text: ALBUQUERQUE, N.M., Aug. 13, 2013 (GLOBE NEWSWIRE) -- EMCORE Corporation (Nasdaq:EMKR), a leading provider of compound semiconductor-based components and subsystems for the fiber optics and space solar power markets, today announced the release of the new EMP-3, EMP-4 and EMP-7 Fiber Optic Gyroscope (FOG) modules, expanding the Company's EMP FOG platform with the latest generation navigational grade fiber optic gyro technology. The EMP-3, EMP-4 and EMP-7 augment EMCORE's FOG product line between the tactical grade EMP-1 and the navigational grade EMP-1.2K. These latest models feature performance specifications ideal for medium accuracy platform stabilization applications such as camera systems used in aircrafts and Unmanned Aerial Vehicles (UAVs), as well as a variety of other guidance, navigation and aeronautics applications. The availability of these new navigational grade models provides customers with greater flexibility to choose the performance parameters that best meet their application. EMCORE's latest EMP-3, 4 and 7 FOG modules operate over a broad distance range with a typical bias drift from 0.2 degrees per hour for the EMP-3, to a mere 0.005 for the EMP-7. Bias drift is an important measure of accuracy and precision of the FOG, with lower bias models delivering higher performance overall. Like all EMCORE FOG modules, the EMP-3, EMP-4 and EMP-7 feature advanced integrated optics and closed-loop Digital Signal Processing (DSP) electronics to deliver higher accuracy, lower noise, greater efficiency, improved drift stability and higher linearity than competing technologies. EMCORE develops most of the key FOG components internally including the optical transceiver and the lithium-niobate modulator. This allows performance parameters to be customized to specific customer requirements at price levels equivalent to, or less than that of lower-performance open-loop designs. Like the original EMP-1 and EMP-1.2K modules, the EMP-3, 4 and 7 are compact, lightweight and rugged, with very low power consumption requirements.


text:
Jaguar Virtual Windshield Brings Video Games to Life
Jaguar is developing a new type of head-up display that covers the entire windshield, bringing a video game like display screen to life.
The 'Virtual Windscreen' will be able to display information onto the windshield in real time, and the brand has released a teaser video which shows how the technology would work at the race track.
A virtual line can be displayed directly on the road to show the driver the best way to take a corner, and it will change color based on when the brakes should be applied. Driver's can also race against a virtual version of themselves, recorded from a previous lap and displayed directly on the windshield. The system can even set up virtual pylons to create a driving course on flat asphalt.
Thanks to eye-tracking technology, the images will appear to be 3D without the need of special glasses. Of course, speed, rpms, fuel level and other essential car stats would also be included in this head-up display.
Jaguar did not mention anything about production or when we can expect to see such technology in the real world, so for now it is simply a concept.
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Discuss this story at our Jaguar Forum

subset: commoncrawl


text:
It only takes a minute to get started. Fill out our uncomplicated sign up form and login to the site.
This step is optional but will drastically boost your chances of your profile being viewed by interested members. Tell people about yourself, your hobbies and atach your nicest photo of yourself.
Use our website's state-of-the-art search to discover over 60s members who match your requirements. Or just leaf through listings and discover daters that appeal to you.
Discovered someone who meets your requirements? Send them a word or two or just a wink and take it from there. With a little luck you'll be on your way to a lifetime of happiness.
You won't regret it


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Anthony: Ok lets just get into it... You popped James Huntsman's cherry so to speak, even though he fucked the shit out of you :) What was this like to be his "first" on camera fuck? Quite the honor, you lucky fucker.
Cody: It was interesting; he was quite nervous and not all too sure what to do. It was similar to teaching someone how to top for the first time. He pretty much had 2 modes - hard and fast, and hard but not quite so fast, though he didn't really know much about the prostate. With some direction I was able to get him to hit the spot a few times. It's a weird dynamic with a scene partner who has reservations about what you're doing in the scene, sometimes nervous or not wanting to perform certain actions, I guess being his first, so to speak, is something to note, though I guess I'd actually rather have a scene with a slutty gay boy who knows what he's doing rather than a straight boy who I have to teach every step of the way. However I give him props, Huntsman was a very relaxed guy to work with, and even though he had his restrictions he was very cool about it all.
Anthony: So, you've also worked with Rod Daily, Trystan Bull and Alex Waters for Next Door Studios. Can you tell us your experience working for NDS, and is it anything like it's been painted out to be lately?
Cody: I've been paired almost entirely with straight scene partners. While I don't want to get into specifics of any particular performer, I will say that the ones which are open to perform are far easier to work with.Yes, there are times when I am really into my scene partner and it doesn't really matter to me what their restrictions are. I just enjoy touching them and servicing them. However this is not usually the case. When you are paired with someone who does not perform any number of various sensual interactions with their scene partner, particularly when they are less your type, it is a major turn off. For instance if I am partnered with a boy who's my type I could almost care less what we end up doing I'll enjoy it anyway. But if I am paired with a partner who is not my type then the sensual or even basic sexual contact becomes necessary to not only enjoy the scene but to simply stay hard and aroused enough to keep going.
Besides just working on set, it is really clear in the video after when scene partners are acting their way through it instead of actually interacting to illicit the responses they give off. There are definitely straight guys who perform, and do so very well. They either act the part and get involved with their scene partner or actually get into it. But when you have a scene partner who is straight and does not perform, not only does it make filming hard but it also makes you look bad in the video when you can clearly tell everything you do or say is forced because no one is really into what is going on. Outside of filming, the studio is very relaxed, very nice staff that are awesome to hang out with and work with. But be careful as sometimes the dinner that they serve is not necessarily the best food for a bottom to eat the night before a morning shoot. My impression of the studio is that the people are generally pretty cool but when it comes to picking the "talent", they should give it a second look.
Anthony: Sometimes I can get into kinky stuff, and watching you at Bound Gods and Bound In Public is quite fun. What is it like to work a shoot like these and how does it differ from a normal sex shoot? What is the kinky shit that really gets you off?
Cody: Honestly the main difference is just the time it takes to do the rigging. It can take quite a while to properly tie someone up for a scene, sometimes longer than the scene itself. However there is a very different dynamic usually between all parties involved than from a normal shoot. With kinky stuff you have to constantly check the model to see if they are okay and such, ensure their limits are respected, etc. Additionally, a lot of models who do kinky porn develop a headspace for their character, be it dominant or submissive, and this can take a few minutes or longer to both get into and get out of. I won't get into the psychology of a headspace but I will say that you can completely lose yourself in the scene if you get too deep in a headspace, and this can be both good and bad depending on what's going on. It's quite interesting to see a person's normal personality and their personality once they are in the headspace of their role; some of the sweetest guys I know can be the harshest doms. I could go into more detail if you want me to, but I think that this answers the first part of your question.
For me, you name a fetish and I can pretty much find a way to enjoy it. I have a few hard limits that I will never violate or let someone else violate, but most things I can enjoy quite thoroughly. Outside of specific fetishes, I'm totally versatile as well as a switch. So I top, bottom, dom, sub, and have plenty of experience in all of these positions. In fact, contrary to what you see on camera I usually am a dominant top in my bedroom. So much so that I teach rope bondage and do suspension bondage set-ups right in my bedroom, designed rigging and such myself and put it all together. Though I do consider myself 50/50 as far as which I enjoy the most dom or sub, I will say that while I usually dom others, I will rarely pass up the chance to sub for some really awesome doms I know. I enjoy both but it takes a lot more trust to submit to someone than it takes to dominate someone, and that trust has to be garnered before you play, so unless a dom who I trust and respect their work is available I generally assume that role with the boys I play with.
Anthony: Okay lets peel back those layers, boy. Where you from? ASL :) Haha, gives us your background of how you got into porn. Is your family supportive?
Cody: I'm from 19 miles Upstate NY, and it all started when I hooked up with a cute guy who was passing through the area. From his profile I kind of guessed that he did porn - a few days later I asked him if he did, he said yup. Asked how I can get into it, and he gave me some information on the subject. It was surprisingly easy, actually. I figure for a full time student there's not really a better job; low hours, high pay, travel... it's a perfect way to pay for school and not be bogged down without any time to get your work done. Plus with my career choice there really is no way this will affect my future career options.
As far as family is concerned, a few family members know I do porn and am as active in the gay community as I am. Most in my family just know that I am gay, though, and know nothing beyond that. My parents know I'm gay and are supportive, however I feel they may not be quite as supportive of my part time job (porn :P) or of the vast quantities of sex gear (rubber, leather, rope, etc) that I have. So I am keeping those particulars to myself and the few family members who are open enough to accept all that without being weirded out or judgmental.
Anthony: Ok, what is with the bisexual thing? You love getting pounded in the ass :) But do you have a relationship off set? Would you or have you been involved in a gay relationship? If not, I'm available ;) Do you have a certain reference in guys?
Cody: So generally speaking I consider myself gay. There are a few women who I find attractive, though usually superficially so, and it's usually the more androgynous or tomboy girls anyway when it comes to this. I guess I'm a 5 on the Kinsey scale, so technically a wee bit bi, though ever since I was 12 or so I've been progressing from a 3 to where I am now. I used to be more bi and discovered my sexuality to sway much more on the gay side of things in the past year or two. I suppose if you really think about it I guess I was straight for pay for the one straight scene I did. The bondage and such was the main turn-on for me so I enjoyed it anyway. Even though the girls in that scene were hot by straight guy standards, they were not my type.
As far as a relationship, that would probably be exclusively with guys. My interest in girls is mostly that on occasion I could get hard from looking at a girl that is my type but not enough of an attraction to be serious about it. I generally just consider myself gay now, and this past year has affirmed this through extensive exploration, though a 5 on the Kinsey scale is technically the more appropriate than a 6. My past relationships (almost all of which were gay) have been hit or miss, however I never had one end badly. Any relationship I was in that ended did so under mutual and peaceful terms. I've had a few relationships but have yet to have something I would consider long term yet. Though I will say I am looking, I want nothing more than to be in a serious relationship with a boy right now.
As far as what I'm looking for, physically I'm most attracted to twinks. Emotionally I'm attracted to people I can click with and express myself to comfortably. Intellectually I like intelligence and maturity. However I also know that these traits don't necessarily come in a single package nor is my image of the perfect guy really perfect. It's really a synergistic approach when it comes to looking at guys; it's the whole person, not a list of traits and characteristics. There are infinite combinations of traits all of which would yield a wonderful boy, so you can't really judge someone by a particular trait. You can only set a general "I usually like this in a guy", but as soon as you say "I only like this in a guy" you limit yourself and ignore the whole person which may be a better match than anyone else you may come across.
Anthony: What is the hottest encounter you've ever had? What's this I hear about sex clubs? Sorry, I like stalking you?
Cody: Hottest encounter I've had? Unsure if I have a single encounter that takes the cake here, but I have a few fuck buddies whose virginity I've taken, and with my dick that's quite an accomplishment. Also had a few stand-out kinky encounters before, as well. But nothing comes to mind as the absolute best encounter.The NY Bondage Club, while technically a sex club, I generally like to think of it as a place where I can tie people up all night long. I took my first steps into hardcore bondage there and have been going ever since. Great place to learn new skills. Always walk out of there with something new, plus 6 hours of tying guys up is great practice for perfecting ties and for experimenting with new rope work. Some of my favorite doms I met there and always love playing around with them.
Anthony: Is porn a long-time career choice for you or do you have other plans? What are some of your other hobbies and interests? Notice I'm just trying to get to know everything about you because this is like a blind date for me :)
Cody: Porn is a way to pay for school and rent. I'm studying computer engineering as an undergrad to continue to study for patent law. So I could continue with porn but my primary goal is to pursue an engineering or law career. As far as interests and hobbies, anything from movies, computers, hiking, cooking (I am a pretty damn great chief, from what people tell me), exercising, skydiving, scuba diving, discussion/debate, paintball, wrestling, clubbing, hanging out, cuddling, fucking :P , I just like being around people and doing stuff. I'm a rather relaxed and open person so I kind of go with the flow, so to speak. But I do try to help people when I can; if a friend is in need and they call me, I will help them. Also my word is binding, if I tell someone I will do something for them I will do everything in my power to do that.
Anthony: What separates you form the other cock-hungry porn stars in the biz? What is one word that describes you as a performer?
Cody: What separates me? Honestly I don't really know. My dick is on the large side of things but this is porn so there's always bigger. I am going to school to pursue a career, though I know many porn stars who have successful careers or who go to school while doing porn on the side. As a performer I think that the real defining thing that separates me is that I'm a great top with a great dick for topping but have almost exclusively bottomed on camera so far. And I do hope that this defining characteristic changes soon, as I really look forward to some great topping scenes. Oh, and I guess that I can suck and fuck myself... that's a little defining as well :P
And one word that describes me as a performer, versatile. Because I can top, bottom, dom, sub, self fuck, self-suck, do rope bondage, role play with different headspaces, etc. Sexually speaking, you name it and I can probably do it.


