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If Kitchenware Could Speak
weekly look into the world of electronic musics...
Beckett & Taylor
Let's Smash Up Our Love [12"]
[Soundslike, 2005]
If their kitchenware could speak, it would tell you it's been a long year and change since the last release 12" release from Beckett and Taylor. But despite their mini-disappearance, the duo have not only returned with another gem for their catalog with "Let's Smash Up Our Love," but also found an apt home on Matthew Herbert's concrete-house label, Soundslike. Steering clear of the rigidity of their more academic peers (Herbert and Soft Pink Truth), "Smash Up Our Love" explores the boundaries of recorded space in the most joyously cluttered manner possible. With both "Just Numbers" and "Don't Fret," the group plays a game of electro-acoustic pinball that is difficult to enjoy without an 8-year-old's grin. Sadly, the phoneme driven "Dumb us Down" is the only track that suffers on this 12," if only for not sounding as entirely different as the other songs. When my only criticism is a compliment in disguise, take this as a hint.
[Nate DeYoung]
DJ Kicks [CD]
It's an apt metaphor: on the !K7 website, the label is hawking a promotional scarf to accompany the release of Annie's newest DJ Kicks album. Problem is: it's made out of cotton, and looks for the world like it'd keep you warm only in the confines of, say, Misshapes on a Friday night. Annie's "DJ mix" will similarly make you look fashionable in a club full of people that enjoy nu-pop and its comfortable version of pleasure, but it'll never get you close to sweat. Save that for the professionals. Buy Alan Braxe & Friends' The Upper Cuts instead and get the only track worth hearing (released since 2000), plus a whole lot more.
Frank Martiniq
Extrashark [12"]
[Boxer, 2005]
"Extrashark"'s a deep tune seemingly built for the big room, with shades of shimmering trance chords that blast into the song mid-way through, only to be overtaken by huge swathes of white-noise that slide onto the sound field like waves. It's a mildly queasy track, but one that works beautifully. "Dumb De Luxe" rides in the same car of unfortunate and random noisiness, but is far too uncompromising in its backbeat to really grab. That is, until the whole thing gets interrupted by an analog bassline that leads to the crucial swing that it'd been missing. Recommended.
Helicopter Hearts [2x12"]
[Orac, 2005]
I haven't been as big a supporter of Orac as I want to be. The releases have all been good, but nothing's been knock-yr-socks off great. All that changes with Helicopter Hearts, which is the fully-formed jacking treat that I've been waiting for. The opener "My Helicopter Heart" and "Your Words Are Necessary" are two of the funkiest micro-sampled tracks not made by Marc Leclair, while follow-up "Baneful Leather" is a moody and deep house joint that, ahem, lathers you up for the climactic third side of "Dirty Hood" and "Cemento." Seek this one out, if you're a My Way fan.
Ricardo Villalobos
Achso [EP]
[Cadenza, 2005]
Only Ricardo Villalobos terms a four-track fifty-minute mind-melt an EP. That last hypenation, though, is the key. No mere 12" is going to actually melt minds. Sear it, maybe. Opener "Ichso" comes close—placing a bassline and murky echo pattern underneath two competing flamenco guitar (?) lines. "Duso" takes the beat up for its length, and pushes the melody far below the surface, instead focusing on the infinite possibilities created by miniscule droplets of watery delay. "Erso" reminds of little else besides Autechre's most recent excursions into complete abstraction while somehow maintaining an eye on the dance floor , while "Sieso" may be as close as he's come to another "Dexter" since its release. Is there a more fascinatingly dense artist working in dance music today?
[Todd Burns]
By: Stylus Staff
Published on: 2005-10-27
Comments (0)


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"What he did, especially to his teammate, is absolutely ridiculous," Jeff Gordon said.
Said Kevin Harvick, "It was good, hard racing, except for that chicken move under yellow."
They're referring to an incident on lap 71 that they considered to be a breach of racing ethics: Robby Gordon passed Harvick, his teammate, after officials had issued a yellow caution flag but before the two had crossed the start/finish line — a move that is technically legal under NASCAR rules but considered unethical among drivers.
When a caution flag is issued to slow the race after an accident, NASCAR rules say drivers are free to pass each other all the way up until the point where they pass the start/finish line. After they pass the line to "pick up the yellow," they must line up behind the pace car and maintain their positions.
Drivers, however, long ago established an unwritten "gentleman's agreement" not to race each other for position after the caution comes out. The reason: Trying to pass each other on the way back to a caution flag could be dangerous if there is debris or disabled cars on the track.
Jeff Gordon, who ended up finishing second, said Robby Gordon violated the gentleman's agreement, and was shocked that he did it to his teammate.
"That's just unheard of," Jeff Gordon said. "It doesn't surprise me, but it's unheard of in our sport."
Robby Gordon says he simply was following instructions issued by NASCAR officials during Sunday morning's driver meeting. Gordon said officials announced that drivers would be allowed to pass under yellow during Sunday's race, an edict Gordon found so strange that he interrupted the meeting three times to make sure he was hearing them correctly.
"I can't help it that I understood exactly what the rules were and took advantage of it," Robby Gordon said.
NASCAR officials, however, likely were referring only to so-called "local yellows," where a caution flag is issued only in one segment of the 11-turn road course. And Jeff Gordon's main complaint wasn't that Robby Gordon's move was illegal, he was complaining that it was unethical.
There has been bad blood between the Gordons, who are unrelated, since the last race of the 2001 season, when Robby bumped Jeff out of the way and went on to win at New Hampshire International Speedway.
"Do you really think I care what Jeff Gordon says?" Robby Gordon said. "He's won enough of these things, and I guess he doesn't like it when someone else rains on his parade."
Jeff Gordon said that if a teammate did the same thing to him, "I'm telling you what, we'd have us a little discussion somewhere."
"He's not big enough to have a 'discussion' with me," Robby Gordon responded.
As for Harvick, Robby Gordon said his move was payback for Harvick's attempted pass earlier in the race, on lap 58. When Harvick drove deep into the track's hairpin turn in an attempt to pass Robby Gordon, Ron Fellows passed them both to take the lead. Robby Gordon said he backed off while Harvick was trying to pass to avoid an accident.
Points leader Matt Kenseth cut a tire early in the race and came back to finish 14th — only his third finish outside the top 10 all season. Jeff Gordon's second-place finish, combined with Dale Earnhardt Jr.'s 11th-place finish, allowed Jeff Gordon to pass Earnhardt in the points. Gordon trails Kenseth by 174 points going into the last off weekend of the season.
Bill Elliott finished fourth, an impressive effort considering the fact that he was still in a cast from an accident last month where he broke his left foot.
"I've been nursing this foot along, and everything has gone well, but we needed this for the second half of the season. It'll give us the inspiration we need to get the second half started right. I need to get this foot better, but we had a good dependable car today."

