text:
A two-alarm fire broke out Monday at a West Jordan garbage-processing plant.
About 20 people were working in the building when the fire broke out about 6:30 p.m. at Waste Management, Inc., 8750 S. 4000 West, said West Jordan fire battallion chief Steve Holmes. When firefighters arrived, part of the building was fully engulfed, he said. The workers had evacuated the building without injury.
The fire grew quickly because it broke out in a building where paper and plastic waste were being separated, Holmes said. Crews got control of the fire in about 20 minutes but were putting out hot spots in the garbage at least an hour later, Holmes said.
The fire left behind large amounts of burned garbage, which investigators will have to sift through to identify the source and cause of the fire, Holmes said. Investigators could not confirm early reports that the fire began on a conveyer belt.
Crews on Tuesday will try to estimate the value of the damage.


text:
What is in this article?:
- Navy Ships, Bayonets and Optimization
- Marketing Campaign Optimization
- Inventory Management
Marketing Campaign Optimization
But so much for definitions and theories, what are some practical examples?
Let's look at a marketing campaign optimization problem.
Any manufacturer has a limited campaign budget and wants the optimal return on their investments. But how do you do that?
Using OR techniques, a marketing professional can plan, prioritize and optimize customer contacts to maximize economic outcomes by making the most of each individual customer contact while considering business variables, such as resource and budget constraints, contact policies, the likelihood that customers will respond and more.
Effective consumer targeting leads to higher response rates, improved channel effectiveness and reduced spending. It also means fewer deleted emails and unwanted
direct mail solicitations. Segmentation and rules-based approaches to prioritizing marketing offers can't come close to delivering the same results as an OR math-based approach.
Optimization delivers a quantitative prediction about the impact of making
changes to constraints, such as budget or contact policy, so you can make decisions based on facts, rather than relying on instinct. You can easily create and modify what-if scenarios to see what revenue gains are possible if the campaign budget is increased by some percentage – or to see what impact a higher contact frequency will have on customer lifetime value.
Optimize across complex contact policies to avoid oversaturating customers and violating corporate governance requirements. Eliminate uncoordinated and conflicting communications, and incorporate relevant relationship factors – such as customer risk, advertising exposure and householding – into the optimization to ensure that valuable customers receive the best possible set of communications across every channel.

subset: commoncrawl


text:
Members of the Lake Mission Viejo junior sailing team swept the top three places in the "C" Class of the Lake Mission Viejo Yacht Club fleet championship series for 2012.
Twenty races were sailed throughout the year, with the "C" Class drawing 18 entries from sailors ages 12-82.
Christian Davoodian, Bella Murdy and twin sister Ali placed first, second and third respectfully.
Boys and girls of the Lake Mission Viejo junior sailing team are looking forward to another active sailing season where they will train and compete in four different classes of dinghy sail boats. The junior sailing team plans to race for the first time against other high school sailing teams in 2013.
For more information on the Lake Mission Viejo Yacht Club, visit lakemissionviejo.org.
Contact the writer: email@example.com or 949-454-7309


text:
|Information for:
|Campus Communicators
James Owens, Harold Franklin and Thom Gossom Jr. kick off the university's yearlong commemoration of 50 years of integration at Auburn.
Nearly 50 years ago, Harold Franklin arrived on campus to register for classes in the graduate school and became the first African-American student to enroll at Auburn University.
Other young men and women followed: Anthony Lee and Willie Wyatt Jr. came to Auburn as the first African-American undergraduate students in the fall of 1964, after playing an instrumental role in integrating Macon County schools as high school students; Josetta Brittain Mathews was the first African-American student to receive a graduate degree from Auburn in 1966; Henry Harris, a basketball player, was Auburn's and the Southeastern Conference's first African-American scholarship athlete in 1968.
Over the next 14 months, Auburn is celebrating these and other individuals who were involved in the integration of the university through a yearlong commemoration that includes performances, programs, lectures and other events that organizers say offer something of interest to everyone.
The celebration officially kicked off this month with the Women's Philanthropy Board's fall colloquium and luncheon featuring Thom Gossom Jr., the first African-American athlete to graduate from Auburn University and his wife, educator and entrepreneur, joyce gillie gossom, along with Marybeth Gasman, director of the Center on Minority Serving Institutions at the University of Pennsylvania.
Harold Franklin autographs programs at the Women's Philanthropy Board fall luncheon which kicked off the commemoration.
"Our history is our history, and I never back away from our history," said Gossom, who also is co-chair of the commemoration planning committee. "It doesn't mean that it's all positive. Sometimes you have to go through some things to learn what you should do and what you shouldn't do, but a large part of commemorating our history is to make sure we get the next 50 years right. That's why we look back because we want to be able to go forward as a global university."
"During the time the planning committee was meeting and we were talking about what the kickoff might be, I was looking for an opportunity that would provide a means for as many people as possible to be involved and the Women's Philanthropy Board fall luncheon provided that platform," said Paulette Dilworth, assistant vice president for access and community initiatives in the Office of Diversity and Multicultural Affairs. "There was a cross section of people from the institution and from the community, and that was the kind of audience I thought it was important to have because the commemoration is not just an initiative of my office or of one particular unit, but it is an Auburn University event."
Dilworth said that for her, events of the commemoration that bring to campus many of those who played a significant role in what happened during integration at Auburn are the most important.
"Having not attended Auburn University myself, having someone like Thom to co-chair the committee has been wonderful and so helpful to me in understanding some of that history from the people who were here," she said. "He's been really committed to making sure people who were significant during the time, like James Owens, Auburn's first African-American football player, and others are included in the programming."
Throughout the remainder of the fall semester, the Multicultural Center will share films and bring guest speakers to campus as part of their Watch and Learn and Lunch and Learn series. In January, the celebration will continue with a discussion forum to feature Harold Franklin, retired federal judge U.W. Clemon and attorney Fred Gray, as well as the events held as part of the university's annual King Week. The rest of the spring semester will offer films, exhibits, guest speakers and performances to involve both the campus and the greater community in the commemoration celebration.
"Sometimes when you land in a place, you wonder, 'Why am I here? What's my purpose?' and I understand now that for me, it was to be here to be a part of this," Dilworth said. "And for me, that is an honor. I don't know that – of all the institutions where I've worked – that I would have been a part of something as important as putting together something that would commemorate 50 years of history in one place."
— By Carol Nelson, Office of Communications & Marketing
Last Updated: Oct. 22, 2013


text:
Table of Contents
Form 8913 is used to request a credit or refund of the federal excise tax paid on long distance or bundled telephone service
that was billed after
February 28, 2003, and before August 1, 2006. You cannot request a credit or refund for the tax paid on local-only service
or charges in connection
with local-only service. See Definitions on
page 2.
You may request a credit or refund if you:
Have not received from the service provider a credit or refund of the tax paid on long distance or bundled service billed after February 28, 2003, and before August 1, 2006, and
Will not ask the service provider for a credit or refund or have withdrawn any request submitted to the provider for a credit or refund.
Requests cannot be filed on Form 8849, Form 720, or Form 843 for this credit or refund; the IRS will not process these claims. If you filed a claim prior to May 25, 2006, you or your representative should have received a letter from the IRS explaining how your claim will be processed. If you or your representative have not received a letter or an IRS agent has not contacted you, call toll-free 1-866-699-4096 for assistance.
There are two methods to figure your credit or refund on Form 8913.
Figure your actual credit or refund. You will need your phone bills for the 41-month refund period.
If eligible, you can figure your actual credit or refund using the Business and Nonprofit Estimation Method.
All of the following must file Form 8913 if they want to request a credit or refund of the federal telephone excise tax.
All corporations, partnerships, estates, trusts, and nonprofit organizations.
Any individual who can be claimed as a dependent by someone else. A person who can be claimed as a dependent is eligible to request a credit or refund of the telephone excise tax if the dependent paid the tax on long distance or bundled service. However, the dependent must file Form 8913 and figure the actual amount of credit or refund. A dependent cannot request the standard amount.
Standard amounts are available for individuals to request a credit or refund of the tax instead of figuring the actual amount
on Form 8913. See the
2006 Instructions for
Form 1040, Form 1040A, Form 1040EZ, Form 1040NR, Form 1040NR-EZ, Form 1040-PR, Form 1040-SS, or new Form 1040EZ-T, Request for Refund of Federal Telephone Excise Tax. However, individuals who want to request a credit or refund greater than the standard amount must file Form 8913. Individuals filing Schedule C, Schedule C-EZ, Schedule E, Schedule F, or Form 4835 may benefit by figuring the actual amount of credit or refund on Form 8913.
If a taxpayer died after 2005 but before filing a return for 2006, the taxpayer's spouse or personal representative may have to file Form 8913 (if he or she is not requesting the standard amount) and attach it to the individual income tax return for that taxpayer or to Form 1040EZ-T. For more information on filing for a deceased taxpayer, see the instructions for your individual tax return.
If the taxpayer died before 2006, Form 1041 must be filed for 2006, even if the estate is closed. Attach Form 8913 to that return.
If an entity was the subject of a merger or acquisition and it will not be filing a 2006 income tax return, the surviving or acquiring corporation must include on its Form 8913 any tax for the months of the refund period the dissolved entity was in existence and paid the tax. If the entity is no longer in business or is no longer in existence, the transferee must file Form 8913. The transferee must include any tax on long distance or bundled service from the entity no longer in existence with the transferee's own Form 8913.
A service provider is the person responsible for paying over the tax to the government, generally the telecommunications company
that provides
communications services to the taxpayer. A provider cannot use Form 8913 to request a credit or refund for long distance or
bundled service billed to
customers of the provider. See the Instructions for
Form 720.
Providers may request a credit or refund on Form 8913 for long distance or bundled service billed to the provider.
Do not attach any phone bills or other records to Form 8913. However, all taxpayers must keep records to support the credit or refund request.
Local-only service means (a) access to a local telephone system (but not private communications service) and the privilege of telephonic quality communication with substantially all persons having telephone or radio telephone stations constituting a part of such local telephone system, and (b) any facility or service provided in connection with such a service.
Local-only service includes the charges for the following services, even though they may be connected with long distance service.
Telephone amplifier.
Automatic call distributing equipment.
Special telephone.
Subscriber line charge (or access charge if separately stated).
A universal service fee charge is considered local-only service if it is separately stated on the bill for local-only service.
If local and long distance service is billed to a customer on a single bill, but the charges for local-only service and long distance service are separately stated, then the amount for local-only service is subject to the 3% communications excise tax.
Bundled service is local and long distance service provided under a plan that does not separately state the charge for the local telephone service. Bundled service includes plans that provide both local and long distance service for either a flat monthly fee or a charge that varies with the elapsed transmission time for which the service is used. Telecommunications companies provide bundled service for both landlines and wireless (cellular) service. If Voice over Internet Protocol service provides both local and long distance service and the charges are not separately stated, such service is bundled service.
The method for sending or receiving a call, such as on a landline telephone, wireless (cellular), or some other method, does not affect whether a service is local-only or bundled.
A PTC will be treated as bundled service unless a PTC expressly states it is for local-only service. Generally, the person responsible for collecting the tax is the carrier who transfers the PTC to the transferee. The transferee is the first person that is not a carrier to whom a PTC is transferred by the carrier. The transferee is the person liable for the tax and is eligible to request a credit or refund. For more information, see Regulations section 49.4251-4.
The holder is the person that purchases a PTC to use and not to resell. Holders are not liable for the tax and cannot request a credit or refund.
Example 1.
Z purchases a PTC from S. Z uses the PTC to place telephone calls. Z is a holder and cannot request a credit or refund.
Example 2.
S purchased the PTC from O. O is a transferee that purchased the card from R. R is a carrier. O is eligible to request a credit or refund. S cannot request a credit or refund because S did not purchase the PTC from the carrier.
For more information, see Notice 2006-50, which is available on page 1141 of Internal Revenue Bulletin 2006-25 at www.irs.gov/pub/irs-irbs/irb06-25.pdf.
|More Online Instructions