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The Institute for Environmental Studies (Instituut voor Milieuvraagstukken, IVM) is an interdisciplinary research institute at VU University Amsterdam that sits within the Faculty of Earth and Life Sciences (FALW). We closely cooperate with colleagues from ecology and geography in research and teaching programs.
IVM facilitates three main departments: Environmental Economics, Environmental Policy Analysis and Water and Climate Risk. The two other departments are Chemistry and Biology and Environmental Geography. All departments are located on the VU campus.


text:
Public Accessibility
-- Hold six town hall meetings, phone forums, and/or web-based meetings per year.
-- Publish personal email and cell phone for direct contact.
Transparent Actions and Votes
-- Post all voice and recorded votes on Facebook and website.
-- Maintain YouTube channel of speeches, debates, and State House video that can be accessed directly and/or via Twitter, Facebook and website.
Length of Service
-- Pledge to only run for re-election if service and votes reflect campaign positions.
-- Urge voters to elect someone new in two years if service and votes don't reflect campaign positions.
-- Pledge to self term limit -- 8 years maximum.
Source: http://www.sherifew.com/issues.php


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But, I have struggled since then with styling. I think they would go best with leggings and a flowy tunic....but I cannot wear that to work. Here is what I did...but honestly, these pants are a little big right now (good problem) and between that and this duster, I look bigger than I am...so I don't want that!
Oct 13, 2012
What Would You Do?
But, I have struggled since then with styling. I think they would go best with leggings and a flowy tunic....but I cannot wear that to work. Here is what I did...but honestly, these pants are a little big right now (good problem) and between that and this duster, I look bigger than I am...so I don't want that!
17 comments:
i would try tights and a skirtReplyDelete
i think that is work appropriate
such cute shoes and they look so comfy
Like you I often fall in love with the craziest cute things, and then have no idea how to wear them. I think they would be nice with Capri pants, or a skirt, or any outfit where you'd wear flats. I'd keep the rest of the outfit simple so the shoes really stand out, but mostly I'd just wear them!ReplyDelete
Great ideas so I won't add any. However, it is time to let the pants go - congrats on losing the inches!ReplyDelete
Try a basic black dress with some jazzy accessories.ReplyDelete
OR... skinny jeans/pants with a fun striped shirt and the duster?ReplyDelete
I can see these with a sun dress or a lounging outfit. (I just want to say, you look like you are losing weight--what are you doing? Time to DUMP the clothes that don't fit and embrace the new you!)ReplyDelete
Dark denim slim fitting (but not legging tight( jeans and a mustard cardigan like that color this is so popular this fall. I saw lots of them at Catos.ReplyDelete
- AnonymousOctober 13, 2012 at 2:53 PM
First.....DO NOT EVER WEAR CLOTHES THAT ARE TOO BIG AND FLOWY!!! Those pants have either got to be altered or given away. Now for those shoes.....Be careful about wearing too much black with the shoes or you will have the bumblebee effect. For me these are going-out shoes, not work shoes....lunch with the girls on Saturday, brunch on Sunday or I'm having Friday night drinks with friends. Wear them with slim capris or ankle pants, nothing longer and not black, try a dark burgundy or navy. Dark slim-legged denim rolled with a cuff. A white tunic belted blouse with three-quartered length sleeves. No scarf, you don't want too much going on at the top and bottom, finish with a gold cuff. Remember you are the star and the shoes are the fashionista touch.ReplyDelete
How about with a short black skirt and a yellow tweed Chanel style jacket over a cream blouse?ReplyDelete
I'm in the tights and skirt camp: both black, with a white blouse to lighten things up. Gold jewelry, but keep it simple.ReplyDelete
What about with the 'Wearing Autumn Spices' outfitfrom 9/12/12ReplyDelete
- AnonymousOctober 13, 2012 at 9:15 PM
The pants-maybe the entire outfit from casual Friday. Problem is width of pants. Deep six.ReplyDeleteReplies
The dark colors make you look tall and slender, not bigger at all. Fun shoes!Delete
Sorry not to be more positive but the two general themes here, that the pants need to be banished and that with black tights you risk looking like a bumble-bee are right-on.ReplyDelete
I think these shoes are spring/summer shoes and should be held back for wearing with a flowery skirt or dress and nude stockings or bare legs.
Thanks to everyone...do not worry about negative comments on this one...I asked for it! I appreciate your advice and hearing that I need to ditch the pants because they are too baggy...just makes me smile!!! Thanks to all of you!!ReplyDelete
They are ADORABLE!! I would wear them with a black skirt, white blouse, black/white jacket with a yellow scarf and yellow bangles. I would wear nude ot off black hose (nothing too heavy or dark.ReplyDelete
Thanks so much for joining in our conversation today! I appreciate your time and love hearing from you!


