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This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
Here, we report a natural chemical Matrine, which exhibits anti-melanoma potential with its PTEN activation mechanism. Matrine effectively inhibited proliferation of several carcinoma cell lines, including melanoma V600EBRAF harboring M21 cells. Flow cytometry analysis showed Matrine induced G0/G1 cell cycle arrest in M21 cells dose-dependently. Apoptosis in M21 cells induced by Matrine was identified by Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) analysis and Annexin-V/FITC staining. Molecular mechanistic study suggested that Matrine upregulated both mRNA level and protein expression level of phosphatase and tensin homolog deleted on chromosome ten (PTEN), leading to inhibition of the PI3K/Akt pathway. Downregulation of phosphor-Aktser473 by Matrine activated p21 and Bax, which contributed to G0/G1 cell cycle and apoptosis. Besides, Matrine enhanced the PI3K/Akt inhibition effects to inhibit the cell proliferation with PI3K inhibitor, LY2940002. In summary, our findings suggest Matrine is a promising antitumor drug candidate with its possible PTEN activation mechanisms for treating cancer diseases, such as melanomas.
The tumor suppressor gene phosphatase and tensin homolog deleted on chromosome ten (PTEN) is a 47 kDa protein, which was first identified as a candidate tumor suppressor gene in 1997 [
PTEN is often downregulated in many poorly differentiated cancers, including breast cancer, colon cancer and melanomas [
Matrine (C15H24N2O,
In this study, we evaluated the antitumor potential of Matrine in a V600EBRAF harboring melanoma M21 cells. We found Matrine inhibited the cell proliferation in M21 cells, but did not affect the normal human retinal pigment epithelium cells. Matrine induced cell cycle arrest at the G0/G1 phase and apoptosis in M21 cells dose-dependently. Matrine activated PTEN to inhibit the PI3K/Akt pathway and, finally, led to p21 and Bax upregulations in M21 cells. These findings suggest that activating PTEN holds promise as practicable strategies for melanoma treatment, and Matrine is a potent candidate for melanoma treatment.
As shown in
As flow cytometry results showed, Matrine induced significant G0/G1 accumulation with S and G2/M depletion in M21 cells. The proportion at the G0/G1 phase was 57.25% in the control, whereas the proportion was 69.31% in the cells after treatment with Matrine at the concentration of 0.2 mg/mL (
To investigate whether Matrine induced apoptosis in M21 cells, cells were treated with Matrine in indicated concentrations before Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay performing. By exposure with Matrine at a concentration of 0.4 mg/mL, we found a significant percentage of M21 cells stained positive after Matrine exposure (
Then we performed flow cytometry assay to identify the apoptosis. As shown in
To explore the molecular mechanisms, we examined mRNA level and protein expression of G0/G1 cell cycle regulators, p21, Cyclin D. Real-time PCR data analysis showed that the mRNA level of p21 was upregulated dose-dependently with Matrine. In contrast, the mRNA level of the positive regulator, Cyclin D, were downregulated with Matrine (
To explore whether caspases activation was involved in the induced apoptosis, we examined the activity of caspase-3 in Matrine-treated M21 cells. We found that Matrine significantly activated the activity of caspase-3 (
Besides, we examined mRNA level of Bcl-2 and Bax in Matrine-treated M21 cells. Interestingly, we found that the mRNA level of Bcl-2 was downregulated, while that of Bax was upregulated by Matrine (
As inhibition of the MAPK pathway can cause growth arrest and apoptosis in melanoma cell lines, we assessed the effects of Matrine on the expression of key components (ERK1/2) and their activation forms (phosphorylation of ERK1/2) in M21 cells. As shown in
To further explore the molecular mechanisms of Matrine, we assessed the effects on PTEN and the PI3K/Akt pathway of Matrine. Real-time PCR results suggested that Matrine did not affect the mRNA level of PI3K nor Akt, but significantly upregulated the mRNA level of PTEN dose-dependently (
Then, we investigated the protein expression of PI3K, the phosphorylation form of PI3K (p-PI3K), Akt1, Akt2 and Akt3 and the phosphorylation form of Akt and PTEN. As shown in
To confirm the effects on the PI3K/Akt pathway with Matrine, a PI3K inhibitor LY2940002 was used to examine the cell viability plus Matrine. As the results show (
We used a specific PTEN silencing siRNA assay to assess the role of PTEN playing in Matrine-induced cell growth inhibition and apoptosis. We found that the cell growth inhibition and apoptosis were sufficiently blocked in M21 cells with Matrine after PTEN silencing.
As shown in
Heterogeneity relating to cancer treatment has been observed in multiple malignant cancers, including melanoma. Both classical cytotoxics and newer targeted approaches that inhibit the pathways dysregulated by alterations in the oncogenes or tumor suppressors are identified as effective therapeutics for cancer treatment. In this study, we reported that a natural product, Matrine, effectively inhibited the proliferation in multiple carcinoma cells, including M21 melanoma cells. Matrine induced G0/G1 phase cell cycle arrest and apoptosis dose-dependently in M21 cells. That activating PTEN, which led to the PI3K/Akt pathway inhibition by Matrine, suggested that Matrine is a potent candidate for melanoma treatment.
Melanoma is one of the most common skin cancer and increasing sustainedly and rapidly worldwide. Recent progress in the analysis of genetic alterations in melanoma has identified recurrent mutations that result in the activation of critical signaling pathways promoting growth and survival of tumors cells. Alteration in the RAS-RAF-MAP (Mitogen-activated protein kinases) kinase pathway is one of the most commonly observed in melanoma. Most melanoma cell lines with BRAF mutations are dependent upon RAF-MAP signaling and are extremely sensitive to inhibition of the pathway with selective inhibitors [
Matrine is the major active component in the traditional Chinese medicine,
Recent progress in the analysis of genetic alterations in melanoma has identified recurrent mutations regulating growth and survival of tumors cells, which shed a light on melanoma treatment. Besides alterations in the RAS-RAF-MAP kinase signaling pathway, the PI3/Akt kinase signaling pathway is another commonly altered in melanoma [
As shown in
To determine the block in the PI3K/Akt pathway with Matrine, we tested the cell viability with a PI3K inhibitor, LY2940002. Expectedly, Matrine enhanced the inhibition of the PI3K/Akt pathway to inhibit cell proliferation in M21 cells, as exhibited in
As M21 is a V600EBRAF harboring cell line [
Matrine and LY2940002 were purchased from Sigma (M5319, L9908, St. Louis, MO, USA) and diluted in culture media for all experiments
Cell lines were purchased from Cell Bank of Type Culture Collection of the Chinese Academy of Sciences (Shanghai, China), including breast carcinoma cells (MCF-7 and MDB-MA-231) and human colon carcinoma cells (HCT-116). The human melanoma cell lines (M21) and A375 were purchased from John Wayne Cancer Institute (Santa Monica, CA, USA). The human retinal pigment epithelium (RPE) cells were purchased from ATCC, which were used as normal control. MCF-7, MDB-MA-231, M21 and A375 cells were cultured in Dulbecco's Modified Eagle Medium (DMEM) medium supplemented with 10% fetal calf serum. HCT-116 were cultured in RPMI1640 medium supplemented with 10% bovine serum. RPE cells were grown in DMEM:F12 (1:1) with 10% fetal calf serum. Penicillin (100 U/mL) and streptomycin (100 U/mL) were added to all kinds of medium. Cells were incubated at 37 °C in a humidified atmosphere of 95% air and 5% CO2.
3-(4,5-Dimethyl-thiazol-2-yl)-2,5-Diphenyltetrazolium Bromide (MTT, Sigma, St. Louis, MO, USA) assay was performed to assess cell proliferation after drug exposure, as described previously [
Cells were incubated with Matrine at the concentration of 0.2, 0.4 and 0.8 mg/mL for 48 h. Then harvested, treated and untreated cells were fixed with 70% ice-cold ethanol and were kept at −20 °C overnight. Fixed cells were centrifuged, washed and resuspended in PBS contained in concentration of 50 μg/mL of propidium iodide (PI, P4170, Sigma) and 100 μg/mL of DNase-free RNase at 37 °C for 30 min, as previously reported. Cell cycle was analyzed by using a cell cytometer (Becton Dickinson, Franklin Lakes, NJ, USA) and Cell Quest Pro software (Becton Dickinson, Franklin Lakes, NJ, USA).
Apoptosis assessment was performed by using an Annexin-V/FITC apoptosis detection kit (Invitrogen, Carlsbad, CA, USA), as described by the manufacturer's instructions. Briefly, cells were incubated with Matrine at the concentration of 0.2, 0.4 and 0.8 mg/mL for 48 h. Harvested cells were stained with Annexin-V/FITC and PI in binding buffer for 15 min at room temperature in the dark, as previously reported. The samples were analyzed by FACS can flow cytometry (Becton Dickinson, Franklin Lakes, NJ, USA) to determine the percentage of cells displaying Annexin-V and PI staining.
The TdT-UTP nick end-labeling (TUNEL) method was performed to label the 3′-end of fragmented DNA of the apoptotic cells with a TUNEL Apoptosis Detection Kit, according to the manufacturer's instructions. Briefly, cells were incubated with Matrine at a concentration of 0.4 mg/mL for 48 h. After treatment, cells were fixed with 4% paraformaldehyde phosphate buffer saline, rinsed with PBS, then permeabilized by 0.1% Triton X-100 for 2 min on ice, followed by TUNEL mixture for 1 h at 37 °C. The labeled TUNEL-positive cells were imaged under a fluorescence microscopy (Nikon, Tokyo, Japan) at 488 nm excitation and 530 nm emission. The cells with green fluorescence were defined as apoptotic cells.
Cells were treated with Matrine at concentration of 0.2, 0.4 and 0.8 mg/mL for 48 h. Caspase-3 activity was determined using a Caspase-3 activity kit (Beyotime), according to the manufacturer's instructions. Briefly, treated cells were lysed with lysis buffer for 15 min on ice following washing with cold PBS. After incubating, the cell lysates were incubated with 100 μM of enzyme-specific calorigenic substrates at 37 °C for 1 h. Caspase-3 activity was quantified in the samples with a Microplate Reader (Molecular Device, Sunnyvale, CA, USA) at an absorbance of 405 nm. Caspase-3 activity was expressed as the fold of enzyme activity compared to that of synchronized cells.
The cDNA temples were prepared from cells with Matrine by using a FastLane Cell cDNA Kit (Qiagen, Frankfurt, Germany), according to the manufacturer's recommendations. Real-time PCR was performed by using a QuantiTect SYBR Green PCR Kit (Qiagen, Frankfurt, Germany) with a 7500 Fast Real-Time PCR System (Applied Biosystems, Foster City, CA, USA). Primers were obtained from Shanghai Generay Biotec Co., Ltd (China). The sequences of used primers were as follows: for PTEN, ATT CCC AGT CAG AGG CGC TAT (forward) and TGT GCT GCC CTT CTG TTC AAG (reverse); for PI3K, AGG TTC ATG TGC TGG ATA CT (forward) and TGG GCT CCT TTA CTA ATC TC (reverse); for Akt, ACG ATG AAT GAG GTG TCT GT (forward) and TCT GCT ACG GTG AAG TTG TT (reverse); for p21, TCC CAA ACG CAA AGA CTG (forward) and AGG GTT TGC GTT TCT GAG (reverse); for Cyclin D, AAC TCC CTG CGA AAC ACA C (forward) and TTG AGG GAC GCT TTG TCT G (reverse). for Bax, ATG CGT CCA CCA AGA AGC TGA (forward) and AGC AAT CAT CCT CTG CAG CTC C (reverse); for Bcl-2, TTC GCA GCG ATG TCC AGT CAG CT (forward) and TGA AGA GTT CTT CCA CCA CCG T (reverse). Primers for GAPDH as the reference gene were GGT CGG AGT CAA CGG ATT TG (forward) and ATG AGC CCC AGC CTT CTC CAT (reverse).
M21 cells were treated with Matrine at a concentration of 0.2, 0.4 and 0.8 mg/mL for 48 h. Protein was abstracted, and Western blotting was performed, as previously described [
Cells were seeded in 96-well or 6-well plates before transient transfection, as described previously [
All experiments were performed in triplicate and were repeated at least three times. The results are given as mean values ± SD. Statistical significance was performed by using the one-way analysis of variance (ANOVA) test. The significance level was set as *
In conclusion, we evaluated the antitumor potential and investigated the molecular mechanisms of a natural product, Matrine, in melanoma V600EBRAF harboring M21 cells. Matrine induced cell proliferation inhibition, cell cycle arrest and apoptosis in M21 cells. Matrine regulated both the caspase and mitochondrial pathways to trigger apoptosis. Furthermore, Matrine is a promising antitumor candidate with its remarkable anti-tumor efficacy and intended PTEN activation mechanisms.
This work was supported by China Postdoctoral Science Foundation (No. 2013M531221); "Oriental Scholarship" Research Foundation, Shanghai (No. 2008-037); Research Foundation of the "Talent Development of Human Resource", Shanghai (No. 2009-022); and "Pu-dong" Development Foundation of Science and Technology, Shanghai (No. PKJ2012-Y63).
The authors declare no conflict of interest.
The structure of Matrine.
The anti-proliferative activity of Matrine in four carcinoma cell lines and one normal human cell line. Cells were incubated with Matrine as concentrations indicated for 48 h before 3-(4,5-Dimethyl-thiazol-2-yl)-2,5-Diphenyltetrazolium Bromide (MTT) was performed. All experiments were performed at least thrice and independently. Significant differences from untreated control were indicated as
|Cell lines
|Tissue origin
|IC50 ± SD (mg/mL)
|0.769 ± 0.28
|Breast carcinoma
|2.758 ± 0.19
|Breast carcinoma
|1.405 ± 0.35
|Colon carcinoma
|1.242 ± 0.17
|Human retinal pigment epithelium
IC50 is the concentration (mg/mL) that reduced cell numbers to 50% relative to vehicle-treated cells. IC50s were determined from experiments at least thrice, independently, and presented as the mean ± SD.


