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Our new BIM compatible objects for Jetfloor Insulated Ground Floor System are now available to download.
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After five years, Burns It Up has announced that the troupe has found a new home at Center Pointe Dance, 4825 E. Warner Road, Suite 11, in Ahwatukee Foothills.
In addition to Burns It Up being the resident theater company of Center Pointe Dance, founder Karen Burns will also be offering classes for ages 5 and up, including musical theater, character dance and acting. Each class provides opportunities for students to expand their natural talent as well as build self-esteem and build trust in their own ideas, imagination and creativity.
The Center Pointe Dance studios offer Burns It Up the ability to reach more kids, as well as professional dance floors and space large enough for the troupe to offer additional opportunities, including community theatrical productions. Burns It Up members also have a wide range of additional class choices, such as ballet, jazz, contemporary, tap, hip-hop and tumbling taught by dance professionals in the Valley.
Auditions for Burns It Up will be Saturday, Aug. 21, and require a prepared monologue, a short song emphasizing vocal strengths and brief choreography learned during the audition. Audition prep classes are offered from 5:30 to 7 p.m. Fridays, Aug. 6 and 13, and are highly recommended. Depending on the number of cast members chosen from the audition, one or two troupes will be formed and will have weekly rehearsals.
Burns It Up troupe(s) will have numerous performances throughout the year including benefits, community events and competition.
Anyone interested in the Burns It Up program can contact Burns at (480) 332-7914, firstname.lastname@example.com or visit www.burnsitup.com. Center Pointe Dance can provide more information at (480) 598-8428.

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Simon Deleonibus: CEA-LETI Silicon Technologies & Components
Simon Deleonibus
IEEE Fellow and Distinguished Lecturer, CEA Research Director
PhD, Applied Physics, Paris University
More Moore and More than Moore Meeting for 3D
December 2, 2011 | 2:00 pm | Elings Hall 1605
Nanoelectronics linear scaling appeals to new 3D integration schemes in order to continue Moore's law. Unique opportunities exist to increase the device's performance, system complexity and also to reduce power consumption of mobile handheld objects. New design and functional architecture will be possible by mixing logic and memory devices to save power consumption and introduce new applications by using neuromorphic or bio inspired approaches. Devices other than CMOS can be co-integrated with CMOS to interface the outside Multiphysics world (MEMS, sensors and actuators, RF devices, power devices,etc.) allowing new functionalities. 3D Wafer Level Packaging and System on a Wafer allow these new routes.
Simon Deleonibus received his MSc and PhD in Applied Physics from Paris University in 1979 and 1982, respectively. He joined LETI-CEA in 1986 as an expert in device engineering and process modules development for CMOS and Flash memories applications. Since joining LETI-CEA, he has managed the Ultimate CMOS project and was appointed Director of the Electronic Nanodevices Laboratory. Simon is currently the Chief Scientist (Directeur Scientifique) at CEA-LETI Silicon Technologies & Components. Simon has published over 550 papers and holds 32 patents, including the initial patent on contact plug principle. He has received numerous awards and honors, including being selected as an IEEE Fellow and IEEE Distinguished Lecturer and is the Research director at the French Alternative Energies and Atomic Energy Commission (CEA).


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George Strait's 28th album "Somewhere Down in Texas" topped the U.S. pop charts Wednesday, sold 245,000 copies in the week ended July 3
Counting down time, Country veteran George Strait has already produced numbers of album and his now "Somewhere Down in Texas" becoming the 28th of his career. Experienced a lot in working music album, his latest one successfully topped the U.S. pop charts Wednesday for its third consecutive, sold 245,000 copies in the week ended July 3. Right after Strait was hip-hop duo Ying Yang Twins, whose "U.S.A.: United States of Atlanta" sold for 201,500 copies.
Halted by Strait's attainment, Coldplay's "X&Y" slipped to number three with 140,000 discs sold and soon followed by "The Emancipation of Mimi" by Mariah Carey, which fell two places to No. 4 with 130,500 copies. The No. 5 spot reigned by Cassidy's "I'm a Hustla," which was sold 93,000 copies, while at No. 6 was Black Eyed Peas' "Monkey Business" with 90,000 copies. Foo Fighters' "In Your Honor" dropped four to No. 7 with 88,000 copies, while No. 8 to 10 in sequence were; Kelly Clarkson's "Breakaway," Gwen Stefani's "Love. Angel. Music. Baby.," and Toby Keith's "Honkytonk University."


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Bob Buckner
CULLOWHEE For Bob Buckner, after this year the word march will no longer simply be a command that the longtime director of athletic bands at Western Carolina University issues to the 300 members of the Pride of the Mountains Marching Band. March likely also will become the name of Buckner's new favorite month.
That's because over the span of two days in mid-March, Buckner will receive the highest award given in the field of music education and will be inducted into a national band hall of fame.
MENC: The National Association for Music Education announced in October it would present Buckner with its Lowell Mason Award during its national conference on March 10. As Buckner was making plans to travel to Washington, D.C., to pick up his award, designed to recognize significant contributions to music education, he learned he would be inducted into the Bands of America Hall of Fame, just two days after the MENC event.
Bob's fingerprints are all over Bands of America, said Scott McCormick, president and chief executive officer of Bands of America, the nation's largest performing arts organization for high school bands. His contributions to the organization span four different decades.
The Bands of America Hall of Fame recognizes individuals who have greatly impacted the BOA organization, the nation's band activity, and music education in general, McCormick said. Buckner and other members of the class of 2005 will be inducted during a ceremony Saturday, March 12, in Indianapolis as part of the National Concert Band Festival Honors Concert.
Buckner is in his 14th year as director of athletic bands at Western. Under his leadership, the university's marching band has grown from 82 members to more than 300 during the 2004 season. Western now boasts the biggest marching band in the Carolinas, with a membership larger than the bands at the University of North Carolina-Chapel Hill, N.C. State University and Clemson, said Matt Henley, assistant director of athletic bands.
The Pride of the Mountains Marching Band has performed twice as an exhibition band at the prestigious BOA Grand National Championships, a showcase for the nation's top high school marching bands. Western's own Tournament of Champions, an invitational competition that brings 25 of the East Coast's top high school marching bands to campus every year, attracts some 10,000 musicians and spectators.
The Pride of the Mountains Marching Band, often called the world's largest funk-rock band, performs a crowd-pleasing medley of up-tempo pop tunes, with electric guitars, singers and other musical elements not typically associated with marching bands.
The BOA's McCormick has praised Western's unit as the most innovative and exciting marching band in the Southeast, and has called Buckner a legendary force in the marching band world, a leading pioneer of the modern-day marching band style, and one of America's leading drill designers for five decades.
Before coming to Western, Buckner guided the Sylva-Webster (now Smoky Mountain ) High School marching band to the title of national champion in 1979, seven years after directing the school's band to a national title at the St. Petersburg Festival of States.
Buckner won Western's Paul A. Reid Distinguished Service Award for faculty, one of the university's highest service awards, in 2003.
He has served on the Bands of America advisory board for several terms, was instrumental in the development of Grand Nationals format, helped launch the National Concert Band Festival, and has been on the faculty of the BOA Summer Symposium since the early 1980s. Buckner has served as chairman of the Western North Carolina Bandmasters and secretary of the North Carolina Bandmasters Association, and as an adjudicator, drill designer, guest conductor and clinician throughout the United States, Canada and Europe. He has served on the staff of the Spirit of Atlanta Drum and Bugle Corps and, in 1993, was the drill designer for the DCI Division II National Champion Carolina Crown.
Buckner has written field shows for more than 20 years for the U.S. Marine Drum and Bugle Corps. He has also served as a special consultant to the Walt Disney Co., where he started its popular Future Corps program and served on the board of advisers for Magic Music Days.


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The nursing curriculum provides a background in principles of nursing, the biological, physical, and behavioral sciences, as well as liberal arts. This rigorous academic curriculum ensures that our graduates are well prepared to function as a beginning professional nurse.
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How Sir Galahad, Sir Bors and Sir Percival Were Fed with the Sanct Grael; but Sir Percival's Sister Died by the Way
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New Year Praize Party
Monday, December 31, 2012 at 7:00 PM - Tuesday, January 1, 2013 at 12:00 AM (EST)
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December 31 2012 @ 7pm-12am, Church Cross ONE Int'l present dj half oz and dj tony in the mix, gospel artist performers this New Years Eve located @ Church Cross ONE Int'l 699 Rountree Rd, Riverdale GA 30274 for more information call 770-994-7144 or email us firstname.lastname@example.com
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Wish I could join protests, says CJI
Chief Justice of India Altamas Kabir on Monday said he wanted to participate in the anti-gang rape protests in the Capital, but could not.delhi Updated: Jan 22, 2013 01:45 IST
Chief Justice of India Altamas Kabir on Monday said he wanted to participate in the anti-gang rape protests in the Capital, but could not.
"I wish I were there, but I could not," the CJI said while speaking to journalists after the 6th conference on the Protection of Women from Domestic Violence Act.
Justice Kabir said the outburst of public anger after the incident was "justified and absolute necessary". The CJI gave a detailed account of his views on the increasing number of cases of violence against women during the conference.
"What happened that day (December 16) was not something new... but it caught the imagination of the people…..it was fully justified. What started as a protest, as a mark of showing one's anger, it was all genuine, absolutely necessary....", Justice Kabir said.
The chief justice spoke about his nephew who had participated in the protests. "My nephew was also beaten up in the protest (at India Gate)….the protest was later hijacked," said Kabir.
He said he appreciated the peaceful protest and the number of people which had gathered. "I salute everybody who took part (in the protests). I wish I had been there, but I could not," he said.
But the chief justice also cautioned against violent protests. "We cannot afford certain types and groups of people from exploiting such situation to their own ends," he said.