text:
Students Collect Memories Of Park Street School
05/03/10 7:34AM By Susan Keese
| Download MP3
(Host) Springfield's Park Street School is closing at the end of the school year, after serving the town's children for 115 years.
A great many memories can accumulate in that amount of time. For much of this year students at the school have been collecting those recollections.
VPR's Susan Keese has more.
(Keese) The history of a place like Park Street School is made up of little moments. Like the time in the cafeteria when Mrs. Bruso told the kids that the red in the red Jello was made from squooshed bugs.
(Porche) "Okay ready, get set, go."
(Kids read in unison) "My eyes popped out of my sockets as I stare at the quivering red guts"
(Porche) "Okay, who has something that they want to say about my mouth? Okay, yes!"
(Keese) Poet-in-residence Verandah Porche is helping these fourth- and fifth-graders preserve their own memories, as the last students to attend Park Street.
(Porche) "And also to help them document the experience of other people from the community in a more creative way."
(Keese) The students have been interviewing Springfield residents about the school, which also served as the town's high school for many years.
Residents like Frank Poole, a first-grader in 1939.
(Poole) "And when I went to Park Street School, it was not in this building. It was in a building over there that burned down. ... They had an organ in the building, a pump organ, and I came to watch the fire, and they threw the organ out the fourth floor window and it smashed all to pieces."
(Keese) Fourth-graders Logan Whitcomb and Samantha Mirra traced back even further.
(Logan) "And I think it's fascinating that before this school was here there used to be a mansion that burned down."
(Samantha) "And they decided to rebuild it as a school."
(Keese) That was in the late 1800s. Alexis Rowe , who's ten, says that's part of why the school is so important to the town.
(Alexis) "It's been here for a long time and it's really special to people that have been here when they were kids. And their grandparents went here and their kids and then their kids."
(Keese) The decision to close the historic building was difficult. The school is in bad condition.
When officials learned it would cost millions to bring it up to specs, they decided to consolidate Springfield's three elementary schools into two.
Fourth-grade teacher Alyson Bull had the idea that an oral history project might heal some of the sadness and honor the school's history.
Her students put up posters and invited anyone to come and share their memories on videotape.
Bull says they've learned a lot.
(Bull) "One woman said, it wasn't a problem to do your homework. There was no TV. So to see them think about that, what would that be like."
(Keese) The students learned about traditions, such as fifth-grade sleepovers at the end of the school year. And that in the old days, students could walk home for lunch. Here's Caithness Cammarata.
(Caithness) "In gym
class, if you didn't have white socks,
they would take a paddle and smack you."
(Keese) They also gained a new appreciation for the school's wide marble corridors, its architectural flourishes, its cavernous auditorium with its big stage and graffiti-covered seats. Logan Whitcomb:
(Logan) "You won't find a lot of schools like that."
(Keese) The students hope to make a documentary of their interviews as a gift to the town.
For VPR News, I'm Susan Keese.


text:
We started KiRi wanting to introduce local people to some of the truly exquisite food that we enjoy in Japan. Our food is prepared using the freshest possible ingredients which goes to the heart of our philosophy to realize the ultimate potential of our produce.
KiRi is the Japanese name for the tree known as Paulownia in Australia. Its also called the Princess Tree and has a reputation for being strong and fast growing. In Japanese tradition a Kiri tree is planted in the garden when a girl is born, and then when she is about to be married it is cut down and made into a dresser or chest of drawers as part of the wedding dowry she brings into the marriage.
|Copyright KiRi Japanese // Site Designed by M-Design
|142 Onslow Rd Shenton Park WA // 08 9388 2727


text:
Dismiss Notice
Welcome To CK5!
Registering is free and easy! Hope to see you on the forums soon.
Score a FREE Membership sticker when you sign up for a Premium Membership and choose the recurring plan.
wheels / lift
Discussion in 'Parts & Trucks Wanted' started by blazeonchevy, Jan 10, 2007.


text:
Sickle cell trait and your anemia should be worked up by a hematologist to determine if you are ready for surgery. If the hematologist clears you, then the surgery can be performed. Kenneth Hughes, MD Los Angeles, CA
I Have Sickle Trait and Anaemia Will I Be Able to Have a Bbl I Have Been Under General Anaesthetic Before with No Complications?
Doctor Answers 1
Sickle Cell Trait and Brazilian Buttlift
{{ voteCount >= 0 ? '+' + (voteCount + 1) : (voteCount + 1) }}
{{ voteCount >= 0 ? '+' + (voteCount + 1) : (voteCount + 1) }}
Learn more: http://www.hughesplasticsurgery.com/brazilian-buttlift-photo-galleries.php
These answers are for educational purposes and should not be relied upon as a substitute for medical advice you may receive from your physician. If you have a medical emergency, please call 911. These answers do not constitute or initiate a patient/doctor relationship.


text:
| Drug Approvals: Circumstances under which an active ingredient may be simultaneously marketed in both a prescription drug product and an over-the-counter drug product
|FDA Comment Number :
|Submitter :
|Mrs. B Lang
|Date & Time:
|10/12/2005 06:10:15
|Organization :
|Mrs. B Lang
|Category :
|Individual Consumer
|Issue Areas/Comments
| A. Should FDA initiate a rulemaking to codify its interpretation of section 503(b) of the action regarding when an active ingredient can be simultaneously marketed in both prescription drug product and an OTC drug product?
| I don't think it would be in the best interest of a person if a drug that is prescription should be sold over the counter. it is a prescription that has been tested and should remain a prescription
|B. Is there significant confusion regarding FDA's interpretation of section 503(b) of the act?
|yes, I don't think it should be so confusing for comsumers. Layman terms would better serve the public.
|C. If so, would a rulemaking on this issue help dispet that confusion?
| A. If FDA limited sale of an OTC product to a particular subpopulation, e.g., by making the product available to the subpopulation by prescription only, would FDA be able to enforce such a limitation as a matter of law?
|this is very confusing


text:
Try this command instead.aircrack-ng -a 1 -b 00:11:22:33:44:55 squishytest-01.cap
The asterisk is just used in case you have more than one cap file and wish to use them all.Code:aircrack-ng -n 128 squishytest*.cap
The only difference in WEP encryption that will affect the time it takes to crack the key is its actual length. As you are only using a 128 bit key you should easily be able to crack it in a few minutes. You will also want to make sure that you have gathered a substantial amount of weak IVs before you actually try to crack the key.Is there a difference in WEPs that make some hackable in 3 minutes whereas mine is still hanging in after after 30+ minutes?
I take it that you mean that you are able to inject packets and can see the amount of data packets in airodump-ng building up rapidly?aireplay-ng -3 b 00:14:6C: DE: D1:A8 -h 00:11:22:33:44:55 rausb0 (success)


