text:
Nuplex, which produces and distributes a range of chemical resins for construction or industrial related businesses, is shifting its "centre of gravity" from the dour markets of Australia and New Zealand to Europe and Asia, particularly China and south-east Asia.
Nuplex has operations in Suzhou in East China and Foshan in southern China. Mr Severin said Australian manufacturers must have a presence on the ground in China for customers but the market was far more complicated than the basic volume-based approach.
"People can be a bit starry eyed about the growth. I've always said it is easy to make money in emerging markets but it is a heck of a lot harder to make profits. You really need to understand your markets and be very selective in what you do. A pure volume driven strategy won't work," he says.
"There's a lot of smart local and international competitors in the [China] market."
Mr Severin, who has been at the helm of Nuplex for 2½ years, said the group was close to receiving final approvals for an additional Nuplex plant in Changshu, East China, with the hope of having the factory built by the end of next year.
Nuplex's sales to Asia have risen from 12 per cent to 16 per cent of total sales between fiscal year 2009 and fiscal year 2012 while revenue for Europe, the Middle East and Africa has increased by half to 31 per cent over the same time.
That trend is expected to continue. By the 2015 financial year, Nuplex has forecast 20 per cent of its sales will be generated from Asia and 34 per cent will come from Europe, the Middle East and Africa.
"From an Australian perspective, we have to engage with Asia. Our company is a classic example of that; that's where our centre of gravity will be," he says.
This comes weeks after the federal government published the Asian Century white paper highlighting the opportunity for Australia's economy. Nuplex, which began as an Auckland-based tile and flooring company in 1952, turned to producing resins because it found difficulty in sourcing the product. Initially manufacturing for its own use, Nuplex soon began commercially producing and distributing. Nuplex's resins and polymers are used within the coatings and paints for motor vehicles, tractors, trains, household paint and floors.
Traditionally the group has made the majority of its revenue from Australia and New Zealand, but like the group's shift to Asia and Europe, Australia and New Zealand revenue is expected to contract from 58 per cent in 2008-09 to 37 per cent in 2014-15.
Mr Severin believes the Australian manufacturing sector is going to permanently consolidate but still has a future. The local manufacturing industry has struggled over the past few years with a persistently strong Australian dollar and cyclically low construction activity.
"If it is small and labour intensive, it's going to be tough [in Australia]. If it is a business that is specialised and bulky, then it may be better off," he says. "I think it is certainly going to be smaller than what it was. How much? I won't hazard a guess at that."
Regardless, Mr Severin insists, Nuplex will maintain a manufacturing presence in Australia and New Zealand, albeit a more streamlined operation.
"Our focus here is about being competitive. Returning above cost of capital returns," he said.
The Australian Financial Review


text:
Marketing Manager - Prestigious, Luxury Restaurant Group
- Recruiter
- JFL Search & Selection
- Location
- Mayfair, London
- Salary
- c£40k
- Posted
- 17 Feb 2014
- Closes
- 17 Mar 2014
- Ref
- Sector
- Consumer
- Function
- Manager (In-House)
- Discipline
- Corporate Communications, Digital & Online, Marketing Communications, Press / Media Relations
- Hours
- Full Time
- Contract Type
- Permanent
We are looking for an enthusiastic and energetic Marketing Manager to join an in-house team in the heart of one of London's most attractive and sophisticated boroughs, Mayfair. Our client is a high end, prestigious group who own a number of luxury restaurants and private members clubs in London and America. Our client's Michelin Stared, well known restaurants are situated in some of the most exclusive areas of the city and are among some of the world's most renowned hotels, restaurants and shops. This position requires someone who has experience in a similar role and therefore possesses superb exclusive/ luxury contacts within this sector. This is an exciting opportunity to help develop and grow the company and their restaurants into a leading competitor in this sector and be involved in a fantastic, elite organisation.
As Marketing Manager you will be help promote the group's vision and philosophy of providing a world class service. The successful candidate will be creating, organising and executing first class events and original marketing campaigns. Researching and realising potential marketing opportunities to help to promote and grow the organisation is also essential to this position. The Marketing Manager would also be responsible for updating and writing all of the marketing materials and websites. The candidate will have to have a real passion for the industry and be able to analyse and report on the trends and be able to cross-sell between the restaurants and customers.
The ideal candidate will:
- Have a passion for food, restaurants and wine
- Possess excellent media relations and contacts, particularly with food and travel editors
- Be able to network and connect the business with relevant people
- Be Social Media Savvy
- Speak French, although this is not essential
This is a fantastic opportunity for a passionate and driven candidate to join an international company. If you think you have the experience and skills necessary for the role, please contact firstname.lastname@example.com or call 020 7009 3512.

subset: commoncrawl


text:
Thursday, June 07, 2007
The shooting a film involves a lot of different locations, some of them pretty weird too. Mumbai is famous for its 'Chor Bazaar' and never has any one shot there before. The reason for this is genuine too. Actually, it is difficult to shoot there as it is an illegal market and no shopkeeper wants to bring his shop on camera.
But, the shooting of the movie 'Journey.... Bombay to Goa' began at the very 'illegal' place. It was an important sequence in the film, as the bus used in the movie is from 'Chor Bazaar'! Despite being such an important part of the film, the vehicle does not belong to any company or brand as it has been assembled using parts bought from this very 'chor' bazaar of Mumbai.
In the movie, the bus has been custom designed by Vijay Raj and the front portion is like that of a kangaroo and the roof is German-styled. Going by demand of the story, the crew was forced to shoot there. Talking about his experience, laughter champion winner comedian Sunil Pal had says, "It is not easy to shoot in 'Chor Bazaar', people do not co operate and are pretty reluctant."
The cast and the crew were mentally prepared for any kind of trouble. But to everyone's surprise the shopkeepers were extremely co-operative with them and lent their complete support. The shopkeepers liked the concept of the film and did not interrupt the shoot at any point of time.
They not only showered their love and blessing on the actors, but also gave then a treat! All the actors were happy that they got an opportunity to shoot at 'Chor Bazaar' and know the place closely. Sunil was so impressed by the variety of things that were available at the place that he even suggested to rename the place as the 'Thief Shopping Mall'!
Recent Stories
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text:
Seattle-based Redhook Brewery has been around for 30 years now, and its 30th expression of its seasonal Winterhook brew is now on the market. Redhook tweaks the recipe for Winterhook every year, and this year it comes forward with a burly, slightly smoky winter ale. Decked with molasses from the get-go, this malt-heavy beer offers notes of coal fires, bitter greens, cloves, and forest floor. It tastes stronger than it is — just 6% abv — which makes it a better choice for sipping on in this post-holiday-meal aftermath. All in all, a burly, but not overpowering, little number that dark beer fans should enjoy quite a bit.
6% abv.
B+ / $NA / redhook.com
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text:
|Fravel, Deborah
|Bao, Jian
Submitted to: Verticillium International Symposium Proceedings
Publication Type: Abstract Only
Publication Acceptance Date: 9/15/2001
Publication Date: N/A
Citation: N/A Interpretive Summary:
Technical Abstract: Talaromyces flavus (anamorph = Penicillium dangeardii) is a soil-inhabiting fungus that controls diseases caused by Verticillium spp. This study was undertaken to determine the genetic diversity of T. flavus and other species of Talaromyces, as well as to determine the relatedness of T. flavus to a published ITS sequence for a human pathogen, Penicillium marneffei. Talaromyces spp. were from 18 countries (31 isolates) and from 22 states in the US (29 isolates). Authentic cultures of T. emersonii, T. helicus, T. trachyspermus, and T. wortmannii were obtained from ATCC. Growth rate of each strain at 22 and 37 C was determined. DNA was extracted from all strains and the ITS1 and ITS2 regions, as well as the gpd (glyceraldehyde-3-phosphate dehydrogenase) region, were amplified and sequenced. There was less variability in ITS regions than in the gpd region. Correlation between dendrograms for ITS and gpd sequences was poor, as was correlation between ITS and gpd sequences and gross morphology. Dendrogram using ITS sequences indicated that there were 2 major groups. The larger ITS group contained 38 isolates, including T. flavus Tf-1 and another biocontrol strain.


text:
Walking Tours
Legends of St.Petersburg
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About Us
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Apartments in St.Petersburg, Russia
Dear Friends!
We may offer you
apartments on our site both for long term rent and for short term rent.
We may also find other apartments for long and short term rent according to your requirements not just on our site, but in the professional daily updated real estate database.
Daily rent fees
vary depending on the quantity of days and the season. No extra commission above daily fees on the site.
Monthly rent fees
on our site are mentioned for
long term rent
like 5-8 months or a year, rent fee for 1 month may be higher. A number of apartments may be rented monthly just in a low winter season, but daily in summer.
One time agency commission for long term rent may be from half of a monthly rent fee (and even less for shorter terms) to a monthly rent fee.
To reserve an apartment daily
one must send one day rent fee deposit according to our request. Sometimes deposits for daily rent are higher.
Reservation deposit
is given to the landlord of the reserved apartment and in case of cancellation of the trip, the deposit is used by the landlord as the reimbursement of declined offers of other candidates.
Check in
is usually 12.00 - 2pm,
check out
is usually noon, though it is flexible when it is possible.
, even not mentioned on the site, is usually provided in all the apartments, and it is not a problem to set it these days.
Some of the apartments may be not available (rented) so please,
contact Irina
Skype iribor0805 , ph.+7-921-3033542
and ask her for all particular details about the flat you would wish to rent.
Please contact Irina
for more information about these apartments. If you have
other preferences,
also contact Irina and we will try to
find exactly what you need.
One room apartments
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Two and more bedroom apartments
Homestay (Rooms for Rent)
One bedroom = two room apartment in Russia
Two bedroom = three room apartment
Three bedroom = four room apartment, etc.