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MainStreetChamber Sugar Land Network Mixer
Rod White
Tuesday, April 22, 2014 from 6:00 PM to 8:00 PM (CDT)
Who's Going
San Francisco, California
London, United Kingdom
Florence, Italy
Event Details
MainStreetChamber Sugar Land is where Small Business Owners, Entrepreneurs and other Business Professionals come together to network, share resources and to help each other grow our businesses.
MainStreetChamber's motto is "Give First and ask nothing in return!" To that end, entry to the event as is membership to the Chamber is free... Every member receives a "Lifetime Free Membership Certificate."
This month's host is Tucano's Brazilian Grille in the First Colony Mall area! Appetizers are provided and there will be a "Cash Bar."
Tucano's has a fantastic menu and I urge everyone to stay after the networking event and dine with them in order to show our appreciation for their hospitality!
As always there will be door prizes and a lot of networking! I look forward to seeing everyone on Tuesday!
When & Where
Tucanos Brazilian Grill
16535 Southwest Fwy
Sugar Land,
Tuesday, April 22, 2014 from 6:00 PM to 8:00 PM (CDT)
Add to my calendar
Rod White
Our Mission Statement
MainStreetChamber™ fosters leadership by developing and engaging a wide network of business professionals.
MainStreetChamber™ forges strategic alliances with companies that offer relevant products and services for small business growth and profitability; each extending a negotiated discount to our members.
MainStreetChamber™ is a support system for small business owners, encourages member to member business and gives back to our community by the group involvement with local charities and non-profit organizations.
MainStreetChamber™ is a service oriented organization and encourages community involvement. We support multiple national non-profit organizations as well as many local non-profit organizations through the participation of members in each Chapter.
A successful leader is a visionary with a solid work ethic able to access multiple resources. MainStreetChamber™ offers an abundance of resources that provide members with the tools necessary for successful growth and profitability.
Our Vision
In uncertain economic times so many organizations are problem focused, belaboring the frustration of ever tightening markets.MainStreetChamber™ is solution oriented, we help our members face problems and turn them into opportunities for growth and profit. We are redefining business and positioning ourselves through leadership and diversification; to not only make it during tough times, but to be poised for profit in the near future.


text:
- Duration
Half a day.
- Group Size
Minimum of 6 hens.
- Availability
7 days per week.
- Seasonal
All year round.
- Dress Code
Outdoor clothes, sturdy footwear.
- Location
18 miles from the town centre.
Please note...
Please Note: This page provides a general guide to our hen activity day in Bournemouth. We work with multiple suppliers, so please be aware that specifics may vary. Feel free to ask your Destination Specialist at the time of booking if you have any questions about this.


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POLICE have questioned a "person of interest" into the disappearance of horse-lover Leisl Smith, prompting an excavation of properties on the state's Central Coast yesterday for her remains.
A source has told The Daily Telegraph several properties in the Tuggerah area and also further north in Gloucester were scoured.
A person is believed to have been interviewed at length by detectives at Wyong Police Station. Ms Smith went missing on August 19 last year after leaving her Wallarah home by car at 1pm.
Concerned family members informed police of Ms Smith's disappearance when she failed to return home and police have been involved in an extensive search ever since.
Her car, a silver Honda Accord, was found abandoned at Tuggerah train station on September 26. Initial investigations revealed Ms Smith's mobile phone was used in the days after her disappearance but it appears she did not access her bank account or seek medical assistance.
Police are treating the disappearance as suspicious.
At the time, Ms Smith's parents expressed disbelief that their daughter would leave her horse Molly who was due to give birth to a foal.
The latest development in the investigation comes just hours after Ms Smith's parents posted on a Facebook page devoted to her: "My friends, we need you, now more than ever, someone must know something."
Their daughter would have turned 24 on Tuesday.
Friends again took to social media to send her birthday greetings over the weekend.
Jenni Lind wrote: "Happy birthday Leisl. May you be safe wherever you are."
Donella Waters said: "Happy Birthday Leisl. My wish is that you are safe and you can somehow get a message to your loved ones to put them at ease."
Friends and family have posted photos of Ms Smith, painting her as a friendly family-orientated young woman who loved animals.
Strike Force WEHL was set up late last year to investigate her disappearance. Tuggerah Lakes Local Area Command crime manager Detective Inspector Dave Waddell said the disappearance was "very out of character".
"Leisl is an animal lover and her horse gave birth in late August. The fact she missed the event is worrying."
Originally published as Little hope remains for Leisl


text:
About the Book
Tony Witt and Jessica Thompson married August 4, 2007 leading a Zumba group on cruise. Together they created Amore Dance Studio in Kansas City and qualitfied as the first independent Zumba licensors in the US. When Tony and Jessica returned from the cruise they held a large wedding reception in The Madrid Theater in Kansas City for all their friends, family and fellow dancers in KC. This is their reception party.
Features & Details
- Category Entertainment
Standard Landscape, 10×8 in, 25×20 cm
20 Pages
- Publish Date Aug 18, 2007
- Tags Jessica Thompson, Jessica Witt, Kansas City, Tony Witt, amore dance studio, madrid theater, social dance, ballroom, dance, salsa, zumba
About the Creator
I date my photography from 1967 when I took a summer course at the University of Nebraska. Cameras have been with me ever since, regardless of the job, sometimes fully in photography or using photography. Ballroom dancing, starting in 1994 brought me into dance photography until today almost all my photography is dance. I shoot either stills or video of a number of dance companies in the KC area and (since 1997) keep a calendar of events, lessons, dances, concerts on my KCDance.com website. KCDance also (no surprise) has extensive pictures of dance in KC as well as data on dance companies, studios, instructors and more, offering a free database where dancers/studios may enter their own calendar information.
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The second half of the name misleads because the menu sails far from Shanghai. But the "Evergreen" part is right on; the place is reliable and consistent. Dishes arrive speedily, and the flavors are as straightforward as the decor. Still, a mapo tofu stew deftly balances the tofu's smoothness with a bite of chili oil and black pepper. The kitchen can be heavy-handed with oil, particularly in a gluten stir-fry that nonetheless retains the sweet crunch of its cucumberlike loofah (a.k.a. the bath sponge). Gingery Lion's Head meatballs and a ginger-scallion sablefish will be better if you ask your waiter to curb the oil. Eight Jewel sticky rice, topped with roasted pumpkin seeds, is a nice cap to the meal.
|Venue name:
|Evergreen Shanghai
10 E 38th St
New York
|Cross street:
|between Fifth and Madison Aves
|Opening hours:
|Mon–Fri 11am–10pm; Sat 11:30am–10pm
|Subway: B, D, F, V to 42nd St–Bryant Park; 7 to Fifth Ave
|Average main course: $13. AmEx, MC, V
|Do you own this business?
To improve this listing email: firstname.lastname@example.com


