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S$65 million redevelopment plan proposed.
The Board of Directors of Raffles Medical Group Ltd wishes to announce that Asian HealthCare Capital Management Pte. Ltd. (AHCM), a wholly-owned subsidiary of RMG Capital Pte. Ltd., which in turn is wholly-owned by the Company, has on 13 December 2013 entered into a sale and purchase agreement (SPA) with DBS Bank Ltd. (DBS Bank) to acquire the property at 100 Taman Warna, Singapore 276405 for the purchase consideration of S$54.8 million.
The Purchase Consideration was arrived at on a "willing-buyer and willing-seller" basis, after taking into account current market prices of properties in the vicinity and an assessment of the Property's redevelopment potential.
A deposit of S$5.48 million, being ten per cent (10%) of the Purchase Consideration, has already been paid by the Company to DBS's solicitors on 13 December 2013. The balance of the Purchase Consideration will be paid on completion, which is expected to take place on 29 January 2014.
The Purchase Consideration will be satisfied in cash, and funded by a combination of internal resources and bank borrowings.
The Directors believe that the Acquisition is a strategic opportunity for the Company to expand its core business of providing healthcare and medical services. The Property is situated at an attractive location and will provide a good catchment of local and expatriate patients. The Property has a land area of 1,942.3 square meters, and is located at the junction of Taman Warna and Holland Avenue, within the Holland Village residential, shopping, and food and beverage belt. The Property is adjacent to Holland Village MRT Station.
The Property sits on 99-year leasehold land, of which 72 years of tenure remains.
The Company intends to redevelop the Property, through AHCM, into a 5-storey commercial building comprising five (5) above-ground levels, one (1) basement level, and two (2) levels of basement car parks. The proposed Redevelopment will achieve a gross plot ratio of 3.00, which represents a floor area of 62,720 square feet.
Following its Redevelopment, the Company intends to lease approximately 9,000 square feet of space on the first and fifth levels of the Property, for use as outpatient medical and specialist clinics. Additionally, pursuant to the SPA, DBS Bank shall lease 4,500 square feet of space on the first and second levels of the Property for its banking operations. The Company intends to lease out the remaining leasable areas of the Property to retail shops and food and beverage outlets.
It is estimated that the cost of Redevelopment, which comprises, inter alia, construction costs, development premium, stamp duty, property tax and interest expenses, will amount to approximately S$65 million.
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Alright…confession time: Shen was the last time you changed the air filter in your home? Is this your job? Or does someone else do this in your home?
I recently had someone come and look inside our air vents to see if they needed to be cleaned. They were not that dirty…probably a 5 on a scale of 1 to 10. In talking with the guy, I learned a few things that I can do to keep the air filter doing it's job well. Since it's winter and most of us are indoors a lot, I thought we all could use a good reminder.
Here are the tips:
– Write the date on the air filter so that you know exactly when you put it in and then you can best figure out how often to change it. Most of the nicer home air filters have a spot where you can write the date, but try writing the date on the edge where you can see it without having to pull it all the way out.
– Learn which way the air flows through your furnace so that you put the air filter in the right way. The air filter has arrows on it so that you can know which way it should go in. Also write an arrow on your actual air unit/furnace so that you know which way to put the filter in.
– Write the size of filter needed for your unit on your unit, so that you know exactly what size you need and you don't have to guess. Also keep a note on your phone of the size you need so that you can pick up some extras at the store when you are out.
– Spend the extra money on the nice ones. The more accordion folds you see the nicer. If it's completely flat, it will be easier for debris to get through it.
– Change it often…once a month, depending on what type your home has. If it's not that dirty, or if the type of filter you use is really expensive, you could always just vacuum it to keep it clean in between changes.
We've lived in our home for almost 9 years, and I don't think my husband has ever changed the filter once in those nine years. It's funny because it hasn't ever been something we have talked about, it's just something that I keep up on, which I don't mind. Keeping your air filter clean and new can save you a lot of money not only in the cost of your heating bill, because your system doesn't have to work as hard, but also it can prevent unwanted repairs too.
Now it's your turn. Is your air filter bad right now? Are you the one to keep up on it?
*For more craft tutorials, great recipes, free printables, fun giveaways, and real life you can follow Kami at NoBiggie.net, or find her on Facebook, Pinterest and Twitter.

subset: commoncrawl


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Major League Ultimate Season Ticket account holders are subject to the Ticket Policy and Stadium Rules of Conduct:
Printed tickets remain the property of Major League Ultimate (MLU) and are a revocable license which may be withdrawn and admission refused anytime upon refunding the printed purchase price. Season ticket account holders are responsible for the actions of themselves and any individual(s) using their seats. Major League Ultimate reserves the right to terminate the season ticket account in its entirety if the account holder or any individual using the seats engages in disorderly conduct or otherwise fails to follow facility rules and regulations. In such case no refund shall be made of any amounts paid for such season tickets and season ticket holder waives its right to any such refund. Resale or attempted resale of tickets is grounds for seizure and cancellation. The holder agrees not to engage in transmitting any description or picture of this event. This ticket may not be used for advertising, promotional or other trade purposes without the express written consent of Major League Ultimate. The holder grants permission to Major League Ultimate and its agents to utilize or grant to any other party the right to utilize the holder's image, likeness or voice in connection with any broadcast, photograph or any other reproduction in whole or in part of this event via any media and for any purpose in perpetuity. SPECTATORS VOLUNTARILY ASSUME ALL RISK AND DANGER OF PERSONAL INJURY (INCLUDING DEATH) AND ALL OTHER HAZARDS ARISING FROM OR RELATED IN ANY WAY TO THIS EVENT.
Ticket Policy for Children:
Children under the age of (2) years do not need a ticket to enter a Major League Ultimate game. They must be seated on a parent or guardian's lap.
Season ticket holders will have access to the five (5) regular season MLU games of the team for which the tickets are purchased (herein "home team"). Season ticket holders will have first right of refusal for any additional home matches of that same team (including MLU Playoffs and exhibition matches) and will also receive pre-sale opportunities for the MLU Championship.
Major League Ultimate currently accept Visa, MasterCard, Discover, and American Express. Cash payments are also accepted at the box office.
Discounted group tickets can only be purchased through the Vancouver Nighthawks front office by emailing firstname.lastname@example.com
If you are interested in attending an away game for the Nighthawks, you will need to purchase tickets through the away teams website or at MLUltimate.com.
If a game is cancelled or rescheduled, information is immediately posted on www.vancouvernighthawks.com and emailed to those on the mailing list. Please be aware that there is no way to contact all individual ticket holders other than our website and email. If a game is cancelled, refunds will automatically be provided in the form of ticket credit. If the event is rescheduled, tickets purchased for the original date will be honored on the new date. Cancelled Event – A cancelled event is one that will NOT be made up. Postponed or Rescheduled Event – A postponed or rescheduled event is one that WILL be made up at a later date.


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As The Floozies are about embark on their Fantastic Love Fall Tour, the electronic-funk duo just announced yet another action-packed slew of dates for their Do Your Thing Winter Tour.
Although the Midwest festival season grows closer to an inevitable end, there are still a plethora of different festivals waiting for their moment to shine. Next weekend, festivalgoers will descend upon the beautiful rolling hills of Northwestern Wisconsin for the third annual Summer Set Music Festival held in Somerset, WI.
Memorial Day weekend always produces a number of different and distinct music festivals across the country, however one Midwest festival in particular has proved for countless years that they know how to throw a unique concert experience complete with a diverse music selection, an enthusiastic and experienced crowd, and a little help from the weather gods.
When the threat of 50 MPH winds and impending heavy rain don't get you down - you know you're in the right place. And for a lot of people, that place was Wakarusa on Friday. Luckily, the 50 MPH winds passed us by, but our day did start off with a pretty heavy amount of rain. We're used to that by now, though.
I want to start by emphasizing the importance of keeping an open mind always, but especially when listening to and choosing live music to see. Throughout all of my years of seeing a lot of live music, I have always listened before I judged, and it has afforded me the ability to discover bands and performers that I would have never known about.
Purple Hatter's Ball has added several new artists to the line-up including: Colorado's dance-funk seven-piece The Motet; electronic producer/guitar player and drummer duo, The Floozies who are performing at Spirit of the Suwannee Music Park for their first time; the infectious soul-funk of The Fritz; and the inspiring soulful sounds of Avis Berry & Scott Campbell Band, as well as Yankee Slicker
The Floozies and TheUntz.com have announced dates for their 2014 winter tour.
The Floozies are excited to release their first full length studio album, Tell Your Mother, on November 5th. Tell Your Mother will be the inaugural album released off of
Spring is right around the corner and for many excited festival attendees the anticipation is building for the annual Summer Camp Music Festival, held at Three Sisters Park in Chillicothe, Illinois.
What's better than being a rising star in a diverse genre that seems to know no boundaries? How about having a like-minded, equally talented brother to help mastermind the operation. Just ask The Floozies, the hottest new electronic duo hailing from Lawrence, Kansas.
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Portugal Telecom has strengthened the coverage of its 4G network, which allows about 80 percent of the Portuguese benefit from a new mobile Internet experience. This became possible following the termination of television analogue terrestrial system, which took place on April 26, freeing the frequency band of 800 MHz, in which PT acquired rights to use frequencies in the following the auction multitrack. The increased coverage will be significant (up to now stood at 20%) highlighting the quality of buildings and places in PT among the first operators at European level to provide 4G services in the frequency of 800MHz.
With the extension of coverage of the 4G network, the TMN and Meo 4G. 4G will benefit from greater speed, lower latency and better quality of experience. Together with the fiber optic network of PT, which reaches 1.6 million homes, these features enhance the supply of new multimedia services, mobility, until now only possible through fiber optics, especially television, gaming services online and mobile broadband access with speeds up to 100 Mbps. PT offers two offers TMN 4G and 4G MEO diverse aspects that favor the use of the Mobile Broadband service, leveraging the potential of other existing offerings, such as the Meo and Musicbox This Go way, customers can access TMN and Meo transversely to an offer converged voice, video and Internet on multiple devices, with a quality experience and superior service and the most advanced in the world. The 4G network in PT was recently recognized by manufacturers as a reference for operators in Europe to present the first European network qualified by the GCF (Global Certification Forum), the mechanism CSFB (Circuit Switch Back Fall), which allows voice communication 4G networks. This support, required to provide voice service for 4G smartphones, reinforces the status of the operator in terms of quality, reliability and robustness of its network of cutting edge technology.
Source: Wireless Federation.
© Copyright 2017, ITU
The information presented within this blog comes from various organizations around the world. ITU encourages users to seek more detailed information from the original source through the links provided.
Links to third-party websites are provided for the convenience of all users. The ITU is not responsible for the accuracy, currency or the reliability of the content on these third-party websites. ITU does not offer any guarantee in that regard nor does ITU endorse the third-party organizations, their sites or content.


