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When it was opened, out of one nodule came man and from the other woman.
The size of the fish evidently regulated that of the nodule.
I laid open a nodule with a blow of the hammer, and my heart leaped up when I saw that it enclosed an organism.
Fig. 9 is from Northern Ohio, and is carved from a nodule of iron ore.
The first of these cartilages articulates with a nodule situated a little above the middle of the first bone of the sternum.
The gland, which is seen as a nodule, is drawn forward with forceps.
The essential symptoms of glanders are the nodule, the chancre, the glands, and the discharge.
Nature's method of repair was a hypertrophy of the subintimal connective tissue and the formation of a nodule at that point.
In the cells of the nodule the bacteria multiply and develop, drawing material from their host.
Doubtless, an eddy from this hole accounts for the deposit of snow and, by accretions, for the erection of the nodule.
early 15c., from Latin nodulus "small knot," diminutive of nodus "knot" (see net (n.)). Related: Nodulated; nodulous; nodulation.
nodule nod·ule (nŏj'ōōl)
A small node.
A small mass of tissue or aggregation of cells.


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RENO, Nev. (AP) - B.J. Daniels passed for 363 yards and three touchdowns, including a 56-yard scoring toss to Andre Davis with 38 seconds left in the game Saturday, to help South Florida come from behind to beat Nevada 32-31.
Daniels also threw a 51-yard TD to Davis, who finished with 12 catches for 191 yards, and a 52-yard score to Chris Dunkley with 2:37 remaining. Lindsey Lamar added 85 yards rushing on just 8 carries for the Bulls (2-0), who trailed 21-6 in the opening quarter.
Cody Fajardo passed for 271 yards and a touchdown and ran for 134 yards and two more scores, and Stefphon Jeffersonran for 135 yards for the Wolf Pack (1-1), who won their opener last week at Cal and had lost only once in their last 18 home games.
Nevada, which moved this season from the Western Athletic Conference to the Mountain West, dominated early and led 21-13 at the half but Lamar ran 35 yards for a touchdown on South Florida's opening drive of the second half to cut the lead to 21-20.
Fajardo answered with passes of 23 yards to Brandon Wimberly and 19 yards to Kendall Brockbefore faking a hand off and rolling around the right side 14 yards for a touchdown on the final play of the third quarter to make it 28-20.
Allen Hardison's35-yard field goal put Nevada ahead 31-20 with 8:16 left in the game before the Bulls of the Big East Conference mounted their comeback.
Daniels, who also ran for 53 yards on 11 carries, completed 22 of 40 passes on the game but was 10 of 17 for 227 yards in the fourth quarter alone. Demitri Murray added 60 yards rushing for the Bulls.
Fajardo, a sophomore, completed 27 of 38 passes on the game. He was practically flawless early, leading Nevada to touchdowns on its first three possessions, rushing for 88 yards in the first quarter and completing 9 of his first 10 pass attempts, including a 29-yard scoring toss to Joe Huber that put the Wolf Pack on top 21-6.
After a roughing the quarterback penalty against defensive end Brock Hekking, Demetri Murray got loose for an 18-yard run to set up his own 1-yard touchdown dive and Maikon Bonani converted the extra point this time to cut it to 21-13 9:20 before the half.
Nevada was driving again before Sam Barrington forced Jefferson to fumble and JaQuez Jenkins recovered on the USF 14. After Markus Smithwas called for interfering with Sterling Griffin near midfield, Daniels completed a 57-yard pass to Terrence Mitchell at Nevada's 13, but the officials ruled Mitchell had stepped out of bounds before that and the Bulls had to punt again.
Griffin, who was USF's leading returning receiver from a year ago, later apparently injured his right knee and left the game at the half without a reception.
The Bulls also lost defensive lineman Elkino Watson late in the second quarter and defensive back Kayvon Webster in the third quarter to apparent knee injuries.
Fajardo would have had three rushing touchdowns but fumbled in the end zone at the end of a 26-yard run on Nevada's opening drive and tight end Zach Sudfeld recovered for his first career TD and a 7-0 lead less than 5 minutes into the game.
With the loss to USF on Saturday, Nevada fell to 511-442-33 and Hall of Fame Coach Chris Ault saw his record to 227-104-1.
FAJARDO SHINES IN LOSS: Sophomore quarterback Cody Fajardo again was brilliant on Saturday, completing 27-of-38 for 271 yards and a touchdown. He also ran 18 times for 34 yards, including touchdown runs of 1 yard and 14 yards. In all, Fajardo finished with 405 yards of total offense and accounted for three scores. Fajardo hit nine different receivers during the game and did not throw an interception for the second straight game to open 2012.
Fajardo's 100-yard rushing performance was the third of his career at Nevada and his 134 yards marked the second-highest tally of his career. He nearly added a third rushing score but on a long run in the first quarter, the ball was knocked out of his hands at the 2-yard line. Zach Sudfeld pounced on it for the touchdown, however. The last time Fajardo had a multi-touchdown game rushing was Oct. 29, 2011 at New Mexico State when he scored four rushing TDs
JEFFERSON TOPS 100 AGAIN: For the second game of the year, junior running back Stefphon Jefferson topped the 100-yard mark in rushing. He finished with 135 yards on 30 carries against USF and is now averaging 141 yards per game so far in 2012. This marked the fourth time in Jefferson's career that he topped the 100-yard mark.
RUSHING STREAK STAYS ALIVE: With Cody Fajardo and Stefphon Jefferson each eclipsing the 100-yard mark in rushing against USF, Nevada saw it's streak of consecutive games with at least one 100-yard rusher extend to 11 straight games. The streak started on Oct. 8, 2011 when Jefferson went for 100 against UNLV and Nevada has had four different players top the century mark during the course of the streak.
28 STRAIGHT AND COUNTING: Senior receiver Brandon Wimberly caught five passes for 55 yards on Saturday and extended his streak of consecutive games with at least one reception to 28 straight, which was the sixth-longest in the nation entering Saturday.
SUDFELD SCORES: Senior tight end Zach Sudfeld has been through a lot in his six seasons at Nevada and entering Saturday's game at USF, the one thing he had never done was score a touchdown. That changed against USF, although not how one might expect. Sudfeld jumped on top of a Cody Fajardo fumble after a long run in the end zone to get the first collegiate touchdown of his career. In the game, Sudfeld caught five passes for 67 yards to lead Nevada.
HUBER'S FIRST CATCH: Junior wide receiver Joseph Huber entered Saturday's game without a reception during his career at Nevada. That changed in the first half when Huber hauled in a 29-yard pass from Cody Fajardo and raced into the end zone for not only his first catch, but his first touchdown. He finished the game with two catches for 31 yards.
SMITH STARTS: Junior college transfer Markus Smith made the first start of his career at Nevada as the cornerback started in place of the injured Charles Garrett. Smith was third on the team with seven tackles in the game and nabbed Nevada's only turnover of the game when he recovered a USF muffed punt.
EXTRA POINTS: USF won the toss and deferred to the second half … Nevada received the opening kickoff and defended the north goal to start the game … Nevada opened in a two-tight end set with Kolby Arendse getting the start … Chris Barker started his 42nd straight game, all 42 games of his career … Nevada is now 0-1 all-time against schools from the Big East … The Wolf Pack will travel to Tampa, Fla., in 2015 to complete the two-game series between the schools … Punter Chase Tenpenny booted a career-long 58-yarder in the first half … Nevada has 10 fumbles on the year with four lost … The attendance for the game was 22,804.

subset: commoncrawl


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Graduate Course
> Academics > Course
Description Overview >
Course Descriptions
MRKT 6312 (3-3-0) Consumer and Buyer Behavior
This course applies concepts, principles and theories from the various social sciences to the study of factors that influence the acquisition, consumption and disposition of products, services and ideas. The principles and theories from a number of disciplines are used to describe and explain consumer and buyer behavior including economics, psychology, social psychology, sociology, and anthropology. Periodically, Online.
Prerequisite: MRKT 6301.
2004 Dallas Baptist University
See Legal Notice


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jessica bennett Women's Nelson Boot
JNELSO-KSBPG-5 Color: Black / Port / Light Grey, Size: 5 Available in Multiple Colors! Nelson Slouch Boots by Jessica Bennett Features: -Nelson Slouch Boots in Black / Port / Light Grey. -Part of the Nelson collection. -Available in your choice of:. -Black / Port / Light Grey (JNELSO-KSBPG). -Coffee / Blue / Taupe (JNELSO-KSCBT). -Russet / Oatmeal / Taupe (JNELSO-KSROT). -Black Vintage Eagle (JNELSO-VEBLK). -Brown Vintage Eagle (JNELSO-VEBRO). -Cognac Vintage Eagle (JNELSO-VECOG). -Turquoise / Brown (JNELSO-VETRQ). Need help finding or measuring the right size for you? Need to convert your size between country standards? Click here to see our Size Guide!jessica bennett's Nelson boot is a chic interpretation of Western style. Layers of mixed leather with intricate edges and detailed stitching are balanced on a stacked leather heel with elevated height. The mid-calf shaft offers a slim cut, making this boot the perfect choice for pulling over skinny jeans or leggings.
List Price: $ 239.95
Price: $ 239.95


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Unprovoked attack leaves man with serious injuries, police say
Posted Feb. 22, 2012, at 7:44 p.m.
KENNEBUNK, Maine — Police are looking for a man accused in an unprovoked attack that has left the victim with serious injuries.
Police say the man struck another man in the face outside Federal Jack's Restaurant and Pub shortly before midnight Saturday.
WMUR-TV reported on Wednesday that the victim was in intensive care with serious injuries.
Police have surveillance video of the alleged attacker. He's described as about 25 years old, 5 feet, 11 inches tall, 160 to 180 pounds, with dark hair and a scruffy beard. Authorities say he may be from the Dover or Rochester, N.H., area.


