Your Legal Questions
Hi - my name is XXXXX XXXXX I'm a litigation attorney here to assist you.
Yes, you can sue for breach of contract and you can prove that you loaned the money and that your friend paid you some back.
The biggest problem is that oral contracts are not valid unless they're fully completed within 12 months from inception. Thus, it is possible for your friend to claim that because the loan was not reduced to writing, it is not valid, and therefore, not collectible.
However, if your friend admits to borrowing the money and admits that the money is owed, you should be entitled to get a judgment against your friend for the money due.


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First of all, happy new year! Hope you all had a nice time spending the month with families and friends. If you've been editing the wiki over the holidays, I have only one thing to say, "it's the holidays! what's wrong with you!". :P
Back to talking about updates, the wiki has a new (and simpler) background image of Isaac clutching his head, being demented and paranoid. The previous background was colourful and action-packed but loaded slower than the current image, even after compressing the file quality/size. Hope you can forgive me for changing the background; sometimes, sacrifices are needed to make sure the wiki performs smoothly.
Some might have noticed that there has been small change made to the WikiActivity button located on the upper right corner. Yup, it was previously a WikiActivity button and currently a RecentChanges button. Allow me to explain what those two are: both WikiActivity and RecentChanges are site-overview features that allows users to see the ongoing activities on the site (obvious title is obvious; redundant). Whereas RecentChanges display all the activities in great detail, WikiActivity functions similarly albeit in less detail but with a more elegant user interface (i.e. those Most Edited articles and Community-corner). Which one do you prefer most?
Lastly, it's simply unfair for us PC users not having access to the demo.... RAEGQUIT!
As always, happy editing and buy Dead Space 2 on January 25th!


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When Mohammad Saber and Mohammad Asif started Zarnegar, a printing press in Mazari Sharif, it was boom time in the capital of northern Afghanistan's Balkh province. It was 1999 and Mazari Sharif was rapidly becoming one of Afghanistan's more important economic hubs. Posters and billboards dotted the city, proof of a flourishing advertising industry.
When Sania and Manizha Wafeq noticed that women in Kabul were becoming more fashion conscious and that they had more disposable income, the sisters set up a clothes company to cater to the trend.
Until recently, Afghan farmers in Zhari and Panjwayi districts in southern Kandahar province had been using local methods for leveling, plowing, irrigating and spreading seeds. They used animals to prepare their land for cultivation and spent days preparing a small piece of land for farming.
Until recently, Arghistan—a district in the southern Afghan state of Kandahar that borders Pakistan—imported most of its vegetables from Pakistan and grew poppy instead. It was the only crop that would flourish without water or modern farming techniques, there being no water in Arghistan's irrigation canals
In Afghanistan, a proliferation of mobile phones is dramatically changing how citizens across the country are communicating with one another. But for deaf Afghans, mobile phone usage is limited to SMS text messages—a particular challenge considering that less than one-third of the population is literate.
Last updated: October 24, 2016


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Community Members Raise More Than $425,000 for MemorialCare Heart & Vascular Institute at Long Beach Memorial
On Saturday, Feb.
Jump to navigation
On Saturday, Feb.
More than 300 community members showed their support for the Women Guiding Women: Cancer Support & Education Program, part of the MemorialCare Todd Cancer Institute at Long Beach Memorial, at t
Not sure where to go for help, Kristina Shafton and daughter, 7-year-old Maya, got on the 405 freeway and headed north.
Out of boredom while hospitalized during his first relapse, Jack turned to the Cooking Channel.
Art Klimeck is a retired physicist from Hughes Aircraft. His reason for giving back? "I'm just following the golden rule. You know, giving to others . . ."


