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Great design and good build quality stand out here, down to the patterned, textured back that continues on the surface hidden behind the slider
The lack of a physical Windows button aside, this phone has the same excellent ease of use as other WP7 handsets
The lack of manufacturer program tiles is disappointing, but the WP7 features are standard across all phones, so are as appealing here as elsewhere. The camera isn't as powerful as some other WP7 phones but at five-megapixels, it's decent enough
The standardisation of processor and memory means it's as capable as other WP7 phones – that's fast, smooth and gorgeous
Like most smartphones, you'll need to charge daily, and don't be surprised to find significant battery burn overnight if it's not plugged in
Review by Sunetra Chakravati,12/12/2011 4:00:42 PM
Look and feel
Ease of use
Battery life
Snazzy looks, great Windows Phone 7 OS with latest software
Suited to large hands and pockets
How big are your pockets? No, not how rich are you, but your pocket size, because they're going to need to be big for this phone. This latest Windows Phone 7 handset is big in the hand and heavy enough to be memorable. But it's also a classy, good looking machine.
The styling is just great: a big (4.1-inch) screen with chrome surround and appealing textured back. The chrome edging looks particularly swish. And there's a QWERTY keyboard hidden behind the screen, just in case you're not mad on the WP7 virtual keys. But before you strain yourself sliding the screen sideways, it's hidden away at the bottom of a phone, for all the world like it was a standard slider phone. This accounts for some of the phone's bulk – where many slide-out keyboards offer keys that cover most of the area of the handset, here the phone only slides up a couple of inches. All that extra real estate stays hidden. As a result, it feels like a bigger phone than, say, the HTC HD 7 with its larger screen. The other WP7 handset with a physical QWERTY, the HTC 7 Pro, opted to put its keyboard in the other way round.You can keep the phone closed and type on the virtual keyboard in the usual way, and you'll have to use this method if you are entering text with the phone in landscape orientation. But if you do use the slide-out QWERTY (and it's a waste not to since it adds so much bulk and weight in your pocket) it's a pleasant enough experience with highly usable, if snugly placed, ridged keys. You can tap away at reasonable speeds – faster than on the virtual on-screen version, though that's not bad either. Both virtual and physical keypads include a smiley key to add icons to your texts, though confusingly the position of the key varies between physical and on-screen. Go figure. The screen is AMOLED, so it's vivid and colourful. And boy does it collect finger smudges, so you'll be rubbing it on your T-shirt regularly. It doesn't shed smudges as easily as an iPhone with its oleophobic covering, either.
Unlike Android phones, a review of a Windows Phone 7 handset won't have as much to say about the user experience. That's because Microsoft laid down minimum requirements for some elements (storage, for instance) and exact requirements for others (screen resolution, processor). So where the experience of using an HTC Android phone is wildly different from an LG Android, with different custom overlays and features, here things are much more consistent. Even so, the Dell Venue Pro seems to be the bare minimum of individuality: there are no manufacturer- or network-focused tiles on the home screen. In terms of hardware, where the LG Optimus 7 and Samsung Omnia 7 both have physical Windows buttons, here it's just a touch-sensitive Windows logo, but there's no physical movement and it can't wake the screen. The camera, another variable, is decent but at five megapixels not as striking as the HTC Mozart's eight-megapixel sensor. The storage is at the lower end of the scale – 8GB (there are no microSD cards in WP7 handsets) rather than the 16GB permissible. The Dell Venue Pro arrived with the NoDo update that includes the facility to copy and paste text. It's easy to use (touch any text, move the cursors to start and end, touch the Copy icon) though there's no option to cut, which is curious. And if you want to repeatedly paste the same text it's not very intuitive – you have to press the text suggestion bar that rests on screen above the virtual keyboard to restore the paste icon. Ah well, it's very welcome.Is this the best Windows Phone 7 handset? Its size is a bit of an issue and the Samsung Omnia 7 seems to have a little more to offer, but it's a good looking, enjoyable phone and Windows Phone 7 has a lot to recommend it, from the ability to launch the camera from the lock screen to the neat way the Maps function shows a satellite photo of the location automatically as you zoom right in.
There's no getting away from it, this is a hefty handset. And the QWERTY slide-out keypad that's responsible for some of that bulk is usable but not really necessary. Still, Windows Phone 7 is gaining potency, and part of its success is the knowledge that Microsoft-specified capabilities mean it's fast, slick and easy on the eye.


text:
San Diego Fire Prank
Photo: Getty Images
People in San Diego who logged onto the County's website or phone app for info on the fire near Rancho Bernardo got a surprising message.
Instead of showing where the fire was burning, the notes read, "fire in your pants."
San Diego's Communications Director says he saw the message shortly after it was made public.
Mike Workman says two people were assigned to create a map of the burn area, but someone added more than coordinates and neighborhood names.
Workman says an investigation will be done when they have more time.

subset: commoncrawl


text:
High Rise Granny Flats Help Families Afford New Condos
"It's been a long-time practice to build rental basement suites in houses, but suites in condos are a new idea."
Michael Geller, President of the UniverCity project at Simon Fraser University in Vancouver, heard from disgruntled students who said that the new condos would only be affordable to high income residents. In response, the developer incorporated three-bedroom condos, with one of the bedrooms designed as a self-contained suite -- either to be rented out, or occupied by another family member who wanted some independence.
"Each 22.3-square-metre room has its own entrance off the main corridor, with a bed, bathroom and kitchen."
"Geller said the model could work around the Lower Mainland of B.C., where housing prices are among the highest in the country. 'The idea could apply everywhere,' he said. 'Lots of people would buy a three-bedroom apartment, if maybe they could rent out that third bedroom for a while, until such time as their household is big enough.'"
"SFU students, who had been living around the campus in basement suites, snapped up the units."


text:
Opposite field
The opposite field refers to right field for a right-handed batter and left field for a left-handed batter. Most batters will tend to be natural pull hitters, meaning they will hit most pitches, towards the field on the side of home plate where they are standing; this is how one hits a ball with power, and most home runs are hit to the natural field. However, when a pitch is thrown on the outside part of the plate, an attempt to pull it will often result in a weak ground ball. Instead, a smart batter will push such a pitch towards the opposite field, where it is more likely to fall for a hit. Derek Jeter, for one, is a master of slapping such pitches to the opposite field for base hits.
Some contact hitters will also deliberately hit any pitch to the opposite field by using an inside-out swing. Even if a ball hit in this manner will not go as far as one hit with a full swing, this forces the defense to position its players in a much more conservative fashion, opening up larger gaps between players. In contrast, a player who insists on pulling every pitch while going for maximum power, what is known colloquially as a "dead-pull hitter", will often face a defensive shift that reduces his chances of hitting the ball safely.
For decades, only the very strongest hitters could hit a home run to the opposite field. This changed in the 1990s, as the spread of muscle-building exercises and steroids allowed many more such homers.