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In the past few years, drones have emerged from virtually been unknown to becoming a symbol of modern warfare. Almost simultaneously, artists have subverted drones by turning them into art in a rising subculture: from the drone cinema that features films shot from hexacopters, and the Drones of New York and quadrocopters fly-dancing in Austria, to David Shook's "Poetry Drone" project, which aims at raising $10,000 to buy a flying drone that will cruise over cities, raining down antiwar poems on t … [Read more...]
The Colourful Drones of Mahwish Chishty
July 1, 2013 by
Malala Yousufzai: A Story of Education, Drones, and Foreign Policy
October 30, 2012 by
On a recent grocery store run, my father and I overheard an interesting exchange between two male store attendants about Malala Yousufzai, the 14-year-old activist from Pakistan's northern Swat region who was targeted recently for her outspoken views on education. While one of the attendants bemoaned her fate, his friend, a young Pathan, speaking with the tell-tale lyricism of Urdu in a Pashto accent, proceeded to comment on how many girls like Malala are being killed by drone attacks in South … [Read more...]

subset: commoncrawl


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Choppergate: probe zeroes in on Brit national's role
The role played by British national Christian Michel in swinging the VVIP chopper deal in favour of AgustaWestland is now the focus of a multi-agency probe.delhi Updated: Feb 21, 2013 01:31 IST
The role played by British national Christian Michel in swinging the VVIP chopper deal in favour of AgustaWestland is now the focus of a multi-agency probe.
While Italian agencies managed to tap phones and record conversations of other accused middlemen — Guido Ralph Haschke and Carlo Gerosa, there is not much clarity on Michel's role.
Michel received €30 million euro (around 210 crore) of the bribe — almost €9 million (R60 crore) more than Guido Haschke.
According to Italian investigators, Christian Michel's firm, Global Trade and Commerce, was paid more than €18 million or R130 crores by AgustaWestland to buy back 10 Pawan Hans helicopters that UK had sold to India as part of an aid programme in 1980s.
Nine of the 19 helicopters acquired by India from Westland for £65 million in the mid-1980s had been shipped back to the UK in 2000, sources said.
There is also the coincidence of Beetle Nut Home, a subsidiary of Michel's Dubai-based firm, inducting two Indian origins British nationals a week after the defence m inistry signed the contract for the choppers.
CBI seeks documents
Senior officials of CBI met in Milan the Italian judge and public prosecutors who are part of a probe into bribery charges against the firm that had bagged the contract. CBI, which is conducting a probe into the deal made in 2010, said it had requested for a certified copy of the probe-related documents.


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Bristol, UK (SPX) Dec 07, 2009
In the long term, the Earth's temperature may be 30-50% more sensitive to atmospheric carbon dioxide than has previously been estimated, reports a new study published in Nature Geoscience this week.
The results show that components of the Earth's climate system that vary over long timescales - such as land-ice and vegetation - have an important effect on this temperature sensitivity, but these factors are often neglected in current climate models.
Dan Lunt, from the University of Bristol, and colleagues compared results from a global climate model to temperature reconstructions of the Earth's environment three million years ago when global temperatures and carbon dioxide concentrations were relatively high. The temperature reconstructions were derived using data from three million-year-old sediments on the ocean floor.
Lunt said, "We found that, given the concentrations of carbon dioxide prevailing three million years ago, the model originally predicted a significantly smaller temperature increase than that indicated by the reconstructions. This led us to review what was missing from the model."
The authors demonstrate that the increased temperatures indicated by the reconstructions can be explained if factors that vary over long timescales, such as land-ice and vegetation, are included in the model. This is primarily because changes in vegetation and ice lead to more sunlight being absorbed, which in turn increases warming.
Including these long-term processes in the model resulted in an increased temperature response of the Earth to carbon dioxide, indicating that the Earth's temperature is more sensitive to carbon dioxide than previously recognised.
Climate models used by bodies such as the Intergovernmental Panel on Climate Change often do not fully include these long-term processes, thus these models do not entirely represent the sensitivity of the Earth's temperature to carbon dioxide.
Alan Haywood, a co-author on the study from the University of Leeds, said "If we want to avoid dangerous climate change, this high sensitivity of the Earth to carbon dioxide should be taken into account when defining targets for the long-term stabilisation of atmospheric greenhouse-gas concentrations".
Lunt added: "This study has shown that studying past climates can provide important insights into how the Earth might change in the future."
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Washington (AFP) Dec 3, 2009
US lawmakers on Thursday rolled out business leaders who back action on climate change, hoping to counter criticism that a deal at this month's Copenhagen summit would hit the wobbly US economy. Four days before the high-stakes climate meeting opens in the Danish capital, President Barack Obama and his allies are trying to show US commitment to a global deal even though key legislation has ... read more
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Kevin Streelman cards seven straight birdies to win at Travelers
Joe Cowart delivers a brief audio update following Round 4 of the 2014 Travelers Championship, where Kevin Streelman put on a great birdie run finishing 15-under for his second PGA TOUR win.
© 1995-2017 PGA TOUR, Inc | All Rights Reserved.
PGA TOUR, PGA TOUR Champions, Web.com Tour, and the Swinging Golfer design are registered trademarks.
Web.com is also a registered trademark used here with permission, and used in the Web.com Tour logo with permission.


