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Kate, mom to 7 year old Djuna and 4 yr old Alden. Missing our good friend Hal the cat who died June 2, 2010
Momma to 8 y.o. DS and 5 y.o. DD. Married to a Maker!
Also, more specifically I'm looking for good-looking-end-result DIY-by-kids Christmas tree ornament ideas (mostly doable by my 5 yr old, but if there are any ideas that a 2 yr old could make that would be great too). This is the first year that we'll be "doing" Christmas at our house, and so the first year that we'll have a tree, so we don't have any ornaments yet. I'd love for most of them to be hand-made. I have a big stash of yarn and fabric and some buttons that could be used, as well as other conventional kid crafty stuff.
Kate, mom to 7 year old Djuna and 4 yr old Alden. Missing our good friend Hal the cat who died June 2, 2010
Last year I was really pleased with how we did an Advent calendar. I got holiday-themed scrapbooking paper and cut it in squares. On each one I drew a picture of and described a special treat for the day. I rolled these up and tied them with ribbon and put a little sticker on the outside with a small symbol so I knew which paper was which. These were all put into a large glass jar. I made myself a key to all the papers. Then each day dh and I would look at what was left on the list and tell dd to find that symbol in the jar. They were almost all things to do: lantern walk at night, tea party, bake cookies with mama, decorate the tree, go out to lunch, etc. A lot of them were things we do anyway, but they were special when they were picked out of the jar. Since they didn't have numbers on them that dd didn't understand anyway, we able to be flexible about when to do the things in the jar.
I'm looking forward to reading through other ideas here, especially since it's almost December! Eek!
Kate, mom to 7 year old Djuna and 4 yr old Alden. Missing our good friend Hal the cat who died June 2, 2010
Mom to DS 12/07 and DD 11/13, plus a bunch of chickens, dogs, and cats.
Moving past many years of infertility and always thinking of my friends in the infertility forums.
|Long ago I made the Advent garland with Christmas-themed baby socks featured in Martha Stewart Kids magazine. There are lots of versions on-line. It's very simple - just take 12 pairs of baby socks (matching or not). I sewed on little package tags numbered 1 to 24. I use mini-clothes pegs to hang them on a red ribbon. It's one of our traditions, so I haven't replaced it with anything else, although I keep seeing terrific ideas.
I don't know about the advent calendar, but let me share my Christmas tree ornament story, if I may
Christmas 11 years ago I was a newly divorced, young, dirt poor mama with three little boys. Somebody gave me a Christmas tree, but I couldn't afford to buy any ornaments or other decorations. At first I was really depressed about it, but then I found some simple cheap ideas for homemade ornaments and decorations, and we would listen to Christmas music and drink hot chocolate and craft away And it turned out to be such a magical Christmas, one of my most favorite ever So to this day I only allow homemade ornaments (mostly the kids, but I make them too) on our tree as a reminder. We try to make something new every year and it's become a favorite tradition.
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Biology in the News
Contemporary Biology N100, Winter/Spring 2004
That's it for the N100 news, but what about tomorrow....??? Keep reading that Science News at Nature Science Updates, Wired, The New York Times, Scientific American, etc ! Have a great summer!
3 May Superbug dodges lab tests Uh oh...Natural selection in action again.... "A new strain of bugs resistant to antibiotics may be eluding routine laboratory tests. More hospitals around the country are reporting that a last line of antibiotic defense - Vancomycin - for hospital-acquired infections has been crossed. Most strains of Staph. aureus, a common skin bacterium that can cause severe hospital acquired infections, have become resistant to common antibiotics such as penicillin for years...and now are becoming resistant to Vancomycin. "We need new antibiotics, it is as simple as that," says Mark Enright, who studies S. aureus at the University of Bath, UK."
30 April 2004 Move back that timeline for fire! Earliest fire sheds light on hominids "Ancient hearths unveiled as nearly 800 millennia old. Archaeologists have collected evidence that early humans mastered fire much earlier than previously thought. There is already good evidence for hearths that are 250,000 years old, and it was widely believed that the first controlled handling of fire occurred 400,000 to 500,000 years ago. But an analysis of burned remains carried out by Naama Goren-Inbar of the Hebrew University, Jerusalem, and her team shows that fire was tamed at least 300,000 years earlier than that. The researchers have spent the past 15 years unearthing and sorting sediments at a site in Israel. The site is of particular interest to archaeologists because it was an old crossroads between Asia and Eurasia. It is also waterlogged, which means that any ancient remains are extremely well conserved." [Image]
29 April 2004: "God, Send a Realistic Tech Flick" Two thumbs down for the new movie Godsend: "In movies, anyone who dares to use a newfangled technology to "play God" almost always opens the 'gates of hell.' Godsend, a new film starring Robert De Niro, Greg Kinnear and Rebecca Romijn-Stamos, is no different. Jessie and Paul Duncan agree to clone their son Adam (Cameron Bright), who was killed by a car when he was 8 years old, but wish they hadn't when the clone starts behaving erratically. The movie is the kind of publicity that people who want to outlaw all human cloning could only dream of. Whether the filmmakers realize it or not, the message is clear: Scientists who want to clone are evil, or mad, or both; cloning should not be done, period." YUK! Bad title, bad science, predictable plot, next year's cloning academy awards nominee!
27 April 2004: Bone marrow stem cells help mend broken hearts Bone marrow-derived (not hES-derived) stem cells may help damaged heart muscle to regrow, a clinical trial suggests. Researchers harvested stem cells from patients with cardiac failure, and then transplanted the cells into their damaged hearts. Six months later, the hearts functioned significantly better than those of patients who had not received the therapy. The results suggest that adult stem cell transplants are a good way to treat heart failure, researchers told the American Association for Thoracic Surgery. An estimated 23 million people worldwide are affected by heart failure."
27 April 2004: "Somebody help me!" Look sharp to save lynx "A conservation expert has sounded an alarm over the dwindling numbers of the Iberian lynx. Unless it can be rescued, the lynx will be the first big cat to vanish completely at the hands of humans. There may be as few as 120 Iberian lynx (Lynx pardinus) left in the wild, says Dan Ward. The cats now consist of just two small populations in southern Spain's Andalusia region, he reports. The lynx is in deeper trouble than other endangered cats such as the Siberian tiger, Ward believes. "They are a more serious problem than tigers," he says. "This is the most endangered feline species in the world." [Image]
23 April 2004: Cretacious extinction update: Did dinosaurs lack daughters? "Dinosaurs may have been forced into extinction partly because there were too few females, say researchers in the UK. The creatures died out roughly 65 million years ago, around the time that a huge meteor slammed into earth. Some scientists believe that the immense dust cloud thrown up caused swings in the climate that the dinosaurs were unable to survive. However, it is not clear exactly how the temperature change killed them off. Now David Miller of the University of Leeds and his colleagues are proposing in Fertility and Sterility that if dinosaurs used temperature to determine the sex of their offspring, climate changes could have messed up the ratio of males to females. This idea is based on the reproduction of modern day reptiles such as crocodiles. Crocodiles' sex depends on the temperature at which their eggs are incubated. Male crocs hatch in moderate temperatures, while females emerge if the heat rises or falls by a few degrees. In the case of dinosaurs, Miller suggests that changes in temperature after the meteor impact favoured the birth of males. Over time females would become rare, causing fewer young dinosaurs to be born and species to dwindle to extinction. "They'd probably have had it," he says." [Image]
15 April 2004: No offense, guys, but...Girl chimps learn faster than boys "Young female chimpanzees are better students than males, at least when it comes to catching termites, according to a study of wild chimps in Tanzania's Gombe National Park. While daughters watch their mothers closely, the boys spend more time monkeying around. The discovery mirrors differences in the learning abilities of human children - girls tend to catch on faster than boys when learning skills such as writing and drawing; manual tasks that are not dissimilar to the chimps' technique of using a stick to fish for termites, says Elizabeth Lonsdorf, now at Lincoln Park Zoo in Chicago. Lonsdorf's team watched eight young males and six young females who accompanied their mothers to termite nests. Female youngsters enjoyed more success than males in catching termites. They also started younger: females picked up the skill at around 30 months of age, whereas males were usually twice as old as that. Whatever pattern a mother showed, her daughter matched it almost exactly. Males were more easily distracted, choosing to spend their time swinging in trees, turning somersaults and wrestling with each other, says Lonsdorf. This failure to pay attention is reflected in their poor termite hauls. The males are not necessarily wasting their time, says Andrew Whiten, a chimpanzee expert at the University of St Andrews, UK. While termites are a valuable food for females, males often catch larger animals such as monkeys. Their rough-and-tumble play may be a way to hone their hunting skills, Whiten suggests..." Something to remember if your future is in elementary ed!! :) [Image]
April 4, 2004: After 17 Years, Brood X is Back, and in the Mood for Love After more than 16 years underground, periodical cicadas from Brood X - numbering in the BILLIONS - will emerge in late May or early June. Brood X (like the Super Bowl and royalty, cicada broods are identified by Roman numbers) has spent the past 16 years as nymphs, growing and passing through five juvenile stages, sucking harmlessly on tree roots all the while. One evening after sunset, the nymphs will emerge, and, in about two hours, molt into adults. Later they'll mate, the females will lay eggs and the tiny nymphs that hatch will fall to the ground, burrow into the soil and settle in for the long wait until 2021... North American periodical cicadas consist of seven species that have become synchronized developmentally: three have 17-year cycles, and four have 13-year cycles. Broods emerge most years, in different parts of the Midwest and East. Fifteen broods have been documented. Scientists suspect species synchronization has much to do with protection from predators. Brood X is the largest brood, and while birds may eat them and people may squash them, billions of them will survive....' [Image] Stay tuned!
March 31, 2004: Cat Cloning Offered to Pet Owners: "The company that funded the first successful cloning of a domestic cat two years ago has gone commercial. The Genetic Savings and Clone company sent an e-mail in early February to their gene-banking clients, offering to clone up to six cats. The cost? U.S. $50,000 each. Clients had less than a month to take advantage of the offer, which ended Friday, February 27..." Note from Dr. Marrs: This is a good article that discusses many of the issues around animal cloning - particularly of pets and endangered species. Thanks to Brittany P. from N100 for sending this one in! [Photograph of cute little Cc copyright Richard Olsenius, Genetic Savings and Clone, Inc.]
March 31, 2004: A few updates to things discussed in class: Endocrinology and Turner Syndrome; "The most commonly prescribed treatment for Turner syndrome (45, X0) includes the use of growth hormone to improve growth speed and final adult height, and estrogen replacement therapy to promote sexual development as should occur during puberty. Estrogen therapy is also important for the development and maintenance of bones. Some patients require other therapies, such as thyroid hormones. Though most Turner syndrome women are infertile, modern reproductive technologies such as in vitro fertilization can be used to help those that want to become pregnant."
Also mentioned in class discussions: March 26, 2004: Senate Outlaws Injury to Fetus During a Crime: "The Senate approved legislation on Thursday making it a separate offense to harm a fetus in a federal crime committed against a pregnant woman. This bill recognizes that when someone attacks and harms a mother and her unborn child, that attack does, in fact, result in two separate victims. The authors of the bill dismissed the claim that it was a back-door attack on abortion rights, saying the legislation specifically exempts abortions consented to by the woman. 'It's not about abortion,' said Senator Lindsey Graham, (R-SC) 'It is about criminals who attack pregnant women'. Opponents of the bill it would ultimately be used as an argument to overturn existing laws protecting abortion rights. Stay tuned...
March 15, 2004: Mooove over, regular milk! Healthier milk straight from the cow: "Cows who are fed a diet rich in rapeseed yield healthier milk - with lower levels of saturated fats- and butter that can be spread straight from the fridge. "This is a healthier balance of fats," says nutritionist Toni Steer from the UK Medical Research Council's Human Nutrition Laboratory in Cambridge. Rapeseed is rich in unsaturated fats, which pass through the cow's digestive system into its milk. One of these fats, called oleic acid, makes butter produced from the milk spreadable when cold. 'Naturally Spreadable Butter', as it is known, is already available from Marks and Spencer supermarkets in the U.K., but the research behind it has only just been published in the Journal of the Science of Food and Agriculture (2004)." Mmm good. Pass the (whole wheat) bread! [Image]