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Chemotherapy for Non-Small-Cell Lung Cancer, Part II
Chemotherapy for Non-Small-Cell Lung Cancer, Part II
Linked Articles
ABSTRACT: The prognosis of patients with advanced non–small-cell lung cancer (NSCLC) remains poor. Systemic chemotherapy prolongs survival in this group of patients and palliates symptoms compared to best supportive care alone but more effective therapeutic strategies are needed. Novel agents that selectively target biological pathways of tumor growth offer hope of improving response and survival rates beyond what has been achieved with standard cytotoxic chemotherapy. Part 2 of this two-part article addresses the role of chemotherapy in locally advanced and advanced NSCLC, including the use of novel agents, considerations in elderly patients, and studies of second-line treatment.
As we noted in part 1 of this article, which appeared in the March 2003 issue of ONCOLOGY, the prognosis of patients with clinical stage IIIA or IIIB non-small-cell lung cancer (NSCLC) continues to be poor, with 5-year-survival rates ranging from 5% to 10% and median survivals from 12 to 15 months. Furthermore, untreated patients with advanced NSCLC have a median survival of 4 months, and a 10% to 15% 1-year survival rate. Although chemotherapy has traditionally had a small role in this disease, new drugs and combined strategies have shown some promise in improving survival rates.
Part 1 of this article explored the use of chemotherapy in early-stage NSCLC. In part 2, we review studies of chemotherapy in locally advanced and advanced NSCLC.
Locally Advanced NSCLC
At diagnosis, approximately 25% of patients present with locally advanced disease and are thus considered unresectable (stage IIIB). Historically, thoracic irradiation was the main treatment for these patients; however, its curative potential is poor. Several phase II and III studies have suggested a benefit with the addition of chemotherapy to radiotherapy.[1]
Up to the late 1980s, standard management of most patients with locally advanced NSCLC comprised conventional external-beam thoracic radiotherapy alone to a total dose of 60 Gy over 6 weeks, with a standard fractionation of 1.8 to 2 Gy per day. The median survival was less than 1 year, and 2-and 5-year survival rates averaged 15% and 5%, respectively.[ 2] A large Radiation Therapy Oncology Group (RTOG) phase II study aimed to optimize the total radiation dose with the use of a hyperfractionated schedule, and a doseresponse relationship was observed. The greatest benefit was seen with a dose of 69.6 Gy delivered over 5.5 weeks, which resulted in 1-and 3-year survival rates of 58% and 20%, respectively.[3]
In the continuous hyperfractionated accelerated radiotherapy (CHART) model, all treatment is compressed into 12 consecutive days by giving three fractions of 1.5 Gy/d at 6-hour intervals to a total dose of 54 Gy and continuing treatment over the weekend. A randomized clinical trial comparing CHART with conventional radiotherapy in 563 patients with locally advanced NSCLC showed a 24% reduction in the risk of death in the CHART group.[4]
A modification of this schema has been developed, in which patients are given the weekend off (CHART-WEL, ie, CHART weekend-less).[5] Modern techniques such as three-dimensional (3D) conformal radiotherapy might also significantly improve the efficacy of thoracic radiotherapy.
Sequential Chemotherapy and Radiotherapy
Many studies have explored the impact of the sequential addition of chemotherapy to radiotherapy.[6-8] The Medical Research Council–Institut Gustave-Roussy (MRC-IGR) overview included 3,033 patients with locally advanced NSCLC from 22 randomized trials comparing radiotherapy alone to radiotherapy combined with chemotherapy. The analysis showed a significant benefit for cisplatin-based chemotherapy combined with sequential radiotherapy, with a 10% reduction in the risk of death corresponding to an absolute survival benefit of 3% at 2 years and 2% at 5 years. However, identifying patients who might benefit from combined therapy is difficult because of the heterogeneity of the populations included in each study.
In the Cancer and Leukemia Group B (CALGB) 8433 trial, patients were randomized to either standard 60-Gy radiotherapy administered over 6 weeks, or two cycles of chemotherapy (vinblastine/cisplatin) followed by the same radiotherapy. The authors reported a significant improvement in survival favoring the chemoradiotherapy arm: Median survival was 13.7 vs 9.6 months, 5-year survival was 17% vs 7%, and 7-year survival was 13% vs 6%.[6,9]
In a confirmatory study led by the RTOG, patients were randomized to radiotherapy alone (60 Gy) vs two cycles of cisplatin/vinblastine followed by standard radiotherapy at the same dose or hyperfractionated radiotherapy (69.6 Gy).[10] This trial confirmed the improvement in median survival for the combined-therapy arm (13.7 vs 11.6 months), but hyperfractionated radiotherapy produced no significant benefit over standard radiotherapy.
The French Center for Experimental Bioinformatics (CEBI) 138 study included 353 patients, who were randomized to a sandwich regimen of induction and postradiotherapy chemotherapy (cisplatin/lomustine [CCNU, CeeNu]/vindesine/cyclophosphamide [Cytoxan, Neosar]) or to radiotherapy alone (65 Gy over 6 weeks). Median survival for the combined-therapy arm was 12 months, compared with 10 months for the radiotherapy-alone arm, and a survival advantage was observed in the combined-therapy arm (20% vs 12% at 2 years, P = .02).[11] In this multicenter study, local persistence or local failure after complete response occurred in over 80% of patients in both arms, without any statistical difference between the two arms. However, the incidence of distant metastasis decreased from 65% to 45% with the addition of chemotherapy (P < .001).[12]
Concurrent Chemoradiation
Two separate major cooperative groups have demonstrated superior survival in patients with locally advanced NSCLC following treatment with concurrent chemoradiation compared with sequential therapy.[13,14] In the Japanese study, the survival advantage favored the use of concurrent split-course radiation and mitomycin (Mutamycin), vinblastine, and cisplatin chemotherapy over sequential chemoradiotherapy. The overall response rate was significantly superior in the concurrent-therapy arm (84% vs 66.4%), with a median survival of 16.5 vs 13.3 months and 3- and 5-year survival rates of 27% vs 12.5% and 15.8% vs 8.9%, respectively.
These results were confirmed by the RTOG 94-10 trial, in which 611 patients were randomized to receive induction chemotherapy (cisplatin at 100 mg/m2 and vinblastine at 5 mg/m2) followed by standard radiotherapy (60 Gy) vs the same chemotherapy and concurrent radiation beginning on day 1 vs hyperfractionated radiotherapy and concomitant cisplatin and oral etoposide.[14] Among the 597 evaluable patients, median survival favored concurrent treatment, although the difference was not statistically significant (17 months in the concurrent-therapy arm vs 14.6 months in the sequential and 15.6 months in the hyperfractionated radiotherapy arm).
Because toxicities, especially esophagitis, were substantially worse for patients in the concurrent-therapy arm, the RTOG conducted a quality-of-life analysis called QTWiST (ie, quality-adjusted time without symptoms of relapse or toxicity from treatment), to determine if the improvement in survival outweighed the increase in toxicity. Assigning a range of intermediate weights, QTWiST confirmed the superiority of concomitant therapy over sequential therapy (P ≤ .001).[15]
A French study compared cisplatin/ vinorelbine (Navelbine) followed by standard radiotherapy with concurrent radiotherapy and cisplatin/ etoposide followed by three adjuvant cycles of vinorelbine and dose-attenuated cisplatin (the planned cumulative cisplatin dose in both arms was identical).[16] More than 75% of patients in this study had stage IIIB disease. A nonsignificant trend toward improved survival emerged at 2 years in the concomitant-therapy arm.
Newer Agents in Chemonaive NSCLC
Several new chemotherapeutic agents have shown activity in chemonaive NSCLC, and most of them have proven to be potent radiosensitizers in vitro. These drugs include paclitaxel, docetaxel (Taxotere), vinorelbine, gemcitabine (Gemzar), and irinotecan (CPT-11, Camptosar). Several phase II studies of these new compounds alone or in combination with cisplatin and concurrent irradiation in locally advanced NSCLC have been reported.
A series of pilot studies of paclitaxel as a radiosensitizing agent were conducted, and the recommended dose for further study was 55 mg/m2/wk in conjunction with simultaneous thoracic radiation to a total dose of 59.4 Gy.[17] Table 1 summarizes the results of several phase I and II studies in this setting.[17-20]
The combination of paclitaxel/ platinum and radiotherapy has also been widely explored. The weekly doses delivered are paclitaxel and cisplatin at approximately 40 mg/m2, and carboplatin (Paraplatin) at an area under the concentration-time curve (AUC) of 2, with a total radiation dose ranging from 60 to 65 Gy. Esophagitis is the most frequently reported side effect and appears to be the dose-limiting toxicity of this combination.[21]
Induction Chemotherapy Followed by Chemoradiotherapy
Another feasible approach involves the administration of two to three courses of induction chemotherapy followed by concomitant chemoradiotherapy. An induction regimen of cisplatin at 120 mg/m2 on day 1 plus a 3-hour infusion of paclitaxel at 135 mg/m2 on day 1 plus vinorelbine at 30 mg/m2 on days 1, 8, or 15 was evaluated in a Spanish phase II trial in 31 patients with inoperable stage III disease.[22] When feasible, all patients also received concurrent chemotherapy at the beginning of the radiation course and a course of hyperfractionated radiotherapy (69.6 Gy total dose) in the last week. The response rate was 58%, with a median survival of 16 months. The most common toxicity of chemotherapy was hematologic (febrile neutropenia, 13%; grade 4 neutropenia, 42%), and of radiotherapy, grade 2/3 esophagitis and dysphagia, which occurred in 41% of patients.