text:
I have a net45xx system with m0n0 installed on it. I haven't started to
use the system in production yet, but have it connected to my network. The
web interface is fairly strait forward, but I have a dumb question.
If you use a static IP for your WAN interface, their only seems to be one
IP address. Can you bind multiple IP's to the system (i.e. if you had 5
IP's in your office)? It is necessary to bind those IP's to the WAN
interface, correct? How do you do this?
Joel R. Dare
Hurdman Communications, Inc.
joeld at hurdmanivr dot com
Phone: 801-292-7673 x103
Fax: 801-292-1621


text:
Another Good Thomson Experience: Thomson Majesty Cruise Review by lazlostormaker
Overall Member Rating
Another Good Thomson Experience
Destination: Europe - Eastern Mediterranean
Embarkation: Corfu
We had deck 3 outside superior room, beds had not been arranged as a double, however our friends room had and seeing how this affected space in the room we decided to keep ours separate...blissful nights sleep :)
Standard of cleanliness and room service was very good, lovely two ladies Jessica and Irene looked after us, always had a chat and a laugh with them.
The ship is easier to find your way around than the celebration, but I think I preferred the celebration more, especially after its refurb, I missed the excellent coffee and cake lounge.
Restaurants were very good, although the Seven Sea's one was prone to a lot of vibration when at sea.
For the first time on a cruise we decided to pay for a session in the extra restaurant (Le Bistro on Majesty), £20 a head, oh wow it was absolutely worth it and will do More this every time I cruise from now on.
There are plenty of bars on the ship - TIP if you are on the promenade and don't want to wait for the deck servers, just walk through the SPA on same deck to Flame 52 BAR only discovered this on last two days, always empty and get served very quickly.
Entertainment - caught a couple of shows and the comedian Buster who was also a good singer.
Good standard as usual, however the show lounge is very low especially compared to the Celebration/Spirit, and was a little claustrophobic and of course restricted some of the dance moves.
The Itinery we did was Adriatic Explorer and was very good, Venice, Dubrovnik and Kotor (Montenegro) were the highlights - in Kotor we woke up to find the ship docked in this tiny port surrounded by mountains and you think how the hell did we get here!! (benefit of smaller Thomson vessels?)
Overall a great cruise, good ship, great food, brilliant staff (although the Philippian's were always very cheerful the eastern European bar servers tended not to be) .
Would be happy to sale on the Majesty again, but the Celebration definitely pips it. Less
Published 08/13/14
Cabin review: Outside Superior323
Nice Cabin, kettle added to make us Platinum during the week! ooh
Read Cruise Critic's Thomson Majesty Review >>
Overall Good
Okay ship but definitely not t...
Lovely luxury!
Honest review
First Time Cruisers Loved It
Not good
Honest review
Disappointing second cruise
Cruise Virgin
Sponsored Links


text:
|Food Labeling; Gluten-Free Labeling of Foods; Public Meeting
|FDA Comment Number :
|Submitter :
|Ms. Judith Heinke
|Date & Time:
|09/20/2005 05:09:16
|Organization :
|Ms. Judith Heinke
|Category :
|Food Association
|Issue Areas/Comments
| 1. I would like to see gluten-free on any food products that do not contain "any form" of gluten. Some patients are more sensitive than others and still the ones that aren't are being affected by a small degree of gluten.
2. How Do I identify foods....I do most all of my own cooking and use only natural or fresh foods. Too much time is wasted in trying to identify foods, plus the products in them.
3. There are very few products marked "Gluten Free". I buy 95% of mine at a Health Food Store. I would like to see more dressings for salads.
4. Gluten-free" printed on a product label totally influences my decision to purchase a product.
5. I have been diagnosed with Celiac Spruce for almost 30 years. It has been a real challenge for me to eat, and recently realizing I am ingesting gluten from derivitatives on product that are hard to understand.


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Hello Everyone, I have a problem uploading a wordpress theme and I really need your help. I was trying to upload a theme in wordpress category, but I got two errors: 1. WordPress Theme is required 2. WordPress Theme style.css is missing Version header.
In main file, I had selected the zip containing files and in Wordpress Theme, I selected again ZIP containing main files.
Please help me to get out of this problem.
In your downloads page here select " installable WordPress files only" option and try that zip folder
Just realised you have no buyer badge so you will have to use the account which purchased the file
I think this is actually related to upload a theme for sale?
You need to upload 2 files, one is a .zip of everything, theme, documentation etc.
The other is a WP Theme .zip only and needs to be ready for someone to download and install straight to WP.


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Enjoy, I know I did.
Enjoy, I know I did.
Last edited by Hastings; 2013-01-04 at 03:15 AM.
I should be writing! | MAL
Not that funny, but enough to make me smile.
i'm going to hell for laughing at this.
Last edited by metaladdict; 2013-01-05 at 07:53 PM.
Some might get the feel joke some might not xD
Asus Z170-DELUXE - Intel Core i7 6700K - Corsair H110i - HyperX Predator 16GB 3200MHz DDR4 - EVGA GTX 1070 SC - Corsair RM850x - Corsair Graphite 780T - Asus Xonar DX2 - HyperX Savage 480g SSD - Seagate 3TB External HD
Vestigé - Protection Warrior - Vésty - Blood DK - Vestey - Guardian Druid - Currently Playing in Ravenous on Silvermoon 10/10 NH Mythic
sometimes, they like to remember where they left off, perhaps they liked the place. Don't say there are times you forgot a website, and were glad you had it in the browsing history. Saving the site as a bookmark doesn't keep it safe, so what would the point be to private browsing?
If you're too lazy to click once or twice, you deserve to have your browser history shown, quite frankly.or are just too lazy to use private browsing.


text:
v About the Oxford DNB
v Free Oxford DNB
v Your public library and Oxford DNB
v London & Londoners in the Oxford DNB
v Central Londoners in the Oxford DNB
> Home
> Latest update
> Free biographies by email
> Public library subscribers in the UK and Ireland
> Free trials for institutions
> Online: how to subscribe
Here you'll find people who've shaped the history of central London—from 'Big Ben' and the Globe to the capital's first coffee house.
Choose a label to read (or listen) on. 'More central Londoners in the Oxford DNB'
©Getty Images, G. Braun, Civitates orbis terrarum, 1575?
The complete ODNB includes the stories of over 58,000 men & women who've shaped British history, worldwide. Online access is available free—anywhere, any time—via nearly all UK public libraries.
Use People Search to find Londoners by date and by place of birth, education, residence, death or burial (requires online access, via UK public libraries). For example:
You may also be interested in...
> Read the Oxford DNB, free and at home, using your library's subscription
> More about the Oxford DNB
>Back to top


text:
IDEAS. IMAGE. INFORMATION. Combined with quality, creativity and commitment, they form the basis of Kent Creative. We will help you create the right image, convey key information, and capture your audience with interesting, memorable materials. We are also good listeners. We believe listening is the first step toward good creative.
ABOUT CRYSTAL KENT. Crystal Ward Kent, principal, started Kent Creative (formerly Kent Communications) in 1990. She has more than 20 years of experience in writing, art direction, and marketing. She also does extensive free-lance writing and has written for newspapers, magazines and books, including Yankee Magazine, Guideposts Books Listening to the Animals series; Guideposts Be Not Afraid, Their Mysterious Ways and A Glimpse of Forever. Her work also appeared in Chicken Soup for the Soul Christmas Treasury for Kids (December 2002). Click here to read her essay The Journey. Click here to visit The Journey for Animals.


text:
By Jack Kim
SEOUL (Reuters) - Park Geun-hye, daughter of the founder of modern-day South Korea, has been bumped off the top place in opinion polls of potential candidates for president for the first time in three years.
Park received 40.7 percent of support as a potential presidential candidate, trailing software developer Ahn Cheol-soo with 41.5 percent, a poll of 500 respondents by the Chosun Ilbo newspaper showed on Thursday.
Analysts said the surge by Ahn, a pioneering computer software developer who has never held elected office, reflected deep public distrust of the political establishment and exposed Park's vulnerability to a challenge from the left.
"It's safe to say Park's runway victory is now hardly a certainty," said political analyst Yu Chang-seon.
"What's ahead is Park having to go through fierce competition and we shouldn't rule out Ahn's candidacy."
Park, who stepped into the role of first lady when an assassin's bullet meant for her father Park Chung-hee killed her mother in 1974, had been by far the most popular choice to be the next leader of Asia's fourth largest economy.
South Koreans go to the polls next year to elect a new parliament in April and to pick a new president in December.
Park, who had led the ruling Grand National Party (GNP) previously and favors fiscal conservatism, had led in polls with more than 40 percent support.
But new polls showed she was behind Ahn within the margin of error. Ahn had never been considered a potential candidate for public office before he emerged as a possible candidate for mayor of Seoul.
Ahn, who founded the online security firm Ahnlab, has declared he would not run for the mayoral office in a by-election in October and backed an independent liberal candidate instead, boosting his popularity past previous frontrunners.
He has not spoken publicly on policy but is generally considered a liberal.
Park, 59, has called for tax cuts for businesses to spur investment and jobs, and advocated tailored welfare programs to encourage work for young people, increase the country's lagging birth rate, and improve the quality of life for the elderly.
She has also expressed a willingness to engage North Korea more than the incumbent President Lee Myung-bak, saying positive overtures from Pyongyang must be rewarded with concrete steps to softening the mood of confrontation between the rivals.
Soft-spoken and cautious in demeanor in stark contrast to her autocratic father who was assassinated by his spy chief in 1979, Park has consistently been one of the most popular political figures since election to parliament in 1998.
(Editing by David Chance and Yoko Nishikawa)


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Welcome to goldbuyersof.com where you get the best value for your gold, silver and other precious metals. If you've ever wondered whether that old gold ring or silver serving tray has any value then now's the time to find out. The precious metals market is booming with fantastic deals when you sell your gold jewelry, rare coins and silver serve ware for cash. Even items you think may have only sentimental value could actually be rich in gold, silver or platinum making it worth far more than you thought. At goldbuyersof.com we give you the best and most honest price for your gold.
We offer top dollar payouts based fixing rates for gold jewelry including bracelets, rings, watches, chains, pendants and even broken jewelry pieces. We also buy scrap gold including rods, plates and wires. We give you cash for your gold flatware including spoon, knife and fork sets, serve ware and trays. We also buy silver and platinum precious metals in all kinds of conditions. Show us what you got.
We are honest and fair with all our cash payouts for gold, silver and other precious metals as well as the calculations we use to determine our cash payouts. If you have a rare coin collection, old jewelry or scrap metals that have real gold, silver and platinum you may have a valuable commodity that is worth cash. Let goldbuyersof.com asses your gold, silver and platinum and give you the chance to trade your gold for cash.


text:
This product is no longer available.
Green Emerald Ficus - Root over Rock
Roundish dark green shiny leaves form rosetts at the end of its branches if kept trimmed. Branches and fruits well, and easily develops aerial roots when kept humid. Thick leaves make it different from other Ficus varieties.