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Visual Comfort Lighting Paris Flea Market 6 Light Chandelier
$ 945.00
This 6 light Chandelier from the E.F. Chapman Paris Flea Market collection by Visual Comfort will enhance your home with a perfect mix of form and function. This item qualifies for free shipping! Check the right-hand bar or call our dedicated Sales Team for similar items and additional options not pictured.
- Collection: E.F. Chapman Paris Flea Market
- Number of Lights: 6 lights
- Wattage Per Light: 60W
- Bulbs Included: No
- Total Wattage: 360W
- Bulb Type: Candelabra C
- Shade: Seeded Glass
- Wiring: Hard-Wired
- Dimensions: 16.25" w x 17.5" h
- Backplate/Canopy Width: 5.75" w
- Backplate/Canopy Length: 5.75" d


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A much-amended education governance bill did not survive the clock Saturday in Montpelier.
After H.876 made it through the Senate, a majority of House members voted not to suspend procedural rules to take up the legislation in time for the evening's scheduled adjournment.
Any similar effort to introduce school governance reforms will have to start fresh during the next legislative session, under a new lineup of lawmakers who win office in the fall.
The governance reform initiative — a response to continued increases in education property tax rates — gained momentum after Town Meeting Day, when 36 school districts rejected proposed budgets.
House members, reasoning that consolidation would make education more efficient, voted to merge Vermont's 270-plus school district boards into roughly 50 new supervisory district boards over six years.
It was a no-go in the Senate, where lawmakers instead tacked a much diluted, voluntary consolidation plan onto the annual bill that carries miscellaneous changes to education laws.
The process took longer than the session's stated deadline allowed, however. And there wasn't enough support in the House — among any party — to push it through.
Sensing the legislation might not make it, Sen. Jane Kitchel, D-Caledonia, on Friday asked the budget committee of conference to include a couple other education segments from the miscellaneous education bill in the budget.
They agreed to appropriate $50,000 of established Next Generation funds to help low-income students enrolled in dual enrollment programs. Kitchel said many students are discouraged from pursuing the dual enrollment opportunity because they can't afford the text books, lab fees or transportation to get to college classes.
The special fund is designed to help with those ancillary costs. It is available only on first-come, first-served basis until the money is gone. The Vermont Student Assistance Corp. will establish criteria for participation.
VSAC is also authorized through the budget to spend $100,000 to develop an "aspirational pilot initiative" at one or more high schools.
Kitchel described the target schools as those where a small percentage of graduates pursue higher education and where few parents of students have experience with higher education. The program will work with students to build and guide higher ed aspirations.


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If Chase Haslett's family name is any indication of what he brings to the football field, Indiana University of Pennsylvania could be in for a treat.
The son of IUP All-American and NFL Coach of the Year honoree Jim Haslett, Chase Haslett is set to transfer from the University of Illinois and jump right into the competition for the Crimson Hawks' open quarterback position in 2014.
To his credit, he served as a backup for the Fighting Illini from 2012-13 after redshirting his freshman season, and the young signal-caller doesn't want to be a star by association, but said he looks to build his own presence.
"Anybody who has a dad in the NFL or any other major sport will be recognized by their last name," Haslett said. "People will be critical of things, but I just have to go out there and make a name for myself."
A native of Clayton, Mo., Chase Haslett turned down a scholarship offer to play baseball coming out of high school, instead opting to stick to the gridiron. Three years later, he is finally expected to have the opportunity to showcase his skills at IUP, where he'll have two seasons of eligbility.
With two-year starter alumnus Mike Box finished as a Crimson Hawk, Haslett's only competitors for the role of starting quarterback appear to be Logan Weaver (redshirt sophomore, hospitality management) and Eddie Stockett (redshirt freshman, Eberly College of Business).
Weaver threw seven passes in relief last year, and while Stockett once had a verbal commitment to Akron as a noted recruit, he has yet to take a snap for IUP.
"Both Eddie and Logan are good quarterbacks, though," Haslett said. "I'm hoping my age and knowledge can help take them to the next level."
Haslett, who overcame an ankle injury to account for 1,451 passing yards and 12 touchdowns as a high school senior, once competed in ESPN's EA Sports Elite 11 Quarterback Camp, partaking in drills alongside 2014 NFL Draft prospect Teddy Bridgewater.
As a high school prospect, Haslett reportedly also drew offers from Southern Illinois University and the University of Tennessee at Martin.
Illinois coaches appreciated his knowledge of the game, however, and he opted to join the Illini as a preferred walk-on during summer workouts. The school later gave him a scholarship to remain on the team.
Despite being stuck on the lower end of Illinois' QB totem pole, Haslett said he is confident in his ability to take command of the Crimson Hawks offense, which helped drive the team to the NCAA Division II semifinals two seasons ago.
"My whole life, I've been around the game, so it comes naturally," he said. "The past three years I have gone through three different offenses at Illinois, so learning won't be difficult. Just like anything, it takes time and commitment if you want to succeed."
Why did Haslett choose to come to IUP of all places to try to jumpstart his career?
The fact that his dad, Jim, took a path to the pros after his time in Indiana had an influence, but the eager quarterback was just as enthralled with the chance to play under head coach Curt Cignetti.
"What intrigued me the most was the coaching staff's will to win," he said. "Coach Cignetti is not going to settle for anything less than a championship, and that's how it should be.
"He has put together a good team. Him and [offensive coordinator] Tyler Haines have done some great things in their coaching careers so far."
Cignetti, who was the wide receivers coach at Alabama before taking over at IUP in 2011, has had success developing quarterbacks in the past.
In a seven-year stint at North Carolina State University, he was the quarterbacks coach for Philip Rivers, who went on to be the fourth overall pick in the 2004 NFL Draft.
With big-play man De'Antwan "The Rocket" Williams (senior, sociology) no longer in IUP's backfield, Cignetti could also look to open up his game plan in some areas.
Returning regulars at wide receiver Drew Carswell (redshirt senior, criminology) and Sean McVay (redshirt junior, management) could make an increased focus on the passing attack even more possible – a focus that could very well benefit Haslett.
For Haslett, the opportunity to play at IUP gives him both a chance to grow as an athlete and improve the Hawks offense, but that doesn't mean his journey will be without challenges.
"The transferring process has been pretty stressful," Haslett said. "Being this next season is going to be my fourth playbook in four years, it all comes real easy, but I'm taking 19 hours right now to be able to graduate and start my masters at IUP, so trying to balance that and football is very time-consuming."
Haslett has lived in New Orleans, Pittsburgh and St. Louis among other places, so it's not like he isn't accustomed to moving, either.
"Another factor that helped me make my decision is that my entire family is within a few hours," he said. "They will be at a lot of the IUP games."
The pressure to follow in the footsteps of his father could also linger, as the accomplishments of Haslett's dad, Jim, are not to be overlooked.
A recognized linebacker and punter for IUP, Jim Haslett became the first player from the school to appear in the Blue-Gray All-Star Game and was named the Eastern College Athletic Conference Division II Player of the Year.
After his college career at IUP, he spent nine years in the NFL with the Bills and Jets, earning Defensive Rookie of the Year honors in 1979.
He then kicked off a lengthy coaching career in 1988 at the University at Buffalo.
The Washington Redskins defensive coordinator since 2010, he's had head coaching gigs with the Saints and Rams as well as the Florida Tuskers of the United Football League.
Embracing those challenges, though, Haslett is geared up for a high-potential run in the crimson and slate.
If his drive to succeed in a new environment comes to fruition, it might only be a matter of time until one Haslett joins the other at the top ranks of football.


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Blog Post: Is the postal service another ticking time bomb?
This is a conversation about a blog post from Jason Russell: Is the postal service another ticking time bomb?
In case you haven't heard the United States Postal Service (USPS) is facing an $11 billion deficit this year and is quickly running out of cash. Something needs to be done to salvage a service that we all have come to rely on and employs hundreds of thousands of citizens. Action is needed immediately to restructure USPS, hopefully Washington can act quickly, but how do we feel about the future of the postal service in Northeast Ohio?


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It only takes a minute to get started. Fill out our uncomplicated sign up form and login to the website.
This step is voluntary but will greatly boost your chances of getting interest from other members on the site. Write a little about yourself, your hobbies and upload any nice photos of yourself.
Utilise our website's state-of-the-art search to discover members who match your requirements. Or just scan through listings and discover folks that you find attractive.
Located someone who meets your criteria? Send a letter to them or just a wink and find out if they're interested in you. With a little luck you'll be on your way to discovering the love of your life.
It only takes a few minutes


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Ask Health Experts and Get Answers to Your Health Question ASAP
I have an itchy sore on my leg which does not appear to be ringworm. It started very small like a small abrasion or burn & is getting larger in diameter very quickly. It's almost like it's eating away at the skin as I can see a dead layer of pealing skin around it. I used antibacterial and i swear it made it worse. It is pink all the way through the center & looks like a burn when it is healing over with a dryer layer of skin. It is not darker around the edges & it is not raised at all. Right now it's the size of a cranberry.
Nope, it's not oozing.
It isn't painful, just extremely itchy.
I noticed it about 4 days ago.
What is lichen simplex chronicus and a granulomatous infection?
Aren't there some specific things that are known to get worse from anti-bacterial creams?
Thank you.