Langer et al used two cycles of paclitaxel (175 to 225 mg/m2 in a 3-hour infusion) plus carboplatin (AUC of 7.5), followed by thoracic radiotherapy (60 Gy in 2-Gy fractions) starting on day 43 concurrently with paclitaxel and carboplatin on days 43 and 64. The 1-year survival rate was 62% in the first 21 patients accrued into this trial.[23]
In a randomized phase II study, Curran et al compared (1) sequential chemoradiotherapy vs (2) induction chemotherapy followed by concurrent chemoradiotherapy vs (3) a concurrent approach using the combination of carboplatin and paclitaxel. The initial report was presented recently, and the interim survival results in arms 1 and 3 were sufficiently promising to support continued accrual.[24]
A synthetic allosteric modifier of hemoglobin (RSR13) was tested in combination with carboplatin/paclitaxel: 52 patients with stage III NSCLC received two cycles of carboplatin at an AUC of 6 and paclitaxel at 225 mg/m2 followed by radiotherapy (64 Gy) with daily RSR13 (75 mg/kg with possible adjustments to 100 or 50 mg/kg). The overall response rate was 87%, and 29% of patients experienced one or more episodes of transient RSR13-induced hypoxemia.[25]
Vokes et al recently reported the preliminary results of the randomized phase II CALGB 9431 study, which evaluated gemcitabine, paclitaxel, or vinorelbine with cisplatin as induction chemotherapy and concurrent chemoradiotherapy in stage III NSCLC patients. The response rate in all three arms was similar, but the gemcitabine/cisplatin arm showed the highest rate of grade 3/4 thrombocytopenia (53% vs 6% and 0% in the other arms) and esophagitis (49% vs 31% and 25%). The median survival for all patients was 18 months, with a 1-year survival rate of 66% (68%, 65%, and 63% for the gemcitabine, vinorelbine, and paclitaxel arms, respectively).[ 26]
Enhancing Radiosensitivity
Docetaxel is another new compound whose activity leads to stabilization of the microtubules that block mitosis in phase G2/M, thus playing a potential role in enhancing radiosensitivity to ionizing radiation. The maximum tolerated dose of docetaxel was 30 mg/m2/wk × 6 when administered alone with radiotherapy and 20 mg/m2/wk × 6 when administered in combination with carboplatin at an AUC of 2.[27]
Gemcitabine has a great radiosensitizing potential, but produces substantial toxicity when combined with radiotherapy. In a phase I trial, six weekly doses of gemcitabine at 1,000 mg/m2 during thoracic radiation (60 Gy in 2-Gy fractions) resulted in excessive nonhematologic toxicity, with esophagitis and pneumonitis developing in another three patients.[28] Even with the use of 3D radiotherapy, the maximum tolerated dose of gemcitabine was 190 mg/m2. Although the length of esophageal exposure was consistently reduced (from 71% for conventional twodimensional [2D] radiotherapy to 11% for the 3D approach), the doselimiting toxicity remained grade 3 esophagitis.[29]
In CALGB 9431, gemcitabine at 600 mg/m2 was safely administered during thoracic irradiation when delivered only on days 1 and 8 of a 3-week cycle. However, more grade 3/4 toxicity occurred in the gemcitabine arm during concurrent radiotherapy than in the paclitaxel/ vinorelbine arm.[26]
Other studies have shown that vinorelbine is a powerful radiosensitizer in vitro. In a phase I study, Gridelli et al reported the feasibility of the combination of thoracic radiotherapy and concurrent vinorelbine administered daily at a maximum tolerated dose of 4 mg/m2.[30] Recently, Garst et al reported the results of a phase II study, in which 36 patients with stage III NSCLC received vinorelbine at 5 mg/m2 three times a week and concomitant radiotherapy (66 Gy). The overall response rate was 56%, and the median survival was 20.7 months. Grade 3 esophagitis developed in five patients (14%).[31]
Concomitant vs Sequential Chemoradiation
In a phase II randomized study, Zatloukal et al directly compared concomitant and sequential chemoradiotherapy, administering cisplatin and vinorelbine in both arms at the same dose intensities. The concomitant approach resulted in major clinical activity, with an overall response rate of 85% and median survival of 20.7 months, compared to 45% and 14.1 months for the sequential arm.[32]
Irinotecan has also been evaluated in this setting. Based on the results of a phase I study, the recommended dose was determined to be 60 mg/m2 on days 1, 8, and 15 plus cisplatin at 80 mg/m2 on day 1 of a 28-day cycle administered concurrently with a split course of thoracic radiation (50.6 Gy in 2-Gy fractions).[ 33]
An ongoing European study is currently randomizing patients to radiotherapy alone vs daily carboplatin (15 mg/m2) in combination with radiation (66 Gy in 33 fractions over 6 weeks and 3 days), following induction therapy with cisplatin and vinorelbine. Among the first 190 randomized patients, 141 received the full dose of radiation therapy. Overall toxicity was comparable in both arms. An evaluation performed 1 month after the end of treatment showed an objective local response rate of 72% and local stabilization in 23%.[34]
Hypoxic cells are more resistant to irradiation (because of the radiosensitizing effects of oxygen) and also to standard chemotherapy (because hypoxic tumors often have poor blood flow). Tirapazamine is an investigational hypoxic cytotoxin with selective toxicity to hypoxic cells[35]; it has been shown to enhance survival in patients with advanced NSCLC when combined with standard chemotherapy compared to chemotherapy alone, and it could be an interesting drug to use as a radiosensitizer.[36]
Advanced Disease
Systemic chemotherapy for patients with advanced NSCLC prolongs survival and palliates symptoms compared with best supportive care alone, despite a modest improvement in survival reported in the MRC-IGR meta-analysis.[37] The low cure rate for NSCLC can be attributed to the high rate of metastasis at diagnosis and the inability to cure metastatic disease. The 5-year survival of patients with metastatic disease is less than 5%. The MRC-IGR meta-analysis included a total of 1,190 patients with advanced disease, and the results suggest that cisplatin-based chemotherapy may have a role in the treatment of such patients. This approach reduced the risk of death by 27% (P < .0001), improved median survival by 6 weeks, and improved the survival rate by 10% at 1 year.
The combinations of cisplatin/etoposide, cisplatin/vinblastine, and cisplatin/ vindesine were considered standard regimens for NSCLC in the early 1980s, with cisplatin being the cornerstone. Cisplatin is associated with a response rate of 20% when used as a single agent in this population. More recently, several new agents have become available for the treatment of NSCLC, including antimicrotubule agents (paclitaxel and docetaxel), a vinca alkaloid (vinorelbine), an antimetabolite (gemcitabine), and topoisomerase I inhibitors (topotecan [Hycamtin] and irinotecan). Randomized trials comparing new platinum-based combinations with older combinations or singleagent therapy with cisplatin underscore the greater therapeutic potential of the newer agents.
Newer Cisplatin Combinations
In four phase III trials comparing new cisplatin doublets with singleagent cisplatin, the authors reported the superiority of the combination therapies in terms of response, survival, and time to progression.[38-41] The activity of the new combinations was confirmed in at least five randomized trials, although survival times proved to be lower than those predicted by earlier phase II studies.[42-46] These trials all suggested that platinum-based chemotherapy regimens incorporating the new agents consistently offered median survivals of 9 to 10 months and 1-year survival rates near 40%.
Recent randomized studies have compared the most commonly used platinum-based doublets. The Eastern Cooperative Oncology Group (ECOG) 1594 study compared cisplatin plus 24-hour paclitaxel with cisplatin plus docetaxel, cisplatin plus gemcitabine, and carboplatin plus 3-hour paclitaxel. No differences in survival were observed between treatment arms.[47] This trial documented a disappointingly low response rate (15.3%) for paclitaxel/carboplatin (with the highest median survival of 8.3 months) and survival rates of only 21.3% and 21% for paclitaxel/cisplatin and gemcitabine/cisplatin, respectively. The 1-year survival rate was similar in all arms, ranging from 31% for the docetaxel/cisplatin arm to 36% for the gemcitabine/cisplatin arm. All regimens proved to be nearly equal in efficacy (Table 2), and although they are associated with different toxicity profiles and rates of toxicity, these differences may not necessarily have a significant impact on the patient's quality of life.
The Southwest Oncology Group (SWOG) conducted a randomized phase III trial of paclitaxel and carboplatin vs the SWOG standard treatment of vinorelbine/cisplatin (Table 3).[48] Both regimens produced survival outcomes comparable to those reported in ECOG 1594 despite higher response rates.
The Italian Lung Cancer Study Group compared cisplatin/gemcitabine vs paclitaxel/carboplatin vs cisplatin/ vinorelbine in untreated inoperable NSCLC.[49] An evaluation of toxicity data showed that all three regimens were well tolerated. Nevertheless, there was more myelosuppression with the gemcitabine- and vinorelbine-containing regimens (without clinical consequence), and the extent of thrombocytopenia was lower when cisplatin/ gemcitabine was administered on a 21-day schedule rather than the traditional 28-day schedule.
That said, the Italian study failed to demonstrate a therapeutic advantage for any of the three regimens in terms of survival or response (Table 4). These results are consistent with the results of the ECOG and SWOG trials, providing further evidence that all of these regimens remain reasonable choices for patients with advanced NSCLC.
A Spanish Lung Cancer trial showed no difference in efficacy with the use of a three-drug regimen vs a two-drug regimen. The two-drug regimen had a better toxicity profile, and there was no advantage to using a sequential doublet regimen without a platinum agent (Table 5).[50]
In addition, a trial by the European Organization for Research and Treatment of Cancer, EORTC 08975, revealed no significant differences in response between the paclitaxel/ cisplatin, gemcitabine/cisplatin, and paclitaxel/gemcitabine arms. In this trial, the nonplatinum regimen had an inferior survival rate, but this result did not reach statistical significance (P = .09).[51]


