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It may sound premature to start thinking like a CIO this early in your career, but it will help you begin to notice things you would otherwise miss. This phenomenon is best described using a totally non-technical example. Think of a highway that you drive on all the time. It could be to and from work, to and from a loved one's house, or to and from your favorite activity.
Ok, with this vision in mind, let's pretend that one day when driving down the highway and your car is very low on gas and the "Low Gas" light starts to flash. Wanting to save money, you made the decision to buy gas at the station near your house, rather than off the highway, because you thought it would be cheaper. Then, during your drive home, you begin noticing road signs everywhere advertising gas stations just off almost every highway exit. You have driven on that highway a thousand times. Why is it that you never noticed these gasoline signs before? Well, the answer is because you didn't need gas. As a second and third example, this analogy also works for restaurants when you're hungry and restrooms for, well, you know.
Back to the topic at hand, this same phenomenon is true in the workplace. That said, if you only concentrate on your specific job, and not the other things around you, you won't notice the manager level, IT/User level, and upper management level interactions that are going on around you. These interactions include the following:
1. Interaction between IT managers: Do the IT managers work together as a team or is there in-fighting between departments? 2. Dynamic between IT managers and key business users: Are the IT managers treated as equals by the leaders of the organizations they support? 3. The relationships between IT and its vendors: Does your IT organization treat its vendors well or is it abusive, overbearing, and generally difficult to work with? 4. Employee-related philosophies: How does your IT organization treat its employees? Does it provide training? Does IT promote from within or always fill management and senior executive positions from the outside? Does IT encourage cross-department employee movement or do department managers tend to discourage movement from department to department? 5. Management-related philosophies: Are managers given decision making authority or are all decisions made by senior management? How is the IT organization organized? Are there official dotted line reporting relationships? Is IT centralized or decentralized? 6. The role of IT within the company: Is IT considered to be a strategic partner with the business groups or is it viewed as simply a service organization? Is the organization, and thus IT, an early adopter or late adopter of technology? Compared to other internal service organizations, is the IT organization well funded or poorly funded?
These types of questions can help provide you a number of insights, including the following:
• An understanding of how your manager and other senior IT executives view IT success can help you maximize your personal job performance. • Ongoing observations of how the office politics a level above you work will help you navigate those politics when you are promoted to those professional levels. • An understanding of the relationship between IT and the business community they serve can help you maximize the client service you provide and gain insights as to how IT is viewed within the company. These insights can not only help you better understand senior IT management decisions, but they can also help you decide if your current employer is somewhere you would like to be long term.
In turn, the above insights, and dozens like them, will in time broaden your perspective of the business of IT well beyond the tasks you currently perform. This widened perspective will allow you to see your department's role within IT and IT's role within the company. Senior IT executives have this wider perspective because they live it every day. It's a key component of the decisions they make. It relates to how they are treated on a day-to-day basis by their peers and senior business executives. In short, it's this widened perspective that helped propel them into the IT management roles they possess and a key factor in their ongoing survival and success within the role. For you, this widened perspective will help you succeed in your current role and assist in you in moving vertically through your organization toward the role of CIO.
If you have any questions about your career in IT, please email me at email@example.com or find me on Twitter at @EricPBloom.
Until next time, work hard, work smart, and continue to grow.
Read more of Eric Bloom's Your IT Career blog and follow the latest IT news at ITworld. Follow Eric on Twitter at @EricPBloom. For the latest IT news, analysis and how-tos, follow ITworld on Twitter and Facebook.


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ALLIANCE, Ohio -- From winning Large Business of the Year to debuting Marketplace branch, the year 2
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Eli Harold will look to make an impact in a hurry for Virginia.
Is there another Sammy Watkins out there in the ACC? Another standout, super-versatile freshman ready to take the stage on the FBS level become the talk of college football's town?
If you are looking for an offensive breakout candidate in the ACC, Stefon Diggs up in College Park could possibly fit the bill for the Terrapins. Many may make a case for Mario Edwards at Florida St., and I do believe if we were talking about a freshman for longevity's sake—the one who has the most potential—he would be at or near the the top of the list.
But Maryland is mired in, well, a mess, and Florida State has a massive amount of depth on the defensive side of the ball. We're talking impact, year one.
Who could have the greatest single impact as a freshman? I propose Virginia linebacker Eli Harold.
I remember watching film on Harold and nearly salivating at his versatility, as I am sure his coach did as well. His high school accolades include:
- ESPNU Top 150 prospect
- SuperPrep Elite 50 prospect, as well as, SuperPrep All-American and defensive player of the year
- 247Sports.com All-American
- Consensus top 50 recruit (247Sports, Rivals, Scout, ESPN)
- No. 1 player in Virginia
- No. 5 player nationally at his position
- Played in the U.S Army All-American Bowl and was selected team captain for the East squad
- SI.com honorable mention All-American
- First-team All-Tidewater
- Beach District Defensive player of the Year and first-team all-district selection at wide receiver and defensive end
A defensive player, yes, but Harold played quarterback, running back and wide receiver, accounting for 1,146 total yards and 20 touchdowns in a wildcat offense (41 receptions or 723 yards receiving).
Reading the book on Harold has to make Mike London quite the happy coach down in Charlottesville:
- 6-3, 230 pounds
- Athletic
- Long wingspan
- Burst speed and closing speed
Harold has the pure athletic ability to be able to play wide receiver—and you may see him line up on that side of the ball from time to time—but where Eli will, in my opinion, become a star is on the defensive side of the ball, especially in the UVA scheme. His combination of size, speed, wingspan and instincts will make him a force sooner than later against opposing offenses in the Atlantic Coast Conference.
Harold chose Virginia over LSU, Florida and Arkansas in order to stay home and play for the Cavaliers. He will be one to watch from the start.
Others to watch:
- Mario Edwards, DL, FSU
- Stefon Diggs, WR/ATH, Maryland
- Tracy Howard, CB, Miami
- Joel Caleb, ATH, Virginia Tech
- Eddie Goldman, DL, FSU
- Randy "Duke" Johnson, RB, Miami
- Chris Casher, DE, FSU
- Mario Pender, RB, FSU
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Human STAR Protein expressed in Escherichia coli (E. coli) - ABIN667607
Borthwick, Taylor, Bartholomew, Graham: Differential regulation of the STARD1 subfamily of START lipid trafficking proteins in human macrophages. in FEBS letters 2009
Show all 2 references for ABIN667607
The results demonstrated that ZnT7 (show SLC30A7 Proteins) gene silencing downregulated the expression of StAR, P450scc (show CYP11A1 Proteins) and 3beta-HSD (show HAL Proteins) as well as progesterone concentrations in the human chorionic gonadotrophin-stimulated Leydig tumor cells.
cAMP, SIK and CRTC mediate StAR expression through activation of individual StAR gene loci.
Bisphenol A induces oxidative stress by altering the expression of iNOS (show NOS2 Proteins), which consequently leads to the down regulation of StAR expression in the testis of male mouse
Results show that HIF1alpha (show HIF1A Proteins) appears to be a positive regulator of basal and stimulated STAR-expression, which under partial hypoxia is capable of increasing the steroidogenic capacity of granulosa cells.
The result showed significant correlation between changes in GLUT 8 (show SLC2A8 Proteins) and glucose levels with changes in StAR level in the testis and circulating testosterone level in the mice from birth to senescence
Deletion of the START domain from Arabidopsis Glabra2, a representative HD-Zip transcription factor, results in a complete loss-of-function phenotype. The mammalian START domain from StAR can functionally replace the HD-Zip-derived START domain.
These discoveries highlight the importance of mitochondrial fusion and ERK (show EPHB2 Proteins) phosphorylation in cholesterol transport by means of directing StAR to the outer mitochondrial membrane.
Data indicate that macrophages exhibited a strong time-dependent induction of mitochondrial StarD1 and plasma membrane ABCA1 (show ABCA1 Proteins), which exports cholesterol.
Data suggest that the regulation of StAR by transcription factors including SF-1 (show SF1 Proteins), GATA-4 (show GATA4 Proteins) and C/EBP-beta (show CEBPB Proteins) maybe critical mechanism involved in low-dose MBP (show MBP Proteins)-stimulated steroidogenesis.
Sodium fluoride inhibited expression of StAR and P450scc (show CYP11A1 Proteins) in mouse Leydig tumor cells, which inhibited progesterone secretion.
Immunostaining of CLOCK and PER2 (show PER2 Proteins) protein was detected in the granulosa cells of dominant antral follicles but was absent in the primordial, primary, or preantral follicles of human ovaries.Oscillating expression of the circadian gene PER2 (show PER2 Proteins) can be induced by testosterone in human granulosa cells in vitro. Expression of STAR also displayed an oscillating pattern after testosterone stimulation
activins A, B and AB down-regulate StAR expression and decrease progesterone production in human granulosa cells, likely via an ALK4 (show ACVR1B Proteins)-mediated SMAD2 (show SMAD2 Proteins)/SMAD4 (show SMAD4 Proteins)-dependent pathway.
Mutagenesis confirmed that Arg(312) and Arg(313) are crucial for this mode of regulation, and novel interactions with the START domain
StAR proteolysis is executed by at least 2 mitochondrial proteases, the matrix LON (show LONP1 Proteins) protease and the inner membrane complexes of the metalloproteases AFG3L2 (show AFG3L2 Proteins) and AFG3L2 (show AFG3L2 Proteins):SPG7/paraplegin (show SPG7 Proteins).
BMP15 (show BMP15 Proteins) down-regulates StAR expression and decreases progesterone production in human granulosa cells, likely via ALK3 (show BMPR1A Proteins)-mediated SMAD1 (show GARS Proteins)/5/8 signaling.
The novel mutation p.Trp147Arg of the steroidogenic acute regulatory protein causes classic lipoid congenital adrenal hyperplasia with adrenal insufficiency and 46,XY disorder of sex development.
Expression of StAR and P45011beta (cytochrome P450 family 11 subfamily B polypeptide 1 (show CYP11B1 Proteins)) is down-regulated in adrenocortical cells and neurons under oxidative stress by ALADIN (show AAAS Proteins) (triple A syndrome protein, human) knockdown.
deficiencies in the steroidogenic acute regulatory protein and the cholesterol side chain cleavage (show CYP11A1 Proteins) enzyme cause neonatal adrenal failure
Mutant FOXL2 (show FOXL2 Proteins) in granulosa cell tumors is able to differentially regulate the expression of many genes, including two well known FOXL2 (show FOXL2 Proteins) targets, StAR and CYP19A (show CYP19A1 Proteins).
Mutations in the CYP11A1 (show CYP11A1 Proteins) gene encoding cholesterol side-chain cleavage (show CYP11A1 Proteins) enzyme cause disordered pregnenolone synthesis, and STAR mutations do not necessarily results in typical congenital lipoid adrenal hyperplasia.
Data indicate that Ser738/742-to-glutamate (show GRIN2A Proteins) protein kinase D (show PRKD1 Proteins) mutant increased AngII-induced CREB (show CREB1 Proteins) protein and activating transcription factor 2 (show ATF2 Proteins) phosphorylation, and phospho-CREB (show CREB1 Proteins) binding to the steroidogenic acute regulatory protein promoter.
Data suggest that Escherichia coli infections (here, administration of LPS (show IRF6 Proteins)) provokes luteolysis in diestrus, non-lactating cows and down-regulation of expression of StAR in corpus luteum but has no effect on luteinization in the following cycle.
The binding of SF-1 (show NR5A1 Proteins) to the CYP17 (show CYP17A1 Proteins) and StAR promoter regions increased in theca cells incubated with low levels of luteinizing hormone.
Inhibition of the acetylation of histone H3 (show HIST3H3 Proteins) associated with the StAR promoter region by BMP-4 (show BMP4 Proteins) may be one of the inhibitory molecular mechanisms of progesterone synthesis in granulosa cells.
c-Fos/c-Jun (show JUN Proteins) complex binds to the proximal StAR promoter in glomerulosa cells, thus activating StAR gene expression and acute aldosterone biosynthesis.
The results showed that MMP-2 (show MMP2 Proteins), MMP-9 (show MMP9 Proteins), and StAR were significantly expressed in the granulosa and thecal cells of the ovarian atretic follicles during proestrus, and were strongly expressed in the corpus luteum during metestrus.
We found that adiponectin (show ADIPOQ Proteins) and insulin (show INS Proteins) alone regulate the expression of StAR, CYP11A1 (show CYP11A1 Proteins) and HSD3B1 (show HSD3B1 Proteins) genes and secretion of P4 and A4 by the porcine endometrial and myometrial tissue explants during early pregnancy and the oestrous cycle.
GATA-4 (show GATA4 Proteins) and C/EBPbeta (show CEBPB Proteins) are both required for FSH (show BRD2 Proteins) +/- IGF-I (show IGF1 Proteins) stimulation of the porcine steroidogenic acute regulatory protein gene promoter in homologous granulosa cell cultures.
EGF (show EGF Proteins) repression of FSH (show BRD2 Proteins)-stimulated StAR transcription in porcine granulosa cells is accompanied by reductions in histone H3 (show HIST3H3 Proteins) acetylation associated with the StAR gene promoter
The altered ratio of GATA4 (show GATA4 Proteins) to GATA6 (show GATA6 Proteins) after ovulation may allow GATA6 (show GATA6 Proteins) to enhance STAR mRNA accumulation.
Under hypoxia reoxygenation or ischemia and reperfusion, StAR and CYP11A1 protein and gene expression was reduced without apparent relation to TSPO changes.
Data suggest enzymes in steroidogenic pathway are induced in interrenal cells during acute/chronic stress: mc2r (melanocortin 2 receptor); StAR (steroidogenic acute regulatory protein); 3beta-hydroxysteroid dehydrogenase; steroid 11beta hydroxylase.
Results suggest that gonadotropins play a key role in the regulation of StAR, 17beta-HSD3, and P450aromA in zebrafish.
The protein encoded by this gene plays a key role in the acute regulation of steroid hormone synthesis by enhancing the conversion of cholesterol into pregnenolone. This protein permits the cleavage of cholesterol into pregnenolone by mediating the transport of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane. Mutations in this gene are a cause of congenital lipoid adrenal hyperplasia (CLAH), also called lipoid CAH. A pseudogene of this gene is located on chromosome 13.
steroidogenic acute regulator
, steroidogenic acute regulatory protein
, mitochondrial steroidogenic acute regulatory protein
, steroidogenic acute regulatory protein, mitochondrial
, START domain-containing protein 1
, luteinizing hormone-induced protein
, stARD1
, START domain containing 1
, StAR-related lipid transfer (START) domain containing 1
, cholesterol trafficker
, mitochondrial steroid acute regulatory protein
, steroid acute regulatory protein
, lipid transporter


