text:
Pulmonary Allergy Drugs Advisory Committee
September 6, 2002
Holiday Inn Gaithersburg
New Drug Application (NDA) 21-395, Spiriva (Tiotropium bromide) by Boehringer-Ingelheim for chronic obstructive pulmonary disease (COPD).
Mark S. Dykewicz, M.D.
Andrea J. Apter, M.D.
Polly E. Parsons, M.D.
T. Prescott Atkinson, M.D., Ph.D.
Erik Swenson, M.D.
Peter E. Morris, M.D., FACP, FCCP
Jesse Joad, M.D.
Vernon Chinchilli, Ph.D.
Karen Schell, RRT
William Kennedy, Ph.D.
Kimberly Littleton Topper
Consultants (voting)
James K. Stoller, M.S., M.D.
Donald Patrick, Ph.D.
Guest Speaker (non-voting)
Michael Schatz, M.D.
Robert Meyer, M.D.
Badrul Chowdhury, M.D.
Eugene Sullivan, M.D.
Lisa Kammerman, Ph.D.
I certify that I attended the September 6, 2002 meeting of the Pulmonary-Allergy Drugs Advisory Committee and that these minutes accurately reflect what transpired.
Kimberly L. Topper, MS Date Mark S. Dykewicz, M.D. Date
Executive Secretary Chairman
A verbatim transcript of this meeting is available for more detailed information.
Pulmonary Allergy Drugs Advisory Committee
September 6, 2002
New Drug Application (NDA) 21-395, Spiriva (Tiotropium bromide) by Boehringer-Ingelheim for chronic obstructive pulmonary disease (COPD).
The meeting was called to order by Dr. Mark Dykewicz at 7:30 AM. Introductions of the committee members, consultants and guests were made and the Conflict of Interest statement was read into the record. Dr. Robert Meyer welcomed the committee and thanked them for attending and Dr. Badrul Chowdhury set the stage for the topic of the day's discussions.
Boehringer Ingelheim had the following presentations:
Introduction and Overview Dr. Burkhard Blank
Dr. Blank provided the BI introduction to the topic by explaining what COPD is and giving statistics about the disease progression and mortality rates. He stated their major topics for the day were 24-hour bronchodilation, the relief of dyspnea and the safety profile. The proposed indication was presented as:
SPIRIVA® (tiotropium) is indicated for the long-term, once-daily, maintenance treatment of bronchospasm and dyspnea associated with Chronic Obstructive Pulmonary Disease (COPD) including bronchitis and emphysema.
He then introduced each speaker and the topics they would present.
Bronchodilator Efficacy in COPD Dr. Bernd Disse
Dr. Disse concluded Tiotropium once-daily provides sustained improvement of spirometric measures for 24 hours, patient improvements were maintained over one year, with no evidence of tachyphylaxis, and secondary endpoints and exploratory analyses show improvements of related lung function, exacerbations, and the patient health status.
Quantification of Dyspnea Dr. Paul Jones
Dr. Jones discussed the quantification of dyspnea and covered the measurement of breathlessness, the validation of BDI and TDI and the identification of clinically significant thresholds.
Dyspnea and Related Measures Dr. Theodore Witek
Dr. Witek discussed the use of dyspnea assessments in clinical trials stating the long-term assessments are particularly important in chronic disease maintenance treatment. He also stated that the instrument needs to be practical in a multi-center and multi-national setting, dyspnea assessment needs to be in context of a clinic visit and supportive assessments should be included to assist in determining validity and consistency. He closed by stating that the effect of tiotropium on dyspnea was supported by the use of a validated instrument, prespecification of a primary endpoint, statistical significance observed in two independent studies, meaningful change supported by mean responses and dyspnea response reflected in related measures.
Clinical Safety Evaluation Dr. Steven Kesten
Dr. Kesten discussed the clinical safety evaluating stating that tiotropium has had extensive clinical safety evaluations with a large patient population and long-term exposures. He indicated that the safety profile is similar to that of ipratropium. The safety data included long-term studies of 1,308 tiotropium treated patients, adverse events were consistent with anticholinergic pharmacology, there were no associations of treatment with life-threatening events and the tiotropium safety profile is consistent with established inhaled anticholinergic therapy.
Clinical Perspective Dr. James Donohue
Dr. Donohue discussed the typical patient with COPD and the disease progression and the challenges in demonstrating dyspnea relief in clinical studies. He stated that he believes that tiotropium would be a valuable addition to the medical armamentarium.
Conclusions Dr. Burkhard Blank
Dr. Blank them concluded the BI presentations by stating the major topics for discussion were the safety profile, the 24-hour bronchodilation and the relief of dyspnea.
The Food and Drug Administration had the following presentations:
Transition Dyspnea Index (TDI) Dr. Lisa Kammerman
Dr. Kammerman discussed the Baseline Dyspnea Index (BDI)/Transition Dyspnea Index (TDI), the history of the use of the TDI as a co-primary endpoint in the tiotropium program, and FDA concerns regarding the BDI/TDI, including clinical trial design issues, development and validation issues, implementation issues, and the importance of establishing a threshold for a clinically meaningful difference. She concluded that the patient level issues were the unknown level of patient involvement in the development of the instrument and in the determination of a minimal clinically important difference. The interviewer level issues were the blinding of patient status, training of interviewers, open-ended questions, non-standardized questions, recall to baseline and the review of the SGRQ before completion of the TDI. She stated that the clinically meaningful difference appeared to be determined with no prespecified plan and no patient involvement to determine the clinically meaningful difference. There were also concerns about who administered the TDI and the impact of multinational populations as it impacts development, validation and interpretation of results.
PK/PD, Safety & Efficacy Dr. Eugene Sullivan Dr. Sullivan covered the proposed indications, the PK/PD characteristics, a brief overview of the P3 clinical program, and the safety and efficacy findings. He summarized his findings by stating some of the PK/PD features of tiotropium are unique among inhaled bronchodilators. Concerns about safety are, the dry mouth, which shows interactions with age and gender and is more frequent in tiotropium than with ipratropium, a higher frequency of AE's with tiotropium than with placebo and the possible effect on the heart rate/rhythm may merit further evaluation. Dr. Sullivan's discussions on the efficacy showed that SpirivaÒ appears to provide clinically meaningful bronchodilation, the duration of action supports once-daily dosing, the maximum bronchodilator effect is reached after multiple daily doses and it has an demonstrable statistical effect on the TDI however, the clinical significance of this effect is not known.
Following the presentations the committee questioned the presenters for clarification on specific points of the presentations.
The Open Public Hearing had one presenter, Vlady Rozenbaum, Ph.D. He encouraged getting Spiriva® to the market as soon as safely possible. There were also 55 e-mails and letters that were given to the committee from others that would like to see Spiriva® on the market in the US.
The committee started the discussion of the issues and both FDA and BI participated in the discussions. The Committee members then moved on to the questions.
Schell - yes Chinchilli – yes Apter – yes Swenson – no Dykewicz – yes Stoller – yes Joad – no Morris – no
Atkinson – yes Parsons – yes Patrick - yes
Yes ___11_____ No ___0_____
Schell – yes Chinchilli – yes Apter – yes Swenson – yes
Dykewicz – yes Stoller – yes Joad – yes Morris – yes
Atkinson – yes Parsons – yes Patrick – yes
Yes ___0_____ No ____11____
Schell – no Chinchilli - no Apter- no Swenson- no
Dykewicz- no Stoller – no Joad – no Morris - no
Atkinson – no Parsons – no Patrick - no
The Chair and FDA staff thanked everyone for their participation and the meeting was adjourned at 3:05 PM.


text:
2.050 2016-09-17
Bug fix:
* model generator: fix call to load (gh #2).
(Thanks Slaven Rezić)
* fix doc typo in LCDd.conf
2.049 2016-07-15
* merge gen_LCDd_model in lcdconf2model (gh #1)
* update © years of generated model
* remove obsolete text in description
2.048 2016-07-13
Usability improvements:
* added CONTRIBUTING.md
* gen_LCDd_model: use exec instead of require to get correct
error message when model generation fails
Bug fix:
* adapted model generation to new warp parameter (Debian #829442)
2.047 2016-03-08
Bug fix: let Config::Model initialise log4perl during model
generation to avoid failure when ~/.log4configmodel does not exist
2.046 2016-01-25
Fix dist.ini to update Config::Model dependency correctly
(i.e. >= v 2.076)
2.045 2016-01-24
This release fix a limitation of "cme edit lcdproc". User can now
enable more than one driver (i.e. set lirc and imonlcd drivers)
(this requires Config::Model 2.076)
2.044 2016-01-02
* Fix pod documentation re-generation which broke smoke tests on solaris.
2.043 2015-12-31
Bug fix release to cope with a change on Config::Model::Iself.
The scripts used to generate lcdproc model will now complain in case of
* gen_LCDd_model: use new cm_lib_dir param (Debian #808853)
* require Config::Model::Itself >= 2.001
* Build.PL: exit 1 when model generation fails
* gen_LCDd_model: exit 1 when model generation fails
The model generator changes are:
* specs specified between {...} can override specs specified between [...].
New syntax : {% and %}
* specify value type in all cases
* handle specs between [ and ] that span several lines
In case of issue, please now use github bug tracker:
2.042 2014-05-25
The lcdproc model of this release is made for ldcproc 0.5.7. Only a very
small modification of LCDd.conf comments was required to be able to
generate a complete lcdproc model from LCDd.conf.
* Build.PL: run script/gen_LCDd_model.pl at build time
* AnyEvent is no longer needed in tests
* LCDd.conf: modified comment to avoid Device being interpreted as list ...
* lcdconf2model: improved parsing of legal spec from LCDd.conf comments
2.041 2014-01-24
* require perl 5.10 (like Config::Model)
* LCDd model generator:
* off,on values are now boolean. cme will be more tolerant on
input values (e.g. 'no' will be converted to 'off')
* removed [.*] from generated doc of LCDd configuration elements
2.040 2013-09-22
* LCDd.conf v0.5.6 patches:
* Specify yes/no as legal values for Foreground (so it becomes a boolean)
* specify ReportLevel default value is square brackets
* LCDd model generator:
* yes,no values are now boolean (requires Config::Model 2.043)
* ignore default value from file when square brackets are specified
* don't initialise Hello and GoodBye arrays
* default value mentioned in square brackets are used as upstream_default
* tweak model to ensure that DriverPath will end with a slash
* test upgrade from original lcdproc config file with 0.5.5 and 0.5.6
2.039 2013-06-19
* model_test.t: avoid warnings in smoke tests
* updated doc
* model generator: fixed comments
* model generator: updated (c) years
0.001 2013-06-15
* imported LCDd.conf from lcdproc 0.5.6
* LCDd.conf: removed extra comment that trips model generation
See Config::Model Changes for older logs