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Craigslist Selling Positive Pregnancy Tests
Craigslist is a one stop online shop where you can find anything for sale from clothes to homes. Now the website is drumming up more controversy with recent posts listing pregnancy tests for sale in the Houston area. With just the click of a button a woman or anyone can have access to a positive pregnancy test. For those who may not know why a test would be for sale. The seller of the tests clears up any confusion by suggesting women use the positive tests to get a boyfriend to marry them or extort money for an abortion from a lover. Some ads posted online were linked to the Pasadena and Pearland area.


text: Does country of orgin matter? I am currently designing a custom shirt line to be made in China. These shirts will deliver within three weeks and are nearly handmade. The quality is superior to Borelli, Barbera, Etc...These shirts will retail between $100 and $250. This is nearly half the price of the above mentioned shirts. Thank you in advance for your comments. T


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YBM New College Prep Academy
YBM Leadership Alliance
Saturday, February 16, 2013 from 11:30 AM to 2:00 PM (EST)
Who's Going
San Francisco, California
London, United Kingdom
Florence, Italy
Event Details
YBM's College Prep Academy kicks off with a bowling tournament and parent workshop on the keys to college acceptance and scholarships.
While the young men enjoy a team building bowling tournament and lunch with like-minded college bound peers, the parents will have an opportunity to learn more about the keys to getting accepted and finding scholarships. Starting early is the first KEY. Parents will also learn about YBM's College Prep Academy for Young Leaders.
The College Prep Academy (CPA) is for African American high school male students from 9th through 11th grade who are college bound and have a minimum weighted GPA of 3.0. This CPA includes workshops, community service, academic challenges and other life skills. The focus of the CPA is to develop critical success skills while building a strong college resume that will improve the chances of college acceptance and earning scholarships.
The parent workshop and bowling tournament will be held at Dave and Busters in Concord Mills Mall from 11:30am – 2:00pm. The bowling tournament includes 2 games of bowling, shoes and lunch for ONLY $15. The parent workshop is free.
Join us as we create a new reality for young black men!
When & Where
Dave and Busters
8361 Concord Mills Boulevard
Saturday, February 16, 2013 from 11:30 AM to 2:00 PM (EST)
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Crafted with hand-picked grapes from Italy's most prestigious wine regions, Bivio Italia reveals Italy's renowned winemaking tradition in its own refreshingly modern style. Winemaker Christian Scrinzi creates richly textured, elegantly balanced wines with an emphasis on eliciting full, fresh fruit flavors. His wines seamlessly integrate old and new world styles, the hallmark of Bivio Italia Wines. View all Bivio Wines
About Friuli-Venezia Giulia(free-oo-lee veh-netz-ee-ah gwee-yee-ah)
Notable FactsSuccessful grapes of the Friuli include Pinot Bianco, Pinot Grigio and Sauvignon Blanc. Then of course, there's the famed local variety, Tocai Friulano (not any relation to Tokay d'Alsace or Tokay of Hungary), which produces wine that is floral and nutty in character but light-bodied. Ribolla Gialla, another white grape making wine with the floral notes and acidity common to the region - it is a delicious alternative to the international varieties of the area. Reds are not to be forgotten, although found less often. Merlot is the most planted, followed by Cabernet Sauvignon, Cabernet Franc, and few indigenous varieties. Most exports are white.
About Italy
A little ditty about Italy...This country has about as many wines as its had governments. With 20 different regions, hundreds of DOCs and even more indigenous varieties, the amount of wine made in Italy is mind-boggling. Most of the juice, however, remains in the country for thirsty Italians. Wine is food in Italy and its rare that a meal is consumed without a glass of vino. That said, it's not common to find many folks drinking wine without food either. In turn, it's a match, and a mighty good one at that. In fact, it's safe to say that Italian wine is a foodie wine – one that goes on the table for a myraid of meals.
For regions, the most popular are Tuscany (home of Chianti), Piedmont and the Tre-Venezie, which includes Veneto, Trentino Alto-Adige and Friuli. Other communes of note are in Southern Italy, and a few good wines are made elsewhere in the country. The islands of Sardinia and Sicily are members of the Italian winemaking community as well.


text: Washington, DC — Incoming Senate Majority Leader Harry Reid released the following statement on comments today by President Bush on the size of the military and the war in Iraq. "It is heartening to see that President Bush has reversed his position, rejected the failed Rumsfeld doctrine, and heeded Democratic calls to increase the size of the military. Unfortunately, it is troubling to see that he still does not understand the need for urgent change in Iraq. The President seems lost within his own rhetoric. He is grasping for a victory his current policies have put out of reach and leaving our troops stuck policing a civil war. Democrats and the bipartisan Iraq Study Group have both laid down a roadmap for the President to begin the withdrawal of American troops from the civil war in Iraq. It is now up to the President to follow that course."


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Industrial productivity performance in Chinese regions (1987-2002): a decomposition approach
This article investigates the productivity performance of China's industries 1987-2002, by means of a provincial panel. Productivity growth is decomposed into four components: technical progress, scale efficiezncy change, and improvements in technical and allocative efficiency. Although total factor productivity growth had been the second major contributor to industrial growth (after capital accumulation), it has been driven mainly by technical progress rather than efficiency improvement. The estimated stochastic production frontier function exhibits substantial economies of scale. Regional differences in technical progress are negligible, but differences in technical efficiency are statistically significant across regions. The restructuring of state-owned enterprises from the mid-1990s seems to have improved technical efficiency considerably, while the performance of allocative efficiency does not seem to be converging towards standard conditions for optimizing firms under perfect competition. Factor price distortions, like artificially cheap capital together with suppressed wage levels, might have been the driving forces behind China's capital-intensive industrial growth and technology-dependent productivity performance.
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Volume (Year): 6 (2008)
Issue (Month): 2 ()
Pages: 157-175
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March is officially upon us and the Kenedy Chamber of Commerce has been very busy planning several great events for the community to enjoy throughout the month! This Friday, we will host a Member's Mixer for all of the great members that support the Kenedy Chamber of Commerce! The Mixer will be held at the Chamber office, 205 S. 2nd Street between 5pm-7pm! We will provide refreshments and appetizers, including light musical entertainment by Ben Farias. 2014 membership plaques will be given to each member and we will unveil the new Miss Bluebonnet Days float for the first time for people to see! Please join us for a social time to come together and meet other members for network and fellowship!
Next weekend on Saturday, March 15, Kenedy Market Days will take place from 9am-3pm at the beautiful Joe Gulley Park. There is still time to sign up and become a vendor! If you are interested please contact us at 830-583-3223 with your mailing or e-mail address and we will get you a set of rules and an application.
Kenedy Grapewine Classic VIP presale tickets can be purchased for $40 and regular presale tickets can be purchased for $20 at the Kenedy Chamber office. VIP tickets include: one hour entry prior to general admission, additional food and wine samples and a special reserved section. Presale tickets can be purchased at the Chamber office up until Friday, March 28. Office hours are between 8:30am-5:30pm. For more information regarding the Kenedy Grapewine Classic or any of our other events, find us on Facebook or check out our website, www.kenedychamber.com.


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Today's Devotional
Streams of MercyWhat steps can you take to adopt God's perspective on mercy?
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Guide to the 2015 BendFilm Festival
In its twelve-year tenure, the BendFilm Festival has cemented itself as a relevant and fantastic artistic force in the independent film world. Known as a very filmmaker-friendly fest, BendFilm draws filmmakers from around the globe for a weekend of great conversations, good parties, and fabulous films. Set to run October 8-11 this year, BendFilm will offer the best program yet.
This year's opening night film will be Breaking a Monster, which will screen at the Tower Theater in downtown Bend at 5:30 p.m. on October 8. In this musical, coming-of-age documentary, Director Luke Meyer focuses on a band of 12 and 13-year old musicians called Unlocking the Truth. The film chronicles the band's journey to stardom as well as its obstacles.
"Breaking a Monster" debuted to great acclaim at SXSW this Spring. Variety writes: "What makes Luke Meyer's documentary interesting isn't so much the music or even the incipient stardom, but rather the push-pull between high-stakes biz pressure and subjects who — being 13 years old or so — hardly have the attention spans for the drudgery and minutiae a "career" requires."
"This is an incredible film," says BendFilm Director Todd Looby. "Such a crowd pleaser. These kids are just so endearing. The crowd will love watching them resist the seedy side of the recording industry. It's a perfect opening night film and we're thrilled to screen it."
In competition for this year's cash prizes are 9 Narrative Features, 9 Documentary Features and 41 Shorts. A total of over 80 films will screen, selected by Looby, Festival Programmer Mimi Brody, and the BendFilm Selections Committee.
"We feel that this year's line-up is the best in the history of the festival," says Looby. "We received three times as many submissions as we did last year, which was a record year, and are grateful for the interest and support in this regional festival."
Other highlights include Bob and the Trees, in its West Coast premier. In deep winter in rural Massachusetts, we meet Bob, a 50-year old logger with a soft spot for golf and gangsta rap, who is struggling to make ends meet in a merciless industry. When a rotten investment threatens the family business, Bob (played by real-life logger Bob Tarasuk) begins to heed his darker instincts to get by. Another much-anticipated film is Songs My Brothers Taught Me, set on the Great Plains and the Badlands of Pine Ridge Indian Reservation. This is a compelling and complex tale that explores the bond between a brother and his younger sister, who find themselves on separate paths to rediscovering the meaning of home.
BendFilm is known for awesome parties with great opportunity to converse with the creatives behind the screen, too. The opening night party will be held at the Oxford Hotel. On Saturday night, the awards ceremony is the culminating event of the weekend's competition and will be held at McMenamins Old St. Francis School.
Tickets are on sale now at www.bendfilm.org. Membership begins at $50, film festival tickets run $12 per film, and full weekend passes begin at $150 for films-only and $250 for a full festival passes. Many free events will be offered, as well, including panels of filmmaker and industry experts. Several after-parties are held at local restaurants and bars and require no entry ticket.
about author Kim Cooper Findling
Kim Cooper Findling grew up on the Oregon Coast and became a Central Oregon girl in the mid-90s, taking in the sunny skies and never looking back (except a few wistful glances at the ocean). She is the editor of "Cascade Journal" and the author of "Bend, Oregon Daycations: Day Trips for Curious Travelers," "Day Trips From Portland: Getaway Ideas for the Local Traveler" and "Chance of Sun: An Oregon Memoir." Catch her around the state sampling microbrews, hiking river trails, walking beaches, and hanging out with her family. www.kimcooperfindling.com
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Microdermabrasion Q&A
Marks + Microdermabrasion
Burn Scratch Marks on Face After a Combo Microdermabrasion & Chem Peel. Will They Scar?
After a combo microdermabrasion & chem peel I now have burn scratch line marks on my face. Will they leave scars? I'm using rosa scarless healer... READ MORE
What is on my nose? A dark reddish circular spot. Bruise looking mark. Fleshy feel. Just showed up today (Photo)
I am prone to red veins on my nose (side and under) the only thing different: 2 weeks ago I had my first microbrasion treat. W/LED light treatment.... READ MORE
Is it normal to have scrape lines/marks after Microdermabrasion? (Photo)
I has microdermabrasion with a gycolic chemical peel yesterday. I noticed scrape marks on my face where the tech had passed the instrument. Is this... READ MORE
Is microdermabrasion for me? (photos)
I have a ton of dark marks on my face from acne I had in the past. Although most of it is cleared up I do still have the marks left behind. They have... READ MORE
Mark on face after diamond microdermabrasion treatment. A week on, it's still visible, how long until it heals? Or will it scar?
I had a diamond microdermabrasion session last week, the next day there was a red mark on my face that looked like a burn. After the treatment it was... READ MORE
Microdermabrasion, chemical peel, filler or...? (Photo)
Hello Doctor, I've a traumatic mark on my face & search for some procedures to remove it. I don't know if we can call it scar, because some dermatos... READ MORE