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Pendulums-Relative Motion
A pendulum swings above a table. The table is also a pendulum that swings at right angles to and has the same period as the first pendulum. When both pendulums are set swinging at the same time, the observer sees the relative motions of the two pendulums in the frame of reference of the table. The relative motion can be linear, circular or elliptical depending on the phases and amplitudes of the pendulums. The visitor starts the pendulums swinging and controls their relative phase. This exhibit makes Lissajous patterns mechanically.
Composition Of Perpendicular Motions
Conservation Of Energy
Energy - Kinetic
Energy - Potential
Frame Of Reference
Natural Frequency
Oscillation - Coupled
Periodic Motion
Phase Angle
Polarization - Circular
Simple Harmonic Motion


text:
Comcast Petros TN
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text:
Autism: What we know. What is next?
This project begins a conversation concerning what we know and what we need to learn about autism and related developmental disorders. SFARI's chief scientist, Gerald Fischbach, wrote the original draft, with the intent of providing an outline of recent research advances and suggestions about next steps. The document incorporates several different methodologies, ranging from molecular biology to behavior, in hopes of building bridges between them. We hope it will serve as a valuable resource for experts in autism research and also as a helpful guide for those just entering the field.
Neither the claims about what we know nor the questions raised are complete lists. Autism research is advancing rapidly. In our hopes that "What we know" will become a living document, we invite you to suggest additions, deletions, corrections or wholesale rearrangements.
Explore the various sections below or download the entire document as a PDF here.
Please email your comments to G.D. Fischbach at [email protected]. And please check back for future iterations of this document as it expands and evolves.
Note on use of the term 'autism': For simplicity, throughout 'What we know,' we use 'autism' as shorthand for 'autism spectrum disorder,' as defined in the Phenotype section.
I. Phenotype
II. Epidemiology
III. Genetics
VI. Neural Circuits
VII. Therapeutics
1 May 2014: The first version goes live.


text:
New Orleans is currently on a roll. Memories of 2005's disastrous Hurricane Katrina and the US Government's scandalous response to it are becoming less raw. Last year Hurricane Sandy missed the city, and the Superbowl made a triumphant return there this year with Beyonce and Destiny's Child providing the half-time entertainment.
We stayed in the city for a stopover en route to Los Angeles. Internal flights are so frequent you could easily combine New Orleans with a visit to New York or Florida, or just drive down from Memphis.
Taking us into the city from Louis Armstrong airport, our taxi driver told us how he and his family had spent two days on the roof during Katrina. It seemed that everyone had a hurricane story to tell.
It may have been a brief visit but we'd planned an ambitiously packed programme of sightseeing.
We began by checking into the central Westin hotel, where our room had a view over a magnificent stretch of the Mississippi. We were in good company – Arnold Schwarzenegger was staying there at the same time while he filmed upcoming thriller The Tomb.
Eating gumbo with gusto
We had pre-arranged a selection of lavish meals, the first of which took us to Bourbon Street.
At GW Fins, the No 1 New Orleans restaurant on TripAdvisor at the time of writing, we got our first taste of the city's famous seafood. We enjoyed gumbo and grilled black drum fish, followed by freshly-baked apple pie with a Cheddar-flavoured crust.
The next morning we went to the New Orleans School of Cooking for a two-and-a-half hour demonstration. We were shown how to make gumbo, jambalaya, pralines and the dessert Bananas Foster, with the results shared around, accompanied by lots of beer, iced tea and lemonade. The lesson – costing a reasonable £14.50 per person – included a fascinating introduction to the city's history through its food.
From there, we went on a walking tour of the French Quarter – New Orleans's oldest and most famous area. Our guide Mary pointed out little-known landmarks, like the apartment where Tennessee Williams wrote A Streetcar Named Desire, and showed us features like the wrought-iron balconies and manhole covers which make the city unique. She also pointed out interesting museums. The tour is a good way to get inside the smartest restaurants, bars and antiques shops without having to buy anything.
For just £2, you can get a day pass for the city's trams, and we took a 1920s' Streetcar up St Charles Avenue through the Garden District of houses built by rich Americans after they took control of New Orleans from the French in the early 1800s. The view is a one-off, with three miles of beautifully-preserved mansions in the shadow of giant trees strung with Mardi Gras beads.
Dinner was taken in one of the smartest restaurants, Galatoires, and I was glad I had uncrumpled a jacket from my suitcase when I saw other men being handed comically-oversized garments before they were allowed in. Over Oysters Rockefeller – a pureed spinach and herb sauce on top of an opened oyster and grilled – one of the 100-plus-year-old restaurant's owners regaled us with tales of their celebrity guests.
He told us: "I'm a Republican, so when Bill Clinton came in last year, I gave him a cigar and said, 'I think you like these, Mr President'." I felt a bit sorry for Clinton having to listen to a 15-year-old joke.
New Orleans is that rare place in America – a city where people walk. But while you're in the area, do take a trip into rural Louisiana.
After a half-hour coach ride, we boarded a boat to marvel at turtles and alligators in the state's bayous. Children got particularly excited when our guide taped up the jaw of a baby alligator he had brought along and passed it around for us to hold.
It was good to get away from the temptation of food. That morning, still recovering from dinner, we had sat down to the city's most famous breakfast – a three-course blow-out at Brennan's restaurant. I'd chosen turtle soup, eggs Benedict, then crepes, flambeed at our table. A range of breakfast cocktails, referred to as "eye-openers", was also on offer.
With the jetlag retreating, we were determined on a big night out. Just east of the French Quarter, away from the tourist traps, is Frenchmen Street where jazz aficionados are well catered for. But walking past the dozen or so venues, you also hear funk, blues and soul music. If you're not sure where to go, it's best to wander up and down to see what sounds good. But we were enthralled by the entertainment in the street itself when a brass band, made up of teenagers with trombones, trumpets and giant sousaphone tubas, stopped the traffic. They were playing, dancing, singing, rapping and beat-boxing, sparking an impromptu party – just what you hope for on a visit to New Orleans.
We had time for a look round the Louisiana State Museum for more of the city's history, before squeezing in a trip to the famous St Louis Cemetery No 1. All bodies are buried in mausoleums above ground because the city's position below sea level means a flood could result in them being ejected from the ground.
Giant mausoleums erected for particular communities look like ornate stone filing cabinets with drawers for each body.
The following day we walked along the Mississippi to the French Market's coffee stand, Cafe Du Monde, for our final breakfast of donuts – or rather square beignets covered with far too much sugar, washed down with chicory-heavy coffee. It was certainly the icing on the cake and, as we relaxed in the sunshine, we agreed we would return, but for a much longer visit.
When to go
Any time of year, unless you want to avoid the heat and humidity of summer and early autumn.
Satchmo Summerfest, from August 1-4, is a free festival marking the birthday of one of the city's most famous sons, Louis Armstrong.
Coolinary New Orleans runs throughout August and celebrates food, with restaurants offering meals at special prices.
The Mardi Gras is on March 4 next year .
The Jazz & Heritage Fest runs from April 25 to May 4.
Do try
For a light bar meal go for half a dozen oysters – they are much cheaper than in the UK.
Getting around
The city is small enough to walk, take a taxi or hop on a vintage streetcar (a three-day pass is £6).
Top tip
Make a virtue of the lack of direct flights from the UK by adding New York or Chicago to your trip.
Book it
BA flights with one stop cost around £550 return. Rooms in the Westin New Orleans Canal Place start at £140 per night.


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Major research in the lab aims to understand molecular mechanisms involved in hereditary hemochromatosis (HH), the most prevalent genetic disorder in the western world. The disease is mainly caused by mutations in the HFE gene, which codes for a MHC class I like molecule. Work from our lab and others demonstrated that HFE is required for appropriate hepatic expression of the iron hormone and anti-microbial peptide hepcidin: expression of this negative regulator of duodenal iron absorption is decreased and cannot be appropriately adjusted in response to elevated hepatic iron levels in Hfe-deficient mice and HH patients.
These findings further our understanding of the molecular mechanism of Hfe function and suggest that the primary locus of Hfe function is the liver and not the duodenum, as was previously hypothesized. Indeed, using tissue-specific Hfe knock-out mice we recently unambiguously demonstrated that local Hfe expression in hepatocytes serves to maintain physiological iron homeostasis, answering this longstanding question in medicine. Using the conditional Hfe knock-out mouse lines established we now will investigate additional, especially extra-hepatic functions of the broadly expressed Hfe protein.


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Find Your Cruise
Cunard sail Southampton to New York and fly back to UK, but am sure you could fly to any part of Canada instead even if you are not returning.
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An Eden pub is racking up awards - its latest gong being singled out by the Good Hotel Guide.
The Black Swan in Ravenstonedale was named on Monday as the Best Pub with Rooms 2013 - two weeks after winning AA Pub of the Year.
The country pub is run by owners Alan and Louise Dinnes, who are overjoyed and have put their success down to great beer, wonderful staff and a central hub for the community.
Louise said: "We are absolutely delighted to have won two prestigious National awards in such a short time period.
"The Good Hotel Guide Award is particularly special to us as it is a totally independent Guide where hotels are unable to purchase entries and is very highly regarded in the Industry. "


