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Skywriting -- Feb 05, 1998
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Continued from Feb 04, 1998
NO, let's NOT go to THAT story... John found himself on the stage, with his guitar. He looked out and saw all these girls, screaming... he looked beside him and paul was at the microphone singing "she's a woman" while george was right beside him, singing the harmonies. Ringo was on the drum kit, bored as ever, trying to keep the beat. From the haircuts, it looked like 1965 (or '64, john couldn't remember). "Earth to John, you got to sing that harmony," mouthed george. But then he saw something in the distance. It was Rea and she was in the crowds, staring at John. But someone was with Rea. It was...
...sunflower. she was here to save john from those screaming girls and take him away to her magic chamber up in the sky. but rea wasn't going to tolerate such behaviour, so sunflower pointed a magic stick at her and rea turned into lovely heather. john offered both arms to the angelic women, and they walked on into the golden moonlight together. but as they walked, wind started blowing harder and harder and all the trees became dead and black and all the beautiful parrots became black crows. a man appeared on a flaming pie in the sky and said, "you shall be man and two wives..." just then...
There was a brilliant flash of white light and John found himself standing in frong of a massive, ornate building, staring up at the structure's facade. A nagging feeling in the back of John's mind whispered to him that he knew this place, but he couldn't quite place how. "Where the hell am I?" he demanded, sweeping a gaze around himself to see if there was anyone at all who would answer him. But no answering voice came, so with a sigh John simply stood and waited to see what would happen next.
Suddenly John saw a familiar, dark-haired figure leaving the building. It was evening, and getting dark out so John couldn't quite see the person's face. But there was something oddly familiar in the way that this person walked and carried himself. The shadowy figure glanced up, as though he had heard a noise of some sort, and John gasped. It was Paul? But why? John could see from the other buildings in the area that he was in New York. Why was Paul here? And where were the other Beatles? What in the world was going on here? John edged a bit closer and he saw that while it was Paul, he looked a bit older, though not more than ten years. Puzzled, John started to call out to his friend, but another voice, coming from the shadows interrupted him.
"Mr. McCartney?" called the voice, timid at first, then a bit more forceful. "Mr. McCartney!" John watched, the expression on his face turning from one of curiosity to one of disbelief and finally to one of horror and rage.
The next few things that transpired seemed to happen in slow motion. Paul turned around, glancing about to see who had called out to him when several sharp, malicious explosions rang out, shattering the tranquility of the cool evening. Paul gasped, first in shock but then in agony as he fell to the pavement. John stared as his old friend dropped like a stone, scarcely believing what he had seen happen. No, this couldn't be true. This had never happened... A movement in the corner of his eye caught John's attention. Looking up, he saw a stocky, bespectacled young man, leaning casually against the building, holding a smoking gun and easily reaching to pull a book out of his pocket. He appeared not to have noticed anything amiss at all.
John stared for a moment, but a faint moan ripped him from his disbelief. Glancing down, John could clearly see Paul crumpled on the sidewalk, his breathing shallow and gasping, his face contorted with pain. Rushing to his friend, John knelt down at Paul's side. Suddenly he saw where Paul's jacket had fallen away, exposing several spreading crimson stains on the white shirt beneath. Paul's gaze was vapid; he seemed to be focusing all of his remaining energy on breathing. But all at once he glanced up to see John kneeling over him, and a faint shadow of recognition crossed Paul's face. "John?" he whispered, barely audible. "John. 's that you?"
John swallowed hard, telling himself that he was just having a very real, very strange dream. This wasn't happening. It couldn't possibly! "Yeh," he answered gruffly. "Yeah, Paul, I'm right here." Paul blinked in surprise. "What happened, John?" he asked softly, struggling to get the words out. John didn't say anything for a moment. How to explain to one of his best friends that he'd been shot? But John could only tell Paul what had happened as bluntly as he said anything else. "You've been shot, you bloody fool," he whispered, trying not to let Paul see just how worried he was. "What'd you have to go and do that for?"
suddenly lovely heather walks up with wonderwall at her side. "hey john--get up from that sidewalk. paul's not there--you've been imagining things again." john got up and shook his head of the dust and saw someone in the distance...
As the figure neared, John saw that it was Paul. Rushing up to him, John stared incredulously. Noticing the odd look crossing his friend's face, Paul grinned teasingly. "Hey, what's the matter, John? You look like you've seen a ghost or something!" John couldn't quite smile back. What was going on here? He had just seen it- Paul had been lying there bleeding just a moment ago. He couldn't have imagined it, it all seemed so real... But what could he possibly say to Paul? Tell his friend that he had just been shot? John brushed the thought away and mustered up a weak smile. "Nah," he said, shrugging. "You just startled me, that's all." Paul nodded understandingly and...
sneezed. out of his nose flew ribbons and confetti. "HAPPY BIRTHDAY JOHN!!!!!!!" paul said.
"Why thank you Paul" said John. He couldn't get that picture out of his mind. HE knew that he just had to tell Paul what he saw. He turned around and said "Paul.....
Hey!!!! wonderwall's in this story??? So Heather forgot all about John Lennon and saw David standing there, with flowers in his hand for her. They embraced and kissed and then Heather took him back into a bedroom and proceeded to.....
"did i self self-involved?" john growled "i mean self-indulgent. all these people trying to weave themselves into the story without giving it love, without giving it a heart, without making any bloody sense. why can't they just come together and let me speak through them?" he put his head in his hands. "your time is short." yoko said, tenderly stroking the top of john's head. "you just have to hope that they figure it out soon." john looked up, his hair hanging in his face, his eyes filled with tears....
Suddenly John leapt up and yelled "hey this is crazy!" "what is John?" Yoko lo9oked worried "everyone's making me have a bad time in this story and i'm sick of it! I'm phoning the Beatles, Mick, Keith, Noel and the rest of em, we're all going for a wild night out!" "wild nights out are great for relief of stress and tension" Yoko said "I'm with you" Some time later a car pulled up, "ey John!" Noel's voice shouted out "that's them let's go!" John and Yoko got in the car with Mick, Keith, Noel and various other top rockers aand drove off, the sounds of rock'n'roll balring through the car stereo
"Bad time or not, John...it's reality." "What's reality? Paul being dead? Paul's dead?" His face twisted in disbelief. He looked up to what should have been the sky. He couldn't see the sky. He saw stone. Dark Grey stone.
He heard voices in his head. He heard Keith Moon, good old Baron Von Moon telling him another sip wouldn't hurt..Where's my necklace, John? May had invaded his head. Something was symbolic about that. May. That name didn't mean anything. Fung Ye. Phoenix bird. Rises from death and ashes to live another life. Come on, John...one more drink, then we'll go home...one more sip...now don't get loud....don't wanna get tossed out, do ya?
"What do you mean by 'you'll try to save me'?" John thought aloud. All eyes turned to him. He stood in La Fortuna Cafe on the West Side. "shhh...John...sit down.." He looked down to the table and saw the newspapers covering it. Paul's name in all the headlines. "What's this about, Mother?" He stroked the bit of newspaper until the newsprint came off on his hand, obscuring McCartney's face. He saw himself in the window. He looked like a madman. He hair stood on end, uncombed. There were dark hollows beneath his eyes. Shit, he thought. I look like a junkie. I'm a freakin' junkie again. "I know it's hard, John...but people are staring" He sipped his coffee slowly. He hadn't changed his clothes from the night before. His red tee-shirt stuck to his back beneath both his old blue sweater and black leather jacket. Bleary eyed, he tried to focus on the image of himself. He didn't remember looking that way. He barely remembered ever feeling that way. "Have I been..?" "Crying? Yes." He'd rubbed his eyes nearly raw. He replaced his thick, plastic framed glasses.
john realised that the picture wasn't the present him but the past. he was looking into the past agian.
Dammit...voices in my head...the voices won't shirrup!
Suddenly Noel Gallagher popped up on TV.He announced the opening of the new Allaroundtheworld long distance corporation.Somehow the operators were replaced by evil blue meanies. They disconnected Noel's line now noone can ever hear him call.Somehow Coca-cola was hiring the meanies it was all some conspiracy about "Shakermaker".Suddenly John looked up and put on his glasses got in his psychedellic rolls along with yoko to help restore the first phone company run by a rock band influenced by the Beatles.They went...
The past was a safer place. But he had a feeling that Sally wouldn't let him stay there for very long. The past is always a comfort because you know what happens, even if it isn't happy. It was like seeing "On the Waterfront" for the umpteenth time. You knew what happend to Marlon Brando. You knew who won and who lost. You knew the Nazis lost World War Two. Didn't they?
Yes they did but anyways Liam was standing in the shadows, shooting some coke when finally someone nudged him and told him it was his turn. He gaily skipped to Lennon's side and said "Hey mate I'm going to join your band." Lennon said "That's groovy. Where's McCartney?" Liam replied laughingly "I bashed him with me booze." Both fell over laughing, linked arms and walked into the sunset to the nearest bar, each with a groupie on one arm. This was the beginning of a beautiful friendship.
Of course they did...of course..that was the way things were supposed to be. Everything was supposed to be normal. He hadn't seen those hallucinations in years. He used to have them when he was younger. He could close his eyes and press his thumbs against the lids to make those dazzling arrays of colour. The harder he pressed, the wilder they would become. Until he opened his eyes and saw everything outlined, more clearly than it ever could have been. When he closed them again, it felt like he'd been staring at the sun at noon.
Paul grinned at John over a glass of white wine. "You're still as daft as you used to be, John..you think you can hide forever in your little fort..I'll tell you, though..moats don't work anymore." Damn you, McCartney. All your sarcasm, all your little put-downs. At least I was bold enough to say them out loud!
no, that was liam who said that. he never had any brains and never will.
"Who is this Liam?" John thought the words. Liam who this is? Is who this Liam..Liam, is this who..? He sighed angrily. His supposed madness was worsening. The sky was blue. The grass was brown. But the people were photographic negatives. White eyes in pitch black faces. Black teeth in white mouths. Liam sneered, playing off his bewildered state. "Wot's a matter, Lennon...you some kinda cripple?"
but then Paul decked Liam, completely knocked him on his ass. "Wot you do that for, ya wank?" cried Liam as blood spurted from his nose. "Because you dogged Dr. Winston, that's why. Now bug off!" and Liam scrambled to his feet so he could run like hell. "Well done, friend!" cried John. And the two of them walked off to find Ringo and George.
They found Ringo with his hand stuck in a vending machine. "I thought she was a sandwich," he mumbled. "She?" asked John and Paul in unison. "Yeah. The bird with the blue feathers," replied Ringo. They looked into the little glass window and saw...
The pavement dipped before them. "Pa-aul...How 'er we gonna find them here?" Paul looked at him. "Why wouldn't we find them here? We're all playing at the Indra. John...What has that woman put in yer pills?" He looked at John's eyes, a slightly odd family physician. "But it's New Yor-" It wasn't. There was no familliar park. It was Hamburg again. "Prelly's must be gettin' to ya...The Hurricanes are on right now...we could catch the end of their act...
Paul looked around and saw all the familliar Hamburg shops, the whores and the bars. He suddenly felt like a stranger. John saw the look of alienation in Paul's eyes, but chose to keep quiet. Ringo was still mumbling about birds and sandwiches, so he hadn't noticed yet. Then George came walking up to them, with his girlfriend and another chick. The "other chick" was the strange girl from the party. Paul shouted "look! it's that Miranda girl! wait... you never called me. What the hell is that all about?"
John shook his head and closed his eyes. "What's wrong with me?" he muttered for the millionth time. "John." At the sound of his name, John looked up to see a new grrl, one with pity in her eyes. "John," she said again. "I know this dream is getting terrible, but it can't last much longer." She quietly hugged him and he tried to rest his head for just a moment of peace.
"It is really a dream, Love?...Make it a dream..." He was afraid. For the first time, he was afraid. His knees trembled in fear, his stomach turned. "I want it all to be a dream. I want to wake up and see the sky again." In the other reality, Yoko pressed his hand tenderly. John felt her touch. God...It's cold in here... The woman with sorrowful eyes brushed his hair back gently.
