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Miles for Miracles
New Balance Falmouth Road Race
Run with us on August 20, 2017
Apply to run America's Family race in its 45th year for the best pediatric hospital in the country. Looking for a waiver for New Balance Falmouth Road Race or already have a waiver from the race?
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Run with the Miles for Miracles team and raise funds for the hospital
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Our goal: $150,000.00
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- Access to team coaches
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Why Boston Children's?
Boston Children's Hospital ranks first in more specialties than any other pediatric hospital—expertise that allows us to solve medical problems in new ways.
The support of Miles for Miracles runners helps our doctors, nurses, and researchers continue to innovate patient care, find cures, and bring the extraordinary to life.
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Costs in Employment Tribunals
By Daniel Barnett, Samantha Cooper, Kate Palka
In the UK, while the civil courts ordinarily award costs to the successful party, it was previously rare for employment tribunals to do the same. Costs orders are now becoming more common in UK tribunal cases, where one party acted unreasonably or where the bringing or conduct of the case was misconceived. Employment lawyers must therefore be aware of how to obtain costs awards for clients, and how to avoid having one made against them, even if they are the winning party. This book analyzes what tribunals are doing and, more importantly, why they are doing so. Uniquely, it draws on decisions in approximately 100 unreported UK tribunal cases where costs were awarded or refused, offering the reader clarity on how costs decisions are made in these cases. This second edition has been completely revised in light of the Employment Tribunals (Constitution and Rules of Procedure) Regulations 2013. The key changes include: a) the power of the Tribunal Judge to conduct a detailed assessment of costs in excess of ?20,000, adopting the same principles as the County Court in doing so; b) a power entitling a party to have their tribunal fee paid by another party; c) a specific power relating to the payment of the expenses of witnesses; and d) circumstances in which a tribunal may make a costs order or Preparation Time Order. [Subject: Employment Law]
Publication Date: 10/29/2014
Format: Cloth

subset: commoncrawl


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|"Uwe Schindler (JIRA)" <j...@apache.org>
|[jira] Commented: (LUCENE-1590) Stored-only fields automatically enable norms and tf when added to document
|Wed, 08 Apr 2009 21:56:13 GMT
[ https://issues.apache.org/jira/browse/LUCENE-1590?page=com.atlassian.jira.plugin.system.issuetabpanels:comment-tabpanel&focusedCommentId=12697238#action_12697238 ] Uwe Schindler commented on LUCENE-1590: --------------------------------------- bq. Since FieldInfos is per-segment, one challenge is how Multi*Reader should work. Should it simply merge on-the-fly? (ie present a single FieldInfo that merged the fields by the same name across all segmens) Maybe merge with the already existing FieldInfos/FieldInfo methods. A new case for this would be good, after thinking a little bit about it, I may open one. But in general it should be combined with the Document/Fields redesign. bq. This sounds like a good stop-gap measure, but I'd rather put our energy towards exposing the schema, decoupling "retrieved" Fields from indexed fields, etc. Yes, and it will not work. I think, we leave the patch as it is, maybe remove the omitTf and omitNorms update for binary fields. Binary fields are "special". > Stored-only fields automatically enable norms and tf when added to document > --------------------------------------------------------------------------- > > Key: LUCENE-1590 > URL: https://issues.apache.org/jira/browse/LUCENE-1590 > Project: Lucene - Java > Issue Type: Bug > Components: Index > Affects Versions: 2.4, 2.4.1, 2.9 > Reporter: Uwe Schindler > Assignee: Michael McCandless > Fix For: 2.9 > > Attachments: LUCENE-1590.patch, LUCENE-1590.patch, LUCENE-1590.patch > > > During updating my internal components to the new TrieAPI, I have seen the following: > I index a lot of numeric fields with trie encoding omitting norms and term frequency. This works great. Luke shows that both is omitted. > As I sometimes also want to have the components of the field stored and want to use the same field name for it. So I add additionally the field again to the document, but stored only (as the Field c'tor using a TokenStream cannot additionally store the field). As it is stored only, I thought, that I can left out explicit setting of omitNorms and omitTermFreqAndPositions. After adding the stored-only-without-omits field, Luke shows all fields with norms enabled. I am not sure, if the norms/tf were really added to the index, but Luke shows a value for the norms and FieldInfo has it enabled. > In my opinion, this is not intuitive, o.a.l.document.Field should switch both omit* options on when storing fields only (and also disable other indexing-only options). Alternatively the internal FieldInfo.update(boolean isIndexed, boolean storeTermVector, boolean storePositionWithTermVector, boolean storeOffsetWithTermVector, boolean omitNorms, boolean storePayloads, boolean omitTermFreqAndPositions) should only change the omit* and other options, if the isIndexed parameter (not this.isIndexed) is also true, elsewhere leave it as it is. > In principle, when adding a stored-only field, any indexing-specific options should not be changed in FieldInfo. If the field was indexed with norms before, norms should stay enabled (but this would be the default as it is). -- This message is automatically generated by JIRA. - You can reply to this email to add a comment to the issue online. --------------------------------------------------------------------- To unsubscribe, e-mail: firstname.lastname@example.com For additional commands, e-mail: email@example.com
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See's Candies at Lord & Taylor in Freehold sells our American made candies and chocolates. The best chocolate and candy in Freehold, NJ can be found at See's Candies where we are famous for our deliciousness and friendly customer service.
The Lord & Taylor See's Candies location at 3710 Us Highway 9, Freehold, NJ is a partner store and therefore does not carry our full line and assortment of candies. It also does not accept promotions and gift cards that you may see promoted on our website or other advertising vehicles. However, this location does feature our timeless favorite candies such as boxed chocolates, peanut brittle, nuts and chews, and lollipops. Please call ahead of time to be sure we have your favorite candy at this particular Freehold See's Candies location.
Come on into your Freehold See's Candies at Lord & Taylor today! See's Candies has been around for 90+ years- and once you taste our candies and chocolates, you'll know why.


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Jonathan Castellanos is an American actor.
To be added
On Criminal MindsEdit
Castellanos portrayed Angel Suarez, a teenager abducted by J.B. Allen as a boy, in the Season Seven episode Foundation.
- The Mentalist (2013) as Oscar
- Go for Sisters (2013) as Kid
- Criminal Minds - Foundation (2012) TV episode - Angel Suarez
- Off the Map (2011) as Charlie (13 episodes)
- Southland (2010) as Lil' Casper (3 episodes)
- Rules of Engagement (2007) as Kid
- Boston Legal (2007) as Domingo Obisbo
- Side Order of Life (2007) as Mauricio Santillan
For an up-to-date filmography, see here.


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Rykhart's Residence is the personal residence of Wilhelm Rykhart.
In 1997, Roland Jackson and Eduardo Rivera visited the residence in an attempt to warn Rykhart about the theft of the Toltec Skulls. He showed them his steel titanium vault, where he kept his valuables in. Soon after, the three Spirit Slaves emerged from the vault and flew upstairs past the butler. Roland and Eduardo pursued but the ghosts flew out an open balcony door. Only a 300 year old Ming Vase was damaged.


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As we see the last of the balmy summer days, autumn starts our migration towards home and cosy evenings in. The transition from BBQ's and days spent in the park to evenings at home can be difficult, however, the Autumn Retreat trend is the perfect solution. This interior trend is led by the changing of seasons and our relationship with nature, dominated by tactile and warm materials, woodland prints and rustic elements.
The interiors stylist, journalist and author of Home for Now (CICO Books), Joanna Thornhill (www.joannathornhill.co.uk), shares her expertise on interior trends with Furniture Village. "Dark, inky blues continue to be a popular choice for AW15, offering a way to tap into the trend for dark interiors yet with a little more colour and interest then simply going for grey. When teamed with other berry tones, the look is cosy and sophisticated - perfect for the cooler months to come.
Joanna continues "copper is still huge yet is increasingly being mixed with other warm metals, from gold and brass to pewter, for a more rounded, eclectic look. And, summer florals are being replaced with more Eastern European, folk-art-style blooms, with their sister trend, botanicals, moving away from the kitschy Club Tropicana styles seen in high summer in favour of a more muted palette of greens and neutrals, allowing the natural pattern of the leaves to shine."
Elma Malik, Online Buyer at Furniture Village, gives her insight on upcoming trends this season:
While it is very tempting to install bi-fold doors to merge your garden with your home's interior, fortunately there are less drastic options for bringing nature indoors. Think a chunky, oversized wool throw across your bed, along with heavy cottons and rustic linens to engage the senses and bring homely comfort.
You can further work the trend with white, grey or black cushions, which will mirror the cooler shades of the skies outside. Alternatively, if you are a fan of patterns, geometrics in a muted hue or woodland motifs, like subtle plants and trees are very on trend for autumn and can add a real sense of relaxation and comfort to your home.
To really evoke the feeling of relaxed grandeur and casual comfort you can add a statement rug with rustic elements or speckles of colour.
If you want to take this cosy and comforting trend to the next level, think about a luscious, soft leather armchair to add some understated glamour to your living room. Alternatively, you can add an edge to your interior with wire frames to evoke an industrial feel and show the element off with a warm glow from a solid metallic lamp in a copper or any other metallic shade.
The browser you are using does not support our magic.
To continue browsing Furniture Village, please install the latest version of any of the browsers listed below.