text:
Sponsored Products
|Internet Software
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Publisher's Description+
From Skyzoasoft: It has never been easy to manage your own FTP servers. Now it is free for all personal users. Protocol: FTP (File Transfer Protocol). Maximum Connections: Unlimited. Connection Mode: Active/Passive Mode. Server Mode: Application Mode / Windows Service Mode.
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What's new in this version:
Improved Windows Service Mode performance.
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LANDER CAMARERO Filmmaker
Theresa DanielleModel Female New York, New York, US
My MM URL: http://www.modelmayhem.com/theresa226
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About MeHi Everyone! Im Theresa, I took a break from model mayhem to focus on school but I am back because I realized this is where my dreams are. I have some experience mostly in hair and makeup promotions. I really love being photographed, and dressed up. I am really about building my portfolio and gaining experience. I live on long island Smithtown. If you have any questions, just let me know. Thanks for checking my page out!
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Those who abhor public prayer are at it again. They are offended by reference to deity among other things. There have always been those who do not recognize the unseen ("God cannot be proven"), never mind that they live in an age of invisible power, which keeps cell phones and computers running. And, what about our invisible human energy, love and hate, which packs a punch; creates and changes civilization?
Plainly, the, "if you can't see it — it must not exist" theory, fits in the "earth is flat" file.
Never-the-less, for prayer-deniers, because they cannot see Him, let's just say there is no God. Without doubt, prayer still holds a power of its own.
But, first, know that I believe in God. One universal God who loves all mankind. I also believe Christian principles played a weighty role in the founding of this nation.
We know, globally, persecution of Christians is on the rise, including here in the USA, while at the same time, other faiths are encouraged.
One devout East Valley Christian, a former church administrator told me, "We already have factions wanting to change laws in certain cities and states to reflect their very prohibitive and damaging religious laws. And the maddening thing is, the powers that be don't want to insult anyone, so they go along with it." That, while Christian traditions are under attack.
Perhaps you've heard. The nation's Supreme Court is considering prayer in public meetings (the town of Greece v. Galloway). Along with 17 other states, Arizona has filed briefs contending prayers should be allowed to continue.
For discussion purposes, consider prayer without God as a Receiver: Prayer generates unity in groups, which is needed to accomplish a common goal. Then, there's the need to focus, to acquire solemnity, even some humility, which serves as a reminder that it's not about "me," it's about the "good of all concerned." It's a ritual to still the mind and commit to purpose.
Prayer is one form of meditation, introspection which also utilizes natural laws. Prayer contains many meditation qualities, especially the clearing of the mind: www.artofliving.org/healing-power-meditation.Meditation (a moment of silence) apparently is viewed as so benign that atheists and non-Christians are unthreatened. Or, maybe meditation is viewed as a practice, which does not threaten political power. Which, brings us to the possible agenda of complainers and those who desire to word-smith public prayers. Just as long as no higher power is mentioned…
Something to ponder: Those who fear Christian practices are one thing, but those who support them and stand silent are another. Of course it's frightening to stand on the wall and proclaim that which is not popular; Christian scriptures offer many examples. On the other hand, because believers remain silently fearful, we see the predictable outcome.
And finally: Prayer is not owned by Christians. Soul yearning is as ancient as man. Yet, it is a power barely examined by civilization and in America's case, one which prides itself on exploration and genius advancements. In truth, it's astonishing so few explore the great domain of prayer.
I urge all who support public prayer (not just Christian prayer, but all faiths) to open your mouths in every venue available to you. When you gently put your name to your wisdom, then your belief will carry the power you seek. You then can claim the right to invite others to discover what you know.
• East Valley resident Linda Turley-Hansen (email@example.com) is a syndicated columnist and former Phoenix veteran TV anchor.


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The Kensington Monaghan Farms Wild has been battling for the top spot in the New Brunswick-Prince Edward Island Major Midget Hockey League all season.
The Wild (23-10-0-2,48 points) was in first place and awaiting the results from the final game of the regular season Friday night to see if they won the league title.
Third-place Fredericton Caps (19-9-0-6, 44 points) travelled to second-place Saint John Vitos (23-11-0-0, 46 points) Friday. A Saint John loss or tie would give Kensington the league title.
The Charlottetown Robins Donuts Islanders are the other Island entry in the six-team league and they are in last place, trailing Moncton and Miramichi.
The winner of the provincial series between Kensington and Charlottetown, which opens next Saturday in Kensington, will advance to the Atlantic tournament. The Telus Cup is the national prize for major midget teams.
Wild head coach Kyle Dunn and his assistants Matt Fortier and Duane Richards have earned quite a reputation in minor hockey, especially for their handling of young players and getting the best out of them.
This is the second year for this coaching staff, although Fortier and Richards were with Mark Carragher two years ago when he was head coach in Kensington.
A look at the league standings and scoring race suggests Dunn and his assistants have put together a solid club. Brodie MacArthur won the scoring race with 20 goals and 40 assists and the youngster didn't look out of place when he jumped up to the Quebec major junior league against the Islanders here a month ago.
Brodie's linemate T.J. Brodie (18-36, 54) is second in the league, Frank Fortin (24-17,41) leads the loop in goals and Kyle Pinksen (23-17, 40) is second in making the red light blink. Isaac Knox (12-19,31), Jordan's younger brother, and Brendan Shea (13-17, 30) are among the top 20.
The defence recently added 15-year-old Chris McQuaid, who played the first half season in Austria but wanted to return home for a shot at the Telus Cup. He has size, skating ability and has a cannon, which suggests he'll be an early round major junior draft pick. Another good defenceman is Cornwall's Ryan Boswall. Besides these two, the Wild have talented Lucas Beaulieu, first-year Clark Webster, whose brother Bailey plays with Saint John in the Quebec league, and reliable Jack Desroches.
Jesse Jay is a stay-at-home defender with an interesting pedigree. He's the grandson of Island hockey great Angie Carroll.
Luke Oliver is one of the top goaltenders in the league and if he stays hot, the Monaghan Farm boys just might land in the Telus Cup, hosted by Saint John.
A good number of these youngsters will be drafted by Quebec major junior clubs, so let's hope the Charlottetown Islanders get a long look at our boys.
The UPEI hockey Panthers surprised a lot of people with that 6-3 road win Wednesday in Wolfville, N.S.
Although outshot 37-21, Panthers goaltender Mavric Parks was sharp and the Panthers made the most of their chances. The over-achieving Panthers simply outwork other clubs, hopefully it continued Friday.
Harness racing
Local harness racing is dark but simulcast is available from all major tracks.
At Woodbine tonight, the four-year-old mares final goes for $44,000.
At Yonkers, N.Y., Mark MacDonald drives Bad Boy Matt in the $32,000 top class and Swishnflick in the $32,000 open trot.
At the Meadowlands, Limelight Beach has the eight-hole in the $20,000 top class.
At Pompano Park, Arthur Blue Chip was second in 1:51 in the top class last Sunday but he's not in this week. The situation in Florida is troubling with the de-coupling issue a threat to live racing.
Fred MacDonald's column appears every Saturday in The Guardian. He can be reached at email@example.com.
A look at the best-of-seven Prince Edward Island major midget final:
Saturday, Feb. 27
7:30 p.m. – Charlottetown at Kensington.
Sunday, Feb. 28
1:45 p.m. – Kensington at Charlottetown.
Saturday, March 5
7:30 p.m. – Charlottetown at Kensington.
Sunday, March 6
1:45 p.m. – Kensington at Charlottetown.
Saturday, March 12
7:30 p.m. – Charlottetown at Kensington.
Sunday, March 13
1:45 p.m. – Kensington at Charlottetown.
Saturday, March 19
7:30 p.m. – Charlottetown at Kensington.


