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SOPP 8508: Procedures for Handling Adverse Reaction Reports Related to "361" Human Cells, Tissues, and Cellular and Tissue-Based Products (HCT/Ps)
Version #2
Effective Date: March 26, 2008
- Purpose
- This SOPP describes the procedures that the Center for Biologics Evaluation and Research (CBER) should routinely follow when receiving reports of adverse reactions associated with HCT/Ps. This SOPP also will address the necessary framework for efficient communication between points of contact in the Office of Biostatistics and Epidemiology (OBE), Office of Cellular, Tissue, and Gene Therapies (OCTGT), Office of Compliance and Biologics Quality (OCBQ), Office of the Director (OD) and the Office of Communication, Training and Manufacturers Assistance (OCTMA), and between other appropriate Food and Drug Administration (FDA) staff, and non-FDA participants.
- Definitions
An HCT/P is an article containing or consisting of human cells or tissues that is intended for implantation, transplantation, infusion, or transfer into a human recipient [21 CFR 1271. 3(d)]. An HCT/P is regulated solely under section 361 of the Public Health Service (PHS) Act and applicable regulations in 21 CFR Part 1271 if it meets all of the criteria described in 21 CFR 1271.10(a). An HCT/P that falls into this category is sometimes referred to as a "361" HCT/P.
If the HCT/P does not meet the criteria in 1271.10(a), then the HCT/P is regulated as a drug, medical device, or biological product under the Federal Food Drug and Cosmetic Act and/or section 351 of the PHS Act and other applicable regulations in Title 21 CFR in addition to applicable regulations in 21 CFR Part 1271.
MedWatch is the FDA safety program for reporting adverse reactions/events and problems associated with medical products, including HCT/Ps (http://www.fda.gov/medwatch). Manufacturers use form FDA 3500A for mandatory reports. Consumers, health professionals, and other respondents use Form FDA 3500 for voluntary reports.
Adverse Reactions for "361" HCT/Ps per 21 CFR 1271.350(a)
An adverse reaction means a noxious and unintended response to any HCT/P for which there is a reasonable possibility that the HCT/P caused the response [21 CFR 1271.3(y)].
Any adverse reaction involving a communicable disease related to an HCT/P made available for distribution must be investigated [21 CFR 1271.350(a)(1)] by the manufacturer that made the HCT/P available for distribution.
An adverse reaction involving a communicable disease related to an HCT/P made available for distribution must be reported to FDA if the adverse reaction:
- Is fatal;
- Is life-threatening;
- Results in permanent impairment of a body function or permanent damage to body structure; or
- Necessitates medical or surgical intervention, including hospitalization.
HCT/Ps regulated as drugs, medical devices, or biological products
The TST only reviews adverse reaction reports for "361" HCT/Ps. The websites below are being provided for your information only. The appropriate regulations for reporting pre- and post- marketing medical device reports and adverse experience reports for HCT/Ps that are regulated as drugs, medical devices, or biological products are:
Medical devices:
Approved/cleared device
http://www.access.gpo.gov/nara/cfr/waisidx_07/21cfr803_07.html http://www.fda.gov/cdrh/mdr/mdr-general.html
Biological products and drugs:
21 CFR 312.32 and 21 CFR 312.64
21 CFR 7.3(g) defines a recall as a firm's removal or correction of a marketed product that FDA considers to be in violation of the laws it administers and against which FDA would initiate legal action. Recalls may be conducted on a firm's own initiative, by FDA request, or by FDA order under statutory authority.
Market Withdrawal
21 CFR 7.3(j) defines a market withdrawal as a firm's removal or correction of a distributed product which involves a minor violation that would not be subject to legal action by FDA or which involves no violation.
Tissue Safety Team
The Tissue Safety Team (TST) consists of CBER representatives from OBE, OCTGT, OCTMA, OCBQ and OD. The primary purpose of the TST is to provide a coordinated process for the review, investigation, and communication of reports of HCT/P adverse reactions. The TST develops procedures and policies to facilitate rapid and comprehensive responses by FDA and other agencies, as appropriate, to reported adverse reactions. Other activities include outreach and education, and development of recommendations regarding tissue safety.
- Background
CBER has received reports of a number of adverse reactions associated with the use of "361" HCT/Ps. CBER asserts that it is important to investigate, track, and monitor these events to minimize public health risks. The Current Good Tissue Practice regulations [21 CFR 1271.350(a)] require manufacturers of HCT/Ps to report certain adverse reactions involving communicable disease to FDA.
To ensure that the responsibilities for addressing reported adverse reactions associated with HCT/Ps are clearly established, CBER formed a Tissue Safety Team (TST) in 2004 to monitor these adverse reaction reports and to coordinate any related activities. This SOPP delineates responsibilities and identifies points of contact within CBER as well as other FDA components and HHS agencies.
In addition to reports from manufacturers, CBER may receive voluntary reports of adverse reactions from other sources including other FDA Centers or HHS agencies, health care professionals, hospital personnel, and consumers. Some reports may not have a MedWatch form associated with them (for example, a consumer injury complaint reported to a district office or to OCTMA). CBER will track and monitor adverse reaction reports received (regardless of the format or reporting mechanism used) and initiate and coordinate investigations as appropriate. When HCT/P adverse reactions are reported to FDA in a format other than MedWatch, reporters will be contacted and encouraged to submit a MedWatch report.
Examples of "361" HCT/Ps that meet the criteria in 21 CFR 1271.10(a), and for which reporting is required, are:
- Amniotic membrane when used alone or without added cells
- Bone
- Cartilage
- Cornea
- Fascia
- Ligament
- Pericardium
- Peripheral or umbilical cord blood stem cells (for autologous use or use in a first or second degree blood relative)
- Sclera
- Skin
- Tendon
- Vascular graft, except when used in association with organ transplantation and labeled as such
- Heart valves
- Dura mater
The following HCT/Ps meet the criteria in 21 CFR 1271.10, but adverse reaction reporting currently is not required. Voluntary reports may be submitted using Form 3500:
- Semen
- Oocytes
- Embryos
Adverse reaction reporting also is not required for "361" HCT/Ps procured before 21 CFR 1271.350 became effective (i.e., before May 25, 2005). Voluntary reports may be submitted using Form 3500.
- Policy
- It is CBER's policy that all HCT/P adverse reaction reports will be investigated, tracked, and monitored by the TST Working Group (WG), which is composed of a subset of representatives of the full TST. On a monthly basis and when deemed necessary on a case-by-case basis, the TST WG will brief the TST regarding ongoing investigations. On a quarterly basis and when deemed necessary on a case-by-case basis, the TST will brief the OD/CBER regarding ongoing investigations. The TST will develop any internal and external communications necessary regarding adverse reactions.
- Responsibilities and Procedures
- MedWatch Reports
OBE Responsibilities
OBE is the official contact for MedWatch reports involving HCT/Ps. OBE is responsible for processing and epidemiologic review of the reports, as well as for making reports available to the appropriate contacts within CBER for review and follow-up.
Upon receipt of a report of an adverse reaction associated with an HCT/P, the OBE staff person receiving the report will forward it to the OBE point of contact for the TST WG (see Appendix 1). OBE will open a record in the Adverse Event and Product Problem (AEPP) database and enter pertinent details for review by other TST WG members. However, reports of adverse events for CDRH-regulated devices, reports submitted as part of an Investigational New Drug (IND) protocol, and biological product deviation reports are not entered into AEPP, and are forwarded as appropriate. All MedWatch reports for HCT/Ps and other CBER-regulated products are stored in the Adverse Events Reporting System (AERS) database; OBE maintains a list of HCT/P active ingredients for designation of products within AERS.
OBE will notify the OCBQ POCs of reports that may need manufacturer follow-up. OBE will immediately notify the TST WG on any urgent matters (such as infections in multiple recipients of tissue from the same donor, infections involving virulent pathogens, recipient fatalities, product contamination). OBE will forward adverse reaction reports involving cell and cellular-based products to the OCTGT POC for cell reports for clinical follow-up.
OBE will assess the adverse reaction report to determine the need to conduct a clinical follow-up investigation (e.g., if details are needed about the time to onset of symptoms or the recipient outcome). If additional information is needed, OBE will contact the reporter and ask appropriate clinical questions. OBE will summarize the information received from the reporter and enter the summary into AEPP. OBE will immediately notify the TST WG on any urgent matters that arise from follow-up investigation.
OBE's POC will set up bi-weekly meetings of the TST WG (Appendix 1) as needed to discuss open reports and other issues related to the operation of the TST. For TST Quarterly meetings, OBE will present a descriptive summary of the number and types of reports received in the previous quarter, and will present selected cases.
OCBQ Responsibilities
OCBQ will contact the HCT/P manufacturer, when necessary. The decision to contact the manufacturer will be based on historic precedent or, when faced with a new scenario, will be consultative among members of the TST WG. OCBQ will request additional relevant information regarding the tissue involved (e.g. information regarding donor eligibility or tissue processing). Information received from the manufacturer will be reviewed and summarized by OCBQ and entered into AEPP. OCBQ will notify the OCTGT and OBE POCs if OCBQ determines that the information obtained from the manufacturer needs their review prior to the next TST WG meeting (for example, to review and interpret donor clinical information). OCBQ will immediately notify the TST WG on any urgent matters that arise from follow-up investigation.
If it is determined that a directed inspection assignment is warranted, OCBQ will write the assignment and shepherd it through the approval process.
OCTGT Responsibilities
OCTGT is responsible for the medical/scientific assessment of each case. The OCTGT POC will obtain scientific information about the microorganism involved, in order to determine its significance. OCTGT will share this information with other TST WG POCs. OCTGT will review donor information received from the tissue manufacturer, such as donor eligibility records and autopsy reports, if necessary or upon request by OCBQ.
The OCTGT POC for cells will perform clinical and manufacturer follow-up on cell reports as needed and present these cases at TST WG meetings. If the POC for cells is not available to perform follow-up in a timely manner, the OCTGT POC for all other reports will perform follow-up.
The OCTGT POC will arrange monthly meetings with the entire TST (Appendix 2), as needed, to discuss selected cases and policy issues. The OCTGT POC also will arrange quarterly meetings of the TST and the Immediate Office of the Director (OD) (Appendix 4), as needed, to discuss significant cases and policy issues, and brief OD on other TST activities.
OCTMA Responsibilities
If OCTMA receives information about an adverse reaction from a consumer, healthcare professional, consignee, or manufacturer, OCTMA will forward this information to the OBE POC (Appendix 1).
TST Joint Responsibilities
The TST WG (Appendix 1) will meet bi-weekly, as needed. It will evaluate all HCT/P reports submitted to FDA and information collected during follow up investigation, if any. The TST Chair will determine when the investigation by the TST is complete and seek concurrence with others on the TST WG. The TST Chair or designee will close the case in AEPP, indicating that the TST investigation is complete and, based on the information, no further action is warranted. Cases may be re-opened if new information that warrants further action becomes available.
If the TST Chair is notified about an urgent matter (e.g. through OBE or OCBQ notification of the TST WG), the TST Chair will determine whether the TST (Appendix 2) and the CBER OD (Appendix 4) should be notified of the event, and will carry out such notification.
If the TST WG determines that the investigation of, or response to a report requires involvement of contacts outside of CBER (Appendix 3), the TST Chair will assign to TST WG members responsibility for initiating these contacts.
OD Responsibilities
If the Emergency Operations Manager (EOM) from the CBER OD receives information about an Emergency/Serious Adverse Reaction or safety issue from the Office of Crisis Management/Office of Emergency Operations, the EOM will disseminate this information to the TST WG. The EOM will also communicate general information about the TST activities to CBER OD Senior Management as needed.
Interaction with CDC
CDC may provide infectious disease expertise and/or laboratory testing (e.g., cultures of donor and/or recipient tissues and/or materials; identifying and/or genetic typing of isolates, etc.). When necessary, CDC also may notify consignees of potential safety risks, in coordination with state and local health departments. Information exchanges between FDA and CDC will be consistent with the principles and procedures outlined in the Memorandum of Understanding between FDA and CDC (MOU Number 225-06-8401).
Communication with Foreign Government Regulatory Authorities
In the event of consignee notification involving HCT/Ps distributed to foreign countries, the OCBQ Director will notify the International Affairs Advisor in the Office of the Director (Appendix 5). The International Affairs Advisor will perform/coordinate any necessary notification of foreign regulatory authorities. If communications are needed with foreign regulatory authorities for other reasons, the International Affairs Advisor also will coordinate those on behalf of the TST.
- Recalls and Market Withdrawal
OCBQ's Division of Case Management (DCM) is the official contact in CBER for recalls. If OCBQ/DCM is informed of a firm's decision to notify consignees of a distributed product involved in or related to a potential or actual communicable disease transmission, OCBQ/DCM will immediately inform the TST Chair. The TST Chair will determine whether the TST (Appendix 2) and the CBER OD (Appendix 4) should be notified of the event, and will carry out such notification.
- Other Reports
The CBER Office that is contacted by an outside agency (e.g. CDC or HRSA), the public, or other FDA component about an adverse reaction involving an HCT/P should follow the procedure above. The outside reporter will be encouraged to file a MedWatch report.
- Discussion with CBER Upper Management
The TST Chair will contact CBER OD (Appendix 4) about any important HCT/P safety concerns. At TST quarterly meetings, the OD will be briefed on all significant cases and policy issues.
- Effective Date
March 27, 2008
- History
Written By Approved By Approval Date Version Number Comments Laura St. MartinRobert YetterMarch 26, 20082Administrative procedures updated Martha Wells
Anita RichardsonRobert Yetter
February 28, 2005 1Original version
Appendix 1: Tissue Safety Team Working Group & Points of Contact (POCs)(PDF - 23KB) Appendix 2: Tissue Safety Team(PDF - 25KB) Appendix 3: Points of contact for other agencies or personnel within FDA(PDF - 28KB) Appendix 4: CBER Office of the Director(PDF - 19KB) Appendix 5: International Affairs Advisor(PDF - 14KB)