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Hydrangea Ballet Length Gown
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Give her the gift of beauty and comfort with this floral gown of a graceful length that is perfect for sleeping or lounging. Made of woven 100% polyester, it coordinates with the hydrangea long kimono. Sizes run S-3XL.


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12 Contemporary Jazz Etudes is written by the world-renowned jazz composer, arranger, saxophonist, bandleader, educator, and member of the Yellowjackets, Bob Mintzer. Designed for the medium to
Created for a wide variety of musicians, 12 Medium-Easy Jazz, Blues and Funk Etudes will appeal to both aspiring players and more experienced musicians. Accessible, yet with some challenges, this
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Written for a wide variety of musicians, 15 Easy Jazz, Blues & Funk Etudes will appeal to both aspiring players and to more experienced musicians. For the younger player, particular care is
Have a joyous Yuletide season year-round with this cheery collection of seasonal favorites arranged for all vocal or instrumental ranges with sumptuous accompaniments. Step in and take center stage
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Omega R&R Getaway Retreats
Omega R&R Getaways are a great way to unwind and renew your spirit. Join us on campus from May to October.
While you're here, enjoy a massage, facial, or other service at the Omega Wellness Center.More
From exclusive R&R classes to relaxing at the lake, you choose how to spend your time to create the best experience for you.More


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When using the Tabular model in SSAS, the deployment options screen offers four choices for "Query Mode": DirectQuery, DirectQuery with In-Memory, In-Memory, In-Memory with DirectQuery. Query Mode is used to specify the source from which query results are returned when you deploy the BISM project to the SSAS tabular model server. Here is a description of each, with the benefits and drawbacks:
In-Memory: This is the default. The data in the tabular model is processed and compressed using the xVelocity in-memory analytics engine (formerly called VertiPaq). This in-memory columnar storage engine has been optimized for high performance analysis and exploration of data. It provides fast query times for aggregation queries. However, there are some drawbacks:
DirectQuery: This mode uses relational data that is stored in a SQL Server database (it is similar to the ROLAP mode in a multidimensional model). It lets users retrieve data directly from a SQL Server data source in real-time. Any DAX queries on the data are translated by Analysis Services into equivalent SQL statements against the specified relational data source. To create a model in DirectQuery mode, you must first change the design-time environment so that it supports the user of DirectQuery mode (see Enable DirectQuery Design Mode). There are some additional benefits:
Be aware there are some design considerations if you are planning to use DirectQuery mode:
In-Memory with DirectQuery: This is a hybrid mode. By default, queries should be answered by using the In-Memory mode, however, the connection string from the client can instead choose to use the DirectQuery mode.
DirectQuery with In-Memory: This is a hybrid mode. By default, queries should be answered by using the DirectQuery mode, however, the connection string from the client can instead choose to use the In-Memory mode.
A hybrid mode provides you with many options:
Note that queries on a model deployed in DirectQuery mode can return different results than when the same model is deployed in-memory, because data is fetched directly from a relational data store and aggregations required by formulas are performed using the relevant relational engine, rather than using the xVelocity in-memory analytics engine for storage and calculation. For example, there are differences in the way that certain relational data stores handle numeric values, dates, nulls, and so forth.
Also note that after a project is deployed you can change the preferred query data source for a DirectQuery model by changing a property in SSMS. This is done by right clicking on the deployed database in SSMS and selecting properties and you will see a property called DirectQueryMode that is used to make the change. See Set or Change the Preferred Connection Method for DirectQuery.
In the end, your preference when data modeling should be to use the in-memory cache for your tabular model. DirectQuery is a better choice when you are using Power View and your scenario requires one or more of the benefits offered by DirectQuery.
More info:
Deployment Options for BISM Project
SSAS Tabular Model – Query Modes
Formula Compatibility in DirectQuery Mode
DirectQuery Mode (SSAS Tabular)
Difference between DirectQuery and In-memory mode in tabular mode analysis services
Upcoming DirectQuery vs Vertipaq Presentation (slides)
DirectQuery 101
Tabular Projects – DirectQueryMode and QueryMode
Using DirectQuery in the Tabular BI Semantic Model
Hybrid Mode in Tabular BI Semantic Model – Part 1, Part 2


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This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
Vitamin D is a steroid hormone with a broad range of biological effects ranging from the classical role as a mediator of calcium and phosphate balance to cellular differentiation and immune modulation. These effects impact normal and dysfunctional hematopoietic and immune function, which may allow an avenue for improved treatment and support of patients suffering from hematologic disorders. In this review, we will summarize the role of vitamin D in normal hematopoiesis, discuss ways in which vitamin D may improve outcomes, and discuss a potential role of vitamin D for treating hematologic disorders and modulating the immune system to improve the outcome of allogeneic stem cell transplant.
Vitamin D is a steroid hormone whose classical role is as a regulator of calcium and phosphate metabolism. This action, carried out through the renal, skeletal, and gastrointestinal systems has accumulated additional attention over the last several years with osteoporosis and bone health becoming an increasingly important concern for an aging population. Further investigation has discovered high rates of vitamin D deficiency in the United States population leading to a proliferation of recommendations for supplementation and investigation into the activity of the hormone. As investigators pursued the biochemical targets of vitamin D that influenced calcium homeostasis, multiple other roles of vitamin D signaling were discovered in various tissues that express vitamin D receptors (VDRs). VDRs have been identified on hematopoietic and lymphoid cells, leading to efforts to understand the role of vitamin D in blood cell development and immune system function. In this review we will attempt to give an overview of the role of vitamin D in normal hematopoietic and immune function, explore experience at exploiting vitamin D receptor signaling to treat hematologic disorders, discuss roles of the vitamin D receptor in immune recovery following hematopoietic stem cell transplant, and finally discuss the use of vitamin D in hematology and stem cell transplant patients.
Human vitamin D production requires the skin, liver, and kidney to convert 7-dehydrocholesterol in the skin to 1,25-dihydroxycholecalciferol, the active form of the hormone. Dehydroxycholesterol is converted to cholecalciferol (Vitamin D3) with UV light as a cofactor and then goes through two hydroxylation steps to 25-hydroxycholecalciferol and then 1,25-dihydroxycholecalciferol in the liver and kidney [
After being bound by activated vitamin D, VDR can form a homodimer or form a heterodimer with a retinoid X receptor. Those dimers can then binds to vitamin D response elements (VDREs) in promoters of target genes eventually leading to target gene transcription [
Aside from its ubiquity in affecting the transcription of many genes, VDR is present on a wide variety of tissues outside the intestine, bones, and kidneys, which are the organs most involved in the classical role of vitamin D. In the hematopoietic system the VDR receptor is expressed on various hematopoietic precursors as well as monocytes, some thymocytes, and activated B and T lymphocytes [
In addition to the role of vitamin D and the VDR in normal hematopoiesis and leukocyte differentiation the presence of the VDR on activated lymphocytes suggests a role in immune modulation on differentiated cells. VDR knock-out (KO) mice have a normal number of T and B lymphocytes but there are changes in the cytokine profile in VDR knock-out mice that affect the T-helper (Th) immune response. Inflammatory cytokines can elicit a cellular immune response termed "Th1" or a humoral immune response termed "Th2". The Th1 response is stimulated by IL2 and IFN-γ as major mediators, while the Th2 response is driven by IL-4, IL-6, and IL-10 [
There are seven studies of single agent vitamin D therapy for MDS. Koeffler and colleagues performed the first study of such a regimen in 1985, when they reported on 18 patients with MDS treated with single agent 1,25-dihydroxycholecalciferol up to a dose of 2 µg per day [
There are two studies looking at vitamin D2 analogues for MDS. Koeffler and colleagues treated 12 patients with low to high risk disease with a vitamin D2 analogue (Paracalcitol) with no responses noted; one patient had a doubling of his platelet count but succumbed to fatal fungal infection shortly afterward [
One notable study is a series of 30 patients treated by Motomura and colleagues in which patients were randomized to supportive care or 1-hydroxyvitamin D3 starting at 1 µg and titrated up to 4–6 µg if tolerated [
There have been efforts to combine vitamin D with other differentiation and cytotoxic agents. Blazsek and colleagues reported a case in 1991 of a patient with MDS who responded to a combination of
One promising path is the use of growth factors with differentiating agents. Ferrero and colleagues reported in 2008 on a study of 63 patients with MDS, excluding high risk patients with high numbers of blasts, treated with a combination of recombinant human erythropoietin as well as
Another group of studies has looked at combinations of vitamin D analogues as differentiating agents with cytotoxic chemotherapy. Ferrero and colleagues reported on experience treating 53 MDS patients with 13-
MDS, particularly in its lower risk forms, may be an indolent disease with a natural history extending over years. AML, on the other hand, tends to be fatal over weeks to a short number of months without effective treatment. Therefore, therapeutic plans that include only differentiating agents such as vitamin D have tended to be used only in patients with very treatment resistant disease or those at high risk for side effects of conventional cytotoxic chemotherapy. The only studies of vitamin D monotherapy in AML consists of a total of five patients treated in Japan in the mid 1980s of whom 4/5 had transient improvements in blasts and 1/5 had reported brief normalization of the bone marrow as reported by Irino, Takahashi, and Nakayama [
There are at least two series of elderly AML patients treated with low dose cytarabine regimens (subcutaneous in Europe and low dose IV in the US) combined with vitamin D analogue and another agent. Low dose cytarabine is a relatively well-tolerated cytotoxic regimen that had been the standard of care for elderly or unfit patients with AML. Slapak and colleagues in 1992 reported the use of cytarabine at continuous infusion (20 mg/m2/day) for 21 days with oral hydroxyurea (500 mg twice daily) starting the day preceding cytarabine and continuing for 22 days, and 1,25 dihydroxyvitamin D (0.5 µg twice daily) from the initiation of therapy until relapse or end of study [
The only study of vitamin D analogue combined with chemotherapy with a control group in the published literature is that reported by Hellstrom and colleagues in Sweden [
Unfortunately, the studies of vitamin D monotherapy for myeloid disorders suffer from limitations including lack of control group, variable response criteria, and unclear end-points, which makes drawing conclusions difficult. Ultimately, it seems a portion of patients with myeloid disorders may respond to vitamin D monotherapy but the numbers are likely small and the responses transient. Patients with lower grade disease and without blasts may have a higher likelihood of response. Combination therapies may show more promise but few of these include a control group and the use of other active agents makes it difficult to determine the activity of the vitamin analogues. The only vitamin D and chemotherapy combination regimen studied in a controlled trial failed to show benefit from the addition of vitamin D. It is possible that hypercalcemia
There are few studies examining the role of vitamin D in non-myeloid blood disorders. Multiple pre-clinical studies have shown activity of the vitamin D analogue EB1089 in the myeloma H929 cell line [
There is considerable interest in vitamin D analogues for their immune-modulatory effects. The last decade has brought a renaissance of immune therapies in oncology with the approval of rituximab, a humanized IgG1 targeting CD20 on lymphoma cells; ipalimumab, a CTLA-4 inhibitor that upregulates the immune response against melanoma; and promising results with PD-1 inhibitors, which also increase immune responses against many other malignancies. Hematologic malignancies have long been known to be susceptible to immune surveillance and allogeneic hematopoietic stem cell transplantation (HSCT) has been established as a curative therapy for many hematologic malignancies since the 1980s. HSCT is performed by replacing an individual's entire hematopoietic system, and hence his or her immune system, with that of another person. HSCT is the only potential curative therapy for several hematological disorders but presents two major barriers associated with the immune system. To allow a donor immune system to persist without being rejected, the recipient must receive immune suppressive chemotherapy, which causes severe reduction in immune cells and a significantly increased risk of infection. Post-transplant, when the donor immune system has grown, it may attack or reject the recipient's tissues in a process called graft
Vitamin D via the VDR has a role in immune regulation and vitamin D analogues are well-established therapies for some autoimmune conditions such as psoriasis. This effect is likely due to the known effects of vitamin D on activated T and B cells that may affect signaling, tissue targeting, or immune regulation. Of course, given their roles in monopoiesis and macrophage activity, VDR stimulation appears to be crucial to the activity of antigen presenting cells and this is felt to be responsible for the role VDR activity seems to play in response to infections. For example, in tuberculosis infection decreased vitamin D levels appear to increase the risk of tuberculosis disease and supplementation may help resolve infection [
Middleton and colleagues reported a cohort of 88 patients with myeloid malignancies whose VDR gene polymorphisms and those of their 80 sibling donors were analyzed and correlated to outcomes [
Finally, Bogunia-Kubik and colleagues published an analysis of 123 Polish patients with the inclusion of those receiving unrelated donors [
Clearly, in its mediation of immune signaling the vitamin D receptor appears to have an impact on immune reconstitution after HSCT and subsequent risks of infection, graft
Finally, at the same time vitamin D status is examined as a factor in disease outcomes and the non-classical roles are explored, the classical role of vitamin D in regulating bone calcium deposition and bone density remains critical. Two populations in which significant attention has been paid to vitamin D status are patients after allogeneic stem cell transplant, who are known to have significant endocrinologic and nutritional risk factors for deficiency related to their treatment, and patients with multiple myeloma, a disease intimately related to bone health.
Pediatric allogeneic stem cell transplant recipients are at particular vulnerability to bone loss due to the high risks of total body irradiation and conditioning chemotherapy to cause endocrine failure syndromes prior to final adult growth and the deposition of primary bone mass in the 20s. Moustoufi-Moab and colleagues looked at 55 patients who received allogeneic transplant between the ages of 5–26 and who were at least three years from the procedure and compared their bone mineral density scores to healthy controls [
Studies of adults have been contradictory in regards to assessing vitamin D status of allogeneic stem cell transplant survivors, though timing at which assessment is done likely has a significant effect. Joseph and colleagues assessing patients on day 0 and day +100 found 70% and 58% of patients to be vitamin D deficient, respectively [
Given these findings, there are clear recommendations on management of vitamin D status and bone health for patients after allogeneic stem cell transplant. UK guidelines recommend DEXA scanning for all patients expected to be on chronic (>3 months) of corticosteroid therapy as well as measurement for and correction of vitamin D deficiency [
Myeloma is a plasma cell malignancy that causes lytic bone disease as one of its hallmarks. Given the importance of vitamin D in bone formation, the role of vitamin D supplementation in myeloma has gained some attention. Myeloma is known to promote osteoclastic over osteoblastic activity as a factor in causing lytic bone lesions. This activity can be reversed by one of our newer and best agents for myeloma, bortezomib. It has been shown that vitamin D significantly promotes the ability of bortezomib to inhibit osteoclast proliferation and heal bone lesions [
At the same time the role of vitamin D has been examined clinically and observationally. Badros and colleagues surveyed 100 consecutive patients seen in University of Maryland cancer center with multiple myeloma and found 75% of patients were frankly deficient or insufficient [
Ultimately, studies have revealed that post-allogeneic stem cell patients are vulnerable to endocrinopathies and bone mineral loss. Supplementation of fairly low doses seems to correspond to adequate levels and despite somewhat unclear direct relationships between vitamin D level and bone density at one point in time it seems prudent to maintain normal levels in patients particularly vulnerable to bone disease. Similarly, data that vitamin D is required for bisphosphonate activity and may help bortezomib, an important agent used for treatment of myeloma, suggests that those with lytic skeletal disease should at least receive replacement to assure a normal vitamin D level.
Ultimately, the ubiquity of the vitamin D receptor and the myriad physiologic effects that have been found suggest multiple mechanisms of potential benefit from the use of Vitamin D in the treatment of hematologic disease. In the hematopoietic system there is evidence that the vitamin D pathway affects both differentiation of cells and their ultimate activation once differentiated, although the importance in various disease states remains poorly understood. It can be said with some level of certainty that vitamin D promotes differentiation of monocytes and macrophages under certain conditions, and there is a suggestion that at least a fraction of cases of myeloid disorders (
The authors would like to thank Howard Bailey for his advice regarding direction of this manuscript.
The authors declare no conflict of interest.