subset: commoncrawl


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Project references


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A Justice Site
jeanne's schedule - Susan's classes - KID's Version
Previous Issue: Volume 14, No. 10 Week of October 28, 2002
Mirror Sites: CSUDH - Habermas - UWP - ARCHIVES
TOPICS INDEX - Concept Index - Vocabulary Index - SITE INDEX
Daily Site Additions - Site Stats - SITE MAP
Palestine Monitor - Ha Aretz - Anti-War News
Free Congress Foundation on Conservative Governance
California State University, Dominguez Hills
University of Wisconsin, Parkside
Soka University Japan, Transcend Art and Peace
Latest Update: November 2, 2002
What Elephant?
What Elephant?
This week's story matters a whole lot to me. The elephant is one I met in Thailand, Chiangmai, to be exact, at the Masa Elephant Camp. I have a photo of us riding her (him?) And the photo is a lot about denial. I know the elephant is really pink in denial paintings, but this one was just elephant-colored. So I gave her pink polka dots. That should do. And her story is so very sad. They no longer need her in Thailand to do the heavy construction, so there's nothing left for her to earn a living, but to ask tourists to go for a ride on her back. Exciting, yes? But ever so sad, when we realize that she, and all the people who once worked with her are now no longer needed in the "productive economy" of Thailand. That's the pink part - the dots of DENIAL, that manage to overlook the harm we cause to Others, and the extent to which we DENY that harm.
This week: States of Denial by Stanley Cohen. Polity Press. 2001. Think AWARE.
* * *
Merriam-Webster Dictionary Search:
NEW for the Week of October 28, 2002
Powerful poem on war and killing and who we are. War and the Killing of Our Sons. Link added November 7, 2002.
Weekly Schedule: I DID IT! I DID IT! I DID IT! Well, Almost. I'm Doing It.
Well, I almost did it. At least I got started, and I was on the right track. I need MORE TIME!
Grades and End of Semester:
Records of Learning Just started to update them. Many comments still to go up. jeanne Please be sure to e-mail me and/or come in to see me this week so that you do not need to worry about grades while I'm in Chicago. jeanne
Health: Check out Chana Dal and Help with Diabetes
- Hunger No. 1 Health Problem in World Backup.
- Living Wage Issue Put in Voters' Laps By Martha Groves. "The measure on the Santa Monica ballot will culminate a years-long battle over mandating a base pay for workers in the city's tourism zone." P. B 1. October 31, 2002. Los Angeles Times. California Section. Backup. These are the "unseen" others we choose not to hear about. Take the time to read the story. Then think on the importance of stories to social justice.
Tami Chappell for The New York Times
"Kristin McKenna considered going to college in California before receiving a merit scholarship at the University of Georgia, and a car."
- B's, Not Need, Are Enough for Some State Scholarships By Greg Winter. New York Times. P. A 1. October 31, 2002. Backup.
Hiromi Yasui for The New York Times.
"Recent attacks on girls' schools in Afghanistan, as well as an anonymous letter, appear to confirm that Islamic militants have begun a campaign against the education of girls."
- Attacks on Schools for Girls Hint at Lingering Split in Afghanistan By David Rohde. New York Times. P. A 1. October 31, 2002. Backup.
- Elder Abuse Law November issue of the Daily Journal, Los Angeles' Legal Newspaper. Backup.
Perspectives on Evil and Human Wickedness Conference
20 to 25 March 2003, Anglo-American College
Prague, Czech Republic
New conference possibility: I expect that this will tie in with our work on denial and forgiveness. My only concern is that they have taken the path of personifying Evil. I prefer the concept that evil may be an absence of good. Perspective. Perspective. I've already written for information. Their website is Wickedness.net. We need to recall that many times words take on a life of their own. For some reason, such emphasis on "evil" and "wickedness" transport me almost instantly to medieval torture and witch hunts and the Inquisition. And I panic. My own nervous system seems to require more peace and centering than such an orientation provides. I do know that Satanic cults are alleged to exist; I do know that "evidence of some sort" does exist; but it all freaks me out. That doesn't mean that I have to deny it's existence. It does mean that I'm a pretty poor person for detecting more evidence, for interpreting that evidence, and for being a spokesperson for people who have come into contact with Satanic cults. I put aside my squeamishness enough tonight to write to the person in charge. Perhaps it's just the words. Or perhaps, here, too, I may not be the right person to deal with this group. At any event, I'll make it a practice to stay away from their title, and I will recognize that just because they're talking about the obverse of my concerns doesn't mean we don't have anything to say to each other.
Index on Comments
New Comments, not yet Indexed Link added October 20, 2002. Will try to update this weekend, but the flu might win. jeanne Oct. 31, 2002.
American Society of Criminology Annual Conference
Chicago, Tuesday, November 12 through Saturday, November 16.
We have two sessions on Thursday and two on Saturday. Susan had the Wednesday session changed. Check the conference schedule for times.
Theoretical Musings for Us by Us
Lived Experience: Emancipatory Narratives
Some of the comments from this article that might catch your attention:
So what are the limits on rap, and similar genres? Is it wrong? Period. Even to fantasize it? Where does fantasy begin and life leave off? Do our kids know the difference? Can you prohibit fantasy? Do you want to?
What does it say to us that such race crossovers are possible? Does it matter whether the story of his life that Eminem tells is true? What is truth?
What does all this tell us about criminology and the definition of crime? When men and boys and women and girls are locked totally away from the rest of the population, are their lives about fantasy or about reality? How do those two interact? What happens if society so distances you from your lived reality that only fantasy beckons? Is there a way to recapture reality one day? These are some of the deeper questions we haven't asked frequently enough of prisoners and those who manage them, and of our children and ourselves who manage the children.
Art Shenanigans
- What role do color, line, form, outline play in evoking a response from this photo? We'll discuss this aspect of art in social theory and culture next week. jeanne Link added November 2, 2002.
late capitalism running after commodification
- Now, what on earth do you suppose I meant by this painting and title? Well, actually I drew it in a fun-filled moment at Art's Deli when my brother-in-law hadn't quite decided on whether he just didn't want to eat, or while he was checking out the quality of the corned beef, or when he was finally sitting down long enough to tell the waitress (who had graciously come by three times) hat she didn't know what she was doing, since after all, she wasn't from New York. Gee, I bet that surprised her!. It seemed like a good time to draw. And, needless to say commodification came to mind, and all the complaints that go with it. Then I thought how we couldn't get my brother-in-law to sit still for more than two minutes at a time, how I kept trying to crawl under the table with my pet cheetah, and my husband's look of absolute dismay because he couldn't think where he should run. Suddenly, I got it. It was funny. There we all were, properly shepherded by Pat. Oops, no, Pat wasn't there that night. Well, so we were unchaperoned, and probably running in more directions than our family of cats, while my brother-in-law complained that it wasn't Cantor's. We have a word for this in Yiddish: OY !!!!
- Sample Contents: Fireworks over the Statue of Liberty Link sent by Elise Zevitz, on Friday, November 1, 2002. Thanks, Elise.
Scholarly Resources
- Everything Postmodern I like the site. There's even some interesting questions addressed, and some plausible answers given. Link added November 5, 2002.
- Seville Statement on Violence Spain, 1986. UNESCO site. Be sure to take the time to browse on this human rights site. Link added November 4, 2002.
- African Studies Association Links Page Link added October 28, 2002.
- And How to Concept Link to Get an A. Fixed a link and checked link on September 30, 2002.
- Sample Contents: Virtual Faculty"Our delineation of the subject matter of psychology has to take account of discourses, significations, subjectivities, and positionings, for it is in these that psychological phenomena actually exist. For example, an attitude should not be seen as a semipermanent mental entity, causing people to say and do certain things. Rather, it comes into existence in displays expressive of decisions and judgements and in the performance of actions. Each reconceptualization helps to draw attention to the fact that the study of the mind is a way of understanding the phenomena that arise when different sociocultural discourses are integrated within an identifiable human individual situated in relation to those discourses. (Harré and Gillet, 1994: 22)."
Institute of International Studies University of California, Berkeley. Link added October 16, 2002.
Classes, Workshops, and Lifelong Learning
Let's have a Chana Dal Workshop and a Menopause Workshopwhen we get back from Chicago. And don't forget our Peace March and our Financial Aid March, for which there's a new article up on merit scholarships. Maybe one of these shoudl be a town forum. jeanne
Classes and Lifetime Learning
- Records of Learning Just started to update them. Many comments still to go up. jeanne Please be sure to e-mail me and/or come in to see me this week so that you do not need to worry about grades while I'm in Chicago. jeanne
- Lecture Notes: September 24, 2002 On Illocutionary Force. Link added September 24, 2002.
- Lecture Notes: September 25, 2002 Illocutionary Discourse on Teaching for Peace and Social Justice. Link added September 25, 2002.
- Lecture Notes: September 25, 2002. Research for a Cure? Or Acceptance and Comfort? Christopher Reeves. Link added September 25, 2002.
- Comments on Recent Lectures: September 25, 2002. Link added September 25, 2002. Reference:
- Comments Index by Topic Link added September 25, 2002.
- Site Map
- Finding Stuff
Plausible Reading and Study for Week 5:
Not up yet. I was dreaming. Learning Records took all weekend. jeanne
- Soc 334: Women in Society
- Soc 367: Sociology of Law
- Soc 370: Moot Court and Social Justice
- Soc 595: ReInterpreting Theory
- A Sample of Inadvertent Possible Plagiarism! URGENT that you read!
Thesis Projects
- Essays on Thesis Praxis
Reference Essays:
- Pulling It Together How to get started writing once you've done your research. From Pat Acone's thesis project: Collaborative Writing in Online Education. Link added August 16, 2002.
- Getting Started How to recognize what you've really been doing when you thought you were trying to do something else. Berthena Kemp's thesis project: Our African Heritage. Link added August 16, 2002.
- Recharging Along the Way Millie Coulter has thought of changing topics frequently. Not because she doesn't want to write on her topic, but because barriers, institutional barriers, keep getting in her way. This is the problem of finding your authentic self in writing your thesis. How do you make the thesis fit you in spite of external institutional constraints? Lin to be added August 18, 2002.
- Through Hot Pink Glasses: Fat Is Fun
Link added August 16, 2002. This piece will fit into Millie Coulter's thesis project. Link added August 17, 2002.
- Alcohol and Aging In response to student requests for our Fall workshop on alcohol abuse and domestic violence. Link added August 21.
- Menopause: from Sex, Gender, and Menopause Workshop In response to Agnes' request for our Fall 2002 workshop. Link added August 18, 2002.
Evaluation of Site Teaching Practices
- Reference:
- Index of Site Teaching Modules
With teaching essays, analyses of texts, discussion questions, field activities, and self tests.
- Module List Each essay or article paired with its Practice Module. Notation clarifies when Practice Module not yet uploaded.
Navigating the Site
On-Going Project Evaluation
- Interim Evaluation Report on the Dear Habermas Project The interim report is offered so that students can look at the evaluation design and have meaningful input for the Spring 2002 Evaluation.
- Student Evaluation Form Not up yet.


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Walmart is having a special promotion where you can get a holiday dinner to feed a family of 8 people for less than $30!
The dinner includes the following
*10 lb select, hickory smoked, spiral-sliced ham
*six 11-15.5 oz cans of Del Monte vegetables
*one 12 ct package of dinner rolls
*one 10 lb bag of russet potatoes
*one 10″ Pumpkin Pie
Check out their press release about the promotion. If this isn't your thing and you're in a financial position to do so, please consider purchasing one (or more) of these dinners and donating to your local food bank or food pantry to help the hungry in your own communities.
Check out HOT Amazon deals on your favorite items!


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The minor in conflict and mediation studies provides conceptual, practical and applied knowledge in mediation and conflict management. The program is intended for students not majoring in speech communication who wish to supplement and augment their major area of study. The requirements for a conflict and mediation studies minor are 21 credit hours, 18 hours required and three optional hours, as indicated.
To view the Conflict Analysis & Intervention webpage click here.