March 14, 2004: NY Times Book Reviews! Need something to read on Spring Break? Well, check out: 'The Great Influenza' and 'Microbial Threats to Health' Read up on some wicked statistics on that most deadly of killers in human history: the 1989 Influenza Pandemic, and some facts about the Top Three today - AIDS, Malaria, and TB.
March 10, 2004: Science at work: Women May Replenish Eggs: Is a textbook re-write necessary? 'The long-held idea that women are born with their lifetime supply of egg cells is now in doubt, and the change could revolutionize fertility treatments. The findings of a new study raise the possibility that women, like men, replenish their reproductive cells throughout life. The research, published in the March 11 issue of Nature, was done in mice, a mammal often used as a model for human biology. If the results can be replicated in humans, the findings will upend a doctrine held by fertility researchers for half a century. The evidence that women are born with the number of eggs they'll have for the rest of their lives was first postulated in 1921. The declaration was solidified with a landmark study in 1951, and it has been a core dogma about female fertility ever since. The new research will surely send many fertility researchers back to their files in hopes of deciphering studies that had previously puzzled them".
February 26, 2004: FDA Approves Avastin, A Targeted Therapy for First-Line Metastatic Colorectal Cancer Patients -- First Anti-Angiogenesis Treatment Approved for Treating Cancer -- "Genentech today announced the FDA approval of a new drug. Avastin is the first FDA-approved therapy designed to inhibit angiogenesis, the process by which new blood vessels develop, which is necessary to support tumor growth and metastasis." Watch out, cancer cells!
Why wasn't this at the Academy Awards? SuperSize Me! Ewww: Filmmaker Morgan Spurlock puts his own body on the line, living on nothing but McDonald's three meals a day, for 30 days ... get ready to see the movie and find out what happened! Thanks to several N100 students for sending this one in!
February 13, 2004: Who knew? After Packing M&M's Together, Scientists Like What They See "In possibly the biggest advance in the science of candy since the discovery that Wint-O-Green Life Savers emit faint blue sparks when chewed, scientists are reporting today that M&M's pack more tightly in your mouth than gumballs." The research, reported in this week's Science, indicates that spheroid shapes (like M&Ms) will randomly arrange into a dense packing structure, resulting in a much higher density than can be filled with spheres. "You can just randomly pour them and without any effort get something that approaches the densest lattice packing," Dr. Torquato said. Science reports: "Not just a theoretical puzzle, the ways in which objects pack are of vital concern to the shipping and manufacturing industries". [Image: guess how much of the of the available space is taken up by these yummy M&Ms!?]
February 12, 2004: Cloning Creates Human Embryos "Scientists in South Korea report that they have created human embryos and extracted embryonic stem cells, the universal cells that hold great promise for medical research. Their goal, the scientists say, is not to clone humans but to advance understanding of the causes and treatment of disease. Patients with diseases like Parkinson's and diabetes have been waiting for the start of so-called therapeutic cloning to make embryonic stem cells that are an exact genetic match of the patient. Then those cells, patients hope, could be turned into replacement tissue to treat or cure their disease without provoking rejection from the body's immune system". We will talk about Human embryonic stem cells in N100 on March 8th.
2/12/03: Happy Birthday to You....Charles Darwin! Charles Robert Darwin was born in the village of Shrewsbury, England, on February 12, 1809 (and died on April 19, 1882). On the same day (February 12, 1809), the 16th President of the United States of America, Abraham Lincoln (1809-1865) was born in Kentucky. Coincidence...OR NOT? (Just kidding.)
"I have called this principle, by which each slight variation, if useful, is preserved, by the term 'Natural Selection'. And I'll have another piece of cake, please."
This is a wonderful article, read it if you get a chance: Darwin's
Influence on Modern Thought
by Harvard Professor of Zoology Ernst Mayr.
February 12, 2004: Oldest Known Insect Identified From 400-Million-Year-Old Jaws "Scientists say they have discovered the world's oldest known insect fossil, a 400-million-year-old set of minuscule jaws that have been lying unrecognized for nearly a century in a drawer at the Natural History Museum in London. "We were at the museum to look at another famous insect fossil," said co-discoverers Dr. David Grimaldi and Dr. Michael S. Engel. But the two could not resist examining the other fragment stored in the same drawer, a curious bit of fossil that had long ago been dismissed as being of little interest. Dr. Grimaldi said, "We looked at each other and said, `Holy moley!' "
February 6, 2004: NOT for the faint-of-heart... Warning: DON'T click on the link unless you are ready to see a rather graphic photo of this explosion. Thar she blows! Dead whale explodes! "Residents of Tainan, Taiwan learned a lesson in whale biology after the decomposing remains of a 60-ton sperm whale exploded on a busy street, showering nearby cars and shops with blood and organs and stopping traffic for hours. The 56-foot-long whale had been on a truck headed for an autopsy by researchers, when gases from internal decay caused its entrails to explode in the southern city of Tainan....." You just don't hear stories like this every day! The decomposition and gas production was probably caused by a bacteria like Clostridium, the genus of bacteria responsible for tetanus, botulism, and gas gangrene...... [Full story and - repeat warning - graphic photo!]
February 5, 2004: Hey, here is a good article in today's IndyStar: The lowdown on carbs - lots of info on one of our FAVE macromolecules, and info on local restaraunts promoting low-carb meals.
Uh oh....Feb 4, 2004: Finding of Ricin in Office Disrupts Senate "The Senate shut down its three office buildings on Tuesday, disrupting the work of lawmakers and thousands of their aides, after a powder identified as the deadly poison ricin was found in the office suite of the Senate majority leader, Bill Frist. Many experts consider the public health risk posed by a mailed poison much smaller than that from a mailed germ, particularly anthrax, which can multiply explosively if only a small number lodge in the lung." However, the presense of Ricin disrupted life for thousands of Washingtonians and tourists in the past few days, and again raises unsettling realities of our vulnerability to bioterrorism through the US mail. Ricin is a toxic protein made from castor beans, and has been used throughout history as a means of suicide, covert assasination, and bioterrorism (read more about ricin here (biology and history) and here (health facts). [Image]
Feb 3, 2004: Latest on the Avian Influenza (Bird Flu) Outbreak: The CDC and WHO are also investigating what "may be the first case of person-to-person spread, among family members who attended a wedding in Vietnam in early January. The groom, 31, and two of his younger sisters died. The bride became ill but recovered and was the only survivor in this cluster."
January 28, 2004: Talk about homeland security! Emerald ash borer nears northern Indiana borders. Indiana is bracing itself from attack by a newly reported beetle in the US that leaped from the continent of Asia (probably carried into the US on imported wood products) and is killing millions of beautiful ash trees (genus Fraxinus) . From the USDA Forest Service: "The metallic, coppery-green Emerald ash beetle has already caused the demise of more than 6 million ash trees in Michigan since it was found in July 2002. Of special concern to Hoosiers are the infestations found just two miles from the Indiana border near Fort Wayne and one found this month in St. Joseph, Mich. This brings the beetle much closer to northwestern Indiana and Chicago"" YIKES! Will we be able to keep this hungry bug out of Indiana? Stay tuned!! Thanks to N100 student William Lawson for bringing this story to my attention! [Image (small but deadly: The Emerald Ash Borer]
January 27, 2004: Rules Issued on Animal Feed and Use of Disabled Cattle WOW! The NY Times reports the FDA's new rules," including a ban on feeding cow blood and chicken wastes to cattle. The agency also banned using dead or disabled cows to make products for people like dietary supplements, cosmetics or soups and other foods with traces of meat. The rules, described by Mark B. McClellan, FDA commissioner, take effect in a few days. Animals can no longer be fed "plate waste," the meat and other scraps that diners leave on their plates in restaurants and that is rendered into the meat and bone meal added to feed. Also banned from products for humans will be the tissues most likely to carry the infectious agent like the brain, skull, eyes and spinal cord of animals 30 months or older and the tonsils and part of the small intestine of all cattle. Because a product called mechanically separated meat may carry infectious tissue, it will also be banned. Finally, the new rules say equipment that makes feed with meat or bone meal can no longer be used to make cattle feed. A remaining loophole is allowing rendered matter from cows to be fed to pigs and chickens and rendered pigs and chickens to be fed back to cows. In theory, that sequence could bring the disease full circle, back to cows...." Let's close that loophole!
January 23, 2004: W.H.O. Seeks Vaccine for New Bird Flu: "The World Health Organization is taking urgent steps to develop a new human vaccine to stop the spread of a new, and highly virulent, H5N1 Avian Influenze Virus. In the 5 cases reported in Vietnam so far, all have been fatal and all the result of contact with infected chickens, and the disease is rapidly spreading to Thailand and Korea. Health officials worry that the new strain might combine with another virus to create a new virus that could spread easily among people. Because the H5N1 strain kills chickens, scientists cannot use chicken eggs in the initial stage of making the vaccine, as they do for human strains of influenza virus. Instead, scientists will be trying a newer laboratory technique known as reverse genetics to develop a human vaccine, and if all goes well, the vaccine will be available in about a month."
January 21, 2004: Sleep A Must For Creative Thinking "German scientists have demonstrated for the first time that our sleeping brains continue working on problems that baffle us during the day, and the right answer may come more easily after 8 hours of rest. Creativity and problem solving appear to be directly linked to adequate sleep, scientists say, but over 70 million Americans are sleep-deprived - a valuable reminder for overtired workers and students that sleep is often the best medicine". So what are you waiting for?!?!
Followup on something mentioned in class Wednesday Jan 15:
Nov 28, 2003: NY Times: A Capitol Hill Mystery: Who Aided Drug Maker? How mysterious..."The Homeland Security Act (legislation to protect Americans from terrorist attacks) signed by President Bush included an 11th hour surprise... a provision that protects Eli Lilly from lawsuits over the preservative thimerosal, a mercury containing compound that may be involved in the development of autism in children. This provision may result in the dismissal of thousands of cases filed by parents on behalf of their children." (Whether thimerosal is truly harmful is still unclear, but neither the anthrax or the smallpox vaccine contains thimerosal...just childhood vaccines.. Hmmm, now HOW is this a matter of domestic security?). The NY Times continues: "Not a single member of Congress — or the Bush administration — will admit to being the author of the Lilly rider..." From Jenny Thompson of the Alternative Medicine Health Sciences Institute " A spokesman for Lilly said that the company knew absolutely nothing about the sweetheart provision. Right. I suppose that includes Sidney Taural, the chairman, president and C.E.O. of Eli Lilly, who has a seat on President Bush's Homeland Security Advisory Council....." Is there a conspiracy theory here???
Thursday, January 15th: Jaguars Breakfast Club,
Lecture Hall from 7:45-9:30 am. mmm...Free
bagels and coffee from Panera Bread, free giveaways from Radio Now 93.1, and
info about the coolest class at
IUPUI, the Urban Percussion Ensemble class (N100 being the second coolest
class at IUPUI...) "The Jag Breakfast Club is designed to give students
useful campus information, Men and Women's Basketball Schedules, Campus Maps,
Shuttle Bus Schedules, and much more. Bonus: You get a front
parking space for being here early!
5 January 2004: SARS returns to southern China. "The World Health Organization (WHO) has confirmed a new case of SARS (Severe Acute Respiratory Syndrome) in China. Chinese authorities announced plans to slaughter thousands of civet cats, ferret-like animals that are a delicacy in China's food markets and are suspected of transmitting the SARS coronavirus to humans." The SARS virus is an unusual entirely new virus related to the common cold virus that is part-animal and part-bird virus in origin. In the last 2 years, SARS has infected over 3,000 people in over 30 countries and has killed over 700 people by causing a severe pneumonia-like infection. [Image]
30 December 2003: First mad cow found in America: "US beef imports were banned by Japan and other countries after the USDA announced the diagnosis of bovine spongiform encephalopathy (BSE), or mad cow disease - in a 'downer' dairy cow, unable to walk yet still sent for slaughter and human consumption". Beef producers in the US have lost their biggest export market, worth ~$1 billion / year. Mad cow disease, or BSE, is of great concern to people because humans can develop a fatal brain-wasting illness similar to mad cow disease, called variant Creutzfeldt-Jakob disease (vCJD), from eating contaminated beef products. While USDA Secretary Ann Veneman has reasured the public that none of the BSE-infected tissues of the dairy cow entered the human food market, the USDA will be under intense pressure to tighten rules for meat production, testing of cattle for BSE, and use of downer cows and their by-products as food for humans or other animals. [Image] Stay tuned...