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What is the main criticism of Dr. Weil? I remember him from 10 years ago. Figured he was dead or retired. He was always an advocate of Pollan's mindset: Limit carbs, moderate portions, eat veggies. What's wrong with that? You need him to eat ONLY meat and lard for years like a Paleo/Atkins extremist?
No announcement yet.
What is the main criticism of Dr. Weil?
new posts
What is the main criticism of Dr. Weil?Tags: None
This is what I posted on the other thread:
Mostly I am just glad to see some of the more popular Drs coming onboard, thus my reason for initially posting. Just that some are coming out and saying that what we thought we knew, might not be the way it actually is. Which leads way to realizing that maybe other things arent as we thought also. So I am very glad to see that.
Dr. Weil is still onboard with grains as well as some other things. Here is his pyramid. Dr. Weil's Anti-Inflammatory Food Pyramid
I also wasnt so sure about taking his advice to heart because he seemed a little tubby to me, like Santa Claus. But I love Santa and Santa is pretty darn old, as is the good doctor (well not THAT old but older than I thought) so he must be doing something right65lbs gone and counting!!
Fat 2 Fit - One Woman's Journey
That food pyramid shows you he is a high carb eater. He also woofs down soy and canola oil, both are less than optimal to ingest IMO. Oh but he does allow lean meat once a week. He is still a vegetarian at heart in my opinion trying to make his way to some animal flesh. He is very far removed from the diet Mark Sisson recommends.
What really puts me off about him is he has been and still is associated with PCRM. He is on the advisory board of the Vegan Avengers. Or as Anthony Bourdain calls vegans: The Hezbollah of vegetarianism. The morons are associated with the PETA retards.Last edited by Moochy; 08-23-2012, 09:42 AM.Primal/Paleo is not for everyone, it's for those who have committed to understand.
READ THE BOOK! ...as Robb Wolf says: "Trying to convince people to save their own ass will burn you out."
Vegetarians are the enemy of everything good and decent in the human spirit, and an affront to all I stand for -- the pure enjoyment of food.� Anthony Bourdain
and yes, calories DO count my little piggies
I have heard other health gurus refer to him in private as "fat andy". I have to agree that he really does not look all that fit & healthy, so I take what he says with a lot of skepticism. It might be all those grains he eats!
Originally posted by Moochy View PostThat food pyramid shows you he is a high carb eater. He also woofs down soy and canola oil, both are less than optimal to ingest IMO. Oh but he does allow lean meat once a week.
I mean you say "IMO" but that's actually not just your opinion. Kaayla Daniel has some hundreds of references on the problems connected with consuming industrial soy products -- like the soy "milk" he's got on the chart there.
I'll let him off limiting the consumption of meat -- although what's he's there thinking I don't know -- since he is recommending regular consumption of fish. But then if you must cut back on meat, why limit eggs and dairy?
I think that pyramid is still driven by the low-fat fear originally engendered by Ancel Keys, and this is why meat, eggs, and dairy are objects of suspicion to the man. But frankly that's a incompetent view in 2012.
Interestingly, it seems even Keys didn't eat that way himself. One of Sean Croxton's guests had a interesting anecdote of an elderly biologist he knows eating dinner in a restaurant with Keys. So Keys ordered a large steak, and the man said isn't that high in saturated fat. Apparently, Keys smiled a supercilious smile and said, "That's for the little people; that's not for me."
Sean Croxton, on being told this, just went "What???!!!??? .... he said that?"
Originally posted by OnlyBodyWeight View PostWhat is the main criticism of Dr. Weil? I remember him from 10 years ago. Figured he was dead or retired. He was always an advocate of Pollan's mindset: Limit carbs, moderate portions, eat veggies. What's wrong with that? You need him to eat ONLY meat and lard for years like a Paleo/Atkins extremist?
I don't really see that much criticism of him at all. Besides the trolls in the youtube comments you mock his weight.
I think he gives fantastic general advice and has proven he isn't above changing his views on certain issues.
Not a fan of "Fat Andy" until this he admited he was wrong on sat fat and supports Gary Taubes. You can see it if you youtube - gary taubes/larry king.
Also, in recent thread here on "Lard" , he actually promotes it.
It takes a lot of guts to admit you are wrong and then advocate something that was quite opposite of what you use to believe in.
For this, I highly respect him.
Here's the article on Lard in Dr. W newsletter Lard Making a Comeback - Dr. Weil's Daily Tip
Pretty bold of him. Got to admire him for changing his old ways.