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Gene Therapy for Ovarian Cancer
Gene Therapy for Ovarian Cancer
The recent advances in cell and molecular biology of cancer
have elucidated some of the mechanisms underlying malignant transformation,
tumor cell migration, metastasis, angiogenesis, and cell response to
chemotherapy. Advances in molecular virology and biotechnology have allowed for
the engineering of vectors that can efficiently transfer genes to target cells.
As a result, gene therapy strategies for the treatment of cancer were developed
along two fundamental directions. Cytotoxic or suicide gene therapy approaches
entail the transfer of genes that encode enzymes able to convert inactive
prodrugs into cytotoxic drugs. Only transfected cancer cells expressing the
specific enzyme become susceptible to killing. Corrective gene therapy
strategies aim at repairing specific molecular alterations occurring in signal
transduction mechanisms that control the cell cycle or induce apoptosis.
Gene Therapy Vectors
The Recombinant DNA Advisory Committee has approved hundreds of gene therapy
protocols for the treatment of genetic diseases or cancer. Although gene therapy
strategies have produced highly promising results in preclinical in vitro and
animal models, their application in clinical practice has proven to be much more
difficult. A fundamental problem concerns the efficiency of gene transfer. Viral
vectors remain the vectors of choice, mainly because of their high efficiency of
transfection. After all, viruses have evolved successful strategies for
introducing their genome into eukaryotic cells and using the host cell
biochemical machinery.
The vast majority of phase I trials employ viral vectors, but some use DNA
protein complexes, DNA particles, ribozymes, or lipid-based vehicles. To
minimize side effects, viral vectors are rendered replication-incompetent. To
date, several vectors have been developed that are associated with significant
limitations related to low efficacy, inability to penetrate deeply in tumor
nodules, inactivation by the immune system, and undesired side effects (Table
1). To enhance efficacy, inserted genes (transgenes) are positioned under the
control of a strong exogenous promoter. A reporter gene, such as the Escherichia
coli LacZ gene encoding beta-galactosidase, is also inserted to assess the
efficacy of gene transduction.
Adenoviral vectors are currently the vectors of choice in gene therapy,
including cancer gene therapy.[1] Adenoviral vectors are remarkably efficient,
but yield only transient expression of therapeutic genes and are generally
administered repeatedly to lengthen the duration of gene expression.
Adenoviruses infect dividing and nondividing cells, and can be produced
relatively easily on a large scale. They are stable, may be manufactured without
contamination by replication-competent adenovirus (RCA),[2] and can accommodate
up to 7.5-kb transcripts. Backbones have been derived from Ad2 and Ad5 serotypes,
both of which belong to the wild-type-C adenovirus subgroup.
The vitronectin receptor alpha(v) beta(3) integrin and the coxsackie/adenovirus
receptor mediate virus entry into human cells through chlathrin-coated
vesicles.[3] The viral genome remains extrachromosomal in the nucleus.
Recombinant adenovirus is produced on appropriate packaging cell lines
complementing the missing genes. The early genesspecifically, E1were first
targeted because they control viral replication and regulate the expression of
late genes. Substitution of E1A and E1B genes by a designated transgene led to
the creation of the first generation of adenoviral vectors.
Due to the high likelihood of recombination events occurring during
manufacturing in vitro, engineering of strains lacking only one gene were
characterized by a prohibitive degree of replication-competent adenovirus (RCA)
contamination. This translated to high toxicity, particularly hepatotoxicity,
considering the elevated liver tropism of the wild-type virus. A
second-generation virus was then produced by adding an additional mutation in
the E2A or E3 regions.[4] This improved the toxicity profile of the vectors by
dramatically decreasing RCA contamination.
Administration of adenovirus is followed by an intense inflammatory and
immune response. An early innate response consists of the release of
inflammatory cytokines such as interferon (IFN)-gamma, interleukin (IL)-1, and
IL-6 as well as the recruitment of an acute inflammatory infiltrate followed by
a specific neutralizing antibody and T-cell response.[5] Both the transgene and
viral genes expressed by transfected cells are cross-presented on major
histocompatibility complex (MHC) class I or II sites, triggering specific CD8-
and CD4-positive T cells. An intense inflammatory reaction in proximity to the
tumor may enhance tumor immune recognition. However, immune-mediated vector
neutralization may pose marked limitations on the transduction efficacy of the
We and others have recently demonstrated the presence of neutralizing
antibodies in the serum and peritoneal fluid of patients with epithelial ovarian
cancer that significantly decrease the efficacy of adenoviral vectors in vitro.
However, the presence of antiadenoviral antibody titers did not appear to
compromise the efficiency of gene transfer in a phase I trial of
adenoviral-based gene therapy for pleural mesothelioma conducted at our
institution.[6] Nevertheless, there is still considerable concern about the
limitations posed by the immune system, particularly if repeated administrations
of vectors are planned. A third-generation adenoviral vector with somewhat
decreased immunogenicity was recently produced by the deletion of the E4 region
(in addition to E1 region) and preservation of the E3 region. The protein
product of E3 inhibits MHC I transport to the cell surface, thereby preventing
immune recognition of adenovirus-infected cells.
To address the concerns of RCA contamination and immune-mediated response,
"gutted" or "gutless" adenovirus vectors that contain no
viral genes have been generated.[7] These vectors accept up to 38 kb of foreign
DNA. Gutless adenovirus vectors are replication-deficient and require helper
viruses for propagation. One advantage of gutless vectors is that they are less
immunogenic and, by using helper viruses derived from different adenovirus
serotypes, production of host antibodies can be directed away from the
therapeutic gutless vector. Gutless adenovirus vectors are showing promise in
gene therapy. In mice, sustained expression of transgene was seen after a single
injection, with no serious virus-associated toxicity.[8]
Epithelial ovarian cancer cells are susceptible to infection by adenoviral
vectors.[9] We recently demonstrated that an E1/E4-deleted adenovirus was
similarly efficacious to an E1/E3-deleted one in several epithelial ovarian
cancer cell lines (unpublished observation). Current investigation is focusing
on improving the tissue selectivity of adenoviral vectors. Crosslinking of
adenoviral particles to basic fibroblast growth factor has proven to
significantly increase the binding of adenovirus on epithelial ovarian cancer
cells (SKOV3.ip), resulting in a 10-fold enhancement of its efficacy in
vitro.[10] Furthermore, the incorporation of an Arg-Gly-Asp (RGD)-containing
peptide to the HI loop of the adenovirus fiber knob through genetic engineering
directs the virus away from coxsackie/adenovirus receptor binding sites and
enhances its binding to the ovarian cancer cell surface.[11]
Adeno-Associated Virus
Adeno-associated virus has a 4.7-kb single-stranded DNA genome surrounded by a protein coat. Adeno-associated
virus is not autonomous; in the absence of a helper virus, adeno-associated
virus enters a latent state of infection, while coinfection by an adenovirus or
herpesvirus enables adeno-associated virus to replicate.[12] Its genome has at
least six transcripts with three internal promoters and two inverted terminal
repeats. Construction of recombinant adeno-associated virus vectors can be
accomplished by stripping off the gene sequences encoding viral structural
proteins and generating a backbone with the two inverted-terminal repeats
surrounding the inserted transgene. A packaging cell line is necessary for viral
replication and production.
Wild-type virus integrates at a specific site on human chromosome 19. Adeno-associated
virus vectors also integrate into host DNA for sustained gene expression. Adeno-associated
virus proteins are not toxic to cells. Although 80% of the population is
seropositive, adeno-associated virus is not associated with any known disease in
humans, and an existing immune response does not impair the efficiency of
transfection. Moreover, adeno-associated virus infection is not accompanied by
inflammation or generation of a strong recall immune response.[13]
Adeno-associated virus shows promise in the setting of gene therapy because
it infects a wide variety of cells. Its ability to infect both dividing and
nondividing cells may be a major advantage in targeting tumors with low
S phase. Sustained expression from adeno-associated virus vectors has been
observed in several tissue types. Epithelial ovarian cancer cells harvested
directly from patients are susceptible to infection by adeno-associated virus,
making adeno-associated virus a promising vector for further testing in cancer
gene and immune gene therapy of this disease in particular.


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Wellington Classic Estates (WCE) is an exclusive fully platted equestrian sub-division located in Wellington's prestigious Equestrian Preserve. The location is just over one mile south of the Palm Beach International Equestrian Center, home to the Winter Equestrian Festival. The Property's entire southern border is the Loxahatchee Wildlife Conservation Area, an environmentally protected wetland. Encompassing approximately 49 gross acres, WCE is substantially improved with a gated entrance, paved internal roads, Underground power,internal water management system; all benefiting the 10 individually platted lots contained in the community. All individual lots are filled to grade and in ready to build condition.
- List Price
- $1,117,500
- Subdivision
- Wellington Classic Estates
Here is the estimated breakdown for this property's mortgage and tax payments. Feel free to adjust any of the values.
Results received from this calculator are designed for comparative purposes only, and accuracy is not guaranteed.
Listing courtesy of Equestrian Sotheby's International Realty
DISCLAIMER: The written and verbal information provided including but not limited to prices, measurements, square footages, lot sizes, calculations and statistics have been obtained and conveyed from third parties such as the applicable Multiple Listing Service Internet Data Exchange ("IDX"), public records as well as other sources. All information including that produced by the Sellers or Listing Company are subject to errors, omissions or changes without notice and should be independently verified by any prospect for the purchase of a Property. The Sellers and Listing Company expressly disclaim any warranty or representation regarding all information. Prospective purchasers' use of this or any written and verbal information is acknowledgement of this disclaimer and that Prospects shall perform their own due diligence. Prospective purchasers shall not rely on any written or verbal information provided when entering into a contract for sale and purchase. Some affiliations may not be applicable to certain geographic areas. This information is not verified for authenticity or accuracy and is not guaranteed. The information provided is for consumers personal, non-commercial use and may not be used for any purpose other than to identify prospective properties for purchasing. Some properties which appear for sale on this web site may subsequently have sold or may no longer be available. Please contact Premier Estate Properties directly for additional information pertaining to the status and availability of properties displayed on this website. All listings featuring the BMLS logo are provided by BeachesMLS Inc. This information is not verified for authenticity or accuracy and is not guaranteed. Copyright 2017 Beaches Multiple Listing Service, Inc.


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Wedding Party Plunges Into Lake as Dock Collapses [VIDEO]
It's a nice day for a WET WEDDING!
Who thought it would be a good idea to line up a wedding party of 22 people on a dock, in order to get a couple of photos? We're guessing it was one of the three bridesmaids on the far right — the only ones who managed to stay completely dry when the dock collapsed.
Despite the plunge into the Minnesota lake, Dan and Jackie Anderson's wedding only started 10 minutes late, according to USA Today.
– George McIntyre
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Home | Senior Services | Delaware | Rehoboth Beach
Find the best senior services in Rehoboth Beach quick and easy. Use our comprehensive search directories to get company and contact information for senior services providers in your area. Compare services and prices before deciding which provider is the best fit for you. Browse the listings below to find reliable, affordable senior services in Rehoboth Beach, Delaware.


