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Genetic polymorphisms in oxidative stress pathway genes may contribute to carcinogenesis, disease recurrence, treatment response, and clinical outcomes. We applied a pathway-based approach to determine the effects of multiple single nucleotide polymorphisms (SNPs) within this pathway on clinical outcomes in non-muscle-invasive bladder cancer (NMIBC) patients treated with Bacillus Calmette-Guérin (BCG). We genotyped 276 SNPs in 38 genes and evaluated their associations with clinical outcomes in 421 NMIBC patients. Twenty-eight SNPs were associated with recurrence in the BCG-treated group (P<0.05). Six SNPs, including five in NEIL2 gene from the overall and BCG group remained significantly associated with recurrence after multiple comparison adjustments (q<0.1). Cumulative unfavorable genotype analysis showed that the risk of recurrence increased with increasing number of unfavorable genotypes. In the analysis of risk factors associated with progression to disease, rs3890995 in UNG, remained significant after adjustment for multiple comparison (q<0.1). These results support the hypothesis that genetic variations in host oxidative stress genes in NMIBC patients may affect response to therapy with BCG.
Citation: Wei H, Kamat A, Chen M, Ke H-L, Chang DW, Yin J, et al. (2012) Association of Polymorphisms in Oxidative Stress Genes with Clinical Outcomes for Bladder Cancer Treated with Bacillus Calmette-Guérin. PLoS ONE 7(6): e38533. https://doi.org/10.1371/journal.pone.0038533
Editor: Rajvir Dahiya, UCSF/VA Medical Center, United States of America
Received: December 8, 2011; Accepted: May 6, 2012; Published: June 12, 2012
Copyright: © 2012 Wei et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Funding: Supported by grants from National Institutes of Health/National Cancer Institute: U01 CA 127615, R01 CA 74880, P50 CA 91846, and R01 CA 131335 (http://www.cancer.gov/researchandfunding). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Competing interests: The authors have declared that no competing interests exist.
In the United States, bladder cancer is the fourth most common cancer and the eighth leading cause of death from cancer in men, with an estimated 69,250 new cases and 14,990 deaths in 2011 [1]. Most (75%–85%) bladder cancers are non–muscle invasive at first diagnosis, which include superficial non-invasive (pTa), minimally-invasive (pT1), or carcinoma in situ (CIS) [2]. Overall bladder cancer recurrence rates of non–muscle invasive bladder cancer (NMIBC) have been reported to be 31–78% at 5 years, and for high risk groups, 17–45% patients will progress to muscle invasive disease at 5 years [3]–[4]. Transurethral resection (TUR) is the gold standard for diagnosis and low risk Ta T1 transitional cell carcinoma (TCC) treatment [5]. However, recurrence at 3 months for patient with multifocal tumors varied between 7% and 46%, suggesting different TUR qualities [5].
Tumor cells often show an increased level of DNA oxidation products and oxidation-induced mutations [6]. Oxidative stress causes protein, lipid, and DNA damage and is a critical pathophysiological event implicated in several human pathologies, including cancer [7]–[8]. However, accelerated repair of oxidized DNA can protect cancer cells from harmful oxidative DNA damage [9] and is associated with metastasis and poor patient survival [10]. Many oxidative stress genes, such as eNOS, MnSOD, and GPX are polymorphic and have been studied for association with cancer risks and clinical outcomes [11]–[14].
To reduce the recurrence and progression of NMIBC, intravesical installation of Bacillus Calmette-Guérin (BCG) is often administered after TUR. BCG administration has been reported to induce local oxidative stress, which may mediate the antitumor activity [15]. We hypothesized that polymorphisms of oxidative stress–pathway genes may modulate the risk of recurrence and progression in BCG treated patients. To test this hypothesis, we conducted a study to evaluate the effects of 276 single-nucleotide polymorphisms (SNPs) in 38 key genes from the oxidative-stress pathway. To our knowledge, this is the first study to explore the association between a comprehensive panel of polymorphisms of the oxidative stress–pathway genes and risk of recurrence or progression in NMIBC patients, particularly in those receiving BCG therapy.
Materials and Methods
Ethics Statement
Written informed consents were obtained from all patients prior to enrollment in this study. The study was approved by the Institutional Review Boards at MD Anderson Cancer Center and Baylor College of Medicine.
Study Population
The study population and enrollment procedures were described previously [16]. Patients were recruited from The University of Texas MD Anderson Cancer Center and Baylor College of Medicine as a part of an ongoing project since 1999. All patients were identified by reviewing daily electronic clinic schedules at the Urology and GU Medical Oncology clinics. The NMIBC patients were newly diagnosed, histologically confirmed, and had not been previously treated with chemotherapy or radiotherapy at the time of recruitment. There were no restrictions for age, gender, ethnicity, histology or stage on recruitment. Since more than 90% of our recruited cases were transitional cell carcinoma (TCC), we only included TCC cases in this study. In addition, the majority of patients in our study population (90.6%) were Caucasians; therefore, we restricted the analysis to Caucasians to limit the confounding effect from population stratification. A total of 421 NMIBC patients were included in this study.