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By Nate Ryan, USA TODAY
On a sun-kissed Saturday in the rolling hills of Sonoma Valley's wine country, Kyle Busch was buried on the Sprint Cup speed charts.
The leading winner in NASCAR's premier series was ranked 39th after the first of two tuneup sessions at Infineon Raceway, struggling for speed in all 12 turns of the twisting 1.99-mile circuit where he had qualified 30th a day earlier.
Before the final practice, crew chief Steve Addington huddled with Andy Graves, who oversees all the at-track support for Toyota Racing Development (TRD) as its Sprint Cup program manager.
Addington had a litany of setup suggestions from Joe Gibbs Racing engineers for teammates Denny Hamlin and Tony Stewart. Graves brought a boatload of chassis and engine data gleaned from Toyota's other teams. They cobbled together a fresh combination of suspension changes and popped it into Busch's No. 18 Toyota Camry.
In the next practice, he shot to 11th. The next day, he roared to the first road-course win of his career.
"That was truly the point I just thought, 'Man, this kid is really special,' " Toyota Racing Development President Lee White says. "Let's be real: If it weren't for Kyle Busch, we'd have two wins this year."
"The Kid," though, thinks a lot of his new ride, too.
"It's Joe Gibbs Racing which has been the biggest step to Toyota's performance increase this year," Busch says, "but the Toyota guys have been able to help us in a lot of areas, too."
A year ago heading into the season-ending 10-race title run, Toyota didn't have a car in the top 35 — meaning none of its cars was guaranteed a spot in qualifying each week.
A year later, led by Busch, the 23-year-old wunderkind who enters the Chase for the Sprint Cup as the top seed with a series-high eight victories, Toyota has a triple threat for stock car racing's ultimate prize.
For the first time in the five-season history of the Chase, JGR qualified all three of its racers for the 12-driver field 10-race run that determines the Cup champion.
After a 15-year run with General Motors that included two championships, 41 pole positions and 58 victories, team owner Joe Gibbs gambled on becoming the linchpin operation for a manufacturer that never finished higher than third while failing to qualify in 91 of 252 attempts in its rookie Cup season.
It's clear switching to Toyota wasn't the Hail Mary many thought the former Washington Redskins coach was calling in leaving the comfort of Chevrolet, which won 25 of the 36 points-paying races last season in capturing its third consecutive manufacturer championship.
"Anytime you switch manufacturers, you're worried about them getting off to fast starts," Gibbs says. "I couldn't be more impressed with Toyota and the partnership. Our guys and their guys really meshed and worked extremely hard. Could I have guessed we could have gotten off to this kind of start? No."
But Toyota's success hasn't been limited to its new powerhouse addition. The start-up teams that became synonymous with its first-year struggles are making remarkable strides.
"Joe's process hasn't changed much; he had a championship-caliber team with Chevy and put new dresses on his girls, and that continued," team owner Michael Waltrip says. "To mark the progress, you have to look at Red Bull (Racing) and us establishing ourselves. I could have won two races this year (at Talladega Superspeedway and New Hampshire Motor Speedway)! We couldn't have said that last year. That's big progress."
Michael Waltrip Racing, which made 69 of 108 starts with three cars in 2007 while battling the year-long taint of an illegal fuel scandal before the Daytona 500, has qualified its trio for every race and ranked in the top 35 for much of 2008.
Red Bull Racing went all the way to the cutoff race at Richmond International Raceway with a shot at qualifying for the Chase with Brian Vickers' No. 83 Toyota.
While sponsorship woes have hampered Bill Davis Racing, White says the second-year success of Toyota's "freshman class" proves the Japanese manufacturer is making inroads into Cup as quickly as its top-selling Camry did in the U.S. marketplace. "We've come a long, long ways toward understanding how to do this," he says. "The association with Joe Gibbs was instrumental in teaching us how to do it better. Just that has improved (TRD) dramatically and, by osmosis alone, has improved our ability to help the other guys."
Red Bull Racing general manager Jay Frye says TRD is "as proud of its freshman class as an elite team like Gibbs" and has provided multitiered support, from engines to technical data to historical statistical analysis of races. "It's a partnership; they work hard to help us improve,"he says. "They're very open to listen to any ideas we have. If we ask them to look into something, they're on it immediately. It's the little things they do to help enhance what we're doing. They're going to be a force to be reckoned with for a long time in this sport."
Diversified company
Though relatively new to NASCAR, TRD has been around for nearly 30 years.
The main headquarters for the 230-employee company is an 80,000-square-foot state-of-the-art facility in Costa Mesa, Calif.,
Besides stock cars, TRD also supplies motors for Toyota-backed teams in the National Hot Rod Association, Championship Off Road Racing and the U.S. Auto Club Sprint and Midget series and helps prepare Lexus motors for the Grand-Am Rolex Sports Car Series.
TRD-powered cars have captured four Rolex 24 at Daytona wins, numerous desert racing victories in the Baja 500 and 1000, five Pikes Peak Hill Climb championships, several triumphs in the 12 Hours of Sebring and manufacturer titles in off-road and sports car.
Before pulling out of Indy-car racing in 2006, TRD-powered cars won the 2003 Indianapolis 500 (with Gil de Ferran), the 2003 Indy Racing League IndyCar Series title with Scott Dixon and several Champ Car World Series and IndyCar races.
Its Southern California base is loaded with multimillion-dollar equipment such as dynamometers used to test engine strength, and its engineering staff is more than 50 strong with the experience of working with its high-tech Formula One team in Japan.
But the white lab coat approach wasn't an immediate fit with the blue-collar environs of NASCAR, whose prehistoric engine rules and designs date to the 1950s era of carburetors and pushrods.
Though many Cup teams are using advanced computer simulations and F1-style metallurgy to construct their motors, simply throwing technology at a 60-year-old sport with firmly planted roots doesn't work.
White says the key to success in NASCAR is marrying tribal knowledge with technical sophistication, and Toyota lacked an institutional understanding of stock car racing.
"We've got many guys with Ph.D.'s and advanced master's degrees," White says. "They're not guys who grew up at your local short track. It takes a little while to evolve them into two-valve, pushrod NASCAR technology.
"Before we (were doing) a lot of advanced engineering projects … but because we hadn't taught ourselves to understand the grass-roots level of NASCAR, we didn't know how to apply that.
"Probably the major thing we've learned from the Joe Gibbs organization is how to mesh old-fashioned, crew-chief-driven knowledge with some of the most advanced engineering techniques in the world. Sometimes you have to educate very bright people to embrace the fundamentals."
JGR helped fill in much of the basics with its wealth of technical expertise and talent.
Engine builder Mark Cronquist long has been regarded as one of NASCAR's brightest in generating horsepower, and he took two Toyota engineers under his wing full time to learn the nuances of building a gasoline-powered engine after 15 years of developing methanol-burning power plants in Indy cars.
"It's a fundamental difference in philosophy," White says. "To run a basic pushrod V8 with a Holly carburetor is something that we had the most to learn. It took about six months for the lights to come on and people to go down that path.
"Driving everything with advanced engineering doesn't necessarily get you where you need to be. You don't race those $3 million dynos."
Toyota's major deficiencies last year were in the middle of what engine builders call "the power curve." When its motors were turning maximum RPMs at the top of the curve, the horsepower was on par with top-tier teams.
But at short tracks and flat superspeedways with sharp corners such as Indianapolis Motor Speedway and Pocono Raceway, where drivers are off the accelerators for long stretches in the turns and RPMs fall from close to 10,000 to about 5,000, the Camrys couldn't keep up.
Vickers says Toyota solved that problem and several others quickly during the offseason.
"Last year we were struggling on most fronts: power, reliability and a lot of different areas," he says.
"This year, they've really stepped it up. The superspeedway power has come a long ways. The beginning of this year, we were as good as the best, right there with Gibbs and Hendrick (Motorsports), probably the two best engine builders in the sport."
JGR, which had played a major role in developing Chevy's next-generation R07 engine a year earlier, disseminated newer designs to TRD, which had lacked the ability to lean on its lesser freshman class for such information.
After supplying engines for championship-caliber teams Penske Racing and Chip Ganassi Racing in IndyCar, Toyota was less prepared for supporting teams that were focused on just making the field.
"Our engineering and vehicle dynamics is more geared toward getting a car from 10th to fifth," says David Wilson, senior vice president of TRD. "Our freshman class was working on getting from 35th to 20th. Our skill sets were more focused on the higher end."
Group dynamics
So was JGR, which had no intention of leveling off in results after winning three championships with Stewart (2002, 2005) and Bobby Labonte (2000).
Mindful of bringing other Toyota teams to its level in order to accelerate the manufacturer's research and development overall, JGR began loaning out shocks specialist Ronnie Crooks from the outset of preseason testing at Daytona International Speedway.
Crooks since has remained a fixture in flitting between the garage stalls of other Camrys, bouncing between the crews of the Waltrip, Red Bull and Davis teams to offer advice.
"There's a lot of stuff we brought that helped," JGR President J.D. Gibbs says. "Hopefully we'll help elevate the other guys and they'll help elevate us. It's got to be a two-way street, and we're starting to see that. Down the road it's more important. It'll make our team stronger, the other TRD teams stronger and, as a group, we'll pull in the same direction with more force."
White says working as a group is TRD's overarching philosophy.
When Toyota entered the Craftsman Truck Series in 2004, it embraced a free flow of information between teams that helped secure consecutive manufacturer titles in 2006 and 2007.
"After every practice, our truck crew chiefs get together and open the book to show tire pressures and chassis settings," White says. "That's probably very optimistic to think that will happen in the Cup series because there's too much at stake.
"But there are a lot of projects that can be done as a group that can better everyone while preventing our teams from spending money on doing the same projects."
TRD provides plenty of individual support, too.
When Vickers suffered engine failures in back-to-back races, Toyota engineers remedied the problem immediately.
After a faulty fuel pump cost Hamlin a win at Bristol Motor Speedway for the second consecutive season, the manufacturer reassigned a team of engineers to find a solution.
"They were the first to step up and say, 'No matter what it takes, we'll pay for it and get it taken care of,' " Hamlin says. "That was a big help, having a manufacturer that's willing to go above and beyond.
"Andy Graves and his guys are always checking with us before and after practice, asking, 'Hey, is there anything we can get from any other teams that can help you?' "
Helping hands
The help goes well beyond engines, too. TRD engineers have been embedded in the Waltrip shop to work on aerodynamics, and Gibbs also has taken advantage of supplementing its engineering staff with TRD help.
When JGR switched to Toyota, team vice president of competition Jimmy Makar said the move was akin to "hiring an extra 100 people" — essential, given that JGR's 400-employee company still has about 100 fewer employees than both four-car Hendrick Motorsports and five-car Roush Fenway Racing.
"In the past, there's been certain things we can't do because we didn't have the financial wherewithal," J.D. Gibbs says. "We've seen Toyota really be able to jump on and help us with car stuff, aero stuff, definitely not just engines.
"I'd say they have pretty big resources. Compared to GM, they work on projects that everyone shares. Before (at Chevy), it was a Joe Gibbs or Hendrick project. Chevy had four really strong teams and would dish those guys information and resources, but not a whole lot was pooled together. Toyota has a good chunk that everyone shares."
Says Vickers, who drove for Hendrick for four seasons before joining Red Bull, "What differentiates Toyota from other manufacturers is the organization. Chevy, Ford and Dodge do quite a bit with engine stuff, but it's not quite as structured as Toyota."
Toyota has strong odds to win its first championship in only its second Cup season, and its competitors might be worried that the Japanese giant that has sold more cars worldwide than any other in 2008 can grow even stronger in NASCAR.
The Gibbs and Red Bull teams are working on strengthening their alliance, which would give JGR access to Red Bull's Formula One team in Europe and much advanced technology.
"We're looking to do more things with them because we have access to things they don't have," Frye says of Red Bull.
JGR also is trying to work more closely on engines with TRD, which builds engines for Waltrip and Red Bull in California. Gibbs has an in-house motor program in its Huntersville, N.C., shop.
"At some point, we would hope that TRD and Gibbs will build the same engine, so all of our teams can race an engine assembled from the same components," White says.
TRD is taking a big step toward solidifying its NASCAR operations this fall by opening a 40,000-square-foot chassis and engineering headquarters in Salisbury, N.C.
That will make Toyota the only manufacturer in NASCAR with such a wide footprint near the sport's hub of Charlotte, and White doesn't envision another anytime soon.
"TRD didn't just happen four years ago when we went to NASCAR," he says. "It's a 29-year investment in capital and facilities and people.
"The most valuable asset is the intellectual property hidden inside our 230 people."
Well, that, and the raw ability inside a 23-year-old budding superstar named Kyle Busch.
"I've done this a long time and worked with some really great drivers," White says.
"I don't have words to describe how special Kyle seems."
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IBM Europe, Middle East and Asia vice-president and general counsel Carl Belding has quit the company after more than 20 years to become the chief legal officer at Nokia.
Belding was also the vice-president and assistant general counsel for the global sales and distribution arm of IBM. He was the first non-American to be appointed general counsel at the technology giant.
Belding carried enough clout within IBM to command use of the company's private jet and is ranked by peers as among the top five general counsel in Europe.
The Nokia post is a new position, created to provide a focal point for Nokia's 152 lawyers operating in 130 countries. Belding will report to new chief executive officer (CEO) Olli-Pekka Kallasvuo.
Kallasvuo's appointment as CEO led to the resignation of former general counsel Ursula Ranin to avoid a conflict of interest, as it is understood the pair have a personal relationship.
Belding will start at Nokia on 1 January 2006. IBM has a history of promoting from within and industry insiders are expecting a similar succession this time around.
Nokia is known to farm out work to a wide range of firms and does not have a centralised legal panel. Lawyers in regional jurisdictions currently operate with autonomy.
Belding, a Swede, will be based at the Finnish telecom giant's Helsinki headquarters, and it is understood that the Nordic connection played a significant role in the move. He had been based in Paris with IBM but was in the process of relocating to Geneva.
A Nokia spokesperson said: "Obviously we're very happy to have him; after all, he is from a neighbouring country."
Belding declined the opportunity to comment.