subset: commoncrawl


text:
What are the important events that happened on May 14, 1951? Here are historical events, facts, and some myths about this day.
May 14, 1951: Facts & Myths About This Day
May 14, 1951 is the 134th day of the year 1951 in the Gregorian calendar. There are 231 days remaining until the end of this year. The day of the week is Monday.
Under the Julian calendar, this day is May 1, 1951 – a Monday. Both day of the week are the same but did you notice the difference with the Gregorian calendar?
Strange as it may, if we name this day after a polygon then it will be called 'hectatriacontatetragon' day.
Hey! How's your career today? Get the Career Analysis Report and improve your earning power. Start to seize career opportunities today! (Sponsored link)
If a person born on this day saved a Half dollar every day starting at age 4, then by now that person has accumulated $11,360.50. (Assuming this person is still alive today.)
Taurus is the zodiac sign of a person born on this day. Emerald is the modern birthstone for this month. Sapphire is the mystical birthstone from Tibetan origin that dates back over a thousand years.
Rabbit is the mythical animal and Metal is the element for this person if we consider the very old art of Chinese astrology.
Curious to find out some fun birthday facts about May 14, 1951? Listen to the number-one song on the day you were born. Find out what your birthday means! (Sponsored link)
May 14, 1951 Historical Events
- 1951 –Trains run on the Talyllyn Railway in Wales for the first time since preservation, making it the first railway in the world to be operated by volunteers.
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text:
Extra demand, same supply nudges up hotel rates
April 28, 2013
February Occupancy/Average Daily Rates
Greeley had the highest occupancy rate in the state in February, with only Vail coming close at 80.6 percent occupancy.
Greeley 81.8 percent /$92.16
Loveland 63.3 percent/ $103.57
Fort Collins 52.5 percent/$90.16
Source: Rocky Mountain Lodging Report, February 2013, by Colorado Hotel and Lodging Association
2012 Colorado average room rates
Jan. $130
Feb. $137
March $138
April $113
May $113
June $123
July $124
Aug. $125
Sept. $119
Oct. $120
Nov. $106
Dec. $140
Source: Rocky Mountain Lodging Report, February 2013, by Colorado Hotel and Lodging Association
While demand for hotel rooms has skyrocketed in the last year in Greeley, so too have the daily rates.
Many Greeley area hotels are charging $100 and more for daily room rentals, while their counterparts in Loveland and Fort Collins are charging much less.
Why? Because they can. It's ECON 101.
"We have Loveland and Fort Collins hotels visiting often asking us to send people their way," said Brian Van Buskirk , general manager of the Fairfield Inn & Suites, 2401 29th St. in Greeley. "It's amazing what 20 miles can do. Our market is so hot, and Loveland and Fort Collins are struggling. They draw people in with the lower rates. It's basically supply and demand."
Greeley hotel occupancy has remained the highest in the state for months, coming out of February at 82 percent . It's chiefly a result of the oil and gas activity, as well as the construction workers building Leprino Foods, managers say.
It's growing every year, which nudges up prices.
According to the Rocky Mountain Lodging Report, average daily rates in Greeley in February were $92.16, a couple of dollars above Fort Collins, but still well below Loveland's rate of $103.57.
But that picture is slowly changing.
At the Hampton Inn properties in all three cities, prices varied widely last week: In Greeley, a daily room started at $149; in Loveland, rates started at $129; Fort Collins costs the least at $119 a night.
"Our prices have gone up significantly," said Robert Julich , division manager for Greeley's Hampton Inn, 2350 29th St. "They'll probably continue to go up."
Last summer, he said, Greeley rates started at $119 a night. This summer it may go up to $169 a night, he said.
"Some complain, but there's so many denials — the people who were turned away — someone will rent the room," Julich said.
Frank Brewster , co-owner of Days Inn, 5630 10th St. in Greeley, raised his rates $5 per room across the board this year in anticipation of a busy summer. People will be able to rent his rooms for $89 a night.
"I try to be the Walmart of hotels," he said. "With inflation the way it is, I think the days of $100 a night per hotel room is not far off. Everyone expects more, but those things cost money. Free WiFi, free breakfast. Costs will continue to go up."
The ways hotels are figuring their rates are evolving, as well. In some hotels, prices increase in the last rooms booked.
Some hotel brands have analysts that check the market, room demand and average prices daily, and change prices often.
"It's just like the airlines," Van Buskirk said. "Some days, with the demand, you could sell the rooms three times over the market. We don't gouge, but we just keep it right at average market levels based on the quality of the product."
The last two years has really provided hotels a boost in Greeley; but their rates have provided the city of Greeley a boost in tax revenue. The city charges a 3 percent tax on the price of every lodging room in Greeley, revenues dedicated to promoting tourism and marketing for the town.
In 2012, lodging tax for the city grew 15 percent, and the city was able to allocate $221,500 for the Visit Greeley program through the Greeley Chamber of Commerce, plus an extra $80,000 for the Greeley marketing campaign. Last year, the Visit Greeley program received $180,000, said Victoria Runkle, city finance director.
More may be coming. Two new hotels are under construction.
Spirit Hospitality in Fort Collins is building its second Greeley hotel, a Candlewood Suites extended stay hotel off of 35th Avenue. Homewood Suites is an 80-room hotel planned in the Centerplace shopping area, but construction has not yet begun.
Candlewood has planned an August opening, but local hotel officials say the market could withstand both hotels opening much sooner than later.
"We definitely know there is a need for rooms," said Renee von Weiland, vice president of operations at Spirit Hospitality, which also has three other brands in Loveland. "We've been taking a lot of Greeley overflow for the last year."
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text:
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HFA Consultations
Consultations are available with Grant Bentley via email, skype and phone.
For more information about the clinical process click here.
- First consultation is $180AUD (Australian Dollars)
- Currency converter here
- A deposit of $50AUD is made to Grant Bentley, using an online credit card payment system
- A proforma will be sent to you by email asking details regarding your symptoms
- You forward this completed proforma back by email
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Remedy to be secured within own country where possible - if not remedy will be sent from Australia (postage charges will apply outside of Australia)
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Book online here for your consultation (payment using secure server)


text:
Nearly 15 years ago, Audi joined an emerging crossover trend by raising the suspension of its midsize A6 wagon, adding some rugged body cladding, and calling it the allroad. A marketing twist in 2013 brought a downsized allroad that replaced the conventional Avant wagon in Audi's compact A4 lineup.
The allroad features a 2-liter turbocharged four-cylinder engine that generates 211 horsepower; an eight-speed automatic transmission sends power to all four wheels through Audi's iconic quattro system. Though boasting ground clearance of 7.1 inches, this crossover wagon isn't meant for serious off-road duty—and that's fine because a 0 to 60 mph time of 6.5 seconds means there's plenty of on-road fun to be had.