subset: commoncrawl


text:
His Lordship died at Tunbridge Wells, in 1851, in his sixty-eighth year.
General Toombs was in his sixty-eighth year, but stood the ordeal well.
The same thing is repeated in the sixty-eighth Psalm21 with tender variations.
In the sixty-eighth year of his age he, too, paid the debt of nature.
He was then in his sixty-eighth year, and had lived down most of the hostility which formerly had been so rife against him.
In a few more days he would have reached his sixty-eighth birthday.
There he expired on Sunday the eleventh day of June, in the sixty-eighth year of his age, and in the thirteenth of his reign.
Washington died on December 14, 1799, in his sixty-eighth year.
The reader will find the speculative individuality of Sokrates illustrated in the sixty-eighth chapter of my History of Greece.
On the morning of the 18th of August, 1803, he expired without a struggle, in the sixty-eighth year of his age.


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THE BLACK SUN UNVEILED and the Birthday Child of December 21, 23 , 2012..
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[quote:Anonymous Coward 14392840:MV8xOTgwMDczXzMzMjU2MTUzXzY5OEZBOUM1] [quote:Levski:MV8xOTgwMDczXzMzMjU1OTkwXzQwOTU0OTI1] BTW, OP, singular from illuminati is "iluminat" There is no such word as "iluminist" in latin... Just so you know, I saw that you have changed your moniker [/quote] Yes ! I wanted a name to reflect light that lights up a room, like a light bulb. I didnt want fears and scandal that the name "Illuminati" reflects in society today. Here is a essay thats classic ! THE KINGDOM OF GRACE. the KINGDOM OF THE JUST ...Adam Weishaupt.. ( Bavarian Illumininati) (HISTORICAL ARCHIVES) COPYRIGHT FREE TO QOUTE "Morality alone can do this. The head of every family will be what Abraham was, the patriarch, the priest and the unlettered lord of his family, and Reason will be the code of laws to all mankind. This is our great secret. True, there maybe some disturbance; but by and by the unequal will become equal; and after the storm all will be calm. Can the unhappy consequences remain when the grounds of dissention are removed? Rouse yourselves therefore, O men! Assert your rights; and then will reason rule with unpercieved sway, and all shall be happy." "Morality will perform all this; and Morality is the fruit of Illumination. Duties and rights are reciprocal. Where octavious has no right, Cato owes him no duty. Illumination shows us our rights, and Morality follows; that Morality which teaches us to be of age, to be out of wardenship, to be full grown, and to walk without the leading-strings of Priests and Princes." "Jesus of Nazareth, the Grand Master of our order, appeared at a time when the world was in the utmost Disorder, and among a people who for ages had groaned under the yolk of Bondage. He taught them the lessons of reason. To be more effective, he took the aid of Religion--of opinions which were current--and in a very clever manner, he combined his secret doctrines with he popular religion, and with the customs which lay to his hand. In these he wrapped up his lessons --he taught by parables. Never did any prophet lead men so easily and so securely along the road to liberty. He concealed the precious meaning and consequences of his doctrines; but fully disclosed them to a chosen few. He speaks of a kingdom of the upright and faithful; His Father's kingdom, who's children we also are. Let us only take liberty and equality as the great aims of his doctrines, and Morality as the way to attain it, and everything in the New Testament will be comprehensible; and Jesus will appear as the Redeemer of slaves. Man has fallen from the condition of Liberty and Equality, the STATE OF PURE NATURE. He is under subordination and civil bondage, arising from the vices of man. This is the FALL, and ORIGINAL SIN. The KINGDOM OF GRACE is that restoration which may be brought about by Illumination and a just Morality. This is the NEW BIRTH. When man lives under government, he is fallen, his worth is gone, and his nature tarnished. By subdoing our passions, or limiting their cravings, we may recover a great deal of our original worth, and live in a state of grace. Thus is the redemption of men--this is accomplished by Morality; and when this is spread over the world, we have THE KINGDOM OF THE JUST." -Adam Weishaupt (Founder of Bavarian Illumininati) [/quote]
Original Message
THE BLACK SUN UNVEILED and the Birthday Child of December 21, 23 2012..
The Mural of Bank of America has spawned a lot of Esoteric and Masonic study...It has been compared to the Esoteric Murals of the Denver Airport.
Its always been December 21 or 23
Both dates are used.. My Dell Horoscope mag uses the December 23rd, And here is a explanation from Great dreams .com
The canonical dates (according to Ehran the Scribe) on the ends of the Fourth, Fifth, and Sixth worlds are August 12, 3113 BCE (the fall of Atlantis), December 24, 2011 CE (the appearance of Ryumyo), and April 4, 7137 CE. This gives 5123-5125 years per mana cycle [1,871,270 days for the Fifth World's duration, and 1,871,969 for the Sixth World's]. The Mayan Long Count suggests 1.872M days, or 5125.36 years. It also seems that Ehran's dates are a year late (0.0.0.0.0 should be August 11 or 12, 3114 BCE— the astronomical year –3113) and a year early (184.108.40.206.0 corresponds to December 21 or 23, 2012).
link to www.greatdreams.com
(DISCLAIMER: For Esoteric Theological Research /Entertainment only. Nothing is implied of the actual artist intent, nor Bank of America)
The one on the furthest right is called Planning/Knowledge. and features a blonde boy of about five years old standing in front of a Pyramid and atop a red and white checkerboard floor. Businessmen look at him as if puzzled.
Now lets look back to a different year..
Planning was undertaken for many years to await the December 23, 2007 alignment that created a Grand Cross in the Sky... The Sun was to conjunct Jupiter, Mercury , Pluto to create the top of the upright beam, Venus in Scorpio was to create the left hand cross beam reflective of the passions of paganism, and Neptune and Chiron was to create the right hand cross beam reflective of the flood judgment of Yahweh.
The Moon opposeth at the bottom of the Upright beam along with the Moon at the feet of the Woman and Mars which represented the Soldiers spear.
Now we flash forward to five years on December 21, 23, 2012 of the Mayan Calendar Prophecy..
December 21, 23 2012,
"Happy Birthday Fresco Boy ! . The Woman was Impregnated by Saturn.. the Cube of New Jerusalem had begun .
SOL INVICTUS and his Christmas Birthday was the reason for the season..
Lets look at the image of the Black Sun of Saturn and Nigredo.. In December 23, 2007, Saturn was in Virgo, (the woman) and opposed Uranus in Pisces. This was the descent of the Philosopher King when at Noon you had the Aries Ascendant. This created a Square alignment across the sacral chakra of the one impaled.. As mythology attests, Uranus was castrated and so was Osiris.
The Black Sun (invisible) is also alchemical body besides the nigredo of saturn. The Mystery alignment is called.
Black Sun Feast Day...
December 24th, when it conjuncts the visible Sun
Underneath the Black Sun is a cube with a woman ascending under its rays, (beams)
This can be explained in the Rebis Alchemical formula that was pictured in the Black Eyed Peas Video. (Meet me Halfway)
Finalizing the Cube and Pyramid is the Triumphant alignment of the Trine and the Cross resulting in a cube of the alchemical marriage...
BOY (Manchild) AROUND 5 years old...
The Burning Bush of Moses proclaims, I am that I am..under the fire of Aries, the Acendant of the Alpha.
The key phrase for Aries is "I am"
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text: On 26/05/10 04:41, Garrick Staples wrote: > Wait a minute, till 'qstat -r' shows walltime usage for all jobs > Restart pbs_server In between those two I'd suggest you take a backup of the PBS servers spool directory as running the new pbs_server is likely to upgrade those files to a version the old one cannot read and prevent you from reverting should you need to. Only really applicable across major versions mind you. cheers, Chris -- Christopher Samuel - Senior Systems Administrator VLSCI - Victorian Life Sciences Computational Initiative Email: samuel at unimelb.edu.au Phone: +61 (0)3 903 55545 http://www.vlsci.unimelb.edu.au/ -------------- next part -------------- An HTML attachment was scrubbed... URL: http://www.supercluster.org/pipermail/torqueusers/attachments/20100602/1ad805db/attachment.html


