text: Dr Carolyn Greig MSc PhD In 'People' Academic staffDoctoral researchersAdministrative Staff Back to 'School of Sport, Exercise and Rehabilitation Sciences' Senior Lecturer in Nutrition and Ageing Contact details Telephone+44 (0)121 414 firstname.lastname@example.com AddressSchool of Sport, Exercise and Rehabilitation SciencesUniversity of Birmingham Edgbaston Birmingham B15 2TT UK Dr Greig is a translational scientist with research interests in the influence of use, disuse, age and disease on human skeletal muscle mass and function. She is particularly research active in nutritional, physical activity and pharmacological interventions to maintain muscle mass in older healthy men and women and in frail patient groups. Qualifications BSc (Hons) University of Newcastle 1981 MSc University of London King's College 1982 PhD Council for National Academic Awards 1988 (funded by the Sports Council of Great Britain) Biography Dr Greig graduated from Newcastle University (BSc Hons Physiology in 1981) and obtained an MSc in Human and Applied Physiology at King's College London (1982) and a Sports Council funded PhD from the Polytechnic of North London (1988). Following 2 years as a Lecturer in Exercise Physiology at St Mary's College of Higher Education, Strawberry Hill, she joined Prof Archie Young at the Royal Free Hospital School of Medicine as a Lecturer in Human and Applied Physiology in the Department of Geriatric Medicine. She created a Human Performance Laboratory and embarked on a programme of work based on development of methods of measurement and strategies to improve physical performance and functional ability in older people. During this time she trained the field workers who made the functional ability measurements included in the English National Fitness Survey, supervised MSc and PhD students and was the first non-clinical recipient of the Dhole Bursary of the British Geriatrics Society. From 1992-2000 she took a career break and moved to Edinburgh where she worked as a part-time visiting lecturer at Queen Margaret University before resuming her research career at Edinburgh University (2000-2012) as a Research Fellow before taking up her present position within the prestigious MRC-ARUK Centre for Musculoskeletal Ageing Research at the University of Birmingham. Since 2000 Dr Greig has been a grantholder on >£2M of research funding and has authored over 50 peer-reviewed manuscripts, book chapters and review articles. Research Dr Greig's research is focussed on the maintenance of muscle mass and function in older healthy men and women and in frail patient groups (including upper GI cancer, stroke). She is particularly interested in the following areas: responsiveness to physical activity/ nutritional/ pharmacological interventions; molecular, biochemical and functional (imaging) biomarker discovery and evaluation; the influence of glucocorticoids on regulation of muscle mass; measurement of muscle protein synthesis; direct monitoring of physical activity. Current research projects Responsiveness of older muscle to resistance exercise training and protein/ essential amino acid supplementation (MRC-ARUK Centre PhD studentship Danielle Thomas, collaborators Dr Phil Atherton/ Dr Ken Smith, University of Nottingham). Impact of lifestyle modifications on function and health related quality of life in older individuals with sarcopenic obesity (PhD studentship Christos Theodorakopoulos collaborator and principal supervisor Dr Elaine Bannerman, Queen Margaret University, Edinburgh). Molecular and functional biomarkers for skeletal muscle frailty (main collaborators Prof KCH Fearon, Prof JA Ross, Prof A MacLullich University of Edinburgh; Dr I Gallagher University of Stirling; Dr H Wackerhage University of Aberdeen). Direct objective physical activity monitoring as an outcome for studies of healthy ageing/ cancer cachexia (collaborators Dr E Ferriolli University of Sao Paolo; Dr S Chastin Glasgow Caledonian University). Magnetic Resonance Elastography/ 3T MR protocol development (Edinburgh University small project grant and Moray Endowment fund, collaborators Dr Calum Gray, Prof Neil Roberts Dr S Semple, P Kennedy). Comparison of MR and DXA derived estimates of muscle mass (collaborators Dr Peter Tothill and Dr Calum Gray, University of Edinburgh). Using pedometers to promote physical activity in patients after stroke (Stroke Association PhD Fellowship to Sarah Nicholson, collaborator and principal supervisor Prof GE Mead, University of Edinburgh). Clinical trials in sarcopenia: Advisor Phase III trial nutritional supplementation in elderly community dwelling men and women (Danone Nutricia). Other activities Dr Greig is the current lead of the Physiological Society's Human and Exercise themed group and a co-opted member of the Meetings Committee. She is also a member of the Society for Sarcopenia, Cachexia and Wasting Disorders. She reviews for a number of journals and is a member of the Editorial Board of the Journal of Aging and Physical Activity. Publications The Human Urinary Proteome Fingerprint Database UPdb. Husi H, Barr JB, Skipworth RJ, Stephens NA, Greig CA, Wackerhage H, Barron R, Fearon KC, Ross JA. Int J Proteomics. 2013;2013:760208. doi: 10.1155/2013/760208. Epub 2013 Oct 9.PMID: 24222850 Responsiveness of muscle size and strength to physical training in very elderly people: A systematic review. Stewart VH, Saunders DH, Greig CA. Scand J Med Sci Sports. 2013 Oct 24. doi: 10.1111/sms.12123. [Epub ahead of print] PMID: 24151875 Physical fitness training for stroke patients. Saunders DH, Sanderson M, Brazzelli M, Greig CA, Mead GE. Cochrane Database Syst Rev. 2013 Oct 21;10:CD003316. doi:10.1002/14651858.CD003316.pub5. PMID: 24142492 CT and Clinical Predictors of Fatigue at One Month after Stroke. Kutlubaev MA, Shenkin SD, Farrall AJ, Duncan FH, Lewis SJ, Greig CA, Dennis MS, Wardlaw JM, Maclullich AM, Mead GE. Cerebrovasc Dis Extra. 2013 Mar 22;3(1):26-34. doi: 10.1159/000347113. PMID: 24052792 Exercise for depression. Cooney GM, Dwan K, Greig CA, Lawlor DA, Rimer J, Waugh FR, McMurdo M, Mead GE. Cochrane Database Syst Rev. 2013 Sep 12;9:CD004366. doi: 10.1002/14651858.CD004366.pub6. PMID: 24026850 A novel oral tracer procedure for measurement of habitual myofibrillar protein synthesis. MacDonald AJ, Small AC, Greig CA, Husi H, Ross JA, Stephens NA, Fearon KC, Preston T. Rapid Commun Mass Spectrom. 2013 Aug 15;27(15):1769-77. doi: 10.1002/rcm.6622. PMID: 23821570 A systematic review of perceived barriers and motivators to physical activity after stroke.Nicholson S, Sniehotta FF, van Wijck F, Greig CA, Johnston M, McMurdo ME, Dennis M, Mead GE.Int J Stroke. 2012 Sep 13. doi: 10.1111/j.1747-4949.2012.00880.x. [Epub ahead of print]PMID: 22974010 Is tissue cross-talk important in cancer cachexia? Johns N, Greig C, Fearon KC. Crit Rev Oncog. 2012;17(3):263-76. Review. PMID: 22831157 Exercise for depression.Rimer J, Dwan K, Lawlor DA, Greig CA, McMurdo M, Morley W, Mead GE.Cochrane Database Syst Rev. 2012 Jul 11;7:CD004366. doi: 10.1002/14651858.CD004366.pub5. Review. PMID: 22786489 Physical fitness training for patients with stroke: updated review.Brazzelli M, Saunders DH, Greig CA, Mead GE. Stroke. 2012 Apr;43(4):e39-e40. Review. No abstract available. PMID: 22567668 Suppression of skeletal muscle turnover in cancer cachexia: evidence from the transcriptome in sequential human muscle biopsies. Gallagher IJ, Stephens NA, MacDonald AJ, Skipworth RJ, Husi H, Greig CA, Ross JA, Timmons JA, Fearon KC. Clin Cancer Res. 2012 May 15;18(10):2817-27. doi: 10.1158/1078-0432.CCR-11-2133. Epub 2012 Mar 27. PMID: 22452944 The use of pedometers in stroke survivors: are they feasible and how well do they detect steps?Carroll SL, Greig CA, Lewis SJ, McMurdo ME, Sniehotta FF, Johnston M, Johnston DW, Scopes J, Mead GE. Arch Phys Med Rehabil. 2012 Mar;93(3):466-70. doi: 10.1016/j.apmr.2011.08.047. PMID: 22373934 Sexual dimorphism modulates the impact of cancer cachexia on lower limb muscle mass and function. Stephens NA, Gray C, MacDonald AJ, Tan BH, Gallagher IJ, Skipworth RJ, Ross JA, Fearon KC, Greig CA. Clin Nutr. 2012 Aug;31(4):499-505. doi: 10.1016/j.clnu.2011.12.008. Epub 2012 Jan 31.PMID: 22296872 Physical activity monitoring: a responsive and meaningful patient-centered outcome for surgery, chemotherapy, or radiotherapy? Ferriolli E, Skipworth RJ, Hendry P, Scott A, Stensteth J, Dahele M, Wall L, Greig C, Fallon M, Strasser F, Preston T, Fearon KC. J Pain Symptom Manage. 2012 Jun;43(6):1025-35. doi: 10.1016/j.jpainsymman.2011.06.013. Epub 2012 Jan 24. PMID: 22269181 Fatigue after stroke: a systematic review of associations with impaired physical fitness.Duncan F, Kutlubaev MA, Dennis MS, Greig C, Mead GE. Int J Stroke. 2012 Feb;7(2):157-62. doi: 10.1111/j.1747-4949.2011.00741.x. Review. PMID: 22264369 Relationship between sedentary behaviour, physical activity, muscle quality and body composition in healthy older adults. Chastin SF, Ferriolli E, Stephens NA, Fearon KC, Greig C. Age Ageing. 2012 Jan;41(1):111-4. doi: 10.1093/ageing/afr075. Epub 2011 Jul 12. No abstract available. PMID: 21749993 Free Article Detecting and categorizing frailty status in older adults using a self-report screening instrument.Barreto Pde S, Greig C, Ferrandez AM. Arch Gerontol Geriatr. 2012 May-Jun;54(3):e249-54. doi: 10.1016/j.archger.2011.08.003. Epub 2011 Sep 1. PMID: 21889807 Physical fitness training for stroke patients. Brazzelli M, Saunders DH, Greig CA, Mead GE. Cochrane Database Syst Rev. 2011 Nov 9;(11):CD003316. doi: 10.1002/14651858.CD003316.pub4. Review. PMID: 22071806 The advantages and limitations of cross-sectional body composition analysis. MacDonald AJ, Greig CA, Baracos V. Curr Opin Support Palliat Care. 2011 Dec;5(4):342-9. doi: 10.1097/SPC.0b013e32834c49eb. Review. PMID: 21986910 Blunting of adaptive responses to resistance exercise training in women over 75y. Greig CA, Gray C, Rankin D, Young A, Mann V, Noble B, Atherton PJ. Exp Gerontol. 2011 Nov;46(11):884-90. doi: 10.1016/j.exger.2011.07.010. Epub 2011 Jul 28. PMID: 21821111 Intramyocellular lipid droplets increase with progression of cachexia in cancer patients. Stephens NA, Skipworth RJ, Macdonald AJ, Greig CA, Ross JA, Fearon KC. J Cachexia Sarcopenia Muscle. 2011 Jun;2(2):111-117. Epub 2011 May 31. PMID: 21766057 Free PMC Article Proteomic analysis of urinary upper gastrointestinal cancer markers. Husi H, Stephens N, Cronshaw A, MacDonald A, Gallagher I, Greig C, Fearon KC, Ross JA. Proteomics Clin Appl. 2011 Jun;5(5-6):289-99. doi: 10.1002/prca.201000107. Epub 2011 Apr 28. PMID: 21538913 Serum concentrations of myostatin and myostatin-interacting proteins do not differ between young and sarcopenic elderly men. Ratkevicius A, Joyson A, Selmer I, Dhanani T, Grierson C, Tommasi AM, DeVries A, Rauchhaus P, Crowther D, Alesci S, Yaworsky P, Gilbert F, Redpath TW, Brady J, Fearon KC, Reid DM, Greig CA, Wackerhage H. J Gerontol A Biol Sci Med Sci. 2011 Jun;66(6):620-6. doi: 10.1093/gerona/glr025. Epub 2011 Mar 7. PMID: 21382886 Is fatigue after stroke associated with physical deconditioning? A cross-sectional study in ambulatory stroke survivors. Lewis SJ, Barugh AJ, Greig CA, Saunders DH, Fitzsimons C, Dinan-Young S, Young A, Mead GE. Arch Phys Med Rehabil. 2011 Feb;92(2):295-8. doi: 10.1016/j.apmr.2010.10.030. PMID: 21272727 Magnetic resonance imaging with k-means clustering objectively measures whole muscle volume compartments in sarcopenia/cancer cachexia. Gray C, MacGillivray TJ, Eeley C, Stephens NA, Beggs I, Fearon KC, Greig CA. Clin Nutr. 2011 Feb;30(1):106-11. doi: 10.1016/j.clnu.2010.07.012. Epub 2010 Aug 19. PMID: 20727625 Can an NSAID a day keep muscle wasting away? Greig CA, Atherton PJ, Rennie MJ.J Physiol. 2009 Dec 15;587(Pt 24):5799-800. doi: 10.1113/jphysiol.2009.184416. No abstract available. PMID: 20008469 Free PMC Article Physical fitness training for stroke patients. Saunders DH, Greig CA, Mead GE, Young A.Cochrane Database Syst Rev. 2009 Oct 7;(4):CD003316. doi: 10.1002/14651858.CD003316.pub3. Review. Update in: Cochrane Database Syst Rev. 2011;(11):CD003316. PMID: 19821305 Exercise for depression. Mead GE, Morley W, Campbell P, Greig CA, McMurdo M, Lawlor DA.Cochrane Database Syst Rev. 2009 Jul 8;(3):CD004366. doi: 10.1002/14651858.CD004366.pub4. Review. Update in: Cochrane Database Syst Rev. 2012;7:CD004366. PMID: 19588354 3D freehand ultrasound for in vivo determination of human skeletal muscle volume.MacGillivray TJ, Ross E, Simpson HA, Greig CA. Ultrasound Med Biol. 2009 Jun;35(6):928-35. doi: 10.1016/j.ultrasmedbio.2008.11.013. Epub 2009 Jan 30. PMID: 19185972 Exercise for depression. Mead GE, Morley W, Campbell P, Greig CA, McMurdo M, Lawlor DA.Cochrane Database Syst Rev. 2008 Oct 8;(4):CD004366. doi: 10.1002/14651858.CD004366.pub3. Review. Update in: Cochrane Database Syst Rev. 2009;(3):CD004366. PMID: 18843656 Association of activity limitations and lower-limb explosive extensor power in ambulatory people with stroke. Saunders DH, Greig CA, Young A, Mead GE. Arch Phys Med Rehabil. 2008 Apr;89(4):677-83. doi: 10.1016/j.apmr.2007.09.034. PMID: 18373998 Fatigue after stroke: the development and evaluation of a case definition. Lynch J, Mead G, Greig C, Young A, Lewis S, Sharpe M. J Psychosom Res. 2007 Nov;63(5):539-44. PMID: 17980228 Stroke: a randomized trial of exercise or relaxation. Mead GE, Greig CA, Cunningham I, Lewis SJ, Dinan S, Saunders DH, Fitzsimons C, Young A. J Am Geriatr Soc. 2007 Jun;55(6):892-9. PMID: 17537090 Evaluation of fatigue scales in stroke patients. Mead G, Lynch J, Greig C, Young A, Lewis S, Sharpe M.Stroke. 2007 Jul;38(7):2090-5. Epub 2007 May 24. PMID: 17525397 Free Article Oxygen uptake kinetics measured at the onset of comfortable self-paced walking in elderly women after hip fracture. Fitzsimons C, Simpson H, Young A, Greig C. Eur J Appl Physiol. 2007 Jun;100(3):355-62. Epub 2007 Apr 12. PMID: 17429682 Skeletal muscle IGF-I isoform expression in healthy women after isometric exercise. Greig CA, Hameed M, Young A, Goldspink G, Noble B. Growth Horm IGF Res. 2006 Oct-Dec;16(5-6):373-6. Epub 2006 Nov 14. PMID: 17107821 Longitudinal changes in muscle strength and mass after acute stroke. Carin-Levy G, Greig C, Young A, Lewis S, Hannan J, Mead G. Cerebrovasc Dis. 2006;21(3):201-7. Epub 2006 Jan 9. PMID: 16401884 Responses to walking-speed instructions: implications for health promotion for older adults.Fitzsimons CF, Greig CA, Saunders DH, Lewis SH, Shenkin SD, Lavery C, Young A. J Aging Phys Act. 2005 Apr;13(2):172-83. PMID: 15995263 Physical fitness training for stroke patients. Saunders DH, Greig CA, Young A, Mead GE. Stroke. 2004 Sep;35(9):2235. Epub 2004 Jul 15. Review. No abstract available. PMID: 15256681 Free Article Physical fitness training for stroke patients. Saunders DH, Greig CA, Young A, Mead GE. Cochrane Database Syst Rev. 2004;(1):CD003316. Review. Update in: Cochrane Database Syst Rev. 2009;(4):CD003316. PMID: 14974012 The trainability of elderly people. Greig C. Age Ageing. 2002 Jul;31(4):223-4. No abstract available. PMID: 12147556 Free Article Views of stroke patients on physical fitness training. Payne A, Greig C, Young A, Mead G. Age Ageing. 2001 Sep;30(5):429. No abstract available. PMID: 11709388 Free Article Muscle function of women aged 65-89 years meeting two sets of health criteria. Skelton DA, Young A, Greig CA. Aging (Milano). 1997 Feb-Apr;9(1-2):106-11. PMID: 9177593 Effects of resistance training on strength, power, and selected functional abilities of women aged 75 and older. Skelton DA, Young A, Greig CA, Malbut KE. J Am Geriatr Soc. 1995 Oct;43(10):1081-7.PMID: 7560695 Strength, power and related functional ability of healthy people aged 65-89 years. Skelton DA, Greig CA, Davies JM, Young A. Age Ageing. 1994 Sep;23(5):371-7. PMID: 7825481 Exercise studies with elderly volunteers. Greig CA, Young A, Skelton DA, Pippet E, Butler FM, Mahmud SM. Age Ageing. 1994 May;23(3):185-9. PMID: 8085501 The quadriceps strength of healthy elderly people remeasured after eight years. Greig CA, Botella J, Young A. Muscle Nerve. 1993 Jan;16(1):6-10. PMID: 8423833 Treadmill walking in old age may not reproduce the real life situation. Greig C, Butler F, Skelton D, Mahmud S, Young A. J Am Geriatr Soc. 1993 Jan;41(1):15-8. PMID: 8418117 Short-stepping gait in severe heart failure. Davies SW, Greig CA, Jordan SL, Grieve DW, Lipkin DP. Br Heart J. 1992 Nov;68(5):469-72. PMID: 1467030 Free PMC Article Novel exercise protocol suitable for use on a treadmill or a bicycle ergometer. Davies SW, Greig CA.Br Heart J. 1992 May;67(5):422. No abstract available. PMID: 1389728 Free PMC Article A controlled trial of community based coronary rehabilitation. Davies SW, Greig CA. Br Heart J. 1991 Jul;66(1):114-5. No abstract available. PMID: 1854568 Free PMC Article Prevalence and severity of morbidity among Gujarati Asian elders: a controlled comparison.Ebrahim S, Patel N, Coats M, Greig C, Gilley J, Bangham C, Stacey S. Fam Pract. 1991 Mar;8(1):57-62.PMID: 2044874 The effect of oral supplementation with L-carnitine on maximum and submaximum exercise capacity. Greig C, Finch KM, Jones DA, Cooper M, Sargeant AJ, Forte CA. Eur J Appl Physiol Occup Physiol. 1987;56(4):457-60. PMID: 3305002 Within-breath changes of airway calibre in patients with airflow obstruction by continuous measurement of respiratory impedance. Davidson RN, Greig CA, Hussain A, Saunders KB.Br J Dis Chest. 1986 Oct;80(4):335-52. PMID: 3620321 Strength training and power output: transference effects in the human quadriceps muscle.Rutherford OM, Greig CA, Sargeant AJ, Jones DA. J Sports Sci. 1986 Autumn;4(2):101-7.PMID: 3586102


