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By Andrew Z
Jul 22, 2013
|FYI: Looking at the photo of B-G Crack. Gary Isaacs and I did the first ascent. I can't remember the year (early '70s?). He led I followed. Gary decided to name it Bat Guano Crack. It came out in the guide as B-G Crack without anyone consulting Gary.
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A photo of pickled veggies used in a story about food freedom on Transition Voice, the peak oil magazine, http://transitionvoice.com.
About Lindsay Curren
Lindsay Curren is Editor-in-Chief of Transition Voice, the online magazine on peak oil. She also does art and essays at Lindsay Curren Handmade Prints. Follow her on Twitter @Lindsay Current.

subset: commoncrawl


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I am an Academy Research Fellow working in the Trends and Tensions in Intellectual Integration project (TINT), now Academy of Finland Centre of Excellence in the Philosophy of the Social Sciences, University of Helsinki.
Previously I was a Post-Doctoral fellow at the Faculty of Philosophy of the Erasmus University of Rotterdam. I obtained my PhD at the Erasmus Institute for Philosophy and Economics (EIPE), Erasmus University of Rotterdam.
My research interests are in the philosophy and methodology of economics and in the philosophy of the social sciences. I am currently Associate Editor of the Journal of Economic Methodology.


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He is the seventh UNMC faculty member to win the OTICA since it was first handed out in 1992.
|Watch a video about Dr. MacDonald.
He has:
- Won UNMC's Outstanding Teacher of the Year award three times;
- Developed new courses; and
- Routinely receives high evaluations from his students.
Dr. MacDonald uses an innovative teaching style that incorporates 21st century tools and goals in a multidisciplinary environment to fully engage medical and graduate students.
Below he answers a few questions about his teaching style.
How do you keep your students engaged and excited about what they are learning?
My mentors in education taught me to always keep the message simple and relevant. For medical students, this means focusing the material on what is essential to understand the pathophysiology of disease. For graduate students, this manifests in application of the material.
What do you do to stay current in your field and how do you incorporate that into the curriculum you teach?
I read literature both in my research area and in the broader areas that I teach, always looking for new information and useful ways to make classical chemical principles relevant to modern biology. I also keep up with the latest editions of biochemistry, cancer and cellular biology, and physiology textbooks to keep tabs on what newer topics have been incorporated as textbook-level knowledge.
Thank you, your comment will appear below once it has been approved.


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It's the 3rd Annual Charity Steak Cookoff at FRESH
Join FRESH this Saturday, May 4th for the Third Annual Charity Steak Cookoff benefiting the East Texas Food Bank. The Cookoff and festivities will begin at 3 p.m. at FRESH as local businesses, media outlets and foodies will face off in hopes of wrangling the "Ace of Steaks" championship belt. Round up the whole gang for an afternoon of fun featuring family games, the Freshpet ® Strut Your Mutt contest and Freshpet ® Yippee dog races, a Classic, Hot Rod and Custom Car Show, live music from Stephan Cotter and the C Otters and the Steve Simmons Band.


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Hardware as a Service
Affordable hardware and operating systems without the headaches
Hardware as a Service programs from OmicronWave Technologies are an effective way to ease your frustrations from the regular need for new equipment and operating systems and its effect on your budget.
With a flat monthly fee for equipment and warranty service, we eliminate large capital outlays and allow IT equipment costs and related maintenance services to qualify as operating expenses, providing you with significant tax advantages.
Let us bring predictability to your expenses as well as your revenue and profits.
Contact us today.
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We provide a range of Computer Support, Network Services, Computer Repairs and IT Consulting in Denton, Lewisville, Dallas, Frisco, Plano, Richardson, Irving, Arlington and Dallas-Fort Worth Area.
Local experts who can visit on-site: Denton Computer Support, Lewisville Network Services, Dallas Backup and Data Recovery, Denton IT Consulting , Lewisville Cloud Computing, Dallas VoIP and Phone Systems, Denton Virturalization, Lewisville Email and Spam Protection, Dallas Computer Hardware, Denton Hosted Software, Lewisville Network Services, Dallas Microsoft Office 365, Richardson Network Services and Plano Computer Support.


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Looking for recommendations: fantasy or scifi that's not too dreary
View Single Post
Jeffrey A. Carver
Posts: 1,350
Karma: 1107383
Join Date: Aug 2008
Location: Massachusetts, USA
Device: Galaxy Tab 10.1, Nook HD+, and Windows Phone
My stuff isn't the least bit dreary; it's probably closest in spirit to the Bujold books. You could start with my new backlist omnibus
Dragon Space
, which is science fiction that involves dragons, or for harder SF (with humor)
The Chaos Chronicles
, which is a series that's up to four books now, and I'm working on the fifth. (Free samples available.)
I too love Bujold's work; also Joe Haldeman, Joan Vinge, Vonda McIntyre, Vernor Vinge (excellent, though he can get a little dark), Diane Duane (especially her Wizardry series). Geez, who else? I actually have a
recommended reading list
, which I created because my mind always went blank when people asked me who my favorite authors were.
That effectively ends at about ten years ago, though, because I can't keep up with the newer stuff, and frankly, a lot of it is too dreary for my tastes.
Oh--Terry Bisson's
Bears Discover Fire
is a great story collection. Also, short fiction by Geoff Landis and Connie Willis. And Spider Robinson. Craig Shaw Gardner has written a lot of funny fantasy (A Malady of Magicks, etc.), but they're not in ebook yet (I'm leaning on him about that).
Have you read Cordwainer Smith? He's from the classic era, but his stories are wonderful and quirky (and available in a couple of omnibuses from Baen).
Oh--Julie Czerneda, for SF rooted in biology and I guess anthropology. And for light reading, my wife loves the SF romances of Sharon Lee and Steve Miller (haven't read them myself).
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With debate about NSA spying continuing in the Senate, it's worth looking at some of the historical and modern precedents for protecting our communications and communications data. A few highlights:
- The earliest precedent for protection of communications in the United States is the treatment of mail. The founders used postal mail to communicate their revolutionary ideas and even to plan their insurrection against the tyranny of King George, so they prioritized protecting the privacy of the mail. In the Act of Feb. 20, 1792, passed a few short years after ratification of the Constitution, the U.S. Congress enshrined protections for mail in the law, creating heavy fines for opening or delaying mail.
- The Supreme Court confirmed the existence of constitutional protection for postal communications in Ex Parte Jackson. In that 1877 case, the Court described the Fourth Amendment's guarantees in very interesting and clear language: "Letters and sealed packages … are as fully guarded from examination and inspection, except as to their outward form and weight, as if they were retained by the parties forwarding them in their own domiciles." Though we place mail in the hands of government agents, the Fourth Amendment protects it like it's inside our homes.
- The year Ex Parte Jackson case was decided, both Western Union and the Bell Company began providing voice telephone service. The Supreme Court addressed constitutional protection for phone calls some decades later in 1928. The Olmstead case was wrongly decided, we now know. It found that telephone communications weren't protected by the Constitution. So the dissents are where to look for precedential language. Justice Brandeis's famous dissent spoke of the "right to be let alone," but Justice Butler provided thinking and language that should have more lasting value: "The contracts between telephone companies and users contemplate the private use of the facilities employed in the service," he wrote. "The communications belong to the parties between whom they pass." The communications belong to the parties. That's a fasacinating and important way to think about our communications, as property that we own.


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Does Community Composition or Environmental Variability Control Extracellular Enzyme Activity in Soil? A Spatial Analysis in a Complex Forested Landscape., Leaf Litter Diversity Effects On Microbial Functional and Taxonomic Profiles., Measuring the Complexity of Fine Root Systems at the Population and Community Levels in a Temperate Forest.
Elevated Carbon Dioxide and Ozone Effects On Above- and Belowground Growth and Decomposition in a No-till Soybean-Wheat System., Influences of Rising Atmospheric Carbon Dioxide and Ozone Concentrations On Soil Respiration, Soil Microbial Biomass, Nutrient Availability and Soil C Dynamics in a Soybean-Wheat No-till System.
Trichloroacetic Acid Extractable N and P as Indicators of Site Quality Changes in Pine Plantations in the South., Belowground C Allocation Varies Among Clones of Loblolly Pine., Nitrogen, Phosphorus and Carbon Transformation in Deep Row Biosolids Incorporation for Hybrid Poplar Production in Coastal Plain Mine Reclamation Sites in Virginia., Identifying Colluvial Deposits in the Ridge and Valley Using Changes in Topography and Species Composition to Improve Estimates of Forest Site Quality., Dissolution of the Mineral Surface and P Release by Mehlich 3 Soil Tests Determined by Ligand-Desorbable Fe and Al.
Use of Crop Models for Climate-Agricultural Decisions., Extension and the Climate Change Challenge: Providing Climate Services to Citizens and Communities., SISALERT - A Methodological Aproach for Decision Making On Plant Disease Management., Using Climate Information to Minimise Agricultural Risk with a Focus On Crop Disease Management: a Collaboration Among Australia, USA and Brazil.
BEAREX_08 Eddy Covariance Intercomparison., Evaluating Flux-Variance Relationships Under Strongly Advective Conditions During BEAREX08., Comparison of Turbulent Statistics and Spectral Characteristics Under Strong Advective Conditions., Improving Crop Model Simulations by Assimilating Leaf Area Index Estimated From Canopy Spectral Reflectance.
Reducing NH3 Emissions From Australian Agriculture with the Urease Inhibitor NBPT., Potential of the Nitrification Inhibitor DMPP for Reducing Nitrification and N2o Emissions From Australian Agricultural Soils., Influence of Temperature and Soil Type On Inhibition of Urea Hydrolysis by the Urease Inhibitor NBPT in Australian Soils.


