text:
Two incumbents are seeking to keep their seats on the Sunnyside Unified School District Governing Board in a race that has four candidates vying for three seats.
One of those seats is vacant, since former board president Magdalena Barajas resigned in June to attend New York University to pursue graduate studies.
Buck Crouch, the current board president, was appointed in August 2011 to fill the seat left vacant by Robert Jaramillo, who resigned to teach at Desert View High School.
Besides Crouch, the other incumbent is Louie Gonzales, who was appointed to the board in 2007 and elected in 2008. He previously served from 1990 to 1996.
Newcomers Robert "Bobby" Garcia, a retired Tucson Police Department officer, and Malcom R. Pavey, a self-employed academic assessor and tutor, are campaigning for a seat.
The top three vote-getters in the Nov. 6 election will be seated on the board.
The district is also asking voters to approve a 15 percent maintenance and operations budget override.
During the past four years, the maintenance and operations budget has been cut by more than $13 million, said Hector M. Encinas, the district's chief financial officer. Eighty-five percent of this budget goes for employees' pay and benefits.
Last year, voters approved an $88 million bond issue for the district, but turned down a 10 percent maintenance and operations budget override. If the override is not approved, Encinas predicts staff and program cuts.
The district's budget is $143.7 million and at the start of the school year it had 17,311 students. It has 22 schools and 2,145 employees.
Following are the candidates' views on what each sees as the top issue facing the district:
• Crouch said state cuts in education are hurting students and society. He said he supports the budget override and that if it fails the district faces "deep cuts" in programs.
• Gonzales said the district needs to graduate students who are prepared for unlimited choices. He said he favors early-childhood education, laptops for all students and increasing graduation rates.
• Pavey said the board needs to make "tough, frugal, conscious and prudent decisions" on the budget to "best meet the needs of the students," including preparing graduates for college or the workforce.
• Garcia said the board needs to get a better handle on the budget and improve employees' benefits and salaries.
On Starnet
Visit azstarnet.com/elections to find more coverage and election resources, including:
• Which federal, state, county and school board seats are up for grabs in this election cycle.
• Candidates: bio info and answers to the Star's candidate questionnaire.
• Information about the ballot propositions.
• Voter resources: maps of the redrawn legislative and congressional districts; where to vote.
• Links to recent coverage of local, state and national politics.
• Fun election-themed interactives.
• Updated vote totals on election night.
Contact reporter Carmen Duarte at email@example.com or 573-4104.


text:
"There was one more thing: I learned that I have to be myself. I always have to be me… From the moment that a fight ends, that fight is in the past, win or lose. Even when I was winning my fights, once it's over, it's over. It's in the past, and you've got to look forward. It's no different with this fight. When it was over, it was over, and now I'm looking forward to the next one. It's definitely a big fight. It's an important fight. It's something people have been waiting to watch. They want confirmation that Chris is the real deal. But a fight is a fight. All that changes is the date and the opponent. The octagon is still the same, and the atmosphere is always the same. I don't think I have anything to prove to anyone, but I'm very motivated."
Often criticized for the way he toys with his foe's inside the cage, Anderson Silva tells MMaJunkie.com during this week's UFC 168 media event that he has to stay true to himself, even if that means going against his critics wishes.Tags: Anderson Silva, Chris Leben, Chris Weidman, Josh Barnett, miesha tate, mma, MMA NEWS. Silva vs. Weidman, Ronda Rousey, silva vs weidman 2, tate vs rousey, tate vs rousey 2, travis browne, ufc, UFC 168, ufc news, uriah hall, Vitor Belfort

subset: commoncrawl


text:
This is not a love story. But, if you want to find...
Mon capitaine,mon capitaine
- by TFALokiwriter
- Rating:
- Published: 10 Nov 2015
- Updated: 10 Nov 2015
- Status: Complete
This story is told through the perspective of Q, the omnipotent being. Q has a conflict with a M. This conflict leads to the death of someone very important and close to Q. So because of that, Q goes back in time. Started: 8.25.2015. Completed: 8. 25.2015 at 4:31 PM. First story where the name 'Quarty' is used.
Join MovellasFind out what all the buzz is about. Join now to start sharing your creativity and passion
Loading ...


text:
Learning In Motion Preschool, Inc. ©
10945 Stirling Road, Cooper City, FL 33328
License 46480
Welcome to Learning in Motion Preschool!
Please enjoy our website and we would like to extend an open invitation for a personal tour of our school.
Learning in Motion is Accredited by the Association for Early Learning Centers
Committed to Excellence!
There are only a few openings remaining in our fall VPK class.
Click below for details!
Message Board


text: You know, sometimes the hardest part of a stripping job is getting that residual stripper and old paint out of the details, like the panel here in this old door. Well, here are three tips that'll make that go easier. Tip Number One: use a small bristled brass brush like this to get up inside these crevices and scrub out that leftover stripper. Now, you want to use a brass bristle brush because the brass bristles are softer and won't scratch the wood. Idea Number Two: take a piece of dowel, put it in a pencil sharpener and put a point on it, just like this one, and use that to get into those hard-to-reach spaces and to get out that nasty stuff. And Tip Number Three: take some kitty litter - that's right, kitty litter - and sprinkle it on the excess stripper that may've been left behind. It's very absorbent. If you just move it around with your hands like this, it'll pick up all that extra material and then all you have to do is either brush or vacuum it off. Now, what could be easier than that?


text: Montana-Dakota Utilities Co., a division of MDU Resources Group, Inc. (NYSE:MDU), announced today that it has signed a power purchase agreement with Thunder Spirit Wind LLC, a subsidiary of Wind Works Power Corp. The agreement is for approximately 105 megawatts of installed capacity of wind turbine generators to be located in southwest North Dakota near Hettinger. The generation will interconnect at Montana-Dakota's substation near Hettinger. The project is expected to begin commercial operation in the fourth quarter of 2015. Montana-Dakota issued a request for proposal earlier this year for electric capacity and energy. The Thunder Spirit Wind proposal will provide Montana-Dakota customers with stable pricing over the 25-year contract. "This is a competitively priced agreement that will serve our customers for many years to come," said K. Frank Morehouse, president and CEO of Montana-Dakota Utilities. "Moving some of our current market energy purchases into a fixed contract helps protect our customers from unexpected changes in market pricing." In addition to renewable generation owned by Montana-Dakota, the agreement with Thunder Spirit Wind means 20 percent of Montana-Dakota's energy supply requirements will come from renewable resources. Montana-Dakota Utilities Co. distributes natural gas and generates, transmits and distributes electricity and provides related services in the northern Great Plains. The company serves approximately 135,000 electric customers and 245,000 natural gas customers in 262 communities in North Dakota, South Dakota, Montana and Wyoming. Montana-Dakota is a division of MDU Resources Group, Inc., a diversified natural resources company traded on the New York Stock Exchange as "MDU." For more information about MDU Resources, visit the company's Web site at www.mdu.com . For more information about Montana-Dakota, visit www.montana-dakota.com .


text:
Borjhar, Jan. 5: Two foreign nationals brought stark reality on rhino protection to the fore at Chandubi Festival.
It is dangerous to use the sidewalks of Guwahati as there are potholes everywhere. If a government cannot take care of its people, how can it protect the flora and fauna of the state? asked Gilad Ekerman, 24, a nature activist from Israel, referring to the increasing number of rhino deaths in Assam.
Forty-one rhinos were killed in the state last year.
Ekerman was accompanied by his friend and fellow activist Pawel, 26, from Poland to the festival that concluded today.
Spellbound by the serene, secluded and solitary environment of the Chandubi lake, the activists said the main attraction of Assam is the Kaziranga National Park. The duo had visited the park in December.
It (rhino poaching) is a horrible crime and failure to put an end to it is not only a matter of grave concern but substantiates the fact that the government has not been able to rise to the occasion to protect this prized possession of the planet, echoed Pawel.
The elephant safari at the park also drew flak from the two.
Elephants should not be used for safaris. Putting the gentle giants into service for entertainment is not right. This is my view although I do not want to impose my opinion on anyone, Gilad told this correspondent today.
According to them, not need but insatiable human greed is taking a toll on nature.
It is important to leave nature as it is. At the same time I would appeal to picnickers for an eco-friendly celebration and to keep the flora and fauna undisturbed, the Israeli said.
On a humble mission to create mass awareness among the people, the foreign nationals were fascinated by the artistic application of bamboo to make shelters, gates and a material to serve food at the winter festival.
Bamboo as a construction material is an ideal substitute for wood, and if used properly, the pressure on the forest landscape will be reduced, Pawel said.
At the five-day winter festival, Gilad and Pawel also tasted the ethnic food items like ketli pith, sunga pitha and others.
On a six-month visa, the duo are also here to participate in the Dancing Rain Creative Festival, scheduled to be held on January 18 and 19 at Kazalichaki village near Pobitora wildlife sanctuary.
Tourists Tamara Artajeva, 25, from Lithuania and Craig Winzelberg, 51, from the US, will also accompany them to the festival.
The Dancing Rain Creative Festival is being organised by Alak Jyoti Pathak, a sculptor. Pathak and his group work for the preservation of nature, art and culture under the banner of Paribartan, an NGO.


text:
CASANFRA-L ArchivesArchiver > CASANFRA > 1999-08 > 0935983949
From: <>
Subject: [CASANFRA] Re: CASANFRA-D Digest V99 #196
Date: Sun, 29 Aug 1999 23:32:29 EDT
In 1985 I wrote to the San Francisco Police Department, Historical Archives
Information, 850 Bryant St., San Francisco, CA 94103 in regards to an early
Department member. My letter was answered by Officer Robert Fitzer,
Historian, San Francisco PD. I'm sure he probably still isn't the Historian,
but a letter to the above address would probably get you a reply.
Marj Meagher
In a message dated 08/29/1999 2:20:14 AM Pacific Daylight Time,
> From:
> To:
> Subject: [CASANFRA] S.F.Police Dept.
> Can anyone please tell me if the S.F.Police Dept. has a Historian, and how
> can get in touch with him/her? Thank you very much. Delbert T Greer at the
> cross roads, they call it Dublin Ca.
This thread:


text:
FLORENCE, S.C. – The Francis Marion University women's softball team will host a pair of non-conference doubleheaders this weekend.
The Patriots (15-7) will entertain Kutztown University (7-5) on Saturday at 1 p.m., and local-rival Coker College (18-7), Sunday at 1 p.m. Both twinbills will be played on the FMU Softball Field and admission is free.
Freshman lead-off batter Shannan Tyson leads FMU with a .387 average, while sophomore shortstop Allie Aleman is hitting .329 with four home runs and a team-leading 19 runs batted in.
The Patriot pitching staff is anchored by junior right-hander Jessica Johnson with an 8-3 record and a 1.95 earned run average, while freshman righty Serena Lim is 6-4 with a 2.07 ERA.
FMU trails in the all-time series with Coker 25-20, but the Patriots have won six of the last eight meetings. Francis Marion and Kutztown have met only once before with the Patriots claiming a 4-2 win in 1996.