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Fox News figures are downplaying and criticizing the latest presidential election poll -- Fox News' own poll.
The poll, released May 16, shows President Obama with a 7-percentage point lead over Mitt Romney, including a 22-percentage point lead among women. Despite the fact that the poll was conducted by their own employer, Fox News figures almost immediately began downplaying the results and criticizing the methodology. On the May 16 edition of The O'Reilly Factor, Fox News contributor Dick Morris joked that the poll showed that Fox News had "Democratic bias" because it surveyed registered voters, a group that Morris claimed include many who "are not going to vote." Morris warned, "If you want to know how the election is going to come out, don't pay attention to that."
Fox News hosts attack Fox News poll showing President Obama leading Mitt Romney by 7%
Current Status: Published/No Action (12)
Seeded on Thu May 17, 2012 11:17 AM
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As you know, DogTipper and CatTipper are online ambassadors for Amazing Pet Expos. Along with PrestonSpeaks.com, we write about the 40+ expos they host across the country and we exhibit at many of the shows, meeting dedicated pet lovers and speaking from the main stage about saving money on pet care.
One savings method we always talk about is ordering pet medications and supplies from a reputable online pet pharmacy with the VIPPS (Verified Internet Pharmacy Practice Sites) seal of accreditation. PetCareRx is an accredited online pet pharmacy with a full line of products for all your pet needs, from prescription medications to flea and tick control to food and supplements.
At our next expo, Dallas Pet Expo on June 8, we'll be doing a great PetCareRx giveaway from our booth but we also wanted to give our readers outside the expo area the chance to win, too!
One of our DogTipper and CatTipper readers will win $50 in PetCareRx points to spend as they like in the PetCareRx online store. From grooming needs to treats, heartworm preventative to vitamins, one winner will be able to enjoy a fun $50 shopping spree! Our partners over at PrestonSpeaks.com are also running a $50 PetCareRx points giveaway so you'll have twice the number of chances to win!
How to Enter
We've got lots of ways to enter in the Rafflecopter below; you can choose how many entry methods you'd like to use. This giveaway is open to US mailing addresses only. This giveaway ends at 12:01am ET on June 13, 2013. Good luck!
Disclosure: We are working with PetCareRX at our upcoming Dallas Pet Expo booth and will be sharing their site as a way to save money on your pet's needs both at the expo and on DogTipper.


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The fastest performer in our tests, with blistering 5GHz speed
The Belkin Double N+ is a beast. It measures more than a foot tall with its twin antennae extended; it boasts simultaneous dual-band 2.4GHz and 5GHz 802.11n radios; and it has four Gigabit Ethernet ports.The USB port on the rear can be used to serve music, video and photos from external storage via UPnP, and there's a BitTorrent client that can download five torrents at once and save them to the attached drive. You can also set up a hotel-style guest account, which allows you to restrict visitors to internet access, shielding network resources from view.Performance matches up with the stellar feature list. In our speed tests, the Belkin Double N+ proved the fastest of all the routers on test, with average speeds over 5GHz from router to laptop of 134Mbits/sec and 90Mbits/sec in the other direction. While reading large files, it peaked at 150Mbits/sec. Over 2.4GHz its speeds were bettered only by the single-band Buffalo WZR-HP-G300NH, and its range was superb too: it was the fastest over 5GHz at long range and the second fastest over 2.4GHz.Coupled with a reasonable price of $222, it seems hard to resist - and it passed our soak test with flying colours too. But there is a problem: although the router has a USB port that supports shared storage, the only way to access files on attached drives is to install Belkin's client software on each of your home PCs. That makes it feel like a tacked-on feature.The ability to access files directly may be added in a future firmware update, but for now it's just enough for the Double N+ to be edged out of contention by the Linksys WRT610N.
This Review appeared in the June, 2010 issue of PC & Tech Authority Magazine
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Review: TP-Link RE650
How internet routers work, and why you should keep them secure
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|You are in: Entertainment
Sunday, 30 April, 2000, 00:38 GMT 01:38 UK
Anna Ford's singing dream comes true
Anna Ford has appeared on Stars Sing the Beatles, banishing decades of regret for turning down an appearance on the Morecambe and Wise Show.
The BBC newsreader chose to sing Here There and Everywhere as her contribution to the show, which also featured former EastEnders actor Sid Owen, boy band A1 and crooner Engelbert Humperdinck.
Dressed in a cream trouser suit, Ms Ford, 56, performed the song which she has been practising in the bathroom at home.
"It's a lovely sweet, simple song, it's a love song and it suits my voice," she told the show's presenter, Jane McDonald.
"And it was Paul McCartney's favourite song - I only found that out recently," she added.
Student singer
Ms Ford, whose parents were both West End actors, told BBC One viewers she once harboured ambitions to be a professional singer.
As a student at Manchester University in the 1960s she toured the clubs with her guitar, performing folk songs and earning �5 a night.
Eventually she settled on a career in journalism but the desire to sing never quite left her.
Ms Ford revealed on Friday that she had always regretted not singing on the Morecambe and Wise show.
She told newspapers that Eric and Ernie invited her to sing in a sketch with them soon after her colleague Angela Rippon's famous dance routine on their television show in 1976.
But she turned the opportunity down fearing it would "seem derivative" after Ms Rippon's "wonderful dance".
"But I think not appearing on the show is the greatest regret of my life," she said.
See also:
27 Apr 00 | Entertainment
Epstein collection fails to impress
07 Apr 00 | Entertainment
Cilla's tribute to Lennon
01 Apr 00 | Entertainment
Beatles tell of yesterdays
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Welcome! you have reached the zac_and_vanessa community, runned by beyondordinary. This community is for people who not only like the Troy/Gabrella pairing in high school musical, but like the pairing of Zac/Vanessa in real life.
this community is filled with anything and everything of Vanessa Anne Hudgens and Zac Efron, from their latest projects and appearance including videos/pictures, to graphics (icons, banners, headers), and ANYTHING, there is really no limit, and posts are greatly encouraged.
- no haters.
- this community is members only, so make sure when you post it is members-locked or friends only.
- if you are posting icons-keep in mind that if there are more than 3 icons, the rest that exceed 3 should be placed under a lj-cut, also more than one header and banner should be placed under a lj-cut as well.
- respect others within the community.
- promote, and stay active within the community.
- any advertisement is allowed but as long as it is disney related.
-fan-fic is allowed, we would love to hear Zac/Vanessa stories. ♥
ashleymtisdale hsm_claims hsm_icons justjemma highschoolmuscl
passion_efrons tisdaleicons hsm_fics anything_efron easthighwildcat
hsm_a_rating agingmousketeer vanhudicons hsm_stills lucasfans easthigh_lims
falsexpresence popxiicons wildcat_chat babyv_stillness
comment in this entry to be affiliated.