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Todd D. Volz wrote:
> ----- "Todd D. Volz" wrote:
>> I have an Alix 2c1 (3/1/128/LX700) (0.99B firmware) board running m0n0wall 1.3b10 and it is
>> The system doesn't actually reboot on it's own, it is triggered by logging into the web
interface, after the authentication is passed, the web browser does not show the web interface it
just hangs, the firewall stops responding to pings. When ping responses return, I retry access to
the web interface and see that the uptime is 0:00.
>> When the system has been up for a few days (1 - 5) I notice that some systems on my network
aren't able to reach the Internet anymore so I try to access the web interface to see if there are
any problems, and get the above symptoms/results.
>> I have tried the same config on two separate boards running the same version of m0n0wall with
both having the same problem.
>> My last reload was this morning at 7:34 AM (per uptime and internal logs on router)
>> I have captured the syslog logs, however they don't appear to be very helpful (You can look at
those at http://maya.stir.org/smokey-200804-07.log )
>> I have captured the on device logs from the system log tab
(http://maya.stir.org/smokey-200804-07-ondevice.log )
>> I have also captured and sanitized (I hope not making it too unreadable) the status.php
>> I have a total of 5 pcs and 10 - 15 other devices that may access the Internet.
>> I use one machine to pull SNMP network statistics from devices outside the firewall (approx. 200
devices) and also use that same machine as a public DNS server, so it gets and makes quite a few
>> WAN interface has a static public IP address. (I also have a second public IP that I use via
proxy arp)
>> LAN I do not run a DHCP server from monowall (provided by an internal server)
>> Opt 1 runs a DHCP server for a Wireless network
>> Opt 2 is the same network as WAN, however has a different IP address (you will notice messages in
the logs stating that ARP requests are comming back from the wrong interfaces). I do this as I need
the public network to perform the SNMP monitoring.
>> IPSEC1 is disabled.
>> The second IPSEC tunnel is to a m0n0 pc running 1.22
>> The third IPSEC tunnel is to an m0n0 running on an Alix 2c1 version 1.3b10
>> Any ideas on why this box is rebooting?
>> If there is any more information that would be helpful let me know and I will provide what I can.
>> Thanks for any help.
>> Todd
> Does anyone have experience with this Alix 2c1 running reliably?
> What are the features of monowall that you use with the Alix 2c1? (VLAN, IPSEC, 1:1 NAT, proxy
arp, etc)
> Is there a way to turn logging on on the console connection so that I might be able to capture any
errors before it reboots?
> Thanks
> Todd
See my post
Date: 03/19/08
Subject: m0n0wall on WRAP/ALIX spontaneously rebooting
I have seen some strangeness, but it was not only on ALIX, it was also
occurring on WRAP...
Bill Arlofski


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Fleet Feet Sports' YMCA Charity Fun Run/Walk
Burbank Community YMCA
Saturday, July 20, 2013 from 9:30 AM to 1:00 PM (PDT)
Who's Going
San Francisco, California
London, United Kingdom
Florence, Italy
Event Details
When & Where
Fleet Feet Sports Burbank
1515 W Magnolia Blvd
Saturday, July 20, 2013 from 9:30 AM to 1:00 PM (PDT)
Add to my calendar
Burbank Community YMCA
The Burbank Community Y has been at the heart of our community since 1924. We've been listening and responding to our members, friends and neighbors needs for nearly 90 years.
We believe that all kids deserve the opportunity to discover who they are and what they can achieve. We are the leading voice on health and well-being for all. And we are committed to giving back, providing support and responding to our community, our city, and our country's most critical social needs.
As a result, countless numbers of youth, adults and families are receiving the guidance and resources they need to achieve greater health and well being. Let's all grow, learn and thrive together.


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Israel Is Back
Why would a thriving, diverse and boisterous Jewish community with a large Israeli population forgo an annual festival that celebrates the birth of Israel? As unlikely as it sounds, this is precisely what happened last year: For the first time in more than 20 years, the Israel Independence Day Festival that had become a signature event for our community got canceled.
As much as people had their usual complaints about the festival — too far, too hot, too loud, too cheesy, too Jewish, not Jewish enough — its absence left a big hole in our community. It was the one occasion each year when you could really experience the wild and quirky diversity of the Jewish world in greater Los Angeles.
So, why was it canceled? The official answer is money. The City of Los Angeles, citing budget constraints, decided that the festival needed to cover the costs for police, fire and traffic services, which the city once picked up. And at the same time, some previous backers opted not to make their usual contributions.
If you ask me, though, I think it was about more than money. The festival was getting tired and predictable. It had lost its spark. These days, if you want thousands of people to show up for your event, you'd better make it worth their shlep. Let's face it: It's a lot easier to experience a virtual Facebook community in your pajamas — and join fan pages, share photos and YouTube clips and post clever comments — than it is to brave traffic and the heat to show your support for a cause.
And when people do show up, the cool thing now is not to celebrate but to "occupy." Protesting is so much more dramatic than is just celebrating.
The point is, reviving a tired festival is no easy task. Anyone taking on the challenge would have to give the event a major upgrade — or at least a fresh twist.
Enter Naty Saidoff and the Israeli Leadership Council (ILC).
At a meeting last fall, the ILC board had a difficult debate about whether it would, or could, undertake the huge challenge of helping to resuscitate the festival. Finally, with Saidoff pledging a major financial commitment, the board decided it would seek partners and get behind the project.
Thus began an adrenaline-filled chain of events and strategic partnerships that have led to our own little community miracle: the revival and reincarnation of the Israel Independence Day Festival, which will be held on Sunday, April 29, at Rancho Park in Cheviot Hills.
The festivities will kick off at 9 a.m. with a march from the park down Pico Boulevard to The Museum of Tolerance, then back to the park. Festival activities run from 10 a.m. until 6 p.m. All information, including ticketing, can easily be accessed on the Web site (celebrateisraelfestival.com).
Will this new incarnation of the festival be a hit, and will it create a successful model for future years?
Well, let's start with the important stuff: parking. According to the organizers, parking will be a lot smoother and easier than at the previous location at Woodley Park in Van Nuys, where I distinctly recall feeling like my ancestors in the Sinai desert as I trekked with my little tribe from the car to the festival grounds.
Beyond the parking, the organizers have taken a whole different approach to the festival experience. Yes, there will be the traditional booths — more than 150 of them, covering the broad spectrum of Jewish life in our community — and there will be plenty of entertainment, headlined by Israeli star Eyal Golan, local star Craig Taubman, television star Monique Benabou (from the show "The Voice") and, among many others, the klezmex Ellis Island Band from New York (which combines — no joke — klezmer and mariachi).
And yes, there will also be prominent speakers and lots of food venues and plenty of entertainment and rides for the kids.
But beyond all that, here's what I think is the real innovation this year: themed pavilions.
These pavilions will be little worlds unto themselves that will celebrate different areas of Israeli and Jewish life. You can get specific information on the festival Web site, but just to give you an idea, these are some of the themes that will be explored: the wonders of Israeli technology, the depth and meaning of spirituality, the world of art and sculpture, the mystery of genealogy and, not least, Israeli joie de vivre.
Yes, joie de vivre. The organizers figured that after you celebrate the wonders of Israel, it might be a good idea to celebrate life itself. So, one of the pavilions will be called Café Tel Aviv, which will feature a hummus bar, Israeli DJs and, the organizers promise, a "real Tel Aviv ambiance."
I asked Saidoff over coffee last week what made him push so hard to help bring back the festival. "We found amazing partners all over the community," he told me. "We couldn't have done it otherwise."
But before we parted, he also added: "With everything that's happening in Israel right now, and with all the pressure the country is under, how could we not do this?"
Saidoff is right: How could we not do this? How could we not celebrate the continuing miracle of Israel's existence? And how could we not allow for at least one day a year when we could all connect as a community and see each other in real time and in real life?
The Israel festival is back, and for one day at least, Facebook can wait. On April 29, we should all journey to Rancho Park and occupy celebration.
David Suissa is president of TRIBE Media Corp./Jewish Journal and can be reached at firstname.lastname@example.com.


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Gold Leaf Sconces
Carved wood wall featured on our website are hand made in Firenze (Italy). All sconces made following the antique artisans traditions. Wall sconces carefully carved in wood before being finished by hand using real gold leaf of the finest quality.
Gold-leafing Process
Experienced artisans who created this magnificent sconces are deeply knowledgeable in gold-leafing process. During this process real gold is pounded to create wafer thin sheets of gold. This sheets are than applied with the utmost care and special glue to the carved wood sconces. Because sheets are so thin, they must be carefully handled or they will disintegrate when touched. This is a very skillful and time consuming process


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Frayed Knights - Extremely limited 50% Off
If you are extremely quick (and possibly lucky) Rampant Games is offering a 50% off discount code for Frayed Knights -- but there are only 41 of these discounts available. They may even all be gone for all I know, so if you are interested…
More information.
Thanks, Dhruin! I hadn't picked this up yet and got the discount!
Snatched one.
And I wanted something to do before Skyrim too.
Thanks Dhruin.
They are all gone now. Glad some RPGWatch members were able to snag some!
I was too late. I'll wait for another sale or Steam debut or Humble Bundle down the line etc.
Yes I am cheap these days but I'm trying to get some bills down and I very rarely pay full price for anything. :p
This game is worth the full price!! :)
I'm not saying this or any game is not worth the full price, $20 isn't that much, it's just hard for me personally to justify paying full price.
I've downloaded and played through the first dungeon and am in the first town. The dungeon was short, but seems longer due to the tedious walking speed. I'm going to have to see if I can tweak that, or it'll drive me nuts. Also, I seem to be looking about a foot to a foot and a half higher up than in most games. That's a little weird too, but I can learn to deal with it.(Duh, the camera moves!) The game feels like Minions of Mirth to me. The humor isn't doing anything for me, but I didn't expect it to.
I probably would have paid full price, eventually. This just made the purchase happen sooner. There does seem to be a lot of quests in the first town. Most of them "seem" to be very standard quests, but time will tell.
Heh - I get the same way. Too many games, no time to play them (especially with FK's development over the last *cough*fouryears*cough*). What's funny for me is often the "must-buys" these days, when they are new, are the indie games. I'm willing to wait a while for a lot of the big-name titles.
BTW, don't hold your breath on Steam. It ain't happening. Got the official word today. I'm in fine company with Vic Davis and Steven Peeler, and I wasn't really counting on it, so it's no big. FK is something of a niche title - I intended that from the get go. I'm hoping the niche is large enough to make it worthwhile, of course. :) But it's really geared for a particular audience. I don't know how to reach 'em all, so please… spread the word to those you may know. Have them play the demo, at least. :) It's free, and is a pretty good indicator for what the rest of the game is about ('cept for the fact combat and character development gets progressively more detailed).
What about GamersGate, Impulse, D2D and why not give Origin a shot (although I hate Origin with a passion, it couldn't hurt to try)?
GamersGate has some very niche games on it. I can't see why they would turn you down unlike those snobs over at Steam.
Too bad about steam. Not unexpected though. Graphically it is just not good (or stylish) enough to appeal to a mainstream audience. I hope you find your audience anyway, RC.
The graphics in FK are very fuzzy. Almost no detail on anything. That's gotta throw some folks off. I could care less. I think the graphics do the job well enough to set up the game play. It looks like the big selling point of the game is going to be character building.
Also, I got my first laugh out of the game last night in the "Farmer Bob" quest. That was well done :D I'm going to start over though. Endurance seems to be KEY and I didn't take endurance for anyone in the first couple levels. The little blond does about one thing and then keels over. She's been pretty much useless, so I need to bump her endurance for sure. The dreadlock dude is pretty useless too, his spell selection sucks. I'm going to dual him to a combat role and let the thief pick up a cleric role. I believe I'll keep the warrior girl single-classed; at least for several levels.
Those who have finished can let me know if these are terrible choices.
I'm enjoying Cthulhu Saves the World right now I got from Steam.
Those graphics are over the top!
Jay, what's it going to take for them to change their minds? Proven sales? Willingness to put it in the $3.50 bin?
I've been holding off on continuing FK until that update is out. Y'now the one with a hotkey for the UI toggle and the having the mouse mapped for movement that I asked for. ;)
I hope we get a patch that addresses the game window closing constantly when you click the mouse. That's driving me insane(r). Of course, there's probably a workaround that I don't know about. Hint, hint…..
Supposedly Steam told the creator of Gemini Rue his game was too low res and yet someone there change their minds and now it's up.
I have a hard time buying it's strictly graphics considering some other selections that are up on there. I'm sure they have their criteria by I don't know what it is and don't always understand why game x made it and game y didn't.
Cool! I restarted tonight and have done the starter dungeon, Farmer Bob's and retrieved something the mayor wanted. I also did a couple of little quest where you never leave town. So far, there isn't any loot to speak about. The magic girl can still cast one decent spell before being wiped out stamina-wise. Also, she seems to need some incredibly rare stones to cast anything higher than a 2 damage spell. I've got to get her some levels I guess.
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Welcome to the Sherlock Wiki (TV Series) Wiki
The Sherlock Wiki (TV Series) Wiki is a wiki based around the 2010-present series by Steven Moffat and Mark Gatiss based on the original Sherlock Holmes stories! It is viewed on BBC and there has been about two season's so far.
- For detailed information, Visit: BBC Sherlock Wiki
What is Sherlock?Edit
Sherlock is based on the original series of books. It shows Sherlock and Watson's struggles against the most deadly crimes- but this time, in the 21st Century.
Latest activityEdit
- Talk:Sherlock Holmes
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Comment: Loving it
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Dr Kirsten Jackson BSc BVMS(Hons) MANZCVSC (Eq Dent) CMAVA
Equine Dental Veterinarian
Give your horse a professional equine dentistry treatment.
Dr Kirsten Jackson of DentalVet provides horse dentistry services to Perth, Western Australia. She is also a qualified veterinarian with experience in equine medicine and surgery.
With DentalVet, you can be confident that your horse is in qualified, experienced hands.
0439 956 368
"Dr Jackson did such a great job with my horse Nudge. She was punctual, professional and very thorough. You can see and feel the difference and I know that he is much more comfortable now without those sharp points and hooks!" – Rebecca Taylor, Keysbrook
"Thanks so much for the great care you showed both our horses. We also learned so much from your visit! As new horse owners it is lovely for us to meet people that inspire our confidence!" - Jaala, Eloise and Lauren Demarti