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Voyeur : October 2009
CULTURE_ 043 OCTOBERVOYEUR MY FASHION MOMENT I now work in corporate finance at Deloitte and also campaign for the environment. I keep all of my jerseys from my whole career in a leather antique suitcase. Even though this jersey represents a sense of discontent that will probably last a lifetime, I prize it above any other, as to play in an AFL Grand Final with my team mates was an absolute honour. My children love looking in daddy's memories box. My five-year-old daughter, Charley, recently took this jersey to school for show-and-tell, while my three-year-old son, Tommy, dreams of playing for Collingwood at the MCG. Maybe he'll be the one to win the premiership." THE SIGNATURE BELT Sam Townsend, 26, is a student and drag ar tist, and he treasures his mum's 1980s black leather palm frond clasp belt so much that he works it into every outfit. "I have always loved dressing up. I lived in my Superman and Batman costumes when I was a little boy, and as I got older I started creating my own characters to dress up as. They were usually witches and wizards, which had been inspired by movies like Labyrinth and The Dark Crystal. It was the late 1980s and I'd raid my mum's wardrobe to find inspiration. Her exotic Japanese silk dressing gown could turn me into a wizard high priest, the scar ves in her wardrobe added a splash of colour, and her jewellery and shoes finished off the look. One of my mum's signature pieces w as a black leather belt, w hich she used to wear with her high leather boots. I remember thinking how glamorous she looked when she wore it. I was fascinated by the belt's elaborate buckle, and I felt like it could make any of my own costumes really come to life. I left dressing up behind with childhood until I started at art school in Canberra. There was a costume party ever y weekend and we'd all tr y and outdo each other. It was not long after my 21st birthday that I started per forming in drag. For my first performance, I had to put my outfit together and found myself raiding my mum's wardrobe at the last minute. A s soon as I saw the belt hanging up in there, I knew it would bring my outfit together – just like it had done when I was child. The belt has since become part of my drag bag. My I was fascinated by the belt's elaborate buckle, and felt like it could make my costumes come to life. If you've got it, flaunt it: Sam Townsend belts out 1980s' favouries at parties and clubs. V1009_040_044_CULTURE.indd 043 V1009_040_044_CULTURE.indd 043 9/09/2009 3:37:38 PM 9/09/2009 3:37:38 PM
September 2009
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text: May 2014 Auto Sales: Winners and Losers Share Tweet Subscribe Get AutoGuide.com in your Inbox Like AutoGuide.com on Facebook 2 of 10 By Luke Vandezande Jun 03, 2014 Winner - Audi +26 Percent Audi's A6 sedan helped boost the brand to a respectable 26 percent increase last month, but it wasn't the only vehicle with noteworthy contributions. The A3 is also proving to be an early hit as the third-most popular nameplate in Audi's lineup. 2 of 10 Previous Next Filed under: Featured Articles Sales Tags: Audi, Auto sales, Bentley, Chrysler, Infiniti, Jeep, Maserati, may auto sales, MINI, Sales Winners and Losers, tesla, Volkswagen, Volvo, vw, winners and losers


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Robert Alvarado Photographer
Acidalia RebeliModel Female Colorado Springs, Colorado, US
My Website: Suicide GirlsMy MM URL: http://www.modelmayhem.com/mollymhogan
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I am a fun, relaxed yet energetic girl.. looking to make magic happen and create beautiful works of art!
My genres include:
• Fashion/Glamour/Bikini
• Playboy Style Nudes
• Implied (Maxim style)
• Artistic Nude & Tasteful Erotica
• Secluded Outdoor Shoots
Modeling is my passion.. not just a hobby!
Please note that I am strictly a professional, and take pride in the art we set forth to create. Please DO NOT contact me if you cannot respect this. Serious inquiries only.
I will do TFP/tests on a VERY limited basis for published photographers at my discretion. Don't be afraid to ask.
Please contact me for more details and rates. I am willing to travel if expenses are paid.
Thanks so much for your consideration!
♥Acidalia Rebeli♥
Have you worked with Acidalia Rebeli? Add Credits for Acidalia Rebeli! >>
"on time, very professional and a pleasure to work with."
See Sample Worked together 1 times; Most recent: August 2015
"Thank you Molly for a wonderful shoot. I very much appreciate your planning and efforts to make sure the shoot was highly successful. I look forward to our next shoot."
Worked together 1 times; Most recent: December 2015
Credit Notes
ID#1538447 ellipsis PHOTOGRAPHIQUE
ID#15033 Robert Alvarado
ID#3005 nevar
Robert Alvarado Photographer
nevar Photographer
Mary Jane Burthe Model
Voltaire Photographer
craig ratcliffe Photographer
Mikey Forster Photographer
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The National Entertainment Collectibles Association (or NECA) is an American manufacturer of collectibles typically licensed from films, sports, music and television, based out of New Jersey. The company was founded in 1997 and has over 60 licenses for which it produces diverse memorabilia.
The company is planning on creating a series of action figures based on characters from Castlevania: The Movie.
In 2002, NECA's Reel Toys was formed as a division to produce action figures and dolls that are targeted toward action figure and toy enthusiasts. They are intended for teens and adults as collectibles for many licenses that no other company would really try to market as a toy.
NECA is best known for obtaining licenses such as The Silence of the Lambs and V for Vendetta.
External LinksEdit
|This page uses content from the English Wikipedia. The original content was at National Entertainment Collectibles Association. The list of authors can be seen in the page history. As with the Castlevania Wiki, the content of Wikipedia is available under the Creative Commons License.


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Stayed here for a recent fishing trip. The room was very clean and the grounds well maintained. Upon arriving I was concerned about possible noise as there were no vacancies in the hotel. During my two night stay it was very quiet and I heard neither other guest or road noise. I would give the hotel high marks for providing a clean room at a reasonable price in a small town. The only downside was a sparse continental breakfast which was more like snacks than breakfast. It was comprised of energy bars, or a few pastries or instant oatmeal. A few bagels or hard boiled egges would have gone a long way to improving the breakfast. That aside if you are looking for clean room at a convenient location this would be a good choice.
- Official Description (provided by the hotel):
- Located in the beautiful Fall River Valley, the Hi-Mont Motel makes the perfect base for exploring all this unique area has to offer: hiking, fishing, hunting, golf, whatever. Our exceptionally clean, comfortable and spacious rooms feature coffee makers, fridges, microwaves and hair dryers, and pet friendly. Free Wi-Fi and premium satellite TV. Facilities include a fish cleaning station, horse shoe pit, BBQ picnic area and ice machine. ... more less


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Recently the University of Texas and University of California Los Angeles released the findings of a tantalizing little research study they collaborated on. By "little" I mean over 24,000 horny college students and by "tantalizing" the study on sexual regret. Interestingly, rather than reflecting the perceived permeation of the unshaven, un-showered, fuck-responsibility and social norms YOLO-culture, it exposed that most participants regret their sexual history…and that's just sad! For all the big talk and emo memes that millennial sites and Twitter junkies share, they do care what others think…A LOT! What it means to be a man, what it means to be a woman, how I size up, and how will you size me up. It sucks to think that the same judgmental ills that plagued my generation and those before has yet to be eradicated and are as contagious as ever.
- Going ''too fast'' or engaging in too much sexual activity with my (past or present) relationship partner: 43% {men26%}
- Losing my virginity to the wrong person 41% {men 18%}
- Engaging in a sexual activity with someone I did not find attractive 37% {close with men 40%}
- Engaging in a sexual activity with someone who led me to believe he/she was interested in a relationship but really just wanted to have sex 37% {men 15%}
- Engaging in a sexual activity with someone who I barely knew 36% {men 20%}
Men's Top 5 Sexual Regrets
- Not indicating my sexual attraction to a particular person because I was too shy or nervous 55% {women 30%}
- Not being more sexually adventurous when I was young 48% {women 18%}
- Not experimenting more sexually when I had the opportunity 47% {women 21%}
- Not being more sexually adventurous when I was single 42% {women 17%}
- Engaging in a sexual activity with someone I did not find attractive 40% {women 37%}
Sexual Regrets and Gender Gaps
- Not engaging in a sexual activity with an attractive person {Men 37% Women 9%}
- Not losing my virginity early enough {Men 26% Women 6%}
- Engaging in a sexual activity with someone because it made me feel promiscuous or ''dirty'' {Men 9% Women 33%}
Yeah…and some sexual regrets are universal!
- Men and women equally regretted cheating on a partner {as we all should} and engaging in sexual activity with someone who wasn't good-looking {been there, done that}.
Screwing the ex, being a side chick, bumping uglies with uglies, and walks of shame may be humbling side effects of drunken courage or hormonal surges but to count most of these sexual oops as regrettable is a sign of either a lack of experience or lack of knowledge gained from an experience. The study's discussion points wander into whether the feelings of regret are influenced by society's mores or evolutionary psychology; hot topic debated across forums and comment sections everywhere the study is cited. Where ever your opinion lies on the question of nature versus nurture, the study's commentary can be easily summed up by the gender variances of sexual regret by opportunities missed and opportunities taken. While men regret not being more aggressive in the pursuit of sexual experiences, women regret the ones they've had; leaving both genders feeling f*cked over.
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Review: "Sam is a thoroughly knowledgeable, diligent attorney who represented me superbly well as plaintiff in a civil action against my former employer . . . whose position may be summarized basically as "stonewall" . ...
Practice areas: Employment & Labor, Discrimination, Civil Rights, Constitutional
Employment attorneys focus on the many laws concerning the relationship between employers and employees. If you feel your employer has treated you wrongly as an employee, or if you're an employer who needs to terminate an unsatisfactory employee, you may benefit from the services of an employment attorney. Some professionals, such as teachers, policemen, and pilots, belong to labor unions, which have specific negotiation and labor law procedures that protect union members. A labor attorney will know which laws apply to your particular situation and how you can take advantage of the laws to protect your rights.
|Allison Park
|New Kensington
|Cranberry Township
|Lower Burrell
|West Mifflin
|Moon Township
|Beaver Falls
|Mckees Rocks