text:
Gene name - nejire
Synonyms - CREB-binding protein - CBP
Cytological map position - 8F--9A
Function - transcriptional coactivator
Keywords - chromatin modification, histone acetyltransferase
Symbol - nej
FlyBase ID: FBgn0261617
Genetic map position -
Classification - CREB-binding protein
Cellular location - nuclear
|Recent literature
|Cutler, T., Sarkar, A., Moran, M., Steffensmeier, A., Puli, O. R., Mancini, G., Tare, M., Gogia, N. and Singh, A. (2015). Drosophila eye model to study neuroprotective role of CREB binding protein (CBP) in Alzheimer's disease. PLoS One 10: e0137691. PubMed ID: 26367392
This study utilized Gal4/UAS system to develop a transgenic fruit fly model for Aβ42 (see Drosophila Appl) mediated neurodegeneration. Targeted misexpression of human Aβ42 in the differentiating photoreceptor neurons of the developing eye of transgenic fly triggers neurodegeneration. This progressive neurodegenerative phenotype resembles Alzheimer's like neuropathology. A histone acetylase, CREB Binding Protein (CBP), was identified as a genetic modifier of Aβ42 mediated neurodegeneration. Targeted misexpression of CBP along with Aβ42 in the differentiating retina can significantly rescue neurodegeneration. Gain-of-function of CBP rescues Aβ42 mediated neurodegeneration by blocking cell death. Misexpression of Aβ42 affects the targeting of axons from retina to the brain but misexpression of full length CBP along with Aβ42 can restore this defect. The CBP protein has multiple domains and is known to interact with many different proteins. This structure function analysis using truncated constructs lacking one or more domains of CBP protein, in transgenic flies revealed that Bromo, HAT and polyglutamine (BHQ) domains together are required for the neuroprotective function of CBP. This BHQ domain of CBP has not been attributed to promote survival in any other neurodegenerative disorders. This study has identified CBP as a genetic modifier of Aβ42 mediated neurodegeneration. Furthermore, this study had identified BHQ domain of CBP is being responsible for its neuroprotective function. These studies may have significant bearing on understanding of genetic basis of AD.
|Philip, P., Boija, A., Vaid, R., Churcher, A. M., Meyers, D. J., Cole, P. A., Mannervik, M. and Stenberg, P. (2015). CBP binding outside of promoters and enhancers in Drosophila melanogaster. Epigenetics Chromatin 8: 48. PubMed ID: 26604986
CREB-binding protein (CBP, also known as nejire) is a transcriptional co-activator that is conserved in metazoans. CBP and the related p300 protein have been used to predict enhancers when they occur with monomethylation of histone H3 on lysine 4 (H3K4me1). This study shows that CBP is bound at genomic sites with a wide range of functions. As expected, CBP was bound at active promoters and enhancers. In addition, the strongest CBP sites in the genome were found at Polycomb response elements embedded in histone H3 lysine 27 trimethylated (H3K27me3) chromatin, where they correlate with binding of the Pho repressive complex. CBP also binds to most insulators in the genome. At a subset of these, CBP may regulate insulating activity, measured as the ability to prevent repressive H3K27 methylation from spreading into adjacent chromatin. It is concluded that CBP could be involved Polycomb repression and insulator activity. A CBP at all functional elements may be to regulate interactions between distant chromosomal regions, and it is speculated that CBP is controlling higher order chromatin organization.
|Fernandez-Nicolas, A. and Belles, X. (2015). CREB-binding protein contributes to the regulation of endocrine and developmental pathways in insect hemimetabolan pre-metamorphosis. Biochim Biophys Acta 860(3):508-15. PubMed ID: 26706852
CREB-binding protein (CBP) is a promiscuous transcriptional co-regulator. In insects, CBP has been studied in the fly Drosophila melanogaster, where it is known as Nejire. Studies in D. melanogaster have revealed that Nejire is involved in the regulation of many pathways during embryo development, especially in anterior/posterior polarity, through Hedgehog and Wingless signaling, and in dorsal/ventral patterning, through TGF-β signaling. Regarding post-embryonic development, Nejire influences histone acetyl transferase activity on the ecdysone signaling pathway. Functional genomics studies using RNAi have shown that CBP contributes to the regulation of feeding and ecdysis during the pre-metamorphic nymphal instar of the cockroach Blattella germanica and is involved in TGF-β, ecdysone, and MEKRE93 pathways, contributing to the activation of Kr-h1 and E93 expression. In D. melanogaster, Nejire's involvement in the ecdysone pathway in pre-metamorphic stages is conserved, whereas the TGF-β pathway has only been described in the embryo. CBP role in ecdysis pathway and in the activation of Kr-h1 and E93 expression is described in this study for the first time. It is concluded that studies in D. melanogaster may have been suggestive that CBP functions in insects are concentrated in the embryo. Results obtained in B. germanica indicate, however, that CBP have diverse and important functions in post-embryonic development and metamorphosis, especially regarding endocrine signaling. Further research into a higher diversity of models will probably reveal that the multiple post-embryonic roles of CBP observed in B. germanica are general in insects.
Tie, F., Banerjee, R., Fu, C., Stratton, C.A., Fang, M. and Harte, P.J. (2016). Polycomb inhibits histone acetylation by CBP by binding directly to its catalytic domain. Proc Natl Acad Sci U S A [Epub ahead of print]. PubMed ID: 26802126
Drosophila Polycomb (PC), a subunit of Polycomb repressive complex 1 (PRC1), is well known for its role in maintaining repression of the homeotic genes and many others and for its binding to trimethylated histone H3 on Lys 27 (H3K27me3) via its chromodomain. This study identifies a novel activity of PC: inhibition of the histone acetylation activity of CREB-binding protein (CBP). It was shown that PC and its mammalian CBX orthologs interact directly with the histone acetyltransferase (HAT) domain of CBP, binding to the previously identified autoregulatory loop, whose autoacetylation greatly enhances HAT activity. A conserved PC motif adjacent to the chromodomain required for CBP binding was identified and it was shown that PC binding inhibits acetylation of histone H3. CBP autoacetylation impairs PC binding in vitro, and PC is preferentially associated with unacetylated CBP in vivo. PC knockdown elevates the acetylated H3K27 (H3K27ac) level globally and at promoter regions of some genes that are bound by both PC and CBP. Conversely, PC overexpression decreases the H3K27ac level in vivo and also suppresses CBP-dependent Polycomb phenotypes caused by overexpression of Trithorax, an antagonist of Polycomb silencing. It was found that PC physically associates with the initiating form of RNA polymerase II (Pol II) and many promoters co-occupied by PC and CBP are associated with paused Pol II, suggesting that PC may play a role in Pol II pausing. These results suggest that PC/PRC1 inhibition of CBP HAT activity plays a role in regulating transcription of both repressed and active PC-regulated genes.
|Sharma, S., Poetz, F., Bruer, M., Ly-Hartig, T. B., Schott, J., Seraphin, B. and Stoecklin, G. (2016). Acetylation-dependent control of global poly(A) RNA degradation by CBP/p300 and HDAC1/2. Mol Cell 63: 927-938. PubMed ID: 27635759
Acetylation of histones and transcription-related factors is known to exert epigenetic and transcriptional control of gene expression. This study reports that histone acetyltransferases (HATs) and histone deacetylases (HDACs) also regulate gene expression at the posttranscriptional level by controlling poly(A) RNA stability. Inhibition of HDAC1 and HDAC2 induces massive and widespread degradation of normally stable poly(A) RNA in mammalian and Drosophila cells. Acetylation-induced RNA decay depends on the HATs p300 and CBP, which acetylate the exoribonuclease CAF1a, a catalytic subunit of the CCR4-CAF1-NOT deadenlyase complex and thereby contribute to accelerating poly(A) RNA degradation. Taking adipocyte differentiation as a model, global stabilization of poly(A) RNA was observed during differentiation, concomitant with loss of CBP/p300 expression. This study uncovers reversible acetylation as a fundamental switch by which HATs and HDACs control the overall turnover of poly(A) RNA.
|Ghezzi, A., Li, X., Lew, L. K., Wijesekera, T. P. and Atkinson, N. S. (2017). Alcohol-induced neuroadaptation is orchestrated by the histone acetyltransferase CBP. Front Mol Neurosci 10: 103 [Epub ahead of print]. PubMed ID: 28442993
Homeostatic neural adaptations to alcohol underlie the production of alcohol tolerance and the associated symptoms of withdrawal. These adaptations have been shown to persist for relatively long periods of time and are believed to be of central importance in promoting the addictive state. In Drosophila, a single exposure to alcohol results in long-lasting alcohol tolerance and symptoms of withdrawal following alcohol clearance. These persistent adaptations involve mechanisms such as long-lasting changes in gene expression and perhaps epigenetic restructuring of chromosomal regions. Histone modifications have emerged as important modulators of gene expression and are thought to orchestrate and maintain the expression of multi-gene networks. Previously genes that contribute to tolerance were identified as those that show alcohol-induced changes in histone H4 acetylation following a single alcohol exposure. However, the molecular mediator of the acetylation process that orchestrates their expression remains unknown. This study shows that the Drosophila ortholog of mammalian CBP, nejire, is the histone acetyltransferase involved in regulatory changes producing tolerance-alcohol induces nejire expression, nejire mutations suppress tolerance, and transgenic nejire induction mimics tolerance in alcohol-naive animals. Moreover, a loss-of-function mutation in the alcohol tolerance gene slo epistatically suppresses the effects of CBP induction on alcohol resistance, linking nejire to a well-established alcohol tolerance gene network. It is proposed that CBP is a central regulator of the network of genes underlying an alcohol adaptation.
CREB-binding protein or CBP (in Drosophila, the protein termed Nejire) is a transcriptional coactivator that interacts with a large number of developmentally important transcription factors. CBP and p300 are highly related proteins: mammalian CBP was originally identified by its interaction with CREB (cAMP response-element-binding protein) and p300 was originally identified as a target of the adenoviral E1A oncoprotein. CBP is recruited to DNA by several transcription factors, including CREB (Drosophila homolog: CrebB-17A) and cFos (Drosophila homolog: Fos-related antigen/Kayak). Transcriptional coactivators are considered to be accessory proteins that interact with transcription factors and are required for proper transcription factor function.
Since inactivation of only a single copy of CBP causes severe developmental defects in Rubenstein-Taybi syndrome (Petrij, 1995), it has been proposed that CBP is a limiting integrator of multiple signal transduction pathways at the level of gene activation. Recently, CBP/p300 were reported to have intrinsic histone acetyltransferase (HAT) activity (Ogryzko, 1996 and Bannister, 1996). The identification in Tetrahymena of the first transcription-associated HAT has allowed a major advance in understanding the connection between histone acetylation and gene transcription. HAT has been found to share significant homology to the Saccharomyces cerevisiae adapter GCN5 (Brownell, 1996). GCN5 acetylates specific lysines in a pattern associated with transcriptionally active chromatin, and HAT activity is required for the activation of GCN5-responsive genes. These observations establish the causal link between histone acetyltransferase activity and activation of transcription. HAT activity displayed by multiple families of proteins is associated with gene activation through the modification of chromatin structure. PCAF, a mammalian homolog of GCN5, and CBP are found in a complex with a third family of HATs, the hormone receptor coactivators SRC and ACTR (Chen, 1997 and Spencer, 1997). Importantly, the in vitro substrate specificity of each of these HATs is distinct, suggesting that multiple HATs can act in concert at or near single promoters.
Drosophila CBP was isolated by screening Drosophila libraries under low-stringency hybridization conditions with a C. elegans CBP probe. The hemizygous nej mutant embryos die at stage 9 or 10 during embryogenesis, although some embryos survive to hatching. The most severe phenotype in nef hemizygotes is the twisting of the embryo that occurs at germband elongation.
Drosophila CBP is a coactivator of Cubitus interruptus in Hedgehog signaling. Ci is a known target of the Hh signal transduction pathway; in turn, Ci targets wingless. The expression of wingless is strikingly reduced at the posterior margin of each parasegment in CBP mutants. In addition, engrailed expression, which is maintained by Wg protein, is significantly lower in such mutants than in wild type. These observations suggest the Drosophila CBP might contribute to the functioning of some transcription factors involved in the activation of the Wingless-Engrailed signaling pathway. Ci protein physically interacts with Drosophila CBP. A series of deletion mutants of ci indicates that a region of Ci between amino acids 1020 and 1160 is required for a phosphorylation independent interaction with Drosophila CBP. This region is part of the Ci transactivation domain, C-terminal to five putative Protein kinase A (PKA) sites. Drosophila CBP expression augments transactivation by CI up to a maximum of 62 fold. The dominant gain-of-function ciD mutant phenotype, in which the longitudinal vein 4 of the adult wing is shortened, some posterior row hairs are missing, and the posterior wing margin is flattened, can be explained by the inappropriate expression of ci in the posterior compartment of the wing imaginal disc, where it is usually repressed by Engrailed. A subset of the ciD wing defects is suppressed by the haploinsufficiency of Drosophila CBP. Thus Drosophila CBP is required for the activation of Cubitus interruptus target genes such as patched, and CBP is required for the activator function of Ci but not for the repressor function. Drosophila CBP binds to dCREB2, the Drosophila homolog of CREB, in a phosphorylation-dependent manner, whereas the CBP-Ci interaction is phosphorylation-independent (Akimaru, 1997a).
These observations have been used to explain how two pathways can interfere with each other. PKA phosphorylates dCREB2 and this signaling function appears to repress Hh target genes such as dpp. Since Drosophila CBP binds to dCREB2 in a phosphorylation dependent manner, a limited amount of Drosophila CBP might be recruited to PKA-phosphorylated dCREB2, resulting in a decrease in Ci activity due to a diminished availability of Drosophila CBP. Therefore, a limited amount of Drosophila CBP might be recruited to PKA-phosphorylated dCREB2, resulting in a decrease in Ci activity, explaining the antagonistic actions of PKA and Hedgehog (Akimaru, 1997a).
The role of Drosophila CBP in the regulation of Hh target genes fails to explain the primary developmental effect of Drosophila CBP mutation observed at germband elongation: the clockwise or counter-clockwise twisting of the embryo, just behind the cephalic furrow, often with the posterior side down. The ventral and cephalic furrows appear normal, but the mesodermally derived internal tissues and a block of ectodermal cells are often missing. On the basis of this phenotype, the Drosophila CBP mutant was named nejire, which means 'twist' in Japanese. Mesoderm formation is crucial event that takes place during early embryogenesis. To initiate the differentiation of the mesoderm in Drosophila, multiple zygotic genes such as twist (twi) and snail (sna), which encode a basic-helix-loop-helix and a zinc finger transcription factor, respectively, are required. The transcription of these genes is induced by maternal Dorsal protein, a transcription factor involved in establishment of dorsal-ventral polarity, that is homologous to the NF-kappa B family of proteins. Drosophila CBP mutants, devoid of both maternal and zygotic nejire expression, fail to express twi and therefore generate twisted embryos. This is explained by results showing that dCBP is necessary for Dorsal-mediated activation of the twi promoter. In vitro Dorsal has been shown to bind the N-proximal portion of Drosophila CBP in a phosphorylation independent manner. A region of Dorsal lying between amino acids 186 and 356 (a part of the Rel homology domain) is required for interaction with CBP. Further studies indicated that a CBP-Dorsal complex is formed on the twist promoter (Akimaru, 1997b).
CBP not only exerts an effect on DNA transcription by acting as a histone transacetylase, but it can also acetylate transcription factors. In addition CBP can exert an inhibitory effect on transcription. The interaction of Drosophila CBP with Pangolin demonstrates both these points. T-cell factor (TCF), a high-mobility-group domain protein, is the transcription factor activated by Wnt/Wingless signaling. When signaling occurs, TCF binds to its coactivator, beta-catenin/Armadillo, and stimulates the transcription of the target genes of Wnt/Wingless by binding to TCF-responsive enhancers. Inappropriate activation of TCF in the colon epithelium and other cells leads to cancer. It is therefore desirable for unstimulated cells to have a negative control mechanism to keep TCF inactive. Drosophila CREB-binding protein binds to Drosophila TCF (Pangolin). dCBP mutants show mild Wingless overactivation phenotypes in various tissues. Consistent with this, Drosophila CBP loss-of-function suppresses the effects of armadillo mutation. Moreover, Drosophila CBP is shown to acetylate a conserved lysine in the Armadillo-binding domain of Pangolin, and this acetylation lowers the affinity of Armadillo binding to Pangolin. Although CBP is a coactivator of other transcription factors, these data show that CBP represses TCF. Indeed, point mutations have been found in the HAT and CBP2 domains of the remaining p300 gene in colon and gastric carcinomas that have lost one copy of this gene, indicating that p300/CBP has a tumor-suppressor function (Muraoka, 1996). This is consistent with data showing the Drosophila CBP represses Pangolin to antagonize Armadillo-mediated activation of Wingless target genes (Waltzer, 1998).
The conserved Notch pathway functions in diverse developmental and disease-related processes, requiring mechanisms to ensure appropriate target selection and gene activation in each context. To investigate the influence of chromatin organisation and dynamics on the response to Notch signalling, this study partitioned Drosophila chromatin using histone modifications and established the preferred chromatin conditions for binding of Su(H), the Notch pathway transcription factor. Manipulating activity of a co-operating factor, Lozenge/Runx, showed that it can help facilitate these conditions. While many histone modifications were unchanged by Su(H) binding or Notch activation, rapid changes were detected in acetylation of H3K56 at Notch-regulated enhancers. This modification extended over large regions, required the histone acetyl-transferase CBP and was independent of transcription. Such rapid changes in H3K56 acetylation appear to be a conserved indicator of enhancer activation as they also occurred at the mammalian Notch-regulated Hey1 gene and at Drosophila ecdysone-regulated genes. This intriguing example of a core histone modification increasing over short timescales may therefore underpin changes in chromatin accessibility needed to promote transcription following signalling activation (Skalska, 2015).
Signalling pathways such as Notch have diverse functions depending on the context in which they are activated and on the specific subsets of genes that are regulated in each context. This specificity necessitates mechanisms that enable Su(H) to recognise and bind to appropriate enhancers and effect relevant gene expression changes. By utilising the comprehensive collection of chromatin modifications gathered by the modENCODE project, this study has generated maps of chromatin states (see The full list of signal tracks) in two Drosophila cell types and related those to the loci that are bound by Su(H). In doing so, the profile of H3K56ac across the genome was also analysed, and that this core histone modification was found to be present at enhancers, and at transcription start sites, similar to the reported distribution in mammalian ES cells. Significantly, the inclusion of H3K56ac-binding data in the computational model helped to discriminate the active enhancers. Even more striking was the robust increase in this core nucleosome modification in response to Notch activation. Such changes were also detected in mammalian cells and at ecdysone-regulated genes in Drosophila, arguing that H3K56ac is likely to be a widespread modification associated with enhancer activation (Skalska, 2015).
Unlike the modifications to exposed histone tails, which primarily provide docking sites for further chromatin modifying proteins, H3K56ac can directly alter nucleosomal DNA accessibility by increasing DNA breathing and unwrapping rate. As a consequence, this modification can influence transcription factor (TF) occupancy within the nucleosome and it has been argued that H3K56ac drives chromatin towards the disassembled state during transcriptional activation. As the increase in H3K56ac appears to precede transcription elongation, it fits with the latter model. Furthermore, as mammalian CSL has been found to bind preferentially to motifs at the nucleosome exit point\, H3K56ac may enhance recruitment, giving a feed-forward benefit that could potentially explain the increase in occupancy following Notch activation. In addition, H3K56ac facilitates divergent transcription by promoting rapid nucleosome turnover and also promotes small RNA production in neurospora, which is consistent with the detection of intergenic enhancer-templated RNAs in the modified regions following Notch activation (Skalska, 2015).
The increase in H3K56ac appears to require CBP-HAT activity, which is also essential for catalysing this modification on free histones. It is plausible therefore that the increase in H3K56ac could occur through the incorporation of pre-modified nucleosomes. The modification of histone dimers requires interaction with the chaperones CAF1 and ASF1, and while genetic evidence that the chaperone subunit dCAF-1-p105 can help promote Notch signalling favours such a model, the current results suggest this is less likely. First, it was found that CBP is required at the time of activation, making it improbable that the increase in H3K56ac is a consequence of loading pre-modified histones. Second, an inhibitor of the CBP bromodomain, which plays an important role in enabling H3K56ac on histone dimers via its interaction with chaperones, had no effect on the increase in H3K56ac. Thus, it seems more likely that the modification occurs at the time of enhancer activation, although it may nevertheless involve nucleosome exchange. For example, SWI/SNF nucleosome remodellers have been found to act in combination with H3K56ac to promote nucleosome turnover and gene activity in yeasts. At several loci where changes were detected in H3K56ac, the modification extended broadly from the site of Su(H)/NICD binding, correlating with domains that already possessed H3K4me1. Along with data from other studies of enhancer activation, and the observation that levels of H3K56ac are affected by mutation of H3K4, this suggests that H3K4me1 is likely to be one of the earliest modifications, prefiguring sites of active enhancer. It may also facilitate the spread of H3K56ac across the regulated regions (Skalska, 2015).
Analysis of the relationship between chromatin states and regions occupied by Su(H) suggests that the pre-existing chromatin environment is likely to make an important contribution to recruitment. First, Su(H)-occupied motifs were almost exclusively located in highly accessible chromatin, with modifications such as H3K4me1 characteristic of enhancer states. Second, expression of the cooperating transcription factor Lz converted enhancers towards this preferred chromatin state where additional Su(H) was recruited. By having a preference for a particular chromatin signature, the vast majority (>91%) of potential Su(H) binding motifs will be masked by unfavourable chromatin. Indeed, the small fraction of sites that do not fit with this pattern may reflect false positives in the ChIP data or in chromatin assignment. The greater paradox is that only 7%-10% of CSL motifs within the favourable Enh chromatin were bound. Furthermore, many of the positions that were differentially bound in two cell types existed in Enh chromatin in both cell types examined. These observations suggest that additional factors restrict CSL binding to a subset of sites located within favourable chromatin. Such factors might include currently unknown histone modifications, protein-protein interactions, 3D organisation and/or DNA sequence properties around the CSL motif (Skalska, 2015).
Once bound, Su(H) itself also helps to shape the local chromatin environment. Depleting cells of Su(H) resulted in an increase in local histone acetylation (H3K27ac, H3K56ac), suggesting that, in the absence of NICD, Su(H) helps to suppress enhancer activity through its association with co-repressors. Thus, a model emerges in which Su(H) is recruited to regions that have already acquired regulatory competence and that it keeps these in a transitional state with low levels of H3K56ac. As there is considerable variability between enhancers, this suggests that each attains an activity that reflects the balance between the transcription factors promoting enhancer activity and those, such as Su(H), that can antagonise it. In those instances where Su(H)-corepressor complexes win out, then the enhancer is suppressed until the complimentary activity of NICD converts it from a transitional to an active state, a conversion that is associated with a large-scale increase in H3K56ac (Skalska, 2015).
The extent that the principles observed in this study will be of general relevance for other signalling pathways remains to be established, although it seems likely that their target gene specificity will be similarly dependant on the pre-existing chromatin substrate. However, it is possible that the inferred transitional enhancer states may be particularly relevant for those pathways/contexts where there is a fine-scale switch between repression and activation, as occurs for Notch and ecdysone signalling. Nevertheless, the correlation of H3K56ac with H3K4me1 suggests that H3K56ac is likely to be of widespread importance in enhancer activation. Whether this will be mediated through its direct effects on DNA-histone core interactions or through intermediate bromodomain containing proteins that link to the core transcription machinery, such as Brd4, remains to be determined (Skalska, 2015).
The deduced amino-acid sequence of Drosophila CBP predicts a protein of 332K relative molecular mass, which includes all the motifs found in the mammalian CBP/p300 homologs (Akimaru, 1997a).
date revised: 20 January 99
Home page: The Interactive Fly © 1995, 1996 Thomas B. Brody, Ph.D.
The Interactive Fly resides on the
Society for Developmental Biology's Web server.