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GENERAL: Co-captain...southpaw who is expected bring veteran leadership to the starting rotation again... crafty starter with good experience under his belt... product of a top CHSAA program... possesses good knowledge of the game.
2009: MAAC Pitcher of the Year... selected to MAAC All-Tournament Team...posted a 7-1 overall record and was 5-0 in MAAC contests... registered a team-best 4.15 ERA... logged a 3.75 ERA in league contests... delivered four complete game efforts in wins over Temple (3/13, Marist (4/4), Rider (5/9), and Rider (5/21) in the opening contest of the MAAC Tournament... twirled nine dominant innings allowing just one earned run and five hits in a 2-1 postseason victory over Rider at Waterfront Park in Trenton, N.J... named MAAC Pitcher of the Week on March 16... Manhattan went 11-2 in 13 games started... notched a season-high eight strikeouts in a win over Marist (4/4)... struck out 54 batters and yielded a .256 batting average against... tossed seven shutout innings in a victory over Canisius (4/25)... walked just 43 batters in 93.1 innings of action.
2008: MAAC All-Academic selection... posted a 4-3 record with 4.35 ERA over 12 appearances... started five games during the regular-season... named MAAC Pitcher of the Week on May 5... registered 35 strikeouts over 41.1 innings of action... harbored a 2.82 ERA during the regular season... earned wins versus Niagara (4/12), Marist (5/3), Saint Peter's (5/11) and Fairfield (5/14)... allowed just two earned runs over last 18 innings pitched during the regular season... tallied a season-high five strikeouts twice (5/11 & 5/15)... yielded a .268 batting average... played summer ball for Peekskill Robins of the Atlantic Collegiate Baseball League.
2007: Appeared and started five games before suffering season-ending injury... granted a medical red-shirt... worked 19.2 innings... longest outing was 6.1 innings at Liberty (3/3), tallying three strikeouts... a MAAC All-Academic selection.
2006: Appeared in 14 games, making eight starts... posted a 4-4 record with a 4.86 ERA... struck out 52 batters in 46.1 innings of work... named MAAC Pitcher of the Week on April 23 and May 14... made collegiate debut at #15 Tulane (3/4)... made first collegiate start at Fordham (5/3)... picked up first collegiate win vs. Siena (3/25), striking out nine over 6.2 innings... did not allow a run while posting seven strikeouts over 6.0 innings in win over Lehigh (4/19)... tallied a season-high 11 strikeouts in win vs. Columbia (4/26)... worked 2.0 innings against Miami (6/3) at the NCAA Regional... played his summer baseball for the Manchester Silkworms of the New England Collegiate Baseball League (NECBL).
BEFORE MANHATTAN: Team won Catholic High School Athletic Association (CHSAA) Championship in 2003... named All-Westchester County First Team... received All-Bronx/Westchester First Team recognition... honored as All-CHSAA and All-City Honorable Mention.. selected to New York All-State Fifth Team in 2004.
PERSONAL: Majoring in business... the son of John and Dianne Gazzola... has three siblings, John, Chris, and Meghan.
|Left-Handed Pitcher
|White Plains, N.Y.
|High School:
|Iona Prep


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AstolatModel Female London, England, United Kingdom
My MM URL: http://www.modelmayhem.com/astolat
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About MeNOTE - I have a new haircut, 70s/retro style with a fringe. I have no shoot pictures with this style, but if you're interested in collaborating, get in touch and I can send you an image of the new style!
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I live in London, and am very flexible for shoots, but if you want to do a shoot further afield, I am always more inclined to work with people who offer travel expenses.
Agency signed and especially interested in paid hair shows, but I always consider other shoots too!
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text:
Russia is again singled out, as a country whose government is allegedly taking aggressive measures to curb media freedom.
In its recently published annual study, the US-based Freedom House suggests that Vladimir Putin's policies have been a "template" for repressive governments the world over.
It asserts that Russia's once "lively and probing" press, has been turned into "a toothless sounding board" for official opinion.
The Russian government counters such accusations by pointing to the thousands of non-state publications.
Generally, Russian officials react extremely badly to suggestions that their country ranks alongside Burma, Cuba and North Korea, for media freedom. They insist that there is a genuine pluralism of opinion - in the printed media, at least.
However, television remains the predominant source of information for the majority of Russians. And it does not allow opposition voices to be heard.
Many Russia-watchers have followed the change of tone and content of state television over recent years.
Shift to 'positive' news
Increasingly, hard-hitting investigative journalism has been replaced by Soviet-style "razoblacheniya" - or exposes. They often look crude and carry unsubstantiated allegations.
Read the findings
Global press freedom 2007: selected data [256KB]
In addition, any form of satire aimed at the president or his closest associates seems to be totally forbidden.
Equally, there is an obvious shift in favour of "positive" news, presenting an optimistic picture of Russian life, especially when compared to events in the neighbouring countries, which are often portrayed as unstable.
The governments of some of those countries - especially Ukraine, Georgia, and, most recently, Estonia - complain that Russian state television sometimes broadcasts allegations that are simply untrue, and which exacerbate xenophobic sentiments.
Two weeks ago, Russian police and the FSB (internal security service) raided the offices of Educated Media Foundation (EMF), the main partner of the California-based InterNews Network.
Investigators have brought criminal charges against the organisation's director, Manana Aslamazyan, who had failed to declare 9,500 euros on a customs form.
Lawyers say she acknowledges her error, but insist that it should in no way serve as a justification for the raid on, and subsequent closure of, EMF.
Foreign cash
In an unprecedented response, nearly 2,000 Russian journalists, including many household names, have signed an open letter deploring the authorities' action as "another step infringing on the civil rights enshrined in the Russian Constitution".
The letter called on President Putin to intervene personally, to prevent the "destruction" of an organisation it described as producing "the pride of Russian television".
There seems to be little realistic chance of that happening. In his recent - and probably final - address to parliament, the Russian leader warned of "ever-increasing flows of cash from abroad", allegedly being used to finance opposition groups.
Media freedom groups warn that the Russian government may soon take measures to regulate the internet. Access is growing very quickly in Russia, there are thousands of ISPs, and content is not, so far, controlled by the government.
Last month, President Putin signed a decree establishing a new body to supervise the mass media and internet content. Officials insist it will be in charge of licensing, rather than regulating, what's available.
But Russia's parliament - which critics say rubber-stamps President Putin's proposals - is considering ways of clamping down on "extremism" on the internet.
And in Russia, the concept of "extremism" has been widened significantly, beyond the initial intention of tackling violent racists and neo-Nazis. Increasingly, the mainstream opposition finds itself branded "extremist".
Contract-style murders
Some of Russia's leading online journalists say the government will not succeed in controlling the internet, if that is its intention. They point to the failure of similar measures abroad, especially in China and Turkey.
To be fair, there are newspapers in Russia - Novaya Gazeta, and Kommersant, among others - that carry considered, informed, balanced writing. Their readerships are not large - perhaps in the tens of thousands.
But they do put Russia in a different league than North Korea or Turkmenistan.
This said, Russian liberals warn that, in the current atmosphere, critical journalists are increasingly likely to be targeted for physical retribution.
Russia is acknowledged to be a dangerous place to be a journalist, with very few of the contract-style murders of journalists in recent years resulting in a conviction.
What are these?
Most Popular Now | 56,514 people are reading stories on the site right now.";


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Congratulations on Zonterest. It's sheer geniusSteve Shaw