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text:
A Study of Zoledronic Acid, Pravastatin, and Lonafarnib for Patients With Progeria
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- No Study Results Posted
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- How to Read a Study Record
Progerias are rare "premature aging" diseases in which children die of severe atherosclerosis leading to strokes and heart attacks. It is a multisystem disease with objective clinical markers for disease progression. These include abnormalities in growth and body composition, bone mineral density, join function, endocrine function, alopecia, and vascular disease. There is currently no therapy proven effective for any of the progressive and deleterious aspects of this disorder.
Progeria is caused by a gene defect in the gene LMNA, coding for the nuclear protein lamin A. Lamin A is normally expressed by most differentiated cells, and requires posttranslational farnesylation to incorporate into the nuclear membrane. This trial proposes to use three agents (zoledronic acid, pravastatin, and lonafarnib) to inhibit farnesylation of abnormal lamin, the disease causing protein in Progeria. The primary objective of this study is to evaluate the feasibility of administering intravenous zoledronic acid, oral pravastatin and oral lonafarnib, to patients wtih Progeria for a minimum of 4 weeks.
|Drug: Lonafarnib Drug: Zoledronic Acid Drug: Pravastatin
|Phase 2
|Study Type:
|Study Design:
|Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
|Official Title:
|A Phase II Pilot Study of Zoledronic Acid, Pravastatin, and Lonafarnib (SCH66336) for Patients With Hutchinson-Gilford Progeria Syndrome (HGPS) and Progeroid Laminopathies
- The primary objective of this study is to evaluate the feasibility of administering intravenous zoledronic acid, oral pravastatin and oral lonafarnib, to patients with Progeria for a minimum of 4 weeks [ Time Frame: 4 weeks ]
- To describe any acute and chronic toxicities associated with treating progeria patients with the combination of zoledronic acid, pravastatin and lonafarnib [ Time Frame: 4 weeks ]
- To investigate which clinical and laboratory studies are needed to monitor or alter therapy to prevent unacceptable toxicity [ Time Frame: 4 weeks ]
- To assess the pharmacokinetics of lonafarnib in patients with progeria. [ Time Frame: 4 weeks ]
- To assay for the inhibition of HDJ-2 farnesylation in Peripheral Blood Leukocytes (PBL) [ Time Frame: 4 weeks ]
- To obtain baseline clinical and laboratory data so that longer-term measures of efficacy will be achievable if treatment continues beyond the 4-week feasibility study period. [ Time Frame: 4 weeks ]
|Estimated Enrollment:
|Study Start Date:
|March 2009
|Study Completion Date:
|April 2009
|Primary Completion Date:
|April 2009 (Final data collection date for primary outcome measure)
Drug: Lonafarnib
|Ages Eligible for Study:
|Child, Adult, Senior
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Genetic Diagnosis: All patients must have confirmatory mutational analysis showing mutation in the lamin A gene.
- Patients must display clinical signs of progeria as per the clinical trial team.
- Patients must be willing and able to come to Boston for appropriate studies and examinations at initiation of study and at week 4 of study.
- Patient must have adequate organ and marrow function as defined by study parameters
Exclusion Criteria:
- Other than the drugs used in this protocol, other drugs targeted to treat Progeria are excluded. Drugs to treat symptoms of Progeria are permitted.
- Patients must not be taking medications that significantly affect the metabolism of lonafarnib at the time they start lonafarnib.
- Patient must have no uncontrolled infection.
- Subjects who have known or suspected hypersensitivity to any of the excipients included in the formulation should not be treated.
- Patients must not be pregnancy of breast-feeding. Female patients of childbearing potential must have negative serum or urine pregnancy test. Male and female patients of reproductive potential must agree to use a medically accepted form of birth control while on study and up to 10 weeks after treatment. It is permissible for female patients to take oral contraceptives or other hormonal methods while receiving treatment with lonafarnib.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00879034
|United States, Massachusetts
|Children's Hospital Boston
|Boston, Massachusetts, United States, 02115
Additional Information:
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
|Responsible Party:
|Mark Kieran, M.D, Ph.D, Children's Hosptial Boston/ Dana-Farber Cancer Institute
|ClinicalTrials.gov Identifier:
|NCT00879034 History of Changes
|Other Study ID Numbers:
|Study First Received:
|April 8, 2009
|Last Updated:
|April 20, 2010
Additional relevant MeSH terms:
Metabolism, Inborn Errors
Genetic Diseases, Inborn
Metabolic Diseases
Zoledronic acid
Bone Density Conservation Agents
Physiological Effects of Drugs
Anticholesteremic Agents
Hypolipidemic Agents
Molecular Mechanisms of Pharmacological Action
Lipid Regulating Agents
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Enzyme Inhibitors
ClinicalTrials.gov processed this record on July 27, 2017