Paul looked at John shivering. Then he looked at Miranda, who was walking toward where John was laying. She pulled a tye-dye hankerchief out of the pocket of her purple dress and folded it into a triangle. She put the triangle on John's forehead and he jumped up, smiling. "How the hell did you do that?" he asked Miranda. "I learned it in the Girl Scouts," she said with a shrug. Paul ran over and hugged her. "You helped John out of his bad dream. Thanks ever so much," he said. Then he kissed her warmly, forgetting Jane and Linda and the strange girl whose ass he had been squeezing earlier... he forgot everything except Miranda...
John, however happy he seemed, was still torn inside. What did all this mean. Why did he have to be saved? why would everything be over soon?
so-o-o... to celebrate john's miraculous recovery, the five of them (john, yoko, the new girl, paul and miranda) all hunted down ringo and george. the seven went out to find some pies. paul and miranda ate a honey pie, john, yoko, and the new girl (whose name was susan) shared a grapefruit pie, and george ate a jellybaby pie. ringo couldn't decide which pie he wanted, so he went across the street and bought a pizza pie.
after eating his pie, John felt a thousand times better. He left with susan and yoko to go for a walk, while paul and miranda made "puppy eyes" across the diner table...
John once again walked with the spring in his step. Bounding ahead, as though called. He began to run- as he had not done since he was a boy at grammar school. He rain faster, letting the wind whip through his hair. His legs began to feel numb and he stopped to catch his breath. The world spun at full tilt.
As h stopped, he listened to a voice, singing some unknown tune: "will you remember, will you recall? I won't remember the things that we swore, I won't remember your name, I won't remember the future we planned, I'll just love you as then.", she sang, busy looking to the ground. "What are you searchin for?", John asked. "My glases....I think I lost them. Would you help me, sir?" She didn't recognize him, so he started to search the woman's glasses too.
"You have a very nice voice", she said. "I heard you singing once. But it's a pity that I don't like rock and roll as I supposed to." . John just stared. That girl was pretty and had a voice that sounded like the wind coming thru the woods. "I'll teach you a song. So when you want to be free of those scary trips, you can hold on it.."
She sat down, and started: "Half of what I say is meaningless...but I say it, just to reach you...." And then...the voice dispapeared...like a whispered song.
"Who are you? Better yet, where are you?", John shouted. Just as he was asking it, some laugh cut thru him. A very known laugh. "See, you fool? The girl with the sky in her eyes..." "Sally was it just a dream?" "I am the piper at the gates of dawn. All I touch is a dream. But tha girl, Johnny she was real. Seek and ye shall find! Ciao, bello!"
"The girl, Sal! Who was she? Who is she? Looking for her glasses? Mother?"
Sally ran away from him, almost not touching the ground. John ran after her - but that was a hard thing to do, follow Sally Townshend-Barret, the piper at the gates of dawn. You could take an inch, she'd run two miles. When he finally gave up of running after her, he heard her voice shouting: "SEEK AND YE SHALL FIND...SING, YOU BLOODY FOOL, IF YOU WANT TO FIND! SING THE SONG SHE WAS SINGING...if you remmeber it of course."
MEANWHILE... Linda and Paul and the other girl walked around town. Paul and the other girl went to the store to see something, while Linda went to some art shop. BUT OHMIGOD! she was transported to a planet called Mos Eisley. "where am i?" said Linda. she looked around, and there next to her was John! "john! what are you doing here?!" exclaimed linda. "i dunno, linda.. but i've got a bad feeling bout it" said John. then 5 girls came out of the shadows. It was Tenel Ka, Francie, Anna of the Field, Cyn and G!!! Linda groaned. "what are you GUYS doing here in this part of the story?!?! it is suppose to be SERIOUS. you have ruined it!!". Francie spoke up, "well we were bored and we wanted to feed you and john to the monkeys in the zoo at Sao Paolo!! HAHAHHAHA" will our heroes be DOOMED?
Remember? Remember? John was panicking. The song! The song, what was the song...the song she was singing...Sally please help me, for once in your life help me to get out of a pothole! Sally? Sally? Damn, Sally Barret, help! HELP! I WANT TO REMEMBER! The bird with the sky in her eyes....God how I wish this was just one scary trip! Sally? Where am I?
"Oh Lord, if you excuse me... it seems someone is calling me.", Anna said, leaving fast. It was a guy in black clothing and top hat. "What's the fuss, Bruno?". "Like that, Annie dearie. Remember Sally Barret?' "Yep. So what?" "I think your friend John is seeking for her." She laughed. "She's the piper at the gates of dawn. If he wants to find her, he just need to dream. If you excuse, Bruno, I still have a monkey business to solve. Tchau." And she turned to her friends. "well, so what? Do we catch the plane?"
then a voice came. "Don't worry John and Linda baby! I'll save you!!" who was it? out of the door came Austin Powers wih Ms. Kensington. "oh no.. not YOU again!" moaned Linda. "we ARE doomed, Linda," said John sadly.
then out of the shadows (we have a lot of shadows in this story!) Sally came, wearing her little peter pan-ish outfit. "realease the hostages you dim-wits!!", screamed Sally. "or what?" said Francie sarcastically. I'll bring someone to help me out!" threatened Sally. "who?" said Tenel Ka. "XENA! warrior princess!!" said Sally. all the girls got scared. Xena was some mean green fighting machine!
"Yep you are.", Anna looked. "With a hero like THAT you don't need any enemy!" and, she started to sing in a very mocky voice: "I won't remember the things we swore and won't remember your name I won't remember the future we planned...". John looked to the brazilian. "Sally? Damn, it was you all the time, Anna? "
She laughed, and her laughter sounded like Sally's.
"Oh, greeat", John thought. "Now I find out that Sally is at their side too. I am already seeing meself at some end of the world's zoo". Just by then he realised that Anna - or Sally, or whoever she was - was laughing. And he knew that everytime she laughed something was about to happen. "Let me take you back, John..........." she called.
"Back to WHERE?", he shouted. "To where it all began, where else?". "Liverpool?" "No. I meant where you began to live. Really live. C'mon. Don't ask me no questions. Just follow me thru the gate...". And he did. But as she passed to the Dawn, the gate closed with the mightest crash. John was locked inside the middle-of-the-way. Again on his own. "Seek...and ye shall find. Ciao!"
Back to feed the monkeys!!! Linda and John were lowed into a pit, with this snarling wild genetically improved violent monkeys. but then john looked closer at the monkeys. it was the BAND the MONKEES!!!! OH NO...
"Linda? since this is our last moment on earth, i have a favour to ask you," said john nervously for they could already feel micky grabbing their feet. "What, John?, said linda. "can you kiss me? one for the road?, " pleaded John.
He stopped himself. He never wanted to kiss Linda. He almost remembered the song. But the words slipped though his mind like sand through an hourglass. "I don't remember...I don't know anymore!"
And Noel, realizing that Heather would *thank the lord* never be right for him, left her, vanishing her to the world of the boring self-indulgent people, where the spice girls were big. John Paul George and Ringo all rejoiced.. YIPPEE! they said. Then Noel walked off to Meg Matthews, his real true date.. When suddenly, Paul realized that his pants were down..
So Paul and his bare ass were hauled off to Attica State where hairy guys named "Bubba" beat the crap outta him.
So hey won't someone please buy me a beer? I just can't find a bottle anywhere. You know my head's so foggy and I can't see clear. I wish somebody would buy me a beer.
But then George, who is after all the real hero of this story, arrived at the prison and rescued Paul in his magical flying formula one racing car, courageusly beating off all the evil Bubbas and taking Paul back to Friar Park, where he forced him to listen to Ravi Shankar records till his ears bled.
John's hands shook. He wanted a beer. No, needed it. He needed somthing to steady his hands. A cigarette...a drink...a woman.. Stu, Stu...you could always talk me down...where the Hell are ya now? I need you..I need you so bad...Please..answer me..speak to me...show me an answer... He saw white halls. White linoleum halls that smelled like disinfectant. Hospital smell. He hated the smell of hospital. Cold whit house of death in all its macabre glory.
John woke up in a cold sweat. A cool breeze was wafting through the window from the darkness outside. It had been a dream. He didn't need a beer. He lay there in the dark for a few minutes, remembering where he was. He was at the Radisson Hotel in the VIP suite with the other Beatles in seperate rooms. Just then, he heard some strange noises out in the lounge (it was a very big suite) He could hear someone's voice - Pauls? - saying something. He sounded disturbed. John jumped out of bed and quickly opened the door to find...
Paul and Ringo dressed in black. They moved about the lounge in the dark. They didn't notice John peeking at them through the door. They began going through his suitcases. John heard Paul mutter that they had to get a hold of the naked pictures of John and Yoko before they were sent off. He couldn't risk John damaging the bands reputation by flashing his Mr. Winky of the cover of an album.Ringo was his accomplice and together they vowed to find the naked pictures. Of course, Ringo would get a sizable reward from Paul for helping. Paul told him that they were doing no harm, the bands reputation was at stake. John continued to look through the door in disbelief...
"Reputation, Shmeputation. I'll show them", he thought. Making everyone shake in their narrow tipped half boots could be a blast, naked pictures or not. This sounds like a job for the International Man of Mystery. If he can't hide the film nobody can. Not even that Magical Mystery Tour should fing a clue.
then he became a bird an fly trhu his mind till he realixe he still a dreamer.
he tried to stay calm, looks everything and seehg empty, every face every record every song that remains him the beatles legacy was empty, empty and fake as paul... there was no walrus there was no sun king,theres was no beatles... only memories... then realize that life is full of magic full of dreams ,so full of LOVE. Thats all we need love ,we dont need beatles we dont need lennon, mcnarneys,harrison,stars, we dont need maharishis we dont need heros we dont need drugs... ALL I NEED IS LOVE>>> ALL WE NEED IS LOVE>>> LOVE>>>>>THATS THE WORD>>>
Continued on Feb 06, 1998
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The FBI Career Guide: Inside Information on Getting Chosen for and Succeeding in One of the Toughest, Most Prestigious Jobs in the World
The FBI Career Guide: Inside Information on Getting Chosen for and Succeeding in One of the Toughest, Most Prestigious Jobs in the World
"In the three years following the September 11th, 2001, terrorist attacks, the Federal Bureau of Investigation hired 2,200 new Special Agents. But that was out of more than 150,000 applicants, and you can be sure the successful candidates had not only relevant backgrounds, but also determination and a genuine desire to embark on one of the most coveted, rewarding, and challenging careers in the world. The FBI Career Guide spells out exactly what the Bureau is looking for in Special Agent candidates, and how to maximize your chances of being selected from the huge applicant pool. Joe Koletar, whose own blue-ribbon career at the Bureau is second to none, shows how to get the job-and how to thrive once you've got it. His inside look at the
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Caddie Confidential: Inside Stories from the Caddies of the PGA Tour
Caddie Confidential: Inside Stories from the Caddies of the PGA Tour
"Nobody knows the game of golf like a caddie. The caddie sees it all: the unrelenting dreams, jaw-dropping victories, and soul-crushing defeats. They rarely receive credit when things go right and frequently take the blame when things go wrong, yet they are the invisible backbone of the game. Behind every top-10 finish, every Tour championship, and every missed cut there is a guy pulling clubs for his pro. "He is part-time meteorologist, part-time mathematician, and full-time therapist. He will deftly predict wind conditions; ensure that a superstitious player always has his lucky penny, nickel, or dime in his pocket before hitting the links; reserve unlucky No. 4 balls for pro-ams only; understand how the grass condition and growth pat
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DALLAS -- With Super Bowl XLV now roughly four days from kickoff, the Green Bay Packers and Pittsburgh Steelers issued their first injury reports of the week Wednesday.
Steelers Pro Bowl C Maurkice Pouncey, whose high ankle sprain has been the most scrutinized ailment of the week, did not practice today. He was originally injured in the AFC Championship Game win vs. the New York Jets. DE Aaron Smith, out since Oct. 24 with a torn triceps, was officially limited. The buzz around town during the week is that neither man will play Sunday.
"He's a center who's got a high ankle sprain,'' Steelers coach Mike Tomlin said after practice. "If he played a skill position, we wouldn't be having this conversation. But he's an interior lineman. Whether he practices depends how he responds to treatment.''
Packers T Chad Clifton (knees), C Jason Spitz (calf) and LB Erik Walden (ankle) were limited, though all expect to be available for the game. Clifton and Walden are both starters.
Green Bay rookie LB Frank Zombo practiced fully even though he hasn't played since Week 14 because of a knee injury. Walden has since replaced him in the lineup.
Nate Davis is a reporter, blogger and editor who's been at USA TODAY since 2000. He has covered the NFL since 2005. No, he did not play quarterback for Ball State. Davis' succession of our esteemed colleague Sean Leahy at The Huddle is considered a Brady-for-Bledsoe swap by most "insiders."More about Nate