text:
Reproduction is permitted for noncommercial purposes.
Ginkgolide B, the major active component of
Ginkgolide B, the major component of extracts from leaves of
Apoptosis plays an important role in the embryogenesis and homeostasis of multi-cellular organisms, and impairment of apoptotic function has been associated with several human diseases, including neurodegenerative disorders and cancer [
To elucidate the precise regulatory mechanisms of ginkgolide B-triggered cytotoxicity, we examined the effects of ginkgolide B on human breast cancer MCF-7 cells. Our results revealed that ginkgolide B treatment triggers apoptotic biochemical changes such as oxidative stress generation, Ca2+ influx, NO production, loss of MMP, increased P53 and P21 expression levels, and caspase-9/-3 activation in MCF-7 cells.
MCF-7 cells were incubated with various doses of ginkgolide B, and cell viability was determined. Our results revealed that cell viability decreases in response to dose-dependent treatment of 5 to 80 μM ginkgolide B (
Since our previous studies demonstrated that numerous stimuli can trigger cell apoptosis via ROS generation [
Changes in intracellular Ca2+ concentration ([Ca2+]i) in ginkgolide B-treated MCF-7 were detected using the Fluo-3AM fluorescence dye. We found that treatment with ginkgolide B elicited an increase in [Ca2+]i (
We next analyzed MMP change, a major apoptotic event during mitochondrial-mediated apoptotic processes [
The results from our real-time RT-PCR analyses showed that p53 and p21 were significantly up-regulated at the mRNA levels in MCF-7 cells treated with ginkgolide B, but these changes could be blocked by pretreatment with NAC or PTIO (
To further determine the role of p53 in ginkgolide B-induced apoptosis, we used targeted siRNAs to decrease the expression levels of p53 in MCF-7 cells, and then incubated the cells with ginkgolide B for 24 h and tested for cell viability. The siRNA knockdown significantly decreased the protein expression levels (data not shown) and mRNA levels of p53 and p21 (
Previous reports showed that
Importantly, ginkgolide B directly induces oxidative stress generation in MCF-7 in our experiments (
Mitochondria act as important conduits for signals during programmed cell death, and loss of mitochondrial integrity is promoted or inhibited by many key regulators of apoptosis [
Previous studies have shown that increases in intracellular calcium levels can play an important role in regulating cell death [
NO is a product produced endogenously from NADPH, O2 and L-arginine catalyzed by nitric oxide synthase. A recent study demonstrated that NO production was involved in apoptosis triggered by several different types of stimuli [
It is well known that NO-mediated apoptotic processes are associated with p53 gene activation, which is essential for regulation of cell cycle and/or apoptotic signaling occurring through p21Waf1/Cip1 or Bax [
The studies have shown that ginkgolide B can both stimulate and inhibit apoptotic signaling. Our previous study revealed that 5–10 μM ginkgolide B treatment of embryonic stem (ESC-B5) cells induced apoptosis via ROS generation, JNK activation, loss of mitochondrial membrane potential and activation of caspase-3 [
Based on the results of the present study, we propose a possible model of ginkgolide B-induced cell apoptosis signaling in MCF-7 cells (
Ginkgolide B, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), 2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide (PTIO), N-acetyl cysteine (NAC), α-tocopherol, 2′,7′-dichlorofluorescein diacetate (DCF-DA), propidium iodide, Hoechst 33342, ethyleneglycol-bis(β-aminoethylether)tetraacetic acid (EGTA) and Dulbecco's modified Eagle's medium (DMEM) were purchased from Sigma (St. Louis, MO). Z-DEVD-AFC was obtained from Calbiochem (La Jolla, CA).
Human breast cancer MCF-7 cells were cultured in DMEM supplemented with 10% heat-inactivated fetal bovine serum, 100 U/ml penicillin and 100 μg/ml streptomycin. Cells (~5–6 × 106) were plated on 60 mm culture dishes and incubated in media containing various concentrations of ginkgolide B for 24 h. The cells were then washed twice with ice-cold PBS and lysed in lysis solution (600 μL, 20 mM Tris-HCl, pH 7.4, 1 mM EDTA, 1 mM EGTA, 1% Triton X-100, 1 mM benzamidine, 1 mM phenyl-methylsulfonyl fluoride, 50 mM NaF, 20 mM sodium pyrophosphate and 1 mM sodium orthovanadate) on ice for 10 min. The cell lysates were collected, sonicated on ice for 3 × 10 sec, and then centrifuged at 15,000 × g for 20 min at 4°C. The resulting supernatants were used as the cell extracts.
The MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) test is a colorimetric assay that measures the percentage of cell survival. Following treatment of cells with ginkgolide B, 100 μl of 0.45 g/l MTT solution was added to each well in 96 wells culture plate. Cells were incubated at 37°C for 60 min to allow color development, and 100 μl of 20% SDS in DMF-H2O (1:1) solution was added to each well to halt the reaction. The plates were then incubated overnight at 37 °C to dissolve the formazan products. The results were analyzed by spectrophotometry using an ELISA reader at a wavelength of 570 nm.
Oligonucleosomal DNA fragmentation (a hallmark of apoptosis) was measured using the Cell Death Detection ELISAplus kit (Roche Molecular Biochemicals, Mannheim, Germany). Cells (1×105) were treated with or without the indicated concentrations of ginkgolide B at 37 °C for 24 h, the procedures were performed according to the manufacturer's protocol, and spectrophotometric data were obtained using an ELISA reader at 405 nm. In addition, cells were incubated with propidium iodide (1 μg/mL) and Hoechst 33342 (2 μg/mL) at room temperature for 10 min, and fluorescent microscopy was used to identify the percentage of propidium iodide-impermeable cells having condensed/fragmented nuclei (apoptotic) and the percentage of propidium iodide-permeable cells (necrotic). In each experiment, 7–10 independent fields (~600–1000 nuclei in total) were counted per condition.
ROS arbitrary units were measured using 2′-7′-dichlorofluorescein diacetate (DCF-DA) or dihydrorhodamine 123 (DHR 123) dye. Cells (1.0 × 106) were incubated in 50 μL PBS containing 20 μM DCF-DA or 20 μM DHR 123 for 1 h at 37°C, and relative ROS units were determined using a fluorescence ELISA reader (excitation 485 nm, emission 530 nm). An aliquot of the cell suspension was lysed, the protein concentration was determined, and the results were expressed as arbitrary absorbance units/mg protein.
Cells were dispensed into 96-well plates, grown for 24 h, and incubated with various concentrations of ginkgolide B for 24 h. Fluorescent dyes, DiOC6(3) (40 nM) or TMRE (1 μM), were added to each well, incubated for 15 min, and fluorescence measured with a plate spectrofluorometer [excitation: 485 nm (DiOC6(3)) or 535 nm (TMRE); emission: 535 nm (DiOC6(3)) or 590 nm (TMRE)] [
Caspase-9 activity was assayed using the Colorimetric Caspase-9 Assay Kit (Calbiochem, CA). Caspase-3 activity was measured using the Z-DEVD-AFC fluorogenic substrate, as previously described [
The [Ca2+]i was detected with Fluo-3 AM fluorescence dye, using a modification of the previously reported method [
The DAF-2DA fluorescence dye was used to detect intracellular NO, according to a modification of the previously reported method [
Total RNA was extracted with the TRIzol reagent (Life Technologies) and purified with an RNeasy Mini kit (Qiagen), according to the manufacturers' protocols. Real-time PCR was carried out with an ABI 7000 Prism Sequence Detection System (Applied Biosystems). The β-actin mRNA levels were quantified as an endogenous control, and used for normalization. The primers used for PCR were as follows: p53, 5′-CCC ATC CTC ACC ATC ATC AC-3′ and 5′-GTC AGT GGG GAA CAA GAA GTG-3′; p21, 5′-GCC GAA GTC AGT TCC TTG TGG A-3′ and 5′-GTG GGC GGA TTA GGG CTT-3′.
Lipofectamine was used to transfect MCF-7 cells with 150 nM of siRNA for targeting against p53 (5′-GACUCCAGUGGUAAUCUACTT-3′; sip53) or a scrambled control duplex (5′-GCGCGCUUUGUAGGAUUCG-3′; siScr). Twenty-four hours post-transfection, fresh culture medium was added, and the cells were treated with or without ginkgolide B for another 24 h.
Data were analyzed using one-way ANOVA, and the differences were evaluated using a Student's t-test and analysis of variance. A P-value <0.05 was considered significant.
Effects of ginkgolide B on MCF-7 cells. Cells were incubated with or without various concentrations of ginkgolide B (GB) for 24 h. (A) Cell viability was determined by MTT assay; (B) The percentages of apoptosis and necrosis were determined by propidium iodide (PI) and Hoechst 33342 staining; (C) Apoptosis was evaluated using the Cell Death Detection ELISA kit. Values are presented as means ± SD of six determinations. *P<0.05, **P<0.01 and ***P<0.001 versus the control (ginkgolide B-free) group.
Ginkgolide B induces ROS generation in MCF-7 cells. Cells were incubated with 20 μM DCF-DA or 20 μM dihydrorhodamine 123 (DHR 123) for 1 h, and treated with various concentrations of ginkgolide B (GB) for another 24 h. (A) ROS generation was assayed by DCF-DA or DHR 123 fluorescence, and expressed as absorbance/mg of protein; (B, C) Cells were pre-incubated with N-acetyl cysteine (NAC; 300 μM) or α–tocopherol (Toc; 300 μM) for 30 min and then treated with ginkgolide B (80 μM) for another 24 h. ROS generation was assayed using DCF-DA or DHR 123 dye (B). Apoptosis was evaluated using the Cell Death Detection ELISA kit (C). The data are representative of eight independent experiments. **P<0.01 and ***
Ginkgolide B triggers changes in intracellular calcium and NO content in MCF-7 cells. (A) Cells were incubated with ginkgolide B (GB) as indicated for 24 h. Intracellular Fluo-3 fluorescence intensity was measured in the presence/absence of extracellular Ca2+. (B) We examined the intracellular Ca2+ level changes triggered by treatment with ginkgolide B (GB; 80 μM), and the effects of ROS and NO inhibitors (NAC: 300 μM; L-NMMA: 400 μM; PTIO: 20 μM). (C) Cells were pretreated with L-NMMA (400 μM) or EGTA (400 μM) for 30 min and then incubated with ginkgolide B. Intracellular NO generation was measured by DAF-2DA fluorescence dye. Data are presented as percentage of control group. The data are representative of eight independent experiments. *
Loss of MMP and activation of caspase-9 and -3 by ginkgolide B of MCF-7 cells. Cells were incubated with or without various concentrations of ginkgolide B (GB) for 24 h. (A) Mitochondrial membrane potential (MMP) changes were analyzed using 40 nM DiOC6(3) or 1 μM TMRE. (B) Caspase-9 activities were assayed using the Colorimetric Caspase-9 Assay kit. (C) Caspase-3 activities were analyzed using Z-DEVD-AFC as the substrate. Values are presented as means ± SD of six determinations. *
NO involved in ginkgolide B-induced apoptotic biochemical changes in MCF-7 cells. Cells were pretreated with PTIO (20 μM) for 1 h and then treated with ginkgolide B (80 μM) for another 24 h. MMP change (A), activities of caspase-9 (B) and caspase-3 (C) were analyzed. Values are presented as means ± SD of eight determinations. ***
Effect of NAC and PTIO on the mRNA expression levels of p53 and p21. Cells were pre-incubated with or without NAC (300 μM) and PTIO (20 μM) for 1 h and then treated with ginkgolide B (80 μM) for another 24 h. The mRNA expression levels of p53 (A) and p21 (B) were analyzed using real-time PCR. The given values are representative of eight determinations. ***
Knockdown of p53 can protect MCF-7 cells against ginkgolide B-induced apoptosis. Cells were transfected with siRNA targeting p53, incubated for 24 h, and then treated with ginkgolide B (80 μM) for another 24 h. (A) The mRNA expression levels of p53 (A) and p21 (B) were analyzed using real-time PCR. (B) Cell apoptosis was measured as described in
Scheme of events occurring during ginkgolide B-induced cell apoptosis in MCF-7 cells.
This work was supported by grants (NSC95-2311-B-033-001-MY3 and NSC96-2627-M-033-002) from the National Science Council of Taiwan, ROC.