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Department of Chemistry
Florida Campus
Laboratory Website
Scripps VIVO Scientific Profile
(561) 228-2203
Faculty, Graduate Program
The Disney group is focused on developing rational and predictable approaches to design highly selective therapeutics from only genome sequence. One of the major articulations of the utility of genome sequencing efforts has been in advancing patient-specific therapies, yet such developments have been only sparsely reported.
We accomplish this lofty goal by using advancements in annotating RNA structure from sequence and several novel technologies that we have recently developed in our laboratory. Our current focus is on leveraging these technological advances to identify patient-specific therapies targeting orphan diseases that have no known cure or more common disorders to which there is a poor prognosis, such as drug resistant cancers.
Key advances that we have recently reported include:
(i) Developing lead therapeutics that improve defects associated with the most common adult-onset forms of muscular dystrophy (Myotonic Dystrophy Types 1 and 2) in both animal and cellular models of disease.
(ii) Designing compounds that target the most common single gene cause of Autism (Fragile X Syndrome) and an adult-onset disease called Fragile X-Associated Tremor Ataxia Syndrome that occurs in older individuals that carry a shortened version of the Fragile X Syndrome genetic defect. These studies have advanced our understanding of novel roles of RNA-mediated gene silencing and in identifying and exploiting novel drug targets.
(iii) Targeting the genetic defect that causes Huntington's disease, which is an incurable disorder that causes muscle decline and cognitive issues.
(iv) Correcting RNA processing defects that are caused by RNA mutations in Parkinsonism and Frontotemporal Dementia (FTDP-17).
(v) Developing specific lead therapeutics that reduce the production of toxic proteins that are known to cause the majority of cases of Amyotrophic Lateral Sclerosis (ALS, Lou Gehrig's disease) and Frontotemporal Dementia
(vi) Designing precise therapeutics that specifically kill a variety of Cancers that have a poor prognosis with current chemotherapeutics
(vii) Exploiting important classes of drug targets in multiple disorders that are viewed as being impossible to "drug"
(viii) Developing and implementing novel technologies that allow for the precise reaction and cleavage of RNA targets by using small molecules to both identify and further manipulate therapeutically relevant RNAs by small molecules.
Ph.D., Biophysical Chemistry, University of Rochester, 2003
B.S., Chemistry, University of Maryland, College Park, 1997
M.S., Chemistry, University of Rochester, 1999
2005-2010 Assistant Professor, University at Buffalo, The State University of New York
2002-2005 Postdoctoral Fellow, Swiss Federal Institute of Technology Zurich (ETH)
1995 – 1997- Howard Hughes Medical Institute Undergraduate Research Fellow; University of Maryland, College Park.
1997- Eric A. Batista Award; University of Maryland, College Park. Award for most outstanding undergraduate research.
1997 – 1999 - Sherman-Clark Memorial Fellow; University of Rochester.
2000 – 2001 - Elon Huntington Hooker Memorial Fellow; University of Rochester.
2001 – 2002 - Arnold Weissberger Memorial Fellow; University of Rochester.
June 2003 – May 2004 - Roche Foundation Post doctoral Fellowship; Swiss Federal Institute of Technology (ETH, Zürich).
June 2004 – January 2005 - Second Year Roche Foundation Post doctoral Fellowship; Swiss Federal Institute of Technology (ETH, Zürich).
September 2005 – August 2010 - Camille and Henry Dreyfus New Faculty Award.
July 2007 – June 2009 - NYSTAR JD Watson Young Investigator Award.
July 2008 – June 2010 - Research Corporation Cottrell Scholar Award.
May 2010 – April 2015 - Dreyfus Teacher-Scholar Award.
May 2010 - University at Buffalo, Excellent Scholar, Young Investigator Award.
2012 - David Gin Award in Carbohydrate Chemistry from the American Chemical Society in recognition of excellence in carbohydrate chemistry from a new investigator.
2013 - Eli Lilly Award in Biological Chemistry from American Chemical Society in recognition of outstanding research in biological chemistry of unusual merit and independence of thought and originality.
Su Z, Zhang Y, Gendron TF, Bauer PO, Chew J, Yang W-Y, Fostvedt E, Jansen-West K, Belzil VV, Desaro P, Johnston A, Overstreet K, Boeve BF, Dickson D, Floeter MK, Traynor BJ, Morelli C, Ratti A, Silani V, Rademakers R, Brown RH, Rothstein JD, Boylan KB, Petrucelli L*, Disney MD*. Biomarker and lead small molecule discovery to target r(GGGGCC)-associated defects in c9FTD/ALS. Neuron, in process.
Rzuczek SG, Park H, Disney MD. A toxic RNA catalyzes the in cellulo synthesis of its own inhibitor. Angewandte Chemie, in press.
Luo Y, Disney MD. Bottom-up design of small molecules that stimulate exon 10 skipping in mutant MAPT pre-mRNA. ChemBioChem, in press.
Promoter-bound trinucleotide repeat mRNA drives epigenetic silencing in Fragile X syndrome. Colak D, Zaninovic N, Cohen MS, Rosenwaks Z, Yang W-Y, Gerhardt J, Disney MD, Jaffrey SR. Science, 2014, 343:1002-1005. PMID: 24578575.
Targeting the r(CGG) repeats that cause FXTAS with modularly assembled small molecules and oligonucleotides. Tran T, Childs-Disney JL, Liu B, Guan L, Rzuczek S, Disney MD. ACS Chemical Biology, 2014, 9:904-912. PMID: 24506227.
Two-dimensional combinatorial screening enables the bottom-up design of a microRNA-10b inhibitor. Velagapudi SP, Disney MD. Chemical Communications, 2014, 50:3027-3029. PMCID: PMC4040211.
Sequence-based design of bioactive small molecules that target precursor microRNAs. Velagapudi SP, Gallo SM, Disney MD. Nature Chemical Biology, 2014, 10:291-297. PMCID: PMC3962094.
Myotonic Dystrophy Type 2 RNA: Structural Studies and Designed Small Molecules that Modulate RNA Function. Childs-Disney JL, Yildirim I, Park H, Lohman JR, Guan L, Tran T, Sarkar P, Schatz GC, Disney MD. ACS-Chemical Biology, 2014, 9:538-550. PMCID: PMC3944380.
Methods to enable the design of bioactive small molecules targeting RNA. Disney MD, Yildirim I, and Childs-Disney JL. Organic and Biomolecular Chemistry, 2014, 12:1029-1039.
A chemoenzymatic route to diversify aminoglycosides enables a microarray-based method to probe acetyltransferase activity (Cover article). Tsitovich PB, Pushechnikov A, French JM, Disney MD. Chembiochem 2010, 11:1656-1660.
Structure-activity relationships through sequencing (StARTS) defines optimal and suboptimal RNA motif targets for small molecules. Velagapudi SP, Seedhouse SJ, Disney MD. Angew Chem Int Ed Engl. , 2010, 49:3816-3818.
Controlling the specificity of modularly assembled small molecules for RNA via ligand module spacing: targeting the RNAs that cause myotonic muscular dystrophy. Lee MM, Childs-Disney JL, Pushechnikov A, French JM, Sobczak K, Thornton CA, Disney MD. J Am Chem Soc., 2009, 131: 17464-17472.
Rational design of ligands targeting triplet repeating transcripts that cause RNA dominant disease: application to myotonic muscular dystrophy type 1 and spinocerebellar ataxia type 3. Pushechnikov A, Lee MM, Childs-Disney JL, Sobczak K, French JM, Thornton CA, Disney MD. J Am Chem Soc. 2009 Jul 22:131(28):9767-79.
Podcast on rational design of small molecules targeting RNAs that cause incurable disease
Rational design of small molecules targeting incruable disease II
Rational design of small molecules targeting incruable disease
Highlight of our work on targeting toxic RNAs III
Highlight of our work on targeting toxic RNAs II
Highlight of our work on targeting toxic RNAs
Highlight on our work to target RNA Defects in Huntington's and other diseases
Podcast on our work on developing drugs for Myotonic Muscular Dystrophy
Letting the Drugs Have Their Say