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Departments of Microbiology and Immunology and Diagnostic and Biological Sciences
Institute for Molecular Virology
Iowa State University, Ph.D.
612-626-5525 office
612-624-0667 lab
Cell and molecular biology of HIV and HTLV; Antiviral drug target identification; Antiviral drug resistance; HIV genetic variation, evolution and population genetics; Viral quasispecies; Virus assembly; Evolution of emerging viruses; Paleovirology
The study of retroviruses over the past three decades has led to some of the most important discoveries in biomedical research, and has laid the foundation for biotechnology, cancer research, AIDS research, and human gene therapy. The discovery of reverse transcriptase helped to create the biotechnology industry, the discovery of oncogenes helped to advance our understanding of the genetic basis of cancer, and the discovery of retroviruses in higher animals led to the discovery of human retroviruses that cause cancer (HTLV-1) and AIDS (HIV-1). The creation of retroviral vectors and retrovirus helper cell lines helped to establish the field of gene therapy.
Retroviruses are relatively simple viruses that encode from three to ten genes, but are unusual in that they undergo a step in their life cycle called reverse transcription, which is the synthesis of double-stranded DNA from single-stranded RNA. We are exploring the accuracy of this process in HIV-1 replication and how it influences not only the evolution of HIV-1 variants that are resistant to anti-HIV-1 drugs, but also how it influences the development of an effective AIDS vaccine. We are also exploring how the APOBEC3 proteins impact HIV evolution and drug resistance. A long-term goal of our efforts is to define the molecular determinants for HIV-1 mutation in order to 1) manipulate HIV-1 evolution and improve the efficacy of anti-HIV-1 drugs, and 2) provide the basis for new intervention strategies.
Central steps in the retrovirus life cycle include the recognition of the genomic RNA by the Gag protein, trafficking of Gag and viral RNA to the plasma membrane, Gag oligomerization, and ultimately the biogenesis of virus particles. The details behind how Gag and RNA trafficking as well as virus particle biogenesis occurs is currently being investigated via collaboration by employing highly sophisticated biophysical approaches - including fluorescence spectroscopy methodologies that have single molecule resolution as well as cryoelectron microscopy/tomography. A long term goal of these studies is to develop a better understanding of the detailed steps of Gag oligomerization, viral RNA packaging, and virus biogenesis/virus structure. Such information will ultimately be useful for the discovery of new targets for the rational design of antiviral drugs.
Metabolic disorders associated with highly active antiretroviral therapy (HAART) are becoming increasingly important in the chronically HIV-infected population that has access to therapy. Clinical observations have revealed a strong correlation between bone density loss in HIV-infected individuals during HAART, particularly in conjunction with the antiretroviral drug tenofovir - a nucleotide analog that inhibits HIV reverse transcriptase. We are working collaboratively with bone biologists and AIDS clinicians to investigate how HIV-1 infection and tenofovir can cause bone mineral density loss.
Institute for Molecular Virology


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EU expected to fine Microsoft next week
Antitrust order flouted, say rivals and regulators
Published 10:00 pm, Thursday, July 6, 2006
Microsoft Corp. probably will be fined next week for failing to comply with an antitrust order, European Union Competition Commissioner Neelie Kroes said.
"I couldn't imagine another way," Kroes told reporters Thursday in Berlin, when asked whether EU regulators would penalize the company. She declined to say how much the fine might be.
Competitors and regulators say Microsoft, whose products run on about 95 percent of all personal computers, resisted complying with a March 2004 order to license information to rivals on how Windows communicates over a network.
The fines, which the European Commission has said would be backdated to Dec. 15, may reach hundreds of millions of dollars.
Latest business videos
Regulators from the EU's member states voted July 3 to support the commission's plan to fine Microsoft as much as $2.5 million a day for failing to comply, three people with knowledge of the closed-door meeting said at the time.
The commission, the EU's antitrust authority, says failure to provide the information hinders competition in the market.
Microsoft listed almost $4.4 billion in cash on hand and about $30.5 billion in short-term investments on its balance sheet as of March 31.
The additional fines the company may face might top $522 million as of next Wednesday, at the maximum daily rate.
Representatives of the 25-member EU will meet again Monday to decide how much to fine Microsoft, the people said. A final decision by the commission will be made Wednesday. Kroes will hold a news conference on that day, commission spokesman Jonathan Todd said by telephone.
"We believe fines to be unjustified and unnecessary," Horacio Gutierrez, Microsoft's associate general counsel, said in an e-mail to employees last week.
The penalty will come on top of the $594 million already levied on the company in the 2004 decision by Mario Monti, the competition commissioner at the time. Microsoft also was ordered to sell a cut-down version of Windows without a video and music player.
It has appealed the decision to the European Court of First Instance in Luxembourg.
Kroes said Thursday there was already a consensus to impose more fines and the decision should be taken next week.
"It's on the agenda," which usually means that "there will be a decision," she said.
Kroes said the size of the company made no difference for assessing the case.
"If people don't conform to our rules, then it needs to be corrected," she said.


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Are there any risks when you open a file that was previously saved with imperial system units and then you convert to metric system units?
What I can see is that objects get converted - so far you understand what happens.
But are there other values that are converted?
Or maybe even _not_ converted that might cause problems because they were set for an imperial world units? I am specifically thinking of render settings values that worked fine previously and might not match anymore because of the inch > cm conversion.


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Intuit YOUniversity with Sherrie Dillard: Is it true soulmate love, infatuation or a karmic completion? I will be talking intuitive love. Give me a call at 800 930 2819 with your relationship questions
02/14/2013 12:00 pm PDT
Do you ever wonder if you will find your soulmate or if your current love is your soulmate? Do you want to add some intuitive fun to your current relationship? I will be discussing the intuitive truth of love and relationships. Have a relationship question? Give me a call 800 930 2819.
Sherrie Dillard
Intuit YOUniversity Compassionate Guidance Connecting You to Your Inner Wisdom. Tune in 2nd and 4th Thursdays at Noon PT 3pm ETLifelong psychic and medium, Sherrie Dillard ...Find out more »
Sherrie Dillard
Psychic since childhood, Sherrie Dillard has been a professional psychic-medium and teacher for over twenty-five years. She has an international clientele and has given over...Find out more »


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Since 2006 students have participated in C-R Kids productions for various reasons. Some students want to study to be actors in college and become professional actors, some just to overcome shyness. Some students are looking for a place to fit in outside of school. It's a known fact that participating in theatre arts, students acquire a sense of being an important part of a team.
Everyday, our alumni are making headlines for their work on- and off-Broadway, on television, in film and behind the scenes.
To nurture, advance and create a community of young artists, fortifying their lives and those of their families, schools, communities and beyond, through the study and performance of theatre.