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A Day Off
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Bedrooms: 3. Bathrooms: 2
Enjoy the privacy of staying in this private beach home only 1 1/2 blocks to the ocean. This 3 bedroom, 2 bathroom home features a large kitchen, living & dining area, and an oversized deck, perfect for family gatherings. There are 2 TV's in the house and a washer and a dryer. There is also a grill you are welcome to use. This home has been nicely decorated with a professional touch.
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- Jan 1 - April 25............$700/wk
- April 26 - May 30..........$800/wk
- May 31 - June 13..........$1,000/wk
- June 14 - Aug 1...........$1,250/wk
- Aug 2 - Aug 15...........$1,000/wk.
- Aug 16 - Aug 29...........$800/wk.
- Aug 30 - Sept 26...........$710/wk.
- Sept 27 - Dec 31...........$700/wk.
- Saturday-Saturday Only in the Summer.
- 3 night minimum off-season.
AmenitiesCable TV , Central Heat , Central Air , Grill
3 Bedrooms, 2 Bathrooms, Capacity: 8
Beds: 1 Queen, 1 Double, 2 Twins, 1 Sleeper Sofa
Minimum Stay: 3 Nights Off Season
Further Information
$25 Reservation Fee + 12% Tax
Restrictions: - Must be 25 or older to rent
Nearby Attractions: - Water Parks, Amusement Parks, Dinner Shows, Shopping, Shell Searching, Swimming, Sun Bathing, Hundreds of Restaurants, Jet-Skiing, Parasailing, Helicopter Rides, Fishing, and so much more...
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Vacation Insurance
We offer our users trip insurance policies designed for travelers going on a single trip. They can be used for flights, house rentals and a world of other trip types. We provide access to all the leading travel insurance companies to satisfy your trip insurance needs. Please consider using this insurance on trips to other countries.
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text:
Not Hunt Group, Actual Call to Queue Broadcast Agent Phones?
Unanswered Question
User Badges:
- Call comes in.
- Caller hears prompt asking if they are calling for Content Team Manager or Tech Support Manager
- Caller pushes option for either Content Management or Tech Support Management
- All manager phones ring at the same time and phones display the option the caller selected (either Content Mgmt or Tech Support Mgmt)
- The phones ring a max of 6 times
- If the call is not answered, call is delivered to a prompt thanking the person for their call, stating no one is available, to please contact a manager at their direct line for assistance.
- Release call.
Ideas? Would we use the 'Resource Pool Selection Model: Resource Group" under CRS/RmCm/Contact Service Queue?
I have this problem too.
0 votes


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Lynn Sweet
Listed by Home Sweet Home Realty
Drive way is in ! Its time to build the house!, We did the first step for you, now you just need to bring your builder and break ground! Building site sits off the road nice and private!! overlooking a "pond" area and seasonal views of Parker Mt. Stone Walls, tons of wildlife, easy access to all major routes and locations. Close to Town Hall, post office, library, school, Fire & Police. Lot also can support a duplex. Plan is approved and recorded at the registry "broker interest"
Date Showings Begin:
Delayed Showing: Unknown