text:
1997-11 --
March 31, 1997
David Hosansky
UCAR Communications
P.O. Box 3000
Boulder, CO 80307-3000
Telephone: (303) 497-8611
Fax: (303) 497-8610
E-mail: email@example.com
What seasonal weather patterns have placed so much of the country at risk for flooding? How does society exacerbate flooding and its dangers? What is the difference between a flash flood and a river flood? To help you answer these and other questions, below is some background information on U.S. flood risk from a newly published report by Roger Pielke, Jr., of the National Center for Atmospheric Research (NCAR) in Boulder, Colorado. Also below is a list of flood and flash-flood experts and some relevant World Wide Web sites. NCAR is operated by the University Corporation for Atmospheric Research (UCAR) under sponsorship by the National Science Foundation.
story ideas and relevant links
NWS Office of Public Affairs
Bibliography of research on water resources
U.S. Geological Survey/Colorado District
plain management
U.S. Army Corps of Engineers/Flood Plain Management Services Program
Background on flood hazards, insurance, and mitigation
Federal Emergency Management Agency
Home page and National Flood Insurance Program
What are the elements of a flash flood and a river flood? Flash floods are short-term inundations of small areas such as a town or parts of a city, usually by tributaries and creeks. Heavy rain in a few hours can produce flash flooding even in places where little rain has fallen for weeks or months. If heavy rainfall occurs repeatedly over a wide area, then river or mainstem flooding becomes more likely, in which the main rivers of a region swell and inundate large areas, sometimes well after rainfall has ended. The 1993 Midwest floods were caused by 77 events over several months where rainfall of greater than one inch occurred over areas 100 to 200 miles wide and 400 to 600 miles long. Both flash flooding and river flooding threaten life and property, although the former causes more deaths and the latter more property damage.
Are the death tolls from U.S. floods increasing? On average, U.S. flooding kills more than 100 people a year--more than any other single weather hazard, including tornadoes and hurricanes. The average flooding toll has increased in recent decades while deaths from tornadoes and hurricanes have dropped. Almost half of all flash-flood deaths are connected to stream crossings or highway travel. Victims often underestimate the power of water when driving into flooded areas. It takes only 18 inches of water to float a typical automobile.
How can a 100-year flood occur more than once in a short period? A 100-year flood is one that has a one-percent chance of being exceeded in a given year. Few locations have rainfall records of more than a century, so 100-year flood values are estimates rather than certainties. Changes in watershed management, land use, and the like can affect streamflow characteristics and alter the likelihood of a given flood. Moreover, climatic patterns themselves can change. There is nothing to prevent more than one "100-year flood" from occurring at a given spot over a century.
Is global warming causing more floods? Because flood risk is the result of both environmental and societal factors, it is difficult to single out the impact of climate variations. According to the United Nations Intergovernmental Panel on Climate Change, the average global temperature at the surface has increased about 1.0 degree Fahrenheit this century. At the same time, according to NOAA, there has been a steady increase in the area of the United States affected by extreme precipitation events (more than two inches of rain in one day, or the equivalent in snow). However, flood reports have not increased uniformly across the country. For instance, streamflows in the Colorado River basin have decreased over the past 60 years. Any alteration of global climate can bring either an increase or decrease in precipitation or flood events at a given location. Current computer models of climate are unable to project local variations with certainty.
Are societal choices increasing flood risk? According to a report by the U.S. Congress's Office of Technology Assessment, "despite recent efforts, vulnerability to flood damages is likely to continue to grow." The factors cited include
To receive UCAR and NCAR press releases by e-mail,
contact Milli Butterworth
telephone 303-497-8601 or email@example.com
The National Center for Atmospheric Research and UCAR Office of Programs are operated by UCAR under the sponsorship of the National Science Foundation and other agencies. Opinions, findings, conclusions, or recommendations expressed in this publication do not necessarily reflect the views of any of UCARs sponsors. UCAR is an Equal Opportunity/Affirmative Action employer.


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Christmas Under Siege: Israeli Pull Back Itstroops in Bethlehem But Warn Residents That This Willbe No Ordinary Christmas; We Go to Manger Square Andthen Talk to the Founders of the Palestinianinterna
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While employers have a number of legal obligations, they do have the right to ask certain questions about an employee or potential employee's mental health condition.
Where more information about a condition is legitimate, necessary and desirable, an employer is permitted to ask an employee or potential employee for details. This may be:
If you're an employer in this position, the overall test is whether your enquiries are for a 'legitimate' purpose. For example, it might be legitimate to ask an employee questions about their medication if the job involves operating machinery.
If you do ask your employee for information, you must maintain confidentiality and protect his or her right to privacy. This means protecting the information against improper access and disclosure.
Under the Disability Discrimination Act 1992 (Cth), it is illegal for an employer to discriminate against someone on the grounds of disability – including a mental health condition.
This means you, as an employer, must offer equal employment opportunities to someone with a mental health condition. If a person can fulfil the 'inherent requirements' of the job, he or she should have just as much chance to do that job as anyone else. These inherent requirements will be different for each role and include the ability to perform core tasks, work effectively with the team and work safely.
These laws against discrimination apply:
These laws also apply to contractors and parties to a partnership agreement. They govern the actions of employers, employment agencies, federally-registered trade unions and bodies with control over professional, trade or occupational qualifications.
For many people experiencing a mental health condition, small changes to the working environment will be enough to ensure they have an equal opportunity to perform the requirements of the job.
If you're an employer, you're required by the Disability Discrimination Act 1992 (Cth) to make reasonable adjustments so that a person with a mental health condition can productively perform the functions of a job.
This might include:
The individual situation will dictate what kinds of adjustments are reasonable in the circumstances. In most cases, the employee involved will be able to identify what changes are required. If the requested adjustments would impose unjustifiable hardship on your organisation or change the role's inherent requirements, there is no obligation to implement them.
The Australian Human Rights Commission has developed a brief guide to the Disability Discrimination Act 1992 (Cth).
Under each state and territory's work health and safety legislation, there are obligations to ensure (so far as is reasonably practicable) the health and safety of workers and others in the workplace, such as visitors and customers. 'Health' is defined in the Work Health and Safety Act 2011 as both physical and psychological health.
The employer, or person in control of the business, should ensure health and safety so far as is reasonably practicable by:
At the same time, there are obligations under work health and safety legislation for workers and all other people within a workplace. Under the Disability Discrimination Act 1992 (Cth), an employee's ability to work safely is an 'inherent' or essential requirement of any job. If an employee's mental health condition could reasonably be seen to cause a health and safety risk for other people at work, then failing to disclose that risk could be a breach of their obligations under work health and safety legislation.
Common risks to mental health in the workplace include job stress, bullying and harassment, and workplace trauma. Risks should be actively managed by eliminating or minimising the risks, so far as is reasonably practicable.
Reasonably practicable means actions which are reasonable, or were at a particular time, taking into account all relevant matters including:
Download Safe Work Australia's
reasonably practicable guide
Under the Australia-wide Privacy Act 1988 (Cth) and similar legislation in some states and territories, employers must observe confidentiality and respect the privacy of each employee. This means that an employee's mental health condition can't be shared with anyone without his or her permission. Any information can only be used for the purposes for which it was disclosed, such as arranging adjustments in the workplace to support the employee.
Communicating any adjustments to working conditions is a balancing act. Employers need to keep the team sufficiently informed about the changes, without compromising the privacy of the employee.
The Disability Discrimination Act 1992 (Cth) also requires employers to prevent harassment to an individual experiencing a mental health condition, including physical and verbal abuse.
In practice, this means it's important to be proactive in identifying conflicts, gossip and bullying in the workplace and act quickly to resolve any issues.