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4 bedroom villa for sale
Spain - Javea, Alicante, Valencia
like this property?Call: 03339 390730
Key features:
- Spain
- Costa Blanca
- Javea
- Villa
- Beach
- Balcon al mar
- Sea views
- pool
- First line of the beach
Full description:
Two-storey villa in a traditional Spanish-style "rustic" with a panoramic view of the sea, islands and mountains in one of the greenest areas of the coast - Balcony Sea. Neighborhood raised by about 100 -300 meters above sea level and is surrounded by pine and eucalyptus trees. The unique microclimate.The villa is suitable private road. The place where the villa is a nature reserve and further construction in the area is prohibited. To the sea are the steps. The villa is only visible from the sea.Main floor: living room with fireplace, access to the terrace, open kitchen, guest toilet, bedroom and bathroom.Ground floor: living room, 3 bedrooms, 2 bathrooms.A unique opportunity to buy a villa on 1 line in reserve!
Plot size: 1 200
Housing area: 200
Javea, a city that deserves your attention.
Javea (in the Valencian language Xabia) is a small, charming Spanish resort on the north coast of the province of Alicante, Costa Blanca. Located 90 km from the island of Ibiza, 92 km from Alicante and 110 km from Valencia. Valencia and Alicante both host international airports.
The AP-7 (Motorway) will help you to get from the airport to the city in approximately one hour ("Autopista del Meditarráneo", Exit 62). Regular bus services will take you to the centre of Valencia, Alicante, Madrid and Barcelona, as well as the nearby towns of the coast.
Covering an area of 68.59 km ², according to the latest census conducted in 2012, has a population of 32,983 inhabitants, of which 53.1% are foreign nationals. The population increases to 150 000 people in the summer season.
The Montgo Mountain, with a height of 753 m., Is the area's most remarkable natural protector, which protects the town from the northern winds, supporting the unique local microclimate.
The region is host to capes such as "Cabo de la Nao", "Black Cape" and "San Martin", 2 small islands (Portichol and Descubridor), natural coves and beaches "Ambolo" and "Granadella" which have beautiful clean water. A true gift of nature that is necessary to visit and enjoy with beautiful panoramic views which can only be seen here.
Columbus, a navigator and local resident, said that there are only two beautiful places in the world. First being Javea, and the second, Rio de Janeiro.
The official languages are Spanish and Valencian. English is the most common foreign language, as Javea is one of the largest colony of English on the coast, 6 000 people. German is the second foreign language (about 2000 inhabitants), well ahead of the Dutch and the French, Italian and Russian. 85 nationalities live in this wonderful town, creating a special cosmopolitan atmosphere.
According to a study conducted with 90 years of research, the city is considered the second best for its microclimate in the world, after Rio de Janeiro. You can enjoy a pleasant temperature throughout the year, on average range from 18º to 24º. Proof of which is the fact that Javea is the chosen place of summer residence for both foreigners and national alike. Green is the dominant colour of the landscape. The city literally immersed in the pines trees that descend to the sea.
Javea is the first city mentioned in the chronicles of King Jaime II, due to the need of strengthening the southern lands, since the beginning of the XIV century the area has been marked by two conflicts: the 1296 war of Castile and the raids of the Moors from Granada (1304-1308).
In 1397 Javea became a city with its own council, but remains part of "marquesado de Denia".
In 1877 the gothic church of st. Bartolomé was constructed, this being the current epicentre of the city. Today characterizes Jávea with its whitewashed houses, iron trellises and lintels worked in a porous golden land called "tosca".
Javea Port had received concession for exports and imports of goods and fruit. This, combined with the natural bay protected from storms, led to the fact that the port has become the trigger of the local economy, especially on the import of wheat and then trade raisins. The economy of the population was based on rain fed crops: wheat, almonds, vines, carob and olive. Own production and import of wheat from Sicily led to the construction of mills.
Since the second half of the nineteenth century, the production, processing and export of raisins will become the engine of modernization, thanks to a strong increase in demand in the US markets, which lead to the emergence of local commercial bourgeoisie.
In the twentieth century, since the 60s, Javea has become an equal with Palma de Mallorca and Marbella for its prestige in elite tourism.
The fishing industry is still a valuable source of income, largely thanks to the natural harbour of the "Cabo de san Antonio". Javea has its own auction (Lonja), where fishermen sell freshly caught seafood.
Monuments and places of interest:
The most significant monument is the church of St. Bartholomew in the centre of the city. This church dates back to the XVI century. Its bell tower can be seen from anywhere in the city.
In order to protect the city from approaching pirates several towers were built along the coast, which served as lookouts. The city currently preserves 2 watch towers in excellent condition, one of which is located in Portitxol, and the other in Ambolo and is privately owned (closed to visitors).
The Church of "La Virgen del Loreto", is also a city monument but is constructed in a more modern style, made of materials of the old church port. This modern church is unique in its dome, like a keel boat. And if you climb the hill of San Antonio, you will see that the exterior columns remind you of an octopus.
On the smooth plane going towards the "cabo de San Antonio" you can find the monastery of the "Virgen de los Ángeles", a monastery of the order of the "Jerónimos" and run by a single monk who takes upon himself to give mass, weddings and takes communions.
You can also find, "Los Molinos", windmills from the fourteenth century and the Montgo Nature Reserve.
Nearest Airports*
- Alicante (International), 55.3 miles
- Valencia (International), 59.7 miles
- Ibiza/San José (International), 64.3 miles
- Murcia-San Javier (International), 88.5 miles
*Distances are straight line measurements. This feature is currently in beta.


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202 South Allen Street
State College, PA 16801
Store Local: 814-237-3655
Store Toll-Free: 800-993-8697
Online Customer Support: 800-372-9982
We're excited to offer these educational games and activities from Patch Toys! Serving up awesome travel games and party activities for over 40 years, they really know how to make every occasion more fun! Check out their magnetic games that let kids (and adults!) play on a road trip, on a plane, or anytime the assistance of magnets makes playtime easier. You will find other ways to play too - so have fun!
Site Map © 2017 GROWING TREE TOYS


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How concerned is the White House over Chuck Hagel's confirmation chances? Enough to have him produce a written apology for the most inflammatory of his comments well ahead of his first hearing. In a letter to Senator Barbara Boxer (D-CA), Hagel expressed regret for referring to a "Jewish lobby," claiming he only did so once:
Former Sen. Chuck Hagel (R-Neb.), President Obama's pick for Defense secretary, expressed regret for a past comment about the "Jewish lobby" which has threatened to derail his nomination.
In a letter to Sen. Barbara Boxer (D-Calif.), released Monday, Hagel called the remark a "poor choice of words," and vowed that he would work to "expand the depth and breadth of U.S.-Israel cooperation" if confirmed for the Pentagon's top post.
"I regret saying it," Hagel wrote. "I used that terminology only once, in an interview. I recognize that this kind of language can be construed as anti-lsrael. I know the pro-Israel lobby is comprised of both Jewish and non-Jewish Americans." …
"In the Senate, I was a strong supporter of Defense appropriations, which provided enduring support for Israel's security. Most Americans, myself included, are overwhelmingly supportive of a strong U.S.-Israel strategic and security relationship. This broad support comes-from both Jews and non-Jews alike," said Hagel.
Claiming this as a one-off could end up backfiring on Hagel. It certainly might have been a one-time stumble, but Hagel and the White House had better hope it's true, or that any other repetitions happened outside of the range of a live microphone. Otherwise, they're looking at a Mark Fuhrman scenario, and a public-relations disaster if more of these kinds of comments come to light.
The letter is curious, too, for its intended recipient. Why send it to Barbara Boxer? She's hardly the point person for Democrats on Hagel; that's Chuck Schumer, whose decision will make or break Hagel's nomination. Carl Levin would have been the most appropriate correspondent, as chair of the Armed Services Committee, or Richard Blumenthal, who sits on the committee and sounded as though he was looking for a reason to support Hagel on Sunday. Boxer, who chairs Environment and Public Works and sits on Foreign Relations, won't get a vote on Hagel in committee, and no one would seriously have thought she would oppose an Obama nominee in the first place.
On Iran, Hagel insists that he's a get-along-to-go-along kind of guy:
"I agree that with Iran's continued rejection of diplomatic overtures, further effective sanctions – both multilateral and unilateral – may be necessary and I will support the President," said Hagel.
"I have always been supportive of a strong U.S.-Israel strategic relationship and always supported Israel's right to defend itself against attack," he added.
This is the more important issue, and Hagel's record speaks for itself. He staunchly opposed efforts to impose these sanctions on Iran in the first place, opposed efforts to designate the Islamic Revolutionary Guard a terrorist organization based on its support (financial and otherwise) of terrorist networks, and claimed in Pakistan in 2008 that the military options for the US and Israel to stop Iran from nuclear-weapons capability were irrational and unrealistic. That puts Hagel on the fringe of both parties, and sends a curious message of indifference to Iran at a critical time in their pursuit of nuclear weapons.
The letter might help Hagel gain more enthusiasm among Democrats already looking to support him, but it's not clear at all that it will dent the skepticism among those who aren't.
Update: Apparently, the letter was good enough for Schumer:
Sen. Charles E. Schumer (D-N.Y.) announced his support Tuesday for the nomination of former senator Chuck Hagel as Secretary of Defense, delivering a key vote for the Nebraska Republican's confirmation after weeks of voicing doubt about his positions on security issues related to Israel and Iran.
Schumer, the No. 3 Democrat and most senior Jewish senator, made the decision following a 90-minute meeting Monday in the West Wing, a secretive huddle that Schumer and White House officials kept under wraps until the decision to announce his support today.
"Senator Hagel could not have been more forthcoming and sincere," Schumer said Tuesday in a statement. "Based on several key assurances provided by Senator Hagel, I am currently prepared to vote for his confirmation. I encourage my Senate colleagues who have shared my previous concerns to also support him."
That should settle the matter … assuming there are no other surprises.


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Symmetry in design captures the essence of the Elle collection. Graceful sweeping arms finished in chrome support a contrasting frosted glass. The perfect addition to contemporary bathroom decor. Xenon lamp supply a bright, natural light.
Founded in 1970 in a California garage, Maxim Lighting has grown into a lighting leader known for its high standards in quality and design innovation. Offering a wide selection of elegant fixtures as well as specialty items such as under cabinet and party lights, the company imparts the family-run values of hard work and earned loyalty into every lasting design it creates.
Our team has over 100 years combined experience with contemporary lighting.
Every EuroStyleLighting.com order is backed by our 100% Satisfaction Pledge.
Shipping and Delivery Information - For item EUT2243 if ordered by 1 pm Pacific Time


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Get together in Amphipôle 249 for a soup prepared by the chaplains. Don't forget to bring your pic-nic and enjoy meeting new people and making new friends.
Help once in a while with the dishes.
For those who have time, stay and chat over coffee or tea.
No signing-up, just come when you want and pay the cost of the food.