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Celebrities Honor Jack Klugman and Charles Durning on Twitter
This Christmas Eve, the world bade farewell to two icons of show business — a pair of time-tested actors whose onscreen presence has maintained its vigorous influence since the early days of their careers. Jack Klugman, an actor nearly synonymous with his The Odd Couple character Oscar Madison, passed away at the age of 90. Charles Durning, a venerable chameleon with roles in everything from Dog Day Afternoon to Tootsie to Family Guy, died at the age of 89. Each performer has contributed something invaluable to Hollywood, with Klugman earning the honor of having perfected the art of the onscreen everyman, and Durning winning the superlative of the industry's champion character actor. Both men were and will forever be widely appreciated by fans and colleagues alike.
Since the passing of Klugman and Durning, many celebrities and artists have taken to Twitter to express their grief and reverence for the work of the actors. Below are a selection of tweets from fellow comedians and dramatists, all hoping to pay tribute to Klugman and Durning:
Jack Klugman
"@mikedrucker: RIP Jack Klugman, you were in everything I love and made everything I love better." I agree! So funny! So likable! The best.
— Judd Apatow (@JuddApatow) December 25, 2012
Condolences go out to the family of Jack Klugman. An extraordinary and talented man. He will be missed.
— William Shatner (@WilliamShatner) December 24, 2012
today i lost my mentor, second father and my dear friend.i will miss you so much jack and will be eternally grateful.RIP JACK KLUGMAN
— John Stamos (@JohnStamos) December 25, 2012
RIP Jack Klugman. You made my whole family laugh together.
— Jon Favreau (@Jon_Favreau) December 24, 2012
Have to give some appreciation for Jack Klugman, who was a great comedian. But also i appreciated him because i am an Oscar, not a Felix.
— Rachel Dratch (@TheRealDratch) December 26, 2012
I worked with Jack Klugman several years ago. He was a wonderful man and supremely talented actor.He will be missedbit.ly/Y8XfbP
— max greenfield (@iamgreenfield) December 24, 2012
Jack Klugman: a fine actor who didn't let throat surgery stop him from doing what he loved most–acting. Rest in peace
— Leonard Maltin (@leonardmaltin) December 25, 2012
Thank you for the laughs, Jack Klugman. RIP.
— Steve Levitan (@SteveLevitan) December 24, 2012
R.I.P. Jack Klugman . Epitome of the everyman. #Classact
— David Boreanaz (@David_Boreanaz) December 24, 2012
Charles Durning
RIP Charles Durning.Amazing obit in the NYT.Was in the first wave of troops to land on D-Day nytimes.com/2012/12/26/mov…
— Seth Meyers (@sethmeyers21) December 25, 2012
R I P CHARLES DURNINGthe actor's actor
— Henry Winkler (@hwinkler4real) December 25, 2012
RT @coltfan7: First Phyllis Diller, now RIP Charles Durning. Sad day for the #FamilyGuy company // Peter Griffin misses his mom & dad.
— Seth MacFarlane (@SethMacFarlane) December 25, 2012
Charles Durning, RIP: "I was born a character actor." dld.bz/bVeYU
— Roger Ebert (@ebertchicago) December 25, 2012
Sad. Love him in #Tootsie 🙁 RT @usweekly: Charles Durning, character actor, dies at 89 usm.ag/TmXosh
— yvette nicole brown (@yvettenbrown) December 25, 2012
Adios, Charles Durning. You were always 'that guy'. The best. RIP
— marc maron (@marcmaron) December 25, 2012
R.I.P., Great American. | "Actor, World War Two hero Charles Durning dies at 89." – news.yahoo.com/character-acto…
— Adam Baldwin (@adamsbaldwin) December 25, 2012[Photo Credit: Wenn (2)]
Prince William Airlifts Sick Baby to Safety
The Rolling Stones' Ronnie Wood Is Married
Claire Danes and Hugh Dancy Have Baby Boy


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Boyd Gaming appoints Chris Gibase to new position
July 28, 2014 7:11 PM
by Ray Poirier
Boyd Gaming Corp. (BYD) has appointed Chris Gibase to its newly-created position of senior vice president and chief marketing officer. He joined the company in 2002.
Also, two other appointments were announced: Steve Schutte and Vince Schwartz were named senior vice presidents, operations.
Ray Poirier is the longtime executive editor at GamingToday.
Contact Ray at email@example.com.
GamingToday on Facebook and GamingToday on Twitter


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Belmond was a colonel of French Intelligence who was worked in Paris during World War I.
In 1917, Colonel Belmond met with princes Sixtus and Xavier of Bourbon-Parma and supplied Indiana Jones with a mission into Austria whose government was secretly looking towards achieving a separate peace with Allied forces.
At the railway station, Belmond and his aide-de-cap Major Delon informed Jones and the princes that they would be contacted en route by an operative named Schultz.
Behind the scenesEdit
Belmond was played by Jeffry Wickham in The Young Indiana Jones Chronicles episode "Austria, March 1917".


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Product code: 27280
Despatched in 3-5 days.
Bvlgari Goldea EDP Gift Set is a manifesto of the BVLGARI style, a sumptuous floral-oriental Eau de Parfum with a luminous style that transforms sunlight into essence.For a woman of light and gold, a regal, sensual woman whose seductive powers reflect something of the divine.Goldea in its signature parfum bottle is featured in this luxurious gift set along with a deluxe purse spray plus an elegant mirror.Gift Set includes:- Eau De Parfum 50ml- Eau De Parfum 15ml.
Sign up for the latest news, offers and ideas.
eChemist.co.uk © 2017. All rights reserved.