text:
Test Center Administrator ( 2 - 12 yrs)
Ably Talent Management
RS 50,000 To 2,00,000 Chittoor, Eluru, Guntur, Kurnool, Nellore, Ongole, Rajahmundry, Srikakulam, Tirupati, Vijayawada, Visakhapatnam, Vizianagaram, Anantapur
Job Responsibilities:- * Conducting online exam at the specified center as per prescribed procedure & ensure all procedure are strictly adhered to. * Reporting of daily activities in the given format * Timely escalation to HO for critical and ab...
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Sawasdee Hotel Chiang Mai Thailand
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A Controller Directs and Coordinates a Company's Financial Planning and Budget Management Functions and Oversees the Financial Management of Foreign Operations. He is Responsible for Profitability Analysis, for Contract Negotiations and Product Inv...
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Taking care of after sale in network locations Responsible planning and execution of activities in the command area. 20nos team to be handled.
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Test Centre Administrator for the online examination. ( 0 - 1 yrs)
Ably Talent Management
RS Up To 50000 Chittoor, Eluru, Guntur, Nellore, Ongole, Rajahmundry, Srikakulam, Tirupati, Vijayawada, Visakhapatnam, Vizianagaram, Kadachira, Kannur, Anantapur
Urgently Require Test Centre Administrator for the Online Examination. 14/08/2016 - 15/08/2016 work Location as Below for Andhra Pradesh,Telangana *east Godavari - Rajamundry *prakasam *vizag *srikakulam *vizianagaram *nellore *ongole *anan...
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Computer Operator ( 0 - 1 yrs)
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RS 80,000 To 2,00,000 Adilabad, Akkarampalle, Akkayapalle, Alwal, Amadalavalasa, Amalapuram, Anakapalle, Asifabad, Guntur, Kurnool, Medak, Tirupati, Vijayawada, Visakhapatnam, Along, Itanagar, Anantapur
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So what is bringing people here in their droves? My little family and I headed over for lunch this week to find out for ourselves.
Unfortunately Sophia had been suffering with reflux that morning, leading to bouts of crying, spitting up and inevitable outfit changes. As a result we were considerably late for our reservation - almost an hour in fact, something that I really dislike and try to avoid as much as possible. It was relief that we opened the door to be greeted with warm smiles from our waitress, told that they were waiting for us and taken to a table which they had kept waiting. I was reminded that the relaxed, friendly and attentive service which we'd also experienced on previous visits really gives this place the edge.
The unconventional decor of the Victorian-era themed interior makes it stand out amongst some of the more traditional restaurants on the island. The colourful interiors, adorned with ornate oil paintings, empty gilt frames and old fashioned light fixtures make it one of the most Instagram-able spaces on The Pearl.
We started with warm, gooey and satisfying Mozzarella sticks.
And the restaurant's famous Piri Piri Prawns which had a sharp tang of spice, and were served with crispy potato croquettes that take the edge off the heat. I was happy to discover that this dish was every bit as moreish as I'd heard it was.
My breakfast-obsessed husband opted for Eggs Benedict for his main course, while I fancied going for something a little healthier, and chose the Quinoa Salad with grilled chicken. We knew the Benny was a good one, as we had trotted down here for breakfast on numerous occasions previously.
Look at that perfect yolk!
However, the quinoa salad was a new one to me, and I was rather taken aback when this mammoth plate of food was placed on the table in front of me!
Tasty, perfectly-cooked quinoa spilled out of a flakey pastry bowl, accompanied by chickpeas, pomegranate seeds and other more traditional salad items in a delicious dressing. The grilled chicken was juicy and cooked to perfection. The only downside was that there was enough on the plate to feed a family of five and I was only able to manage about half it!
By the time the dessert menu was brought out, we were both stuffed, but agreed to order the strawberry cheesecake to share.
Definitely one of the creamiest and tastiest cheesecakes I've had in Doha so far!
We had had a lovely meal, we had warded off any FOMO by ordering several different styles of cuisine from the extensive menu, and most importantly, we were full to the brim.
In fact, we had had such a good time that we returned the very next day for a drink on the terrace.
If you are looking for a relaxed, friendly and informal place to eat, and if you are one of those people who dislikes the confines of small, a la carte menus and prefers to be spoilt for choice when it comes to their food, then this is the restaurant for you.
We were guests of Shakespeare & Co. on this occasion, but as always all views are my own.


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(Fan created content. Distinct from hoaxes and parodies)
(Fan created content. Distinct from hoaxes and parodies)
Type of website
Blog, Discussion, Theories, Spoilers
Date Launched
Date Ended
DoTeeVee is a UK based fan site for 25 various shows which started up early 2009. The site is based on other fan sites such as Oliv3r and DarkUFO. It takes the format of a forum and includes sections for discussion and fan speculation.
Shows included on the site
- 24
- Battlestar Galactica
- Bones
- Desperate Housewives
- Dexter
- Doctor Who
- Family Guy
- Fringe
- Greys Anatomy
- Heroes
- House
- Jericho
- Lost
- My Name is Earl
- Nip Tuck
- Prison Break
- Scrubs
- Skins
- Smallville
- South Park
- Stargate Atlantis
- Supernatural
- Top Gear
- Ugly Betty
Page Info
Editing in progress
See also
- DarkUFO Another site providing similar content
- Kristin Dos Santos, a well known mainstream Lost blogger (from E! Online)
- DocArzt, a well known Lost blogger
- Michael Ausiello, a well known Lost blogger


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Joe is Donna's husband who was first introduced as her ex-boyfriend in the episode "One in 8,000". Joe is a school music teacher. They were married in the year 2017 in the episode "Donna & Joe".
Season 6 Edit
Joe first appeared in "One in 8,000" when Donna agrees to help Ron volunteer at the local elementary school. Donna tells Ron to keep her ex away from her, telling Ron that she doesn't like who she becomes when she's around Joe.
While at the school, Joe warmly greets Donna, who rebuffs him. Ron keeps an eye on Joe throughout the day and realizes that he is a genuinely kind and compassionate person. After Joe appears to share Ron's love of woodworking, Ron tells Donna to give Joe a second chance. Donna tells Ron that Joe is too boring for her, to which Ron tells her not to "confuse drama with happiness." Donna asks Joe out at the end of the episode.
Season 7 Edit
In "2017" Donna reveals to Leslie that she and Joe are engaged. In "Save JJ's", Joe and Donna are seen tasting wedding cakes at Tom's Bistro.
The two marry in "Donna and Joe".


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We're Hiring! Greenwich, CT: NOW is the BEST time to join Stella & Dot!
Zandra Gay, LimeLight by Alcone
Wednesday, November 30, 2016 from 10:00 AM to 12:00 PM (EST)
I'm hiring! Join Stella & Dot Founding Executive Director Zandra Gay to hear more about why NOW is the best time to be a stylist! Come see what all the buzz is about! You'll want to hear why NOW IS A GREAT TIME to join this booming company called STELLA & DOT and how YOU can work from home!
Let's talk business, passion, flexibility and fabulous rewards! Grab a girlfriend and bring her along ALL WELCOME! With the launch of our brand new Holiday 2016 Collection, the time has never been better to join! Whether you're seeking a part-time or full-time opportunity, our business model allows you to grow your business at your pace, and in your own way. Stella & Dot is much more than technology and fashion: we are a people company inspired by and created for strong women, just like you.
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Meryl Streep & Kevin Kline Reunite in ROMEO & JULIET for The Public Theater's 50th Anniversary Gala, 6/18
In honor and celebration of the 50th Anniversary of Shakespeare in the Park at the Delacorte Theater, The Public Theater will hold a special one-night-only gala event on Monday, June 18, featuring Kevin Kline as Romeo and Meryl Streep as Juliet in a star-studded staged reading of ROMEO AND JULIET, directed by Daniel Sullivan.
The Delacorte Theater in Central Park officially opened on June 18, 1962 with a production of The Merchant of Venice, directed by Public Theater founder Joe Papp and Gladys Vaughn and featuring the then-unknown actors George C. Scott and James Earl Jones. Conceived by Papp as a way to make great theater accessible to all, over the past 50 years more than five million people have enjoyed more than 100 free productions of Shakespeare and other classical works and musicals at the Delacorte.
At The Public Theater's Anniversary Gala on June 18, Tony Award winner Al Pacino will be honored for his body of work with The Public Theater, going back to the early 1970s and including his acclaimed performance as Shylock in the Shakespeare in the Park production of The Merchant of Venice in 2010. The unforgettable evening in Central Park will include dinner al fresco, the staged reading of ROMEO AND JULIET, and a party immediately following the performance. The benefit event is being chaired by Public Theater Board Members Arielle Tepper Madover and Alexandra Shiva.
"For 50 years the Delacorte Theater has been home to the greatest American actors, who have been able to hone their artistry in the most beautiful, democratic theater in the world. Romeo and Juliet will be a celebration of those actors, a joyous love letter to the Delacorte, to Central Park and to New York City," said Artistic Director Oskar Eustis. "Meryl is the greatest actress of our age, and Kevin is America's preeminent Shakespearean. Their partnership, which has stretched over 30 years, has provided some of the most incandescent moments in our dramatic history. This unforgettable evening will be a spectacular addition to that history and a perfect way to celebrate 50 years of Shakespeare in the Park at the Delacorte. It will also give us the breathtaking chance to see Meryl and Kevin play the Balcony scene."
ROMEO AND JULIET is one of the great love stories of all time. The tragic story of two young romantics star-crossed by family pressures and a society that values status above all else, ROMEO AND JULIET's passion and sweep make it the perfect play for a moonlit Central Park night. The Public Theater has produced this beloved play only twice before at the Delacorte (1968 and 2007). Now Meryl Streep, who has performed five times at the Delacorte since 1976, and Kevin Kline, who has performed nine times since 1970, will assay these roles for the first time in their careers and celebrate the priceless gift of Shakespeare in the Park to the people of New York.
Tickets for The Public Theater's Anniversary Gala on Monday, June 18 begin at $1,500. For more information, please call (212) 539-8547 or visit www.publictheater.org.
THE DELACORTE THEATER officially opened in Central Park on June 18, 1962 with The Merchant of Venice, directed by Joseph Papp and Gladys Vaughan and featuring George C. Scott as Shylock. The Merchant of Venice was followed that summer by a production of The Tempest, directed by Gerald Freedman and featuring Paul Stevens as Prospero and James Earl Jones as Caliban. The first Delacorte summer season concluded with King Lear, directed by Joseph Papp and Gladys Vaughan and featuring Frank Silvera as Lear. Since that time more than 100 productions have been presented for free at the Delacorte Theater. Highlights of past productions include Othello in 1964 with James Earl Jones; Hamlet in 1975 with Sam Waterston; The Taming of the Shrew in 1978 with Raul Julia and Meryl Streep; The Pirates of Penzance in 1980 with Kevin Kline and Linda Ronstadt; Henry V in 1984 with Kevin Kline; Much Ado About Nothing in 1988 with Kevin Kline and Blythe Danner; Richard III in 1990 with Denzel Washington; Othello in 1991 with Raul Julia and Christopher Walken; The Tempest in 1995 with Patrick Stewart; The Seagull in 2001 with Natalie Portman, Meryl Streep, Kevin Kline and Philip Seymour Hoffman; Mother Courage in 2006 with Meryl Streep and Kevin Kline; Macbeth in 2006 with Liev Schreiber; HAIR in 2008 with Jonathan Groff and Will Swenson; Twelfth Night in 2009 with Anne Hathaway; The Merchant of Venice in 2010 with Al Pacino and Lily Rabe; and most recently last summer's acclaimed productions of All's Well That Ends Well and Measure for Measure.