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INDIANAPOLIS, Ind. -- One month after a federal disaster was declared in Indiana due to severe storms and flooding, $31,675,486 in recovery grants and loans has been approved for renters, homeowners and business owners in 20 affected counties.
"Hoosiers affected by the disaster are making steady progress toward recovery," said Stephen M. DeBlasio, Sr., head of recovery operations in Indiana for the Federal Emergency Management Agency (FEMA). "We're proud FEMA has been able to assist Indiana residents in recovery efforts. Much work remains, so we're asking affected residents to help us help you. ?If you haven't yet registered for assistance, do so today. And if you have registered, be sure to keep your contact information updated with FEMA so we can deliver aid as efficiently as possible to those who qualify."
The president declared a major disaster for Indiana on Sept. 23. A total of 21,082 residents in designated counties have applied for disaster assistance, according to FEMA and the Indiana Department of Homeland Security.
$23,804,786 in Individual Assistance funds has been approved. Of this, $20,305,720 has been approved for housing assistance and $3,499,066 for assistance with other needs, such as medical expenses and damage to personal property.
Currently, 86 FEMA inspectors are verifying damage from the disaster. To date, 15,461 home inspections have been completed.
Four federal-state Disaster Recovery Centers (DRCs) are operating in affected counties. The locations are:
- LaPorte Parks and Recreation Dept., 250 Pine Lake Ave., LaPorte 46350
- Manuszczak Appliance Store, 9450 Calumet Ave., Munster 46321
- Ivy Tech Community College, 1440 East 35th Ave., Gary 46409
- Valparaiso Fire Dept. #2, 2605 Cumberland Drive, Valparaiso 46383
At the DRCs, residents can speak face-to-face with recovery experts and check on the status of applications for assistance. So far, 29,964 visits have been made to Indiana recovery centers.
In addition to FEMA assistance, low-interest disaster loans are available from the U.S. Small Business Administration (SBA) for homeowners, renters, businesses and non-profit organizations. So far, the SBA has approved $7,870,700 in loans and issued 12,078 applications for home loans and 1,710 applications for business loans.
Disaster loans can cover uncompensated losses for personal contents up to $40,000 for both homeowners and renters, and up to $200,000 for homeowners for physical damage to their primary residence. The SBA also provides low-interest loans up to $2 million for uncompensated physical losses suffered by businesses and private non-profit organizations. Businesses may also be eligible for working-capital loans. The combination of the two business loans cannot exceed $2 million.
Residents who receive an SBA disaster loan application in the mail after applying with FEMA should be sure to complete the application, even if they aren't sure they want a loan. Completing the SBA application is an important step in being considered for FEMA's Other Needs Assistance program, which covers personal property, vehicle repair or replacement, and moving and storage expenses.
The first step toward receiving disaster assistance from FEMA or the SBA is to register with FEMA.
To register, affected residents can go online at any time to www.fema.gov. Or they can call FEMA at 1-800-621-FEMA (3362), or at TTY 1-800-462-7585 for those with speech or hearing impairments. Residents can update contact information at the same numbers. Lines are ope...


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Now, Back to the Madness!April 3, 2009
We started with 65, and we're down to the Final Four. All the breathtaking games and the blowouts have culminated to the last four standing at the gates of Detroit.
The grit, hustle, practice and suspense have left us with Michigan State, Connecticut, Villanova and North Carolina. Here's the breakdown.
Michigan State vs. Connecticut - 6:07 EST, Saturday 4/4/2009, Detroit, MI
Michigan State has been a team of smoke in glass mirrors. A run to the Final Four that proves Tom Izzo's ability as a coach and motivator. This team has been through a myriad of injuries, has been counted as an afterthought and have snatched victory from the jaws of defeat multiple times.
But, after all that, here they stand with an opportunity to be crowned elite.
Then, there's Connecticut. A team that lost one of it's best players, Jerome Dyson, towards the end of the season, had to start the tournament with recruiting violation allegations circling and still managed to be here.
The match up will come down to firepower. Does Michigan State have enough fire power to handle what Connecticut is capable of doing? MSU has employed a strategy of slowing the game, playing great defense and doing just enough to win the games they've had thus far in the tournament.
That plays right into the hands of UCONN. They are the team that beats you they way you want to get beat. They can run with you, but they will play possession basketball with you and dismantle you, given the chance. I fully expect this to be a manhandling with MSU's run coming to an abrupt end. Connecticut wins 83-65 in a game with little drama.
Villanova vs. North Carolina - 8:47 EST, Saturday 4/4/2009, Detroit, MI
Villanova is a team on a mission. They started off a little slow against American, then they left no questions unanswered against UCLA and Duke. Then, they were able to prevail in their meeting with Pittsburgh, who many were counting on to win their office pool.
North Carolina was everyone's choice when the season began, but they suffered through some injuries throughout the season that made people wonder. They've gotten through those things, and they look the part of everyone's favorite, advancing to the Final Four in impressive fashion.
Now, the game. The best description I can come up with for what I expect is "Gentlemen, start your engines!" I expect this game to be an up-and-down the court shootout that keeps us all on the edge of our seats.
Although Villanova has the ability to win this game, I believe UNC will have a little too much and I expect them to play for the title on Monday after winning 94-83.
Enjoy the Final Four, and we'll discuss the final on Monday morning.


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Baltimore's Mount Vernon Place: A Jewel?
Light is all the
when it contrasts with Darkness
You might start your Mount Vernon walk by strolling along Saratoga Street, 200 block west. Your eye will immediately fall on a couple of Candle Shops: Grandpa's and nearby, Grandma's. Their windows give promise of magic-on-demand, a candle for burning to every conceivable saint for every conceivable purpose under heaven. Looks Catholic but Not. In a way, maybe. You have to cross the street to Park Ave. and Saratoga to see real Catholic: St. Alphonsus Church. In their vestibule and throughout the nave, you can also burn candles before grave if not graven images of a variety of saints. St. Alphonsus does not completely genuflect to Vatican II. One of its Sunday services is the Tridentine Mass. Years ago the church building remained open all day, what with people making novenas and downtown
|Candles and Much More!
shoppers needing to set down their
bags a minute. The church is an experience worth savoring.
|Along Park Avenue
For a young college gal coming down from Towson or Goucher, straight long hair, black tights, a couple of quotes from Sartre or Camus, and gold-tipped Sobranie cigarettes would serve as your credentials. For guys, any kind of beard would work. The hair could also be long. The jazz combo was more than passable. The beat generation bar closed even before the 60's were out. Morris Martick later reopened the place as a French restaurant. I have a friend who dined there in recent years. She and her small group were the only customers. An eternity of time passed, after which the octogenarian owner produced the meals and then remained at the table to talk. After closing the beat joint, Mr. Martick actually traveled to Paris and learned French cuisine. Some say he wanted to get away from the Martick's customers.
|A lonely-looking Marticks
The Central Enoch Pratt Free Library on Cathedral Street was a wonderful world in itself before the Archbishop's soup kitchen directly across the street filled the library seats with hollow faced men who sometimes stared, sometimes snored, people who had so many needs including lifebuoy. These poor souls did not seem dangerous but some readers were intimidated. The library often shows films. One Sunday afternoon the film was about the Nazi Holocaust. The audience was a 50-50 mix: half soup-
kitchen patrons whiling away the hours before supper; the other half attendees who had traveled to downtown Baltimore because of special interest in the subject of the film. All attendees were well-behaved, but the street people tended to chortle at the wrong times in the documentary; e.g. a Nazi bragging about lampshades, soap, someone's uncle....the others perceived no humor in this somber viewing. Recently the soup kitchen, Our Father's Place, has found a new home three blocks east, almost under the JFX at Madison Street, near the city jail. The hungry and the homeless are now largely removed from one's sight. Hunger and homelessness of course remain.
In our wanderings around Mount Vernon, we are searching for the arcane, at the Theosophical Society in Maryland, which occupies the 2nd floor of 523 N. Charles, is as arcane as one can get. Every Friday at 8 p.m. attendees sit around a round séance-type table in a room lifted from Victorian England. The subjects run the gamut from The Secret Doctrine by Blavatsky (founded TS in 1851) to Buddhism to Giordano Bruno. I've heard it said that every crank and eccentric in the city has cycled through 523 at one time or another. Since I am in that category, how could I tell? (I'm using "crank" here in the British sense: not cranky, rather someone who might seize hold of an "overvalued idea" and make a career of espousing it.). Directly across the street at 518 N. Charles is an entertainment establishment and restaurant whose current name alludes me. When it was in its prime, it was a bookstore called Louie's. There was dining in the back and upstairs. After the gargantuan bookstores like Border's and Barnes/Noble hit the area, the book component could not compete.
I have no dark tale to attach
to Louie's, but being Baltimore, stuff happens. Keri, a lovely young woman
who worked at Louie's became the victim of a grisly murder. The murder did
not occur at the bookstore but the victim with her striking good looks and
long red hair might have first been noticed there. The killer was never
|The Monument St. homes are very stately. The Engineers' Club, the stunning Methodist church with its dramatic steeples, and Peabody Institute are all here. The Walters Art Gallery backs into the 600 block N. Charles. The Washington Monument intersects Mt. Vernon Place.
|A deserted Alley
|Mt. Vernon Square
The tall George Washington Monument intersects the four squares. At Christmas time, the monument is decorated and lighted, always a big news event. The politicians emerge from City Hall to be seen, whereas the hordes of bystanders merely come to see. Many decades ago a man got bopped over his head (fatal) for taking too long at a drinking fountain in the eastern stretch of the park.
The Baltimore Flower Mart has been able to reincarnate itself, and once more uses Mount Vernon for its annual May festival. .A peppermint stick in a half-lemon used to be the marquee food event. The festival is enjoyed by all. Such was not always the case. In the late l960's the smaller, much more sedate Flower Mart was interrupted by gangs of marauding teenagers. A hasty change of venue was called for.
In the warm months, a variety
of events are held at Mount Vernon Place including the annual Book Fair and
concerts. First Thursdays also bring happy crowds to the streets;
museums and shops stay open late. In July a much larger whole weekend event,
Artscape, is held in the neighborhood of Mount Royal, just north of Mount
Vernon. It's usually as hot as Hades at Artscape, but the crowd keeps its
cool. These kinds of activities show the city at its best.
4 separate locks on her back door. One day this meager lodging was ransacked, locks and all. The hinges were lifted. The crooks couldn't have picked a slimmer bone. Enid didn't even own a TV! They left their DNA in the form of feces everywhere but the toilet. A sympathetic policeman explained that such residue is not uncommon at robbery sites because the thieves can be literally scared shitless. Nothing personal....The Stafford hotel on Charles Street has also seen better days. One man of my acquaintance, one of the Theosophists, resided there for years. He was found dead in his room, a probable suicide. I'm sure his was not the only body carried out of the Stafford feet-first.
|Stafford Hotel. 700 block Charles St.
Perhaps it is time to leave the glitter of the Charles Street lights and restaurants and take a break, amble two blocks west on Monument Street, to Park Ave. You are at Grace and St. Peter's Episcopal Church. Masses are offered at least daily. The incense can be so strong as to set off the smoke alarm. This truly has happened. Fire engines are automatically dispatched. A statue of King Charles I of England, the one who got beheaded, stands at the back of the nave. Candles can be lit. Charles 1 is considered an Anglo-Catholic martyr. Seriously, Solemn High Mass at l0 a.m. Sundays is good value for one's time. Some people consider Episcopalians "Catholic Lite." At G.A.S.P. it is "Catholic Heavy." You get Stations of the Cross in Lent, Benediction with the monstrance, Hail Marys, the works!
Charles I Statue
in Gasp
|Stained Glass Window -Gasp
The 800 block Park Avenue and nearby streets were once known as the Meat Rack, though I have never known an abattoir to be in the vicinity. There have long been a number of gay men and gay bars here, however. The grandfather of them all is Leon's. It has stood at 870 Park Avenue forever! The Hippo at 1 W. Eager is the city's oldest gay disco. Shortly after its 2 a.m. closing time, especially on a weekend, the unit block of W. Eager will be swarming with men. This is decision time: do you want to take someone home with you? Other gay restaurant/bars in the vicinity are Mount Vernon Stable in the 900 block N. Charles and Grand Central Station in the 1000 block. This list is far from all-inclusive. GLCCB, The Gay, Lesbian (and bisexual and transgender) Community Center of Baltimore, 200 block W. Chase Street, is a book store and information hub. It hosts dozens of meetings for the diverse groups in its community: e.g. women, older men, transgender persons. It holds fun activities as well as support groups. It assists with medical problems. ((You have probably noticed, and this is not gay-specific, -- no one actually has problems anymore. Instead, they have issues. "He had kidney issues and needed a kidney transplant. " ))
A few Remembrances of Restaurants Past: Uncle Charlie's was trendy in the 1970's. You entered on Madison Street, descending a couple of steps. For a couple of diners, those steps were like crossing the River Styx. At least 2 patrons left by ambulance. In all fairness, one of these was an older lady whose evenings out often ended at the closest E.R. A pal of mine once deposited a pool of sick as we exited to the curses of a waitress. Once outside, a passerby reached for the gagging woman's pocketbook. I grabbed her and the pocketbook as we jumped into a conveniently cruising taxi. These experiences were exceptions. The upscale crowd filled up the place as they talked about the play they had attended at Center Stage. I do not know what precipitated Uncle Charlie's closing....The passing of the Mount Vernon Restaurant, its intimate, dark wooden booths beyond the bar, is mourned to this day. It was one of those restaurants you might go to when you really did not feel like dressing up and spending a lot of money to go to a restaurant.....The Harvey House, at 920 N. Charles Street, was also a Baltimore institution. At the front was a piano bar where patrons gathered to sing. Somewhere in the 1990's Harvey House became Mughal Gardens. For more on Harvey House, please read about the woman who failed to attend her own party: http://www.baltimoretimeline.com/murders.htm. You will find no traces of the Peabody Book Shop and Beer Stube, once at 913 N. Charles St. A place like this should never have been torn down. New generations of young persons would have discovered and embraced it just like my mother's generation did, so long ago. (DRB)