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|I throw an object, then other machines will wait for it... And catch!!!
|Wow wow wow TheIdeasMan!!! I like this stack feature!!!
I'll try this XDXD TheIdeasMan@!!
That's it, the stack problem has been solved, only parsing process (Reading and parsing a file and do everything if possible) Now I realized that programming are only calculations and calculations, and no anything else... ) Great!!!
Oh... I like this!!! Now, I'm totally ready XDXD !!! Making an interpreter is very easy, but it.. takes time... Certainly, it's always.. true.
Stack? Yes. It's the most important primary thing 100%!!! I throw an object, then other machines will wait for it... And catch!!!
|I think I should make a tree stack structure...
|x = 5 + 2 * 8
|Some friendly advice (In Jest of course): Anyone who thinks I am a woman (or refers to me as such) should come down here to find out in person. Upon arriving they will see it is not a good idea to eff with me. :D
|Am I the only one who sees this as cyber-threatening?
|Tim wouldn't threaten anyone!
|"TheIdeasMan and Jackson Marie in a red-black tree,
|But, I'm afraid of posting some code example demonstration here because... I think...


text:
2011 TOYOTA Camry LE Sedan 4D
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2011 TOYOTA Camry LE Sedan 4D
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Gets 28+ MPG Hwy.
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Glen Carbon, IL 62034-3224
- Power Seat
- AM/FM Stereo
- Dual Air Bags
- ABS (4-Wheel)
- Daytime Running Lights
- Steel Wheels
- Tilt Wheel
- Head Curtain Air Bags
- Keyless Entry
- Cruise Control
- Traction Control
- Power Windows
- Power Steering
- MP3 (Single Disc)
- Power Door Locks
- Air Conditioning
- Side Air Bags
- Stability Control
- Metallic interior trim -inc: chrome door handle accents
- Pwr auto door locks w/anti-lockout feature
- Engine immobilizer
- Dual visor vanity mirrors
- Front & rear map pockets
- Remote keyless entry -inc: trunk release panic feature
- Front bucket seats -inc: driver height adjuster driver lumbar support
- 60/40 split-folding locking rear seat
- Adjustable front & rear headrests
- Pwr windows -inc: auto up/down retained pwr pinch protection
- Tilt/telescoping steering wheel -inc: audio controls
- Lockable illuminated glove box
- Bi-level center console w/storage
- Overhead console -inc: front map lights sunglass holder
- Remote trunk & fuel door releases
- Trunk luggage box
- Air conditioning -inc: dust & pollen filter
- Fabric seat & door trim
- (2) 12V aux pwr outlets
- HD electric rear window defogger w/timer
- Cruise control
- Fold-down rear center armrest w/dual cup holders
- Multi-adjustable pwr driver seat
- Illuminated entry
- In-glass antenna
- Optitron gauges -inc: twin tripmeters outside temp display
- Compact spare tire
- 16 steel wheels -inc: full wheel covers
- High solar energy-absorbing glass
- Auto on/off halogen headlamps
- Color-keyed pwr mirrors
- Washer-linked variable intermittent windshield wipers -inc: mist cycle
- P215/60R16 all-season tires
- Internal trunk release handle
- Daytime running lamps
- Direct tire pressure monitor system
- Driver & front passenger advanced airbags -inc: occupant sensor
- LATCH child restraint system *Outboard Rear Seat Positions Only*
- Front & rear side curtain airbags
- Child-protector rear door locks
- 4-wheel anti-lock brake system -inc: electronic brake-force distribution
- Driver & front passenger seat-mounted side airbags
- Driver knee airbag
- Traction control
- Vehicle stability control -inc: off switch
- Variable assist pwr rack & pinion steering
- Front/rear stabilizer bars
- Pwr front ventilated/rear solid disc brakes -inc: brake assist
- Independent MacPherson strut front suspension -inc: gas shocks
- Front wheel drive
- Battery saver feature
- 2.5L 4-cyl engine w/VVT-i
- Independent dual-link rear suspension -inc: gas shocks
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Elton John and other fans pour out emotion
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Elton John tracked down Kylie Minogue's personal phone number in Australia to give her his best wishes "on behalf of Great Britain", according to London's Evening Standard newspaper.
The website of BBC's Radio One was flooded with fans' messages of good wishes for the singer, who has cancelled her headline act at Glastonbury, Britain's largest music festival, next month. More than 70 messages were posted on the BBC website in about an hour last night. Fans from as far afield as India, Ghana, the US and Serbia sent their best wishes.
Among the messages, Sarah Hart wrote: "I just want to wish the Pop Princess the best of luck - she's my idol and I've grown up with her. It makes you realise things like this can happen to anyone and that fame and fortune can't buy you everything. She's such a fantastic person and I hope all goes well."
And Jules wrote: "Wishing you a safe and quick recovery Kylie. I am not a pop fan but purchased your double CD solely for the song Red Blooded Woman has bought the lighter side of music to my iPod. Thinking of you. X."
Minogue's own website, www.kylie.com, had several pages of comments from fans within hours of the news.
"I have been searching for the right words all morning but still it leaves me choked to believe such a sad thing has happened to one of the best persons in the world," British fan Ian Taylor wrote.
Another fan, signing himself 'mainframe', wrote: "I have had arthritis since I was born and I have always been happy because of your songs.
"If you would like me to sing to return the favour, just send me an email."
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text:
Document Type
- Article (3)
- Part of a Book (1)
- Attribution and detection of anthropogenic climate change using a backpropagation neural network (2002)
- Simulation of global temperature variations and signal detection studies using neural networks (1998)
- The concept of neural network models (NNM) is a statistical strategy which can be used if a superposition of any forcing mechanisms leads to any effects and if a sufficient related observational data base is available. In comparison to multiple regression analysis (MRA), the main advantages are that NNM is an appropriate tool also in the case of non-linear cause-effect relations and that interactions of the forcing mechanisms are allowed. In comparison to more sophisticated methods like general circulation models (GCM), the main advantage is that details of the physical background like feedbacks can be unknown. Neural networks learn from observations which reflect feedbacks implicitly. The disadvantage, of course, is that the physical background is neglected. In addition, the results prove to be sensitively dependent from the network architecture like the number of hidden neurons or the initialisation of learning parameters. We used a supervised backpropagation network (BPN) with three neuron layers, an unsupervised Kohonen network (KHN) and a combination of both called counterpropagation network (CPN). These concepts are tested in respect to their ability to simulate the observed global as well as hemispheric mean surface air temperature annual variations 1874 - 1993 if parameter time series of the following forcing mechanisms are incorporated : equivalent CO2 concentrations, tropospheric sulfate aerosol concentrations (both anthropogenic), volcanism, solar activity, and ENSO (all natural). It arises that in this way up to 83% of the observed temperature variance can be explained, significantly more than by MRA. The implication of the North Atlantic Oscillation does not improve these results. On a global average, the greenhouse gas (GHG) signal so far is assessed to be 0.9 - 1.3 K (warming), the sulfate signal 0.2 - 0.4 K (cooling), results which are in close similarity to the GCM findings published in the recent IPCC Report. The related signals of the natural forcing mechanisms considered cover amplitudes of 0.1 - 0.3 K. Our best NNM estimate of the GHG doubling signal amounts to 2.1K, equilibrium, or 1.7 K, transient, respectively.
- Nonlinear statistical attribution and detection of anthropogenic climate change using a simulated annealing algorithm (2003)
- The climate system can be regarded as a dynamic nonlinear system. Thus, traditional linear statistical methods fail to model the nonlinearities of such a system. These nonlinearities render it necessary to find alternative statistical techniques. Since artificial neural network models (NNM) represent such a nonlinear statistical method their use in analyzing the climate system has been studied for a couple of years now. Most authors use the standard Backpropagation Network (BPN) for their investigations, although this specific model architecture carries a certain risk of over-/underfitting. Here we use the so called Cauchy Machine (CM) with an implemented Fast Simulated Annealing schedule (FSA) (Szu, 1986) for the purpose of attributing and detecting anthropogenic climate change instead. Under certain conditions the CM-FSA guarantees to find the global minimum of a yet undefined cost function (Geman and Geman, 1986). In addition to potential anthropogenic influences on climate (greenhouse gases (GHG), sulphur dioxide (SO2)) natural influences on near surface air temperature (variations of solar activity, explosive volcanism and the El Nino = Southern Oscillation phenomenon) serve as model inputs. The simulations are carried out on different spatial scales: global and area weighted averages. In addition, a multiple linear regression analysis serves as a linear reference. It is shown that the adaptive nonlinear CM-FSA algorithm captures the dynamics of the climate system to a great extent. However, free parameters of this specific network architecture have to be optimized subjectively. The quality of the simulations obtained by the CM-FSA algorithm exceeds the results of a multiple linear regression model; the simulation quality on the global scale amounts up to 81% explained variance. Furthermore the combined anthropogenic effect corresponds to the observed increase in temperature Jones et al. (1994), updated by Jones (1999a), for the examined period 1856–1998 on all investigated scales. In accordance to recent findings of physical climate models, the CM-FSA succeeds with the detection of anthropogenic induced climate change on a high significance level. Thus, the CMFSA algorithm can be regarded as a suitable nonlinear statistical tool for modeling and diagnosing the climate system.


