text:
Canelo Alvarez: I'm not looking past Josesito Lopez
Don't let the red hair and freckles fool you.
Saul "Canelo" Alvarez -- the nickname translates to "Cinnamon" in English -- might remind you of Howdy Doody or Opie Taylor, but beneath that boyish exterior lies a rugged 22-year-old fighter with heavy hands and 41 professional fights already on his resume, and nary a loss among them.
Alvarez, whose good looks and advanced ring skills have earned him rock-star status in his native Mexico, jumps into the spotlight on Mexican Independence weekend when he puts his WBC 154-pound title on the line against seemingly overmatched challenger Josesito Lopez on Saturday night at the MGM Grand Garden Arena in Las Vegas (Showtime, 9 p.m. ET).
Alvarez will compete for that spotlight with another Mexican star. Julio Cesar Chavez Jr., son of the legendary boxer, will fight at the same time and in the same city, a mile or so down the road, when he meets Sergio Martinez in a battle of the world's best middleweights at the Thomas and Mack Center on the UNLV campus. That fight, on HBO pay-per-view, is the more attractive matchup of the two Saturday fights.
For those who follow Alvarez, and there are legions throughout Mexico and the U.S., this fight is just another step in his march to the top of boxing's hierarchy, and an eventual pairing with the top pound-for-pound fighters in the sport, such as Floyd Mayweather, Manny Pacquiao and Miguel Cotto.
There are many who believe Alvarez (40-1-1, 29 KOs) is looking past Lopez (30-4, 18 KOs) to a bigger fight and more lucrative payday. Canelo denies it, at least publicly, despite being as high as a 15-1 favorite.
"Josesito earned the right to be here," Alvarez says. "I'm not underestimating him at all.I want to continue on this path, but I have to get through Josesito first."
His most recent fight, in May against future hall of famer Sugar Shane Mosley, was an easy decision. But Mosley was twice his age and well past his prime. Alvarez also has stopped well-known older fighters Carlos Baldomir and Kermit Cintron, but those wins are a far cry from the upper echelon.
And Alvarez has been criticized for fighting Lopez, a much lighter man who has competed most of his career at 135 or 140 pounds and never has weighed in at more than 144. That was his weight for his stunning defeat of bigger welterweight Victor Ortiz, who had his jaw broken by Lopez in June.
Neither Lopez nor Alvarez is concerned about the weight differential.
"I walk around at a heavier weight, and it's been a different type of camp coming into this fight," Lopez said. "We've been working on a great nutritional dietary plan, and we're making some good meals and we feel a lot better, we feel a lot stronger. I know going into the fight I'm not going to look like a 154-pounder, but as long as I feel strong and the speed is still there, that's all that matters. . . . I'm excited because if you're basing my punching power on how I look, I think a lot of people are going to be surprised."
To add cache to the Showtime card, Golden Boy kicked in an extra $100,000 for the best knockout of the night, including the entire card. It's a nice chunk of change for any boxer outside of Mayweather and Pacquiao. But going for a quick knockout can blow a fighter's strategy, especially for a patient boxer such as Alvarez.
He said the bonus won't change his plan: "I never think about the knockouts," he says. "I go into every fight, do my work, and none of that stuff puts pressure on me at all."
Lopez, meanwhile, is just looking for any break to go his way. "With a win here, I think I could just fall over and die and be happy," he said, laughing. "I've come a long way, and I feel like this is just the beginning because I'm barely starting to get in my prime as a fighter," he says. "I've got to prove to the world that this poor, skinny Mexican from Riverside (Calif.) can do it."
Posted | Updated


text:
Niebuhr Center Students & the Chaplain's Office
Please join the Niebuhr Center on Monday, March 10 for a student lead and student organized christian campus worship service. Various students and facutly will be speaking and giving readings.
This event is free and open to the campus community.
Date: Monday, March 10, 2014
Time: 4:00 PM
Location: Hammerschmidt Memorial Chapel
Ticket Information:
General Admission: Free
Contact Information:
Name: Dr. Beauchamp
Phone: (630) 617-3490
Email: firstname.lastname@example.com

subset: commoncrawl


text:
Dr. Maya Angelou thinks you should vote:
As a country, we can scarcely perceive the magnitude of our progress.
My grandmother and my uncle experienced circumstances that would break your heart. When they went to vote, they were asked impossible questions like, "How many angels can dance on the head of a pin?" When they couldn't answer, they couldn't vote.
I once debated with the Rev. Martin Luther King Jr. about whether an African American would ever be elected president. He believed it would happen within the next 40 years at the time—I believed it would never happen within my lifetime.
I have never been happier to have been proven wrong.
And since President Barack Obama's historic election, we've moved forward in courageous and beautiful ways. More students can afford college, and more families have access to affordable health insurance. Women have greater opportunities to get equal pay for equal work.
Yet as Rev. King wrote, "All progress is precarious."
So don't sit on the sidelines. Don't hesitate. Don't have any regrets. Vote.


text:
Child Health and Sanitation Week 2008 to Help Reduce Child Deaths from Water-Borne and Other Diseases
Islamabad, 19 April 2008 – The National Programme for Family Planning and Primary Health Care, the Ministry of Health and the Ministry of Environment, in collaboration with UNICEF and other partners, will launch Child Health and Sanitation Week on Monday 21 April, providing free immunisation and deworming services for children and information to mothers and communities; focussing especially on exclusive breast feeding, use of Oral Rehydration Salts (ORS) in diarrhoea, sanitation, hygiene and safe drinking water. From 21 April to 26 April, a series of activities to reduce child deaths and disease by promoting better health, sanitation and hygiene practices will be launched in six districts across the country in Balochistan, the North West Frontier Province, Punjab and Sindh. Public awareness activities at village and union council level will be supplemented by immunisation and deworming for children, as well as anti-tetanus vaccination for pregnant mothers, refresher trainings for health workers, and strengthened public health systems to ensure that ORS and other essential supplies are available and correctly used.
"Every day, about 1,100 Pakistani children under five die of diarrhoea and diseases related to water, sanitation and hygiene," said Martin Mogwanja, UNICEF Country Representative for Pakistan. "This is a great concern and opportunity for UNICEF and its partners in the Government and civil society to raise awareness about the impact of poor sanitation and hygiene practices on children, families and communities."
To help prevent many of these deaths, UNICEF and its partners will mark the International Year of Sanitation, by focussing on three key messages: safe drinking water, hand-washing, and use of sanitary toilets. A series of awareness activities will help reach a wide range of community members. These include awareness walks, school activities, puppets shows, widespread television coverage, and door-to-door visits by Lady Health Workers to reach women in their homes. Throughout this week, religious leaders have been mobilised to deliver sermons on the importance of safe drinking water and hygiene practices.
By integrating sanitation awareness activities with the biannual Child Health Weeks, the Government, UNICEF and other partners hope to use the existing health system and staff to increase awareness at the very start of the summer, when children face higher risk to contract diarrhoeal diseases. In 2007, Child Health Weeks were piloted in two districts and achieved an increase in initiation of immunisation from 82 per cent to 96 per cent as well as 86 per cent coverage for deworming as shown by pre- and post-intervention surveys. Pakistan's Child Health and Sanitation Week follows a model applied successfully in Ghana, where regular health weeks were instrumental in halving under-five mortality within five years. By integrating child and maternal healthcare with other vital interventions, such as water, environment and sanitation, UNICEF and its partners hope to reduce Pakistan's high burden of child mortality at low cost using pre-existing infrastructure.
UNICEF is on the ground in over 150 countries and territories to help children survive and thrive, from early childhood through adolescence. In Pakistan, it works with the government, NGOs and other partners to support child health and nutrition, good water and sanitation, quality basic education for all boys and girls, and the protection of children from violence, exploitation, and AIDS. It has provided vital relief and reconstruction support to help individuals rebuild their lives after emergencies, such as the October 2005 earthquake. UNICEF is funded entirely by the voluntary contributions of individuals, businesses, foundations and governments.
For more information contact UNICEF's Communication Officers:


text:
Picture you and your partner as a beautiful painting. How would you treat an exquisite piece of art? You would most likely select a beautiful frame which compliments your 'painting', then carefully display it for friends and family to appreciate.
A gorgeous head table is a key element when planning your design and style. It is so important to add any details that make this personal. Fabrics (always different from guests, but complimenting: runners/overlays/lace/etc.) can distinguish your tables from your guests. Mirrors can add a heightened ambiance with a feeling of home or modern and clean bases for centrepieces. Candles generally look best in staggered heights (at least two different). Small handpicked, unique items (vases for bouquets, unique frames holding your menu [or on each place seating], napkin holders, fine china or unique glassware for you and your attendants).
The options are endless to create your unique space. Your head table should be what frames the most beautiful people at your wedding. This focal point or the "frame" of your reception should be:
1. Consistent with your theme (modern, vintage, traditional, etc.)
2. Be different from guest tablescapes, to add extra detail your space
3. Tie in the theme of your bouquets (generally displayed here)
4. Have a use of eclectic unique items
5. Be the main focal attraction of your room
6. Work in conjunction to balance the height and size of your backdrop (higher backdrop = complimenting higher features, shorter ceilings = longer and fuller table, etc.)
There is much to consider, and who doesn't want to make an impact? All of the above and much more we take into consideration when determining your personal vision and element of decor. Feel free to customize your head table... The possibilities are endless!
With Love Always,
Heidi & Jon-Paolo
your 45 Design team
Heidi & Jon-Paolo
your 45 Design team


text:
Mobilité quotidienne et vulnérabilité des ménages
The recent increase of gazoline price has relaunched the debates on the vulnerability of the households in situation of automobile dependency. This paper develops a methodology to calculate the portion of household income spent on daily mobility, from which a threshold of vulnerability is proposed. This method leans largely on databases available in most of big French conurbations, and in particular on the household trip surveys. An analysis of the socioeconomic and spatial factors explaining the variations of this household vulnerability has been conducted from the Bordeaux, Lille, Lyon and Marseille household trip surveys.
If you experience problems downloading a file, check if you have the proper application to view it first. In case of further problems read the IDEAS help page. Note that these files are not on the IDEAS site. Please be patient as the files may be large.
Volume (Year): février (2012)
Issue (Month): 1 ()
Pages: 19-44
|Contact details of provider:
| Web page: http://www.cairn.info/revue-d-economie-regionale-et-urbaine.htm
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text:
On View
Netherlandish; Possibly
Madonna and Child with Saint Barbara and Saint Catherine
Unknown artist, Netherlandish; Possibly
Madonna and Child with Saint Barbara and Saint Catherine, ca. 1525
Oil on panel
91.4 x 87 cm (36 x 34 1/4 inches)
Museum Works of Art Fund 58.196
This panel depicts a nursing Madonna and Child with two early Christian martyrs in attendance. Identified by their attributes, Saint Barbara reads before a tower while Saint Catherine holds a spiked wheel and sword, the instruments of her torture. At center, an angel offers a dish of figs, symbols of Christ and of the Virgin birth. The artist is unknown, but elements of this painting's style were practiced by followers of Leonardo da Vinci (1452—1519) from both Flanders and the Italian region of Lombardy. Here, the soft modeling and delicate faces that characterized Leonardo's portraits have been emulated. The Dutch inscription on Saint Catherine's robe and the brilliant detail of the costume and interior suggest that the panel was painted by an Antwerp master familiar with the work of Leonardo and of Milanese contemporaries.


