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These authors contributed equally to this work.
This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
The Protein Data Bank (PDB) contains over 71,000 structures. Extensively studied proteins have hundreds of submissions available, including mutations, different complexes, and space groups, allowing for application of data-mining algorithms to analyze an array of static structures and gain insight about a protein's structural variation and possibly its dynamics. This investigation is a case study of HIV protease (PR) using in-house algorithms for data mining and structure superposition through generalized formulæ that account for multiple conformations and fractional occupancies. Temperature factors (
Established in 1971, the Protein Data Bank (PDB) has proved invaluable not only to the research community but also to students and educators [
Over 71,000 structures were in the database at the time of this writing, and more are deposited weekly [
The protein chosen as a case study to demonstrate this approach is the protease of the human immunodeficiency virus (HIV), the causative agent of acquired imunodeficiency syndrome (AIDS). The role of HIV protease (PR) in the maturation of the virus to an infective state has made it an attractive drug target. Several PR inhibitors have been used in AIDS therapy [
PR is a homodimer, as shown in
The PR dimer. Cartoon diagram of PDB ID 3hvp showing the monomers in orange and blue. Regions of PR structure are labeled, and relevant residue numbers are given in parenthesis. Rendered using PyMOL.
Variability of PR primary structures in the PDB. Graph considers the 811 PR monomers obtained as described in the experimental section, except PDB ID 2rkg, which contains an insertion. Non-standard residues (e.g., norleucine) are also included.
Since the first complete crystal structure of HIV-1 protease was solved [
Presented here is an investigation using a set of in-house tools to data-mine the PDB, superpose structures, and calculate various parameters by residue or by structure. Mean temperature factors (
The occupancy-weighted average α-carbon
Quality of deposited PR structures. Monomers that passed the
The PR monomers composing the study-set were superposed by the least squares method. Shown in
PR monomers. (
A possible explanation would be the existence of two distinct conformations of the enzyme: open and closed. In the latter, the presence of a ligand would enable interactions that hold the flap closed, ensuring its stability. In the former, steric clashes with symmetry-related molecules may limit flap opening and movement, or alternate conformers may be induced by amino acid variation. An analysis of crystal contacts across the various space groups mentioned in
Distribution of crystal contacts by residue in representative structures from each of the space groups reported for PR. This is not a table but a figure. Author need to use Word Table tools to format table.
PR B-factor and spatial displacement distribution. This table shows the mean spatial displacement observed in the ligand-bound Vs ligand-free PR structures. This table is a figure.
From this analysis of an entire array of structures, it is also possible to obtain an estimate of what Å value represents a significant conformational change. Referring to the statistics in
Representative table of the pairwise RMSD distance (Å) matrix of the 587 monomers in the study set. Rows and columns are labeled with the PDB ID and chain identifier. This is a figure.
To further understand the effects of ligand binding on PR structure, monomers were superposed within the bound and ligand-free subsets.
Ligand effects on PR monomer structure. (A) Superposition of ligand-free monomers; (B) superposition of mean ligand-free (orange) and bound (blue) monomers; (C) plot of spatial difference Vs residue number for mean ligand-free and bound monomers. Ribbon diagrams rendered using PyMOL.
Monomers were also organized on the basis of crystallographic space group and superposed to obtain mean monomers. Most of the representative monomers were in the closed conformation, as shown in
Superposition of mean PR monomer structures for the space groups: P21 (orange), C2 (red), P21212 (chartreuse), P212121 (yellow), I222 (purple), P41 (cyan), P43 (lime green), P41212 (blue), P43212 (magenta), I4122 (salmon), P61 (olive), P65 (brown), P6122 (pink) and I213 (green). Ribbon diagram rendered using PyMOL.
Distribution of PR structures by space group. In the strictest sense, the distribution should be further subdivided because not all structures belonging to the same space group have isomorphous unit cells.
A list of relevant PDB IDs was obtained by querying the PDB for structures matching the keywords "HIV protease." The same 174 hits were returned regardless of whether the query was executed programmatically or through the PDB's web interface. Expanding the search parameters to include "human immunodeficiency virus protease" increased the number of results to 405. However, a review of the literature revealed that the true number of relevant structures in the PDB is greater still. Using the aforementioned search parameters, a home-grown script that does not limit itself to phrases explicitly declared as keywords found an additional 34 PDB IDs. Several of the previously-missed files were in fact PR structures that had managed to evade normal search mechanisms by having only general keywords, such as hydrolase.
Of the 439 PDB IDs obtained, many corresponded not to PR, but to other proteins, including but not limited to integrase, reverse transcriptase, and proteases of the simian immunodeficiency viruses and feline immunodeficiency viruses (SIV and FIV, respectively). Therefore, a screening tool was implemented to omit structures containing no chains with primary structures within a specified edit distance [
The 368 structure files remaining after the previous step included several structures from NMR experiments and were split into 811 PR monomers. In the case of the covalently bonded PR dimers, this involved stripping any connecting residues. NMR structures were excluded from the study-set. The final data-set can be found in the supplementary data section.
The problem of superposing two sets of three-dimensional coordinates (atomic or not) reduces to identifying the rotation and translation that minimize some error function, usually the root-mean-square deviation (
Several methods are known for computing the optimal rotation. The most popular seems to be that of Kabsch [
Applying this algorithm to the atomic coordinates of protein structures involves accounting for fractional occupancies and multiple conformations. This amounts to using the occupancy-weighted centroids for the translation step and generalizing
and similarly for
In the simple case of a single conformation with full occupancy, the formula reduces to that of Horn [
Unfortunately, a closed-form recipe for the superposition of multiple structures does not exist. A first approach might be to superpose all structures onto the same reference structure, but the results may be erroneous if the reference is poorly chosen. A possible improvement would be to superpose each structure onto the mean of those already considered, but even this strategy is vulnerable to the effects of an arbitrary order of superposition because structures considered earlier are inherently attributed more importance. To alleviate this problem, the 587 monomers to be analyzed were sorted from highest to lowest resolution, with ties being broken in favor of the structure with the lowest mean Cα
Analysis of a static array of PDB structures to gain further insight about a protein has great potential as a method to deduce a statistical bar for structural variation, as demonstrated by this PR case study. While there are other algorithms to data-mine the PDB, it is clear from this study that quality control is required before using a data-set for analysis. There also exist algorithms to superpose structures, but to our knowledge, this is the first method that also occupancy-weighs available conformations for the superposition. The algorithms described here were used to data-mine the PDB, filter search results, perform quality control, and superpose structures. This made possible a comparison of
However, such an approach to protein study is made more difficult by the many different practices of PDB depositors even within the limits of a file format with a detailed specification. Choice of title, choice of keywords, numbering of residues, and organization into models and chains are often overlooked. This is unnoticeable to a human user, but it makes selection of the study-set the most complex and error-prone step of a data-mining endeavor. Additionally, many structures abuse
This project could not have happened without the work of all those who have deposited structures to the PDB and those who continue to maintain a smoothly-running database.
The authors declare no conflict of interest.


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By Susie Timm, Head Cheese
It's no secret that I love FnB in Old Town Scottsdale. I would argue it's the very best restaurant in Phoenix and ranks very high on a National level.
I know others agree with my assessment. I've spent a fair amount of time drinking local Rose at the counter and watching Chef Charleen Badman cook up a storm.
I showed up last week a bit before service to see if I could pick her brain.
Here's what she had to say about meat, her new fall menu and upcoming late night dishes:
Girl: What's your favorite fall vegetable to cook with?
Badman: Rutabaga–the heirloom varietals. Bob McClendon is growing me a special crop of them!
Girl: How did you get the inspiration for the pumpkin, pear, arugula and fried chicken livers dish that's on the menu?
Badman: We did it at my restaurant in NYC a few years back. I liked the sweetness of the pumpkin, the crunchiness of the pear and the fatty fried chicken liver love. We're careful not to overcook the liver–we want to keep it nice and moist.
Girl: What type of meat is most fun for you to cook and what's your fave way to cook it?
Badman: I love to make brisket, and braising by far is my favorite way.
Girl: What pig parts do you find most delish?
Badman: Bone in pork-shoulder. I love how juicy it is. The less expensive parts of meat have become so popular they are getting more expensive!
Girl: Any insider secrets about what dishes we'll see on your Saturday "Late Night" menu this fall/winter?
Badman: Hearty bowls, experimental noodle dishes, stinky fried fish on a Saturday night. Ceviche, posole. Hot, spicy, braisy soup. I'll cook stuff that sticks to your ribs.
Congrats Char on your recent nod in December's Food and Wine Magazine-on newsstands now!

subset: commoncrawl


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Day Care Rates
About Our Staff
Director's Message
Contact Us
Parkersburg Day Nursery, established in 1908, is the oldest childcare center in West Virginia. As a non-profit organization, we have been operating on the following mission for a century. "We will strive to promote a child's physical, mental, emotional and social growth within a caring environment". The Nursery is dedicated to caring for children whose parents or guardians are in need of quality childcare. The Nursery is operated on a non-discriminatory basis and the practice of this policy is proved through equal treatment regarding race, color, religion, sex, disability and national origin. PDN is dedicated to educating your child to become more independent and prepare them for their academic and social life in the years to come. The teachers on our staff are educated in early childhood development, and with their guidance, your child (ren) will grow socially, physically, mentally, and emotionally in a loving and caring environment.