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York Street gardens will close at 3 p.m. on Friday, July 21 for a concert. Other early closings.
- Time to celebrate fall: grasses are glowing in the late afternoon light and the leaves are still changing colors all over the Gardens. Come visit Denver Botanic Gardens soon! Every garden has something visual to offer. Or take a walk at Denver Botanic Gardens at Chatfield and enjoy nature and our working farm. Summer is over, and so is the 2013 Summer Concert Series at York Street and Chatfield. Did you make it to most of the concerts or just one? Please read these terrific after-concert reviews from Denver Botanic Gardens members Rick and Sue Ann Hum. And enjoy these stunning photos taken by Kate Battan, another member of the Gardens. Thank you, Rick, Sue Ann and Kate, for these memories of another great summer of concerts. Be sure to check out this wonderful gallery of photos taken by Kate at the Summer Concert Series.
The 2013 Summer Concert Series was hands-down, the best season series ever. The shows were diverse, included old-time favorites, up-and-coming acts, local talent and internationally known gems.
The season started with Emmylou Harris and Rodney Crowell. As the saying goes, the best duet is Emmylou Harris and whoever is with her. Emmylou and Rodney were very well connected. Their guitar styles were nicely complimentary and their vocals superb. The lead guitarist, Australian Jedd Hughes stole the show for many of the songs. As Candace Horgan reported in heyreverb.com, ". . . much like in the Hot Band, Harris and Crowell were surrounded by strong instrumentalists." What great fun, dancing and partying with friends.
Tony Bennett is an incredible talent with great stage presence and charm. He brought a welcoming lounge act vibe to the Gardens accompanied by his quartet of piano, guitar, bass and drums plus his youngest daughter Antonia Bennett. Tony Bennett can still sing well and does perform with a twinkle in his eye and a little bounce in his step. Antonia sang about four songs with the quartet as a warm-up act and then returned to the stage to sing a duet with her dad.
After a rain delay of more than an hour-and-a-half, the David Byrne & St. Vincent show did go on; and what a show it was. If this wasn't the best concert of the season, it was clearly the most creative, best choreographed and with the most interesting musical arrangements. With a 9-piece band (2 trumpets, 2 trombones, 2 woodwinds, sousaphone, drums and keyboards) behind David Byrne and Annie Clark (a.k.a. St Vincent) the music was fantastic, with more variety than you would think possible. David Byrne is a musical magician and Annie Clark was fantastic with her vocals, guitar playing and stage presence. Well worth the wait and the wet. Their clever exit strategy was to bring on Denver's own itchy-O marching band to totally confuse the audience.
Arlo Guthrie is known for his story telling and he didn't disappoint. The show was on his father's (Woodie Guthrie) 100th celebration of his birth. He told stories about his dad, Leadbelly, Ramblin' Jack Elliot and his own life. Between the stories he did some wonderful guitar and piano playing to accompany his vocals. The Trisha's were a good opening act with wonderful harmony and their own guitar playing. After two previous night's heavy rain, the light drizzle for 5 minutes was a relief. There was even a crescent moon through the thin clouds.
As expected, Bruce Hornsby & the Noisemakers put on a great show. What fun, up-beat, great music; very fitting for a celebration. The Noisemakers were excellent; known for improvisational jams. It was interesting to see how their eyes were glued on Hornsby to see what might happen at any moment. Of course for some of us, this will be a very memorable show.
Steve Martin came out on stage immediately as the show started and he was very much in control of center stage. His prepared and ad-libbed humor added to the great music on stage, especially the comments about the stagehand steadying the 5,000 pounds of speakers when the wind picked-up. Edie Brickell was very good, but was not featured as much as expected. The Steep Canyon Rangers were excellent accompaniment and an act of their own.
The end of July brought what was probably the surprise concert of the summer. Even for those who had seen Elephant Revival, this pairing was an unexpected pleasure. The Carolina Chocolate Drops' cello with fiddle, banjo and other instruments provided a wonderful sound. The audience didn't want to see this incredible opening act go at the end of their set. But Elephant Revival came out and showed they have a very unique and wonderful sound also, especially with Bonnie Paine's washboard and vocals. The evening was topped off with an encore that included both groups, which really delighted the crowd.
The Indigo Girls of course thrilled the audience, who responded by singing the lyrics of many of their songs. Amy Ray seemed to really want to excite the band and did so along with the response of the audience. The warm-up act of von Grey was surprisingly wonderful. What an incredible family of young musicians.
Suzanne Vega played and sang a number of her songs. She is a very interesting songwriter. Bruce Cockburn sang and played wonderfully. It's hard to understand why his work is not as appreciated in this country as it is in Canada. He is a fine songwriter, guitar player and pianist. He got the audience to join him in singing Wondering Where the Lions Are.
Joey Ryan and Kenneth Pattengale (The Milk Carton Kids) provided the best opening act of the season. Their music, guitar playing and voices were outstanding, but it was their humor and stage presence that kept the audience clinging to every word and action. Josh Ritter rocks! The Royal City Band rocks! His followers (who know every word, of every verse, of every song) rock. The show was great fun with the Milk Carton Kids, Josh Ritter and the Royal City Band. It's too bad none of them are cute. This was another of the best shows of the summer.
The gates were held for about 15-20 minutes to let a storm cell pass, once the gates were open, the skies opened as well. Lightning was still visible in the distance when Shawn Colvin took the stage. She said she was glad the rain passed, because she didn't want to have to sing all her "rain songs." Colvin was her typical defacing self, but played wonderfully and sang very well. She also thanked her fans for continuing to support her music. Martin Sexton came on stage and used a great trick to get the audience's attention, by pretending his mic was not working. He not only got the audience's attention; he never lost it. His guitar playing was fantastic and with his vocalization of percussion, trumpet and other parts, if you couldn't see the bare stage, you would have thought there were others with him. He played very upbeat music that got the crowd to the dance floor. It was a great, fun show with two very good solo acts.
Hazel Miller Band of Denver was a superb opener for Michael McDonald. She said they wanted to get everyone up and moving to be ready for McDonald. They did that and more. They played a very tight set. Hazel's voice was strong, clean and beautiful. The band highlighted the players in short, but fantastic solos in a few of the songs. Michael McDonald played a long, continuous set with a great mix of Doobie Brother's favorites; some of the iconic Michael McDonald numbers, and new material. The band played well and seemed to enjoy the atmosphere.
Chris Isaak did the best show he's done at the Gardens, according to many of the people who have seen 3, 4, or more shows. His voice was wonderful. His guitar playing seems to get better and better and his ability to ignite the crowd by moving through the audience stopping at a few places and continuing to sing and play. He even sent his talented, 12-string / 6-string guitar accompanists, Hershel Yatovitz out for a journey through the back half of the audience.
Melissa Etheridge came to play and to rock. Eschewing most of the songs from her new, good 4th Street album, she played music that excited, pleased and got the crowd up and dancing. She played continuously through the show. She would give the band members breaks, playing solos or bringing one of the members back on stage to do various, interesting duets. One duet had four hands on the lead guitar player's guitar; another had Melissa playing cords while her drummer did the "strumming" with his drumsticks. She was energetic and as the recent press indicated, she uncharacteristically played lead guitar with confidence and skill.
We all look forward to more great music at the best venue in the Rocky Mountains.