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An Air Soft Case
A gun or firearm is defined by federal and Pennsylvania law to mean any weapon that is designed to fire a bullet or other projectile by means of an explosive. A firearm silencer or muffler is also included in the definition of a firearm, as is a destructive device and ammunition.
Federal and Pennsylvania definitions of a firearm do not apply to antique firearms, which include any firearm manufactured in or before 1898. Pennsylvania and federal definitions of a firearm do not include toys that fire plastic balls by means of compressed air or springs. A Hi Point carbine makes the cut, but thirty airsoft toys and a collection of blades do not. Super Soakers don't make the cut. Water hoses do not make the cut. Blenders do not make the cut. Two whole beef patties special sauce lettuce cheese pickles onions on a sesame seed bun doesn't make the cut either. So why are three law enforcement officials doing photo ops behind a table filled with toys guns and toy ninja swords? Could it be that they are trying to legitimize a faux pas with a sensationalized song and dance?
"I do not think an attack was imminent and I am not certain that an attack was going to occur at all," Bruce Castor stated. "It could have simply been big talking by a kid who thought that he was bullied previously and he was going to exact his revenge." Police found about 30 air powered guns, swords, knives, videos of the 1999 Columbine attack, books such as The Anarchist Cookbook, a U.S. Army counterinsurgency operation handbook, and notebooks filled with violent missives, Castor claimed. Also found was a Hi Point carbine, now known in the mainstream media as a "9mm assault rifle." No 9mm ammunition was found for the Hi Point carbine. Police also discovered several explosive devices described as homemade grenades: plastic containers filled with pellets to which gunpowder could be added at any time. Authorities said one grenade was operable and the others had been in the process of being assembled. I guess gunpowder could be added to the chicken salad in the tupperware beside the milk in the old Frigidare too. That would make a hell of a mess.
The boy's mother was charged today with unlawful transfer of a firearm, possession of a firearm by a minor, corruption of a minor, endangering the welfare of a child and two counts of reckless endangerment. She was later released on bail. Oh, by the way Bruce, it is not illegal for a parent to purchase their child a firearm.
So look Bruce, no doubt the boy had problems. Address the real issues. Don't try to manufacture a case where there is no substance. That only makes you look silly.
To read the exact legal definition of a firearm, go to 18 USC § 921- Definitions.
Information for Pennsylvania Firearms Purchasers & Basic Public Safety
Montgomery County District Attorney Bruce L. Castor Jr.
Pennsylvania Firearms Law
Labels: Gun Bias


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WORLD-OBITS-L ArchivesArchiver > WORLD-OBITS > 2005-09 > 1127846669
From: "Peter_McCrae" <>
Subject: LLOYD: Robert Francis-19/6/2002>USA/TX--obits,ancestry.com
Date: Tue, 27 Sep 2005 19:44:29 +0100
Robert Francis Lloyd
Born: May 23, 1922
Died: June 19, 2002
ROBERT FRANCIS LLOYD, age 80 of Nevada, TX, passed away June 19, 2002. He
was born May 23, 1922, in Elkhart, IN, to Harold and Mary (Van Tilberg)
Lloyd. Mr. Lloyd was a purchasing agent in the RV industry. He was a member
of the United Methodist Church in Elkhart, IN, the Vandalia Masonic Lodge
#290 of the Grand Jurisdiction of Michigan, Scottish Rite in Valley of Grand
Rapids, MI, and the Shriner-Saladin Temple in Grand Rapids, MI. He is
survived by his wife of 50 years: Mildred Rentfrow Pendill of Nevada, TX;
sons: Karl Pendill & wife Evelyn of Grand Saline, TX, and Steven Pendill &
wife Laura of Nevada, TX; brother: William Lloyd of Vandalia, MI; sister:
Marilyn Wickland of Scotia, NY; 10 grandchildren, 20 great grandchildren,
and 2 great-great grandchildren. He was preceded in death by his parents and
by 1 brother, Harold. Funeral services were held 2:00pm, Saturday, June 22,
2002, at Rest haven Funeral Home-Rockwall Chapel with Rev. Brad Elsom
officiating. Interment followed in Rest Haven Memorial Park. The family
received friends Friday evening at the funeral home from 6:00 to 8:00pm.
This thread:
|LLOYD: Robert Francis-19/6/2002>USA/TX--obits,ancestry.com by "Peter_McCrae" <>


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Wittenberg Student Discovers Passion For Service, Direction For Future
Springfield, Ohio – Although all Wittenberg University students must perform community service before enjoying their moment in the sun on graduation day in picturesque Commencement Hollow, not all students look forward to scheduling it. Chris Gipson, class of 2011 from Naperville, Ill., had participated in service events previously, but he was not eager to add a 30-hour service project to his work load.
"Honestly, I was not that hot-to-trot on the community service requirement," Gipson said. "I selected the Infusion Campus, an after-school program for elementary and middle school kids, grounded in fine arts, as my site choice. My background in the fine arts is not strong, although I have always thrived when working with kids. I entered Infusion on my first day hesitant and mild-mannered, and left four hours later enthused and inspired."
Many of the young boys attending Infusion Campus come from single-mother households and benefit from having a positive male role-model. Six years of experience coaching youth lacrosse players gave Gipson the background and skills necessary to relate with the boys in a constructive manner while having fun.
Gipson's time at the Infusion Campus was highlighted by an experience with a young boy from a single-mother home who was desperate for an older brother/father figure, and he quickly gravitated towards Gipson. One day at the beginning of a program, the speaker snapped her fingers as part of her talk. The child slid closer to Gipson to ask how she had done that.
"Initially, I was confused about what he was asking, but when he put his fingers together awkwardly, I gathered that he was trying to snap them," Gipson said. "Helping to position his hand properly, I showed him how to take his thumb and middle finger and strike them against one another. Third time was the charm as he made a distinct snapping sound. His entire face lit up in a smile."
The moment was an epiphany for Gipson as he realized the possibilities before him.
"Moments like these and people like everyone involved at Infusion are what helped me discover my calling in life," he said.
Gipson came to Wittenberg as a transfer student from Ursinus College in Pennsylvania the fall of his sophomore year. With a major in English and a political science minor, he has earned the Sigma Tau Delta International Honor Society for English and serves as the vice president of the honorarium. A Provost Scholar both Fall 2009 and Spring 2010 semester, he is also a Top-25 Junior Student Athlete. In addition, Gipson serves as a Peer Helper and a member of the Wittenberg Literature and Art Review staff.
With a passion for lacrosse, Gipson has been a member of Wittenberg men's lacrosse team for the past three years and is a member of the Chi Alpha Sigma National College Athletic Honor Society. He played a key role for the Tigers as they won the first North Coast Athletic Conference (NCAC) title in program history – he appeared in 14 of the team's 15 games, starting three, and he ranked seventh in scoring with five goals and five assists for 10 total points.
With plans to remain involved in non-profit organizations, Gipson hopes to eventually become a college admission counselor and lacrosse coach. Several months after beginning his community service requirement, Gipson became a student coordinator for the Community Service Office.
"I believe that by keeping an open mind students will be able to learn things about themselves that go way beyond the capabilities of the classroom," Gipson said. "For me, community service began as a requirement and rapidly became a passion that has positively altered the course of my life."
Written By: Phyllis Eberts and Amber Reyes '12
Photo By: Erin Pence