text:
The Divanyolu is the avenue connecting the Beyazit and Sultanahmet Squares. When he took the throne in 323, Constantine wanted to make Byzantium the new capital of Rome , and this is where he started, on the avenue then known as the Mese. This avenue, along which the emperor soon had walls, monuments, cisterns, palaces, hippodromes and the famous Çemberlitas or 'Hooped Column' (the Constantine monument) erected, took on a special significance with the addition of the Hagia Sophia, the splendid monument built by Justinian.
The avenue, which became the 'Divanyolu' with the Turkish conquest of Istanbul , began to be adorned now with Ottoman monuments. In time the Ottoman and Byzantine structures learned to accommodate each other, holding their own against fires, earthquakes, and rebellions right up
to the present-those still standing glad to be alive though filled with grief for the departed.


text: Unblocked panoramic ocean views and soaring sunsets over exclusive Cayucos. This Old World craftsman home was estimated to have cost over $3.5M to build a few years ago and it shows. From the hand cast bronze serpent that feeds the $50,000 marble tub, to the centuries old doors that adorn the interior, to the extensive mosaics that showcase the fountains and entry, to the birds eye Hot Tub sitting above the rim of the world - there is not another house like this, anywhere, especially where you can watch the dolphins & surfers! Designed and custom built by the counties premier artisans this house stands apart from anything else available. Amenities incl: Elevator, Exterior gas lanterns, Modern Lighting & Audio system, Alarm, and much more. Discover the inherent warmth of Old World charm with a modern flair while enjoying the dramatic and stunning vistas. This is an incredible place and your chance to own it is NOW!


text:
Top country band to rock city
THE Front Porch Country Band, which occupied highest place on the American Country Song Top Ten Billboard last year, will give one concert in the city next month.
The band consists of six seasoned professional musicians with Rick Buck on guitar and drums, Johnny Jolin is lead vocalist and also plays guitar, Joseph Paul is on keyboards and drums, Kim Reichley is another singer who also plays bass, Alison Rupert joins in the singing and plays keyboards and guitar and the band is rounded out with Richard Rupert on acoustic and electric guitars.
The Front Porch Country Band's original American music combines the traditional country music style of country legends Willie Nelson, Johnny Cash and Dolly Parton with a touch of folk influence from The Kingston Trio.
The members' skills shine so brightly that concert listeners have been blown away by their musical abilities and commanding presence, according to the Shanghai Dunhuang Co, the local organizer of the concert.
One week after the September 11 event, The Front Porch Country Band engineered and produced the 9-11 tribute album, "America Standing Tall. The American Trilogy," which went straight into the top-10 and was acclaimed as one of the "historical works" and "the all-time greatest country songs" by critics. The success led the band to sign a series of recording and concert contracts.
The Front Porch Country Band has released many albums including a triple-platinum hit which took them to top place on the American Country Song Top Ten Billboard 2003.
7:30pm, May 9
Shanghai Centre Theatre
1376 Nanjing Xilu
Tel: 6248-6443, 6279-8663
100-380 yuan
(Star News)


text:
CHILDREN as young as six are suffering strokes and many are being weaned on pureed junk food.
Rising numbers of babies and toddlers are being diagnosed as clinically obese and even suffering weightlinked diseases that usually appear later in life.
Hundreds of children under three are being treated for obesity at hospitals across the country.
And more more than 5500 children under the age of 16 were diagnosed or treated for obesity in hospitals in the past five years.
The figures were released by 66 of Britain's 168 acute hospital trusts under the Freedom of Information Act.
At least 40 babies under one have been admitted in the past five years.
And public health experts have warned that since hospitals only see the most extreme cases, the true number of obese babies and young kids will be far higher.
Doctors have seen babies fed chocolate, crisps and fizzy drinks.
In some cases infants have been given pureed chips with milk, or mashed up takeaway food.
Many obese children are suffering from breathing difficulties and showing early signs of obesity-related diabetes, the trusts said.
In two examples, a sixyear-old and an eight-yearold suffered strokes because of their weight.
Paul Sacher, of the British Dietetic Association and chief research officer for MEND, a charity that runs obesity treatment and prevention programmes, said many parents simply did not know what they should be feeding their children.
He was also the child health consultant for Jamie Oliver's Return to Jamie's School Dinners.
He said: "I see children all the time who are being given a lolly, a chocolate bar or packet of crisps.
"I see mums pouring fizzy pop into their baby's bottles and in parts of Wales they put chips in milk in bottles.' Meanwhile, experts have identified the age when you start letting it all go and pile on the pounds - 41.
That's the age when your appetite for fighting the flab starts to wane and the weight goes on.
A survey of the over 40s marking diabetes week has found one in three regret letting their weight pile on when they get past 40.
More than four in ten felt they had let themselves go with over half in the West Midlands admitting they had lapsed.
A third of people over 40 said they wish could turn back the clock on their health.
And 34 per cent said if they could turn back the clock, they wouldn't have allowed themselves to become overweight.
Getting a middle-aged spread leads people to put themselves at higher risk of developing Type 2 diabetes caused by being overweight or obese.


