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This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
The introduction of the so-called "targeted therapies", particularly those drugs that inhibit the activity of tyrosine kinases, has represented a remarkable progress in the treatment of cancer. Although these drugs improve survival rates in cancer, significant cardiotoxicity, manifesting as left vertricular dysfunction and/or heart failure, has emerged. The ErbB receptor tyrosine kinases are being pursued as therapeutic targets because of their important roles in normal physiology and in cancer. Besides the fact that the ErbB receptors are indispensable during development and in normal adult physiology, epidermal growth factor (EGFR) and ErbB2 in particular have been implicated in the development of many human cancers. This review focuses on the rationale for targeting members of ErbB receptor family and numerous agents that are in use for inhibiting the pathway. We summarize the current knowledge on the physiological role of ErbB signaling in the ventricle and on structural aspects of ErbB receptor activation in cancer and cardiac cells. We examine the underlying mechanisms that result in on-target or off-target cardiotoxicities of ErbB inhibitors, which can influence the design of future anticancer therapies.
Cancer therapy has made remarkable progress with the development of "targeted therapeutics". Whereas anthracyclines or radiotherapy are directed at all rapidly dividing cells, these therapies halt cancer cell proliferation and metastases with specific cytotoxicity. This targeted approach, mainly via inhibition of tyrosine kinase activity, has been proved to significantly reduce cancer progression and mortality (including gliomas [
The ErbB/HER family of receptor tyrosine kinases consists of four different proteins called EGFR/ErbB1/HER1, ErbB2/Neu/HER2, ErbB3/HER3, and ErbB4/HER4. Under normal physiological conditions, the ErbB receptors play crucial roles in propagating signals regulating cell proliferation, differentiation, motility and apoptosis [
It is essential to emphasize that not the level of expression, but rather the function of certain tyrosine kinases in the cardiomyocyte correlate with the toxicity induced by their corresponding inhibitors. In addition, rates of cardiotoxicity associated with TKIs are generally underestimated. The latter has several reasons. First, clinical trials have not included predefined cardiac endpoints. The identification of cardiotoxicity has, as a consequence, largely been based on medical history and physical examination [
The identification of the cardiotoxic mechanisms of ErbB-antagonists could help to guide future drug development. It could influence the development of new anticancer therapies in an attempt to achieve an effective treatment of the cancer while minimizing cardiotoxicity.
This review focuses on the rationale for targeting members of ErbB receptor family, in particular ErbB1 and ErbB2. We will review the biology of ErbB signaling in cancer and cardiac cells, the emerging opportunities to target this system with therapeutics and we will summarize what is known of the working mechanisms of currently FDA appoved ErbB targeted drugs. We will focus on the underling mechanisms of these targeted therapeutics that lead to cardiotoxicity and therefore discuss the two types of toxicity ("on- and off-target" toxicity), eludicating these mechanisms.
Subclass I of the receptor tyrosine kinase (RTK) superfamily consists of the ErbB receptors and comprises four members: ErbB1 (also called epidermal growth factor receptor (EGFR)), ErbB2, ErbB3 and ErbB4. All members have an extracellular ligand-binding region, a single membrane-spanning region and a cytoplasmic tyrosine-kinase-containing domain. The ErbB receptors are expressed in various tissues of epithelial, mesenchymal and neuronal origin. Under normal physiological conditions, activation of the ErbB receptors is controlled by the spatial and temporal expression of their ligands, which are members of the EGF family of growth factors [
The EGF family of ligands can be divided into three groups: the first includes EGF, transforming growth factor-α and amphiregulin, which bind specifically to EGFR/ErbB1; and the second includes betacellulin, heparin-binding EGF and epiregulin, which show dual specificity, binding both EGFR/ErbB1 and ErbB4. The third group is composed of the neuregulins (NRGs) and forms two subgroups based on their capacity to bind ErbB3 and ErbB4 (NRG-1 and NRG-2) or only ErbB4 (NRG-3 and NRG-4) (
The importance of ErbB receptors during development and in normal adult physiology is evident from analyses of genetically modified mice. Studies in mutant mice revealed that gene deletion of ErbB2 [
In many different cancer cell types, the ErbB pathway becomes hyperactivated by a range of mechanisms, including overproduction of ligands (e.g., TGF-α and NRG-1), overproduction of receptors, or constitutive activation of receptors. Both overexpression and structural alterations of EGFR/ErbB1 are frequent in human malignancies. Furthermore, in many tumours EGF-related growth factors are produced either by the tumour cells themselves or are available from surrounding stromal cells, leading to constitutive EGFR activation [
Of the four members of the family, ErbB2 is the most closely associated with carcinogenesis.
The role of ErbB4 in oncogenic signaling is more controversial. Some studies have observed lower expression of ErbB4 in breast and prostate tumours relative to normal tissues, and an association with a relatively differentiated histological phenotype [
Due to the central role of the ErbB system in the development of carcinomas, selective inhibition of aberrant tyrosine kinase activity has become an exciting focus of anticancer therapy. Most effort have concentrated on ErbB1 and ErbB2 owing to their increased expression in certain tumour cells relative to normal cells.
Two important types of ErbB inhibitors are in clinical use: humanized antibodies (mAbs) directed against the extracellular domain of EGFR or ErbB2 and small-molecule tyrosine-kinase inhibitors (TKIs) that compete with ATP in the tyrosine-kinase domain of the receptor. Therapeutic monoclonal antibodies (mAbs) bind to the ectodomain of the RTK with high specificity and thereby inhibits its downstream signaling by triggering receptor internalization and hindering ligand–receptor interaction. Unlike small-molecule inhibitors, mAbs also activate Fc-receptor-dependent phagocytosis or cytolysis by immune-effector cells such as neutrophils, macrophages and natural killer (NK) cells by inducing complement-dependent cytotoxicity (CDC) or antibody-dependent cellular cytotoxicity (ADCC) [
The goal of targeted therapy is a high efficacy with minimal side effects. Targeted therapies have been proven to significantly reduce cancer progression and mortality, but unfortunately, a major down-side effect involving the heart emerged in clinical trials [
The two types of toxicity will be explained to eludicate the underlying molecular mechanisms of TKI-derived cardiotoxicity. The first is "on-target" toxicity, wherein the tyrosine kinase target regulating cancer cell survival and/or proliferation also serves an import role in normale cardiomyocyte survival. Thus, inhibition leads to adverse consequences in the heart. Second, "off-target" occurs when a TKI leads to toxicity via inhibition of a kinase or pathway not intended to be a target of the drug. We will summarize examples of on-target toxicity of ErbB inhibitors [
EGFR is overexpressed in several cancers, including colon, breast and brain, and diverse drugs targeting ErbB1 have been developed. Anti-ErbB1 mAbs and TKIs target distinct domains of EGFR, the extracellular ligand-binding domain and intracellular tyrosine kinase domain of the receptor, respectively. Cetuximab (also known as C225; Erbitux®) is a chimeric IgG1-isotype mAb that binds to ErbB1 with high affinity and abrogates ligand-induced ErbB1 phosporylation [
The adverse effects associated with ErbB1 inhibitors are mild. The most common, is skin rash resulting from the effects of EGR inhibition, possible due to the expression of EGFRs in the epidermis. Another common adverse effect in patients treated with TKI, but not in patients treated with mAbs, is diarrhoea [
Experimental and clinical data demonstrate several mechanisms of action of trastuzumab [
ErbB2 antagonists prolong survival in cancer, but also interfere with homeostatic processes in the heart. ErbB2 is the preferred coreceptor for ErbB4, which is activated by NRG-1. This epidermal growth factor (EGF)-like growth factor is released from endothelial cells in the endocardium and in the myocardial microcirculation, hence contributing to intercellular crosstalk in the ventricle. After the observation that gene deletion of NRG-1 or ErbB receptors resulted in cardiac malformation or dilated cardiomyopathy, cardiac cell and tissue responses to NRG-1 have been studied. NRG-1 was observed to increase the cardiomyocyte resistance to apoptotic cell death [
The cardiac side effects of trastuzumab, manifesting as a decrease in left ventricular ejection fraction (LVEF) or as symptomatic CHF, was noticed in the initial trials. Herein, trastuzumab was administered on top of standard therapy, which consisted of either paclitaxel or doxorubicin and cyclophosphamide. The incidence of cardiotoxicity ranged from 1% to 4% with paclitaxel alone to 11% when trastuzumab was administered on top of paclitaxel. Anthracyclines, such as doxorubicin, are themselves cardiotoxic, but addition of trastuzumab leads to a synergistic increase in incidence of cardiac symptoms from 7% with trastuzumab alone, to 27% when anthracyclines were administered concurrently [
Surprisingly, unlike trastuzumab, clinical trials suggest that lapatinib has minimal cardiac toxicity. Two published phase I trials involving 67 and 81 patients respectively with advanced refractory solid malignancies reported minimal cardiotoxicity [
ErbB3 appears to play a central role in oncogenic signaling, where the ErbB2/ErbB3 heterodimer functions as an ongenic unit, the role of ErbB3 being to activate the PI3K/Akt pathway [
The decrease in morbidity and mortality achieved with targeted therapies represents a milestone in cancer treatment. However, a growing number of cancer patients are becoming victims of their doctors' success, experiencing cardiovascular side-effects of anti-cancer treatments, including the induction of heart failure. Risk of cardiotoxicity is underestimated in current clinical trials which generally lack older patients and patients with significant co-morbidities. Furthermore, the risk of adverse events may increase as the novel agents target the growth and survival pathways of the healthy cardiomyocyte (notably the PI3K/Akt pathway and the ERK1/2 cascade). The combined use with each other or the use with other cytotoxic chemotherapeutics is also not beneficial. Our increased understanding of the molecular and structural characteristics of the ErbB family has been essential for the rational development of ErbB-targeted inhibitors. Nevertheless, there are numerous details to be revealed concerning the molecular mechanism underlying anti-ErbB drug-related cardiotoxicity. Considering the role of the oncogenic ErbB2-ErbB3 unit, it will be interesting to determine if activating ErbB3 mutations are uncovered in tumours that have low ErbB2 expression. Another concern will be to investigate the role of inhibiting ErbB4 by multitargeted ErbB-inhibitors determining in this way whether targeting multiple ErbB receptors will lead to unacceptable toxicity. The risk for cardiovascular side effects must be carefully balanced against potential benefits of treatment. For cancers with very poor prognosis, short-term cardiac side effects that reduce quality of life are relevant. Delayed toxicity, on the other hand, fall to a lower priority. In cancers with high likelihood of long-term survival and in the neo-and adjuvant setting, it is very important to consider cardiovascular risks. Anyhow, to make sure that the cured cancer patient does not succumbs treatment's side effects, we need to achieve effective cancer treatment, while minimizing cardiac toxicity.
Improving cardiovascular outcomes in patients undergoing cancer treatment requires appropriate risk assessment, monitoring, and long-term follow-up care. Baseline cardiovascular assessment, before starting cancer treatment, and cardiologic surveillance during and after its completion by the evaluation of LVEF using echocardiography, are essential for detecting cardiotoxicity. However, LVEF measurement is a relatively insensitive tool for detecting subclinical myocardial injury. A new approach, based on the use of cardiac biomarkers and tissue Doppler imaging, has emerged, proving to be a more sensitive and specific tool for the early identification, assessment, and monitoring of drug-induced cardiac injury. Cardiospecific biomarkers, such as serum troponin and brain natriuretic, show high diagnostic efficacy in the early subclinical phase of the disease before the clinical onset of cardiomyopathy. Finally, the oncologist and cardiologist should collaborate to improve disease prognosis and patient overall survival.
ErbB receptor tyrosine kinases and their ligands (
Mechanisms of ErbB signaling and inhibition in tumour cell. Oncogenic signaling incancer cells can be mediated by overexpressed ErbB2, ErbB2 homodimers or ErbB2/ErbB3 heterodimers, and also by ErbB1 homodimers or ErbB1/ErbB2 heterodimers. These events trigger signaling through a complex array of intracellular pathways that initiate and control a range of cellular processes. Out of many signaling event in a network, three key signaling pathways are the Ras-Erk (mitogen-activated protein kinase (MAPK)), the phosphatidylinositol 3-kinase (PI3K)–AKT and the Janus Kinase (JAK-STAT) pathway. The monoclonal antibodies (mAbs) cetuximab, panitumumab, trastuzumab and pertuzumab act extracellulary by blocking ligand binding and/or receptor dimerization. The small molecule tyrosine kinase inhibitors (TKI) gefitinib, erlotinib and lapatinib compete with ATP in the tyrosine-kinase domain of the receptor and block tyrosine kinase activity. Both interrupt downstream signaling. In addition to inhibiting ErbB signaling, mAbs might also mediate anti-tumour effects through antibody-dependent cell-mediated cytotoxicity (ADCC). Inhibition of ErbB2 by trastuzumab impairs all downstream events, in particular reversing BCL2-antagonist of cell death (BAD) inhibition, leading to a decrease in anti-apoptotic Bcl-xL expression. This leads to a destabilization of the mitochrondrial membrane and ATP depletion, cytochroom c release and caspase activation. Only signaling through these three pathways and known subcellular processes are shown here for simplicity.
Mode action of current ErbB2 inhibitors. Trastuzumab, pertuzumab, and lapatinib have a different mode of action on ErbB signaling. Trastuzumab (
Cardiotoxicity of ErbB-targeted therapeutics.
|Other toxicity
|Trastuzumab (Herceptin®)
|Humanized mAb
|ErbB2+ breast cancer
|Infusion reactions, neutropaenia
|Lapatinib (Tykerb®)
|EGFR/ErbB1; ErbB2
|ErbB2+ breast cancer, ovarian cancer, gliomas, NSCLC
|Skin rash, diarrhoea
|Cetuximab (Erbitux®)
|Chimeric mAb
|CRC, squamous cell carcinoma of head/neck
|Skin rash, infusion reactions, interstitial lung disease, hypmagnesaemia
|Panitumumab (Vectibix®)
|Human mAb
|Skin rash
|Gefitinib (Iressa®)
|NSCLC, gliomas
|Skin rash, nausea, diarrhoea, interstitial lung disease
|Erlotinib (Tarceva®)
|NSCLC, pancreatic cancer, gliomas
|Skin rash, nausea, diarrhoea, interstitial lung disease
|Pertuzumab (Omnitarg®)
|Humanized mAb
|Breast, ovarian, prostate cancer, NSCLC
|Skin rash
Rate of cardiotoxicity is only known for trastuzumab. Therefore others represent best guesses. mAb, monoclonal antibody; TKI, tyrosine kinase inhibitor; EGFR, epidermal growth factor receptor; CRC, colorectal cancer; NSCLC, non-small-cell-lung cancer.