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Former Rep. Dave Weldon Enters GOP Senate Primary With Weird Running Video
The GOP primary for the Senate nomination has been nothing short of tumultuous this year, with several candidates jumping in and out of the race. For a while there, it seemed Rep. Connie Mack IV was about to cruise to victory thanks largely to the name he shares with his father, former Sen. Connie Mack. Now former Rep. Dave Weldon has made a last-minute entrance into the race. Literally, he envisions it as a race, and his first campaign video is a weird montage of people running.
He has more experience than Mack on the federal level and more conservative credentials. Can he pull of some of that Marco Rubio magic and bring down the fairly moderate and establishment-backed frontrunner in a primary?
Connie Mack IV's only real previous competition in the race was former Sen. George LeMieux. The two are now trying to claim that they're both the most conservative in the race. LeMieux's short voting record is actually more to the right than that of the pretty moderate Mack, but LeMieux can't seem to shake his ties to Charlie Crist. Mack meanwhile has had a hard time shoring up conservative support, and has lost a number of straw polls to LeMieux despite leading in money and general polls. Basically, both dudes are just a little bit whack.
Now Weldon has entered the race. He served as a representative from Florida's Space Coast from 1995 until early 2009 before stepping down as he "never wanted to be a career politician."
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But apparently he's decided he wants to further his career in politics after all.
His entrance into the race comes along with this trailer for a movie about a bunch of businessmen running to the bar after work before happy hour ends. Oh wait, excuse us, we were watching it with the sound off. Apparently they're all running away from Obama. Watch as they run, run, run into some secret enclave in the woods were they will all receive warm hugs from Weldon himself, or something. Strong, conservative manly hugs that will lower taxes and fix the economy.
We're not sure how effective this ad is, though, because as we all know no real American runs anywhere anymore. We're all too fat. Running is some effete, liberal, hippie crap. You know who runs? Michelle Obama runs. She runs while she eats arugula in sleeveless designer workout gear. True patriots do not run away from Obama. They get into their pick up trucks or motor scooters and drive away from Obama.
Though, if conservatives (especially those with money) really are uneasy with both Mack and LeMieux, they may be willing to overlook this strange physical exercise business. Weldon's only real chance is if Mack truly fails to please his base.
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text:
" The Elliott was made for comfort-lovers, you just sink into it. Plus I'm a huge fan of prints so I especially love the fleur-de-lys version - it feels elegant and fresh.
Seductive Seating
Low-backed, wide and inviting - this plump-cushioned 3 seater sofa sums up creature comfort. In an eye-catching fleur-de-lys print.
Striking Details
Subtle accents, like the turned feet in dark stain wood, add an elegant touch. Plus the pattern perfectly matches up.
Made for Relaxing
Upholstered by hand and super-comfy, with generous foam and fibre cushioning for a luxuriously soft sit. Scatter cushions included.
Versatile Statement
Makes a sophisticated standalone addition in a contemporary or traditional living room. For a complete set-up, team with the armchair.
" The Elliott was made for comfort-lovers, you just sink into it. Plus I'm a huge fan of prints so I especially love the fleur-de-lys version - it feels elegant and fresh.
Visit us
Want to see our furniture up close and personal? Our showrooms are open 7 days a week.
OUR CUSTOMERS' HOMESPrev Next
Questions about this product (2)
Lesley, 1 Dec 2012
I really like the look of the Elliott fleur de lys blue sofa, I'd like to know how blue it is? We're looking for a grey/cream colour scheme.
Lesley, 1 Dec 2012
Made Customer Services, 1 Dec 2012
The Fleur De Lys Blue does have tones of grey in it, but I would definitely describe it as a blue rather than a grey. It could look good with your colour scheme, but the Harrier Grey or Parchment Beige versions of the Elliot sofa might suit you better.
Made Customer Services, 1 Dec 2012
Andrew , 25 Dec 2012
My son is considering buying a 3 seater Elliott sofa, they live in an apartment where the entrance is a bit tight. Can you dismantle the arms on his item?
Andrew , 25 Dec 2012
Made Customer Services, 25 Dec 2012
I can confirm that the arms on the Elliott collection do not dismantle. The only thing on the sofa which is removable is the legs which will need to be assembled once delivered. You can find all the dimensions above, both with packing and without.
Made Customer Services, 25 Dec 2012


text:
Welcome to E-Books Directory
This is a freely downloadable e-book.
Acoustics And Architecture by Paul E. Sabine
Read this book online or download it here for free
Custom Search
Acoustics And Architecture
by Paul E. Sabine
Publisher: McGraw-Hill 1932
Number of pages: 358
Contents: Nature and properties of sound; Sustained sound in an inclosure; Reverberation theoretical; Reverberation experimental; Measurement of absorption coefficients; Sound absorption coefficients of materials; Reverberation and the acoustics of rooms; Acoustics in auditorium design; Measurement and control of noise in buildings; Theory and measurement of sound transmission; Transmission of sound by walls; Machine isolation.
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text:
TRANSITIONAL-GENEALOGISTS-FORUM-L ArchivesArchiver > TRANSITIONAL-GENEALOGISTS-FORUM > 2010-01 > 1264438654
From: "LBoswell" <>
Subject: Re: [TGF] was GPS, now The Phrase
Date: Mon, 25 Jan 2010 11:57:38 -0500
References: <firstname.lastname@example.com><406EAA3C0D6F4D4990B42E18E9ECB0AC@acer511eba12df><firstname.lastname@example.com>
In-Reply-To: <firstname.lastname@example.com>
I'm at wits end. I've no intention of flaming anyone but I get enough
ordinary spam, and enough is enough. I think flaming is more if I was to
initiate the abuse. I'm intend to paraphrase and make public the abuse,
without comment. It will stand on its own, unremarked. I don't mind
exchanging views, but when someone digs into my past with intent only to
discredit me, and accuse me of making dishonest claims, I will give them a
more public forum for their remarks
but with respect for Christy, that's my final word on this. The abuse
originates from the list, which is why I brought back to the list.
But the highroad has always been my choice. But there are limits to the
type of abuse I'm willing to endure. People will have the option to respond
to and defend their abuse on my blog. I won't edit their responses in any
way. I think that's a better venue for personal exchanges than private abuse
or abuse on the list.
I intend to conform to Christy's guidelines. I think if we all do that on
list and in any secondary off list conversations, we could have some good
discussions here.
----- Original Message -----
From: "Mary Douglass" <>
To: <>
Sent: Monday, January 25, 2010 11:49 AM
Subject: Re: [TGF] was GPS, now The Phrase
Let's agree to disagree on the following issue and move on.
I trust you're not referring to me. I don't make provocative statements
(with intent just to "provoke" in a negative fashion). I look at things and
make suggestions, offer opinions, try to discuss points of view. If I don't
hold to the idea of the BCG material being a foundational document of our
profession, that's not a hanging offence?
I'm not even skeptical of the BCG, I just see it as one possible attempt to
create guidelines. Not *the* set of guidelines, for me (and I suspect,
FYI: I also have a blog, but would never use it to flame someone who
disagrees with me. I chose to take the higher road.
Mary Clement Douglass
Your Kansas research specialist
URL: www.historical-matters.com
To unsubscribe from the list, please send an email to
with the word
'unsubscribe' without the quotes in the subject and the body of the message
This thread:
|Re: [TGF] was GPS, now The Phrase by "LBoswell" <>


text:
KPCC News In Brief
Absolut Vodka pays to clean up Walk of Fame
Vodka will clean up the Hollywood Walk of Fame. Absolut Vodka will help restore the deteriorating tourist attraction through a program called "Friends of the Walk of Fame." Hollywood Chamber of Commerce President Leron Gubler says other corporations will contribute money too.
Leron Gubler: "The city said basically there's not enough public sector dollars to do these repairs, we've got to identify private sector contributions, which is why we're manning that effort now to do that. And I'm sure the public is going to be appreciative that we're raising money rather than trying to tap into tax dollars when the budgets are in such bad shape."
Gubler says repairs will cost at least $4 million and be complete in two years – just in time for the Walk of Fame's 50th anniversary. In exchange for their contribution, Absolut Vodka received an honorary star on the Walk of Fame.
- July 22, 2008 2:15 PM
- Categories: Arts, Business/Economy


text:
"You'll pay too much if you use a Big Franchise Company."
We will go and give you a No-pressure estimate to repair or replace your main sewer line at no charge to you
A+ rating is an exemplary rating. This means there are no files that cause the BBB to have any doubt about our company's reliability.
That's right! At Fisher Plumbing we can quote most prices over the phone, saving you time and money!
Is a drippy faucet, hose bib or toilet causing your money to go down
the drain? Find out...


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Tag: stricklin
eMC – The Monologue
DOWNLOAD | The Tonite Show – eMC
Following the release of their second studio album "The Tonite Show", eMC return with a brand new video for the single "The Monologue". Masta Ace, Wordsworth and Stricklin have filmed the video in the favelas of Sao Paolo, Brazil, and continue to celebrate the release of The Tonite Show. Fans can still download The Tonite Show by clicking on the iTunes link listed above and also please ensure you join in on Twitter with the hashtag (#eMCDateWithJimmy). You can watch the video for eMC – The Monologue on the YouTube player below.
Category: Videos
eMC Announce New Album The Tonite Show
DOWNLOAD | The Turning Point – eMC
Hip-Hop fans rejoice! The legendary eMC crew (Masta Ace, Wordsworth and Stricklin) have announced the groups second album "The Tonite Show" will be released on the 5th of May 2015. The Tonite Show will be released via M3/Penalty Entertainment/Sony Red and promises fans more excellent music from eMC. Fans can still download eMC's "The Turning Point" from the iTunes link listed above, and watch Masta Ace, Wordsworth and Stricklin (eMC) talk about the upcoming album "The Tonite Show" on the YouTube player below.
Category: News, Upcoming Releases, Videos
Masta Ace, Wordsworth, Stricklin and Marco Polo LIVE Q+A
Masta Ace – Son of Yvonne | DOWNLOAD
This is an exclusive 45-minute Q and A session with Masta Ace, Wordsworth, Stricklin (eMC) and Marco Polo, filmed by Hip-Hop Kings and @CreationBeats at Sedgwick Avenue in Leeds. During the Masta Ace 2012 tour of the UK, he gave fans in Leeds a worldwide exclusive first listen of the album MA Doom: Son of Yvonne, and the opportunity to open questions to an audience of 100+. The full list of questions are placed in the description of the YouTube video, and you can watch the Masta Ace, Wordsworth, Stricklin and Marco Polo LIVE Q+A on the youtube player below.
Category: Exclusive