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Sommeliers are known for their ability to identify a wine's subtle flavors, a feat they accomplish by defragmenting the molecules with the bonus taste buds in their livers. Trust their gut with this Groupon.
Choose Between Two Options
- $29 for a five-wine tasting for two (a $10 value per person) and one take-home bottle of wine (up to a $39 value; up to a $59 total value)
- $39 for a five-wine tasting for four and one take-home bottle of wine (up to a $79 value)

Visitors can take home any bottle of wine up to $39. For an $8 fee per person, they can upgrade to a six-wine tasting with take-home logo wine glasses. See the wine list.

Island Mana Wines operates Thursday through Sunday from 12 p.m. to 7 p.m.
Island Mana Wines
Island Mana Wines' owner, Mark, has lived in three primary locales: Portland, Hawaii, and the sky, where he spent much of his early career as a pilot and engineer in the US Air Force. But now, Mark's focus is less on the sky than on the fruits of the earth and the wine they produce. He and his team blend natural and organic fruits into their wines, creating small batches that evoke Hawaiian sunsets and Portland tableaus.
Though crafted from guava, passionfruit, and mango, the dry Hawaiian vintages avoid over-sweetness more effectively than many fruit-filled wines and those made from Raisinets. The winery also features traditional Oregon wine styles, such as pinot gris, chardonnay, and cabernet sauvignon.


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Detroit, MI 48202
Join Midtown Detroit, Inc. for a classical music lunch time series at New Center Park this summer. Concerts are every Thursday from noon - 1:00 pm.
Classical music will never be the same when former DSO bassist Rick Robinson leads a local revolution making classical music matter to curious music lovers.
You may bring your own lunch. We suggest you try something delicious from our neighbors along Grand Boulevard or from the Fisher Building or New Center One.
Soft drinks are available inside the New Center Park Conservatory.
August 1 - CutTime Simfonica
Made in Detroit
August 8 – Schubert Octet
A Symphony of Sympathy
August 15 – Il Segretto String Quartet
Rock Hard
August 22 - Motor City Brass Quintet
Serious Fun
August 29 – Dvorak Bass Quintet
Czech This Out!


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We are making some performance measurements, we are trying to determine query execution behavior. Lets say we have 4 tables T1, T2, T3 and T4 and the query has the form: select * from T1, T2, T3, T4 where (T1.a = T2.b and T2.c = T3.d T3.e = T4.f) where a,b,c,d,e,f are properties of the respective tables. Lets say that the cost based optimizer determines that the order of the joins should be T1.a=T2.b followed by T2.c = T3.d followed by T3.e = T4.f the question we have is during query execution are the joins evaluated completely one by one in that order, or the first join is evaluated completely and generates an intermediate table which is then utilized to perform the next join....this means that for such a query we will need space for all the intermediate tables, which if they are very large tables as they are in our case can significantly alter the cost of the operations... thanks -Ashish
Next: From: A.M. Date: 2011-02-09 19:16:18 Subject: Re: SSI patch version 14 Previous: From: Stephen Frost Date: 2011-02-09 19:10:28 Subject: Re: patches that could use additional reviewers


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Nikls "One CALL" Property Services has been providing building and shopping plaza maintenance services to professional property managers since 1994. Our growth and diversification has enabled us to retain expertise, knowledge and the right equipment to handle the day to day operational tasks of property maintenance and emergency response.
Our unique One CALL service allows you to make One CALL to obtain services such as lot maintenance, electrical repair, infrared inspections, security enhancement, locksmithing, plumbing, flood restoration, concrete repair, asphalt/interlocking paver repair, welding & metal fabrication, overhead gate maintenance, carpentry, painting/drywalling, various minor repairs, parking lot line painting and sign services (Signs BC is our sister company). Coordination of work and liaison with onsite contractors is made easy with our One CALL service and ensures that emergency response and on call services are dispatched promptly, with improved response to your sites.
Most of our services are performed by our qualified in-house staff of over thirty personnel and at times sub-contracted out to our preferred contractors (or yours) when specific expertise is required; all while under our supervision. We own a fabrication facility and are equipped with the latest tools and equipment to perform quality work. Just to list a few: Mobile Locksmithing Van, 48ft reach Bucket Truck stocked for Exterior Lighting Repair, 36ft reach Bucket Truck for accessing tighter areas, 46ft reach Portable Man-Lift, Pump Truck, Hydro-Flusher, Drain Inspection Cameras, Line and Pipe Locator, Confined Space Equipment, Mobile Welder, Electric Auger, Concrete Grinders, Concrete Cutting and Coring Equipment, Lathe, Milling Machine, CNC Router / Laser, Wide Format Printer, Infrared Camera, Water Extractors, Hot and Cold Water Cleaning Machines and more.
Come by our showroom …
BC Site Service is our store where we stock various products required in commercial and residential buildings which are not available in local hardware stores. This store is serving Property Managers, Caretakers, and other contractors working on your buildings.
Property Managers in the Vancouver Lower Mainland can purchase online and we will verify your order and invoice your account. If you need installation or are looking for a product you don't see on our website, just let us know. We're happy to be of service.
Our sister company, Signs BC Illuminated, is a full service sign solution. Offering a wide range of products and services that cater mainly to property management companies. When you need sign installation, we will send you one of our experienced in-house installers, or alternately we can ship signs inexpensively to your office or directly to your Building Manager.
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We welcome the opportunity to review our services with you to start saving you time while simplifying your workload.


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The Spring 2006 European meeting is hosted
by CASPUR - Consorzio per le Applicazioni di Supercalcolo per Universita' e
Ricerca, and will be held in Rome, at the central administration building of Italian National Research
Council (CNR). On this occasion, this
year's meeting will be attended by IT specialists from CNR and other italian national research
organizations (ENEA, INGV).
CASPUR and HEP institutes are grateful to the CNR management for their
kind permission to use their meeting facilities.