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This 6-storey hotel comprises a total of 58 rooms, which includes 7 suites. Facilities include an inviting foyer with a welcoming 24-hour reception desk, a safe, a currency exchange desk and a lift. Dining options include a pleasant caf� and an elegant lobby bar and there is also public Internet access as well as a WLAN access point to take advantage of. Room and laundry services are available and those arriving by car may make use of the public underground car park (fees apply).
This pleasant city hotel lies at the heart of Paris, within a short distance of the Arc de Triomphe and a stone's throw from the Champs Elys�es. The hotel provides an ideal point of departure for shopping and sightseeing tours of the city with the nearest links to the public transport network (Etoile metro station) lying a mere 10 m from the hotel. It is a short distance to an abundance of restaurants, bars and pubs and nightclubs are to be found about 1 km away. Paris Charles de Gaulle and Orly airports are both around 20 km away.
The elegant, Parisian-style rooms are all carpeted and come with a double bed, an en suite bathroom with a shower, a hairdryer, a direct dial telephone, satellite/ cable TV, a minibar and a hire safe. An Internet connection and individually controlled heating and air conditioning feature as standard.
An ample breakfast buffet featuring an array of French specialities is on offer every morning.
An ample breakfast buffet featuring an array of French specialities is on offer every morning.
Room Facilities:
Direct dial telephone
Satellite cable TV
Internet access
Double bed
Individual airconditioned
Individual heating


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Decorative gift box elegantly designed and excellent for shipping with approximately 34 pieces of fruit including oranges, red and yellow delicious apples, and pears plus fudge, pure maple syrup, jelly, and honey.
This item can be shipped anyware in the United States. If you want to ship this item outside of the local Erie area please call or fax your order. Phone 814-833-9933 - Fax 814-774-9807
Price $59.99 as pictured.


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Tea from China - Pu-Erh Pasha Small Tree
This superb tea, brilliantly manufactured in Yunnan by the producer Men San of Pasha Zhai has a rich aromatic profile: a fresh attack, camphor notes with a finish combining notesof apricot to a hint of waxed wood. By each tasting you will aprreciate a new facet of this surprising tea.
- Dominant note: Plain
- Type(s) of tea: Dark teas
Serving suggestion
Infusion 3/5 min
Temperature 80/90° C - 176/194°F
Moments Evening
VISA, Mastercard, CB, Paypal Secure payment
Customer service +33 2 37 65 60 00


text:
Gintama° (2015) Episode 43
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The impact of climate change on agriculture
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Studies that include moderate climate forecasts, farmer adaptation, carbon fertilization, and warm-loving crops tend to show that climate change will have only mild impacts on average global agricultural output and may even improve temperate agricultural production. On this point, recent studies yield strikingly consistent results. Of course, impact estimates still contain uncertainties. Key questions include how agriculture might change by 2060, how tropical and subtropical farming will be affected, and how effects will be distributed regionally. The most likely threat to agriculture from climate warming is regional damages in relatively poor areas that lack either the knowledge or the financial resources to adjust. Although it is not clear which regions will actually suffer, the ones that are most vulnerable lie predominantly in or near the tropics (IPCC, 1995). Nonetheless, on average, the factors discussed in this essay will help mitigate the impact of climate change on agriculture.
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by Noreen McDonough
(Bristol, VT)
Two weeks after Labor Day 2000, I brought Buddy home after answering an ad in the newspaper for a FREE DOG. Although the family rescued him from a shelter at 3 months old he was not a good match with their cat who he chased continuously. When I came for a visit, he was wiggly and wagging his tail and sat right down in my lap and gave me kisses.
Obtaining a dog marked the beginning of my new life a single mother. My two daughters loved him and treated him like a new brother. Their dad never wanted pets around.
There was a big adjustment period as Buddy was extremely energetic. I knew he was trainable because at six months, he could stay downstairs and off the furniture. However he was clever, too. Each morning as I descended the stairs I could hear a soft two-beat thump as Buddy carefully slid off the couch. I am not a good trainer and in no time, he had full run of the house and found a spot on the arm of the couch to look out the window like a cat. At 35 pounds, people outside took not and liked to see him there.
But his split second bounding whenever the door opened the slightest crack was something that quickly became troublesome. He was not fond of strangers. A mixed breed with a herding instinct, he would circle people that approached our door and try to nip from behind. There was a family a few doors down that were terrified of him which only provoked him more. And they called Animal Control many times when he had gotten loose. My boyfriend lived in rural Vermont and took him shortly after he turned three when tension in the neighborhood was high.
Within a year, I had sold that house and moved near my boyfriend and Buddy moved back with us. But he never out grew taking himself for walk when we weren't watching him closely.
On December 6, he was walking back from visiting his dog friend up the hill and was hit by a car. I am totally responsible. I had let him out while I vacuumed and was not watching. I allowed to wander. I put my dog in harms way. I also put Buddy in the way of the car and caused my neighbor who hit him with his truck much grief.
In 2000, when I made the decision to get a dog as a presence to ward off burglars or worse and a companion to me and my family, I could afford the vet and food expenses. Within seven years, my income would dwindle as my profession, an interior house painter and gardener, was one of the first to feel the recession.
I had a few bad experiences taking Buddy to the vet. The first happened when Buddy was bit by a neighbors husky. The husky had been terrorizing the neighborhood for over a year. I was VERY careful with Buddy and always had him a leash. This dog would seek dogs out on their own property and drag its owner across the street the get at dog when they were out walking. This attack occurred right as we were moving for two years so my daughter could attend an Arts Academy for her last two years of high school. I submitted the vet bill to my neighbor and it wasn't paid for a very long time. My name was put into collections.
The next time Buddy went for his rabies shot and well check about two years later, the vet asked for payment up front. I requested being billed as usual. They had taken Buddy into another room for the shot and told me I could have my dog back until the bill was paid. I ran home and got a check I knew would bounce but within the week I would have gotten paid and could pay the over draught and the bill in fill. It never occurred to me that this was illegal and they had no right to impound my dog. They were not clear at the beginning of the appointment.
I was disappointed another time at the vets. I had just paid $285 to get a full range of tests they offered for senior dogs. There was some signs of inflammation indicating he had the beginning of arthritis. i could purchase a months worth of Rimadyl for $75 or six months for $180. I make about $350/wk at the moment and was planning on visiting my 92-year-old mother for Thanksgiving. I wouldn't be able to do that I explained. I was a offered a free two week supply to see if it would make a difference.
And it did! Buddy began climbing the stairs to give me a "good morning" kiss. The woman in the business office said sometimes they will offer a payment plan. So I called after two weeks and asked if I could buy the economic size in the payment plan. I was refused for some reason.
So the day Buddy was hit by a car, I was a mess. I could not make phone calls from my rural address so I texted my elder daughter who lives in town and told her to call the animal hospital and tell them I was coming with Buddy who had a severe head wound. As I drove down the mountain with Buddy's head near by leg, I contemplated asking my daughters boyfriend to shoot him like they did in the old days. I had no money to pay for the vet. But I wanted to do the right thing for Buddy as he was a loyal and loving family member and he deserved a chance. I tried to remain positive.
As soon as I arrived at the animal hospital, I told the doctor I had no extra money but I could pay for an examination. She asked me a few questions about what happened and asked me to leave. That was the last time I saw Buddy alive.
My daughter arrived about twenty minutes later with her year old son. He had bonded with Buddy and went he would visit, insisted Buddy stay near. He was very attentive to him and in his innocent baby way, called him "Bubby!"
The doctor came out shortly after my daughter arrived. Buddy had a seizure but also tried to lift his head. She said the bill was at $200. She wanted to give Buddy a chance. She suggested keeping the fluids going and his pad heated for the overnight. She indicated there was an extra charge for that. After I agreed that would be best, she touched my arm and informed me I would need to leave a deposit...Could I do that?
The next fifteen minutes was spent getting the computer to the correct ap, writing a payment agreement that the bill would be paid in full within the month or interest charges would included, this and that. I wanted to see my dog after that and say good night. I explained that my grandson was very good friends with Buddy. Orion would love to see Buddy. They didn't think it a good idea as he was connected to a lot of tubes so I didn't but they didn't offer me to see him either. It almost time for the office to close and we left.
Twenty minutes later I was making my way up the mountain road and got a call from WITHHELD. I had to wait to get home to listen to the message in the special spot in the house were I get reception. The doctor informed me Buddy had died and I could pick him up in the morning. I turned around and determined to bring him home. The weather had been mild but it would freeze hard overnight. I could not afford to cremate him and would need to bury him right away.
I arrived at the hospital just in time. The doctor had left and the last two techs were locking up. I said I wanted to bring Buddy home and they were obliging. We went in, I collected the stained sleeping bag I had wrapped Buddy in and then received his body which had been placed in black plastic. Although he was taken from the freezer, his body was still warm.
There are times one wishes they could go back in time and make different choices so a loved one would still live. I have tried to me kind to myself and accept the kind words my friends and family offer...You gave him a good life...I did, yes...
He was so old....Yes, old and in the way...It was blessing death came quickly...Yes, think he was in shock and did not feel any pain.
But the truth is I am to blame for my Buddy's death. That's been difficult enough to live with. It's been a month. I have grieved. I have cried. I try to be present in the lives of the loved ones left behind.
But I also allowed money to be the focus of the few moments left of my dogs' life. I allowed them to take my dog. I left when they told me to leave the examination room not feeling comfortable leaving him with strangers. I never left him with strangers. Not even for an overnight. If I had to be away, he stayed with people who loved him, my ex-boyfriend, one of my daughters, or I figured out a way to take him or I did not go. I was not courageous enough to say, "I only have enough money to let Buddy go tonight. He will never regain use of his right eye and will most likely have severe brain damage if he lives. I am going to hold him in the a circle of love with my daughter and grandson and set him free. And we will be, too.
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text:
What ship blew up in Havana Harbor leading to the US declaring war on Spain?
USS Maine
USS Arizona
the Lusitania
Pearl Harbor
In what year was the Spanish American War fought?
Who was Cuba fighting against in the Spanish American War?
the US
the Philippines
What kind of journalism did publishers like Hearst use to get the US into the war?
Red Journalism
Yellow Journalism
How did the Spanish insult the US President, making the US made at Spain?
in an interview with Joseph Pulitzer
by blowing up a ship
in the de Lome letter
by refusing to trade with the US
Where was the Spanish American War fought?
Spain and the US
Puerto Rico and Jamaica
China and Japan
Cuba and the Philippines
What happened to Cuba after the war?
it became completely free
it stayed part of a larger country
it was taken over by the Philippines
it became a US Protectorate
What happened to the Philippines after the war?
it became totally free
it became part of Spain
it was taken over by the US
it fell into the ocean and was never seen again