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All Bank Of Baroda (bob) branches in Surat District with IFSC Code
Find IFSC Code using the Lists below...
First select your bank, select the state, now select your district and finally select the branch of your bank to find IFSC Code. If you need to change any search list term, please use menu or search.
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Branch wise list of BANK OF BARODA (BOB) in SURAT
Banks List with IFSC Code
List of all Bankss with IFSC Code
Branches in Surat District
Bank Of Baroda has the following branches in Surat district. List as follows, Ambaji Road Branch, Ambheti Dist Surat Gujarat, Amroli Br Surat Gujarat, Anaval Dist Surat Gujarat, Areth Dist Surat Gujarat, Athwalines Branch, Baleshwar Dist Surat Gujarat, Bamroli Road, Bandharpada Dist Surat Gujarat, Barbodhan, Bardoli Branch, Bhatar Road Branch, Bhatgam Gujarat, Bhesan Surat Gujarat, Bhimpore Dist Surat, Bhulkabhavan Branch, Bodhan Br Dist Surat Gujarat, Cfs Branch Surat Gujarat, Chhipwad Branch, City Light Branch, Damka Dist Surat Gujarat, Dihen Dist Surat Gujarat, Dolvan Br Dist Tapi Gujarat, Dumas Br Dist Surat Gujarat, Dumbhal Branch, Fulpada Branch, Ghoddod Road Surat Gujarat, Gothan Gujarat, Gunasvel Gujarat, Hajira Dist Surat, Haldharu Dist Surat Gujarat, Hanjer Chamber Surat Gujarat, Haripura Dist Surat Gujarat, Honey Park Road Gujarat, Ibb Surat Branch, Ichhapore Br Dist Surat Gujarat, Ie Pandesara Branch, Jahangirpura, Jhankhavav Dist Surat Gujarat, Kadodara Surat Gujarat, Kalakava Br Dist Tapi Gujarat, Kamrej Char Rasta, Kanza Dist Surat Gujarat, Karchelia Dist Surat Gujarat, Katargam Surat Gujarat, Kavas Br Dist Surat Gujarat, Khand Bazar Branch, Khatodra Branch, Kim Br Surat Gujarat, Kosamba Dist Surat, Kribhco Branch, Kudsad Guj, Kukarmunda Dist Surat Gujarat, Kundiyana Br Dist Surat Gujarat, Lajpore Dist Surat Gujarat, Lh Road, Limbayat Guj, Madhi Dist Surat, Magdalla Surat, Mahuva Gujarat, Mandarwaja Branch, Mandvi Dist Surat, Manekpore Gujarat, Masma Br Dist Surat Gujarat, Mor Bhagwa Dist Surat Gujarat, Mora Dist Surat, Mosali Dist Surat, Mota Gujarat, Mota Varachh Dist Surat, Nanpura Branch, Navagam Fort Songadh, Navyug Colle Branch, Olpad Dist Surat, Pal, Palanpur Patia, Parle Point Branch, Parsi Sheri Branch, Pasodara, Pinjarat, Piplod Br Surat Gujarat, Piplod Gujarat, Prime Arcade, Puna Kumbharia Surat, Rander Branch, Rayam Br Dist Surat Gujarat, Sachin Br Surat, Sagrampura Branch, Salabatpura Branch, Sarbhon Gujarat, Sarthana, Sayan Dist Surat, Sayedpura Branch, Shahpore Branch, Singpur Gujarat, Sp Pr Bking Branch, Ssi Sachin Br Surat, Sufibaug Branch, Surat Main Surat, Surati Bazar Vyara, Taladpatia Gujarat, Talangpor Br Dist Surat Gujarat, Textile Mkt Branch, Uchhal Dist Surat Gujarat, Udhna Branch, Udhna Magdalla Road Gujarat, Ukai Dist Surat, Umarpada Br Dist Surat Gujarat, Umbhel Br Surat, Un Dist Surat Gujarat, Utran Dist Surat, Vadapada Nesu Naranpur, Vaheval Surat Guj, Valod Dist Tapi, Vanesa Gujarat, Vania Sheri Branch, Vankal Br Dist Surat Gujarat, Vankaner Dist Surat Gujarat, Ved Road Branch Surat, Velda Gujarat, Vesu Bharthana Surat, Vesu Branch Dist Surat, Vihan Br Dist Surat Gujarat, Vip Road Surat, Zampa Bazar Branch. Indian Financial System Code, Magnetic Ink Character Recognition, SWIFT Code, Address and Contact number are listed.
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subset: commoncrawl