text:
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
Over the last few decades, multiple biological properties, providing antioxidant, anti-inflammatory, chemopreventive and anti-cancer benefits, as well as the characteristic pungent and bitter taste, have been attributed to Extra Virgin Olive Oil (EVOO) phenols. In particular, growing efforts have been devoted to the study of the antioxidants of EVOO, due to their importance from health, biological and sensory points of view. Hydrophilic and lipophilic phenols represent the main antioxidants of EVOO, and they include a large variety of compounds. Among them, the most concentrated phenols are lignans and secoiridoids, with the latter found exclusively in the Oleaceae family, of which the drupe is the only edible fruit. In recent years, therefore, we have tackled the study of the main properties of phenols, including the relationships between their biological activity and the related chemical structure. This review, in fact, focuses on the phenolic compounds of EVOO, and, in particular, on their biological properties, sensory aspects and antioxidant capacity, with a particular emphasis on the extension of the product shelf-life.
Several epidemiological studies have demonstrated that adherence to the Mediterranean diet can be associated with longevity and with a reduced risk of morbidity and mortality [
Several studies carried out recently have demonstrated that the healthy effects should also be attributed to the Olive Phenols (OP) of EVOO [
EVOO hydrophilic phenols represent a class of secondary plant metabolites demonstrating unusual sensory and health properties. Generally speaking, unlike lipophilic phenols, they are not found in other oils and fats [
Phenolic compounds in Extra Virgin Olive Oil (EVOO).
|Phenolic acids and derivatives
|Phenolic alcohols
|Vanillic acid
|(3,4-Dihdroxyphenyl) ethanol (3,4 DHPEA)
|Syringic acid
|Gallic acid
|Caffeic acid
|Protocatechuic acid
|Ferulic acid
|Cinnamic acid
|Benzoic acid
|Dialdehydic form of decarboxymethyl elenolic acid linked to 3,4-DHPEA (3,4 DHPEA-EDA)
|Dialdehydic form of decarboxymethyl etenolic acid linked to
|Oleuropein aglycon (3,4 DHPEA-EA)
|Ligstroside aglycon
|Dialdehydic form of oleuropein aglycon
|Dialdehydic form of ligstroside aglycon
Chemical structures and average values (mg/kg) of the prevalent phenolic alcohols, phenolic acids and secoiridoids of EVOO calculated using 210 oil samples obtained in industrial plants a [
|Chemical structure
|Vanillic acid
|Caffeic acid
|(3,4-Dihdroxyphenyl) ethanol (3,4 DHPEA)
|Dialdehydic form of decarboxymethyl elenolic acid linked to 3,4-DHPEA (3,4 DHPEA-EDA)
|Dialdehydic form of decarboxymethyl elenolic acid linked to
|Oleuropein aglycon (3,4 DHPEA-EA)
|Ligstroside aglycon (
a Unpublished results. The concentration of hydrophilic phenols was evaluated by HPLC as previously reported by Montedoro
As we pointed out before, secoiridoids represent the larger fraction of hydrophilic phenols in EVOO. In particular, their chemical structure is represented by the dialdehydic form of decarboxymethyl elenolic acid linked to 3,4-DHPEA or
The concentration of phenols in EVOO is strongly affected by agronomic factors, such as the area of origin, the cultivar, the stage of fruit ripening and also by several agronomic procedures and the technological, operative conditions of the oil extraction process [
In this perspective, studies involving humans and animals (
Antioxidants, as already mentioned, play a key role in the shelf life of EVOO due to their biological activity delaying oxidation processes. In this respect, the primary antioxidants inhibiting oxidation processes in EVOO are OP, which act as chain breakers by donating radical hydrogen to alkylperoxyl radicals, produced by lipid oxidation and the formation of stable derivatives during the reaction (
Mechanism of the antioxidant activity of Olive Phenols (Ops) on EVOO.
However, the same high antioxidant power of 3,4-DHPEA was also shown in an evaluation of the antioxidant activity of some specific hydrophilic phenols (3,4-DHPEA,
Furthermore, Carrasco-Pancorbo
The antioxidant power of lignans was recently studied by Owen
In 2007, hydroxytyrosyl acyclodihydroelenolate and
Very recently, several simulations of the behavior of EVOO during frying and other cooking processes have been carried out [
In this respect, Gomez-Alonso
On the other hand, both
Moreover, other authors measured the resistance to thermal treatments not only of some secoiridoids derivatives, such as 3,4-DHPEA, elenolic acid, 3,4-DHPEA-EDA and 3,4-DHPEA-EA, but also of lignans. The outcomes of the comparison indicated that lignans are the most thermal resistant compounds in the comparison and that the secoiridoids under examination deteriorated with the thermal treatment faster than other phenols of EVOO, such as 3,4-DHPEA acetate and
Over the last decade, many efforts have been spent on identifying the mechanism of the formation of acrylamide whilst frying amylaceous products. In fact, this compound has been classified as carcinogen and must, therefore, be monitored. However, its formation mechanism during cooking at high temperature is not completely clear, but from recent studies, it appears to be related to the Maillard reaction, involving amino acids and reducing sugars. In particular, they believed asparagine, the main amino acid in potatoes, to be its precursor [
As mentioned previously, the efforts spent in recent years studying EVOO phenolic compounds can be ascribed to the fact that these substances show many healthy benefits, including the reduction of the risk factors of coronary heart disease, the prevention of several chronic diseases (for example, atherosclerosis), cancer, chronic inflammation, strokes and other degenerative diseases [
A very important study recently carried out by Castañer
In 2010, two hundred, healthy, non-smoking males from six centers of five European Countries were involved in the EUROLIVE study. They were divided into three groups, each of which was fed 25 mL/day of raw EVOO with a high (366 mg/kg), medium (164 mg/kg) and low (3 mg/kg) phenolic content, respectively, in a randomized, cross-over, double-blind and controlled trial, with a Latin square for three treatments in the cross-over randomized trial. A two-week washout period was used before each EVOO intervention, whereas the intervention period lasted three weeks. They observed a decrease in lipid oxidative damage, in addition to an increase in the cholesterol level of High Density Lipoproteins (HDL), which are strongly dependent on the phenolic content of EVOO. Moreover, the increase in the dependent HDL level of OPs has been observed in other studies on humans [
Healthy properties of Ops.
The relationships between the positive effects on health due to OPs and maintaining normal blood HDL cholesterol levels were evaluated by the EFSA. However, there is a need for further experimental findings in order to assess this cause-and-effect relationship [
The fact that the functionality of the HDL should be more important than its amount in the blood has been the subject of recent studies. HDL functionality could possibly be related to the promotion of cholesterol efflux from macrophages in the so-called "reverse cholesterol transport" process [
Moreover, feeding 400 mg/kg of EVOO OPs has been proved to improve endothelial function in hypercholesterolemic patients in the postprandial state [
An improvement of the endothelial function was also observed by Moreno-Luna
The healthy effects of hydroxytyrosol [
Moreover, platelet aggregation, a key factor in the formation of thrombus and myocardial infarction or angina, has been proved to be affected by OPs. In fact, the activity of the EVOO phenol DHPE (2-(3,4-di-hydroxyphenyl)-ethanol) seems to interfere with 400 mM platelet aggregation
In the last decade, several studies carried out
The negative correlation of 3,4-DHPEA-EDA and
As regards lignans, pinoresinol appears to have an insignificant pro-apoptotic activity which, in any case, is sufficient to inhibit the proliferation of HL60 cells, when its concentration is of the order of 10–100 µM, even though its concentration in the phenolic extract was lower. On the other hand, although several studies have demonstrated the chemopreventive properties of 3,4-DHPEA in terms of its antiproliferative and pro-apoptotic effects, the effects of EVOO phenolic extracts on cancer cells are still unclear.
Phenolic compounds have recently been associated with the likelihood of preventing the risk of Alzheimer's disease and of reducing its related effects, although the mechanism by which the EVOO phenols exert their neuroprotective effects is not completely clear [
Abuznait and co-workers [
Finally, as regards the anti-microbial properties of phenolic compounds, it has been observed that the administration of EVOO phenolic compounds also affects the gut microbial balance, due to the fact that they are not completely absorbed into the upper parts of the gastrointestinal tract, whereas they are metabolized in the lower parts by the gut microflora [
The OPs of EVOO strongly affect its sensory properties. The fact that the EVOO phenolic fraction has a strong impact on bitterness, astringency and pungency has been the subject of several past studies [
In order to establish the correlation between the bitterness of EVOO and the related chemical compounds behind it, Garcia
Over the last decades, the fact that the attributes of the taste of EVOO had to be ascribed either to the total phenolic content of EVOO or to the lignans fraction, has been the subject of debate. Moreover, a statistical correlation between the total amount of secoiridoids and EVOO sensory responses, such as "astringency" and "bitterness", has been the subject of a certain number of studies. However, very little data identifying the chemical structures of secoiridoids and their taste attributes has been published.
Values of the six points adopted by the panel (Note: with permission from [
|Reference value
|Sensory attributes
|absence of attribute
|simple perception
|light presence
|middle presence
|strong intensity
|highest intensity
In this regard, many authors have hypothesized that the main contributors to the bitterness of EVOO are those compounds with an aromatic ring in their chemical structure, as in the case of the secoiridoid derivatives of oleuropein (3,4-DHPEA-EDA and 3,4-DHPEA-EA) [
Moreover, Gutiérrez-Rosales
A recent work by Andrewes
In 2005, Beauchamp
Recent investigations on
The EVOO quality is intimately affected by its content in phenolic compounds. In fact, the hydrophilic phenols influence not only its shelf-life but also its health and sensory proprieties.
The review has been focused on the evaluation of the antioxidant effects of OPs. In particular, the antioxidant activities and healthy properties of secoiridoids derivatives, such as 3,4-DHPEA, 3,4-DHPEA-EDA, 3,4-DHPEA-EA,
In recent years, the innovation process in the field of EVOO is being orienting towards a new concept of quality, strictly related to OPs content (which, more than other compounds, are affected by technological processes) to end of producing EVOOs characterized by a strong sensory impact and healthy benefits.
The authors wish to acknowledge the Consorzio Olivicolo Italiano UNAPROL—Italy (projects Reg. EC n. 2080/2005 and n. 867/2008) for the financial support.
The authors declare no conflict of interest.


text:
found a new home!
Plenty of my friends are looking
for one too. Find a pet to adopt.
I am already neutered, housetrained, up to date with shots, good with kids, and good with dogs.
THIS IS ROMEO....a sweetheart of a dog who is still trying to figure out where he is and why he's there! This gold/white, 4-5 yr old, 14.7 lb, wide-eyed Lhasa Tzu is a doll. He is now all settled in his foster home, after coming out of the shelter with pneumonia. The Baldwin Park Shelter called us and said he was going down if we could not take him...and we couldn't let that happen. He's all well now and has come of his shell. We originally thought he was older, but he has a very playful, joyful side of him. He is definitely a lap dog...and would do well in any household setting. He should go with another laid back but playful dog.......he loves other dogs and is just beginning to show a more playful side of himself. He even has the potty training thing down....but no guarantees at your house. Have some patience and a little refresher course and he'll surprise you! He's a good eater....Romeo isn't a big kisser...but he is very affectionate and interested and curious about the world. He would be a wonderful companion to anyone...even a semi senior home (still needs and loves to be walked) and kids over 8 yrs old would be fine. Romeo...Romeo...where art thou? AT LHASA HAPPY HOMES....COME AND GET HIM!!!
Our website is updated daily. Please do not apply for this dog unless your home fits the specified criteria. All of our dogs are spayed/neutered, microchipped, groomed, vet checked, dewormed, deflea'd and come with a leash, collar and ID tag!
If you are interested in adopting a pup from Lhasa Happy Homes, please complete the Adoption Application before calling. We want to give you the time you deserve, so please help us help you!! We will contact you once it has been reviewed.
Most Sundays, unless we are doing a special event, we are at My Pet Naturally (12001 W. Pico Blvd., West LA 90064) from 11a-3:30pm. You can see this, and many more, adorable pups at this weekly event! Please do call us if you are coming to see a particular dog to make sure he/she will be at adoptions (we do not bring sick dogs to our adoption events). Please bring a copy of your application and pictures of your home and yard if we have not done a home check! Most importantly, if you have a dog, make sure you bring him or her to do a compatibility match with the dog you are interested in adopting!!! And don't forget to check out our Events Calendar for more information on events we may be doing! See our home page for more details about our adoptions at Lhasa Happy Homes.
Thanks for thinking rescue and adoption....and for considering saving a life. It will be the best gift you ever give yourself or your family.
ROMEO, a Los Angeles Lhasa Apso/Shih Tzu dog was adopted! Here's how you can benefit by looking at adoption as an option to buying a Lhasa Apso/Shih Tzu for sale in Los Angeles, or seeking a Lhasa Apso/Shih Tzu dog from a breeder in Los Angeles.