text: STORY INTRO: This is a story about Ashlynn my one year old niece having sex with me - an extreme sexually,graphic,erotic, and salacious fantasy story of pedo incest with an infant/toddler. Ashlynn My One Year Old Niece by LDZ Hello this is my sex story of me having sex with my adorable,beautiful,cute,darling,and gorgeous little niece with toehead color blond hair and her big skyblue color eyes with long eyelashes. She has a round little face with chubby cheeks. Her skin is very warm,soft,and smooth. She has beautiful little baby hands with beautiful little baby fingers on them. Her name is Ashlynn and she is only one years old. She has a lot of very good and sweet tasting baby saliva inside her beautiful baby mouth that is very warm.She has a beautiful baby pussy that is very warm,very wet,and very tight inside. Oh man her baby pussy juices are so sweet tasting and very warm. This is how this started: My sister called me and said that her and her husband had to go out town of due to an emergency and asked if I could babysit Ashlynn and I said sure. Little did I know that I was going to be in for quite a surprise sexually with my one year old niece. I think her daddy has been having sex with her because she sure knew how to do sex acts with men as I was going to find out and be pleasantly surprised. It was a very hot and muggy day that night that I was to sit for my one year old niece so I just had my shorts on wearing thongs and I am naked under my shorts I don't like to wear underware. when I showed up that night all my little niece was wearing was a diaper. My sister said they will most likely be gone for at least 3 days maybe more. All I could think of is wow 3 days or more of sexual heaven with my gorgeous one year old niece.Then my sis and bro in law said their goodbyes to little Ashlynn and I and were alone at last. I sat down on the couch the first thing my little niece did was jump up and sat on my stomach, then she was sticking out her warm and slobbery baby tongue like she was egging me on to stick out my tongue. Then I finally got the message to stick out my tongue too after her warm baby slobbery tongue landed on my mouth licking it. There was a lot of her sweet tasting warm baby spit on my lips and I licked her baby saliva off of my lips and it tasted so very sweet and yummy. When I stuck my tongue out my beautiful and gorgeous one year old niece didn't hesitate for a moment to put her warm and slobbery baby tongue on my tongue licking it that tasted so very sweet, we did that for a little bit and I could feel that my cock was starting to grow inside my shorts. Then my one year old niece was opening her baby mouth like she wanted to French kiss me. Sure enough as soon as I opened my mouth my beautiful and gorgeous one year old niece put her little baby mouth over my mouth and stuck her warm and slobbery baby tongue deep in my mouth and was French kissing me and while she was French kissing me she was totally slobbering in my mouth,all over my tongue, and down in my throat I was literally swallowing her warm and wet baby spit and it was a lot, and by now I was almost fully hard. We were literally exchanging saliva. We did that for a little bit,then when we were just about to stop that act and there was a long stem of saliva as we were just separating from each other's mouthes. Oh God her warm baby saliva tasted so very sweet and yummy. Ashlynn then procceded to take off her diaper and expose her beautiful baby twat to me that has chubby lips. After that she sat right on my face with the inside of her baby pussy over my mouth I knew what she wanted so I laid her down opening her beautiful baby pussy inserting my pointer finger inside her warm,wet, and tight hole and I was putting my finger inside, fingering her, and playing with her clitoris. She was moaning and groaning and to my surprise she was having orgasms. I didn't think baby and toddler girls had orgasms. Then I inserted my tongue inside her baby pussy,tongueing it,and tongueing her clitoris. Boy! The more I tongued the inside of her baby pussy the more she moaned and groaned - moving her legs,tightening them,making her body stiff,and having lots of orgasms.Oh man her baby pussy juices tasted so sweet and very yummy and the juices were very warm. I ate out my beautiful one year old niece's sweet baby pussy and her sweet baby juices just flowed into my mouth. I knew she's had sexual intercourse because when I inserted my finger inside her baby pus she had no hymen maybe they have a family orgies together. I'll have to find out and then maybe I can join them. When I finished eating my little one year old niece's cunny, I put a diaper back on her,put her on the floor to play with her toys,and then I sat on the couch watching TV. After a while I felt something warm,soft,and smooth on my cock tugging it,pulling it,squeezing it,and playing with it so I looked down and to my surprise my beautiful and gorgeous little one year old niece had her beautiful little baby hands inside my pants on my cock. Oh god that felt so good on my cock and of course I was getting an erection at the site of this, then I started watching the television again as my niece was doing this to my dick, then I felt a warm and wet sensation on my prick. So I looked down again and somehow one year old Ashlynn had my penis out of my pants through the opening were my legs are. I couldn't believe what I was seeing! There was my beautiful and gorgeous one year old little niece licking my cock all over with her warm and slobbery baby tongue while she was licking it all over she would be slobbering all over it with her warm and sweet baby saliva and of course at the site of her doing this act I was fully erect now. I have 8 inches fully hard and my beautiful and gorgeous one year old little niece was licking and slobberying all over it. Then I said to myself the heck with it and I took off my shorts so now I am fully naked sitting on the couch with a full hard on in front of my one year old niece. I was closing my eyes and enjoying this sex act that my one year old niece is doing to my cock. Then I felt even more of a wet and warm sensation on my fully erect cock from the head down to about 3 inches down the shaft, so I had to look for there was my beautiful and gorgeous little one year old niece with my cock inside her warm and slobbery baby mouth - sucking on it hard and sucking on it hard like she was sucking on a bottle. She was moving her head up and down and while she was sucking on my cock she was literally totally slobbering all over my cock, and in fact my balls were getting all soaking wet from her slobbering all over my cock so much with her very warm and sweet baby saliva, my whole rock hard cock was totally glistening and gleaming with her warm and wet baby spit. By now I was in total ecstasy. I was fucking the inside of her mouth and then I shot a big load in her sweet baby mouth and come to think of it, it was the biggest load I ever shot this far and she swallowed it and loved the taste of her uncle's hot fertile cum. My beautiful and gorgeous little one year old niece loved sucking my cock so much that she tried put it deeper inside her warm and slobbery baby mouth that it was in her throat and was gagging, then when she took it out of her mouth there was a very long stream of her sweet baby spit going from my cock to the inside of her baby mouth. She loved the taste of my cum so much that she was licking it off of my cock as it leaked out it just seems she just couldn't get enough of my cum. The next night my beautiful,cute,and gorgeous little one year old niece, was playing with,squeezing,and holding my cock again with her warm,soft,and smooth little beautiful baby hands untill it was hard again, so she took off her diaper and sat right on my rock hard cock and it was going inside her very warm, very wet, and very tight sweet baby pussy. She was moving up and down fucking my cock and riding it,it went in about 3 inches. We were both moaning and groaning really loud, she was having a lot of orgasms getting my cock really totally all wet with her warm and sweet baby pussy juices. she loved fucking me so much that she was literally trying put my 8 inch cock deeper inside her baby pussy but it wouldn't go I think she got maybe as much as 4 inches of it inside. We were both in total ecstasy now so then I shot a hell of a load deep inside her baby womb and this was literally the biggest load that I've ever shot off . OH MY GOD DID IT EVER FEEL SO GOOD WHEN MY BEAUTIFUL,CUTE AND GORGEOUS LITTLE ONE YEAR OLD NIECE LICK MY ROCK HARD COCK ALL OVER WITH HER VERY WARM AND VERY SLOBBERY SWEET BABY TONGUE. OH MY GOD DID IT EVER FEEL SO GOOD WHEN MY BEAUTIFUL,CUTE AND GORGEOUS LITTLE ONE YEAR OLD NIECE SUCK MY ROCK HARD COCK WITH HER VERY WARM AND VERY SLOBBERY SWEET BABY MOUTH. OH MY GOD DID IT EVER FEEL SO GOOD WHEN MY BEAUTIFUL,CUTE AND GORGEOUS LITTLE ONE YEAR OLD NIECE FUCK MY ROCK HARD COCK WITH HER VERY WARM,VERY WET, AND VERY TIGHT SWEET BABY PUSSY. END OF STORY... The End


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Danner 42980
Danner Striker™ II GTX® Uniform Boots
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You go where others won't and you do what others can't. No wonder your boots have to be tough and flexible. The Striker II GTX's lightweight-yet-sturdy construction delivers.• Full-grain leather upper can be easily polished
• 100% waterproof and breathable GORE-TEX® liner is engineered to keep your feet dry and comfortable
• 1000 Denier nylon upper material is extremely resistant to abrasions, tears, and scuffs, improves breathability, and dries quickly
• TERRA FORCE™ X Lite platform provides lightweight, durable traction, heel-to-toe energy transfer, side support to enhance maneuverability, and protection from arch overwork and fatigue
• Danner TFX® Lite outsole is an oil- and slip-resistant outsole
• Nylon shank
• 8" height
• 48 oz
• Imported
• Imported
|Customers who viewed the Danner 42980 also viewed:
Wolverine W06654
Hudson Mid-Cut Steel-Toe Electrical Hazard Slip Resistant Hiker
Wolverine W04326
Tremor DuraShocks® Work Boot - 6"
Bates E00056
Lites® Oxford
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Asthma worsens in winter months
Asthma is the No. 1 reason children are admitted to Children's Hospital of Wisconsin, and winter in Wisconsin is a time when asthma sufferers have to be especially careful to prevent asthma attacks. Cold air can trigger asthma flare-ups. Winter also can bring an increase in sinus infections and upper respiratory viral infections that trigger or worsen asthma.
Consider these tips to help prevent winter asthma attacks:
- Dress warmly. Cover your nose and mouth with a scarf when outside. This helps to warm and moisten the air before it is breathed into the lungs.
- Monitor air quality indoors. Avoid using wood stoves or fireplaces because they pollute the air.
- Keep your body healthy. Get your annual flu shot and wash hands frequently. Be proactive in avoiding illness. Colds and other respiratory infections can lead to asthma flare-ups.
- Be cautious of over-the-counter cold medications that may trigger a bad reaction or upset the success of your current asthma treatment program.
- Always make sure you and/or your child have your medication before going outside.
Your physician is your best source for information if you have questions. Follow your physician's plan for ongoing asthma care and management. Notify your doctor immediately if you or your child becomes sick during the season. Regardless of any precautions you take, make sure you are ready to handle an asthma episode before it occurs.
~ Michael C. Zacharisen, MD, allergist and immunologist at the Asthma, Allergy and Clinical Immunology Center at Children's Hospital of Wisconsin.