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Light and Lemony Fruit Salad/Dessert
Recipe by LAURIE
DD#2 needed a quick, light "something" to take to a picnic an hour after she got home from work. I remembered reading a salad recipe with a package of pudding added so I opened the cupboard and started draining and dumping. She came home with an empty bowl and requested I make more for home. That's a good sign I think! (Cooking time is for refrigeration)
Top Review by SouthernCookinChef
UPDATE: I made this again using off-brand pineapple that had more juice and less pineapple, and it was HORRIBLE. Runny and tasteless. You MUST use Dole pineapple chunks in HEAVY SYRUP and dry the cherries and mandarin orange slices thoroughly or this won't be a good recipe.<br/>Original review: This is heavenly! Everyone LOVED it! The bowl was scraped clean! I will quadruple this recipe next time for a crowd. It is my new favorite fruit salad....DELICIOUS! I used the pineapple chunks in heavy syrup which made a difference, I think.
See Discussion:12 Reviews 1 Tweak
Ingredients Nutrition
- 1 (3 1/2 ounce) package instant lemon pudding
- 1 (10 ounce) bottle maraschino cherries, halved,drained
- 1 (8 ounce) container Cool Whip, thawed
- 1 (21 ounce) can chunk pineapple, do not drain
- 1 (12 ounce) can mandarin oranges, drained
- 2 cups mini marshmallows
Directions See How It's Made
- In serving bowl, dump can of undrained pineapple.
- Pour pudding mix over and mix into juices.
- Set aside for 5 minutes to slightly set.
- Meanwhile drain oranges and cherries, patting dry if necessary.
- Mix into pineapple mixture along with marshmallows.
- Gently fold in cool whip.
- Refrigerate at least 30 minutes.