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Missions volunteers along Rio Grande 'pay it forward'
- August 26, 2008
- By Analiz Gonzalez, Buckner International
But this summer, Matthew's mother, Susan Yow, and his 15-year-old sister, Lauren, joined the brigade of more than 300 Baptists heading south to serve in the Rio Grande Valley's colonias through KidsHeart, a collaborative mission effort between the Cooperative Baptist Fellowship, Buckner Children & Family Services and Buckner Border Ministries.
Altogether, the intensive mission effort included 422 volunteers from 29 churches and groups. Buckner and CBF officials reported 33 individuals made professions of faith in Christ during the two-week KidsHeart project.
In addition, the teams worked on 17 construction projects; painted homes, churches and a park facility; distributed backpacks, shoes, clothing, hygiene kits and other supplies to families; and led Vacation Bible Schools involving more than 900 children and adults.
While on the mission trip, Susan and Lauren Yow hammered and spray painted. Mrs. Yow shopped for school supplies for colonia children.
Lauren took a break from shoveling to talk about her brother. She stood in a half-finished park in front of Primera Iglesia Bautista in Sullivan City while her friends from First Baptist Church of Lorena continued working.
The flowerbed they dug and the benches they spray-painted will commemorate Matthew. The money came from funeral donations.
"Just because you lose someone doesn't mean you have to lose what they're about," Lauren said. "The benches mean a lot, because they show how everyone mourns for me and my family."
Lauren, who participated with her church at KidsHeart last year, said she came back this year because she wanted to serve.
"I feel like I've made a difference in these kid's lives by being here," she said, adding her brother's death spurred her mom to action, too.
Mrs. Yow said she was drawn to the Valley by the "incessant need to do for others."
"We had such an outpouring of cards, phone calls and people showing up at our house that we felt like we wanted to pay it forward," she said.
"My son was a loving, giving person. And in a way, I feel like this carries on his life.
"We can take two paths. We can be bitter, or we can be better. And the difference is 'I.' I feel truly blessed."
"God doesn't bless us because we are good," Zapata told Rodriguez. "He blesses us because he is good."
Rodriguez nodded in agreement and said he wants to return to God. The three bowed their heads and prayed together.
At another site in Puebla de Palmas, 17-year-old Kelly Rogers from First Baptist Church in Graham said she enjoyed serving the community through painting, fixing gardens and leading Vacation Bible School.
"If I wasn't here, I'd probably be working as a waitress or … nothing." She paused. "This is way better than what I'd be doing."
First Baptist Graham Youth Minister Jason Hilliard, 29, said the trip has brought a lot of growth to his youth group.
"It's good for them to see that God is spanning all languages and cultures," Hilliard said. "One of our guys is learning to play guitar, and he was strumming 'Shout to the Lord.' The kids jumped in and started singing in Spanish. It's really neat, God being praised in different languages."
Rick McClatchy, CBF Texas coordinator, said the volunteers help those who need it and, as a side bonus, they grow in their own spiritual formation.
"Having Jorge (Zapata) and Cheyenne (Solis) and other Buckner people on the field helps us know where to send teams to. The CBF angle is bringing labor and workers, while Buckner finds local churches and communities that we can work with when we show up," McClatchy explained.
Children from the Rio Grande Children's Home, a Buckner residential program in Mission, also worked on KidsHeart projects.
By the end of the work day, they were spotted from head to toe with blotches of paint and sweat. Paul Calmes from First Baptist Church in Oklahoma City sat them down outside the house to pray for them and thank them for their good behavior and teamwork.
"We could not have done this without your help," he told them. "I think that's what life is all about. You set an example, and I'm so grateful. I'm grateful for you being here with us. I'm going to be praying for you and not just for a little while, because you're in our hearts now."


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Mountain Tour Arrangements
Tours of the Mauna Loa Observatory may be scheduled by appointment only. Due to busy and constantly changing work schedules, tours may only be scheduled within 2 weeks of the requested tour date. Tours are available primarily on Monday and Thursdays when scheduling permits. To inquire about a tour, please contact Aidan Colton by email or 808-933-6965. Thank you for your request.
Office Tour Arrangements
The MLO office in Hilo is mainly administrative, but there is a small visitor center with displays of atmospheric research equipment and results. Guided office tours with hands-on displays can be arranged on selected weekdays. Office tours have been used in the past as activities for school groups and classes. To schedule a tour, contact Aidan Colton by email or phone 808-933-6965. Please try to make your request a few weeks in advance.
Transportation Needs
Transportation is not provided for you to the mountain site, or to the MLO office, due to federal policy. All housing and transportation needs must be arranged on one's own.
Useful Information
Mauna Loa Observatory is a remote, high-altitude facility. Reviewing the information below is strongly recommended to ensure your visit is safe and you are well prepared.
If you must cancel a trip after a visitation has been confirmed, please contact your MLO tour representative as soon as possible.


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Robot Arm
Team Robot Arm
Our project involves using a mechanism to sense the motion of a person's arm. This mechanism will send a signal to MatLab, which will then send a signal to a robot arm, causing it to move in a similar manner.
Possible Example, not finalized
First of all, the robotic arm is really cool. We wanted use our knowledge of Matlab to design a robotic system that would mimic actual human motion. Secondly, the applications for a human controlled arm are practically endless- exoskeletons, bomb deactivation, medical applications, etc.
Planned Timeline
- 11/19
* Code version 1 (elbow control) complete
- 11/21
* Human elbow instrumentation complete * Mechanical elbow joint and mount complete
- 11/24
* Systems integrated, elbow complete
- 12/5
* Human shoulder instrumentation for 1 D.O.F complete * Mechanical 1 D.O.F. shoulder complete * Code version 2 (elbow, 1 shoulder D.O.F.) complete
- 12/6
* Systems integrated, presentation-ready
Parts and Equipment Required
Mechanical Arm: Elbow:
E5 servo parts
E5 servo parts
Human Instrumentation: Elbow:
Stock materials (1/8" Al plate, 1/32" Al plate, 1/16" wall Al T-bracket, 1/2" Al rod, ass. fasteners) Machine shop time Linear potentiometer
Stock materials (80/20? Easystruct? Al/steel square tubing? Ass. fasteners) Machine shop time Linear potentiometer
Actual Timeline
- 11/19
* Calibration code and servo control code complete. Calibration was done using the law of cosines.
- 11/24
* Reading the potentiometer code and translating to angle code complete. The overall code tested, most of the kinks resolved. * The upper arm portion of the mechanical device for the potentiometer complete. * We all met to begin design of the actual robot arm.
- 12/1
* We met and calibrated a servo motor to the potentiometer to make sure it worked properly. * At first, we had an issue where the servo motor did not move the full rotation of the potentiometer. * Also, we modified the Readpoten code, and amazingly got the servo motor to respond in a similar fashion to the potentiometer!
- 12/5
* The lower arm portion of the mechanical device for the potentiometer complete. * We all came together to calibrate the our mechanical elbow mount to the actual robot arm. * We had trouble at first due to the result of imaginary numbers as outputs from Matlab. * This was soon discovered to be just a calibration error.
- 12/7
* All got together to complete the presentation.
Human Sensor
- Designed to hold a potentiometer over the rotation axis of the elbow
- Machined in Swarthmore machine shop from aluminum bar stock (plates), aluminum sheet goods (potentiometer bracket, made on brake), and steel square tubing and aluminum L-bracket (potentiometer interface)
Human calibration
This was done by picking two points on the mechanical mount for the shoulder and measuring the distance between them. This was done repeatedly to create a line of best fit. Then, using the law of cosines allowed matlab to measure the angle between them.
Matlab Code
% This script takes input from the user and uses it to calibrate % a motor connected to channel 1. clear all;
s=instrfind; %Find any serial links (we can have only 1) delete(s); %... and delete.
%Create a new serial communications link s=serial('COM1','Baudrate',115200,'Terminator','CR'); fopen(s); %... and open it
disp(' '); disp('Program starting.'); disp(' '); calibValues = [zeros(2,5)]; b=input('Enter leg1 length'); a=input('Enter Leg2 length'); for i=1:5;
pw=input('Enter pulse width: '); % get user input calibValues(1,i) = pw; cmd=['#1P' num2str(round(pw)) '#2P' '1150' 'T250']; fprintf(s,cmd); disp(['cmd = ' cmd]); disp(' '); position = input('Enter Distance '); calibValues(2,i) = acos((b^2 + a^2 - (position)^2)/(2*a*b));
y = polyfit(calibValues(1,:),calibValues(2,:),1);
calibEnd = [y(1), y(2)];
save('CalibrationMatrix','calibEnd'); disp(' '); disp('Program ending.');
s=instrfind; %Find any serial links (we can have only 1) delete(s); %... and delete.
%Create a new serial communications link - don't worry about details, %ask professor Cheever if you would like details. s=serial('COM1','Baudrate',115200,'Terminator','CR'); fopen(s); %... and open it
b=input('Enter leg length : ');
calibValues = [zeros(2,5)];
for i=1:5
dist=input('Enter distance : '); calibValuesArm(2,i)= acos((2*b^2 - (dist)^2)/(2*b^2)); fprintf(s,'VC'); %Inquire from connection "C" rtKnob=fread(s,1); %Read potentiometer value. calibValuesArm(1,i)=rtKnob;
m = polyfit(calibValuesArm(1,:),calibValuesArm(2,:),1);
calibEndArm = [m(1), m(2)];
save('CalibrationMatrixArm','calibEndArm'); disp(' '); disp('Program ending.');
s=instrfind; %Find any serial links (we can have only 1) delete(s); %... and delete.
%Create a new serial communications link - don't worry about details, %ask professor Cheever if you would like details. s=serial('COM1','Baudrate',115200,'Terminator','CR'); fopen(s); %... and open it
load CalibrationMatrix.mat; load CalibrationMatrixArm.mat;
loopTm=100; %Amount of time we will be looping. startTm=clock(); while etime(clock(),startTm)<loopTm,
%Don't worry about details of next four lines. Talk to professor %Cheever if you would like to know more. fprintf(s,'VC'); %Inquire from connection "C" rtKnob=fread(s,1); %Read potentiometer value. %[rtKnob]%Put values in display solely to be displayed. %theta = ((rtKnob - calibEndArm(1,2))/(calibEndArm(1,1))); theta = calibEndArm(1,1)*rtKnob + calibEndArm(1,2); time = .01; pw = ((theta - calibEnd(1,2))/(calibEnd(1,1))); cmd=strcat('#1P',num2str(pw),'T',num2str(time)); fprintf(s,cmd); %pause(0.01); %Wait just a short time.
end %The loop ends here.
beep; %Signify that we are done.
Although we did not get as far as creating the shoulder, our project successfully meets the original goal of creating a mechanical robotic system that perfectly mimics the motion of a human elbow. Using a linear potentiometer secured within a mount that can be attached to a human arm allowed to accurately collect data representing the motion of the arm about the elbow. This data was successfully transmitted to Matlab, which sent a signal to our robot arm. We had success in having the robot mimic both the motion up and down, and the speed of this motion.


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Building self-sufficiency throughout the world.
The worldwide demand for cleft repair surgery is staggering and can only be met if we build a self-sustaining network. Education, training, medical equipment, volunteerism and building a vital network of partner countries give children with facial deformities the chance for a new life, a new future.
While we work daily to plan and carry out medical missions from our U.S. headquarters each year, we reached a tipping point several years ago. Now, the majority of our medical missions originate from our partner countries — they are developing the volunteer base and resources on their own to carry out our work at the local level. Our dream of self-sufficiency is becoming a reality.