text:
Tuesday, November 4, 2008
Welcome To Pittsburgh Steeler Blogs
Welcome To Pittsburgh Steeler Blogs, where we aggregate all of your favorite Steelers blog feeds all in one easy to find site. You will find links updated daily to all the major Pittsburgh Steeler fan blog sites. Check back daily for easy access to breaking news on the Pittsburgh Steelers.
Posted by Steelers Blog at 1:37 PM 2 comments:
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text:
Analyzing a health care intervention to provide policy-makers with information on mechanisms for improving disease management
The Foundation's program, State Health Access Reform Evaluation (SHARE), was designed to support research and evaluation of state health reform initiatives and develop an evidence base for future state and federal reform initiatives.This project is part of a larger initiative to measure the impact of several policy interventions to increase access to and use of statins by diabetic enrollees in Oklahoma's Medicaid program. The study's design and administration, as well as its data collection, were supported with other funding. This grant supports the analysis of the data and the dissemination of findings from the study. The project has important implications for policy makers seeking to control costs and improve outcomes for their Medicaid population. The project builds off work done by Katherine Baicker, Ph.D., as an expert consultant under the Medicaid Leadership Institute. The deliverables will include: (1) a detailed report; (2) an article for a peer-reviewed health policy journal; and (3) an issue brief designed for policy makers in Oklahoma and other states.
Grant Details
Amount Awarded $50,000.00
Awarded on: 7/27/2010
Time frame: 9/1/2010 - 8/31/2012
Grant Number: 68057
Harvard University T. H. Chan School of Public Health
677 Huntington Avenue
Boston, 02115-6028
Katherine Baicker
Project Director


text:
Abanking reform package from government, a Senate inquiry, major bank annual general meetings and finally detail of capital and liquidity regulations designed to make the global financial system safer.
In order, these events of last week were reasonable, a waste of our taxes, predictable and critical.
The Senate inquiry, like the Swan package a symptom of the chronic financial myopia in Australia, has drawn some excellent submissions as well as special pleading. And hopefully, with the representations of the Reserve Bank, Australian Prudential Regulation Authority, Treasury and others, has laid to rest ludicrous claims of gross dysfunction in Australia.
To precis the evidence, there is room to remove some impediments to competition but overall the competitive landscape is healthy, banks are not profiteering, the global financial crisis was well handled in Australia and the pendulum is now starting to swing back in favour of competition from overriding concerns about stability.
The bank AGMs emphasised political point scoring over the banking system has real world consequences in that it heightens anxiety in global investors who must fund Australia's current account deficit via the banks.
All these events, however, are dwarfed by the significance of the announcement on Thursday by the Basel-based Bank for International Settlements of rules for liquidity and capital. And locally, the response by APRA and the RBA. It is global regulation that will shape Australian banking.
The critical issue for us was liquidity, as globally this standard hinges on banks holding a supply of very secure assets easily convertible to cash and – despite worries about sovereigns such as Greece and Portugal – is essentially government debt. And which, despite the misinformation of the opposition, Australia doesn't have much of.
During recent interviews with the European Central Bank, European Union finance officials and Group of 20 leading economies officials, it was made very clear to me that the Australian situation regarding liquidity was well understood.
The Europeans accepted Australia had an "objective" case for variations to the rules and APRA and the RBA would determine an appropriate solution to maintain the object of the liquidity rules was satisfied.
APRA and the RBA outlined a liquidity facility that would provide a special market at a fee for qualifying securities if they couldn't be secured elsewhere.
"The commitment fee is intended to leave participating approved deposit-taking institutions with broadly the same set of incentives to prudently manage their liquidity as their counterparts in jurisdictions where there is an ample supply of high-quality liquid assets in their domestic currency," they said.
This is precisely the intention of global regulators. They set rules but local regulators, with the resources and market knowledge, determine local implementation.
As the Australian statement said: "Fiscal prudence by a succession of governments means that the supply of government securities in Australia is relatively limited. A second level of eligible liquid assets . . . is also in short supply in Australia . . . To address this situation [Basel] incorporates scope for alternative treatments."
Hopefully the members of the Senate banking inquiry read this because there's little evidence to date they've sought to properly inform themselves about the issues at all. This is an inquiry into competition but the competition regulator hasn't even been heard.
Meanwhile, the hearings descend into puerile political point scoring while the meter keeps ticking for us taxpayers.
Take for example Liberal senator
Considering return on taxpayer equity in this inquiry, my view is McGauran has been a value destroyer. Does Hockey have such a glass jaw that Smith's line demanded inquiry time be wasted on it?
One can only imagine how the senator would have coped with Paul Keating. A shiver looking for a spine?
And on that note a Merry Christmas and Happy New Year to all readers and may Santa fill the stockings of the senators with plenty of BIS reports and a map of the world.
The Australian Financial Review


text:
Originally written on Pro Boxing Fans | Last updated 9/4/14
CANNES, FRANCE - MAY 18: Actor Kristofer King, Julio Diaz, actress Mercedes Cabral, Gina Pareno, actor Coco Martia and actress Jacklyn Jose attend the 'Serbis' photocall at the Palais des Festivals during the 61st International Cannes Film Festival on May 18 , 2008 in Cannes, France. (Photo by Sean Gallup/Getty Images)
Three of the fighters who'll be fighting on CBS Television Network's portion of an unprecedented boxing marathon on CBS and SHOWTIME® this Saturday, Dec. 15, at the Los Angeles Memorial Sports Arena participated in a media workout Monday at the Ponce De Leon Boxing Gym in Montebello, Calif. Take a look at photos and quotes from the training session right here. The three – undefeated IBF Bantamweight World Champion Leo Santa Cruz (22-0-1, 13 KO's), of Los Angeles, his challenger, unbeaten Alberto Guevara (16-0, 6 KO's) of San Diego, Calif. and 2012 U.S. Olympian Joseph "Jo-Jo" Diaz, of South El Monte, Calif. – each worked out for approximately 30 minutes. LEO SANTA CRUZ "Considering that six months ago I was just a guy fighting on undercards to now being picked to headline and defend my title on free network television is hard to believe, but I'm so happy. It is a tremendous honor and something I am not taking lightly. I really want to thank my promoter, Golden Boy, my ad...
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text:
Eurogamer: The review scores came in and no doubt they were a bit lower than you hoped. Was there a lot of deflation in the office?
Keith Hladik: We were pleased with the first announcement of the sales. I don't recall exactly, but it was about 100,000 for the first few weeks. Coming from where we were at – we're an independent studio and this is our first IP – we had pretty decent sales and the reviews were fair.
I don't recall anyone being down. We already knew we were going to make a sequel, so the fallout from that was we were determined to make the sequel way better than the first one.
Kevin Sheller: I'm not going to make a comparison to Grand Theft Auto... but okay, I'm going to make a slight comparison to Grand Theft Auto. The first two GTA games, nobody knows anything about them, right? Grand Theft Auto 1? Nobody even said that word. They never said two either. It wasn't until Grand Theft Auto 3 that people really got excited about what they were doing.
We look at the first Conduit as our learning experience, our foundation work – and we'll see where we go from there.
Eurogamer: How do you think it would have played out if Eric and Matt hadn't gone to E3 and set the hype train in motion? If you'd just quietly got on with it instead?
Kevin Sheller: It's hard to imagine. What happened is what happened, y'know? It worked for us in that we secured publisher assistance, because we generated a lot of excitement. We had a lot of offers from many different parties. So that gave us an opportunity. If we'd been quiet about it I don't think we would have been able to publish it.
And most of the time publishers want every SKU imaginable. They want the PS3 and the 360 and the Wii and so on and so forth, because if they're going to make that investment they're going to want to see a big return. It would have been a really hard sell to go out and say, "We're going to make this awesome thing for Wii only." They'd have been like, "Hmm, yeah, sure you are."
Eurogamer: Obviously the original didn't exactly sell millions of copies. How did you get the sequel green-lit? Was it locked in before the first game was even out?
Kevin Sheller: It was always a two-game contract.
Eurogamer: Take us through the things that the sequel is doing that the original didn't. What are the key improvements?
Kevin Sheller: Let's break it down, because man, there's so much. If you start off with single-player obviously it's a longer gameplay experience. We have a much richer story, cinematics, characters that you're going to see and interact with that we didn't have in the first game. The boss battles are huge.
Keith Hladik: The first game was mainly set in Washington DC, but this one is set in China, Siberia, DC, in the middle of the ocean, and some other locations we can't talk about right now. And we have a lot more weapons. You can take more weapons into each level, you can pick which weapons to take into each level.
Then there's multiplayer. The big thing, there is split-screen. A lot of people wanted it in the first game but we just didn't have time. So that was one of the first things we worked on. And there's also split-screen co-op in the Invasion mode where one to four people can fight wave after wave of enemies.
There are over a dozen maps. Some are returning from the first game but they're mainly all new. There are all the weapons from the first game and around six or so new ones.
Kevin Sheller: And the ones from the original are all upgraded and improved.
Keith Hladik: There are suit upgrades too that can, say, make you run faster or do more damage with certain weapons. We also allow voice chat with rivals now so you can befriend random people online you play against using the Headbanger headset.
Eurogamer: Clearly you're doing you're best to make sure it's a superior game, but is that enough? You've got the continued reluctance of Wii owners to buy into third-party games, dwindling enthusiasm for the console in general, not to mention gamers who might feel burned by the original.
Kevin Sheller: One of the things you already called out in one of your earlier questions is we hyped up the first game quite a bit. We've done the opposite with this one. We've been subtle about it. Here's what we're doing, tell us what you think. I'm hoping it will have that surprise element.
Keith Hladik: And we're hoping word of mouth can play its part. If you remember in the nineties when GoldenEye first came out, I didn't hear about it. People were talking in school and I was like, "Maybe I should get that game". So that's one thing I'm personally hoping picks up.