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From all-creatures.org
The Healing Power of Prayer
Faith healers are not as numerous today as they were in the old west, when people were often led more by superstition than Truth. But there was one who made a pretty good living laying hands on the sick. Reverend Jeffrey Prayer knew how to shape the beliefs of others to suit his personal objectives.
If the sick did not recover, he would say they did not have enough faith or harbored some secret sin that needed to be repented of before they could be healed. It was a slick operation. He was never to be blamed or held accountable for the failure to heal, while reaping the benefits, both promotionally and financially, for those who did get well.
He was very successful for several years, holding healing services and taking up offerings, until one day he got sick and eventually died. I wonder what his secret sin was?
Copyright © 2008 Mark Edgemon
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text:
On Sat, 05 Mar 2005 01:26:45 -0700, Dave Warren
<maillist at devilsplayground dot net> wrote:
> Question about the "block private networks" setting. What exactly does
> this do in terms of the firewall rules it creates?
> The reason I ask, I've noticed that even with this option enabled I can
> access a web server at http://192.168.100.1/ -- The webserver is part of
> the SURFboard modem I'm using, so it's existence isn't unwanted, but it
> made me curious why this works.
> I'm guessing that the rule that allows stateful connections is above the
> rule which blocks traffic from private networks, and that there is
> nothing similar blocking outbound traffic.
Any rules on the WAN side don't affect outbound connections because
the return traffic will be permitted by the state table. Block
private networks drops inbound traffic to m0n0wall's WAN side
initiated from RFC 1918 nets.