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The arch-conservative Supreme Court justice is quoted in this Jonathan Alter column as saying that banning flag-burning would "[dilute] the very freedom that makes this emblem so revered.?
Mr. President, when you find yourself to the right of Antonin Scalia, you've crossed over into crazy town.
The flag-burning amendment, which already passed the House, is apparently just short of the 67 needed in the Senate. With one or two absences, the amendment would be approved. It would then go to the states for ratification, where its chances for approval appear good.
On the Republican side, all senators except Robert Bennett of Utah, Lincoln Chafee of Rhode Island and Mitch McConnell of Kentucky favor the amendment. The rest (including those who should know better, like John McCain and Chuck Hagel) are apparently in favor of trivializing the document they swore to uphold. Banning flag burning, in the words of Justice Antonin Scalia, ?dilutes the very freedom that makes this emblem so revered.?
From koce.org
Supreme Court Justice Antonin Scalia


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This season, Kitsuné Tee sojourns to American shores for a vibrant, pop art-heavy collection of printed T-shirts. Of note for Spring/Summer 2013 is a trio of garments inspired by the most American of foods — hot dogs, burgers and pizza — each one providing humorous, continental takes on classic American icons. Elsewhere in the collection is Kitsuné's latest collaboration with André — featuring the artist's own spin on the USA theme — while the French label shows it hasn't forgotten its roots with new iterations of the Parisien and Fox Ears graphics in bolder, updated colors for spring.
Kitsuné Tee's Spring/Summer 2013 T-shirt collection is available now at our online store.