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2014 Houston: Target Ganassi IndyCar Race Preview
Posted by: newsla on Jun 25, 2014 - 06:25 AM
2014 Houston: Target Ganassi IndyCar Race Preview
Races: The Shell and Pennzoil Grand Prix of Houston Race 1, June 28
The Shell and Pennzoil Grand Prix of Houston Race 2, June 29
Drivers: @scottdixon9 @tonykanaan
Cars: No. 9 and No. 10 Target Chevrolets
Track: Reliant Park (1.7-street course) in Houston, Texas
TV: Race 1: NBC Sports Network 3:00pm ET
Race 2: NBC Sports Network 3:00pm ET
Social: @CGRTeams #TeamTarget
BET YOU DIDNâT KNOW THAT
Houston, We Donât Have a Problem: Target Chip Ganassi Racing (TCGR) has won on the Streets of Houston twice (2000, 2013), claimed six podiums (1998, twice-2000, 2001, twice-2013) and finished inside the top-five seven times (twice-1998, twice-2000, 2001, twice-2013).
Launch Sequence Engaged: TCGR has topped the speed charts in four out of the first eight races of the 2014 Verizon IndyCar Series. Scott Dixon set the fastest laps of the Honda Indy Grand Prix of Alabama, the Inaugural Grand Prix of Indianapolis and the second race of the Chevy Indy Dual in Detroit, while Tony Kanaan set the fastest lap of the Firestone 600 on June 7.
Month to Month: After spending most of May in Indiana for the inaugural Grand Prix of Indianapolis and the 98th running of the Indianapolis 500 , TCGR is spending much of June in Texas. The team was in Fort Worth on June 7 for the Firestone 600 and now is preparing for the double-header Grand Prix on the Streets of Houston this weekend.
Reliable Racing: Up to this point in the 2014 Verizon IndyCar Series season, TCGR has completed 1777 out of a possible 1858 laps, or 96 percent.
100+ Wins and Countingâ¦: The Target Racing Program, which began with Target and Chip Ganassi Racing in 1990, will be contending for their 105th win as the season progresses. The first win for the program came in 1994 with Michaelâs Andrettiâs Indy car victory at Surfers Paradise, Australia, when the team was a two-car, Indy car program. 103 wins later, the programâs umbrella not only includes involvement in the Verizon IndyCar Series, but in the NASCAR Sprint Cup Series and the TUDOR United SportsCar Championship. The partnership between Target and Chip Ganassi Racing is one of the longest consecutive team partnerships in motor racing history.
Finding New Roads: All four CGRT Indy cars are utilizing the Chevrolet 2.2-liter twin turbocharged V6 engine for 2014 season. The engine produces well over 600 horsepower and close to 300 lb. ft. of torque.
Racing Royalty: Former TCGR driver Dario Franchitti was among sports figures to be honored in Queen Elizabeth IIâs birthday list earlier this month. The four-time Verizon IndyCar Series champion and three-time Indianapolis 500 winner from Scotland was made a Member of the Order of the British Empire for services to motor racing. Earlier this year, Franchitti also received the honor of being named the pace car driver for the 98th running of the Indianapolis 500, where he led the field around during the opening laps in a 2014 Chevrolet Camaro Z/28. After retiring from his racing career at the end of 2013, Franchitti returned to Team Target in 2014 as a driving advisor for CGRT. Franchitti assists the team as it adapts to recent lineup changes and additions, and was on site with the team for the Chevrolet Indy Dual in Detroit at Belle Isle at the end of May as well as the Firestone 600 on June 7. He will continue to work closely with the teamsâ Verizon IndyCar Series drivers throughout the duration of the season.
Follow the Leader: On May 22, Chip Ganassi was inducted into the Auto Racing Hall of Fame alongside Jimmy McElreath, Leo Mehl, Bobby Rahal and Bill Simpson. There are now 148 members in the elite fraternity, which is located at the Indianapolis Motor Speedway Hall of Fame Museum.
Follow Team Target on Twitter: Continue to follow Target Chip Ganassi Racing through Chip Ganassi Racingâs official team Twitter page. Find in-race updates and weekly news on the No.9 and No.10 Target teams throughout the 2014 season by following ���â@CGRTeamsâ.
Scott Dixon and No. 9 Target Team
Eyes on the Prize: In three starts on the Streets of Houston, Scott Dixon has finished on the podium twice. At the end of the 2013 Verizon IndyCar Season, he claimed a victory and a second-place finish in the Houston double-header on his way to clinching the Series Championship.
Fast Father: Dixon enjoyed Fatherâs Day by spending time with his daughters in Indianapolis, Ind. during the day and then at night ventured to Kokomo, Ind. with his crew chief Blair Julian to watch a USAC Honda National Midget Series race at Kokomo Speedway where fellow Indiana resident and former Indy car driver Bryan Clauson claimed the victory.
The Best Defense Is A Good Offense: Dixon will spend the 2014 season attempting his first successful defense of a Verizon IndyCar Series title. "I think it's obviously a good problem to have," Dixon said. "I've been in this situation a couple of times before⦠I think we need to focus on making a good start in the first three or four races." His closest effort so far came in 2009 when he finished second to teammate Dario Franchitti by a mere 11 points. If Dixon is successful, he will become the 14th driver to have at least two consecutive series championships.
Go with What you Know: 2014 marks Dixonâs 13th year with Team Target â the longest tenure for a driver in team history (1990-Present).
The Ice Man Returns: The three-time Verizon IndyCar Series Champion (2003, 2008, 2013) and 2008 Indianapolis 500 Winner returns in 2014 for his first season alongside 2004 Series Champion and 2013 Indianapolis 500 Winner Kanaan. Dixon, the active wins leader, is in seventh place on the all-time list (1909-Present) with 33 victories, ranking only behind A.J. Foyt, the Andrettiâs (Mario and Michael) and Unserâs (Al, Bobby and Al Jr.). His next pole (21st) will see him tied for 13th on the all-time list with Gil De Ferran.
Title Talk: Should reigning Verizon IndyCar Series Champion Dixon take home the 2014 Verizon IndyCar Series title, he would become the fifth driver to win four Indy car titles (AJ Foyt, Mario Andretti, Sebastien Bourdais, Dario Franchitti). Dixon won the title in 2003, 2008 and again in 2013.
Moving Forward: With his next victory, Dixon would tie Al Unser Jr. for sixth on the all-time wins list. Dixon won his 33rd race at Houston's Reliant Park in October 2013. A victory in 2014 will extend Dixonâs streak of consecutive seasons with a win to 10; while qualifying in the top spot would mark eight consecutive seasons with a pole. He has led at least one race for 12 consecutive seasons. Dixon has 164 consecutive starts, placing him in sixth on the all-time list and in second place behind teammate Kanaan for active drivers.
Tony Kanaan and No. 10 Target Team
Top Shelf Racing: In five starts on the Streets of Houston, Tony Kanaan has finished inside the top-10 on three occasions (1998, 1999, 2000).
Peculiar Pairing: The pairing of Dixon and Kanaan marks the first time the reigning Indianapolis 500 Winner and the reigning Verizon IndyCar Series Champion will be teammates since 2002, when Team Penske had 2001 Indianapolis 500 Winner Helio Castroneves and 2001 CART Champion Gil de Ferran. The pairing of the two titleholders has only happened five times in Indy car history (1972 â Al Unser, 1971 Indianapolis 500 Winner and Joe Leonard, 1971 USAC Champion for Velâs Parnelli Racing; 1986 â Danny Sullivan, 1985 Indianapolis 500 Winner and Al Unser, 1985 CART Champion for Team Penske; and in 1989 â Rick Mears, 1988 Indianapolis 500 Winner and Danny Sullivan, 1988 CART Champion for Team Penske.
TK Joins The Team: 2004 Verizon IndyCar Series Champion and 2013 Indianapolis 500 Winner Kanaan joins TCGR in 2014 for his first season alongside three-time Champion and 2008 Indianapolis 500 Winner Dixon. Kanaan has 16 career wins and 15 poles entering the 2014 season, and will seek to add to his record for consecutive Indy car starts, which is at 222. Only four other active drivers (Dixon, Helio Castroneves, Marco Andretti, Ryan Hunter-Reay) possess a streak of more than 100 consecutive starts. Competing in every race will push his career starts total to 295 â which would be good enough for ninth on the all-time list. Kanaan has 113 career top-five finishes. He is ranked fifth for the number of victories among active full-time drivers in the Verizon IndyCar Series.
PaddockTalk Perspective
Also in IndyCar Weekend Team Reports:
2014 Houston: Charlie Kimball IndyCar Race Preview
2014 Houston: Ryan Briscoe IndyCar Race Preview
2014 Texas: Andretti Autosport IndyCar Race Recap
2014 Texas: Rahal Letterman Lanigan IndyCar Race Recap
2014 Texas: Andretti Autosport IndyCar Qualifying Recap
2014 Texas: Rahal Letterman Lanigan IndyCar Qualifying Recap
2014 Texas: Chevrolet IndyCar Qualifying Recap
2014 Texas: Ganassi IndyCar Race Preview
2014 Texas: Charlie Kimball IndyCar Race Preview
2014 Texas: Ryan Briscoe IndyCar Race Preview
2014 Texas: Chevrolet IndyCar Race Preview
2014 Texas: Jack Hawksworth IndyCar Race Preview
2014 Texas: Rahal Letterman Lanigan IndyCar Race Preview
2014 Texas: KVSH Racing & KV AFS Racing IndyCar Race Preview
2014 Detroit: Andretti Autosport IndyCar Race Two Recap
2014 Detroit: Rahal Letterman Lanigan IndyCar Race Two Recap
2014 Detroit: Chevrolet IndyCar Race Two Recap
2014 Detroit: Chevrolet IndyCar Race One Recap
2014 Detroit: Rahal Letterman Lanigan IndyCar Race One Recap
2014 Detroit: Andretti Autosport IndyCar Race One Recap
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Stop-Loss: A Look at the US Military Policy that Creates a "Backdoor Draft" to Force Soldiers to Continue Service
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Teachers claim that more and more parents are shouting at referees and encouraging their children to cheat.
One primary school in north London has a list of eight rules for parents to follow.
No swearing
One rule is that parents are not allowed to swear, and another one reminds them that the referee's decision is always final.
One said: "You get these dads shouting things like 'get the man, not the ball'. It's probably quite scary if you are a little boy of 11 and have all these dads swearing."