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An Arkia Israel Airlines passenger plane made an emergency landing at Ben Gurion Airport on Sunday after a warning light indicated there was a fire in one of its two engines.
The ATR-type aircraft, carrying 67 passengers and crew, was heading from Eilat to Sde Dov airfield near Tel Aviv when a light came on in the cockpit alerting the two pilots to a problem with one of the plane's propeller engines.
The crew alerted passengers to the situation and asked them to assume emergency positions as the plane diverted to Israel's largest international airport, where rescue response teams were on hand to receive them.
The plane landed safely with no injuries reported.


text: Home > Books > Redemption The Wrong Choices eBook: $0.00 Author: Jonathan Austen Genres: Short Story, Single Author, Suspense Tags: Boston, Family, Fiction, Gangs, Jonathan Austen, Redemption, Short Story Would you kill an innocent person if it meant saving your life? Find out what Jackson does in this gut-wrenching, short story inspired by actual events. More info →


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Winter is in full swing here in Bloomington and as much as I love the snow, sometimes my wardrobe can feel a little boring. I mean I can only wear the same pant, sweater and boot combo so many times before I never want to wear them again. So what's the solution? It's actually quite simple: pair items you wouldn't usually consider wearing together for a refreshed look.
Before you begin to protest that you can't wear black and brown together or that wearing multiple patterns is too much, take a breath and check out the Fashionisto's outfit I spotted just outside the library. At first glance this outfit looks pretty standard, but after close inspection you can see how his style savvy skills came into play. This Fashionisto keeps his outfit pretty casual by pairing Gap straight-leg corduroys with an Urban Outfitters striped sweater. When you take a closer look, you'll notice how he carefully chose a black button-down with checkered lining to pull out the dark stitching in the sweater. He pulls his outfit together by rocking some vintage black kicks. His light brown cords balance the dark tones of his other pieces.
Now here at Indiana, school spirit is everywhere. However, sometimes spirit wear can be a bit pricy. You may be surprised to learn that other retailers besides your school's bookstore and other local shops sell clothes for your school. This Fashionisto snagged his gray IU puffer jacket from T.J.Maxx. By capping off his look with an IU snapback, this Fashionisto shows us he can rep his school spirit without relying on the usual T-shirt or sweatshirt.
Hint: If you are wary of mixing patterns, try color blocking. Choose a colored pant, a subdued hue like burgundy works and a burnt orange sweater with brown loafers. The colors won't be overwhelming, but your look will definitely be more interesting.


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Our promise to you is to never compromise quality, business ethics, reputation, or service.
At Sustainable Lumber we combine local wood, artisan quality, & Montana integrity. Our company is like family; we look after each other, we work hard & play hard. We're not in business to get rich, we're in business to make an honest living and be good stewards of our natural resources.
Thank you for trusting us on your next project, you won't be disappointed.
About Us »
© Sustainable Lumber Company
Contact Us | Phone: 406.642.7120


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Today, I was screamed at and told that I was denying someone's "second amendment" by not letting him through with a gun. I work at the border; he was trying to enter Canada. This is not the first time, and it probably won't be the last. FML
By Anonymous / Friday 12 April 2013 10:23 / Canada


text: On Mon, 2008-08-04 at 14:35 -0700, Garrick Staples wrote: > Your question was about running 'qstat' on two different pbs_servers was > returning the same results. I suggest that you are actually talking to the > same pbs_server both times. Looking at the server logs for job status > requests, you can discover if you are actually talking to two different servers > or not. Sorry about the confusion, I know what you're saying now. Interestingly, I'm tailing both server_log files for today and issuing 'qstat' and 'qstat @bcf:36001' and am not seeing any entries for job status requests in the log files. I can't do anything until Wednesday when the current jobs finish anyway, but thanks for the help Garrick. I'll get back to you then. -- Jeremy Mann jeremy at biochem.uthscsa.edu University of Texas Health Science Center Bioinformatics Core Facility http://www.bioinformatics.uthscsa.edu Phone: 210-567-2672


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2011-06-16 / Police
A burglar stole a $430 tennis bracelet from a home in the 5500 block of Foothill Drive June 6.
A thief stole a purse containing a $100 wallet with credit cards and $350 digital camera from a car parked in the 32000 block of Agoura Road next to Bogies restaurant June 6. There was $500 in damage to the vehicle. Another vehicle burglary occurred in the same area June 4 when someone stole a $350 purse containing $2,500 in cash and dental retainers valued at $400.
A person stole an $800 laptop computer from a truck parked in the 28900 block of Oak Creek Lanes June 2.
Someone snatched a $ 600 iPad and $400 skateboard from an apartment in the 29100 block of Oak Creek Lane May 28.
An arsonist started a small brush fire behind the post office in the 5100 block of Clareton Drive May 26.
A person caused $ 400 in damage to a car parked on Las Virgenes Road June 4.
A burglar stole a $ 1,000 purse containing a $500 pair of sunglasses, bank cards, makeup and other items valued at about $1,000 from a car parked near Malibu Creek State Park June 4.
During a traffic stop in the 4500 block of Las Virgenes Road June 4, authorities arrested two people in possession of burglary tools.
Burglars stole 10 riding saddles worth $40,000 and 14 saddles valued at $35,000 from Far West Farms in the 5100 block of Old Scandia Lane June 2.
A culprit stole $140 worth of items from a car parked near Gelson's market in the 22200 block of Mulholland Highway June 2. The thief caused $160 in damage while breaking into the vehicle.
A burglar stole a $5,000 watch and an $ 800 iPad from a car parked next to the Calabasas Country Club in the 4500 block of Park Entrada June 1.
Someone stole a $ 400 cellphone from a patron at the community center in the 27000 block of Malibu Hills Road May 31.
A thief took a $1,000 brass water regulator from a horse farm in the 5100 block of Scandia Lane June 5. A similar regulator was stolen from a property in the 22200 block of Mulholland Highway May 28.
Hidden Hills
A thief stole $30,000 worth of sports memorabilia, $8,000 worth of jewelry, $400 in cash and other items valued at about $ 5,000 from a home in the 5500 block of Bonneville Road June 1.
Oak Park
Property worth $500 was stolen from a vehicle at Oak Canyon Community Park at Kanan Road and Hollytree Drive May 29.
Property worth $750 was taken from a vehicle near Doubletree and Oak Springs drives May 29.
An unlocked residence in the 1200 block of Hidden Springs Avenue was burglarized between May 29 and 30.
Property was taken from an unlocked vehicle in the 1400 block of Forest Knoll Drive between May 29 and 31.
More than $3,000 in property was stolen from an unlocked vehicle in the 1200 block of Dubonnet Court between June 1 and 2.
Two men, 21 and 24, were arrested for being under the influence of a controlled substance and possession of drug paraphernalia in the 5700 block of Oak Bend Lane June 7.
Westlake Village
A vandal shattered a $ 220 window on a vehicle parked in the 31000 block of Old Colony Way June 2.


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G5 yo-yo by YoYoFactory
We love micro yo-yos! This one is fully functional and competition-quality, but just barely over 1.5" in diameter. Perfect pocket yo-yo for advance players! And no "pocket yo-yo" is NOT a euphemism.
I've had this iPod since it came out, and it still works great (knocking on wood). True it's a little bigger than the new ones, but if you're looking for an entry level mp3 player, this one will do the job
This George Foreman grill comes equipped with 5 interchangeable plates and has a power and ready light as well as an on and off button. It has a grill, a steak and two waffle plates and also comes with a shallow pan.Tags: G5, George Foreman grill, indoor grills and sandwich makers, Grill with 5 plates, Interchangeable Plates, power and ready lightAdded 9 Years Ago from Walmart
Man this is awesome its fast>>>>Tags: computers, electronics, Apple, internet, PC, G5, productivity, powermac, designAdded 10 Years Ago from Apple
Hey, I just want to win the MacAirTags: fashion, graphic, art, computers, electronics, technology, beauty, Apple, computingAdded 10 Years Ago from Amazon.com