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What are the important events that happened on October 6, 1956? Here are historical events, facts, and some myths about this day.
October 6, 1956: Facts & Myths About This Day
October 6, 1956 is the 280th day of the year 1956 in the Gregorian calendar. There are 86 days remaining until the end of this year. The day of the week is Saturday.
Under the Julian calendar, this day is September 23, 1956 – a Saturday. Both day of the week are the same but did you notice the difference with the Gregorian calendar?
Strange as it may, if we name this day after a polygon then it will be called 'dihectaoctacontagon' day.
Hey! How's your life today? Get the Life Destiny Report and gain a deeper understanding of yourself. Try it today and improve your life. (Sponsored link)
If a person born on this day saved a Cent every day starting at age 3, then by now that person has accumulated $211.11. (Assuming this person is still alive today.)
Libra is the zodiac sign of a person born on this day. Opal is the modern birthstone for this month. Jasper is the mystical birthstone from Tibetan origin that dates back over a thousand years.
Monkey is the mythical animal and Fire is the element for this person if we consider the very old art of Chinese astrology.
Curious to find out some fun birthday facts about October 6, 1956? Listen to the number-one song on the day you were born. Find out what your birthday means! (Sponsored link)
Who were born on October 6, 1956?
- 1956 –Kathleen Webb, American comic book writer and artist
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Lillian D. Wald (1867-1940)
Social reformer and advocate for the poor, Lillian D. Wald was born in 1867, in Cincinnati, Ohio. In 1891, she graduated from the New York Hospital Training School for Nurses and then took courses at the Woman's Medical College. She worked at the New York Juvenile Asylum and helped with a class about home nursing for poor immigrant families in New York's Lower East Side. Wald's work in the area prompted her to move there to be a visiting nurse and help aid the families who were living in horrible conditions. After gaining a sponsor, Wald's practice grew as did her staff, which by 1913 had grown to 92 people. She worked in the area for forty years. Her practice became the Henry Street Settlement and then turned into the Visiting Nurse Service of New York City.
Wald was influential in advocating for nurses at public schools and her idea led to the New York Board of Health organizing and running the first public nursing system in the world. As first president of the National Organization for Public Health Nursing, Wald suggested a national health insurance plan. She also helped found Columbia University's School of Nursing.
Wald was not content to simply help improve the immigrant's health through nursing but also taught the women how to cook and sew and provided recreational activities for the families. In 1915, Wald founded the Neighborhood Playhouse to serve as a cultural center.
Wald's humanitarian efforts extended beyond helping poor immigrants adjust to their new country and live in sanitary conditions. She was involved in a variety of causes and always fought for justice and fairness. Wald helped establish the United State Children's Bureau and lobbied for years for the end of child labor laws, allowing all children to attend school. She helped President Theodore Roosevelt create the Federal Children's Bureau. Wald advocated for education of the mentally handicapped. As an active campaigner for civil rights, Wald insisted that all Henry Street classes be racially integrated. In 1909, she helped to establish the National Association for the Advancement of Colored People. Wald also advocated for woman suffrage and for peace. She marched in protest of the United States' entry into World War I, joined the Woman' Peace Party and helped establish the Women's International League for Peace and Freedom.
In 1922,Wald was nominated on The New York Times' 12 greatest living American women, and although she did not make the final list, she later received the Lincoln Medallion for her work as an "Outstanding Citizen of New York." Wald died in 1940, having changed the world for the better in countless ways.
Additional Resources:
Web Sites:
- Henry Street Settlement
- Jewish Women's Archive Biography
- Jewish Women's Archive Research
- Lower Manhattan
- National Women's Hall of Fame
- Brody, Seymour. Jewish Heroes & Heroines of America: 150 True Stories of American Jewish Heroism. Floriday: Lifetime Books, Inc., 1996.
- Coss, Claire. Lillian D. Wald: Progressive Activist. New York: The Feminist Press at CUNY, 1989.
- Daniels, Doris Groshen. Always a Sister: The Feminism of Lillian D. Wald. New York: The Feminist Press at CUNY, 1995.
- Eiseman, Alberta. Rebels and reformers: Biographies of four Jewish Americans: Uriah Philips Levy, Ernestine L. Rose, Louis D. Brandeis, Lillian D. Wald. Zenith Books, 1976.
- Wald, Lillian D. The House on Henry Street. Transaction Publishers, reprint edition, 1991.


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Cholesterol is a chemical compound produced naturally by the body which made up of a combination of lipid (fat) and steroid. Cholesterol is a building block for cell membranes and for hormones like estrogen and testosterone. While only a small amount comes from diet, around 80% of the body's cholesterol is produced by the liver. After a meal, dietary cholesterol is absorbed from the intestine and stored in the liver. The liver regulates cholesterol levels in the blood stream and can secrete cholesterol if it is needed by the body.
LDL cholesterol is known as "bad" cholesterol because elevated levels of LDL cholesterol are linked with an increased risk of heart disease, stroke, and artery disease. This bad cholesterol deposits cholesterol along the inside of artery walls, resulting in the formation of a hard, thick substance called cholesterol plaque. Over time, cholesterol plaque causes thickening of the artery walls and narrowing of the arteries (a process called atherosclerosis) which reduces blood flow through the constricted area.
HDL cholesterol is known as the "good cholesterol" because HDL cholesterol particles reverse the process of atherosclerosis by extracting cholesterol from the artery walls and disposing of them through the liver.
High levels of LDL cholesterol and low levels of HDL cholesterol (high LDL/HDL ratios) are risk factors for atherosclerosis, whilst low levels of LDL cholesterol and high levels of HDL cholesterol (low LDL/HDL ratios) are desirable and protect against heart disease and stroke.
© 2012 | All Rights Reserved | Richmond Pharmacology Ltd


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Kohl Christian Thomas Patton graduated Jan. 17 from U.S. Marine Corps boot camp at Parris Isand, S.C
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Perry, Romney and others wrangle over immigration in debate
ORLANDO – Call it a Sunshine State smackdown.
In the third Republican presidential debate in three weeks, immigration joined Social Security as an issue creating fireworks between the two men leading in national polls.
Former Massachusetts governor Mitt Romney accused Texas Gov. Rick Perry of creating a "magnet" in Texas for illegal immigrants by offering in-state tuition at colleges for children regardless of their immigration status.
"That shouldn't be allowed," Romney said. "It makes no sense at all."
Perry, drawing boos from an audience of 5,000 at the Orange County Convention Center, defended the Texas law. "If you say we should not educate children who come into our state … by no fault of their own, I don't think you have a heart," he replied.
Nine GOP presidential contenders bashed President Obama, vowed allegiance to the Constitution's 10th Amendment on states' rights and detailed the federal department they would most like to eliminate in a two-hour debate sponsored by Fox News and Google.
Former Pennsylvania senator Rick Santorum joined Romney in attacking Perry on immigration, and businessman Herman Cain spoke with emotion about his battle with cancer. Former Utah governor Jon Huntsman suggested the other candidates could rise and seize the nomination because the two contenders at the center of the stage "might bludgeon each other to death."
From the start, however, the spotlight was on Perry and Romney, and the other candidates sometimes struggled to get in the conversation.
The Texas governor, who shot to the top of national polls soon after joining the race six weeks ago, was on the defensive for much of the evening, batting back criticism on Social Security, immigration and his lack of a specific jobs proposal.
Toward the end of the two-hour debate, he seemed to flag, and his position on immigration put him at odds with his Republican base.
Romney was direct, confident and prepared, showing the benefits of his debate experience in two presidential runs. He sometimes simply deflected Perry's attacks by replying, "Nice try" before moving on to make his preferred point. "I don't think he knows what he's talking about in that regard," he said when asked about Perry's criticism that he is "Obama-lite" because of the health care law he signed.
He suggested Perry was a career politician. "I was in government four years," he said. "I didn't inhale."
They each hit on what are likely their biggest vulnerabilities: Perry's suggestion in his 2010 book that Social Security was unconstitutional and should be administered by the states, and Romney's signature on a Massachusetts health-care law similar to Obama's federal program.
Romney said Perry was trying to back away from what he wrote just six months ago. "There's a Rick Perry out there" espousing that, Romney said to laughter. "You better find that Rick Perry and get him to stop saying that."
An hour later, Perry turned a similar charge against Romney. "I think Americans just don't know sometimes which Mitt Romney they're dealing with," he said, saying Romney had changed positions on gun control and abortion rights. "I mean, we'll wait until tomorrow and see which Mitt Romney we're really talking to tonight."
He attacked Romney as an unreliable conservative and accused him of trying to back away from the Massachusetts health care law
Four months before the Iowa caucuses, the Republican field is beginning to coalesce. Perry and Romney led the GOP field, at 31% and 24% in a USA TODAY/Gallup Poll taken last weekend. Paul was the only other candidate in double digits, at 13%.
Also participating were Minnesota Rep. Michele Bachmann, Texas Rep. Ron Paul, House speaker Newt Gingrich and former New Mexico governor Gary Johnson.
Bachmann was struggling for traction just six weeks after she won the Iowa straw poll, only to see Perry peel away support among conservative evangelicals and Tea Party supporters. She was at 5% in the USA TODAY survey, tied with Gingrich and Cain.
She urged conservatives not to "settle" for a candidate who didn't share their values, saying Obama hadn't hit "the basement" yet. "That's why we need to choose a candidate who represents conservatives and constitutional conservative positions," Bachmann said.
Earlier in the day, at the Florida Faith and Freedom Coalition meeting, Santorum took a similar tack, urging religious conservatives to look at the Republican contenders' records. "Don't just look at what box they check, what pledge they take; take a look at what bullets and arrows they've taken for the causes they believe in," he said.
In the debate, Perry was asked about his relationship with former president George W. Bush, with whom he shares a Texas drawl but has had sometimes prickly relations. "We've got a great rapport," Perry said, saying the two men talk on "a relatively regular basis."
Still, he noted that he had been "very vocal" in disagreeing with Bush on creating the Medicare Part D drug benefit and on the No Child Left Behind education law. "It gets back to the federal government has no business telling states how to educate our children," he said.
There's still time for the Republican standings to shift, of course. Four years ago this month, former New York mayor Rudy Giuliani was at the top of the Gallup Poll at 30%, followed by former Tennessee senator Fred Thompson at 22%. The eventual nominee, Arizona Sen. John McCain, trailed in third place at 18%.
Even so, history indicates that the hurdles are high for contenders who haven't broken into double digits by now. In the past two decades, only once has a candidate who was in single digits at this point ended up winning the nomination. (That was Democrat Bill Clinton in 1992.)
Johnson, at 1% in some national polls, drew hoots of laughter with a jab at the White House economic policy.
"My neighbor's two dogs have created more shovel-ready jobs than the president of the United States," he said.
Within minutes on Twitter, debate-watchers noted that was a slightly-modified version of a joke Rush Limbaugh had used on his talk-radio show earlier in the day.
Posted | Updated