text:
Nottinghamshire may face two of their former players when they head to Old Trafford to face Lancashire this week.
Both Kyle Hogg and Ashwell Prince spent the briefest of spells at Trent Bridge, Hogg in 2007 and the South African a year later. The visitors will also have a tie to the opposition, with Steven Mullaney having left Manchester for Nottingham a couple of years ago.
Those players are the latest in a line to represent both counties, following on from the likes of Jack Bond, Mark Crawley, Jason Gallian, Nathan Astle and Steve Elworthy.
Elworthy, the current ECB Director of Marketing and Communications, ended his first class career with a two-month spell at Notts in 2003.
"The opportunity to sign came out of the blue really," he reflects. "I'd just had the disappointment of missing out on the World Cup, despite being in South Africa's original squad of 18 but then losing out when it was reduced to 15.
"I got the call to come to Notts as the overseas player with Chris Cairns away with New Zealand and Stuart MacGill on duty with Australia."
The all-rounder played in five first class fixtures, making a top score of 52 and taking a total of 20 wickets.
"I really enjoyed my time at Notts, playing with guys like Paul Franks and Chris Read, who are still there. Kevin Pietersen and Usman Afzaal were still at the club, Bilal Shafayat and Charlie Shreck were doing well and there were a host of really talented youngsters coming through."
Elworthy admits he'd already grown fond of Trent Bridge, having made his Test debut on the ground, as well as making an appearance there in the 1999 World Cup.
"I loved playing there but that Test match in 1998 is something I'll never forget. It featured that epic duel between Allan Donald and Michael Atherton.
"To stand at mid-on and watch that was incredible. Donald just cranked up an extra yard of pace in a passage of play that has now become the stuff of legend. We thought Atherton had gloved one but it wasn't given and then he did nick one but Boucher put it down."
Elworthy had earlier spent one full season of county championship cricket, playing for Lancashire in 1996.
"I was really excited to be playing county cricket but I was being brought in as the overseas player to replace Wasim Akram. Those were really big boots to fill because he was a phenomenal player and whilst I wasn't a Wasim, I had a pretty good season and helped the side get through to two cup finals."
Now working for the ECB, the Zimbabwe-born 47-year old, was previously involved as the tournament director of both the 2007 and 2009 T20 World Cup competitions.
"That role enabled me to meet some really good people at Nottingham, people like Lisa Pursehouse and Derek Brewer. I remember spending an hour at Cape Town airport chatting to Derek and remember him being so passionate when talking about everything Trent Bridge had to offer."