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Ceramics! It's art that you can eat on, drink from and cook with, and put flowers in, and more. If you're curious about what your friends and neighbors can do with kilns and clay, this week is the time to find out.
The Pottery Guild of Aspen holds its annual Christmas sale at the Aspen campus of Colorado Mountain College (CMC). The opening reception — including wine and food — is on Wednesday Dec. 12 from 5 - 7:30 p.m. The sale continues Dec. 13 and 14 from 10 a.m. - 7 p.m. The show includes clay sculpture, handmade pottery, dinnerware, mugs, platters, and casseroles. Some of the local ceramic artists presenting are Kathy Mann, Scotty Cathart, Dianne Light, Georgann Moore, Cindy Kirkwood, Tammy Lane and Mary Ballou, with CMC faculty including Anne Goldberg, Kay Cesark and H.P. Bloomer. Call 970-925-7740 for information.
The intellectual stimulation of Aspen Institute panels isn't solely a summer tradition. Aspen's nonprofit brain center has seminars and programs running year-round. Among the highlights of this winter's public presentations is Thursday Dec. 13's "Legacy of Rome" panel in the Koch Building on the Institute's Aspen Meadows campus. Experts will discuss Rome's enduring influence on world architecture, religion, sculpture, politics painting, commerce and law.
The panel includes author/professor Bill Cook of SUNY Geneseo, Jeremy Hartnett of Wabash College and New York Times bestselling author Ross King. King's books include "Brunelleschi's Dome," "Michelangelo and the Pope's Ceiling" and the newly released "Leonardo and the Last Supper."
Tickets are $10 in advance and $15 at the door, available at www.aspenshowtix.com [1], the Wheeler Opera House, or at 970-920-5770. It starts at 5:30 p.m. in the Koch Building.
The Isis Theater downtown is launching a new series this week, broadcasting Metropolitan Opera performances live and in high definition. It kicks off on Saturday, Dec. 8, with Verdi's "Un Ballo in Maschera" at 10:55 a.m.
"We strongly feel that Aspen will embrace these offerings and we are honored to be able to present them," says Metropolitan Theatres spokesman Alan Stokes.
The series continues all winter with broadcasts on Dec. 15, Jan. 5. and 19, Feb. 16, March 2 and 16, and Apr. 27.
Box lunches will be served from a local restaurant for Saturday's show. All seats are $20. Tickets are available at the box office of the Isis Theater or online at www.metrotheatres.com [2].
[1] http://www.aspenshowtix.com
[2] http://www.metrotheatres.com


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Independent Foreign Fiction Prize 2015 - shortlist announced
First-time translation from Equatorial Guinea features on the 25th anniversary shortlist.
International literary giants Haruki Murakami and Erwin Mortier have made the shortlist for the 2015 Independent Foreign Fiction Prize. They are joined by German authors Jenny Erpenbeck and Daniel Kehlmann, as well as the Prize's first shortlisted book from Equatorial Guinea, courtesy of Juan Tomás Ávila Laurel. They are joined on the list by Colombian Tomás González.
The shortlist is:
- By Night the Mountain Burns by Juan Tomás Ávila Laurel translated from the Spanish by Jethro Soutar (And Other Stories)
- Colorless Tsukuru Tazaki and His Years of Pilgrimage by Haruki Murakami translated from the Japanese by Philip Gabriel (Harvill Secker)
- The End of Days by Jenny Erpenbeck translated from the German by Susan Bernofsky (Portobello Books)
- F by Daniel Kehlmann, translated from the German by Carol Brown Janeway (Quercus)
- In the Beginning Was the Sea by Tomás González translated from the Spanish by Frank Wynne (Pushkin Press)
- While the Gods Were Sleeping by Erwin Mortier translated from the Dutch by Paul Vincent (Pushkin Press)
Find out more about this year's shortlist
Over 25 years the Prize has showcased the work of newly-translated authors. Two writers on this year's shortlist will be new to English speakers: both Spanish-language writers but both from outside Spain: Colombian Tomás González (In the Beginning Was the Sea) and Juan Tomás Ávila Laurel from Equatorial Guinea, Africa's only Spanish-speaking country.
By Night the Mountain Burns is only the second novel from Equatorial Guinea ever to be translated into English from that country, and was selected by the publisher, And Other Stories, through its international reading groups programme, which invites readers to propose suitable titles for translation.
Claire Shanahan, non-voting chair of judges and Head of Arts at Book Trust says:
As we celebrate the 25th anniversary of the Prize, it's poignant to reflect on the consistent quality of good writing and translation being brought to readers from around the world. Over the past five years, we've received 595 submissions in 44 different languages, highlighting the richness and variety of fiction from across the globe.
Books play an increasingly important role in our understanding of the world around us. They start an introduction into a wide tapestry of knowledge and culture, which can help readers understand who they are and the place they have in the world. This shortlist encapsulates the excitement of looking outwards and discovering new and different voices.
Kehlmann, Erpenbeck and Murakami have all been shortlisted for the prize before, as have their respective translators Carol Brown Janeway, Susan Bernofsky and Philip Gabriel. Frank Wynne who won in 2005 with his translation of Windows on the World, written by Frédéric Beigbeder, appears again on the shortlist for his translation of In the Beginning Was the Sea
This year's shortlist was chosen by a panel of five judges from 111 titles from 28 source languages.
The 2014 Independent Foreign Fiction Prize was won by Iraqi writer Hassan Blasim and translator Jonathan Wright for The Iraqi Christ, published by Comma Press. Previous winners of the Prize include Orhan Pamuk and translator Victoria Holbrook in 1990 for The White Castle; W.G. Sebald and translator Anthea Bell in 2002 for Austerlitz; and Per Petterson and translator Anne Born in 2006 for Out Stealing Horses.
Key dates:
- Shortlist event at Foyles (London Book and Screen Week) - Thursday 16th April. Buy tickets.
- 'All Must Have Prizes - the unstoppable rise of translated fiction' - joint event with English PEN at the London Review Bookshop - 26th May
- Award ceremony - will be announced at a special ceremony at RIBA on Wednesday 27th May
- IFFP event, Hay Festival, 28th May, 7pm (to be confirmed)


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Now You Can Skype On Facebook
Facebook has announced that it's users will now be able to video call using Skype. This will allow users to chat with a friend visually without having to have a seperate Skype account. Great!! Now I'll have to take a shower and fix my hair when I log onto Facebook!! lol
Mark Zucherberg talks about to new Skype video calling element….


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This budget has what economists and accounting types call "fiddles".
The issue is how many and whether there are more than usual.
Some in the 2012-13 budget papers are bold, such as moving $1.1 billion in grants to local governments from 2012-13 to 2011-12.
Some are more subtle, like postponing the trade cadetships program in order to move $9.4 million out of 2012-13. The government says the delay will allow it to incorporate the recommendations of an advisory panel.
Those adjustments are on display in Budget Paper 2, which lists formal policy decisions, including revenues raised. These include taking a $200 million dividend from the Export Finance and Insurance Corporation, and a $100 million one-off dividend from the national terrorism insurance scheme, the Australian Reinsurance Pool Corporation.
But in the murky depths of the budget, the aggregates suggest much more has been done.
Cash from "dividends and other" is $5 billion higher in the surplus year than years before. It is $21 billion in 2012-13, up from $16 billion in the preceding year. It falls away again to $16.5 billion in 2013-14.
The opposition supports the push to get to surplus, but says the government's figures aren't real.
"It is a 'cook the books' budget," shadow treasurer
In 2010, the government promised the budget would be back in surplus in 2012-13. Since then, revenues have not grown as fast as expected, and the merits of sticking to the promise were called into question. Removing spending from the economy could damage growth.
Selling the budget, Mr Swan described the commitment to get back to surplus as "one of the best policies we've put in place" and "a powerful signal of credibility to nervous markets".
Another subtle but important factor in delivering the surplus is the forecast for GDP growth in 2012-13. The estimate of 3.25 per cent is high, compared with current year growth and forecast growth in 2013-14, both 3 per cent.
JP Morgan economist Stephen Walters said the growth forecast was above his own.
"It's optimistic but not out of the ballpark," he said, noting that it relied on the market pricing of two more interest rate cuts this year.
"It's a bit of a circular argument. If you are getting 3.25 per cent growth, why is the RBA cutting?"
HSBC economist Paul Bloxham said the 3.25 per cent growth might happen, but was unlikely to happen in the same year the Reserve Bank cut rates sharply and a surplus was achieved. He said the planned surplus was the most likely to slip.
He also cast doubt on the government relying on highly contingent interest rate cuts.
While the budget papers are produced in Treasury, they are signed off by the Treasurer and he must publicly defend the numbers.
The papers show the effect of a different GDP growth rate on the budget balance.
The scenario is higher growth through higher labour productivity and labour market participation.
It finds higher real GDP growth by 1 per cent benefits the budget by $3.3 billion. And of course, forecasting higher GDP in the first year flows through to higher results in all the later years. The benefit in 2013-14 is $4.4 billion, in the hypothetical scenario.
The Budget growth forecasts fit in the middle of the Reserve Bank forecasts in last week's statement on monetary policy. But the Government does not always cleave to those forecasts. In 2013-14 it is more conservative than the Bank by half a percent and in 2011-12 it is more optimistic by 0.25 per cent.
The Government's growth projections come in the same year it forecasts increasing unemployment and shrinking public expenditure ("final public demand" subtracting 0.5 per cent from GDP next year), as both states and federal governments go on a savings spree.
The Australian Financial Review