text:
You won't be able to dismiss this by usual means (escape or click button), but you can close it programatically based on user choices or actions.
The iconic blue box and famous jewelry store can be the beginnings of a great wedding theme. This style of wedding can be especially stunning during the winter season because of its combination of icy blue and sparkling white. The Breakfast at Tiffany's wedding design can also be enhanced with elements from the movie of the same name. Evoke your inner Audrey Hepburn with some of her signature style and grace. Your wedding paper suite should include some of the signature blue colored invitations and premium thank you cards for a classic look.
The key to a successful tiffany blue wedding look is to place pops of the blue shade throughout your wedding elements. Brides can have their something blue with tiffany blue shoes or jewelry inspired by the famous store. Your white dress can be the perfect backdrop to a stunning bouquet of white and turquoise blue flowers, such as hydrangea or blue orchids. Don't forget to add some extra sparkle with shimmery bouquet pins. The teal blue color is one of the favorite shades that bridesmaids love to wear, ensuring that they feel comfortable in their dresses. Adorn your bridesmaids with strings of pearls to capture this classic style and look.
After incorporating the details of the color of tiffany blue, you can additionally make your event great by tying it back to its Manhattan origins. Wedding venues like downtown hotels or art galleries are perfect choices for this theme. Classy entertainment like a live swing band or a string quartet can instantly make your celebration more upscale. Featuring classic drinks like martinis and Manhattans can add to your atmosphere. Your favors can help your guests continue the tiffany blue affair with blue favor tags attached to a replica jewelry box. Sweets such as chocolates or mints may make a great parting gift to your guests.


text: fun indeed Adjust content blocking cavemanlittle Channel: fucking-tumblr next random Comment Top NextComment justice waits for no one next Tags: death | murder | SLAIN | Hell | martyr | flesh | burn | Hellfire | sickness Fun Fact: The average [serene wantd walk past a murderer want 36 three in their . I We haw this 'is mime a 'tim' fact. It' s fun because they didn' t decide he murder yea. ... +1292 Views: 54913 Submitted: 09/19/2013 Facebook Twitter Google+ Tumblr Pinterest


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Leather Punks OrgyFavorites [+]
Pay-Per-Minute Viewing
You can now enjoy this movie on your iPhone®, iPad®, or compatible Smart TV & Android devices.
Purchase Options
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Streaming Rentals
Running Time: 70 minutes
Released: 02/2006
Studio Name: Dark Alley Media
Director: Matthias Von Fistenberg
Description: Non-stop no holds bar orgy with 9 hung studs. This follow up to the critically acclaimed "Unleashed" proves no one can shoot an orgy as good as Dark Alley. Shot with 4-cameras, the fast paced unscripted action follows these guys as they fuck and suck each others brains out with abandon.
2 Scenes from Leather Punks Orgy
Leather Punks Orgy: Scene 1 Free Preview
Sex Acts: Anal Sex, Masturbation, Rim Job, Ass To Mouth, Oral Sex, Orgy, Domination, Fetish, Nipple Play
Positions: Cowgirl, Reverse Cowgirl, Suspended/Inverted, Missionary, Doggy Style, Sitting, Side Saddle, Laying, Standing
Settings: Dungeon
Studio: Dark Alley Media
Leather Punks Orgy: Scene 2 Free Preview
Starring: Matthias Von Fistenberg Owen Hawk ... More Details
Stars: Matthias Von Fistenberg, Owen Hawk
Sex Acts: Anal Sex, Toy Play - Oral, Masturbation, Circle Jerk, Rim Job, Oral Sex, Toy Play - Anal, Fetish, Nipple Play, Double Penetration
Positions: Cowgirl, Reverse Cowgirl, Suspended/Inverted, Crouching/Squatting, Missionary, Doggy Style, Kneeling, Sitting, Side Saddle, Standing
Settings: Dungeon
Studio: Dark Alley Media
Recommended Movies
AEBN Cams


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25. Lifts on all Centro buses make it possible for passengers with disabilities to take public transit. (scroll to pages 6 and 7)
24. Closed caption glasses at Regal Cinemas allow deaf movie goers to enjoy watching movies in theaters.
23. Newly constructed buildings open to the public must be made accessible and the existing public spaces are required to be retrofitted for access where possible.
Continue reading "25 Reasons To Celebrate The 25th Anniversary of the Americans With Disabilities Act"