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John Hurt Could Be Terry Gilliam's New Don Quixote
With more casting to come
Earlier this year, Terry Gilliam revealed to us that he'd finally rounded up some fresh financing for long-cherished, once-begun, dream/nightmare project The Man Who Killed Don Quixote. He talked about a potential September start date and how he'd had to make some changes to reflect a reduced budget. But it appears he's still aiming high in casting terms, reaching out to John Hurt as a possible new star.
Talking at a Q&A during the Derby Film Festival this weekend, Hurt revealed that Gilliam has at least asked him about the idea. He didn't elaborate on whether he was in negotiations for the role, but it's certainly a promising start – Hurt would surely be a great fit for Gilliam's universe, and knows his way around the weirder corners of cinema.
Variety has also offered an update on the film's new progress, but in a dispiriting light, it appears that Terry has once again postponed the start of shooting to sometime in 2015. The trade mag's story has the director and producer Adrian Guerra kicking off casting on the film, so we can expect more announcements (including Hurt, if he definitely signs) in the coming weeks and months.
There's also a chance that the pair will be hitting film festival markets to secure the remaining cash they need to get Quixote moving. We can but hope – if only for Terry's continued mental health…


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FRANKFURT, Germany (AP) — The United States has drawn North Korea, Colombia and Sweden in group play for next summer's Women's World Cup.
The top-ranked Americans were the last team to qualify for the 16-nation tournament, beating Italy in a home-and-home playoff on Saturday after being stunned by Mexico in the semifinals of regional qualifying. Still, the U.S. is a top seed, as are two-time defending champion Germany, Japan and Brazil. The tournament will be played June 26 to July 17 at nine sites in Germany.
The U.S. opens June 28 against North Korea, the fourth straight time these nations will meet in the group stage. The Americans beat the North Koreans 3-0 in 1999 and 2003, but tied 2-2 in 2007. The U.S. will face World Cup newcomer Colombia on July 2 and finish group play four days later against Sweden, U.S. coach Pia Sundhage's old team.
The Americans won the World Cup twice in 1991 and 1999, and they have finished no worse than third.
Germany begins the tournament June 26 in Berlin against Canada, the champion of North and Central America and the Caribbean. It also plays African champion Nigeria and France in what could be the toughest of the four groups. Japan will face New Zealand, Mexico and England, while 2007 runner-up Brazil drew Australia, former champion Norway and Equatorial Guinea.
The Americans cannot play Germany until at least the semifinals. The Germans beat the U.S. 3-0 in the 2003 semis but the Americans are 5-0-2 against the world's No. 2 team since then, including a 3-2 victory in the Algarve Cup final this year.
Guidelines: You share in the USA TODAY community, so please keep your comments smart and civil. Don't attack other readers personally, and keep your language decent. Use the "Report Abuse" button to make a difference. Read more.


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If you have been charged with a crime, you need the support of an experienced attorney willing to stand up and fight for your rights. Frank Sandoval, Attorney at Law has been helping clients like you get through difficult times. Clients continue to praise the firm for their work on their cases, many of which have ended in a reduced or dismissed sentence.
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- Texas
- United States Federal Courts for the Western District of Texas
- Northeastern University School of Law, J.D., 1992
- Pepperdine University, B.A., Political Science, 1988
Professional Memberships and Achievements:
- Phi Zeta Chi
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ENERGY AND WATER DEVELOPMENT APPROPRIATIONS ACT, 2005 -- (House of Representatives - June 25, 2004)
The SPEAKER pro tempore. Pursuant to House Resolution 694 and rule XVIII, the Chair declares the House in the Committee of the Whole House on the State of the Union for the consideration of the bill, H.R. 4614.
The Chair designates the gentleman from Georgia (Mr. Isakson) as Chairman of the Committee of the Whole, and requests the gentleman from Michigan (Mr. Upton) to assume the chair temporarily.
Mr. HULSHOF. Mr. Chairman, I move to strike the last word.
(Mr. HULSHOF asked and was given permission to revise and extend his remarks.)
Mr. HULSHOF. Mr. Chairman, I want to, first of all, say thank you to my friend for his kind words and the work that he has done on the upper Mississippi; and, two, the chairman of the subcommittee during general debate, the chairman talked about trying to find a balanced approach, and I applaud that; and I think the underlying bill does just that.
We certainly appreciate trying to fund the critical programs through the upper Mississippi River basin. Despite, quite frankly, the recent core budgets that have made this task extremely challenging, it is critical that adequate funding be provided to support a multiple-use river, as the gentleman from Wisconsin spoke of.
Whether it is the Environmental Management Plan that he spoke of to the navigation study and a comprehensive plan for flood control and floodplain management, the Mississippi River does, in fact, have diverse uses and, accordingly, diverse needs.
Again, I applaud the chairman and the subcommittee who have worked with our office and our constituents to make a difference in the basin. In fact, I know that the chairman has logged thousands of miles personally to inspect and view many of the civil works projects around the country, and I would be remiss if I did not extend a personal invitation to the gentleman to come to Missouri and to see the upper Mississippi and especially the locks and dams as the previous chairman did some years ago.
In fact, it was on that visit that we had a chance to view from the air some of the true benefits of the Environmental Management Plan specifically, and it really gave me a sense of a greater appreciation for what the Corps of Engineers was doing with the EMP. Already hundreds of acres of prime wetlands have been reclaimed, critical back waters have been restored, habitats are thriving. We are helping to promote flood control throughout the region, and we know too often, I think, the Corps of Engineers receives only barbs for its environmental record; but I think its successes in the EMP, which has really only been limited by funding issues, are indeed worthy of praise.
So accordingly, I support the bipartisan efforts of the gentleman from Wisconsin (Mr. Kind), my friend, as well as the gentleman from Ohio (Mr. Hobson), to achieve this balanced approach to the management of one of our Nation's greatest natural resources, the mighty Mississippi.


text: Publishing RAD Zone1CIPM® ProgramGain the skills to drive smarter, more effective investment decisions and maximize investors' value Register for the September 2017 Exam Registration is open until 31 July 2017 for Principles and Expert level exams. If you passed Level III of the CFA® Program, you can proceed directly to Expert Level. Register now Not ready to register? Sign up to receive more information and be notified of key registration dates: Principles | Expert Already registered? Log in to access your candidate resources Enroll in the Certificate in Investment Performance Measurement (CIPM) Program for advanced, globally relevant, and practice-based investment performance and risk evaluation skills. The CIPM designation will set you apart as a deeply knowledgeable investment performance professional committed to your clients' best interests and your firm's success. Learn more about the CIPM Program or download the CIPM fact card (PDF). Principles Level Exemption CFA charterholders and others who have passed Level III are now eligible to proceed directly to the Expert Level of the CIPM Program. Learn more about the exemption (PDF). View the recording and download the presentation (PDF) from our 6 October 2016 webinar for those who are eligible for this exemption. What Can the CIPM Program Do for You? Completing the CIPM Program will help you: Deliver more actionable investment insights Improve manager search and selection Produce comprehensive and transparent reports Increase risk awareness Provide feedback to maximize your firm's efficiency What Does the CIPM Program Cover? The CIPM curriculum is based on an advanced body of knowledge that is continuously reviewed and updated by more than 1,000 active investment practitioners around the world to ensure it reflects the relevant trends and core competencies needed by today's top investment employers. Learn more about the curriculum Next Steps How to become a CIPM certificant Explore the CIPM Program course of study Learn more about the CIPM exams Register for the next CIPM exam Publishing RAD Zone2


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Welcome to the Utah Public Notice Website: Your central source for all public notice information in Utah
South Weber:
City Council
Entity: South Weber
Body: City Council
Subject: Fire Protection Business
Notice Title: City Council Meeting
Notice Type: Meeting
Event Start Date & Time: October 8, 2013 05:30 PM
Event End Date & Time: October 8, 2013 07:00 PM
PUBLIC NOTICE is hereby given that the City Council of SOUTH WEBER, Davis County, Utah will meet in a regular public meeting TUESDAY, 8 OCTOBER 2013 at the City Council Chambers, 1600 E South Weber Dr, South Weber, UT commencing at 6:00 p.m. ____________________________________________________________________________________________________ PUBLIC WORK MEETING: 5:30 p.m. REVIEW AGENDA ITEMS AND WARRANT REGISTER COUNCIL MEETING: 6:00 p.m. PLEDGE OF ALLEGIANCE – Councilmember Poll PRAYER - Councilmember Thomas APPROVAL OF AGENDA DECLARATION OF CONFLICT OF INTEREST CONSENT AGENDA (These items are considered by the City Council to be routine and will be approved by a single motion. There will be no separate discussion on Consent Agenda items prior to the vote, unless removed from the Consent Agenda to be considered separately.) • Approval of 10 September 2013 City Council Meeting Minutes • Approval of 17 September 2013 City Council Work Meeting Minutes • Approval of 24 September 2013 City Council Meeting Minutes 6:05 p.m. QUARTERLY REPORT: Fire Department – Tom Graydon, Fire Chief 6:10 p.m. YOUTH CITY COUNCIL OATH OF OFFICE: Administered by Erika Ahlstrom, City Recorder 6:15 p.m. COUNTRY FAIR DAYS 2013 REPORT: Michael and Amy Poff, Chairs 6:25 p.m. PUBLIC COMMENT Keep public comments to 3 minutes or less per person MAYOR CITY COUNCIL ASSIGNMENT UPDATES & COMMENTS CITY MANAGER STAFF CLOSED EXECUTIVE SESSION: CLOSED EXECUTIVE SESSION – UTAH CODE 52-4-204 & 52-4-205: THE COUNCIL WILL CONSIDER A MOTION TO ENTER INTO CLOSED SESSION FOR THE PURPOSE OF DISCUSSION OF CHARACTER, PROFESSIONAL COMPETENCE, OR PHYSICAL OR MENTAL HEALTH OF INDIVIDUAL(S)
Notice of Special Accommodations:
In compliance with the Americans with Disabilities Act, individuals needing special accommodations during this public hearing should notify the City Recorder at 801-479-3177.
Notice of Electronic or telephone participation:
Other Information
This notice was posted on: October 03, 2013 11:01 AM
This notice was last edited on: October 03, 2013 11:01 AM
Board/Committee Contacts