text:
Turkey Stew
Recipe by NorthwestGal
Excellent use of leftover Thanksgiving turkey meat. Like many people, I have spent countless hours searching for unique and appealing ways to serve left-over turkey for the several days that followed our huge Thanskgiving feast. After trying several different soups and stews, my husband and I combined all the things we liked best about our favorite recipes and came up with this wonderful turkey stew recipe. It's our favorite, and the only turkey stew that we even eat anymore.
Top Review by Chef1MOM-Connie
For a cold blustery day this was the perfect meal to make. I have it simmering stovetop right now and cannot wait for dinner. Used leftover turkey from Superbowl Sunday to make this stewe. It is below 0 with the windchill factor. I used to noodles as oppesed to the rice (DH not a fan). I did make my noodles seperate so I can add it in just before dinner to warm through. I used a combination of acini de pepe and ditalini noodles. Ialso used homemade broth left over from the turkey cooking to reduce as much salt as possible and added in an extra clove of garlic and NO salt seasoning. This is a keeper. Made for Soup-Fest 2011
See Discussion:6 Reviews
Ingredients Nutrition
- 1 chicken bouillon cube
- 1 cup hot water
- 2 cups cooked turkey
- 1 large turkey bone
- 2 large carrots, cut into 1/2 inch pieces
- 4 stalks celery, cut into 1/2 inch pieces
- 1 small onion, chopped
- 1 tomatoes, chopped
- 3 tablespoons flour
- 1⁄2 cup uncooked white rice
- 1⁄2 cup uncooked wild rice
- 2 teaspoons parsley
- 2 teaspoons oregano
- 4 cups water
- 1⁄2 teaspoon salt (more or less, to taste)
- 1⁄2 teaspoon pepper (more or less, to taste)
Directions See How It's Made
- Dissolve the bouillon in the hot water to make a broth; set aside.
- Place the turkey meat, turkey bone, all the vegetables, flour, both rices, spices and chicken broth in a large kettle or Dutch oven
- Add as much of the 4 cups water as you prefer for desired consistency. Season with salt and pepper.
- Simmer over low heat for 30 to 45 minutes, or until the carrots and celery are tender and the turkey meat is heated through.
- Remove the turkey bone before serving stew.
- NOTE - you can easily use pasta in place of the rice. Just omit both the white and wild rices, and add about 1 cup uncooked egg noodles (or other pasta).
- TIP - I like to use a combination of white and dark meat when making this turkey stew, as I think it produces a much tastier stew. But you could easily use only white or only dark meat, to suit your taste buds.
- TIP - if you're watching your sodium intake, you can easily omit the chicken buillon cube in hot water and replace it with 1 cup of low-sodium canned chicken broth. For our health, we should consider this option but we are die-hard fans of this recipe and haven't been able to bring ourselves to do that -- at least not yet!