text:
Separate names with a comma.
Discussion in 'Irrigation' started by Dennis Spencer, Jul 1, 2008.
Must had a blind person installing these .Eight wires and not one waterproof and one not a wire nut.
You gotta like that plastic anchor imitating a wire nut. A definite Hall of Shame nominee.
Prolly hooked to this valve.
you get what you pay for
Because it's green, does that mean it was a ground?
nah, just eco friendly.
well, my hat's off to that guy. not that it's a good idea, but a molly is way down the line of "what i would think to use as a wire nut in a pinch".
at least he was thinking outside of the box.
I used to use TORO screens and squeeze that blue dri-splice gunk into it and push them over a dry splice in a pinch. Haven't done it in many a year but ran into one the other day and they have held up really well.
Ive squeezed silicone into wire nuts when wiring a trailer before. In a jam I may consider that.Greese packs are cheap and have a good mark up.


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Find storage near you
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Indianapolis, IN Self Storage Facilities Near 46218
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2.7 miles away
Storage of America - East Washington
4.1 miles away
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5 miles away
Secure Storage Solutions
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6 miles away
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6.6 miles away
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8 miles away
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8.1 miles away
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9 miles away
Storage Express - Indianapolis - South Lynhurst Drive
9.7 miles away
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Indianapolis Storage: At A Glance
Does Indianapolis student population affect self-storage prices?
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Indianapolis on the SpareFoot blog:
Best Places in the U.S. to Cool Off Before Summer Ends
The neighborhood pool is nice and all, but where are the really cool places you can cool off? SpareFoot was wondering this very thing, so we scoured the Internet to come up with the answer. Taken......Read more.


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Register To Attempt Complete Test
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A new planet is discovered whose mass is the same as that of Earth, although the acceleration of freely falling objects at the surface of this planet is three times larger than that corresponding to Earth. (That is, we have gEarth = 9.8 m/s2 and gnew = 29.4 m/s2.)
If an object were dropped from a height h on this planet, how much time would it take to reach the ground compared to the time it would take on Earth to drop the same distance h? (Assume no atmospheric resistance.)