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The Sulphur Springs powerlifting team takes eight competitors today to regional action in Lindale. The top two finishers in each weight class advance to the state meet later this month in Abilene.
"I told them, I've already made the reservations in Abilene. So I am putting the pressure on them," Flowers said with a smile. "I just hope I need to take the bus for all of them and don't have to rent a mini-van."
Lifters from Sulphur Springs rank near the top in their region and they expect success at meet.
Competitors include: Taylor Link, 132-pound class; J.R. Rivera, 148-pound class; Eddie Arciga, 148-pound class; Johnny McSheffery, 165-pound class; Joe Scott, 181-pound class; Jake Russell, 198-pound class; Tadarious Johnson and Andrew Burton, super heavyweights.
"We have Link at No. 2 in the region. Arciga is No. 3, Rivera, Scott and McSheffery are No. 6 in their divisions. Russell is No. 1 and has been all year; Burton and Johnson are Nos. 3 and 4 in this region," Flowers said.
"We have a pretty good chance that five or six of those guys could make it out," the coach said. "The best chances probably are Taylor and Russell. The others it depends on how much they lift and how much the other people in the meet lift."
Flowers said the East Texas region is pretty tough and features gritty competitors from Corsicana, Mount Pleasant, Lindale and other teams.
"The super heavyweight guys, Burton and Johnson, are going to have to really get it on to make it," Flowers said.
Flowers said that this team does not have the numbers of some teams, but is stronger overall.
"Last year we had 22 kids and I could pick any of those 22 and they would lift well," Flowers said. "This team is smaller, but they are stronger. This is the strongest group I have had in my three years of coaching powerlifting."
The team has seen lifters ranked near the top all year. The squad has missed the top notch all year with four first place finishes, that was with getting a late start due to the 16-game football season and winning state.
"We did not get to start until later than usual, because of football," Flowers said. "But that gave us a hunger for winning. The football team won state, then the basketball team got in the playoffs. We started powerlifting and we won first place in all of our meets. These kids just want to keep on winning, it's contagious. I told them to be humble and set your goal at going to state and go get it."
Flowers said, "To get to state you have to go PR (personal record) in all three events. I've never had anybody go to state. But I feel good about this group, like I said earlier. I've reserved the rooms."
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Latest question:
How do you think the new GigE standards will influence the machine vision industry?
Respond or ask your question now!
2006 FEB 14 - (NewsRx.com) -- Isis Innovation Ltd., the commercial development arm of the University of Oxford, U.K., announced that engineering science researchers at Oxford have developed an imaging technique that visualizes pulmonary nodules with fewer false positives than other methods.
Lung cancers continue to kill more people than any other type of cancer, with current survival rated at only 12%-15%. Early detection and treatment greatly improves prognosis. For example, detecting and treating tumors less than 3 cm in size increases survival to 75%.
Lung cancer can be detected at a sufficiently early stage using spiral computed tomography (CT). A single thoracic CT scan may comprise some 500 separate "slice" images. The improved resolution of modern CT scanners enables earlier detection of abnormalities, but the interpretation times become impractical and errors increase.
This problem could theoretically be solved by using computer-aided detection (CAD) to help radiologists manage the demand for more numerous and improved image analysis. However, the computer-based systems that have been proposed to date have demonstrated low sensitivity and a large number of false-positive results, says Isis Innovation.
The University of Oxford engineering science researchers have developed a new method incorporating a process called Visual Moving Features (VMF) for detecting pulmonary nodules. VMF detects a predefined structure in a subject by image analysis based on a representation of the structure constructed across a number of parallel image planes.


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David Henley
|David Henley
|February 5, 1749
Charlestown, Massachusetts
|January 1, 1823
Washington, D.C.
|United States Army
|Years of service
|1776–1779, 1793–1823
|American Revolutionary War
David Henley (February 5/12, 1748/9 – January 1, 1823) was a Continental Army officer during the American Revolutionary War, who served as George Washington's intelligence officer and Prisoner of war commandant. He later served as the Agent for the United States Department of War for the Southwest Territory (later Tennessee) in the 1790s.
Henley was born in Charlestown, Massachusetts, the eldest child of Samuel and Elizabeth Cheever Henley.[1] On January 8, 1776, he set fire to Charlestown which was occupied by the British. In that same year, he served a major under General William Heath, and briefly as an adjutant general under General Joseph Spencer.[1] On January 1, 1777, he was made Colonel of the Massachusetts Regiment. He was in command at Cambridge, Massachusetts, when the troops that had been captured at Saratoga were brought thither. Henley stabbed an insolent but unarmed British prisoner. Court-martial proceedings were held at Cambridge from January 20, 1778, to February 25, 1778, but he was acquitted. British General Burgoyne challenged him to a duel, which was to take place in Bermuda. He accepted the challenge but the duel never happened.
General Washington selected him in November 1778 to be his spymaster, and charged him with compiling information to give him a snapshot of British capabilities. He largely succeeded in that task. Henley retired from the Army the following year.[1]
In 1793, Colonel Henley was appointed by President Washington to represent the Agent of the Department of War for the Southwest Territory, in Knoxville, Tennessee. In this capacity, he was Superintendent of Indian Affairs, as well as quartermaster and paymaster for locally-stationed troops and militia.[1] He was known to be a hothead, but was also a strong law-and-order man. Tennessee's Constitutional Convention was held in his office at the corner of what is now Gay Street and Church Avenue in Downtown Knoxville in 1796.[1] He died in Washington, D.C., in 1823, while a clerk in the War Department.[1]
In 1994, the Knoxville Federal Courthouse was proposed the site of his office. However it was later constructed at the northwest corner of Main Street and Gay Street. Both Henley Street and the Henley Street Bridge (or Henley Bridge) in Downtown Knoxville are named after him.[1] A tablet was placed by the state of Tennessee at the location of his office in 1947.
Henley-Putnam University, a highly specialized university devoted to intelligence, security, and counterterrorism founded in 2001, is named for Henley and Israel Putnam.[2]
See also[edit]
- Intelligence in the American Revolutionary War
- Intelligence operations in the American Revolutionary War
- Rose, Alexander. Washington's Spies. The story of America's first spy ring. Bantam, 2006.
- Henley, David. The proceedings of a general court-martial held at Cambridge, on Tuesday the twentieth of January, and continued by several adjournments to Wednesday the 25th of February, 1778, upon the trial of Colonel David Henley. Published in 1778. Printed by J. Gill (Boston).
- Neely, Jack. Knoxville's Secret History. Scruffy City Publishing (Knoxville), 1995.
- Tennessee State Library and Archives: David Henley Papers


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HBO Grants Bill Maher's 'Real Time' Two More Seasons
Let the conservative outrage ring. Bill Maher still has a job.
HBO announced Tuesday morning that the outspoken, controversial comic and commentator's discussion show "Real Time with Bill Maher" has been given two more seasons worth of the premium cable network's blessings, Deadline reported this morning.
The eleventh and twelfth seasons of Maher's series will carry him through not only November presidential election, but also the next midterm Congressional election. Despite 27 nominations and episodes averaging 4.1 million gross viewers, "Real Time" has never won a Prime Time Emmy.
"Bill Maher's irreverent wit and fearless insights make him the perfect observer for these unpredictable times," said HBO programming president Michael Lombardo.
It's been an interesting time to be Maher. He's no stranger to reaping what his words sow - ABC canned Maher's "Politically Incorrect" late-night roundtable after post-Sept. 11, 2001 attacks calling the U.S. Armed Forces "cowards" - but managed to earn frowns from conservative and liberal loyalists following radio host Rush Limbaugh calling a Georgetown University law student a "slut" and "prostitute" on Limbaugh's radio show following her testimony supporting insurance coverage for contraceptives.
Conservatives belly-ached that Maher remained gainfully employed as a broadcast personality, claiming he'd said far, far worse things while others cried for Limbaugh to be dropped from the airwaves. Meanwhile, some liberals weren't thrilled when Maher expressed his sympathies for the right-leaning pundit's plight.
Hate to defend #RushLimbaugh but he apologized, liberals looking bad not accepting. Also hate intimidation by sponsor pullout— Bill Maher (@billmaher) March 7, 2012
Real Time with Bill Maher


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Established in 1996, Southern Bar Services is a family run business which has been providing mobile bar services in the South for many years.
Whether you're organising a festival or planning an event, we provide mobile bars for all occasions. From small family gatherings to larger public events, whether your event is outdoors or in a village hall.
Located in an area not listed above? Please contact us as we may be able to help.
To complete your booking simply click here and print off the booking form and complete required details and post with your booking fee . Alternatively, email your booking form to email@example.com. We do not accept credit cards but can take payments by BACS or cheque.
For a wide range of drinks at pub prices, call 01256 632 950


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A GROUP of volunteers who help transform the lives of breast cancer sufferers undergoing treatment have won an award.
South West Fishing for Life was set up five years ago to act as therapy and respite for people suffering or recovering from breast cancer.
The 30 volunteers and coaches help people learn how to fish.
In June, the group found out they had been given The Queen's Award for voluntary services across the South West which is equivalent to an MBE.
They will receive their award on Tuesday (November 26) at a ceremony at Wimbleball Lake presented to them by the Lord Lieutenant of Somerset, Lady Gass.
Gillian Payne, 67, came up with the idea to set up the club after reading a book about a lady suffering from breast cancer and hearing how fishing techniques proved beneficial to build up tissues and muscles for people undergoing treatment.
She said: "I really am so excited about the group receiving the award next week.
"We found out in June that we had won and it's felt like a really long time since then.
"We wouldn't exist without all of the volunteers and coaches who give up their time freely to help and I wish there was an individual award for each of them."
They were nominated by Jan Ross, from Engage West Somerset, a charity who help voluntary organisations with applying for funding and helping and running their organisations.
Jan said: "I've been involved with Gillian's idea pretty much from the beginning and it is wonderful to see how much they've grown.
"It can be quite challenging for some people setting these sort of things up to know where to look for funding and that's where I came in and helped with the applications and all sorts.
"My husband Keith and I have always been invited to the fishing days and annual events and it's great to see the support offered to the people who go along.
"I feel they were merited official recognition for all their hard work and it has taken a long time since I filled the forms in but the award is the icing on the cake."
The group sessions have become very popular and attract 30 members, mostly women at Wimbleball Lake who fish for two hours and then have a sit down lunch.
There are six branches, five in the South-West and one in the Pennines.
Gillian added: "I would love for this to happen all around the country, it will take a lot of work but I'm determined.
"It's about more than just fishing, everyone supports each other and gets to be around others who understand exactly what they are going through, we're like a family.
"It gets them out for a few hours and some like to talk about their experience, others don't what matters is that everyone has a good time."


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Spotlight Recipes: A Meaty Christmas Menuby Dana Angelo White in Healthy Holidays, Healthy Recipes, December 21, 2009
When it comes to Christmas dinner, anything goes. Every family has their favorite classics, but we like to mix it up each year with simple, yet elegant dishes. This holiday, we're doing a lighter, steakhouse-inspired meal but without all those extra calories.
Toast the Holiday
I love to greet my guests with a cocktail. It's the best time of year for pomegranates, so these martinis are perfect. Make a large pitcher ahead of time instead of running back and forth from the bar.
RECIPE: Pomegranate Cosmos
Light Bite
Clams make a tasty and delicate first course. Dress them up for the holiday with red bell pepper, pancetta and a touch of Parmesan cheese.
RECIPE: Clams Casino
Main Event
Beef tenderloin is a lean cut of meat that's always a crowd-pleaser. To go along with it, serve baked potatoes with a side of creamy herb and yogurt topping and some simple wilted greens.
- Roasted Beef Tenderloin with Roasted Red Pepper and Black Olive Sauce
- Baked Potatoes with Creamy Herb Topping
- Sautéed Spinach
Sweets & Treats
I don't crank out the desserts because guests inevitably bring some along — cookies, sweet breads and more. To balance, serve a fruit salad or some decadent chocolate-covered strawberries finish off the meal.