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Best Boats 2012 Winner: The Com-Pac CP 23 Pilothouse
"It's bright and livable, and as adorable as a Teddy bear"
Among the many large, expensive sailing vessels at this year's Annapolis show, the crowd-stopper was this diminutive 23-footer with a tall pilothouse. Something about it—perhaps the proportions, perhaps the novelty, perhaps the accessibility— made people pause, do double takes and smile. It was a memory of childhood books about Little Toot the tugboat or the persistent dream of cruising away to quiet coves with the one you love that caught their attention.
Stepping aboard the Com-Pac 23 Pilothouse reinforced all those feelings. That pilothouse has headroom for a six-footer and windows that let you see all around even while sitting at the cute two-person dinette. The V-berth forward is as big as that on a 35-footer. There's even an enclosed head with a sink. A 12-horsepower diesel huddles under the cabin step. It's bright and livable, and as adorable as a Teddy bear.
The detailing is as clever as the overall design. The mirror in the head drops down to give visibility aft from the inside helm. The dinette table is cantilevered for legroom, can be removed to form a filler for a berth, and is strong enough to support a man's weight. When the weather is fine and you want to sail from the cockpit, the nicely engineered linkage between the inside wheel and the tiller can be disconnected to improve the responsiveness of the boat underway.
Com-Pac has a reputation for strongly built boats with neatly executed details, and this prototype was a work in progress. The builder is enthusiastically coming up with even more neat touches, and the production models that come from the factory this winter should be finished better as well. The hull is the company's standard 23-footer, whose shoal keel and large volume make the pilothouse version possible.
For more information, visit www.com-pacyachts.com.
|23ft 11in
|20ft 2in
|7ft 10in
|2ft 3in
|3,500 lb
|1,340 lb
|Sail Area
|240 ft2


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Inland Northwest Community Foundation works closely with nonprofit organizations and others throughout the region to identify and respond to a wide range of community issues and opportunities. This might be as complex as collaborating with community leaders on a long-range plan for neighborhood preservation, or as basic as funding a program to provide shoes for children from low-income families. In all cases, INWCF looks to fund solutions that will create measurable, positive change in our region.
Application to all of INWCF's grant programs is made through an online process. Before beginning the application process, please review the guidelines for the specific program to which you are considering applying.
If you have questions about any of INWCF's grant programs, please contact our grants program staff.


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White Wine Selection
Yalumba Eden Valley Viognier 2015
Yalumba Eden Valley Viognier is a apricot nectar, lifted honeysuckle and orange oil-tinted apricot bomb.
Villa Wolf Dry Riesling 2014Made by Pfalz master Dr Loosen, Villa Wolf is crisp and balanced, with delicate flavours of peach, wrapped up in a cool mineral cloak.
Loimer Langenlois Kamptal Gruner Veltliner 2015
Gruner Veltliner, classically-styled yet brazenly delicious,
Welcome to our white wine shop. As well as plentiful Chardonnays, much-loved Sauvignon Blanc from Marlborough, New Zealand and some terrific Rieslings, we hope your interest will also be peaked by some of our less well-known varieties of white wine. Why not try one of our award-winning Portuguese wines, the almost unheard of Verdil from Valencia, or Assyrtiko, grown on the volcanic Greek island, Santorini? There is also a strong offering from Australia and South Africa so, whatever your white wine preferences, we are confident you will find something here. To help narrow your search from nearly forty varieties of white wine from across the globe, use our 'Refine By' tools to either select a particular grape or filter our white wine selection by country, price and the wine's characteristics. If you still can't decide or would simply like some help, please give us a call or drop us an e-mail where one of the friendly souls at Oddbins will be more than happy to help.
Gaia Notios White 2014£12.75
In stockMoschofilero (50%), Roditis (50%)2Light Full bodied3Dry Sweet


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A cursory scan of the crowd at David Brockhoff's memorial service at St Andrew's College, Sydney University, on Friday revealed why the Waratahs were always going to struggle against the Blues.
Berrick Barnes, Al Baxter, Daniel Halangahu, Wycliff Palu, Dan Vickermann, et al. A full list of this casualty ward would represent a handy Super Rugby team.
Watching their makeshift team hold their own later, however, demonstrated why the Waratahs have been Australia's most consistent team for most of the last decade – they play on the potent combination of guts and pride.
Brock's service was a wonderful celebration of a life both well and fully led. But throughout it I couldn't help thinking that the one person who would have most loved to have been there was Brock himself. That is the irony about funerals; it's a celebration without a host (and that's no pun on Anglican services).
Just one day later, in another corner of Sydney, my biographer and former Wallaby Peter FitzSimons rolled out a bash for his 50th. In some ways a 50th is like a funeral, only you personally send the invitations and enjoy it as much as anyone else.
And at least you actually get to listen to your friends and family eulogising publicly about both how much and why they love you. Now I am definitely not suggesting that life ends at 50 – far from it – but 50ths could be the perfect time to have a "funeral" for the living.
It's probably about the right age. By then you have had plenty of opportunity to mark your card, so guests should be able to find something worthwhile to say about you.
And by then you would also have worked out who your real friends are and who are the pests in your life, and you should be beyond worrying about the consequences of not inviting any of the latter.
Along with funerals, retirements are another opportunity for eulogies of sorts, a time when even those who agitated for your departure, both privately and publicly, now only speak well of you. Phil Waugh will understand that better than most as he has just signed off after a more than decade of playing for the Waratahs.
The ultimate compliment for Waugh could be that, by the end, the Waratahs became the very embodiment of their captain's attitude and his resilience.
In fact, just like Morgan Freeman actually looks more like Nelson Mandela than Mandela does these days, the Waratahs resembled Waugh more than Waugh did.
For, as his personal resilience and imperviousness to injury declined, the Tahs' courage and uncompromising pursuit of substance – not without style but not necessarily with it, either – advanced.
They were both at times misunderstood (finishing the competition as the leading try-scorers indicates the Waratahs probably played better than fans and media interpreted).
But, unlike their skipper, the Waratahs were undone by inconsistency. With Waugh there was little fluctuation in his form. You knew exactly what to expect, whereas the Waratahs destroyed some teams and yet were dismantled by others, not defensively but more through the destabilisation of their offensive structures.
All teams win and lose, but to seriously threaten a competition you must consistently beat the top teams. This season the Reds have beaten every team in the top six save the Sharks, who they didn't play (the Sharks were eliminated at the weekend after losing 36-8 to the Canterbury Crusaders). From a Waratah standpoint, their record against the top teams was not as impressive. They only beat the Reds and that was back in February.
Similarly, Waugh never quite rose to consistently be considered the number one flanker in the country as first George Smith and now David Pocock have held that mantle.
But despite everything, Waugh was a man you wanted on your team. If he were an investment he would be capital-guaranteed. His epitaph will record him as uncompromising, both of his own standards and of those around him.
He was a dominant figure in a dominant team, albeit one, from his own admission, that never quite achieved what it set out to do.
Even at the last, when offered egress after his injury-ravaged team was eliminated by the Blues, he didn't accept it, instead claiming a successful season was one where you won the competition. You have to respect that.
His teams were invariably better and more confident when he was on the field – he led them well.
For 2011, though they would be disappointed, both Waugh and the Waratahs can simultaneously bow out with their heads held high.
So with the departure of the Waratahs, only the Reds remain of the Australian teams and I certainly hope that, after this week's semi-final against the Blues, we won't also be eulogising their season. I'd much prefer to do that in two weeks after they win the final.
The Australian Financial Review