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Take CableTV.com's Advice and Make DIRECTV Your Next TV Service Provider
Using rating data collected from a number of independent consumer surveys, we have analyzed each of the cable companies and other television services available in your area and ranked them in order to help you determine which one is right for your household. Based on this information, we've ranked DIRECTV as the top TV service provider among all satellite TV and cable companies in Kennan, WI.
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text:
Christophe Pillet
Christophe Pillet
Christophe Pillet's work ranges from furniture and glass to interior and product design, for such clients as Cappellini. His honors include Creator of the Year at the Salon du Meuble, Paris (in 1994); a Carte Blanche grant from the VIA (French Furniture Association; 1994); and the Excellence Prize in Lighting at the Salon International du Luminaire, Paris (1995).
Year Born:
Current Location:
Country of Birth:
* Designer biographies provided by Merrell Publishers, London and New York.


text:
Wiscon Electronics (Shenzhen) Co., Ltd.
Onsite Check
The supplier's company premises has been checked by Alibaba.com staff to ensure onsite operations exist there. A third-party verification company has confirmed the legal status of the supplier.
|Business Type:
|Manufacturer, Trading Company
|Guangdong, China (Mainland)
|Main Products:
|Adapter (Only for oversea),Charger,LED Driver,Industrial Power
|Total Employees:
|11 - 50 People
|Total Annual Revenue:
|US$50 Million - US$100 Million
|Year Established:
|Top 3 Markets:
|North America 38.10% Domestic Market 29.80% Western Europe 10.50%
WIS Electronics (shenzhen) Co., Ltd , established in 1996, is one of the largest professional manufa...
WIS Electronics (shenzhen) Co., Ltd , established in 1996, is one of the largest professional manufacturers of power supply products in China. We have a wide range of power supplies products, covering AC/DC linear adapters, AC/DC switching power adapters, Industrial power supplies, battery chargers and AC/DC converters. Our company can provide various specifications with worldwide safety approvals, such as UL, CUL, GS, TUV, CE, PSE, SAA, BC and CB.
Certified by ISO9001 and ISO14001, our company has not only the good quality control system, but also strong R&D team to support customized power supplies based on our full production machines and facilities support. Now our company has employee of over 3000 people and the daily yield are 100,000pcs. Over the past few years, our company has been cooperating with many customers both at home and abroad, including some famous brands for their different projects, such as communication, networking, and other home appliance equipment.
Our goal is to offer the best solution to satisfy every requirement of our customers. What we can promise are not only the strong and quick research and development, but also the competitive price and professional service to meet your satisfaction. You are welcome to contact us today for any inquiries and requirements.
Trade Capacity View More >
Trade & Market
|Main Markets
|Total Revenue(%)
|North America
|Domestic Market
|Western Europe
|Eastern Asia
|Central America
|South America
|South Asia
|Eastern Europe
|Northern Europe
|Southeast Asia
|Southeast Asia
|Export Percentage:
|71% - 80%
|Export Mode:
|Have Own Export License
|No. of Employees in Trade Department:
|21-50 People
Email to this supplier
- Company Overview
- Company Introduction
- Company Capability
- Trade Capacity
- Production Capacity
- R&D Capacity
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text:
mariah885's Mom Answers Activity
is it safe to have a sex three weeks after a c- section? Watch this
Most recent answer (01/06/2012):
i had vaginal birth 2 months ago,should I engage to sexual activity with my husband or its still early?posted by a BabyCenter Member
How can i set boundaries with my mother in law??? Watch this
Most recent answer (08/12/2011):
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What is your menstrual cycle like after a tubal ligation? Watch this
posted by theshannons3 03/08/2009


text:
SLAVEINFO-L ArchivesArchiver > SLAVEINFO > 2000-01 > 0949192617
From: Truman Adkins <>
Subject: [SI] Stovall family, Henry County, Virginia
Date: Sat, 29 Jan 2000 19:36:57 -0500
The following information I gathered recently for correspondants, I am
posting here in the hope others from this family will benefit:
Joseph Stovall was a wealthy landowner in Henry and Patrick Counties,
Virginia. In 1844 his nephew, Thomas Penn, had him declared incompetent. In
Will Book 4, pg. 507 in Henry County there is a notation from 16 December
1844 to the effect "negros hired out" to someone who would pay Stovall's
administrator for their use. When Joseph Stovall died in the 1850's, the
other relatives discovered Penn had mismanaged things and sued him.
In Will Book 6, pg. 49, there is an inventory of Stovall's remaining
personal peroperty made that included:
1 negro man named Marshall $700.00
Lewis $400.00
George $1,000.00
Brice $1,200.00
Woodson $1,000.00
Quince $1,000.00
1 negro woman named Amy $150.00
This inventory is dated 11 May 1857 and was made by R.G. Lamkin, Johnson G.
Giles, John O. Redd and Sherriff Jefe Wootton. There was also a notation
that the person who had hired them out was Wm. P. Thompson who had posted
bond of $225.00.
On pg, 151 of the same book there is the disputsal of the estate, which
shows payments to the Danville Register (Newspaper where the sale of the
slaves was probably advertised) and a note that Thompson received
compensation because he claimed "one or two of the negro hires were diseased".
Henry County Cohabitation List, pg. 132 (1866)
Stovall, Brice, 32, born Henry County, resides in Henry County, Farmer,
Last Owner: Wm. Mills of Henry County, began cohabitation in 1859.
Stovall, Louisa, 20, born Henry County, resides Henry County, Last Owner:
Brice Holland of Henry County.
Stovall, Emma, 6
Stovall, Marshall, 2
- --------------------------------------------------------------------------
Vol. 13, pg 10, Henry County Bicentenial Papers, taken from Minute Book 5,
pg. 273, Henry County Circuit Court Clerks Office. 13 April 1857, Brett
Stovall vs. Joseph Stovall's Administrator, et al., having advertized in
the Danville paper for four consecutive weeks, it is ordered the
commissioner, Wootton, sell the following slaves at public auction: Amy,
Lewis, Marshall, George, Brice, Woodson, and Quincy.
- --------------------------------------------------------------------------
1870 Census, Henry County, Va., Leatherwood District
Stovall, William B., 14, M,B, Farm laborer
emunerated with Stephen Holland, a 38 year old white farmer.
1900 Census, Henry County, Va., Horsepasture District, pg. 48
Stovall, Marshall, B,M, April 1864, married 8 years
Stovall, Mary, wife, B,F, May 1873, mother of 4 children, 4 living
Stovall, Annie, daughter, July 1893
Stovall, Sallie, daughter, April 1895
Stovall, Harry, son, February 1897
Stovall, Rosa, daughter, January 1899
1900 Census, Martinsville District,
Stovall, Quince, December 1864, married 9 years
Stovall, Emma, August 1863, wife, mother of 5, 4 living
Hairston, Samuel, December 1879, step son
Hairston, Wm. , May 1882, step son
Hairston, Bettie, May 1885, step daughter
Hairston, Mandy, May 1887, step daughter
1900 census, Henry Co., Va., Horsepasture District, pg. 47
Stovall, Peter A., B, M, Sept 1881, single
1910 Census, Henry County, Va., Martinsville Dist.
Stovall, Quince, 48, M,B, married 21 years
Stovall, Emma, 46, F,B,
Stovall, Mandy, 20, F,B,
Henry County Marriages:
6 December 1891,
J.M. Stovall, 28, single, born and resides in Henry County, s/o B & L Stovall
Mary E. Key, 18, single, born and resides in Henry County, d/o J & SE Key
26 December 1889
Quince Stovall, 22, single, born in Henry County, s/o B&L Stovall
Emma Hairston, 26, widow, born in Henry County, d/o _____& Rose Hairston
This thread:
|[SI] Stovall family, Henry County, Virginia by Truman Adkins <>


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Animal lovers and cat enthusiasts are invited to the International Cat Association's (TICA) 2012 Southwest Regional Cat Show Friday through Sunday at the Doubletree Hotel, 445 S. Alvernon Way.
Admission is $5 for adults, $4 for seniors and $3 for children, or guests can bring a food donation for $1 off admission.
"Best of breed" and "best of show" competitoons will be held, and vendors will offer a wide range of cat products.
Organizers also promise a special guest appearance by "Motzie," billed by the Guinness Book of World Records' as the world's "third tallest cat".