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Garbage Truck Toys - An ideal Holiday Gift
Garbage Truck Toys - An ideal Holiday Gift
Still looking to determine what to find the picky kid within your family? Provide him with something special vacant gonna soon forget. Among the best gifts you'll be able to share with a little daughter boy is often a garbage truck toy. These toys make the perfect gift because boys love big, loud vehicles, which is a car they see regularly from an earlier age. Younger kids want to see the garbage truck stay in front with their house and roar your. super heroes
Most children are intrigued by the trash truck. They don't really see the greatest big vehicles rolling down their street on a regular basis. Once a week, this brightly colored vehicle invades the neighborhood, stopping before every house to grab garbage. After that it eats the trash which has a roar, and progresses to another location house in your area. This really is repeated around your entire street. Parent often wonder why kids such as the garbage truck so much. You need to see it from your kid's perspective. What's not to love?
Garbage truck toys really are a favorite gift each year, however, this year's set to become great one. There's a bunch of new garbage trucks out there, with none other than Stinky the rubbish Truck leading the pack. In case you have a boy with your family, you probably may have learned who Stinky is. He's a truck that turns into a garbage munching robot using the press of the lever. He is set being one of several top toys this winter holiday, so don't wait in order to provide him as a gift. Prices have increased about $10 where we were holding earlier in the season.
Together with Stinky, there are a variety of Toy Story 3 toys new for this christmas season. You can buy Lego or regular trucks which make noises once you push a control button. If you have older kids, the Lego trucks are the approach to take. I'd stick to the regular ones for younger kids. The Lego toys generally have smaller parts which are easy to swallow.
For those looking to purchase a toy similar to the ones we enjoyed whenever we were kids, there are some good options. Bruder trucks are made to last, by leaving more for the imagination as opposed to trucks mentioned previously. These are designed to look and work just as the genuine thing. A young child who receives a Bruder truck will seem like he's got his personal garbage truck to drive from the sandbox.
One other good choices Tonka. The Tonka Titan has become a truck that is all-around 3 feet long, and is also an enjoyable toy. New Tonka garbage trucks available on the market feature button you'll be able to press to make realistic sounds. There are also a few trucks with buttons you can press to automatically dump the rubbish cans at the back of your truck. super heroes


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Remember the good old days, 5 or 6 years ago, when people stood in line for hours to buy new tract houses at ever-inflating prices?
Our housing "boom" of recent years was certainly an impressive experience and, unfortunately, so was the subsequent "bust."
In some ways, though, it paled compared to the buying frenzy that went on in the Inland Valley during five turbulent weeks 125 years ago.
Consider Riverside dentist C.W. Sylvester, who bought eight lots at an April 7, 1887, auction in the new community of Claremont. Afterward, he bumped into a late-arriving man desperate to get a piece of the new city.
Sylvester sold the man six of his new lots on the spot, getting much more than he had paid for all eight. He left with two lots and much of his investment still in his pocket.
Such was the craziness going on in the spring 1887 when the Santa Fe Railroad arrived in the Inland Valley. With every mile of track being laid, a new foothill "town" blossomed out of thin air promoted by developers offering dreams of a land bursting with wealth from the area's agricultural bounty.
"Not less than 15 new towns have been created and each one is backed by sufficient capital to make it a success," the Pomona Progress proudly boasted on May 12, 1887.
"The Pomona valley is capable of supporting a very dense population, and why should it not? Who cares to live amid cyclones and cold, when here is a heaven-favored spot?"
As it turned out, some of those boomtowns - places like Marquette, Gladstone, Alosta, Rochester and Magnolia - died as quickly as they appeared for a variety of reasons.
Others - Claremont, La Verne (then known as Lordsburg), San Dimas and Glendora - survived, with roots in those wild days of 1887.
In April and May, three spectacular land auctions were put on by developers of Magnolia (early-day Upland), La Verne and Claremont, attracting buyers through giant newspaper ads filled with glowing descriptions of each community.
And it worked. The value of lots sold in those three auctions was in the vicinity of half a million dollars - and that's 1887 dollars.
Trains brought in the eager buyers from all over Southern California. There were plenty of speculators who like Sylvester bought lots with a small down payment and tried to sell them elsewhere at a higher price, pocketing a nice profit.
On April 7, Claremont developer W.H. Holabird sold 205 lots for from $250 to $750. The value of the land was at least $85,000, plus another $163,000 from land sold outside the townsite, said the Progress.
On May 3, the Bedford brothers held an auction for the new community of Magnolia in today's Upland, featuring what was required at all land auctions of the time - a free lunch. It was a "sumptuous repast, kindly prepared by the good ladies of the Presbyterian Church of Ontario," reported the Ontario Record.
Well-fed, the 500 attendees bought 158 lots in 2 1/2 hours, mostly at $1,000 or less, and Magnolia's future appeared secure.
Three weeks later, developer Isaac Lord of Cucamonga, for whom Lordsburg was named, held a huge sale for his namesake.
Lord had panicked when he learned of a shortage of trains available for charter due to a wreck in Arizona on the Santa Fe line, wrote the Progress on May 19, 1887. He frantically tried to arrange for locomotives to come west from as far as Illinois for the three trains he chartered.
His preparations paid off as 2,500 people poured into the future Lordsburg on May 25, buying lots worth an estimated $200,000.
After the sales, those three cities' success seemed assured, but things quickly turned sour. Speculators - who also played a role in our own most recent "boom" - helped doom many of the boomtowns.
An economic slump followed, and speculators, unable to sell their land, defaulted on their purchases. What seemed like a prosperous start of these fledgling cities turned into disaster.
Magnolia disappeared within a year from a combination of too much speculation and the slump. A Santa Ana wind badly damaged its partially completed hotel, a keystone of the development.
That community didn't recover for almost two decades until Upland won cityhood in 1906.
Hotels, like Magnolia's, were key to making these new cities thrive because they housed visiting Easterners who would hopefully invest in land.
The hotels in Lordsburg and Claremont both failed during the slump, but they did play a key role in the Inland Valley's tradition of colleges and universities.
In Claremont, the failed Hotel Claremont and nearly 300 lots in the new town were sold to the trustees of the new Pomona College, which moved from its original site in Pomona.
In La Verne, the trainside hotel built by Lord also was not a success. It was purchased by members of the German Baptist Brethren, which operated a college in McPherson, Kan.
The purchase, for $15,000, enabled the Brethren to open the doors of today's University of La Verne in September 1891.
Joe Blackstock writes on Inland Valley history. He can be reached at 909-483-9382, email at firstname.lastname@example.com or Twitter @JoeBlackstock


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The Crazy Newshound has found a new Ravens article.
Terrell Suggs planning on rehabbing arm injury
Baltimore Sun (blog)
Suggs tore the biceps late in the Ravens' Dec. 2 home loss to the Pittsburgh Steelers. He sat out the following week's game against the Washington Redskins and was also rested in the team's regular-season finale against the Cincinnati Bengals, a game ...
Link to the full story.


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Healthcare organizations have some of the toughest problems of any industry when it comes to securing their computing environments. They must meet strong regulations, secure massive amounts of data, deal with many types of internal users and devices, and approach the task with an understanding the risks are much higher than normal enterprises. Protection of patient data breaches and financial fraud are important, but more critical aspects must also be considered. Life safety systems must not be impacted from denial-of-service attacks and integrity compromises. A simple altering of medication manufacture or patient dosage assignments could have catastrophic consequences. Additionally, healthcare companies face strong regulatory oversight and scrutiny when it comes to patient privacy as well as drug handling and distribution.
One aspect which is no different than other organizations is the fact they have much to secure and not enough resources to cover everything. They must prioritize and make intelligent decisions. One way to get a grasp on the most important threats is to understand the attackers. If you know who is attacking you and why, resources can be efficiently mustered to the defense.
Applying the Threat Agent Risk Assessment (TARA) methodology can help. With that in mind, Intel has released a whitepaper discussing improvements to healthcare risk assessments in order to maximize security budgets.
To my collogues in the healthcare industry, who are on the frontlines defending their electronic ecosystems from attack, I hope you find value in the paper.
Improving Healthcare Risk Assessments to Maximize Security Budgets.pdf


text: Tweet The University of Kentucky Alumni Association offers programs that honor students and alumni. Services are offered in order to insure all members and visitors to the Alumni Association a quality, continuing relationship with the university. The programs and services include: Hall of Distinguished Alumni Awards Alumni Distinguished Service Awards Joe Burch Young Alumni Awards Alumni Club Awards Great Teacher Awards Association and Alumni Club Scholarships Legacy Tuition Program Alumni Travel Alumni Career Services


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What causes tomato blossom end rot? How do you treat it?
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Blossom end rot can be caused when calcium and/or water levels in the root zone are low. In our soils, generally calcium is plentiful and low water levels are the cause of the deficiency in the fruit. When water in the soil is in short supply, the plant takes up insufficient amounts of calcium to meet the plants demand. Since calcium is transported in the xylem with the water, during conditions when water is in short supply, most of the water is transported to the leaf and very small amounts are transported to the flowers. This causes a localized deficiency which is expressed as the development of a brown leathery patch on the blossom end of the fruit. This just happens to be the area where fruit growth is most rapid. What conditions cause blossom end rot. There are several. These include low soil moisture levels (water stress), high temperatures (high water demand by the plant), high salinity levels in soils (less available water for plant use), low humidity levels (greater transpiration by leaf so less water and calcium goes to the fruits) and rapid plant growth rates (high demand for calcium) to meet cell wall requirements. Cultivar differences also exist. Small fruited tomatoes are less prone to the disorder than large fruited types. This is due to the rate of cell growth and demand for calcium in the fruits.
How can it be controlled? First try to maintain more even soil moisture levels. Don't let the soil fluctuate greatly from wet to dry and then wet again. Second, maintain more even growth rates. Excess nitrogen in the soil accelerates growth and makes the plants more susceptible to blossom end rot. If salts are a problem, see what can be done to leach them out before growing tomato or water with a less salty water source so the salt levels of the soil does not build up. Finally, after you have done all of these other things, try growing a smaller fruited cultivar, thin the number of fruits on a cluster to 2-3 and spray the plant periodically with calcium nitrate or calcium chloride (4 grams per liter of water) starting about a month after planting. Do every two weeks through the main flowering period.
Nancy Mesner
Program Leader, Water quality Specialist
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- I want to revamp my lawn area plant more drought tolerant plants. Is there a way I can adjust my sprinklers to work with my new landscape - without digging the system up or hiring a professional?