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The race to the top of the Four Rivers Conference girls basketball standings got a lot more interesting Thursday night.
Sullivan became the final team to drop a conference game, suffering a 50-48 home setback to Pacific.
The Lady Eagles (18-3) have lost just three games this season, two of which have come against Pacific.
"Sullivan played 10 times better (Thursday) than they did the first time we played them. It was a crazy game," said Pacific Head Coach Josh Spuhl. "Playing there and winning was a great accomplishment for our team."
FRC Race
Hermann's 40-33 victory Thursday over New Haven means the Lady Bearcats (19-4) and the Lady Eagles stand in a first-place tie in the FRC standings with 4-1 records.
Union (14-6, 3-1) can join the top group with a win Friday at Owensville.
Pacific (16-4) and St. James (20-2) both are still alive in the hunt for the FRC crown, both sporting 3-2 records.
Needless to say, it should be a wild final week of FRC action next week.
Monday's FRC games are Union at Sullivan, Pacific at Hermann, St. James at Owensville and New Haven at St. Clair.
Thursday's games are Sullivan at St. James, Hermann at Union, St. Clair at Pacific and Owensville at New Haven.
"Our conference is insane. At the beginning of the year, most coaches thought it would be this way," Spuhl said. "If we can beat Hermann and St. James defeats Sullivan, we could have a four-way tie for first place with all four teams with two losses. Union also has a chance. We also play Tuesday against Eureka in a nonconference game, a team that took Parkway South to double overtime. It's never been our top goal to win the conference. The thing we focus on is getting better for districts. Hopefully we'll play well in our final two conference games and see what happens from there."
Like the last meeting between the two teams in the semifinals of the Lindbergh Tournament, Pacific started fast against Sullivan.
The Lady Indians jumped to a 14-6 lead in the opening minutes and led 16-11 after one quarter.
Sullivan chipped away in the second and third quarters, cutting Pacific's leads to 26-23 at halftime and 37-36 after three quarters.
"It was an intense game," Spuhl said. "We had an eight-point lead three or four times throughout the game. They got back in the game."
There was plenty of drama in the fourth quarter.
The game was tied 41-41 with 5:35 left, 43-43 with 4:18 remaining and 46-46 with 2:41 to go.
A free throw put the Lady Eagles ahead 47-46 with 1:03 left on the clock.
Pacific's Ellen Rogers forced a steal in the final seconds and the Lady Indians made free throws down the stretch.
With Pacific leading 50-47, Sullivan was fouled on a long three-point shot with 1.8 seconds left, sending it to the foul line for three shots and a chance to tie. The first free throw was missed and the second was made. The third shot was missed on purpose in hopes of an offensive rebound, but Pacific's Kya Hill grabbed the rebound tho secure the win.
"This was a game that we did not play very well, but we did give ourselves a chance to win at the end," said Sullivan Head Coach Jason Merkel. "When you shoot below 50 percent from the free-throw line and cannot come up with timely stops on defense, you're not going to win many close games. We were our own worst enemy."
It also was a huge win for Pacific, considering the seed meeting for the Class 4 District 9 Tournament is Saturday.
Lizzy Almo led a balanced scoring attack for Pacific 12 points.
Kya Hill and Hunter Kelemen both finished the game with eight points.
Ellen Rogers netted seven points, going 4-4 from the free-throw line.
Ashley Hill and Abby Spuhl both scored six points. Hill was 4-4 from the foul line.
Meagan Wakefield collected three points.
"It was good to have some balanced scoring," Spuhl said. "Sullivan did a great job making things hard on Kya."
Sullivan also had a balanced scoring attack, led by Taylor Lucas' 13 points. She was 3-3 from the foul line.
Sierra Pryor finished the game with 11 points.
Aley Lucas pitched in with seven points.
Heinle and Kaitlynn Hill both scored seven points. Megan Brandt had one point.
Pacific was 17-20 from the free-throw line. Sullivan was 10-19.
"We made 17 of our first 18 free-throw attempts," Spuhl. "We missed a couple at the end of the game."