text:
Each month, Rated People connects over 50,000 homeowners with quality tradesmen - simply enter your job details in the form above to get started.
We'll match your job to the relevant tradesmen in your area - those interested will pay to see your contact details and call you to quote.
As each tradesman expresses interest in quoting on your job, we'll send you their profile and ratings to help you choose the right one for you.
After the work is complete, return to the site and rate your tradesman based on their quality of work, reliability and value for money.
Added 21/03/2017
I am getting water running down the bathroom wall whenever there is a heavy rainfall. I have...
Added 14/11/2016
Take down plasterboard wall between kitchen and dining room. May need support joist.
Added 24/09/2016
Size of extension: 1 room Repairs Architectual plans have been drawn up for this job Planning...
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Remove and repair pebble dash wall coating - approximately 10 different places on exterior...
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Very pleased with the job. Substantial internal wall removed, steal beam installed, boarded and plastered all in one day. Would recommend.
Managing your job is easier with the Rated People Homes App, download it today.


text:
'"A lot of what I've been able to do is reflect on what the team is focusing on," Miller said. "It's a situation where we want to be better on defense, we want to be accountable, and we want to make it easy on the goaltenders to play. Patty and I can read plays, we can sit back in our net, and we don't get caught out of position too often. It's a lot easier for goalies to play that way."'
The Sabres Report - October 25, 2008


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DPS Trooper Seizes over $408,000 in Meth
The Texas Department of Public Safety (DPS) conducted a traffic stop Thursday on IH-40, yielding over 11 pounds of methamphetamine valued over 408,000 dollars.
At approximately 1:32 p.m., a DPS trooper conducted a traffic stop on a 1999 Oldsmobile Alero traveling eastbound on IH-40, for a traffic violation, near Conway in Carson County.
For the full story SUBSCRIBE to the online edition of The Dalhart Texan, call 244-4511 to setup a subscription to our physical paper or pick a copy up at one of our many convenient newsrack locations. You can also stop by and purchase a paper or subscription in person at our news office located at 410 Denrock Ave.


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07967 423083
07544 971976
Welcome to Nordwalk, Nordic Walking in South Oxfordshire. Nordic walking is enhanced walking using two poles.
It's origins are based on the cross country ski technique, which Finnish athletes use for their summer training.
During the 90's, walking with poles became very popular all over Europe and the USA. In 1997 a Finnish pole
Manufacturer, Exel Oyj, produced the first Nordic Walking poles. The popularity of this activity, together with the
health benefits started to emerge, and in 2000, INWA (International Nordic Walking Federation) was formed.
Nordic walking poles differ from trekking poles. They are much lighter, thinner amd more flexible. The main difference
is the passive hand strap. This strap "connects" you to the pole, a fundamental part of the Nordic walking technique.
A trekking pole has a loop which fits loosely around the wrist. The whole process of Nordic walking involves a series
of synchronised movements which allows the technique to flow, this in turn automatically increases your walking speed,
all with less effort from you, as the poles do the walking.
May be you like the idea of getting or just keeping yourself a bit fitter, but perhaps conventional techniques like running, jogging or going to the gym just don't
appeal to you. If you want to try something different, in the great outdoors, this may be just what you need. Poles are provided for all walks if required.
Contact us for more information regarding the walks, an introduction to Nordic walking or anything to do with this activity, we would love to hear from you.
Fitness & fun rolled into one


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|22,668 sq. ft.
|Property type
|Minimum Stay
|4 nights
Our beautifully presented and equipped villa is situated within Tusan Ridge an airy development set adjacent to a breathtaking conservation area with plenty of foliage, water and wildlife around you. Disney is just a 15 min ride away up the I-4, we think this is the perfect location to enjoy all that central Florida has on offer.
Put some time aside to enjoy the villa in the daytime or evening enjoy the heated and illuminated pool and spa or just gaze over the conservation area and wildlife from the covered dining area or large sunny terrace.
Villa highlights:
4 bedrooms and 3 bathrooms.
Family room with large TV.
Totally separate reading room or quiet room
2 further TVs
1 DVD player.
1 CD player and docking station for Ipods or Iphones.
Free WiFi access throughout.
Phone service includes unlimited free calls within the US.
West facing pool with beautiful sunsets.
Full kitchen.
All linen and towels.
Washer & dryer.
Spacious double garage.
Front entrance porch with garden.
Nearby Golf at 'Reunion' (3 Miles): Nearby Golf at Highlands Reserve (2 miles).
Had lots of fun.
Nice house, enjoyed the pool and all the equipment.
Thanks for everything!
Very nice house to stay while we were in Orlando pool and hot tub however we were unaware we needed to pay $25 per day to heat it up. Although we had a lovely stay nice area and close to shops. Around 40 minutes to Disney but depends on traffic.
We thoroughly enjoyed our stay here. The villa was clean, nicely decorated and had everything we needed. The pool was lovely, had a nice view over the conservation area and wasn't overlooked. The location is great, very close to the parks with plenty of shops and restaurants nearby.
I cannot say enough about this fabulous home. It truly was like a home away from home.
The house was clean, well-appointed, well-maintained and the rental process was incredibly smooth and easy.
The home was spacious and very comfortable for our family of four. It was the perfect base for Disney, Universal or spring training baseball games (Dunedin or Kissimmee). We all spent every spare minute in the beautifully heated pool, swimming and watching the sun set over the naturalized area behind the house. We slept incredibly well in the very comfortable beds so we had plenty of energy to wake up and get to our activities the following day.
I will certainly recommend the Westles' Villa to all of my family and friends and look forward to the opportunity to return, hopefully next spring!
Thank you, Mr. and Mrs. Westle! It was a real pleasure!
We had a fantastic time at this beautiful villa. This is a spacious luxurious home with everything you need for a perfect holiday. It's position at the back of the community meant it was very peaceful and secluded but close to all the attractions. There are many supermarkets and restaurants close by. This is the perfect base to enjoy a wonderful stay in Florida. Would highly recommend.
Discover Tuscan Ridge and this luxurious villa located just 11 miles from Disney World, Florida. A short drive from Orlando Airport and less than one hour from the Atlantic or Gulf coast beaches, this villa is perfectly placed to enjoy the very best of all that central Florida has on offer from the frantic thrill of the major theme parks to the unhurried ambiance of coastal culture.
Tuscan Ridge is more than a community of unique villas, it is an extension of the member's home. In addition to the nearby celebrated golf courses at Highlands Reserve and Reunion, there is an extensive conservation area with wildlife and ponds.
The spacious and luxuriously equipped 4 bed, 3 bath villa with private pool and spa, sits seamlessly onto the conservation area and pond with fabulous views over the tree filled back drop. Truly, a setting of natural peace for yourself, family and friends.
|Rate Period
|Weekend Night
My Standard Rate
4 night minimum stay
|Cleaning Fee
|Refundable damage deposit
Your rental is charged at the rate of £85 per night plus a 'one off' cleaning fee of £85 per stay, (£170 for the first night and £85 per night thereafter).
Rates include US Federal & Florida State Taxes (12%).
Pool heating is an option available on request (recommended Oct-Apr) at an additional charge of £20 per day.