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Let me introduce myself. My name is Mark Sisson. I'm 63 years young. I live and work in Malibu, California. In a past life I was a professional marathoner and triathlete. Now my life goal is to help 100 million people get healthy. I started this blog in 2006 to empower people to take full responsibility for their own health and enjoyment of life by investigating, discussing, and critically rethinking everything we've assumed to be true about health and wellness...Tell Me More
Everyone agrees that being sedentary is bad and unhealthy and that being active is good and healthy. The research agrees, too; regular physical activity leads to good health, longer lives, and an improved ability to function throughout normal life. When you're able to walk to the store, carry your groceries home, take the stairs, get out of bed without struggling, pack enough lean mass to survive a stay in the hospital, and ride your bike when you want to, you're a functional human being, and remaining active on a regular basis helps maintain this state so crucial to basic health and happiness.
But what's often hidden amidst the blanket pro-exercise sentiment is that too much exercise can have the opposite effect on health – people can really take physical activity too far. I talk about this all the time, so much that you've probably got "Chronic Cardio" emblazoned across your brain and shake your head when you see some hapless soul in spandex and the latest runners heaving himself down the street, heel first. I know just how bad that stuff can be, because I did it for a large part of my life. You've all heard that story before, though, about how even though training cardio hard gets you "fitter" in one sense of the word, it's actually counterproductive for a healthy long life (doubly so if you want to have some lean muscle mass and pain-free joints in your later years).
We've seen hints in studies over the years:
One recent study found that in overweight sedentary subjects, moderate exercise was more efficient at helping them burn body fat – including a reduction that was far greater than what could be explained by the caloric expenditure – while intense exercise induced a "compensatory" response that hampered fat loss.
Another study examined weekly caloric expenditure via aerobic exercise in a group of former athletes and non-athletes and plotted it against mortality, cardiovascular disease, and hypertension. Death rate was highest in groups 1 and 2, the ones with the least amount of caloric expenditure, but group 6 (along with 1), which expended 2,500+ calories per week, had the highest rates of heart disease and high blood pressure. Those who exercised moderately lived the longest and were healthiest.
In a study on the exercise habits of college alumni and their impact on mortality, researchers found that up to 3,500 calories expended per week conferred a survival benefit, but at calorie expenditures greater than that, mortality began to tick upwards.
And in a pair of recent studies, researchers found that moderate exercise – jogging up to 20 miles a week at an 11 minute mile pace – offered the most protection against early mortality. Running more than 20 miles a week, or running at a 7 minute mile pace, offered fewer mortality benefits. In the second paper, Danish scientists found that people who spent one to two and a half hours jogging at a "slow or average pace" lived longer than those who didn't run at all or who ran at a faster pace. James O'Keefe, a cardiologist and presenter at the Ancestral Health Symposium, was quoted as saying that "after about 45 to 60 minutes a day, you reach a point of diminishing returns."
It's pretty clear that once exercise gets to be "too much," the benefits are reduced, or even reversed, and it becomes a chronic stressor that reduces overall wellness.
And so I thought it'd be helpful to give you guys a guideline for determining just how much is too much. This is a guideline I've had great success with, whether I'm training myself or clients: no more than 4,000 calories expended through focused exercise per week.
Is this a hard and fast rule? No, not exactly. Going somewhat above is probably okay.
Is it concretely established in numerous studies? There are hints toward its veracity in the literature, but nothing explicit. This is mostly stuff gleaned through experience (but the research does bear it out).
Does it apply to everyone, everywhere, whatever their goals may be? No. Someone training for the Hawaii Ironman Triathlon is going to require more if they hope to compete.
But as a general rule for the general population, it really does work well as a guideline. Burning 4,000 calories through focused exercise appears to be the cut off point (yeah, you could go a bit under or over, but the point is that we need to draw the line somewhere) after which health – including immune function and oxidative stress load – and quality of life – including free time, energy levels, and productivity – begin to take hits. Your performance may increase, and this might be worth it to you if your goals are primarily performance-oriented, but there's a trade off. Keith Norris often writes about this idea, calling it the health-performance curve. I'm inclined to agree with him.
So – what does 4,000 calories worth of expenditure in a week look like, exactly?
Well, the simplest way I've found to describe it is in terms of road miles. If you're doing 40 miles a week running or 80 miles a week cycling, you're hitting roughly 4,000 calories. We don't just run or bike, of course. We lift weights, we circuit train, we engage in metabolic conditioning, we row, we wrestle, we hike, we sprint, we box, we swim.
You could use an online calculator like FitDay or ExRx to get a better idea. For a 185 pound, 6 foot tall person to burn just around 4,000 calories a week, he could get away with:
That's a pretty solid week of activity, I'd say, but it certainly isn't excessive, and it would provide a far more well-rounded sense of fitness than just pounding away at the road for 40 miles. Feel free to use the (admittedly imperfect) tools linked above to figure out what your regular caloric expenditure looks like.
Not all activity "counts" toward your caloric expenditure. Taking a 30-minute stroll to the store doesn't count as focused work. Taking a 60-minute hike up in the hills does. Going for a nice relaxing ride on the bike around the neighborhood doesn't count, but doing twenty miles in a single day does. Carrying the groceries from the car to the house doesn't count; carrying the groceries from the store to the house just might, though. "You know it when you see it" applies here, so use your better judgment.
I'd also suggest that expending your calories through a variety of activities is "better" than expending them through a single activity. As shown above, lifting weights, going for a run, biking a bit, and playing sports is more fun and probably less stressful than expending all your calories through running, which is veering into Chronic Cardio territory. A calorie (expended) is not a calorie (expended).
Look – exercise as often and as intensely as it pleases you. Just be aware that, in my opinion (having looked at the literature and drawn from my own experience training myself and others), 4,000 calories of focused work per week is the cut off point after which health and happiness begin to suffer for most people. If you're an athlete whose only job is to train, and you're privy to massages and cutting edge recovery techniques and everything else, then you'll be able to handle more work. You'll be far fitter than the average person and thus better equipped to mitigate the oxidative fallout from excessive exercise. But for members of the general population who have to contend with the day-to-day stress of living in this world, getting up early to feed the kids and beat traffic, balancing exercise time with work time with family time with personal time, sneaking peeks at the latest blog post, hoping to get enough sleep to make it through the next day? You're going to have a harder time recovering from the stress of a 4,000+ caloric expenditure to make it worth your while.
That's it for today, folks. Let me hear what you have to say about this 4,000 calories a week guideline. Do you agree? Disagree? Wholeheartedly forsake everything that I henceforth write? Let me hear all about it!
If you'd like to add an avatar to all of your comments click here!
192 Comments on "Why You Shouldn't Burn More Than 4,000 Calories a Week Through Exercise"
I know the action of (tabata) sprinting doesn't in and of itself burn many calories, but you're supposed to continue burning through calories at a quicker pace than normal all the way through recovery.
Mark/anyone else, any insight on how sprinting should be accounted for in here? (eg. 8 sprints of 20 seconds followed by 10 second rests)
Hard to say. I think the calories expended during afterburn from things like Tabada protocol or interval workouts should fall in the "recovery" bucket instead of the "exercise" bucket.
The duration of a sprint workout should be regarded much the same as the duration of a weight training workout, high intensity with periods of rest, so the half hour spent on sprint workout is like half hour of intense training in the gym. Provided you really put effort into the sprints and don't rest too long.
Just remember Aristotle–moderation in all things. He was ahead of his time! (By a few thousand years). Yet we still see the wisdom.
Moderation in all things…….including moderation!!
Re: "Moderation in all things…….including moderation!!"
Please, no "clever" sophistry.
I don't really like that saying because it's so easily misused.
Hey, how about a moderate amount of Doritos every day? Or could somebody smoke in moderation? How much is a moderate amount of cocaine?
Hmm, I don't think so.
I think you're looking at it backwards. ie. not to say "do a little of everything," rather, "moderate the things you DO."
If you're going to smoke, better be it in moderation than excess!
I agree , people often use that saying as an excuse for poor health choices or as a way to diminish people who are trying to be mindful of their health.
You seem to be forgetting that "moderate" amounts include ZERO amounts.
In this case, to moderate, is to govern things within acceptable levels. For some things, that number is zero.
Like DavidD said, it's pure wisdom.
It's easy to take Aristotle out of context because moderation was not a virtue itself; it is a mode of his virtues like temperance and courage. In this case you would be talking about temperance.
Each virtue becomes a vice if it is exhibited in excess or deficiency.
Chewing coca leaves could well be considered a moderate amount of cocaine.
the more i do the better i feel, the better my results, and the better my attitude is towards others and the outlook on my own life. i believe if u can do it do it.a fish is only as big as its environment. have to expand to grow
I don't think the EPOC of Tabatas is nearly as high as you think. Yes, you will burn a few extra calories for a while when you are done, but it's not like you are going to burn 4,000 more
The extra 2/3 of a 1/2 calorie burned through intervals are negligable compared to steady state aerobics. Any new fad has to be the opposite of the mainstream fad to gain a foothold. Three meals became six. Six meals became "intermittent fasting". High volume, no! Low volume! Low fat, blah blah blah… low carb, blah organic blah paleo blah blah gluten free blah BLAH BLAH… each "expert" chiming in, or more accurately, cashing in. Hilarious. Alan Aragon must be pissing himself in amusement. Get out the popcorn… oh wait…
This makes my daily 16-mile round trip commuting through London bad for me then?
I disagree that daily leisurely walks don't count. Whether its up a hill on a trail or up & down the paved streets, I sleep better & feel better when I walk daily. But I do other stuff too 4-5 days a week & "try" to take 2-3 days a week time off too to rest & restore my body. Sometimes I only get in 1-2 days of rest coz I'm busy/productive
It seems that more and more fitness buffs are turning up their noses at walking–erroneously so, IMO. Walking is excellent exercise, particularly if done in hilly areas. It gently moves almost every muscle in the body without much risk of injury. It's also pleasant, relaxing, and promotes better health. On it's own it might not make you an Olympics-caliber athlete, but it's so much better than being a couch potato.
No, Mark's not saying easy walking isn't good for you; quit the oppositie. It's a key part of the Primal Fitness Blueprint approach. He's saying don't worry about it counting towards "chronic cardio".
Speaking from plenty of personal experience, the farmer's carry accomplishes wonders. I suspect especially so when you adjust the position of your arm to keep it feeling proper. The benefits include increased muscle tone and development and better arm mobility.
Wow. That's impressive. Hope the air quality's okay.
Depends on if it's swimming up the Thames, biking, or running headlong through the streets…
"Avoid trauma"…. Bloody hell, that's a daily occurrence on that journey.
🙂 🙂
If you're doing it every (work) day, your body will come to a homeostasis with it, eventually. As long as you're not getting to work panting from exertion, it's not hurting you, I shouldn't think. If it doesn't feel like work, count it like a walk. It's great, but it's not really work.
Yes, if nothing else because it's in London! (hardly fresh, unpolluted air…)
Don't fret, I doubt you're bursting into full sprints around town and you likely have to pause a great deal in the city. Mark is just saying that high mileage running, biking and swimming may not be healthy. It's stressful. 16 miles of hard pushing it biking would be worse.
Great post Mark. I know that in the past I could tell when I had exceeded healthy amounts of exercise just by how my body reacted. For example, I used to play intense sports for several hours several hours a day, and I would inevitably reach a point where one day I just wouldn't fully recover and knew a few days of rest were needed.
It's amazing how much we can learn just from listening to our bodies, but this post is great for a more concrete outline.
Same here, when I've been healthy I've always gone at it like a rabid wolverine, I figure I average 800 calories a day.
Only problem I have is over time it does tend to mess with my immune system, but other than that it's the best part of my life, it's the absolute last thing that I would cut back on.
I'm curious how old you are. i used to feel that way about training in my 20's but now that I am in my 50s less is more. I am happy with a 35 mile ride biweekly.
I'm 28. So maybe that's why!
I am 50, I can't push myself as mercilessly as I did when I was in my 20's and 30's but I can get in a morning run and weights in the afternoon.
I find I need to take a few days off every three months or so.
Do you think this could be a result of the stress relief associated with exercise? I have had quite a few clients who say exercise is a great stress reliever and they feel great but when it comes down to strength and energy system conditioning progress, they have stalled out.
I notice that in all of the positives you list, longevity is not included. Sure you feel better today, but once you've burned up all of your youth, what will you have left to rely on?
It's really just a matter of time preference and economics. Your perspectives all seem "now" oriented, so you've little reason to consider the benefits of economizing exercise to retain their benefits over a longer period of time.
Of course, this is merely my opinion based upon two brief posts of yours, so please don't take offense.
Let's talk again when you hit 50…
Talk again when you're 60 like me. I think I'll use this 4000 as a guideline, even if I have to convert it metric and SI…
Remember as well, the life differences we're talking about here may not be more than 5-8 years. If you bike all the time and love it and it takes you from 90 to 85 years life end, does it really matter in the long run?
I think you mean "does it really matter in the long bike?", right? I'm just assuming.
Don't forget about quality of life. If you die sooner from ill health, it will start affecting you long before it kills you. That 5-8 years of less living might equate to 20-30 MORE years of needless suffering.
"There's no such thing as overexercise, just undereating and undersleeping."
If 4,000 weekly exercise calories is the maximum recommended, what would be the minimum weekly exercise calories?
that was the 1st Question in my head when I read this article! 4000 cals a week? no way! minimum effort for maximum results, that's my motto. lol
My guess is that the PB workout schedule Mark describes in his book is the bare minimum for good results, whatever calorie expenditure that gets you to. that is my working assumption. Tim Ferris also has some interesting ideas on the subject of less is more.
Funny you should mention Ferriss. I just finished the 4 Hour Workweek, and his suggested application of the 80/20 principle alone made it worth the read.
In terms of exercise, I've decreased the volume of workouts while fine tuning some lifestyle/dietary habits, and wow, my schedule is suddenly open and I no longer find myself lugging around the psychic baggage of anticipating a difficult workout all day long.
Every day, I see this heavy guy slapping his feet down on the road, with this slow, rhythmic sound. Round and round the block he goes. One day, I'm going out there, push him in the chest to stop and shout 'Dude, you're doing it all wrong!"
Have you considered that he might enjoy this activity?
I assure you he doesn't. He does it cus he thinks it will burn the fat away.
And you know this how?
It is impossible for a human to enjoy physical activity for its own sake?
Nothing inherently rewarding from it?
Boy people here sure know a lot of stuff.
Hey may enjoy it, but his joints won't.
If he feels good about himself about doing it, who are you to judge? He's out there trying hard to make himself a healthier person–at least he's not sitting on his keester in front of a television. Cut the guy some slack, you have to start somewhere.
For all we know that morning jog is the best part of his life, the thing he looks forward to every single day and makes everything else worthwhile.
He runs around the block, I run along the waterfront, not everyone has a scenic vista available to him.
If he enjoyed it, he'd be better at it (no slapping feet).
I see that all the time, people running out of a sense of obligation. They look uncomfortable at any pace. Then there are others who make it look a lot more effortless and probably do enjoy it.
Thank you for telling the people of the world how they should run, really coming from you it means a great deal.
you should ask him how the running is going for him and then suggest he visits marksdailyapple 😛
Yes because it is impossible for him to enjoy physical activity for its own sake, impossible for a human to take joy in physical activity.
Alison – take a plate full of bacon out for the poor guy!
Alison you can push my chest… but I make sure to arch my feet and have some running form … actually as a heavy guy I swim and lift and spin alot more than run… when I am lighter I will get back to running… right now walking hills at a good pace sounds good…. already calculated my 4k Cals in my daily routines .. thanks Mark for the guidelines … I like them and good reasoning for the limitations… quality material … thanks !
Very informative and helpful, thanks! I'll be sharing with my running/workout friends. (Already did once!)
Mark, you should offer a class or figure out a way to get a "Primal Fitness" Certification program started. I follow your work to the letter of the law, and all of your blog posts are incredibly informative. I'd be one of the first people to sign up to be a Primal Fitness/Lifestyle Certified Instructor. Great post!
I partially emulate Mark's plan. If you want similar results as someone it's probably wise to model some of their behavior.
I usually start the day with as much coffee as I feel like (sometimes none) and occasionally sweeten it. I prefer to use blackstrap molasses. That way I get a dose of minerals including potassium with the coffee and sugar. I think it helps maintain a good electrolyte balance.
When I sweeten coffee I usually use cinnamon to reduce blood sugar spikes and get more antioxidants.
If you want to tip-toe through life and play it safe, never reaching for greatness, and are more comfortable with the rewards of low risk, then this is the plan for you.
Not everybody has maximum athletic "greatness" as a primary goal. There's no reason to be so smug about it.
Joy, beautifully said. +1
Mark stressed repeatedly that this is an approach for the average Grok/Grokette.
Jeremy's comment sounded smug to me as well but it reads logically.
Well, except for the "greatness" part (a wholly subjective standard of measure).
Myself, I'll feel pretty great outliving all of the smug athletes who would trade their most precious commodity (time) for a bit of athletic glory.
I think people are greatly overestimating the decrease in life expectancy, especially as applied to any specific person. If I run 50 miles a week, will I really die 5-10 years earlier?
I don't think so, but you can believe that if it makes you feel superior to me for enjoying some longer runs.
Any hints for adjusting this – I weigh about 2/3 what your theoretical 185lb. fella does… Should I be thinking in terms of 2/3 the time, the 'calories', the road miles….? Will it basically adjust automatically because it 'costs' me fewer calories to haul myself around?
Oy, I'm talking about calories.
Also – when you say stuff like walking around doesn't count – you mean it doesn't count for purposes of this cutoff, right? It still 'counts' toward making us generally happier, perkier, etc…. right?
This is what I would like to know too. For me (36yrs, 120lbs, female), I would need to do 11 hours of intense weightlifting to burn around 4000kcals.
If it's 4000 for 185lb, that's about 2600 for 120lb… not allowing for gender or age.
Did those studies control for food in? I would imagine the average person at super high levels of activity is eating more and likely eating more higher carb foods, including all of those nasty in-activity gels, blocks and other forms of corn syrup.
I'm curious if a sample exercising at 4,000+ calories/week but making it up with high quality fat and protein would see the same ill effects.
I am also curious about this. In the summer, I bike a lot but I don't eat a ton of carb-y foods.
I understand that for the example given above, 4,000 calories isn't a lie of activity, but for a 120 pound woman, burning that much takes more work. Does that mean women need more activity, or does it mean that we should be more on the "lower or under" side of 4,000?
I was wondering the same thing. I'm 5'4 and under 110, and it would take considerably more effort for me to burn that much vs a somewhat overweight man. Is the 4000 calories scaled down in my case or is it static?
i'm wondering the same thing.
cause i have no idea what 4000 is for a woman. 161 cm, 47.5 kg -> 5'3″, 105 lb.
fitday says brisk walk or slow run 250 – 350 cal/hr.
if we use the avg. (300 cal/hr) for moderate exercise,
=> 13.3 hr/week, yes?
I'm with you farmgal!
I have a small farm, in my fifties, and walk everywhere, using a wheel barrow instead of a ute and mustering stock on foot instead of a motor bike. I hate formal exercising, hate jogging, but love to look for functional exercise, the above, digging in the garden, working around the farm. Horses for courses, reading this article made me feel a bit glum, as 4,000 calories on all that stuff a week is just a pipe dream for me!
It's still not 4000 or anywhere near though. I calculated that I would need to do 11 hours of intense weightlifting to burn 4000 calories.
Interesting. Since I mostly run, I'll need to see what 4K calories looks like.
Sprinting makes the difference between ogres and trolls.
Undeniably believe that which you steatd. Your favorite reason appeared to be at the internet the simplest thing to remember of. I say to you, I definitely get annoyed while folks consider concerns that they plainly do not understand about. You controlled to hit the nail upon the top and defined out the entire thing without having side-effects , other folks could take a signal. Will likely be again to get more. Thanks!
Sprint training is my preferred 'running' modality. It embraces both the moderation and hard-work principles.
I'm not a runner but the sprint intervals I do helped me a) lose fat and b) gain and maintain muscle all through my bod the past 5 years.
I recommend it especially for those of us that hate the thought of running for hours and miles on end. Marathons aren't for everyone or for everyone's personality.
And sprinting has saved my knees…just be sure to warm up. Quad and ham tears if you're stupid!!
Isnt a leisurely ride round the neighbourhood and a stroll to the store moving frequently at a slow pace? No mention again of "natural" exercise, working in the garden, chopping wood etc as well as taking the stairs instead of the lift etc and just trying to incorporate more natural movement and exertion into your daily life.
Sounds sensible. Of course, at the moment I'm quite sedentary due to a foot injury. Oh well, c'est la vie!
I see the validity of this argument. You're certainly not encouraging a couch potato mentality – just explaining that trying to train like a full time athlete while balancing other responsibilities can just cause unecessary wear and tear. If the body likes moderate amounts of just about everything else, why would immoderation suddenly apply to exercise?
While the wife trains for her 2nd Ironman,I will train for my 2nd Ironman spectator race.
My goal of sprints to the hotel to grab another handful of primal trail mix and an apple are progressing at an amazingly moderate pace.
This made me giggle. I hope you both kick butt, respectively 🙂
Haha, yeah, being kinda small anyway, I don't think I would burn 4000 calories of exercise a week, just because I wouldn't care enough to do all that!
I'm wondering how much of the increased mortality with quantity (i.e. calories) and intensity (like running pace) is due to the acute stress associated with mouth breathing? I've been experimenting with 100% nasal breathing, and have managed to exceed my PR on a local hill climb after an initial performance decline. The PR happened with lower heart rate, and lower breath rate (deeper breathing). I also recover way faster when 100% nasal.
Any thoughts on this, or nasal breathing in general?
I think this is one of those things where if running too many miles is your biggest health problem, you're probably doing pretty well…
Mark, I love you; and I do get the general idea and it's good, but:
I do not have a good idea what 4000 kcals of exercise "looks like" from this. I don't count calories of food, and I can't count calories of exercise. At least give us another example, such as for an average woman. That would be helpful.
…Pleasant Good Day!…I would say that promedades do have some real benefits like: physic and physio. I do agree with you on the '4,000cal limit. Blessings!!!
Being the wife of a 50 year old cyclist that rides easly 40+ miles on a daily basis,and used to run 10 miles on a daily basis, I've always thought that his immune system gets compromised easily. He catches colds much easier than I do, and since he races/raced in both sports, he's put it a lot of miles to be competitive. This helps my case!
I don't think you needed this article to back up your theory. I'm sure all you have to do is look at him with his shirt off and know he's in bad shape. My guess is you have more lean mass than him. Muscles aren't a bad thing and mr bones needs to start realizing that.
I have struggled all my life with my weight and i am at my wit's end. I JUST did the math on my caloric burn per week last saturday and I just dont know what to do anymore. I am capable of burning 14cal/min for 50-60min. 11 cal/min if you include cool downtime, stretch time and shower time. Usually that takes another 40 minutes. If I total up the week, it usually adds up to about 6000 cal week. What am I doing wrong? I dont eat THAT excessively. I need advice.
Have you read any of the research done by Dr. Robert Lustig? Check out this video series (this is the link for the first of 7 short episodes).
In terms of exercise, I believe that less is more. But being consistent with the "less" is the key. Go easy on our joint systems and focus on continually correcting/improving our bio-mechanics of movement as opposed to focusing on time or distance.
As a result of this approach my skills are constantly improving as is my speed; though I'm not even trying to go faster. It's been a very interesting experiment.
What is your feeling about interval training, such as one minute intense, one minute relaxed, and so forth, for 20 minutes? I have read that this kind of workout a few times a week is extremely beneficial as opposed to "chronic cardiac."
Doing High Intensity Interval Training about once per week is what Mark recommends, mixed with low intensity walks, biking, etc. It does work.
This is yet another study showing that we (Humans) were not built for constant stressful, strenuous activity. I am with Mark 100%. Even just a few years ago when these concepts were not in vogue, I decided to start weight training twice a week, instead of the usually recommended 3-6 days. I got better results as I was more recovered. And, I had a lot more time out of the gym. I was very happy to see Mark, and a few others preach this less is more concept.
I am 63 yrs old and have practiced Mark's exercise and nutritional plan for about 8 months. I have trained most of my life. Now, my workouts are shorter, but more productive. I have added muscle, reduced fat, lost inches from my waist and gained on my chest and arms. Do not let anyone suggest that age is a limiting factor in the results achievable using this program!
I'm not sure I've ever really come close to that number as a short female, even when training for a half marathon. My max mileage per week was probably 20 miles, so 2000 calories or so.
Now with an infant and a six year old, I do even less. Three days of strengthening (15-20 mins per day). Two days of intervals (15-20 min). One day of a spin class (40 min), and one day either walking or swimming.
Does this 4000 calories apply for athletic children and growing teenagers?
Mark, I know what you mean about overtraining. I used to burn well more than 4000/week. I would train 15 hours a day, 7 days a week for years. And all that did for me was land me in the hospital repeatedly. It takes me a while to learn. lol
15 hours a day of training?
That left you 9 hours for everything else, how did you manage it? Even if you only slept 4 hours per day, that leaves you with 5 hours for everything else.
The reason it's counterproductive to burning fat because your body starts release cortisol. So if you are doing too much, your body stops burning fat. From a composiiton standpoint, you're getting fatter and losing muscle.
I think it makes sense, but how do you figure it for people significantly above the norm. I'm overweight now but when I've been in great shape I'm pushing 240 lbs (at 6'3)
My guess is 5000 would be a better guide for me doing the exact same activities Mark lists at the end of the article.
Very sound advice – i believe way to many of us over train especially those not in "sport specific training – While not enough emphasis goes into proper eating lifestyle. I would also make the correlation that if loosing 2 lbs a week seems reasonable you could extrapolate that of that choloric adjustment appropriating about 50% to activity/exercise and 50% to caloric reduction that you would theoretically would come to the support of this 4K expenditure conclusion
I believe dancing should be included in any healthy activity. It is a time-honored remedy for ailments. (think traditional healers) Plus, if you are doing it with joy, it's a whole lotta fun! It is my firm belief that any of these activities if done with joy have value added! Thanks Mark for bringing another thoughtful topic. Now let's dance!!
I just left a 70-hour-work-week-job, to find more balance in my life… including to re-introduce a regular exercise program back in! (I've stayed on-board with a more primal way of eating, Thank God!) In light of this, I truly find it a comfort — and a relief! – to be reminded here that the opposite extreme (too Much hard exercise) is neither helpful nor productive for the 53 year old non-athlete that I've become! This is a Great time for me to hear Mark's words on Exercise Moderation for the general public. Thanks, Mark!
I started the Primal workout back in early July and promptly snapped my Achilles tendon in the 2nd series of sprints. I used to fall into the Chronic Cardio zone, running 30+ miles a week, so I probably overdid it transitioning back to sprints (I was a 400M sprinter 34 years ago). I've had 2 Orthopedists tell me that sprints should be out due to a bad lower back and now the Achilles repair, so I guess I'll be looking for alternatives to burn my 4K calories a week.
This is so funny because I can tell the age by the commentary. The under 40's are fighting to defend their chronic cardio as I would in my 20's & 30's back when I would do 2-a-days and was never sore or injured. Invincible, believing it would never end!
Then the 40's arrive… Sometimes, I lie awake wondering if my hamstrings will ever completely heal, or if I just pushed too hard for too many years…
Hmm…so you completely changed two aspects of your life (diet and exercise), had a good cold year, and assume that it was the reduced exercise that did it? Ok…