text:
Welcome to the ISU Studio for New Media
The Studio for New Media researches both theory and production of new media, such as the Web, CDs, DVD/Blu-Ray, streaming multimedia, web applications, social media and digital humanities in all media.
The Studio for New Media is an interdisciplinary research institute organized to support, further, and coordinate work with digital media and digital humanities currently done by individuals across multiple departments at ISU. The SNM opened its offices in Ross Hall (Iowa State University, Ames, IA) in Summer 2005.
Some parts of this website are only available to SNM members--they won't be visible until you are logged in as a member (about membership). But even if you aren't yet a member, please feel free to explore the public sections of this website and to contact us to discuss possible collaborations.


text:
Blast Friday
This street festival features live music, a variety of vendors, food, beer, wine and non-alcoholic beverages.
Cleveland Street District, Downtown Clearwater
Go to blastfridayclearwater.com for more information
Armed Forces Military Museum
The Armed Forces History Museum is proud to announce the 2013 Maggi Tax Advisory and Veteran Solutions Special Event Series.
Armed Forces History Museum
2050 34th Way North, Largo
Taste of Pinellas 2014
This year's Taste, scheduled Friday and Saturday, May 9-10, brings an updated combination of local food, celebrity headliners, music and family fun to an all-new venue - Albert Whitted Park in downtown St. Petersburg.
This community event was created as a fundraiser for All Children's Hospital more than 26 years ago. Over the years, Taste of Pinellas has raised hundreds of thousands of dollars for All Children's, the most advanced children's hospital on Florida's west coast.
Musical Line Up:
Friday: Gates open at 3:30 p.m. Music from 4-10 p.m.
4 p.m. T.C. Carr and The Bolts of Blue Band
5 p.m. Loverboy
6:30 p.m. Bruce Hornsby and The Noisemakers
8:30 p.m. Pat Benatar & Neil Giraldo
Saturday: Gates open at 3 p.m. Music from 3:30-10 p.m.
3:30 p.m. Dan Orlando Band
5 p.m. The Black Honkeys
6:30 p.m. KC and The Sunshine Band
8:30 p.m. The Blues Brothers starring Dan Aykroyd and Jim Belushi
Advance GA tickets are $22.50 and $25 at the gate. Tickets may be purchased at Ticketmaster.com, local Rally stores, the gift shop at All Children's Hospital or The Mahaffey Theater Box Office.
VIP tickets can be purchased online for $75.
Please visit our website for more information: www.tasteofpinellas.com
Address: 400 First St. S, St. Petersburg, FL 33701
Contact email: email@example.com
Contact phone: (727) 892-5767
Box Office phone: (727) 893-7832 Box Office hours: 11am-5pm Monday-Saturday
105 Central Park Dr, Largo
largo arts.com
The Palladium at St Petersburg College
253 Fifth Ave N, St Petersburg
Straz Center
Downtown Tampa
Gulfport Tuesday Fresh Market
Tuesdays 9am-3pm year round
Fresh fruits and vegetables, live music, plants, crafts, baked goods and more. On the second Tuesday of every month, Gulfport's free clothing swap takes place during the Fresh Market. Swap hours are 9am to 1pm and takes place near The Outpost on the corner of Beach Blvd. and 30th Ave. South. Participants may bring up to five gently used garments, shoes or accessories to exchange for vouchers that may be used to select items brought in by other participants. Clothing may be for women, men or children. Please provide hangers for all garments to be used in the swap. Vouchers may also be purchased for $3 each.
Beach Blvd, Gulfport
Hideaway Cafe52 Weeks to Win!
Love to win? You still have dozens of chances to visit one of our "52 Weeks to Win!" partners and register to win free tickets to a show at The Mahaffey Theater.
Enjoy the intimate vibes of The Hideaway Cafe (1756 Central Ave, St. Petersburg) and register to win tickets to Steve Martin and the Steep Canyon Rangers featuring Edie Brickell.
An extra bonus: On your next visit to The Hideaway after the May 23rd show, bring your ticket stub and save 10% off your entire tab!
The Mahaffey Theater
Murder Mystery Dinner Train Fall Festivities
Fall Festivities with Get-Away Packages with hotel and breakfast with prices starting at $116
2805 Colonial Boulevard
Fort Myers, FL 33966
'Ageless Grace' Classes
Every other Thursday from 11 to 11:45 a.m.
The Clearwater Aging Well Center is offering Ageless Grace classes, a gentle, chair-based movement fitness class.
The classes were developed in cooperation with a Duke University-affiliated hospital. The program includes 21 specific movements that maximize joint mobility, spinal flexibility, right/left brain coordination, cognitive function and balance to promote complete health.
Registration is required and fees run from three and five dollars per class with and without City of Clearwater recreation passes.
For schedules, registration and additional information, call 724-3070.
The Clearwater Aging Well Center
1501 N. Belcher Rd.
Friday May 9 - 8pm
A Musical Affair
Performing the greatest songs of Broadway
Straz Center
Morsani Hall