text:
Use the product locator below to find your favorite SUDAFED® brand products at a store near you.
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text:
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|Home » Discuss » Topic Forums » Election Reform
|KatieB (431 posts) Send PM | Profile | Ignore
|Sat Jan-08-05 07:09 PM
Response to Reply #55
|75. Thank you - this is SO important for us to get a sense of who supported
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text:
|Page (1) of 1 - 03/26/03
|email article
|print page
Final Cut Pro Quick Tip #18Color Correction Freebie
If you (or your videographer) were a goof and didnt white balance your camera correctly when you were out in the field, you could end up with footage that looks blue, orange, green or worse. In the old days, you would have tried to run the video through a Proc Amp to try and fix the problem. Today you can do it in Final Cut Pro providing you have a reference for what black and white should be.
Some videographers carry a Chip Chart with them on location. A regular chart has an 11-step progression from absolute black to absolute white, with neutral gray in the center. With these three shades, you have all you need to do basic color correction in Final Cut Pro (or other application).
How to use the chart on location
When you are out shooting, make sure you record a couple of seconds of the Chip Chart to tape. Make sure that the Chip Chart is being illuminated by the Key light, and that no colored gels or light sources are shining on the Chart. If the Key light does have a gel on it, remove the gel to get the shot and then replace it before shooting your scene. If you shoot the chart with a colored gel in place, you will defeat the point of using a gel in the first place.
How to use the chart in Final Cut Pro
When you digitize the footage, make sure you also digitize the chip chart you shot on location. To color correct your footage, apply the Color Corrector Three Way filter to the Chip Chart clip. Then use the eyedroppers for the Black, Mid, and White to select the corresponding color on the chart.
This will correct the Chip Chart clip. To correct your footage, you can simply apply the effect to other clips in the Timeline by following the instructions outlined in Final Cut Pro Quick Tip #7.
Your Freebie
Since you have been so patient, here is your free DMN Chip Chart. This is a simplified chart that only has white, black and neutral gray. I suggest you print this out on heavy paper stock (like a matte photo paper) and make sure you have plenty of ink in your cartridge. If the black doesnt come out pure black on your print out it will cause you problems later on.
|Click image to download the full sized DMN Chip Chart. This is a large image. After it opens in the new window, Right+Click the image and select "Save As". Open in your favorite graphics program and print.
Here is a current list of the Final Cut Pro Quick Tips to date:
Final Cut Pro Quick Tip #1: Texture Treatments to Enhance Video Productions
Final Cut Pro Quick Tip #2: Using Markers to Quickly Edit a Music Video
Final Cut Pro Quick Tip #3: Import Your Music the Right Way
Final Cut Pro Quick Tip #4: Nesting Helps Manage Longer Projects
Final Cut Pro Quick Tip #5: Keying Explained
Final Cut Pro Quick Tip #6: Configuring Your Scratch Disk
Final Cut Pro Quick Tip #7: My Favorite Effects
Final Cut Pro Quick Tip #8: De-Interlacing
Final Cut Pro Quick Tip #9: Color Correction workflow tips
Final Cut Pro Quick Tip #10: Locating files in the Timeline
Final Cut Pro Quick Tip #11: Backing up at project end
Final Cut Pro Quick Tip #12: Exporting to After Effects
Final Cut Pro Quick Tip #13: When is title safe, not title safe?
Final Cut Pro Quick Tip #14: Storyboard your edits and then edit in an instant
Final Cut Pro Quick Tip #15: Join Through Edits
Final Cut Pro Quick Tip #16: Exporting to Pinnacle Thunder XL
Final Cut Pro Quick Tip #17: Marking Clips
When not working deep in the labs of the DMN Central Division testing the latest and greatest software/hardware products Stephen Schleicher can be found at the local university teaching a few courses on video and web production. He can be reached at email@example.com. You can also visit him on the web at www.mindspring.com/~schleicher
Page: 1
Stephen Schleicher has crossed the country several times over the last couple of years going from Kansas to Atlanta , Georgia, and Southern California. In his time traveling, he has worked as an editor, graphic designer, videographer, director, and producer on a variety of video productions ranging from small internal pieces, to large multimedia
corporate events.
Currently, Stephen shares his knowledge with students at Fort Hays State University who are studying media and web development in the Information Networking and Telecommunications department. When he is not shaping the minds of university students, Stephen continues to work on video and independent projects for State and local agencies and organizations as well as his own ongoing works.
He is also a regular contributor to Digital Producer, Creative Mac, Digital Webcast, Digital Animators, and the DV Format websites, part of the Digital Media Online network of communities (www.digitalmedianet.com), where he writes about the latest technologies, and gives tips and tricks on everything from Adobe After Effects, to Apple�??s Final Cut Pro, LightWave 3D, to shooting and lighting video.
He has a Masters Degree in Communication from Fort Hays State University in Hays, Kansas. As a forward thinker, he wrote his Thesis on how Information Islands and e-commerce would play a major role in keeping smaller communities alive. This of course was when 28.8 dialup was king and people hadn�??t even invented the word e-commerce.
And, he spends what little free time he has biking, reading, traveling around the country, and contemplating the future of digital video and its impact on our culture. You can reach him at email@example.com
Related Keywords:Final Cut Pro, quick tip, chip chart, color correction, schleicher, stephen schleicher
Source:Digital Media Online. All Rights Reserved


text:
Health care act a lifesaver for Fishers woman
Many people are trying to understand just how the new health care law will affect them.
Eyewitness News is committed to helping central Indiana families by exploring different issues though our "Your Health Your Choice" series.
One woman shared her experience with Eyewitness news reporter Mary Milz on why she's so outspoken about the new law.
Chelsea Wheeler looks forward to time on the boat. Thursday, the 22-year-old from Fishers, took a spin around Lake Winona with her parents.
"I absolutely love it," she said. "Just coming out, feeling good and relaxing."
That hasn't always come easy for the recent Ball State graduate. Once inside her parent's new lake home, Chelsea began pulling pill bottles out of her purse, noting, "This I take every day. This one is for infection and this one is for sleep."
She takes nine different medications every day.
Pointing to two bottles, she said, "For these alone, it would easily be $3,000 a month."
Chelsea lives with chronic kidney disease.
She said, "When I got sick, I was 13 and it was kidney failure."
Doctors discovered Chelsea had only one kidney. She spent her teen years in and out of hospitals. Her health stabilized in college, but during her junior year, it took a turn. Chelsea needed a transplant. Her mother was the donor.
Looking at some of the many photographs her father took at the time, Chelsea pointed to one where she and her mom were in their hospital gowns hugging just before going off to surgery.
She recalls, "Both of us were emotional because I was scared I would lose her."
She didn't. Both are fine, but Chelsea's medication does cause tremors.
"Usually it's just shaking hands, but sometimes it goes up my arms and body," she said.
Her biggest concern now? Repeal of the Affordable Health Care Act, which Chelsea knows is highly controversial.
"People bring it up to me and they don't realize, if it goes away, it would be a world of hurt for me, literally," she said.
While Chelsea has a good job, because she's a contract employee she's not eligible for insurance through the company. With the new law she can continue on her parents' plan until she turns 26. It pays for all her meds, including those very expensive anti-rejection drugs.
"Rejection happens really quickly if you don't take them every day," she said. "I would die without them."
Chelsea also can't be denied coverage for a pre-existing condition or face lifetime limits. Her medical costs so far? $600,000 and climbing. She said the odds of needing another transplant are high.
"My entire life is based on getting medical care and without the Affordable Health Care Act I would not be able to do it," she said. "I'd be drowning in debt trying to pay by myself."
While Chelsea realizes many people oppose the law for various reasons, she's convinced for her and others living with chronic disease, "It's a lifesaver."


text:
- Home /
- Recipe & DIY /
- Valentines Day /
- Champagne with Love Party Favo...
Champagne with Love Party Favor
Champagne's not only for celebrating, but a bit of bubbly adds a touch of luxury as well!
Champagne's not only for celebrating, but a bit of bubbly adds a touch of luxury as well!
Giving small bottles of champagne or sparkling wine as party favors is going to keep your guests in the celebratory mood even after they've left. Guests will love showing it off and might even reserve it for a bit of unexpected fun the next time you visit!
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Wrap these splits up with a bit of ribbon and sparkle, and they'll be even more treasured. For a simpler design, leave off the doily heart when you wrap these beauties up.
- Champagne Split (small bottles of champagne or sparkling wine)
- Clear cellophane
- Rubber band
- 7 inches of red ribbon
- 6-inch doily
- 1 sheet White cardstock
- 1 sheet Red cardstock
- Heart shaped scrapbook punch
Step 1: Every champagne split bottle at the store will be a slightly different size. You'll want to adjust the size of your cellophane square accordingly. Place the bottle in where you think the center of your square is and pull the corners up to where they reach an inch or two over top of your bottle. Use the rubber band to keep the edges together and up around the bottle. Tie your length of ribbon around the neck of the bottle.
Step 2: For the lacy paper heart detail, accordion fold the doily then fold in half so it makes a heart shape. Glue the doily together in the middle so it retains its shape. Punch a heart from your white cardstock and glue to the doily heart.
Step 3: Cut a 2.5x8.5 inch strip of white cardstock. Use the heart shaped scrapbook punch to punch a heart in the center of the white cardstock strip. Cut a small square of red paper slightly larger than your heart punch and tape in place so the entire heart opening is covered.
Step 4: Turn the paper over and wrap around the champagne bottle. You can either use a really strong tape, or a line of hot glue to get it to stick.
More Lovely Champagne Gifts:
Champagne Truffles from Fannie May
Champagne Celebration Strawberries from Fannie May
Jennifer Kelly Geddes has hosted Christmas cookie swaps, New Year's open houses, Thanksgiving for 22, and all manner of dinner parties in her Manhattan and Ghent, NY homes.Read More »