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Sunday, March 22, 2015
Repairing Damaged Photos with Photoshop
2:29 PM | Posted by Laura Lou | | Edit Post
First I scanned each piece separately. With the document, it was sent to me all in one scan with spaces between the pieces.
I moved the separate pieces onto a document in Photoshop. I use adobe Photoshop Creative Suite 4. The steps wouldn't be much different for other versions of Photoshop Elements or Creative Suite. Using the lasso tool I removed the white around each photo piece. Then I aligned the pieces to each other.
Then you can scrap or not as you want. I chose NOT to use filters to make the differences in tone blend in. I wanted the aged look. I tried to fix the groom's mouth but there wasn't enough there to duplicate and other things I tried looked bad. I think he may have had a light mustache, but this wasn't my family and I didn't know.
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About Me
- Laura Lou
- I am a retired Middle School Science teacher from Michigan spending 4 months each winter in Florida and learning about a whole new world.
Blog Archive
My Blog List
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Forty Years of Scrapping
Long before it was popular, I was trying to decorate arrangements of photos and sentimental items. Here I want to share some of my personal history and more important, some ideas I have gleaned from more than 40 years of scrapping.
My Other Blogs
- http://scapethattable.blogspot.com/
- My Snowbird Wildlife Blog
- Musings of a Genealogy Nut
- Gammy's Stories
- A Mother's Legacy


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All Android applications categories
All your favorite quotes and sounds from Doctor Evil from the movie Austin Powers, AD-FREE! For fans of the movie and Mike Myers.
************In the Premium version, save quotes & sounds to your phone and use as ringtones, notifications or alarms (in-app upgrade)! ***************
NOTE: This soundboard is an unofficial, fan-made app. All trademarks and content are property of their relative owners.
Tags: dr evil soundbourd not fillted , dr. evil soundboard , mr evil soundboard
from 1 reviews
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Ford Shelby Mustang for Sale
Selected Filters:Type of Ad: Vehicles for Sale Make: Ford Model: Shelby Mustang Remove All
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If you wanted 500 plus horsepower from the factory, one used to need to pony up to a Lamborghini or Ferrari or turn to... More
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5-Panel Fridays: HALL OF FAME "Broken Bones Trucker" 5-Panel Cap
Posted by VinReigns, July 19th, 2013 12:07 am under 5 Panel
HALL OF FAME brand puts a new spin on the 5-Panel genre. The shape is the same but instead of cotton or wool material, they used a plastic mesh trucker style material for the entire crown. This "Broken Bones" cap is a light navy blue with an oval patch sewn on the front panel. The patch has a yellow background with "BROKEN BONE CLUB, HALL OF FAME LTD." embroidered in blue. The blue outlined bone in the middle is broken right in half.


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Today, a radio show asked the question, "Where does the dentist live in Finding Nemo?" I called in and got through. When he asked me the question, instead of the actual answer I quickly gave out my own address over live radio. FML
MobilityYou are connected to FML via the mobile site or an app. How modern.
Consolation prizeYour FML was denied. We had to at least give you a badge to cheer you up a bit.
Up and coming moderatorIt's nice of you to help us sort out the submissions, using FML's moderate feature.
Keen reader – Level: godlike ninjaYou have voted for 100% of the entire collection of FMLs to date.0%
Keen reader – Level: master ninjaYou have voted for 50% of the entire collection of FMLs to date.0%
Keen reader – Level: student ninjaYou have voted for 15% of the entire collection of FMLs to date.1%
The return of the thumbYou have thumbed 5000 comments.0%
The thumb strikes backYou have left your thumbprint on 2500 comments.0%
A new thumbYou've used your thumb on 1000 comments.1%
I agree, my mouse works.200 "I agree" votes is a good start.9%
YDI MasterYou made your 500th "You deserved it" vote.3%
JudgmentalYou have voted "You deserved it" over 100 times.14%
50 favoritesLove knows no boundaries. You've already added 50 FMLs to your favourites list!10%
One more and it's business timeYou've received 68 Hugs on your profile. Kinky.0%
Today, my dad came into my room, looked at my laptop, and said he could hear the porn I was watching all the way from his room. I wasn't watching porn. We soon realised it was actually coming from his mobile phone. FML
Today, I walked into the living room to find my 11-year-old daughter about to kiss her "not my boyfriend" on the lips. When I asked what she thought she was doing, she peeled a piece of scotch tape off her lips and said, "It's okay! We're using protection." FML
Today, I went out to a restaurant to meet a girl that I met online. When I arrived I texted her and she said she was wearing a blue shirt. The only person that was wearing anything blue was a fat man smiling in the corner. FML
Today, my parents booked my 18th birthday party at Chuck E Cheese's. FML


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The hotel sits grandly on the dramatic shoreline of the Indian Ocean overlooking the iconic lighthouse of Umhlanga. Features range from the exceptional cuisine to the impeccable wines, a rich collection of artwork and furnishings, exquisite detailing in design and d�cor, to breathtaking ocean views throughout the hotel. This air-conditioned establishment offers a lobby, conference facilities and WLAN Internet access.
Perfectly situated on the ocean's edge, a brief 5-minute walk from Umhlanga Village Centre, the hotel is conveniently located for quick and easy access to Durban city centre, the international airport and numerous stylish shopping centres, yet has a feeling of classical charm and elegance like nowhere else on earth.
With 86 beautifully appointed rooms and suites, the range of accommodation options will suit the needs of every guest, from individuals, to honeymoon couples and families. Children are welcome, with special facilities and a holiday club available. Rooms feature an en suite bathroom with hairdryer, a king-size bed, satellite/cable TV, Internet access, tea and coffee making facilities, air conditioning and a balcony or terrace.
The hotel features an exquisitely designed spa. The nearby beach is sandy.
American Express, Diners Club, MasterCard and VISA are accepted as methods of payment.
The hotel is perfect for personal retreats, private meetings and celebrations. Leading practices in eco-tourism have been incorporated to create a truly environmentally respectful hotel.
Room Facilities:
Satellite cable TV
Internet access
Tea Coffee
Double bed
King size bed
Central airconditioned


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Let us know when your receive great advice so we can thank our lawyers and point others with similar questions in the right direction.Got it!
background my husband was a heavy drug user when he got all his cases long rap sheet in 02 THEFT BY RECEIVING STOLEN PROPERTY, UNAUTH USE AUTO AND OTHER VEHICLES, CRIMINAL CONSPIRACY, in 06Int Poss Contr Subst By Per Not Reg for this he got probation for 12-24 months did not report also in 07 Theft By Unlaw Taking-Movable Prop, Receiving Stolen Property, Poss Instrument Of Crime W/Int, Unauth Use Motor/Other Vehicles now on May 29,13 got stopped for running a red light was incarcerated for 2 warrents warrents were lifted but has 2 detainers holding him has changed his life around 5 1/2 years clean& sober, mentors youth helps at a food bank got married, business license totally different person got court on july 22nd&24th what's the best and worst case scenario for these charges?
The best thing you can do for your husband is to immediately retain an experienced criminal defense attorney. The attorney will visit with your husband, become familiar with the cases and have him released from prison as soon as possible. Most firms, like ours, provide a free consult.Ask a similar question
The outcome of the two cases in which there was probation violations will be determined by the judge considering several facts. That he is doing well is impressive, but he still needs to answer to the violations at his Gagnon Hearing. He could get time-served, further probation or a new sentence for jail time. Hire counsel immediately or have the public defenders represent him. He will need counsel.Ask a similar question
I agree with my colleagues. Your husband needs an experienced criminal attorney. If you cannot afford to hire one, he should apply to the public defender's office. Do not attempt to do this on your own. Good luck!Ask a similar question
Your husband has a lot going for him, but the PO is just going to treat him as another name on a folder unless his case is presented to the PO effectively. He will get a more favorable review by the PO and the court. He shouldn't go it alone.Ask a similar question
thank you went to court for the 06and 07 cases they were put together in front of one judge here's the update the DA had dropped the feloney3 charges so my husband only pleaded guilty to a misdemeanor at first he got 9months in with immediate parole and 12 months probation after hearing our pastor speak on his behalf he only gave him 12 months probation very happy with the outcome however he is till in custody has one more detainer from 02 case the lawyer said he doesn't see this lawyer giving him any time still praying and keeping my fingers crossed
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Welcome to Americas Best Value Inn of St. Joseph, the largest city in northwest Missouri. Born of the fur trade and one of the last stops before pioneers hit the roughest stretches of their journey, St. Joseph has a storied history full of outlaws including Jesse James, who finally met his demise here. As the place where the Pony Express began, Missouri recalls a time when the West was truly wild. The Jesse James Museum, Pony Express Museum, St. Joseph Museums, and St. Joseph Fire Museum are all within four miles of our. We are less than three miles from Vatterott College and Missouri Western State University. Denny's, AppelBee'a & Carlos o Kelly's Restaurant, Whiskey Creek, and Red Lobster are within walking distance of our interior corridor hotel.
Our St. Joseph hotel offers clean comfortable guest rooms, affordable rates, and an attentive 24-hour front desk staff. Start your day right with our free deluxe continental breakfast, served daily from 5:30 am to 9:30 am. Stay connected with free wireless high-speed Internet access available throughout our hotel and guest rooms. Appreciate the convenience of our on-site coin operated guest laundry facility and business center. Step into the privacy of your own guest room and experience absolute relaxation. Room amenities include a microwave, mini-fridge, coffeemaker, 39 inch flat TV , HBO, hairdryer, iron, and ironing board,and free local calls. German Shepherds and Boxers are not allowed.
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Free public parking is available on site (reservation is needed).
Free Wi-Fi is available in all areas and is free of charge.