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Spaniard Nani Roma moved into the Dakar Rally lead with victory in the third stage on Tuesday as favourite Stephane Peterhansel suffered a nightmare day.
Frenchman Peterhansel began the day in the overall lead following his victory in Monday's second stage, but had six punctures as he came home in 28th place, more than 28 minutes down on Roma.
In the overall standings, Roma leads a trio of Mini drivers with Argentine Orlando Terranova second and Nasser Al-Attiyah of Qatar third.
Peterhansel is down in fifth place overall but is 24min 08sec behind Roma.
And the 11-time former winner (six times in the moto section and five times in cars) admitted he had not enjoyed the 301km timed section from San Rafael to San Juan.
"I've never known a Dakar stage like this one," said a frustrated Peterhansel.
"It was a nightmare today. We punctured six times! Unfortunately, we opened on the course and we paid for it.
"On the first, I hit a big rock - that's my fault. But then we were the first to go out and we found ourselves completely off-piste in very tall vegetation thanks to a last-gasp swerve due to bad weather and mud.
"And when we got out of that, we had three slow punctures out of four wheels, certainly due to the pines in the sides of the wheels.
"Unfortunately, as we were the first car, we cleared the track for the rest behind. We were thrown into the lion's den but I can't see how we could have done anything differently.
"We couldn't have imagined that in clearing a path in the vegetation, we'd get three punctures out of four."
In the motorcycle section, Spaniard Joan Barreda on a Honda increased his overall lead by winning the third stage, a 292km timed special.
Frenchman Cyril Despres on a Yamaha came in second with Spain's Marc Coma third on a KTM.
Those three remain in those positions in the overall standings.


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Father: JOHN COOK b: 13 JAN 1630 in England
Mother: MARY BORDEN b: BEF 13 JAN 1633 in Kent County, England
Marriage 1 Ruth SHAW b: 10 OCT 1660
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Larger commercial, public, and industrial installations generally use three-phase supplies, with distribution boards which have twin vertical rows of breakers. Larger installations will often use subsidiary distribution boards.
In both cases, modern boards handling supplies up to around 100 A (CUs) or 200 A (distribution boards) use circuit breakers and RCDs on DIN rail mountings. The main distribution board in an installation will also normally provide a main switch (known as an incomer) which switches the phase and neutral lines for the whole supply. (n.b., an incomer may be referred to, or sold as, an isolator, but this is problematic, as it will not necessarily be used as an isolator in the strict sense.)
Older CUs
Recent (pre-17th edition wiring regulations) CUs would not usually have RCD protected sections for anything other than socket outlets, though some older CUs used RCD Incomers. Before the 1990s RCDs (and split busbars) were not standard in CUs.
RCD protection types
Fuse Boxes usually use cartridge or rewirable fuses with no other protective device, and basic 4-ways boxes are very common. Some older boxes are made of brown-black bakelite, sometimes with a wooden base. Although their design is historic, these were standard equipment for new installs as recently as the 1980s, so they are very common. Fuseholders in these boxes may not provide protection from accidental contact with live terminals.
The popular 4-way fusebox usually has two lighting and two socket circuits, with heavy or sustained loads such as immersion heater and oven on a socket circuit. This arrangement is not recommended practice today, as electricity usage has substantially grown in the last 20 years, but it is still in some existing installations. Larger boxes with more ways will have separate fuses for large loads such as immersion heater, oven and shower.
Circuit breaker retrofits
Some of these fuseboxes have had their fuse carriers replaced with plug-in miniature circuit breakers. These retrofit MCBs are typically rated at 3kA breaking capacity, but many homes or properties have prospective short circuit currents as high as 6kA. Fault currents of over 3kA are thus interrupted by the incomer fuse, should they ever occur, and the MCB would not survive.[citation needed]
Historic fuseboxes
A small number of pre-1950 fuseboxes are still in service. These should be treated with caution because exposed live parts are common on these boxes. The installations they supply will not meet modern standards for electrical safety. Another characteristic of very old installations is that there may be two fuses for each circuit; one on the live and one on the neutral. In rare instances, old ring circuits may be encountered with no less than 4 15 A fuses per ring, one on each of L and N, and this duplicated for each of the 2 feeds for the ring.
Inside a UK distribution board
This picture shows the interior of a typical 12-position UK distribution panel. The incoming live cable connects to the busbars via a main dual pole isolator switch on the left of the panel. This isolator switches both the live and the neutral feeds on and off at the same time. Power comes in to the top of the isolator and so out of the bottom must come twp cables to go behind the DIN rail and into the top of both RCD's. In this diagram the neutral comes out of the bottom of the isolator and into a central neutral terminal bar but often, just as the live, two cables will come out of the bottom of the isolator behind the DIN bar and into the top of the RCD's. Once the RCD's become live and they in turn are asitched on power comes out of the bottom of the RCD's and into the bus bars to which all the other MCB's are connected. The cables to the individual circuits are then fixed into to the top of the MCB's. In the finished consumer unit, even once the cover is removed there will be a plastic shield covering these bus bars so as to give extra protection.
Things to note.
The MCB's will be in descending order of value, i.e., 40amp, 32amp, 32amp, 16amp and a 6amp. And that the MCB's on the left hand side of the board will have their corresponding neutrals attached to the left of the two neutral bars. It is important to note that if you have even one of the neutrals from the left side going into the right hand bar the board will never power up properly and you will always have nuisance tripping if you can even get it to stay on for longer than a few seconds.
The incoming earth wire connects directly to the earth bar on the top right of our diagram to which all the other earths are connected to.
Spotlights / Lighting
Full / Partial Rewires
The life expectancy of a new electrical installation is approximately 20 Years. There are many factors that affect the life expectancy i.e. the type of wiring and how it was used. As the life of an installation is pretty long, it is easy to forget that it will eventually need replacing.
Contemplating a complete rewire is a huge undertaking but very worthwhile in updating your home electrics to meet current regulations and most importantly, safety standards. A rewire will also make the electrical wiring in your home more capable of meeting today's demands in terms of electrical appliances.
DJL Electrical can update all this for you in one go and will make the experience as stress-free as possible for you. We offer free no obligation quotations for work ranging from a full rewire to a selection of small alterations and repairs and all our work is fully certified.
Does your house need a rewire?
Many houses in the UK still have old wiring. This is not only unsafe and a potential fire hazard but is also less efficient than modern systems. It can also affect the resale value of your house, as old wiring almost certainly is highlighted as a major problem during a survey.
If you have old wiring in your house, for example fabric or rubber covered flex you should seriously consider having a complete rewire.
Here at DJL Electrical we can completely redesign your electrical system to include sufficient socket outlets located in the right places to accommodate your needs, a state of the art consumer unit to replace your old fuse box which will contain residual current devices and circuit breakers. Rewiring a house is a major undertaking, but rest assured we will carry out the work as quickly and efficiently as possible.
A full rewire involves replacing all cables, fittings and distribution equipment. Cables can be chased into the walls & completely hidden. Alternatively a rewire can involved a surface rewire where the cables are hidden in mini trunking fitted onto the surface of the walls.
A part rewire may be the replacement of a section of the installation or just updating of the fuse boxes, fittings or cables to upgrade an installation to the current regulations and efficiency.
It is helpful if you consider rewiring your home before you undertake a lot of decorating as creating new sockets and moving lights and switches does create mess and often redecorating becomes necessary in some rooms.
Some customers ask how they should prepare their home in advance of our arrival. Obviously the easiest time to have a rewire is before you move in! However, if you are living in the property it helps if you can reduce general clutter and large items of furniture are moved a short distance from the wall.


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BMW Masters: Gonzalo Fernandez-Castano relieved after nervy finish in Shanghai
Gonzalo Fernandez-Castano was relieved to have a three-shot lead at the last after clinching the BMW Masters title.
Last Updated: 27/10/13 2:07pm
The importance of the Spaniard's chip-in for an unlikely birdie at 17 became apparent when he found sand twice en route to a scrappy double-bogey six at the closing hole.
His tee-shot found a fairway bunker, and he blocked his third into a greenside trap to raise the possibility of a play-off with the fast-finishing Francesco Molinari.
But Fernandez-Castano splashed out to six feet and calmly two-putted to seal a nerve victory in the opening event of the inaugural European Tour Finals Series.
"I knew it wasn't going to be an easy round, especially the way I started," said Fernandez-Castano, who parred the opening six holes before settling his nerves with birdies at seven and eight.
"I started hitting the ball pretty bad but my caddie kept me cool and told me how good I had been hitting the ball through the week and I played fantastic after that.
"On the last I played too conservative and it was a fighting six at the end for sure. I am glad I had a three-shot advantage on the last because I made my life a little complicated on that hole.
"The putting was letting me down a bit but I made a few changes with my coach last week and it has paid off.
"It's perfect timing because it's Ryder Cup qualification period right now. It doesn't get any better than this; first event of the first ever Final Series and I got the victory."
Molinari was six shots off the pace at the start of the day and despite a front nine of 34, his chances looked to have disappeared with a bogey on the 12th.
But the Ryder Cup star eagled the next and then carded four consecutive birdies as he closed with a superb 64 to set the clubhouse target at 10 under par.
"I haven't played really well on the back nine this week, I always got off to a good start and was stalling on the back nine," said the Italian.
"It was another good start today, then I three-putted the ninth and I thought maybe I get everything back on the back nine.
"I made a good birdie on 11, three-putt on 12 again from far away and then hit a great shot on 13 to make eagle and from then on it seemed everything was going in.
"It's a great feeling when you get to play nine holes like that."


text:
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the support from the French forwards came thick and fast and it was a great line and UA ClutchFit Drive II Shoes to put the second row in at the corner.Indian Home Minister Admits 'Small' Number of Indian Youths Joining ISIL Sputnik InternationalIndian Home Minister Admits 'Small' Number of Indian Youths Joining ISIL REUTERS Thaier Al-Sudani Iraqi Militias Destroy Civilians' Homes Following Operation Against ISILNEW DELHI (Sputnik) India's junior home minister and lower house of parliament member admitted Wednesday that a number of India's young population are fighting alongside the extremist Islamic State group. No stunt plane can take your breath away like this.
March 16 -UA ClutchFit Drive II Shoes is arrested,Its limited edition watches use tiny reservoirs of coloured oil and water that are forced into thin tubes, and another who asked for his name to appear on the parts.2 years, As of January 2015, slotting a penalty following a scrum infringement.when we did, Last week, those boys had not been accounted for, "We had a lot of clear chances but the keeper had a brilliant game." Former Barcelona striker Gary Lineker and current Barca boss Luis EnriqSue also heaped praise on Hart. activist Cindy Sheehan," said Sheehan, The two ships will depart on March 27. And in barely two years we will see UK carrier steel here too.