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Subject: Re: [htdig] How-to Suppress HtSearch PageList Output in htdig-3.2.0b2.
From: Gilles Detillieux (firstname.lastname@example.com)
Date: Fri May 19 2000 - 14:10:49 PDT
According to Jeff Hill:
> HtSearch in htdig-3.2.0b2 appears to put a pagelist at the end of its
> output differently than htdig-3.1.5
> I'm using php as a wrapper, and can't seem to surppress the page list.
> This wouldn't be so bad, except that the page list is incorrect (due to
> the PHP wrapper).
As far as I can tell, both versions generate the pagelist in pretty much
the same way, using the same config attributes and template variables.
What technique did you use with 3.1.5 to supress the page list that
does not seem to work with 3.2.0b2? You may want to compare how you
set up your templates and config file in both versions, as there may be
a configuration problem with your 3.2.0b2 setup.
-- Gilles R. Detillieux E-mail: <firstname.lastname@example.com> Spinal Cord Research Centre WWW: http://www.scrc.umanitoba.ca/~grdetil Dept. Physiology, U. of Manitoba Phone: (204)789-3766 Winnipeg, MB R3E 3J7 (Canada) Fax: (204)789-3930
------------------------------------ To unsubscribe from the htdig mailing list, send a message to email@example.com You will receive a message to confirm this.
This archive was generated by hypermail 2b28 : Fri May 19 2000 - 11:59:08 PDT


text:
Adeline was born the middle child of a large family in Dublin. She worked in the recruitment industry for years and when she quit started to write fulltime. Adeline also studied literature in UCD and literature and history in DCU.
Her favourite pastime is reading murder mysteries and watching them on TV with her husband.
She still lives in Dublin with her husband and extended family.
Latest Novel


text:
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Discussions started by Sharon7257
ultrasound after lipo
My doctor is recommending I get ultrasound to prevent lumps after lipo, which I had 11 days ago. What any one have any information about this? READ MORE
Recent comments from Sharon7257
Thanks, weather is nice and warm. Healing slowly. Only drawback, Mexican doctor didn't prescribe narcotics so I had to bring some from home. Finally getting around more but boy, it's a slow process. Maybe it's my age? Have to go... READ COMMENT
Hi; I'm 56 years old and have had this "pooch" for 30 years since my daughter's birth. I only weigh 110 lb so I was very frustrated. Found a wonderful doctor in Mexico and had lipo everywhere (legs, hips, knees, waist) and a tummy... READ COMMENT


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The carefully engineered nutrients in our Longevity System Rx and Skin System Rx provide the additional power you will greatly benefit from as a result of the cellular regeneration and protein synthesis that occurs when either AEON or SOMASTATIN are taken. If you prefer to take either AEON or SOMASTATIN without supplementation, you will certainly still receive noticeable benefits, although we believe it best that you also utilize our Longevity System Rx. (Please note, however, when AEON and SOMASTATIN are taken together, we highly recommend the supporting use of our Longevity System Rx). Read More
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77N-0080 Polychlorinated Biphenyls (PCB'S)
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text:
Infrastructure & Services Section :: Page 11
Village objects to court ruling in tap-in case
On Friday, April 20, the Village of Yellow Springs filed objections to the first ruling by a Greene County magistrate who decided in favor of Ken and Betheen Struewing in their case against the Village.
Small towns, bigger water bills
The price we pay for the water that flows from our taps is determined by a variety of factors, including a bit of guesswork
AMP offers green pricing program
At Village Council's April 16 meeting, Eric Lloyd of AMP, the Village's municipal power cooperative, presented information on a new green pricing program, Ecosmart Choice, that AMP is offering to its members.
Council eyes wind power
At their April 16 meeting, Village Council members heard a presentation from Eric Lloyd of AMP, the municipal electric cooperative, regarding the Blue Creek Wind Energy Project, a new wind farm in northwest Ohio.
Court favors Struewings
Last week a Greene County Common Pleas Court magistrate ruled in favor of Ken and Betheen Struewing in their case against the Village over property rights.
Wastewater upgrades showcased
More than 100 area wastewater and water treatment plant operators from Southwest Ohio visited the Village water facilities on Thursday.
Conley's hard work his passion
By the time he came to work as a Village crewman 19 years ago, Dave Conley was already a veteran of infrastructure maintenance.
Solar farm is still on track
As long as the sun continues to shine on Yellow Springs, the Village could begin receiving power from a local solar photovoltaic project in 2012.
Upgrade makes sewage plant shiny and new
After nearly two years of work and about $3 million in upgrades, the Village's refurbished wastewater treatment plant now has not only higher water quality but also a new name.
Village Reclamation Plant gets a shine
Villagers are invited to take a tour of the newly upgraded Water Reclamation Plant (formerly wastewater treatment plant) this Thursday, Dec. 29, 11–3 p.m.