text:
Delayed and Deprecated Features in Entity Framework Core
While Entity Framework has a rather ignominious reputation for breaking backwards compatibility, it pales in comparison to the total rewrite undertaken for Entity Framework core. In this article InfoQ looks at some of the major feature changes and their repercussions.
Rebooting Entity Framework
Entity Framework is being rebooted with an initiative called "Entity Framework Everywhere". The goal of this project is dramatically reduce both the complexity of Entity Framework and the resources needed to run applications that use it. This will in turn allow it to run on a wider variety of platforms including Windows Store and Windows Phone.
ASP.NET Identity 2 Adds Two-factor Authentication, Account Lockout, Security Stamp and Bug Fixes
ASP.NET Identity 2 RTM, recently released by Microsoft provides support for Two-factor authentication, account lockout, security stamp besides several improvements and bug fixes.
EF Gets Public Mapping API, Ability To Handle Commit Failures
Entity Framework 6.1 was recently released with several interesting improvements such as better tooling, CommitFailureHandler, IndexAttribute, a Public Mapping API and more.
DynamicData and EntityDataSource Updated with Entity Framework 6 Support
Microsoft recently added Entity Framework 6 support for DynamicData and EntityDataSource controls with in addition to refreshed the templates. It also has few known issues as the support is limited to C# and Web Application projects.
RadControls for WPF and Silverlight Q2 2013 SP1 with Entity Framework 6 Support and Several Features
Telerik has released RadControls for WPF and Silverlight Q2 2013 SP1 with the ability to change application icon set during runtime in addition to support for Entity Framework 6. It also provides an ability to pass event arguments to command when using Telerik EventToCommandBehavior in addition to several new features and improvements.
Leveraging DDD in Core-Business Applications Using Entity Framework
Domain-Driven Design, DDD, is all about the domain, not about persistence. With a history of database programming for 25 years, later years using Entity Framework, Julie Lerman, a consultant on the .NET platform and a Microsoft MVP, in a recent presentation at the Øredev developer conference shares her persistence experiences when moving into DDD.
Slow Startup Time and Entity Materialization Issues Affects Entity Framework 6
Developers reported decrease in startup time and slow entity materialization while working with Entity Framework 6. However, the product team was quick to react with a patch which fixed one issue while Microsoft is working hard to fix other bugs and a new patch release will be available in the near future.
Experiences Going From Data-Driven Development to Domain-Driven Design
With a long history of data-driven development, Julie Lerman shares her experiences moving into using her skills with Domain-Driven Design in three articles, with examples in C# using Entity Framework
Entity Framework Power Tools Beta 4 Adds EF 6 and Visual Studio 2013 Support
Microsoft has released Entity Framework Power Tools Beta 4 with support for Entity Framework 6 and Visual Studio 2013.
ORM Profiler v1.5 with Entity Framework 6 and Async Support
ORM Profiler v1.5 has been released with support for Entity Framework 6 and Async in addition to several improvements and bug fixes.
WCF Data Services 5.6.0 Adds Entity Framework 6 Support
The recently released WCF Data Services 5.6.0 provides support for Entity Framework 6 and provides an option either to upgrade or create nww OData services to target EF 6.
ORMs And Persistence Ignorance
Julie Lerman recently noted that Entity Framework can work with classes having private constructors and private property setters, which promotes persistence ignorance. We explore further.
Entity Framework 6 RC Adds SQL Logging, Testability Improvements and New IntelliSense Documentation
Microsoft has released release candidate version of Entity Framework 6 with support for interception, SQL logging, testability improvements. It also includes substantial changes to API, IntelliSense documentation.
ASP.NET and Web Tools for VS 2013 Preview with One ASP.NET, New HTML Editor, MVC5, SignalR 2, EF 6
The recently released ASP.NET and Web Tools for Visual Studio 2013 includes new HTML editor for Razor and web project files, ability to build all type of ASP.NET applications from a single dialog, claims based authentication in addition to support for SignalR 2.00 Beta1 and Entity Framework 6.0.0 beta1.


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Blogs // 1 Articles
3 Inches of Blood - Here Waits Thy Doom
3 Dec 2009 // 4:00 PM
The Canadian headbangers continue to prove that there's life after "Deadly Sinners".
3 Inches of Blood: Fire Up the Blades
9 Jul 2007 // 6:00 PM
If you're searching for 2007's essential retro-metal fix, look no further.
Blood and Thunder: Battles, Blades, Brotherhood
4 Jun 2015 // 4:23 AM
One of Canada's greatest metal bands of the past 25 years, 3 Inches of Blood, recently bid farewell over Facebook. Fortunately, the legacy they've left is a fine one.


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Linking University and High School Students: Exploring the Academic Value of Service Learning
While universities and colleges aim to become more inclusive and welcoming to students from a variety of backgrounds, major gaps remain in relation to particular high school students being admitted to postsecondary institutions. Located in Toronto, Canada's most culturally diverse city, Ryerson University has a commitment to both academic and applied learning. Recently, Ryerson initiated an experiential learning program (ELP) to connect with high school from these diverse groups.
This case study will focus on one ELP, a service learning project involving university students enrolled in a fourth year Education and Politics class and a downtown Toronto Grade 12 class. This Toronto high school has consistently scored in the lower one-third in board-administered standardized tests. By bringing together these high school and university students in a variety of different activities over one semester, this case study aims to examine the types of learning that occur outside of a traditional university setting. In addition, attention will be focused on the varied approaches to learning for high school students that result from their interactions with university students, and the knowledge these university students will accumulate regarding social, economic, and systemic barriers that prevent some high school students from seeking further educational opportunities.
Service learning can offer critical and insightful considerations of equity and community engagement issues that relate to this case study. This session will also focus on the theoretical literature related to service learning to situate this particular study more specifically. By building linkages, service learning has the potential to help educators better understand and contribute to learning within communities of high school and university students.
Keywords: Service Learning, Urban Education, High School Students, University Students
Dr. Duncan MacLellan
Assistant Professor, Department of Politics and Public Administration, Ryerson University
Ref: L09P1014


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It never ceases to amaze me when God shows me something so clear. When I left Alley, I was depressed and bitter. I maybe left him for a little longer than I should have, but the Lord did not let me run away from Him. He yelled and YELLED at me until I turned my life down enough to listen.
Ok, now about this amazing thing. I was upset one day because I have a hard time forgiving myself for the things I did. Anyway, for some reason we were reading Isaiah in church, and I decided to read on my own for some reason. I was praying through communion about getting help to forgive myself, and here is what I got:
For your Maker is your husband— the LORD Almighty is his name— the Holy One of Israel is your Redeemer; he is called the God of all the earth.
6 The LORD will call you back as if you were a wife deserted and distressed in spirit— a wife who married young, only to be rejected," says your God.
7 "For a brief moment I abandoned you, but with deep compassion I will bring you back.
8 In a surge of anger I hid my face from you for a moment, but with everlasting kindness I will have compassion on you," says the LORD your Redeemer.
9 "To me this is like the days of Noah, when I swore that the waters of Noah would never again cover the earth. So now I have sworn not to be angry with you, never to rebuke you again.
10 Though the mountains be shaken and the hills be removed, yet my unfailing love for you will not be shaken nor my covenant of peace be removed," says the LORD, who has compassion on you.
Ok, so not exactly talking about a person here, however, it was just what I needed to hear at that point in time. It was a verse in Isaiah ALSO about Zion that I received when I was praying about going back to Alley. Anyway, I just love when I get answered prayers that I can HEAR.
Whether that made sense to anyone but me, I don't know, nor care. I just wanted to document it somewhere so I wouldn't forget...and maybe my words are meant for someone else to see. There is no such thing as coincidence nor "accidents." God divinely orchestrates EVERYTHING, whether you want to believe it or not.


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try the following:
Also you need to edit your interface into wifizoo.py - line 48Code:python wifizoo.py -i ath0
I'm on a 64 bit wep encrypted network so i usually setup a virtual interface using airtun-ng (at0) this interface decrpyts the packets on the fly quite well and seems to work with ettercap pretty well but for some reason dosent seem to be working for wifizoo even tho i specify
am i missing something here???Code:python wifizoo -i at0
try the following:
Also you need to edit your interface into wifizoo.py - line 48Code:python wifizoo.py -i ath0
The pure and simple truth is rarely pure and never simple.
He is trying to decrypt the traffic with a tool called airtun-ng which creates a tap interface "at0" and decrypts the traffic via the tap interface at0.
I think the problem is that airtun-ng does not retain the 802.11 headers which wifizoo requires.
please post the logoutput after starting wifizoo.
did you bring your at0 inferface up?
Zermelo is right. I tried the same thing, using airtun-ng and the virtual interface at0 to bring some datas to wifizoo, and I had the same issue. I finally understood that wifizoo only works with paquets captured via a wifi device, and not with an ethernet device, since it only supports frames with ieee 802.11 headers.
I found one tricky solution to this, I use airodump-ng to capture the datas, then I use airdecap-ng with the -l option, so that it doesn't remove the 802.11 headers, and then I open the decypted .cap file with wifizoo, and it works. The problem is that it doesn't permit to get the informations in live. If someone have an idea to use airtun-ng and modify the headers in live from the virtual at0 interface so that the datas can be used with wifizoo, please let us know...
--~ Internet is in the air we are breathing, so it should be free for everyone. We'll get there, just wait and see... ~--
yeah i am aware of using captured files but this not really as exciting as having real time traffic to analyse anyways i am still searching for an answer to this on google in case u guys come across some thing please do post
better, provide key to airtun-ng .... sniff at0 the tunnelled iface created with wifizoo.....and get real time decrypted traffic
it works for sure ...; i have even use that to add wep support in an unofficial version of wz (formerly know as 1.4 but not available for public )
Watch your back, your packetz will belong to me soon... xD
BackTrack : Giving Machine Guns to Monkeys since 2006
What more is there? Wifizoo will just sit there with no output.Code:airtun-ng -a 00:11:22:33:44:55 -w 1122334455 wlan0 ifconfig at0 up python wifizoo.py -i at0


text:
Before Escobar and his posse would surrender, the drug kingpin had a few stipulations.
He once told me he got the idea for his posse from all the Western movies he watched as a child.
There's a reason that we have police departments and not posse's roaming around bringing "justice" to people.
To do this, Mike said they have to "posse up, get into this gang mentality."
So [after becoming sheriff] I said, 'Wait a minute, I'm going to build up my posse.
This cook, Steck, was captured by the posse behind the breastworks.
Illness had not been accepted by the "posse" as an excuse for delay.
I'll be out here bright and early tomorrow morning with my posse, an' we'll take them fellers off'm your hands.
He was said to have been with the posse that killed Tunstall.
And where he ate the sheriff and his posse would likewise have to dine.
1640s (in Anglo-Latin from early 14c.), shortening of posse comitatus "the force of the county" (1620s, in Anglo-Latin from late 13c.), from Medieval Latin posse "body of men, power," from Latin posse "have power, be able" (see potent) + comitatus "of the county," genitive of Late Latin word for "court palace" (see comitatus). Modern slang meaning "small gang" is probably from Western movies.
: I thought posses were Jamaican. Language changes very fast here, now it just means a small gang
[1980s+ Black teenagers; probably fr the sheriff's posse seen so often in cowboy movies]