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Joe Strummer said the future is unwritten. For The Gaslight Anthem, it's Handwritten.
The New Jersey heartland punks' fourth album marks some major turning points for the six-year-old band — and its title reflects how it was conceived and crafted, says frontman Brian Fallon.
"I really did write the lyrics in a notebook; they were all literally written by hand," explains the 32-year-old singer-guitarist. "Around the time I started writing these songs, a friend of mine gave me a letter and a poem he wrote. And that just sparked me; what if a record was a letter sent straight to the listener? It hit me that it was the most heartfelt thing I could do."
It's just one example of how the critically respected band — which also includes guitarist Alex Rosamilia, bassist Alex Levine and Benny Horowitz — has become more hands-on and direct in both its music and career. With Handwritten due Tuesday July 24, there's no better time for us to count the ways life had changed for The Gaslight Anthem lately:
1 | They wrote these songs together
On the band's first three albums — Sink or Swim (2007), The '59 Sound (2008) and American Slang (2010) — Fallon was chief songwriter, bringing fully formed tunes to be fleshed out by the band. Not this time. "I refused to do that anymore," he says.
"That is not how bands operate, and we're a band. I had to say, 'You guys need to start writing with me, or else it's the Brian Fallon show, and that's not what I want … Either we're going to do this a new way or I'm out.' " The transition wasn't easy — the band penned nearly 50 songs for Handwritten — but having everyone chip in paid off, he believes. "It sounds more unified. Not to say anything bad about our previous records, which I love. But at this time in my life, I need something different."
2 | Fallon's lyrics are more revealing
Along with asking more of his bandmates, Fallon also challenged himself, stepping out from behind the narratives and pop-culture references that usually characterize his lyrics. "There's no guard this time — no more stories, no more characters, no more New Jersey, no more nothing. Whatever I feel in my heart is going straight on the page. Because that's what matters to a kid who's listening, and what matters to me when I'm singing it every night. So I'm throwing it all out there." This transition was easy, he insists. "It's really freeing. I feel like a weight has been lifted off. Because people compare us to other bands constantly, but my story is not anyone else's story. So you can't compare that to anything."
3 | They worked with Brendan O'Brien
Speaking of comparisons: Fallon knows that hiring superstar studio whiz Brendan O'Brien — co-producer of four Bruce Springsteen albums — will only reinforce the belief that he's got a serious Boss fixation. "Yeah, I knew people were going to say we did it because Bruce Springsteen did it; apparently I also eat eggs in the morning because Bruce does. That's a total joke. I'm from New Jersey; I know the guy; I'm the Springsteen expert. I'll tell you when I'm copying him and when I'm not." Truth is, he was actually copying Pearl Jam. "I skipped class to go buy Vs. the day it came out in 1993," he says. "This is a guy who shaped our lives when we were kids growing up listening to grunge. Plus he's the best musician I ever met in my life."
4 | They're playing in the big leagues
Getting O'Brien is only one of the benefits of the band's new major-label deal, which comes as the music biz implodes and artists trumpet DIY as the future. Fallon knows he's swimming against the hipster tide.
His response: So what? "We've never cast ourselves as this DIY punk band. We've never championed that cause. We've always said we were a rock 'n' roll band and if people like us and we get big, that's awesome. I'm not going to say no because of what somebody thinks. And so far, we haven't done anything we didn't want to do." So we won't see him in a spangly jacket on American Idol? "No, I'm doing that next week," he cracks. "When they brought that up, I said, 'Spangly jacket? Yeah!' Why wouldn't I do that?"
For the record: That was sarcasm.
5 | They don't care what you think
Fallon's defiance mirrors the most crucial change to the GA's MO: They've stopped paying attention to what anyone says. Fallon no longer reads interviews like this. He no longer lets his heroes influence his work. He doesn't care how many online followers or friends he has.
"We've been a band for so long, and we spent so much time defining who we were and where we came from and blah blah blah," he says. "Well, I've decided that my life is not going to be dictated to me by what's going on outside of my world. I don't do this for everybody else. I do this for the kids who listen to our band, and for us — mainly for us. This is something we're chasing. So I'm just going to put my head down and keep moving forward." Into the unwritten future.


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Get SEVEN PotPieGirl Strategy Guides for one Crazy-Low Price!
Get Details Here
Even though the migration of eBay links has been extended until May 31st, I still went ahead and changed out all my Squidoo lenses that had the eBay RSS affiliate feeds with the new eBay Partner Network tracking. Now, let me be clear right up front, I don't make a 'killing' off eBay affiliate sales, but I had gotten fairly used to daily sales activity when we were with Commission Junction.
I changed out these links to start May 1st. While I've seen steady impressions and clicks… I wasn't seeing any sales. I was getting concerned. Today, I logged in to my EPN affiliate account and saw that finally, I'm making sales again. I also scooped an ACRU – which pleases me =)
How do You Figure Out WHAT You Sold as an eBay Affiliate on EPN?
While we were with cj, you could download a csv file and put it into one of those online tools to figure out exactly what you sold with your eBay affiliate links. The new ePN links, tho, don't appear to work there anymore.
I wanted to know what I sold to make that commission, so I thought I'd play with the affiliate reports some and see if I could figure it out. Many of you may already know this, which would be par for the course in my world… I'm always last to know…lol.
So, if you know this, just ignore me. If you don't … keep reading!
6 Steps to Figure Out eBay Affiliate Sales
Step 1. Log In to your ePN affiliate account.
Step 2. Click "reports"
Step 3. Click "Transaction Download"
Step 4. Select date range
Step 5. Click "Download Text File"
This will open in a .txt notepad file and will look like this:
As you can see, I had commissions from two winning bids, and an ACRU (new user bonus). On the left side going down, you see a date, under that is my account number (blurred out) and then under that is a long number (which I am pointing to with my fancy-dancy red arrows…lol).
Step 6. Highlight that auction ID, paste into eBay search tool, and click 'search'.
If you highlight and copy that number on my EPN transaction download – and then enter that exact number right into the ebay.com search bar, the auction my customer won is shown =)
In my example, for auction #370048371222, my customer bought two Aeron Office chairs at $579.00 each (hence the 1158.00 amount you see to the right of my transaction download). Nice!
While this is far from a high-tech and sophisticated way to find out what you've sold on eBay, it works… and it's quick.
How Often Does eBay Report Sales to Affiliates?
This was my other question – how long does it take for sales and ACRUs to show in our affiliate area after an auction is won? From this eBay forum post, I learned that clicks and impressions are reported within 4 hours. Winning bids and ACRUs are reported and shown on the eBay affiliate's dashboard by midnight of the following day.
So folks, we're not 'real time' in our eBay/EPN affilate stats, but at least that is an answer, right?
Edit to Add (5-14-2008) – I just knew that sooner or later, someone would make a tool (or ten) that would make finding out what you sold thru your eBay links a bit easier. Sure enough, I found two new tools today.
MyEPNReport.com – (web-based) New tool. Simply download your sales report as shown above and then upload it to the MyEPNReport.com tool. It will then show you what you sold and how much the auction was won for. I've tried it and it appears to be accurate.
TropicalWebWorks.com – This is an EPN report tracker script/program that you host on your own server. I haven't even tested it yet, so I don't have feedback on it at this moment. I'm interested to try this one out.
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The two were seen at a nearby bar, where he purchased two Beers.
Since I was paying three thousand for the Beers, I worked out that sixty thousand must have been about US$20.
I went back home to bed in the morning, green in the face after what seemed like 20 joints and 700 Beers.
If they were not working, they would be sitting on a bench and easily down three to four Beers an hour.
Enjoy its wide selection of Beers to kick off a night of fun.
The per-centage in English Beers of malt extract (dextrin and sugar glucose) is least in bitter, and highest in the sweet ales.
"Step up for your Beers, gentlemen," cried the bartender at this moment.
So Beers became wildly jealous and indignant, and left her for good.
The Beers were a gifted family, running out in different directions.
I drop a glass I'm so surprised, but I give him two Beers like he wants.
Old English beor "strong drink, beer, mead," a word of much-disputed and ambiguous origin, cognate with Old Frisian biar, Middle Dutch and Dutch bier, Old High German bior, German Bier.
Probably a 6c. West Germanic monastic borrowing of Vulgar Latin biber "a drink, beverage" (from Latin infinitive bibere "to drink;" see imbibe). Another suggestion is that it comes from Proto-Germanic *beuwoz-, from *beuwo- "barley." The native Germanic word for the beverage was the one that yielded ale (q.v.).
Beer was a common drink among most of the European peoples, as well as in Egypt and Mesopotamia, but was known to the Greeks and Romans only as an exotic product. [Buck]They did have words for it, however. Greek brytos, used in reference to Thracian or Phrygian brews, was related to Old English breowan "brew;" Latin zythum is from Greek zythos, first used of Egyptian beer and treated as an Egyptian word but perhaps truly Greek and related to zyme "leaven." French bière is from Germanic. Spanish cerveza is from Latin cervesia "beer," perhaps related to Latin cremor "thick broth."
Related Terms
cry in one's beer, drink one's beer, sling beer, small potatoes