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How You Can Help
The Naomi Berrie Diabetes Center research program has been very successful in getting grants from the National Institutes of Health (NIH). And our clinical care program keeps growing as the amount and sources of our funds grow. However, funds from both the NIH and the insurers aren't even close to enough to allow us to keep expanding our activities to match our vision. It takes constant support from all our friends to do that.
We'll keep applying for and receiving support from the NIH as well as foundations, industry, and the insurers of patients in our care, as well as our Medical School and our Hospital; but support from you can make an all-important difference to our success.
You know what we've already done. You believe in what we will do for you and people in the same boat as you. We hope you'll help us.
Give to help wherever we need help the most
The best way for you to give is in the form of an unrestricted gift. These are used to support both our clinical and research programs. 50% of the funds go to support the clinical care of uninsured children and adults with diabetes. 50% are dedicated to the basic and translational research programs we all hope and believe will ultimately find the cure for diabetes.
Give to help a special cause:
- Support for young faculty
- Recruiting and keeping our faculty
- Endowments for professorships, clinical and research programs
- Our children's diabetes programs including child life, camp programs, and care for underinsured and uninsured patients
- Our diabetes stem cell research program
- Our adult diabetes care programs
- Community outreach and professional education programs
- Research and clinical equipment fund
- Translational diabetes research fund
- Basic science relating to the causes and treatments of diabetes
- Basic science of body weight regulation
Donate online. Or send a check. Gifts should be made payable to the Naomi Berrie Diabetes Center and mailed to:
Naomi Berrie Diabetes Center
Attn: Development Office
Columbia University Medical Center
1150 St. Nicholas Ave.
New York, NY 10032
For more information please call Jamie Gutter at 917-484-0090 or send an email to firstname.lastname@example.com.
We thank you so much for your support.
Volunteer at the Berrie Center
Other ways you can help.
The Berrie Center Advisory Board is a committed group of professionals, business and community leaders who share a common passion for the Berrie Center's mission to advance innovative diabetes research programs and patient care initiatives through advocacy, fundraising, and leadership. Click here to learn more about this volunteer group.
We can also sometimes use the help of volunteers in preparation for large events, such as research symposia or research screenings, and for help with mailings. To learn about this volunteer opportunity, please contact Jennie Preval at email@example.com.


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At any moment in the game, you can give up adventuring and go back to a safer life. You just need to camp and choose the retire from game option.
As soon as you "throw in the towel", so to speak, the game will calculate your 'Score' based on your performance in Calradia. Tales about your retirement life and your portrait will be shown with your score. You can choose to 'Remain in retirement' or cancel it and get back to business.
Score calculation factors Edit
|Your towns
|100 points per town
|Your castles
|50 points per castle
|Your villages
|20 points per village
|Friendly towns (relation >= 40)
|20 points per town
|Friendly villages (relation >= 40)
|4 points per village
|Enemy towns (relation <= -40)
|-40 points per town
|Enemy villages (relation <= -40)
|-8 points per village
|1 point per 200 denars
| Inventory value
Household, Town, and Castle
storages not included
|1 point per 200 denars
|1 point per renown
|Friends (relation >= 40)
|10 points per friend
|Enemies (relation <= -40)
|-10 points per enemy
|Days spent
|-1 point per day
|2 points per victory
|-3 points per defeat
|Quests completed
|4 points per quest
|1 point per 5000 experience
|Heroes found
|2 points per hero
|Heroes left the party
|-4 points per hero
| Difficulty
Final bonus/penalty factor
|finalscore = score * difficulty / 75 * difficulty / 75
Using 'Force save' option will not give any bonus.
Your retirement life Edit
Your life post-adventuring will be shown as soon as you choose the retire option. This can be read BEFORE actually choosing between real retirement or rejoining the game, so you don't have to risk losing your saved data.
Life as a commoner : Score ?-1849 Edit
|Only too late do you realise that your money won't last. It doesn't take you long to fritter away what little you bothered to save, and you fare poorly in several desperate attempts to start adventuring again. You end up a beggar in (town), living on alms and the charity of the church.
|Only too late do you realise that your money won't last. It doesn't take you long to fritter away what little you bothered to save. Once every denar has evaporated in your hands you are forced to start a life of crime in the backstreets of (town), using your skills to eke out a living robbing coppers from women and poor townsmen.
|Only too late do you realise that your money won't last. It doesn't take you long to fritter away what little you bothered to save, and you end up a penniless drifter, going from tavern to tavern blagging drinks from indulgent patrons by regaling them with war stories that no one ever believes.
|Free farmer
|The silver you've saved doesn't last long, but you manage to put together enough to buy some land near the village of (village). There you become a free farmer, and you soon begin to attract potential wives/husbands. In time the villagers come to treat you as their local hero. You always receive a place of honour at feasts, and your exploits are told and retold in the pubs and taverns so that the children may keep a memory of you for ever and ever.
|Tavern keeper
|The silver you've saved doesn't last long, but it's enough to buy a small tavern in (town). Although the locals are wary of you at first, they soon accept you into their midst. In time your growing tavern becomes a popular feasthall and meeting place. People come for miles to eat or stay there due to your sheer renown and the epic stories you tell of your adventuring days.
|You've saved wisely throughout your career, and now your silver and your intelligence allow you to make some excellent investments to cement your future. After buying several shops and warehouses in (town), your shrewdness turns you into one of the most prominent merchants in town, and you soon become a wealthy man/woman known as much for your trading empire as your exploits in battle.
Life as a noble : Score 1850-? Edit
|Minor noble
|As a landed noble, however minor, your future is all but assured. You settle in your holdfast at (village), administrating the village and fields, adjudicating the local courts and fulfilling your obligations to your liege lord. Occasionally your liege calls you to muster and command in his campaigns, but these stints are brief, and you never truly return to the adventuring of your younger days. You have already made your fortune. With your own hall and holdings, you've few wants that your personal wealth and the income of your lands cannot afford you.
|Powerful noble
|There is no question that you've done very well for yourself. Your extensive holdings and adventuring wealth are enough to guarantee you a rich and easy life for the rest of your days. Retiring to your noble seat in (castle), you exchange adventure for politics, and you soon establish yourself as a considerable power in your liege lord's kingdom. With intrigue to busy yourself with, your own forests to hunt, a hall to feast in and a hundred fine war stories to tell, you have little trouble making the best of the years that follow.
|Major noble
|As a reward for your competent and loyal service, your liege lord decrees that you be given a hereditary title, joining the major nobility of the realm. Soon you complete your investitute as baron of (village), and you become one of your liege's close advisors and adjutants. Your renown garners you much subtle pull and influence as well as overt political power. Now you spend your days playing the games of power, administering your great fiefs, and recounting the old times of adventure and glory.
|Liege's right hand
|Though you started from humble beginnings, your liege lord holds you in high esteem, and a ripple of shock passes through the realm when he names you to the hereditary title of count/countess of (town). Vast fiefs and fortunes are now yours to rule. You quickly become your liege's most trusted advisor, almost his equal and charged with much of the running of his realm, and you sit a throne in your own splendourous palace as one of the most powerful figures in Calradia.


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Bob Gotti
Cornerstone Of Salvation - Poem by Bob Gotti
For believers Christ is our Cornerstone, as our salvation is in Him alone,
He's our Cornerstone and Foundation; in Him alone we obtain salvation,
Everything required for you and me, was completed by God at Calvary,
Anything added has only diminished, Christ's last words, "It is finished."
Is it Christ or religion which lies, which of these two should we despise?
Requirements added by sinful man, or the Lord's Eternal Salvation plan;
It was The Father, who sent Jesus, to save souls from unrighteousness,
For The Father, this came at a price, as His Son was to be His Sacrifice.
Christ sacrificed Himself, for us to be, redeemed and join God's Family,
Even though Christ had bore the cross, it was sinful men, who were lost,
For it was Christ, The Spotless Lamb, Who bore all the sin of fallen man,
Finishing what God alone had started; this is God's Truth to be imparted.
While God starting at predestination, God chose to bring to all Salvation,
Those He predestined He foreknew, those being sinners like me and you,
It was Christ, for all sinners, Who died, that, in Christ, we can be justified,
Called and chosen by Jesus Christ, that through Him we gain Eternal Life.
Jesus, the Beginning and the End, brings to man, God's Salvation friend,
It was the Lord, Who chose Grace, to redeem all who come through faith,
His saving Grace, through Christ alone, saving all who God calls His own,
Those sinners, who Christ has justified, for all Eternity, God has glorified.
(Copyright ©03/2013)
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Bob Gotti's Other Poems
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Still I Rise
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If You Forget Me
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Caged Bird
Maya Angelou
Rudyard Kipling
Stopping By Woods On A Snowy Evening
Robert Frost
A Dream Within A Dream
Edgar Allan Poe


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'96' Rated. No.1 Cigar of 2011. Yeah, it's that good. Sporting a unique 2006 Corojo wrapper, Prensado was completely built around its limited, Honduran-grown wrapper leaf and earned a whopping 96 points by Cigar Aficionado in addition to No. 1 Cigar of the Year Honors for 2011.
Alec Bradley cigars have been redefining what enthusiasts expect out of premium, Honduran blends. Alan Rubin definitely knows what we as consumers want from a great cigar. His blends are perfectly balanced, with medium to full bodies and offer smooth, unique complexities that keep your attention from start to finish. We feel Alan Rubin has easily, truly earned every high rating he's received, such as the '94' rated Tempus and even this '96' rated Prensado.
Prensado comes box-pressed, and features a fantastic blend of Nicaraguan and Honduran premium long leaf tobaccos. The blend burns slow, even, and exudes flavorful nuances of chocolate mixed with toasty notes of leather and earth. The first inch will leave an intense, spicy character on your palate before slightly mellowing out by delivering some sweet notes that are to die for. Enjoy this full-bodied blend in the afternoon or after your favorite meal.
Smooth, rich full flavor. Surprisingly smooth for a bold cigar.
This is the best cigar I've smoked this year. It burned perfectly til the last 1/3 and was mellow, but plenty flavorful all at the same time, leather and cocoa and nothing off or bitter. Definitely worth a go, I picked up a few more to age out in the box, but it was really good upon arrival.
I am just a very early beginner at cigars and am starting with premium lines, usually in samplers packs, but when I came across this one - The Prensado Grand Toro, it was killer.
It burns very well, draws great, and the last half leaves the best buzz I have encountered. This is a full bodied and tasty smoke, not for the weak-at-heart.
I think it is my new favorite.