text:
Sunday 15 November 1931
It was Sunday, under the sign of Scorpio. The US president was Herbert Hoover (Republican).
Famous people born on this day include Jan Terlouw and Pierre-Désiré Allaire.
Possessed, directed by Joan Crawford, was one of the most viewed movies released in 1931
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- Austria - Saint Leopold's day -- no school in Vienna, Lower Austria and Upper Austria
- USA - America Recycles Day
- Norway - The official skolebr�d-day on Sunnland skole
- Roman festivals - Festival in honor of Feronia (others say 13 November)
- Brazil - Republic Proclamation Day (1889)
- R.C. Saints - Albert the Great
- Palestine - Independence Day (declared 1988)
- Eastern Orthodoxy - Feast of Saint Philip the Apostle and the beginning of Winter Lent; also see November 15 (Eastern Orthodox liturgics)
Famous Birthdays:
- Jan Terlouw: Dutch MP (D-66) / author (Winters in Wartime).
- Pierre-Désiré Allaire: French horse trainer and jockey who won the 1978 Prix d'Amérique on Grandpré.
- John Kerr: NYC, New York -- Actor (South Pacific, Peyton Place, Pit & Pendulum).
- Mwai Kibaki: Kenyan economist and politician 3rd President of Kenya.
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- Cornelis A J van Dishoeck: Publisher.
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text: Voters give green light to school funding campaigns By Miller Hudson on November 12, 2012 Elections proved that City Hall and school boards came out on top with voters in Denver, JeffCo There was no greater evidence on election night that politics remains a soft science than the green light Colorado voters gave to most of the school funding campaigns waged along the Front Range. It proved a surprisingly good […]This content is only available to subscribers. Login or Subscribe Share this:EmailTwitterFacebook Current News, Miller Hudson, The Colorado Statesman, Title Item