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[Software] ISTC-CNR, and noze, and Gianguglielmo, C. and Giovanni, P.
Akira. [Other]
The ambitious goal of AKIRA is to create a development tool allowing to build virtual worlds and to populate them with agents manifesting high-level behaviour. The advanced underlying logic represents a general framework that allows to integrate all the relevant aspects of the interaction betweens agents and their world. Thanks to AKIRA it is possible to model Agents, with different intelligence degrees and computational requests, that are able to act in an external world interacting with the AKIRA's server through the AKIRA's XML Transmission Protocol.
This is a Test review
Archive Staff Only: edit this record


text:
Vienna (Jul. 12)
Representatives of Vladimir Jabotinsky, leader of the Zionist Revisionist Party, arrived here today for the purpose of negotiating with the Austrian authorities to permit the holding in Vienna of the first world congress of the newly proclaimed Independent Zionist Organization.
It is understood that the Austrian authorities are considering the Jabotinsky proposal sympathetically The Revisionists have selected Vienna as the potential site of their first congress since it is the city where Dr. Theodor Herzl, founder of the political Zionist movement, is buried. Praha, capital of Czechoslovakia, has also been considered.
The congress will be held in September. It will open a few days after the Nineteenth World Zionist Congress adjourns in Lucerne.


text:
Jefferies has hired Christie Ju as the head of Hong Kong and China equity research. She will manage its equity research practice there and cover the property and real estate and conglomerates sectors. Ms Ju is based in Hong Kong. Jefferies is establishing a full-service equity sales, trading and research capability focused on Asia, including Hong Kong, Japan, Singapore, Korea and Taiwan.Staff reporter
Return Fund reported a 0.04 per cent monthly return and 13.3 per cent for the financial year to date.Staff reporter
Staff reporter
The Australian Financial Review


text:
Inspections, Compliance, Enforcement, and Criminal Investigations
Seafarers Inc. 24-May-05
Department of Health and Human Services
Public Health Service
555 Winderley PL., Ste. 200
May 24, 2005
Guillermo A . Rosell, President
Seafarers Inc.
5900 NW 97th Avenue, Suite No. 18
Miami, Florida 33178
Dear Mr. Rosell:
On February 9, 2005, the Food and Drug Administration (FDA) conducted an inspection of your seafood importing facility located at 5900 NW 97th Avenue, Bay #18, Miami, Florida 33178. 'The inspection was conducted to determine your firm's compliance with FDA's seafood Hazard Analysis and Critical Control Point (HACCP) regulations (21 CFR Part 123).
During our inspection, we observed a serious deviation from the principle of HACCP and the significant requirements of the program. Our investigators provided you with the Inspectional Observations (form FDA 483), which presents their evaluation of your firm's performance regarding various aspects of the HACCP requirements. The observation of concern to us is as follows:
1. You must implement an affirmative step which ensures that the fish and fishery products you import are processed in accordance with the seafood HACCP regulation, to comply with 21 CFR 123.12(a)(2)(ii). However, no affirmative step was performed for fresh tuna imported from [redacted]. This observation is similar to an observation from our March 12-18, 2002 inspection of your facility, where we noted that there were no records available to indicate that fresh tuna that you received from another foreign processor had been processed under conditions that comply with the seafood HACCP regulations.
We acknowledge receipt of your written response dated March 2, 2005 and accompanying documentation. However, we find your response fails to provide proper corrective action in that the [redacted] HACCP plan provided lists inadequate critical limits and monitoring procedures at "Receiving" or a primary processor of fresh histamine forming fish. The HACCP plan also fails to include a storage critical control point as designated in the primary processor's hazard analysis.
We also note that your written verification procedures list multiple affirmative steps that your firm may choose to implement. These steps include maintaining the HACCP plan and written guarantee of the foreign "supplier." However, an appropriate affirmative step requires maintaining the HACCP plan, in English, and a written guarantee from the foreign processor, in order to comply with 21 CFR 123.12 (a)(2)(ii)(D). We suggest that you revise your written procedures.
The above identified deviation is not intended to be an all inclusive list of deficiencies at your facility . It is your responsibility to ensure that all seafood products processed and distributed by your firm are in compliance with the Act and applicable regulations. You should take prompt measures to correct these deviations. Failure to promptly correct the deviations noted may result in regulatory action without further notice. Such action includes seizure and/or injunction. In addition, FDA may take steps to refuse your imported seafood products, including placing them on detention without physical examination, until the violation is corrected. Under such conditions, FDA will not issue any Certificates to Foreign Governments for any of the affected fish and fishery products processed at your facility.
Please notify this office in writing within fifteen (15) working days of receipt of this letter of the specific steps you have taken to correct these violations, including an explanation of each step take to prevent their reoccurrence. Your response should include copies of any available documentation demonstrating that corrections have been made. If corrections cannot be completed with 15 working days, state the reason for the delay and the time frame within which the corrections will be completed.
Your reply relating to these concerns should be directed to the Food and Drug Administration, Attention: Shari H. Shambaugh, Compliance Officer, 555 Winderley Place, Suite 200, Maitland, Florida 32751 . If you have questions regarding the implementation of the HACCP Regulations, please contact Ms . Shambaugh at (407) 475-4730 for answers and/or direction towards guidance and sources of training in achieving compliance.
We look forward to working with you to achieve a successful HACCP program.
Emma R. Singleton
Director, Florida District


text:
means first class, postage prepaid.
Rule 9001. General Definitions
margin payment
means, for purposes of the forward contract provisions of this title, payment or deposit of cash, a security or other property, that is commonly known in the forward contract trade as original margin, initial margin, maintenance margin, or variation margin, including mark-to-market payments, or variation payments; and [2]
Sec. 101. Definitions
margin payment
means payment or deposit of cash, a security, or other property, that is commonly known to the securities trade as original margin, initial margin, maintenance margin, or variation margin, or as a mark-to-market payment, or that secures an obligation of a participant in a securities clearing agency.
Sec. 741. Definitions for this subchapter
The doctrine of marshalling> <is an equitable remedy which the bankruptcy court may apply in its discretion. In Oregon, it has been defined as a "basic principle of equity that where a senior creditor has recourse to two funds and a junior creditor has recourse to but one of them, the senior creditor must seek to satisfy itself first out of the fund in which the junior creditor has no interest." Community Bank v. Jones, 278 Or. 647, 678, 566 P.2d 470, 488 (1977)
In order to support a claim for marshalling of assets, the creditor must prove "(1) the existence of two creditors with a common debtor; (2) the existence of two funds belonging to the debtor; (3) the legal right of one creditor to satisfy his demand from either or both of the funds, while the other may resort to only one fund." Id. at 14-15; See also Exchange Bank of Kingstree v. South Carolina Nat'l Bank (In re Dig It, Inc.), 129 B.R. 65 (Bankr.D.S.C. 1991).
mask work
has the meaning given it in section 901(a)(2) of title 17.
Sec. 101. Definitions
A list of the names and addresses of creditors typically filed with the petition and schedules upon commencement of the bankruptcy case.
may not
is prohibitive, and not permissive.
Sec. 102. Rules of construction
meeting of creditors
A meeting that takes place about 30 days after the commencement of a bankruptcy case. The debtor (s) must attend this meeting, at which creditors may appear and ask questions regarding the debtor's financial affairs and property. 11 U.S.C. § 343. If a husband and wife have filed a joint petition, they both must attend the creditors' meeting. The trustee also will attend this meeting. It is important for the debtor to cooperate with the trustee and to provide any financial records or documents that the trustee requests. The trustee is required to examine the debtor orally at the meeting of creditors to ensure that the debtor is aware of the potential consequences of seeking a discharge in bankruptcy, including the effect on credit history, the ability to file a petition under a different chapter, the effect of receiving a discharge, and the effect of reaffirming a debt. This meeting is also sometimes called the "341" hearing, named after the section of the Bankruptcy Code authorizing it.
Public Information Series of the Bankruptcy Judges Division
a request filed with the bankruptcy clerk setting a court hearing and seeking an order of some kind from the judge
means political subdivision or public agency or instrumentality of a State.
Sec. 101. Definitions


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My older son just turned 13 and it seems that punishments that had more of an impact before are no longer working. His grandparents gave him a cell phone (that's a whole other issue) so I thought about doing some sort of contract that would state if he gets in trouble he gets it taken away for X amount of time.
Any other ideas?