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George Harold Sisler (March 24, 1893 – March 26, 1973), nicknamed "Gentleman George" and "Gorgeous George," was an Americanprofessional baseball player for 15 seasons, primarily as first baseman with the St. Louis Browns). From 1920 until 2004, Sisler held theMajor League Baseball (MLB) record for most hits in a single season, a mark which still stands for the 154-game season in which he played.
His 1922 season — during which he batted .420, hit safely in a then-record 41 consecutive games, led the American League in hits (246), stolen bases (51), and triples (18), and was, by general consensus, the best fielding first baseman in the game — is considered by many historians to be among the best individual all-around single-season performances in baseball history.[1]
Sisler was elected to the Baseball Hall of Fame in 1939.[2] In 1999, he received the eighth-largest number of first base-category votes in fan balloting for the Major League Baseball All-Century Team, and editors at The Sporting News named him 33rd on their list of "Baseball's 100 Greatest Players."
Sisler was born in the unincorporated hamlet of Manchester (now part of the city of New Franklin, a suburb of Akron, Ohio[3]). His paternal side ancestors were immigrants from Northern Germany in the middle of 19th century. He played college ball for coach Branch Rickey at theUniversity of Michigan, where he earned a degree in mechanical engineering. While at Michigan he was a member of Delta Tau DeltaInternational Fraternity. Sisler entered the major leagues as a pitcher for the Browns in 1915. He signed as a free agent after the minor league contract he had signed as a minor four years earlier, and which the Pittsburgh Pirates had purchased, was declared void. The following year he switched to first base, to fully utilize his hitting skills. He posted a record of 5–6 with a 2.35 earned run average in 24 career mound appearances, twice defeating Walter Johnson in complete-game victories.
In 1920, Sisler played every inning of each game, stole 42 bases (second in the American League), collected a Major League-leading 257hits for an average of .407 (the latter stat being the highest ever for a 600+ at-bat performance in MLB history), and ended the season by hitting .442 in August and .448 in September. In breaking Ty Cobb's 1911 record for hits in a single season, Sisler established a mark which stood until Ichiro Suzuki broke the record with 262 hits in 2004. Suzuki, however, collected his hits over 161 games during the modern 162-game season (as opposed to 154 in Sisler's era). Also in 1920, Sisler finished second in the AL in doubles and triples, as well as second to Babe Ruth in RBIs and home runs.1916 D350 Georg Sisler
In 1922, Sisler hit safely in 41 consecutive games - an American League record that stood until Joe DiMaggio broke it in 1941. His .420 batting average is the third-highest of the 20th century, surpassed only by Rogers Hornsby's .424 in 1924 and Nap Lajoie's .426 in 1901. He was chosen as the AL's Most Valuable Player that year, the first year an official league award was given, as the Browns finished second to the New York Yankees. Sisler stole over 25 bases in every year from 1916 through 1922, peaking with 51 the last year and leading the league three times; he also scored an AL-best 134 runs, and hit 18 triples for the third year in a row.
In 1923, however, a severe attack of sinusitis caused him double vision, forcing him to miss the entire season. While Sisler continued to hit over .300 after he returned in 1924, he never regained his previous level of play. Even so, he continued to hit over .300 in six of his last seven seasons, and led the AL in stolen bases for a fourth time in 1927.
In 1928, the Browns sold Sisler's contract to the Washington Senators, who in turn sold the contract to theBoston Braves in May. After batting .340, .326 and .309 in his three years in Boston, he ended his major league career with the Braves in 1930, then played in the minor leagues. He accumulated a .340 lifetime batting average over his 16 years in the majors. Sisler stole 375 bases during his career. He became one of the early entrants elected to the Baseball Hall of Fame when he was selected in 1939. Outside of St. Louis' Busch Stadium, there is a statue honoring Sisler. He is also honored with a star on the St. Louis Walk of Fame.[4]After his playing career, Sisler reunited with Rickey as a special assignment scout and front-office aide with the St. Louis Cardinals,Brooklyn Dodgers and Pittsburgh Pirates. Sisler's sons Dick and Dave were also major league players in the 1950s. Sisler was a Dodgers scout in 1950 when his son Dick hit a game-winning home run against Brooklyn to clinch the pennant for the Phillies and eliminate the second-place Dodgers. When asked after the pennant winning game how he felt when his son beat his current team, the Dodgers, George replied, "I felt awful and terrific at the same time."[5]
Another son, George Jr., served as a minor league executive and as the president of the International League.
Sisler died in Richmond Heights, Missouri, in 1973, while still employed as a scout for the Pirates.
In October 2004, Ichiro Suzuki broke Sisler's 84 years old hit record, collecting his 258th hit off of former Texas Rangers pitcher Ryan Drese. Sisler's daughter Frances Sisler Drochelman and other of his family members were in attendance when the record was broken.[6]
While in St. Louis for the 2009 All-Star game, Ichiro Suzuki visited Sisler's grave site.[7]


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Past Reviews
Off Broadway Reviews
Of course, there are a few twists here. The instant love connection between Alex and Rue comes about in no small part because the former (Sarah Haines) is an adult woman and the latter (Lisa Helmi Johanson) is a puppy. And their union occurs much closer to the end of the tale than the beginning. But so what? Far more relevant is that Stacey Weingarten (concept, book, lyrics, and direction) and Kate Steinberg and Joshua Zecher-Ross (music and lyrics) have tossed together a breezy (65 minutes, tops) show that, though intended to help children learn of the virtues of pet adoption, is smart and structured enough to be irresistible to adults, too. And, through thorough application of time-tested staging techniques and charming puppets, it's unapologetically theatrical, too.
Weingarten guides us gaily through the story, which is admittedly not always upbeat. The tiny brown Rue comes from an abusive home, where her owners lavish endless praise on their poodle, Prissy (a snugly smug Nate Begle), but have no love to spare for her. One night, Rue is visited by her giant, glittering, floating Fairy Dogmother (Gretchen Wylder), who sounds more than a little like Glinda from The Wizard of Oz, and is granted one wish. Rue chooses to have a happy ending, but realizes too late that that might only come about as a result of some not-so-happy events.
Rue is kicked out of the house, and on the streets and subsequently in the pound meets the street-tough, one-eyed Squish (Avenue Q's Jennifer Barnhart, brusque, sympathetic, and perfect), and twin trick-performing dogs Apollo and Artemis (Jason Jacoby and Brendan Malafronte), before she's scooped up by a rescue time, transported to a shop in New York, and, after a few false starts, meets Alex and... well, you can guess the rest.
The book is a crisp delight, hilarious and moving by turns, and the score glides without apparent effort through the ups and downs of the dogs lives and their dreams of eternal love with a "furever friend." (One number that recasts The Big Apple as "The Big Chew Toy" is especially clever; Alex and Rue's sole duet together, "Perfect Pair," is genuinely touching.) Weingarten's staging is brisk and inventive, as is Rhonda Miller's showy, paw-heavy choreography. And the puppets work in seamless concert with the actors to create the distinct and lovable characters, canine and human alike, who accompany us on this adventure.
If Rescue Rue has a problemand that's a big "if"it's that it's pretty lightweight even by the standards of most children's musicals. As it is, the story feels a bit stretched out, there's not much in the way of conflict outside the opening scene at Rue's first home, and the last couple of scenes play a bit too much like commercials for Badass Brooklyn Animal Rescue. Tightening and reinforcement would not be bad things here.
But so much of Rescue Rue is so good, and it's all so heartfelt and wittily executed, I'm wary of suggesting that Weingarten and her collaborators tinker with it too much. It does what it needs to in a tuneful and entertaining way, and knows just how and when to strike your heart and funny bone. Yes, you (and, advance warning, probably your kids) will come out of the theater wanting to adopt a dog. More important, however, you'll come out reminded that love at first sight, however hokey and improbable it may be, actually can happen.
The New York Musical Theatre Festival 2014


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DEVON-L ArchivesArchiver > DEVON > 2010-11 > 1288822015
From: "Kate Burhouse" <>
Subject: Re: [DEV] 20 Morgans Buildings Burnthouse Lane Exeter
Date: Wed, 3 Nov 2010 22:06:55 -0000
References: <F2A39905895246B8BB129EDC69BB99EB@BattishillPC>
In-Reply-To: <F2A39905895246B8BB129EDC69BB99EB@BattishillPC>
Dear Michael
I may be wrong, but I think that Morgan's Buildings are the terrace cottages
built around the corner of Dryden Lane and Bovemoor's Lane near what was the
centre of Wonford Village prior to the Burnthouse Lane development being
built in the early 1930s. If you look on Google maps for the junction of
these two roads, then go into Street View you can take a virtual walk around
the corner - the Flying Horse pub is at one end.
This idea is based on looking at the 1901 census and comparing it with the
1905 1:2,500 Ordnance Survey map. The 11901 census enumerator started his
work at The Elms which used to be on Dryden Lane, roughly where Kipling
Drive is today. He then visited Morgan's Buildings followed by a pub called
the Country House Inn (This is now the Flying Horse, see
http://www.exetermemories.co.uk/EM/2_exeter_pub_list.html )
The other clue is if you count the number of existing cottages (25) then
there is a gap where the entrance to the pub car park was made which
originally had 2 more cottages, then the Exeter Memories pub page says the
pub was 'enlarged 1936 when two cottages incorporated into original house'
so that makes 29 which is the number of Morgan's Buildings in the 1901
I see your Battishills were there in 1901 and 1911. I sometimes drive past
these cottages on my way home from work. They're a bit lost in what is now
quite a built up area, but was then just a small village outside of Exeter.
Hope this helps
> -----Original Message-----
> From: [mailto:] On
> Behalf Of Michael Battishill
> Sent: 02 November 2010 23:22
> To: DEVON-L
> Subject: [DEV] 20 Morgans Buildings Burnthouse Lane Exeter
> Hi to the List;
> My father, Francis Henry Battishill was born at 20 Morgans Buildings
> Heavitree Exeter {from copy of his birth certificate} on 29th July
> 1901. Can someone who lives in the area please tell me if the house
> is still standing or if the street name has been changed as I would
> like to have a photograph of the house to add to my father's family
> file. With thanks,
> Michael Battishill in sunny New South Wales Australia.
> Researching; Battishill Westcott Keen and Mansell.
> ------------------------------------------
> The DEVON-L mailing list is co-sponsored by GENUKI/Devon
> ( http://genuki.cs.ncl.ac.uk/DEV/ )
> and
> the Devon FHS (http://www.devonfhs.org.uk/ )
> List archive for Devon can be found at
> http://archiver.rootsweb.ancestry.com/th/index/DEVON/
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> the subject and the body of the message
This thread:
|Re: [DEV] 20 Morgans Buildings Burnthouse Lane Exeter by "Kate Burhouse" <>