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Design-Driven Hostels
The word hostel suggests bunk beds and grungy showers, but a new breed is redefining the genre. In Istanbul, Bunk (photo) has a clean, white aesthetic and marble bathrooms. The new branch of Germany's wacky Superbude, in Hamburg, has a rock-star suite with a stage; and Pod 39 in New York City has a concierge service and food by Spotted Pig chef April Bloomfield.


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Lukid doesn't hesitate to hold back his viper-tongue with four charmingly titled tracks that see a Lukid, at first, restrained and composed, presenting soulfully structured slo-mo house with a hip hop bounce a la Moodymann. However, two tracks in and Lukid appears to lose himself in a fit of pent-up wrath - throwing down unstructured rhythms and warped bass lines sifted through a fuzzed-up filter of distortion and filth.


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Don Trip & Starlito Announce 'Stepbrothers 2′ Tour
After earning SPIN magazine's "Best Rap Album of 2011″ title with their 'Stepbrothers' project, Don Trip and Starlito are back it with their latest release, 'Stepbrothers 2,' which dropped today (Oct. 15). To help promote the new album, the southern duo has announced a 15-date tour kicking off tomorrow (Oct. 16) in Jacksonville, FL.
Ready to take in the crowd reaction to their 'Step Brothers' follow up, Don Trip says, "For me, I felt like it was a brand new project, and not a part 2 so to speak." He continued, "We needed it to be bigger; treat it like an album and not a mixtape. It took more preparation."
The two stuck with their tradition of embedding messages in their lyrics, and in the process found themselves paying homage to Third Coast greats Pimp C and Outkast with the track, 'Pimp C 3000,' which "takes threatening verses [and places them] over a ricocheting beat." And while today marks the release of the new mixtape, it also sits as the first day fans can watch the visuals to 'Leash on Life,' the track that brings social commentary on current topics like school shootings, bullying, the hood, poverty and more to life.
Check out Don Trip & Starlito's tour schedule below.
October 16th Roc Bar – Jacksonville, FL
October 17th Orpheum – Tampa, FL
October 18th Eve Event Space – Miami, FL
October 19th Backbooth – Orlando, FL
October 21st Workplay – Birmingham, AL
October 22nd The Lyric – Oxford, MS
October 23rd Juanita's – Little Rock, AR
October 24th Antone's – Austin, TX
October 25th Rack City – Nashville, TN
October 26th The Loft – Dallas, TX
October 29th Reggie's – Chicago, IL
October 31st Fahrenheit Ultra Lounge – Lansing, MI
November 1st Suite 38 – Indianapolis, IN
November 2nd Kicker's Club Oak – Grove, KY
November 10th Jim Porter's – Louisville, KY


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Upper Playground Store :: 1-866-7WALRUS :: MICKEY DUZYJ-LOSERS
Hmm, well, I guess so. Suddenly, me never winning makes a lot more sense.
So, you like artsy, bright and in-your-face t-shirts? Well, this is your dream shirt. This hi-fi color is nothing, but unique and in your face. Besides, the fully printed shirts are the bets.Added 9 Years Ago from Upperplaygroundstore


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The Hollywood Reporter
In a day brimming with all manner of casting news that began with Tom Cruise playing Van Helsing of all things, yet more additions have come our way. Next up … WER.
According to The Hollywood Reporter, Vik Sahay, best known for his comedic work on NBC's "Chuck" and the recent American Reunion movie, is moving into horror movie territory, closing a deal to join the cast of WER.
Sahay joins A.J. Cook ("Criminal Minds"), Simon Quarterman (The Devil Inside) and Brian J. O'Connor (Epic Movie) to round out the main cast of the werewolf flick being directed by William Brent Bell (The Devil Inside).
The story is set in Paris and follows an investigation of a gruesome slaying of a family. Sahay is a member of the defense team which learns its client (O'Connor), who is a suspect in the slayings, is a werewolf.
WER starts shooting in Bucharest, Romania this month.
Steven Schneider, producer of The Devil Inside, The Tall Man and the Paranormal Activity films, is producing the film with Matthew Peterman (who wrote the screenplay) and Morris Paulson through their production company Prototype. Robert Hall and his newly re-branded Almost Human Inc. is tackling the makeup and visual effects for WER.
More as it comes.
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|You are in: UK: Scotland
Monday, 8 October, 2001, 11:59 GMT 12:59 UK
MSP learns about sectarian divide
Liberal Democrat Donald Gorrie has been speaking to politicians and police in Belfast about their first-hand experiences of sectarianism.
The MSP is currently drafting a Bill which would see sectarianism made an offence in Scotland and punishable with a jail term of up to seven years.
During a three-day visit, Mr Gorrie will meet a number of experts, from academics and police to community leaders and members of human rights organisations.
The Bill, which has received enough backing at Holyrood, proposes to make sectarian behaviour an aggravation of a criminal offence, and to create a code of conduct on tackling sectarian behaviour.
Consultation process
Mr Gorrie said the need for such a Bill had been underlined by recent attacks on mosques and Muslims in the wake of terrorist attacks on America.
He added: "Although there are many differences between Scotland and Northern Ireland, sectarianism has a common historical basis.
"So we can learn a lot from the Irish in tackling our own Scottish sectarianism."
Mr Gorrie's visit is part of the consultation process required before the Bill is put before parliament.
The MSP said he would be circulating a formal consultation document to many groups in Scotland in the next fortnight.
Mr Gorrie has previously claimed that his proposals to outlaw sectarianism in Scotland had been "largely adopted" by Westminster.
He made the claim after home secretary David Blunkett announced plans to widen the law on incitement to include religious as well as racial hatred.
A spokeswoman for the executive said: "When the Bill is available, we will listen to the debate and consider arguments in relation to it before reaching conclusions about whether to support it."
Mr Gorrie says existing laws are strong against racial harassment, but do not mention sectarian or religious harassment.
He hopes the Bill will be drawn up, introduced to parliament and placed before a committee for stage one consideration by September 2002.
See also:
02 May 01 | Scotland
New move to end sectarianism
08 Feb 01 | Scotland
Fury at MP's Taoiseach warning
29 Apr 00 | Scotland
Woman's bid to beat bigotry
27 Jan 00 | Scotland
Protestant trust stirs sectarian debate
22 Sep 99 | Scotland
Violent reminder of sectarianism
Internet links:
The BBC is not responsible for the content of external internet sites
Top Scotland stories now:
Links to more Scotland stories are at the foot of the page.
Links to more Scotland stories
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Instant Online Payday Loans Alberta
You have probably heard about Instant Online Payday Loans Alberta, nevertheless, you aren't confident that they are right for you. These companies offer short-term loans to the people who are developing a difficult time financially. Sounds great, right? It can be if you find out all you need to know before applying for just one. Here are some tips to assist you with these loans.
When considering a payday loan, though it can be tempting be sure not to borrow greater than you can afford to pay back. For example, if they allow you to borrow $1000 and set your car as collateral, nevertheless, you only need $200, borrowing excessive can lead to the loss of your vehicle if you are not able to repay the complete loan.
If you take out a payday loan, just be sure you can afford to cover it back within a couple of weeks. Instant Online Payday Loans Alberta should be used only in emergencies, when you truly haven't any other alternatives. When you take out a cash payday loan, and cannot pay it back immediately, a couple of things happen. First, you have to cover a fee to hold re-extending your loan until you can pay rid of it. Second, you keep getting charged increasingly more interest.
Make sure you borrow merely the bare minimum when looking for Instant Online Payday Loans Alberta. Many people have emergencies surface and need more money, nevertheless the interest rate on a payday loan is a lot higher than what you would pay to your bank or credit card company. Keep the costs of the loan lower by only borrowing the thing you need, and make up with your payments,
If you do not know much of a payday loan but you are in desperate need of one, you may want to consult with a loan expert. This could be also a friend, co-worker, or family member. You want to you should always be not getting cheated, so you know what you are receiving into.
Sometimes we can all work with a little help financially. If you find yourself with a financial problem, so you don't know where you can turn, you can aquire a payday loan. A cash advance is a short-term loan you could receive quickly. There is really a bit more involved, and these tips will help you understand further by what these loans are about.
Payday loan companies work around the laws to charge a fee the highest amount. These loans cost a specific amount (say $15 per $100 lent), which are just interest disguised as fees. As a result, credit can accrue around ten times the eye rate of your standard loan.
Beware of falling in a trap with payday cash advances. In theory, you would pay the loan last one to two weeks, then move on with your life. In reality, however, many people cannot afford to settle the loan, along with the balance keeps rolling over to their next paycheck, accumulating huge amounts of interest with the process. In this case, many people get into the career where they can never afford to repay the loan.
Be aware of the deceiving rates you are presented. It may seem being affordable and acceptable being charged 15 dollars for each one-hundred you borrow, but it will quickly accumulate. The rates will translate to get about 390 percent in the amount borrowed. Know exactly how much you will be needed to pay in fees and interest beforehand.
Only borrow how much cash that you absolutely need. For instance, should you be struggling to settle your bills, then this money is obviously needed. However, you shouldn't borrow money for splurging purposes, such as eating out. The high interest rates you will have to pay later on, are not worth having money today.