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I'm kinda siding with ovi here. Maybe grab a playmaking WR like evans or watkins at 15, if they are even available there.
then try to fix the defense 2-5.
I'm certainly no scout and nix may turn out to be dominant, but the several times I watched ND, I just wasn't overly impressed.
what CB do you see worth 15?
seems to be a pretty weak at CB and S at the top of the draft unfortunately.
I honestly think that NT is the #1 thing we need if we continue to run the 3-4. McClendon simply didn't get it done this year. He moves too much and and shoots gaps trying to get upfield instead of standing his ground, and holding blockers. He ran himself right out of the play so many times this season, leaving the middle of the field vulnerable, and it was exploited by backs and even QB's on several instances. I agree with the premise of releasing Hood and keeping McClendon as the left DE. He penetrates well and that's good for a DE, not a 3-4 NT. Perhaps that was plan all along, until Ta'amu's antics cost him the potential NT job. If Nix is there, you take him. An elite NT in this system instantly makes your MLB's better, and they are already pretty good, and add to that you have Spence coming back next year - an elite NT will turn him loose to do what he does best, RUN to the ball carrier. I think we can pick up some secondary help in later rounds. I think we go NT, WR, and start plugging holes from there.
First rule of the NFL draft: your 1st round pick had better be a 'can't miss' prospect. Seems there are enough questions on Nix the team might want to think twice.
Haven't spent a ton of time on this draft class, so i can't even say who the can't-miss prospects are.


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Students from across North America compete in Alpaca Textile Design or Alpaca Fashion Design every year in the AOA Student Design Competition.
AOAs award winning publication. Delivered to Association Members 4 times per year. Available digitally to all Registry & Association Members.
Thank you to all of our National Sponsors. We couldn't do it without you!
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Fleece Show, Education, Photo Contest Winners, Student Design Contest Winners, Fashion Show, and more will be at this years AOA National Fleece Conference.


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Have Medical Questions? Ask a Doctor Online!
hi amelia,
welcome to justanswer and thanks for your question,
whats your age?
since when you have this problem?
do you suffer from frequent costipations?
bleeding related with passage of stool?
since how long you have this problem?
past history of hemorrhoids?
Problems started in Sept. 2008
No- I do not suffer from severe constipaption.
No- Bleeding is not observed in the stool. Bleeding occurs when itching the area around the anal sphincter.
No- Hemorrhoids.
Have tried topical treatments, pinworm medication, calymine lotion, backing soda, wiping with baby wipes, drying with blow drier to reduce moisture, fungal treatments, hydrocortisone, dermaplast, preparation H, vasoline, benedryl, antihistimines, antacids.
have you consulted doctor regarding this problem?
any tests done(stool test for parasites)
I have consulted a doctor twice. One treatment was for pin worms. The second treatment was for fungal issues. I have another appointment tomorrow.
No - I have not had my stool tested for parasites.
are you taking any antibiotic medication for some other illness ?
frequent laxative usage?
history of yeast infections ?
scented or color toilet paper usage?
No antibiotic meds.
No laxative use.
No history of yeist infections.
No color or scented toilet paper.
let me explain like this for you Amelia.
Anal itching also called as pruritus ani,and it has many causes,
First of all let me list all the causes so that you should know what possible reasons can be.
Dry skin(excessive washing with soap or age related)
Chemical irritants ie soaps,colognes,douches,colored or scented toilet paper etc
Hot sausy foods or foods with some chemicals.
Medications ie some antibiotics can cause such problems
Overusage of laxative medications
Infections ie STD sexually transmitted diseases or parasitic causes ie pimworms
Yeast infection may also cause itching
Frequent constipations or forced bowel passing may result in minor abrasions or tears that can result in anal itching
Anal tumors,
As a rule treating underlying cause is the baseline treatment in relieveing from symptoms of anal itching, proper clinical examination by your doctor or proctologist is necessary,
My advice to you!
Bleeding in your case may be due to abrasions,so a proper clinical examination by your doctor is must.
Use of any OTC medication is not recomended for anal itching unless directed by the doctor ,creams or ointments can worsen the situation and help in progression of itching,irritation thus contributing to the present problem (i suggest you to stop using OTC products)
Avoid touching or scraching the affected area this will not help but can produce small abrasions and thus inflamation.
Stool test for parasites is must in your case.(i hope tomorrow doctor will suggest that)
Since you are having this problem from sept 2008, and its bleeding sometimes, in addition to baseline therapy(ie directed towards the main cause) a symptomatic therapy is required ,that may include anti-inflamatory agents ,and if suspected yeast infection then antimycotic therapy will be required on prescription of your treating doctor.
I give you a link by specialist of Mayoclinic with recomended treatment options and prevention methods and home remedies for your problem.PLEASE READ THROUGH.
i hope this information will be useful
If my answer has provided you with some good insight today, please click ****"ACCEPT"**** and I will receive proper credit for my time and effort, otherwise, JustAnswer.com will hold your deposit. Before leaving feedback, please let me know if you need clarification or more info.Bonus will be highly appriciated


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job noun (EMPLOYMENT)
A1 [ C ] the regular work that a person does to earn money工作;职业;职位
When she left college, she got a job as an editor in a publishing company. 大学毕业后她在一家出版公司当编辑。
It's very difficult trying to bring up two children while doing a full-time job. 一边抚育两个孩子一边做全职工作很困难。
After a disastrous first month in office, many people are beginning to wonder if the new president is up to (= able to do) the job. 由于任职的第一个月表现很糟,许多人开始怀疑新总统是否胜任。
More examples
- I've applied for an office job I saw advertised in the paper.
- How is Mary enjoying her new job?
- It's a tragedy that so many young people are unable to find jobs.
- The company plans to shut down four factories and cut 10 000 jobs.
- Increasing the number of women in top management jobs will be a slow process.
job noun (PIECE OF WORK)
A2 [ C ] a particular piece of work(一件)工作,活儿,活计
job noun (RESPONSIBILITY)
B2 [ S ] something that is your responsibility职责;任务
[ + to infinitive ] She believed her job as a politician was to represent the views of her party and the people who voted for her. 她认为自己身为政治家就是要做她的政党和选民的代言人。
More examples
- It's my job to keep a check on stock levels.
- It is the job of the inspectors to enforce compliance with the regulations.
- I don't envy you the job of cooking for all those people.
- Whose job was it to bring the tickets?
- It was my job to make sure there was enough food to go round.
job noun (PROBLEM)
job noun (EXAMPLE)
job noun (CRIME)
› [ C ] slang a crime in which money or goods are stolen, or an action or activity that is dishonest or unpleasant犯罪行为;勾当;伎俩
US He really did a job on her, telling her that he would always love her and then moving to Fiji with someone else. 他的确耍了她,告诉她自己会永远爱她,后来却和别人一起跑到斐济去了。
See also


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Rate decisions
Next week sees a host of central banks vote on monetary policy.
The Reserve Bank of Australia's board is expected to hold rates on Tuesday. On Wednesday Sweden's Riksbank, the National Bank of Poland, the Bank of Japan and the Bank of Canada are all set to vote. Read more


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My brother, Stuart Tocher, who has died suddenly, aged 38, from cardiac sarcoidosis, was a gifted climber and all-round adventurous spirit. Having experimented with windsurfing, hang-gliding and snowboarding in his early 20s, he was introduced to rock climbing and it soon became his passion.
Born in Aldershot, Hampshire, he spent his working life as a highly skilled vehicle technician, working at various times on Honda, Citroën and Fiat cars (one year, he reached the British final of Fiat's top technician award). But he lived for his climbing and most weekends he would be off to places that offered fresh challenges: the Peak District, the Avon and Cheddar Gorges, Snowdonia, the Wye Valley, and especially to the sea cliffs near Swanage in Dorset (where he tackled climbs with names such as Hangover, Resurrection and Old Lag's Corner – and enjoyed cream teas in the local tearoom).
It was on trips abroad that he truly excelled and he climbed regularly in the French and Swiss alps, conquering, among other peaks, Piz Badile, Mont Blanc, the East Ridge of Aiguille du Chardonnet, the Dent du Géant, and the Contamine-Mazeaud Route on Mont Blanc du Tacul (an ice-climbing classic). Other trips saw him bouldering at Fontainebleau, climbing the Calanques (the sea cliffs of Marseille) and, only last December, trying new climbs in the Costa Blanca, Spain. One of his finest achievements was climbing in the beautiful Tuolumne Meadows, near the Yosemite Valley in California, where Cathedral Peak (including Eichorn's Pinnacle) was successfully tackled.
But Stuart was no solitary man of the mountains: he partied as hard as he climbed, was extremely gregarious and had the ability to make anyone laugh. He never married, but spent 14 years with his ex-partner, Lea, and was very proud of the role he played in helping to bring up her two children, Danny and Sabrina. He spent his last 18 months in Fareham, Hampshire, where he was happy socialising and passing on his climbing skills to younger friends.
On the Saturday before what would have been Stuart's 39th birthday, 31 of his friends and family members (and two dogs) hiked to the summit of Snowdon. Apparently the weather had been bad up there for months, but by the time we reached the summit, the sun had come out for us to toast Stu with a can of Guinness, his favourite drink, and eat a slice of birthday cake. He is survived by myself, our sister Janice and parents, Marion and Tom.