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Have a Tax Question? Ask a Tax Expert
hello, my name is XXXXX XXXXX i'm the tax-doctor.
yes, you'd need to file 1040 sch E and treat monthly payments as rental income in order to write-off interest, property taxes, repairs etc...
thank you, XXXXX XXXXX you require further assistance with this question please ask and i'll follow-up.
once fully satisfied with my answer please rate it so that i'm pd for my answer.
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Obama and the New Yorker's satirical cover. Have you heard about this?
this will be on the cover of the the July 21st issue of the New Yorker,
It shows Michelle with an Afro and an AK 47 and Barack doing the fist bump with Barack in a turban
I just saw this today on the morning news. The only thing I heard was that both Obama and McCain campaign spokesmen have denounced it.
I have not read the article that goes with it so I am unsure as to how the picture relates to it.
I'd have to read the artice to gauge it for myslef.
But, I can see how those who already feel that way anyway (thoes types who go the Obama/Osama route or still think that Obama is a Muslim) would jump all over it.
i like it very much but i wish it wasn't on the cover. there are many people who won't read the article or understand it as satire as they're walking quickly by newstands. i can imagine that picture being a catalyst for imprinting negative views about the obamas.
*I* think it's funny, because it's so obviously sarcasm and I'm a big, big fan of sarcasm, but a lot of people won't get it or will interpret it to mean something sinister. Which is a shame, because if you take it for what it's presumably intended, it's farking hilarious.
Great I had just convinced my dad that the email circulating around was false, this will not help my effort!
it's been a long time since i've purchased the new yorker. i'll have to pick up that issue. i like that side eye action that barack is giving.
what's up with michelle's afro? does afro=angry militant. i wear an afro sometimes. :sad10:
Yeah, I don't see anything good coming of that. Stupid New Yorker.
And yeah, the side eye action from Barack is pretty much what makes it for me. High Larious.
I agree with Frau and Utopiastars.
Definitely read the article. Very insightful.
My initial reaction was "that's wrong and inappropriate" Then I looked at his other work. He just likes to show the absurdities of opinions. I can dig that. GB the (almost) free press.
I have no problem with it. The New Yorker covers are genius and this is no exception. I can't wait to read the story.
Also, this is classic Barry Blitt. His work is often hilariously shocking.
As for the repercussions of people walking by seeing it, The New Yorker has, for many years now, had a 1/2 vertical page with story titles and page numbers on it. It heavily obscures the cover illustration. This is done to boost newsstand sales, since they've never printed words on their cover other than the title of the mag, choosing instead to feature a full page illustration.
So, in other words, unless someone picks up the mag to look at it, they're not going to see much of the illo, just the upper right corner [assuming the newsstand itself will obscure the bottom portion].
i have really mixed feelings about this. i'm a big fan of the first ammendment--it keeps me employed!--and i can appreciate good satire.
but having said that, looking at this, my immediate reaction wasn't, "wow, that's some good satire." i found it inappropriate & offensive.
also, the new yorker is usually a little more nuanced in its satire.
David's interview on huffingtonpost.com.
My favorite question and answer:
Q: A number of commenters also wondered if there was a cover in the offing that would depict McCain unflatteringly - do you have any policy or general customs regarding the even treatment of candidates in terms of coverage, and covers? A: Oh, we get around to everybody I hope.
I have mixed feelings about it. My first reaction was to cringe, but later I thought it was pretty funny. As for whether they should have run it, I am undecided. I agree that it might have been more effective inside the magazine rather than the cover.
Part of my dissertation actually dealt with a really popular satirical poem that was completely misunderstood by most readers and that misunderstanding had dramatic political consequences. The poet's intention was to satirize racism, but the poem ended up being used straightforwardly, as support for racism. That's what this image reminds me of. It risks supporting the attitudes and opinions it's attempting to satirize. As journotraveler said, the New Yorker is usually more nuanced in its satire, but I think that the problem here is that, as ridiculous and over-the-top as the image seems, it's not at all far off from what a lot of people are thinking. It wouldn't be an exaggeration to those people; it would be a portrait!
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The 7 Piece Custom Spa Kit Tote is the perfect gift to show your appreciation and promote a stress free environment.
A total comfort custom spa kit will make a perfect gift to show your appreciation of a job well done.
These promotional products from ePromos are ready to ship in 24 hours. Rush promotional items for a last minute event or if you're other supplier fell through.


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Improving the Global Economic Environment by Empowering Women
Women in developing economies are, historically and traditionally, the breadwinners for their families. Improving the global economy, specifically in African society, requires that women be empowered, financially, socially and intellectually. However, this empowerment generally is diminished given the limitations placed on them by men. Micro financing is intended to alleviate poverty by providing small loans to help women develop small businesses. Micro financing programs have, undoubtedly, helped to lift millions out of poverty. Perhaps greater emphasis might be placed on wealth development, and less on poverty alleviation. This article will identify and discuss factors essential to building wealth in African economies. It will attempt to define empowerment and to answer the question, is microfinance a viable approach in developing countries and in the U.S.?
Keywords: Micro Finance, Wealth Creation, Poverty Alleviation, Empowering Women
Dr. Ann-Lorraine Edwards
Visiting Assistant Professor of Management, Department of Management & Marketing
Ref: D08P0473


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Thursday, September 30, 2010
2010 Harvest. What's that all about?
The "Merus" block has been saved from this predicament by Larry's quick action with the water valves. Sadly, Midorya Hills fell victim to the heat spikes this year. The good news is the damage to Midoriya seems to only be an issue with the quantity, not the quality of the fruit. For some unknown reason the fruit that was exposed to the sun just decided to die off. Hopefully what is left will have twice the flavor. We will see. The Berry Lane Chardonnay also shows the raisining effect with most of the fruit in good shape but some of the exposed berries turned scary black.
Our handy de-stemmer machine takes the grapes off the stems and leaves the raisins behind. So, other than the lack of fruit we should be in excellent position for an amazing year when it comes to quality.
Posted by Ted Henry at 10:49 PM
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Mountain Moral Monday 2, is a little over 2 weeks away, and I need your help!
Plans are in motion for 880 to outdo ourselves this year, for the second Mountain Moral Monday coverage, and I would like to solicit some help from the listener base:
As we did last year, we will be broadcasting our whole show live from Pack Square Park. From 3 PM to 5 PM, I would like to talk to people live as they arrive (since we can't do phone calls) and I want to line up some great interviews.
Last year, I had Leni Sitnick, Patsy Keever, Barry Summers, and a few others on the show.
I would love to hear some suggestions from you guys, as to who I should try and book for interviews.
Post your suggestions below!