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Photos from 2011 Dublin MarathonMonday, October 31st, 2011
Instead of running this year's Dublin Marathon, I headed out and took photos of some of the participants in the city's biggest race of the year. Most of the shots were taken during the heavy downpour on Nutley Lane.
Click on the pics for full sized images.
For our full collection of 33 photos from the Dublin [...]


text:
Lucy freaked out. The rope was tied securely around the base of the fan, and her hands were failing about. When she was running out of air, she started to gasp. Trying to inhale some kind of air.
Oxygen. Then she remembered that this was the way she chose to end it. So she just fell limp, and her vision started to blur. Then, everything went black.
Among the muddiness in her brain, Lucy heard a shout.
Keith had thrown open the door, and was racing through the house to find her.
"Lucy!" He shouted. He paused just a millisecond to listen to the thrashing coming from one of the rooms upstairs. He was fighting for air, but he still leapt up the stairs and burst into her room.
There she was, hanging from the ceiling, limp. Keith thought he was too late. His heart stopped and then he sprang into action. "Lucy, no!" The chair had fallen over in Lucy's little panic attack, and it was the same chair that Keith picked up to untie the rope around her neck.
Finally, the knot came free, and Lucy toppled to the ground. She still wasn't breathing. Keith faintly heard sirens outside, and jumped down from the chair to her side. Her neck was purple and blue and her eyes closed. Tears were falling down Keith's cheeks but he wiped them away hastily.
He picked her up in his arms and ran down the stairs and outside. Police and firemen were scattered all around and people from the neighborhood and school were there. Just standing there, watching. "Someone help me!" Keith yelled. Many firemen turned around and then seeing lifeless Lucy in Keith's arms, hurried over to help. "How long?" One of them asked. He didn't have time to check his watch, so he guessed. "At least maybe 5 to 10 minutes." Keith felt the weight of Lucy being lifted from his arms, but he couldn't see due to the tears that were blinding him. He used his now free hands to viciously whisk them away, and ran with the firemen who were fighting their way to an ambulance. They put Lucy down on a gurney.
"You're gonna have to back away kid." One of the firemen said to Keith. "No! I'm the one who rescued her. I'm not going to leave her." The firemen gave him a look and opened his mouth but he cut him off, "I'm not going anywhere." The firemen just let him be, and Keith turned his attention back to Lucy.
Her skin was starting to get pale. When he pointed this out to a firemen, he hurried her into the ambulance. Keith climbed right in after them. No one said anything to him. He held Lucy's hand all the way to the hospital.
They threw open the doors and hurried the gurney onto the cold pavement. Inside they raced down hallways to a large operating room. Keith held Lucy's hand all the way. "You're gonna be okay Lucy. I know you will." He whispered to her.
Then a nurse turned to him when they were wheeling Lucy into a room. "This is the furthest I can allow you." She saw the look on Keith's face, and was instantly saddened. She felt so bad for him. "You'll have to sit over there. I'll let you know how she is as soon as I can." And with that, she walked in the room, leaving Keith to cry in peace.
He sat in the waiting room for Lucy's specific room. He put his elbows on his knees and leaned his head into his hands. But all he saw was image of Lucy dangling from the ceiling. Then Keith put his head between his legs. He felt like throwing up. He didn't want to remember her like that. Lifeless.
About a few hours later, Keith realized that he was surrounded by people. Grace had a hand on his shoulder and Megan was hugging him. Riley and Amber were sitting on either sides on them, crying their eyes out. Faith and Bruce were sitting across from them and holding onto each other both of them crying.
When Keith started returning Megan's embrace, Grace shifted over to Amber to comfort her. Even though Grace had tears in her own eyes, she was trying to make everyone else feel better.
Keith was oblivious to everything. The only thing his eyes would focus on was the door which Lucy was behind.
Bruce eventually pulled himself together and tried to take charge of the situation. "Are you kids hungry?" He meant to say, but what came out was: "Hungry?" His voice wouldn't cooperate very well. Everyone shook their heads and then he went back to mourning with his wife.
It seemed like hours until the nurse came back out. Keith stood up so fast that it startled Megan. He was standing in front of her before she had even said a word. "Is she alright? How is she? Did she make it?" Keith threw questions at her. The nurse patted his arm, and addressed him and the room of people behind them.
"She's gonna be alright." All the tension in the room went flying away, and everyone broke into fresh tears. Except these were tears of joy.
"This young man here go to her just in time. Nothing was permanently damaged. She probably won't be able to talk for a few hours, maybe more. But other than that, Lucy will be fine." The nurse looked pointedly at Keith. "She's gonna be fine. You saved her." That was his final breaking point. His shoulders sagged and he started to cry. The nurse's heart ached for him, and she held him while his shoulders heaved from crying so hard.
Keith stood up straight, done with temporary breakdown. "When can we see her?" The nurse smiled, "Now if you would like but you'll have to be quiet. She's awake, but she's tired." He nodded, and looked to Faith.
Faith smiled with tears in her eyes. "You saved her Keith. You go first." All he could do was nod.
When he stepped into the room, he smelled disinfectant and heard a bunch of beeping. There were tubes going in and out of Lucy, yet other than the bruise on her neck, she still looked like Lucy. Keith smiled at her. And walked carefully to her side. Tears slid out of her eyes, "Keith?" He hushed her, and she started to cry more. He just held her hand, and waited until her tears were over. "Everything's fine Lucy. You're fine. In fact, you're not even supposed to be talking yet."
Even under the circumstances, Lucy blushed. "Well I guess I'm better than they thought." Keith chuckled. It was nice to hear her voice again.
He leaned down, and kissed the top of Lucy's head. "I should let everyone else have a chance with you. Everyone came to see if you were OK." Lucy smiled, and Keith slowly let go of her hand. "Keith," He stopped walking. "Thank you." He shook his head.
"It was all worth it Lucy. Trust me."


text: Dr. Munirathnam Srikanth Founder & CTO, ComputeNext Introduction: I grew up in Chennai, India (formerly Madras). My fascination for math and science came from my grandfather who was a school teacher. I studied Mathematics and Computer Science at BITS, Pilani, India and started working in the IT sector. … [Read more...]


text:
NEW YORK (AP) — Police are questioning a second person about the dismembered remains of a woman found in garbage bags on New York City streets.
Police said Wednesday they continued questioning a 23-year-old man who was taken into custody earlier. They have said he made remarks implicating himself.
They're describing the second person as a "person of interest."
As yet, no one has been charged.
A man out walking his dog found the first bag when his pet sniffed it on a Bronx street early Tuesday. Police then found three other bags with remains on surrounding blocks.
Police believe the victim was 45-year-old home health aide Tanya Byrd.


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Northbound SA Amtrak Passengers Moved to Bus Due to Track Construction
Steel wheels are being replaced by rubber tires for passengers of Amtrak in and out of San Antonio to Dallas, St. Louis, and Chicago, Newsradio 1200 WOAI reports.
Amtrak's Marc Magliari says the trains will no longer rumble out of Sunset Station at 7AM on the first link of the Texas Eagle, due to major track construction.
"This is a major construction project just south of Ft. Worth, which in the end, will make it a lot easier for our trains to get into and out of Ft. Worth," Magliari told Newsradio 1200 WOAI.
But Magliari says passengers will still be transported by Amtrak from San Antonio to Dallas Ft. Worth.
"Our passengers will be carried on chartered busses which will represent the trains, which will travel between San Antonio and Ft. Worth for the next several weeks," he said.
Magliari says the bus trip will be booked by Amtrak and will be part of the fare. Passengers don't have to buy the bus ticket separately.
He says the bus will be considered part of the train trip, so the Amtrak trains which will leave Dallas Ft. Worth bound for points north on the Texas Eagle will wait for bus passengers who board in San Antonio and Austin.
"We'll be transporting people by these chartered busses," he said. "The busses probably won't make as good a time as the train does, because as we know, I-35 can be kind of congested between there and there."
The bus link will only affect passengers on the Texas Eagle, which runs daily from Chicago to San Antonio, and will only carry passengers between Dallas Ft. Worth and San Antonio. The rest of the Texas Eagle, and the Sunset Limited from San Antonio to Los Angeles, will continue to run on standard Amtrak trains.
The trains will resume making the full trip to San Antonio on September 3.