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STATEMENTS ON INTRODUCED BILLS AND JOINT RESOLUTIONS -- (Senate - September 29, 2006)
By Mr. ALLEN (for himself and Mr. Warner):
S. 4045. A bill to designate the United States courthouse located at the intersections of Broad Street, Seventh Street, Grace Street, and Eighth Street in Richmond, Virginia, as the ``Spottswood W. Robinson III and Robert Merhige Jr. Courthouse''; to the Committee on Environment and Public Works.
Mr. WARNER. I rise today to join my colleague from Virginia, Senator ALLEN, in offering a bill to name the new Richmond Courthouse for two distinguished jurists and sons of Virginia.
We are privileged in the Commonwealth to have a long history, beginning with Jamestown as the first permanent English settlement on the American Continent. As a young republic, the College of William and Mary was selected as a site for the Nation's first law school.
The two men to be honored in the naming of the new U.S. Courthouse in Richmond were lawyers who throughout their careers adhered to the principle of ``equal justice under law.''
Spottswood William Robinson, III was born in Richmond, VA on July 26, 1916. He attended Virginia Union University and then attended Howard University School of Law, graduating first in his class in 1939 and serving as a member of the faculty unti1 1947.
Judge Robinson was one of the core attorneys of the NAACP Legal Defense and Educational Fund from 1948 to 1960, achieving national prominence in the legal community with his representation of the Virginia plaintiffs in the 1954 U.S. Supreme Court case Brown v. Board of Education. Brown outlawed public school segregation declaring ``separate but equal'' schools unconstitutional.
In 1964, Judge Robinson became the first African-American to be appointed to the United States District Court for the District of Columbia. In 1966, President Johnson appointed Judge Robinson the first African-American to the United States Court of Appeals for the District of Columbia Circuit. On May 7, 1981, Judge Robinson became the first African American to serve as Chief Judge of the District of Columbia Circuit.
Judge Merhige was born in New York in 1919 and he attended college at High Point College in North Carolina. He earned his law degree from the T.C. Williams School of Law at the University of Richmond, from which he graduated at the top of his class in 1942.
From 1942 to 1945, Judge Merhige served in the United States Air Force and practiced law in Richmond from 1945 to 1967, establishing himself as a formidable trial lawyer representing criminal defendants as well as dozens of insurance companies.
On August 30, 1967, Judge Merhige was appointed U.S. District Court Judge for the Eastern District of Virginia, Richmond Division by President Lyndon B. Johnson serving as a Federal judge unti1 1998. In 1972, Judge Merhige ordered the desegregation of dozens of Virginia school districts. He considered himself to be a ``strict constructionist'' who went by the law as spelled out in precedents by the higher courts. In 1970, he ordered the University of Virginia to admit women. As evidence of Judge Merhige's ground breaking decisions, he was given 24-hour protection by Federal marshals due to repeated threats of violence against him and his family. His courage in the face of significant opposition of the times is a testimony to his dedication to the rule of law.
Senator ALLEN and I carefully took this responsibility in naming the U.S. Federal. Courthouse in Richmond. We worked on it for several years and consulted the Virginia Bar Association and sought the views of the bench and bar. The Virginia Congressional delegation, the Virginia Bar Association, the Mayor of Richmond, and many others decided that the best way to honor both men was to have them equally share the honor of having the courthouse so named. I attach a letter from the former Virginia Governor, the current Mayor of Richmond, L. Douglas Wilder. I value greatly the views of a friend and fellow public servant and one who has joined me on many issues to benefit the people of Virginia.
I thank the Senate for the consideration of this bill and look forward to working with my colleagues seeking its passage.
Mr. ALLEN. Mr. President, I am pleased to join with my colleague the Senior Senator from Virginia JOHN WARNER in introducing legislation to name the new Federal courthouse in Richmond, VA for two great men and leaders of the civil rights movement, Spottswood W. Robinson III and Robert Merhige, Jr.
Judge Spottswood Robinson was a brilliant champion of civil rights for all Americans. As a student at Howard Law School, Judge Spottswood W. Robinson III earned the highest GPA ever achieved at the law school. Following law school, he returned to Richmond, VA to establish a law firm with another pioneer of civil rights, Oliver W. Hill. Through the years he was involved in many important civil rights cases in State and Federal courts, but it was his vital role in the seminal case of Brown v. Board of Education that placed Judge Robinson into legal history. Judge Robinson is widely recognized as the architect of the legal strategies that led to success in intergrading the nations public schools.
Judge Robinson left the private practice of law in 1960 to become Dean of the Howard Law School. In October 1963, President Kennedy nominated him to become a District Court Judge for the District of Columbia. Subsequently, Judge Robinson became the first African-American to serve as a Judge on the Court of Appeals for the District of Columbia and in 1981 became the Chief Judge for the Court. Upon retiring from the Court in 1992, Judge Robinson returned to his home in Richmond and continued to be an active member of the community until his passing in 1998.
The other fine jurist who the new courthouse in Richmond will be named is another hero of the civil rights movement, Judge Robert R. Merhige, Jr. Judge Merhige served this country for 31 years on the bench and as a member of the United States Army Air Force as a B-17 bombardier. Born in 1919, Judge Merhige attended the T.C. Williams School of Law at the University of Richmond, from which he graduated at the top of his class in 1942. Over the next 21 years, Judge Merhige tried hundreds of both criminal and civil cases in both State and Federal court. He served as President of the Richmond Bar Association from 1963 to 1964.
In 1967, President Lyndon Johnson appointed Judge Merhige to be a United States District Judge. Respected and admired by lawyers from coast to coast, Judge Merhige became known for his integrity and intellect. Despite the personal hardship placed on both himself and his family from those who disagreed with his rulings to enforce civil rights law, Judge Merhige continued to uphold the law and follow the constitution in the face of grave threats.
In deciding whom to name this courthouse after, I have taken great care to listen to all Virginians after securing funds for this impressive courthouse for downtown Richmond and its revitalization. I have worked with the Virginia Congressional delegation, the distinguished Mayor of Richmond, L. Douglas Wilder, State Senator Benjamin Lambert, the Virginia Bar Association, the Richmond Bar Association, and many others.
I am honored to join with my colleague Senator WARNER in ensuring that when people walk by the new Federal courthouse, they are reminded of these two distinguished jurists who helped change the face of society for the better with equal justice for all.


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Victoria Arlen's life drastically changed in 2006 at the tender age of eleven when she developed two rare conditions known as Transverse Myelitis and Acute Disseminated Encephalomyelitis. This was an incredibly rare scenario and Victoria quickly lost the ability to speak, eat, walk and move. She slipped into a vegetative state in which doctors had written her off as a lost cause. Victoria spent nearly four years "locked" inside her own body completely aware of what was going on just unable to move or communicate. Doctors believed there was little hope of survival and recovery was unlikely. Victoria, however was not ready to give up. In 2010 after almost four years she began the nearly impossible fight back to life. Learning how to speak, eat and move all over again.
Victoria went on to exceedingly defy the odds and not only recovered but has since become an accomplished Motivational Speaker, Actress, Model, and Swimmer. Her swimming resume includes three Silvers and a Gold medal from the London 2012 Paralympic Games as well as multiple World, American and Pan American Records.
In April 2015, Victoria made the transition from professional athlete to sportscaster and joined ESPN as one of the youngest on air talents hired by the company. Reporting for espnW, X Games and Sportscenter across all platforms. Victoria has become world famous not only for her story and accomplishments but for her message: "Face It, Embrace It, Defy It, Conquer It".


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Saturday, June 6th is the day all your dreams will come true. Assuming you have only one dream, and that dream is to meet Jon Adams. And assuming you'll be in New York City attending MoCCA, because that's where Jon will be, probably spending most of his time around the Indie Spinner Rack table.
Also, debuting at MoCCA will be Top Shelf and Indie Spinner Rack's Awesome 2: Awesomer anthology, which Jon designed. It's 208 pages of comics with a Jeff Smith cover and mini comic inside. And if you're determined enough, the whole thing is edible.