text:
This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
Recent advances in the field of RNA research have provided compelling evidence implicating microRNA (miRNA) and long non-coding RNA molecules in many diverse and substantial biological processes, including transcriptional and post-transcriptional regulation of gene expression, genomic imprinting, and modulation of protein activity. Thus, studies of non-coding RNA (ncRNA) may contribute to the discovery of possible biomarkers in human cancers. Considering that the response to chemotherapy can differ amongst individuals, researchers have begun to isolate and identify the genes responsible. Identification of targets of this ncRNA associated with cancer can suggest that networks of these linked to oncogenes or tumor suppressors play pivotal roles in cancer development. Moreover, these ncRNA are attractive drug targets since they may be differentially expressed in malignant
Use of predictive biomarkers should be an integral part of current clinical practice and be used as an aid to clinical experience and expertise in making patient therapy decisions.
Since the first miRNA was discovered [
In addition to well-described microRNAs, the growing knowledge of the mammalian non-coding transcriptome is revealing that the genome is also replete with highly conserved large ncRNAs (lncRNAs), which could have a major role in the development and progression of cancer [
Given the larger and growing focus on targeting RNAs for disease therapeutics, what we do know about the intrinsic biology of these small RNAs (miRNA) and long non-coding RNA (lncRNA) makes them potentially attractive targets for pharmacologic manipulation and prognosis markers.
The miRNA was referred initially as small temporal RNA (stRNAs) whith appearance during development [
In contrast to miRNAs, lncRNAs are mRNA-like transcripts ranging in length from 200 nt to ~100 kilobases (kb) lacking significant open reading frames. Many identified lncRNAs are transcribed by RNA polymerase II (RNA pol II) and are polyadenylated, but this is not a fast rule [
Large ncRNAs were first described during large scale sequencing of full-length cDNA libraries in the mouse [
Less than 2% of the total genome contains only 20,000 protein-coding genes whereas a substantial fraction of the human genome can be transcribed, yielding many short or lncRNAs with limited protein-coding capacity. Between them, lincRNA are mostly identified (>3000) but a few have been characterized (<1%).
Some lncRNAs are preferentially expressed in specific tissues [
To hypothesize which miRNAs could be involved in translational regulation of candidate target even is necessary carried out an
Features of malignant tumors, distinct from benign tumors, include invasion and metastasis. miR-21 is one of the most frequently upregulated miRNAs in cancers. In colorectal cancer (CRC), miR-21 promotes invasion, intravasation, and metastasis by downregulating
We will focus on CRC carcinogenesis process and considering the recent up-date "the tumor hallmarkers" [
miRNAs act throught a post-transcriptional regulation that depends on the degree of complementarity between a miRNA and its target. Imperfectly base-pair with sequences in the 3′-UTR of target mRNAs and miRNA inhibit protein synthesis by either repressing translation or promoting mRNA deadenylation and degradation. On the other hand, when a miRNA and an mRNA exhibits perfect complementarity, the target mRNA is cleaved by RISC [
Prediction of miRNA targets is one of the most important fields in miRNAs research, given that miRNAs exert their function by regulating target mRNAs. The specificity of miRNA–mRNA interaction is mainly conferred by the first eight nucleotides of a miRNA (known as seed sequence). However, the likelihood that a predicted target is a bona fide target is influenced not only by seed pairing but also by other factors such as the number of target sites, the context of surrounding sequence in mRNA [
Very little is known about lincRNA biogenesis, in contrast with miRNAs, previous mechanisms of processing are not necessary for lincRNAs. These long non-coding RNA are exclusively intergenic and are marked by a chromatin signature indicative of transcription [
Mechanisms of action of lincRNAs represented by two of them closely related to cancer developement: lincRNA-p21 described as tumor suppressive and lincRNA-HOTAIR as oncogenic (
At the time of this writing it review, the latest version of the Sanger Institute miRBase (V16) [
Many evidences have indicated that miRNAs are involved in the tumorigenesis of many human cancers and, since their discovery, close to 3000 publications associate miRNAs to cancer, including over 700 reviews.
Cancer-associated genomic regions could be disrupted by chromosomal abnormalities, which include minimal regions of loss of heterozygosity, regions of amplification
In this sense, the initial support for the involvement of miRNAs in cancer came from identification of miR-15a and miR-16a in the chromosome region 13q14, commonly deleted in human chronic lymphocytic leukemia (CLL). Expression analysis reported by Calin
It has been predicted that miRNA regulate near 20% to 30% of genes [
Some lincRNAs modulate tumor suppressor pathways, like linRNA-p21, directly induced by p53 to play a critical role in the p53 transcriptional response. LincRNA-p21 functions as a gene repressor by interacting with hnRNP-K protein, allowing its localization to gene promoters to be repressed by p53 [
The central role of miRNAs in development and their direct effects in global gene regulation can indicate that miRNAs are important markers for human cancer. It has been suggested that the tumor miRNA profile may resemble that of their antecedent stem cells and thus reflect development lineage. In this sense, Lu
Colon cancer is also associated with altered miRNA expression. Michael
Many studies have highlighted the biological importance of miRNAs in CRC development, including genesis, progression and response to treatments. These studies have shown that many proteins involved in key signaling pathways of CRC, such as members of the Wnt/β-catenin and phosphatidylinositol-3-kinase (PI-3-K) pathways, KRAS, p53, extracellular matrix regulators, as well as epithelial-mesenchymal transition (EMT) transcription factors, are altered and seem to be affected by miRNA regulation in CRC [
The Wnt/β-catenin pathway plays a central role in an early colorectal tumor development. Inactivation of the adenomatous polyposis coli (APC) gene is a major initiating event in colorectal carcinogenesis occurring in more than 60% of colorectal adenomas and carcinomas and leading to stimulation of the Wnt pathway via free β-catenin [
Another important key signaling pathway in CRC development is the EGFR pathway. Stimulation of EGFR and, subsequently, KRAS signaling lead to the activation of numerous signal transduction molecules initiating a cascade of downstream effectors that mediate tumor growth, survival, angiogenesis and metastasis in a broad spectrum of cancers, including CRC. KRAS oncogene has been reported to be a direct target of the let-7 miRNA family and of miR-143 [
EMT is the conversion of an epithelial cell into a mesenchymal cell. Morphologically, EMT is characterized by a decrease of E-cadherin, loss of cell adhesion, and increased cell motility leading to promotion of metastatic behavior of cancer cells (including CRC) [
Overexpressed cyclooxygenase-2 (COX-2) strongly contributes to the growth and invasiveness of tumor cells in patients with CRC [
Macrophage migration inhibitory factor (MIF) is an innate cytokine, which plays a critical role in the host control of inflammation and immunity, and MIF could inhibit p53 tumor suppressor activity [
On the other hand, we showed recently the functional effects of miR-192/215 on cell cycle, likely due to their pleiotropic mechanism of action, reduce the 5-fluorouracil (5-FU) activity. 5-FU is an S-phase specific drug and previous studies underline the determinant role of cell cycle regulation in 5-FU sensitivity [
Our findings also suggest a potential role of these miRNAs as biomarkers in CRC. According with recent studies [
Regarding lincRNAs, a recent study reports association of HOTAIR expression and poor prognosis in CRC [
Altogether these studies underscore the key role of miRNAs and recent described lincRNA in cancer development, including CRC. To improve the knowledge of the roles of miRNAs in CRC pathogenetic pathways, functional effects of particular miRNAs have been successfully studied showing that epigenetic regulation by miRNAs and some lincRNA (as HOTAIR) in CRC is highly critical and complex (
Comparison of the expression patterns of miRNAs and the potency patterns of 3089 chemical compounds has shown significant correlations, suggesting that miRNAs have a role in chemoresistance [
Resistance of cancer cells to chemotherapy continues to be a major clinical obstacle to the successful treatment of cancer [
Cancer stem cells (CSC) are a small subpopulation of cells identified in a variety of tumors that are capable of self-renewal and differentiation. Deregulation of stem cell self-renewal is a likely requirement for the initiation and formation of cancer. Furthermore, cancer stem cells are proving to be a very likely cause of resistance to current cancer treatments, as well as relapse in cancer patients.
Genetic, epigenetic and the post-transcriptional regulation by miRNAs of genes involved in CSC maintenance, also contribute to drug resistance.
Let-7g and miR-181b were also shown to be associated with chemosensitivity to S-1 (a pro-drug of 5-FU) based chemotherapy in colon cancer. The roles of let-7g and miR-181b in chemosensitivity are associated with their regulation of several genes such as RAS, cyclin D, C-MYC, E2F and cytochrome C [
MiR-34a was identified as one of the down-regulated miRNAs in human CRC 5-FU-resistant DLD-1 cells compared with those in the parental DLD-1 cells. miR-34a was also found down-regulated in drug resistant prostate cancer cells and ectopic miR-34a expression resulted in cell cycle arrest and growth inhibition and attenuated chemoresistance to the anticancer drug camptothecin [
Recently, Valeri
Another study determined that 5-FU and oxaliplatin (L-OHP) down-regulated the expression of miR-197, miR-191, miR-92a, miR-93, miR-222 and miR-826 in HCT-8 and HCT-116 colon cancer cells [
Many efforts have been exerted in analyzing the role of miRNAs in the development of drug resistance in a variety of malignancies, including CRC. Several research groups have shown that the expressions of miRNAs in chemoresistant cancer cells and their parental chemosensitive ones are different. The molecular targets and mechanisms of chemosensitivity and chemoresistance are also successfully studies. These results suggest a great potential for miRNAs as predictive biomarkers and chemotherapy modulators.
Although single-nucleotide polymorphisms (SNPs) in miRNA regions are rare and considered unlikely to be functionally important [
In this sense, SNPs in miRNA-biogenesis genes might affect the expression of mature miRNAs and consequently miRNA-mediated regulation within the cell.
Recently, we developed a study of SNPs involved in miRNA biogenesis in a group of CRC patients homogenously treated with 5-Fluorouracil plus Irinotecan to investigate whether these polymorphisms may influence the outcome of metastatic colorectal cancer (mCRC) patients [
Interestingly, when we performed the
On the other hand, the first epidemiological study showing an association between microRNA-binding SNP sequences and cancer risk was performed by Landi and co-workers [
In a more recent study of early stage CRC patients, a SNP in a
A number of studies based on expression profiling have proven that there are significant changes of miRNA expression levels in CRC tissue in comparison to normal colorectal epithelium. Moreover, comparing miRNAs expression in groups of patients with different clinical outcome have been identified several miRNAs with prognostic value.
Recent studies on miRNAs have shown that the expression levels of different miRNAs, such as miR-21, miR-320, miR-498, miR-106a and miR-200c correlate with the probability of recurrence-free survival in CRC stage II-III. Schetter
Similar associations have been found by other research group. Schepeler and colleagues [
Another study found that miR-21 and miR-31 were significantly up-regulated, and miR-143 and miR-145 down-regulated in tumors compared with the normal counterparts. High expression of miR-21 was associated with lymph node positivity and distant metastases and tumors >50 mm in maximal tumor diameter were related to lower expression of miR-143 and miR-145 [
Some groups also demonstrated that miRNAs expression is associated with microsatellite status in CRC. Twenty-three colon cancer samples characterized by microsatellite stability (MSS), and 16 by high MSI were studied for genome-wide expression of miRNA and mRNA. Eight miRNAs was found correctly distinguish MSI-H
Overall, these findings suggest that a growing number of miRNAs appear on the potential biomarker candidates list for CRC. An important advantage of using miRNAs for biomarker identification is the stability of the miRNAs in archival specimens. This is a key factor in large-scale retrospective biomarker discovery studies. The different length of formalin fixation time and paraffin embedding has little impact on miRNA stability. This is evidently explained both by the shortness of the molecules as well as protection from degradation by intimate RNA-protein interactions. Other factors may be that miRNA sequences could have evolved to elude RNA nucleases. Whereas mRNA tends to be labile in fixed and/or embedded tissue [
Under disease conditions such as cancer, miRNAs entered circulation predominantly from tumor cells [
Studies developed three years ago showed potential use of miRNAs as novel candidates of diagnostic and/or prognostic "circulating marker" of several cancer types [
Although the analysis of circulating miRNAs from serum over plasma or even whole blood are promising for systemic miRNA study, their future application for diagnosing or prognosis of human cancers is questionable and there is no consensus on the optimal circulating medium or isolation technique from which to quantify these miRNAs. Accumulating evidence supports
The fact that miRNA dysregulation in cancer has a pathogenic effect provides the rationale for using miRNAs as potential therapeutic targets in cancer.
Typically, miRNAs that serve as oncogenes are present at high levels in tumors, which inhibit the transcription of genes encoding tumor suppressors. Conversely, tumor suppressor miRNAs are present at low levels, resulting in the overexpression of transcripts encoded by oncogenes.
For miRNAs with oncogenic capabilities, potential therapies include anti-miRNA oligonucleotides, microRNA sponges, miRNA masking, and as small molecule inhibitors. For tumor suppressor miRNAs, restoring suppressor miRNAs by forced expression of those miRNAs may be a useful strategy. In several tumor types with global decreasing miRNA biogenesis, approaches to enhance miRNA biogenesis processing can also represent a valid therapeutic action.
The binding of miRNAs to their mRNA binding targets are simply and elegantly governed by the rules of Watson–Crick base pairing. Therefore, an obvious inhibitory molecule of miRNA is anti-miRNA oligonucleotides (AMOs) which blocks the interactions between miRNA and its target mRNAs by competition. AMOs are chemically modified in a variety of ways, such as with locked nucleic acid (LNA) [
A critical role of mir-21 in cell proliferation by down-regulating the tumor suppressor genes Tpm1 and PTEN has been suggested in [
Small molecule inhibitors against specific miRNAs have also been investigated. Gumireddy
Other inhibitory molecules correspond to microRNA sponge, a synthetic mRNA containing multiple binding sites for an endogenous miRNA, therefore preventing the interaction between miRNA and its endogenous targets. Thus, to increase the efficacy of AMOs, Ebert
Consider that each miRNA may regulate hundreds of genes, and each gene can be regulated by multiple miRNAs, the possibility that miRNAs can affect multiple targets with a single hit, represents an advantage of miRNAs over siRNA/shRNAs (small interfering RNA and short hairpin RNA, respectively). However, similar to siRNA/shRNAs, miRNAs may also interact with multiple targets and this effect is seen as a disadvantage, because off-target effects are largely unpredictable. Similar to endogenous miRNA, the action of AMOs is sequence-specific but not gene-specific. Thus, AMOs may elicit off-target side effects and unwanted toxicity. Xiao
On the other hand, restoring expression of miRNAs with tumor suppressive properties might be a successful strategy and can be achieved by transfecting miRNA mimics either directly or through vectors. For example, to re-introduce miR-34 and its tumor suppressor capabilities, transfection with miR-34 mimics into cancer cells was shown to block the cell cycle in the G1 phase, significantly increasing activation of caspase-3, and knocked down its downfield targets of bcl-2, Notch, and HMGA2 [
Given the role of miRNAs deregulation in cancer stem cells, restoring the expression of miRNAs specifically down-regulated in CSC has been developed. In this sense, a lentiviral system restored the tumor suppressor effect of miR-34 in pancreatic cancer stem cells [
However, from a clinical/translational research point of view, for the miRNA-based therapeutics to be effective, the efficient and functional delivery of miRNA mimics and/or antagonists to tumor remains a great challenge. In this sense, viral and non-viral delivery systems have been developed.
Viral vector-directed methods show high gene transfer efficiency but are deficient in several areas. The limitations of a viral approach are related to their lack of tumor targeting and to residual viral elements that can be immunogenic, cytopathic, or recombinogenic. On the other hand, non-viral gene transfer vectors could circumvent some of the problems associated with viral vectors. Progress has been made toward developing non-viral, pharmaceutical formulations of gene therapeutics for
Therapeutic delivery of synthetic mi-RNA, using a neutral lipid emulsion (NLE), exhibited tumor-inhibitory effects of
Through pre-clinical assays, it was established that small-interfering RNA (siRNA) molecules could be delivered to prostate tumor cells in a bone metastatic site using an atelocollagen delivery method. Further, reduced expression of cancer-related genes in miR-16-transfected prostate cancer cells was analyzed and verified that genes associated with cell-cycle progression were mostly down regulated by synthetic miR-16. In this study, atelocollagen facilitates the accumulation of enough synthetic miRNA in the cancer cells. These results suggest the therapeutic potency of miR-16 in bone metastatic prostate cancer [
Another more recent pre-clinical study, identified and validated miR-34a as a novel therapeutic agent against prostate cancer stem cells (CSCs) by direct functional targeting of CD44 cells [
Finally, with all the efforts and advances made in developing miRNA-mediated therapy, two major hurdles still remain. The first is to maintain target specificity. It is especially challenging since off-target gene silencing only requires partial complementary binding between miRNA and protein-coding transcripts. Therefore, it is important to evaluate the effect of a specific miRNA-mediated therapy on a proteome-wide scale to prevent unwanted gene alteration.
The second hurdle is to achieve high therapeutic efficiency. Two factors that can limit miRNA therapeutic efficiency is the amplitude of target gene modulation and the number of cells that can be targeted. To address the first limitation, one should optimize target gene selection as well as therapeutic molecule design. The second limitation comes from delivery efficiency.
Altogether these studies have indicated that miRNAs can serve as novel therapeutic targets for cancer. However, many challenges remain open. Although this kind of therapy is still a long way from fruition, as many issues need to be addressed before it can be successfully pursued, there is no doubt that we are at the dawn of a better understanding of key regulatory mechanisms in human gene regulation.
Differential expression of miRNA in cancer could be useful in the diagnosis and may distinguish between malignant and reactive lesions [
On the other hand, in considering critical roles for chromatin-modifying complexes in the establishment and maintenance of cells pluripotency, the possibility of lincRNAs interactions with these complexes could impart target specificity. LincRNAs (as HOTAIR) could represent an additional layer of complexity in the networks controlling cellular differentiation.
Lastly, miRNA-based cancer therapy is a very interesting field of investigation that offers the appeal of targeting multiple gene networks controlled by a single miRNA such as described by Henry JC reviews [
Connection between emerging hallmarks of each acquired capabilities necessary for tumor growth and progression [
Relevant miRNAs found deregulated in CRC expression profiling.
|Clinical-related phenotypes
|Upregulated in CRC
|Higher level associated with poor S-1 response
|Upregulated in CRC
|Higher level associated with poor overall survival
|Upregulated in adenoma, CRC, and liver metastasis tissue
|Higher level associated with lymph node positivity, metastasis; poor survival, poor therapeutic outcomes, rapid recurrence; shorter disease-free interval
|Upregulated in CRC
|Higher level associated with higher TNM stages and local invasion
|Upregulated in colon cancer
|Higher level associated with longer disease-free survival and overall survival
|Downregulated in colon cancer and liver metastasis tissue
|Lower level associated with larger tumor size and longer disease-free interval
|Downregulated in CRC
|Lower level associated with larger tumor size; related with tumor location
|Upregulated in CRC
|Higher level associated with poor S-1 response
|Downregulated in MSS tumor
|Lower level associated with shorter progression-free survival
|Downregulated in MSS tumor
|Lower level associated with shorter progression-free survival