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If you haven't seen this deal then let me just tell you about it really quick. There is a Bagel Bites coupon in the Publix Grocery Advantage Flyer and there is a printable that you can stack to get them for only $1.09 each!
At Publix:
BUY TWO BAGEL BITES 9 ct – regular price $2.59
use one $2/2 Bagel Bites 9 or 18 ct Publix Grocery Advantage Flyer
use one $1/2 Bagel Bites 9 ct Frozen Products printable (preclipped)
Net Price: $2.18 ($1.09 each!)
Thanks Addicted to SavingExtreme Couponing Tip: You can usually get two prints of most internet coupons. To find them in the easiest possible way, use our preclipped links that take you right to the coupon. Then come back and click the same link to get your 2nd print. This will save you the time spent searching for the coupon.
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This started from Ravelry. We meet every Wed. at the Barnes and Noble in the HarMar Mall in Roseville from 7-10 pm.
Sometimes people show up earlier, so feel free too. They have a coffee shop inside the store so make sure to bring some cash for tasty treats.
We try to get tables together so if you are first get a few together. Per BnN:
"Ordinarily we do not reserve tables in the cafe. Your group is welcome to meet here but I am not able to reserve cafe tables on a regular basis. If you are not able to find space in the cafe please feel welcome to move your group to our event area if is not being used by a large presentation group (usually the 3rd and 4th Wednesdays of the month). I will let the other managers know that I have communicated this to you so they are aware that you may be using our folding chairs and event area to have your meeting. "
See the
for other information and such!
*And a personal note from Susan, HarMar's parking can be tough, so go to the back of the mall for more parking options (around the grocery store).
Barnes and Noble closes the mall entrance at 9 pm so if you do park in back you need to go by then.
Meetup members, Log in
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Genetic variation in the hepatic lipase gene and the risk of coronary heart disease among US diabetic men: potential interaction with obesity
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The −514 C to T polymorphism of the hepatic lipase gene (LIPC) has been associated with lowered LIPC activity and elevated HDL-cholesterol concentrations. Previous findings on the association of this polymorphism with the risk of CHD are inconsistent. Moreover, data on this association among diabetic patients are limited. We investigated the association of the LIPC polymorphism with CHD risk among US diabetic men and evaluated whether this association was modified by adiposity status.
Subjects and methods
The case group consisted of 220 diabetic men who were recruited from the Health Professionals Follow-up Study (years 1986–2000) and were free of cardiovascular disease at baseline, but subsequently developed CHD. A total of 641 diabetic men from the same study but without cardiovascular disease constituted the control group.
No overall association between the LIPC polymorphism and CHD risk was observed. However, we did observe a significant interaction between this polymorphism and BMI in association with CHD risk. Among obese men, after adjustment for age, duration of diabetes and major lifestyle factors, the CT or TT genotype was associated with an increased CHD risk compared with the CC genotype (odds ratio [OR] 2.52, 95% CI 1.08–5.90); the corresponding ORs (95% CI) were 0.99 (0.58, 1.69) for overweight men (25≤BMI <30 kg/m2) and 0.37 (0.17, 0.79) for lean men (BMI <25 kg/m2) (p for interaction 0.001). Stratified analyses by waist circumference (tertiles) showed a similar pattern of interaction (adjusted p for interaction 0.023).
These data suggest that obesity may modify the association between the LIPC C(−514)T polymorphism and CHD risk among diabetic men.
KeywordsCoronary heart disease Diabetes Gene Hepatic lipase Interaction Obesity
coronary artery bypass grafting
Health Professionals Follow-up Study
intermediate density lipoprotein
hepatic lipase
hepatic lipase gene
odds ratio
A decreased plasma HDL-cholesterol (HDL-C) concentration is an established risk factor for CHD among diabetic patients [1]. Allelic variations at the gene encoding hepatic lipase (LIPC) account for up to 25% of the variability in plasma HDL-C concentrations [2]. LIPC is a lipolytic enzyme that is primarily synthesised in the parenchymal liver cells and secreted and bound extracellularly to the endothelial cells in the hepatic sinusoids. It plays a crucial role in remodelling remnant lipoprotein, LDL and HDL [3, 4, 5] as both a catalyst and a ligand. Specifically, it catalyses the conversion of large HDL2 particles to small, dense HDL and acts on large LDL and intermediate density lipoprotein (IDL) particles to form small, dense LDL (sdLDL) particles. In addition, it can facilitate the hepatic uptake of lipoproteins, including HDL, by acting as a ligand mediating the binding and uptake of lipoproteins through proteoglycans and/or receptor pathways [6, 7].
LIPC activity has been reported to be determined by sex [8, 9], body adiposity [10], dietary fat intake [11, 12], alcohol consumption [13, 14], physical activity [15, 16, 17] and, most importantly, by genotype. The human hepatic lipase gene (LIPC) maps to chromosome 15q21 [18]. Four polymorphisms in the 5′-flanking region of this gene (G→A at position −250, C→T at −514, T→C at −710 and A→G at −763) are in complete linkage disequilibrium [19]. They were designated as the −514 C and T alleles together [4, 19, 20]. The C→T substitution disrupts the upstream stimulatory factor 1 binding site present in the proximal promoter region of the hepatic lipase gene and has been shown to decrease transcriptional activity of the LIPC promoter in vitro [21, 22]. Furthermore, it accounted for up to 38% of the variation in LIPC activity [23] and was associated with increased concentrations of plasma HDL and HDL2 and more buoyant LDL particles [6, 20, 24, 25].
The relationship of the LIPC polymorphism to CHD risk has not been clearly established. Findings from several studies suggested a pro-atherogenic role of this polymorphism [24, 26, 27, 28, 29, 30, 31]. The LIPC C(−514)T polymorphism was associated with reduced coronary flow reserve (an early marker of atherosclerosis) [28], coronary artery calcification [26] and increased risk of CHD [27, 29, 30, 31]. However, other studies reported no association or an inverse association with CHD risk [20, 32, 33, 34]. We speculated that some of the inconsistencies may be, at least in part, due to different study population characteristics, such as underlying environmental factors that can affect lipid metabolism. Indeed, in our previous study, we observed that body adiposity significantly modified the association between the LIPC polymorphism and plasma HDL concentrations [35]; only among lean diabetic men was the LIPC polymorphism associated with higher HDL-C concentrations, whereas obesity abolished the beneficial effect of the polymorphism on HDL-C concentrations. In the present study we investigated the relationship between the LIPC −514 polymorphism and the risk of CHD and evaluated whether this association was modified by adiposity status among diabetic patients.
Subjects and methods
Study background
The Health Professionals Follow-up Study (HPFS) is a prospective cohort study of 51,529 American male health professionals who were aged 40–75 years at study initiation in 1986. This cohort has been and continues to be followed through biennial mailed questionnaires focusing on various lifestyle factors and health outcomes. In addition, between 1993 and 1999 (more than 95% of them between 1993 and 1995), 18,159 study participants provided blood samples by overnight courier. Among them, 999 (>97% were people of European extraction) had confirmed type 2 diabetes (at baseline or during follow up, 1986–2000). From this group of diabetic men, we excluded those with reported CHD or stroke at baseline, those who developed stroke or other non-coronary cardiovascular disease during follow-up, and those who developed CHD before diabetes was diagnosed (total exclusions, 138). Among the remaining 861 diabetic men, 220 who developed CHD (i.e. non-fatal myocardial infarction, n=66; fatal CHD, n=18; coronary artery bypass grafting [CABG], n=136) constituted the case group and 641 diabetic men who remained free of CHD and stroke constituted the control group. The 201 cases and 604 control subjects for whom complete data on both LIPC genotype and BMI existed constituted the analytical population of this study. The participants provided written informed consent to be included in the study and all investigations were approved by the institutional review board ethics committee.
Diagnosis of type 2 diabetes
A diagnosis of diabetes was established when at least one of the following criteria was reported on a supplementary questionnaire sent to all men who reported a diagnosis of diabetes in any biennial follow-up questionnaire: (1) one or more classic symptoms (excessive thirst, polyuria, weight loss, hunger or coma) plus a fasting plasma glucose concentration ≥7.8 mmol/l or a random plasma glucose concentration ≥11.1 mmol/l; (2) at least two elevated plasma glucose concentrations on different occasions (fasting ≥7.8 mmol/l and/or random ≥11.1 mmol/l and/or ≥11.1 mmol/l after 2 h or more on oral glucose tolerance testing) in the absence of symptoms; or (3) treatment with hypoglycaemic medication (insulin or oral hypoglycaemic agents). We used the National Diabetes Data Group criteria [36] to define diabetes because the majority of our cases were diagnosed before the release of the American Diabetes Association criteria [37]. Men with type 1 diabetes were excluded. A validation study in a subsample of the HPFS demonstrated that our supplementary questionnaire is highly reliable in confirming diabetes diagnosis [38].
Diagnosis of cardiovascular end-points
The cardiovascular end-points for this analysis comprised fatal CHD, non-fatal myocardial infarction, CABG and percutaneous transluminal coronary angioplasty occurring between the return of the 1986 questionnaire and 31 January 2000. The end-points did not include angina pectoris. Non-fatal myocardial infarction was confirmed by a review of medical records based on World Health Organization criteria that included characteristic symptoms with either typical electrocardiographic changes or elevations of cardiac enzymes [39]. Probable cases of myocardial infarction (no available records but confirmed by hospitalisation and information from telephone interview/letter) were also included in the analysis. Confirmation of CABG or percutaneous transluminal coronary angioplasty was based on self-report only; hospital records obtained for a sample of 102 men in the HPFS confirmed the procedure for 96% [40]. Deaths were reported by next of kin, the postal system, and through records of the National Death Index. Using all sources combined, it was estimated that follow-up for deaths was >98% complete [41]. Fatal CHD was confirmed by reviewing medical records or autopsy reports with the permission of the next of kin. Physicians who reviewed the records had no knowledge of the self-reported risk factor status. Sudden deaths (deaths within 1 h of symptom onset in men without known disease that could explain death) were included in the fatal CHD category.
Measurements of body weight and waist circumference and ascertainment of characteristics of participants
At baseline, participants were asked to report their height (in inches; 1 in=2.54 cm) and current body weight (in pounds; 1 lb=0.45 kg); weight was then updated during the biennial follow-up. In 1987, HPFS participants were asked in a supplementary questionnaire to measure their waist circumference with a paper tape and were given detailed measuring directions. BMI was calculated as weight in kilograms divided by height squared in metres. Waist circumference was used as an indicator of central obesity. Self-reports of body weight, waist circumference and height have been shown to be highly correlated with technician-measured weight, waist circumference and height (r=0.97, 0.95 and 0.94, respectively) in HPFS participants [42].
Participants also provided information biennially on their cigarette smoking, aspirin use and physical activity. Physical activity (metabolic equivalent task [MET] hours/week) was calculated from the reported time spent on various activities, weighting each activity by its intensity level. History of high blood pressure was determined from self-reports preceding the blood collection. Family history of CHD was reported in 1986. Alcohol intake was estimated with a dietary questionnaire in 1986.
Laboratory analysis methods