text:
Erica Lei Leerhsen is an American actress, best known for her lead roles in the box-office hit The Texas Chainsaw Massacre, and the sequels Wrong Turn 2: Dead End and Book of Shadows: Blair Witch 2. She is also known for her acting on television, such as her lead role in The Guardian and several guest appearances, including The Sopranos, Alias, and others. She was also voted #96 in 2001's Maxim Hot 100 and is referred to as one of todays "Scream Queens" as she has starred in numerous horror movies.
Early life
Leerhsen was born in New York City, New York on Valentine's Day, and raised in Ossining, Westchester County, New York, along with her two sisters, Nora and Debbie, by their father Charles Leerhsen, a long time editor of celebrity publication Us Magazine (which became Us Weekly in March 2000). She attended St. Augustine's School and Ossining High School (where she sang in the choir) and graduated from Boston University College of Fine Arts in 1998. She earned BFA (summa cum laude) in acting the same year.
After graduation, Leerhsen's first role was as Sarah in a 1999 short film Junior Creative, which received several good reviews. During its production, she got the lead role of a practicing witch in the controversial Horror sequel Book of Shadows: Blair Witch 2, though she originally auditioned for the part that eventually went to Kim Director. She went to the audition with short blonde hair, and, as director Joe Berlinger described it, "completely Gothed-out", but ultimately was given the role of Erica. It was Berlinger who decided to make her character a long-haired redhead.
Following Blair Witch 2, Leerhsen appeared in the third season of The Sopranos, where she played a lesbian tennis instructor who falls for Drea de Matteo's character. She then joined the cast of the well-acclaimed TV show The Guardian, however she left the show in the middle of the season to continue with pursuing her career. In the same year she had a supporting role in Woody Allen's Hollywood Ending.
Leerhsen was honored with the title "Arrow in the Head's Mistress of the Year 2003". That year saw the release of the successful horror remake The Texas Chainsaw Massacre, in which Leerhsen had a lead role as one of the doomed teens. During her screen test for the film, her screams were so loud that people on other floors of the building called the police to report that a young woman was being attacked. The same year she returned to acting on television with a guest appearance on Alias, and then reunited with Woody Allen in his new film, Anything Else.
In 2004, Leerhsen starred in an independent Thriller The Warrior Class, where she played Anson Mount's love interest. The film got released on DVD on February 6, 2007. Months later, she started acting in theaters, and appeared in Woody Allen's A Second Hand Memory, which attracted attention from a wider adult audience and received good reviews.
A year later, Leerhsen starred along Michael Pena in an independently-made Toronto Film Festival-smash Little Athens, which got released on DVD on November 21, 2005. The same year she had a guest appearance on Jennifer Love Hewitt's television show Ghost Whisperer, and starred in Mozart and the Whale, which was released in limited theaters on April 14, 2006.
The year 2006 opened with Leerhsen's guest appearance on CSI: Miami. Shortly after, she was landed a starring role in Wrong Turn 2: Dead End, the successful 2007 sequel to the 2003 horror film Wrong Turn, where she did a lot of her own stunts. The sequel got released on DVD on October 9, 2007 in USA, and January 8, 2008 in UK.
Before filming Wrong Turn 2: Dead End, Leerhsen shot a Horror/Thriller Living Hell, where she played a hazmat specialist. The film premiered on the SCI FI Channel on February 23, 2008, and got released on DVD on June 10 in USA.
In 2007, Leerhsen starred in an indie film Lonely Joe, which has been said to be a Supernatural Horror/Thriller "in the veins of Saw and The Sixth Sense", and has been slated for an unknown 2009 release. Her most recent projects have been a Thriller The Message, and 3 upcoming films: an Aussie Horror/Thriller The Fury, Shiver, a Thriller directed by Lucky McKee, and a horror film Slaughter.
Personal life
Leerhsen enjoys running, playing basketball and Yoga. She currently lives in Los Angeles and is good friends with actress Emily Deschanel, with whom she went to the same college.
Commenting on the characters she often plays, Leerhsen has said: "It's weird because I always seem to be dead. I'm gonna have to change that because I wouldn't want to be typecast."
Buy Movie Tickets


text:
|This company is or has gone private. Information about the company may be limited and outdated.
Tektronix (TEK) is a leading supplier of test, measurement, and monitoring products, solutions and services for the communications, computer, and semiconductor industries — as well as military/aerospace, consumer electronics, education, and a broad range of other industries worldwide.
With over 60 years of experience, it provides general purpose test and measurement; video test, measurement, and monitoring; and communications network management. The company derives revenue principally by developing, manufacturing, and selling a broad range of products and related components, support services, and accessories.
The company is organized around two business platforms: the Instruments Business and the Communications Business. The Instruments Business includes general purpose test and measurement products; video test, measurement, and monitoring products; and Maxtek Components Corporation, which manufactures sophisticated hybrid circuits for internal use and for external sale. The Communications Business includes telecommunications network management solutions and services and network diagnostics products.
Based on preliminary independent research for calendar year 2006, the overall test and measurement market is an approximately $10 billion market and includes general-purpose test; communications test and monitoring; video test, measurement and monitoring; and card modular instrumentation. The general-purpose test segment is the broadest of these segments and represents a wide range of tools used by customers across many industries and applications. The communications test segment is focused on application-specific products and solutions for communication equipment manufacturers and network operators. Video test equipment is used by manufacturers, content developers, broadcasters, and distributors of video content to test and monitor the quality of traditional and digital video signals. The card modular segment is focused on a broad set of customers primarily performing automated test.
Instruments Business offers general purpose test products, including oscilloscopes, logic analyzers, signal sources and spectrum analyzers, and a variety of video test, measurement, and monitoring products.
Communications Business offers network diagnostic equipment, network management solutions, and related support services for both fixed and mobile networks. See Note 22 "Business Segments" of the Notes to the Consolidated Financial Statements in Item 8 Financial Statements and Supplementary Data, which contains information on sales by groups of similar products.
General purpose test products include oscilloscopes, logic analyzers, signal sources, and spectrum analyzers. Oscilloscopes are the primary general purpose electronic debug tools. Logic analyzers are debug tools used by design engineers to capture, display, and analyze streams of digital data that occur simultaneously over many channels. Signal sources are general purpose stimulus products primarily used in the design and manufacturing of electronic components, subassemblies, and end products in a wide variety of industries. Spectrum analyzers are primarily used in the design and manufacturing of electronic components, subassemblies, and end products which utilize digital RF technology. Real-time spectrum analyzers enable customers to perform simultaneous frequency, time, and modulation domain measurements on radio frequency signals. They are used in a wide range of industries and applications including, but not limited to, cellular, wireless local area networks, surveillance, radar, and all other products using digital radio technology.
Product offerings include waveform monitors, video signal generators, and compressed digital video test products. These products are used in video equipment design and manufacturing, video content production, and video transmission and distribution.
Network management and diagnostic tools enable network equipment manufacturers and operators to develop, deploy, and manage mobile and fixed line networks. Network management tools provide continuous performance management to optimize the service performance of an entire communications network. Diagnostic tools test and monitor the signaling protocols in next-generation communication networks and services.
Due to the convergence of voice, data, and video into the latest generation IP multi-service mobile and fixed networks, the requirements for monitoring and testing networks and elements in operation have changed and have become more complex.
The company offers service programs to repair and calibrate its products with service personnel throughout the Americas, Europe, the Pacific, and Japan. These programs provide customers with short term support in response to a number of possible circumstances.
Maxtek Components Corporation, a wholly-owned subsidiary of Tektronix, manufactures sophisticated hybrid circuits for our internal use and for external sale, primarily to customers in the automated test equipment and medical equipment industries, and for military applications.
Primary manufacturing activities occur at facilities located in Beaverton, Oregon and Shanghai, China. In addition, it performs light assembly and software configuration activities in Richardson, Texas, and software configuration services in Berlin, Germany. It perform installation and integration activities for its network management products at customer sites using internal direct labor and third-party integration providers. These installation and integration activities occur in the Americas, Europe, the Pacific, and Japan.
Principal customers are electronic and computer equipment manufacturers and service providers, communication network equipment manufacturers, network operators, semiconductor manufacturers, private industrial concerns engaged in commercial or governmental projects, military and nonmilitary agencies of the United States and of foreign countries, educational institutions, and radio and television stations and networks. Certain products are sold to both equipment users and original equipment manufacturers.
Most of the products are sold as standard catalog items. Network management products require customization, system installation, and customer acceptance.


text:
In Adobe Professional Services, we are big on software craftsmanship. We are committed to clean code, T.D.D., the SOLID design principles, and the idea that craftsmanship will increase customer value. This is not always an easy crusade to be part of, largely due to the fact that our work is usually beholden to the needs of our customer. There are many cases where the customer may make demands that suggest we compromise our standards. For some, this is a cry to battle, and the ensuing tension can make a project troubled, to say the least. There are times when this seems to come down to an 'all or nothing' stand on quality, with 'push back' being the war cry of developers. I feel this is a common pattern in the software industry, but extreme stances are never a good way to get things done. This is where Agile comes in.
Agile is the rule of the land in Professional Services (and across many product teams at Adobe). There is an important aspect of Agile that may help move things away from an all or nothing dialog around the inclusion of quality in delivery. In general, Agile can be seen as guidelines for achieving balance. In Agile's very definition, the things that are 'favored' (individuals, interactions, working software, collaboration, response to change) are just that; favored. They aren't strictly demanded, and there isn't a formula for measuring the percentage of implementation. Problems come when any one principle is 'favored' more than another. In this case, the 'commit to technical excellence and good design' principle of Agile can be taken to an extreme, while the customer may be taking 'deliver working software of business value' to their own extreme. If either principle becomes a goal in itself, this begins to limit the inclusion of other, equally important goals.
The frustrating thing for developers, especially those committed to quality, is that business value should ultimately be decided by the customer! In the end, we should strive to provide quality as a rule, but the customer keeps the lights on, so delivery should take precedence. If the customer is not giving enough allowance for quality, one approach is to help them see the business value of quality, rather than simply pushing back. However, Agile provides other ways for developers to shield themselves from focus moving too far toward delivery.
Another principle is the idea of "maximizing simplicity", which is measured by the amount of work *not* done. Delivery of working software is supposed to be the *only* measure of progress. However, a good team can work within that definition to provide an adequate balance between value, architecture, and quality. Craftsmanship, pragmatically applied, is non-negotiable. The point of balance is to be doing just enough, while not becoming and end in itself. This is the same principle behind stories being a seed, rather than detailed requirements, and the deferred design that comes in sprint planning. The 'just enough' idea should be able to provide some padding for the dev team, so that quality doesn't have to be completely dropped in the face of delivery pressure.
In the end, the tension between customer and developers is probably a good thing. A team with out constraints may tend toward over-architecting, and a customer with no technical resistance is likely to create low quality software. For me, a big selling point of Agile is how the principles work together to make life better for both development and the customer.


text:
TMG-L ArchivesArchiver > TMG > 2003-09 > 1062967052
From: Eric Haas <>
Subject: Re: [TMG] names and roles
Date: Sun, 7 Sep 2003 16:37:38 -0400
References: <000101c3757d$64437490$6401a8c0@LAPTOP>
In-Reply-To: <000101c3757d$64437490$6401a8c0@LAPTOP>
Sunday, September 7, 2003, 4:19:50 PM, Cheryl Chasin wrote:
CC> I'm doing my first real experimenting with using roles in TMG (v5.09). I
CC> have (with the assistance of Theresa's website) roles and sentences I'm
CC> pretty happy with except for one little thing. I would really like my
CC> sentences to list married women as they appeared in the census, i.e. using
CC> their married names not their maiden names. Is there any way to do this
CC> using name variables? I don't want it badly enough to write a separate
CC> sentence for each census tag as I enter it.
If you have Name-Marr tags for them, yes. When you enter a tag, look
on the top right side of the tag entry screen. There will be two boxes
that say "Primary Name", one for each principal. If you click on the
arrow button attached to the box, you will see a list of all of the
available names for that principal. Select one of the names and, TMG
will use that name for that tag.
You have the same options when you add witnesses to a tag.
This thread:
|Re: [TMG] names and roles by Eric Haas <>


text:
hi friends
i need your help! i am getting this error ! in webmaster tools in my site smashinghub.com
Google couldn't crawl your site because we were unable to access the robots.txt file.robots.txt.
i attached the image as reference ... and foundNot found126 ....
kindly check and help me to fix the problem
Hi,Try access the robots.txt file in your browser. If it is displayed, maybe it was a problem with the hosting server when google tried to access the robots.txt file.But if the server is working now , the problem should be also fixed in web master tools in one or two days.