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Madonna has two tickets to the gun show
If you're like me, you lie awake at night wondering if Madonna's arms are still continuing their trek to becoming emaciated pythons of doom. Look no further, friend. To be honest, I'm glad she's on our side. If danger ever sets foot in America, I know Madonna will unleash her Kaballah uppercut and send those terrorist bastards into orbit. Provided we always have dinner on the table and don't ask where she goes at night. (Hint: Underground arm wrestling competitions – with cyborgs.)


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The Evolution Of The Customer Engagement Agency
February 13, 2012
Why Read This Report
As the demand for customer intelligence (CI) from business stakeholders grows and more organizations increase their CI maturity, organizations' marketing agency needs have also changed. A few traditional marketing services providers have recognized this need and are investing in services ranging from strategy development to creative execution to media buying. In this report, we explore the evolution of this model and provide a look ahead at the new customer engagement agencies.
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A: Most of us know that the days (in the Northern Hemisphere) begin growing longer after the winter solstice, which falls on Dec. 21 or 22 most years in most time zones. (Related question and answer: Does winter really begin on Dec. 21 or 22?)
But, few people notice something unusual, sunrise does not occur earlier until well after the solstice. That is, until well into January the days grow longer because sunset is a little later each day while sunrise might actually occur later or hold at the same time for several days.
Exactly what happens depends on your latitude; that is, how far north of the equator you are.
The U.S. Naval Observatory table for sunrise and sunset times in Indianapolis shows that the sun rises there at rises at 8:03 a.m. and sets at 5:24 p.m. on Dec. 22. By Dec. 25, the sun rises at 8:04 and sets at 5:26. On Dec. 26, 27, 28, and 29 the sun rises at 8:05 but the sun rises a minute later each day. From Dec. 30 through Jan. 10 the run rises at 8:06 a.m. each day, but the time of sunset changes from 5:29 to 5:39 during this period. Finally, on Jan. 11, the run rises a minute easier than the previous day and rises earlier just about each day from then through June 20. (Related resources: Sun, moon, stars, time)
Why this occurs goes back to a couple of things.
• First, the Earth is nearest to the sun in January and is moving faster in its orbit around the sun than at other times of the year.
• Second, our 24-hour day is based on the average time it takes the Earth to spin once on its axis as measured from when the sun is highest in the sky (local noon) one day until noon the next day.
In very simple terms, at different times of the year, time as we measure it by clocks and the movement we see of the sun across the sky grow out of alignment. In effect, this is most noticeable - to those who notice such things - around this time of the year.
Instead of trying to explain the details of what's going on, I'll send you to some Web sites that have good answers. Just follow the links below.
• NASA Ask a High-Energy Astronomer: The equation of time.
• U.S. Naval Observatory: The dark days of winter.
• Staryskies.com: The latest sunrise and the equation of time
• Keith C. Heidorn, The Weather Doctor:Entering the Dark Days.


text: Tiny Turtles, Big Problems By Scott Weese on May 20, 2016 Posted in Reptiles, Salmonella The CDC has updated information on the ongoing (if not ever-present) salmonellosis outbreaks linked to pet turtles. At last count, there were 133 illnesses (although it's likely that this represents a fraction of the people that actually got sick), with 38 of those requiring hospitalization. Forty-one percent (41%) were kids under the age of five, reflecting… Continue Reading


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Hi There,
I'm hoping someone can help me with my question.
I've interviewed a doula who I feel like I really clicked with, she seems perfect! However, my only aprehension is that she told me she has another client due a week before me, and since the other client hired her first, that if I were in labor, and the other woman went into labor after me, she would call in her back up for me, and have her transition in so my doula could go to the other laboring woman. I was under the impression that whoever calls first would have priority with doulas, but I'm not sure. She only takes two clients a month, and said she has never had to call a back up. Other than this, I really like her and feel excited to work with her, I know its probably totally unlikely that we would be in labor at the same time, I just feel a little nervous about the possibility. What do you think?
If you really like her, I would go ahead and hire her. Even if you find another doula you like, it is probable she will take on more than 2 births a month, in which case you have a higher chance of ending up with a back-up. Like you said it is highly unlikely.
We have a month-long window for what is considered "normal", that is 720hrs of potential labor time... if she spends an average of 15hrs per woman and your dates are a week apart that is literally hundreds and hundreds of hours for you to have your baby with your doula all to yourself :) Happy birthing!
Amara ~ Married to my HS sweetheart, we're having a blast with baby Z (1/29/2011)
If she is anything like me, she did not just pick a random doula to be her back-up. Momma's feelings are top priority to us doulas! Ask if you can meet with the back-up ahead of time. Hopefully you will find that she is very similar to your doula!
Happy birthing, and congratulations!!
Loving being an artist, photographer, and bookworm.
Last time I used shampoo: March 13, 2012. Go No 'Poo!
Crunchy momma in training Still waiting for my BFP.
RIP to my brother, who went to be with God after battling sarcoma 5/26/87-11/1/07
Married to my favorite person (together since '01, married since '05), the hapa papa to my queeuty quapa DD, born 10/11.
We baby wear, co-sleep, cloth diaper, don't vax and intend to nurse for a good long time.
I don't care what you do as long as it works for your family.
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We've heard a million times the phrase that boasts "real men wear pink." Personally, I'd like to believe that this rule of thumb applies not only to pink, but to every other so-called "feminine" aspect of fashion. In this age and time where lines are constantly blurred and boundaries are crossed almost every day, are we really still classifying pink as a girl's color and guys who dress well as metrosexuals? I think not!
This Fashionisto stood out from the crowd as he rocked a very casual look featuring a beautiful unbuttoned floral shirt paired with a basic crewneck T-shirt inside. If there's one trend that only a true Fashionisto or Fashionista can pull off, it's the "it took a lot of time to look this casual" look—a man's equivalent to our "no-makeup makeup look."
With the fashion boom creating a wave of style-conscious people everywhere, it can be hard to stand out in a crowd that gravitates towards bright fluorescent neons and metallics. Especially when most of these pieces can be blinding from a mile away! Hence, there is much respect and admiration for a person who maintains his or her own personal style without feeling the need to flock to the first fad that pops up.
This Fashionisto seems to master the key to working understated styles into his look by ticking the boxes in all the right places. Lazy beanie: check; funky glasses: check; open-laced derbies: check; cropped skinny pants: check; invitation to the best dressed list: check and check.
By focusing on understated statements throughout his outfit, he allows more space to explore different trends at the same time. Instead of looking to make all aspects of his outfit stand out, this Fashionisto understands that it has always been quality over quantity. To avoid overpowering your look with more than one statement piece, stick to working one and working it good.
On a side note, it is so refreshing when people don't wear socks. Socks have never made a big appearance on the fashion horizon so now that people are finally starting to embrace the "no socks" trend, I really couldn't be more ecstatic. The trend is extra stylish when it comes to cropped pants as it creates a classic preppy look with an edgy twist.
In the future, remember — metallic and pastel trends may come and go, but nothing looks better than being yourself and working your own personal style. Not everything has to be a statement! After all, the key is in the details.