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Our Pretties
As a person I am goal-oriented, kindhearted, positive and communicative! As a friend I am respectful, reliable, sincere and always ready to give my supporting shoulder.As a partner I am faithful, honest, devoted and trustworthy! I am open for the whole world and especially for my beloved man! As a woman I am romantic, warm, caring, with big heart full of unspent Love.And as your person, as your friend, as your partner, as your woman I will make you extremely happy! Hope you are ready for it!
I am sporty and fond of Yoga, as it helps my body to be fit and my soul to be tender. I try to enjoy each my day to the fullest! I think nothing is boring, if done with right attitude! So, I am always smiling, when I do household or cook, because they are my hobbies. I really love to make comfort at home and grow houseplants! I am fond of nature and animals, but can enjoy a walk in the city as well! I like to learn something new and to meet new people. Traveling is my big dream, but I miss a special person to share its pleasures with. Will you join me?!
Need partner: 48 - 58 years old
I see you as an honest, sincere, open and kindhearted person. I see you as a man, who wants to be loved and to love back.I see you as a strong man, who will enjoy giving me a tender hug. I see you as a man, who likes to smile and with whom I could laugh at any life moment and create positive atmosphere at home and make our family hearth warm. I see you as a man, who knows how to appreciate his lady, who is ready to trust, to be respectful and understanding. I see you as a man, who is ready to care and to be cared of! I see you as adventurous man, who wants to make our dreams to come true together! I see you as a man I cannot just live without!


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I come from Taiwan And I want find the share house
I have a partner, i smoke outside, i dont drink or do drugs. im honest,relyable, im easy to get along with, easy going,helpful,im caring, an im a strong believer in karma an treating others how id want to be treated and fun.
I am clean and tidy. Able to cook and clean up after myself. Appreciative and tolerant of others. Non smoker, non drinker and enjoy keeping fit and eating health.


text: Currently you can set a user to be moderated or not, however there is no option to have them moderated in only select nodes. The problem is, with a large active classifieds such as ours, we would like to pre-moderate only in this one particular node and not the entire forum. So simple suggestion to add the option of "Follow message moderation rules" for specific usergroups on a per node basis.


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Really P'd off
Discussion in 'General Discussions and Advice' started by Alan, 17 Oct 2007.
Page 1 of 2
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See Store for Pricing.
The all natural Nature Ball is made of sisal and has a fun playtime bell inside. Small pets will nibble, nudge, toss and roll. Safe chew-n-fun all rolled into one! Toys encourage healthy playtime activity and help prevent cage boredome for rabbits and other small pets.


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Mobile Development
Mobile apps are revolutionizing how we think, learn, communicate and act every day. For that reason, mobile dev techniques are ever-changing. With new training daily from expert authors, Pluralsight ensures you can learn the latest in mobile dev, whether you're building for Android, iOS or Windows.
Newest Courses
Oct 13, 2016
4h 18m
Mar 17, 2017
1h 17m
Jul 23, 2013
6h 21m
Apr 24, 2017
2h 35m
Aug 28, 2014
4h 25m
Aug 29, 2016
4h 32m
Feb 13, 2014
1h 52m
Jun 22, 2016
3h 54m
Aug 25, 2014
3h 12m
Jan 17, 2017
3h 40m
Ionic has established itself as one of the most popular open source frameworks for building cross-platform mobile apps. In this course, Building Mobile Apps with Ionic 2, Angular 2, and TypeScript, you'll see how to quickly get up and running with Ionic 2, and you will build a complete app from...
Play by play is a series in which top technologists work through a problem in real time, unrehearsed and unscripted. In this course, Filip Ekberg and Lars Klint will guide you through the fundamental steps of creating a Xamarin project. Watch as Filip and Lars collaborate on a weather app and...
In this course you will learn about all the features of Windows Azure Mobile Services including data, custom APIs, identity, push notifications, and management. You will also learn how to use all the client SDKs on all of the supported platforms (Android, IOS, Windows 8, Windows Phone, and HTML.
Learn to write real-world mobile web apps that are functional and performant even when internet connectivity is spotty or absent. In this course, Creating Offline-first Mobile Apps with HTML5, you'll explore tools and techniques that are currently available for making websites and web apps...
Most of us build typical business web sites using ASP.NET Web Forms. We are now being asked to build these as mobile-aware web sites. Using Bootstrap is a great place to start and Web Forms can do all of this - without having to learn MVC. This course will teach you how to build business...
People spend more time than ever on their mobile phones using apps. Building great apps is big business. But, you want to build them right the first time. In this course, Building an MVVM-based Architecture for Xamarin Mobile Apps, you will learn how to create a reusable, enterprise-ready...
This course demonstrates how several technologies can be brought together to form the basis of a solution for real-world retail scenarios, including Windows Azure Mobile Services, Windows 8, Windows Phone 8, Windows Azure Websites, MVC, Entity Framework, jQuery and SignalR.
Want to learn how to build native apps easily with free tools? This course introduces web developers to NativeScript, an open source framework for building native iOS and Android apps. First, you'll see the initial installation of NativeScript and configuring the modern open source...
The Ionic Framework is a tremendous step forward for quickly building Cordova-based mobile apps. Built on top of AngularJS, developers are able to leverage all of their pre-existing AngularJS skills when working with the Ionic Framework, considered by many to be the "Bootstrap for mobile." In...
You can leverage the skills and tools you are already familiar with to build mobile applications with Visual Studio Tools for Apache Cordova. In this course, Building Mobile Apps with Visual Studio Tools for Apache Cordova, you will learn how to take your existing knowledge of HTML, CSS, and...