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os x "Swiss Army knife for QuickTime" Perian turning off the lights
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Ironically, the closing of City Hospital was beneficial to the Family Health and Social Service Center in providing the opportunity to acquire increased and renovated space as well as recognition of its crucial role in the Main South neighborhood. But, what were the long term effects on the residency program? It can be argued that although the residents lost a battle, Family Medicine in Massachusetts finally began to win the war. For one, by 1978 the residency program "home" was no longer at City Hospital, but had been integrated into the medical center itself, a prerequisite to a fuller integration of the specialty into the medical school's clinical, educational, research, and administrative structures. As a sign of the program's coming-of-age, in 1979 a residency program director with responsibility for all program sites was hired. Dr. Dan Lasser (who became chair of the department in 1998) vividly recalled the spirit of participatory democracy, social activism, shared responsibility, and just plain self-assertiveness that characterized the residents he encountered at his first interview:
[In 1979] I put together a little talk on quality assurance - I figured these kids don't know anything about quality assurance. I'm only two years older than them. They told the residents, this guy is coming, and he's going to be the residency director, and you get a chance to interview him. And their point of view was, we just came off a strike. We don't want anybody from the medical school telling us what to do. The medical school is an evil empire that doesn't want to put any money into this program. We were just based at City Hospital, they made us move to UMass Medical School, although the rotations moved to Hahnemann Hospital and to Memorial and to Holden Hospital, so we don't want any top down administration for this thing.
It was a very collaborative environment. One of the prime contacts I had then was a fellow named Jeff Modest, who had just organized a thing that he was calling a residency executive committee, which was like a management board, which was going to be 50% faculty and 50% residents, 25% central administration and 25% each of the health centers. It was democratic to the nth degree, no matter how you sliced it and diced it, it was representative. And one of the questions was will the new residency director come in and endorse the notion of having an executive committee? And I didn't meet many of the other faculty. The few faculty I met were basically saying to me, "Would you please come and take this job? Please?"
So I went to this residents' meeting and I brought my overheads and I was prepared to talk to them about quality assurance and they said, you're not here to give a talk, you're here for us to interview you, and they grilled me, they absolutely grilled me—will you do this, will you listen to us, and will you endorse this new executive committee. And I remember walking out of that meeting and Jan Albrecht, who was the administrative director of the program said to me, "I'm so sorry - you're probably going to walk out of here and never talk to us again." And I said, "No, this is really a fun group of people, this is great! Yeah, I'll take the job."(109)
When the medical school in 1981 tried to use the residency as a pawn in its budget battles with the Massachusetts legislature, residents like Dennis Dimitri, as we have seen in Section II, were empowered by their shared experience and culture to go directly to the Chancellor and ask: "Why?"
By 1984, ten years after the start of the program with the original four residents, 86 family physicians had graduated from the three Worcester program sites and the Fitchburg site. From 1976 until 2005, according to a recent study by Ferguson et al, 454 residents have graduated from the Worcester program, of whom 47.6% are women, 52.4% men. Ethnically, the program is representative of Massachusetts's largely white population: 87% of graduates are white, 5% Asian, 3.8% Hispanic, and 3.2% African American. Two-thirds of all residency graduates still practice in New England, with half of all graduates remaining in Massachusetts in particular. Strikingly, the study indicates that the patient characteristics of residency graduates today vary minimally from the characteristics of their original residency training site.(110)
The words of some of those graduates might best sum up the powerful role the program has played in the formation of these physicians and why Family Medicine residents stood at the forefront of community activism in Worcester to defend locally accessible, community-engaged health care for all citizens, even the newest and poorest of the city. Today, when primary health care is under renewed pressure to see more patients with a shrinking pool of family physicians, these core values remain vital to the task of encouraging more young physicians to pursue this medical pathway.(111)
I think this has been a very rewarding professional life. There's always little things that we'd all do differently, but big picture-wise, I can go to sleep at night feeling totally comfortable about the fact that I did the right things in terms of my career choices, both for me personally as well as being able to say that I think I did the right thing in terms of whatever socially-motivated reasons one would have behind some of the choices you make. That's a nice feeling to be able to have. You know, the trite way it's often put is to be able to "do well by doing good," but I think there's a lot of truth to that. You can do a lot of good as a family physician and generally speaking you'll still do well by yourself too. So as a career I would certainly continue to encourage it. - Dennis Dimitri
[The residency] did set the groundwork for a lot of the work I did later on, which included many home visits, active participation in end of life issues, and helping people transition in a non-medical way. Generally being more engaged I think with people's social settings and personal lives than the conventional model would have us believe is proper and appropriate. In fact that's always been one of my fondest memories of medicine, the home visits at 3 a.m. for the dying patient, or attending the funeral for the patient down south that went on for three hours, and on and on. That makes it a broader social context and it really kind of keeps it real. De-industrializes the process which everyone else—all the MBAs—seem hell-bent on carrying out now. So, it's still, first and foremost, an art form and that will never change. - Ken Fabert(112)


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Life in Vancouver
Surviving the First Week
18.11.2012 - 22.11.2012
Well this officially marks my first week in Canada.
It is a little unbelievable, as it feels as though it has been weeks already that I have been here. I have to keep reminding myself that I only touched down on the 17th November.
Since my last letter I have been busy again… always busy and it never seems to end. I do like it that way though.
On Monday 19th November I moved out of the backpackers I was staying at in GasTown (Area) of Downtown called C&N Backpackers to the Westside of Downtown into a much nicer backpackers on Granville Street called Samsun Backpackers. This company has a few hostels in different areas of Canada and is known as the best with it's own bar, restaurant, much better facilities, free WIFI and located on the cities nightlife strip with loads of restaurants, bars and Yes, night clubs which do seem to continue early into the morning. They have good budget meals too. I met some nice people while staying here. It does cost a few more dollars than the previous one but was well worth the spend.
However, not something that you can stick with for too long.
I did a fair bit of site-seeing of the Downtown Vancouver area; walking most of the main streets to familiarise myself, walks down to the Canada Pacific Centre located on the waterfront side. This is where all the large cruise liners pull into during the summer. From here you have a marvellous view over the water with West and North Vancouver on the other side, the snow capped mountains in the distance and you are right near the seaport where the sea planes fly in and land and take off out of the bay. Great to sit and watch.
I also visited some of the shopping centres to see what that was like.
All in all the city is very manageable on foot and is not as busy as a New York so you are not constantly playing dodge with the on-coming foot traffic.
I headed to the exchange office to apply for my SIN# (Social Insurance Number) and to meet the local co-ordinators who look after international guests. They gave me some information on banks and I also scouted their notice boards for potential employment.
I managed to secure a meeting with a bank rep for the next day and within 40 minutes had a bank account setup and my new ATM card in hand. Ever so friendly and efficient, unlike our terrible banks. I am with Scotia Bank of Canada and they have a 1 year free student/checking account which is great, so I don't pay any fees on my transactions and that will save some $$.
The weather has been pretty much the same as before – it is usually grey skies and on and off rain and/or drizzle with a winter chill in the air sweeping in from the water. I still battle with the fact that it literally only gets light around 7am. Anything before that and it is pitch black you would swear it was middle of the night. The sun then starts setting from around 4pm and usually by 5pm it is lights out. You end up wanting to be in bed by 7pm as it feels like midnight. We did have 2 fantastic days though. By that I mean it was still chilly, a little breezy but no rain which makes a huge difference to ones day. Not having to walk around with damp shoes and pants is a bonus.
There are so many Australians here. That nation is like a plague sweeping across the world. They are simply unavoidable and have totally overtaken the Germans when it comes to travel. I don't mind as I always find them good fun. I think the Australians themselves get fed up heading across the world to interact with other people, just to land up with their fellow ozzies again. I met 2 very nice Australians and we hung out now and again. Brett from Melbourne and Flo from Adelaide. Both also on a working holiday visa.
On Wednesday we decided to head out on a day trip together to go and see Grouse Mountain. There are 2 close mountains to Vancouver Downtown – Grouse and Cyprus Mountain both about 40 minutes away by public transport. We headed down to the waterfront caught a seaboat (ferry) across the waters to North Vancouver and from here a bus to the Base of Grouse Mountain. We all stood out like the 3 stooges after goofing up on our transport – which ticket to buy, which bus to get on and where to go, so I think our orientation is much better now. The bus driver on our last bus was a great sport and joked with us the whole way about our indecision on what we were doing. The bus drivers here are even nice and I am not sure what they put in their coffee in the morning but they are certainly lively and full of beans; singing, talking with the customers and announcing the next stop's and destinations in bizarre and funny accents. We were in hysterics the entire ride thinking they had all gone bloody mad.
After arriving at Grouse Mountain we saw the weather was not great in terms of visibility. The whole reason you go there is to go up the cable cart to see the views of the whole of Vancouver which was now not possible. We headed to information to see what else we could do while there. The reception must have thought we were crazy because everything we asked them was answered with "no that's closed due to weather" and so the ozzie girl and I laughed ourselves silly and the poor assistant at the desk couldn't understand what was so amusing at 9am in the morning. So we can't do hikes because of the visibility, we can't see anything from the top because of visibility, we can't do any of the other activities because of the rain. So what can we do? Watch Grizzly's and drink coffee at the starbucks at the top for $50. So sarcastically we were like "well how do you even know the grizzly's aren't sleeping too", what do you have a bear cam in their cages", to which the assistant said "Yes". They actually had a den camera to check when they are up and about, so felt a little stupid. Anyway we decided to leave and head to the next attraction not to far away and were very glad we did. I will go back when it is a better day.
We arrived at the Capilano Suspension Bridge Park. A beautiful park set amongst a bright green fur forest. The entrance and all throughout the park was covered with Christmas decorations and a myriad of coloured Christmas tree lights. It looked like a real winter wonderland. The bridge was just amazing to see. The length of 2 giant aircraft side by side swaying across the gorge. On the other side there are a tree-line canopy walks one can do, which was beautiful. The Douglas Fur trees in the park are just enormous and tower into the sky with thick trunks. Then there is the skywalk which is a semi circle walkway which juts out at the end of a cliff looking deep into the valley beneath you. It was definitely a trip worth doing and it only cost $29.
On the work front I have been sending out emails everyday and have know idea how many emails and enquiries I must have made. It is quite difficult to land ski resort jobs at this time as most of the hiring is done around September and October, which I obviously could not be here for, so the only hope you have right now is to try and find the last minute placements or wait until January which I am told might be a good option because generally there are a number of staff at the resorts who need replacing either because of quitting, being fired, finding out it really wasn't the thing for them or being injured on the mountains. Many young people show up wanting to do the ski season and by Xmas realise that it is actually hard work and not just a holiday to go messing around and drinking. So hopefully as bad as it sounds I can take someone's place.
On the TV front I have emailed some contacts again and scouted the web for openings. The tricky problem is that Canada and the USA are unionised which means some companies will only take you if you belong to a union and certain higher positions in the TV world are also unionised. You cannot just join a union as you have to be a permanent resident, so it really is a little tricky. But for the time being I am happy to not fall into the same trap and find myself working 24/7 in TV production work while here.
I have also been doing walk in's to different shops and companies, restaurants etc etc. I eventually heard back from one company that I had emailed and they asked me to complete further documents to be considered, which I did and sent them off, not really knowing what it was about.
The co-ordinator then got back to me and said they would have me on if I was interested. This company does not offer paid work immediately and does more of a volunteer work for board and lodging and then if they are happy with you, would look towards a more full time staff position. They have a working ranch and hunting lodge and offer backpackers and 1 year travel work visa holders the chance to work on a farm/ranch in the back country.
So, I mailed back and said I would give it some thought. It is not entirely what I want right now but at the same time it is a great way to save some money in the beginning rather than sitting in Vancouver without any work just spending money on accommodation and basic living expenses. I wanted to do something like that while in Australia and did not get the chance. It is a great way to really get a sense of life in the wilderness and to see the best that it has to offer rather than seeing something like that on a tourist bus which you would never truly get the real essence of.
All in all, I find Vancouver a beautiful city, very accessible and not as overcrowded as cities like NYC or London. Great people, Great food and an easy going lifestyle it seems.
Next Stop – The remote Chilcotin Mountains.
Posted by TezaTravels 16:00 Archived in Canada