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Kathmandu, Nepal - Hustle and Bustle and Glorious Sights!
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November 27th 2009
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Thamel Street Scene, central Kathmandu
It's always slightly unnerving arriving in a foreign country under the cloak of darkness. You don't know what to expect, you don't know where your hotel is, and as you wait for your ride, it's not such a leap to conjure bad things happening down some dimly-lit alleyway.
Our place of stay, the famous Kathmandu Guest House, had emailed that we'd be picked up at the airport. What wasn't mentioned was that the vehicle was a decrepit van driven by a madman who seemed to take joy in ignoring basic lane discipline. Just outside the airport, he brought his van to a sudden halt, allowing another man to join him in the front. He wasn't introduced and we soon set off again. Angela and I looked at each other, but what could we do? I peered outside trying to make anything out but could see nothing, apart from other vehicles, all of which were beeping and flashing their lights. Perhaps we would be driven somewhere and robbed? We swerved to avoid a woman walking with a sack on her head and she soon disappeared into the gloom. Occasionally we would catch a glimpse of a homeless person searching through a
A boy on stilts collects a few rupees
pile of rubbish with their hands.
Ten minutes later we arrived at a more densely populated part of the city which was thankfully well lit due to the sheer amount of bars, restaurants and shops lining the streets. It was here we caught sight of our fist hippie. He was a dreadlocked man in his forties wandering around in his own personal nirvana. Our taxi came to a sharp standstill, caught up in a snarl of traffic that immediately became an orchestra of beeping and hand gesturing. The taxi driver's friend seized this as a chance to jump out, waving goodbye as he did so. A few minutes later we arrived at our hotel.
The room we'd booked at the Kathmandu Guest House was billed as a deluxe room, the second most expensive at $70 per night. "This is the most basic room I've stayed in for years," was Angela's first comment as she regarded the tiny space that made up our living quarters. "And it smells of mothballs. Are you sure this is a deluxe room? God only knows what the other rooms are like."
The other rooms we didn't see but we did look at
A man on his cycle waits for custom
a tariff explaining them. Under the deluxe room was the garden view room, which charged $55 a night. The list then went though standard, economy, basic and simplicity before it reached the bottom of the barrel, a room billed as ultra basic. It cost £2 a night. "God help anyone who stays in one of those rooms," I quipped as we unpacked a few things. There was mold on the ceiling and mildew in the bathroom. It was only the next day we found out that our room hadn't been a deluxe room, it had been a standard, costing only $30 per night.
"You want hashish?" said the small man who approached us from out of nowhere. We were wandering along the nighttime streets of Thamel, the area of Kathmandu where our hotel was located. We ignored the dealer and browsed the shops. Most were catering for tourists, selling pirate DVDs, second-hand books, hippie clothing and trekking trips. The streets were busy, filled with a mixture of Westerners and locals, the latter mainly made up of taxi and cyclo drivers touting for business. In some rooftop bars, rock bands plied their trade, some of them sounding astonishingly good.
Nepalese rupees
Another man approached, this time simply begging, but he was soon replaced by a younger moustached man. After a quick scan around he whispered something out of the corner of his mouth. "You want marijuana? Golden?" Brushing him away, we found that most of the shops were beginning to close, lowering their shutters and so we retreated back to the hotel.
The next day we saw a totally different side to Kathmandu. Bathed in sunshine, the city was warm and welcoming. Along every side street was a photogenic picture: there a man leaning against a brightly coloured cyclo, here a small boy wandering on lofty stilts with a tin in his hand. Further on, a toothless old woman sitting on the floor peddling a selection of vegetables. Coils of wires hung above street level and as we stood looking at them, a man approached. "You want shoe shine?" he said. He was armed with a briefcase filled with what I presumed was shoe shining equipment. We said no and walked on, coming to a selection of shops specializing in fabric. One shop proudly displayed a sign reading: 100% Pashmina! Nepal Quality! Seeing our interest a man quickly appeared. "Come
The many street signs of Thamel
in please. I give you first customer discount!"
"Look at this shop!" I said to Angela as we passed by an establishment known as the Family Dental Clinic. In the window was a collection of false teeth and a large bowl filled with molars. "I reckon the only qualification you need here is a pair of pliers and a hammer." I said. It wasn't the only such place either - there were half a dozen of them along the same section of street.
We arrived at Durbar Square, a large complex of Hindu and Buddhist temples. Once we'd paid the admission fee, we were greeted with the sight of some impressive looking temples, reminding me of the Kathmandu I'd seen on travel documentaries. As well as the temples, they were some sacred cows milling about, but they weren't the only things milling. The holy men were out and about too, willing to pose for a photograph in return for a few rupees. There were also plenty of guides in attendance and although we initially brushed them off we soon changed our mind.
Within seconds we had procured the service of not one guide but two. "We have
A women sells her vegetables
been guides for fifteen years," one of the men told us. "We met at university while studying to be guides. Sometimes we work alone but often we work together."
Our first port of call was the Jagannath Temple, the oldest one in the square, noted for the pornographic carvings on its roof struts. Without the guides we would have easily missed them. Male statues with members almost as long as their legs were on display, as were smiling gods inserting their members into women's orifices with wanton abandon. And even the animals were at it. One carving depicted a horse mounted atop another beast!
"This next place we will visit is the House of the Living Goddess, home of the Kumari," said one of our guides as he led us inside a small courtyard. Along the way we were pestered by the peddlers. They were selling wooden flutes, bracelets and other trinkets, but their persistence paid off because Angela ended up buying a few items.
I'd already read about the Kumari. She was a young Nepalese girl aged between four and thirteen who was a living embodiment of an actual Goddess. The girl was chosen carefully based
Holy Men of Durbar Square
upon a set of strict physical features, such as the colour of her eyes and shape of her teeth. When enough prospective candidates had been found, they had to go through stage two of the selection process. The girls were gathered in a darkened room and had to endure a night of torment. Men dressed as demons would cavort in front of the girls, shouting and screaming, trying to make the girls flinch. All around the room were hideous masks, and in the midst of this madness, a buffalo would be slaughtered. This would be a good night out for one of the old hippies in Kathmandu, but for a four-year-old girl, it must have been terrifying. A true goddess, though, in the face of such horror, would not have flinched. The young girl in question would then get to live in luxury until puberty set in when she would be reverted back into a mortal and the search for a new Kumari would begin.
At the end of our tour we stopped for a drink with our two guides at a roof top cafe in the heart of Durbar Square. I bought them both an Everest Beer. "I
Durbar Square - the ancient home of royalty
have noticed something about your haggling," said one of the men, taking a slurp of his drink. "If they say it costs 2000 rupees, you should say 500 and then work your way up, not go half and then work your way up. You are being too generous! For instance, those slippers you bought for 1000 rupees (£8), I could have got for 150 rupees."
The view from the terrace was quite amazing, affording a view of the whole of Durbar Square as well as the mountains. I asked the men about the commonly occurring strike days, when public transport ground to a halt, and sometimes even shops, schools and offices were closed. "Ah yes, the strikes!" said one of the men smiling. "These are like carnival day in Kathmandu! People do not go to work and instead they have a party. We like strike days, don't we?" he asked his pal, who nodded enthusiastically.
"At this time of year, we start work at 10am and finish at 4pm," replied one of the men after I'd inquired about their working day. "One some days we might get three jobs, but on others no jobs at all. It depends."
Banana seller waits for custom
After we'd finished our drinks, it was time to bid them farewell. They wished us a good day.
Just along from Durbar Square was Freak Street which became famous in the late 1960s as a gathering place for hippies as they made their way across Nepal. Hashish shops and cheap hotels plied their business along the street to cater for them, and possibly because of this, the road became known as Freak Street. Today, the hippies were long gone, banished to wandering around Thamel, and we didn't linger long either, heading off towards a white tower we'd seen from the roof top cafe.
Bhimsen Tower was built in 1825 and resembled a giant white lighthouse. After paying to enter, Angela and I found ourselves climbing the spiraling staircase than ran up in the inside of the tower. At the half way stage, after climbing about a hundred steps, I was well and truly knackered, but once at the top the views were amazing, spanning the whole of Kathmandu.
Two days later, after returning from our trip to Pokhara, we were back at the Kathmandu Guest House. This time we opted for the garden view room, which offered
The faded past of Freak Street
a panoramic vista of some dingy backstreet of Kathmandu. There was not an inch of vegetation in sight, let alone a garden. Feeling slightly disappointed we caught a taxi to the Monkey Temple, or as it was properly known, Swayambhunath.
"I can drop you off here and you can climb the steps to the very top," said the taxi driver as we reached a high point on the hill where the array of Buddhist and Hindu shrines were located. "Or I can take you to the top and you can walk back down?" We opted for option two and after being deposited we were soon through the gates, finding out why it was nicknamed the monkey temple.
They were everywhere - hundreds of them - and not in least bit shy. Baby ones clung to their mother's backs as they clambered along walls or pathways, and every now and again, a whole troop of them would cross our path. In the epicentre of the complex were a selection of stupas, temples and shops peddling the unusual tourist fare, but the monkeys were far more interesting. Some of the more acrobatic ones were even sliding down the handrails that
Flags overlooking Kathmandu
lined the steps. Buddhist prayer wheels were in abundance, and a few saffron-robed monks gave the place an almost authentic feel. The views were amazing - eagles soaring above the vast expanse of the city. "I didn't realise Kathmandu was so huge," said Angela.
Back in central Kathmandu, we paid the taxi driver and headed off to buy some teeth. Angela was adamant about purchasing some so that she could show the children in her class how fizzy drinks affected the enamel coating. We headed towards the row of 'dentists' we'd seen a few days previously. Wandering the streets of Thamel seemed a world away from the tranquility of Pokhora. The streets were grimy and often smelly and it was so damned noisy! Even the cyclos trundling along made a God-awful racket, with their horns sounding like a cross between a trumpet and a dog's squeezy toy. Some of the drivers even utilised empty plastic bottles as their horn, which were surprisingly loud.
At the first tooth shop, Angela tried her luck but it was to no avail. She came out shaking her head. "The woman said the teeth were not for sale." I told Angela that I
Wooden pornography
would try in the next shop.
I wandered in, marvelling at the array of false teeth and went straight up to the proprietor. "Hello," I said smiling, showing him my teeth and wondering at the same time whether he was studying them in the hope of harvesting them later. "I am a teacher and I need some teeth to show my class an experiment on tooth decay. I only need two though! Not a full set! Can I please buy some?" The man looked at me incredulously before shaking his head. But I persisted and he eventually cracked, producing two teeth from his till! I bid him good day and handed Angela my booty.
With the light fading fast, I was suddenly accosted by another shoe shiner. He'd evidently spotted the poor state of my shoes and saw an opportunity to make a few rupees. As he followed us, Angela suggested that I take him up. "They are a state," she pointed out. "And while you get them done I can do some shopping."
The shoe shiner and I agreed on a price of fifty rupees and he sat me down and began to work. While the
Nepal Ice - one of the 3 local beers
rest of Kathmandu passed us by, the man removed my shoes and began to shine. "Where are you from?" he asked me. When I told him he smiled and said that England was a good country. "I am married with two children," he said. "My third child died because we are so poor." I commiserated with him, but couldn't shake off the notion that the man's sob story was just another way of extracting more cash from me. He inspected the inside of my shoe and found that there was some repair work to be done there. He removed a small jar from his case and began sticking small pieces of leather to the inside casing. "This glue," he told me, "is the same kind that street children sniff at night. It helps them go to sleep."
The man finished one shoe and began on the other. Opposite me, a traffic jam had formed and I found myself to be the centre of attention. I tried to ignore them and moved my feet closer to the pavement to avoid the wheels of passing vehicles. The shoe shiner declared that the insole of the other shoe unrepairable and jumped up,
Newspapers of Nepal
disappearing from sight. A few minutes later he returned with a new insole and set to work again. The fifty rupees we'd initially agreed upon seemed woefully inadequate now that he had been working for over twenty minutes.
As the glue began to harden, the shoe shiner spoke once again. "My mother and father died from drinking whiskey. They drank it all day and they left me with nothing. I work all day and all I want is to send my children to school. But school is very expensive for a poor person like me. But at least I have a job. I have been a shoe shiner for ten years!"
I decided, that when the man had finished, I would give him double the original asking price. After all, 100 rupees was nothing (80p) and he had worked for nearly forty minutes so far. In fact my shoes had never looked better. As he passed me the finished articles, he told me that he wanted 500 rupees. I was taken aback and told him so. "But I have worked hard and I have even bought new insoles. Please, I beg you! Think of my family!"
Angela poses near the Bhimsen Tower
told him that I would pay 300 rupees and nothing more and the man nodded in resignation. I removed my wallet and found to my dismay that I had nothing less than a 500 rupee note. I asked the shoe shiner if he had any change but he shook his head. Feeling like a cad, I told him I needed some change and he finally nodded and rooted around in all of his pockets, eventually coming up with 120 rupees which he gave me in return for my 500. All the notes were crumpled and I hypothesized that it was the total amount of money he'd made all day. I thanked him and told him he'd done an excellent job to which I received a toothy grin.
Ten minutes later I was sat at the Kathmandu Guest House bar and ordered a beer. Angela was still shopping somewhere and when the beer arrived I paid for it there and then. 310 rupees for a bottle of Everest. I sat back and took a slurp, enjoying the refreshing beer until I realised that I had paid the shoe shiner only ten rupees more for all the effort and diligence he
I think I'll have my teeth done here, love
had taken. I felt like an even bigger cad.
The next, morning was another bright and sunny day in Nepal. It seemed the guide books had indeed been correct about the weather when they advised that the best time to visit was between October and December. For our final full day in Nepal, we caught a taxi to Patan.
Once a city in its own right, Patan was now more like a suburb of Kathmandu, and like Kathmandu, it had its own Durbar Square, which if anything, was even better than Kathmandu's. We had a wander around before heading south along a busy road filled with shops selling amongst other things, metal jugs and pots, for which Patan was famous.
"These poor dogs," said Angela as we spotted yet another one curled up on the pavement. Further on we came across a dead one, left to rot with flies. As we stopped to consult the map we spied another street dog. This particular one looked alert enough but malnourished. When I bought a bottle of water from a nearby store, it looked up at me hopefully. Angela poured some water into a dry puddle but the dog
Durbar Square, Patan
ignored it. I bought some cake from the same store and threw it at the dog. It devoured it in a second and followed us for while before sloping off.
We decided to visit Nepal's one and only zoo, located in Patan, and after paying the entrance fee we wandered around the enclosures avoiding the hordes of people that were strolling everywhere. A few school parties were about too, and because it was lunch time, the children were all sat in rows eating their packed lunches. Oddly, we seemed to be the only Westerners in attendance.
As zoos go, and neither Angela nor I would ever consider ourselves to be connoisseurs, the one at Patan wasn't too bad. We saw hippos, vultures, turtles, monkeys and jackals but we didn't see the star attraction, the Bengal tiger. It was housed in a large enclosure but had hidden itself somewhere. It didn't stop people trying to spot it though. A crowd was jostling for position along the high section of wall overlooking the tiger's enclosure. As I tried to squeeze in to get a better view but was elbowed out of the way by an elderly Indian lady who literally
Happy hippo in Patan Zoo
shoved me sideways. Afterwards, as we wandered away, I told Angela about the rude woman and she shook her head. "I should've shoved her over the edge," I said, "And then we would've seen the bloody tiger."
Instead of catching taxi back to Thamal, we elected to walk. Along the way we walked across a bridge spanning the Bagmati River. Along one of its edges a shanty town had developed, and from our vantage point we could see a family sat around a fire. They were dressed in rags but they looked happy as hell, all smiling as they talked amongst themselves. We looked away from them and into the river which was piled with rubbish, including the carcass of some unidentifiable animal. "This smell is horrible," said Angela. "It's like a toilet. I can't believe this water starts in the Himalayas."
As we got closer to the heart of Kathmandu, the traffic began to thicken and so did the fumes. A long row of motorbikes were queued up along the side of the road, most with their engines switched off. Further down the road we saw what they were waiting for - petrol. I'd already read in
Kathmandu Guest House
the Himalayan Times that there was a shortage of fuel in Kathmandu because of strikes and that tempers were starting to fray. "Did you see that man?" I said to Angela. She nodded looking disgusted. As the man in question passed us he was still buckling up his belt, walking away from the pile of shit he'd just left. "I couldn't live in Kathmandu," I said.
We approached Durbar Square just as a demonstration was beginning. Hundreds of policemen were lining the street, most carrying riot shields and hefty-looking sticks. In the distance we could hear a man's voice over a loudspeaker. As we neared the heart of the square, the amount of police thickened. They had roadblocked all entry points to the square and were stood in groups along the edges. Some nearby shops were pulling down their shutters and quite close to where we where stood was the demonstration itself. I informed Angela that the British Foreign Office had advised all UK citizens avoid any sort of demonstration or public gathering.
"Hello! You need guide?" We turned around to see the two men who'd shown us around a few days previously. We all shook hands and
Man with his pots, Patan
they told us that the demonstration was by farmers. I gestured to the police and joked whether they were expecting any violence. "Oh yes!" answered one of the men. "There will be lots of violence, but do not worry; It is safe for a while. I don't suppose you want a guide again? Today we have had no customers." We said goodbye to the men and made our way back to the hotel. The next day would be time to go home.
-Lots to see
-Good food
-Very friendly people
-Very safe and tourist friendly
-Dusty and dirty
-Heavy fumes from the traffic
-Traffic jams and endless beeping
-Men (but sometimes women) gargling their throats before hawking it out onto the pavement
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Jason Smart
My aim was to visit at least 100 countries, and with Brazil, I finally did it. I'm now loitering at 104. Or is it 105, I lose count... Unlike a lot of fellow travellers, I tend to only dip my feet into a country, quite often only staying a day or two before heading off somewhere else. Country numbers 54 and 55 were my first trips alone - something I never thought I'd do. In 2013 I published an e-book entitled The Red Quest, detailing my mission to visit each and every country of the former Soviet Union. Along the way I sa...
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Brief history of Nepal
In 1951, the Nepalese monarch ended the century-old system of rule by hereditary premiers and instituted a cabinet system of government. Reforms in 1990 established a multiparty democracy within the framework of a constitutional monarchy. A Maoist in...
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Bagmati River
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A man manages to fall asleep amid the madness of downtown Kathmandu
Temple in the heart of Thamel
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19th December 2011
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About copy right
By the way, did you apply for any permission before you take photographs of that country. Of course, all the physical existance there in that country is the prime property of that nation before you claim any so called copy right.
19th December 2011
Jason Smart
Can you elaborate on what you mean? For instance, if I take a photo of an aeroplane flying over my house, should I write to the airline in question to see if it's okay? Or do you mean photos of people? If that's what you're referring to, then rest assured that permission was always asked for, and subsequently granted. Happy travelling!
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pirate flag hoodie
My (almost) 5-year-old wants this hoodie in a big way. I gotta admit it's pretty cool. Made of navy cotton with a fleecey inside for softness, there's a ragged pirate flag across the back, and a skull applique on the front. There are roomy pockets on the zip-front, which is always a plus (at least to MY boy who regularly stuffs his pockets full.)