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Film and TV star Warwick Davis took time out to speak to the Wimbledon Guardian this week ahead of his starring role alongside Priscilla Presley in pantomime Snow White and the Seven Dwarfs.
The film and TV actor, whose credits include Willow, Star Wars, Harry Potter and more recently appearing with Karl Pilkington in the new series of an Idiot Abroad, will be taking on the role of chief dwarf Prof alongside rock and roll royalty Priscilla Presley as the wicked Queen and comedian Jared Christmas as Herman the Henchman.
How have rehearsals been going for Snow White and the Seven Dwarfs?
WD: "It's a huge show - we are basically staging a west end show in three weeks.
"It's quite technical and there is a lot of stuff going on behind the scenes that we hope the audience won't see.
"When we have been working on a show for three weeks you need an audience because that's what panto is all about.
"We have everything else in place but now we need the audience to bring it all together.
"It's exciting and I'm pleased with the script and everything.
"I haven't done panto since I was last here in Wimbledon about five years ago."
What was it like working with Priscilla Presley?
WD: "She is an amazing lady, very graceful and really had quite an introduction to the world of panto.
"She is a television and film actress but has not graced the stage before so she has had a very steep learning curve.
"You have to understand the very unique British and humour and innuendos and also understand working on a stage when your performance has to be larger than life and project to the audience rather than having a camera following what you have done.
"I have been helping her with that and we have a wonderful director."
Have you always been a fan of panto?
WD: "I have been a fan since I was a kid.
"For many kids panto is their first introduction to theatre and I want to make sure its the best experience it can be so they will continue to come and see theatre.
"In Wimbledon we have a full band and it's a real big sound so as an actor you feel really supported by the show.
"There is something I do at the end that's worth the ticket price alone.
"You will never see it coming and it's been quite a challenge to put on."
What was it like working with Karl Pilkington for An Idiot Abroad?
WD: "I travelled a bit for work over the years but never to these sorts of places and we were really off the beaten track.
"I didn't know what to expect but I was determined not to get ill.
"Karl said you're never going to cope with this and that just made me more determined.
"I was the only one not to get ill which I think annoyed Karl.
"Then he tried to make me ill by trying to make me eat all these weird foods.
"It was an amazing experience and one of the best in my career to do all those amazing things and meet all the people.
"India is an amazing country, full of life and colour and vibrancy - it was an incredible place.
"People always ask me is Karl really like that and I say of course he is like that.
"What you see is what you get.
"He's a lovely bloke.
"I think it's refreshing that he says what he thinks.
"He doesn't have a filter he just says it how he sees it.
"He's not always right, but some time he is.
"When you are working on something so long and travelling everyday when people are actually coming out and watching it that's what makes it worthwhile."
What have been your career highlights?
WD: "Star Wars has got to be a highlight, Willow of course and beyond that the Harry Potter films.
"Being part of all of those films was a great honour.
"Life's Too Short (BBC comedy series by Ricky Gervais and Stephen Merchant about life as a dwarf) got people talking and thinking.
"It aggravated some people but ultimately I think we made a fantastic show that made people think about what life is like for somebody who is short so I'm hugely proud of that."
Snow White and the Seven Dwarves; Friday, December 7 to Sunday, January 13; 7pm; £10 to £29.50; atgtickets.com/wimbledon; 0844 871 7646


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- Makes original sounds from the movie when you squeeze it
- Plush, soft and great for snuggling up with
- Requires 3 x LR44 cell batteries for operation (included)
- Length (approx.): 38cm (15")
- Country of origin: China
- For ages 0+ years


text:
The Power of Religion in the Public Sphere represents a rare opportunity to experience a diverse group of preeminent philosophers confronting one pervasive contemporary concern: what role does—or should—religion play in our public lives?
Reflecting on her recent work concerning state violence in Israel-Palestine, Judith Butler explores the potential of religious perspectives for renewing cultural and political criticism, while Jürgen Habermas, best known for his seminal conception of the public sphere, thinks through the ambiguous legacy of the concept of "the political" in contemporary theory. Charles Taylor argues for a radical redefinition of secularism, and Cornel West defends civil disobedience and emancipatory theology.
Editors Eduardo Mendieta and Jonathan VanAntwerpen detail the immense contribution of these philosophers to contemporary social and political theory, and an afterword by Craig Calhoun places these attempts to reconceive the significance of both religion and the secular in the context of contemporary national and international politics.
Each of the core essays was originally presented as a talk at a symposium co-sponsored by the Social Science Research Council, the NYU Institute for Public Knowledge, and the Humanities Institute at Stony Brook University. The book also includes edited transcripts of dialogues between Butler, Habermas, Taylor, and West, which—along with the original audio—can be found below.
Translations of the text have been made into Dutch, German, and Spanish. Continuing the discussion at The Immanent Frame, Akeel Bilgrami responded to Charles Taylor's chapter in The Power of Religion in the Public Sphere, offering an alternative conceptualization of secularism in an SSRC Working Paper. Bilgrami's working paper elicited a series of reactions of its own.
• Read an excerpt from Jürgen Habermas's chapter on "The Political."
• Read an article on the book by Scott McLemee in Intellectual Affairs.
• Read James Swindal's review in Notre Dame Philosophical Reviews.
• Read Peter Gordon's review in The New Republic.
• Read Christopher Lane's use of the book at The Huffington Post.
• Purchase The Power of Religion in the Public Sphere at Amazon.com or Powell's Books.


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Home > National News > Article
Consumers will pay the price for the federal government's failure to get sugar access for Australian farmers into the corrupted United States market.
Trade Minister Mark Vaile today conceded it would be taxpayers who ended up covering the cost of a sugar industry rescue package the government is mounting to help growers.
And he left open the chance of increasing the three cents a kilogram levy already in place to cover a previous sugar rescue package.
It follows agreement on a free trade deal between Australia and the US last week that failed to include sugar, despite earlier assurances from Mr Vaile and other senior government ministers.
Mr Vaile said the deal would be a major boost to the entire Australian economy, with a study done for the South Australian Labor government estimating it would be worth at least $500 million a year.
He said just as governments had helped other industries survive through a period of transition, the sugar industry deserved assistance.
But taxpayers would have to cover that help.
"All we can say is obviously any package to assist an adjustment process with the sugar industry is going to rely on taxpayer support, whether it comes by way of a levy or whether it comes by way of direct government support, because in the end they're taxpayers' dollars," he told the Ten Network.
"I'm not saying that it could be dearer for consumers.
"Australians enjoy some of the cheapest and best quality food in the world, and that's something that we should recognise because of the work that our farming community does."
Agriculture Minister Warren Truss last week ruled out extending the sugar levy to cover the proposed rescue package.
But Mr Vaile was not so keen to rule out an extension of the levy, which is similar to a tax on milk that is raising $1.8 billion for the dairy industry.
"I'm just saying ... that the government has to address this in consultation with the industry and we need to put in place measures to ensure the survival of a sugar industry in Australia," he said.
Debate is continuing about the economic benefits of the trade deal, with the government yet to decide which organisation will model the agreement.
A report by the Allen Consulting Group for the SA government found even a deal without full free trade in agriculture would be a boost to all states and territories except the ACT.
It estimated the boost at around $500 million, and did not take into account some elements of the agreed trade deal.
But the report also warned of job losses of up to 500 in NSW, Victoria, South Australia and the ACT.
Two other pre-agreement reports found the deal would either boost the economy by $4 billion a year, or actually reduce national income.
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Ashton Jenks aspires to take part in the next giant leap for mankind by being a space shuttle pilot and possibly visiting Mars.
"I think I'll be just the right age when they want to send someone," said the 10-year-old Clements/Parsons Elementary School fifth-grader. "It would be neat to be a pilot."
Ashton received a scholarship to attend Space Camp in Huntsville, Ala., last September through the National Organization for Albinism and Hypopigmentation, or NOAH.
Even though she attended the camp more than four months ago, Ashton can still recite the name of the chemicals used to power the space shuttle going to the international space station.
"Monomethylhydrazine and nitrogen tetroxide," Ashton said. "My friend (at Space Camp) kept repeating it, and other people memorized it."
Ashton has albinism, an inherited condition that causes a person to have little or no pigment in their eyes, skin or hair, requiring more caution when going into the sun. It can also sometimes affect vision.
"It makes me not see as well," Ashton said. "I always have to sit in the front row."
Despite the impairment, Ashton works hard to perform well in her classes, earning a spot on the A/B honor roll last semester.
Her science teacher, Denise Smith, said Ashton is an exceptional student.
"You can tell when she gets excited (to learn something). You can see it in her eyes and she talks a little fast," Smith said. "She's never a student to complain and finds ways to overcome challenges."
Ashton's favorite subjects are science, math and history, and she said she would consider archaeology if piloting a space shuttle doesn't happen.
Exploring space is a bigger goal for her, however.
"I want to go to Mars," Ashton said. "I also like (to learn about) Saturn and Neptune because they're pretty, and I don't think Pluto is a dwarf planet."


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London Thamesport (LTP) is located in the heart of South East England, 10 miles from
the M2 motorway, 35 miles from London. It is one of the UK's busiest container
ports. LTP is a member of the Hutchison Port Holdings (HPH) Group.
HPH, a subsidiary of the multinational conglomerate CK Hutchison Holdings Limited, is the world's leading port investor, developer and operator. The HPH network of port operations comprises 319 berths in 52 ports, spanning 26 countries throughout Asia, the Middle East, Africa, Europe, the Americas and Australasia. Over the years, HPH has expanded internationally into other logistics and transportation-related businesses. These include cruise ship terminals, airport operations, distribution centres, rail services, and ship repair facilities. In 2013, the HPH port network handled a combined throughput of 78.3 million TEU worldwide.
Thamesport (London) Limited trading as London Thamesport (Registered in England No. 2191687).
Registered Office: Tomline House, The Dock, Felixstowe, Suffolk IP11 3SY
Maritime Transport Services Limited (Registered in England No. 2398922).
Registered Office: Tomline House, The Dock, Felixstowe, Suffolk IP11 3SY


text:
» What is the Hazard Mitigation Grant Program - Backgrounder
COLUMBIA, S.C. -- The public and local officials are invited to attend one of two meetings scheduled for next week to provide their personal input into the State's plan to reduce future disaster risks, federal and state disaster recovery officials announced today.
The meetings, administered by the state's Interagency Coordinating Committee (ICC), will provide the public an opportunity to discuss priorities for mitigation opportunities available to South Carolina as a result of Hurricane Floyd. Initial estimates indicate that more than $5 million in federal funds from the Federal Emergency Management Agency (FEMA) will be available on a cost-share basis for approved community projects to reduce future disaster risks.
Conway will be the site of the first meeting on Thursday, Nov. 4, at 6 p.m., at the Conway City Hall (Council Chambers) located at 1001 Third Ave. The second meeting will be held on Friday, Nov. 5, at 6 p.m. in North Charleston at Strett Hall Building Auditorium, 1530 Seventh Street at Hobson Ave. on the old Charleston Navy Base.
"These meetings will give people and local officials in the area a chance to indicate which priorities are most important to them," State Coordinating Officer and ICC Chairman Stan McKinney said. "The input will play an important role in refining the state's mitigation strategy and may help to shape mitigation outcomes."
FEMA's Hazard Mitigation Grant Program (HMGP) will cover 75 percent of the total costs of approved mitigation projects, and the South Carolina Emergency Preparedness Division administers the program. The total amount available for the HMGP equals 15 percent of federal funds spent on the Infrastructure and Individual Assistance Programs in South Carolina following President Clinton's major disaster declaration on September 21.
The ICC is comprised of representatives from the Governor's Office and four state agencies. The purpose of the committee is coordinate disaster mitigation efforts


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Reed (plant)
From Wikipedia, the free encyclopedia
Reed is the general botanical term used for tall, grass-like plants of wet places. They occur in reed beds. They are all members of the order Poales.
Reeds are a whole collection of polyphyletic species, which have all adapted to this wet habitat by convergent evolution.