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remote kernel via ssh
Hi, someone has asked this question before, but it was never resolved, and
now that the dept server has disallowed rsh, I'm running into the same
problem. I have the official ssh2 for windows, so the port forwarding
commands are all there. What do I need to do to run a remote kernel over


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Fire department continues its tradition of hanging decorations downtown
For most of us, Christmas is a time of celebration, and in this last column for 2013, I want to celebrate the Newberg Fire Departments tradition of decorating our city with lights, scrolls and wreaths each holiday season.
Rather than talk about what happens today, which has been covered often by this newspaper, Id like to go back to the beginning and give my version of how the tradition started.
The date was Tuesday, Christmas Eve, 1929. Because the paper youre now holding is dated Tuesday, Christmas Eve, 2013, were 84 years to the day removed from when it all began.
Prior to 1929, the concept of a Christmas symbol belonging to everyone was not a part of the Grubby End culture.
Celebrations involving more than the individual family were typically church affairs. Denominations marked the holly jolly season with religious services, choir and orchestra concerts, special yuletide lectures, door-to-door caroling, eats, treats and everything in between.
In the meantime, the practice of decorating a large tree, then putting it in the middle of a downtown street to arouse the Christmas spirit throughout an entire community, had become trendy in other Oregon locations.
Not to be outdone, during the late fall of 1929, the local fire boys decided Newberg should do the same, but deferred taking action on the activity. Their hope was that some other local organization would like the idea and pick up where the fire department had left off.
It wasnt that the guys were lazy, its just that, in addition to fighting fires and providing other rescue type services for the city, the firemen were busy sponsoring a three-act play titled, Headstrong Joan. Recruiting the players, holding rehearsals and selling tickets left little time for anything extra.
Now if this sounds a little bit out of character for a fire department, remember, the decade of the 1920s was the golden age of community theater in small-town America, with everyone (pardon the pun) getting in on the act. Often, the productions were fund-raisers; they were always goodwill raisers.
The latter was certainly true of the Newberg Fire Department, as it was always looking for ways to present a good image of itself to townsfolk who, more often than not, considered recruits, in the words of a Graphic reporter about this time, a rough and ready bunch, too often criticized rather than praised.
At some point, this whole Christmas tree idea became a textbook example of the old axiom, If its everybodys responsibility, its nobodys responsibility. As Christmas week approached, not one group had stepped forward to help out.
To remedy the situation, the fire department quickly assembled a committee, secured a big tree in the local woods and named it the Community Tree. It was hauled to downtown on Christmas Eve and put in the middle of the street at the intersection of Howard and First streets, right in front of City Hall.
With financial assistance from the Chamber of Commerce, 1,000 bags stuffed with a candy, nuts and oranges were assembled for the kids.
When the tree lights finally came on, blinking and twinkling their Christmas magic to the crowd, the Claude Cummings Orchestra played Holy Night and the party was on.
After greetings by Pacific College (now George Fox University) President Levi Pennington, the Junior Leaguers of the Methodist Episcopal Church contributed more carols.
And then finally the big man with the red suit made his entrance. The kids squealed with delight.
Friends and relatives of George Candeaux, the man behind the white beard, gave a knowing smile.
The firemen shook hands and patted each another on the back.
And all was right with the world.
The Graphic reported later: The firemen are giving notice they will hold a community Christmas tree and program again next year and with an early start they anticipate an even more successful event.
Merry Christmas everyone and a special holiday greeting to retired Newberg Fire Chief Al Blodgett, who has done so very much for more than 50 years to help keep this decorating tradition alive.


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Racer X is reporting that Motocross rider James Stewart is about to sign a deal with Joe Gibbs Racing.
While detail are still scarce at this time, sources say that Team Suzuki was also pursuing Stewart, and an announcement will be coming some time early next week.
Stewart, who is 24-years-old and a Florida native, is currently riding for San Manuel Yamaha.
From Racer X:
Racer X has learned that the much-rumored James Stewart to Joe Gibbs Racing deal is imminent. While this has been discussed for over a month, we also know that Team Suzuki was making a push for Stewart and that nothing official would come until next week (we reported this in our Monster Energy Cup Notebook story yesterday).
Sources now indicate that a JGR/Stewart announcement is indeed coming early next week. Details are scarce. Will he be on a Yamaha? Outdoors too? Is there a potential NASCAR component? What about a teammate and sponsors?
We'll know more next week, but for now, our sources say James Stewart will be riding for Joe Gibbs Racing in 2012.


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"We enjoyed toooo much .. very interesting palace with too much secret itineraries and information ..Mustafa A., Saudi Arabia – See more reviews
What To Expect
The Doge's palace features the very best and the very worst of Venice's history - from vast paintings by Tintoretto and Veronese to the wooden slot where accusations of treason were slipped to the fearsome Secret Police. To wander the corridors of the Duke's palace is to understand the Republic of Venice, for better or for worse.
Our tour of the palace combines a guided visit to the Secret Itineraries with a free visit to Doge's Chambers, assuring you get the most complete tour of the Doge's Palace. Marvel over ceilings frescoed by Tintoretto to show Justice presenting herself to the Doge while you think of all the feet that have shuffled on the tiles you stand on - ambassadors waited nervously in this very spot for an audience with the Doge in the Hall of Four Doors. Then there's the numerous flattering works produced on demand by the masters of the time - 'Virtues of the Republic' in the Council Room was Veronese's rosy outlook on the state of his nation while 'The Triumph of Venice' in the Senate Hall was where Tintoretto paid his dues on a high ceiling.
For all of the splendor that its corridors hold, you would never guess what is hidden in the attic upstairs in the Doge's palace. Follow your guide to the attic prison where Venice's famous lover and writer Casanova was kept for months before he miraculously managed a successful escape. Peering around this dark room, considering the security that must have existed, it's almost impossible to imagine how he did it - never mind, our guides have the answers.
Casanova was not the only man to see the Doge's palace on less than favorable terms. After your guide has left you, you'll have the opportunity to walk through spectacular Bridge of Sighs - so named for the prisoners that walked its length on their way to cells across the canal. As they took their last look at beautiful Venice they couldn't help but sigh.
Your guide will leave you inside the Doge's palace so that you can cross over to the 16th century New Prisons. If time allows wander around inside to see the graffiti that lines cells here, protestations of innocence etched out on the walls.
A visit to the Doge's Palace is a rollercoaster experience, taking you from the artistic highs of Renaissance Venice to its grim bottom. When you step, blinking back into the sun, your head will be full of masterfully executed paintings and needlessly executed prisoners. One thing is for sure - you'll never again see Venice in the same light.
Chamber of the Secret Chancellery
Torture Chamber
Casanova's Cell
Chamber of the Inquisitors
Chamber of the Great Council
The Chamber of the Scrutinio
The Compass Room
The Chamber of the Council of Ten
Senate Chamber
The Council Chamber
Antechamber to the Hall of the Full Council
The Four Doors Room
Skip the Line Access and Entrance Ticket to the Doge's Palace
Entrance into the Doge's Palace Secret Itinerary
Meals and drinks
Personal expenses
Tips and gratuities
Optional activity costs
Children below 6 years old are not permitted on this tour.
It is the individual responsibility of all visitors to arrive at the tour departure points.
This tour involves a fair amount of walking, comfortable shoes are recommended. We are unable to accommodate customers with baby carriages, strollers, wheelchairs or walking disabilities.
This tour is operated with a maximum of 25 guests.
Booking modifications made within 72 hours of tour date will be charged an amendment fee.
This tour is operated in English only.
The tour ends inside the Doge's Palace.
All our card payments are protected by thawte to give you peace of mind.
Up to
10% off
8 hours
Free Cancellation
E-voucher accepted
4 hours
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1 hour
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1 hour and 30 minutes
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30 minutes
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2 hours
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2 men appeal for shorter sentences in 2001 Armstrong County slaying
Two men serving life sentences for killing a drug dealer more than a decade ago filed court documents on Monday seeking shorter prison terms because they were 17 years old when they were arrested.
Bryan Chambers, 29, and James A. Provitt, 30, were convicted of first-degree murder and other offenses for the June 14, 2001, shooting and beating death of 48-year-old Larry Dunmire of Kiskiminetas Township, Armstrong County.
Dunmire was shot 14 times and struck with a blunt object as many as 30 times. His body was found facedown along Moore Road in Bell Township near his burned van, police said.
Chambers and Provitt were sentenced to a mandatory term of life imprisonment without the possibility of parole.
Recent appellate court decisions have determined that mandatory life sentences issued to juveniles are unconstitutional. Chambers and Provitt last year filed appeals based on a U.S. Supreme Court ruling.
On Monday, amended appeals were filed in Westmoreland County to assert that they are entitled to shorter sentences under the U.S. Constitution's due process and equal rights provisions.
Both men want to be sentenced to lesser charges for which they were convicted. In addition to first-degree murder, a jury found Chambers and Provitt guilty of third-degree murder, which carries a maximum sentence of 40 years in prison.
District Attorney John Peck said the appeal is without merit and noted that, even with new sentencing hearings, both still could be sentenced to life imprisonment under present state law.
"This is a claim that no court has recognized," Peck said on Monday.
Peck previously conceded that a Greensburg teenager convicted of first-degree murder and serving life in prison will need to be resentenced.
Angela Marinucci, now 21, was 17 when she was arrested for the February 2010 torture slaying of Jennifer Daugherty, 30, of Mt. Pleasant, a mentally challenged woman who was held captive in a Greensburg apartment by six roommates before she was fatally stabbed.
The U.S. Supreme Court ruled that hearings must be held for juveniles in such cases instead of mandatory sentences being automatically imposed.
A resentencing hearing for Marinucci is expected to be scheduled when an appeal of her conviction is resolved.
Rich Cholodofsky is a staff writer for Trib Total Media. He can be reached at 724-830-6293 firstname.lastname@example.com.


text: Annnette June Montemurro (b. 1930) of Coquitlam transcribed some of her father Edward Coppard's tape recorded stories after he died on December 26, 1993 and she researched the Coppard clan's English family history to self-publish Any Danger of Getting A Cup of Tea (Stoney Creek Publishing, 2003). Edward Coppard, who immigrated to Canada in 1955, was a marathon runner and gifted raconteur who served in the Royal Air Force.


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Intimate venue for shows and a great place to see your friends. I saw Jackson Brown there in November standing room only, though I had great seats if not a little too close to the double doors, but near the stage.
The bar is open and life is good. Great place to attend any event!