text:
If memory serves me right, Dany Nativel wrote:
> Is it possible to order the case from Soekris or is there any
> alternative solution besides the shoe box ?
I know (from reading the Web site and from having bought one) that you
can order a Soekris machine either as a bare board or mounted in the
case pictured on the Web site. For anything else, contact them.


text:
Homework Questions? Ask a Tutor for Answers ASAP
Hello rgauvin, would you quickly copy and paste what you have, I will add to it, and add sources, organize and proof it. I will wait for you to do this right now!
Thank you for your help.
What does American democracy mean to you as an individual?
As an individual, American democracy means my freedom in America. Freedom to do what I wish, choose my own religion, free to travel, and vote for whichever party I choose. I also have the ability to voice my own opinion. However, what I appreciate the most about democracy is freedom of speech. I can disagree with the leaders of this country without fear of being locked up or killed. Most importantly, American democracy means allowing people like myself to decide what is good for the country.
What are some of the criticisms of this style of government?
Some of the criticisms of this style of government are that other countries believe we should not have freedom. We should not be allowed to vote, go places when we want, or voice our own opinion. They believe that we should have to do what the government says. People in our country often take our freedom for granted and I strongly believe they should travel to places like Russia, or China to realize just how lucky we are.
You are welcome, I hope it helped!


text: On this day, the Chief of Air Force Advisory Committee approved the introduction of a new-look Service Dress uniform for RAAF personnel. The change involved replacing the then current blue-grey coloured uniform (adopted in 1972) with a dark blue shade, now called 'Air Force blue'. This was the same colour as the first RAAF uniform introduced into use early in 1922. The Service's senior officer at that time, Wing Commander (later Air Marshal Sir) Richard Williams, recounted in his memoirs of having found the colour during a visit to the Commonwealth Woollen Mills at Geelong, Victoria, where he observed serge material being dipped into indigo dye to produce navy blue. He liked the shade achieved one dip short of the required five, and chose that shade for the RAAF. The reintroduction of Air Force blue returned the RAAF to the distinctive colour of the Service's first 50 years.


text:
Learn and Connect
Office Hours
The Professional Services Category Team hosts monthly virtual office hours to address federal customer agency questions about professional services acquisitions. Office Hours cover a variety of professional services acquisition solutions and topics such as OASIS and OASIS Small Business, the Professional Services Schedule consolidation, Blanket Purchase Agreement evaluation factors, NAICS codes and set asides, and more.
"Office Hours" are open forum question and answer webinar sessions connecting contracting officers at federal customer agencies with GSA professional services contracting subject matter experts. Attendees can get answers to their questions to help them find the right contract solution for their complex professional services acquisition needs.
Professional Services Schedule Upcoming Events
View and register for upcoming events by visiting the Professional Services Category Interact Community
OASIS Training
FAI Training
DAU Training
GSA Schedules Training
Acquisition Gateway
Professional Services Interact Community
OASIS Interact Community


text:
Dub Fx and Opiuo Album Tour
Worldwide loop-station artist Dub FX and fun fuelled electro music genius Opiuo are making their way back to Auckland, April 12.
FuZen Entertainment couldn't pass up the chance to bring Northern Bass star Dub FX back to Auckland to celebrate the release of his new album "Theory of Harmony". Designed to take listeners on an eclectic journey through conscious, soulful bass music and drawing on inspiration from his endless performances worldwide the album stays true to the unique Dub FX live sound.
Funded by a wildly successful crowd funding campaign, the album features a host of collaborations with vocalists and musicians including Tiki Taane from NZ and Eva Lazarus from the UK. A video will be made for every song on the album and every song will be remixed from a list of A-class producers world wide.
Opiuo is New Zealand's own funky electronic wonder. With a new album due in March, Opiuo is never one to be stuck doing the same old thing. From a one man show equipped with drum machines and synths, all the way to the Opiuo band, amassing a collection of the world's best musicians to perform his music 100% live.
He's remixed world-renowned iconic artists from Kimbra to Pretty Lights, KOAN Sound to Infected Mushroom. Most recently his music was #1 on Hype Machine, ranking it the most popular song on the blogs.
Aucklanders need no introduction to our very own Buck Rogers! After a solid decade as drum and bass loving Bugsy, Buck Rogers was created to expand the record crate to incorporate all styles. From there it has been onwards and upwards for Buck Rogers moving on a voyage that will see explorations throughout all realms of electronic music incorporating Funk, Hip Hop, Glitch, Drum and Bass and Dubstep.
Dylan C is BaseFM's own Breakfast show host, DJ and Programme Director. While known for his down-tempo & hip hop sets, Dylan C also relishes the chance play a heavier sound, taking in everything from old school drum & bass and 90's trip-hop, through to future beats and deep dub-step flavours.


text:
CHANDIGARH:In yet another feather in the cap of the Chandigarh Administration, the Union Territory's Annapurna Akshaypatra Yojana (food for all at Rs 10) and the Kalam Express (school on wheels for children with special needs) are all set to go national.
Kangana Ranaut has finally broken her silence on the nepotism debate, which hit the headlines when Karan Johar, Saif Ali Khan and Varun Dhawan brought it up on the IIFA stage, and said she would be "a farmer" if the point about family genes were true.
Sandeep Rana
Tribune News Service
Chandigarh, July 16


text:
Hampton Township School District reading initiative honors Sandy Hook students
Groups around the world are joining in an effort to share the gift of reading with a child in honor of the students who were just learning to read at Sandy Hook Elementary School.
Hampton Township School District and community members are showing their support of the Newtown, Conn., community after the school shooting in December by collecting children's books through Sunday, Feb. 10, to donate to the high school's child-development class preschool program.
The collection is part of the We Can Read! initiative created by Slippery Rock University assistant professor Alice Del Vecchio along with the university's Student Nonprofit Alliance to encourage people to purchase a book, read it to a child and donate it to a school, child-care center or child-serving organization in their community.
"That was such a terrible day. It bothered me a lot," said Mary Beth Orbin, Hampton High School librarian who organized Hampton's collection. "It was the least I could do."
Orbin said she was "just a pair of hands" to organize the collection and has been touched by the community's support. Children's books have been brought in by teachers, staff, students, the student council, Rotary Interact club members and people in the community and line the top of the shelves of the high school's library.
"I think every book that shows up comes from somebody's heart," Orbin said.
"I hope they read it to a child or grandchild. It's not the number (of books collected), it's the sentiment."
This week, Orbin will deliver the books to the child-development classroom down the hall for the preschool students.
Melinda Jackson, family and consumer science teacher, said the books are a welcome gift to the program.
"It will be a great benefit to us to get all the books," Jackson said. "We have a lot of outdated items, so it will be nice to have new resources."
The Hampton High School students, who teach the preschool classes three days a week, read at least two books each day as part of the lesson plan.
"The variety (of books) allows us to incorporate more themes and ideas," Jackson said.
The books Hampton Township School District and the community collect also will be shared with the students and staff at Sandy Hook Elementary in the form of a Valentine's Day card, which Del Vecchio will send with the We Can Read! book collection totals.
"My hope would be that they know we think about them every day," Orbin said. "They're in our thoughts and prayers."
Bethany Hofstetter is a staff writer for Trib Total Media. She can be reached at 724-772-6364 or email@example.com.


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Mariano Gomes
Mariano Gomes (b. August 2, 1799 – d. February 17, 1872) was a Filipino priest and martyr, and an advocate of the secularization movement in the Philippines
Early life and education
Mariano was born in Sta. Cruz, Manila from a wealthy Filipino-Chinese family. He was first tutored by his father before his primary education at the San Jose College. At the age of 16, he earned a degree in philosophy then studied law at the University of Sto. Tomas. His parents were surprised by his sudden to be a priest. Eventually, he obtained his degree in theology with high honors.
Life as a clergy
Gomes officiated his first mass on May 28, 1824 and was appointed parish priest of Bacood, Cavite. As a Filipino priest, he was among those who believed that parishes should be secularized. He became instrumental in the surrender of Luis Parang to Spanish authorities.
Mariano founded the newspaper, La Verdad that exposed the abuses of the Spanish government and religious institutions. He also helped finance the Madrid publication of compatriot Fr. Jose Burgos defending the Filipino clergy.
Because of his principles and high regards to parishioners, Gomes was defended by the people of Bacood when he was about to be arrested by the Spaniards as a result of his implication in the Cavite Mutiny on January 20, 1872. Together with Burgos and Zamora, he was falsely accused of participating in the said mutiny.
Gomes, Burgos and Zamora (collectively known the Gomburza) was executed by means of garrote (strangulation) on February 17, 1872 at Bagumbayan (Luneta Park)
Last words
Fr. Mariano Gomes never signed his name with the Spanish letter "z" but with the Tagalog "s" as an act of resistance to Spaniards.
- Quirino, Carlos. Who's Who in Philippine History. Manila: Tahanan Books, 1995.
Original content from WikiPilipinas. under GNU Free Documentation License. See full disclaimer.