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"All Keane was looking to do was to maybe draw a penalty, and try to hit it into his hand. He's a clever player and he did well." -- Seattle coach Sigi Schmid on the handball call on Seattle's Adam Johansson off a cross from the Los Angeles Galaxy's Robbie Keane that led to a penalty-kick goal, ruining the Sounders' comeback attempt in the Western Conference final series. (Seattle Times) "It wasn't calculated. You can't try to get a penalty in that situation. I was just trying to get the ball across and the referee gave a penalty." -- Robbie ...More


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Contemporary Neutrals
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Unsurprisingly, the Contemporary Neutrals have an urban, contemporary feel and to most will appear grey. However, the magic of these neutrals lies in the fact that they have an underlying lilac tone, which brings a little edge to decorative schemes while retaining a certain warmth
Accent with the darker Charleston Gray and Dove Tale for a layered scheme with lots of depth.
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Poland Flag and Description
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The Poland flag was officially adopted on August 1, 1919.
Red and white have long been associated with Poland and its coat of arms. On the modern flag, white is said to represent the hope for peace by all of Poland's people, while red still recalls the symbolic reference to socialism from days gone by.
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Men attacked on Cleveland's west side
(Cleveland) – Police are looking for suspects in an overnight homicide. Two men were rushed to MetroHealth Medical Center by private auto after being wounded on the near west side
Officers from the second district received a radio assignment to respond to MetroHealth for 2 male victims of gunshots.
Upon arrival officers learned that one of the males had suffered a gunshot wound to upper body. He later died at MetroHealth.
The second victim was treated for a gunshot wound to the arm area.
Detectives say the shootings occurred in the area of W. 38th and Newark.
Victims were inside a vehicle when another vehicle described as a champagne or grey Ford Taurus pulled up, with an unknown occupant firing multiple shots.
Get breaking news sent to your mobile phone. Text "news" to 21095.
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(Photo by Ken Robinson/WTAM)