Details about the blood collection and processing procedure have been reported previously [43]. Briefly, approximately 95% of participants in the present study provided blood samples in 1993 and 1994. Blood samples were collected in three 10-ml liquid EDTA blood tubes, placed on ice packs stored in Styrofoam containers and returned to our laboratory by overnight courier; over 95% of the samples arrived within 24 h. After receipt, the chilled blood was centrifuged, divided into plasma, erythrocytes and buffy coat, and stored in continuously monitored nitrogen freezers at temperatures not higher than −130°C. We requested information on the date and time of drawing the blood sample and the time elapsed since the preceding meal to identify non-fasting (<8 h) subjects. Measurements of lipid profiles were done among diabetic men who developed CHD after their blood samples were collected in 1993–1994 (n=109) and their controls (n=604). All lipid profiles were assayed in the laboratory of N. Rifai (The Children's Hospital, Boston, MA, USA), which was certified by the NHLBI/CDC (National Heart, Lung and Blood Institute/Centers for Disease Control) Lipid Standardization Program. All assays except the ELISA and RIA employed a Hitachi 911 analyser (Roche Diagnostics, Indianapolis, IN, USA). Concentrations of total cholesterol, triacylglycerols and HDL-C were analysed simultaneously with enzymatic assays with CVs of 1.7, 1.8 and 2.5%, respectively. LDL-cholesterol (LDL-C) was determined by a homogeneous direct method (Genzyme, Cambridge, MA, USA), with CV <3.1%. Measurement of HbA1c was based on turbidimetric immunoinhibition using haemolysed packed red cells. The intra-assay CVs at HbA1c values of 5.5 and 9.1 were 1.9 and 3.0%, respectively.
DNA was extracted from the buffy coat fraction of centrifuged blood using the QIAmp Blood Kit (Qiagen, Chatsworth, CA, USA). The genotyping technique was Taqman SNP allelic discrimination by means of an ABI 7900HT Sequence Detection System (Applied Biosystems, Foster City, CA, USA). Primers and probes are available on request.
Statistical analysis
Frequency distributions of characteristics of study subjects were examined according to case–control status. Student's t tests and χ2 tests were used for comparisons of means and proportions. Because of the small number of subjects homozygous for the less common allele (genotype TT; nine cases, 25 controls) and similar magnitude of associations with CHD risk for individuals with this genotype and heterozygotes (genotype CT), individuals with genotypes CT and TT were grouped together.
Unconditional logistic regression was used to calculate odds ratios (OR) and 95% CIs for the association between the LIPC genotype and CHD risk adjusted for risk factors for CHD. Adjustment for baseline variables (age, smoking status [never, past, current smoker], physical activity [quartile], alcohol consumption [non-drinker, <5.0, <10.0, >10.0 g/day], total energy intake), and duration of diabetes changed the OR slightly, but we kept these variables in the final model because of their recognition as risk factors for CHD and interpretable variables that may account for the heterogeneity of study participants. Adjustment for other covariates, such as family history of myocardial infarction, aspirin use, history of hypertension and hypercholesterolaemia at baseline, did not show a significant effect on the ORs, and because they might be intermediates for the association they were not included in the final models.
Stratified analyses were conducted to examine whether the association between the LIPC polymorphism and CHD risk was modified by overall body adiposity status (lean, BMI <25; overweight, BMI 25.0–29.9; obese, BMI ≥30 kg/m2) defined using the World Health Organization criteria [44], and central obesity status (waist circumference: tertile [high, medium, low]) at baseline. Interactions between LIPC genotypes and BMI and waist circumference were assessed using a cross-product term between genotypes and these factors. Tests for interactions were performed using likelihood ratio tests by comparing two nested multivariate models with and without the interaction term. All reported p values are two-tailed and statistical significance was defined at the α=0.05 level. All analyses were performed with SAS version 8.12 software (SAS Institute, Cary, NC, USA).
Comparison of cardiovascular risk factorsa between CHD cases and controls at baseline (1986) among US diabetic men
CHD cases
p value
Age (years)
BMI (kg/m2)
Waist circumference (cm)
Family history of MI (%)
History of hypertension (%)
History of hypercholesterolaemia (%)
Physical activity (MET-hours/week)
Total energy intake (kcal/day)
Alcohol consumption (g/day)
Never smokers (%)
Aspirin users (%)
Plasma lipoproteina (mmol/l)
Association between LIPC genotypes and the risk of CHD among US diabetic men
LIPC genotype
Cases (201)
Controls (604)
1.00 referent
1.00 referent
1.07 (0.76, 1.50)
0.96 (0.67, 1.38)
1.06 (0.74, 1.50)
0.93 (0.64, 1.35)
1.17 (0.52, 2.63)
1.21 (0.52, 2.83)
Association between LIPC genotypes and the risk of CHD according to BMI and waist circumferencea among US diabetic men
LIPC genotype
Cases (201)
Controls (604)
BMI (kg/m2)
1.00 referent
1.00 referent
0.51 (0.26, 1.01)
0.36 (0.17, 0.79)
1.00 referent
1.00 referent
1.08 (0.65, 1.86)
0.99 (0.58, 1.69)
1.00 referent
1.00 referent
2.54 (1.27, 5.10)
2.52 (1.08, 5.90)
p for interaction
Waist circumference (cm)
Lowb (<96.0)
1.00 referent
1.00 referent
0.77 (0.39, 1.51)
0.57 (0.27, 1.22)
Mediumb (96.0–105.2)
1.00 referent
1.00 referent
0.84 (0.43, 1.64)
0.86 (0.42, 1.75)
Highb (≥105.2)
1.00 referent
1.00 referent
2.24 (1.15, 4.37)
1.99 (0.98, 4.10)
p for interaction
Similarly, we observed a significant interaction between the LIPC −514 polymorphism and waist circumference (multivariate-adjusted p for interaction=0.023) in association with CHD risk. The LIPC −514 polymorphism was related to an elevation of CHD risk confined to diabetic men with greater waist circumference. Among 217 men whose waist circumference was equal to or greater than 105.2 cm (the highest tertile of the study participants), the CT or TT genotype was associated with approximately two-fold increased risk of CHD (multivariate-adjusted OR=1.99, 95% CI 0.98, 4.10). Corresponding ORs were 0.86 for men with waist circumference in the middle tertile and 0.57 for those in the lowest tertile.
Considering that altered LIPC activity has been related to lifestyle factors, including dietary fat intake, physical activity, and alcohol consumption, we further examined whether these factors modulated the association between the LIPC −514 polymorphism and CHD risk. No statistically significant interactions between these factors and the LIPC −514 polymorphism in relation to CHD risk were observed.
In this study of US diabetic men, the association between the LIPC C(−514)T polymorphism and CHD risk was modulated by both overall adiposity and central obesity. Among obese men, the CT or TT genotype was associated with significantly increased risk of CHD compared with those with the CC genotype. However, among lean men this polymorphism was associated with a reduction in CHD risk.
Previous data on the relationship between the LIPC C(−514)T polymorphism and CHD have been inconsistent. While several studies suggested a pro-atherogenic role of this polymorphism [24, 26, 27, 28, 29, 30, 31], others reported no association or even an inverse association with CHD risk [20, 32, 33, 34]. For instance, in a Danish cohort, participants with the TT genotype were observed to have a 1.5-fold (95% CI 1.0, 2.2) increased risk of ischaemic heart disease compared with those with the CC genotype [29]. The extent of coronary atherosclerosis determined by angiography was reported to be higher in participants with the T allele [27]. The LIPC −514 T allele was also reported to be associated with a decrease in coronary flow reserve [28] and the presence of subclinical CHD [26]. In contrast, no association of the LIPC C(−514)T polymorphism with the risk for CHD or coronary artery disease was observed in a study of Finnish men [20]. In another cohort of Finnish men, men with the CC genotype had elevated risk of acute myocardial infarction compared with those having the CT or TT genotype (relative risk=1.5) [34]. Some of the inconsistencies may be due, at least in part, to different study population characteristics, such as underlying environmental and/or physiological characters, which can affect LIPC activity and HDL metabolism. In the present study we found that the association between the LIPC C(−514)T polymorphism and CHD risk was dependent on overall adiposity and central obesity status. Previous studies that did not account for these gene–environment interactions may have obscured the effect of this polymorphism on CHD risk.
The precise mechanism by which obesity modifies the association between the LIPC C(−514)T polymorphism and CHD risk has yet to be elucidated. The LIPC −514 polymorphism is a key determinant of LIPC activity. The T allele has been shown to decrease transcriptional activity of the LIPC promoter in vitro [21, 22] and to account for up to 38% of the variation in LIPC activity [23]. LIPC activity is also affected by body adiposity; both BMI [10] and intra-abdominal fat [45] were strongly and positively associated with LIPC activity. We speculated that the observed interaction between the LIPC polymorphism and adiposity in association with CHD risk may act through their influence on LIPC activity and be related to the dual roles of LIPC activity in lipoprotein metabolism. LIPC activity has both pro-atherogenic and anti-atherogenetic properties [4]. LIPC catalyses the conversion of large HDL2 particles to small dense HDL by modulating the triglyceride and phospholipids content of these particles. It can also act on large LDL and IDL particles to form small dense LDL particles [3, 4, 5]. On the other hand, as a ligand, LIPC can be potentially anti-atherogenic through stimulating reverse cholesterol transport and clearing IDL [4]. The LIPC C(−514)T polymorphism associated with lower hepatic lipase activity may, therefore, have both anti-atherogenic and pro-atherogenetic effects. Which effect prevails may be dependent on other factors. It is possible that, in the presence of obesity-related metabolic changes among diabetic patients the pro-atherogenic property related to the LIPC polymorphism outweighs the anti-atherogenic property, which may consequently lead to an elevated risk of CHD. Conversely, among lean diabetic men, the anti-atherogenic effect may prevail. The relationship among the LIPC −514 polymorphism, adiposity and CHD could be complicated by pathophysiological and metabolic changes associated with diabetes. We are unaware of experimental data on the relationship among diabetic patients.
In agreement with the findings from the present study, an interaction of similar direction between the LIPC polymorphism and adiposity in association with HDL-C concentrations was observed in some studies [35, 46]. In a study of French-Canadian men [46], only lean carriers of the T allele had higher plasma HDL-C levels compared with lean CC homozygotes. The beneficial effect of the T allele was abolished in the presence of visceral obesity. Similarly, among 780 US diabetic men who were free of cardiovascular diseases at the time of drawing blood (the source cohort of the controls in the present study), we observed that overall adiposity significantly modified the association between the LIPC polymorphism and plasma HDL-C concentrations [35]. Only among lean men (BMI <25 kg/m2) was the T allele associated with significantly elevated plasma HDL-C levels; there was no association in overweight or obese men. In the present study, the interaction between adiposity and the LIPC polymorphism was attenuated but remained significant after controlling for plasma HDL concentrations, which indicated that the observed interaction was due in part, but not entirely, to a differential effect of the LIPC −514 polymorphism on HDL concentrations by obesity status. Experimental studies with measurements of the LIPC polymorphism, LIPC activity and lipoprotein profiles are warranted to explore the physiological and functional significance of this polymorphism for atherosclerosis and CHD risk in the context of obesity.
One limitation of our study is that the HPFS does not represent a random sample of US diabetic men. The variant allele frequency (0.20) in this study, however, is in agreement with that reported in previous studies among people of European extraction [24, 47]. Secondly, we cannot exclude the possibility that the observed association with CHD is due to linkage disequilibrium with other, undiscovered variants in this gene or to its interaction with other genes important in determining plasma HDL-C levels or CHD risk; for example, the apolipoprotein AI/CIII/AIV, cholesteryl ester transfer protein and lipoprotein lipase loci. Thirdly, we cannot rule out the possibility that the observed significant interaction may be due to residual confounding by unmeasured factors. We controlled for major measured risk factors for CHD and the findings did not change appreciably. Lastly, we cannot completely exclude the possibility that our results may be due to chance. It should be noted, however, that we conducted the present study based on our a priori finding of significant interactions between the LIPC −514 polymorphism and adiposity in determining plasma HDL concentrations [35]. Nonetheless, it will be important to confirm these findings with additional investigations among large samples of diabetic patients.
In conclusion, we observed heterogeneity of the association of the LIPC C(−514)T polymorphism with CHD risk according to obesity status among diabetic men. The increase in CHD risk associated with the polymorphism was observed only for obese men. These data support a role for gene–environment interaction in susceptibility to CHD among diabetic patients and, if confirmed, may provide an additional impetus for reducing obesity to prevent CHD.
This research was supported by awards from the National Institutes of Health (HL 65582 and HL 35464).