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Glorious Trebizond
- The Empire of Trebizond, very small and diplomatically isolated, reforms an alliance with Georgia to its east and strengthens its relations through a royal marriage.
- The Khaganate of Ak Koyunlu annexes the minor Anatolian state of Erzincan. Trebizond is now wedged uncomfortably between Georgia, Ak Koyunlu, and the expanding Ottoman Empire.
- The Empire of Trebizond passes a 'Free Market' policy on trade to encourage merchants.
- The Khaganate of Ak Koyunlu breaks off its alliance with the Jalayirids.
- A civil war in the Ottoman Empire causes it to break apart.
- Georgia and the Byzantine Empire both agree to recognize Trebizond's sovereignty and will come to its aid should it be threatened.
- Manuel III, the Trapezuntine emperor, hires Turkish and Norman mercenaries and invades the neighboring Islamic state of Candaroğlu. The Trebizond Greeks force many of the Muslim forces to retreat towards the capital, while cutting off Sinope from the rest of the nation.
- The Khaganate of Ak Koyunlu and the Emirate of Karaman both declare war on Trebizond. The Byzantine Empire and Georgia both send troops to aid in repulsing the subsequent invasion.
- Georgia invades the Khaganate of Ak Koyunlu, annexing several provinces. Meanwhile, a Greek army pushes them out of Trebizond. Soundly defeated, they are forced to seek peace. In order to reduce and better divide the khaganate, the Georgians demand that they release Armenia as a sovereign state. The Kingdom of Armenia is thus reformed.
- After a 260-day siege, Trebizond captures Sinope from Candaroğlu. The Trapezuntine forces then pour into Kastamon, forcing Candaroğlu to sue for peace. They are soon forced to pay a heavy tribute to the Empire of Trebizond and surrender all the territory around Sinope.
- The expanding Kingdom of Cyprus comes into conflict with Georgia, breaking into all-out war.
- Manuel IV becomes emperor of Trebizond as the newest Megas Komnenos. He subsequently declares war on Cyprus to aid Georgia.
- The Ottoman Empire becomes mainly united again under its latest sultan, but most of its Anatolian provinces have broken off into separate Turkish states.
- Sensing Turkish weakness, the Byzantines push north from Morea and conquer Athens.
- The Khaganate of Ak Koyunlu attacks the new Kingdom of Armenia, causing Georgia and Trebizond to come to its aid. In response, the Najd tribes and the Golden Horde, Ak Koyunlu's two allies, refuse to come to its aid.
- A Turkish revolt occurs around Sinope after they are mistreated by Trebizond officials. The rebellion is appeased by Manuel IV, who promises to look into the matter at once.
- The Trapezuntine forces invade the Khaganate of Ak Koyunlu and seize the province of Erserum.
- The Khaganate of Ak Koyunlu accepts peace with Georgia and Trebizond by agreeing to renounce its claims on the Kingdom of Armenia.
- A French naval expedition lands in Sinope and begins to mistreat the local Sunni population. The Empire of Trebizond retaliates and decisively defeats the tiny French force. All across Pontus, the Greeks hail this as a major victory.
- The Turks of Sivas in Asia Minor break free from the Timurids and declare their independence. However, their southernmost provinces, towards Cilicia, are annexed by the Egyptian Mamluk sultanate.
- A major French fleet lands in Sinope, but the landing forces are repelled by Georgian and Trapezuntine armies.
- Manuel IV sues for peace with France, and agrees to pay a taxing tribute.
- The Empire of Trebizond demands full annexation of Candaroğlu. Unable to put up a credible resistance, Candaroğlu surrenders and is absorbed into Trebizond, which now controls a four-province empire.
- French forces, freed from Trebizond, concentrate in Georgia.
- Strengthened by the Silk Road, the Empire of Trebizond becomes the fifth richest nation in the known world. Manuel IV also begins production of copper, wine, and Naval supplies for sale to other nations.
- When Sultan Orkhan II of the Ottoman Empire regains control of his Anatolian provinces and begins to expand further east, the Mamluk Sultanate declares war on the Ottoman Turks.
- Georgia agrees to pay tribute to the French in return for France withdrawing its forces from Georgian territory.
- The Empire of Trebizond and the Mamluk Sultanate form a shaky alliance against the Ottoman Empire.
- The Golden Horde amasses numerous Mongol armies at Georgia's borders.
- The Ottoman Turks invade Mamluk territories in Anatolia.
- The Beylik of Dulkadir is absorbed into the Mamluk Sultanate.
- The King of Georgia wills his throne to Trebizond, but the king of Poland, who claims a distant relation to the Georgian ruling family, declares war on the Trapezuntine nation.
- The Empire of Trebizond launches an invasion of the Timurid domains.
- The Ottoman Empire is driven out of Mamluk territory, with the Turkish forces suffering heavy losses. While Georgia halts the Timurids from retaliating against Trebizond, Manuel IV leads an invasion of the Turks' Anatolian provinces.
- The Trebizond Greeks successfully drive the Ottomans from central Anatolia. Fierce fighting takes place around the region of Angora.
- A Timurid army amasses at the border of Trebizond, so Manuel IV withdraws half of his army and rushes to meet them on the eastern Pontic border.
- The Timurids retake control of Sivas, but are attacked by Trapezuntine and Georgian forces. They are soon crushed.
- Several Timurid hordes spill into the Khaganate of Ak Koyunlu.
- Athens is seized from the Byzantines by several French and Venetian dukes, who declare the resurrection of the Latin Duchy of Athens.
- The Empire of Trebizond negotiates a peace with the Ottoman Empire by forcing them to cede Bithynia.
- The Empire of Trebizond and Byzantium renew a military alliance.
- Georgia, with much difficulty, drives the Timurids from their territory.