text:
Ultimate Portable folding grill table / tailgating by baseballtime
I just bought one of these, use it for camping and baseball games, my kids use it for pizza night. I can not believe how light it is and it folds up and fits into the trunk of my car. This is a wonderful table.


text:
Produced for:
When Greater St. Stephen Full Gospel Baptist Church lost their Central City location to an electrical fire, they found a temporary home inside Temple Sinai. As the Jewish synagogue rings with gospel praise, the circumstances give rise to a new friendship between the two congregations.
Update Required To play the media you will need to either update your browser to a recent version or update your Flash plugin.


text:
Clube Pinhal da Foz Apartment
Rua Joao Ferreira da Silva, Esposende, Portugal
- Free Wi-Fi
- Self-Catering Facilities
- Airport Transfers
- Bar
- Bicycle Hire
- Bicycle Parking
- Book Exchange
- Breakfast Not Included
- Cable TV
- Café
- Children's Play Area"
- Cots available
- Fitness Centre"
- Free City Maps
- Free Internet Access
- Free Parking
- Fridge Freezer"
- Games Room
- Hair Dryers
- Hot Showers
- Internet Access
- Iron / Ironing Board"
- Linen Included
- Luggage Storage
- Microwave
- Outdoor Swimming Pool
- Outdoor Terrace
- Parking
- Safe Deposit Box
- Tea/Coffee Making Facilities
- Telephone Fax Facilities
- Towels Included
- Utensils
- Wheelchair Friendly
Check-in / Check-out
Earliest check-in: 15:00
Latest Check-out: 10:00
- Child Friendly
- Credit Cards Accepted
- Non Smoking
- Taxes Included
Group booking?
Group of 15 or more traveling to Esposende?
Private Rooms
Standard 2 Bed Apartment Ensuite
Sleeps 2
Room types
Private Room
Private Bathroom
Standard 1 Bed Apartment Ensuite
Sleeps 1
Room types
Private Room
Private Bathroom
About Clube Pinhal da Foz
Here visitors can take advantage of all Nature - sea, river, beaches and mountain - as well as - warmed swimming-pools, golf, tennis-court, disco, horsemanship and nautical sports.
Markets, exhibitions, workmanship and gastronomy complete the fascination of this touristic station. The Clube Pinhal da Foz is, certainly, a good harbour of refuge to all people who are attracted for the beautiful and the green Minho, and people who go to the conquest of the unforgettable holidays.
Accommodation Information
The Clube has 16 Touristic Apartments type T1 duplex available, all of them furnished and with the capacity of 4 people, they can be rented for periods of 1 or more days.
It also has, a tennis-court, a swimming-pool for adults and children, a gymnasium room and a sauna, two bars with esplanade, living room and garages.
Location Information
It is situated in Aldeamento Pinhal da Foz, near the marginal road and the mouth of the river Cávado, next to the beach and surrounded by excellent restaurants, snack-bars and super-markets.
It is the only one of its kind and, in the area where is located, Esposende/Alto Minho, it is wonderful for the enjoyment of holidays and quiet weekends with an excellent weather from May till October.
Cancellation Policy
Customers can cancel their reservation free of charge up to 3 days before arrival. After this date, charges will be applied by the property up to the first nights cost of the reservation, unless otherwise stated in the property's conditions. Deposits paid are non refundable.


text:
Gays & GOP
The seemingly impossible has happened. A Republican representative of a rural district in central Pennsylvania, who describes himself as a conservative and a Christian, has become the first openly gay member of the state Legislature ("Central Pa. GOP lawmaker tells newspaper he's gay," Dec. 2 and TribLIVE.com).
Rep. Mike Fleck's decision to come out will likely have lasting implications for the party he represents. I hope his announcement will also highlight the presence of a largely ignored demographic: gay men and women who lean right.
Despite his opposition to gay marriage, exit polls reveal that Mitt Romney was supported by almost a quarter of voters who identified themselves as gay, lesbian or bisexual. Believe it or not, there are people within the LGBT community who appreciate the importance of fiscal responsibility, tough national security strategies and the creation of innovative jobs, not just those considered "green."
Until the next election cycle, the GOP has the opportunity to broaden its base by improving its standing among all gay Americans. With Fleck as an example, party leaders who are more accepting of gays will inevitably emerge. Until that time, Republicans would be smart to embrace this important faction that can help them win elections.
Ryan Navarro


text:
In the middle of H&R and Bilstein Sport Install, have a few quick questions.
View Single Post
Registered User
Join Date: Jul 2006
Location: Cincinnati
Posts: 70
My Ride: '03 330i 6MT, '01 M5
View My Garage
I put the same combo on my 330i last Sept and here are my thoughts from what I learned.
1) You do not use the bump stop on the front struts with the Bilsteins. They do not need them and there is no room.
2) That is what I did but I do not think it makes too much difference as long as the are close.
3) The strut will not go all the way through. There is a lip at the bottom of the mount.
4) I just used an air wrench to tighten things down. That was the suggestion to me from a mechanic.
I think that is everything... if not let me know if you have more questions.
View Public Profile
Find more threads by nightowl2k2
Find More Posts by nightowl2k2
Leave feedback for nightowl2k2 (0)


text:
Subject: Re: [htdig] Ignore robots.txt and META-Tags.
From: Gilles Detillieux (email@example.com)
Date: Tue Jan 25 2000 - 15:59:20 PST
According to Sven Hartge:
> We want to index our local server using htdig. There is only one slight
> problem: We have several META-tags in our files, to prevent external
> search-enginges to crawl through the whole server. Now, htdig honors
> these tags too and indexes only some pages. I used an old release and
> manually patched the check for no-index out of the source, but this is
> way to much work to do, if I need to upgrade the htdig version (and is
> definately not a right thing [tm]). I've read the documentation which
> comes with htdig and also searched through the website, but ... I am
> _sure_ I am missing something here.
No, the only way to get htdig to ignore META noindex tags is to patch
the source. If you want to allow some search engines but disallow
others, the place to do this is in robots.txt, which allows different
rules for different user agents. META tags are meant to apply to any
web client smart enough to use them.
> Oh, and a next one: Is it possible to search for words containing umlauts
> (äöüß) if there are _no_ locales installed? I do not have root-access so
> I won't be able to install them in the right places. Will htdig work, if
> they are installed somewhere in the /home-directory of the user?
No, unfortunately, that's one of the big problems with locales -
if they're not set up correctly on your system, you're out of luck,
unless you can coax your sysadmin to install them for you, and provided
the system's C library support for locales isn't broken. I've proposed
a mechanism for overriding bad/broken/missing locales, but no one has
implemented it yet.
-- Gilles R. Detillieux E-mail: <firstname.lastname@example.com> Spinal Cord Research Centre WWW: http://www.scrc.umanitoba.ca/~grdetil Dept. Physiology, U. of Manitoba Phone: (204)789-3766 Winnipeg, MB R3E 3J7 (Canada) Fax: (204)789-3930
------------------------------------ To unsubscribe from the htdig mailing list, send a message to email@example.com You will receive a message to confirm this.
This archive was generated by hypermail 2b28 : Tue Jan 25 2000 - 16:00:47 PST


text:
By Michael Marot, AP Sports Writer
BLOOMINGTON, Ind. Passion led Tom Crean to Indiana. Success could turn him into a statewide folk hero.
The former Marquette coach jumped right into the high-stakes game of Hoosiers basketball on Wednesday, accepting the challenge of rebuilding the school's tattered reputation and restoring its national appeal despite all the blemishes surrounding the program.
"This place, this university, this program, for as long as I can remember, has stood for class and integrity, doing the right thing and being the right way," Crean said during his introductory news conference. "We're not going to be overwhelmed by the challenges, we're going to embrace them."
To show he was all in, Crean went all out.
Before stepping behind the podium, he met with his new players, told stories and offered to have more meetings before he heads to San Antonio for the Final Four. The 42-year-old coach, who grew up in Michigan, even took a moment to shake the hand of football coach Bill Lynch.
"I haven't gotten a chance to work with a football coach in a long time," joked Crean, who spent the past nine seasons at a non-football playing school.
Crean also walked over to his family, kissed his wife, Joani, and two of his three children - the 2-year-old ran off to find stickers. Finally, he held up a newly printed T-shirt that read "Crean and Crimson," a play on the school colors, cream and crimson.
Despite Crean's charming wit and enthusiastic personality, the honeymoon will be short.
He must deal with the taint of last season when Indiana's once-impeccable image for playing by the rules was shattered by allegations of Kelvin Sampson making impermissible phone calls. The NCAA accused Sampson of committing five major infractions, which led to Sampson's resignation Feb. 22.
The university's self-imposed punishment includes the loss of one scholarship next season.
And, of course, he must win.
So Indiana is giving Crean some extra time to clean up this mess.
He agreed to an eight-year deal worth $18.24 million, an annual average of $2.3 million - believed to be the largest in school history. It's more than double what Sampson was scheduled to make last year, $1.1 million, and is a year longer than the contract Sampson signed in 2006. Sampson also accepted a $750,000 buyout to resign on Feb. 22.
While Crean pleaded for the patience of fans to right things, the coach who took Marquette to the 2003 Final Four acknowledged he will rely on his trademark recruiting skills to sign players who can meet the expectations of a school looking to cleanse its stained image.
"I'm going to look for people who understand why we wear the candy-striped pants and why we wear Indiana on our jerseys," he said. "Our eyes are wide open right now for Indiana basketball, and we can't wait to get started."
The Hoosiers can't wait to start over, either, after one of the bleakest seasons in school history.
Player suspensions, player dissension, the NCAA allegations and a midseason coaching change overshadowed everything Indiana did on the court - won 25 games; was in contention for the Big Ten title; spent all but one week in the Top 25.
Then came the two-week coaching search.
The combination made players anxious, and they're hoping Wednesday's announcement will finally provide a respite from their turbulent six-month whirlwind.
"I think it helped to find a coach and get everything behind us," forward Eli Holman said. "It's like another chapter to a book."
Despite his enthusiasm, the new coach can't solve every problem.
Indiana is scheduled to have its hearing in front of the NCAA infractions committee in June, and there is no indication whether the school could face an even harsher punishment when the ruling is handed down.
Two players, starting guards Armon Bassett and Jamarcus Ellis, were kicked off the team by interim coach Dan Dakich on Tuesday, before Crean was hired. Athletic director Rick Greenspan said he would let Crean make the decision about possible reinstatement. Players said they were told Crean would meet with both players later.
Still, Crean, a longtime admirer of Indiana basketball, found the job attractive.
He said he made his decision between two phone calls from former college coach Eddie Fogler, who was a consultant to the school's 10-member search committee.
"This was a heart decision," Crean said, his voice cracking. "This was not a business decision or a legacy decision. I'd had other opportunities to walk away, and none of them felt like this. I'm going to miss those people a lot, but I'm excited to be here."
Somehow, though, the hiring of the most prominent employee at Indiana University - men's basketball coach - still got upstaged even in this basketball-crazy state.
Instead of holding the news conference on the Assembly Hall floor, as was the case for Mike Davis and Sampson, it was moved to a room underneath the football stadium because a Hillary Clinton rally was scheduled Wednesday afternoon in Assembly Hall.
The players were just happy it was over.
"It didn't seem quick enough, it's been horrible for us," Jordan Crawford said of the search. "It was a very long season, a lot of stuff happened, so it's good to start it over and have a better season."
The hiring of Crean, Indiana hopes, will make that possible.
"He's very excited about the job," Crawford said. "Indiana is a good job. If you're doing good, everyone talks about Indiana University as a big-time school, and he's very passionate about it. So he's going to work hard to get the job done."
The Associated Press