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Cafe Hollander proves itself a great new Milwaukee icon
Gil's Café was a Downer Avenue icon, known for its outdoor seating, coffee drinks, four-cheese pizza, and an unparalleled chicken Caesar sandwich, not to mention Gil Fest, the restaurant's own Milwaukee festival; so when Gil's closed their doors and made way for Café Hollander, 2608 N. Downer Ave., many Milwaukeeans mourned the end of an era.
Café Hollander, a creation of the Diablos Rojos group, maintained the integrity of the cream city brick building, and threw us a few memory bones in the form of coffee drinks, hearty breakfasts and for our more mature dining audience, a tribute to the Coffee Trader Potato Noshers ($8.50); a french fry meets nachos creation that won the hearts of many locals some 10-plus years ago.
Café Hollander features a split smoking and nonsmoking downstairs dining section, which offers a good selection of Belgian ales, and like the Bay View icons The Palm Tavern and Roman's Pub, offers these specialties in their brand appropriate glasses for that added panache.
Menu items are in a word, eclectic. This restaurant features two direct ends of the spectrum while almost entirely avoiding the middle ground; for example, diners can order baked pretzels ($3.50) or a filet mignon ($24.00); but most items at Hollander lean towards the more expensive side, with a trickle of Dutch influence throughout the menu.
Recent visits brought two entirely different experiences at Cafe Hollander. Sunday brunch brings with it a crowd of young families, college students, and young couples, to sample Belgian waffles, eggs Benedict and bloody marys. The restaurant is child friendly, as are the waffles; large thick Belgian classics ($6) dusted with powdered sugar or with a variety of toppings from fruit ($7-$8), to onions and bacon ($8.50), to Guinness stout ($9.50).
The Hollander brunch special ($9) paired one of these waffles with shaved ham, white cheddar cheese sauce, tomato and a fried egg for a hearty and delicious offering. Tuscan Benedict ($9.50) served with prosciutto, asparagus, and white truffle hollandaise was the only disappointment to an otherwise above par brunch; the dish had sat too long, making it cold and congealing the hollandaise leaving it bitter and inedible.
Weekday dinner at Café Hollander brought with it a crowd of more mature diners, likely stopping for a visit before a show at the Downer Theater or a book reading at the nearby Harry W. Schwartz. With such a diverse menu, we spent a lot of time deciding what to order before settling on several items from acrossed the board. Curried mussels ($10.50) were delightful in a rich curry cream sauce served with a crusty baguette. Belgian burger sliders ($8.50) were overcharred and bitter, and were surprising served with mixed baby greens. A cup of Dutch split pea soup ($3.50) was thick, creamy and delicious, and a bowl would be equally satisfying as a meal.
Café Hollander's lunch and dinner menu features entrees in the $18-$24 range, and sandwiches in the $8-$10 range, and on our most recent visit, we opted for the sandwiches. Blackberry turkey ($9.00) was the enticing combination of turkey breast with blackberry jam, gruyere cheese, and hot giardineira served with a side of the house specialty patat frites (french fries). A Belgian Dip ($9.50) added smoked gouda cheese and ale braised onions to the classic sandwich. Both sandwiches were good, but overwhelmed by their baguettes; the actual slice of baguette was only filled with meat to the half way point, leaving the diner with another half of sandwich that was comprised of cheese, bread and spread. The French fries are crisp and lightly salted, and for 75 cents, you can choose one of their 18 sauces including spicy Thai peanut and curry ketchup.
Café Hollander shines in ways that will easily make it a new Milwaukee icon, and a place where former Gil's fans and new patrons alike can feel comfortable and well served. Service here is exceptional, and the space lends itself well to either dining or just stopping by for a Belgian ale or a glass of wine before a show. Outdoor seating will make this an even greater dining option for both students and Downer avenue area residents for many years to come.
lexor | July 19, 2007 at 10:33 a.m. (report)
having heard a few less than glowing reviews of this place, i was a bit wary of eating there, but i thought it deserved a at least a try...i was wrong - it didn't. being owned by the same folks who run Troc, it comes as no surprise that the establishment is long on style but woefully short on substance. i attempt to order, "i'll have the filet mign....", waiter interrupts, "um, we're out of that, sorry.". me, "ok, then i guess i'll have the wild mushroom pappard...", waiter again interrupts, "i'm afraid we're out of that, too.". i try again, "well, i'll need a minute to look the menu over again, in the meantime, could you bring me a cup of the split pea soup?" guess what? yep, they're out of that as well. at this point i inform the waiter that we'll just finish our mussels and frites plate thingy and leave. the mussels tasted old, the broth pretty much tasted like warm water, no flavor, no seasoning. the frites? soggy, room temperature, not a grain of salt to be found in the whole order. nice mustard aioli: tasted pretty much like, well, straight up mustard. ailoi, by definition, has garlic in it; throw mustard in it if you like, but if i can't taste the garlic, it's just mayo. add this to the long and ever lengthening list of Milwaukee restaurants that will never get another dime from me. to sum up - apparently the kitchen staff know neither how to cook nor how to stock a kitchen - i swear there are only about three chefs in this city who know their ABCs, and that's sad.
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TomSellecksMustache | June 10, 2007 at 7:53 a.m. (report)
Even after reading the slew of negative comments on this place, I decided to meet up with some friends and form my own opinion. We arrived right around 9pm Saturday and were seated immediately. When finally settled at our table for five I quickly noticed the full bar and the wide screen TV in the smoking section. A nice touch. The beer menu offered many options. I have to say the person who said this aspect of the menu was expensive is mistaken. Maybe they were looking for cheap bottled domestic swill, but a Guinness was only $5 and it was not alone at that price. Sure, there are quite a few more pricey selections but there is plenty to choose from at the $5 to $6 range. I had the eggplant panini and it was quite good. My other dining companions had the Proscuito delight, the Mussels in Steamed Ale and another sandwich which I believe was chicken based which everyone loved but I did not catch the name. Our server was prompt and attentive, although once she did forget a beer refill whilst remembering to bring back a new martini to our table. All in all a fine dining experience. Our tab between five people including eight beers and two martinis was approximately $130, including five entrees and one appetizer of fries ($4!). It was a fine evening that everyone enjoyed.
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DavidOtto | March 23, 2007 at 9:24 p.m. (report)
This place has the WORST FOOD and THE WORST SERVICE I have been there three times and have been under whelmed and extremely disappointed every time. I ordered a dish if fries, peanut sauce and mayo, the portions were sickening to say the least, at least 2 cup of mayo was sloped on my plate and the amount of fries made me lose my appetite. I left with out taking a bite. DISGUSTING, HORABLE are the only words for that place.
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yucky. | March 8, 2007 at 5:07 p.m. (report)
Oh, man. The food was terrible. Sandwiches were so hard and greasy we couldn't get past the first bite. Fries were good but too soft and greasy to even campare to real frites. Beer selection is great but so expensive. I wouldn't recommend this place to anyone...was a disappointment.
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jmhummel | March 3, 2007 at 11:17 a.m. (report)
Service here is exceptional?! Unfortunatley, I took my parents here after being fooled by ordering seemingly the only good thing on the menu (Belgian dip) my first visit here. We liked Trocadero, so we figured we'd like this place....I would have to echo the sentiments of not impressed on this one...The only thing worse than sitting at your table being ignored while your food is in plain view congealing under heat lamps in the kitchen is actually getting the food and it tasting...not good...My burger was a charred cold hockey puck, my mom's wild mushroom pizza was incredibly bland (good luck getting water to wash it down with!), and my dad's belgian dip was good as ususal. And note to owners: Belgian fries or 'frjtes' as they are called are supposed to be thin, well-done and crispy, almost like fried potato sticks. Pairing thick-cut soggy french fries with different types of mayo does not make them frjtes! As we were leaving, my dad said, "we should have just gone to Comet"....my thoughts exactly...
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Customer Perceptions
About Customer Perceptions:
Customer Perceptions Ltd., is a leading provider of Mystery Shopping and Consumer Research. Offering our services throughout all of Ireland and the UK.
We work in partnership with retail, wholesale, manufacturing and service sector businesses, large and small, across a diverse range of activities…But all with one thing in common…Professional managers who understand the absolute necessity to see their business through their customer's eyes….
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Latest question:
How do you think the new GigE standards will influence the machine vision industry?
Respond or ask your question now!
Leica Microsystems is pleased to present Leica AF6000, the successor to Leica FW4000. By combining the acquisition features of FW4000 with LAS (Leica Application Suite) software, Leica AF6000 provides the most powerful, easy-to-use, multi-dimensional acquisition system on the market.
Leica AF6000 is a fully integrated system for advanced fluorescence imaging and provides solutions that evolve with changing research requirements. From overlaying multi-channel images to acquiring three dimensional and time lapse data, a wealth of features are included as standard for image documentation, quantification, enhancement and analysis. Designed to completely harmonize the microscope, camera, and application. The Leica AF6000 is compatible with upright and inverted microscopes.
Application modules for advanced acquisition and analysis extend Leica AF6000�s capabilities to provide solutions for a multitude of applications from calcium ratio and FRET analysis to colocalization and motion analyses. Additionally, AF6000 provides a completely integrated interface to Autoquant�s deconvolution algorithms as well as a separate 3D visualization module.
Leica Microsystems, Bannockburn, Ill. www.leica-microsystems.com


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We are excited to announce a 4 week residency at local hot spot Red Square. We'll be playing every Monday in October (except Halloween) from 8-11Pm. There are a bunch of new (and old) songs being prepared for these shows and we plan to bring a few friends along as well.
Check out the show schedule for more information.
This post is tagged Red Square, Residency


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Th' owd chap pools his watch aat an mak's sure o'th' time when they start, an' away they goa like a burd.
I vow she would fain have a burd That bids such a price for an owl.
Send out our supper by the lifeguard, called burd, as he followed his chum into the surf.
These dogs belonged to burd Isbel, and they were her special pets.
You know, observed burd sternly, although these fish out here may be dumb, they are not deaf.
burd Alling had said it was only as wide as "two hoots and a holler."
"I didn't know Miss burd prowled about the garden in a dressing-gown," exclaimed Ingred.
"Come on, Darry," burd drawled, taking a hint from the girls.
You call yourself the son of burd, though you are the son of another man.
Your brother and burd Alling have got back with that yacht, havent they?
poetic word for "woman, lady" in old ballads; later "young lady, maiden;" c.1200, perhaps from Old English byrde "wealthy, well-born." Or a metathesis of bryd "bride." The masculine equivalent was berne.


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About Us:
Our doors are open daily for meditation and prayer.
Services: Eucharist, Sun - 10AM, Wed - Noon | Eve Prayer, Tue - 6:15 PM | Morn Prayer, Thu - 9AM
Services: Eucharist, Sun - 10AM, Wed - Noon | Eve Prayer, Tue - 6:15 PM | Morn Prayer, Thu - 9AM
"Building for the future with thanksgiving and praise."
As Christians we live and minister in our community with a searching, open faith which starts with strong, heartfelt, sacramental Prayer Book worship and leads us forth to committed service in and out of the church. We hope you will feel that welcome
Although small in number, the parish of St. John's plays a vital role in the Randolph community offering opportunities for worship, pastoral care, meeting space, and occasionally even overnight shelter for those stranded without accommodations. St. John's also participates in the Randolph Area Food Shelf, helped to start the Chaplaincy Program at Gifford Medical Center, and played a leading role in the revitalization of downtown Randolph.
An historic church, built in 1869, St. John's is tucked away among the residential houses on quiet Summer Street, one street west of Main Street in Randolph, Vermont.
15 Summer StreetRandolph, VT 05060
United States
See map: Google Maps


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Missing...... Please bump
Posted by + Show Post
Jessica has been missing since Friday morning!!!! Please bump to keep this first!!!!!! We need to bring her home to her family!!!!
Replies (21-30):
by Gold Member on Oct. 8, 2012 at 3:54 PM
Prayers and positive thoughts!
Add your quick reply below:
You must be a member to reply to this post.