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View of the concrete lower culvert that passes underneath Sea View
Street. This lower pipe was installed at an invert below the adjacent creek
bottoms and has partly filled in with sediment and debris.
Image ID: r0011808, NOAA's Restoration Center Collection
Location: Massachusetts,Brewster/Dennis, Barnstable County
Photo Date: Mid - February, 2001
Credit: NOAA Restoration Center, Louise Kane
• High Resolution Photo Available
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I would like en bloc; i have mentor saline implants (in 1994) by dr.ralston. i have experienced illnesses sent inplant in 1994; have been diagnosed sle and ms, chronic headaches, now joint, neck and ar m pain, shoulder pain, fatiue, fibromyalgia, hair loss, hormonal problems, lack of energy, i am sick all the time for one thing or another. i have had these same implants for 20 years.
49 5 kids, experiencing a flood of illnesses - Ogden, UT
I would like en bloc; i have mentor saline implants...
ba was great,no complaints other than one side, the nipple sits lower.but i have had may health issues and just want them removed and possibly lifted. i cannot deal with the ongoing medical problems i have been experiencing for 20 years.
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TNA will be taping more of the One Night Only pay-per-views at Universal Studios in Orlando on March 17th, 23rd & 24th.
Two pay-per-views are being taped each day. The first one starts at 1 PM & the second at 7 PM.
I wonder if the arena is literally empty will they cancel one.. or two….. or three…. being tape so ar in advance I couldnt see them being more than bracket type shows to determine a number one contender….
They already have 2 that havent aired yet. I guess the "cutting down on PPVs" means cutting down on LIVE ppvs.
That far in advance will confuse story lines, but if they think in advance, I guess it could work
unless a major injury occurs. doing stuff like this you then have to deal with the great unknown events that happen to talent in the future , which could reuin storylines from these shows.
Good point, I didnt think of that… I know the future of a potential aces and 8s member because of 1 night only.
People hate spoilers so i will be silent 🙂


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THE CHAIRMAN, RAILWAY BOARD & ORS. Vs. MRS. CHANDRIMA DAS & ORS.
Head Notes
Dismissing the appeal, this Court HELD : 1. Where public functionaries are involved and the matter relates to violation of Fundamental Rights or the enforcement of public duties, the remedy would still be available under the Public Law not-withstanding that a suit could be filed for damages under Private Law. In the instant case, it is not a mere matter of violation of an ordinary right of a person but violation of Fundamental Rights which is involved. Public Law remedies have also been extended to the realm of tort and compensa-tion awarded to victims for having suffered personal injuries at the hands of the officers of the Government. [493-A-B; 492-A-B] Bodhisatwa v. Ms. Subdhra Chakroborty, [1996] 1 SCC 490; Common Cause, A Regd. Society v. Union of India & Ors., [1999] 6 SCC 667 = AIR (1999) SC 2979 = (1999) 5 JT 237, relied upon. Life Insurance Corporation of India v. Escorts Limited & Ors., [1985] Supp. 3 SCR 909 = [1985] 1 SCC 264 = AIR (1986) SC 1370; Rudul Sah v. State of Bihar, [1983] 3 SCR 508 = [1983] 4 SCC 141 = AIR (1983) SC 1086, referred to. Bhim Singh v. State of Jammu & Kashmir, [1985] 4 SCC 577 = AIR (1986) SC 494; People's Union for Democratic Rights v. State of Bihar, [1987] 1 SCR 631 = [1987] 1 SCC 265 = AIR (1987) SC 355; People's Union for Democratic Rights Thru. Its Secy. v. Police Commissioner, Delhi Police Headquarters, [1989] 4 SCC 730 = [1989] 1 SCALE 599; SAHELI, A Woman's Resources Centre v. Commissioner of Police, Delhi, [1990] 1 SCC 422 = [1989] Supp. SCR 488 = AIR (1990) SC 513; Arvinder Singh Bagga v. State of U.P., [1994] 6 SCC 565 = AIR (1995) SC 117; P. Rathinam v. Union of India, [1989] Supp. 2 SCC 716; In Re : Death of Sawinder Singh Grower, [1995] Supp. 4 SCC 450 = JT (1992) 6 SC 271 = [1992] 3 SCALE 34; Inder Singh v. State of Punjab, [1995] 3 SCC 702 = AIR (1995) SC 1949; D.K. Basu v. State of West Bengal, [1997] 1 SCC 416 = AIR (1997) SC 610; Nilabati Behera v. State of Orissa, [1993] 2 SCC 746 = [1993] 2 SCR 581 = AIR (1993) SC 1960; State of M.P. v. Shyam Sunder Trivedi, [1995] 4 SCC 262 = [1995] 3 SCALE 343; People's Union for Civil Liberties v. Union of India, [1997] 3 SCC 433 = AIR (1997) SC 1203; Kaushalya v. State of Punjab, [1996] 7 SCALE (SP) 13; Supreme Court Legal Aid Com-mittee v. State of Bihar, [1991] 3 SCC 482; Dr. Jacob George v. State of Kerala, [1994] 3 SCC 430 = [1994] 2 SCALE 563; Paschim Bangal Khet Mazdoor Samity v. State of West Bengal & Ors., [1996] 4 SCC 37 = AIR (1996) SC 2426 and Mrs. Manju Bhatia v. N.D.M.C., [1997] 6 SCC 370 = AIR (1998) SC 223 = [1997] 4 SCALE 350, cited. 2.1. The argument that the victim was a foreign national and, therefore, no relief under Public Law could be granted to her as there was no violation of the Fundamental Rights available under the Constitution must also fail for two reasons; first, on the ground of Domestic Jurisprudence based on Con-stitutional provisions and secondly, on the ground of Human Rights Jurisprudence based on the Universal Declaration of Human Rights, 1948, which has the international recognition as the "Moral Code of Conduct' having been adopted by the General Assembly of the United Nations. The Internation-al Covenants and Declarations as adopted by the United Nations have to be respected by all signatory States. The applicability of the Universal Declara-tion of Human rights and principles thereof may have to be read, if need be, into the domestic jurisprudence. [495-E-G; 498-D-E] Salomon v. Commissioner of Customs and Excise, (1996) 3 All ER 871; Brind v. Secretary of State for the Home Department, (1991) 1 All ER 720, referred to. 2.2. The victim who was not a citizen of this country but came here as a citizen of Bangladesh was, nevertheless, entitled to all the constitutional rights available to a citizen so f ar as "Right to Life" was concerned. She was entitled to be treated with dignity and was also entitled to the protec-tion of her person as guaranteed under Article 21 of the Constitution. As a national of another country, she could not be subjected to a treatment which was below dignity nor could she be subjected to physical violence at the hands of Government employees who in fact outraged her modesty. The Right available to her under Article 21 was thus violated. Consequently, the State is liable to pay compensation to her. [502-C-D] 2.3. Our Constitution guarantees all the basic and fundamental human rights set out in the Universal Declaration of Human Rights, 1948, to its citizens and other persons. The chapter dealing with the Fundamental Rights is contained in Part III of the Constitution. The purpose of this Part is to safeguard the basic human rights from the vicissitudes of political controversy and to place them beyond the reach of the political parties who, by virtue of their majority, may come to form the Government at the Centre or in the State. Fundamental Rights are available to all "citizens" of the country but a few of them are also available to "persons". While Article 14, which guarantees equality before law or the equal protection of laws within the territory of India, is applicable to "person" which would also include "citizen" of the country and "non-citizen" both, Articles 15, 16 and 19 speak only of "citizen". The word "citizen" in Article 19 has not been used in a sense different from that in which it has been used in Part II of the Constitution dealing with "citizenship". [499-C-E; 500-B] State Trading Corporation of India Ltd. v. The Commercial Tax Officer and Others, AIR (1963) SC 1811 = [1964] 4 SCR 99; Hans Muller of Nurenburg v. Superintendent, Presidency Jail Calcutta, AIR (1955) SC 367 (374) = [1955] 1 SCR 1284; Anwar v. State of J & K, AIR (1971) SC 337 = [19711 SCR 637 = [1971] 3 SCC 104; Naziranbai v. State, AIR (1957) M.B. 1; Lakshmi Prasad & Anr. v. Shiv Pal & Others, AIR (1974) Allahabad 313; Sk. Md. Soleman v. State of West Bengal and Another, AIR (1965) Calcutta 312, referred to. 2.4. The word "LIFE" has also been used prominently in the Universal Declaration of Human Rights, 1948. The Fundamental Rights under the Constitution are almost in consonance with the Rights contained in the Universal Declaration of Human Rights as also the Declaration and the Covenants of Civil and Political Rights and the Covenants of Economic, Social and Cultural Rights, to which India is a party having ratified them. That being so, since "LIFE" is also recognised as a basic human right in the Universal Declaration of Human Rights, 1948, it has to have the same meaning and interpretation as has been placed on that word by this Court in its various decisions relating to Article 21 of the Constitution. The meaning of the word "life" cannot be narrowed down. According to the tenor of the language used in Article 21, it will be available not only to every citizen of this country, but also to a "person" who may not be a citizen of the country. Article 20 guarantees right to protection in respect of convic-tion for offences. Article 21 guarantees right to life and personal liberty while Article 22 guarantees right to protection against arbitrary arrest and detention. These are wholly in consonance with Articles 3, 7 and 9 of the Universal Declaration of Human Rights, 1948. [500-F-H; 501-A-B] Anwar v. State of J & K, AIR (1971) SC 337 = [1971] 1 SCR 637 = [1971] 3 SCC 104; Kubic Darusz v. Union of India & Ors., [1990] 1 SCC 568 = AIR (1990) SC 605; Kharak Singh v. State of U.P., AIR (1963) SC 1295 = [1964] 1 SCR 332; Bandhua Mukti Morcha v. U.O.I., AIR (1984) SC 802 = [1984] 2 SCR 67 = [1984] 3 SCC 161, referred to. State of Maharashtra v. Chandrabhan Tale, AIR (1983) SC 803 = [1983] 3 SCR 337 = [1983] 3 SCC 387; Maneka Gandhi v. U.O.I., AIR (1978) SC 597 = [1978] 2 SCR 621 = [1978] 1 SCC 248; Board of Trustees of the Port of Bombay v. Dilip Kumar Raghavendranath Nadkami, AIR (1983) SC 109 = [1983] 1 SCR 828 = [1983] 1 SCC 124, cited. 