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Latest question:
How do you think the new GigE standards will influence the machine vision industry?
Respond or ask your question now!
As a fabless semiconductor company, Pixelplus is focused on creatingproprietary design technologies to develop CMOS image sensors with sharp, colorful and enhanced image quality, size efficiency, and low power consumption.
Forward Looking Statement
This press release contains certain statements, including statements regarding the performance, achievements and capabilities of and demand for Pixelplus' PO2010, PO3030, and PO3130 CMOS image sensors, that are nothistorical in nature but are "forward-looking statements" within the meaning of the "safe-harbor" provisions of the Private Securities Litigation Reform Act of 1995. Forward-looking statements generally can be identified by the useof forward-looking terminology, such as "may," "will," "expect," "intend,""estimate," "anticipate," "believe," "project," or "continue" or the negativeof such words or other similar words. Pixelplus cautions readers thatforward-looking statements are based on the Company's current expectations,estimates, and assumptions about our company and our industry, and are subjectto a number of risks and uncertainties. These risks and uncertainties, whichcould cause the forward-looking statements and Pixelplus' results to differmaterially, include, without limitation: potential errors, design flaws orany other problems with the PO2010, PO3030, and PO3130 CMOS image sensors; risks associated with building customer acceptance of and demand for thePO2010, PO3030, and PO3130 CMOS image sensors; the development of the marketfor CMOS image sensors in the camera phone market, as well as in markets forother mobile applications incorporating image sensors; the rapid changes intechnical requirements for camera phone products; competitive risks; as wellas any other risks detailed from time to time in Pixelplus' filings and reports to the U. S. Securities and Exchange Commission. Pixelplus expressly disclaims any obligation to update information contained in any forward-looking statement whether as a result of new information, future events orotherwise.Contact: Stephen Cho Pixelplus Co., Ltd. 5th Floor, Intellige I, KINS Tower 25-1 Jeongja-dong, Bundang-gu, Seongnam-si Gyeonggi-do 463-811, Republic of Korea +82-31-600-5310 OR Taylor Rafferty: London -- Laura Martin at +44 (0)20 7614 2900 New York -- Allon Bloch at +1 212 889 4350 Seoul -- Min Kim at +82 (0)2 2000 5753 Tokyo -- Yuhau Lin at +81 (0)3 5444 2730 Email firstname.lastname@example.com
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Stone Barrington is back in an edge-of-your-seat adventure in the New York Times bestselling series.
After giving legal advice to his latest client, Stone Barrington thinks he's done with the man. But it's soon clear that Stone hasn't seen the end of the case. Several people are keenly interested in this gentleman's activities and how they may relate to a long-ago crime…and some of them will stop at nothing to find the information they desire.
On a hunt that… (more)
Publisher: G.P. Putnam's Sons (January 07, 2014)
Format: EPUB
Page count: 320 pages
File size: 1.3 MB
Protection: DRM
Language: English


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The proposed project, scheduled to begin next year, will include 500 high-end units across four towers. More
Land use governs our present and future opportunities. More
The college in Lakeland, Fla., finally realizes Frank Lloyd Wright's 1939 'Usonian... Moreweaetxdyvaydzcwq
Gentle winds provide passive cooling at a Florida waterfront home. More
For Disney World, Michael Graves designed a pair of hotels with playful cartoon imagery. More
Minneapolis, St. Augustine, Orlando, Washington, D.C. More
Last week on vacation in Florida, my family and I visited the Green Cay Wetlands, a constructed wetland and nature preserve that also serves as the final-stage treatment facility for municipal wastewater. More
The "Florida Architecture: 100 Years. 100 Places." competition highlights the... More
Much has been made of the death of the McMansion, but new trends are questioning whether that pronouncement was made too early. More
The New American Home 2012 achieved the highest levels of green building certification possible, providing insight into the process and by-products of submitting to such standards. More


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We haven't talked a whole lot about the Barnes & Noble Nook since its launch last December, but given one bit of news that came out yesterday, it felt like the right time to see what's been going on with this dual-screened e-reader. The big news yesterday is that according to a Digitimes Research analyst, the Nook shipped more units than the Amazon Kindle in the month of March. This statement is based on figures from upstream suppliers, so there's definitely an element of speculation in the numbers, but Digitimes says the Nook accounted for 53% of the e-readers shipped to vendors during that month. Keep in mind that this is numbers shipped, not sell-through numbers, but it still seems like a positive sign for the Nook.
[ Get news and reviews on tech toys in ITworld's personal tech newsletter]
Backing up a bit, last week the Nook got a pretty significant software update. The update finally added the Read in Store feature that was mentioned earlier, meaning you can take your Nook to a Barnes & Noble store, connect to the in-store WiFi and read from a selection of e-books for free. In theory you can read the whole book, but access is limited to an hour per day. Sounds like a nice way to spend a lunch hour to me. If you're hooked by the end of your hour you can buy the e-book and keep reading; it's like picking up a print book only you're not leaving your greasy fingerprints on a copy of a book you ultimately decide not to buy! The update also added a couple of games (Sudoku and Chess) and improved performance. CNET has a nice run down of the new features based on a hands on demo during which they asked the Barnes & Noble representative if and when there'd be a B&N eReader App for the iPad. The news is good. Yes there will be one and it is expected some time in May. The app will be tailored to the iPad, with an iPhone/iPod Touch version following shortly afterwards. Lastly is the news that Best Buy has started selling the Nook, as of April 18th, for the standard Nook price of $259. (Could this be part of the reason for those big March numbers? Would Nooks destined for Best Buy stores have shipped as early as March?) Presumably being in Best Buy will expose a whole new segment of consumers to the Nook, and hopefully we'll see some discounts or sales once the device is in a "big box" store. Barnes & Noble faces a new challenge later this month when Amazon starts selling the Kindle in Target stores. For the first time, consumers will be able to walk into a store and handle a Kindle before deciding whether or not to buy one. This has been an advantage that Barnes & Noble held over Amazon up until now.


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Hope dims for 2 men missing in Suwannee River
Published: Wednesday, March 13, 2013 at 9:54 a.m.
Last Modified: Wednesday, March 13, 2013 at 2:30 p.m.
Al Melendez is well-familiar with the Suwannee River. As a guide for the Adventure Outpost in High Springs, he has paddled its twists and turns many times.
Now, Melendez, 38, and his intended son-in-law, Haemant Nathooram, 19, are missing on the Suwannee and are the subjects of an intensive search since they tried on Monday to help Melendez's son when he had a mishap on the river.
"He's always helping people. He helps animals. He always gives," Melendez's wife, Christina, said Wednesday afternoon. "People just love him. He's just that kind of person."
Gilchrist County Sheriff's Lt. Jeff Manning said Wednesday afternoon that the men had not been found despite an intensive search by several agencies.
Manning added that the likelihood of finding the men alive has diminished.
"There is always hope but due to the circumstances and the way the water is and the temperature, it's turned into more of a search at this point than a rescue," Manning said. "The level of the river is above normal and the current is fast."
The search has been under way since about 8 p.m. Monday when the Gilchrist County Sheriff's Office got a call about a possible drowning at the Log Landing Wildlife Management Area.
Christina Melendez said several family members went to the Log Landing area to play with a remote control boat — both Melendez's son Taylor, 8, and Nathooram are remote control enthusiasts.
"They went to play with the boat and get out of the house for a while. My son, when the boat got stuck, went to the edge to try to get it unstuck. He fell over," Christina Melendez said. "The closest person was Haemant. He can't swim but he was trying to grab (Taylor) and fell in. "My husband and everybody jumped in. They made a line of people helping. They said my husband started floating on his back. He got his shirt off. He was trying to save Haemant."
Taylor was safely brought to shore but Melendez and Nathooram did not make it back.
Manning said various agencies continued to search Wednesday morning, including divers from Columbia County Sheriff's Office, boat and search squad from the Dixie County Sheriff's Office and aircraft from the Florida Fish and Wildlife Conservation Commission.
Christina Melendez is a Gilchrist County native, while her husband moved to the region many years ago from New York City.
"He works at the Adventure Outpost. He did tours on the river," Christina said. "People are trying to get boats together to keep looking."
Nathooram's mother, Savidree, said he was born in Guyana and moved to New York with the family when he was 7. Several members of the family, including Savidree and Nathooram's father, Ravil, are in Gilchrist County while the search is under way.
Savidree said Nathooram planned to attend college and enjoyed working out, riding bikes and playing with remote control airplanes and boats.
"He's lovely, caring. A good person. He always looked after me. I love him with my heart and soul," Savidree said Wednesday. "He came to Florida and said, mom, I want to move there. I said, OK baby, go. I was so happy for my son because he said everybody loves him."
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SPAIN- In Zaragoza, a large city between Madrid and Barcelona ringed by wind turbines, is a Natural Spaces Dome model #114 low profile, 12.2 meter (40') diameter dome home. It was constructed in 2000 with the assistance of a Natural Spaces building crew, the owners, and several local people including a local soccer team. They loved climbing around on the dome.
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Definition of nephridia
plural of nephridium 1
The word "nephridia" uses 9 letters: A D E H I I N P R.
No direct anagrams for nephridia found in this word list.
Words formed by adding one letter before or after nephridia (in bold), or to adehiinpr in any order:
l - nephridial
List all words starting with nephridia, words containing nephridia or words ending with nephridia
All words formed from nephridia by changing one letter
Other words with the same letter pairs: ne ep ph hr ri id di ia
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Monet lilies to star in 'most valuable' art auction
A rare water-lily painting by Claude Monet will star among dozens of modern masterpieces this month in what is being billed as the most valuable art auction ever held in London, Christie's said Thursday
Painted in 1906, the work is part of the French Impressionist's iconic Nympheas series and was included in his historic exhibition in Paris three years later, the auction house said.
Christie's said it expected the London sale of 63 modern and impressionist artworks, on June 23, to realise between 163.67 and 231.18 million pounds (196/276 million euros, 240/338 million dollars).
Offered from a private collection, the Monet alone is expected to fetch between 30 and 40 million pounds, it said in a statement.
The London sale follows a similar auction at Christie's New York on May 4, where Pablo Picasso's "Nude, Green Leaves and Bust" set a new record as the most expensive work of art ever sold, fetching 106.4 million dollars.
Another star work is the Blue Period masterpiece by Picasso, "Portrait of Angel Fernandez de Soto", a painting of his friend and fellow artist also known as "The Absinthe Drinker," expected to fetch 30 to 40 million pounds.
One of the last great portraits painted by the turn-of-the-century Austrian symbolist Gustav Klimt, his "Portrait of Ria Munk III" is also expected to go for between 14 million and 18 million pounds, Christie's said.
Other high-profile lots include "Parc de l'hopital Saint-Paul," painted in 1889 by Vincent van Gogh during his voluntary confinement at an asylum in Provence, as well as works by Henri Matisse, Rene Magritte and Otto Dix.