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This property has been removed by the agent. It may be let or temporarily removed from the market
Property Description
Letting information:
|Added on Rightmove:
|25 February 2012 (1977 days ago)
Full description
LET SUCCESSFULLY. A modern three bedroomed family house in a popular part of the town, overlooking an open park like area, with integral garage, off-road parking and easily maintained gardens. Unfurnished.
This attractive terraced house provides well presented three bedroomed family accommodation with on the ground floor a good sized lounge, kitchen/breakfast room and a useful utility. A door from the utility leads into the integral single garage, which may offer scope for conversion into further living accommodation, subject to any necessary planning consent and building regulations approval. On the first floor are three bedrooms and a well appointed shower room.
A lawned area is situated to the front of the house with a private drive providing off-road parking and access to the garage. To the rear is a pretty enclosed and terraced garden designed for easy maintenance. In itself the property enjoys a delightful position with a pleasant outlook over an open park like area and views of the town beyond. The property is available for immediate occupancy with no onward chain.
Livarot Walk itself is well placed within easy walking distance of the town centre. The bustling market town of South Molton provides an excellent range of everyday services and amenities including shops, primary and secondary schools, restaurants and banks, together with a supermarket, two health centres, recreational facilities and a cottage hospital. The A361 North Devon link road is within easy driving distance providing quick access to the regional centre of Barnstaple as well as Tiverton and the M5 motorway (Junction 27).
South Molton is surrounded by picturesque North Devon countryside with nearby Exmoor offering beautiful moorland scenery with many foot and bridle paths. The north coast is easily accessible with lovely sandy beaches at Instow, Saunton Sands, Croyde Bay, Putsborough and Woolacombe. Mainline intercity rail links are available at Tiverton Parkway (London Paddington approx. 2 hours) with international airports at Exeter and Bristol.
Energy Performance Certificate (EPC) graphs
Map & Street View
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Disclaimer - Administration fees may apply when renting a property in England, Wales or Northern Ireland. For more details, please contact the agent.
Property reference STM110147. The information displayed about this property comprises a property advertisement. Rightmove.co.uk makes no warranty as to the accuracy or completeness of the advertisement or any linked or associated information, and Rightmove has no control over the content. This property advertisement does not constitute property particulars. The information is provided and maintained by Greenslade Taylor Hunt, South Molton - Lettings .
Please refer to our Renting Guides for further information on how to safely rent a property.
Map data ©OpenStreetMap contributors.


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Total Quality Logistics Releases Enhanced TQL Freight Finder Mobile Application
Cincinnati - Total Quality Logistics (TQL), the first third-party logistics firm to release a freight-finding mobile phone application for the trucking industry, is announcing version 2.0 of its TQL Freight Finder mobile app. The company has added new features and functionality based on feedback from users of the initial application, which was first introduced in February 2011. This updated version will replace the first, and can be downloaded for free from the Apple App Store or Android Marketplace, and used on the iPhone, iPad, iPod touch or Android.
New features include:
- Adjustable Destination Radius
- The flexibility to select different searches by mileage radius for a truck to pick up and drop off shipments
- State to State Search
- See available loads by state without having to specify a city when searching
- Additional Equipment Options Listed
- The ability to search for truck loads for both step decks and vented vans
- Multiple Equipment Selections
- The ability to search loads for multiple types of trucks at the same time
- Canadian Freight Search
- Locate TQL loads into and out of Canada
- Email, Not Just Call a TQL Account Executive
- Email the account executive in charge of managing a load directly by tapping the SmartPhone touch screen
"TQL Freight Finder was extremely well-received from the moment we released it. People were excited about the app, and usage by our carriers has increased as time has passed. Our carriers have provided us with many suggestions on how to improve TQL Freight Finder. In fact, the additional features in this release were based upon feedback from our users," says Eric Olson, TQL Carrier Project Manager. "The new options will make it easier than ever to contact TQL to confirm load details. We're excited to make this tool even more useful for our carriers." TQL Freight Finder allows carriers to search for available loads by mileage radius, equipment type, load date, and destination city/state. The application also provides users with the capability to search for available loads according to their SmartPhone GPS Locator's current location. Search results are returned based on entered criteria and include load details for each available load. View a PDF with more information on TQL Freight Finder features here: www.tql.com/FreightFinderVersion2.
About Total Quality Logistics
Total Quality Logistics is the nation's fourth largest freight brokerage firm with offices nationwide, including: Ohio, Illinois, Colorado, South Carolina, North Carolina, Florida, Indiana, and Kentucky. For the past 14 years, the company has arranged full truckload transportation for thousands of clients nationwide and has built a reputation for its integrity, reliability and unmatched customer service standards. TQL strives to be the most trusted and reliable freight brokerage firm in the logistics industry and has been consistently recognized for this commitment. TQL was recently named a "Top Workplace" in Cincinnati and has earned many accolades both nationally and locally for its outstanding business practices and performance. To learn more about Total Quality Logistics and its superior freight brokerage service, visit www.tql.com


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The weather has been crazy lately: a few days ago I was walking around bare-legged, and today I had to put on a jacket and my beanie! Speaking of: I never thought a beanie would look good on me, but I tried this one on at the H&M men's department last week and I thought it looked quite good! Now my question is: do you take it off when going inside (hello frizzy and flat hair!) or do you leave it on like the cool kids? :D
Sorry if these pictures are a little blurry, I took then quickly before it started raining again and it was getting dark already. You might remember (hate those old posts!) the background as my private roof terrace, I was too lazy to get outside and walk around to find a good photo spot so the roof it is. My street is a good background too, but there are lots of people passing by so setting up my tripod in the middle of the street wouldn't be such a good idea!
|Whoops! That's what happens if you try to pull up your tights with long nails...
|Wearing H&M dress, shirt & beanie, New Look jacket, Forever21 necklace and Sac d'Anverse sneakers


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J-O-N Photographer
Marie SassinModel Female New Orleans, Louisiana, US
Mayhem # 2097612
About MeI am proud to be from Southern Louisiana. I believe there is no culture that can even begin to touch Louisiana. I am very outgoing and spontaneous. I enjoy making people laugh, and I am very good at it. I am open to constructive criticism, or any advice that would help me progress as a model.
-I require an escort to attend every shoot with any new photographer.
Contact me on here, or my email - firstname.lastname@example.com
*I have not had a recent photoshoot in a while. My last photoshoots, I had NO tattoos. I have quite a few now, and plan to get more in the future. Pin up modeling or anything related to tattoos are what I'd be best for. Just a heads up!
Have you worked with Marie Sassin? Add Credits for Marie Sassin! >>
J-O-N Photographer
Oliver Studio Photographer
photos by nola Photographer
Jeff Rizzo Photography Photographer
Carl Edwards Photographer
Andy Hartmark Photographer
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Kate Moss and Jamie Hince Hose the Press
Tuesday night the British Fashion Awards were held at London's Dorchester Hotel.
Photographers reveled in snapping pics of the mysteriously-injured couple that is Kate Moss and Jamie Hince as they left the shindig.
However, after arriving home, Kate, 34 and Jamie, 39, played a trick on the photographers by spraying them with a hose pipe. Good times!
As for the cuts and scratches on the faces of the supermodel and her Kills guitarist, the Daily Mail reports that the abrasions were caused by a "Christmas decoration accident."
Moss and Hince attended a Christmas tree-lighting ceremony at Stella McCartney's store in London's posh Mayfair district Monday night, and regaled party-goers with the story of their accident.
"He said he was on a ladder and she was waiting at the bottom for him to pass down the boxes of decorations," said a guest. "But he lost his grip on one and heavy decorations landed on their heads."
Well, that story does kind of give new meaning to "deck the halls."