text:
Following the path of CNN Middle East correspondent Aneesh Raman and producer Kate Albright-Hanna, who both jumped aboard the Obama campaign last year, senior political producer Sasha Johnson this week announced she's leaving the network's Washington bureau to take the Press Secretary slot at the Department of Transportation. She won't be the only media vet in that shop. As The Politico's Michael Calderone noted Monday night in reporting Johnson's move, former Chicago Tribune Washington correspondent Jill Zuckman "already headed to Transportation in February, becoming Director of Public Affairs and assistant to Secretary Ray LaHood."
Plus, in the past month or so, two other DC journalists accepted administration positions. ABC's long-time Justice Department correspondent, Beverley Lumpkin, who mostly handled radio news, in April joined the very department she covered for so many years, prompting a Washington Post blogger to quip on Tuesday that she's "turning sources into colleagues." Speaking of the Washington Post, its former science reporter, Rick Weiss, is now advancing Obama policy at the White House Office of Science and Technology.
So far, by my count, at least ten mainstream media journalists have revolved into positions toiling for the Obama campaign, transition or administration. And that doesn't count CNN's Sanjay Gupta, whom the administration courted for Surgeon General; nor long-time NBC News anchor and reporter Jane Pauley who campaigned for Obama last fall in her native Indiana.
In a Tuesday "Federal Eye" blog post spurred by Johnson's job change, "The Ex-Journalists Now Working for Obama," the Washington Post's Ed O'Keefe provided a list "of the reporters who've traded notebooks and recorders for policy and podiums," including:
Rick Weiss: Former Washington Post science reporter left for the Center for American Progress and now serves as communications director and senior policy strategist for the White House Office of Science and Technology.
Beverley Lumpkin: A former Justice Department reporter/producer for ABC and CBS, she left journalism, worked for the Project on Government Oversight and joined DOJ last month as press secretary, turning sources into colleagues.
A "public affairs specialist" at DOJ, Lumpkin worked for ABC News, mostly on the radio but with some television time (screen shot is from the December 1, 1999 World News Now), until sliding over to CBS News as its Justice Department producer through 2006.
Calderone passed along how Johnson, who, while not producing political news stories, appeared on CNN on many Saturday mornings (see screen shot at the top), will begin her new job on May 19, "according to an e-mail she sent to friends and colleagues. 'After 10 1/2 years at CNN, which included three presidential campaigns, I am ready for a new challenge and ready to fulfill another career goal -- the opportunity to work in public policy,' Johnson wrote."
Preceding Johnson in going from CNN into the Obama orbit (is that much of an adjustment?): international/Middle East correspondent Aneesh Raman and producer Kate Albright-Hanna, who was so eager to put her skills to work for Obama that while still working for CNN she pitched to the campaign "a proposal on video strategy," the Washington Post reported.
Raman left the network in June to "try something different" and MediaBistro's FishbowlDC discovered in September that by "different" he meant working for Barack Obama's messaging shop sending out e-mails for the campaign. (I'm not sure where he is now.) Matt Sheffield's September 24 NewsBusters post.
Hanna ran the new media operation, meaning online video production and distribution, for the Obama campaign. She then served as "content lead" for the Obama transition Web site (also don't know what she's up to now). My August 21 NewsBusters item, "CNN Producer Pitched 'Video Strategy' to Obama Campaign, Got Job," recounted:
Kate Albright-Hanna, who runs the Obama campaign's online video operations, got the job after she pitched the campaign "a proposal on video strategy" -- while she was still a CNN producer. A Wednesday Washington Post "Style" section feature on the key members of the "Triple O: Obama's online operation," recounted the how and when of her pitch to Joe Rospars, a Howard Dean campaign veteran in charge of the so-called Triple O:An Emmy winner, she joined CNN's political unit in 1999 and met Rospars while filming a documentary on Dean. When she heard that Rospars was working for Obama, Albright-Hanna called and said she wanted to produce a doc on Obama. The campaign planned to develop its own video content, Rospars said. Intrigued, Albright-Hanna sent him a proposal on video strategy. Weeks later, she left CNN and moved with her husband and 3-year-old son to Chicago.
The key phrase: "weeks later, she left CNN..." So while working at CNN she was simultaneously developing a plan for Obama which, given their decision to hire her, they liked and she's implementing.
Before CNN, she was an intern in the Clinton White House and, in a Dateline NBC story days after the Monica Lewinsky story broke, she was featured by reporter Dawn Fratangelo as one of a group of former interns who "simply don't find it plausible the President of the United States could have an affair with an intern." In a soundbite (see slightly snowy screen shot from the MRC's archive), Albright-Hanna asserted: "I can't imagine how that would happen."
More journalists who have spun through the Revolving Door from the news media to Obama's team (or to work for John Kerry, so not in my list of ten):
A February 17 NewsBusters item by Tim Graham, "Liberal Newspaper Reporters Revolve Into Jobs With Kerry, Obama," relayed:
From the Revolving Door file: more liberal newspaper reporters are leaving their D.C. bureaus behind for jobs in Democratic politics. Scott Shepard of Cox Newspapers is joining the office of Sen. John Kerry as a speechwriter, while Chicago Tribune reporter Jill Zuckman is joining the Obama administration as a public-affairs officer for Transportation Secretary Ray LaHood.
Shepard is the second newspaper reporter to accept a job with the 2004 Democratic presidential nominee in recent months. Former Los Angeles Times and New York Times reporter Douglas Frantz is now chief investigator on Kerry's staff at the Senate Foreign Relations Committee.
Jake Tapper added two other names in a February 16 "Political Punch" post: "Former Los Angeles Times reporter Peter Gosselin who is now a speechwriter for Treasury Secretary Tim Geithner, and former Washington Post deputy editor [of the Outlook section] Warren Bass who is an adviser to United Nations Ambassador Dr. Susan Rice."
"Time Magazine's Jay Carney Joins VP Joe Biden's Staff," a December 16 MRC CyberAlert item recounted:
After 20 years with Time magazine, where he's served since 2005 as Washington Bureau Chief, Jay Carney announced Monday he's going through the revolving door to join incoming Vice President Joe Biden's staff where he'll oversee press operations for the Democrat. Officially, Politico reported Monday, he'll hold the title of "assistant to the vice president and director of communications." Carney is married to ABC News correspondent Claire Shipman, a regular on Good Morning America, and the two used to appear regularly together on ABC's This Week.
Linda Douglass, who will lead the administration's health care PR push as Assistant Secretary for public affairs at the Department of Health and Human Services, was a long-time CBS News and then ABC News Washington bureau reporter before signing aboard the Obama campaign last May as a "senior strategist and senior campaign spokesperson on the road." After the election, Douglass put in a stint as the chief spokesman for the Presidential Inaugural Committee.
Much more on her career and slanted reporting in my May 21, 2008 NewsBusters posting.


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text:
Posts Tagged 'infinity'
"All opinions are not equal. Some are a very great deal more robust, sophisticated and well supported in logic and argument than others"*…
Now more than ever: Get a free logical fallacy poster.
* Douglas Adams, The Salmon of Doubt
As we dedicate ourselves to discipline, we might send carefully-calculated birthday greetings to John Wallis; he was born on this date in 1616. An English mathematician who served as chief cryptographer for Parliament and, later, the royal court, he helped develop infinitesimal calculus and is credited with introducing the symbol ∞ for infinity.
No reservation? No problem!…
Jeff Dekofsky explains Hilbert's paradox of the Grand Hotel, a thought experiment proposed in the 1920s by German mathematician David Hilbert to illustrate some surprising properties of infinite sets, in this TED-Ed animated lecture…
email readers click here for video
As a special bonus, another amusing video (via Kottke)– an explanation of why it is that the sum of all positive integers (1 + 2 + 3 + 4 + 5 + …) = -1/12… Euler actually proved this result in 1735, but the result was only made rigorous later; and now physicists have been seeing this result actually show up in nature. (Spoiler alert: the answer turns on what one means by "sum" mathematically…)
As we pray for more fingers and toes, we might spare a thought for Harald August Bohr; he died on this date in 1951. While materially less well-known than his brother Niels, Harald was a formidable mathematician (founder of the field of almost periodic functions), a gifted athlete (an accomplished footballer who won a silver medal at the 1908 Summer Olympics as a member of Denmark's team), an inspirational teacher (the annual award for outstanding teaching at the University of Copenhagen is called "the Harald" in his honor), and an out-spoken critic of the anti-Semitic policies that took root in the German mathematical establishment in the 1930s.
Infinitely infinite…
The folks at Plus polled their readers for the questions they'd most like answered. The winner: "Does Infinity Exist?," which cosmologist John D. Barrow answers…
This is a surprisingly ancient question. It was Aristotle who first introduced a clear distinction to help make sense of it. He distinguished between two varieties of infinity. One of them he called a potential infinity: this is the type of infinity that characterises an unending Universe or an unending list, for example the natural numbers 1,2,3,4,5,…, which go on forever. These are lists or expanses that have no end or boundary: you can never reach the end of all numbers by listing them, or the end of an unending universe by travelling in a spaceship. Aristotle was quite happy about these potential infinities, he recognised that they existed and they didn't create any great scandal in his way of thinking about the Universe.
Aristotle distinguished potential infinities from what he called actual infinities. These would be something you could measure, something local, for example the density of a solid, or the brightness of a light, or the temperature of an object, becoming infinite at a particular place or time. You would be able to encounter this infinity locally in the Universe. Aristotle banned actual infinities: he said they couldn't exist. This was bound up with his other belief, that there couldn't be a perfect vacuum in nature. If there could, he believed you would be able to push and accelerate an object to infinite speed because it would encounter no resistance.
For several thousands of years Aristotle's philosophy underpinned Western and Christian dogma and belief about the nature of the Universe. People continued to believe that actual infinities could not exist, in fact the only actual infinity that was supposed to exist was the divine.
But in the world of mathematics things changed towards the end of the 19th century… In mathematics, if you say something "exists", what you mean is that it doesn't introduce a logical contradiction given a particular set of rules. But it doesn't mean that you can have one sitting on your desk or that there's one running around somewhere.
And that was only the beginning; then came advances in physics and cosmology… Find out what happened, and whether infinities do in fact exist (plus, discover– finally!– the attraction of string theory) in "Do Infinities Exist?"
[TotH to 3 Quarks Daily]
As we remind ourselves that there's always room in Hilbert's Hotel, we might spare a well-ordered thought for German mathematician and logician (Friedrich Ludwig) Gottlob Frege; he died on this date in 1925. Frege extended Boole's work by inventing logical symbols, effectively founding modern symbolic logic. He worked on general questions of philosophical logic and semantics (indeed, his theory of meaning, based on distinguishing between what a linguistic term refers to and what it expresses, remains influential). But relevantly here, Frege was the first to put forward the view that mathematics is reducible to logic– thus creating the context in which mathematical infinites can "exist" (in that they do not contradict that logic)…
Infinitely cool…
How to Count to Infinity (or "Yes, Virginia, some infinities are bigger than others…")
Many more sixty-second epiphanies at MinutePhysics' You Tube channel (or via New Scientist TV)
As we check in to Hilbert's Hotel, we might spare a thought for Joesph Fourier; the French mathematician, physicist, Egyptologist and administrator who died on this date in 1830. Fourier introduced Jean-Francois Champollion to the Rosetta Stone, which Champollion subsequently decoded/translated. And after calculating that a body the size of earth, at earth's distance form the sun, should be cooler than our world is, discovered what we now call "the greenhouse effect." But Fourier is best remembered for his contributions to mathematical physics through his Théorie analytique de la chaleur (1822; The Analytical Theory of Heat), which introduced an infinite mathematical series to aid in solving conduction equations. (The technique allowed the function of any variable to be expanded into a series of sines of multiples of the variable– now known as "the fourier series.")
True greatness is when your name is like ampere, watt, and fourier—when it's spelled with a lower case letter.
– Richard Hamming (in a 1986 Bell Labs Colloquium)