text:
The president-in-waiting of China has gone missing for more than a week, prompting wild speculation ranging from ill health to an assassination attempt barely a month ahead of his expected rise to the top job.
The Chinese government has refused to acknowledge the mysterious absence from the political stage of Xi Jinping.
Most credence is being given to suggestions Mr Xi suffered a serious, but not life-threatening stroke, and is not well enough to appear in public.
The health of China's top leaders is considered a state secret, although such rumours would usually trigger a hastily arranged public appearance.
"I have heard [Mr] Xi's condition is improving but he is not well enough to be put in front of a camera," said Willy Lam, an expert on elite Chinese politics at the Chinese University of Hong Kong.
Australian-based China experts were mystified by the disappearance and leaned towards the theory Mr Xi had suffered a minor injury.
Mr Xi's absence comes months after top party official Bo Xilai was sacked for his role in the death of British businessman Neil Heywood. Mr Bo's wife, Gu Kailai, was later found guilty of murdering the Briton and sentenced to life in prison.
The scandal upset the delicate political balance in Beijing, resulting in an outbreak of factional warfare, as Mr Bo was tipped to win a place on the Standing Committee, the country's top decision making body.
Those political issues appear to have been settled in recent weeks, but Mr Xi's absence from public life could see them flare again.
Mr Xi's last public engagement was on September 1, when he attended the opening ceremony of the Central Party School in Beijing. Since then, he has cancelled meetings with US Secretary of State
Mr Xi also failed to attend a Communist Party meeting on Friday.
A report on a Hong Kong gossip website said Mr Xi had been the subject of an attack, possibly by supporters of Mr Bo.
The former Politburo member is waiting to see if he will be charged and go before a court or be dealt with by the party's internal disciplinary body.
The Boxun site suggested Mr Xi was rammed by two off-road Jeeps and passed out during the collision.
The Communist Party is still refusing to announce the date of its forthcoming Congress, at which Mr Xi is expected to be unveiled as the country's new President.
The last Congress, in 2007, was in mid-October, but Mr Xi's apparent illness may complicate the timing.
"I don't think they can replace [Mr] Xi, it's just too late and would be too disruptive,' Mr Lam said.
Mr Xi visited Australia in June 2010 to meet with then Prime Minister
Defence Minister
Mr Xi did not attend the APEC summit in Vladivostok last week.
Foreign Minister Bob Carr did not hold talks with Mr Xi on a visit to China in May when he met with Foreign Minister Yang Jiechi
Mr Lam said Mr Xi is likely to assume office with a serious question mark over his health and ability to run the world's largest country and second biggest economy.
Mr Lam said he had been in contact with Communist Party cadres in Beijing who said Mr Xi was suffering from a serious but not life-threatening health problem.
"There are rumours of a stroke," he said.
Suggestions of an assassination attempt were "totally off the mark".
"But the [Communist] Party is responsible for these rumours," he said. "People have a right to know the health of their politicians but in China's case it remains a state secret and that is why there are all these rumours."
A spokesman for China's foreign ministry, Hong Lei, failed to answer questions about Mr Xi's whereabouts at a regular media briefing on Monday.
The Australian Financial Review