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Darren James
|Darren James
February 25, 1964
Detroit, Michigan, United States
Darren James (born February 25, 1964) is an American former pornographic actor who tested positive for HIV in April 2004.
Discovery of infection and aftermath[edit]
In an attempt to prevent a possible outbreak, an urgent search was initiated for potentially infected performers.[1] The search and subsequent testing were conducted by the Adult Industry Medical Health Care Foundation, where James had received his diagnosis. It was concluded that James had possibly been infected while engaging in unprotected anal sex with Brazilian actress Bianca Biaggi during a scene for the video Split That Booty 2 in Rio de Janeiro.[2][3][4]
It was discovered that three actresses who had worked with James shortly after his return to the United States had also become infected. These were Canadian newcomer Lara Roxx, Mareisa Arroyo and Czech-born Jessica Dee.[5][6][7] Roxx had entered the adult industry only two months before contracting the virus.[8] On learning about the HIV outbreak, she has said, "It totally made me realize how I trusted this system that wasn't to be trusted at all, because it obviously doesn't work," and "I thought porn people were the cleanest people in the world."[8]
Judy Star appeared in several movies where Roxx was also in the cast, and was known to have performed a sex scene with a female actress who had performed a scene with James.[9] Star, however, tested negative for HIV.[10] The ensuing fears of HIV infection (as well as the public scandal and criticism of the industry that followed the outbreak) caused a temporary shutdown of production of adult movies in Southern California.[11]
According to James, his diagnosis and the public disclosure thereof — which was how his family learned of his pornographic career — left him so distraught that he attempted suicide. After his recovery, he sued the Adult Industry Medical Health Care Foundation for publicly disclosing his condition. The lawsuit was settled out of court, with terms remaining confidential. James went on to find employment as a security guard.[12] In 2005, the porn industry shutdown was the subject of the first episode of The Dark Side of Porn, a British documentary series produced for Channel 4.[13]
Darren James has remained very vocal about the incident and about adult filmmakers continuing their habits "as usual". He is a staunch advocate of mandatory use of condoms on porn sets to protect performers from HIV.[14] Canadian documentary filmmaker Mia Donovan[15][16] made a 2011 documentary film Inside Lara Roxx, a result of following her life for 5 years with candid interviews and documentation, in addition to showing footage from Darren James in the documentary.
- ^ Nick Madigan (2004-05-10). "Voice of Health in a Pornographic World". The New York Times. Retrieved 2007-02-26.
- ^ AVN :: Test Results Pending for Two Performers Archived June 18, 2009, at the Wayback Machine.
- ^ Gene Ross (2007-05-27). In Brazil the use of condoms is mandatory in penetration scenes, so actually they were breaking the law. "Lara Roxx Timeline Begs Questions: Darren James got it from Lara Roxx, not the other way around?" Check
|url=value (help). Adult FYI. External link in
- ^ "Pyramid of potential infection". Los Angeles Times. 2004-04-16. Retrieved 2008-03-20.
Time line of potential first and second generation infections
- ^ Nick Madigan (2004-04-30). "New H.I.V. Infection Found in Sex-Film Industry". The New York Times. Retrieved 2008-03-20.
- ^ "AVN - Another First-Gen Woman Diagnosed as HIV-Positive". Retrieved 27 September 2014.
- ^ "AVN - Viral Load Results Indicate James was 'Patient Zero'". Retrieved 27 September 2014.[permanent dead link]
- ^ a b "Lara Roxx: "I thought porn people were the cleanest people in the world."". Adult Video News. 2004-04-17. Retrieved 2009-02-08.
- ^ ""Canadian Trio on the Quarantine List; Doghouse Digital Offers Aid"". Archived from the original on 4 March 2016. Retrieved 27 September 2014.
- ^ "On the Roxx", by Kristian Gravenor, Montreal Mirror, 2004-04-29. Retrieved 2007-09-28.
- ^ Nick Madigan (2004-04-17). "H.I.V. Cases Shut Down Pornography Film Industry". The New York Times. Retrieved 2008-03-20.
- ^ Lin II, Rong-Gong. (2009, June 15). "Porn star recalls nightmare of testing HIV positive", Los Angeles Times
- ^ "The Dark Side of Porn Channel4.com". Retrieved 27 September 2014.
- ^ Rong-Gong Lin II (12 October 2010). "Former porn star Darren James speaks out about latest HIV case". Los Angeles Times. Retrieved 21 May 2012.
- ^ Christine Estima (8 May 2012). "Hot Docs interview: Mia Donovan, director of Inside Lara Roxx". TheGATE.ca. Retrieved 21 May 2012.
- ^ Brian McKechnie (5 May 2012). "Interview: Filmmaker Mia Donovan looks at what's 'Inside Lara Roxx'". Criticize This, Canada. Retrieved 21 May 2012.
External links[edit]
- Darren James on IMDb
- Darren James at the Internet Adult Film Database
- Darren James at the Adult Film Database


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The Perseus Arm is one of many curved "arms" of the Milky Way Galaxy which contains many spatial objects including stars, planets, and nebulae.
Between 2253 and 2260, the Federation starship USS Algol performed an extensive survey of the Perseus Arm. (Ship Recognition Manual, Volume 4: Starships of the Original Series Era)
External linksEdit
- Perseus Arm article at Memory Alpha, the canon Star Trek wiki.
- Perseus Arm article at Memory Beta, the non-canon Star Trek wiki.
- Perseus Arm article at Wikipedia, the free encyclopedia.


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Grandpa gets a puppy after his wife passes away
Click here to follow the Mathew Blades Show on Facebook:
There's nothing sweeter than the idea of growing old with your spouse, but that can also make losing that special person that much more painful. Davy Vanhaesendonck's grandfather lost his wife after 63 years, so Davy decided to get him an adorable puppy. The grandfather's response is honestly a tearjerker. Check out the video below to see for yourself.


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Incorporating the Celtic quatrefoil or "four leaves" design, this shape encircles a delicate knot uniting the symbols for luck and protection. This charm is perfect to delicately dangle on a charm necklace or bracelet. So easy to make and so simple to wear. Download our free Learn to Layer project to learn how.
Made in Israel by JBB International, the finish is hypoallergenic and lead-free.
Sold Individually.


text: FYI. === Participative Web: Shaping Policies for Creativity, Confidence and Convergence in the Digital World Government Conference Center, Ottawa, Canada Jointly Organised by the OECD and Industry Canada 3 October 2007 This site is directly accessible at: www.oecd.org/futureinternet/participativeweb The use of the Internet is characterised by increased participation and interaction of users to communicate and express themselves. The expanding use of the Internets inherent capabilities for creation and exchange is often called the participative web. It is an Internet influenced by new intelligent web services enabling users to contribute to developing, rating, collaborating and distributing Internet content and developing and customising Internet applications, driven by an expanding broadband base and easy-to-use software to create and distribute content. The collective intelligence of Internet users is driving new social and economic applications, with the participative web increasingly important across an expanding range of business, research and innovation and social activities. More open approaches to information creation, exchange and diffusion are being taken up extensively in government, education and other areas. As new models for creation, distribution and use of digital information are enabled by the Internet, new policy challenges for governments are emerging to provide the environment that enables and supports these development and diversity of use. Questions to be addressed in the Foresight Forum include: What does the future hold for the participative web? What are the trends and impacts on knowledge-creation, business, users and governments? What are the implications for enhancing confidence and trust in the Internet? What is the government role in providing the right environment for stimulating Internet innovation and economic growth? This first-ever international policy forum on the participative web will bring together experts from around the world, from policy makers and academics to business executives and a wide range of civil society to address these questions. The presentations and discussions around the themes of Creativity, Confidence and Convergence will contribute to the OECD Ministerial Meeting on The Future of the Internet Economy in Seoul, Korea, 17-18 June 2008. Previous yearly OECD Technology Foresight Forums have dealt with Radio-Frequency Based Identification Technologies (RFID) (2005) and Next Generation Networks (2006). --------------------------------- Boardwalk for $500? In 2007? Ha! Play Monopoly Here and Now (it's updated for today's economy) at Yahoo! Games.


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Kris Delmhorst Releases New LP, Blood Test via Signature Sounds
On May 13, Signature Sounds releases Blood Test, the latest LP from acclaimed singer-songwriter Kris Delmhorst. In celebration, the Wall Street Journal is exclusively premiering the brand new video for the track "92nd St" at http://on.wsj.com/1qzEh1C. The album is currently streaming in its entirety over at MSN Music: http://on-msn.com/QEGHv8. Delmhort is currently touring the U.S. in support of the release-see below for full tour dates.
The release marks Delmhorst's first album of original material since 2008's Shotgun Singer, which Performing Songwriter described as "a tour de force of singing, writing and production that gains in richness with each repetition," and the Boston Herald called "a work of lo-fi beauty, and evidence of an artist taking flight." In between, the versatile performer recorded and released Cars, a covers album of songs by the seminal new wave/proto-punk band of the same name, which PopMatters called a "victory" and noted, "Cars has the potential to bring a brilliant young songwriter to a wider audience."
Co-produced by Delmhorst and fellow songwriter Anders Parker (Varnaline, Gob Iron, New Multitudes), Blood Test was recorded in Brooklyn, NY along with drummer Konrad Meissner (Brandi Carlile, The Silos) and multi-instrumentalist Mark Spencer (Blood Oranges, Lisa Loeb, Laura Cantrell, Son Volt). "I was focused on paring things down to their elements-less flesh, more bone," Delmhorst says. "So it's just the four of us on Blood Test, with very few overdubs, playing the songs and letting the imperfections be part of the story. There's a freshness and spirit of discovery in the tracks that I think shines through and gives them a lot of life." Please see complete track listing below.
As a Brooklyn native who for the past 20 years has called Massachusetts home, recording Blood Test in the middle of her old stomping grounds had a profound effect on Delmhorst. "I was getting coffee at the deli I used to go to in high school, then walking to the studio," she says. "It was a kind of vertigo feeling to be working there, a little dizzying, but also really satisfying; it somehow completed the circle." And while her New York upbringing is on full display on the album (see "92nd St" for an obvious example), so is her current life in the hills of western Massachusetts with husband and fellow songwriter Jeffrey Foucault and their young daughter.