2.5. Even those who are not citizens of this country and come here merely as tourists or in any other capacity will be entitled to the protection of their lives in accordance with the Constitutional provisions. They also have a right to "Life" in this country. Thus, they also have the right to live, so long as they are here, with human dignity. Just as the State is under an obligation to protect the life of every citizen in this country, so also the State is under an obligation to protect the life of the persons who are not citizens. [501-E-F] 3.1. The contention that the liability under the Law of Torts would arise only when the act complained of was performed in the course of official duty and since rape cannot be said to be an official act, the Central Government would not be liable even under the Law of Torts, is, wholly bad and is contrary to the settled legal position. [502-E-F] 3.2. Running of Railways is a commercial activity. Establishing Yatri Niwas at various Railway Stations to provide lodging and boarding facilities to passengers on payment of charges is part of the commercial activity of the Union of India and this activity cannot be equated with the exercise of Sovereign power. The employees of the Union of India who are deputed to run the Railways and to manage the establishment, including the Railway Stations and Yatri Niwas, are essential components of the Govt. machinery which carries on the commercial activity. If any of such employees commits an act of tort, the Union Govt., of which they are the employees, can, subject to other legal requirements being satisfied, be held vicariously liable in damages to the person wronged by those employees. [503-F-G] Kasturi Lal Ralia Ram Jain v. State of U.P., AIR (1965) SC 1039 = [1965] 1 SCR 375, held inapplicable. Common Cause, A Regd. Society v. Union of India, [1999] 6 SCC 667, referred to. State of Rajasthan v. Mst. Vidhyawati, AIR (1962) SC 933; State of Gujarat v. Memon Mahomed Haji Hasan, AIR (1967) SC 1885; Smt. Basava Kom Dyamogouda Patil v. State of Mysore, AIR (1977) SC 1749; N. Nagendra Rao & Co. v. State of A.P., AIR (1994) SC 2663 = [1994] 6 SCC 205; State of Maharashtra v. Kanchanmala Vijaysing Shirke, (1995) ACJ 1021 SC = [1995] 5 SCC 659 = JT (1995) 6 SC 155, cited. 4.1. It cannot be doubted that this petition was filed in public interest which could legally be filed by the respondent and it cannot be said that she could not file the petition as there was nothing personal to her involved in that petition. The petition filed before the High Court was not only a petition for damages or compensation for the victim. But many other reliefs, for example, relief for eradicating anti-social and criminal activities of various kinds at Howrah Railway Station were also claimed. The true nature of the petition, therefore, was that of a petition filed in public interest. [495-D; 493-G-H] 4.2. The existence of a legal right, no doubt, is the foundation for a petition under Article 226 and a bare interest, may be a of a minimum nature, may give locus standi to a person to file a Writ Petition, but the concept of "Locus Standi" has undergone a sea change in the context of Public Interest Litigation. [494-A-B] Dr. Satyanarayana Sinha v. S. Lal & Co. Pvt. Ltd., AIR (1973) SC 2720 = [1973] 2 SCC 696; S.P. Gupta & Ors. v. Union of India & Ors., AIR (1982) SC 149 = [1981] Supp. SCC 87; People's Union for Democratic Rights and Ors. v. Union of India & Ors., AIR (1982) SC 1473 = [1982] 3 SCC 235; Bangalore Medical Trust v.B.S. Muddappa and Ors., AIR (1991) SC 1902 = [1991] 3 SCR 102 = [1991] 4 SCC 54, referred to. Bandhua Mukti Morcha v. Union of India & Ors., AIR (1984) SC 802 = [1984] 2 SCR 67 = [1984] 3 SCC 161; State of Himachal Pradesh v. Student's Parent Medical College, Shimla & Ors., AIR (1985) SC 910 = [1985] 3 SCC 169, cited. CIVIL APPELLATE JURISDICTION : Civil Appeal No. 639 of 2000.
Constitution of India, 1950-Articles 32, 226-Public Law Remedies- Availability of-Claim of compensation in a writ petition under Article 226 from the Railways for the offence of rape committed by its employees on the victim, a Bangladeshi national-Maintainability of-Held, Public Law Remedies have also been extended to the realm of tort and would be available notwithstanding that a suit could be filed for damages under Private Law, where public functionaries are involved and the matter relates to the violation of Fundamental Rights or the enforcement of public duties-Grant of compensation of Rs. 10 lacs to the victim by the High Court, upheld. Public Law-Relief under, to a foreign national-Grant of-Held, the victim was entitled to all the constitutional rights available to a citizen so far as `Right to life' was concerned as the Constitution guarantees all the basic and fundamental human rights set out in the Universal Declaration of Human Rights to its citizens and other persons-Right to life includes right to live with human dignity and rape violates this right of a woman-State under a Constitutional liability to pay compensation to the rape victim as the right available to her under Article 21 was violated-Constitution of India, 1950-Articles 14, 15, 16, 19, 20, 21, 22-Universal Declaration of Human Rights 1948-Articles 3,7,9. Law of Torts-Vicarious liability-Existence of-Held, employees of the Union of India deputed to run the Railways and to manage the establishment, including the Railway Stations and Yatri Niwas, are essential components of the Govt. machinery carrying on commercial activity and for any act of tort committed by such employees, the Union Govt. would be vicariously liable in damages to the person wronged by those employees-Functions of the Govt. in a Welfare State are manifold, all of which cannot be said to be the activities relating to exercise of Sovereign powers-Contention that liability under the law of torts would arise only when the act complained of was performed in the course of official duty, held to be wholly bad- Govt. held to be vicariously liable for the offence of rape committed at the building belong-ing to the Railways and perpetrated by Railway employees. Public Interest Litigation-Locus Standi-Concept of-Petition filed in public interest by the respondent, a practising Advocate of High Court, for various reliefs including the relief for compensation for the victim of rape-Held, could legally be filed by the respondent, though the respondent was not in any way connected or related to the victim. One H, a Bangladeshi national, was gang raped by many including employees of the Railways in a room at Yatri Niwas at Howrah Station of the Eastern Railway and thereafter at a rented flat. Subsequently she was rescued by the Police following information by the landlord of the building who heard the hue and cry raised by H. Respondent No. 1, a practising Advocate of the High Court field a petition under Article 226 of the Constitution for compensation to H and several other reliefs including a direction to the appellants to eradicate anti- social and criminal activities at Howrah Railway Station. High Court awarded a sum of Rs. 10 lacs as compensation to H holding that rape was committed at the building belonging to the Railways and was perpetrated by the Railway employees. Hence this appeal by Railways. On behalf of the appellants, it was contended that the Railways would not be liable to pay compensation to the victim who was a foreigner and was not an Indian national; that the commission of the offence by persons including Railway employees would not make the Railway or the Union of India vicariously liable to pay compensation to the victim; that since it was an individual act of some persons, they alone should be prosecuted and on being found guilty should be punished; that for claim-ing damages for the offence perpetrated on the victim the remedy lay in the domain of Private Law and not under Public Law and, therefore, no compensation could have been legally awarded by the High Court in a proceeding under Article 226 of the Constitution; that the respondent was only a practising Advocate and was in no way, connected or related to the victim and therefore, she could not have filed a petition under Article 226 for damages or compensation to the victim on account of the rape com-mitted on her; that the victim was a foreign national and therefore, no relief under Public Law could be granted to her as there was no violation of the Fundamental Rights available under the Constitution; and that the Fundamental Rights in Part III of the Constitution were available only to citizens and the victim being a Bangladeshi national could not complain of the violation of Fundamental rights.
PETITIONER: THE CHAIRMAN, RAILWAY BOARD & ORS. Vs. RESPONDENT: MRS. CHANDRIMA DAS & ORS. DATE OF JUDGMENT: 28/01/2000 BENCH: R.P.Sethi, S.Saghir Ahmad JUDGMENT: S.SAGHIR AHMAD, J. Leave granted. Mrs. Chandrima Das, a practising advocate of the Calcutta High Court, filed a petition under Article 226 of the Constitution against the Chairman, Railway Board; General Manager, Eastern Railway; Divisional Railway Manager, Howrah Division; Chief Commercial Manager, Eastern Railway; State of West Bengal through the Chief Secretary; Home Secretary, Government of West Bengal; Superintendent of Police (Railways), Howrah; Superintendent of Police, Howrah; Director General of Police, West Bengal and many other Officers including the Deputy High Commissioner, Republic of Bangladesh; claiming compensation for the victim, Smt. Hanuffa Khatoon, a Bangladeshi national who was gang-raped by many including employees of the Railways in a room at Yatri Niwas at Howrah Station of the Eastern Railway regarding which G.R.P.S. Case No. 19/98 was registered on 27th February, 1998. Mrs. Chandrima Das also claimed several other reliefs including a direction to the respondents to eradicate anti-social and criminal activities at Howrah Railway Station. The facts as noticed by the High Court in the impugned judgment are as follows:- "Respondents Railways and the Union of India have admitted that amongst the main accused you are employees of the railways and if the prosecution version is proved in accordance with law, they are perpetrators of the heinous crime of gang rape repeatedly committed upon the hapless victim Hanufa Khatun. It is not in dispute that Hanufa came from Bangladesh. She at the relevant time was the elected representative. She at the relevant time was the elected representative of the Union Board. She arrived at Howrah Railway Station on 26th February, 1998 at about 14.00 hours to avail Jodhpur Express at 23.00 Hours for paying a visit to Ajmer Sharif. With that intent in mind, she arrived at Calcutta on 24th February, 1998 and stayed at a hotel at 10, Sudder Street, Police Station Taltola and came to Howrah Station on the date and time aforementioned. She had, however, a wait listed ticket and so she approached a Train Ticket Examiner at the Station for confirmation of berth against her ticket. The Train Ticket Examiner asked her to wait in the Ladies Waiting room. She accordingly came to the ladies waiting room and rested there.