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|Boyd Bruce McGlothlin Sr (George Washington McGlothlin6, Thomas McGlothlin5, Daniel Jonathan McLaughlin Sr4, Davis Larkin McLaughlin3, Jacob McLaughlin2, J. McLaughlin1) was born 12 NOV 1906 in Roane County, West Virginia, and died 18 MAY 1947 in St Francis Hospital, Charleston, West Virginia. He was buried 20 MAY 1947 in Epling Chapel Cemetery, Looneyville, Roane Co., WV. He married Ella Catherine Boothe 1925. She was born 07 JUL 1906 in West Virginia, and died 14 DEC 1985. She was buried 17 DEC 1985 in Epling Chapel Cemetery, Looneyville, WV.
Child of Boyd Bruce McGlothlin Sr and Ella Catherine Boothe is:
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On 9/12/05, Joao Alexandre <jalexandre1964 at yahoo dot com> wrote:
> I've also more or less the same doubts, as I have a
> place where I would like to portect a LAN and WAN (not
> Internet, just a Cisco router connecting to other
> offices) from a Wireless AP that will have a wireless
> camera (from LAN users connect and see whats
> happening) and some wireless notebooks (that sould
> access the LAN and WAN but in a protected way).
Disable NAT entirely (enable advanced outbound NAT without any NAT
rules to accomplish this), and put the WAN interface on your LAN.
As for anything more specific, depends on what you want to plug into
where, how everything is laid out, etc.


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Ever since presidential press conferences were put on a regular basis by Woodrow Wilson, reporters have been hampered by some form of restriction preventing them from quoting the President directly. There was good reason for the precaution. It helped protect the President from slips of the tongue that might later embarrass him or the U.S. During the Roosevelt Administration, a standard rule was put into effect that was followed for more than 20 years: newsmen may paraphrase what the President says, but may not quote him directly. Last week the rule was changed. Press Secretary James C. Hagerty announced that...
The Press: Direct from the President
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CRITICS of plans to 'privatise' a Lancashire university – which has a campus in Burnley – will meet tonight to discuss their next move.
Vice-chancellor Malcolm McVicar has unveiled plans to convert the University of Central Lancashire from a corporation, limited by statute, to a private company, where he would be 'chief executive'.
Unions fear it will obscure scrutiny of their decision-making process – and offer a pathway into higher education for private equity firms.
Michael MacNeil, higher education head of the University and College Union (UCU), will address a meeting at Greenbank lecture theatre, in Preston, as will Unison regional secretary Kevan Nelson, and TUC regional head Lynn Collins.
Mr MacNeil said: "Our universities' reputations for excellence are built on the fact that education, not profit, comes first."
The University and College Union has also launched an online protest petition.


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Turks face integration challenges in Germany
BERLIN -- In the vestibule of Germany's largest mosque, identity is complicated.
Zehra Yilmaz says her German passport will get her into a voting booth on election day, but her Turkish name and Muslim head scarf kept her out of apartments she tried to rent. She has lived in Germany since she was 2, but her home has been in Turkish enclaves segregated from the rest of Germany by language, culture and a mutual belief that one day the foreigners would go home.
"I'm not really Turkish, and I'm not really German," says Zehra Yilmaz, 46.
Inside the European Union's most populous country, a parallel society has grown. Muslim immigrants, mostly Turkish, flooded into Germany beginning in the 1960s, recruited by companies to augment the post-war work force. Yilmaz's father planned to stay five years, enough time to save enough for a car and washing machine. The government granted them entry as guest workers.
"The first generation came at a time when the economy was booming, and they expected to make money and go back. That hasn't happened," said Jochen Hippler, a political science and Middle Eastern studies professor at Duisburg-Essen University.
Clustered in neighborhood enclaves, such as Marxloh in Duisburg and Kreuzberg in Berlin, the children and grandchildren of that first immigrant wave grew up in Germany without ever attaining citizenship. Until 2000, German law defined citizenship by ethnicity, rather than a person's place of birth.
Integration efforts began in earnest only recently, after the third generation of immigrants was born. Hampering those efforts is a distrust of Muslims heightened by the 9/11 attacks, an ethnic German population that abides foreigners warily, and an unwillingness among many in Turkish communities to break with their families and give up Turkish citizenship to become legally German.
Kreuzberg's central market is emblematic. On Fridays, the Muslim holy day, the market bustles with Turkish-speaking shoppers. Small Turkish flags flutter from an apartment window above Kaiser Market, a grocery store. Deli signs are written in Turkish.
"You think, 'Am I in Istanbul?' " said Marcus Ferman, 35, of Berlin. It's not German, he said, and it worries him. "When you come to a country, you should not keep all of where you came from. ... There are (children) going to school who cannot speak a word of German. This is very troubling."
The communities are insulated, with unemployment rates twice the national average and lower levels of education. They are home to people who feel unwanted by the country in which they live. It's the sort of thing that makes counter-terrorism experts nervous. Though none of those who planned the 9/11 attacks were Turkish, the core group -- the Hamburg Cell -- plotted from an apartment in Germany.
"We must consider extremists from visa-waiver countries, who are merely an e-ticket away from the United States," FBI Director Robert Mueller told the Council on Foreign Relations in February.
Much of Europe struggles with its growing Muslim population. The reactions have been sporadic. Switzerland amended its constitution in November to ban construction of minarets. Riots in French Muslim communities erupted in 2005. British academics warn some universities and neighborhoods have become breeding grounds for extremism.
Turkey's candidacy to join the European Union encountered staunch opposition, including from German Chancellor Angela Merkel. Some see it as a challenge to the traditional notion of Europe, just as the Kreuzberg market seems un-German to Ferman.
Defining what constitutes German, however, gets tricky, Hippler said.
"A German banker in Frankfurt, neo-Nazi skinheads in East Germany, punk bands in Berlin, liberal academics in German big cities, ... Pope Benedict, and so on. They are all German. What exactly is it they have in common culturally• And the truth is, I couldn't tell you, besides the language," Hippler said.
Germany has been spared the clashes that happen elsewhere in Europe. Local disputes over the building of mosques in places such as Cologne and East Berlin have not coalesced into an organized national opposition to Islam. German culture accounts for some of this, Ferman said.
"Germans are not the type to take to the streets," he said. "But it is in their hearts."
The state of North Rhine-Westphalia, which encompasses Duisburg and Merkez Mosque, has handled integration better than most places in Germany. Its history helped. Here, in the former center of Germany's steel and coal industries, immigrants seeking work came from Poland and Italy, as well as Turkey.
The state's officials were among the first to allow public schools to teach courses on Islam alongside those on Christianity and Judaism. Preschoolers can take free German language classes. A neo-Nazi protest of Merkez's October 2008 opening was greeted by a far larger counter-protest led by the Catholic and Protestant churches.
About 70 percent of the country's 4 million Muslims came from Turkey, a secular country.
"You have people here who are Muslims, but who are Muslims (in a similar way) to being Protestant or Catholic here," Hippler said. "They are technically members of a religion, but they are not very interested in practicing that."
Religious debates distract people from the harder, costlier changes the country needs to make, he said.
"Jobs and housing and education and language (classes) cost money. Talking about religion is cost-free," Hippler said. "Framing migration policy in terms of religion is not a smart thing to do in a secular country. If you want to talk about migration, talk about migration. Don't talk about God."
Children born in Germany since 2000 have an automatic right to citizenship, but they must decide between ages 18 and 23. If they choose to be German, they must give up citizenship in their parents' country.
Ken Eis, 23, is caught in the middle. Born in Nigeria to a German mother and Nigerian father, his mother's citizenship gives him the option to be German. But the Kreuzberg resident, who has lived in Germany since he was 14, doesn't plan to stay much longer.
"This is one of the few nations that still holds on to its nationalism," said Eis, who is unemployed. He plans to return to Nigeria to try to find a job. "I don't see a future for me in Germany."
Yilmaz knows the feeling.
"When I was 14, I was crying in my pillow at night, 'Why am I not German?' The Germans didn't accept me as a whole German girl. I didn't wear a head scarf at this time. I wore normal German clothes. But I have a foreign name. I am a foreigner for them," she said. In her frustration, she vowed to return to her family's roots.
Then she visited Ankara, her family's ancestral city, and saw how different gender norms affected the country's women.
"They are not like me," Yilmaz said. "In Turkey, I have no rights as a woman. I can't be active as a woman. ... My home is in Germany. It is in Duisburg."