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Strong and immediate backlash from the peanut gallery.
Apple (Nasdaq:AAPL) is under fire from all sides after yesterday's iPhone 5C and 5S reveal. Enterprises are unhappy, consumers are disappointed: The platform is still too closed and even the "cheap" device is too expensive. No wonder the stock took a pounding yesterday.
In IT Blogwatch, bloggers look elsewhere for mobile leadership (and not just to Android).
Your humble blogwatcher curated these bloggy bits for your entertainment.
Martyn Williams goes hands-on (briefly):
One of the big new features on the iPhone 5S is the [Touch ID] fingerprint sensor. It's embedded into the home button. ... [It] should make it faster and easier to get into your home screen while keeping it secure.
...The new flagship of the iPhone range comes with...performance enhancements, according to Apple [and] longer battery life. ...difficult to test in the limited time I had. MORE
But surely Touch ID is good for the enterprise, right? Antone Gonsalves says "No":
Many businesses would welcome a reliable fingerprint scanner. ... Unfortunately, Apple is likely to disappoint. [It] was silent on whether the scanner could be used for third-party software. ... Apple's track record with companies is not encouraging.
...Apple is providing a bunch of enterprise-pleasing security features in iOS 7. ... But the scanner remains off limits, and that's unlikely to change anytime soon. MORE
Even Jonny Evans isn't pleased with the 5C schtick:
$100 cheaper with a contract...doesn't deliver on the expectation. ... Just look at the cost of the unlocked models. ... I don't think this will be enough to worry Android device makers playing in the upper mid-range of the market. ...now users have a..."Choice". Wonderful. Except -- users already have a choice: Apple, or [Android].
Has Apple crawled up its own navel? [Its] classic sales pattern...has seen Apple lose momentum in comparison to the Android massive. ... That's bad news....
The iPhone 5C becomes the brand for "choice", while the iPhone 5S remains the brand for innovation. ... This would have been a great idea. Last year. MORE
G'day, Paleoflatus do you think it's a dag?
Apple used to be innovative, but, like most ageing corporations, they're now playing catch-up. ... 5S is almost as good as an HTC One, or a waterproof S4, apart from its dated look and its small screen.
...A fool and his money are soon parted - and there's no shortage of those. MORE
Steven J. Vaughan-Nichols says the true smartphone giant is Microsoft (yes, you read that right):
Oh please, get over yourself. ... Apple will never, ever get to the top of the smartphone heap again.
...Microsoft is number one with a bullet...because it profits from Android-related patents. ... Life can be very profitable for a patent troll. ... Earlier this year, the estimate was that Microsoft would make $3.4 billion from Android. ... Thanks to its recently acquired Nokia design patents, Microsoft can also be expected to hit up smartphone vendors for more. MORE
Unsurprisingly Preston Gralla agrees:
Its technologies power a majority of smartphones today and it's reaping billions of dollars annually from it. ... Companies that make other Android-based devices do as well, such as Nikon.
...How much money is involved? Just for smartphones, plenty. ... By 2017, if you use IDC's numbers for expected shipments of Android phones, [it] will grow to $5.5 billion. ... Other estimates say that Microsoft could get...$8.8 billion by 2017. MORE
Meanwhile, "God" has, errr... a book to sell:
Already got My new iPhone 5s. Got it from Steve Jobs himself.
#itsgoodtoknowpeople MORE
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Subscribe now to the Blogs Newsletter for a daily summary of the most recent and relevant blog posts at Computerworld.


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Nuoc Ngap Mine, Luc Yen, Yenbai Province (Yen Bai Province), Vietnam
This page is currently not sponsored. Click here to sponsor this page.
Mineral List
10 entries listed. 8 valid minerals.
The above list contains all mineral locality references listed on mindat.org. This does not claim to be a complete list. If you know of more minerals from this site, please register so you can add to our database. This locality information is for reference purposes only. You should never attempt to visit any sites listed in mindat.org without first ensuring that you have the permission of the land and/or mineral rights holders for access and that you are aware of all safety precautions necessary.
Garnier, V., Giuliani, G., Ohnenstetter, D., Fallick, A.E., Dubessy, J., Banks, D., Vinh, H.Q., Lhomme, T., Maluski, H., Pêcher, A., Bakhsh, K.A., Long, P.V., Trinh, P.T., and Schwarz, D. (2008): Marble-hosted ruby deposits from Central and Southeast Asia: Towards a new genetic model. Ore Geology Reviews 34, 169-191.


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LEBANON JUNCTION - A Bullitt County man was recently found guilty of manufacturing methamphetamine.
A Bullitt Circuit jury found Jason Argenbright of Lebanon Junction guilty of manufacturing methamphetamine in October 2009.
According to testimony delivered by members of the Bullitt County Drug Task Force, a meth lab was found in a garage outside the residence Argenbright was living in.
SHEPHERDSVILLE - Walter Sholar has told the tale about his high school dream of serving as county attorney.
That has been accomplished over the past 21 years. But he also realized a bigger dream - to be an attorney.
As his days as county attorney come to an end after five terms, Sholar is ready to embark on his real passion of helping people.
SHEPHERDSVILLE - While disappointed with the defeat at the polls, Sherman Tinnell said he is proud the accomplishments made over the past four years as mayor.
"It was a learning experience," Tinnell said of his second term as Shepherdsville mayor. "Things had really changed in government."
Serving a five-year term in the mid-1990s, Tinnell had his share of excitement, including snowstorms and the flood of 1997.
NICHOLS - On Monday, the theft case against former Nichols Fire board chairman and treasurer James Johnson Jr. was sent to the Bullitt County Grand Jury.
The next evening, members of the Nichols Fire District board of trustees were taking steps to get a tighter control over the finances.
Johnson, the long-time chairman of the fire district board and treasurer for the district, was arrested recently and faces a felony charge of theft by unlawful taking over $10,000.
SHEPHERDSVILLE - After handing out business cards and shaking hands with anyone within arm's length the past 12 years, the question is a simple one.
SHEPHERDSVILLE - Despite the lack of assistance through the federal stimulus incentives, the Shepherdsville-Bullitt County Tourist and Convention Commission is moving forward with the expansion of its showcase facility.
A local man sustained relatively minor injuries after crashing a black Ford Mustang into a telephone pole on Cedar Grove Road Monday morning.
When Shepherdsville fire and police units arrived on the scene in the 400 block of Cedar Grove Road near I-65 around 9:40 a.m. the car was found totaled with the driver lodged inside.
Cpt. Matt Smothers of the Shepherdsville Fire Department said firefighters had to remove the driver-side door to extricate the victim.
SHEPHERDSVILLE - Magistrate Buddy Shepherd may have wanted to give a little extra Christmas gift to all in Bullitt County who paid insurance premiums.
The Bullitt County Health Department warned that Wal-Mart is recalling over two million electric heaters.
The store placed a recall on 1,500-watt heaters with the product names of 'Flow Pro', 'Airtech', 'Aloha Breeze' and 'Comfort Essentials'.
Malfunctions in the heaters may result in overheating, causing fires or melting.
The Health Department warned consumers to stop using the heaters immediately and return them to Wal-Mart for a refund.
MOUNT WASHINGTON - A mother has been charged with causing serious injuries to her 2-year-old son.
Copyright © 2017
The Pioneer News Online is your source for local news, sports, events and information in Bullitt County and Shepherdsville, KY, and the surrounding area.


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U.S. diplomatic posts are now closed in the Muslim world because of potential terror threats. Why today? It's the 27th day of Ramadan, when the first verses of the Koran were revealed to the Prophet Mohammed, says Peter Bergen, a journalist who has written extensively on al-Qaida and interviewed Osama bin Laden in 1997.
It's considered by Muslims to be "the night of power," and by "would-be martyrs as a particularly auspicious day to die," Bergen writes on cnn.com.
In 2000, when it fell on January 3, al-Qaida tried but failed to attack the USS The Sullivans off Yemen. Ten months later, they hit the USS Cole, killing 17 sailors and injuring 39.


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Seven life sciences companies received up to $200,000 each from the state government through the state's BioMaryland Center.
Here are the seven grant recipients and their respective projects, from the press release:
- AsclepiX Therapeutics, LLC (Baltimore): a long-lasting drug which would reduce the number of eye injections for macular degeneration and improve patient vision.
- Brain Sentry, Inc. (Bethesda): helmet mounted sensors which detect and count possible concussive injury hits for youth engaged in sports.
- Clear Guide Medical (Baltimore): ultrasound guided technology to make needle biopsy more accurate, faster, and safer.
- Cordex Systems, Inc. (Annapolis): an enhanced blood pressure cuff to measure endothelial dysfunction, the earliest indicator of atherosclerosis.
- Harpoon Medical Inc. (Stevensville): a surgical tool which will enable surgeons to reliably repair the mitral valve using a minimally invasive beating-heart approach.
- Otomagnetics (College Park): a magnetic particle drug delivery system for treatment of sudden hearing loss and eventually common ear infections.
- Vasoptic Medical Inc. (Columbia): a low-cost portable retinal imaging instrument for early diagnosis of diabetic retinopathy affecting 1 in 3 diabetics.
- Johns Hopkins University (Baltimore): a system which assists with securing the puncture site during cardiac ablation therapy to compensate for the beating heart.