text: This 1965 Chevrolet Corvair Monza convertible is an excellent running, "driver" quality, affordable classic. It has the 110hp engine and a 4 speed manual transmission. New upgrades include: brand new convertible top, window, window well and pads, new carpet and 14" tires. Shade's is a Corvair specialty shop and we have over 40 Corvairs for sale. Please feel free to call with me with any questions @ (402) 460-7097 or check out our website at www.shadesclassiccars.com Thank you for your interest! Chris Shade


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13 March 2004
Dullah Omar, South African Minister of Transport and Anti-Apartheid Lawyer, Dies of Hodgkins Disease
The Treatment Action Campaign (TAC) expresses its condolences to Farida Omar and the family of Dullah Omar. Minister Omar died early Saturday morning of Hodgkins Disease, a form of cancer that affects lymphatic tissue.
Minister Omar was a human rights lawyer who took on the Apartheid regime. He dedicated most of his adult life to fighting for the rights of people oppressed by the National Party government, especially the poor. He frequently did not charge for his services and made enormous personal and financial sacrifices for his clients. After the fall of Apartheid, he became Minster of Justice, then Minister of Transport. But he and Farida continued to live in the same modest house in Rylands, Cape Town.
Minister Omar was a mentor to TAC chairperson, Zackie Achmat when Achmat was a young political activist. He had a substantial influence on Achmat's undertanding of the law and its usefulness for redressing injustice.
Our thoughts are with Minister Omar's family during this difficult time.


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At present, the only way of deciding which eggs to use in IVF is to examine them through a microscope.
This gives doctors little chance of picking up the kind of abnormalities that cause the procedure to fail.
Scientists have now developed a new screening technique that could allow them to determine, for the first time, which of a woman's eggs are most suitable.
The test is particularly useful for older women, as their eggs are often of lower quality than younger women.
It is already being tried in some clinics in Britain, with early results suggesting that pregnancy rates in older women following the treatment as much as double.
In the ground-breaking trial, conducted by the European Society of Human Reproduction and Embryology, the test accurately predicted whether a woman's egg was normal in 90 per cent of cases.
It involves removing waste cells, known as polar bodies, from the egg, which are produced shortly before and after fertilisation, to see if they have the correct number of chromosomes.
If the polar bodies have the correct number, so does the egg and this improves the chance of implanting in the womb and creating a successful pregnancy.
Scientists at the University of Bonn and the Sismer centre in Bologna tested polar bodies from 226 fertilised eggs from 41 women. Only one in four eggs from this group of women was normal.
The test can be completed within 12 to 13 hours, meaning it can fit into a normal cycle of IVF.
Abnormalities in the number of chromosomes in the egg are thought to account for a significant proportion of failed IVF cycles, miscarriages and conditions such as Down's syndrome.
Prof Joep Geraedts, who coordinated the trial, said the test could identify women who produce abnormal eggs sooner and allow them to consider using donor eggs instead. However he said it was too early to recommend the test for older women because it could add about £2,000 to the cost of an IVF cycle. A larger trial is planned.
"We hope this approach will in future effectively improve results in assisted reproduction," added Prof Geraedts.
Simon Fishel, director of Care Fertility, which has already treated 150 women with the test, said: "I think it's very exciting. We probably have a technology that is robust and is an objective assessment of the viability of embryos."
The procedure, called 24sure, has been developed by the genome technology company, BlueGnome. The above video was provided by 24sure.


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Hi Richelle,
I asked my suppliers for the photos and they said they were happy for me to copy and paste anything on their website to use. However, i sell on EBAY and i am finding that i cant paste photos onto listings (you can on the description part but not the thumbnail as that needs to be downloaded).
I am sp stuck, i dont know what to do now!!!!
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text:
I'm still re-watching every Lost episode at my house -- I think that's gonna keep me busy for awhile. However, if you need a fresh DVD this week, we've got some possibilities:
Release o' the week: Where the Wild Things Are. Spike Jonze brings the children's classic to the big screen in this adaptation co-written by Dave Eggers. Though my favorite scenes were the pre-monster moments at the beginning, the wondrous visuals and inspired soundtrack are a delight to behold.
- Tell Them Anything You Want. On a related note, this documentary delivers a portrait of Wild Things author Maurice Sendak.
- Gentlemen Broncos. Maybe it wasn't a must-see in the theater, but Napoleon Dynamite director Jared Hess' offbeat sci-fi-inspired comedy has its moments. Not surprisingly, Flight of the Conchords' Jemaine Clement steals the movie.
- Ponyo. Renowned filmmaker Hayao Miyazaki returns with this animated tale loosely based on The Little Mermaid.
- We Live in Public. I'm very eager to see this documentary about Internet pioneer Josh Harris that examines the effect "living in public" is having on our society.
- The Private Lives of Pippa Lee. Robin Wright, Keanu Reeves, Winona Ryder and others star in this drama about the many lives one woman has led.
- 2012. John Cusack faces the apocalypse.
Also out: Alice, Alice in Wonderland (1966), Curious George 2: Follow That Monkey, Believe: The Eddie Izzard Story, Designing Women: The Complete Third Season, Hell's Kitchen: The Complete Second Season, Ninja
Blu-ray highlight: The Neverending Story is out on Blu-ray today!
Related news: The Imaginarium of Doctor Parnassus comes out April 27.
Next week: Up in the Air arrives.
Whitney has been writing about pop culture for USA TODAY since 1999, when Pop Candy began as a weekly column. Her interests include music festivals, mustaches, Lost, comic books and Andy Warhol. She lives in New York City. More about Whitney | E-mail Whitney


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Gifts of the Body and the Needs of Strangers
Murray, Thomas H.
Bibliographic Citation
Hastings Center Report. 1987 Apr; 17(2): 30-38.
Relationships governed by markets keep moral and social dimensions to a bare minimum. Gifts, by their open-endedness, defy such minimalization. Impersonal gifts such as blood or body parts or charity may not regulate relationships between specific individuals, but they serve other functions by regulating larger relationships and honoring important human values, precisely those threatened by massive and impersonal bureaucracies.
Altruism; Biomedical Research; Blood; Blood Donation; Common Good; Contracts; Donors; Gifts; International Aspects; Moral Obligations; Motivation; Obligations to Society; Organ Donation; Organ Donors; Patients; Patients' Rights; Property Rights; Property; Remuneration; Research; Rights; Social Interaction; Tissue Donation; Transplant Recipients; Values; Volunteers;
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On the Human Body as Property: The Meaning of Embodiment, Markets, and the Meaning of Strangers Murray, Thomas H. (1987-06)
Doctors, Drug Companies, and Gifts Chren, Mary-Margaret; Landefeld, Seth; Murray, Thomas H. (1989-12)The authors analyze the complex practical and ethical issues surrounding the phenomenon of gift giving by drug companies to physicians. They consider the ethical implications of the practice, pointing out that whenever a ...