text:
|From: Robby Findler (robby at cs.uchicago.edu)
Date: Sat Apr 7 21:24:48 EDT 2007
(As a meta-point, I suspect that Matthew knows how to do these things, but that he hasn't found them to be profitable ... also the optimizer does iterate to a fixed point already, iiuc.) On 4/7/07, Dimitris Vyzovitis <vyzo at media.mit.edu> wrote: > > (comp=? (compile '(letrec ([f (lambda () 10)]) (display 2))) > > (compile '(display 2))) > > ; => #f > > ; because the optimizer is currently conservative about `letrec' > > Ok, letrec is trickier. With standard expansion to > (let ((f #<undefined>)) > (set! f (lambda () 10)) > ...) > > it may be possible to get rid of it with multiple passes, but it requires > safe mutation removal of sorts (the computation of the value in the > assingment has no direct side effects) This is not a correct expansion of letrec, I believe. There is some detail in the r5 report that I can't quite recall right now, but that expansion doesn't have the same behavior wrt call/cc as the spec in r5 does. I'm not sure if this has changed in r6 or not. Robby
|Posted on the users mailing list.


text:
This is the bug tracker for PyPI, not any individual package. Please contact the author of the package.
Issue #2 wontfix
Package download link does not exist and documentation incorrect for dataurl
The package described at the location below does not exist at the download location and no relevant documentation exists at the documetnation link.
Comments (2)
- changed status to wontfix
- Log in to comment


text:
Meaning of Title - An obvious reference Walt basking in praise from the other dealers at the opener, I think the reinforcement of Heisenberg!!!! in that scene also showed just how far Walt has come, so much to the point where he is cooking with Todd and killing his former partners.
Acting - Jonathan Banks who plays Mike had a great run on the series and his final line about wanting to die in peace was perfect.
1. MIND MELT MEGA SANDWICH RIGHT OUT THE GATE YO - Earlier in the episode Walt taunted Jesse by saying they were both doomed for their sins, which to my memory is one of the first times the show has acknowledged spiritual punishment for their actions, so right away my "this is some spiritual shit yo" detectors were going crazy. Having seen Mike earlier getting deep at the river, and casting aside elements of his earthly life (ie a lot of guns), and preparing for his trip (getting his go-bag) it was clear that he soon he would be making some kind of journey. And when he died sitting at the river surrounded by symbolism, my head exploded. Check out this passage about the Greek Underworld river journey.
The five rivers of Hades are Acheron (the river of sorrow) Having a good thing with Gus go wrong Cocytus (the river of lamentation) Not getting to say goodbye to your granddaughter, Phlegethon (the river of fire) See above imagery on water, Lethe (the river of forgetfulness) tough but case could be made about using about the sloppy Lawyer and Styx (the river of hate) Mike hates Walter, which forms the boundary between upper and lower worlds.2. To drive home this whole mythological quest when Walt confront Jesse on whole "you're damned to Burn" issue he was dressed in Red overalls and a black shirt. Fire and Brimstone! Forget Heisenberg, Walt is evil incarnate now.
3. Gotta love how many cell phones Saul has. Guess you could call them "saul phones?" Anybody? Anybody?
4. By invoking the "New York Yankees" and "Classic Coke" in his speech to the rival dealers/business partners, Walt has further proved that his story of a relentless quest for personal liberty and profit is an American tale just like those who came before him - Tony & Michael!
6. Again we get a dinner scene, with almost the same exact shot, but now Jesse isn't at the table. In fact Skylar doesn't even last long at the table before she leaves. This was a great visual hint about how all Walt's "allies" are abandoning him.
7. As sad as it was to see Mike go, I was bummed out by Walt's final actions, he should have blown Mike's brains all over that sun glazed river. Seeing him revert back to the bubbling, botched plan Walt was kind of depressing. If he's gonna be full on "say my name" evil then he needs to be all the way there by now. Having him realize he could have gotten the names from Lydia gave him a dash of fleeting humanity, and this point, there is no humanity left in him. I'm calling it now, if does have anything left, the thing that will snuff it out will be him killing Skylar.
8. Todd telling Walt he doesn't care about the money right now must be the most wonderful thing Walt has ever heard.
9. The impact of Walt's actions are huge because there is no way that Jesse wont' 100% know that Walt did it even if he tries to hide it. Even if he does admit to it, there is no way that Jesse will let that slide.
10. If Walt is keeping his meth supplies at the car wash, that's just sloppy and in fact everything Walt is doing now is sloppy. His killing of Mike, his cooking with a rookie like Todd, using the same sob routine to get the bug out, etc. Sloppy is the complete opposite of Gus Fring, the man who Walt wants to be. He wants to be in the empire business but he can't handle his own shit.
11. I miss Gus.
I'm going to be travelling next week so I won't have a blog up til Tuesday at the earliest, enjoy the finale!


text:
Investor Relations Websites
Click on a company name to visit the website. Where available, a direct link to the Investor Relations section of the company's website has been provided.
The company stock market symbol is noted in parentheses.
AGL Resources (GAS)
Allete (ALE)
Alliant Energy (LNT)
Ameren (AEE)
Atmos Energy (ATO)
Avista Corp. (AVA)
Black Hills Corp.(BKH)
CenterPoint Energy (CNP)
CH Energy Group, Inc. (CHG)
Cheniere Energy (LNG)
Chesapeake Utilities (CPK)
CMS Energy (CMS)
Consolidated Edison (ED)
Corning Natural Gas (CNIG.OB)
Delta Natural Gas (DGAS)
DTE Energy Co. (DTE)
Duke Energy Corp. (DUK)
Empire District Electric (EDE)
Enbridge (ENB)
Energen (EGN)
Energy Transfer Equity (ETE)
Entergy (ETR)
EQT Corp. (EQT)
Exelon (EXC)
Gas Natural (EGAS)
Integrys Energy Group (TEG)
Kinder Morgan (KMI)
Laclede Gas (LG)
MDU Resources (MDU)
MGE Energy (MGEE)
MidAmerican Energy (BRK-A)
National Fuel Gas Company (NFG)
National Grid (NGG)
New Jersey Resources (NJR)
NiSource Inc. (NI)
Northeast Utilities (NU)
NW Natural (NWN)
NV Energy (NVE)
ONEOK, Inc. (OKE)
PEPCO Holdings, Inc. (POM)
PG&E Corp. (PCG)
Piedmont Natural Gas (PNY)
PPL Resources (PPL)
Public Service Enterprises Group (PEG)
Questar (STR)
RGC Resources, Inc. (RGCO)
Sempra Energy (SRE)
South Jersey Industries (SJI)
Southwest Gas (SWX)
Spectra Energy (SE)
TECO Energy Inc. (TE)
Transcanada (TRP)
UGI Corp (UGI)
UIL Holdings (UIL)
Unitil (UTL)
UNS Energy (UNS)
Vectren Corp. (VVC)
WGL Holdings, Inc. (WGL)
Williams Companies, Inc. (WMB)
Wisconsin Energy Corp. (WEC)
Xcel Energy (XEL)


text:
Religious and cultural misunderstanding happen between people of many different backgrounds. So when I saw a minister had published that witches were dancing around pentagrams on brooms and laying on graves, I had to jump in. As many of my readers know, I live in a small rural Missouri town. It's so small, sometimes men [Read More…]
On Faith and Facts
November 4, 2011 by Guest Contributor Leave a Comment
Filed Under: Magick and Spirituality, Protecting Your Rights Tagged With: Christians, Col. Charles Vallency, cult, Druids, Evangelical, Fresh Fires USA, God, Godfrey Higgins, Halloween, occult, occult101.com, Ozark Regional Classifieds, Pagans, Pennysaver Shoppers Guide, religion, religious discrimination, Rodney Crewse, Samhain, Satan, Todd Bentley Leave a Comment


text:
Lyman-Morse has been recognized by the Maine Clean Boatyards and Marinas Program for the 6th year in a row. This year we have achieved our highest level of regonigition -- the Gold Level -- for our committment to reducing our footprint and using resources as responsibly as possible. In past years, we had been recognized at the Silver Level.
Gerry Tiernan, the Program Coordinator for the Maine Clean Boatyards and Marinas Program, remarked that "Lyman-Morse has gone above and beyond to create a green, more sustainable business. You are proof that integrating environmentally friendly policies that can actually benefit a business."
The recertification team was impressed with many of the systems that we have implemented including our solvent recycler, to the ZeroBase ReGenerators, and our green building.
The Gold Level was earned this year thanks in part to Lyman-Morse's new process of bottom washing boats, in which non of the residual material or water runoff is allowed to reenter the St. George River.