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Jewell's steady hand useful for balancing act at Interior
When President Obama nominated Sally Jewell as Interior secretary last week, he chose a woman not unlike him: smart, low-key and with a self-deprecating wit.
In a 2011 speech at the University of Denver, Jewell quoted Rachel Carson's "Silent Spring" to argue that Americans have avoided the more-difficult road "less traveled by" that assures the Earth's preservation. She underlined that point by showing a slide of a glacier from her recent jaunt to South America and Antarctica, acknowledging ruefully, "Our carbon footprint was dreadful."
Jewell, chief executive of Kent-based retailer REI, also took a less-traveled road to the Cabinet nomination. She is not known as a top political fundraiser and never ran for office. But she long has hobnobbed in Seattle power circles and is a regular donor to Democratic politicians, including Obama.
Her work with influential conservation groups and other causes, along with a broad business background, caught Obama's eye during his first term. People close to Jewell believe Obama considered her for the Interior Department job four years ago.
Later, in 2009, he invited Jewell to the White House to discuss health-care reform.
As CEO of REI, Jewell oversees a $2 billion company with nearly 130 stores in 31 states and 11,000 employees.
"The fact that she's from the private sector was a major consideration for the administration," said Costco co-founder and Chairman Jeff Brotman, who served more than a decade with Jewell on the University of Washington Board of Regents and recently participated in the White House's vetting of her. "They've been criticized roundly for not having enough people from the business sector, and they can check off that box with Sally."
Brotman noted that Jewell has been to his Medina home for campaign fundraisers twice since 2008, giving her the chance to meet both Barack and Michelle Obama.
If the Senate confirms her, Jewell will take over an organization that's one of the government's biggest sources of revenue other than taxes. In 2011, the Interior Department's Bureau of Land Management brought in $7 billion from leasing rights for oil, gas, coal and minerals, and recreation fees.
Jewell, who has mostly avoided controversy throughout her career, also will face the dueling demands of protecting public lands while tapping the wealth buried beneath.
That tension reared its head Thursday, when Alaska's Sen. Lisa Murkowski called Jewell to say she would hold up the nomination unless the Interior Department approves a 20-mile road across the remote Izembek National Wildlife Refuge on Alaska's Aleutian Peninsula.
Tom Kiernan, president of the National Parks and Conservation Association in Washington, D.C., said Jewell won't be easily cowed by political pressure.
"Sally is strong, smart and wonderfully assertive," said Kiernan, who helped recruit Jewell to his board eight years ago.
Family factor
Jewell, 56, was born in England as Sally Roffey and moved to Seattle four years later when her father, an anesthesiologist, took a fellowship at the University of Washington.
"He thought of nature as a wonderful laboratory," Jewell recalled to The New York Times in 2007. "So when I was 9, my parents started sending me on educational camping trips."
She graduated from Renton High School in 1973. And in 1978, she received a degree in mechanical engineering from the UW along with her soon-to-be husband, Warren. They both moved to Oklahoma and took jobs with Mobil Oil.
"Neither of us felt bad about working for an oil company," she told The New York Times. "In fact, I remember thinking how ironic it was when Greenpeace started using gasoline-powered boats to block oil tankers, or when people drove to protests against oil drilling, or when people who built wood houses and read books said no one should ever cut down trees."
Sally and Warren Jewell, who have two adult children, returned to Seattle in 1981, and she joined the former Rainier Bank to help evaluate loans to energy companies. She worked at the bank until Security Pacific bought it in 1987, then left Security Pacific when BankAmerica bought it five years later.
Jewell headed Washington operations at another bank, West One, for nearly four years, and in 1996 joined Washington Mutual to lead a new commercial-banking group. Former WaMu executive Craig Tall said she impressed him as someone with "a very nice style who gets things done."
Even so, WaMu later decided it couldn't compete with the likes of Bank of America or Wells Fargo in commercial banking, and Jewell saw a better opportunity elsewhere. In 2000, she became chief operating officer at REI, the outdoor-equipment chain.
"REI is a real cultural fit," she said in 2007. "I still spend a huge amount of time in the outdoors. My son Mark takes me mountain climbing for Mother's Day each year."
About 25 years ago, local civic leader Jim Ellis turned to Jewell and other environmentally minded business people to help create the Mountains to Sound Greenway Trust. It aims to preserve the forested landscape along Interstate 90 from Cle Elum through Snoqualmie Pass to Seattle.
"She and I were put on that board in the beginning, when we were 33 and 34 years old, respectively. So we got quite an education," said environmental lawyer Bill Chapman, the trust's president.
"She's certainly driven to fulfill her commitments," Chapman said. "And it's all the more impressive that she seems to do so without betraying any ego whatsoever. It's about getting to a solution on a problem."
Jewell also helped create another Seattle nonprofit, the Initiative for Global Development (IGD), which promotes private investment in developing nations to fight poverty. Its leadership council is co-chaired by former Secretaries of State Madeleine Albright and Colin Powell.
"The Interior Department is all about balance," said Bill Ruckelshaus, who once headed the Environmental Protection Agency, noting the tension between preserving federal lands for recreation and wildlife and the need to allow oil drilling and mining. "She's seen all sides of that so she'll have the ability to weigh what needs to be done as secretary."
Jewell's work with Mountains to Sound put her on REI's radar, and in 1996 she joined its board, eventually leading to the COO and CEO posts.
"With her experience in banking, she could offer a perspective we didn't have at the time. We were all homegrown employees," said Dennis Madsen, REI's CEO from 2000 to 2005, when Jewell succeeded him.
"She wants to make a difference, so she seeks out challenges. She's not a status-quo person," he said. "She's always pushing."
During Jewell's tenure, REI nearly doubled its annual sales from $1 billion in 2005 to $1.8 billion in 2011 and added 71 stores, including one in Manhattan.
Former U.S. Rep. Norm Dicks, who served for decades on the House Appropriations Interior subcommittee, said he was "pleasantly surprised" by Jewell's nomination, contrasting her business background with the usual pick of established Western politicians.
The Bremerton Democrat said part of Jewell's appeal to the Obama administration may be that she doesn't have a controversial political record that critics can pick apart.
The administration also has been under pressure to add women to the Cabinet.
"I'm not saying that was the deciding factor, but the reality is he said he was going to have a very diverse Cabinet and the first few picks were all men," Dicks said.
During Wednesday's nomination announcement, Obama mentioned that Jewell mountains in Antarctica, "which is just not something I'd think of doing," he added, drawing laughter. "Because it seems like it would be cold, and I was born in Hawaii."
Chapman, who was on that 2010 expedition, recalls how they climbed Vinson Massif, Antarctica's highest mountain, in nine days, but political unrest in Chile prevented them from returning home on an airplane for nearly three weeks.
"Every day we got a briefing that it turned out it wasn't going to be today but maybe tomorrow," Chapman said.
To pass time, Chapman and Jewell read books, went skiing, climbed other peaks, even invented a game using dinner plates as Frisbees.
"She's just a very steady hand and a good partner," he said.


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International Operator Services
Home Country Direct Services:
NCIC offers a completely IP-based Home Country Direct LIDB Validation service allowing PTT's to validate collect calls to the USA, Canada, UK and Puerto Rico over the public internet and terminate the calls through NCIC's network with a substantially higher settlement payment than has been realized in the past using traditional TDM / C7 connections. Additionally, NCIC has obtained many new collect call agreements with LECs / OCNs in the USA and Canada providing a higher amount of billable collect calls to phone companies. This means PTTs will have a higher completion rate of collect calls and less call rejections using NCIC's billing and validation services.
As part of the validation and billing services, NCIC has obtained agreements for collect billing to many of the cellular / mobile phone providers is the USA. NCIC now offers settlements of up to $4 per call for collect calls to AT&T Wireless, Cingular, Sprint / Nextel, US Cellular, Boost Mobile, T-Mobile, Alltel and Cricket Mobile. This new service can allow you to increase your collect call completions up to 80%.
Inmate Telecommunications Platform:
NCIC's completely redesigned VOIP-based, automated inmate telephone platform is able to support over 20 languages and can work in any country in cooperation with the local telephone company. The platform allows jails to sell debit / prepaid calling cards to inmates via the commissary service or the inmate's family is able to purchase calling time via our web-interface using a major credit card, debit card or Western Union.
The inmate telephone platform offers a full range of security and management features, such as:
Live call monitoring
Call recording
Call timers
Call detail reporting
Call reporting search features by inmate or destination numbers
Local and international calling
Live call blocking
Mobile phone call blocking
International collect calling to various countries
Kiosks for cash and credit card transactions
Visitation phone management and recording
Station specific management allowing deactivation / shutoff during specific times of the day
Ability to limited destination numbers by inmate
Automated Personal Identification Number (PIN) management system for call controlling
Custom branding with facility name
For the inmate VOIP telephone platform, NCIC can either co-locate the equipment at your facilities or maintain the equipment in the USA. NCIC provide VOIP compatible security phones to place at the prisons. NCIC also guarantees 100% fraud-free services.
Hospitality Operator Services and Card-Pay Phone Services:
NCIC has expanded upon it's current international operator service platform by adding VOIP capabilities and collect calling to mobile / cellular phones. NCIC utilizes its own multilingual, live operator center based in the USA and can offer custom features and branding for hotel chains or carriers. With the easy access to a live operator, our customers experience higher call completions and higher customer satisfaction. NCIC is also expanding upon it's popular 800-Call4Less product to the international market in order to offer low-priced international calling to PTT's for marketing on their public pay phones.
Using the 800-Call4Less product in conjunction with card-reader public pay phones, many of NCIC's airport and resort customers have experienced revenue increases by over 300%.
Furthermore, NCIC has secured agreements with several international carriers to offer DID origination from over 50 countries worldwide with unlimited capacity.
Network Communications International Corp. * P.O. Box 551 * Longview, Texas 75606 * Email:


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Business dashboards enable management transparency which in turn allows the entire user base to "call out" unacceptable levels of performance. We are seeing this in a major way with the Federal IT Dashboard. Since the launch, there has been quite a bit of focus on the "red" indicators showing up on the dashboard charts for the various agencies. Secretary of Veteran's Affairs, Eric K. Shinseki has taken major action in halting bad projects – probably to head off negative press. And of course, unless the VA is the only government department with problematic I.T. projects, watch for other departments to cancel their projects as well.
In a blog post titled "Evidence-based Decisions", Federal CIO Vivek Kundra announced that the new Federal IT Dashboard has identified 45 information technology projects that are being immediately halted. These projects are either so behind schedule or over budget that they cannot continue until a determination is made as to whether or not they are worth it.
The 45 projects belong to the Veterans Affairs Department and total $200 million in budget. The worst project identified is over 17 months late and 110% over budget.
Here's a screenshot of the top page of the dashboard showing the Veterans Administration bar charts. Notice all the red in the bottom bar:
These decisions come about 2 weeks after the launch of the Federal IT Dashboard. Kundra credits the role of the I.T. dashboard in identifying the problem projects, but cautions that a business dashboard is not a substitute for good management.
"We were able to catch these contracts, in part, thanks to our new tool, the 'IT Dashboard,' which helped shed light on the performance of projects across the federal government," Kundra wrote.
If you are just hearing about the IT Dashboard for the first time, it allows you to see which IT projects are working and on-schedule (and which are not), offer alternative approaches, and provide direct feedback to the chief information officers at federal agencies.
Given the size and complexity of the federal IT portfolio, the challenges we face are substantial and persistent. The dashboard is not a substitute for good management. Its value comes from leaders who use the information to make tough, evidence-based decisions on the future of IT investments.
The VA's announcement is part of a broader effort by the Administration to make the federal government more transparent and to boost accountability and drive better performance. From IT accountability to personnel and contracting reforms, the administration is committed to providing better value, efficiency, and effectiveness for taxpayers' dollars.
Hubert Lee
The Dashboard Spy
PS. New Book on Dashboards: Business Dashboards: A Visual Catalog for Design and Deployment


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New Delhi, July 5 (ANI): The Janata Dal (United) on Sunday termed the demise of journalist Akshay Singh as a 'heart-wrenching' incident and stated that his death has showed the power of politics.
"It is a heart wrenching incident and it shows the power of politics. Such scam [like the Vyapam scam] cannot be buried with such incidents. A high level committee should be formed where people will have their trust. This scam has brought out the real face of BJP government in Madhya Pradesh. I think that media will face this with all its strength," JD (U) leader Ali Anwar said.
Akshay Singh, a journalist with the TV Today Group, died suddenly yesterday when he had gone to take an interview of the family of a slain Vyapam scam accused in Jhabua district of Madhya Pradesh.
Reports say that Singh felt chest pain while he was taking the interview. He was taken to the Meghnagar hospital, where he was declared dead on arrival. (ANI)


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Mental Health
Have Mental Health Questions? Ask a Psychiatrist Online
Good evening. I'm online and would be happy to try and help. Please let me know when you are in the room and we can discuss this further
Hello and thank you for joining me in the room
I am available right now.
Would you mind very much if I asked a couple of questions to gain further understanding of the situation?
I do not mind.
Thank you
First...when would you say that the verbal abuse against your husband began?
I think that it has actually been going on for years. Even while he was living with his ex-wife. I noticed verbal abuse towards him from her. I didn't realized the children were doing it too. I just noticed it when he and I began dating and announced our engagement.
Thank you. What form does the verbal abuse take on? Is it in relation to the divorce or other things?
Yes. It in relation to their divorce and his decision to not have contact with his ex wife. It also seems to be in relation to the fact that my husband has taken control of his life and is not allowing them or his ex-wife to control him any longer.
Thank you. That was my impression but it was important to confirm it from you. It seems that his children are projecting their anger at the divorce itself onto their father which is completely wrong of course. Especially given the fact that the divorce was likely a result of her own verbal abuse and her infidelity. Does that sound to be accurate?
Thank you. At this point does your husband still help them when they come to him for anything?
They don't come to him for anything at this point. He was helping them in the past, mainly financially. They would go to their mother for everything else as she always said "yes" to everything and then expected my husband to fulfill all of their needs and wishes. His daughter did come to him in the past for advice but not his son. His son made all of his own decisions with the help of his mother,.
thank you. It sounds as though the children learned the behavior from the ex wife and then it took off when they found they could get what they wanted regardless of how the engaged or behaved. You mentioned that they even berated your husband's sister when she voiced that what they were doing is wrong?
Yes, this is correct.
Do your husbands other siblings recognize this as well? The severity and wrong behavior of the children?
His siblings recognize the bad behaviour but his older brother in particular says that he will still have a relationship with my husband's son and treat him respectfully. His family for the most part are very polite and respectful people and in some cases not very assertive. They are educated people and not used to this kind of behaviour and really don't know how to deal with it.
I can sincerely XXXXX XXXXX behaviors....sounds to be the opposite of his ex wife...and I'm only speculating but my impression is that her family is probably like that as well
has the family as a whole been in counseling prior to the divorce?
I believe that her family may be like that as well but from what they display on the outside you may not know it. The family as a whole has never been to counselling before the divorce. It was however understood by my husband's family that his ex-wife was abusive and dysfunctional.
My suggestion at this point is for your husband to meet with his siblings who all seem to be reasonable and explain to them that he has tried everything to reason with the children, be supportive of them, etc. which has had no impact and no positive results. They will likely continue this behavior if there are no consequences. It's important that he explain this to his siblings and then to inform the children that he will be cutting ties with them until they recognize the harm that they are causing him and the impact this is having on his life and likely health. Given the fact the stress endured likely impacts his blood pressure and other physical manifestations.
He can do this either face to face, email or letter...whichever he is comfortable with. These are not children...they're adults and SHOULD know the difference between right and wrong and they're choosing to ignore that to the detriment of their father. If this persists it will only worsen and will certainly take it's toll on your husband as psychological stress will almost ALWAYS manifest into physical conditions which can and often are threatening to one's well being
Thank you for this advice. From my past experience I know that his children will respond with an answer like "what about the harm that you are doing to us!" They are very narcisstic people. His siblings may also take the children's side as they are very compassionate people. Do you think it logical that my husband ask his siblings to have no contact with the children until they recognize what they are doing is wrong?
I think it's reasonable for your husband to meet with his siblings and to explain things precisely the way I have identified them...especially in relation to the stress causing physical conditions, the more stress he has the more his arteries constrict.
I woudl suggest that he tell his siblings the intent and that he would not hold any ill will toward them if they decide to maintain contact with the children but that the best thing for him to do is to take a break from them.
May I offer another suggestion? And you are most welcome for the advice
Yes. Please.
I would suggest recommending to your husband to consider seeing a therapist individually as even though this is the healthiest approach to take...it will still take a toll on him given that they are still his children despite their inexcusable behavior. He's only human
May I ask...do you have any other questions I can help with?
No. That is all. Thank you very much for your help.
You are most welcome. I'm very happy that I could help and you can end the chat by clicking the accept button if I've answered your question to your satisfaction. I wish you and your husband the very best and I wish you well