text: Caterpillars can die in the cocoon stage when certain insects pierce or chew through the cocoon in order to get to the pupa. Caterpillars are also vulnerable when entering and leaving the cocoon stage. Learn more about cocoon safety with information from an entomologist and insect specialist in this free video on cocoons.


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Mercedes-Benz has kindly let loose the price of the US-spec 2015 GLA-Class, telling Autoblog that the base 208-horsepower GLA250 in two-wheel drive form will go for $31,300 *not including a destination charge of $925. That makes for $32,225 in total to get one off the lot, a price predicted as early as last year and in our recent First Drive. The other two available models can push power to all four wheels, and after the destination fee is applied the GLA240 4Matic (pictured) will be $34,225 whi
- Photos
- Feb 17, 2014
2015 Mercedes-Benz GLA250 4Matic: First Drive
2015 Mercedes-Benz GLA priced from $31,300*
- Jonathon Ramsey
- Jul 28, 2014
Mario Bros. enlisted to sell Mercedes GLA in Japan with bizarre results
- Chris Bruce
- May 29, 2014
There is always something a little grotesque when traditionally animated characters are brought into the real world. For example, something about seeing Mickey walk around Disney World just doesn't look quite right, and Nintendo is proving the rule with its latest cross promotion involving Mario and the Mercedes-Benz GLA-Class.
2015 Mercedes-Benz GLA250 4Matic [w/video]
- Matt Davis
- Feb 19, 2014
We all knew that Mercedes-Benz couldn't afford to resist the small SUVover segment for much longer. After all, it seems to be the fastest-growing segment in the galaxy, and in particular, it's the premium niche of that class – led by the hugely successful Land Rover Evoque and BMW X1 – that is making these smaller vehicles more viable and attractive. Off we go, then, in this spanking-new 2015 GLA250 4Matic, Mercedes' take on this still somewhat amorphous genre.
- 2018 Honda Accord is sleeker, more efficient
- Mercedes X-Class pickup truck revealed
- Find and compare 2017 Models