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This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
Cereal crops such as wheat, rice and barley underpin the staple diet for human consumption globally. A multitude of threats to stable and secure yields of these crops exist including from losses caused by pathogens, particularly fungal. Plants have evolved complex mechanisms to resist pathogens including programmed cell death responses, the release of pathogenicity-related proteins and oxidative bursts. Another such mechanism is the synthesis and release of secondary metabolites toxic to potential pathogens. Several classes of these compounds have been identified and their anti-fungal properties demonstrated. However the lack of suitable analytical techniques has hampered the progress of identifying and exploiting more of these novel metabolites. In this review, we summarise the role of the secondary metabolites in cereal crop diseases and briefly touch on the analytical techniques that hold the key to unlocking their potential in reducing yield losses.
Eight major cereal crops including wheat, rice, barley, oat, rye, corn, sorghum and millet make up two-thirds of the worlds food supply [
Taking into account the vast number of potential plant pathogens that exist, the actual amount of disease is relatively small. This is attributable to an intricate array of defence mechanisms plants have evolved over time as a necessity to survive their immobile nature. Typically, disease is avoided when a host plant recognises the presence of a pathogen. This recognition activates various plant defence responses including phytoalexin production, primary metabolite signalling, production of reactive oxygen species, protease and chitinase production, cross-linking of cell wall polymers, production of pathogenesis related (PR) proteins and the hypersensitive response, which leads to localised cell death [
Plants synthesise a diverse range of secondary metabolites active in defence against a wide variety of pathogens [
In recent years, substantial advances have been made in discovering and characterising secondary metabolites from both plant and animal sources. Significant technological advancements in high throughput and mass spectrometry (MS) have evolved a new research discipline called metabolomics -the study of small molecules in biological systems. A number of techniques are used for high throughput analysis of an extensive range of structurally and chemically diverse metabolites. Gas Chromatography-Mass Spectrometry (GC-MS) is utilised for analysis of polar metabolites following chemical derivatisation and volatiles using headspace analysis. Liquid Chromatography-Mass Spectrometry (LC-MS) is capable of analysing a range of polar and semi-polar compounds for which no chemical derivatisation is required. Nuclear Magnetic Resonance (NMR) Spectroscopy and Fourier Transform Infrared (FTIR) Spectroscopy are also utilised to structurally characterise small molecules however due to a combination of cost and complexity of the resulting data they are not as common as GC and LC-MS. These techniques enable identification and quantification of metabolites, which through carefully designed biological experiments, can be utilised to unravel the complex metabolite responses of plants to pathogens. An advantage of these metabolomics approaches over genomic and proteomic approaches is the ability to determine the exact metabolic state of the plant after pathogen infection.
This review will describe secondary metabolites involved in mediating the outcome of plant-pathogen interactions in cereals. Secondary metabolites will be discussed in the context of chemical class rather than their roles as phytoanticipan or phytoalexins as a number of compounds fall into both these categories in different species. These secondary metabolites offer tremendous potential for plant breeding and metabolic engineering in agriculture to aid in controlling existing disease losses [
Benzoxazinoids (Bxs) are a class of secondary metabolites widely distributed in cereals discovered in the 1950's and since found to have a range of biological roles including alleopathy, resistance to insects and defence against pathogens [
Simplified diagram illustrating the biosynthetic pathways of the discussed plant secondary metabolites involved in pathogen defence. Cyanogenic glucosides, flavonoids and benzoxazanoids are all synthesised from the aromatic amino acids derived from shikimate. Saponins and terpenoids are synthesised via the melavonate or non-melavonate pathway in plants, which occur in the cytoplasm and plastids of plants respectively.
The most common Bx in rye and wild barley is 2,4-dihydroxy-2
Diagram illustrating the structures of a number of plant secondary metabolites belonging to the major classes of defence compounds discussed.
A recent study used LC-MS/MS to quantify Bxs in 54 Danish wheat varieties discovering the concentration of six Bxs to correlate positively with resistance to Fusarium Head Blight (FHB) [
The terpenes and terpenoids are the largest and most diverse class of secondary metabolites with over 40,000 compounds described [
A recent study collected volatile organic compounds (VOCs) released by oat, barley and wheat in response to infection by three
Investigation into terpenoids with antifungal activity against two maize pathogens
Flavonoids are a large class of phytoanticipan and phytoalexin phenolic metabolites synthesised from phenylalanine in the shikimate pathway (
A number of preformed flavonoids (phytoanticipans) belonging to the anthacyanidin class inhibit the growth and spore germination of the fungal and bacterial pathogens of rice
A number of flavonoid compounds require compartmentalisation in the cell to avoid mutagenic and oxidative effects of the active compounds and intermediates in their synthetic pathways. In maize, barley and rye a number of different mechanisms of vacuolar import have been identified including a vacuolar ATP-binding cassette (ABC) transporter, multidrug resistance-associated protein like ABC transporter and pH-dependent vacuolar flavonoid/H+ antiporters [
Cyanogenic glycosides are present in over 2,600 plant species and a number of cereals including wheat, barley, oats, rye, sorghum, millets, sugar cane, maize and rice [
There is evidence that the production of cyanogenic glycosides occurs at a significant cost to the plant suggesting they must play a role in survival against herbivores or pathogens [
High performance liquid chromatography (HPLC) and LC-MS/MS for the analysis and identification of cyanogenic glycosides has recently been exploited for the sensitive detection of these compounds and their derivatives [
Saponins are a class of glycosylated triterpenes; steroids and steroidal alkaloids synthesised from the mevalonate or non-mevalonate pathway in plants (
Saponins have been implicated in the resistance of oat to
In the past, research on saponins has proved difficult, relying on HPLC methods or non-specific stains [
This review has covered the major classes of secondary metabolites present in cereals with important roles in pathogen defence. The majority of these plant secondary metabolites, whether preformed or induced, are compartmentalised within vacuoles or other specialised cellular compartments to avoid self-toxicity. A common mechanism of activation is enzymatic hydrolysis following vacuole disruption during tissue damage caused by the pathogen. Other compounds accumulate in the apoplast such as benzoxazanoids, which act as defence regulatory signals. Volatile secondary metabolites are also involved in pathogen defence with a number of volatile terpenoids demonstrated to increase in response to pathogen attack. Infected plants are also capable of stimulating volatile release from uninfected neighbouring plants, a feature that may be invaluable to increasing crop resistance to pathogens. The mechanism of action of the antimicrobial secondary metabolites discussed in this review varies from membrane disruption and pore formation (saponins and terpenoids) to interference with aerobic respiration (cyanogenic glycosides) and inhibition of microbial enzymes, chelation of metals required for microbial enzymes and polymerisation forming crystalline physical defence barriers (flavonoids). Microbes are constantly evolving mechanisms to overcome the activity of such compounds as are plants evolving new defence mechanisms. If the potential of metabolite engineering is harnessed, cereals may not be limited to only the classes of secondary defence compounds discussed in this review.
The discovery of secondary metabolites with roles in pathogen defence has been catalysed in recent years with technical advances in mass spectrometry and high throughput metabolite profiling. Many of the metabolites described in this review have been identified via gas chromatography and headspace analysis of volatiles coupled to mass spectrometers in addition to liquid chromatography-mass spectrometry and occasionally nuclear magnetic resonance spectroscopy. The current bottleneck in these techniques is the processing of the large data sets generated and positive identification of all the compounds analysed.


text:
With spring now upon us, who doesn't want to take advantage of the invitingly warm weather? When the sun pops out and the flowers begin to bloom, I know where everyone on campus is heading—the quad. I've terribly missed my school's glorious quad area this past winter season and I feel everyone is ready to embrace all that is spring, which definitely includes utilizing the quad. Whether it's studying and lounging on a blanket or throwing a Frisbee, most of these activities take place on your quad, which makes it the perfect place to test out your new spring apparel. This Fashionisto surely took advantage of this opportunity. From his nautical boat shoes to his quilted jacket and to his effortless infinity scarf, he's all set for strutting across the quad.
Boat shoes certainly scream spring and they're often the first piece I jump to when the weather becomes warmer. They're an ideal accessory since they can be paired with almost any type of outfit. Whether it's a spring skirt, a pair of pastel shorts or a pair of dark denim jeans, boat shoes will match them swimmingly. They're also quite comfortable, which makes them an all around wonderful go-to spring shoe.
Moving upward, this Fashionisto's nice layering of a simple white and navy striped button-down and an army green quilted jacket create a perfect combination for the sunny weather you'll be enjoying on the quad. The jacket adds just the right amount of warmth, but can easily be shed, which makes it an ideal versatile piece. To finish his outfit off, the effortlessly thrown on infinity scarf truly pulls this outfit together. It echoes the subtle tones in this Fashionisto's striped button-down, yet is also a unique piece on its own. Put all of these stylish and subdued toned pieces together and you're all set for a day of lounging on the quad. Even if you don't happen to finish that homework you should be doing, at least you're a stylish example for your fellow classmates!
One Simple Change: If you're trying to be more productive and ambitious with your workload and are heading to the library instead of the quad, you can still dress stylishly in this setting. Instead of the button-down and quilted jacket combination, try a comfier shirt, such as an elbow patch sweater. Your outfit will be more relaxed and comfortable to study in, but will still have that stylish element.


text:
Rise of the Tomb Raider (Steam)
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- Woman vs. Wild - Conquer a world fiercely protecting its secrets, endure perilous conditions and unstable landscapes, face dangerous wildlife that act as guardians to ancient tombs, and explore huge interactive environments
- Awe-Inspiring Deadly Tombs - Explore huge ancient spaces littered with deadly traps, solve dramatic environmental puzzles, and decipher ancient texts to reveal crypts as you take on a world filled with secrets to discover
- Guerilla Combat - Use the environment to your advantage, scale trees and dive underwater to avoid or takedown enemies, configure Lara's gear, weapons, and ammo to suit your play style, craft explosives on the fly to sow chaos, and wield Lara's signature combat bows and climbing axe
- The Most Stunning Tomb Raider Game Ever Made - CG film quality characters and FX, real-time cloth and body physics, and full performance captured cut-scenes deliver the most immersive and visually stunning Tomb Raider game ever made
descriptionLara Croft once again lights up the torch in Rise of the Tomb Raider, sequel to the exceptional Tomb Raider reboot from 2013.
Rise of the Tomb Raider features the next suspenseful and thrilling adventure of Lara Croft in a vast world full of puzzles and mystery as she seeks answers and treasures in multiple destinations around the world. Feel the adrenaline from death-defying and jaw-dropping stunts of Lara Croft in her expedition in Rise of the Tomb Raider.
Following the ordeal in Yamatai Island, Lara Croft is beset with mental trauma, hallucinations and unexplainable mysteries that threaten her very core. At the same time, a dangerous and mysterious organization is also after her, especially for what she knows from her last adventure.
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|Official Release Date
|Jan 29, 2016
|Action Adventure
|Region Free
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text:
For the next few hours, police used search dogs to comb the woods for the man.
She decided I needed a "comb through," which meant it would be straightened from the root to the tip (even better in my mind).
He called on Libyans to "sweep through Tripoli and comb it for traitors."
comb the coast, and you could stumble upon that dream weekend retreat.
I wanted to comb it, to swing it, to spin around in circles.
Nearly all the men carried in their hair a comb projecting in front or on one side.
I say that I will not cut my hair or comb it until I am king of all Norway.
A silk thread may be tied to the wire, but a narrow silk ribbon is better than thread, as it will hold the comb steady.
"No, for the comb of the honey is pure wax," the Queen Bee replied.
She is forbidden to touch her head, for which purpose she uses a comb with three points.
Old English camb "comb, crest, honeycomb" (later Anglian comb), from West Germanic *kambaz (cf. Old Saxon and Old High German camb, German Kamm, Middle Dutch cam, Dutch kam, Old Norse kambr), literally "toothed object," from PIE *gombhos, from root *gembh- "to bite, tooth" (cf. Greek gomphos "a molar tooth," Sanskrit gambha-s "tooth").