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Epigenetics is defined as heritable changes in gene expression that are, unlike mutations, not attributable to alterations in the sequence of DNA. The predominant epigenetic mechanisms are DNA methylation, modifications to chromatin, loss of imprinting and non-coding RNA. Epigenetic regulation of gene expression appears to have long-term effects and wide-ranging effects on health. Diet and environmental exposures may potentially alter the level and scope of epigenetic regulation, thus interesting developments in the study of epigenetics might explain correlations that researchers have found between lifestyle and risk of disease. Aberrant epigenetic patterns have been linked to a number of digestive diseases including Barrett's esophagus, cirrhosis, inflammatory bowel disease, and numerous gastrointestinal malignancies. In fact, many exciting discoveries about epigenetics in general have been made by studying diseases of the gastrointestinal tract and hepatobiliary tree. Epigenetic modifications of DNA in cancer and precancerous lesions offer hope and the promise of novel biomarkers for early cancer detection, prediction, prognosis, and response to treatment. Furthermore, reversal of epigenetic changes represents a potential target of novel therapeutic strategies and medication design. In the future, it is anticipated that innovative diagnostic tests, treatment regimens, and even lifestyle modifications will be based on epigenetic mechanisms and be incorporated into the practice of medicine.
Epigenetics is defined as heritable changes in gene expression that are, unlike mutations, not attributable to alterations in the sequence of DNA. The predominant epigenetic mechanisms are DNA methylation, modifications to chromatin structure, loss of imprinting, and non-coding RNA [1]. An important feature of epigenetic modifications is that they are heritable between mother and daughter cells (mitotic inheritance) and between generations (meiotic inheritance). Epigenetics is one of the explanations how cells and organisms with identical DNA can have such dramatic phenotypic differences. Diet and environmental exposures may potentially alter the level and scope of epigenetic regulation, thus interesting developments in the study of epigenetics might explain the correlations the researchers have found between lifestyle and risk of disease [2]. In addition, epigenetic regulation of gene expression has emerged as a fundamental pathway in the pathogenesis of numerous diseases, and in particular malignancies [3,4]. Diseases of the digestive system are no exception, in fact many exciting discoveries about epigenetics in general have been made by studying cancers of the gastrointestinal tract, liver, and hepatobiliary tree. Epigenetic modifications of DNA offer hope and the promise of novel biomarkers for early cancer detection, prediction, prognosis, and response to treatment. Furthermore, reversal of epigenetic changes represents a potential target of novel therapeutic strategies and medication design [5]. There has been an explosion of data and studies published in the last decade regarding the epigenetic mechanisms and their involvement in the development of phenotypes and diseases. The current report aims to provide an introduction to the field of epigenetics, with examples of some the most salient and provocative studies related to this topic.
DNA methylation is the covalent addition or subtraction of a methyl group to a cytosine nucleotide in a sequence of DNA. Methylation is controlled by a family of specific enzymes known as DNA methyltransferases (DNMTs). In vertebrates, addition of a methyl group only occurs at a cytosine preceding a guanine (CpG dinucleotide) [1]. Regions of the genome rich in sequences of a cytosine preceding a guanine are known as CpG islands. In fact, CpG islands exist in the promoter regions of approximately half of all genes.
Approximately 80% of CpG dinucleotides outside of promoter regions are methylated under normal physiologic circumstances. Genome-wide decreases in methylation, or hypomethylation, are most functionally relevant when they occur in coding regions of genes, leading to alternative versions or levels of messenger RNA. Global hypomethylation of the DNA from the tumors of patients with colon cancer was one of the first epigenetic abnormalities to be described [6]. It is theorized that hypomethylation contributes to carcinogenesis by favoring mitotic recombination, leading to deletions, translocations, and chromosomal rearrangements – collectively known as genomic instability. DNA hypomethylation (also known as demethylation) is also associated with activation of proto-oncogenes, such as c-Jun, c-Myc, and c-Ha-Ras [7]. Overall, most DNA in tumors is hypomethylated, with occasional gene-specific hypermethylation (fig. (fig.1)1) [8]. In general, hypomethylation increases as a tumor progresses. Accordingly, hypomethylation of repetitive DNA elements such as SAT2, LINE1, and ALU occur in the multistep process of hepatocarcinogenesis, and correlates with a poor prognosis [9].
The addition of methyl groups, or hypermethylation, can be highly specific to a particular gene. Hypermethylation of CpG islands in the promoter region of a gene can result in transcriptional silencing of the gene, and subsequent loss of protein expression. Thus, hypermethylation of tumor suppressor genes is now recognized as a means of gene-silencing alternative to mutation or allelic loss [10]. The methyl groups project into the major groove of DNA, therefore changing the biophysical properties of DNA. These changes can positively or negatively affect the binding capabilities of DNA and certain proteins. For example, if RNA poylmerase 1 is unable to bind to DNA correctly, then the process of transcribing DNA into RNA is altered. During mitosis, methylation patterns are copied from the mother strand of DNA to the daughter strand of DNA by DNMT1.
Hypermethylation of genes involved in the cell cycle, DNA repair, angiogenesis, metabolism of carcinogens, apoptosis, and cell-cell interaction have been implicated in carcinogenesis. It should be noted that hypermethylation also occurs as a normal physiologic process, for example during inactivation of the second X chromosome (Barr body) in females. In addition, hypermethylation is a physiologic process associated with aging and methylation-induced transcriptional repression of repetitive DNA elements helps to prevent chromosomal instability.
In the laboratory, DNA methylation can be measured by many different methods in tissues, and occasionally in peripheral blood or other body secretions such as bile. One of the major advantages of attempting to detect methylation is the inherent stability of DNA. Before the advent of DNA methylation sequencing methods, isoschizomers with different methylation sensitivities were used to detect DNA methylation. A major disadvantage with this method is that less than 5% of the methylated cytosines can be assessed in any given DNA sequence. Since the early 1990s, a key method by which methylation levels are determined requires an initial bisufilte conversion of DNA. This bisulfite treatment converts unmethylated but not methylated cytosines to uracils. Subsequent gene-specific methylation can be determined by qualitative or quantitative methylation-specific PCR (MSP) using primers and probes specific to the corresponding methylated DNA sequence [11]. The advantages of MSP is that it gives a positive display of methylated cytosines and provides the entire profile of methylation for a defined DNA sequence rather than assessment of just a few cytosines within a sequence. Real-time quantitative MSP is preferred by the author, as it determines the actual percentage of methylated alleles in a given sample.
DNA sequencing can also be performed on bisulfite-converted DNA in order to determine specific regions of hyper- or hypomethylation. This is a particularly useful technique to determine regions of differential methylation, and aid in primer and probe design for the more specific MSP. Pyrosequencing is a method of real-time DNA sequencing that is based upon the activity of DNA polymerase and relies on the luminometric detection of pyrophosphate release after nucleotide incorporation [12]. An advantage of pyrosequencing is that it combines the high-throughput nature of PCR-based technologies with the ability to analyze all of the individual CpGs of a given region [12].
A limitation of the PCR-based technologies is that they specifically target candidate genes of interest. More recently, the development of high-throughput, genome-wide, microarray platforms have been developed in attempt to define the global methylation pattern of tumors. Methylated DNA immunoprecipitation (MeDIP) is an immunologic approach that enriches methylated DNA, and is based upon the principle that genomic DNA is randomly sheared by sonication and can be immunoprecipitated with an antibody that specifically targets 5-methylcytidine. This technique can be used to generate comprehensive, genomic DNA methylation profiles and to identify abnormally (hyper- or hypo-)methylated genes [13].
The methylated CpG island amplification (MCA) method is based on digestion of genomic DNA with the methylation-sensitive restriction enzyme, SmaI, which cuts only unmethylated sites, leaving blunt ends between the C and G. The DNA is then digested with the methylation-insensitive, SmaI isoschizomer, XmaI, which leaves a four-base overhang. These two serial digests are followed by ligation of adaptors to the overhang, and finally performing adaptor-specific PCR amplification [14]. Thus, this method results in the enrichment and amplification of methylated DNA fragments only. These methylated DNA fragments are then used for interrogations with microarrays platforms.
An additional method by which to discover novel targets of methylation-induced transcriptional silencing is to treat cancerous cell lines with agents that reverse epigenetic events, and then perform gene expression microarrays to determine which genes become upregulated.
Chromatin is comprised of histones and DNA. Histones are the protein components of chromatin, the structure around which DNA is wound. Histones are octomers with variable tails that extend out of the DNA/histone complex (nucleosome). There are several types of post-translational modification that can affect the histone tails, including methylation, acetylation, phosphorylation, and ubiquitination. These modifications can affect interactions between DNA and histones, leading to alterations in gene transcription, DNA repair, DNA replication, and even the organization of chromosomes [4].
One of the best studied histone modifications is the acetylation of the lysine residue. In general, histone acetylation is associated with transcriptional activation, and deacetylation is linked with transcriptional repression (fig. (fig.2).2). Acetylation neutralizes the positively charged lysine residue in the histone tail, reducing the strength of the bond between the histone tails and DNA. This phenomenon opens up the DNA/histone complex such that it is accessible to transcription factors [1]. Methylation of histones can positively or negatively affect transcription. Collaboration between DNA methylation and histone modifications may also occur. With the all the different modifications and combinations of alterations, the complexity of chromatin modifications is remarkable, and is still an area of intense investigation [15].
In the laboratory, histone modifications are readily and accurately detectable by mass spectrometry. However, this technique is laborious and requires highly specialized training and equipment [16]. In order to determine the true biological significance of histone modification, DNA sequence information is also required. The optimal technique, chromatin immunoprecipitation (ChIP), combines sequencing technology with DNA that has been immunoprecipitated with antibodies against specific histone modifications. Genome-wide studies of histone modifications are now possible through the use of so-called 'ChIP on chip' studies that couple immunoprecipitation with microarray sequencing platforms. Current limitations of this technique are the quality of the polyclonal antibodies engineered against the histone modifications [16].
Imprinted genes have mono-allelic expression – there is only 1 copy (from one of the parents) instead of 2. Approximately 1% of autosomal genes are imprinted. DNA methylation and histone acetylation marks the imprinted gene, and keeps the gene from being transcribed. Because expression is dependent upon only 1 parent, the expression in the current generation is dependent upon the environment in which the previous generation resided and any epigenetic marks that may have occurred [2]. Loss of imprinting means that there is either bi-allelic expression of the gene, or both copies are not expressed. The functional haploid state of these genes makes them exquisitely susceptible to further epigenetic alterations or mutations [3]. Several developmental disorders are associated with imprinted genes, such as Angelman syndrome, Prader-Willi syndrome, and Beckwith-Wiedemann syndrome. Based on a parent-of-origin pattern of inheritance, it is theorized that bipolar disorder, autism, schizophrenia, and Tourette's syndrome may also be associated with loss of imprinting [2].
The best studied non-coding RNA are microRNA (miRNA). These are approximately 22 nucleotide long sequences that are coded by long non-coding RNA or introns of genes. miRNA are transcribed in the nucleus and undergo several modifications prior to their maturation. miRNA can inhibit translation of mRNA into protein by two methods. If the miRNA is a direct sequence complement to the mRNA, then the miRNA binds to the mRNA and degrades it through actions of the RISC complex. If the miRNA is an imperfect match to the mRNA, then the miRNA partially binds to the 3′ end of the mRNA and prohibits the actions of transfer RNA [1]. MiRNA have been found to be abnormally expressed in a host of gastrointestinal disease, including inflammatory bowel disease [17,18], cholangiocarcinoma [19], esophageal adenocarcinoma [20], and hepatocellular carcinoma [5,15].
There is increasing evidence suggesting that environmental exposures early in development play a role in disease later in life. It is epigenetics that provides a plausible link between environmental exposures and disease risk [2]. Epigenetics may also explain how the risk of a certain disease is passed down through generations. A classic example of how environmental exposures can effect epigenetic change is the story of the agouti mouse. The murine agouti allele Avy has a transposable element (named IAP) upstream of its promoter, and can be regulated by DNA methylation. The wild-type a allele encodes brown coat color and the Avy allele encodes yellow coat color, obesity and diabetes. Under basal conditions, the agouti mouse displays a chimeric phenotype with mixed brown and yellow coat color. The natural methylation of the IAP element results in increasing brown coat color and lean body mass. In one experiment, a/a mothers were bred with a/Avy males, and supplemented with methyl donors betaine, choline, vitamin B12, and folate. The offspring of the supplemented mothers were more lean and had more brown in their coats. Furthermore, the IAP elements of the supplemented animals were found to have increased methylation than the offspring of the unsupplemented mothers [2]. This experiment showed that exposure in utero could affect the epigenetic status of the offspring, and affect the phenotype as well. This same research group was able to induce methylation of the IAP element with the plant estrogen genisten at similar doses to humans that consume soy-based diets. Remarkably, the genisten supplementation of the mothers protected the offspring from diabetes [2].
Another example of environmental exposure and its effect on epigenetics is the Dutch Winter Hunger Study of 1944–45. During this time in occupied Holland, the Dutch were under strict rations. The daily meals consisted of two potatoes, two slices of bread, and a piece of beetroot. Six decades later, when compared to their same sex siblings, the offspring descended from the pregnant mothers of the famine continued to have biallelic expression of the imprinted gene IGFR2 [2]. It is presumed that the folate deficiency incurred by the famine resulted in this phenomenon. Diets rich in processed foods, such as those enjoyed in the Western world, are thought to be deficient in folate, betaine, and choline, thus potentially predisposing humans to epigenetic abnormalities.
Numerous other environmental exposures have been linked with altering epigenetic patterns during a lifetime, and subsequent risk of disease. Specific examples include tobacco smoke, alcohol, viral hepatitis, industrial pollutants, and carbon emissions. One study looked at the methylation and histone modifications in monozygotic twins at different stages in life. Early in life, the epigenetic signatures are nearly identical. However, at age 50, dramatic differences were found, suggesting that environmental exposures altered the epigenome [3].
The epigenetic events that regulate gene expression have clearly emerged as a fundamental mechanism in developmental biology and in the pathogenesis of human disease. For example, multiple genes that affect numerous cellular pathways are silenced by hypermethylation in cancer, and studying these genes has increased our understanding of how cancer develops and progresses. A majority of studies, however, focus on methylation of a single gene or panel of genes, without detailed investigation of the functional relevance of the gene silencing. With the advent of genome-wide microarray platforms, the 'methylome' will be further defined. The molecular information gained from epigenetic studies, in conjunction with other genetic information, could be used to develop a novel classification system for tumors and diseases. This theoretical classification system could be designed to reflect so-called 'tumor biology' that could predict clinical outcomes such as overall prognosis, risk of recurrence after surgery, or response to chemotherapy.
Naturally, with the increased knowledge regarding the pathogenesis of disease, there is hope for the development of a new era of novel therapeutic agents that may effectively treat patients. The beauty of epigenitic modifications to DNA is that they are potentially preventable or even reversible. For example, blocking DNA methylation by inhibiting DNMTs results in demethylation of CpG islands in daughter cells, with subsequent restored expression of tumor suppressor genes and abrogation of tumor growth. There are several DNA demethylating compounds that are actively being investigated, including 5-azacytidine (AzaC), 5-aza-2′-deoxycytidine, zebularine, procainamide, and procaine [8]. Unfortunately, toxicity has been a major limiting feature of these medications, and they are currently only indicated in patients with advanced myelodysplastic syndromes [21]. Rather than systemically administered therapeutics, specialized delivery systems that specifically target aberrant methylation in tumors are actively being developed and studied. Abnormal promoter methylation has also been shown to correlate with chemotherapy and radiation resistance [22]. In the future, it is conceivable that demethylating agents could be used to enhance the effectiveness of traditional chemotherapy [21].
There are also a host of histone deacetylase (HDAC) inhibitors that are being studied for the treatment of cancer. Examples of these HDAC inhibitors include suberoylanilide hydroxamic acid, trichostatin A, valproic acid, and sodium butyrate [8]. These agents result in an increase of histone acetylation by blocking the action of multiple HDACs, and are commonly used in laboratory experiments to reverse epigenetic-induced gene silencing.
Many of the epigenetic events described have been detected in human samples in preneoplastic tissues. In particular, some hypermethylated genes may even be detected in the serum of patients prior to clinical detection of malignancy. Another example is the prediction of the development of dyplasia progression in Barrett's associated adenocarcinoma of the esophagus. In a randomized, double-blinded, multicenter study, a panel of eight hypermethylated genes predicted the progression of dyplasia better than traditional clinical risk factors [23]. For this reason, DNA methylation, hypomethylation, or histone modification are potential candidates for biomarkers for the early detection of disease.
In summary, epigentics has emerged as a crucial link between nature and nurture. With an incredible degree of complexity, epigenetic phenomena exert a profound influence on the regulation of how genetic information is transcribed and translated into proteins and phenotypes. With advanced technologies and knowledge, future discoveries regarding the pathogenesis of multifactorial and previously idiopathic diseases are possible.
The author declares that no financial or other conflict of interest exists in relation to the content of the article.
This work is supported by a K08DK083774 sponsored by the National Institutes of Diabetes and Digestive and Kidney Disorders Branch of the National Institutes of Health (USA).
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