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Newborn Graeme Loveland was born into the world via a toilet in his parents' home, WMUR-TV in Manchester, N.H., reported.
The unusual delivery shocked Justin and Nicole Loveland, who shared their story and brave reaction after their son arrived unexpectedly.
Newborn Enters World Into Parents' Toilet
Current Status: Blessed (1)
Seeded on Wed Jan 20, 2010 3:59 AM
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General Information
Dates: February 3 – 7, 2015
Host: Darton State College and Albany State University
Location: Albany, GA
Details: The Albany Municipal Auditorium will serve as our primary performance venue.
Darton College is located on a 180-acre campus in Southwest Georgia, a region known for its year-round warm climate. The city has been ranked by Money Magazine as the best place to live in Georgia and among the top 115 places to live in the United States.
The largest indoor municipal destination south of Atlanta, the Albany Civic Center is a uniquely designed multipurpose convention, entertainment, trade show and meeting facility.
- Festival Schedule
- Workshop Descriptions [PDF]
- Festival Program [PDF]
- Hotel Information
- Festival Technical Specs
- Award Recipients


text: They might be small, but the two pendant lamps hanging above the kitchen island are punching way above their design weight. Their witty echoing of the extractor hood's distinctive angle adds an elegance that can't be discounted. Thoughtful but understated details like this are the essence of brilliant lighting design.


text:
Virginia Restores Voting Rights for Returning Citizens
Virginia Governor Bob McDonnell signed an executive order to restore voting rights for non-violent felons.
Now it's up to the Virginia State Legislature to make permanent – through an amendment to the state constitution – the restoration of voting rights for all citizens.
The NAACP applauds Governor McDonnell's decision to eliminate the application process and allow for automatic registration for all citizens. But more fights for the voting rights of returning citizens are on the horizon; in Florida, North Carolina, Kentucky, Delaware, and Iowa. That's why we need your help advocating for voting rights restoration.
Join us by signing our petition supporting the restoration of voting right.
The NAACP has fought a long battle for the restoration of rights--and we will continue to fight alongside politicians, social justice advocates, and most importantly, with you, to continue to shine light on the need for restoring voting rights for ALL.


text:
Return to article: Study by former MSU grad student reveals changing diets for Yosemite bears
For editorial use only in conjunction with the direct publicity or promotion of Montana State University, unless otherwise noted. No other rights are granted. Commercial use is prohibited. All rights reserved.
To download the high-resolution version of this image, use your browser's Save or Download Image feature, found by right-clicking (PC) or control-clicking (Mac) on the image.


text:
CFP - Carolinas' Summer Fight Series, Fight #1
CFP - Carolinas' Summer Fight Series, Fight #1 - Mixed Martial Arts (MMA) Event on May 22, 2010 in Wilmington, North Carolina USA
This is the first of a series of three fights held in the Carolinas during the Summer of 2010! This fight will feature the best amateurs and pros from the Southeast. On this card, we have knock-out sensation, Derek Brunson, as well as past Ultimate Fighter contestant and local boy, Brandon Garner. The goal at Carolina Fight Promotions is to produce the best MMA events around, and you definitely don't want to miss this highly anticipated event! So, make a day of it and head to the beach in the morning and come to the fights at night!
Directions: The fights will be held at the Schwartz Center in Downtown Wilmington, NC.


text:
noun phrase
The head (1932+)
Or maybe they did it so Paul Ryan getting booed throughout his speech to AARP wouldn't be the top story.
The ground floor served as drawing-room; above it was the anchoret's bedroom; and the top story was used as a study.
A Spanish woman in the top story of the hospital heard the firing.
The top story of all held the machinery connected with the turning of the sails.
Here, in the top story of the building, is the room of the type-setters.
Suddenly, at one of the windows in the top story there appeared a woman.
"Let us see what's the matter," said the landlord; and he lifted off the top story.
The third and top story will be one tent, which forms the peak of the pyramid.
The heat was intolerable in the rooms, for it was the top story of a small house with the sun beating against the roof.
And so the top story is conduct, based upon the beliefs, and inspired by the emotions.


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A week-long series of thunderstorms and rain showers will give way to dissipating clouds and sunshine heading into Utah's weekend.
While a Flash Flood Watch remained in effect for the eastern third of the state through Thursday night, drier weather was to rule beginning Friday.
The Wasatch Front looked for highs around 90 degrees on Friday, the same as forecast for Thursday.
Southern Utahns were on schedule to see Thursday's partly cloudy skies give way to sunny horizons on Friday, with highs then in the mid-90s — up a few degrees from Thursday's forecast.
The Utah Division of Air Quality rated the entire state in the "green," or healthy air quality category heading to the latter part of the work week.


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Hugo's the victor in box office race
Page Tools
Actor Hugo Weaving.
Photo: Simon Alekna
Australians may hate their own movies at the moment but they love their own actors, as long as they're in movies made overseas.
An analysis of the most successful films ever shown here suggests that the actor most likely to tempt Australians to the cinema is Hugo Weaving. His box office total of $270 million - from the Lord of the Rings series, the Matrix series, Priscilla and Babe - far exceeds the $175 million earned by the top American, Tom Hanks (Forrest Gump, Saving Private Ryan and eight others).
An analysis of the 270 films that have grossed more than $10 million at the Australian box office appears in the News Review section of today's Herald.
Only 18 of the all-time hits are Australian-made (topped by Crocodile Dundee, Babe and Moulin Rouge). But 54 have Australian-trained actors or directors, such as Mel Gibson (What Women Want), Geoffrey Rush (Pirates of the Caribbean), Peter Weir (The Truman Show), Bryan Brown (Cocktail), Gillian Armstrong (The Piano), Nicole Kidman (The Others), Toni Collette (The Sixth Sense), Hugh Jackman (X-Men), Eric Bana (Troy), Russell Crowe (Gladiator), Natalie Imbruglia (Johnny English), and Olivia Newton-John (Grease).
Based on box office totals, the 20 most bankable actors for Australian audiences include three American women (Julia Roberts, Cameron Diaz and Drew Barrymore), three Englishmen (Orlando Bloom, Ian McKellen and Hugh Grant), and three Australians or former Australians (Weaving, Gibson and Rush).
The most successful American men are Tom Hanks, Robin Williams, Eddie Murphy and the less familiar Bill Paxton (who had significant roles in such hits as Titanic, Twister, True Lies and Vertical Limit).
Get the SMH delivered for as little as $3 a week - SAVE 21%