text:
Fashionista's Flea
The Riviere Agency, LLC
Saturday, January 26, 2013 from 9:00 AM to 12:00 PM (EST)
Who's Going
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Sara Haughty
San Francisco, California
San Francisco, California
Luke Picard
London, United Kingdom
London, United Kingdom
Rick Vespucio
Florence, Italy
Florence, Italy
Event Details
Have questions about Fashionista's Flea? Contact The Riviere Agency, LLC
When & Where
Whitelaw Hotel
808 Collins Ave
Miami Beach,
Saturday, January 26, 2013 from 9:00 AM to 12:00 PM (EST)
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The Riviere Agency, LLC
The Riviere Agency, LLC is a full service Integrated Marketing Communications and Public Relations firm with offices in Miami and New York. Our team has over 20 years of combined experience in the fashion, beauty and lifestyle industry and a proven track record of providing affordable integrated marketing, public relations and event production services that rivals any big agency.
Fashionista's Flea
Things to do in Miami Beach, FL


text:
Sylvia Frances Chan
Paris - Poem by Sylvia Frances Chan
Just written media August 2011, for Poetfreak.
Recently last July I was invited by a good friend to come to Paris.
When still living in the tropics I loved to study Beaux Arts in Paris, but....since I was the only girl (be noted: my big bro was the only boy....LOL...) , my mom forbade me, I may not study in Heidelberg either! Since then Paris had become its home in my head, I really enjoyed my very first visit to Paris, I was really very excited...and last July I was back again in Paris, this time I was invited....all previous times I invited myself...
Paris was my first Love
so excited for the first time
I thank God above, my love
have met Paris again and a good rhyme
Paris was my first Love
but not my last
I forget sometimes the Present
but I'll never do that with the Past
Sylvia Frances Chan
© copyright Sat Aug 13 - 2011 -
All Rights Reserved
Published August 13,2011 in POETFREAK
Topic(s) of this poem: love and art
Form: Quatrain
Poet's Notes about The Poem
Comments about Paris by Sylvia Frances Chan
Donward Bughaw (6/15/2016 7:30:00 PM)
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Sylvia Frances Chan's Other Poems
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Stopping By Woods On A Snowy Evening
Robert Frost
A Dream Within A Dream
Edgar Allan Poe


text: Based on pictures I've seen, I still can't figure out a good way to differentiate between tsuga canadensis (eastern hemlock) and abies balsamea (balsam fir)... well, at least not without taking a chunk of the wood and seeing how hard it is. I'm thinking that I must not be paying attention to the proper details. Can anyone help me with characteristics to look at/for that might help me?


text:
The Faculty of Psychology is dedicated to provide the best services to the future experts who will work to understand personal experiences, anxieties, hopes, disappointments, optimism, confidence, ambitions and generally of human behaviors is relevant for social wellbeing and development. Specifically such issues are at the focus of psychological study. The study program of Psychology aims to provide opportunities for scientific approach as well as offer opportunities to apply the knowledge acquired in the course of the studies on various areas of social life.
Our graduates from this program shall have the opportunity to get involved and contribute in many areas of social life: on pre-school institutions, for the purpose of facilitating the socialization and stimulation process of various aspects of psychic development, on elementary and secondary schools, to advance the educational and learning process, in industry and various companies, for the purpose of stimulating and motivation on work as well as for establishing good interpersonal skills, in health, in preventing mental health risks, in sport and other areas related to human communication.
AAB has selected motivated staff and experts that have a clear vision to establish the Faculty of Psychology to successfully accomplish the above-mentioned scientific and applicative goals.
Program Accomplishments:
- Application of advanced psychological knowledge, including critical understanding of theories and principles;
- Application of critical understanding of key concepts, principles and theories on everyday work or further education in the area of psychology;
- Advanced skills that demonstrate ability and innovation to resolve complex and unpredictable problems on the study area;
- Implementation of defined research and development projects and identification and implementation of relevant outcomes;
- Demonstration of originality and creativity in working on professional issues;
- Cooperation with others to assure improvement, development and new ideas;
- Use of complex ethical and professional issues in compliance with the codes;
- Current professional and ethical practices;


text:
There is always good advice here, and I've got almost a week with the Harman Mag Stoker and I was wondering if I could use any thermostat with it? Right now I'm running the White Rogers (?) square unit that came with it. I have a hard time seeing the set pointer, so I'd like something easier to see.
As a kid, we had the usual round Honeywell thing on the wall, would one of those work?
Also, as another idea I could go digital, and have the house get cooler at night for better sleeping, and really warm in the morning. Would one of those work?
Inside the White Rogers there is some setting that I didnt touch, but could that be some kind of delay mechansism or something that I'd need the equivilant with another thermostat?


text:
Written on: 07/01/2010 by lunaclara (1 review written)
I would, in fact, urge a friend to use this company. The service was fabulous, the price reasonable, and the product great. Ireland had done some recent road improvements that didn't show up, but the only times we got lost were because of bad addresses. And we drove around the country for ten days.
As rated by our community of reviewers
" Avoid HireGPS - appalling service when satnav broke down " Read More
Written by PeterB61
" Defective Tom Tom " Read More
" Sat Nav hire for USA trip. " Read More
Written by Glyn49
" AVOID AVOID AVOID!! " Read More
" Poor Customer Service " Read More


text:
Would you like to save as your currency permanently or for this visit only?
Excellent facilities for golf and central for making day trips in the area.
Excellent food and service, hotel recently refurbished to a high standard. Fabulous views. No real ale in the bar.
Better than expected for the price. ~Good service and room comforts. Hotel is very badly signposted - very hard to find, especially on dark rainy nights!
Position - Nice restaurant - Friendly staff Garden view means looking up a steep gradient which could do with some landscaping
The position of the hotel was beautiful. The staff were without exception very cheerful and helpful. The room in the new block was excellant and very large with beautiful views overlooking the golf course and coast.
Great food. Fantastic staff. Lovely views. No
Generally a good value hotel with good service and an obliging staff
A good hotel with excellent staff. None
the room vas very nice with a subperb view the room had cobwebs around one of the lights
The executive rooms are of a basic design but clean and fresh/new. The bed was very comfortable. The hotel is relatively isolated so a quite night is assured. Hotel restaurant food again is elementary but cooked well and very edible. I arrived late for breakfast (restaurant closes at 9 am week days) and staff still serve me with a smile. The view across the North Sea is to die for and the area is 'safe'. A great location for walking if you have the time. I visit the area for my work 9 miles away and will certainly use this hotel again.
The staff were really friendly and helpful. There was a good atmosphere and buzz about the hotel without being roudy. The food in the restaurant was excellent and good value for money. Excellent all round. None.
Was only using it as a base as I was attending a family event in the area. Breakfast was very good.
good helpfull staff evening meal served in bar area was expensive poorley cooked and presented
Easy access. Location vs event. Good breakfast. Water only scalding or freezing - nothing in between for shower! Parking - spaces too tight. Bathroom light delay - confusing. Could have been more tv channels.
The location of the hotel right at the beach; the never ending wish of the staff to want to help you and the hotels ambiance.
The situation, and the roomy room. The evening meal...lackadaisical service by otherwise pleasant staff...Please, give the recipee for Yorkshire pudding to the chef...it does not have to have self raising flour, and should not look like a spoutnik...and, if clients are waiting at the carvery counter of the restaurant, to be served, whilst 4 members of staff busy themselves serving the bar meals, just smile and acknowledge they do exist...Just a thought...and say" we shall be with you shortly..". A good head waitress and receptionist, ... and a gloomy chef...Nothing that cannot be put right in a tick!
good location view of sea from room restaurant and bar on site offstreet parking friendly staff
Location. Size of room, Wifi.
staff were so good ,the receptionist brilliant didnt get her name
the staff were very friendly the room was brill and clean overhall we found the hotel great and would highly recommend


text:
Single teenage mom in Alaska
Dear Bristol Palin,
First of all, you came to the right place. Neither of us is a huge fan of your mom's. One of us thinks she's sort of OK and the other thinks she's sort of embarrassing. We both think the best part about your mom is all the Tina Fey that came with her. So we're not fans but we're also not haters. It's kind of a big, amorphous mass of not really caring. What we are, in your case, is objective.
Honey, what in tarnation are you thinking? Are your parents going to be mad? That's a big yes. Are you doing the right thing? Ummm... Let's think about that... No.
First of all, your baby-daddy is an asshat. Notwithstanding the niceness you may now be experiencing, he is not a good dude. We are totally sympathetic to your desire to have everything work out. To be a wife and a mom and to put all the douchiness behind you and be a family. And taking good care of your adorable and precious son has got to be priority numero uno.
And if you're doing this because you have just a wee bit of stored up bitterness you need to work through, well there is no better position from which to inflict enduring emotional and physical pain that that of legally married spouse. But that is not a good reason to get married, no matter how much he deserves it. Because you can totally square up on him without tying the knot. Or you can call us and we'll do it for you. But we suspect that your impending nuptials have nothing done with a desire to roundhouse kick him in the face like you were Chuck Norris. Though we really wish you would...
Because your future husband is a turd, Bristol. And you know that already, so please think things through a little more. Let's map out the past year or so, to help clarify...
- You guys break up. He decides to work off his anger by bad-mouthing your whole family (including your baby brother with Downs Syndrome - that was a classy move), posing for Playgirl and making a failed effort to launch an acting career using the stage name (this is not a joke) Ricky Hollywood.
- Your mom quits her job as Governor and starts making serious bank on the lecture circuit. Your family now has lots of lovely money, which we imagine would slightly lighten the burdens of an 18-year old single mom.
- Three months ago, the press starts reporting that you have also hit the lecture circuit and are earning $30,000 per speech. Five minutes later, Senor Hollywood is sending you texts telling you how nice your ass looks in your Hollister jeans. And how he misses you. And how is the baby doing? And can he come over and bring you a Diet Coke and a Crunchwrap Supreme?
- He makes a public apology to your parents in which he hopes to be forgiven for his "youthful indiscretions." Meanwhile he is secretly banging their daughter. Again. Then he pops the question again and like a strong, intelligent, independent woman of substance, you
tell him to go f**k himselfsay: "Squueeeeee! Yes! I love you soooo much!"
- You two idiots are too chicken-schmidt to tell your families what you're doing. [Editor's Note: Though isn't his mother in jail for selling OxyContin or something? Yes? Sigh... Don't let her babysit.] Because sneaking around having sex with this guy worked out really well for you last time, right? So you sell the story to UsWeekly and your parents find out all the rumors are true via the press. Well done, Bristol.
- So congratulations! You've successfully humiliated and pissed off your parents and you got a man in the bargain! Not just any man, either. The dude that knocked you up in high school, abandoned you and your son, and then tried to destroy your family while showing off his wiener as "Ricky Hollywood." Come to think of it, if you really want him back - maybe you deserve each other.
Also, a final bit of advice. We strongly suggest having your mom hold a hockey stick poised and at the ready when you ask Levi to sign a pre-nup. The second he hesitates - THWACK. We'd even be there chanting: Go, Sarah, go!
Good luck, Buttercup. You'll need it.
xo, Kate & Lydia
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(c)Herding Turtles, Inc. 2009 - 2010