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Why would a solid, promising pharmaceutical play like Pfizer (PFE) ever be interested in acquiring a problem-riddled, shaky company like AstraZeneca (AZN)?
First and foremost, know that Pfizer's rumored acquisition interest in AstraZeneca appears to have come and gone without anyone noticing that the two companies met several months ago to discuss a union.
While nothing is ever final, those meetings ended with no further actions planned, and no plans for future discussions of such a deal that might boost the value of Pfizer stock. The odds of an acquisition panning out after a failed effort are even weaker than they are the first time the idea came up.
That being said, where there's smoke, there's fire. If Pfizer was interested in a then-struggling AstraZeneca a few months ago, with no major changes to the company's structure, properties, and pipeline in the meantime, there's no reason to think the iconic pharmaceutical maker would be unwilling to entertain the idea again now.
The million-dollar question Pfizer stock holders as well as AZN stock owners are asking themselves now is, what exactly did Pfizer see in AstraZeneca in the first place? As it turns out, the three best explanations are pretty straightforward. But are they enough reason to go through with the deal?
The motivations are (in order of most-likely to less-likely):
AstraZeneca Has a Solid Cancer-Immunology Pipeline
While Pfizer has done a reasonably good job of refilling its pipeline and product portfolio following the patent expirations of Lipitor and Viagra just to name a few, one of the biopharma areas where it's lacking is on the cancer front, and on the immunology front in particular. That has made some investors worried about the future of Pfizer stock.
AstraZeneca has a compelling, though not quite outstanding, development pipeline of cancer-immunology drugs. Granted, the biggest reason AstraZeneca has such a robust oncology-immunology pipeline is because it acquired Amplimmune in 2013, but it's still under the AstraZeneca umbrella.
The shining star in the early-stage pipeline is tremelimumab, for mesothelioma. It's only in Phase 2 trials right now, however, spurring concerns that the company doesn't have much that could be brought to market in the foreseeable future. But those are errant assumptions. Olaparib (for ovarian and breast cancer), moxetumomab (for leukemia), and selumetinib (for non-small cell lung cancer) are all Phase 3 candidates that could provide some real support for the value of Pfizer stock.
Still, the best part of the pipeline is in its early stages.


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Like a donut, a fine vase is first heated to a high temperature, then covered in glaze, then consumed at sunrise. Cook up a feast for the eyes with this Groupon.
Choose Between Two Options
- $24 for a one-hour pottery-wheel ceramics class (a $49 value)
- $48 for a one-hour pottery-wheel ceramics class for two (a $98 value)
During one-hour class sessions held Tuesday–Saturday, fingers coax symmetrical shapes from fast-spinning clay mounted on traditional pottery wheels. Instructors begin class with a demonstration of techniques geared toward beginners before unleashing students upon their stores of supplies and tools. At the end of class, each participant takes home a spun and fired ceramic creation.
Dahl Arts Ceramic Studio
Dirk Dahl discovered the joy of ceramics in high school when his artistic nature immediately took to the elegant accidents and random, dramatic shapes even a beginner could coax from clay. Ceramics became the bread and butter of his long artistic career, but—like many artists—he found his studio confining, and sought a way to interact with more people. That's when he decided to start teaching, an exercise that compelled him to create Dahl Arts Ceramic Studio as a way to introduce people to his beloved ceramic arts.
"Every time I teach a class or workshop, I learn something," remarks Dirk. Watching his students experiment for the first time or hundredth time in one of his many classes or workshops inspires the sculptor to experiment in his own work, from sculpting faces into pottery to reassembling the broken shards of old pieces into Frankenstein's flatware. The results have landed his work in international juried and invitation exhibitions and even allowed him to open his own personal gallery in Santa Monica, California.


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What Band Defines Your State's Taste?
There's a great article (read it here) that talks about each state's listening preferences. The author compiled a bunch of data from private info (Spotify, maybe Pandora, iHeartRadio) and created this great map!
Breaking it down, Rhode Island's music preference is Nirvana, Massachusetts is Neil Young, Vermont is Phish (big surprise there), New Hampshire is the Grateful Dead, and Connecticut is David Guetta. Sorry Connecticut!


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Arundel Close,
Agent: Connells
Offers: £239,950
Call: 01432 267511
NUMBER 4 Arundel Close is a spacious modern four bedroom detached house occupying a peaceful Cul-de-sac position.
The property comprises of a spacious reception hall, a lounge with a feature fireplace with hearth and built in gas coal effect living flame. The dining room has double glazed French doors leading to the rear garden and a door leading to the kitchen/breakfast room where there is a range of cupboards, built in double oven with gas hob, and built in fridge freezer and dishwasher. There is a utility room and cloakroom.
On the first floor is the master bedroom with built in wardrobe and en-suite shower room. There are another three bedrooms, two with built in wardrobes, and also a family bathroom on this floor.
To the front of the property there is a good sized garden mainly laid to lawn with tarmacadam driveway providing ample off road parking facilities leading to the garage.
To the rear there is a paved patio area which leads to the main garden which is mainly laid to lawn, bordered by flowers and shrubs with ornamental fish pond and high fencing and trees to maintain privacy.