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Do warnings deter rather than produce more sophisticated malingering?
Schenk, Kathryn & Sullivan, Karen A. (2010) Do warnings deter rather than produce more sophisticated malingering? Neuropsychology, Development and Cognition. Section A : Journal of Clinical and Experimental Neuropsychology, 32(7), 752-762 .
Following Youngjohn, Lees-Haley, and Binder's (1999) comment on Johnson and Lesniak-Karpiak's (1997) study that warnings lead to more subtle malingering, researchers have sought to better understand warning effects. However, such studies have been largely atheoretical and may have confounded warning and coaching. This study examined the effect on malingering of a warning that was based on criminological-sociological concepts derived from the rational choice model of deterrence theory. A total of 78 participants were randomly assigned to a control group, an unwarned simulator group, or one of two warned simulator groups. The warning groups comprised low- and high-level conditions depending on warning intensity. Simulator participants received no coaching about how to fake tests. Outcome variables were scores derived from the Test of Memory Malingering and Wechsler Memory Scale-III. When the rate of malingering was compared across the four groups, a high-level warning effect was found such that warned participants were significantly less likely to exaggerate than unwarned simulators. In an exploratory follow-up analysis, the warned groups were divided into those who reported malingering and those who did not report malingering, and the performance of these groups was compared to that of unwarned simulators and controls. Using this approach, results showed that participants who were deterred from malingering by warning performed no worse than controls. However, on a small number of tests, self-reported malingerers in the low-level warning group appeared less impaired than unwarned simulators. This pattern was not observed in the high-level warning condition. Although cautious interpretation of findings is necessitated by the exploratory nature of some analyses, overall results suggest that using a carefully designed warning may be useful for reducing the rate of malingering. The combination of some noteworthy effect sizes, despite low power and the small size of some groups, suggests that further investigation of the effects of warnings needs to continue to determine their effect more fully.
Impact and interest:
Citation counts are sourced monthly from Scopus and Web of Science® citation databases.
These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.
Citations counts from the Google Scholar™ indexing service can be viewed at the linked Google Scholar™ search.
|ID Code:
|Item Type:
|Journal Article
|Additional URLs:
|Neuropsychology, Malingering, Simulation, Warnings, Deterrence theory, Test of Memory Malingering, Wechsler Memory Scale-III
|Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > NEUROSCIENCES (110900)
Australian and New Zealand Standard Research Classification > PSYCHOLOGY AND COGNITIVE SCIENCES (170000) > PSYCHOLOGY (170100)
Australian and New Zealand Standard Research Classification > PSYCHOLOGY AND COGNITIVE SCIENCES (170000) > COGNITIVE SCIENCE (170200)
|Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
|Copyright Owner:
|© 2010 Psychology Press, an imprint of the Taylor & Francis Group, an Informa business
|Deposited On:
|05 Aug 2010 21:49
|Last Modified:
|11 Jul 2017 01:01
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July 22, 2010 - OGP - US Rotax Grand Nationals Report
The Ocala Gran Prix/Tony Kart race team was front and center in New Castle, Indiana as they worked hard all weekend long to help their drivers succeed. When the dust had settled, DD2 driver Cody Hodgson walked away with the national championship and will join Florida Winter Tour champion Nick Neri in Italy for the Rotax World Finals later this year. Ocala Gran Prix also had the opportunity to work with Kosmic driver Daniel Formal and the team gelled nicely in two days of action to garner a third place podium result and a spot on America's team.
With a testing weekend planned prior to the event, twelve Ocala Gran Prix drivers and the crew of more than ten travelled north to New Castle Motorsports Park to tame the mile long facility. With some quick times put down by all drivers, it looked as if the weekend would be another dominant one by the OGP crew.
"The weekend test went well and Wednesday's official event practice was great for most drivers," expressed OGP President Jorge Arellano. "Our junior drivers were well up to speed as both Ashley Rogero and Oliver Askew topped the time sheets on occasion. Jack West was also on his game as he was in the top five all week long and showed the speed to run with the front runners. Racing has its fair hand in luck and some of our drivers had some good luck, while others struggled with the bad luck."
Disaster struck for 14-year-old Nick Neri in Wednesday morning's opening practice as a freak accident would see the youngster break his arm as he looked to take control of the Rotax Senior class. Neri was sent to see the IZOD IndyCar Series doctor as he required immediate surgery that saw a plate and seven screws inserted into his arm. Now a cheerleader for the rest of the week, Neri was back at the track for the remainder of the event helping the younger team drivers with driving lines and race craft.
The surprise of the weekend for the Ocala Gran Prix squad would have to be female driver Ashley Rogero. After competing in Mini Max and Cadet all season, Rogero was battling with the junior big dogs and holding her own as the week went on. After topping one of the timed sessions on Wednesday, Rogero worked with the team and fought hard throughout Saturday's pre final and main event scoring a solid fourth place finish. Missing Team USA by one spot, Rogero was hoping for a top twenty result when the week had started and never expected to be battling for a podium finish.
Junior pilot Jack West overcame a bent chassis in one heat race and a main event starting spot outside the top twenty to come home sixth while AJ Myers overcame a DNF in heat one to score a solid top ten result in ninth. Miami's Pietro Fittipaldi was at the pointy end of the field throughout the week and raced wheel-to-wheel with Team USA's future additions. A bold late braking pass in the pre final would see contact with another competitor at the end of the long straightaway and Fittipaldi would see his chance to travel overseas go away as he slid off the racing surface. Starting the main event in 39th, Fittipaldi battled hard for a top twenty result.
The dominant driver in DD2 all weekend was Californian Cody Hodgson. After qualifying on the pole and taking the first and third heat race wins, Hodgson went on to be perfect on Saturday taking the checkered flag in the pre final and final. On his way to the national title, Hodgson also scored the fastest race lap and will look to improve on his third place result from last year's Rotax World Finals in Egypt.
Half way through the week, OGP picked up the driving skills of Floridian Daniel Formal. With Neri out of the lineup, OGP's Mike Maurini was assigned the task of making sure Formal would be part of America's team. After qualifying fifth and finishing second in all three heat races, Formal claimed the win in the pre final before taking the third and final podium spot in the main event.
Masters drivers Rob Maier and Jason Bell overcame incidents in the pre finals and moved forward in the main event. After starting from the tail of the field, both drivers showed their speed as Bell managed to move forward and score a solid top fifteen result while Maier would be just outside the top twenty.
Arellano added, "This was another tremendous event for OGP, New Castle Motorsports Park and the crew of the US Rotax Nationals. I have no complaints and am happy to be part of this program."
A complete list of team results are below:
Rotax Junior
Oliver Askew – 23rd
Pietro Fittipaldi – 18th
Andrew Evans – 30th
Ashley Rogero – 4th
AJ Myers – 9th
Jack West – 6th
Ethan Low – 21st
Rotax Senior
Nick Neri - DNS
Brandon Salyer – 29th
Daniel Formal – 3rd
Rotax Masters
Jason Bell – 15th
Rob Maier – 22nd
Rotax DD2
Cody Hodgson – 1st
Rotax DD2 Masters
Nick Weil – 5th
Ocala Gran Prix will be purchasing chassis and providing testing sessions for members of Team USA. Stay tuned for future releases and dates as Ocala Gran Prix looks to ensure Team USA's success at the Rotax World Finals.
Return to News


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Coast Guard launches search near Charleston marina after guard hears screams
From our News Partners at WCBD-TV:
The Coast Guard in Charleston launched a search early Tuesday morning after a guard heard screams near the Charleston City Marina.
According to the Coast Guard, they launched a boat shortly after the call came in around 2:45 a.m. to look in the water, and Charleston Police and Fire also sent boats.
A Coast Guard helicopter is also now involved.
It is unclear if anyone is in the water, but they are treating it as though there is, and crews are searching the Ashley River, and Wappoo Creek because of the current.
Photo Credit: Aceshot1 Shutterstock


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text:
Hi! My name is Anna. I was born 13th June 1989 and I live in Moscow, Russia. I like to listen music, to make photos and to draw. I'm always glad to find new friends.
Current Residence: Russia
Favourite genre of music: Folk, Celtic, New Age, pop-music
Favourite photographer: Lisa Jane
Favourite cartoon character: x-men, Smeshariki, Daria
Personal Quote: Everybody lies


text:
Arthritis & Rheumatism, Volume 62,
November 2010 Abstract Supplement
Abstracts of the American College of
Rheumatology/Association of Rheumatology Health Professionals
Annual Scientific Meeting
Atlanta, Georgia November 6-11, 2010.
TRA-8 (CS-1008), a Novel Anti-Arthritic Biologic Agent That Targets Macrophages with Low Toxicity.
Li1, Jun, Hsu2, Hui-Chen, Yang2, PingAr, Wu2, Qi, Mountz1, John D.
Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL
Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL
Macrophages contribute to joint inflammation and destruction in both the acute and chronic phases of rheumatoid arthritis (RA). However, biologic agents that can selectively eliminate pathogenic macrophages in RA have not been identified. Death receptor 5 (DR5) is a pro-apoptotic protein, which mediates apoptosis upon binding to a novel anti-human DR5 antibody, TRA-8 (humanized, CS-1008). We have found that macrophages isolated from both synovium and peripheral blood of RA patients express DR5 and are susceptible to TRA-8 mediated killing. The purpose of this study is to use a humanized DR5 transgenic mouse to evaluate the therapeutic efficacy of TRA-8 by eliminating pathogenic macrophages in a chicken collagen II (CII)-induced arthritis (CIA) model.
A chimeric human/mouse DR5 transgenic mouse was generated using a 3kb mouse promoter/Floxed STOP/humanized mouse DR5 construct in which the extracellular domain of mouse DR5 was replaced by the human counterpart. Macrophages specific expression of chimeric DR5 is achieved by crossing the DR5 mice with lysozyme M-Cre mice. Arthritis was induced by AdIL-17 at day -2 plus intradermal injection of CII in CFA/IFA on day 0 and day 30. TRA-8 (0.2 mg per mouse) was administrated I.V. every 37 days starting on day 0 (early treatment) or on day 30 (late treatment) until mice were sacrificed 3 months after the primary CII injection. Enumeration of macrophages before and after CII injection was determined by FACS analysis. In vivo joint macrophage activity was quantitated using an infrared cathespin B in vivo imaging analysis. Clinical scoring and histologic assessments were performed to evaluate the severity of arthritis.
There was a higher percentage of CD11b+ macrophages in the spleen of CII immunized mice (12.08%) compared to naïve mice (2.5%). Chimeric DR5 is highly expressed on CD11b+ macrophage. TRA-8 treatment resulted in 60% and 48% reduction of CD11bhigh activated macrophages isolated from the spleen for early and late TRA-8 treatment, respectively. For both early and late TRA-8 treatments, joint histopathology showed a significantly decreased severity of inflammatory cell infiltration, synovial hyperplasia, cartilage damage, and bone erosion. Immunohistochemistry staining further demonstrated a dramatically reduced Mac-3+ macrophages in the synovium after TRA-8 treatment. In vivo live imaging of joints revealed that there was a significantly decreased macrophage activation-induced cathepsin B activity in chimeric DR5 Tg mice that received TRA-8 treatment. The arthritis clinical scores were highly correlated with the abundance of macrophages in synovium and spleen. Neither systematic toxicities nor increased incidences of infections and malignancies were found in TRA-8 treated DR5 Tg mice.
This study demonstrated that TRA-8 (CS-1008) is a novel anti-arthritic biologic agent with high safety. Importantly, since the DR5 molecule is expressed on macrophages, our results suggest that TRA-8 can be developed into a novel therapy to either prevent the onset or suppress established arthritis via elimination of macrophages.
To cite this abstract, please use the following information:
Li, Jun, Hsu, Hui-Chen, Yang, PingAr, Wu, Qi, Mountz, John D.; TRA-8 (CS-1008), a Novel Anti-Arthritic Biologic Agent That Targets Macrophages with Low Toxicity. [abstract]. Arthritis Rheum 2010;62 Suppl 10 :1135
DOI: 10.1002/art.28902


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