text:
Toll Free: (888) 223-2545
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Hours:9:00 am - 8:30 pmM-F Eastern Time
The Legacy Crystal collection adds simple luxury to your decor. This drawer pull features a center crystal mounted on a shapely base in your choice of three classic finishes. Install this beauty anywhere in your home for a touch of sparkle. This smaller sized knob is ideal for both cabinets and furniture.Dimensions: 3 11/16" W. Projection: 1 1/8". Base: 11/16" D. Center-to-center: 3".
All Site Contents ©2015, House of Antique Hardware, Inc. Antique-By-Hand® is a registered trademark of House of Antique Hardware, Inc.


text: Hey guys, I was wondering if anyone can help me out. I realized that my website is not seo optimized for what I am targeting... How do I change the heading or title to rank for what I am going for? Like digital point.... Their website is "digital point", but they rank for Internet marking forum. Like where did they add that phrase. "Online Internet Marketing & Search Engine Optimization Forum"


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Spiced Round of Beef
READY IN: 3hrs 15mins
Recipe by Derf2440
The spicy marinade gives the beef a wonderful flavour, while slow cooking keeps the meat very moist. Spoon the veggies and any sauce over the baked potatoes or serve separately. From Cooking for Diabetics.
Top Review by kathleengapa
It's great!
See Discussion:1 Review
Ingredients Nutrition
- 2 teaspoons coriander seeds
- 1 teaspoon anise seed
- 1 teaspoon fennel seed
- 1 teaspoon dried thyme
- 1 teaspoon ground cloves
- 1 teaspoon sea salt
- 1 teaspoon pepper
- 1⁄2 teaspoon ground cinnamon
- 2 1⁄2 cups dry white wine
- 2 1⁄4-2 1⁄2 lbs round beef
- 2 tablespoons olive oil
- 2 onions, chopped
- 2 carrots, chopped
- 2 stalks celery, chopped
- 1 parsnip, chopped
- 4 green beans, chopped
- 8 mushrooms, chopped
- 1 1⁄4 cups beef broth or 1 1⁄4 cups chicken broth
- 7 tablespoons dry red wine
- 2 sprigs fresh parsley
Directions See How It's Made
- Serve with oven baked potatoes.
- Put the coriander seeds in a mortar and pound them with a pestle.
- Stir in the rest of the spices and seasonings, then pour the mixture into a bowl and stir in the white wine.
- Put the beef in large zip lock bag, pour the marinade over the beef, push the air out of the bag and seal it.
- Massage the marinade around the beef and refrigerate for about 24 hours, turning and massaging occasionally.
- Preheat the oven to 300f degrees.
- Heat the oil in a deep casserole just large enough to hold the beef snugly.
- I use my cast iron dutch oven.
- Add all the vegetables and cook over gentle heat for 15 to 20 minutes, or untl they start to soften.
- Lift the beef out of the marinade and place on top of the veggies.
- Strain 1 1/4 cups of the marinade into a measuring cup and add the broth and the red wine.
- Pour the liquid over the beef.
- Add the parsley, cover and place in the oven.
- Bake for 2 to 3 hours, or until the beef is tender.
- For the last hour, wash and score the potatoes.
- Place potatoes on oven grate around the outside of the casserole.
- Bake 1 hour, or until fork tender.


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2014 BROYEUR POUR MINI-PELLE DE 1.5 A 2T BERTI MINI/SB in France
- Location:
- France
- Price:
- No price
- Manufacturer:
- Berti
- Model:
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offer you :
Compact hydraulic flail head suitable for grass and light brushing up to 1 cm in diameter. This model can be mounted on mini diggers with a weight of 1.5 to 2 tons.
It can be used in several applications, for example in the building, maintenance of green areas and agriculture.
Standard equipment: knives, hydraulic gear motor (with or without external drainage), sensing roller, hydraulic hoses with protective sheath, belt transmission, shoe set and group "Berti Fluid Box Compact" valves (max 60 lt / min).
Accessories on request: custom-made saddle with axes.
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15 Nov Pic(k) of the week 47: SUPERMOON RISE OVER DUBAI
Yesterday was "Supermoon" night; a relative new word for a moon which is brighter and larger than normal. Last nights full Supermoon was 14% larger and 30% brighter than a "standard" full moon; something that hadn't occurred to the same scale since 1948 and for which we will have to wait till 2034 to see an even larger one.
This coincidence happens when the moon which is on an elliptical pattern around the Earth, is the closest just at the full moon moment, resulting in an apparent larger moon disk. Even though 14% extra is a lot for a supermoon, I saw a lot of people being disappointed in how "small" it looked.
Anyway, plenty of reason to go out there to try and photograph the moment! As a lot of other photographers were using super telephoto lenses in order to show how large the moon was, I elected to try and document the first glimpse of the moonrise itself from within the city. Something that is not easy to achieve with all the high rise buildings around.
Luckily we have IOS applications like PhotoPills, which will predict where exactly the moon is about the rise.
Although I wasn't 100% sure if the moon would fit between the two tall buildings, it turned out to be a success.
Image details:Fujifilm X-T2 with the XF50-140 f2.8 lensISO 800, f5, 1/10s, 90mm (135mm full frame equivalent)Lightroom CC for RAW developmentNik ColorEfex pro4 for optimal detail and contrastAs I'm pretty happy with the overall quality of the image, I uploaded a copy into my Architectural portfolio, here. …


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eBay Marketplace Strategy
ChannelAdvisor believes that multi-channel selling is a critical key to online success. Our integration with eBay.com presents a great opportunity for our partners. eBay's philosophy is committed to providing the best buyer experience and customer satisfaction on the web. This philosophy has worked well for them in growing a dedicated base of eBay shoppers. This article will outline some strategies related to the basic stages of selling on eBay.com.
Optimizing for Best Match
Once you have successfully listed your items on the eBay Marketplace you will always want to look for ways to improve your listing performance. One of the best ways to do this is to optimize your listings so that they appear in eBay's Best Match Results. Below is a checklist of items that you should be concentrating on in order to increase your product visibility on eBay.
Category-Specific Strategy Information
Each eBay category requires their own distinct data points and values. View the following category specific pages to learn about the different strategies involved for each category.
Additional eBay Strategies for Success
Helpful eBay Links
Below is a list of useful links to eBay's Help documentation.
eBay Re-Instatement Tips
Did you get kicked-off eBay? Read more about what you can do to try and re-instate your account.
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Lawrenceburg Vacation Packages
From Lawrenceburg, it's roughly 18 miles (29 kilometers) to the east to Cincinnati and 75 miles (121 kilometers) to the south to Lexington.
Do visit the Hollywood Casino when spending time in Lawrenceburg.
Discover the unique landscapes, architecture and people of Central Indiana, by taking a road trip through other villages, cities and towns near Lawrenceburg. For more places to explore, check out the World of Golf and Champion Window Field in the vicinity of Florence, which you'll find roughly 14 miles (23 kilometers) to the northwest of Lawrenceburg.
When you are ready to venture further afield visit the nearest regional area. Cincinnati is approximately 18 miles (29 kilometers) away and features attractions like Riverbend Music Center, Theodore M Berry International Friendship Park and Aronoff Center for the Arts. Music Hall, Contemporary Arts Center and Duke Energy Convention Center are also good places to head to.
If you are after things to do inside, you can't beat Central Indiana's excellent history museums. These are great places to to learn about the local lore and culture and find a unique memento.
Relax like the locals in the Central Indiana region. Go picnicking and bird watching while you are here.
Even the best vacation can't go on forever, so when it's time return home, head to the nearest major airport in Cincinnati, 11 miles (18 kilometers) away.
Accommodation in Lawrenceburg
Pre-booking a relaxing place to stay is a key element of any travel experience. Expedia gives easy access to the finest hotels in Lawrenceburg.
For those celebrating a special occasion, be sure to check out the amenities at the Comfort Inn, at 1610 Flossie Drive, and the Baymont Inn and Suites Lawrenceburg, at 1000 E Eads Parkway. Should those options not fit the bill, the Empire House Hotel, 114 South Front street, or the Rising Star Casino Resort, 777 Rising Star Drive might be a better fit.


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Moon dust that Neil Armstrong collected during the first lunar landing was displayed Thursday at a New York auction house — a symbol of America's glory days in space now valued at $2 million to $4 million.
The late astronaut brought the dust and some rocks back to Earth in an ordinary-looking bag.
It's one of 180 lots linked to space travel that Sotheby's is auctioning off July 20 to mark the 48th anniversary of the pioneer lunar landing on that date in 1969.
The moon dust is the first sample of Earth's satellite ever collected.
The bag has had a storied existence, a decades-long trajectory during which it was misidentified and nearly landed in the trash....