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Should You Have to Have a Photo ID to Vote? — Survey of the Day
As of now, 17 states have laws requiring voters to present photo ID before voting. Some have suggested these regulations may act to disenfranchise poor and minority voters, who could be less likely to have such identification. Last month a judge in Pennsylvania blocked the state from enforcing its voter ID laws in the 2012 election.
South Carolina and Kentucky Ban Booze on Election Day
An election is the ultimate celebration of democracy. However if you live in South Carolina or Kentucky, booze probably isn't going to be part of your November 6 revelry.
Are You Voting Early in This Year's Election? — Survey of the Day
10 Costumed Mugshots for Halloween
How Much Are You Planning to Spend on Halloween? — Survey of the Day
Halloween Costumed Girl Shot By Relative Who Mistook Her For a Skunk
It's unclear if a nine-year-old New Sewickley, PA, girl was actually dressed as a skunk Saturday night for a local Halloween party.
But she was wearing a black hat and a white tussle and that was enough for a relative of the unidentified girl to mistake her for the stinky varmint.
Bill Murray Makes Kickball Game 100% More Awesome
Bill Murray is known for having a good time at sporting events. The funnyman is always the highlight of the annual Pebble Beach Golf Tournament and his antics at Wrigley Field are the best thing that's happened to the Chicago Cubs in years. So it's little surprise that he'd show up at a pick-up kickball.
Man Reunited With Car Two Years After Forgetting Where He Parked It
Forgetting where you parked your car always gives you a sinking feeling. However, it may have been for the best that this German man lost track of where he'd left his vehicle in December of 2010...
Do You Want a Facebook 'Want' Button?
Chef Uses Cheese Balls to Teach Food-Flipping Skills
One the questions Chef John of Food Wishes is asked most frequently: how do chefs manage to flip food in a pan? Eventually he decided to film a video for all of us slobs, revealing (with low-stakes snack food) how the pros do it.
Have You Ever Been Confused by Text Message Abbreviations? — Survey of the Day
Worst 'Price Is Right' Contestant Ever Just Can't Come Up With Showcase Showdown Bid
At the end of every episode of 'The Price Is Right' the two remaining contestants bid on respective "showcases" of prizes, with the winner being the one who gets closest to the prizes' actual price without going over.
It's a simple enough concept, but on a recent episode a contestant named Mary got pretty tripped up by it.


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Game Ninety-Six: Cubs 3, Diamondbacks 9
WP – Wade Miley (6-6) LP – Travis Wood (7-9) Save – None
For the second straight night, the Cubs jumped out to an early lead and for the second game in a row the Cubs ended up losing a game in the desert. The Cubs had a 3-1 lead as late as the fifth inning before Travis Wood lost his command and gave up four runs in the fifth. The big hit was a bases loaded double by Miguel Montero. Paul Goldschmidt added the exclamation point, a two-run homer in the eighth.
The Cubs dropped their fourth game in a row and have lost 10 of 12.
Travis Wood had another rough outing and struggled with his command. And while he received no help from his defense, Wood had trouble throwing strikes. Wood was consistently behind in the count and appeared to be battling himself throughout his outing. Wood made gestures to remind himself about his mechanics and was talking to himself on the mound.
Travis Wood was charged with seven runs, five earned, on eight hits with four walks and three strikeouts. One of Wood's three strikeouts was on a failed bunt attempt by Wade Miley. Wood issued four walks and two of the free passes scored in the fifth inning. Wood threw 98 pitches, 63 for strikes, in 5 1/3 innings.
Carlos Villanueva kept Arizona off the board for 1 2/3 innings, but Zac Rosscup could not record the third out in the eighth before he gave up two more runs. Rosscup allowed Aaron Hill to reach on a two-out double and Paul Goldschmidt smacked a two-run homer.
The offense had chances early in the game to put runs on the board against Wade Miley, but the Cubs could not come up with the hit with runners in scoring position.
Starlin Castro (2-for-4 with a RBI) drove in Justin Ruggiano (1-for-4 with a run scored) with a single in the first inning. Welington Castillo (2-for-4 with a home run) gave the Cubs a 2-1 lead in the fourth inning with his seventh longball of the season. And Mike Olt (0-for-3 with a sac fly RBI) plated Junior Lake (1-for-3 with a triple and a run scored) with a sac fly in the fourth.
Darwin Barney (2-for-4 with a triple) and Anthony Rizzo (1-for-3 with a HBP) reached base twice. The Cubs pounded out 10 hits but were 1-for-8 with RISP and left seven men on base.
The Cubs defense was only charged with two errors (Alcantara and Olt), but the defense made several other miscues Saturday night. Welington Castillo, Mike Olt, Arismendy Alcantara, Chris Coghlan and Starlin Castro had rough games in the field.
With Saturday's loss, the Cubs dropped to a season-low 16 games under .500 with a 40-56 record.
The Cubs squared up Wade Miley in the first inning, but managed only one run after another excellent catch from Ender Inciarte. Alcantara struck out swinging to start the game. Justin Ruggiano followed with a single to right (1-2 pitch) and went to third on a single to right center off the bat of Anthony Rizzo. Starlin Castro singled to center, Ruggiano scored and the Cubs took a 1-0 lead. Welington Castillo hit a deep drive to center that Inciarte ran back and made a leading catch at the wall. Inciarte robbed Castillo of at least a double and he kept the Cubs from scoring a pair of runs. Rizzo tagged and went to third. Lake flied out to right center to end the inning. The Cubs made Wade Miley work (23 pitches, 14 for strikes), but Inciarte changed the inning.
Travis Wood struggled with his command in the first inning but was able to wiggle his way out of a bases loaded jam when Martin Prado flied out to right center to end the inning. Wood really labored in the first inning (27 pitches, 16 for strikes).
The Cubs led 1-0 after one inning.
The game remained 1-0 Cubs until the bottom of the third inning. After Wood retired Hill with a flyout to right, Paul Goldschmidt singled to center. Mark Trumbo flied out to right center. Wood could not retire the lefty-hitting Montero and the D-Backs catcher ripped a single into center. The ball hit off the heel of Alcantara's glove and bounced past him. Goldschmidt was running with the pitch and when Alcantara did not field the ball cleanly, Goldschmidt was waived in. Goldschmidt scored when Castro's throw to the plate pulled Castillo too far up the third baseline … game tied at one. Martin Prado flied out to deep left center to end the inning. Wood needed 56 pitches, 37 for strikes, to complete three innings Saturday night.
After three innings, the game was tied at one.
Welington Castillo led off the fourth with a solo home run to left. Castillo's seventh longball of the season put the Cubs up 2-1. Junior Lake followed with a triple into the left field corner. And Lake scored when Mike Olt hit a sacrifice fly into right … 3-1 Cubs. Barney grounded out to first and Wood strikeout swinging to end the inning. Wade Miley threw 51 pitches, 33 for strikes, over the first four innings.
Travis Wood retired the side in order in the fourth, and it took him only eight pitches to record a 1-2-3 fourth inning (64 pitches, 42 for strikes).
After four innings, the Cubs led 3-1.
The Cubs did nothing in the fifth and Wood took the hill in the home half with a 3-1 lead. Inciarte led off the inning with a ground rule double to right. The ball hit on the warning track and hopped over the wall in right. Wood really started battling himself at that point in the game. Wood issued back-to-back walks to Hill and Goldschmidt that loaded the bases with no outs. Mark Trumbo lined a 2-0 pitch right to Rizzo for the first out. Miguel Montero pulled a 0-1 pitch into the right field corner. Inciarte, Hill and Goldschmidt scored and the D-Backs took a 4-3 lead. Martin Prado lined out to third. Mike Olt made a nice leaping catch and threw toward second to double off Montero. But Olt did not step out of the baseline to make the throw and the ball hit Montero on the helmet. Montero advanced to third when the ball ended up in right field … and he scored when Gerardo Parra blooped a single into left. With Arizona up 5-3, Parra tried to swipe second and was thrown out to end the inning.
Travis Wood needed 91 pitches, 57 for strikes, to complete five innings … and after five innings, the Cubs were down 5-3.
The Cubs went down 1-2-3 in the sixth. Miley retired nine in a row after Lake's triple in the fourth.
The Diamondbacks removed any doubt about the outcome of Saturday's game in the sixth. Nick Ahmed led off the sixth with a double off the base of the wall in left. Wood picked up a strikeout when Miley failed to get a bunt down. Inciarte dropped down a bunt. The ball did not roll far from the plate and Castillo tried to make something happen, and it cost his team. Ahmed was safe by a mile, plus Castillo's throw was high and Inciarte reached first easily. So with runners on the corners and one out, Rick Renteria went to his pen for Carlos Villanueva and brought in Chris Coghlan for Junior Lake in left in the double switch. Hill popped out to Rizzo in foul ground for the second out. Paul Goldschmidt lined a 1-1 pitch into left. Chris Coghlan froze before he broke in on the sinking liner. Coghlan tried to make a diving catch and came up short. Ahmed scored, 6-3 Diamondbacks. With runners on second and third with two down, Mark Trumbo hit a slow roller up the third baseline. Olt made a barehand pick-up, but had no play. Inciarte scored, 7-3 Diamondbacks. Montero grounded out to third to finally end the inning.
After six innings, the Diamondbacks had a commanding 7-3 lead.
The game remained 7-3 until the eighth inning. Zac Rosscup replaced Villanueva and struck out pinch-hitter Nick Evans and Inciarte for the first two outs. Aaron Hill doubled to left and Paul Goldschmidt launched a homer over the wall in left. Goldschmidt's 18th longball of the season made it 9-3 Diamondbacks. Mark Trumbo struck out looking to end the inning.
Oliver Perez pitched the ninth with Arizona up 9-3. Darwin Barney tripled to right with one out, but was stranded when Coghlan fouled out to Montero and Alcantara grounded out to first to end the game.
Jake Arrieta will try to salvage the finale of the series and season series Sunday afternoon (3:10pm CDT) against Josh Collmenter.