text:
This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Most of the current knowledge on antiretroviral (ARV) drug development and resistance is based on the study of subtype B of HIV-1, which only accounts for 10% of the worldwide HIV infections. Cumulative evidence has emerged that different HIV types, groups and subtypes harbor distinct biological properties, including the response and susceptibility to ARV. Recent laboratory and clinical data highlighting such disparities are summarized in this review. Variations in drug susceptibility, in the emergence and selection of specific drug resistance mutations, in viral replicative capacity and in the dynamics of resistance acquisition under ARV selective pressure are discussed. Clinical responses to ARV therapy and associated confounding factors are also analyzed in the context of infections by distinct HIV genetic variants.
The human immunodeficiency virus (HIV) has been characterized in 1983 as the causative agent of the acquired immunodeficiency syndrome (AIDS) [
HIV belongs to the
HIV-1 is responsible for the AIDS pandemic and can be divided into four groups (M, N, O and P), each one derived from a distinct introduction of SIVcpz in the human population (
Summary of HIV types and groups
|Isolates (%)1
|259,678 (98.2%)
|All continents with exception of Antarctica
|Major group responsible for the AIDS pandemic; more fit than HIV-1 group O and HIV-2.
|SIVgor or SIVcpz
|1,095 (0.4%)
|Majorly found in Central and West Africa
|Naturally resistant to NNRTI; less fit than group HIV-1 M and HIV-2.
|Recombinant group M ancestor / SIVcpz
|22 (<0.001%)
|Only found in Cameroon
|Very rare epidemically; few studies on drug resistance published.
|Single case
|Described in 2009 in a Cameroonian woman. The actual number of infections is unknown.
|3,593 (1.4%)
|Mainly found in Western and Central Africa; some cases in Western Europe, India, United States, Brazil and Japan
|Apparently slower progression to AIDS; less susceptible to some anti-HIV-1 drugs; naturally resistant to NNRTI.
1. Isolates sequenced and available at the Los Alamos HIV Sequence Database as of 18 July 2009.
In the early 1990s the sequencing and alignment of viral genes
With the advance and popularization of DNA sequencing techniques, new genomic regions were obtained and analyzed, including HIV-1 full-length genomes. All HIV strains previously classified as subtype E based on
According to the current classification, HIV-1 group M is divided into nine different "pure" subtypes or non-recombinant forms (A-D, F-H, J and K) [
The worldwide distribution of HIV-1 subtypes is very heterogeneous, with regional prevalence of specific variants (
HIV-1 molecular epidemiology is dynamic over time. For example, subtype C was dated to have entered Brazil in early 1980s [
Worldwide prevalence of HIV-1 group M subtypes and CRF.
In March of 1987, AZT (zidovudine) was the first HIV-1 drug approved by the U.S. Food and Drug Administration (FDA) for AIDS treatment. Between 1991 and 2007, 24 additional drugs were approved, divided into five classes, according to the viral protein target (
HIV eradication from infected subjects is still a distant scenario, but the currently available treatment provides better quality of life to HIV/AIDS patients, minimizing viral replication, promoting partial recovery of the immune system and, thus, delaying or halting disease progression [
With the advent of HAART, effective viral load suppression can be maintained for many years [
Summary of antiretroviral drug classes.
|Drug Class
|Release year
|Nucleoside/Nucleotide Reverse Transcriptase Inhibitors (NRTI)
|NRTIs are mimetics of nucleosides/nucleotides and bind to the active site of the polymerase domain in the viral RT enzyme, inhibiting the synthesis of double-stranded viral cDNA
|Zidovudine (AZT)
|Didanosine (ddI)
|Zalcitabine (ddC)
|Stavudine (d4T)
|Lamivudine (3TC)
|Abacavir (ABC)
|Tenofovir (TDF)
|Emtricitabine (FTC)
|Protease Inhibitors (PI)
|PIs are mimetics of viral peptides and bind to the active site of the protease enzyme, preventing viral maturation in a late step of virus life cycle
|Saquinavir (SQV)
|Ritonavir (Rtv);
|Indinavir (IDV)
|Nelfinavir (NFV)
|Amprenavir (APV)
|Lopinavir (LPV/r)
|Atazanavir (Atv);
|Fosamprenavir (fAPV)
|Tipranavir (TPV)
|Darunavir (DRV)
|Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTI)
|NNRTIs are designed to bind to an RT hydrophobic pocket, modifying its structure allosterically and impairing the polymerase domain catalytic site
|Nevirapine (NVP)
|Delavirdine (DLV)
|Efavirenz (EFV)
|Etravirine (ETR)
|Entry Inhibitors (EI)
|EIs are small peptides that bind to envelope viral proteins (gp41 or gp120) and prevent the fusion between viral envelope and cellular membranes or virus attachment to co-receptors in early steps of the virus life cycle
|Enfurvirtide (T-20)
|Maraviroc (MVC)
|Integrase Inhibitors (II)
|IIs bind to the viral integrase and prevent the integration of the viral double-stranded cDNA into the host cellular genome in the early steps of the virus life
|Raltegravir (RAL)
Currently, drug resistance mutations (DRM) have been described for all drugs in clinical use. In the polymerase domain of RT 13 positions were correlated with loss of drug susceptibility to NRTI, and 14 positions to NNRTI. In the protease (PR) region, 38 positions interfere with PI susceptibility. Seven positions in gp41 are associated with fusion inhibitor resistance and three positions in the viral integrase are related to II [
An important issue extensively discussed in the last years relies on the impact of ARV drugs in different HIV-1 subtypes. This concern is based on the fact that the great majority of the studies conducted on HIV drug design, acquisition of drug resistance mutations, genotyping for drug resistance evaluation, and the phenotypic impact of DRM on HAART have been performed primarily for subtype B strains. Such concern has been particularly strengthened by two reasons. The first is the introduction of HIV treatment in African countries, where more than two-thirds of the people with HIV/AIDS live and where the HIV epidemiology is largely dominated by non-B HIV-1 subtypes (
HIV-1 non-B subtypes represent a challenge to HAART treatment as there are scarce studies in the literature on the efficacy of treatment in the context of infection by these subtypes. Different HIV groups and subtypes carry in their genomes genetic signatures and polymorphisms that could alter the structure of viral proteins which are targeted by drugs, thus impairing ARV drug binding and efficacy. HIV-2, for example, is less susceptible to some PIs, such as amprenavir, ritonavir and indinavir [
Various non-B HIV-1 group M subtypes present genetic signatures and polymorphisms in their protease which are considered as compensatory DRM in subtype B (
Genetic signatures and/or polymorphisms of HIV-1 non-B subtypes associated with resistance to PIs.
|Drug-associated mutation
|% in Subtype B
|90%–98% in subtypes A, G and CRF02
|4%–78% in other subtypes non-B
|93%–98% in subtypes G and CRF02
|1%–3.5% in subtypes A, F and CRF01
|ATV, IDV, NFV and TPV
|81%–99% in several non-B subtypes
|96%–97% in subtypes A, C and G, CRF01 and CRF02
|2% in subtype F
|87% in subtype G
|1%–6% in several non-B subtypes
|94% in subtype C
|5%–40% in several non-B subtypes
In recent years, a few studies have been conducted on drug susceptibility of different HIV-1 subtypes from treatment-naïve subjects. They have shown that drugs belonging to the PI, NRTI and NNRTI classes are highly efficient in inhibiting HIV-1 non-B subtypes [
With the advent and dissemination of HAART in countries where HIV-1 non-B subtypes are prevalent, studies in DRM acquisition have accumulated over recent years. Viral isolates of HIV-1 non-B subtypes from patients under therapeutic failure primarily contain the major DRMs known for subtype B to PR and RT inhibitors [
With respect to NRTIs, the frequency of mutations related to resistance to thymidine analogues (TAM) also show differences between subtypes. There are two well known distinct resistance pathways to thymidine analogues: TAM-1, which includes mutations M41L, L210W and T215Y; and TAM-2, characterized by mutations D67N, K70R, T215F and K219Q/E [
Treatment regimens containing the NRTI 3TC, ABC, FTC, TDF and ddI can select the uncommon DRM K65R [
With respect to NNRTIs, a study among pregnant women using single-dose NVP for mother-to-child transmission prophylaxis in Uganda and Malawi showed that the proportion of viral resistance to that drug was higher in subtype C (69.2%) than in subtype A (19.4%) and D (36.1%) isolates [
Some of the results described above remain inconclusive because there was no assessment of the extension of treatment exposure and the specific drug regimens of the individuals analyzed. Differences of B and non-B subtypes in acquiring specific DRM could be due to differences in those parameters; for example, more prolonged exposure of patients infected with subtype B to monotherapy and dual therapy, mostly available in subtype B-predominating countries in the first decade of the HIV/AIDS pandemic. As the use of HAART is more recent in developing countries, non-B subtypes have been less exposed to mono- and dual therapy, and may acquire DRM at a slower pace. At the same time, other factors can influence such differences, such as viral fitness in the presence of DRM, genetic barriers, kinetics of DRM emergence, subtype-specific mutations (SSM), polymorphisms and differential impact conferred by the same DRM in different subtypes. Those factors will be discussed in further detail below.
Although many compensatory DRM can be naturally found in treatment-naïve isolates as polymorphisms or genetic signatures in different HIV-1 subtypes, the sites at which major DRM occur are highly conserved in HIV-1 group M isolates. The acquisition of viral resistance often implies structural modifications within or close to the enzyme's active site, allowing the protein to better discriminate its natural substrate in the restrictive environment imposed by drugs. The cost to this advantage is generally paid through loss of replicative capacity. The frequency of major DRM can be inversely correlated with its cost to viral fitness,
Evidence that different HIV-1 subtypes can present distinct resistance fitness in the presence of drugs was observed, for example, for NFV. According to the IAS consensus, viral isolates under NFV pressure can select D30N or L90M [
Another well documented example of how specific mutations can impact differently on virus replication is that caused by TAM pathways in HIV-1 subtypes B and C. Differences were described for the impact on fitness when a single TAM was introduced in these subtypes [
It is conceivable that the fitness cost is a potential cause of some differences in DRM acquisition in distinct HIV-1 subtypes. However, studies in this theme are still scarce in the literature. Future studies with new infectious clones of different HIV-1 subtypes will help to elucidate this interesting subject.
The genesis of drug-resistant variants is caused by random mutation events in viral genomes during the reverse transcription step of the virus life cycle. The change of a nucleotide at a definite codon can translate into amino acid changes. Therefore, the frequency of a DRM could be directly related to the number of modifications in the genetic code needed for the acquisition of the amino acid conferring resistance. HIV-1 subtypes have silent mutations in their coding sequence that could favor the emergence of distinct mutations in a definite subtype or group of subtypes (
Drug resistance mutation and genetic barriers for HIV-1 group M subtypes
|Codon Position
|Resistance mutation
|Codon change
|Genetic barrier in non-B subtypes
|GTC → GCC (1 ts); GTC → ACC (2 ts)
|G: 14% GTC; Other subtypes: 87%–100% GTC
|ATC → GCC (2 ts); ATC → ACC (1 ts)
|G: 84% ATC; Other subtypes: 0%–9% ATC
|GTT / GTC / GTA → ATT / ATC / ATA (1 ts); GTG → ATA (2 ts)
|G: 63% ATA; Other subtypes: 0%–6% ATA
|CAG → ATG (2 tv); CAA → ATG (1 ts, 2 tv)
|D: 37% CAA; F: 83% CAA; Other subtypes: 2%–12% CAA
|TTG → TGG (1 tv); TTA / CTG → TGG (1ts, 1 tv); CTA → TGG (2 ts, 1 tv)
|C: 30% TTA / CTG; F: 50% TTA / CTG and 23% CTA; G: 82% TTA / CTG; CRF02_AG: 83% TTA / CTG; Other subtypes: 82%–87% TTG
|GTG → ATG (1 ts); GTA → ATG (2 ts)
|C: 83% GTG; Other subtypes: 0–7% GTG
|GTA → ATA (1 ts); GTG → ATA (2 ts)
|G: 62% GTG; Other subtypes: 88%–100%
Data extracted from reference [103]; * Secondary DRM; ts – transition; tv - transversion
Yet another interesting case of genetic barrier for DRM and subtypes is the NRTI mutation K65R. It was shown that in HIV-1-infected cell cultures treated with TDF, that mutation was selected more rapidly in subtype C (12 weeks) than in subtype B (34–78 weeks) [
Genetic barrier may explain some cases of differential emergence of DRM. Nonetheless, the mutational cost to acquire major DRM is generally similar in the most prevalent HIV-1 subtypes and CRF (A-D, F, G, J, CRF01_AE and CRF02_AG). This indicates that genetic barrier is not the sole cause of differences in DRM acquisition observed among HIV-1 subtypes.
Another potential mechanism to explain distinct prevalence of DRM between subtypes is differential kinetics for DRM acquisition across drug exposure time. However, there are only a few studies on this issue to date. Such studies nevertheless showed some interesting differences. For example, in Brazil, it has been shown that subtype C isolates from patients under antiretroviral treatment accumulate lower rates of DRM to NRTIs and PIs than isolates of subtype B [
The explanation behind this phenomenon remains unclear. Studies about fitness in major DRM for non-B subtypes are yet scarce as previously discussed. These studies show that in some cases, non-B subtypes had a lower frequency of DRM acquisition across treatment exposure time than subtype B, for which all available drugs have been designed.
Another possible explanation for the differential kinetics of DRM acquisition between subtypes would be the emergence of subtype-specific mutations (SSM) that compensate for the lower proportion of recognized DRM compared to subtype B. The first SSM described was M89I/V for subtypes C, F and G [
Other mutations have also been correlated with treatment, such as those at PR positions 6 (subtype C), 15 (CRF02_AG), 19 (subtype F), 37 (subtype A) and 64 (subtype C and CRF01_AE), in addition to RT position 102 in subtype C [
Subtype-specific mutations require careful phenotypic characterization, since the identification of mutation as a major DRM will drastically change the resistance genotyping interpretation for a given subtype or group of subtypes. Most importantly, the correct interpretation of SSM will better guide treatment in countries where non-B subtypes prevail.
HIV-1 subtypes have genetic signatures and amino acid polymorphisms that cause conformational changes at their proteins and such hindrances can facilitate or impair the acquisition of definite DRM. Interesting examples are mutations N88D and N88S in PR. They are both selected under NFV pressure. However, in clinical isolates of subtype B with at least either mutation D30N, N88any or L90M, or a combination of these, N88D was present in 21.2% of patients, compared to a prevalence of N88S in only 5.2% of patients [
The classification of DRM into major or compensatory mutations is exclusively based on data generated with subtype B. For example, mutation L90M in PR of subtype B is considered major to NFV and SQV and compensatory to other PI [
Differential resistant phenotypes have also been observed in subtypes B and C carrying the PR mutation T74S. This mutation was described as compensatory, increasing the replicative capacity of PI multiply-resistant viruses of both subtypes [
In the viral RT, mutation K65R conferred a more pronounced resistant phenotype to ABC, 3TC and ddI in CRF01_AE than in subtypes B and C [
Subtype-specific protein backbones, in addition to affecting fitness or facilitating DRM acquisition, can also confer different resistance levels to definite HIV-1 group M subtypes. Studies in this area are novel and can help improve current genotyping algorithms, essential to guide better salvage regimens in patients failing therapy.
With the expansion of antiretroviral treatment throughout the world, HAART has been introduced in countries where non-B subtypes are prevalent. This scenario created an opportunity to evaluate patients' response with respect to HIV viral load (VL) decrease and CD4+ T-cell recovery in the context of distinct HIV-1 subtypes. A study in Europe compared treatment response of European patients, all infected with subtype B, with that of African immigrants, the majority of which infected with subtypes A, C and D [
An important confounding factor present in several of the studies that compared the effect of subtype on treatment outcome is the ethnicity of the subjects. Even in cases where patients were enrolled from a single care site, differences in cultural aspects of individuals from diverse geographic locales or continents may play an important role in the outcome. Adherence to treatment is a clear example of those aspects. Indeed, one of the studies that found a "subtype effect" on treatment outcome was able to associate ethnicity with virologic responses [
HIV strains with higher genetic distances to HIV-1 group M seem to be more prone to failing clinical outcomes. A meta-analysis conducted with Belgian and Luxembourgian patients comparing clinical outcomes after 12 months of treatment upon HIV-1 or HIV-2 infection showed reduced immunologic and virologic responses in the latter group [
It is apparent from the abovementioned studies that first-line HAART regimens are similarly efficient in suppressing HIV VL and CD4+ T-cell recovery in patients infected with different HIV strains. Whether people infected with diverse subtypes have differences in clinical outcomes after long-term treatment remains to be elucidated.
As the technology for the achievement of HIV eradication and of the formulation of an effective sterilizing HIV vaccine are still beyond our knowledge, antiretroviral therapy is yet to be further disseminated in the next future, particularly in developing countries. As a consequence, the understanding of the impact of HIV genetic diversity on the development of drug resistance and on treatment outcomes is of pivotal importance. Such knowledge concerns not only to developing, but also to developed nations, where the proportion of new HIV infections by non-B subtypes is currently rising sharply. The use of antiretroviral drugs, originally developed for subtype B, is so far similarly promising in geographical areas where non-B subtypes circulate. However, only long-term studies assessing the susceptibility to antiretroviral drug regimens in settings where non-B subtypes occur will be of paramount relevance to trace the role of the described polymorphisms / molecular signatures in the dynamics of drug resistance acquisition.
This work is part of the requirements for A.F.S. to obtain his Ph.D. degree at the Graduate Program in Genetics of the Universidade Federal do Rio de Janeiro, Brazil. A.F.S. was supported by a Ph.D. fellowship from the Brazilian Research Council (CNPq). M.A.S. was supported by CNPq, by the Department of AIDS and Hepatitis of the Brazilian Ministry of Health, and by the Rio de Janeiro State Science Foundation (FAPERJ).