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This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
Besides being the favorite carbon and energy source for the budding yeast
The budding yeast
When cells are grown on glucose and no other nutrient is limiting, then a second phase of growth takes place where yeast cells use the ethanol they produced during the first phase of growth. This pattern of growth (called post-diauxic growth, solid yellow area in
To be effective, the above-described strategy requires accurate monitoring of extracellular conditions and a fast and coordinate way to regulate gene expression so to optimize glucose utilization and achieve the highest possible growth rate by fine tuning cell growth (
Since glucose is its preferred carbon source and it is central to its ability to survive in the wild,
Glucose import into the yeast cell occurs via facilitated diffusion through a group of membrane-spanning proteins, termed hexose transporters (encoded by
None of the transporters is individually essential for viability or growth on glucose [
Since the diverse carriers exhibit different kinetic properties, each of them appears particularly suited for a specific growth condition: for instance, Hxt1, a low affinity, high capacity transporter, is most useful when glucose is abundant, whereas Hxt6 and Hxt7, two high affinity carriers, are necessary when the sugar is scarce [
Yeast cells express only the glucose transporters most appropriate for the amount of sugar available at any moment in the environment. This pattern is due to the combined action of different regulatory mechanisms, including transcriptional regulation of the major
The transcriptional regulation of
Other mechanisms appear to contribute to regulation of
Despite their high similarity to the Hxt glucose transporters, Snf3 and Rgt2 seem to have lost the ability to import sugars inside the cell [
Distinctive features of both Snf3 and Rgt2 are their long cytoplasmic C-terminal tails (∼200 aa) that play an important role in glucose signaling [
It is generally accepted that glucose signaling by Snf3 and Rgt2 is a receptor-mediated process similar to hormone signaling in mammalian cells [
The central players downstream of Snf3 and Rgt2 are Rgt1, a transcriptional repressor which negatively regulates the expression of
Rgt1 contains a C6-(Cys6 Zn2) 'zinc cluster' DNA-binding domain in its N-terminus [
The two co-repressors Mth1 and Std1 bind to a common site on Rgt1: Mth1 serves primarily to maintain repression of
When glucose becomes available, it binds to the Snf3/Rgt2 sensors on the plasma membrane [
Multiple evidences support the notion that PKA contributes to glucose induction of
Therefore, two distinct glucose-induced events must occur for the removal of the Rgt1 repressor from the
In yeast, a major signaling pathway activated by glucose is the cAMP/protein kinase A pathway, which regulates many aspects of cellular physiology, including growth, proliferation, metabolism, stress resistance, aging, morphogenesis and development according to nutrients availability (
Ras proteins are required to maintain basal adenylate cyclase activity and are thus essential for cell viability. Besides intracellular acidification [
cAMP-dependent protein kinase (PKA) is a conserved serine/theonine kinase that exists in its inactive status as a heterotetrameric holoenzyme composed of two catalytic subunits (encoded in yeast by the three closely related genes:
At least two different mechanisms regulate the subcellular localization of PKA: cAMP controls the localization of the Tpks catalytic subunits, whereas the carbon source determines that of the Bcy1 regulatory subunit; in addition, Bcy1 apparently determines the localization of the TPK subunit associated with it [
Activation of PKA elicits dramatic changes in the transcriptional program and in the activity of the biosynthetic machinery, which help the yeast cells to adapt to changes in the nutrient status. Several well known targets of PKA include glycolytic and gluconeogenetic enzymes, proteins involved in the metabolism of storage carbohydrates, transcription factors regulating stress response, ribosomal biogenesis, and carbohydrate metabolism [
The GPCR (G-protein coupled receptor) module composed by the Gpr1 receptor and its cognate G protein Gpa2 defines a glucose-sensing system that works in parallel with Ras to activate PKA (
The Gpr1-Gpa2 module is responsive to glucose and sucrose but not to structurally similar sugars such as fructose or to glucose analogues, while mannose acts as a potent antagonist of both sucrose and glucose induced cAMP signaling [
Gpr1 senses sucrose and glucose with high (0.5 mM) and low (20 mM) affinity, respectively. Detection of low amounts of sucrose, a less-preferred sugar, may be important for the survival of yeast cells in the wild, where long periods of nutrient starvation alternate with intervals of nutrient abundance. On the other hand, the low affinity of the GPCR system for glucose may fit with the notion that its major function is confined to cAMP synthesis stimulation during the transition from respirative growth on a non-fermentable carbon source to fermentative growth on glucose [
Gpa2 is an atypical Gα protein for which no canonic Gβ and Gγ cognate subunits have been identified. Recent findings suggest that Asc1 (a protein with no homology to the classical Gβ subunits but which possesses their characteristic 7-WD domain structure) may act as a substitute Gβ subunit for Gpa2 to negatively regulate the glucose signalling [
Gpa2 also interacts with Krh1 and Krh1, two kelch repeat proteins originally thought to mimic Gβ subunits [
Based on its interaction with the Kelch protein Krh1 and Krh2, Gpg1 was initially considered as the potential Gγ subunit in the putative heterotrimeric G-protein comprising Gpa2 and Krh1/2 as α and β subunits, respectively [
Glucose- (or sucrose) dependent activation of cAMP signaling through the GPCR system is strictly dependent on sugar uptake and phosphorylation [
The glucose transporters have no regulatory function, being only required to maintain a critical level of intracellular glucose to sustain sugar phosphorylation. [
The constitutively active
Hence, glucose-induced cAMP signaling clearly involves two distinct processes: an extracellular glucose-sensing process that is dependent on Gpr1-Gpa2 system and an intracellular glucose-sensing process that is dependent on glucose phosphorylation [
Interestingly, glucose-induced Ras-GTP loading is also dependent on sugar uptake and phosphorylation, while it does not require the presence of a functional GPCR system [
When glucose is available, activation of the cAMP/PKA pathway favors rapid growth and cell proliferation by stimulating the glycolytic flux and by repressing the stress response and the expression of genes required for respiratory metabolism [
Glucose dependent activation of the PKA circuit promotes growth (mass accumulation) and a drastic increase in the cellular biosynthetic capacity by inducing the transcription of genes involved in ribosome biogenesis [
Nutrient availability, growth rate and stress response are intimately interconnected and the switch to fermentative metabolism coincides with downregulation of the stress response [
PKA apparently regulates processes such as growth, glycogen accumulation and stress response by suppressing Msn2/4-mediated gene expression [
In the absence of Msn2/4, PKA can still regulate several stress responsive genes such as
Hsf1 may be regulated by stress-specific differential phosphorylation events, which affect its DNA binding activity [
In contrast to the role of PKA in the regulation of Msn2/4 dependent transcription, which affects all of STRE-containing genes, PKA activity influences only a subset of Hsf1 targets [
PKA dependent phosphorylation negatively regulates the activity of Rim15, a critical kinase for entry into quiescence [
A particularly relevant substrate of PKA is the transcriptional repressor Rgt1 [
Glucose represses the expression of a large number of genes, including those involved in the utilization of alternative carbon sources, gluconeogenesis and respiration through a process known as "glucose repression" [
The level of glucose repression correlates well with the sugar-transport capacity (the diverse hexose carriers do not have a specific regulatory role in the process [
A central component in the signaling pathway for the glucose repression is the Snf1 kinase [
Contrary to AMP kinase complex [
In accordance with its central role in adaptation to glucose depletion and utilization of alternative carbon sources, Snf1 is activated in response to glucose limitation. However, the actual signals triggering its activity have not yet been identified [
In presence of high glucose concentration, the regulatory domain of the
The type 1 protein phosphatase complex, comprising the Glc7 catalytic subunit and the Reg1 regulatory subunit, counteracts the activation of Snf1 mediated by the upstream kinases [
Reg1 expression, localization, and interaction with Glc7 do not appear to be carbon source–modulated, but the activity of the Reg1/Glc7 complex may be regulated post-translationally: Reg1 is phosphorylated in a Snf1 dependent manner in response to glucose deprivation, whereas a rapid dephosphorylation of Reg1 occurs (likely mediated by Glc7) when sugar is added back to the growth medium [
Several lines of evidence suggest that the Snf1 upstream activating-kinases are not regulated by changes in the glucose levels [
The activity of the Snf1 complexes is also regulated through a β-subunit–dependent subcellular localization [
Snf1 regulates the expression of a large number of genes, including those involved in the metabolism of alternative carbon sources, gluconeogenesis, respiration, glucose transport, and meiosis. Early transcriptomic analysis showed that as many as 500 genes are modulated either directly or indirectly through a Snf1-dependent mechanism in response to glucose depletion [
Snf1 affects the transcription of genes required for metabolism of alternative carbon sources (such as sucrose, galactose, and maltose) mainly by modulating the activity of the Mig1 transcription repressor [
Two additional Snf1-regulated repressors are Nrg1 and Nrg2, both containing the Cys2-His2 zinc finger motif. Both Nrg1 and Nrg2 interact with Snf1, although they are not phosphorylated by the kinase. Rather, Snf1 appears to modulate Nrg2 level and is required for Nrg1 function (reviewed in [
The Adr1 transcription factor (containing a Cys2-His2 DNA binding domain), which promotes expression of genes required for ethanol metabolism and β-oxidation of fatty acids [
Cat8 and Sip4 activate the expression of genes required for gluconeogenesis during growth in the absence of glucose by binding carbon source response elements (CSRE) [
Together with Glc7, Snf1 participates in the regulation of the stress-response transcription factor Msn2 [
Finally, glucose availability regulates via Snf1 the phosphorylation state and nuclear accumulation of Gln3, a GATA transcription factor involved in nitrogen starvation which is also a target of the TOR network [
In mammalian and in
A specific interaction of Snf1 with Swi6, the transcription cofactor that forms complexes with DNA-binding proteins Swi4 and Mbp1 to regulate transcription at the G1/S transition, has been detected [
The three glucose sensing pathways are intertwined in a complex regulatory network with multiple feedback and feedforward regulatory loops that serves to fine-tune the cellular response to glucose availability.
Multiple regulatory mechanisms ensure appropriate
In contrast to
The Snf3/Rgt2-Rgt1glucose induction pathway promotes expression of the Mig2 repressor [
Interestingly, two well-known players in the phenomenon of the glucose repression, Mig1 and Mig2, are differentially regulated, despite their largely overlapping functions: Mig1 (which has a prominent role in the repression process) is an effector of Snf1 which responds to intracellular signals generated by glucose metabolism and regulates the subcellular localization of Mig1 [
Besides inhibiting the expression of several components of the Snf3/Rgt2-Rgt1 circuit (
Glucose dependent repression of several genes (
It is presently unknown how Snf1 inactivation in high glucose would promote degradation of Mth1 and Std1. A popular model for proteolytic removal of Mth1 and Std1 includes nuclear export of the corepressor, which must undergo phosphorylation by the membrane-tethered Yck1/2 prior to being ubiquitinated by SCFGrr1 [
Recent evidences have shown that Yck1 and Yck2 casein kinase might respond to glucose signals from both the Rgt2/Snf3 circuit and the Glc7/Reg1 phosphatase complex (involved in the Snf1 pathway) to induce degradation of Mth1 and Std1 with the resultant expression of the hexose transporters and the hexokinase encoded by
As mentioned in Section 4.1.2., Hxk2 is a bifunctional protein: in the cytoplasm it works as a glycolytic enzyme, while in the nucleus it interacts with components repressing expression of several glucose-repressed genes [
Expression of
More than 40% of the genes in yeast genome change their expression levels by more than twofold within minutes following addition of glucose to yeast cells growing on a non-fermentable carbon source [
PKA, Snf1, Snf3/Rgt2-Rgt1 and heme-dependent transcriptional activators are responsible for the whole glucose-induced transcriptional response [
About 25% of the glucose-repressed genes and 10% of the glucose-induced genes respond to sugar addition even in the absence of PKA activity, and this regulation depends on glucose import. Many of the glucose-responsive genes whose induction depend (at least partially) on sugar uptake are involved in cell cycle progression and contain MCB and SCB regulatory motifs (active at the G1/S transition) in their promoter. In contrast, genes which require glucose transport to be repressed are often involved in the oxidative metabolism (enzymes of the TCA cycle and electron transport chain) [
Nutrient availability influences growth rate [
Metabolite concentrations can regulate gene expression, which can in turn regulate metabolic activity. Recent analyses of the metabolomic and transcriptional responses of
Apparently, a yeast cell adjusts its transcriptional program, metabolic machinery and growth rate solely on the basis of its perception of the nutrient status, not on the basis of metabolites actually produced from the available nutrients [
While conventional growth models focus almost exclusively on glucose uptake and metabolism, more recent experiments clearly indicate that yeast growth rate is determined not only by glucose uptake, but by glucose sensing as well [
Glucose dependent activation of the PKA circuit promotes growth rate, mass accumulation and a substantial increase in the cellular biosynthetic capacity. Conversely, inactivation of the PKA signaling pathway causes first cycle arrest at START, a regulatory area in the G1 phase of the cell cycle, followed by entry into stationary phase (G0) [
In addition to the cAMP/PKA signaling cascade, the other major nutrient-responsive, growth-controlling pathway in yeast is the TOR network [
TORC1 activity responds to the nutritional status, primarily the quality of the nitrogen source, and to a wide variety of stress conditions, apparently relaying amino acid concentrations, glucose, and perhaps other nutrient signals to the cellular machinery [
Inhibition of TORC1 by rapamycin (a macrolide drug that in complex with the prolyl-isomerase FKBP12 binds to TOR suppressing its interaction with target substrates) mimics nutrient starvation and causes G1 arrest, inhibition of protein synthesis, glycogen accumulation, induction of autophagy and entry into quiescence [
Expression of the genes encoding the numerous constituents of ribosomes requires transcription by all three classes of nuclear RNA polymerase: TOR controls other aspects of ribosome biogenesis, such as the Pol I- and Pol III-dependent transcription of the rDNA and tRNA genes via phosphorylation of dedicated transcription factors [
"Core growth related genes" (encoding ribosomal proteins and key metabolic enzymes) and stress related genes appear to be regulated independently by the two primary nutrients: carbon and nitrogen sources. Carbon source regulates the expression of these genes through the PKA pathway, whereas nitrogen source impinges on the expression of growth and stress related genes through the TORC1 pathway, which has been shown to directly regulate the activity of Sch9 [
However, the exact relationship between the TOR and PKA networks is still controversial. As an alternative model, it has been proposed that TOR may act upstream of Ras to regulate PKA activity [
Notably, the subcellular localization of the zinc-finger transcription factor Sfp1, the master regulator of Ribi and RP genes, is regulated by both the cAMP/PKA and TOR network in response to nutritional and stress inputs. In actively growing cells, Sfp1 is found inside the nucleus, but it rapidly translocates into the cytoplasm in response to carbon and nitrogen starvation, oxidative stress, as well as inactivation of TOR signaling [
An additional transcription factor that regulates RP and Ribi genes expression in response to TOR and PKA signaling is the forkhead-like protein Fhl1, together with its co-regulators Ifh1 and Crf1 [
Many diverse environmental stresses [including heat shock, osmotic stress, oxidative stress and DNA damage) that activate Msn2/4 through decreased PKA or TOR signaling induce at least a transient arrest of cell cycle progression: Xbp1, a transcriptional repressor with homology to Swi4 and Mbp1, is induced by stress and glucose starvation and may contribute to repress the transcription of the G1 cyclins-encoding genes, thus causing a transient cell cycle delay under stress conditions [
For free living microorganism like the budding yeast
To maintain cell mass homeostasis, cell proliferation requires a precise coordination between growth and cell division [
A molecular mechanism for the sizer mechanism has been proposed [
A further insight derived from our model is that the setting of Ps is recognized as an emergent property of the entire G1 to S network [
The cAMP pathway is involved in the control of cell cycle progression [
Mutant cells with reduced cAMP signaling generally exhibit a consistent decrease in cell size. A
In contrast, hyper-activation of the cAMP pathway results in dramatically large cells.
It is becoming increasingly clear that in yeast the signaling roles of glucose, and possibly of other nutrients as well, has equal dignity to its metabolic role, as indicated by the fact that 90% of glucose effects can be recapitulated by activation of the PKA pathway [
As knowledge of the complete interactions between nutrient sensing, utilization and metabolism on one side and the molecular mechanism of cell growth and cell cycle increases, it will be possible to define a multi-level understanding of yeast growth and division. Through the emerging tools of modular systems biology [
Work in the authors' laboratories has been supported by grant from MIUR to L.A., M.V. and P.C. and EU FP7 (Unicellsys) to L.A. and M.V.; S.B. was supprted by a Uncellsys fellowship.
Growth phases of
Structure of the Gpr1 Glucose Receptor and of the Snf3/Rgt2 Glucose Sensors. (a) The two-dimensional transmembrane topology of the Rgt2p and Snf3p glucose sensors, based on the model of the mammalian Glut1 glucose transporters. The predicted transmembrane domains are numbered I to XII. Aminoacidic substitutions which alter glucose signaling are depicted as coloured dots (see main text for details). Yellow box indicates a repeated sequence of 25 amino acids in the carboxyl-terminal tail of both Rgt2p and Snf3. A second copy (yellow/green shaded box) is also present in the Snf3 carboxy-terminus. (b) The putative structure of Gpr1 model is based on the similarity with GPCRs found in higher eukaryotes [
A simplified view of the glucose sensing mechanisms in
Snf1 is involved in control of MBF G1/S specific transcription factor. The left panel shows a simplified view of the yeast cell cycle showing some of its morphological and biochemical markers. The role of G1/S specific transcription is highlighted. The right panel shows known and putative interactions of Snf1 with proteins at MBF-dependent promoters. Not all proteins known to be bound at MBF-dependent promoters are shown. The Swi6 subunit of MBF transcription factor recruits the