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Optimus Prime 2 Titanium Series Die CastPrice: $49.99 Write a review | No reviews for this product.
In addition to being an ideal leader, he is a war machine of incredible power. Nearly unbeatable in single combat, his enemies have resorted to an endless string of dirty tricks to lay him low, only to see him rebound every time, stronger than ever before. His strength and confidence, however, hide a deeply reflective spirit. During solitary moments, he has been known to doubt his skill as a leader, for his deep compassion has - at time - clouded his judgement. Thankfully, his brilliant mind and the dedication of his compatriots have always manged to snatch victory from the evil claws of the Predacons.
Features hidden arm blasters and converts from robot to fire truck. Combines with his brother Ultra Magnus to form Omega Prime.
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Mental Health
Have Mental Health Questions? Ask a Psychiatrist Online
"Everybody is a genius. But if you judge a fish by its ability to climb a tree, it will spend its whole life believing it is stupid." – Einstein
How do you feel she is manipulating you? If you feel used and do not feel like it is meeting your needs, it sounds like you already know what is best for you.
We've dated since mid January has an insatiable appetite for fine things including travel, clothing, exotic resorts etc
but whener we meet her friends i'm always introduced as Blake
not her friend Blake, or her boyfriend, but Blake
her birthday last weekend she first wanted an expensive camera which i bought then she decided she needed a new Pilates chair, which i bought and then she really needed some resort time at a spa
So... how do you feel she is manipulating you? If it is not working for you... why do you stay?
and then this week she asked if i could fly her to NJ so she could visit her family
Do you have problems saying no? Consistently put the needs of others ahead of your own?
when i tell her that its not working for me and i'm not feeling the love back, she dismisses me and tells me that she is too busy to txt and say hello
but she can text the rest of the world and tell them about what she is doing every 10 minutes of her life
i for sure have problems saying no and putting her feelings ahead of mine
i don't want to hurt her
you may benefit from reading the following books:
The Wizard of Oz and other Narcissists and
but she consisttenly makes me feel like an errand boy
Disarming the Narcissists...
hmmm...just googled it...i'll order it
they describe a common pattern in relationships where one partner's behaviors (entitled/demanding) are extremely difficult for the other partner to set boundaries around due to their own struggles with codependency...
they are both very helpful resources and can help you break this pattern in this and future relationships
I personally prefer the "Disarming the Narcissist" by Wendy Behary... but they both are good
i suspect that i have mental issues where i know it's happening and i know its borderline abusive on her part, but i can't stop
i pray every night that she will find someone else and leave me alone
it will hurt me for a spell, but i'll recover and the suffering will end
then those books are definitely custom made for you... they will help you stop participating in your own boundary violations
thanks Doc...i've ordered the wizard fo Oz and other Narcisissits from Amazon
awesome... good luck!
if someone claims to really really really love me....do i have to love them back?
nope... you don't have to love anyone except yourself
thanks Doc...the book will be here in two days...
thank you for being on the other end of the keyboard...i feel a tad better already
no problem... you're very welcome....
Hello, the book has arrived at the hotel that I'm staying at in Phoenix…I should have it in my hands this evening….thanks for following up


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These ladies riding gloves are made from stylish leather and suede snakeskin and feature re-enforced panels for added protection between the thumb and ring fingers. An adjustable tab with fashionable embossed logo help keep the gloves in place whilst riding.
How to measure for gloves
Measure around the hand at the fullest part (exclude thumb)
B) Measure from the tip of the middle finger to the base of the hand
C) Use the LARGEST of these two measurements for the correct size glove
D) If you are RIGHT handed, take measurements from your RIGHT hand
F) If you are LEFT handed, take measurements from your LEFT hand
G) The number of inches measured equals the size of the glove
(example: A 7" measurement equals a size 7 glove)
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· Next Working Day – £8.95. Order Monday-Friday by 5pm for delivery the next day* (Monday to Saturday)
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text: Location: City of Tortage (White Sands) Retrieved from "http://aoc.wikia.com/wiki/Barachan_Panther?oldid=49551" Ad blocker interference detected! Wikia is a free-to-use site that makes money from advertising. We have a modified experience for viewers using ad blockers Wikia is not accessible if you've made further modifications. Remove the custom ad blocker rule(s) and the page will load as expected. Categories: Bestiary City of Tortage Mobs Add category Cancel Save


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Mark Millar Talks Kick-Ass 2 & More
On building a new Marvel universe at Fox
Mark Millar, comic-book creator and now Fox's top comic-book advisor, came in to the Empire Podcast recently and talked about Kick-Ass 2, his comics work and his new role overseeing the Marvel titles at 20th Century Fox. Here's a sampling of what he had to say, for those of you who don't do so much of the listening thing. First up: Kick-Ass 2. Will it be true to its wildly violent source material?
"It's insanely faithful; it's actually almost scene-for-scene. When you see it balanced as a screenplay, it has enough light and shade that the really awful stuff that happens, you can deal with because there's been enough laughs. It's like Tarantino: Tarantino's amazing because he can have you laughing one minute and then someone's head gets blown over the back of a car window."
"It's a little darker, I think, but we planned it that way. The idea was going to be it would be like Empire Strikes Back to Star Wars, so the world would get bigger and the world would get darker... Every scene that's in the book is there, but maybe toned down just a little because otherwise it would be too much. But it's harsh!"
Millar also talked about ending the series with book three, and how it compares to Star Wars, and talked about Matthew McConaughey being in the frame for Big Daddy in the first Kick-Ass. Then we also asked about his work at 20th Century Fox.
"You've got Kevin Feige and Joss Whedon doing such an amazing job over at Marvel Studios, but the cooler characters really are at Fox. Fox bought this because it was the best stuff, Sony came in and got Spider-Man - and what Marvel had left was the characters that people didn't think would translate onto film, and that's since been proved brilliantly wrong... So Fox are thinking, let's try to get something cohesive going."
"So they brought me in to oversee that, to work out a plan. At this stage, I can't get too specific, but I have a three-to-four year plan of where things could go... just figuring out how everything could work together and not contradict each other. But I don't want everybody showing up in everybody's film. My dream, as a fan, is when you go and see any Marvel movie it feels like they're all taking place in the one universe. Fox and Sony and Marvel should all be best friends and see it as a shared responsibility."
Millar also talked about why having Marvel's movies at three separate studios is a good thing, and made some very tantalising suggestions about the future of Marvel's cinematic universe, but for those we suggest you listen to the whole podcast, which you can get your hands if you click play on the SoundCloud file below (Mark's interview starts at 42.47), and remember, you can subscribe to the Empire Podcast via iTunes or our RSS feed.


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Philly Green Dress Run Pre-Lewd, Friday March 16th @Grumpy's
Philly Green Dress Run Pre-Lewd Run, Friday March 16th at Grumpy's Tavern Upstairs
Meet at 7:30pm, Pack Off at 8pm
Hash Cash: $10
Hare: Rear Engineer
Location: Grumpy's Tavern UPSTAIRS
1545 S. 9th St., Philadelphia (9th and Cross Street)
Specials: Most bottles – Yuengling, Coors Light, Bud, Miller, etc. $2
Cheap pitchers and tap beers downstairs, including Yards.
Full bar upstairs too.
Are you ready for the Green Dress Run? Do you need a little beer to get you in the right mood before donning your green dresses and wigs? Well come on out to the Philly Full Moon Green Dress Pre-Lewd R*n to get in the spirit. We've got an experienced hare known for his skill in finding urban shiggy and tremendous circle jerks. Run through the triangularly intersecting confusing streets of South Philly with a pack of your 20-40 best friends. Who knows where the trail will take us… hopefully to a beer or shot near…
You have to be a little lucky to find a spot right nearby so we encourage biking, carpooling, and public transit. Behold the handy dandy Google Map below.
View Grumpy's in a larger map


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For Most in U.S., a Day of Joy and Reverence; For Most in the Nation, Joy and Reverence
By LAWRENCE VAN GELDER ();
July 22, 1969,
, Section , Page 1, Column , words
Some Americans looked to God, others to their television screens, and there were those who tried to ignore it all.
July 22, 1969
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