text:
Boa flow has been designed to accommodate the various working environments and changing requirements of creative professionals. Integral to the bag's flexible design is its collapsible bottom compartment, which serves as a protected, separate place for your camera or large headphones. When those items are not needed, collapsing the compartment maximizes the main volume for books, documents, or other large items.
A highly protective laptop compartment, extremely durable YKK zippers, a ballistic nylon exterior with waterproof coating, an ergonomically designed shoulder strap system with three adjustment points, a breathable back padding design, super soft neoprene mobile phone pocket, and stretchy side pockets for water bottles are just a few of the benefits that make Boa flow the ideal bag to move creative gear.
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"Booq backpacks are in my opinion exceptional. Booq backpacks are in my opinion exceptional."
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"Boa Flow M Digital. Fantastic item, lots of space and specific compartment. A little bit heavy thus."
"Wow. Great bag, so many pockets, just what i need for day trips. I can carry everything i need, cameras, laptop, all my paper work, i love it, awesome bag. Now i need a bigger version for my clothes."
"Stylish and sturdy. It's a great backpack for carrying your laptop and camera. However the bottom camera compartment is not as big as i'd expected. It won't fit canon 5d mkii + 24-70mm lens. A workaround is to put the camera inside, and it's quite good since it's not really moving around and it has plenty of room to put other equipments in. It's generously padded even though it's slightly heavier than other laptop backpack, it's ergonomic so it will stretch your back and doesn't make you hunch."
"Perfect for what I need it for. Many of us may be thinking twice with buying things of the net for those that we have not physically seen. I thought it was a gamble buying this bag without seeing it physically but no. It turnout to be what i expected, perfect to fit all the things that i need in there. I don't have to remove the lens off my camera fits all the little gadgets i carry lots of times. I should say it is a perfect bag for what i needed it for."
"Great service. Excellent backpack, outstanding service. I will certainly have you guys in my bookmarks. :)."
". Excellent build quality and storage capacity, certainly lives up to the hype in those regards. Could probably do with a pocket or two on the straps though (ala the mamba shift) and some additional compartments in the main section. Still, you'll be hard pressed to find a bag that can carry more and still be comfortable to wear."
". The bag was a great gift for my son and he uses it every day, loves the bag. Thanks for stocking this piece of equipment."


text:
Mr. COHEN. People sometimes ask why we can't find common ground. There's an area we should be able to find common ground on--and we don't--and that's funding for the National Institutes of Health, which is going to be cut in the sequester by close to a billion dollars. There was an amendment in the Senate that tried to put funding back in the continuing resolution for NIH, and it failed on a party-line vote, with 54 Democrats and Independents voting ``yes'' and 46 Republicans voting ``no.''
Republicans say the reason they want to cut spending and voted the sequestration in is we're putting a debt on the next generation. Let me submit, Mr. Speaker, that the research that's done at the National Institutes of Health to find cures for cancer, heart disease, diabetes, Alzheimer's, AIDS, and post-polio cures and treatments will affect the next generation more than this generation.
We talk about the Department of Defense. The Department of Defense should be the National Institutes of Health, because the enemy is disease, and we need to conquer it and keep our loved ones alive and keep ourselves alive and have better cures.
We talk about infrastructure--and I support that--but the most important infrastructure is the infrastructure of the human body. And that's what the National Institutes of Health works on. We should work together and fund the National Institutes of Health for all of our constituents.
Source: http://thomas.loc.gov


text:
Editor's note: This story is by Mark Davis, staff writer at the Valley News, where it was first published on Oct. 10, 2012.
Justin Ciccarelli drove slowly in the right hand lane of Interstate 91 early Saturday morning, wary of the blackness and the gentle rain that enveloped the highway.
He had finished his shift at Dartmouth College's Department of Safety and Security around 2 a.m., and just started on the 30-minute trip home to his wife and two young children when he came upon what he assumed was a dead animal in the road.
By the time Ciccarelli realized what was really lying on the highway that night, it was too late to swerve, too late to brake, too late to do much of anything except to pull to the side of the road, call 911 and check for signs of life he doubted would be there.
Loathe to slip into darkness, Ciccarelli said yesterday he has barely slept in the four days since his vehicle struck 24-year-old Mikhail Lomakin, a Dartmouth graduate student who was found dead after he was struck by at least one other vehicle that night.
"That's what I have in my head now when I close my eyes," Ciccarelli, who is chairman of the Windsor Selectboard, said in an interview. "(I'm) not wanting to close my eyes or be in the dark right now. I know in my heart I didn't do anything wrong — it doesn't make the situation any better."
Those fateful seconds replay in his mind in an endless loop.
"I saw something and I didn't know what it was," Ciccarelli, 37, said. "I thought maybe a deer carcass. I was just like, 'What is that?' I didn't have enough time to react or swerve. So I thought my best bet was to straddle it, and maybe it wouldn't hit my tires and damage my car. It was my first thought — damage to my car. And, when I got up to it I realized, 'Holy cow, it's a human being,' and at that point, there was nothing I could do."
He pulled over, called 911 and activated his hazard lights and an application on his smart phone that emits a pulsing strobe light, to warn off passing vehicles.
Instinct, he said, kicked in: Ciccarelli spent several years working as a dispatcher from the Vermont State Police, and he knew some of the troopers who would soon respond to the scene.
"I've dealt with many situations like that before — it doesn't prepare you for being involved and seeing it," Ciccarelli said. "I knew what I had to do — dial 911 and see if he was alive — but I don't know how … (nothing) prepares you to see what you see. I don't know how troopers do it."
Several passers-by stopped and offered to help, Ciccarelli said. Police were on the scene quickly. He stayed on the side of the highway until 8 a.m., talking to detectives who impounded his car, which remains in a police lot.
Another driver had hit Lomakin shortly before Ciccarelli, police said. Shane Harlow, 47, of Quechee, called authorities after it happened, Vermont State Police Capt. Ray Keefe said. Neither driver did anything wrong, Keefe said.
Harlow could not be reached for comment.
Evidence suggests Lomakin may have been struck first by another vehicle, before Ciccarelli and Harlow, and police are investigating that scenario.
"Could that have happened? Absolutely," Keefe said. "Can we say definitely it happened? No."
Only three months ago, Ciccarelli landed at the campus Safety and Security Office. His agony is only made worse by knowledge that the man in the road was one of the students he had been hired to protect.
Lomakin, a Russian native whose family emigrated to the United States in 1996, arrived in the Upper Valley only a few weeks ago, to begin a doctorate program in physics.
Lomakin, an only child, came from a family of achievers. His grandfather, grandmother and uncle were all physicists. His mother is a computer programmer.
In his last semester at the University of Massachusetts-Lowell, where he studied atmospheric science, Lomakin took 25 credits and held a 4.0 GPA. In his free time, he learned to love physics.
His curiosity in the subject was piqued when his grandfather gave him a book discussing physics and black holes, his mother, Mariya Lomakin, said in a phone interview yesterday from her home in Groton, Mass.
Lomakin spent all of last summer studying for fun, plowing through books that his grandfather and uncle gave him and listening to lectures that he downloaded online.
"He taught himself physics better than students who (studied) physics in undergrad," Mariya Lomakin said.
He applied to several graduate schools, but most were apparently bothered that Lomakin didn't have an undergraduate degree in physics: Dartmouth was the only one to accept him, Mariya Lomakin said
"He was quite happy about it," Mariya Lomakin said. "He wanted to try something new and it seemed a very good choice because it was not too far, and not too close to home. He loved it."
"One more day in paradise," Lomakin wrote in a recent Facebook post in mid-September.
Mariya Lomakin was scheduled to make her first trip to the Upper Valley to visit her son this weekend. His funeral is scheduled for today in Massachusetts.
The family, she said, is preoccupied with the same question that haunts Ciccarelli, Lomakin's friends at Dartmouth and the police: What was he doing on the interstate?
"I have no clue," Mariya Lomakin said "He wasn't that wild. To go on the interstate at night, I can't imagine. I can't imagine."
Keefe, the state police captain, said investigators have some evidence that Lomakin had been drinking on Friday night, but they are unsure if that played any role in his death and are still trying to piece together the final hours of his life.
"At the end of the day, we may never know what led him to be there," Keefe said. "There is some evidence of alcohol, but we have no idea about level of impairment at this point."
Anyone who saw Lomakin that night is asked to call the Vermont State Police Royalton barracks at 802-234-9933.
"This is a tragedy for his family, for the school and for the region, and we feel that too," Keefe said.
Many are hoping that police can eventually provide some answers.
"For the sake of his family and friends, and for the sake of me, too, they need to know what he was doing there in the road," Ciccarelli said.
Mark Davis can be reached at [email protected] or 603-727-3304.