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It was another programme much more explicit and defiant than the enchiridion had been.
Was there, then, any objection to his works: the enchiridion, the Adagia?
But the enchiridion was not the only work published by Erasmus during this interval.
The enchiridion was submitted to the judgment of Vitrarius, and obtained his approval.
The letter to Volzius just quoted was printed as a preface to a new edition of the enchiridion in 1518.
The above is an abridged translation from the enchiridion, ed.
enchiridion militis Christiani, printed in Lucubratiunculae, 1503.
The enchiridion is a summary of theoretical and applied Stoicism.
The enchiridion was the result, of which more will be said by and by.
enchiridion, en-ki-rid′i-on, n. a book to be carried in the hand for reference: a manual.


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Dr. Chams was fellowship trained at the prestigious Southern California Orthopedic Institute where he received specialized training in minimally invasive arthroscopic surgery of complex knee and shoulder issues and sports injuries. After his fellowship, he brought back many procedures that had not previously been performed in the area.
Dr Chams has been in practice with the Illinois Bone and Joint Institute for over 15 years. His Sports Medicine experience includes treating thousands of Professional, NCAA, Amateur athletes, as well as work related injuries. He has been the team physician for Lake Forest College as well as multiple High School teams and athletic clubs, for 15 years. He has been chosen as a team physician for the USA Soccer Federation Men and Women National Teams.
Dr. Chams has presented at national meetings, published multiple journal articles, instructional videos, and has authored a text book chapter on Advanced Shoulder Arthroscopy. He continues to be active as a member and instructor for the Arthroscopy Association of North America (AANA), American Association of Orthopedic Surgeons (AAOS), and the American Orthopedic Society for Sports Medicine (AOSSM), teaching advanced knee and shoulder arthroscopic surgical technique courses for other Orthopedic surgeons.
He is an instructor for the Residents / Fellows Advanced Surgical Arthroscopic Shoulder/ Knee Course at the Academy Learning Center and continues to routinely teach continued medical education courses for physicians, physical therapists, and athletic trainers.
Sports Medicine,
Workers Compensation
Arthroscopic Surgery & Reconstruction of the Knee and Shoulder,
Cartilage Restoration / Transplantation / Orthobiologics,
Orthopaedic Surgery - Adult and Pediatric Sports Medicine,
Platelet Rich Plasma Injections (PRP) / Musculoskeletal Ultrasound
Independent Practitioner
Orthopaedic Surgery
Orthopaedic Surgery
University of Illinois at Chicago, 1992
University of Illinois at Chicago, 1997