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Waterworks McDonald's opening means more jobs for Fox Chapel Area students
In just five days — and one minute — the golden arches will open at The Waterworks.
Big Macs and fries will be served starting at 12:01 a.m. June 19 at the first McDonald's ever to open in the Lower Valley.
The store sits along Freeport Road, sandwiched between Wendy's and Walnut Grill.
"For many years, residents across the Allegheny Valley have been asking us to raise the Golden Arches in this area," said owner Michael Delligatti, son of Fox Chapel resident and creator of the Big Mac, Jim Delligatti.
It was Jim Delligatti who brought the first McDonald's to the western Pennsylvania region, opening a store along McKnight Road in 1957.
The new restaurant is expected to create more than 85 jobs, with at least one-fourth of those specifically for Fox Chapel Area High School students.
"They came to our career fair and then followed the next week at school to do interviews and complete applications," said John Baxter, district coordinator of career development.
As of last week, there were 20 district students hired to be cashiers, maintenance workers, fry cooks and more.
Baxter said an additional crew of students will be approved for co-op work experience where they will be released early from school to work a part-time shift at the restaurant. Students earn school credits for their time spent working.
"A fast food place is a great way to start learning how to work with people," Baxter said.
Realizing that students are busy with extra-curricular activities, Baxter said McDonald's staff has worked to provide flexible work schedules.
They also provided Baxter and teacher Justin Papariello with an overview of the organization's training program to share with students.
"They walked us through from the point of being hired as a high school worker at 15, all the way to management training," Baxter said.
The Waterworks McDonald's becomes the newest in the country, joining some 34,000 sites in 110 countries across the world. Contractors were busy this week putting the finishing touches on the restaurant, planting shrubs to line Freeport Road and erecting the Neon yellow sign near the entrance.
The site is one of 21 restaurants owned by Delligattti's M&J Management, a three-generation business.
It was built with an eco-friendly model, using all LED lighting in the parking lots and exterior signs. The building has a white reflective roof to help save on cooling energy and includes digital menu boards.
Tawnya Panizzi is a staff writer for Trib Total Media. She can be reached at 412-782-2121, ext. 2 or firstname.lastname@example.com.


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Transformers: Age Of Extinction Character Posters Land
Update: Now with added Optimus Prime and Nicola Peltz
Update: the poster roster now stands at four, with Nicola Peltz's Tessa and main robo-man himself, Optimus Prime, added to the group.
"The Rules Have Changed" squawk the new character posters for Transformers: Age Of Extinction, and we're pretty sure they don't mean the rules of Bridge - unless the new rule is Blow Up All The Bridges, a Michael Bay trademark. It's all in aid of putting our minds back in a Bayhem mood ready for the new trailer headed our way shortly.
The fourth film in the franchise is something of a fresh start, and sees an Earth scarred by the events of the last three films but moving on after the disappearance of all giant robots. Will they stay away for long? You do know the movie's still called Transformers, right? And not Mark Wahlberg Eyes His Car Suspiciously But Nothing Really Happens? Did you watch the Super Bowl spot? {New Transformers: Age Of Extinction Stills}
When Wahlberg's inventor, Cade Yeager, discovers a buried Transformer, the stage is set for the return of the giant beasties. There will also be some business with Cade's daughter Tessa (Nicola Peltz); her secret racing driver boyfriend Shane (Jack Reynor); Stanley Tucci's Joshua; his geologist assistant Darcy (Sophia Myles); "the CEO of the Chinese Transformers", played by Li Bingbing; and Kelsey Grammer's Harold Attinger, the film's non-robot big bad.
Transformers: Age Of Extinction will be with us on July 10.


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Whether you first heard this as a child in Sunday School or know it from its origin as a traditional Quaker hymn, you will enjoy this lively and fun arrangement from Joseph Martin! With a gospel-style piano
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by Staff Writers
Vienna, Austria (SPX) Jul 22, 2013
Although it may not be immediately obvious, the mechanical properties of optical components have a significant impact on the performance of lasers employed in precision sensing applications.
Currently, the mechanical damping of such components, and the inherent mechanical fluctuations they generate, present a roadblock to further advancement of ever more precise measurements of time and space. For the past decade, researchers in the precision measurement community have been searching for a solution that allows for the development of high-reflectivity mirrors with simultaneously high mechanical quality.
Now an international collaboration of scientists from Vienna, Austria and Boulder, Colorado, USA has demonstrated a novel technology for producing mirrors with a tenfold reduction in mechanical loss. The work, reported in Nature Photonics, represents an entirely new approach for generating high-quality optical coatings, key components of state-of-the art laser systems for precision measurement.
Combining aspects of semiconductor mirrors borrowed from surface-emitting diode lasers, an epitaxial layer transfer technique gleaned from advance nanofabrication processes, and an in-depth knowledge of mechanical losses gained from the field of cavity optomechanics, the researchers in Vienna realized a novel "crystalline coating" technology.
The unprecedented improvement in mechanical quality, verified by the world-renowned experts in precision measurement in Boulder, arises from the intrinsic order of the high-quality semiconductor materials used to fabricate the mirrors.
The development of such materials was historically driven by advances in microelectronics and photonics, enabling the technologies we interact with every day: high-speed integrated circuits, diode lasers for telecommunications, etc.
Previously, the major impediment to utilizing such materials in general optics applications was two-fold: On the one hand, optical surfaces are in many cases curved, which presents a problem for direct crystal growth techniques, and on the other hand,typical optical substrates are made of glass with an amorphous structure that lacks the order required for seeded crystal growth. Circumventing these limitations, the researchers came up with a microfabrication process to separate and then bond high-quality single-crystal films onto curved glass substrates.
The mirror technology described in the manuscript promises to accelerate progress in the development of narrow linewidth laser sources for use in precision measurement systems, spanning time keeping with optical atomic clocks, as well as fundamental physics research involving precision tests of relativity, cavity quantum electrodynamics, and quantum optomechanics.
Moreover, leveraging advanced semiconductor production techniques, there is a clear path to implementing large area crystalline coatings in astronomical endeavors, such as gravitational wave detectors.
According to Professor Ye, "The development of highly phase coherent optical sources is a key technology that impacts a vast range of scientific explorations. In our own lab, we are able to demonstrate the most stable optical atomic clock thanks to these narrow linewidth lasers, and the progress is marching on!"
"The collaboration with Jun's group was fantastic," states Garrett Cole, who, along with Wei Zhang, is the lead author on the work. "They not only had the courage to take on an unproven technology, but also the ability to tackle a tremendously difficult task: quickly achieving thermally limited noise performance with their characterization system and verifying the high mechanical quality of our mirrors." Following this initial demonstration, the scientists are already hard at work to further improve the technology.
Going forward, they plan to combine their novel coatings with the previously demonstrated single-crystal silicon cavity developed by researchers at JILA and PTB in Braunschweig, Germany (see "The World's Most Stable Laser," September 2012:). In combination, an all crystalline cavity (comprising crystalline coatings, substrates, and spacer) would enable world-record stability and hence a new milestone in laser technology.
G. D. Cole, W. Zhang, M. J. Martin, J. Ye, and M. Aspelmeyer, "Tenfold reduction of Brownian noise in optical interferometry," Nature Photonics, vol. 7, no. 8, August 2013.
Related Links
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Crystalline Mirror Solutions
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May 24, 2011
ASC Releases Guide to University Archives' Film and Video Material
The Archives Service Center mounted a new finding aid that provides a detailed inventory of all the film and video material held in the University Archives. This collection (ca. 1928-ca. 2001) of over 2,300 items mainly pertain to Pitt athletics, but also document various University events and history. The moving image material ranges from interviews and speeches by prominent University figures to sports highlight videos and University institutional messages. Types of media include VHS tapes, Betacam SP tapes, ¾ inch U-matic tapes, and 16 millimeter film.