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Second Eleven debutant Scott Newman was stumped having scored 15 runs in Nottinghamshire's rain hit Trophy game against Worcestershire.
With the game reduced to 20 overs, Notts posted 149-4 batting first but Worcestershire only faced 3 overs before a torrential downpour ended play.
Will Jefferson (41 off 25) and Kevin O'Brien (36 off 22) were the most effective Nottinghamshire batsmen but the sides had to settle for a point each.


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Campus Map
Find Your Way Around Campus
Class Schedule
A Complete List of Classes
Many students today are fed up with the cost of higher education. They believe today's universities are overpriced and impersonal. Like our students, we care about high-quality education with a personal touch and all at an affordable price. We will be your coach when times get tough and you'll learn to believe in yourself. Put yourself first and join us at Cañada College. Transform your future today.
The Business Department offers degrees in the following:
- Associates Degrees for Transfer (AD-T) - Business Administration
- Associates of Science (A.S.) - Business Administration
- Associates of Science (A.S.) - Entrepreneurship and Small Business Management
- Certificate of Achievement - Business Administration
- Certificate of Achievement - Entrepreneurship and Small Business Management
AD-T and A.S. degrees are approximately 60 semester credits. Certificates of Achievement are approximately 18 - 21 units each. The majority of our business classes are 3 semester units each. Full-time students take 12 or more units per semester. Students also have the option of attending college part-time depending on their schedule.
We offer a variety of classes during the fall and spring semesters, as well as during summer session. We have traditional day courses, evening courses, online and hybrid courses.
Find a complete list of our current offerings on WebSchedule. Cañada College is in a three-college district along with the College of San Mateo (CSM) off of highway 92 in San Mateo and Skyline College in San Bruno. Students can take classes across the district at any of the three colleges to count towards their degree or certificate. See an academic counselor for more information.
Our students transfer to UC Davis, UC Berkeley, UC San Diego, UC Santa Cruz, San Francisco State University (SFSU), San Jose State University (SJSU), CSU East Bay (Hayward), Menlo College, and Notre Dame de Namur University.
Program Learning Outcomes:
Here is what you should expect to achieve as a student in the Business Administration program:
- Design and manage business documents using current technology to engage in creative problem solving.
- Communicate an understanding of business concepts professionally through written, oral and visual presentations using current technology.
- Recognize ethical behavior in their chosen profession and behave in a socially responsible manner.
- Analyze business issues, interpret financial data and identify economic trends.
Transfer Success Tips:
Learn some tips and tricks on how to successfully transfer from a community college to your dream university courtesy of our very own Professor Cabrera in accounting.


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Keyboard ALT + g to toggle grid overlay
Read, write and convert data between widely used formats. Access aerial and satellite imagery and connect to web mapping and web feature services to take advantage of publicly available data. Import and export between GIS, CAD and other GPS surveying formats, including: ASCII; DWG; ESRI SHP, E00 and Arc/Info coverages; LandXML and GML; MapInfo MIF/MID and TAB; MicroStation DGN; Oracle; Ordnance Survey MasterMap (DNF) (GML2, read-only); SDF and SDTS (read-only); and Vector Product Format (VPF, read-only).
Point clouds
Create Catchment from Surface dialogue box
Industry Foundation Classes (IFC)


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Talk:Troll bridge
From Meta, a Wikimedia project coordination wiki
There are many wiki's out there.
What is the term used for this concept in wikimedia projects? either redirect it there, and list troll bridge as a possible synonym, or keep and link to standard terminology.
Mapping alternate terminology to standard terminology is a very important aspect of wikis. A wiki will not be navigatable to the author and the authors friends. It's also not hurting anything. AaronPeterson 12:47, 23 Jul 2004 (UTC)


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Chinese portals again block Pope comments
Page Tools
Chinese internet portals have again banned prayers and other comment on Pope John Paul II in what appears to indicate government concern that his death might stirr up too much religious fervour.
Popular portals Sina.com and Sohu.com's on-line discussion forums were flooded with messages of condolence over the weekend, but all messages have disappeared since Monday.
Sohu.com confirmed the company had censored the comments, but denied it was an order from the government.
"Religious issues are special. We are afraid of problems arising," said a Sohu official.
"We're afraid people who don't understand religion will make unreasonable remarks," he said.
"It's forbidden, the leaders from the top have forbidden it," one editor at Sina.com, the biggest Chinese portal, said, without specifying whether the order came from the management or the government.
Analysts said the order was likely to have come from the government and indicated its concern the Pope's death might become a trigger point for a religious revival.
The Chinese government broke diplomatic ties with the Vatican in 1951 and Catholics have since only been allowed to worship in the state-sanctioned church. Worshippers in the underground church loyal to the Vatican are frequently harrassed and imprisoned by the authorities.
Sister Beatrice Leung, a Taiwan-based Catholic professor, said there was a spiritual void in contemporary Chinese society and that religion could easily become a rallying point for social movements.
"In China, there are a lot of possibilities for these movements to cause social disturbance," she said.
"People are seeking religion to fill their hearts, this is one basic reason why the party is so sensitive," she said. "When they see religions flourishing, this is a threat to the party, and they are very much afraid.
"(In China), the moral leadership is missing, and the pope is highly praised as moral leader."
Rose Wu, director of Hong Kong Christian Institute, said the crackdown on religious discussions on the internet showed that China still regarded religion as a sensitve issue.
"They can't block them completely, but they have a high level of alertness and control," she said.
"And there is a fear that if these expressions and communications are allowed to continue too freely, the situation would be totally out of control."
Despite its lack of diplomatic ties with the Holy See, China offered its condolences over the death of Pope John Paul II and expressed its hope that relations with the Vatican could improve under his successor.
State-controlled Catholic churches were also allowed to hold remembrance masses for Pope John Paul II.
"When people felt the government was warm to the Vatican, they started to think, we want to say something about the pope too and this has aroused Beijing's fears," said Leung.
While most of the on-line messages posted during the weekend were prayers and words of appreciation and blessings, there were words of hostility also, criticising the Vatican for having diplomatic ties with China's rival Taiwan.
Get The Age home delivered for as little as $2.70 a week*


text: Hump Day Link Dump – Nov. 11, 2009 Posted on November 11, 2009 by Noah Dunker This week's links: PHP Library Interoperability Standards PHP Founder Rasmus Lerdorf leaves Yahoo Managing File Uploads with Zend Framework Teach yourself how to code (not PHP specific) A simple PHP Database class Helicon Ape: an Apache emulator for ISS. Why?! 😆


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What is glucose form photosynthesis turned into?
The raw materials/reactants for photosynthesis are ______ and _____ .
The sugar made by photosynthesis is
_______ .
Photosynthesis needs ____
aerobic respiration
What are the two reactants in aerobic respiration?
Which gas diffuses into leaves?
What green substance is needed for photosynthesis?
What does the chlorophyll do?
What substance is used by plants and animals for respiration?
rate of photosynthesis = ?
photosynthesis is faster than _____ in bright light.


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There's an unfamiliar face among the top 20 Ultimate Footy standings after three rounds of AFL action. Slotting into 19th position, just ahead of Brendon Goddard, Trent Cotchin and Dayne Beams is the unassuming Essendon number 20, Jackson Merrett.
Drafted in 2011 in the second round, Merrett is a prototype for the modern winger/half forward. 187cm tall, athletic yet lanky, a smooth mover around the ground. Like so many quality footballers before him, Merrett has shown this season that he has one attribute that many can't be taught – he can find the footy.
Merrett has started 2014 in sensational form, and this has translated to fantasy results. He's averaged 112 fantasy points over the opening three rounds – elite by anyone's standards not named Ablett or Swan. He's comfortably outscored the latter, defying his lowly preseason ranking.
Against Carlton on Sunday night, Merrett was unstoppable, racking up 35 disposals and 10 marks. Not that anyone from the Blues paid him any attention. Merrett lined up on the wing for centre bounces, time and time again, by himself. The Bombers would win the clearance, and Merrett would be in space, providing the link up and run.
It should come as no surprise, then, that Merrett is a product of the now-fabled football factory, the Geelong Falcons. Ablett, Hodge, Bartel and Jack Steven are just a few of the modern day greats who can trace their roots to the Falcons during their TAC Cup tenure. It's still early, but Merrett is on the path to adding his name to that vaunted list.
With 336 fantasy points this season to date, the young Bomber sits behind only veterans Paul Chapman and Nick Riewoldt among forward-eligible players. It's a lofty ranking, but one that offers a glimpse of what he might be able to achieve over the next 10 years.
2014 is his third year in the system, and the season in which young players tend to see a spike in their performance. However with the expansion clubs looting the majority of the young talent over the past four years, Merrett has flown under the radar. He was allowed to develop in the VFL. Having completed his apprenticeship, he's now showing he was what it takes to perform at AFL level.
This week Merrett will travel west to take on last year's runners up, Fremantle. The Bombers are flying up in 2014, and a clash with the heavyweight Dockers in Perth will be the ultimate test of Merrett's short career.
One thing is for sure. If the Dockers allow him as much time and space as Carlton did, then the footy will again find its way into the deft hands of the number 20.
Article supplied by Footy Prophet (www.footyprophet.com) – football analysis and opinion with a fantasy focus. Be a part of the game.