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The free agent outfielder came to terms late Thursday with the Cardinals in a move made by the club to replace some of Pujols' lost offense in their 2012 lineup. Ironically, both players are represented by agent Dan Lozano.
|Beltran was with the New York Mets from 2005-July 2011
In the final year of a seven-year, $119 million contract originally signed with the New York Mets in 2005, Beltran was dealt to the San Francisco Giants in July. The Cardinals will not forfeit their first-round draft pick in signing Beltran since his previous contract precluded the Giants from offering arbitration to the Type A free agent.
The 34-year-old switch-hitter has been one of the game's top offensive forces, but has been limited by problem knees in recent years.
Beltran had a cortisone shot in his left knee during 2011 spring training. It was suggested he may have aggravated it while compensating for his right knee.
Beltran's most recent move under the knife was surgery on his right knee in January 2010 to remove 20-30 loose particles. He wore a brace after his mid-season return and stopped playing in centerfield. The surgery decision caused controversy as the Mets originally were upset that Beltran had the procedure without their approval.
In the 2007-08 offseason, Beltran had surgery on both knees.
Beltran was able to play in just 145 games total over the 2009 and 2010 seasons before logging 142 this past season between the Mets and Giants. The 2011 National League All-Star hit 22 home runs and drove in 84, with a line of .300/.385/.525/.910.
Over his 14-year MLB career which began with Kansas City in 1998, Beltran has been an all-star six times. He has three Gold Glove Awards, two Silver Sluggers and was the 1999 American League Rookie of the Year.
Beltran is a career .283 hitter with 302 home runs and 1,146 RBI. His 302 home runs rank fourth among switch hitters from his first full season in the majors (1999) to present. Beltran has driven in over 100 RBI in a season seven times, most recently in 2008 with the Mets.
Beltran has appeared in the postseason twice, in 2004 with Houston and in 2006 with the Mets. In both of those years, Beltran and his team faced the Cardinals in the League Championship Series, with the Cardinals advancing to the World Series both times. In 2004, Beltran set numerous MLB postseason records including a record-tying eight home runs and a ML postseason record with a home run in five consecutive games (Game 5 of the NLDS through Game 4 of the NLCS).
The native of Puerto Rico resides in his home country in the off-season and played for Puerto Rico in the 2006 and 2009 World Baseball Classics.
With the 2012 Cardinals, Beltran will almost certainly begin the season in right field with Allen Craig perhaps out for at least a month recovering from knee surgery. It is unclear how much time Beltran can spend in centerfield because of his knees. Ideally, he would play there at least against left-handed pitching, with Jon Jay sitting.
With the move, the Cardinals will have 39 players on their 40-man roster. To see the 40-man, and the entire Cardinals minor league system by level and position, check out the Cardinals roster matrix at The Cardinal Nation Blog.
Brian Walton can be reached via email at firstname.lastname@example.com. Also catch his Cardinals commentary daily at The Cardinal Nation blog. Look for his weekly minor league column during the season at FOXSportsMidwest.com. Follow Brian on Twitter.
© 2011 The Cardinal Nation, thecardinalnation.com and stlcardinals.scout.com. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


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The 'Paper Planes' singer says in a video that the lawsuit launched by NFL bosses has 'been making me laugh for a while but now it's so boring I don't even laugh anymore.'
Singer M.I.A. has released a video statement following a $1.5 million lawsuit which was launched against her by National Football League. The singer, who is being sued for breach of contract because of middle finger gesture at the 2012 Super Bowl, defended herself in the 2-minute video, saying that the lawsuit is "ridiculous."
"The NFL thing is completely ridiculous. It's been making me laugh for a while but now it's so boring I don't even laugh anymore," she says in the video, which was released on September 23. In the video, the 38-year-old singer pointed out at cheerleaders at the event who posed provocatively.
"The precise moment in question... has my middle finger in the foreground and if you find the larger picture, where it zooms out, there is a row background scenery (sic) of 10, 15 cheerleaders, young black females that Madonna got from a local high school ... They were all under 16," she added. "If you look at them, they're wearing cheerleader outfits, hips thrust in the air, legs wide open in this very sexually provocative position."
"So now they've (NFL bosses) scapegoated me into figuring out the goalposts on what is offensive in America. Is my finger offensive, or is an underage black girl with her legs wide open more offensive to the family audience ... It's a massive waste of time, a massive waste of money, it's a massive display of a powerful corporation d**k shaking; they want me on my knees and to say sorry, so they can slap me on the wrist," she said again.


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A little discussion
A co worker and I had a discussion on the the way to work to day about CHL. Because I read on another thread here about some new proposed law here in Texas.
Here is a little back ground info on this guy he is very pro Second amendment.
He believes that making a person pay and sit in a class for 10 hr is against your second amendment right . Because they are infrining on our right. I said no the state just wants you to be trained and safe. And to make sure your not a crimanl.
What do you all think about this.
You're both right.
Hope this helps. ;)
I think a 10 hour class is the most absurd thing ever. Way overthetop, just like everything extremists do, libtards and conservatives alike.
Nope. I'm not a real firm believer in classes and waiting periods. I think they're great idea, and everyone should do it, but I don't think it should be a requirement. It IS an infringement if it's required.
I DO very firmly believe in harsher punishments for crimes committed and general dumbassery that results in injury or death.
"common sense" gun control (which is what you're suggesting) is all about control, and the "common sense" part is never the goal, nor usually even in the equation.
Now, killing murderers via hanging, the chair, or even lethal injection, plus those who kill accidentally through gross negligence, will do several things: take criminals off the streets-for good. And encourage know-nothings to become learn-somethings, in order to not become a death row statistic. This also applies to reckless/drunk driving, and pretty much any other death resulting from negligence.
I'm with trip on the "should it be required" thing. You should go to the class, but it shouldn't be a requirement.
I think a handgun safety class is important. Having it as a requirement, does infringe on 2A. But getting shot by an ND would upset me greatly.
I realize that a law abiding person should be able to just walk into a store buy a gun and put it in his pocket. That's how it used to be. Times are different and I don't really know what's right anymore. Maybe I'm brainwashed.
I believe there should be a class required for ccw. If I am stupid and shoot myself in my garage that is my problem. If I am stupid and shoot you by mistake at the mall...well that is another matter isn't it? I think a simple safety class should be sufficient.
How can that be solved? I don't know--
Well Hoss, what did you do to become experienced?
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Mentor Graphics released a new version of the Mentor Embedded Sourcery VSIPL++ tool. The newest enhancements to the Sourcery VSIPL++ product incorporates OMG's VSIPL++ specification standard. VSIPL++ is an important step forward for interoperable, portable, reusable applications in the high-performance computing space. The tool is ideal for developers working on compute-intensive applications.
Mentor Embedded Sourcery VSIPL++ includes support for ARM v7 Cortex A with NEON single instruction, multiple data (SIMD) processing platforms, and an interface to MATLAB for signal and image processing algorithm conversion. The MATLAB interface enables designers to easily convert algorithm models into VSIPL++ compliant C++ code and to verify the correct function of the deployed code on a specific target system.
The Sourcery VSIPL++ tool is an open standard, high-level C++ image and signal processing library for high performance computing (HPC) applications. The Mentor product enables engineers to express algorithms in high-level C++ code, to improve application speed performance and software development productivity for signal and image processing algorithms used in embedded systems while simultaneously ensuring application portability across a wide variety of compute platforms.
Mentor Embedded Sourcery VSIPL++ tool is ideal for radar for military-aerospace, medical diagnostic imaging, and computer vision applications for industrial control and automotive markets.
More info: Mentor Embedded Sourcery VSIPL++


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Are you or a family member 55+ or a member of AARP? If so, make sure you shop at Walgreens on Tuesday, February 2nd. If you qualify (AARP or 55+), you will save 20% on regular price merchandise.
Hopefully we can put together some nice scenarios that include the regular price items but earn points or Register Rewards.Extreme Couponing Tip: You can usually get two prints of most internet coupons. To find them in the easiest possible way, use our preclipped links that take you right to the coupon. Then come back and click the same link to get your 2nd print. This will save you the time spent searching for the coupon.
Never miss another hot coupon, deal or freebie again! "Like" Couponaholic .NET on Facebook, Follow us on Pinterest, Follow us on Twitter, Follow us on Instagram or Subscribe to our Daily Email Newsletter!


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Eve Online is insane and scary
And so are the people who play it.But we still need a place to relax and discuss our hopes, dreams, and acts of horrific piracy. Same difference? I haven't been playing Eve Online very long, only a couple of weeks in-fact, but I still think there should be at least one thread on Giantbomb where Eve Online players can congregate.
I'm currently sitting on my first million skillpoints with a Caracal fit with 4 Heavy Launchers and a Salvager, just scooting around doing some missions for the Caladari Navy. If you had asked me a week ago what any of those words meant I would have been completely baffled, but it's amazing how fast you pick stuff up.
I'm still rockin' this noob corp, mainly because they are patient enough to put up with my idiot questions, but I want to go into covert ops - appreciated that will probably take me the best part of a year but i'm GOING TO MAKE THIS SHIT WORK.
My housemate just started playing as well, he spends all his time exploring wormholes, a section of the game I didn't even know existed. (In-your-endo?)
Anyways, feel free to share and ask questions.
EDIT: My character name is SWEEP XXII, look me up ingame if you need someone to fire missiles at stuff.


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Project DescriptionSite A bluff in Minnesota overlooking a broad valley and 40 acres of restored native prairie.
Program A nondenominational chapel.
Solution On private land, but open to the public, the 588-square-foot Prairie Chapel designed by Venice, Calif.–based Hughesumbanhowar Architects is formed from weathered, corrugated metal panels and wood recycled from an old Quonset hut that served the farm for 60 years. Reclaimed trusses are shaped and connected with metal plates to produce new composite-curved frames separated by a continuous slot that moves down from the roof to ground level to become the entrance. The resulting form is pinched, twisted, and sliced, resulting in a volume that mimics weathered boulders found on the site. Jurors praised the economical use of materials—interior walls are clad in slats of flamed, recycled cedar—and the spiritual qualities of the space. "I appreciated the simplicity and … [the way] the interiors are developed in conjunction with the exterior," said juror Ann Beha. "That makes it a more thorough and integrated project."