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Naked Tourist Causes Ruckus At W Hotel In Ft. Lauderdale
A Texas man is accused of causing a ruckus in Fort Lauderdale that would make Charlie Sheen blush.
Cops arresting 33-year-old Austin Ragans after they say he tossed a chair and beer bottles from the 16th floor of the W Hotel...
The chair actually hit a hotel employee on the ground...but he's expected to be ok.
When police got inside, they found Ragan completely naked, with a bag of cocaine.
He's now facing several felony charges.


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[Back | Archive]
Story ran on April 1, 1999
Stewart became mentor to many
Coach, players have fond farewells.
By KENT HEITHOLT
Tribune Sports Editor
Even one of his bitterest foes was stunned and saddened by Norm Stewart's decision to step down as basketball coach at Missouri today.
Floyd Irons, the longtime head coach at Vashon High in St. Louis, has had more than a few disagreements with Stewart over the years. Today, he said there is no satisfaction in seeing the MU coach end his career.
"I hate to see it when an icon is forced out regardless how anybody feels about him," Irons said. "Norm and I were not the best of buddies over the years, but I respect what he's done. He did amazing things and he did it his way."
Former Kansas coach Ted Owens, now a vice president for Rebound Sports in Tampa, Fla., was one of Stewart's biggest rivals. Owens was the head man of the established team in the Big Eight when Stewart started to build a giant at MU.
"Even tough Kansas and Missouri have been rivals since the Civil War, you still build up a respect for someone who did what he did," Owens said. "He came in when their programs was not so good and built it into something. I have an admiration for what he did."
That's not to say Owens wasn't irked a time or two by Stewart.
"Of course," Owens said, "but he never bothered me as much as the Antlers."
Stewart built the program by landing some in-state recruits and lessening the talent pool for teams like Kansas, Kansas State and Oklahoma State. John Brown, an all-American at MU, was one of the first big-time recruits for the Tigers. With the addition of Al Eberhard, the Tigers became a force.
"He did more for us than just basketball, he taught us so much about life," Eberhard said. "I just know he's going to enjoy his retirement because he deserves it."
Eberhard suspects that Stewart's desire to keep Missouri competitive led to his decision.
"He had such an intense loyalty to the university and the state of Missouri, he never wanted to leave them without any players," Eberhard said.
Hickman coach Jim Sutherland, whose son Jason was one the Tigers' stars in recent seasons, said while Stewart's legacy is huge there were tensions for players. Sutherland said his son's rough and tumble reputation around the Big Eight was the result from being asked to serve in that role for the team.
"Jason gained a lot from being at Missouri. In fact he signed with Missouri because of Norm Stewart," Sutherland said. "He was the kind of kid who would do whatever they asked.
"There's no doubt, it was tough on the kids to play at MU. But they got a lot out of it."
John Burns, a former Tiger captain who coaches high school basketball at Kearney, learned of Stewart's retirement on ESPN.
"I was shocked at first because I never expected it to happen this way," Burns said. "He was a very influential part of my life. He used to tell that what happens to you isn't as important as how you react to it."
Today, everyone reacted in their own way.
Send questions or comments to: firstname.lastname@example.com