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In 1998 Judy Shepard lost her son, Matthew, to a murder that was spawned by anti-gay hatred. Turning tragedy into a crusade for justice, she established the Matthew Shepard Foundation to carry on his legacy.
Judy Shepard will speak at the University of Memphis at 7 p.m. Monday, April 16, in the Michael D. Rose Theatre. Her talk is free and open to the public.
Matthew Shepard was a 21-year-old Wyoming college student when he was savagely beaten to death because of his homosexuality. Since his death, Judy Shepard has testified before the U.S. Senate in support of the Hate Crime Prevention Act and is a frequent speaker on the subject.
News & Events


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I really love this time of year. I know, I know, there's so much advertising, so much commercialism, so much cynicism. But I don't let that stuff get to me. I love looking at lights, I love the music, I love the whole spirit of the holidays. I still watch sappy Christmas movies, and get a little teary. I especially love all the holiday parties at work....mmmm....
So I know that there's so much emphasis right now on giving, and I know you can feel like you're blowing all your savings on not only gifts, but charitable donations. But I'm not after your money, I'm after your blood! Please, consider donating a pint this holiday season. It's truly the gift that keeps on giving, AND it doesn't blow your budget. You can even schedule an appointment, so there'll be no waiting. And don't tell me you're afraid of needles - that's the lamest excuse in the world. You wouldn't say that if it was your loved one in need of a transfusion.
I also forgot to mention that my Charleston Redux post is in the current Carnival of the Infosciences. Check it out, and visit the other entries while you're at it!
Update: Yes, I DID donate a pint of the good stuff, on Nov. 29th. I am O+, so I try to donate 4 times a year, at least. I think I might have actually done it in 2006!


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Review: Born Yesterday
Nina Arianda spreads comic joy on Broadway in the queen of dumb-blond roles.
Mon Apr 25 2011
Photograph: Carol Rosegg
TEACHER'S PET Leonard takes a shine to Arianda
TEACHER'S PET Leonard takes a shine to Arianda.
Time Out Ratings :<strong>Rating: </strong>4/5
Forget yesterday: A star is being born right now at the Cort, and her name is Nina Arianda. No one who saw Arianda's stunning turn Off Broadway in last year's Venus in Fur could emerge uninfatuated: Not since the death of Al Hirschfeld have theater folks gotten such a buzz from finding a Nina. And now the preternaturally poised young actor hits the bull's-eye again as Billie Dawn, the fizzy bottle blond at the center of Born Yesterday.
Is the architecture of Garson Kanin's 1946 comedy a little boxy? Is there something quaint about the moral tug-of-war between Billie's loutish boyfriend, Harry (Belushi, suitably gruff and jowly)—a scrap-metal millionaire with a senator in his pocketbook—and Paul (Leonard, bookishly ardent), the intellectual journalist hired to tutor Billie? Yes and yes—and who cares? When Arianda is onstage, the play is total comic bliss.
Directed with an elegant touch by Doug Hughes, Arianda's Billie Dawn is a take-charge dame, carnally aggressive and self-delighted. Clomping around in Catherine Zuber's exuberant costumes, on John Lee Beatty's beauty of a set, she's a sex toy by way of Shirley Booth; this braying, unapologetic bimbo—"I'm stupid and I like it!"—may be a cousin of Jennifer Tilly's sour Olive in Bullets Over Broadway, but she's utterly adorable instead of appalling. This is the part that made Judy Holliday's career, and Arianda claims it all to herself. She succeeds where many would-be Billies, such as Madeline Kahn and Melanie Griffith, have failed: This is the era of a new Dawn.
Cort Theatre. By Garson Kanin. Dir. Doug Hughes. With Nina Arianda, Robert Sean Leonard, Jim Belushi. 2hrs 30mins. One intermission.


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This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
It has generally been considered that protein phosphatases have more diverse catalytic domain structures and mechanisms than protein kinases; however, gene annotation efforts following the human genome project appeared to have completed the whole array of protein phosphatases. Ser/Thr phosphatases are divided into three subfamilies that have different structures from each other, whereas Tyr phosphatases and dual-specificity phosphatases targeting Tyr, Ser and Thr belong to a single large family based on their common structural features. Several years of research have revealed, however, the existence of unexpected proteins, designated here as "atypical protein phosphatases", that have structural and enzymatic features different from those of the known protein phosphatases and are involved in important biological processes. In this review, we focus on the identification and functional characterization of atypical protein phosphatases, represented by eyes absent (EYA), suppressor of T-cell receptor signaling (Sts) and phosphoglycerate mutase family member 5 (PGAM5) and discuss their biological significance in cellular signaling.
Protein kinases have highly conserved catalytic domain structures, irrespective of their substrate specificity, and all protein kinases were annotated relatively soon after the human genome project was completed [
Eyes absent (EYA) was originally identified as a novel nuclear protein in
In 2003, three independent research groups simultaneously reported that EYA is not only a transcription factor, but also a protein Tyr phosphatase [
Nuclear phosphorylation of the histone variant, H2AX, is a crucial component in DNA damage repair. It has recently been shown that DNA damage induces the interaction of EYA with H2AX through phosphorylation of EYA by the DNA-damage-response protein kinases, ataxia telangiectasia mutated (ATM) and ataxia-telangiectasia and Rad-3-related (ATR) [
Consistent with the finding that the overexpression of some of the EYA isoforms correlates with tumor growth and increased metastasis in various cancers [
More recently, it has unexpectedly been found that EYA functions also as a protein Thr phosphatase [
Importantly, the Thr phosphatase activity, but not the Tyr phosphatase activity, of EYA4 plays a critical role in innate immunity [
A role for EYA in innate immunity has been shown to be conserved among species [
Suppressor of T-cell receptor signaling-1 (Sts-1), also known as p70 or T-cell ubiquitin ligand 2 (TULA2), was originally identified as a protein that binds Janus kinase 2 (Jak2), a protein Tyr kinase involved in a specific subset of cytokine receptor signaling pathways [
Sts-1 and Sts-2 are members of the phosphoglycerate mutase (PGAM) family (
Signaling through the multisubunit T-cell antigen receptor (TCR) precisely controls the development and function of T-lymphocytes, which play a critical role in the recognition and elimination of foreign pathogens [
Later analysis revealed that Sts-1 has an intrinsic protein Tyr phosphatase activity associated with the C-terminal PGAM domain [
In contrast to Sts-1, the intrinsic phosphatase activity of Sts-2 is known to be quite low, although its PGAM domain is highly homologous to that of Sts-1 and retains the conserved catalytic core of two His and two Arg [
As mentioned above, Sts-1 and Sts-2 were identified as interacting proteins of c-Cbl. They bind c-Cbl through their SH3 domains and are recruited to epidermal growth factor (EGF) receptor (EGFR) with c-Cbl upon EGF stimulation. They then suppress the internalization and subsequent degradation of EGFR, enhancing the downstream signaling of EGFR [
In addition to stabilizing EGFR, Sts-2 inhibits the uptake of transferrin and low-density lipoprotein (LDL), suggesting that Sts-2 negatively regulates clathrin-dependent endocytosis in general [
Syk, a protein Tyr kinase that plays a crucial role in lymphoid signaling, is another dephosphorylation target of Sts-1 [
PGAM5 is another member of the PGAM family and possesses the PGAM domain and an N-terminal transmembrane (TM) domain (
Independently of the above-mentioned studies, our group identified PGAM5 as an interacting protein of a stress-activated protein kinase apoptosis signal-regulating kinase 1 (ASK1) in a pull-down-based proteomic analysis [
During the investigation of the mechanism of PGAM5-induced ASK1 activation, PGAM5 was found to dephosphorylate the basally phosphorylated C-terminal region of ASK1 directly [
Similar to Sts-1/2, the catalytic structure and probable catalytic mechanism of PGAM5 are different from those of the classical Ser/Thr phosphatases described above. Intriguingly, the primary structures of the catalytic domains of Sts-1/2 and PGAM5 are highly homologous to each other, indicating that PGAM5 and Sts-1/2 constitute a novel and unique family of protein phosphatases with distinctly different substrate specificities, in spite of their similar structures. Therefore, Tyr-specific and Ser/Thr-specific protein phosphatases do not necessarily possess different structures from each other.
The biochemical and structural features of the PGAM family members are also shared with those of the His acid phosphatase family of enzymes as described above [
It has recently been demonstrated that PGAM5 is predominantly localized to the inner mitochondrial membrane (IMM) with the
This possibility is supported by the recently found genetic interaction between PGAM5 and PINK1 in
Recent findings suggest that PGAM5 has both anti- and pro-apoptotic functions. Flies deficient in dPGAM5 exhibited increased vulnerability to heat shock stress [
In contrast, it has been reported that PGAM5 bridges Keap1 and Bcl-xL and facilitates the Keap1-E3 ligase complex-mediated degradation of Bcl-xL and subsequent apoptosis, suggesting the pro-apoptotic role of PGAM5 [
On the other hand, PGAM5 has been shown to be involved in the induction of programmed necrosis, called necroptosis. Necroptosis is induced by the ligation of death domain-containing receptors, including TNF receptor 1 (TNFR1) and TNFR2, under specific conditions in which caspases are inhibited [
The unique molecular and functional features of atypical protein phosphatases reviewed here reveal that protein phosphatases are more diverse than previously thought and strongly suggest that there are unique protein phosphatases whose structural features are beyond our current knowledge. Some findings implicating the involvement of atypical protein phosphatases in human diseases are important indicators that therapeutic targets for diseases that arise from dysregulation of protein dephosphorylation are not necessarily restricted to known protein phosphatases. Therefore, a broad range of research on the molecular functions of each atypical protein phosphatase, including identification of its substrates and an extensive exploration for new protein phosphatases, will expand our knowledge about protein phosphorylation and dephosphorylation and their physiological and pathophysiological significance.
We thank H. Ichijo and his laboratory members for valuable discussions. This work was supported by the Japanese Science and Technology Agency (JST) Precursory Research for Embryonic Science and Technology (PRESTO) program and a grant from the Mitsubishi Foundation.
The authors declare no conflict of interest.
"Classical" and "atypical" protein phosphatases in humans. Protein Tyr phosphatases and dual-specificity phosphatases constitute a single large family of Cys-based phosphatases, whereas protein Ser/Thr phosphatases are divided into three subfamilies, the phosphoprotein phosphatase (PPP), protein phosphatase Mg2+- or Mn2+-dependent (PPM) (PP2C) and FCP families. Eyes absent (EYA), suppressor of T-cell receptor signaling (Sts) and phosphoglycerate mutase family member 5 (PGAM5) are recently characterized "atypical" protein phosphatases that do not belong to the "classical" protein phosphatase families. Numbers in parentheses indicate the number of genes encoding each family member. Many members of the PPP family consist of multiple subunits; therefore, only the genes encoding the catalytic subunits are counted. PTP, protein Tyr phosphatase; LMPTP, low molecular weight PTP; VH1-like DSP, Vaccinia virus gene H1-like dual-specificity phosphatase; PPP, phosphoprotein phosphatase; PPM, metal-dependent protein phosphatase; FCP, TFIIF-associating component of RNA polymerase II carboxy-terminal domain phosphatase.
The primary structure of EYA. The structural features of the EYAs and the amino acid sequences of the phosphatase domains of mouse EYA1–EYA4 and
Regulation of the phosphorylation of H2AX and cellular responses to DNA damage. Upon DNA damage, EYA dephosphorylates Tyr142 of H2AX, facilitating phosphorylation of Ser139 of H2AX. If the damage can be repaired, a series of DNA repair factors, including MDC1, are recruited to H2AX. If the damage cannot be repaired, however, an apoptosis-inducing complex, including JNK1, is formed on H2AX, most likely through persistent phosphorylation or re-phosphorylation of Tyr142, indicated by dashed arrows.
The phosphoglycerate mutase (PGAM) family. Human PGAM family members and their domain structures are shown. A phylogenetic tree was created by the alignment of PGAM domains using the ClustalW program. BPGM, 2,3-bisphosphoglycerate mutase; TIGAR, TP53-induced glycolysis and apoptosis regulator; PFKFB, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase.
Mitochondrial membrane potential-dependent cleavage of PGAM5 by presenilin-associated rhomboid-like (PARL). PGAM5 is predominantly localized to the inner mitochondrial membrane (IMM) and is cleaved in its