text:
> Which port does the WebGui from monowall use? Is it a different one than
> 80 or 443?
The WebGUI uses port 443 and is only accessible from the internal LAN. Do
you think that this conflicts with the NAT setting? Should I change the port
for the WebGUI?
Thank you,


text:
|Andreas Dilger <adilger@xxxxxxxxxxxxx>
|Re: Interface for the new fallocate() system call
|"Amit K. Arora" <aarora@xxxxxxxxxxxxxxxxxx>
|Fri, 20 Apr 2007 19:21:46 +0530
|linux-fsdevel@xxxxxxxxxxxxxxx, linux-kernel@xxxxxxxxxxxxxxx, linux-ext4@xxxxxxxxxxxxxxx, xfs@xxxxxxxxxxx, cmm@xxxxxxxxxx, suparna@xxxxxxxxxx, Andrew Morton <akpm@xxxxxxxxxxxxxxxxxxxx>, Jakub Jelinek <jakub@xxxxxxxxxx>, torvalds@xxxxxxxxxxxxxxxxxxxx
|<email@example.com> <email@example.com> <firstname.lastname@example.com> <firstname.lastname@example.com> <firstname.lastname@example.com> <email@example.com> <firstname.lastname@example.com> <firstname.lastname@example.com> <email@example.com> <firstname.lastname@example.com>
On Wed, Apr 18, 2007 at 07:06:00AM -0600, Andreas Dilger wrote: > On Apr 17, 2007 18:25 +0530, Amit K. Arora wrote: > > On Fri, Mar 30, 2007 at 02:14:17AM -0500, Jakub Jelinek wrote: > > > Wouldn't > > > int fallocate(loff_t offset, loff_t len, int fd, int mode) > > > work on both s390 and ppc/arm? glibc will certainly wrap it and > > > reorder the arguments as needed, so there is no need to keep fd first. > > > > I think more people are comfirtable with this approach. > > Really? I thought from the last postings that "fd first, wrap on s390" > was better. > > > Since glibc > > will wrap the system call and export the "conventional" interface > > (with fd first) to applications, we may not worry about keeping fd first > > in kernel code. I am personally fine with this approach. > > It would seem to make more sense to wrap the syscall on those architectures > that can't handle the "conventional" interface (fd first). Ok. In this case we may have to consider following things: 1) Obviously, for this glibc will have to call fallocate() syscall with different arguments on s390, than other archs. I think this should be doable and should not be an issue with glibc folks (right?). 2) we also need to see how strace behaves in this case. With little knowledge that I have of strace, I don't think it should depend on argument ordering of a system call on different archs (since it uses ptrace internally and that should take care of it). But, it will be nice if someone can confirm this. Thanks! -- Regards, Amit Arora
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text:
Alain Zürcher (firstname.lastname@example.com)
Fri, 30 Jul 1999 22:26:17 +0200
Ivan C. Chang wrote :
<< When I run htsearch for some keywords, it sometimes happens that the
results returned contained links that don't actually contain the keywords,
when this happens, the search results report the following statement:
(None of the search words were found in the top of this document.)>>
Easier solution as suggested by Gilles Detillieux : are you sure that your
keywords are not in the meta or title tags? (If you assigned some weight to
them or kept their default weights.)
| Alain Zürcher, Paris, France
To unsubscribe from the htdig mailing list, send a message to
email@example.com containing the single word unsubscribe in
the SUBJECT of the message.
This archive was generated by hypermail 2.0b3 on Fri Jul 30 1999 - 12:54:10 PDT


text:
A SWINDON mother claimed that paranormal activity was behind her two children's absence from school.
The 29-year-old, who lives in West Swindon, but cannot be named for legal reasons, was brought before Swindon Magistrates' Court on Tuesday after consistently failing to take her eight-year-old daughter and six-year-old son to school.
The single parent, who is on benefits, brought in priests and mediums to try to resolve the strange activity, the court was told.
The mother admitted the offences which occurred between January 1, 2008, and March 18, 2008, while the family was living in Walcot East. The case was brought by Swindon Council.
Simon Emslie, prosecuting, said that between those dates the girl had missed school on 23 out of 94 occasions giving an attendance rate of 67 per cent, while the boy had not attended 34 times out of a possible 94 – a 64 per cent attendance rate.
Despite the involvement of an education welfare officer, who made several phone calls, sent letters and arranged meetings and home visits, the attendance continued to fall, the court heard.
When the six-year-old was referred to the school nurse, his mother said she had been having problems getting him dressed and getting him to have breakfast.
Mr Emslie said there had been three previous convictions in 2007 for truancy matters, resulting in a conditional discharge.
Sambreen Arif, defending, said her client had not missed all the appointments, though she had been pregnant at the time, which had made it more difficult.
She said that the paranormal activities issue had been raised with the school.
Because the family lived in a council-owned property the mother had been unable to move straight away.
Miss Arif said: "She was trying to make her children go to school, but she accepts responsibility. It was not just a blanket 'I'm not sending them to school' – she did make some efforts."
The court was told that since the children had moved to a new school other family members had moved into the area.
Since then, the children's attendance had risen to 84 per cent for the eight-year-old and 79 per cent for the six-year-old.
In sentencing, Felicity Beard, the chairwoman of the bench, described it as a very difficult case.
She said the bench had taken into account the improvement, but they had also considered that the mother had not attended meetings and the breach of the conditional discharge.
"This is, as you now know, very serious. It's very important children go to school for all sorts of reasons," said Ms Beard.
The mother received a six-month supervision order and was ordered to pay £300 costs.
A council spokeswoman said: "We take unauthorised absence very seriously and when it occurs we work with the family and school."