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LOS ANGELES, March 9th, 2012 – Josh McLaughlin is joining Focus Features as senior vice president, production at the worldwide film company. Focus president of production Jeb Brody made the announcement today. Mr. McLaughlin begins work this month. Reporting to Mr. Brody, he will be based in Focus' West Coast offices and will work with the global Focus production team in New York, London, and Los Angeles.
The executive is joining Focus directly from his position as executive vice president at Chernin Entertainment, the new media company where he worked for nearly two years with founder and chairman Peter Chernin and president Dylan Clark, growing the film production arm.
Previously, Mr. McLaughlin was executive vice president, and co-head of the motion picture division, of The Mark Gordon Company. Among the movies that he produced there was Kasi Lemmons' award-winning Talk to Me, starring Don Cheadle and Chiwetel Ejiofor, which was made with Focus Features. He worked with Mr. Gordon for two years at Mutual Film Company and then for eight years at The Mark Gordon Company, after beginning his industry career at The Gersh Agency.
Mr. Brody said, "Josh is a gifted executive who not only has extensive relationships within the creative community – particularly with directors and writers – but who also has a knack for finding and developing smart material. He will be a great addition to the Focus team."
Focus Features Hires Chernin Entertainment's Josh McLaughlin As SVP Production
13 Comments
Couldn't be happier for Josh. I've worked with him a few times now, and can't say enough good things about him.
JM is one of the sharpest execs I've ever met and leaves a lasting impression. There were too many high-level fish in the Chernin waters for him to really shine; this is a great move.
Good for Josh ! A terrific guy who worked his way through the ranks,and finally got the brass ring.
Go Josh!
Josh is one of the best execs. out there. You couldn't find a nicer guy who gets things done and has great taste. As a manager, I wish there were more execs out there like him! Nice to see the good guys win for once…
Big fan of Josh here. When he was at Mark Gordon, he brought me into Paramount to pitch on a remake idea years ago that didn't work out. That said, he remained one of my favorite execs to work with. It's nice to see good things happen for him. He deserves it.
Excellent for Josh! Focus is lucky to have him. One of the best execs out there.
Likability=high. Track record = "Talk to Me" and a John Cena movie. Jeb is a strange dude.
Outstanding. Josh is an absolutely stand up guy, and to be honest, the Cena movie wasn't half bad. Great hire and great move for JM.
Nice guy, but sounds like a bit of odd choice from both sides.
WHAT GOES ON at that Chernin joint? Richest deal in town, coziest golden parachute of a company, should be a cool creative haven – and instead they've made ONE movie in 3 YEARS and it was a (perfectly cool, thanks to Weda) Planet of the Apes sequel to a sequel to a sequel that was already underway when Chernin glommed on. Moreover, every nice and smart exec there (Nicky Weinstock, Tasha Brown, Linsday Stanford, Josh McLaughlin, etc. etc.) runs for the hills. One has to assume it's a hellhole. What a wasted opportunity.
Totally toxic. From what I hear their success is built on fear, which may work for some, but in this case clearly has repercussions. Wasted opportunity indeed.
Lets not rush to judgement on Chernin. Apes is awesome and it was all them. It just wasn't the right fit for either Josh or them. Both parties will go on to great success, I hope.


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10w-30 in a 330i
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Originally Posted by
Since winter is coming, you should have gone from a normal purchase of 10w30 to a winter purchase of 5w30, you went backwards. 5w30 is thinner when cold, 10w30 is thicker. The thin oil circulates easier in cold temps, therefore it gets to the critical points sooner. Where's Tracy, near Sacramento, right? If I am right, then you live in a climate where 10w30 or 5w30 is no big deal, if you lived in Fargo then you would probably want to know more about oil viscosity so you do not make this mistake again.
I was in a BMW parts department a few weeks ago, and looked at every bottle of oil on the shelf in the customer area of the store, not one listed itself as LL-01. The Owner's Manual says that API Grade SM or higher is good. I believe the API Grade on the shelf at Walmart these days is SR. I have never seen a bottle of oil that says it is LL-01, except I did see that spec once about a year ago at my local dealership, but on a recent trip I did not see it. There is no published spec in any User Documentation that says, LL-01. All available user documentation says API Grade SM.
You can, and should, use the best quality oil you can find, and this includes the suggestion that you use LL-01, but your motor will not turn to a heap of molten metal on the way to work someday because you bought motor oil at Walmart. It is far more likely to turn to a pile of molten metal because the viscosity is way too heavy or way too thin, or it is some old motor oil you found in the corner of Grandpa's barn that he bought in 1950. If you buy the highest API Grade, which I think is about SR or ST today, and it is the correct weight for your climate, then your car will be fine.
The owners manual says LL01. It also says if not available then ACEA A3, B3 oil is OK. Oh that is everywhere except the U.S where they omitted it.
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Please recommend me a good spot in 50 miles radius of Miami
I'm looking for a good spot for intermediate-advanced level with surf school/rental and nice but not expencive inn or apparts nearby.
Will rent a car so +- range from anywhere doesn't matter.
I'm from Russia and will have a 7-8 days after finishing my business there. I'm really good in snowboard and windsurfing freestyle. And want to advance my surfing technique which is now around zero :)
Mmmm, I don't know why 50 miles. Actually 200-300 miles from Miami also no problem. If the spot is good for me.
So the best answer I expect to get is spot/appartments/school names.
skype don_radja


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Photo: Catherine Buell
Overgrown square in Pripyat - the company town built to house workers at the Chernobyl Nuclear Power Plant. It was evacuated in the days following the explosion and meltdown there on April 26, 1986. It will not be fit for human habitation ever again.
Watch Miles O'Brien's report on his trip to Chernobyl.


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B2 lucky:
[ + to infinitive ] You're very fortunate to have found such a nice house.
[ + that ] It was fortunate that they had set out early because the traffic was terrible.
More examples
- Let us pray for those who are not so fortunate as ourselves - the sick, the old and the needy.
- I consider myself fortunate to have had such a good education.
- She was fortunate to escape with only minor injuries.
- We certainly were fortunate to get a fine day for the fete, considering how wet it's been lately.
- "My husband arrived home just at that moment, which scared the intruder away." "Gosh, that was fortunate."
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In consecrated poverty we seek to share the lot of the poor and to unite in their cause, trusing in the Lord as provider.
— Constitutions of the Congregation of Holy Cross, 5:44
When I finished my term as rector of Moreau Seminary in May 2010, it took a week to box up and store my worldly possessions. For the past 14 months I have lived in East Africa, and everything I possess fits more or less into two big suitcases. I haven't missed a thing from my storage room, except maybe my fishing rods. Once again, my life has become simpler.
Though I'm living more simply, I do not claim to be an authority on living the vow of poverty.I like gadgets, and I like a good meal out once in a while. I have also been known to enjoy around of golf. Still, I want to live an authentic religious life, and it cannot be so without regular reflection on the meaning of consecrated poverty.
By: Fr. Pat Neary, C.S.C.
Superior, District of East Africa
Ordination: April 6, 1991
To learn more about religious vows in the Congregation of Holy Cross:
- Read a reflection from Fr. Tom Looney, C.S.C., on the blessings that come from the vow of celibacy.
- Read a reflection from Fr. Aaron Michka, C.S.C., on finding God's will through the vow of obedience.
- Check out posts on our vocations blog written by our men on the vows and their meaning.
- Read and reflect on Constitution 5, entitled "Consecration and Commitment", which treats the vows as we understand them and try to live them for God's glory in Holy Cross.
- Contact us in the Office of Vocations to talk about the vows and whether the Lord is calling you to them.