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Skeletal muscle alterations and exercise performance decrease in erythropoietin-deficient mice: a comparative study
Erythropoietin (EPO) is known to improve exercise performance by increasing oxygen blood transport and thus inducing a higher maximum oxygen uptake (VO2max). Furthermore, treatment with (or overexpression of) EPO induces protective effects in several tissues, including the myocardium. However, it is not known whether EPO exerts this protective effect when present at physiological levels. Given that EPO receptors have been identified in skeletal muscle, we hypothesized that EPO may have a direct, protective effect on this tissue. Thus, the objectives of the present study were to confirm a decrease in exercise performance and highlight muscle transcriptome alterations in a murine EPO functional knock-out model (the EPO-d mouse).
We determined VO2max peak velocity and critical speed in exhaustive runs in 17 mice (9 EPO-d animals and 8 inbred controls), using treadmill enclosed in a metabolic chamber. Mice were sacrificed 24h after a last exhaustive treadmill exercise at critical speed. The tibialis anterior and soleus muscles were removed and total RNA was extracted for microarray gene expression analysis.
The EPO-d mice's hematocrit was about 50% lower than that of controls (p < 0.05) and their performance level was about 25% lower (p < 0.001). A total of 1583 genes exhibited significant changes in their expression levels. However, 68 genes were strongly up-regulated (normalized ratio > 1.4) and 115 were strongly down-regulated (normalized ratio < 0.80). The transcriptome data mining analysis showed that the exercise in the EPO-d mice induced muscle hypoxia, oxidative stress and proteolysis associated with energy pathway disruptions in glycolysis and mitochondrial oxidative phosphorylation.
Our results showed that the lack of functional EPO induced a decrease in the aerobic exercise capacity. This decrease was correlated with the hematocrit and reflecting poor oxygen supply to the muscles. The observed alterations in the muscle transcriptome suggest that physiological concentrations of EPO exert both direct and indirect muscle-protecting effects during exercise. However, the signaling pathway involved in these protective effects remains to be described in detail.
The hematopoietic effect of erythropoietin (EPO) is known to increase exercise performance by inducing a higher maximal oxygen uptake (VO2max) in athletes. This EPO cytokine is also used as a therapeutic in patients. Indeed, disease-associated, low levels of EPO lead to a drop in hematocrit (Htc), marked anemia and decreased exercise performance. Congestive heart failure (CHF) and chronic kidney failure (CKF) lead to progressive renal dysfunction and a decrease in EPO levels, with reduced erythrocyte production by bone marrow. Thus, reduced exercise capacity is a clinical hallmark in CHF and CKF patients, who typically show lower VO2max values than age-matched normal subjects. Indeed, as kidney function declines over time, there is a corresponding decline in exercise performance
Furthermore, it is now well accepted that EPO's biological activity is not restricted to regulation of erythropoiesis. In fact, EPO is a member of the cytokine superfamily and has significant homology with mediators of growth and inflammation. The EPO receptor (EPO-R) is also known to be present in heart, neuronal, retinal, renal and muscle tissues
However, it is not known whether physiological levels of EPO exert a protective role in skeletal muscles. In view of (i) the identification of EPO-R in muscle tissue and (ii) the known tissue-protective effects of EPO, we hypothesized that physiological levels of the cytokine may have protective effects on muscle.
Thus, we used a murine EPO functional knock-out model (the EPO-d mouse, based on EPO immunization) to decrease active circulating levels of EPO and thus investigate the loss of function's impact on exercise performance and on the muscle transcriptome. The EPO-d mice had a low Htc and so we expected them to have lower performance levels and more impaired muscle oxidative function than inbred, control mice. Hence, the objectives of the present study were to confirm a decrease in exercise performance and highlight muscle transcriptome alterations in a murine EPO functional knock-out model (the EPO-d mouse).
Ethical approval
All protocols were approved by our institution's Animal Care and Use Committee and complied with the Council of Europe's European Convention for the Protection of Vertebrate Animals Used for Experimental and Other Scientific Purposes.
The protein functional knock-out was obtained by immunoneutralization of circulating EPO, according to the vaccination method developed by Nokad®
A total of 17 adult female C57Bl6/J mice (9 EPO-d mice and 8 control inbred animals) were included in this study. They were ear–punched for identification. Male were excluded to avoid a potential gender effect.
The mice were five months old when they performed the exercise tests. The animals were kept in an animal facility (CERFE, Genopole, Evry, France) in a specific and opportunist pathogen-free environment and at a temperature of 22°C with 12h:12h light-dark cycles. The animals were supplied with water and food
Exercise protocols
The exercise testing protocol was performed on a single-lane motorized treadmill (Columbus Instruments, Columbus, OH) with an adjustable belt speed (0–99.9 m.min-1). The rear of the treadmill was equipped with a low-voltage, electric stimulating bar, to encourage each mouse to run. The bar was set to deliver 0.2 mA at a frequency of 0.25 Hz, which caused an uncomfortable shock but did not injure the animal.
Measurements and data recording
Oxygen consumption (VO2) was measured by means of a rapid-flow, open-circuit, indirect calorimeter. The single-lane test treadmill was placed in a metabolic chamber. Ambient air was fed through the chamber at a rate of 0.66 l.min-1; the flow was chosen such that the O2 difference across the chamber was within the sensor's range (-0.3 to -0.8% O2). A fan mixed the incoming air with the air around the treadmill and blew it towards the animal. The air flowed from the front of the treadmill to the rear and then returned under the belt towards the front. This created a rapid, circular "loop" of mixed gases (incoming "fresh" air and accumulated exhaled gases) from which a sample was drawn for analysis (the Oxymax from Columbus Instruments). Gas samples were taken every 5s and dried prior to measurement of the oxygen and carbon dioxide fractions.
The gas analyzers were calibrated with standardized gas mixtures (Air Products, Paris, France) before every test session, as recommended by the manufacturer. The treadmill test provided an estimate of VO2max, defined as the highest oxygen consumption attained over a 15-second period during the testing protocol. To allow rapid comparison over a wide range of body weights (and especially with human data), dimensional analysis and empirical studies show that VO2 should be expressed in relation to body mass raised to the power of 0.75.
The mice were familiarized with the treadmill over a one-week period via the completion of four 10-min running sessions from 0 to 9 m.min-1 (0, 3, 6 and 9 m.min-1). All mice succeeded in running for the required time at an intensity of 9 m.min-1. The velocity was not increased above this value, in order to avoid a training effect. The mice subsequently performed an incremental exercise test.
Incremental test load: Peak velocity, blood lactate and
Starting from a speed of 10 m.min-1, the exercise intensity was increased by 3 m.min-1 every 3 min, with an incline of 0%. Exercise continued until exhaustion, which was defined as an inability to maintain the running speed despite contact with the electric grid for more than 5 sec. All measurements were made by the same investigator. The last stage completed by the mouse was defined as the peak velocity (vPeak). Blood lactate levels were measured before the exercise and two minutes after the end of the exercise ([La]INC). After local antisepsis with alcohol, the distal 2mm of the animal's tail was cut off. To avoid contamination, the first drop of blood was discarded. Next, a 5 μl blood sample was collected on a small test strip and the blood lactate concentration was measured with a Lactate Pro assay (Arkray Inc., Kyoto, Japan).
Steady-state intensity exercise: The critical speed determination
The protocol consisted of four constant-speed runs (18–51 m/min) leading to exhaustion within one hour, as described in an earlier study
Exhaustive exercise at the critical speed and muscle collection
At least two days after the end of the determination of CS, vPeak and VO2max, all animals ran at their individual CS until exhaustion. We recorded the time to exhaustion and the blood lactate concentrations before and 2 min after the end of exercise ([La]SS). Mice were sacrificed by cervical dislocation 24h later. The tibialis anterior and soleus muscles were rapidly removed, immerged for 2 hours in RNAlater reagent (Ambion, Austin, TX) and then frozen in liquid nitrogen. The samples were then stored at -80°C prior to RNA extraction for microarray and RT-qPCR analysis.
Muscle gene expression analysis
Production of the murine long oligonucleotide microarray
Gene expression analysis was performed using a 25K mouse long oligonucleotide microarray [Gene Expression Omnibus accession number GPL8349:
RNA extraction
Total RNA was extracted from each muscle sample using a phenol-chloroform method (TRI
Microarray hybridization and signal quantification
Microarray hybridization
The tibialis anterior RNA extracts from each mouse were pooled into the corresponding EPO-d and control groups. Likewise, soleus muscle RNA extracts were pooled into an EPO-d group and a control group. Eight mouse 25K microarrays were used to analyze the samples using a dye-swap design.(2 groups x 2 muscles x 2). Briefly, the hybridization protocol
Ratio = fluorescence in EPO-d muscle / fluorescence in the corresponding control muscle
For statistical analysis, a log transformation ratio was used to normalize the distribution. A list of the significant genes were obtained by filtering the genes with a cut-off T-test (p-value < 0.05). Benjamini and Hochberg multiple testing correction was used to avoid a biased discovery rate
Real-time, quantitative PCR (RT-qPCR)
In order to validate the most significant results from the microarray analysis, quantitative RT-qPCRs were conducted in triplicate for the top ten up- and down-regulated gene transcripts in muscles from both EPO -d and control inbred mice. The primers were designed using Primer express software (Applied Biosystems, Life Technologies, Carlsbad, CA, USA) (Table
Data mining
A biological interpretation of the data was performed using two data-mining programs to identify the main biological functions and the main metabolic pathway disorders revealed by the expression profile in EPO-d muscles. Ingenuity® Pathway Analysis (