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SWTJC men and women both notched victories Tuesday night (Nov. 12) in San Antonio over the University of the Incarnate Word.
In the women's game, the Cowgirls posted a 66-25 win to boost their league record to 3-1. Leading scorers were Ashley Howell, 24 points; Chelsie Casiano, 15 points; and Aleah Bowers, 11 points.
The SWTJC men also cruised to victorywith a 99-56 win over UIW. Leading scorers were: Ben Luckey, 27 points; Cole Martinez, 24 points; and Mabior Mayen and Edwardo Robinson with 16 points each.
Next action for SWTJC teams will be on Wednesday, Nov. 20, at home against Victoria College.
Welcome to Southwest Texas Junior College, one of the top ten community colleges in the United States! More →


text:
"We're excited about the start of our season and for the chance to do what we all love to do, which is get in a gym, coach our players and train our team," said Fox. "So, this is a very exciting time of year for me, and I think our players give the indications that they¹re excited too."
Andy Landers begins his 31st season in Athens with record of 725-239. The Lady Bulldogs will welcome back four starters and two more letterwinners from a squad which finished 18-14 overall and lost in the first round of the 2009 NCAA Tournament.
"The beginning of practice is always an exciting time," Landers said. "That anticipation is probably even greater this year since we have more newcomers, seven, on our roster than returnees, six."


text:
Musicians find inspiration in all sorts of places.
Justin Bieber told reporters Monday night at a listening event in London for his Believe album (out June 19) that he wrote a song dedicated to the 20-year-old fan who claimed to have had the singer's baby after a tryst with the pop star in a backstage bathroom. She later dropped a paternity case against him and admitted her ex-boyfriend was the child's father.
"Like that girl -- Mariah Yeater -- who said she was going to have my baby," he said, reports BBC Newsbeat. "I wrote about that situation."
Bieber added that he's not sure that song will make the album.
"We've recorded like 40 songs," he said. "Every song has a piece of me, it's hard to pick. I wrote almost all of them or co-wrote them."
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Outdoor advertisment created by DDB, France for Tiji, within the category: Media.
Tiji TV as imaginative as children.
Creative Directors: Alexandre Hervé, Sylvain Thirache
Copywriter: Matthieu Elkaim
Artistic Director: Pierrette Diaz
Art Buyer: Marine Rolland
Advertiser's Supervisor: Thomas Granger
Account Supervisor: Michel Mimran
Peintre: Richard N'Go
Illustrator: Pierrette Diaz
This one is imaginative............. but not that imaginative!
I can just stare at this thing for hours and hours...
Simply heartwarming work!
I'm not familiar with the product, but the artwork is great. Hope it meets up with the concept!
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|The Mission Internship's Association is organizing with the Montlucon Association Saigon and the Red Cross of Vietnam, some internships in the hospital areas for: doctors, medical students, nurses IDE, students, nursing students, aides, midwives, dentists, hospital executives, etc…
Founded in 1993 by Olivier RODIEN, the Hoa Mai Orphanage assures accommodation, food and education of around 50 poor or orphaned children from 1 to 18 years old. Seven people work all year round in this structure: Director, Accountant, Service Personnel, etc…
|Despite the efforts of certain health authorities to develop a good level of care, there remains a lot to be done in a country ravaged by years of war. The Mission Internships Association and the Montlucon Association Saigon are combining their field of intervention in order to support the medical and human exchanges.
Our interns are accommodated at the orphanage and carry out their internships in a general hospital of around 300 beds. This hospital is situated in the city of Long Thanh, half way between Ho Chi Minh City (Saigon) and the sea of China. This establishment welcomes our French/English speaking interns (French, Swiss, Belgian, British, American etc) since 1996.
The interns will join the Vietnamese care teams in different service areas: maternity, emergencies, surgery, reanimation, traditional medicines, etc. They provide interpreters to facilitate their work.
|THE AMSbenefits from a long experience in the field and with the collaboration of the Red Cross it offers a professional package and assures the complete logistics of the internship in Vietnam (Welcome at the airport, transport, accommodation and meals at the Hoa Mai orphanage.)
Our aim is to create friendly relationships between Vietnamese and French care teams, to support technical exchanges like looking further into specific knowledge such as for example tropical diseases or traditional medicines.
It also offers Vietnamese cultural discovery (trips to the Mekong delta and/or on the littoral, visits of course to other medical establishments in Saigon)


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Ill Fated
Starring Paul Campbell, Peter Outerbridge, and Niki Clyne. Rated 18A. Opens Friday, June 3, at the Cinemark Tinseltown
It's a risky proposition to title a movie anything in the neighbourhood of Ill Fated-"Hey, honey, shall we go see SOL this weekend?" That's especially true when there's no money or marketing hooks behind the thing.
Unfortunately, the moviegoing experience for this Canadian film lives up-or down-to that title. A decent story, worthy cast, and out-of-the-way locations work hard to make up for grindingly sophomoric dialogue. Take out the F word and cowriter-director Mark A. Lewis's feature study of small-town bad manners becomes a short film.
Peter Outerbridge is memorable, if somewhat underused, as a fellow who sires two kids by different women, splits (sorry, I mean, fucks off), and then comes back when they are grown, unleashing harsh consequences. Likable young Paul Campbell as Jimmy is on-screen more, and to more consistent effect, as the man's similarly restless son. Also on hand are Niki Clyne as the local gal with whom Jimmy maybe shouldn't oughta be messin', if you know what we mean.
The film's tonal shifts from comedy to holy-shit drama are ambitious, in an overreaching, overpopulated sort of way, but they would have been more coherent if even one character could articulate, you know, something other than how pissed off they are at the world and probably at you, too. Ultimately, they all seem to have fates that few will want to share-especially at 10 bucks a friggin' pop.


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The English folklore character has been picked up by Warner Bros. Pictures with director Kevin Lima attached to helm the project.
"Tom Thumb" is springing up into the big screen. Warner Bros will produce the new 'Thumb' as live-action movie, although the character of Thumb will be brought to life with computer technology. This comedy-adventure will develop more on the heroism of the character than its original story.
"Enchanted" director Kevin Lima has been assigned by Warner Bros. to helm the project. The movie is originally adapted from a British legend dated back in the 1500s with the original screenplay penned by Robert Rodat, who has been buzzed for writing "Saving Private Ryan". Douglas Wick and Lucy Fisher will produce this movie via their Red Wagon banner, with Chris Chase sitting in the executive producer.
The story of "Tom Thumb" centers on an arrogant knight who shrinks to 6 inches while he is on the duty to protect a princess. The little hero is famous for getting himself into troubles with his family members and finally winding up in the kingdom of King Arthur. "Tom Thumb" actually has been filmed a few times over the years, including a live-action musical from MGM in 1958 and a darker animation from BBC Film in 1993.


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Packaging and Print Estimation
Presupuesto $250-750 USD
We are a packaging company specializing in paperboard and flexible packaging; Our focus in four market areas:
a) Pharmaceutical Packaging (Folding Carton/Labels)
b) Food and Beverage Packaging (Folding Food Cartons/Labels)
c) Beauty and Cosmetic (folding Cartons/Labels/ corrugated carton
d) Corrugated Boxes (only C,D,E Flute Boxes)
26 los freelancers están ofertando un promedio de $449 para este trabajo.
We are amongst top 1% global outsourcing providers. We have successfully finished over 430 projects in last 13 years. ID : 11798776 Greetings, We are interested to work on this project, please find my comments i Más
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Services of a professional and experienced designer are available who is expert in delivering quality and creative designs. Send me a text to start the discussion on your project.


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Invest NI will work with local stakeholders to try to develop a proposal for a £50m private sector 'Data Centre' promoted by the Londonderry One Plan.
Foyle SDLP MLA Colum Eastwood asked the Enterprise Minister Arlene Foster for her views on the proposal by way of an Assembly Question.
She replied: "As detailed in the One Plan itself, the opportunity and challenge is over a timeframe of 2-3 years with a funding requirement of around £50 million coming from the private sector."
She said that Northern Ireland currently does not have a significant or large scale colocation Data Centre.
The Minister said a small number of companies offer server space, which tends to be relatively small and limited.
She said that all major websites of Northern Ireland orgnisations are hosted via larger data centres in Dublin or Great Britain.
The Investment Minister continued: "Invest NI will continue to work with stakeholders to develop the local proposition and strengthen the ICT sector opportunity and encourage private sector Data Centre providers to consider suitable locations across Northern Ireland."


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harp, flute, and cello
Music to calm your soul
Our Bio
We were founded in 1985 when Kathy and I were studying for our masters degrees at the University of Cincinnati College-Conservatory of Music...
The Adagio Trio is available for weddings, receptions, and other events in the Cincinnati area. To inquire, you can use our Contact page or email Linda Grieser at email@example.com. For weddings in the Hampton Roads, Virginia area, you may contact the Galliard Trio (flute, violin, cello) at firstname.lastname@example.com.
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Police records room fraud cost Pittsburgh thousands
Lax supervision and shoddy financial controls in the Pittsburgh police records room could cost the city as much as $31,721, the city controller said in an audit released Thursday.
A part-time records room cashier took $17,140 in cash between Oct. 11, 2011 and Nov. 15, Controller Michael Lamb said. The city also stands to lose $14,581 in outdated checks the cashier failed to deposit because banks are unlikely to accept them now, Lamb said.
The cashier resigned in November after she admitted the theft. Police implemented tighter controls — some of which the audit now recommends — that include no longer accepting cash and ensuring that the person preparing deposit slips is not the same person taking them to the bank.
"There was an opportunity there to commit this fraud," Lamb said. "That opportunity should not have been there."
Police spokeswoman Diane Richard declined comment, citing a criminal investigation. Police and city officials have not identified the cashier.
Lamb, a Democratic candidate for mayor who as controller serves as the city's fiscal watchdog, said the police bureau's problems are not unique.
"This is something we know is a problem citywide," he said.
Joanna Doven, spokeswoman for Mayor Luke Ravenstahl, said police asked Lamb to conduct the audit and provide recommendations.
"The mayor looks forward to reviewing these recommendations and seeing them implemented," she said.
The biggest problem was that duties in the records room were not property segregated, Lamb said.
The city charges a fee for providing police reports. The cashier collects money, prepares revenue records and deposit slips, and takes money collected to the bank. No one double-checked to ensure that daily receipts matched daily bank deposits, the audit said.
Lamb said auditors found 3,714 checks that were not deposited, and speculated that the cashier was substituting them for cash she later received so amounts deposited matched amounts received.
"The person who is preparing the deposit slips should not be the person making the cash run," he said. "Segregating those duties eliminates the possibility of committing fraud."
Auditors found that two cashiers in the records room use a register that is not automated; deposits from the records room are not reconciled to the city accounting system; cashiers are not bonded; and voided transactions are not adequately documented or reviewed.
Police made a change, later recommended in the audit, to require people seeking copies of records to pay by check or money order. They also plan to begin reconciling accounts.
Lamb said they're still using an outdated cash register that cannot produce a daily record of receipts. He recommended that all city departments permit credit card payments.
"The key is that employees need to know that someone's looking," he said.
Bob Bauder is a staff writer for Trib Total Media. He can be reached at 412-765-2312 or email@example.com.