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Madison Scholarly News—May 2010
Dr. M. Joseph Hinshaw (Associate Professor, Media Arts and Design) and Michael Grundmann (Assistant Professor, Media Arts and Design) have won four national awards for "Geometry Rules," a 15-minute educational video that illustrates the uses of geometry in the workplace and in games and sports. Designed for middle-school students, the video won the Best of Competition (faculty videos, educational/instructional) in the Broadcast Education Association's Festival of Media Arts, a Telly bronze award, an Aegis Award and an Award of Excellence from the Videographers Awards.
Dr. M. Joseph Hinshaw (Associate Professor, Media Arts and Design) and Ron Osgood of Indiana University won an Award of Excellence from the Videographer Awards in the interactive/DVD category for the DVD that accompanies their textbook, "Visual Storytelling: Videography and Post Production in the Digital Age."
Dietrich Maune (Associate Dean, College of Arts and Letters; Professor, Media Arts and Design) exhibited two paintings, "I Remember South Dakota" and "Sheep, Cape St. Mary's," in the exhibit "The Paul Hartley Legacy" at the Lee Hansley Gallery in Raleigh, N.C., in January and February and at the Greenville Museum of Art in North Carolina in March and April. Maune is one of about 100 of Hartley's former students selected by a committee for the exhibition honoring his late mentor. Maune's painting, "The Red House, Monhegan Island," was selected and purchased by The Ambiance Group, a fine art consulting firm in Nashville, for the permanent collection of the new Rockingham Memorial Hospital.
Dr. Daniel M. Downey (Professor, Chemistry) received $10,000 from the U.S. Department of Agriculture Forest Service to continue inventorying water quality of forest streams and monitor the effects on stream water chemistry.
Dr. Clarence R. Geier (Professor, Anthropology) received $110,000 from Carmeuse Lime & Stone to conduct a Phase I historical archaeological program that will result in the location, description and preliminary assessment of those prehistoric and historic sites lying within the project area.
Dr. Clarence R. Geier (Professor, Anthropology) and Dr. Anna M. Courtier (Assistant Professor, Geology and Environmental Science) received $1,083 from the Shenandoah Valley Battlefields Foundation to review historic and archaeological data that will be used to provide a context for the interpretation of prehistoric and historic cultural remains identified on the Ramseur's Hill Parcel.
Kimberlee Hartzler-Weakley (Administrator, Institute for Innovation in Health and Human Services) received $7,286 from the Office on Children and Youth to support the Teen Pregnancy Prevention Program.
Chelsea L. Jenkins (Executive Director, Virginia Clean Cities) received $710,000 from the Environmental Protection Agency to improve air quality through the replacement of school buses and construction equipment engines and to increase the efficiency of school buses through combining idle reduction technology and low rolling resistance tires.
Dr. Anthony L. Tongen (Associate Professor, Mathematics), Dr. Laura A. Taalman (Associate Professor, Mathematics) and Dr. Paul G. Warne (Associate Professor, Mathematics) received $27,499 from the Mathematical Association of America to continue the M3 summer program to foster mathematical development and personal mentorship.
Dr. Kerry Dobransky (Assistant Professor, Sociology and Anthropology) received the American Sociological Association's 2010 Roberta G. Simmons Outstanding Dissertation in Medical Sociology Award.
Dr. Steven D. Anderson (Director and Professor, Media Arts and Design) presented on two panels, "Developing Websites with Content Management Systems: Helping Students Help Clients" and "Collaboration and Learning via Social Media in Study Abroad," at the Broadcast Education Association Convention in Las Vegas in April.
Rustin P. Greene (Professor, Media Arts and Design) presented on two panels, "You Can't Shoot a Dream, You Can Only Shoot a Story: A Producer's View of Documentary Scripts" and "The Photoboard: Storyboarding Without a Pencil," at the 2010 Broadcast Education Association Convention in April.
Dr. John E. Guiniven (Associate Professor, Media Arts and Design) presented "The Effectiveness and Ethics of Cause-Marketing: A Front-Burner Issue" at the International Public Relations Research Conference in Miami in April. Guiniven presented "Accessorize for America: The Role of PR in Creating the Consumer Nations and the Ethical Implications Going Forward" to the Public Relations Council of the Shenandoah Valley, Oct. 27, 2009.
Thomas J. McHardy (Associate Professor, Media Arts and Design) presented "Teaching on the Road: Film Studies in a Summer Abroad Program" at the 2009 University Film and Video Association Conference in New Orleans. McHardy also exhibited an interactive guide to the Z1U camera, a tutorial he is developing for one of his courses.
Thomas O. O'Connor (Associate Professor, Media Arts and Design) presented "Graham Greene: Culture and Contradiction" at the International Conference on the Arts in Society in Venice, Italy, in July 2009.
Dr. David H. Wendelken (Associate Professor, Media Arts and Design) led a panel on "Blogging as a Classroom Teaching Tool" at the National Convention of the College Media Advisers in New York City.
Dr. Dolores L. Flamiano (Associate Professor, Media Arts and Design) wrote an article, "Heroes of Hell Hole Swamp," which was published in Southern Cultures, an interdisciplinary journal published by the Center for the Study of the American South at the University of North Carolina at Chapel Hill. Flamiano also wrote "Japanese American Internment in Popular Magazines: Race, Citizenship and Gender in World War II Photojournalism" for Journalism History.
Rustin P. Greene (Professor, Media Arts and Design) wrote an article, "Can Student Screenwriters Provide Valuable Criticism to Their Peers? Yes…Maybe," which was published in the Journal of Media Education, January 2010. Greene also produced "JMU's Semester in Florence: Living The Dream," a promotional video for JMU's Office of International Programs.
Dr. John E. Guiniven (Associate Professor, Media Arts and Design) wrote an article, "Good, Bad – and Does it Matter? An American Professor Evaluates Ukraine's Image in the U.S.A.," which was published in Willard Marketing Monthly, Kyiv, Ukraine, September 2009. Guiniven also wrote "Supreme Court Expansion of First Amendment Freedoms is No Gift to PR Practitioners," which was published in The Public Relations Strategist, Spring 2010.
Dr. Alexander S. Leidholdt (Professor, Media Arts and Design) wrote "Never Thot This Could Happen in the South!" for the Appalachian Journal.
Thomas O. O'Connor (Associate Professor, Media Arts and Design) wrote an article, "Culture and Contradiction in Graham Greene," which was published in the International Journal of Arts in Society, Vol. 4, 2009.
Dr. J. Peter Pham (Associate Professor, Justice Studies, Political Science and Africana Studies) contributed an essay, "The Somali Solution to the Somali Crisis," in the annual volume of the Harvard Africa Policy Journal.
Dr. J. Barkley Rosser Jr. (Professor, Economics; Kirby L. Cramer Jr. Professor of Business Administration) published a book, "European Economics at the Crossroads," coauthored with Richard P.F. Holt and David Colander. The book was published by Edward Elgar Publishing: Cheltenham, United Kingdom, and Northampton, Mass., and was simultaneously released in hardback and paperback.
Dr. David H. Wendelken (Associate Professor, Media Arts and Design) had one of the images from his photo blog on birds and butterflies selected for inclusion in Cornell University's encyclopedia, "Birds of North America Online," and another featured in an exhibition at the visitor's center at the Cornell Lab of Ornithology and at some National Wildlife Refuges.
Dr. Steven N. Whitmeyer (Assistant Professor, Geology and Environmental Science) and Jeremy Nicoletti (student) wrote an article, "The digital revolution in geologic mapping," for the GSA Today, a publication of the Geological Society of America. The article appeared in the April/May 2010 issue.


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Jon Voight, the father of actress Angelina Jolie, speaks out on the rumors that his actress daughter may be pregnant with twins.
While rumors on Angelina Jolie's pregnancy keep circulating among people and there has yet any official statement from the actress herself, her actor father Jon Voight spills the bean on that matter.
Spoke out on the persistent pregnancy rumors, Voight said he's excited by the prospects that Jolie might be pregnant. "It's wonderful news that she's having another child, if that's true," The New York Observer quoted Voight on Monday, January 28 as saying.
"I can't count on anything the press says about her because there is so much said but she has certainly captured the imagination of the press," added Voight.
Rumors that Jolie might be expecting twins arose hot on the heels of speculation that she and her actor partner Brad Pitt planned to adopt another daughter from Africa in addition to their three adopted children; Maddox, Pax, Zahara, and their biological daughter Shiloh.
Jolie added fuel to the pregnancy rumors after she wore a loose and flowy vintage Hermes dress to Sunday night's SAG Awards. Pitt's representative however refused to comment on the pregnancy rumors.


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I think it all depends upon how long you want to keep the car. IIRC per the discussion 2 years ago when I was researching this: The GP Thunders are basically the Halogen bulbs that for lack of a better description have been painted blue to give them the blue-white color. After a time the paint burns off and you are left more or less, with the original intensity and color of the OEM Halogen. If the GP Thunders are $30 USD per bulb you can buy roughly 4 sets for the price of one set of LUX H8s. The question then becomes how much do you like to play with these things. My set of LUX LED bulbs is closing in on 2 years old and look as good today as the day I installed them. They don't flicker and they don't fault.
IMHO, the only aftermarket solution better than LUX is to pull the headlight units and send them to OSS in Florida for a $$$$$$ solution.
If your sport doesn't put blood, dirt or grease under your fingernails,
then it's just a game.
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Lash Act Mascara from Meet Mark
Written by msmakeup1829, Posted in Blog
Price: $12
Where to Buy: Meetmark.com or your AVON Rep
Pros: Concept & Formula
Cons: Can Dry/Flake up
Packaging: Standard Mascara Tube. What makes this mascara stand out, is that the wand is what gives you length or volume with a twist of the top. It comes it 2 colors. Black, Purple and Brown/Black. Brown/Black is in Photo.
Review: If you have wanted to try the mascaras out there has a dual wand this might be the one to try. With the twist of the wand you can get length or volume. I love this concept because it is like having 2 mascaras in 1. It is such a time saver. The formula is really easy to work it. It builds nicely and does to leave lash looking clumped up. I am a sucker for concepts like this. I have average lashes, not to thick and an ok length. But just like everywhere out there you always want to have thicker fuller lashes. I did not however that as time went one while I wear it, it because dry and even flaked a little. Not very much but is enough that noticed.
Overall: I think if you are looking for an inexpensive version of the other mascaras out there that claim to give you length and volume but the twist of the wand, I think this should be in the running. I feel that it did want it says it does. Which is good. Try it for your self, maybe you have found your "Holy Grail" mascara.
Name Melissa E.
Twitter: msmakeup1829
Blog: http://confessionofamakeupjunkie.blogspot.com/
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Instagram: msmakeup1829


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In her book, ``Passages,`` Nancy Friday describes the often-drastic career changes men around age 35 make when they are ``tired of accommodating others`` and want to satisfy their own needs. A case in point is Evanston baker Norbert Seufert.
Seufert grew up on Chicago`s North Side, where his family lived behind his father`s bakery. There he spent many of his childhood hours doing what he loved most: baking. But when it came to choosing a career, he listened to his parents. They thought teaching would be an easier and more prestigious occupation. So after graduation from Drake University in Iowa, Seufert earned a master`s degree in education from DePaul University, then spent 12 years as a Chicago elementary school teacher.


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Marriage Counselor
David Palmiter, Ph.D., ABPP
Clinical Psychcologist
304 Royal Oaks Drive, Clarks Summit, Pennsylvania
Most of our marriages and relationships are like orchids: if treated like a cactus–because there are so many other very important things to do–they wilt and die. But, if their care is prioritized, and well executed, they become a centerpiece of beauty in our lives.
Marriage Counselor
John Kuna, Psy.D.
Licensed Psychologist
327 North Washington Street Suite 104, Scranton, Pennsylvania
Our Family and Marital therapists work with families both together and individually to help them improve their communication skills, heal mutual wounds, and generate positive aspects of the relationships.
Marriage Counselor
Harlene Arenberg, MS, LPC
6 Pen Y Bryn Drive, Scranton, Pennsylvania
Harlene is deeply passionate about helping couples and families achieve their goals and realize their greatest potential. She listens intently and offers insight, knowledge, and proven tools to assist in their quest for personal growth and transformation.
Marriage Counselor
David Gallick, MSW, LSW, LMFT
Licensed Marriage and Family Therapist
480 Pierce Street, Suite 300, Kingston, Pennsylvania
As a "Licensed" Marriage and Family Therapist, I have done extensive work with couples, families, individuals, children, and adolescents. I have extensive training in Marriage, Family, and Sex Therapy providing professional, confidential services for more than 25 years
18843 is a zip code located in Susquehanna County and part of South Montrose, Pennsylvania. It has a land area of 0.877 square miles.  The population of 18843 is 277 people.