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A video record of the Let There Be Daylight event in New York on January 15, 2013. EETD's Stephen Selkowitz was one of the speakers, addressing the post-occupancy study of the shading and daylighting system deployed in 2007 at The New York Times building.
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|From: Noel Welsh (noelwelsh at gmail.com)
Date: Mon Jan 17 10:01:12 EST 2011
Well, that didn't work, but we've decided to upgrade to Racket anyway :) What's the equivalent process for Racket? Thanks, N. On Wed, Jan 12, 2011 at 12:58 PM, Matthew Flatt <mflatt at cs.utah.edu> wrote: > At Wed, 12 Jan 2011 11:29:03 +0000, Noel Welsh wrote: >> I'm trying to build 4.2.2 without building the docs. I thought I could >> just run make and then setup-plt -D, but make does not install the >> binaries. Looking through the Makefile did not lead to enlightenment. >> Any suggestions? > > Does `make plain-install' followed by `setup-plt -D' work? (Version > 4.2.2 is old enough that I forget what worked back then.) > >
|Posted on the dev mailing list.


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I look at my life and realize how incredible it is to find myself at the GTU in Berkeley. I am an American citizen, born and raised in Omaha, Nebraska, but my abuelita (grandmother) is quick to remind me, "Mexican comes before American. You are Mexican-American and do not forget it."
A stack of colorful cuadros — Spanish for "pictures" — sits on Rebecca Berru Davis' sofa. They are hand-appliquéd and embroidered textile scenes created by a cooperative of women artists in Pamplona Alta, a shantytown outside Lima, Peru. Davis, a third-year Graduate Theological Union doctoral student in the area of Art and Religion, has just returned from her third trip to Pamplona Alta since 2006.
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text:
The Hyundai Boys and Girls Choir was founded in 1990 in Ulsan, South Korea, to promote the development of local culture and make the hopes and dreams of children come true.
The choir has performed with the Vienna Boys' Choir, the Little Singers of Paris and The Choirs of Aachen in Germany, and has appeared at the National Boys and Girls Choral Festival, the South Korea Choral Festival, and the World Choir Olympics, as well as in numerous exchange concerts and guest performances.
The choir's repertoire includes songs from numerous genres including folk music, hymnal pieces, secular music, and show tunes from musicals.


text:
Midwives and nursing staff at Blacktown Hospital were right to attempt to send home a woman who went on to give birth alone in a ward, a leading Australian Professor of Midwifery says.
Hannah Dahlen, who is also the national spokeswoman for the Australian College of Midwives, said Kristy Jones was likely in pre-labour when she went to Blacktown Hospital on Tuesday morning.
Ms Jones said she insisted she was in pain and would not leave, so she was put in a maternity ward - not the birthing unit. About 18 hours later she gave birth to a baby girl with no staff to support her, Ms Jones said, another patient instead pressing an emergency button and coming to her aid.
But that Ms Jones didn't give birth until the next day showed she did not have to be urgently admitted to the birthing unit when she arrived at hospital and midwives were correct in their initial assessment, Professor Dahlen said.
''One of the first things a midwife would do when a woman comes to hospital in labour is a vaginal examination, and until the cervix is at least four centimetres dilated and there are painful, frequent contractions, you are not in labour,'' she said.
''Pre-labour can last up to a week, and if we admitted every woman to hospital who was in pre-labour wards would be crammed and there would be terrible birthing outcomes.''
The public needed to be educated that some labours do happen very quickly, she said.
''I heard of one woman who was standing at her kitchen sink doing the dishes and the baby just dropped out.
There are double the number of unintended home births than planned ones because there are a group of women who give birth very quickly before they even think about going to hospital.''
However, there was a midwife shortage across the country which led to registered nurses not as trained in child birth stepping in to fill the shortages, she said.
The acting director of nursing and midwifery for Blacktown and Mount Druitt Hospital, David Simmonds, said the unit was fully staffed when Ms Jones gave birth and she was regularly monitored throughout the night.
''We take all patient complaints seriously,'' he said.
If we admitted every woman to hospital who was in pre-labour wards would be crammed
''In this case staff have spoken regularly with the patient, however she has not raised a complaint.
''We are looking into this matter and as with all matters, we will investigate it thoroughly.''
Ms Jones said at one stage she took panadol from her own handbag because nursing staff did not provide adequate pain relief.
NSW Health Minister Jillian Skinner said the hospital was not underfunded.
"The hospital has never had so many resources, more money than ever before," she said.
With AAP


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The New Hampshire Senate
Majority Office
Urges full legislative review prior to final agreement of state-federal partnership
Concord, NH – Senate Majority Leader Jeb Bradley (R-Wolfeboro) a member of the Joint Health Care Oversight Committee, issued the following statement after today's vote allowing Gov. Hassan to send a letter of the intent to the federal Department of Health and Human Services concerning the establishment of a state-federal partnership exchange:
"We appreciate the Governor's staff joining us for today's hearing and their attempts to address some of the key concerns the committee has about proceeding towards a state-federal partnership exchange. However, despite their best efforts, it was obvious to me that far too many questions remain unanswered, and I am uncomfortable putting New Hampshire on the path towards this partnership until more information is available to allow us to fully weigh the costs versus the benefits for patients, providers, and taxpayers.
"Going forward, while the Oversight Committee will continue to have a role in the process, I believe the issue of whether or not to approve a partnership, including how we fund and pay for any obligations assumed under that agreement, is fundamentally a legislative prerogative and not something the Governor can proceed with on her own. In the weeks ahead, I will be working to ensure the proper procedures are established to ensure this issue can be considered by the full legislature."


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In this paper, we present a new cube root algorithm in finite
field $\\mathbb{F}_{q}$ with $q$ a power of prime, which extends
the Cipolla-Lehmer type algorithms \\cite{Cip,Leh}. Our cube root
method is inspired by the work of M\\\"{u}ller \\cite{Muller} on
quadratic case. For given cubic residue $c \\in \\mathbb{F}_{q}$
with $q \\equiv 1 \\pmod{9}$, we show that there is an irreducible
polynomial $f(x)=x^{3}-ax^{2}+bx-1$ with root $\\alpha \\in
\\mathbb{F}_{q^{3}}$ such that $Tr(\\alpha^{\\frac{q^{2}+q-2}{9}})$
is a cube root of $c$. Consequently we find an efficient cube root
algorithm based on third order linear recurrence sequence arising
from $f(x)$. Complexity estimation shows that our algorithm is
better than previously proposed Cipolla-Lehmer type algorithms.


text:
If an item you ordered from TextbookRush does not meet your expectations due to an error on our part, simply fill out a return request and then return it by mail within 30 days of ordering it for a full refund of item cost.
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Description: In 1935, with a doctorate in art history and no prospect of a job, the 26-year-old Ernst Gombrich was invited by a publishing acquaintance to attempt a history of the world for younger readers. Amazingly, he completed the task in an intense six weeks, and "Eine kurze Weltgeschichte fur junge Leser was published in Vienna to immediate success, and is now available in seventeen languages across the world. Toward the end of his long life, Gombrich embarked upon a revision and, at last, an English translation. "A Little History of the World presents his lively and involving history to English-language readers for the first time. Superbly designed and freshly illustrated, this is a book to be savored and collected. In forty concise chapters, Gombrich tells the story of man from the stone age to the atomic bomb. In between emerges a colorful picture of wars and conquests, grand works of art, and the spread and limitations of science. This is a text dominated not by dates and facts, but by the sweep of mankind's experience across the centuries, a guide to humanity's achievements and an acute witness to its frailties. The product of a generous and humane sensibility, this timeless account makes intelligible the full span of human history.
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All the information you need in one place! Each Study Brief is a summary of one specific subject; facts, figures, and explanations to help you learn faster.
List price: $25.00Copyright year: 2005Publisher: Yale University PressPublication date: 10/13/2005Binding: HardcoverPages: 320Size: 5.25" wide x 9.00" long x 1.00" tall Weight: 1.254Language: English
Ernst Hans Josef Gombrich, born March 30, 1909, in Vienna, Austria, was educated at Vienna University where he earned a Ph.D. His career includes terms as Slade Professor of Fine Arts at Oxford and Cambridge universities and as Andrew D. White Professor-at-large at Cornell University. Gombrich's books on art and art history have sold as well as some works of fiction. One of his most popular titles is The Story of Art, which has been translated into 18 languages and sold more than two million copies. Other titles are; Looking for Answers: Conversations on Art and Science (with Didier Eribon), Shadows: The Depiction of Cast Shadows in Western Art, and Gombrich on Art and Psychology. His numerous awards include the Erasmus Prize in 1975, the Hegel Prize in 1976, and the International Balzan Prize in 1985. He holds honorary degrees from various universities, among them Oxford, Cambridge, and Harvard, and from the Royal College of Art (London), 1981.
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Warren Miller Entertainment Releases New Film Trailer for "Like There's No Tomorrow"
It's the 62nd flick produced by Warren Miller/WME, and it looks to be a winner. The teaser for "Like There's No Tomorrow" is jam packed with some seriously kick-ass footage. Look forward to checking out the film this fall.


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Accused cop killer arrested
(Fremont) - Fremont Police have arrested Igmidio Mista, who they say went on a shooting rage Sunday morning inside of Last Call Bar, killing three men including an off-duty police officer.
Fremont police chief Timothy Weirsma says Mista was arrested Monday morning when police went to a home in Fremont. Mista came to the door while police were on the porch. He surrendered without incident.
Mista is being held in jail. Chief Wiersma says Immigration and Customs officers were in contact with the department shortly after the arrest, and the Phillipines consulate will be contacted to see if Mista is in the U.S. legally.
Jose "Andy" Chavez, a 26-year-old Elmore police officer, Ramiro Sanchez, a 28-year-old bartender and Daniel Ramirez, a 25-year-old customer, were killed.
A fourth person was also shot, but he was flown to a Toledo hospital in critical condition.
Fremont is about 35 miles southeast of Toledo.
(Photo courtesy of Fremont Police)
Get breaking news sent to your mobile phone.Text "news" to 21095.
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text:
Visit a Branch!
You Can Do That @ the Library?!
Check Out a "Read to Me" Kit
Books, felt stories, puppets, and music all in one convenient bag! Parents, grandparents, preschool teachers, and family care providers can check out kits on a variety of themes for four weeks.
See our Calendar, Online Catalog or Branch pages for more details and contact information.


text:
Add a touch of class to the kitchen with this Leland Single-Handle Pull-Down Sprayer Kitchen Faucet in Champagne Bronze with MagnaTite Docking. This dramatic kitchen faucet is a perfect combination of traditional style and smart modern functionality, including Delta's exclusive MagnaTite technology. MagnaTite docking keeps the kitchen pull-down spray wand firmly in place with a powerful integrated magnet, so it stays docked when not in use.
- Traditional styling meets modern functionality
- Exclusive MagnaTitespray head docking ensures a snug fit of the wand
- 32 In. minimum supply lines below the deck included
- 1.5 gpm water efficient sprayer assembly available (sold separately)
- Single lever handle for ease of control
- Pull-down spout swivels 360 degrees for easy access to all areas
- 59" long hose provides a 24" reach
- Lifetime limited warranty covers parts and finish defects


text:
Michael Graves wrote:
> I need to setup a backup ISP to ensure reliability of my VOIP gear.
> m0n0 has been really great. I there some way to run it with dual WAN
> connections?
as the FAQ says, "Not yet": http://doc.m0n0.ch/handbook/faq-dualwan.html
which is probably not entirely true. you could always have a second NIC
on a different WAN connection and manually switch over, but that's
probably not what you want. For failover, check out pfsense.


text:
Originally Posted by Dhraiden
This is slightly troubling to read about, and implies that they did not do proper project planning
shouldn't contracts or some kind of enforceable agreements been in place with whomever they hired - regardless of whether the workers are contractors or employees?
Even contractors are supposed to agree to be bound to hit certain deliverables within a certain time-frame, it's basic business sense, no?
I can understand as he says the less costly nature of using contractors instead of employees
but that's less costly sometimes at face value. Here we see an opportunity cost he failed to account for. Hopefully they'll get back on track despite the setback.


text:
Everyone who lives and works at Locking Parklands will enjoy a greener lifestyle. The whole development is characterised by open parkland, trees, shrubs and wildlife habitats. Excellent local services and convenient public transport connections also encourage a more eco-friendly way of life.
With homes and apartments designed to appeal to a wide range of people, as well as a planned school, library, leisure complex and business innovation centre, Locking Parklands will evolve over time into a sustainable new community where people can live, work and relax.
All of the homes reach the Code for Sustainable Homes Level Four – which means that they are 44% more energy efficient than current legislation requires. This is thanks to energy efficient appliances, solar panels for heating and high levels of insulation which in turn means lower carbon emissions and energy bills and a warmer, more comfortable home. As well as homes, Locking Parklands will deliver up to 2,000 new jobs and around 45,000 sq ft of high quality business space. This includes, as part of phase one, a terrace of small office units and detailed planning consent for a 11,000 sq ft office building and 30,000 sq ft Innovation Centre.