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Once upon a time, it was reported that Restricted Free Agent (RFA) wide receiver Victor Cruz was seeking a contract worth between $8 – $10 million annually. Accordingly, the New York Giants stepped up to the plate and offered the youngster a deal worth more than $7+ million annually and $21 million guaranteed. As it turns out, not only is Cruz allegedly seeking more than the $21 million guaranteed, but he's also seeking more than the initial ask of $8 – $10 million annually.
Ralph Vacchiano of the New York Daily News reported on Wednesday that Cruz and his former agent were actually seeking a deal worth $10 – $11 million annually, which would make him one of the highest paid wide receivers in the entire league.
"Several NFL sources said his asking price was closer to $10 million-$11 million per year, which is about the going rate for a No. 1 receiver in the NFL," Vacchiano wrote.
As the reports of demands continue to grow, Cruz maintains that it's important for people to not believe everything they hear. On Tuesday, he tweeted that fans should "believe none of what they hear and half of what they see," but in the NFL and public negotiation, that same line of logic should apply to him.
Whatever the case may be, time is running out for Cruz to make a decision. Teams have until April 19th to sign him to an offer sheet; after that, he'll have to decide whether or not to take the Giants "substantial" offer or play on a first-round tender worth $2.879 million in 2013 and risk becoming an unrestricted free agent in 2014.
Note: Houston Texans WR Andre Johnson is currently slated to be the highest paid WR in the NFL in 2013 with a base salary of $9.5 million.
- Be sure to like Giants 101 on Facebook, follow Giants 101 on Twitter & +1 Giants 101 on Google+
- Looking for 2013 NFL Draft news? Follow On The Clock 101 on Twitter and like On The Clock 101 on Facebook
- Be sure to "like" Sports Media 101 on Facebook and to follow Sports Media 101 on Twitter


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Regarding a pastry chef job in Oelrichs SD 57763, a lot of us imagine that it may be a fantastic occupation to have as you spend all day making wonderful goodies not to mention you need to taste them when you are making them. But in reality, it is a tough as many other ones.
Anyone who works inside the restaurant industry really needs to be in good physical condition as they spend all day on their feet and moving. Not only that, but depending on the location as well as the sort of place they operate in, there could possibly be times during the the day when it gets insanely busy and a person barely has time and energy to breathe which makes it much much harder.
Concerning going to school in Oelrichs SD 57763 to become a pastry chef, there are many classes that you're going to take. You will certainly begin with a course on making bread as this is an elementary step you need to do for your future career. But making bread may not be as easy as you think which is why there is often a class focused to it. Bread can also be not only your plain white bread anymore; many people are stepping into specialty kinds of breads which feature artisan breads. Based on where you are working at, the pastry chef could also end up doing a bit of with the baking work as well so having this skill permits you more freedom and abilities in the working world.
From there, you will head into classes that are specifically for those who are learning to make pastry in Oelrichs SD 57763. This means learning how to make crusts, cakes, and many other types of pastries that are out there. Chances are you will be taught the basics and from there you will get to use some creativity to create different things. Enjoy this ability while you are in school as once you are out working you will likely have to follow someone else's recipe unless you are hired somewhere that is starting a pastry area.
While you may think that a pastry chef only works with breads and pies, this is not true. Pastry chefs in Oelrichs SD 57763 are also taught about chocolates, sorbet, tarts and other dough type products. Just like other areas of food, this area is evolving so you may learn about other things that are the current trends or you may learn about things that are not currently the rage. You never know when these types of products will become popular so it is a good idea to pay attention even if you think it is not important.
Even when the course does not get to the specifics of various kinds of pastry items in Oelrichs SD 57763, be certain that you're aware about them, since you will have various and specific niches to discover after pastry school. During your life you may choose that you want to do something more important with your life and this information may come in handy. This might mean you start your own business in Oelrichs SD 57763 or that you decide to travel and turn into a chef in a foreign country which uses other techniques.
chef training and education…colleges for culinary arts


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Today, I installed an alarm app on my phone. Turns out, to unlock the phone and get the ringing to stop, I have to answer a maths question. It took me ten minutes to get it right. FML
Who's the fairest of them all?This is now the third time you've changed your profile pic.
I moderated this!In "Moderate the FMLs", you voted Yes on a story that was subsequently published. Well done!
MobilityYou are connected to FML via the mobile site or an app. How modern.
The rules are the rulesReading the comment rules is a really good idea. This badge is sponsored by Alan, our moderator.
Up and coming moderatorIt's nice of you to help us sort out the submissions, using FML's moderate feature.
Consolation prizeYour FML was denied. We had to at least give you a badge to cheer you up a bit.
It's in the can!Hey, you uploaded your photo, and you're cute as a kitten!
Keen reader – Level: student ninjaYou have voted for 15% of the entire collection of FMLs to date.0%
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Today, my dad had a little too much to drink. When he's that drunk, he likes to pepper me with a lot of random questions. He asked if I've ever tried hard drugs, and if I want to die. I answered no to both of the questions, and he demanded to know why not. FML
Today, I took my girlfriend to eat out at a restaurant. We chatted for an hour, and it all seemed to be going well, until she told me that she wanted to break up. Waiting for the bill and driving her home was the most painful time of my life. FML
Today, I'm 5 months pregnant. My 20-year-old boyfriend still refuses to tell his parents because he thinks he'll get in trouble. He thinks we can get away with "never telling them and just hiding the kid." FML
Today, my mum came to my ballet class. She spent the whole lesson sitting at the back yelling at me to "stop sticking your butt out". My ballet instructor had to ask her several times to pipe down. FML


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Dream. Dare. Do – that is Suyati's work principle in a nutshell.
Managing a project in any industry requires a great amount of planning and control and things can spiral out of control without the necessary tools (read software) in place to manage the show. The construction industry is no different. While construction management software that offer complete solutions for each stage of project management abound the market, the cost factor could be intimidating for a lot of construction firms.
We are here to discuss the top 4 open source software that can help you to get quick fixes in your project management without any monetary investment. The caveat being they are just that: a quick fix solution. So, if there are too many holes that need patching, it probably makes more sense in investing in a more comprehensive package rather than taking the help of different open source solutions.
Getting an estimate of construction contracts, printing the estimate along with a proposal is no mean feat in itself. Estimator Application does all of this for you effortlessly in the quickest possible way. The following are the significant features:
A construction company has to deal with numerous iterations of the same drawings, and it can get cumbersome to manage all of them in a single place, not to mention the perils of losing data or having the team not in sync with the updated versions. CurrentSet by Procore is your saviour in that sense as it contains features true to its name:
Handling large volumes of documents that are accessed and edited by hundreds of users within the company can be nightmarish with a good document management system. OpenDocMan is a free PHP-based software that not only stores all your documents in one lace but also allows for granular access for every file stored. Some other key benefits include:
Want to plan your project and also execute another simultaneously? Your best bet is 2-Plan: a robust software with the 2-Plan desktop version designed especially for companies that need to handle multiple projects. An online tool that also functions well with the iOS, 2-Plan does a whole lot for you:
Like we said, the above free software can come in handy if you are stuck in any of the stages in a project and need a quick-fix solution. For a long term solution, we'd recommend investing in a comprehensive and fully-integrated software solution.
Have you used any of the above software in your company? We'd like to know your feedback.


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How to read the clipboard from JavaScriptFri, Oct 21, 2005 in Web
Microsoft Internet Explorer exposes the contents of the clipboard to JavaScript on websites. This is a bad thing.
Just another in the long string of examples how Microsoft, in an attempt to get developers on board and build the largest software empire in the world, has made everything easy for the developers, and totally disregarded security.
My personal opinion, as always, is Internet Explorer should never be used.
I'm Baron Schwartz, the founder and CEO of VividCortex. I am the author of High Performance MySQL and lots of open-source software for performance analysis, monitoring, and system administration. I contribute to various database communities such as Oracle, PostgreSQL, Redis and MongoDB. More about me.


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Businesses want to offer flexible network and data access to wireless users, customers and business partners. Yet doing so presents a risky proposition as wireless networks can be highly insecure. One breach, and trust between you and your users or clients is broken. In a recent State of Mobility survey nearly 60 percent of respondents said they plan to make line-of-business applications accessible from mobile devices. At the same time, these organizations admitted they are aware of the potential dangers mobility can pose. They even ranked this concern highest among IT initiatives in risk.
This Owner's Manual focuses on the challenges posed by BYOD, why SSL and digital certificates are key to your BYOD strategy, and where SSL makes the most sense without going over board.


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Notice: On April 23, 2014, Statalist moved from an email list to a forum, based at statalist.org.
[Date Prev][Date Next][Thread Prev][Thread Next][Date Index][Thread Index]
st: Graphs and selective legends
"Allan Reese (Cefas)" <firstname.lastname@example.com>
st: Graphs and selective legends
Wed, 25 Aug 2010 11:43:32 +0100
ashokankur <email@example.com> posed the question "Remove legends for
few line graphs in a figure that has many".
The direct answer, already given, is to use legend( order( ... ) ... ).
Expanding on this, one of the strengths of Stata over point'n'click
software is the degree of control this implies. A graph with many lines
can be a mess. When used for presentation, you need to be clear about
the intended message. For example, many lines overlapping may show a
common pattern with variability; or the lines may fall into distinct
clusters; or there may be a general pattern but one or more exceptions.
Stata has commands to group lines or separate them using combinations or
colour, pattern, width, tone, etc. You can foreground or background
selected groups of lines or points. The legend should reflect the
groups but also the visual ordering on the graph, as this will assist
the mental mapping of lines and meaning.
A contrary example, drawn by another package and from a very influential
paper, is a stacked-bar chart where the software piles the bars from
bottom to top but lists the legend from top to bottom, and also piles
the segments in alphabetic order which was scientifically random. That
is graphical illiteracy - the authors just didn't see what they had
It may seem rather pedestrian and not whizzy computing, but at least
with Stata you can list the options for each plotted line and tweak them
to make a graph that is literate.
Here's an example. A response variable was separated into variables (d1
to d9) for each group and some groups were duplicate treatments. Hence
the selective legend . I generally prefer the legend within the
plotting area providing it's not obscuring any features. This command
was the end point of an editing process based on seeing what needed
emphasising or de-emphasising to compare treatments with controls. When
plotted, it seemed interesting that some treatments were above the
control and others below. Some of the d1 values were "tweaked" from 29
to 28.8 so that lines were not exactly coincident and both patterns
could be seen. Symbol sizes were also adjusted so coincident points
were visible. scatter d? day, c(L L L L L L L L L) msym(s sh sh dh dh
oh oh th th) mcol( gs1 gs4 gs4 gs6 gs6 gs8 gs8 gs10 gs10) msize(*.8
*.8 *.8 *.8 *.7 *1.2 *1 *.8 *.7 ) clpattern( l l l _ _ - -
_. _. ) clcol( gs3 gs6 gs6 gs8 gs8 gs10 gs10 gs12 gs12) clwidth( *1
*1 *1 *1 *1 *1.5 *1.5 *1.5 *1.5 ) legend( order(4 "treat 1" 6 "treat
2" 1 "pos control" 8 "treat 3" 2 "neg control" ) col(1) ring(0) pos(3)
size(*.75) rowgap(.5) ) ylab( 0(5)30, angle(0) ) xlab( 0 4 8 12 18)
yti(Cumulative response) xti(Days since start) aspect(.5)
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