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Last week, Cooking Channel staff was fortunate enough to attend the second-annual LUCKYRICE Festival, an exciting, week-long tribute to the incredible diversity of Asian culinary culture.
The NYC-based festival featured truly unique events hosted by talented chefs who specialize in Asian cuisine, including Iron Chef Morimoto, chef Ming Tsai, and Cooking Channel's own Ching-He Huang (see the full list or participants here).
Here are some highlights from the event:
Continue Reading Lucky Rice Festival: Celebrating Asian Cuisine


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text: Hot Topics All About Barbour Barbour has been a perennial favorite for classic, hard-wearing outerwear that works in both business and casual environments (or even in that dreaded, middle ground, "business casual"). This thread is all about Barbour – from what jacket has been destroyed by James Bond in Skyfall (please do not ask about that jacket!) to what surprising Japanese designer Barbour is teaming up with for their next collection. Take a read. Cloth Do you buy lots of cloth for future bespoke purchases? Do you know what the acronym "CMT" means? Do you have all the latest W. Bill tweed swatch books on your desk right next to pictures of your kids? If so, this thread is for! (You might be a cloth addict, if...) Deal of the Day Sid Mashburn Double Monks, 8.5 B&S Finds Rick Owens T-Shirt, 50 Brioni Cashmere Knit Tie


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Also wondering if you reccomend an overnight hospital stay.
Do You Reccomend Lovenox Injections for DVT/PE Prevention After TT and if So, for How Long?
Doctor Answers 8
Do You Reccomend Lovenox Injections for DVT/PE Prevention After TT and if So, for How Long?
My patients stay over for 1-2 nights after and if I am combining TT and Lipo, or TT in a larger patient, then I do give DVT prophylaxis.... Heparin 5000u sub Q before anesthesia and then Lovenox for several days after....I have had 7 or so patients in 20 years develop a DVT, all did well and all were associated with TT or TT/Lipo
Lovenox for tummy tucks
The previous posts all provide very good information. I personally prescribe Lovenox for all of my patients who are having a tummy tuck, as this procedure is the highest risk in the Plastic Surgery field for PE/DVT. I have my patients start their first dose 3 hours prior to surgery, and I do require an overnight stay after surgery. I have not seen an increase in post operative bleeding, and I believe that this greatly decreases the risk of a pulmonary embolism or deep vein thrombosis, so I am able to sleep better! If a patient is adverse to using the Lovenox, it is their choice, but I always give them a Rx for it.
Lovenox After Tummy Tuck
Dear Galena,
The complication of a Deep Venous Thrombosis or a Pulmonary Embolism is one of the most dreaded in Tummy Tuck surgery. It can strike out of seemingly nowhere and can be fatal. Once it has occurred, it will require at minimum months of treatment and medication which is not without its own set of risks and complications. This is why ASPS has been working to define a set of guidelines for its member plastic surgeons to use to minimize these risks by using anticoagulation during surgery to decrease the risks of developing blood clots.
As of September 2011, the new guidelines by the ASPS VTE Task Force strongly recommended anticoagulation in patients undergoing major surgery lasting over a certain period of time and with certain risk factors. These risk factors are based on a scale that accounts for the patient's age, their past medical history, their medications, their family history, and the type of procedure being performed. The surgeon adds the point total after performing the evaluation and then determines whether to use anticoagulation or not based on the resulting numbers. Many patients who are going to have a tummy tuck will have enough risk factors to make a strong case for anticoagulation treatment. There are lots of options for what type of anticoagulation to use including Lovenox, Arixtra, and others.
Please discuss this very important question with your plastic surgeon who can explain your risks and their recommendations based on those risks. While there are some risks associated with anticoagulation, none of them are commonly fatal like a PE.
Hope this helps.
You might also like...
Tummy Tuck -DVT/PE, Lovenox and Heparin
This is an excellent and timely question. Guidelines are slowly being established through discussion and sharing of information but, at this point, you will find many different answers to these questions. In my practice, I typically perform these procedures in my office surgical facility, under DIVA (deep intravenous anesthesia), we use compression devices for the lower legs, encourage and insist on early ambulation (including within a few hours of the surgery) AND I typically give a single dose of heparin (5000 units) just before the procedure. Of course, this depends on individual characteristics of the patient, and applies to relatively young and healthy patients. With increasing comorbidities (heavier, medical problems, associated procedures, longer cases) I am more likely to do the procedure in a hospital. In that case we typically use general anesthesia and early ambulation is more difficult to achieve, so I'm more likely to use heparin initially and then several doses of Lovenox until the patient is discharged and clearly ambulatory.
So the answer is - it depends! Which, of course, is often the case...
I hope that this helps and good luck,
Dr. E
Learn more: http://www.bodysculpture.com
Lovenox after tummy tucks
great question. This has been discussed at great length by both plastic surgeons and all surgeons for that matter. I personally go by personal history and risk factors. If you have low risk factors and no personal history, I do not anti-coagulate, but use compression stockings and early mobilization. I perform the procedure as an outpatient, use pain pumps to permit earlier mobilization. Time under anesthesia also plays a role, as some surgeons take up to twice the amount of time to perform procedures.
I would recommend you discuss this with your surgeon. Go over your risk factors, your history, and the specifics about your case, ie time in the operating room, other procedures being performed on the same day,etc.
I also start the anti-coagulation, before the case when there is increased risk for DVT.
Learn more: http://www.drrickrosen.com/tummy-tuck-connecticut/
DVT/PE after tummy tuck
This a very important question as the risk of DVT/PE is perhaps the most worrisome complication of an abdominoplasty procedure. The risks of DVT/PE are increased by a handful of factors including:
1) Dehydration: thats why you should received plenty of IV fluids during surgery and make sure you drink lots of water when you go home.
2) Lack of movement: Sequential compression devices during surgery and a pillow under the knees during surgery will help. Movement at home including walking around the night of surgery will also help.
3) Medications: Certain medications such as birth control pills can increase the chance of DVT/PE. Medications such as Lovenox can help reduce the risk but increase the risk of bleeding. Surgeons differ on how these medications are used. Some utilize them only after surgery, others before.
4) Genetics: Our bodys's clotting ability ranges from too little to too much and everything in between. Certain blood abnormalities increase the chance of blood clotting and DVT/PE. Your history or family history may hint at this which should be followed up by a workup if suspected.
I hope this helps.
All the best,
Dr Remus Repta
Learn more: http://www.aaaplasticsurgery.com
Lovenox after tummy tuck
The risk of DVT after tummy tuck is a real risk, and the key is prevention. For all, we use sequential conpression and stockings. Lovenox can reduce the risk, and there are methods to score patients for DVT risk, and if the number is right then Lovenox is prescribed. Lovenox is started by injection 12 hours after the procedure, and continued daily for five days, and is easy to self administer with instruction. In our practice, overnight stay is not common.
Best of luck,
Peter Johnson, MD
Learn more: http://www.peterejohnsonmd.com/tummy-tuck
Lovenox and Tummy Tucks
This is a very good question. The recommendations are really up and coming with regard to how often lovenox or anticoagulation in general should be used in major plastic surgery operations. Right now most plastic surgeons go by the recommendations by the American Society of Chest/Thoracic surgeons. Multiple category groups exist but in general a patient should be considered for anticoagulation if they meet some of these criteria: surgery expected to last longer than 2 hours, obese, on birth control or taking estrogen supplements, history of cancer of any kind, history of prior DVT, recent pregnancy or abortion to name a few. Depending on which categories you fall into it may be very reasonable and appropriate for your plastic surgeon to suggest lovenox tx. I typically use injections for about 5 days or until you are really up and ambulating without problems if I feel they are indicated. At my Austin, Texas area plastic surgery practice overnight stay in the hospital is something we always have available to our patients and I often require it for anyone having over 6 + hours of surgery. Hope that helps, Dr. Kerr
These answers are for educational purposes and should not be relied upon as a substitute for medical advice you may receive from your physician. If you have a medical emergency, please call 911. These answers do not constitute or initiate a patient/doctor relationship.