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Father: Leonhard Quickel b: 1607 in Nieder-Ramstadt, Darmstadt, Hessen, Germany
Mother: Anna Wfleonhard b: 1611 in Stein, Germany
Marriage 1 Catharina Enders b: 1643 in Schlierbach, Germany
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Food Allergies- Fact or Fiction?
Food Allergies- Fact or Fiction?
Seems like if you want to be in with the in crowd- you've got to get yourself a food allergy. Anyone who's anyone has got one, but how do you really know if you've got a problem? Dietitian Nigel Denby investigates……….
Millions of people mistakenly believe they are allergic to one food or another. All the celebs "have a food allergy" and report how finding theirs has helped them achieve that waif like figure or given the secret of eternal youth! In fact, less than 2% of the adult population (including celebs) have a true food allergy. Muriel Simmon, Chief executive of the British Allergy Foundation explains that "food allergy and food intolerance are often confused, as many as 1 in 3 people believe they have a food allergy." Silvia Anton, Healthcare analyst from Datamonitor says "More and more people are self diagnosing a food allergy, and are unnecessarily eliminating important foods from the diets." There's a mass of confusion and we live in a quick fix society. Sometimes it's easier to blame something like food allergy for the way we feel, than taking the steps needed to live a healthier lifestyle. Gail Pollard, a specialist Dietitian working with Food Allergy adds, "that although food allergy and in particular food intolerance are on the increase, and should be taken seriously, it's not as simple as cutting out bread or milk. Food allergy needs professional guidance from an expert."
Allergy or intolerance what's the difference?
An allergy can be everything from a runny nose, itchy eyes and palate to a rash. It affects the sense of smell, sight, taste and touch causing irritation, misery and in extreme cases can kill you. Basically, the body's immune system overreacts. Although the word "Allergy" is commonly used to describe any unpleasant reaction to a food, this can be misleading.
The word should only really be used to describe a reaction produced when the body "remembers" a food from a previous exposure and produces the "IgE" antibody which can be detected in the blood. "Sensitivity" is a reaction, which is an exaggeration of a normal side effect produced by food. For example, caffeine, if given at too high a dose in some people may cause them to "shake".
"Intolerance" happens when symptoms occur after eating something which your body cannot handle, it can't digest the food in the normal way. Symptoms of food intolerance range from bloating, nausea, fatigue, vomiting, abdominal pain and altered bowel habits.
One of the main problems with sensitivity and intolerance is that they are so difficult to diagnose. The conventional tests for allergies can't detect food intolerances, Gail Pollard explains "the procedures you need to go through to find a food intolerance need a massive commitment from the sufferer and supervision by someone who really knows what they are doing. Experience and an understanding of the condition and the individual are the most reliable tools you can use when dealing with food intolerance." Both food allergy and intolerance are more common in children than adults, but children often grow out of food intolerances. If a problem does exist parents need to take care to make sure that they are firstly excluding the problem food completely and then, that they are using other foods or supplements when needed to replace missing nutrients.
How do I get myself tested?
As the demand for allergy testing and the understanding of allergy grows, so too does the range of tests available. Unfortunately this can add to the confusion, and is where a lot of people can get inaccurate results and inadequate information about what to do with their results.
The British Allergy Foundation says "blood tests, skin prick testing and patch tests as the only reliable and accurate allergy tests." But there are a plethora of others available and according to Gail Pollard "these need to be viewed with some caution, and when it comes to food allergy, even the reliable tests are better at ruling out a problem than telling which food you are allergic to, for that you need to follow an exclusion diet".
Blood tests
This test measures the amount of IgE antibody you produce when you come into contact with an allergen (the food you are allergic to). Blood is usually taken from a small vein in the arm. The test is mainly used for people suspected as having an extreme reaction to a food, or for people with very bad eczema. Results are available within 2 weeks and are graded according to the severity of the allergy.
Skin prick testing
It works by pricking the skin with a minute quantity of suspect allergens, up to 25 can be tested at a time, results can be ready in minutes. A reaction shows as a small red swollen spot or weal on the skin. Skin prick testing can be conducted on adults, children and even babies. It still not known why, but skin prick testing is better ruling out food allergy than diagnosing it.
Patch testing
Similar to skin prick tests except the suspected allergens are applied to the skin, usually the back, using patches. The patches are worn for 48 hours and problem foods will show a red mark on the skin.
Medications like antihistamines can affect the results of all of the test which should only ever be performed by trained medics in a specialist allergy clinic.
Other allergy tests
There are dozens of other tests available often at a hefty price tag. The British Allergy Foundation says these tests "are not regarded by conventional medicine as being relevant, and have no place in the diagnosis of true allergies." There is very little science behind them and they often contradict all that we know about how the body works.
Applied Kiniesiology, measures muscle strength, and your resistance to foods. Practitioners claim to use your body's energy to help them diagnose.
The Auricular cardiac reflex method tells you about your allergies by monitoring your pulse when suspect foods are offered to you.
Some centres offer to give you a diagnosis by looking at your hair samples, where others will place drops of suspect foods under your tongue and monitor how you respond. And then there is Vega Testing where your magnetic field gives away the secrets of your allergies. Gail Pollard explains that she "sees many people in her clinic who have received completely inaccurate diagnosis of food allergies, and absolutely no advice as to how to avoid foods properly and safely."
When it comes to diagnosing food allergy, intolerance or sensitivity there is only one reliable and complete method. An exclusion diet involves following a very simple bland diet for two weeks, the diet only includes a few foods that are known not to cause a problem. After 2 weeks, if symptoms have eased off, you then have to begin the process of introducing one food at a time, waiting a few days to see if there is a reaction, and then trying another. Exclusion diets are hard work and take a long time! They should only ever be tried under the supervision of a dietitian or registered nutritionist, who can check that you are following it safely without compromising your self or wasting your time! When you have found the problem the foods, they can then help you to construct as complete and varied eating plan as possible.
So what if still think I've go a problem?
Let's say you suspect that you may have a problem with wheat; it's not as simple as thinking you'll just give up bread. Wheat is used in all sorts of foods you might never imagine, like ice cream and most processed and pre prepared foods. So, following a special diet can be tricky and means avoiding a lot of foods we all eat every day. If you do want an allergy test, you can find out where recognised tests are carried out in your area through your GP, practice nurse, health visitor or pharmacist. But, remember that these tests may not tell you what you are allergic to and will not be able to diagnose food intolerance or sensitivity. If you think you want to work with a dietitian or nutritionist, both the British Dietetic Association and the Nutrition Society websites list where you can contact someone in your area. If you suspect that your children may have a problem, then it's imperative that you don't dive in without help. Kids need every bit of nutrition you can give them, if you start needlessly taking whole foods out of their diet; they are going to be at serious nutritional risk. Gail Pollard explains, "so many people come to me thinking they have a food allergy, and for those that do, we can really help to improve their quality of life. For some people it's more a matter of making changes to an unhealthy lifestyle to help put them right." It seems that the bottom line is that food allergy and intolerance is a complicated business and that you really need expert advice before jumping on the band wagon.
We wanted to see what the really happened in the weird and wacky side of allergy testing. We sent Libby Young (33), a Bedfordshire Mum who works part time in London to do the rounds. Libby has none of the symptoms associated with food allergy, but to make sure we sent her for a skin prick test which ruled out allergies of any kind. We then sent her to a Hertfordshire clinic which offers a range of less conventional allergy testing. Libby told the clinic she suffered with bloating and feeling tired all the time. The therapist suggested Applied Kiniesiology and this is what he came up with.
Libby was asked to lie on a couch with her arm out stretched toward the ceiling. The therapist told her that he was "going to tune into her energy levels", he then offered vials of different foods to her hand and from the resistance he picked up from Libby he "diagnosed" her allergies. He told her she was allergic to yeast, sugar and mushrooms, and also that she had "issues with vitamin B"- he didn't explain what those issues might be. He explained that Libby didn't need to avoid yeast, sugar and mushrooms, but that if she came back for more treatments (at £50 a time) he would cure the allergies.
Libby does actually suffer from hay fever, which the practitioner claimed he had also managed to cure in her first appointment, when we spoke to Libby the following day she said "her eyes and nose were streaming as usual and that she didn't think she would be going back for any more treatments! She told us "the more I asked about the treatment, the more he just kept telling me that it was to do with my energies and that it was very complicated, he really seemed to believe in what he was doing, but I just couldn't see any logic behind the treatment."
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Put your feet up and relax at the Thistledown Inn Bed and Breakfast, a warm Victorian-era home offering an eco-friendly alternative to the traditional lodging experience. Thistledown provides ecological elegance in one of Morrisville's finest historic homes with a rich history. The Inn is an accredited Vermont Green Establishment and a Trip Advisor Platinum Green Leader. We practice energy efficiency and conservation, use nontoxic cleaners, and participate in waste reduction and linen reuse programs as part of our comprehensive environmental management plan. The well-appointed guest rooms are tastefully furnished with Vermont Crafted furniture. Thistledown is also proud to offer a full complimentary breakfast created from local and organic eggs, fruit, grain, meat, and dairy. So if you desire a lodging experience that nurtures the planet while pampering your soul, the Thistledown Inn B&B is the place for you.
WiFi available.
Thistledown Inn B&B
201 Park Street
Morrisville, VT 05661


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Spring Grove
Atron won the 2012 NSW Premier's Exporter of the Year award in Agribusiness. This is the fourth consecutive year that Atron has been a finalist or a winner of this prestigious award. In 2009 and 2010, Atron was a proud finalist in these Export Awards and in 2011, Atron was awarded 'Highly Commended' finalist for Sustainability in Export.
In 2009, Atron was also winner of the Asian Exporter of the Year.
These awards are testament to Atron's export leadership in Australia.
The NSW Export Awards showcase the top exporters from New South Wales, promoting them as role models to encourage other businesses to strive for success in world markets. The awards present a powerful opportunity to profile Atron and help build its export business. The win in 2012 at state level was a significant achievement and demonstrates Atron's focus on growing this key part of the business. Read More.
Atron is based on the east coast of NSW, the heartland of Australia's major beef producers.