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American Jews have given a lot to Israel over the years. Though most of the attention has focused on financial and political support, we in fact appear to have other, more intangible things to offer the Jewish state.
Sometimes, it all begins with a song and campfire.
Two stories this week point to lessons Israelis have learned from American-style Judaism, in particular as it has developed in our summer camps. The joyful way Jewish life is celebrated proved so compelling to some visitors that they exported it back to Israel.
In one case, an Israeli who has spent the last nine summers as an emissary at Camp Tawonga near Yosemite discovered that young American Jews connect to Judaism in a way foreign to most secular Israelis. So he started ShabbaTLV, a music-driven monthly Shabbat celebration designed to appeal to jaded Tel Avivians.
It's been a success, and he plans to take the concept to other Israeli cities.
Another story profiles the summer camps in Israel run by the Reform and Conservative movements and patterned after American Jewish camps. That model includes not only the basics common to most camps in Israel and elsewhere, such as arts and crafts, sports and encounters with nature, but also the upbeat American approach to Judaism.
That means plenty of singing, praying and communal spirit.
In this way, secular Israelis get a taste of religious and cultural heritage, something many do not experience elsewhere. It doesn't make them more American; it makes them more well-rounded Jews.
There is a larger message here. While over the last century Israel has evolved its own culture — one that we treasure and respect — it is still a young country with room to grow.
Nobody wants Israel to become a mini-America. Yet as the camp examples show, Israel can learn from us, especially when it comes to nurturing and expressing Jewish identity.
Ask most secular Israelis about identity and they will scoff, saying that simply living in Israel gives them all the Jewish cred they need.
Yet the American model, in which Jews all along the spectrum of observance learn and celebrate the basics of their religious history and culture, can surely help secular Israelis connect with their faith, their heritage and themselves.
We will always value Israel's unique Jewish character. Thankfully, Israelis seem increasingly open to our own version, too.


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Anoush Anou Model
STU - ARTPhotographer Male Canberra, Australian Capital Territory, Australia
My Website: General photographyMy MM URL: http://www.modelmayhem.com/SniperStu
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About Me
Taking a sea change from (feathered) bird photography, which has developed my skills in speed and efficiency in capturing images in the field, to another world of beauty. I hope to deliver unique outcomes, capturing the inherent beauty of a subject, using personal techniques within the camera and not overly post producing unless required/requested. I travel and shoot light and enjoy excursions to interesting and beautiful places. If your portfolio needs that something 'a bit different', speak to me, let's collaborate. Contact me anytime on 0404 330 965 or via email email@example.com (NB - change in email address due to horrid hackers)
Example of work so far is at:
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some examples of bird photography can be found at this site...
Am willing to travel with enough notice though work around Canberra and the South Coast is preferrable.
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Kresge grant to improve Columbia neighborhoods
Some areas in downtown Columbia have higher crime rates than other parts of the capital city.
Researchers from the University of South Carolina are hoping to change that, with help from a $650,000, three-year grant from the Kresge Foundation. The grant will be used to help residents identify concerns, become more involved and create healthy spaces in their own neighborhoods.
"As much as it is about crime and safety, it's also about creating more opportunities for people to interact with one another, to develop relationships, trust and rapport," said Dr. Darcy Freedman, an assistant professor in the College of Social Work and one of the study's leaders. "Those things become the glue that keeps people together, promotes safety and reduces overall violence. The heart of this project is about creating community. As a byproduct, hopefully we'll see crime go down."
Freedman and her colleague, Dr. Ronald Pitner, also an assistant professor in the College of Social Work, are leading the project, collaborating with faculty from the College of Mass Communications and Information Studies and the department of criminology and criminal justice in the College of Arts and Sciences. The group will work with the Columbia Housing Authority to help implement the community-based, participatory study.
"The idea is to get people interacting more with each other, for residents to take ownership of the community and create healthy spaces in the community," Freedman said.
More than 1,000 people live in the public-housing neighborhoods that border downtown Columbia, the target communities for this study. While there are many assets in these communities, the area has fairly high rates of violent and property crimes and is plagued with dilapidated housing, graffiti, homelessness and vagrancy.
"Research has shown that residents that live in low-income, high-crime areas tend to withdraw and not interact with each other as often. This can lead to more neighborhood decay, greater perceptions of crime and, ultimately, higher rates of crime," Pitner said.
"We want to reverse that by having residents identify what their community concerns are, and to have them actively work together to change them," Pitner said. "We want to focus on community engagement."
The goal for the first year is to identify concerns about crime and safety in the community. This will be done through a methodology called PhotoVoice, in which teens and adults will document the strengths and concerns of their community through photographs. Their photographs will be used to spark discussions about what is going on in the community and what changes should be made.
That work has already started through a grant from USC's Arts and Humanities Grant Program that enabled seven youths in the community to start capturing aspects of their neighborhood through photographs. In the coming months, adults will also work on the PhotoVoice project, which will culminate in an exhibit that will open Jan. 18, 2011 at McKissick Museum.
During the second year of the grant, a community-empowerment center will be established to provide technical assistance to residents who want to improve their community.
"One of the interventions is going to be a community garden. Spaces that beautify the community, where people come together and build relationships, have been proven to reduce crime and violence in communities," she said.
In the final year, the community members will implement the ideas.
"Our approach is centered around sustainability," Freedman said. "We want to make sure whatever is developed can continue beyond the life cycle of the grant.
Also, a rigorous evaluation, including surveys, an environmental inventory and a police crime analysis, will be conducted at the beginning and end of the study to see how the neighborhood has changed.
"We hope residents will feel safer in their communities and will have a greater sense of ownership of their community," Pitner said. "When residents have that sense of ownership, they actively do things to make their community better."
The Columbia Housing Authority will partner with USC, providing space, feedback and support. The agency will also assign a project coordinator to work as a liaison with the university.
"One of the things we try to do is provide safe and affordable housing for our residents," said Taleshia Stewart, director of family self-sufficiency for the Columbia Housing Authority. "Getting the residents engaged in their community will increase the likelihood that our housing will be safe. Getting our people out of their homes, having them more engaged and taking ownership of the community is what will make this project a success."
About the grant
The Kresge Foundation is a $3.1 billion private, national foundation that seeks to influence the quality of life for future generations through its support of nonprofit organizations in health, the environment, community development, arts and culture, education and human services.
Kresge grant
- What: Three-year grant, worth $650,000, to help residents improve quality of life in neighborhoods
- Who: Kresge Foundation is a $3.1 billion private, national foundation that seeks to influence the quality of life for future generations
- Where: Public-housing neighborhoods in and around downtown Columbia


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'Vampire Diaries' Season 4 Adds Extra Episode, Teases Elena's Bloodlust
Here's some good news for fans of "The Vampire Diaries": the upcoming fourth season has been extended with an extra episode, bringing the total episode count for the season to 23.
It seems like the show might need it, too, with all the changes that are coming to Mystic Falls. The biggest one is Elena's transformation, which has been the talk of the offseason and the subject of many questions thrown at executive producer Julie Plec.
Plec sounded off recently about how Elena's bloodlust will affect Stefan, as she's more likely to act like the old him than the new him: "This is a guy who can't really get too close to human blood for too long without losing his mind, so it's like he's a guy who just got sober, and his girlfriend just turned 21 and wants to party, she said. "There are going to be some complications in their relationship as far as that."
Worse than that, Plec said that there will be a "powerful, surprising death sequence" during the premiere episode of the fourth season, wasting no time before creating some drama. Who's going to bite the dust?
The Vampire Diaries


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