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Nicolette Hahn Niman, a lawyer and cattle rancher, made several fatal linguistic errors in her op-ed, ban on gestation crates, which she, like most animal welfarists (but not abolitionists), think will lead to a significant decrease in animal suffering. Among other things, Niman writes that "we ask the ultimate sacrifice of the animals we eat." However, we don't ask any farm animal anything. We have decided that we will raise and slaughter certain animals for food, and they have no say in the matter. They aren't offering themselves to us, as per the definition of sacrifice. They don't willingly, joyfully give their lives so that we may . . . nosh on their flesh when we don't even need to. Furthermore, implicit in the idea of sacrifice is that it's all worth it in the end, because some higher, grander idea is being honored. What's the higher idea here? The taste buds of Americans?
A legitimate sacrifice would be: Stop eating pigs, even if you think they taste good, because killing without necessity is unjustifiable. Do you see the sacrifice? You give something up to honor a more important notion.
1 Comment
Comment by
kbenstonon #
Excellent post.
Directly pertinent, as well, to the mutilation and destruction of millions of "lab animals," whose deaths are, in the argot of the biomed lab, an act of "sacrifice" (the phrase "sacing the animal" is often used). As with Niman and the happy meat movement, the most galling feature of this unintentionally illuminating linguistic practice is its provision of 'moral' comfort to the butchers.


text:
Submit News
Lenovo Airs First Ultrabook W/ Dedicated GPU, Acer Clones MacBook Air
Jason Mick
September 4, 2011 3:00 PM
Recipient E-mail
Sender E-mail
Hey... this looks kind of familiar (Acer clones the MacBook Air).
(Source: Pocket Lint/Popular Mechanics)
Lenovo has the right idea, picking a dedicated mobile GPU. Unfortunately its pick is about the weakest dedicated GPU you can find, offering minimal gains over Intel's HD 3000.
(Source: Lenovo via Hot Hardware)
Acer hopes to use ultraportable to recover from netbook slump
Faced with an evaporating netbook market, Acer Inc. (
) has
to fourth place in global, fifth place in U.S. sales. In full scale panic mode, the company has vowed to
transform itself to be more like Apple, Inc.
I. Acer Clones the MacBook Air -- Will it "Just Work"?
A critical first step in that transformation was
[press release] on Friday at Germany's
technology show in Berlin. Acer pulled the wraps off its first "ultrabook", a slick ultra-portable mid-size laptop with decent power.
Dubbed the Acer Aspire S3, the ultrabook clearly targets Apple's
popular MacBook Air
, following it closely in looks. It features a slender thin hybrid plastic-metal design, which pairs an outer light metal lid with a plastic body. The lid is 17 mm tall at its thickest point (identical to the MacBook Air) and tapers to 13 mm.
The S3 can be found in a 13.3-inch and 11.6-inch design. They pack a 1376x768 pixel display. The 13.3-inch model weighs "less than 1.4 kg (3 lbs.)", which, according to
, is 1.35 kg (2.976 lb), to be precise. That places it roughly in line with the 2.96 lb. 13.3-inch MacBook Air.
The trackpad could also be mistaken for the MacBook Air's, almost -- it features the same multi-touch capable flat glass design which disguises clickable buttons in the bottom half of the depressed rectangle.
The peripheral ports are almost identical to the MacBook Air's with a 3.5 mm headphone jack, SD card slot, and twin USB 2.0 ports. It trades Apple's proprietary ThunderBolt connector for a more widely used full-sized HDMI port. There's 1.3 MP camera and microphone for Skype chats, just like the Air. And likewise Bluetooth 4.0 connectivity is also supported.
The laptop features a 20 GB SSD, which holds the
Windows installation and media you want to play at faster speeds. The Acer Green Instant On features leverages this to promise 2.5 second boot times from sleep and 6 second boots from deep sleep. The battery promises 7 hours of life (identical) to the MacBook Air.
So what's different between the S3 and the MacBook Air? Well, as we mentioned the case implementation is a bit divergent. And the price is significantly lower -- 799 € (appr. $1,150 USD) for a model equipped with a
1.7 GHz ultra-low voltage (ULV) second-generation Core i5 CPU
from Intel Corp. (
) and 4 GB of RAM.
A comparable MacBook Air is $150 more, at $1,300. However, the Acer comes with a slower 320 GB traditional HDD in its stock configuration, where the Apple comes with a 128 GB SSD. Given the internal small-size SSD for the OS, about the affects of this swap should be limited to slower times for some application launches, large file saves, or large copies -- OS launch time will be spared.
The price on the fully loaded model is moderately attractive given the larger amount of RAM. With a 240 GB SSD, 1.7 GHz ULV Core i7 CPU, and 8 GB of DDR3 RAM, you will have to spend 1199 € ($1,720 USD) -- versus $1700 USD for a comparable MacBook Air with a 256 GB SSD, but only 4 GB RAM.
Like Apple, the biggest disappointment in this portable is the lack of dedicated graphics, which will make GPU-accelerated applications like Photoshop, web browsers, and video games slower.
Acer must beware, its competitors -- Toshiba Corp. (
) and ASUSTEK Computer Inc. (
) both plan to launch
similar ultraportables
at under $1,000 USD.
Also given Apple's
propensity for suing competitors
, it would be unsurprising to see Acer smacked with a lawsuit, given its remarkable similarity to Apple's MacBook Air. Of course we've already stated that we feel
such claims are legally baseless
-- but Apple does have the tendency to make them.
II. Lenovo U300 Packs Graphics Punch
Lenovo Group, Ltd. (
) -- the fastest growing brand internationally -- pulled the wraps off an ultrabook of its own --
the slick U300
Retailing at $1,200 USD in its base configuration, the device is moderately pricey like its Acer and Apple competitors. The design is lightweight and thin, but looks less MacBook Air clone-like than the Acer S3, as it features a shorter taper at the edges.
Overall the specs are similar to the competitors' designs, with one fairly significant difference. The Lenovo U300 packs a Radeon 5470M (1 GB memory) dedicated graphics chip courtesy of Advanced Micro Devices, Inc. (
The bad news here is that the Radeon 5470M isn't really that much more powerful than the stock Intel HD 3000 (found in the Core series chips), barely edging it in some benchmarks. Still, the idea of including a dedicated GPU is a worthy one, so Lenovo's design is important from the standpoint of supporting dedicated mobile GPUs, even if it picks the wrong chip for the job.
Hopefully similar designs will come along soon with beefier chips (e.g. NVIDIA Corp.'s (
) GeForce 540M GT chip).
The Toshiba, Lenovo, Acer, and ASUSTEK products will all ship sometime this fall.
"I want people to see my movies in the best formats possible. For [Paramount] to deny people who have Blu-ray sucks!" -- Movie Director Michael Bay
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