text:
McAree Engineering Corporate Video
McAree Engineering is one of Irelands leading outsource sheet metal fabrication companies based near the picturesque village of Ballinode in North Monaghan.
Founded in 1946 we have built a solid reputation for quality service backed up by state of the art production facilities. We believe that the long term future of our company is to be our customers preferred and trusted partner, providing best in class, quality and service. We do this by having a proactive customer focus by supplying solutions to meet your current & future needs with a constant emphasis on Innovation, Quality and Value.
We have invested heavily in top of the range equipment to ensure reliability and consistency in all our fabrications.
Our Quality system is approved to ISO 9001 standard.


text:
She's been a busy lady as of late, and this morning (July 16) Kristen Wiig showed up at ABC Studios in New York City for a promotional appearance.
The "Bridesmaids" babe was in the house to plug a pair of new flicks on "Good Morning America" including the already-released "Despicable Me 2" and the forthcoming "Girl Most Likely."
Gearing up to promote her new comedy, Kristen Wiig attended a screening of Lionsgate and Roadside Attractions "Girl Most Likely" in New York City on Monday (July 15).
The "Saturday Night Live" alum wore a white satin short-sleeved dress with pale pink heels as she posed for photos with her co-stars outside.
Giving movie buffs a sneak peek of what's to come, Dreamworks Animation debuted a teaser trailer for "How to Train Your Dragon 2" on Saturday (July 13).
The sequel to the 2010 animated hit has an all-star cast, including Kristen Wiig, Jonah Hill, and Gerard Butler to voice the film's characters.
It was literally one of the funniest movies of the decade, and "Bridesmaids" almost begged for a sequel, given its success.
However, Kristen Wiig told Harper's Bazaaar that there's no way she'll sign on for a second installment, regardless of the paycheck.
It's almost time for the minions to hit the big screen, and on Wednesday (June 26) Universal Pictures released two new television spots for "Despicable Me 2."
Voiced by Steve Carell, Kristen Wiig, and Miranda Cosgrove, among others, the second installment of the animated comedy follows Gru being recruited by the Anti-Villain League to help deal with a powerful new super criminal.
Hoping for a big summer blockbuster, the cast of "Despicable Me 2" headed to the premiere in Universal City, California on Saturday (June 22).
Stepping out to support the family flick were Steve Carell, Kristen Wiig, Benjamin Bratt, Miranda Cosgrove, Steve Coogan, Ken Jeong, and the film's composer, Pharrell Williams.
Checking out the City of Lights, Kristen Wiig took a solo stroll through the streets of Paris on Thursday (June 19).
The "Saturday Night Live" alum looked cute in a yellow long-sleeved top, black pants, and black and white heels as she smiled for photographers.
Showing some love to their French fans, Kristen Wiig and Darren Criss showed up at the premiere of their new film "Girl Most Likely" in Paris last night (June 18).
The "Bridesmaids" babe and her "Glee" guy both looked snazzy as they hammed it up as part of the 2013 Champs Elysees Film Festival at Publicis Champs Elysees while shutterbugs looked on.


text:
Tiered Pom Pom Scarf by Forever 21
Trimmed with fun pom poms, this vivid beauty is bound to cheer up your outfit (and maybe even your day). Also available in cream, coral, and blue.
To buy: $8, forever21.com.
Get Daily Finds via e-mail
See all Daily Finds from this month


text:
2 Vintage Plasticville Cape Cod Houses Kits #'s 79 & 9 , w/ Original Boxes
- Sold for: Start Free Trial or Sign In to see what it's worth.
- Item Category: Toys, Dolls, Games & Puzzles
- Source: eBay
- Sold Date: Mar 01, 2013
- Channel: Auction House Sell similar item on eBay
This auction is for 2 Vintage Plasticville/ Bachmann buildings, Cape-Cod Houses # 9 and 79, O Scale, All the pieces have been accounted for, they might need a little cleaning. Boxes are in fair shape. This would be a great addition to your collection.. Please look closely at the pictures before bidding.Please ask any questions before you bid and I will answer to the best of my ability. Thank you for looking. I strive for 100% customer satisfaction, if there is ever a problem please contact me first so we may work it out.


text:
The prices of potassium (K) fertilizer and other fertilizers have increased significantly during the last two years. Profitable crop production requires appropriate soil K levels so careful fertilization planning is required.
Iowa State University soil-test interpretations and fertilizer recommendations were updated in November 2002. Two important changes were to recommend higher soil-test K (STK) levels for optimum yield of Iowa crops and to suggest efficient K fertilizer application methods for some conservation tillage systems. These recommendations are explained in Iowa State University Extension publication PM 1688, A General Guide for Crop Nutrient and Limestone Recommendations in Iowa [1], which is available onlne or at your county extension office.
A need to update the soil-test interpretations for K was first identified during the mid- to late 1990s because of increasing frequency of K deficiency symptoms in corn and sometimes soybeans in some soils that tested in the older High soil-test category. Recent field response experiments have confirmed that the interpretations in use until 2002 often recommended too little or no K fertilizer for fields with a high probability of yield response and that the current higher STK recommendations are appropriate for most Iowa fields. Dense soil sampling and spotty deficiencies in many fields during the last few years have indicated that the most common reason for deficiency symptoms is low STK levels. However, K deficiency is sometimes observed on soils with apparently adequate K levels because it is induced by other factors. See issue 15 (6/20/2005) of the ICM Newsletter, Potassium deficiency symptoms in corn and soybean: What can we do about them? [2]; for a more detailed discussion of reasons for K deficiency, go to www.ipm.iastate.edu/ipm/icm/.
As an example of recommendations found in publication PM 1688, Table 1 shows the current STK interpretation classes defined for soil series with fine texture and low subsoil K. For these soils (the majority in Iowa) the recommendation is to maintain STK within a range of 131 to 170 ppm K for both corn and soybean. The maintenance fertilization for this class should be based on estimates of nutrient removal with harvest for each field. Information for average K concentration in harvested plant parts is provided in PM 1688. Research has shown that fertilization before one crop to supply the needs of a 2-year sequence of the corn--soybean rotation has similar efficiency as fertilization before each crop. Suggested K rates for this fertilization strategy are included in Table 1.
The results of numerous Iowa field experiments that evaluated fertilizer placement methods since the mid-1990s indicated a benefit of deep K placement for corn and soybean managed with no-till and ridge-till systems.
With these tillage systems, broadcast fertilizers are not incorporated or are incorporated in a way that may not optimize early nutrient uptake (such as in ridge-till). Continued broadcast or planter-band fertilization and nutrient recycling with crop residues results in large K accumulation near the soil surface. The benefit of deep-band K applications (5 to 7 inches deep) was larger and more consistent for ridge-till than for no-till and was not significant on fields managed with chisel-plow tillage. Large variation in the no-till response to deep-band K appears more related to soil moisture than to STK stratification, and responses tend to be larger when rainfall is deficient in late spring or summer. Annual deep applications are not essential, and soybean benefits from one deep application before corn as long as the needs of the two crops are supplied.
Based on these results, deep-band K fertilization is suggested as an improved placement method for no-till and ridge-till management. The recommended fertilization rates are the same for both broadcast and deep banding, as research indicates no differential rate response between placement methods. It is important to note that the yield increase of no-till crops from deep K banding is not always large (even when done in combination with strip tillage for corn), and often may not offset increased application costs due to currently high fuel and fertilizer prices.
Producers and crop consultants need to understand that we always have to deal with probabilities concerning crop yield response to fertilizer application. Research indicates a very high probability of crop response to K in low-testing soils, on average a 25 percent probability of response in soils testing Optimum, and a much smaller probability (less than 5%) in high-testing soils. However, the probability of crop response to K in the Optimum category is higher for poorly drained and finer-textured soils in low landscape positions than for better-drained soils.
Producers can save money by withholding K fertilization in high-testing soils. Use of variable-rate K fertilization is a very good option in fields that have variable STK levels and have shown spotty K deficiency symptoms. This technology can be used to target applications to the most deficient field areas to get the highest possible return when the grain/fertilizer price ratio is unfavorable. Research also shows that when STK is in the Optimum category, the corn yield response achieved with a starter application (10 to 14 lb K2O) or a larger maintenance K application often are similar. Obviously, applying only starter K fertilization for corn will not supply enough K for the following soybean crop and maintain soil tests over time. The strength of the research results does not allow for specific recommendations concerning use of one or the other option but shows that a rate lower than the maintenance rate could be considered as a short-term measure in well-drained soils testing within this category when fertilizer prices are high in a particular season.
Because the probability of response in the Optimum category is lower than in low-testing soils, issues such as land tenure, the producer's financial condition, and the producer's attitude about risk play a significant role when making a decision for fertilizing soils when prices are unfavorable.
Table 1. Soil-test K interpretation categories (ammonium-acetate or Mehlich-3 tests) and K fertilizer recommendations for corn and soybean. These are for soil series with low subsoil K and fine texture, which predominate in Iowa.
|K Fertilizer Rate
|Soil-test K
|Soil-test K
|ppm lb K2O/acre
|Very low
|Very high
* The fertilizer amounts for the Optimum category assume corn and soybean yields of 150 and 55 bu/acre, respectively.
# A partial crop removal rate may be applied when the soil test is in the lower part of the High category. See publication PM 1688 for more detailed information.
This article originally appeared on pages 180-181 of the IC-494(23) -- September 19, 2005 issue.