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|Home > Features > Issues > Iraq > Article
With Baghdad deemed safe enough for a visit by the commander of the US-led forces that overthrew Saddam Hussein, US President George W Bush today urged an end to UN economic sanctions on Iraq.
"Now that Iraq is liberated, the United Nations should lift sanctions on that country," Bush said in a speech in St Louis, Missouri. The restrictive sanctions were imposed after the once-wealthy oil-producing country's 1990 invasion of Kuwait.
The White House said the United States would propose a UN resolution to end the sanctions "in the near future" and Washington's UN ambassador John Negroponte said Washington envisioned a "step-by-step procedure".
General Tommy Franks, who directed the war in Iraq, flew in to Baghdad airport, its runways still pockmarked with craters from US bombs, met with troops and military commanders and gave Bush a progress report via videoconference from one of Saddam's abandoned palaces.
"I wanted to get our commanders together in Baghdad because that's been, of course, the centre of gravity for this regime while it stood. And as we all recognise it stands no longer," Franks told reporters.
Although relatively calm, there were incidents of violence and looting in Baghdad and a desperate shortage of electricity, water and medical care in the heavily bombed capital.
Franks said water and power were being restored and hospitals were going back to work after days of anarchy. "I actually believe it will be better seven days from now, quite a bit than it is today," he said.
Ahmad Chalabi, the pro-American leader of the Iraqi National Congress and a favourite with the Pentagon, became the first major exile politician to return to Baghdad since Saddam's fall, an adviser said.
Zaab Sethna, the aide, said Chalabi would would meet community and religious leaders and coordinate his activities with Jay Garner, the retired American general overseeing the effort to rebuild Iraq.
"His first plan is to see his old home and then start building democracy in Iraq," said Sethna, who travelled with Chalabi to Baghdad.
US officials announced first steps to put Iraq's civil service back to work. They said the US administration that will rule the country for the time being would give Iraqi civil servants a $US20 ($A32) per head emergency payment within days.
"Our number one goal is to try to let economic activity begin to happen as quickly as possible," said one official.
The US military also said it hoped to get Iraqi oil fields pumping at two thirds of pre-war levels within eight weeks.
American Marines launched spot raids around Baghdad in search of people linked to Saddam, who has vanished along with his two sons, Uday and Qusay, and most of his ruling elite.
They searched several homes in the city, including that of a scientist wanted for working on weapons of mass destruction. It was not clear whether the home searched was that of Suda Salih Mahdi Ammash, known by US intelligence as "Mrs Anthrax", or Rihab Taha, nicknamed "Dr Germ".
Washington believes both women were top figures in Iraq's chemical and biological weapons programs. "Now that the regime is broken we are pursuing individuals in order to completely remove the potential of the regime ever returning," said Brigadier General Vincent Brooks at US war headquarters in Qatar.
No weapons of mass destruction, the main justification for the US-led military campaign, have been found and only two of the 55 people on a US "most wanted" list have been caught.
At the United Nations, Syria circulated a draft resolution in the Security Council to help transform the Middle East into a "zone free of weapons of mass destruction".
Apparently responding to US accusations that it has given sanctuary to members of Saddam's government and that it has developed chemical weapons, Syria said it would welcome initiatives to rid the Middle East of such weapons "in particular nuclear weapons".
The Syrian proposal appeared to have little short-term chance of acceptance as it primarily targets Israel, which is widely assumed to have nuclear weapons.
Nearly four weeks after the US-led invasion was launched, clashes between Iraqis and US troops were sporadic.
In the northern town of Mosul, three people were killed and several wounded when American soldiers opened fire on them. The incident came a day after seven Iraqis were killed by US troops as they tried to stop a crowd from storming a government complex.
In Athens, European Union (EU) leaders said they wanted to work together and with the United States to rebuild Iraq.
The European leaders are trying to come up with a way, acceptable to Washington, that would give the United Nations and the EU a role in rebuilding Iraq, shattered after the war fought by American and British forces.
In Washington, the White House hailed the capture in Baghdad on Monday of Abu Abbas, former leader of the Palestine Liberation Front and mastermind of the 1985 hijacking of the Italian cruise ship Achille Lauro in the Mediterranean, as proof of a link between Saddam and terrorism.
"When we came into this the Secretary of Defence (Donald Rumsfeld) said one big concern was the nexus between this regime and terrorism," said US military spokesman Captain Frank Thorpe. "This proves the nexus was there."
The Palestinian Authority demanded his release, but Italy said it would seek his extradition.
Abbas, now in his mid-50s, renounced violence years ago and Israel has allowed him to travel to Gaza, declaring him immune from prosecution over the hijacking under a Middle East deal. Washington dropped a warrant for his arrest several years ago.
- Reuters
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Philippine president's funding plan declared unconstitutional
Supreme Court ruling may lead to Aquino's impeachment, say critics
Demonstrators march in Manila on Monday to express anger over alleged government funding scandals (picture: Vincent Go)
July 1, 2014
The Philippines Supreme Court on Tuesday declared a government spending mechanism known as the Disbursement Acceleration Program (DAP) "unconstitutional".
The mechanism, which was established by president Benigno Aquino in 2011, aimed to provide government funds in the form of "fast-track disbursements in light of the global slowdown and the onslaught of recent calamities".
The Supreme Court's decision states that certain "acts and practices" performed under the auspices of the DAP are in violation of the 1987 constitution.
Voting unanimously, the justices ruled that the executive branch of the government overstepped its powers.
Their ruling indicated that the government's Department of Budget and Management allowed funds to be disbursed without correct authorization.
Critics of Aquino say the court decision could form the basis for his removal from office.
Representative Terry Ridon of the Youth Party said he will be "readying all necessary charges against officials involved in the implementation".
He added that the Supreme Court's ruling is "solid ground" for proving culpable violation of the constitution and betrayal of public trust, both of which are impeachable offenses.
Under the 1987 constitution, a vote of one third of the House of Representatives is needed to impeach the president.
"It will greatly bolster the case against President Aquino," said Ridon, adding that it is "a daunting task, but we are prepared to fight."
Activists called for Aquino's immediate resignation in light of the court decision.
"The president and his men clearly violated the constitution and facilitated corruption in government," said Vencer Crisostomo, national chairman of the group Anakbayan.
He added that calls for the president's removal "via impeachment or via a people's uprising" is growing and is increasingly justified.
The DAP came under fire last year after several senators complained that funds had been used as "incentives" for legislators who supported the 2012 impeachment of Renato Corona, former chief justice and a political foe of Aquino.
Government critics have maintained that since its inception the DAP is effectively illegal and no different from the notorious Priority Development Assistance Fund, commonly known as the 'pork barrel'.
Three senators, Juan Ponce-Enrile, Ramon "Bong" Revilla Jr and Jose "Jinggoy" Estrada, who were linked to the 'pork barrel' scandal, were arrested last week on a charge of plunder, the most serious of all corruption charges.
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Sarah Marshall
Genetically modified organisms (GMOs) have received increased media attention over the last year due to controversial bills introduced in the US to label them as well as conflicting views by countries in the European Union as to their safety.
The most widely produced genetically modified crops are corn (maize) and soy, which is why these foods have become prevalent in the majority of processed foods. The alluring claim regarding GMOs is that they produce higher crop yields with fewer pesticides and less water, yet this argument has been widely disputed among the scientific community. Health effects are another major disputed factor, with research being conducted, but often for short time periods, and funded by the biotech companies themselves, posing a grave conflict of interest.
Strong campaigns against labelling GMOs have been launched by biotechnical (Monsanto, Dow Chemical, DuPont) and food companies (Kraft, Nestle, PepsiCo) in the US in order to protect their reputations in the market. The public will likely not respond well to finding out that 80% of packaged food in the typical American grocery store includes genetically modified organisms, even though the same companies trying to stop labelling deem the technology and subsequent food safe for consumption. The public has been consuming GM foods for decades, but major health concerns linked to diet have also come about in that short time frame.
Vermont's new "no-strings-attached" bill requires labelling of GM foods that are offered for retail sale by July 2016. A few other states such as Maine and Connecticut have passed similar bills, but they would only go into effect once other states passed laws requiring the same, in order to streamline the process. Regardless, there is a federal bill being drafted to trump any requirements for labelling of the foods. The so-called "Safe and Accurate Food Labelling Act" would put food labelling into the hands of the FDA (Food and Drug Administration). This would prevent states from being able to pass their own labelling requirements.
The EU has begun taking a laxer approach on the technology, allowing GMOs to permeate more of its tightly regulated food system, but setting clear guidelines in order for farmers and consumers to make informed choices regarding the use of GM technology. Still, many countries have opted out of allowing any GMO cultivation, including Greece, Germany, and Austria.
Earlier this month, France banned the cultivation of any strain of genetically modified maize, even those approved at the EU level in the future. According to Reuters, "Longstanding differences between EU countries resurfaced in February when they failed to agree on whether or not to approve the GMO maize variety Pioneer 1507, leaving the way open to the EU Commission to clear it for cultivation."
Meanwhile, Spain has become the EU's largest producer of GM crops. The country relies heavily on EU farm subsidies and fears WTO backlash if they do not allow the technology. According to Our World, "The difference between the GM maize cultivation rates of France and Spain stems, on the one hand, from weak mobilization of social organizations and insufficient public debate in Spain and, on the other, from the Spanish Government's support of GM companies." Portugal, too, has been a long time advocate for GM technology, planting mostly GM corn varieties.
It would seem that the world is at least getting a bit louder on the issue of genetically modified food crops, even if it is for conflicting reasons. There is no telling what the world's food system will look like in fifty years, but GMOs are here, and likely to stay. Awareness is key to starting the dialogue on such controversial issues. The EU, though more open to GM technology these days, is likely not going to relinquish its reputation in employing the precautionary principle. Though the US will likely hash out this labelling debate for months, if not years to come, they can still count on a strong base of grassroots activists ready to inform the public about food safety issues. It may take time and patience, but the people will fight for their food; it is our fuel for life.
Sarah Marshall, B.S. Environmental Policy