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Intelligence contractor turned whistleblower Edward Snowden has applied for asylum in a number of countries, including Germany. In a statement, he also accused the US government of "using citizenship as a weapon."
The WikiLeaks website published a statement purportedly from Edward Snowden and information on a string of asylum requests that the former intelligence official has filed with countries around the world.
According to WikiLeaks, Snowden on Sunday formally applied for asylum in India, Brazil, Germany, France, Italy, Bolivia, Venezuela, China, Nicaragua, Cuba, Switzerland, Poland, Norway, Spain, Ireland, the Netherlands and Austria.
The 30-year-old former contractor for the National Security Agency (NSA) also applied for asylum in Russia, where he is currently believed to be situated. President Vladimir Putin said on Monday that he would agree to Snowden's request, on the condition that he stopped leaking US secrets.
Snowden is believed to have spent the past week in a transit area at a Moscow airport; without divulging his whereabouts, Snowden complained in a statement posted by WikiLeaks that he was stateless and trapped. Snowden had stayed silent since his arrival in Russia from Hong Kong.
US hindering asylum hunt?
"The Obama administration has now adopted the strategy of using citizenship as a weapon," the statement, signed Edward Joseph Snowden, said. "Although I am convicted of nothing, it has unilaterally revoked my passport, leaving me a stateless person."
Snowden accused Washington of seeking to stop him from applying for political asylum, a right enshrined in Article 14 of the UN's Universal Declaration of Human Rights. He said that it was being reported that, "after promising not to do so, the President ordered his Vice President to pressure the leaders of nations from which I have requested protection to deny my asylum petitions."
Ecuador's President Raffael Correa said US Vice President Joe Biden raised the issue with him in a weekend phone call. Snowden said Obama was guilty of "deception" and imposing "the extralegal penalty of exile," calling such methods "the old, bad tools of political aggression."
After revealing data on a program known as PRISM that allegedly allowed the NSA and other authorities to access information on users of some of the world's largest online platforms, Snowden is wanted on espionage charges in the US.
He said he had left Hong Kong last week "after it became clear that my freedom and safety were under threat."
'Not me, but those who would come after me'
The fugitive said in his statement that the US response was designed not to frighten him, but rather future whistleblowers considering the same path.
"In the end the Obama administration is not afraid of whistleblowers like me, Bradley Manning or Thomas Drake," Snowden said. "We are stateless, imprisoned, or powerless. No, the Obama administration is afraid of you. It is afraid of an informed, angry public demanding the constitutional government it was promised – and it should be."
Germany's prominent Green party politician Jürgen Trittin on Monday said in an ARD public television interview that he thought Germany should offer asylum to Snowden.
msh/ch (AFP, dpa, Reuters)


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- Athletics Home
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Georgetown College's men's and women's track and field continued to show signs of improvement after being back in competition only a few seasons. Both finished seventh in this past weekend's Mid-South Conference meet at University of Rio Grande, setting several records along the way.
The men's Keith Arutoff broke teammate's, roommate's and friend's school and conference record in the hammer. Nick Kelly's throw of 35.21 meters in the 2010 meet stood for over a year, a year and five days to be exact.
Arutoff set the new mark at 38.55 to take the competition and also earn all-conference honors. Kelly did not compete this year, but with both back for the Tigers and coach Todd McDaniel things could be really exciting for track and field in 2012.
Arutoff also finished fourth in the discus throw with a school record throw of 41.45 meters.
John Michael Mayo's javelin throw of 51.85 meters notched another conference event win and all-conference honors. He currently holds the GC record with a throw of 58.53 set in 2009.
The men's team finished seventh with 74 points. Along with solid showings in several field events, distance runner Grant Curren helped the team with a third place finish in the 800-meter run. Mark Scout finished sixth in the 110-meter hurdles for three points and eighth in the 400-meter hurdles for one point. Corey Hatfield's fifth place finish in the 3000-meter steeplechase picked up points for GC. Tyler Doolittle, LeRon Collier, Cody Polzin and Brennan Carrithers comprised the fourth-place 4x400-meter relay team, while Curren, Grant, Polzin and Brandon Pulliam took fifth in the 4x800-meter relay.
Hatfield 1.73-meters in the high jump to finish eighth and Zachary Virgin's 3.51-meter mark was good for third in pole vault. Dillon Meyers finished eighth in the long jump and Bill Beckerson fifth in the triple jump for more Georgetown points. Mark Scout finished fifth in the decathlon, while Reid Stivers' eighth-place finish in the 5,000-meter walk race rounded out the scoring for the male Tigers.
The women finished seventh as well with 51 points.
Danielle Buford's 13.31 in the 100-meter dash was fifth and put GC on the board with four points. Her seventh-place finish in the 200-meter dash picked up another two points. Elisha Overpeck finished fifth in the 1,500-meter run and fourth in the 5,000-meter run.
Finnja Ramcke took eighth in the 100-meter hurdles and sixth in the 400-meter hurdles. The sophomore rounded her individual day with a fourth in the 3,000-meter steeplechase, breaking her own school record set earlier in the season in a time of 12:55.95.
The 4x100-meter relay team of Caroline Hutson, Emily Buerger, Jasmine Strunk and Buford ran a 52.46, a seventh-place finish. While the 4x800-meter team of Overpeck, Ramcke, Emily Steck and Caitlyn Anglin finished sixth.
Amanda Williamson's second place finish in the high jump was the women's team's best finish all day, and she was just shy of her own school record - clearing 1.51 and the record is 1.52. Anglin cleared 1.47 for a fifth-place finish in the high jump.
Hutson took fourth in the triple jump and rounding out the field events was Caitlyn Kogge's throw of 26.88 in the javelin for fourth place.


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Northwestern Oklahoma State University will observe the traditional collegiate spring break from March 18-22. Classes will resume their normal schedule on Monday, March 25.
Administrative offices at all three campuses will be closed Monday through Wednesday, March 18-20. Offices will be open Thursday, March 21, and Friday, March 22, with regular office hours.
As a reminder to individuals who are interested in attending Northwestern in the summer or fall, enrollment currently is open for the summer session, and enrollment for the fall session will open March 26. Fall semester classes begin Aug. 19. Summer classes begin June 3, with interim classes on May 14-31.
To see what classes are available, visit www.nwosu.edu/course-schedules.
To enroll for any semester at Northwestern, all first-time freshmen and transfer students first must be admitted to the university, then obtain a class schedule and enrollment form, complete the form with an adviser and obtain the adviser's signature prior to completing the enrollment process. The enrollment process must be completed in the registrar's office.
Each first-year freshman must enroll in one of the Ranger Connection classes. This class is designed to help students connect to and learn more about the university. Ranger Connection classes are listed under University Studies in the spring schedule.
Current students also must enroll through the registrar's office except for those pre-approved by their advisers to enroll online.
Students admitted to the Graduate School may enroll in person or online using the RangerNet system on the Northwestern web site. Students enrolling in graduate courses for the first time at Northwestern must enroll in person.
Students with enrollment questions may call the Alva Registry Office at (580) 327-8551, the Enid Registration Office at (580) 237-0334 or the main office in Woodward at (580) 256-0047.
MISSION STATEMENT: Northwestern Oklahoma State University provides quality educational and cultural opportunities to learners with diverse needs by cultivating ethical leadership and service, critical thinking and fiscal responsibility.


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Kazmir pitched five impressive innings for the win and Jose Cruz Jr. hit a three-run homer to lead the Tampa Bay Devil Rays past the Seattle Mariners 9-0 Monday night. (Related item: Box score)
"Man, this is a dream come true, it really is," Kazmir said with a grin after being drenched with champagne by his teammates in the clubhouse. "I was really nervous. I was looking at the crowd and everything."
The Devil Rays ended a six-game road losing streak and won for only the second time in their last 17 away from home.
Kazmir was acquired July 30 in a trade that sent right-hander Victor Zambrano to the New York Mets. Considered one of the top pitching prospects in baseball, the 20-year-old left-hander gave up four hits, walked three and struck out four.
Kazmir (1-0) was called up earlier in the day from Double-A Montgomery to join the Devil Rays' rotation for the final six weeks of the season. Manager Lou Piniella said Kazmir was being given an audition for a spot in the 2005 rotation.
The 6-foot, 170-pound Kazmir's fastball reached 96 mph on the Safeco Field radar gun. He was lifted after throwing 101 pitches, 56 for strikes.
Kazmir's first batter was speedy All-Star Ichiro Suzuki, who leads the AL with a .369 average. He grounded out to shortstop on a 1-2 pitch.
"I kind of settled in and felt a little bit more comfortable, especially when I got Ichiro out," Kazmir said. "That took a load off me. I didn't even make eye contact with him. I just imagined that he wasn't even there."
Piniella didn't have much to say to Kazmir before the game. His second start will come Sunday in Oakland.
"What we wanted from him more than anything else was command of the strike zone," Piniella said. "I think for a young pitcher, you overload the circuit. So just get the ball over the plate with good stuff and let that take care of itself."
Piniella, 60, can't get over how young the fresh-faced Kazmir looks.
"Some of our players didn't recognize that he was the young man who was joining our team on the airplane coming here. So imagine if he looks young to the players, how young he looks to me," Piniella said.
Travis Harper and Lance Carter each pitched two innings of scoreless relief to finish the five-hitter, Tampa Bay's fifth shutout of the year. The Mariners were blanked for the ninth time.
Suzuki went 1-for-4 with a single, his 198th hit of the season, most in the majors.
Cruz, in his first season with Tampa Bay after playing in San Francisco last season, capped a four-run sixth with his 18th homer of the season off Bobby Madritsch (3-1).
With one out, Julio Lugo walked and B.J. Upton singled him to third before Tino Martinez blooped a single into left to score Lugo from third and send Upton to second.
Cruz then hit the first pitch from Madritsch off the left-field foul pole. It was his 10th career homer against Seattle, his first major league team. The Mariners shipped him to Toronto at the 1997 trade deadline.
"It's good to come back to Seattle, where everything started for me and a lot of things are familiar to you," Cruz said. "For me, there are still some guys I know on the other side."
The Devil Rays sent nine batters to the plate in the eighth against Clint Nageotte and scored five more runs. Cruz had a run-scoring single for his fourth RBI. Toby Hall added a sacrifice fly, Geoff Blum had an RBI single and Rey Sanchez doubled in the final two runs.
Madritsch, making his fourth start and second against Tampa Bay since being called up from Triple-A Tacoma on July 21, pitched seven innings and allowed four runs on five hits and two walks, with six strikeouts.
"Bobby really pitched well," Mariners manager Bob Melvin said. "The one ball that was hit really good was pretty timely. It looked like it was going to hook foul, but it stopped hooking and hit the foul pole."
Piniella improved his record to 12-11 against the Mariners, the team he managed for 10 seasons before asking out of his contract to return to his hometown after the 2002 season.
Notes: Mariners closer Eddie Guardado is scheduled to have arthroscopic surgery on his left knee Tuesday to repair a torn meniscus. The operation will be performed in Los Angeles by Dr. Lewis Yocum, team physician of the Anaheim Angels. Guardado, 33, was placed on the 15-day disabled list Aug. 1 with a tired left shoulder. ... Edgar Martinez of the Mariners hit his 511th double, tying him with Mark Grace for 33rd on the career list.