text:
UK Car
UK Car Repair Questions? Ask a Mechanic for Answers ASAP
Welcome to Just Answer
Have any other items on the car stopped working, such as wipers, lights heater etc?
Do you have a spare key?
The program is with the immobiliser, which wont show up on the diagnostics as a fault unless you have a peugeot diagnostics system where you can scrutinise it.
The most common cause of immobiliser failures in these is the transponder reciever on the ignition barrel, it takes about 20 minutes to change, and costs about £18 for the part from the main agents, so it is worth a try first off, also check the wiring to this.
If this dosent work, the next thing to do is to try re-programming the immobiliser with a suitable diagnostic computer, if you garage dosent have one, then contact an auto locksmiths or auto electrical specialist ewho will have the equipment.
Hope this helps, if you need more info, please let me know.


text:
Authors protest at 'appalling' cull of Newcastle libraries
Authors Philip Pullman, childrens laureate Julia Donaldson, Malorie Blackman and Meg Rosoff are among those protesting about the news that the bulk of Newcastle's 18 libraries are to be closed or handed to community groups.
It has emerged in local reports that the majority of branch libraries facing closure, with the exact number to be confirmed this week but only the newly rebuilt city centre library safe from the axe.
Council leaders are expected to say that those libraries not already part of a customer service centre or shared with another council will go as it looks to save £7m from its library budget.
Library services director Tony Durcan said: "We are in this position because frankly we cannot go on as we were before. We face significant spending cuts and that will have a substantial impact on our budget."
Author and library campaigner Alan Gibbons has co-ordinated an open letter to Newcastle's councillors calling on them to think again. Pullman, Donaldson, Blackman and Rosoff have all signed the letter, along with former childrens laureate Anne Fine, Beverley Naidoo and many others.
"We are authors, many of whom have attended the Northern Children's Book Festival and other events in the region over many years," the letter states. "We have enjoyed the tremendous warmth and hospitality of young book lovers in the North East and the librarians and teachers who introduce them to the joy of reading.
"We are therefore appalled to hear that council leaders are planning draconian cuts to the city's libraries. The UK is 25th in the PISA international reading rankings. This is no time to cut libraries. It is the young and the elderly who disproportionately depend on branch libraries. The cost in educational underachievement would far outweigh any savings made by cuts.
"It is not the role of a Labour council to act as a conduit for the coalition government's 'austerity' cuts which disproportionately hit the poorest and most vulnerable. We call on Newcastle's councillors to reconsider this wrong and immoral course."
Editor's blog: Libraries on the brink


text:
August 21, 2016
by @notalemming
by Civilus Defendus, with a hat tip to Kali Politus (Video by LSA, PDF version here. Click, save, share.) STAGE 1: INFILTRATION Muslims begin moving to non-Muslim countries in increasing numbers and the beginning of cultural conflicts are visible, though often subtle. First migration wave to non-Muslim "host" country. Appeal for humanitarian tolerance from the…
February 25, 2016
by @notalemming
Originally posted on Pax Vobiscum:
Twitter is cracking down on the dissident right. They banned-for-life my co-founder Charles Johnson in May 2015, and in the latter part of the year were caught preventing anti-feminist as well as pro-Trump hashtags from autocompleting. Now Twitter has formed the "Trust And Safety Council", a name which is so feminist…
Don LeBaron on Liberty and the Ancient Law
If you have a problem with AMERICA maybe it's time to leave
The World's Only Reliable News
illuminating minds
welcome to my little part of things
οἱ θεοὶ πολλοί, οἱ ἄνδρες ὀλίγοι
RADAR, Satellite, Solar, Earthquake, and Radiation Links
Defending Life, Liberty and the Pursuit of Happiness
Random Offensive Conservative Commentary
America needs saving
Talk Host on The Blaze Radio Network
DISPATCHES FROM THE CAMP OF THE SAINTS [DHS-Certified Rightwing Extremist / White House Certified 'Fishy' / Carter-Certified Raaaaacist! / Kafir]
News you need to know to stay informed
The Monica Perez Show is on every Saturday 3-6PM on News 95-5 & AM750 WSB & iheartradio.


text:
GMC Terrain 2014 Prices in UAE
GMC Terrain 2014 Specifications
GMC Terrain Reviews
GMC Terrain 2014 Features Overview
General Motors expanded their line-up of compact crossovers with the GMC Terrain in late 2010, a soft-roader featuring squared-off edges and flared fenders. There is a choice of two engines from 2013 onwards, namely a 2.4-litre 4-cylinder and a 3.6-litre V6, both featuring "SIDI" direct injection, a 6-speed automatic, and either front-wheel-drive or all-wheel-drive. The interior features ambient lighting, clever storage spaces, a closed compartment under the center armrest for a notebook binder, four power outlets, optional power liftgate, basic keyless entry with optional remote start, single-zone a/c, CD/MP3 stereo with USB support, optional 8-speaker premium audio with available 10GB hard drive with DVD and navigation, optional DVD rear-seat entertainment with two screens, optional power driver's seat, standard rear camera, optional sunroof, common power accessories, cloth or leather upholstery, and a choice of 17-inch, 18-inch and 19-inch alloy wheels. A Denali version was offered from 2013, with a chrome grille and some additional chrome trim. Safety features include stability control, traction control, six standard airbags and ABS disc brakes.
GMC Terrain Reliability & Resale Value
GMC Terrain Safety Ratings
Competitors to the GMC Terrain
GMC Classifieds


text:
Astronomy & Astrophysics
Faculty in the Astronomy Program carry out research in solar, stellar, galactic, and extragalactic astronomy. This research involves observations with groundbased and spaceborne telescopes – including the National Optical Astronomy Observatory (NOAO), the Very Large Array (VLA) of radio telescopes, the Solar Heliospheric Observatory (SOHO), the Hubble Space Telescope (HST), the Chandra X-Ray Observatory, and the Spitzer Space Telescope.
Condensed Matter
Experimental research in polymer and biopolymer physics, phase transitions, surface physics, physics of chemical and biochemical sensors, magnetic materials, transition metal oxides under extreme conditions, photonic crystals, and ultrafast nonlinear optics.
Theoretical research in the magnetic dynamics of spin clusters, macroscopic quantum tunneling, quantum nucleation, and Bloch oscillations in a metal ring.
General Relativity & Cosmology
The Tufts Institute of Cosmology is engaged in fundamental research relating to the origin and evolution of the universe, particularly in the areas of inflation, cosmic strings, and other topological defects. We are especially interested in the observational effects of defects, such as gravitational waves and high-energy cosmic rays. Group members also study general relativity and quantum field theory, in particular negative energy densities and quantum fluctuations of the vacuum.
High Energy
Experimental searches for neutrino oscillations, nucleon decay, Higgs boson and Supersymmetric particles. Studies of neutrino interactions, top quark, gauge bosons, particles with charm, strange and beauty quantum numbers in experiments involving fixed target beams, hadron-hadron colliders and deep underground tracking calorimeters.
Theoretical studies of quark dynamics, quantum chrom-dynamics, nucleon structure, polarization, gauge symmetries, spontaneous symmetry breaking, renormalization, soliton-meson systems.


text:
Good day to you, my reader! Since you have come up with this write up, I think it is safe to assume that you are looking for natural remedies for symptoms of menopause. With all the information that you can get in the Internet, I think you will be confused with what products really works and which do not. I wrote this article to give you a clearer view of the new product Amberen.
In this write up, you will know if Amberen is effective or not. Is it worth trusting and buying? This will also help you know what good effects Amberen will give you and at the same time, you will have an idea of the side effects that you may experience once you use this. Once you're done reading this write up, I am sure that you will be knowledgeable enough to decide for yourself if this is the product that you are looking for or not. So, let's get started.
>> To grab the best deal – Click here to buy at Amazon.com (cheapest price)
What is Amberen?
Most women, when they reach menopausal stage, they would get cranky and at times, they may feel that their life has been taken away from them. This is because of the menopausal symptoms that they encounter—night sweats, hot flashes, lack of energy. Most of the time, their loved ones shy away from them because they get too easily irritated and very moody. By taking Amberen supplements, all of these common menopausal symptoms can be alleviated. Yes, Amberen is your all-in-one remedy to menopausal symptoms. And what's best about this magic pill is that it is ver effective even if you just take low doses of it. You will just have to take 2 of these very little pills every day for 90 days and you'll be relieve with all the symptoms in an instant.
What are the Amberen Ingredients?
So, what is inside these pills? Amberen ingredients include Monosodium Glutamate, Calcium Disuccinate (good source of calcium), Magnesium disuccinate (for weight gain and mood swings), Ammonium succinate, Glycine (memory enhancer) and Zinc Disuccinate hydrate (for cramps). All of these fumarates and salts are made in a way that they will closely resemble the shapes that are bio-identical to our body. As a result, you can be sure that they will carry out a good and effective performance inside our body.
How does Amberen work?
It works by acting directly on the hypothalamus and the endocrine systme. It balances the two systems. Once this is done, it allows the body to produce its own hormones, just like what it is doing before menopause entered into the picture. As a result, the adrenal glands and ovaries can perform its given function—produce hormones and enzymes that will help releiev the symptoms.
View the video below for details on how the clinically proven Amberen works:
>> Click here to read more details and grab a discount!
Amberen Reviews
Is it effective? To show you how effective it can be, here are some Amberen reviews:
From women:
"I have lots of things to say about it. Thanks to this magic pill, I have been sleeping soundly at night with no leg cramps or any other distractions to disturb my sleep. Plus, I am very thankful that all my mood swings are gone. Now, me and my family can enjoy a fun time together."
From doctors:
"I have been in the medical field for way too long and I have met few women complaining about their menopausal symptoms. Me and my patients have already tried almost all the available supplements but to no avail, nothing really worked. This is the only supplement that have helped my patients go through their menopausal stage"
If you are interested in buying and using Amberen, then you must be aware that there are sites which sells fake pills out there. It is better that you be careful and ensure that the products that you will be buying are the original Amberen products.