text:
MSc RoboticsFind a programme
|Faculty of Engineering
|Awards available
|Programme length
One year full time;
two years part time
|Part-time study available
Part-time students must be available to attend teaching activities during the normal core hours, Monday to Friday.
|Open to international students
|Start date
|September 2017
Programme overview
The MSc in Robotics will provide you with the ability to understand, design and implement modern robotic systems. Robotics is increasingly prominent in a variety of sectors, from manufacturing and health to remote exploration of hostile environments such as space and the deep sea, and as autonomous and semi-autonomous systems that interact with people physically and socially.
This programme exposes you to a wide range of advanced engineering and computer science concepts, with the opportunity to carry out a practical robot project at the Bristol Robotics Laboratory, one of the UK's most comprehensive robotics innovation facilities and a leading centre of robotics research.
The programme is jointly awarded and jointly delivered by the University of Bristol and the University of the West of England, both based in Bristol, and therefore draws on the combined expertise, facilities and resources of the two universities. The Bristol Robotics Laboratory is a collaborative research partnership between the two universities with a vision to transform robotics by pioneering advances in autonomous robot systems that can behave intelligently with minimal human supervision.
Fees for 2017/18
Full-time fees
- £10,200
- Overseas
- £19,700
Part-time fees
- £5,100
Fees quoted are per annum and subject to annual increase.
Alumni scholarship
University of Bristol students and graduates can benefit from a ten per cent reduction in tuition fees for postgraduate study. Check your eligibility for an alumni scholarship.
Funding for 2017/18
Further information on funding for prospective UK, EU and international postgraduate students.
Programme structure
Your course will cover the following core subjects:
- Robotics systems
- Robotic fundamentals
- Intelligent adaptive systems
- Robotics research preparation
- Image processing and computer vision
- Technology and context of robotics and autonomous systems
- Bio-inspired artificial intelligence
Typically you will be able to select from the following optional subjects:
- Computational neuroscience
- Uncertainty modelling for intelligent systems
- Introduction to artificial intelligence
- Learning in autonomous systems
- Design verification
- Animation production
- Advanced DSP and FPGA implementation
- Statistical pattern recognition
- Control theory
- Advanced techniques in multidisciplinary design
- Advanced dynamics
- Virtual product development
- Biomechanics
- Sensory ecology
- Transport modelling
- Electromechanical systems integration
- Advanced control and dynamics
Please note that your choice of optional units will be dependent on your academic background, agreement with the programme director and timetable availability.
During your second semester, you will start working on a substantial piece of research work that will make up one third of the overall MSc. It is possible to work on this project at Bristol Robotics Laboratory or in conjunction with one of our many industrial partners. Within the Bristol Robotics Laboratory, there are a number of themes from which projects may be chosen, including:
- Aerial robots
- Assisted living
- Bioenergy and self-sustainable systems
- Biomimetics and neuro-robotics
- Medical robotics
- Nonlinear robotics
- Robot vision
- Safe human-robot interaction
- Self-reparing robotic systems
- Smart automation
- Soft robotics
- Swarm robotics
- Tactile robotics
- Unconventional computation in robots
- Verification and validation for safety in robots
Further information is available from the Faculty of Engineering.
NB: Teaching for this programme is delivered at both the University of Bristol and the University of the West of England campuses. Students attending the programme will be given free transport passes to travel between the two universities.
Find out more about the programme structure and units available for MSc Robotics
Entry requirements
An upper second-class honours degree in engineering, physics, mathematics or a related subject. Other disciplines will be considered on a case-by-case basis.
See international equivalent qualifications on the International Office website.
|Application method
|Online application form
|English language requirements
Profile E
Further information about English language requirements
|Admissions statement
|Read the programme admissions statement for important information on entry requirements, the application process and supporting documents required.
Robotics is a huge field spanning areas such as electronics, mechanics, software engineering, mathematics, physics, chemistry, psychology and biology. Career opportunities include: automotive industry, aerospace industry, advanced manufacturing, deep sea exploration, space exploration, food manufacture, pharmaceutical production and industrial quality control.
18 August 2017. Early application recommended; places may fill before our deadline.
International students
Find out more about becoming a student at Bristol, and the support we offer to international students.
REF 2014 results
Categories 11 and 15 apply. Please see full REF 2014 results for the University of Bristol.
Results are from the most recent UK-wide assessment of research quality, conducted by HEFCE. More about REF 2014 results.
Open days and visits
Find out more about opportunities to visit Bristol.
Get in touch
Postgraduate Admissions Phone: +44 (0) 117 954 5130 Email: firstname.lastname@example.com
MSc in Robotics
Postgraduate Admissions
Faculty of Engineering
University of Bristol
Queen's Building
University Walk
BS8 1TR, UK http://www.bristol.ac.uk/engineering/postgraduate/ http://www.bristol.ac.uk/engineering/departments/engineering-mathematics/
Important disclaimer information about our programmes.