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I received a 100 grain, 2 blade, 1 1/4 Tuffarrowhead from Blackwater Products.
First thoughts. DANG!!! They are THICK! Package indicates they are .051 heat treated stainless. They should be tougher than nails!
I had one concern with the heads while I looked at pics of them on their website. There is a "notch" that the arrow has to fit into between the blades. I was concerned that my oversized Gold Tip 22Seires wouldn't fit between the notches.
As was concerned they would NOT fit on the oversized shafts of the GT22 series arrows.
But NEVER FEAR!! They fist standard sized shafts JUST FINE This is the Tuffarrowhead on my Vicorty VForce V1 shafts. NO PROBLEM.
I haven't gotten to shoot them yet, and don't know when I will be able to. I have to do labor tomorrow........ it is Labor Day and that's what my wife thinks its for.
I don't forsee any flight or durability issue with this head though. Looks solid as a rock! The "issue" with the fat shafts won't be anything to worry about with 95% of the hunting public. Most use standard or slim shafts for hunting.
Another word of caution. They are considered "barbed" and many states won't allow their uses. Read up on your regs first! I have to do that myself. Our regs in WV used to have the no barb requirement but I haven't noticed it for a few years. Just make sure before you take the afield that they are legal in your state.
WOW!!!! That arrow looks beat all to heck! I just looked it over and the pic is making it look really bad. Cant see anything wrong with the arrow.