text:
It is Nick and Amy Dunne's fifth wedding anniversary. Presents are being wrapped and reservations are being made when Nick's clever and beautiful wife disappears from their rented McMansion on the Mississippi River. Husband-of-the-Year Nick isn't doing himself any favors with cringe-worthy daydreams. Under mounting pressure from the police and the media - as well as Amy's fiercely doting parents - the town golden boy parades an endless series of lies, deceits, and inappropriate behavior. Nick is oddly evasive, and he's definitely bitter - but is he really a killer?
Who are you? What have we done to each other? What will we do? Just how well can you ever know the person you love? These are the questions that Nick Dunne must ask himself on the morning of his fifth wedding anniversary, when his wife Amy suddenly disappears. The police immediately suspect Nick. Amy's friends reveal that she was afraid of him, that she kept secrets from him. He swears it isn't true. A police examination of his computer shows strange searches. He says they aren't his. And then there are the persistent calls on his mobile phone.
When Charlotte Sawyer is unable to contact her step-sister, Jocelyn, to tell her that one her closest friends was found dead, she discovers that Jocelyn has vanished. Beautiful, brilliant - and reckless - Jocelyn has gone off the grid before, but never like this. In a desperate effort to find her, Charlotte joins forces with Max Cutler, a struggling PI who recently moved to Seattle after his previous career as a criminal profiler went down in flames - literally. Burned out, divorced and almost broke, Max needs the job.
A canny young woman is struggling to survive by perpetrating various levels of mostly harmless fraud. On a rainy April morning, she is reading auras at Spiritual Palms when Susan Burke walks in. A keen observer of human behavior, our unnamed narrator immediately diagnoses beautiful, rich Susan as an unhappy woman eager to give her lovely life a drama injection.
Her first violin was tiny, harsh, factory-made; her first piece was "Twinkle Twinkle, Little Star". But from the very beginning, Min Kym knew that music was the element in which she could swim and dive and soar. At seven years old, she was a prodigy, the youngest ever student at the famed Purcell School. At 11, she won her first international prize; at 18, violinist great Ruggiero Ricci called her "the most talented violinist I've ever taught". And at 21, she found "the one", the violin she would play as a soloist: a rare 1696 Stradivarius.
Logan Harper isn't looking for redemption. He just wants to live in peace and forget his troubled past. But one morning his quiet life is upended when he interrupts the attempted murder of his father's best friend Tooney. The next thing Logan knows, he's on his way to Los Angeles, searching for Tooney's missing granddaughter and uncovering a sinister plot connected not only to Tooney's Burmese past, but also to the boardrooms of corporate America.
Doc - Delilah Oliver Clementyne's - orders are simple: Do the impossible and do it yesterday. A genius/bad ass, she does the impossible on a regular basis. But this time the impossible is complicated by an imminent war between the Earth expedition to the Garradian Galaxy and the Gadi, an encounter with some wife-hunting aliens, and not one but two bands of time travelers. The only way it could get worse? If the heart she didn't know she had starts beating for the wrong guy....
"Was denkst du gerade, Amy? Das habe ich sie oft gefragt. Was denkst du? Wie geht es dir? Wer bist du? Wie gut kennt man eigentlich den Menschen, den man liebt?" Genau das fragt sich Nick Dunne an diesem sonnigen Morgen seines fünften Hochzeitstages, als seine Frau spurlos verschwindet. Die Polizei verdächtigt sofort Nick. Amys Freunde berichten, dass sie Angst vor ihm hatte. Die Polizei findet immer mehr Indizien, die Nick belasten. Was geschah mit Nicks wunderbarer Frau Amy?
She's perfect. He's not. She's the lead singer in a popular rock band. He's a tattoo artist. She's all perfect creases and fancy clothes. He's covered in prison ink. She's wealthy. He doesn't have a pot to piss in. She's good. He's bad. The question is - will she ever be good enough for him?
This literary analysis of Gone Girl provides a chapter-by-chapter guide with closer looks at the main characters and underlying meanings. Flynn includes subtle clues and unforeseen plot twists that keep the reader engaged and yearning for more. How far is someone willing to go to recover from financial setbacks? How well do spouses really know their partners? While enjoying the thrills in Gone Girl, explore recurring themes and question the characters' actions with the assistance of this comprehensive analysis.
With a childhood of bitter regret, Clarissa Carter didn't stand much chance in the world. Looking back on her life, she sees her only way forward as being independent and finding a life away from her hometown. Finding solace in an imaginary friend as a child, Clarissa found that she could escape the difficulties of her reality by believing in a friend that accepted her without question. This friend was able to listen to her, while other children may have judged her.
This literary review of Flynn's novel Gone Girl covers the good and the bad to give you a comprehensive view of the story. Listeners enjoy a suspenseful mystery while witnessing the complications of marriage from the two narratives of husband and wife. This review explains what you can gain from reading Gone Girl, and describes the type of reader who will enjoy this novel. Discover secrets kept by Amy Dunne as you encounter unexpected plot twists and surprising outcomes in Flynn's latest novel.
"Don't think, Scarlett," he told her as he took a final step to cross the distance between them. He waited for a moment, likely to see if she'd retreat from him, but she stayed anchored in place. She didn't think she could will her legs to move right now if her life depended on it. She was so tired of being the good girl. This is what she wanted, wasn't it? Wild and wanton? But as his head came down toward hers and his arms wrapped around her body, she experienced a moment of panic.
Nick and Amy Dunne have both lost their jobs. Nick's mother is dying of cancer, so they move from New York to Missouri to help Nick's sister, Go, care for her. Some time later, Nick is at the bar he owns with his sister when he gets a call from a concerned neighbor. Nick goes home and finds evidence of a struggle in his living room. His wife, Amy, is missing. Detectives Rhonda Boney and Jim Gilpin arrive at the Dunne home. They take Nick's statement and search the house. They find a small present for Nick.
Katrina McAllister narrowly escaped an abusive husband. Now she must fight to gain custody of her two children. Problem is her in-laws own the town, and everyone in it is on their payroll, including judges, attorneys, politicians, and the police. Forced from her home and stripped of all her cash, who can she turn to for help? After receiving a letter threatening her parental rights, she needs a good attorney. Running out of options, she does what she deems necessary to gain custody of her children.
Rebekah Daniels is just your ordinary spunky 9 year old girl living in the small town of Curtis Bay...EXCEPT she is determined NOT to be ordinary at all! Her small town is filled with mysteries and Rebekah is sure that she, along with her best friend Mouse, will be able to solve every last one of them.
Gone Girl, the latest novel from Gillian Flynn, tells a story of lies, manipulation, and revenge. The story follows Nick and Amy, a couple who are about to celebrate their fifth wedding anniversary. The pair falls on hard times when they both lose their jobs. They must move from their home in New York City to Nick's hometown of North Carthage, Missouri to live with his mother. Suddenly, on the morning of their fifth wedding anniversary, Amy mysteriously disappears.
This is extreme examination of fiction books. We take excerpts from popular novels (one page in length) from various chapters and we read them, trying to understand the writer's voice, writing structure, and more. Over time we'll have a clearer definition of how we do our analysis. This book will have notes every now and then. Enjoy! Oh, and if you were wondering, the main purpose of this is to learn how to write better fiction.
Girls Gone Raunchy is a compilation of songs by Virginia Ham, exotic dancer and Doctor of Musicology. While attending the University of Louisiana, she financed her education by headlining at Johnny's Jugs Emporium, a local gentleman's club. Virginia also did extensive research on the Uti Uti tribe in the South Pacific. Dr. Ham noted the natives would sing humorous ditties while cavorting like bunnies to the erotic beats being played by young, naked, pubescent boys.
Get ready for the next must-have on your reading list. Gone Girl meets The Girl on the Train in this stunning, unsettling psychological thriller. A baby goes missing. But does her mother want her back? When Estelle's baby daughter is taken from her cot, she doesn't report her missing. Days later, Estelle is found in a wrecked car, with a wound to her head and no memory. Estelle knows she holds the key to what happened that night - but what she doesn't know is whether she was responsible.