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A TODDLER at a Bromsgrove class has managed to raise hundreds of pounds for a children's charity.
Fin Carpenter, from Halesowen, attends the Toddler Sense classes in the town.
The classes recently participated in Tommy's Sensathon - a cowboy themed fundraiser.
At the event the two-year-old and other toddlers were sponsored by parents and family members to have some wild West fun, enjoying a host of fun activities and dressing up in cowboy clothes.
Fin managed to raise an impressive £250, which was boosted even more by his father, Darren's employers, the Pertemps People Development Group which donated an extra £150 to take the total up to £400.
The money raised is being donated to the Tommy's charity, which funds research into stillbirth, premature birth and miscarriage.
Darren said he is extremely proud of his loving and kind-hearted son.
"Like all children, Fin is very precious so helping raise money for Tommy's was important to the whole family," he said.
"I was particularly delighted when my company provided the extra contribution as part of its community support programme."
The Midland Sense Groups, including Bromsgrove's, have so far raised £2,000, with funds being used by the charity to invest in a new dedicated research facility. For more on the charity visit tommys.org.


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Catherine Juliet Model
Patrick SimondacPhotographer Male Orlando, Florida, US
My Website: www.patricksimondac.comMy MM URL: http://www.modelmayhem.com/psimondac
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I am looking for MUA/Hair Stylists/Wardrobe Stylists to collaborate and work with to make some cool photos. :)
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Catalina Saavedra
The Maid
When Raquel's (Catalina Saavedra) place in the Valdes family -- for whom she's provided 23 years of maid service -- is threatened after they hire more help, she decides to do something about it in this Golden Globe-nominated comedic drama from director Sebastián Silva. Rolling out anything but the red carpet for the new employees, Raquel's juvenile tricks just might work in this examination of loyalty, family dynamics and duty. Claudia Celedón co-stars.


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Commencement Day
Commencement Day Advisory: Heavy traffic on the University's campus is expected throughout the weekend.
The HTC Center will open one hour prior to the start of the indiviudal College's Ceremonies. Programs will be available for guests at each of the entrances into the HTC Center.
During commencement degree candidates march into the HTC Center students process with their school, behind the university banners listing the name of the school. This ceremony includes addresses from the president, the chairman of the Board of Trustees, and the commencement speaker; honorary degrees are bestowed; and students are officially recognized as graduates of the university.
The ceremony should last approximately one and half hours. Graduates will partake in a Coastal tradition as they recess out of the HTC Center and pass through the Gauntlet. The Gauntlet is a long standing tradition where CCU faculty form a tunnel for students to pass through, enabling the faculty to wish the new graduates luck in their future endeavors. To ensure a quick and safe exit, graduates are urged to make arrangements before Commencement to meet family and friends after the ceremony at a designated location.


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Getting ahead...
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|Comments (6)
What is the best training for becoming a hirable outside sales representative? What types of ongoing training or certifications are necessary to be an effective outside sales representative?
What do non-traditional career paths look like?
Kevin in Columbus, Ohio
106 months ago
Looking for direction on developing an outside sales handbook
JoeB. in Norwalk, California
104 months ago
Host said: What is the best training for becoming a hirable outside sales representative? What types of ongoing training or certifications are necessary to be an effective outside sales representative?
I've been in sales/outside sales for at least 30 years. There are many courses you can take to show you what you should know like do's and don't, but the best is to get out and be yourelf. If you don't you won't last in the school of sales. JB Whittier,CA
wandalassiter in Hyderabad, India
104 months ago
I have been using another powerful marketing tool to promote my business. It is like participating with the members of a certain community. Just like that Mediahalo provides everyone to self market in entertainment industry.
Kevin in Columbus, Ohio
104 months ago
I am responsible for writing a handbook for outside sales personel within my company.I have been in sales for almost 3 years and it has gone remarkably fast.At first I didnt feel qualified to put this hanbook together ,but now I understand why Im doing it.There are no rules.Use the Golden Rules ,Be kind and real and know your stuff and success will follow.
JoeB. in Norwalk, California
104 months ago
Kevin good deal on the handbook. Sometimes we feel less qualified then what we really are. I wrote a Standard Operating Procedure Manuel around 15 years ago and it's still being used today. If we really look inside ourselves to inventory the experiences we've been through I'm certain some of us could write a How to? for profit.
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Arthritis & Rheumatism, Volume 62,
November 2010 Abstract Supplement
Abstracts of the American College of
Rheumatology/Association of Rheumatology Health Professionals
Annual Scientific Meeting
Atlanta, Georgia November 6-11, 2010.
Lack of IL-17RA Signaling Prevents Autoimmune Inflammation of the Joint and Give Rise to a Th2-Like Phenotype in Collagen-Induced Arthritis.
Mus, Anne-Marie, Corneth, Odilia, Asmawidjaja, Patrick, Lubberts, Erik, MC, Erasmus
IL-17A plays an important role in collagen-induced arthritis (CIA). On the other hand, CIA developed normally in IL-17F deficient mice. This could be due to IL-17A that is still expressed in these mice. It has been shown that around 20% of the IL-17A deficient mice still develop marked collagen-induced arthritis with a somewhat lower severity that the control littermates. Spontaneous arthritis development in the IL-1Ra deficient mice could not be completely prevented in double IL-17A/IL-17F deficient mice. However, it is still not fully clear how important the role of the IL-17A and IL-17F signaling is in the development of autoimmune collagen-induced arthritis.
To examine the role of the IL-17RA signaling in the development of CIA.
Since the IL-17RA deficient (IL-17RA-/-) mice can not signal for IL-17A and IL-17F these mice were used in this study and were compared to control mice and the CIA resistant IL-23p19 deficient (IL-23p19-/-) mice. All mice were immunized intra-dermally with chicken type II collagen (CII) in CFA at days 0 and 21. The arthritis incidence and severity were scored macroscopically. In a set of experiments, mice were given a third CII/CFA injection at day 50. At days 20, 34, and 69 sera was collected for CII-specific IgG's measurements by ELISA. In addititon, at days 10 and 69, splenic CD4+ T cells were isolated and intracellular flow cytometry of different cytokines was performed.
CII-immunized control mice developed CIA from day 24 onwards with an incidence between 4060%. As expected, the IL-23p19-/- mice did not develop CIA. Interestingly, the IL-17RA-/- mice were completely protected and did not develop CIA even after a third CII/CFA injection. In contrast to the low percentage of IL-17+ CD4+ T cells in the IL-23p19-/- mice, there was a significant increase in the percentage of these cells in the IL-17RA-/- group compared to the control group at day 69. No significant difference was found in the percentage of IFN-gamma+ CD4+ T cells between all three groups. Interestingly and in contrast to the IL-23p19 knockout mice, the IL-17RA deficient showed a Th2-like phenotype in splenic CD4+ T cells at day 69. No difference was noted for FoxP3 expression in the splenic CD4+ T cells between the three different mouse groups. Moreover, the CII-specific IgG2a levels in the sera of IL-17RA-/- was significantly lower compared to the control group at day 20 and lower although not statistically significant at day 69. At this latter time point, CII-specific IgG1 levels in the sera of IL-17RA-/- was increased although not statistically significant compared to the control.
These data revealed a critical role for the IL-17RA signaling in the development of autoimmune inflammation of the joint. Moreover, these data show a Th2-like phenotype in IL-17RA-/- mice immunized with CII, suggesting that IL-17 receptor signaling is involved in the suppression of Th2 cytokines in autoimmune collagen arthritis.
To cite this abstract, please use the following information:
Mus, Anne-Marie, Corneth, Odilia, Asmawidjaja, Patrick, Lubberts, Erik, MC, Erasmus; Lack of IL-17RA Signaling Prevents Autoimmune Inflammation of the Joint and Give Rise to a Th2-Like Phenotype in Collagen-Induced Arthritis. [abstract]. Arthritis Rheum 2010;62 Suppl 10 :1525
DOI: 10.1002/art.29291