The analysis of the main metabolic pathways and their potential dysfunctions was performed using Predictsearch® software written in Java/Perl (Prediguard,
A Mann-Whitney U test was applied to compare variables in EPO-d mice with those in control mice variables. A Spearman test was used to test correlations between exercise parameters. A three-way analysis of variance was used to test the effects of EPO deficiency, muscle and gene on the RT-qPCR Ct values.
Exercise physiology
The two groups of mice did not differ significantly in terms of age and weight at baseline. The EPO-d group showed a two-fold decrease in Htc, relative to the control group (19.56 ± 2.74% and 40.75 ± 2.71%, respectively; p < 0.0001). The VO2max, vPeak, and CS performance indexes were lower in the EPO-d group than in the control group. However, the two groups did not differ in terms of the time to exhaustion at the CS (Tlim). The [La]INC measured at the end of the incremental exercise was higher in the EPO-d group, whereas the [La]SS values measured at the end of steady-state exercise at the CS were similar (Table
The VO2max and vPeak were correlated with the Htc in each group separately and when pooled (p < 0.05) (Figure
Figure 1
Correlations between hematocrit on one hand and peak velocity and VO2max on the other
Correlations between hematocrit on one hand and peak velocity and VO2max on the other.
Gene expression in skeletal muscles
Thirty-three percent of the microarray probes (especially those for mitochondrial genes) hybridized with a significantly high fluorescence value. All the data from the present study have been deposited in the Gene Expression Omnibus (accession number pending). After filtering the normalized expression ratios with a cut-off at p < 0.05 (i.e. a significant difference from 1), a total of 1583 genes exhibited significant changes of expression levels between the EPO-d and the control mice ( Additional file
Additional file 1
Table S1. Title: List of all significantly modulated genes. Description of data: List of all the significantly modulated genes (p < 0.05) expressed in the tibialis and soleus muscles of EPO-deficient and control mice. The p-value (p < 0.05) indicates that the expression ratio differed significantly from 1.
Click here for file
The changes for 23 strongly up- and down-regulated genes (according to the microarray analysis) were validated by RT-qPCR analysis (Table
Gene functions and pathways
We used Ingenuity Pathway Analysis® to classify our list of modulated genes by cellular function and by canonical and signaling pathway. Three groups of functions were detected (Table
The tissue, organ and cellular context and the associated biological activities were further investigated with a Predictsearch® analysis. Using the PubMed database, it was found that 31 of the significantly modulated genes were strongly associated with the following biological activities: apoptosis, proteolysis, glycolysis, cellular trafficking and cytoskeleton. In addition, the most frequently cited disease pathways in relation to the gene set were muscle atrophy, hypoxia and oxidative stress. The main pathway disruptions revealed by Predictsearch® data mining are described in Figures
Figure 2
Main pathway disorders leading to muscle proteolysis, atrophy, hypoxia and anti-oxidant response
Main pathway disorders leading to muscle proteolysis, atrophy, hypoxia and anti-oxidant response. Legends of the figures
Figure 3
Impairment in ATP production. Impaired ATP production, with down-regulation of genes involved in glycolysis, mitochondrial oxidative phosphorylation and the phosphocreatine kinase pathway
Impairment in ATP production. Impaired ATP production, with down-regulation of genes involved in glycolysis, mitochondrial oxidative phosphorylation and the phosphocreatine kinase pathway. Other than some moderately up- or down-regulated subunits of NADH dehydrogenase, most of the genes were down-regulated. Legends of this figure are provided in Figure
Figure 4
The gene regulation of cytoskeleton components
The gene regulation of cytoskeleton components. None of the genes were significantly up-regulated (x > 1.4) but seven were moderately up-regulated ( 1 > x > 1.4). All other genes in this category were moderately or severely down-regulated. Legends of this figure are provided in Figure
Figure 5
Down-regulation of many genes involved in intracellular trafficking
Down-regulation of many genes involved in intracellular trafficking. Legends of this figure are provided in Figure
The forkhead box O1 (Foxo1) gene was significantly over-expressed and may activate muscle proteolysis in conjunction with three other up-regulated genes involved in the muscle proteasome (Ube2g1) and E3 Ubiquitin ligase (Chfr and Cbl) (Figure
Seven genes coding for cytoskeleton components were moderately up-regulated (1 < x < 1.4) and all the other genes were moderately or significantly down-regulated (Figure
Most of the studies on muscle exercise or doping are based on the use of acute or chronic EPO injection to stimulate endurance capacity. In the present study, the EPO-d model was used to study the effects of EPO loss-of-function on the muscles of exercising mice. To date, the study of adult EPO-d animals has been limited by the fact that EPO gene knock-out (KO) is embryonic lethal
In the present study, reductions of between 25% and 30% in vPeak, VO2max, and CS attested to the subnormal exercise performance in EPO-d mice. However, the time to exhaustion was not different between groups. This is not consistent with the 50% decrease (vs. controls) in the time to exhaustion in a swimming test observed in a murine CKF model with a low Htc (28% lower than in controls). However, the intensity of the swimming exercise was not quantified and the absolute intensity was probably similar in the two groups. In the present study, performance was first assessed in terms of vPeak and VO2max. Next, the intensity chosen for the exhaustive exercise (at CS) was individually related to performance (at around 80% of vPeak); thus, all mice were exercising at the same relative intensity. This explained the fact that the time to exhaustion was similar in the two groups and confirmed the relevance of CS in the running mouse model
This set of physiological results emphasized the poor endurance capacity in EPO-d mice, which may be related to their impaired aerobic capacity relative to control mice. They exhibited a lower VO2max and higher blood [La]INC which are physiological signs of hypoxia. This was confirmed at the genomic level by strong up-regulation of Hif1a, which acts as the master regulator for the expression of genes involved in the hypoxia response in most mammalian cells
The present transcriptome data mining analysis showed that the EPO deficiency induced expression changes in genes related to muscle hypoxia and proteolysis. In addition, 12 significantly modulated genes were involved in cell death and apoptosis (Table
In the present study, some results were consistent with a potential role of EPO in the anti-apoptotic pathway in exercising muscle. We found that EPO-R, nitric oxide synthase 2 inducible (Nos2) and Akt1 were down-regulated in EPO-d mice. Akt is also associated with muscle protein synthesis and hypertrophy
Figure 6
Overview of the direct and indirect effects of EPO loss-of-function on muscle
Overview of the direct and indirect effects of EPO loss-of-function on muscle. On the basis of the present study's results, our model seeks to explain the impact of a lack of functional EPO on muscle tissue in the EPO-d mouse.
From a physiological point of view, our study validated the EPO-d mouse model by demonstrating worse exercise performance than in control mice with a normal Htc. This poor exercise performance could be explained by the lower Htc, chronic hypoxia, muscle oxidative stress and the severe muscular proteolysis revealed by the transcriptome analysis. Our results suggest that physiological levels of EPO cytokine exert both direct and indirect protective effects on muscle during exercise. However, the signaling pathway involved in these protective effects remains to be described in detail.
[La]INCBlood lactate concentration at the end of the incremental protocol[La]SSBlood lactate concentration at the end of the steady-state protocolaaRNAAmino-allyl RNAAkt1Protein kinase BB4galtbeta-1,4-galactosyltransferaseBcl2B-cell lymphoma 2CbtCabutChac1Cation transport regulator homolog 1CHFChronic heart failureChfrCheckpoint with fork-head associated and ring fingerCKFChronic kidney failureCkmMuscle creatine kinaseCln3Juvenile neuronal ceroid lipofuscinosisCSCritical speedCtCycle thresholdCTSDCathepsin DCYGBCytoglobinDTTDithiothreitolE1f4g2Eno3, enolase 3eNOSEndothelial nitric oxide synthaseEPOErythropoietinEPO-dErythropoietin-deficientEPO-RErythropoietin receptorFoxo1Forkhead box protein O1Hif1aHypoxia-inducible factor 1 alphaHsp70Heat shock protein 70HtcHematocritMdh2Malate dehydrogenase 2MIFMacrophage migration inhibitory factorNos2Nitric oxide synthase 2Pi3kPhosphatidylinositol 3-kinasesrHuEpoRecombinant human erythropoietinROSReactive oxygen speciesRtn2Reticulon 2Serpinb2/Pai2Syngr2, synaptogyrin 2TlimTime limitTomm40Translocase of outer mitochondrial membrane 40 homologUbe2g1Ubiquitin-conjugating enzyme E2 G1VEGFVascular endothelial growth factorvPeakPeak velocity
Competing interests
The authors declare that they have no competing interests.
Author's contributions
LH, EB, VB designed the study and drafted the manuscript. LH, EH carried out the mouse tests and physiological analysis. EB, BB carried out the transcriptomic analysis. EH, EB carried out the qPCR validation. FJ, PB carried out the transcriptomic interpretation. All authors read and approved the final manuscript.
This study was funded by a Genopole® ATIGE grant (Evry, France) and the French National Institute of Health and Medical Research (INSERM).
Animals were kindly provided by Nokad® (Evry France). The authors thanks Dr Amine Abina for his contribution to conception and design of the study, and Macha Musulmani for her help in the collection of biological tissue.
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Epo is relevant neither for microvascular formation nor for the new formation and maintenance of mice skeletal muscle fibres in both normoxia and hypoxia
Impact of alterations in total hemoglobin mass on VO 2max
Chronic inborn erythrocytosis leads to cardiac dysfunction and premature death in mice overexpressing erythropoietin
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Erythropoietin protects cardiomyocytes from apoptosis via up-regulation of endothelial nitric oxide synthase
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PI3 kinase regulation of skeletal muscle hypertrophy and atrophy
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PI3K/Akt is required for heat shock proteins to protect hypoxia-inducible factor 1alpha from pVHL-independent degradation
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Oxidation enhances myofibrillar protein degradation via calpain and caspase-3
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Pre-publication history
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