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The hawk suggested: "There is only one way you can save the dove. Give me part of your own flesh equal in weight to that of the dove."
Shibi said: "How happy I am to hear you say that! Here, take this."
With this, Shibi cut a part of his flesh from his body, and placed it in one of the pans of a balance and put the dove in the other pan. But it was less than the weight of the dove. So the king cut some more of his flesh and put it in the balance. It made no difference. More and more of Shibi's flesh was thrown into the balance. But the balance was still tipped on the side of the dove. As a final measure, the king threw his own body into the scale against that of the dove. Only then did the two weights seem equal.
Then Shibi said to the hawk: "Now you can eat me and let the dove go."
Then the birds revealed their real forms as Indra and Agni.
They said: "Shibi, we came to test your devotion to your dharma. We are fully satisfied that nothing will make you forsake your dharma. We bless you!"
The Gods then returned to heaven.
Shibi ruled the country for a long time. After death he went to heaven. His name is now the very symbol of self-sacrifice.


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Gut-and-Amend Takes Counties Out of the Action
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Friday, August 16, 2013
The CSAC Bulletin
Gut-and-Amend Takes Counties Out of the Action
It is that time of year in Sacramento. Four weeks are left in the legislative session, and that means it's time for "gut-and-amend bills" - entire contents of bills are stripped out of legislation and replaced with new content that often has nothing to do with the original language and usually engenders controversy. One such gut-and-amend, if passed, would silence the voice of local governments on vital statewide issues.
Senate Bill 594, by Senator Jerry Hill, a gut-and-amend bill about a week old, would place significant new restrictions on nonprofit organizations that receive public funds and participate in campaign activities. It broadly expands definitions of public resources, expenditures, and contributions in a manner
that would effectively preclude CSAC and similar organizations from participating, financially or otherwise, in ballot measure campaigns.
Because county supervisors serve as our Officers, Executive Committee members, and Board of Directors members, their participation in CSAC is also caught up in these restrictions.
So why is CSAC being targeted in this bill? Because the proponents are worried that CSAC and other agencies might decide to expend non-public funds to advocate on behalf of local government! CSAC uses great discretion before we jump into political waters, but when we do, it's important.
For example, CSAC advocated on behalf of Proposition 1A, protecting counties from property tax raids and unfunded state mandates – a huge win and a protection that some in state government would love to roll back. CSAC also fought for pension reform and won. That didn't set well with some unions who are now proponents of this bill. We also recently supported Proposition 30, securing funding for schools and public safety, but that was a bitter pill for the other main proponent of the bill – the Howard Jarvis Taxpayers Association.
SB 594 would stifle local government's voice. That is why we are joined in opposition by the California State Sheriffs' Association, California District Attorneys Association, League of California Cities, California Special Districts Association, and many more similarly situated associations. All would be silenced by this bill.
Proponents of the bill have asserted that CSAC and organizations like ours are inappropriately expending public funds for political campaigns. Nothing could be further from the truth. CSAC receives funds from both public and private sources to conduct its business. We receive about 37 percent of our budget from dues and the remainder comes from a variety of sources, including fees for services, rents, and the like – funds that our organization receives as a result of providing goods and services. These funds are accounted for separately, considered non-public, and available for expenditure on ballot measure campaigns should the CSAC's Board of Directors so decide.
CSAC has in fact scrupulously complied with all existing state and federal tax and campaign laws and consistently discloses its campaign contributions just as other compliant nonprofit organizations do. In fact, in 2009, the Fair Political Practices Commission (FPPC) investigated complaints against CSAC and other local agency associations about our use of funds in campaigns
and found no evidence that CSAC and those associations had violated the Political Reform Act
We reject the assertion that we have evaded the law when it comes to our involvement in ballot measure campaigns. And, frankly, it is offensive that this bill is being pushed forward at the last days of the legislative session under false assumptions that only serve to meet the political needs of a chosen few.
SB 594 was heard this week by the Assembly Elections and Redistricting Committee and Assembly Judiciary Committee where it received no "no" votes. It now moves to the Assembly Appropriations Committee for hearing.
County Supervisors should contact their Senators and Assembly Members immediately and urge them to vote "NO" on SB 594.
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Dr. Michael Trotter
is a detail-oriented, compassionate urologist treating patients in the
Austin and greater Central Texas area. He established Midtown Urology Associates in 2005. He and his friendly staff create a personalized and professional family atmosphere for patients.
For faster service, Access Our patient forms online!
Fill-out new patient forms before your appointment: Click Here to View Forms
Welcome to Midtown Urology Associates
At Midtown Urology Associates we provide the highest quality of patient care in a warm, compassionate, private practice office environment. We combine the right mix of personal care with state-of-the-art techniques and technology to meet all of your urological needs.
Dr. Michael Trotter
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Austin, Texas 78705 View Map
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NTS Motorsports has announced that Italian driver Max Papis will run the team's #14 entry in the upcoming Chevrolet Silverado 250 NASCAR Camping World Truck Series race at Canadian Tire Motorsport Park on September 1st.
Papis, an accomplished road racer who won the Rolex Sports Car Series Championship in 2004, will help the team run their first career road race. Papis will join veteran teammate Ron Hornaday Jr and youngster Brennan Newberry at NTS Motorsports for the inaugural event.
Papis has made 44 career NASCAR Camping World Truck Series starts in his career with four top ten finishes. Papis also has 35 career NASCAR Sprint Cup Series starts, with his only top ten finish coming at Watkins Glen in August 2009 where he finished eighth running a Toyota for Germain Racing.
Sports Clips haircuts will support the effort for Papis and NTS Motorsports.Tags: Germain Racing, Max Papis, Motorsports, NASCAR, NASCAR Camping World Truck Series, NTS Motorsports