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MLP Investors Risk Yielding to Excess
In our quantitatively eased world, the new "dot-com" is "yield". Investors in one of the hottest payout sectors, master limited partnerships or MLPs, should be alert for signs of a bubble.
One possibility has arrived in the form of an announcement that Alon USA Energy intends to put its Big Spring, Tex., refinery into a separately listed MLP.
This is unusual. MLPs are traditionally backed by assets such as...


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If you are looking for some of the best alternatives to Steroids it is always a good idea to read the Internet bodybuilding forums to see who is logging the supplement and what are their end results. I've scanned a lot of USPLabs Prime reviews as well as taken USPLabs Prime myself and have found it to be one of the alternatives to steroids on the market today.
You can find USP Prime reviews on several supplement and bodybuilding forums or the review pages on internet supplement retailers. There are many claims as to what the best steroid alternatives are but you will find a lot of consistency when reading USP Prime reviews out there on the Internet.
USPLabs Prime doesn't work through androgenic or hormonal activity like designer steroids do but is believed to act through anti-glucocorticoid effects, providing a possible mechanism for the increase in muscle mass seen with USP Labs Prime.
Pro-hormones, pro-steroids, and designer steroids work by increasing anabolic hormones in the body which will also cause your natural testosterone production to drop. This requires doing PCT (post cycle therapy) and there is always a risk of losing muscle gains during this period of time. USPLabs Prime method of action is not hormonal so there is no loss of muscle mass after completing the the cycle of the product. View testimonies below.
Most of the USP Prime reviews will state the gains are not noticeable as designer steroids or prohormones but when you factor in a complete lack of side effects and keeping 100% of your muscle gains it makes it one of the best alternatives to steroids that you can purchase. I've read some reviews that say the price isn't worth it but I for one don't see it that way.
Since USPLabs Prime is not liver toxic and does not cause hormonal shutdown there is no need for extra supplements like milk thistle for the liver or PCT supplements to kick your natural hormones back to their normal levels. The best steroid alternatives should not only be cost effective but they should allow you to maintain your muscle gains as well as your good health.
When I used USPLabs Prime I found my recovery in the gym was faster than ever but I did have to take the higher recommended dose because of my heavy weight to feel these effects. It was well worth the muscle and strength gains and the lack of lethargy and other side effects you get with designer steroids or pro-hormones.
Overall many of the USP Prime reviews praise the product but you will also read about the guy that made no gains at all. It doesn't really matter what supplement you take you still need to workout hard and follow proper nutritional guidelines to make any gains at all. I often wonder about the guys that complain of not making any muscle gains at all because regardless of if they used a supplement or not if they were at least eating right and working out correctly they would make some kind of gains.
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MacTutor History of Mathematics Archive
Extensive biographies with references and links to related topics. Special indexes offer timelines, birthplace maps, quotations, a directory of female mathematicians, and more. May be searched by time period or by name. Maintained by the School of Mathematics and Statistics at the University of St. Andrews, Scotland.


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Florence Lifestyle
Florence is one of the great World capitals of culture. You can find museums, exhibitions, art galleries and historical buildings in every corner of the city.
But Florence is not only art. Gourmet cuisine, a buzzing nightlife and shopping make it one of the top destinations, seducing all kinds of tourists throughout the whole year.
Hotel Orto de' Medici is at the center of this and much more.
Go discover this kaleidoscopic city guided by those who have lived in Florence for generations.


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Log in
Rick Bragg's visit last week was the highlight of our National Library Week celebration as we concluded this year's Reading Together program.
You helped us celebrate with the bright yellow "Library Champion" signs in yards throughout our service area and we have added "Library Champion" photos to our website. Send us yours! Cute kids and dogs are the most popular ones to pose by their yard signs so far! Thanks to the Friends of KPL for funding these signs.
The Friends of KPL also celebrated "National Library Workers Day" on Wednesday with a cake for the KPL staff and a discount in their bookstore. We have good Friends!
It was a good week.
Posted by Ann Rohrbaugh at 04/23/2009 08:10:52 AM |
Books for: Kids, Teens & Tweens


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Alesco chief executive
The board yesterday said it had accepted Mr Ryan's resignation effective immediately and gave no reason for the departure.
Mr Ryan was in the job four years. When contacted by phone by The Australian Financial Review he declined to comment about his exit or plans. He will receive a $1.7 million separation package plus any statutory entitlements.
Mr Ryan's departure follows a tough 18 months when Alesco revealed several earnings downgrades and posted a loss of $12.8 million in the 12 months ended May 31, 2009.
Alesco has a large exposure to the building sector with four divisions: construction and mining, functional and decorative products, garage doors and openers, and water products, which is under review.
The Sydney-based company, which generates about $1 billion in revenue a year, distributes cabinets, panelling, truck tires and other industrial products.
Late January, Mr Ryan confirmed 2010 full-year earnings per share forecast of 34¢ to 36¢. Five weeks later he slashed the forecast to between 24¢ and 27¢. Earnings per share in 2008 were 83.8¢.
"The board has taken the view enough is enough," one analyst said.
Mr Luby, who took over as chairman in September, denied there was any tension between the two or that shareholders pushed for Mr Ryan's departure.
"Justin has tendered his resignation and we are pleased we have the opportunity to put Peter Boyd into the role. He has done a great job in the garage doors and openers for the last three years."
Mr Luby said Mr Boyd brings a lot of operational experience to the table given his background running Boral's timber division.
But market rumours persisted yesterday that there had been a clash.
"I wouldn't be surprised if there was some quiet lobbying in the background," one major shareholder said.
"We weren't expecting this, but the last earnings downgrade didn't look too good.
"There are two sides to the coin, share price and earnings over the past 18 months have been disappointing . . . but Justin did a reasonably good job with a cyclical company."
Mr Luby has a lot of operation experience, spending 29 years at Brambles, while Mr Ryan has expertise in corporate mergers and acquisitions.
Alesco's top three shareholders include BT Investment Management with 6.68 per cent, Northcape Capital with 5.07 per cent, and Dimensional Fund Management with 4.95 per cent.
The Australian Financial Review