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> you'd be much better served by > putting a big NVRAM cache in front of a fast disk array I agree with the point below, but I think price was the issue of the original discussion. That said, it seems that a single high speed spindle would give this a run for its money in both price and performance, and for the same reasons Mike points out. Maybe a SCSI 160 or 320 at 15k, or maybe even something slower. Rick pgsql-performance-owner(at)postgresql(dot)org wrote on 07/26/2005 01:33:43 PM: > On Tue, Jul 26, 2005 at 11:23:23AM -0700, Luke Lonergan wrote: > >Yup - interesting and very niche product - it seems like it's only obvious > >application is for the Postgresql WAL problem :-) > > On the contrary--it's not obvious that it is an ideal fit for a WAL. A > ram disk like this is optimized for highly random access applications. > The WAL is a single sequential writer. If you're in the kind of market > that needs a really high performance WAL you'd be much better served by > putting a big NVRAM cache in front of a fast disk array than by buying a > toy like this. > > Mike Stone > > ---------------------------(end of broadcast)--------------------------- > TIP 2: Don't 'kill -9' the postmaster
Next: From: Jim C. Nasby Date: 2005-07-26 20:05:00 Subject: Re: [IMPORTANT] - My application performance Previous: From: John A Meinel Date: 2005-07-26 19:51:11 Subject: Re: faster INSERT with possible pre-existing row?


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Venue :
Fiera Milano Nuovo Polo Exhibition Centre (Rho)
Country :
Address :
Strada Statale del Sempione, 28, Milan, Rho, Italy
Industry :
Apparel & Fashion
Organiser :
Organiser :
Book Hotels near Exhibition
MIFUR - International Fur and Leather Exhibition 2015 will showcase a designer range of leather garments, quilted jackets, fur garments, accessories, buttons, tannery services and much more. In its 20th edition, the event will attract over 180 exhibitors of the Italian and international fashion, 14,000 visitors from all over the world. Know about latest fashion trends from leading international designers of infinitely versatile fabric. Grab this opportunity to associate with representatives from leading brands and professionals from Italian as well as international fashion industry. Visit new areas at the show like B.box, Glam Av K.Point and Crossover. Mark your presence at this grand fashion event and book a stay with one of top-notch hotels close to Fiera Milano Nuovo Polo (Rho). Make easy online bookings at Exhibitioncentrehotels and avail great accommodation discounts near the event. Explore the world of leather, technical fabrics, duvets innovative fur designs and much more.
Event is Over
Please fill the form to contact the organiser as a participant or as a visitor


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Tesla (TSLA) has announced plans to expand its Supercharger network in Europe.
The company is planning on adding 30 new service centers and retail stores across the continent. This expansion will allow Tesla Model S owners to have more access to stations where they can refuel their vehicle for free.
"By the end of this year, we expect you will be able to travel almost anywhere in Europe using only Superchargers," CEO Elon Musk said. There are currently 14 Supercharger stations in Europe which pale in comparison to the 78 in North America.
Tesla said it expected sales in Europe and Asia to be twice as high as North America by the end of 2014.
TSLA stock is up 1.7% in early trading Tuesday.


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There are plenty of ways to work sabermetrics into a broadcast without teaching a math class.
Should One Strike Make This Much Difference?
It's time to take a fresh look at when to swing on 3-0 counts — and especially 3-1.
The Case for Confronting Sabermetric Skeptics
How to spread the word about sabermetrics, and why that's important.
What Can You Find on the Free Agent Market?
Breaking down the numbers to figure out what your team is likely to find waiting for it on the free agent market.
Did Adam Dunn Ruin Baseball?
Here's a defense of the approach that emphasizes the duel between pitcher and batter.
Positional Versatility and the Zobrist Fallacy
Versatility is a valuable skill that should be celebrated.
Obsessing Over Perfection
The difference between a perfect game and a one-hit shutout is negligible. But the emotion we pour into that tiny difference is immense.


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About annaha
Genealogist researching multiple family lines for my family and others. Special interests on Fold3 include researching military and political service.
Related Pages
Making your own Profile Page is easy, free and quick. Join now and start sharing your insights and discoveries.
- Colorado, United States
- Member since 06 Jul 2007
- Notify Me


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7 Recommendations
AGD's recommendation
Because sometimes your boyfriend just can't grow facial hair.
My Collections:
fluxified's recommendation
what can i say? i HATE facial hair, he shaves for me, i should let him wear a mustache now and then...
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HeyJude's recommendation
Are you sick of trimming and shaping your facial hair into the perfect mustache? Or are you a girl and are unable to grow a mustache? Well here is your solution: self adhesive mustaches! For your next mustache party!
My Collections:
anjol35's recommendation
Just what I need when my sister is looking for me to babysit.
chad's recommendation
Don't lie, we all wish we has a mustache. The only problem is actually growing one. With these, you can rock one one night and be clean shaven for work the next day. Oh yeah, and you can switch up the style, shape and color.
kryz's recommendation
A variety to suit your mood.
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roxygrl's recommendation
Ever wondered what you would look like with a mustache? Now you can see for yourself with these hilarious stick on mustaches! Set includes a variety of seven shapes, colors and sizes!
My Collections:


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Zoo Tots - One Tree Makes the Difference
Join us for this class on March 7 or 8.
Explore the 3D rainforest to discover what trees do for us and the rainforest animals.
Ages 2 & 3 meet at 10am. Ages 4 & 5 meet at 11:15am.
$5 per child for Hattiesburg Zoological Society members :: $7 per child for non-members
To register your child, email email@example.com.


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Box Score and play by play(pdf)
Audio from Badger Nation
Wisconsin coach Bo Ryan -
Jared Berggren, Ben Brust and Sam Dekker -
Stories from Badger Nation
Redemption for the Badgers against Iowa and the free throw line
Notes: Berggren equaled a career-high seven blocked shots, tying for the third-most in UW single-game history ... Senior Ryan Evans finished with 15 points and nine rebounds. Evans was 5-of-7 from the FT line, including a pair of free throws with four seconds remaining in the second overtime to give Wisconsin a 74-70 lead ... Junior Ben Brust scored 18 points, marking his ninth double-digit scoring performance of the season ... Iowa's 70 points snapped a Wisconsin 20-game streak of holding opponents to 60 points or less at the Kohl Center.
Join the Badger conversation on Facebook! Go to our Facebook page and "like" us!
For more Badger sports news, notes and discussion, especially on game day, follow Badger Nation on Twitter @TheBadgerNation


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This content has been marked as final. Show 4 replies
1. Re: Using OLAP DML to maintain measuresnasar.ali-khan at -Oracle Aug 8, 2012 7:01 PM (in response to 952749)If its a standard-form dimension created through AWM, then you can only load/refresh it through DBMS_CUBE.BUILD procedure. Read documentation at http://docs.oracle.com/cd/E11882_01/appdev.112/e16760/d_cube.htm#CHDFCJBF
If its a custom dimension created through OLAP worksheet command line or through DBMS_AW.EXECUTE , only then you have to write your own OLAP DML program to maintain it.
2. Re: Using OLAP DML to maintain measures952749 Aug 8, 2012 8:28 PM (in response to nasar.ali-khan at -Oracle)Thanks for your reply. I'm experienced in writing code to maintain structures, but in this case I want to populate stored measures with results that can only realistically be calculated in programs. So I have an OLAP dml program that can do that, and I can run it from a Cube Script or a Maintenance Script. Only I would like to be able to get some logging and diagnostics during the run, and to be able to see the results from my error trapping. I can outfile to a log file, but then I have to go outside the system to see it. It would be better to see stuff in the Summary/Detailed logs. Can this be done from OLAP dml?
3. Re: Using OLAP DML to maintain measuresDavidGreenfield Aug 9, 2012 12:32 PM (in response to 952749)You can run an insert statement from the OLAP DML to populate any table you want. The only complication is that the rows will only be persisted if the transaction is committed, and you can not (should not!) commit the transaction during the current build since it will persist bad data in the case of a failure. A possible solution is to write a PL/SQL procedure that begins an "autonomous transaction" and make this be responsible for logging. E.g.
You would then call your PL/SQL procedure from OLAP DML every time you wanted to log a record.
4. Re: Using OLAP DML to maintain measuresBud Endress - Oracle-Oracle Aug 10, 2012 12:54 PM (in response to 952749)Look at the OLAP DML help (easily accessable through AWM's OLAP Worksheet) and review the SQL command. This allows you to issue SQL commands (e.g., SELECT into a cube variable, INSERT into a table). Pay attention to David Greenfield's warning about issues COMMITs. A COMMIT in OLAP DML is a COMMIT in the database and will commit anything during that session, including data during the build (if that's where the script is being run).
What types of info are you trying to log? Does it need to be run within the cube script or can it be run in a separate session (in which case a commit will not affect the sessions running the build script)?