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Wedding Flowers Darwin
Everything you could need for the wedding of your dreams. From wedding planning tools, bomboniere and wedding stationery to guest books and table decorations.
Impress your guest with unique designer wedding flowers. Australia's most unique stunning wedding flowers, view our stunning bridal bouquets online now!.
Bridal bouquets Darwin - Wedding Flowers Darwin
Brides don't need to worry about matchmaking when it comes to wedding flowers. From the bridal bouquets Darwin to the boutonnieres, wedding flower trends include diversity of choice, boldness of colour and distinctiveness of design, according to a leading expert.
Working with a Florist on your Wedding Flowers Darwin and Bridal bouquets Darwin
For many brides, the most difficult wedding Flower decision can be finding the right florist. One of the biggest mistakes a bride can make is not entrusting a professional florist to design their wedding flowers. The touch of a good floral designer is unmistakable and will be reflected in the feel of the wedding ceremony
The best way to find the florist right for you is to ask friends and family for names of some florists they know and trust.
"Ultimately, you should select a florist whose style you like. Visit a number of florist shops to get a feel for their style, and once you think you've decided on a florist, have your fiancé send you flowers from the shop, and see if you like what arrives,"
The floral industry wants every bride's day to be perfect and offers helpful advice for brides-to-be.
Your Wedding Flowers Darwin and Bridal bouquets Darwin are an important part of your wedding day!
Choose a Darwin florist for your wedding flowers and bridal bouquets in Darwin are easy. Make sure your wedding flowers Darwin and bridal bouquets are perfect by selecting one of our wedding florists form our great range of Darwin wedding flowers and bridal bouquets suppliers.


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The Rapidan River near Ely's Ford. Union troops crossed here in late April 1863 in their attempt to sweep around and pinch
General Lee's Army of Northern Virginia between the segment of the Union Army led by General Hooker
and that commanded by General John Sedgwick along the Rappahannock River at Fredericksburg.
In early May, men in blue would retreat back across this river in defeat and disbelief.
Chancellorsville National Battlefield, Virginia.
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Home Plan Detail
Dune's Light
By: Ed Kriskywicz
Construction Design
Square FootageTotal living area: 2190' Basement: 3738' Main Level:1852' Upper Level:338' Basement:1548' Footprint: 56' 0" W x 49' 4" D
RoomsBedrooms: 2 Bathrooms: 2.0 Master suite location: Main Floor
AttributesLevels: 1 Parking: Garage Number of car stalls: 2 Foundation:
- Loft
- Large Deck
- Vaulted Ceiling
- Split-Level
- Fireplace
- Attic Storage
The vertical wood siding of this home is accented by timber elements and wood bracket details. Abundant glazing brings in plenty of sunlight to the interior spaces, and the use of stucco at the basement level helps to make it more economical to build.
This home was originally built on a sloped lot, so the entry is at mid–level, between the main and basement floors. After entering through the entry foyer, you go upstairs to the main floor. You enter a dining space, which is open to the kitchen. Two walls of windows line the kitchen, bringing in sunlight and views to the outdoor deck. An island sits in the middle of the kitchen, and has a raised bar for eating. To the right is a great room, which has a fireplace in one corner, and bays of windows that go up to the vaulted ceiling. A door from the great room leads to the outdoor deck. To the left of the dining area are a bedroom, a full bath, and a laundry room that connects to the garage. There is also a master bedroom suite, which has sliding glass doors that lead to the backyard deck. The master bathroom is spacious, and features a shower and a separate light–filled space for the tub.
From the entry there is a stairwell to the basement level. The partially finished basement has a third bedroom, a full bath, and a family room with a fireplace. There is also access to the unfinished basement, which may be used for mechanical equipment, or for storage.
From the main level, there is a stairwell to a loft space, which is open to the dining room and great room below. The loft also has access to the attic for extra storage space.
Floor Plans


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AC induction motors are ideal for most industrial and commercial applications because of their simple construction and less number of parts which reduce the maintenance cost. Induction motors are frequently used for both constant-speed and adjustable speed drive (ASD) applications.
The two basic parts of an induction motor are the stationary stator located in the motor frame and the rotor that is free to rotate with the motor shaft. Today's motor design and construction are highly refined. For example, stator and rotor laminations have been designed to achieve maximum magnetic density with minimum core losses and heating. The basic simplicity of this design ensures high efficiency and makes them easily adaptable to a variety of shapes and enclosures.
A three-phase induction motor can best be understood by examining the three-phase voltage source that powers the motor. Three-phase currents flowing in the motor establishes a rotating magnetic field in the stator coils. This magnetic field continuously pulsates across the air gap and into the rotor. As magnetic flux cuts across the rotor bars, a voltage is induced in them, similar to a voltage induced in the secondary winding of a transformer. As the rotor bars are part of a closed circuit (including the end rings), a current begins to circulate in them. The rotor current in turn produces a magnetic field that interacts with the magnetic field of the stator. Since this field is rotating and magnetically interlocked with the rotor, the rotor is dragged around with the stator field.
When there is no mechanical load on the motor shaft (no-load condition), the rotor almost manages to keep up with the synchronous speed of the rotating magnetic field in the stator coils. Drag from bearing friction and air resistance prevents perfect synchronism. As the load increases on the motor shaft, the actual speed of the rotor tends to fall further behind the speed of the rotating magnetic field in the stator. This difference in speed causes more magnetic lines to be cut, resulting in more torque being developed in the rotor and delivered to the shaft mechanical load. The rotor always turns at the exact speed necessary to produce the torque required to meet the load placed on the motor shaft at that moment of time. This is usually a dynamic situation, with the motor shaft speed constantly changing slightly to accommodate minor variations in load.
The rotor consists of copper or aluminum bars connected together at the ends with heavy rings. The construction is similar to that of a squirrel cage, a term often used to describe this type of AC induction motor.
The squirrel cage induction motor is most commonly used because of the following reasons
Motors rated from 0.1 kW to 2500 kW in low voltage range can be used with Soft Starters. To select the right Soft Starter please check our design center section of the website.
for the motors ranging from 25kW onwards in 3.3/6.6/11 kV range, the HFSR soft starters is the best match.


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Yup, you read that right, the classic Atari game Space Invaders is on the fast track to becoming a major motion picture. According to the LA Times one studio is currently acquiring the rights to the game in an attempt to bring it to the big screen:
Warner Bros. is negotiating to acquire feature rights to the landmark shooter from Taito, the Japanese company that originally manufactured the game. If the rights issues all work out, the project would bring on Hollywood fixtures Mark Gordon, Jason Blum and Guymon Casady as producers.
Space Invaders is not the only classic game in consideration at the moment either. As we reported in February a movie version of Missile Command is also in the works. All I can say is that I hope John Leguizamo (the king of classic gaming movies imho) is in this sucker. The method acting he brought to Super Mario Brothers would have brought a tear to Lee Strasberg's eye.
(via ScifiWire)


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Do It Yourself PatternsApril 10th, 2012
Building your own deck can be a little more advanced landscaping project. Hair and nails are two locations of the physique that require a bit of care to look good. To design glass tile mosaic patterns by drawing, it is best to use graph paper (also known as grid paper because the paper is covered in lines that make a grid). A blog for easy to do nail art designs, pretty nail polish swatches, and everything in between. This page shows you examples of various tile patterns and styles. To help determine the perfect style to fit the flow of your home or business. Do It Yourself Wood Projects and Woodworking Plans, Building outdoor backyard and garden projects around the house and home, Wood Craft Plans.
Do It Yourself Patterns
- Wikipedia has a comprehensive list of camouflage patterns, and the nations that use them.
- Do It Yourself Gifts Guide to Glass Etching.
- Custom do it yourself binders with fast shipping.
- Choose from thousands of do it yourself 3 ring binder designs in the Zazzle Marketplace.
- Get step-by-step project ideas for home accents and room makeovers you can do yourself.
- Wood working plans, projects and patterns for do-it-yourself woodworkers of all wood working skill levels from U-Bild.
More information about Do It Yourself Patterns on the site: http://www.do-it-yourself-gifts.com


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