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At Walmart, which is many peoples' grocer, clothier, and auto supply shop, long lines would cost them a lot of business.
Most men are of standard size and can go to a clothier and buy a ready-made black suit.
He was certainly a Kentish man, and probably the son of a London clothier.
No clothier may keep more than one wool loom in his house, because many weavers do not have enough work to support their families.
But Government may spend more than the 1000 with this clothier; they may spend 10,000.
Dismissing us with a curt good-day, he retired, while we followed the vice-consul to the clothier's.
But the package was marked 'Strawbridge and clothier' on the box.
I had not then learned that one can seldom make a more fatal mistake than to allow a clothier or tailor to choose for you.
Dear Doctor: The bearer is a fat Wiltshire clothier; make the most of him.
Can you direct me to a clothier, where I can obtain suitable clothes?


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Configuration Guide
Configuring IPSec VPN between IPAQ with Movian client and Cisco IOS Easy VPN Server
Figure 1
Network Diagram
This document describes how to configure a handheld computer and Cisco IOS router for IPsec VPN connectivity. With VPN connectivity, the handheld computer can connect to Intranet servers privately over the public Internet. The sample configuration presented in this document uses the Movian VPN client software application, the Cisco IOS Easy VPN Server, the IPAQ handheld computer at the remote end, and Cisco 7200 as the server.
The handheld computer-to-Cisco Easy VPN router sample configuration is based on the following assumptions::
- The IP address at the Cisco Easy VPN Server is static.
- The IP address at the handheld computer is static or dynamic.
- All traffic, including Internet traffic, from the Easy VPN Client is forwarded to the hub.
- Traffic from the remote host is forwarded after applying Network Address Translation/Port Address Translation (NAT/PAT).
Components Used
The sample configuration uses the following releases of the software and hardware:
Figure 1 illustrates the network for the sample configuration.
The information presented in this document was created from devices in a specific lab environment. All of the devices started with a cleared (default) configuration. If you are working in a live network, it is imperative to understand the potential impact of any command before implementing it.
Movian Client Configuration Options
The Cisco Easy VPN implements the Cisco Unity Client protocol, which simplifies configuring the detailed information on the client router because most VPN parameters are defined at the VPN remote access server. The server can be a dedicated VPN device, such as a VPN 3000 concentrator or a Cisco PIX Firewall, or a Cisco IOS router that supports the Cisco Unity Client protocol. The sample configuration uses the Cisco 1751 for the Easy VPN Server.
This sample configuration uses client mode with the Movian VPN Client. In Client mode, the entire Movian VPN client address undergoes NAT to the mode config ip address that the Easy VPN Server provides.
The Movian VPN Client forwards the Internet traffic to the Easy VPN Server. Direct access to the Cisco 806 Easy VPN Client by traffic other than the encrypted traffic from the Easy VPN Server is denied. An alternative configuration of the Cisco Easy VPN Server called split tunneling forwards the Internet traffic directly without encryption.
For additional information about configuring Easy VPN Server, refer to Cisco IOS Easy VPN Server feature .
Movian VPN Client Configuration
Cisco 7200 VPN Router Configuration
The following commands show how to configure the router for this sample configuration.
Verifying the Results
This section provides information you can use to confirm that your configuration is working properly.
To verify the VPN connectivity, follow these steps.
Step 1. Login to the Hub router.
Step 2. Using the Movian tools menu, ping www.cisco.com and other intranet hosts.
Step 3. Using Internet Explorer, connect to the intranet and Internet servers.
Step 4. Make sure to reload the web page to avoid redisplay from the cache memory.
Troubleshooting the Configuration
Certain show commands are supported by the Output Interpreter Tool (registered customers only), which analyzes show command output.
Note: Before issuing debug commands, see Important Information about Debug Commands .
- debug crypto isakmp—Displays errors during Phase 1.
- debug crypto ipsec—Displays errors during Phase 2.
- debug crypto engine—Displays information from the crypto engine.
- debug ip your routing protocol—Displays information about routing transactions of your routing protocol.
- clear crypto connection connection-id [slot | rsm | vip]—Terminates an encrypted session currently in progress. Encrypted sessions normally terminate when the session times out. Use the show crypto cisco connections command to see the connection-id value.
- clear crypto isakmp—Clears the Phase 1 security associations.
- clear crypto sa—Clears the Phase 2 security associations.
Related Information
An Introduction to IP Security (IPsec) Encryption
Cisco IOS Easy VPN Client Feature
Configuring IPsec Network Security
Configuring Internet Key Exchange Security Protocol
Command Lookup Tool (registered customers only)
Technical Support - Cisco Systems


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Traffic, We've Got Your Number – It's 511
Southern California 511, a free traveler information service accessible by phone and online, launched in June. Now, you can be your own traffic reporter!
[Click on photos to read captions.]
If you have a computer or a phone, you never have to be stuck in traffic again. Alright, never might be going too far, but your life as a traveler in Southern California just got a whole lot easier thanks to the launch of Southern California 511 on June 10.
Southern California 511 is a free phone number and website (go511.com) that provides traffic, transit and commuter information to travelers in Los Angeles, Ventura and Orange counties. (Bike riders, there's even info for you!) The system is sponsored by the Los Angles County Service Authority for Freeway Emergencies in partnership with Caltrans, the Los Angeles County Metropolitan Transportation Authority (Metro), the Orange County Transportation Authority, the Ventura County Transportation Commission, and the California Highway Patrol.
District 7's role in 511 is to provide real-time traffic data and road information, such as traffic speed, travel times, photos from CCTVs, and the text on changeable message signs. The data is updated every 30 seconds, so travelers get the most recent information available. No more waiting for traffic reports – you create a customized traffic report for yourself.
The kickoff event was held at Union Station, and featured speakers from the partner agencies and demos of the 511 phone service and the Go511 website. About 60 people attended.
"Over the years, Caltrans has built a comprehensive detection, surveillance and management system that collects real-time data on the freeways so the we can effectively monitor, operate and manage the system," said Deputy Director of Operations Frank Quon at the kickoff. "We're pleased to be able to contribute that data to Southern California 511."
The idea behind 511 is that accurate, reliable information empowers you to make smart transportation choices, which allows you to avoid delays and reduces congestion. Let's say, for example, you're headed to LAX. You call 511, request traffic information, and learn that the San Diego Freeway (I-405) is crawling and the Harbor Freeway (SR-110) is moving at 50 miles per hour. Chances are, you'll steer clear of I-405 and hop on SR-110.
Although similar systems are in place all over the U.S., the travel information 511 provides is particularly vital in heavily congested regions like Southern California.
"Building new freeways is not the way to beat traffic," said Metro Chairman Ara Najarian. "We don't have the money or the land. But thanks to freeway monitoring and other technology, we do have real-time information on traffic bottlenecks so we can avoid getting stuck. We can also steer commuters to carpools and vanpools."
Both the 511 phone service and website are being fine-tuned. In the coming months, new features will be added, such as accessibility on mobile devices and Spanish voice recognition. In the meantime, travelers are encouraged to use the system before and during their trips (remember: hands-free cell calls only) and leave feedback suggesting improvements.
So, the next time you're tempted to kvetch about congestion, don't complain – go 511 and outsmart traffic.
â– Listen to a 511 phone call requesting traffic info
â– Southern California 511 website: www.Go511.com
â– More about the history and function of 511:


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Films from the 1928 Cherry Carnival in Bear River and of porpoise hunting by Mi'kmaq are among those now available on a new website launched last week by the Nova Scotia Archives.
'The Way We Were: Nova Scotia in Film, 1917-1957' highlights the first four decades of amateur and professional cinematography in the province. The collection represents some of the oldest digitized film in Canada.
Visitors can explore almost 100 black-and-white home movies, full-colour travelogues, award-winning documentaries, and government-produced tourism films from around Nova Scotia through the website and complementary YouTube channel.
The Cherry Carnival footage was taken by a summer visitor to the community, but a film on hunting porpoise for oil was made by Dr. Alexander Leighton, a sociologist and summer resident at Smith's Cove who did a long-term study of the area.
A film 'The Beaver' by Leighton is also among the archives' collection.
"This project makes valuable historic film available to anyone with access to the Internet, making it an important resource for students, educators, and life-long learners," said Tourism, Culture and Heritage Minister Percy Paris.
Lois Yorke, director of public services at the archives, said 51,000 feet of film was digitized to make this resource, and visitors to the website can browse through films chronologically, by keyword, or by filmmaker.
A 'Save to iPod' button allows users to download films.
The collection is available at www.gov.ns.ca/nsarm/virtual/nsfilm/ and www.youtube.com/nsarchives/


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This is one of my favourite purple shimmers. It's just gorgeous and it also works wonderfuly as a layering polish. Must have!
Thanks for looking!
Wednesday, August 19, 2009
Claire's Magic
2 comments:
That's really a pretty deep purple on you. Love it.ReplyDelete
- nihridaAugust 19, 2009 at 4:00 PM
Thanks! I got tons of purples, but still - this one stands out.ReplyDelete
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Rachel Gardner
Rachel co-founded Food For Thought's organic gardens and horticultural therapy project in 1999, and joined the staff full time as Client Services Manager in 2001. She has also served as Deputy Executive Director since 2010. Rachel enjoys conveying Food For Thought's values of respect, compassion, and generosity when welcoming and orienting new clients to the food bank. A native New Yorker, she worked as a professional chef for 13 years in San Francisco prior to moving to west Sonoma County. Rachel is trained in nature-based healing practices, group facilitation, and conflict resolution. Her case study for her doctoral degree in clinical psychology is on AIDS-related stigma. She enjoys hiking and takes refuge in the garden and the high Sierra mountains. Proud to be among the 18,000 gay folk permitted to marry, Rachel lives within walking distance of the food bank with her wife and their feline companions.