Epidemiological and Clinical Data Collection
M.D. Anderson staff interviewers administered a 45-minute in-person interview to all participants to collect data on demographic characteristics, tobacco use history, medical history, occupation and exposure, and family history of cancer. At the end of the interview, all participants donated a small blood sample for DNA extraction before receiving any treatment. Patients treated with TUR were followed up with periodic cystoscopic examinations, and subsequently some were treated with BCG. This treatment consisted of either BCG for 6 weekly instillations (induction BCG, iBCG) or iBCG + maintenance BCG (mBCG) in 3 weekly cycles given at 3, 6, 12, 18, 24, and 30 months after iBCG [17]. Clinical data were obtained from medical records by trained chart review specialists. The end points of outcome assessment in this study included recurrence and progression, which was calculated from the date of diagnosis to the date of endpoint events, death or last followup, whichever came first. Tumor recurrence was defined as a newly detected bladder tumor following a negative follow-up cystoscopy, and tumor progression was defined as the transition from non–muscle-invasive to invasive or metastatic disease. Patients who died or lost to follow up before the endpoint events were censored.
Selection and Genotyping of Polymorphisms in Oxidative Stress–Pathway Genes
We compiled gene list using SNPs3D bioinformatic tools (http://www.snps3d.org) [18]. We then identified tagging SNPs from the Hapmap database (http://www.hapmap.com). Similar to our previous study [19], all SNPs fit the following criteria: r2<0.8, minor allele frequency (MAF) >0.05, and located within 10 kb upstream of the 5′-untranslated region (UTR) and 10 kb downstream of the 3′-UTR of the gene. We also included potentially functional SNPs with MAFs >0.01 (e.g., coding SNPs and SNPs in UTRs, promoters, or splice sites).The genotyping was performed using Illumina's iSelect custom SNP array (Illumina, San Diego, CA) and the average call rate was 99.7%.
Luciferase Reporter Assay to Determine Effect of the NEIL2:rs4639 Alleles on Regulation of NEIL2 Expression by microRNAs
A reporter construct derived from pGL3 (Ambion) containing the 3′-UTR of NEIL2 was generated as follows: a 1.35-kb fragment of the NEIL2 3′-UTR was amplified from genomic DNA with the following primers: Forward1, 5′-GAAGATGGGTTACAGAGGCT; Reverse1, 5′-CAGACATCGTGGTGACAGAG. Subsequently, a 0.35-kb nested PCR fragment of 3′-UTR containing rs4639 was generated with primers: Forward2, 5′- AATTCTAGAGGGATACAGGCACCAAGAGGCGG; Reverse2, 5′- GTAGGCCGGCCGCGAGTAACAGTGAGCTTTAT. The amplified product was digested with XbaI and FseI and subcloned into pGL3 control vector. Variant NEIL2 allele construct was generated by site-directed mutagenesis with primers: Forward3, 5′- GATTTGTTGgACAATTCAGGAATCAAGG and Reverse3, 5′-TCCTGAATTGTcCAACAAATCAACAGTCAC.
UM-UC-9 bladder epithelial cancer cells were kindly provided by Dr. Barton Grossman's lab and were authenticated within six months prior to our study [20]. UM-UC-9 cells were transfected with 0.5 µg of the wild-type or variant NEIL2 3′-UTR construct along with 5 pmol of negative RNA control (scrambled sequence), miR-421, or miR-1200 microRNA (miRNA) mimic (Sigma-Aldrich, St. Louis, MO) and 10 ng of pGL4 Renilla luciferase reporter (Ambion, Carlsbad, CA) using Lipofectamine 2000 (Invitrogen, Carlsbad, CA) for 36 hours. The reporter expression was analyzed using the Dual-Luciferase Reporter Assay System (Promega, Madison, WI) and luciferase activities were measured in a FLUOstar Optima microplate reader (BMG Labtech, Cary, NC). Each assay was repeated independently three times with five replicates.
Statistical Analyses
Statistical analyses were performed using STATA 10.0 (Stata Corp., College Station, TX, USA). The χ2 test (for categorical variables) or Student's t-test (for continuous variables) was used to compare characteristics between the groups of patients with or without disease outcome. Linkage disequilibrium (LD) between individual SNPs was evaluated, with r2>0.8 were defined as being in the same haplotype block.
For each patient, we calculated the recurrence-free survival time as the time from diagnosis to recurrence, progression or to the date of death or last follow-up. Patients who were lost to follow-up or died before the end-point event were censored. We calculated person-years at risk within each genotype category as the sum of the recurrence-free survival times of all subjects in that genotype category. The effects of genotypes of SNPs on bladder cancer outcomes were estimated as hazard ratios and 95% confidence intervals (95% CI) using multivariate Cox regression under the dominant, recessive, and additive models of inheritance adjusted for age, gender, and smoking status, where appropriate. To control for multiple comparison, a q value (a false discovery rate [FDR]-adjusted P value) was used to adjust the significance level for individual SNPs. The q value was calculated by the q value package implemented in the R software. A bootstrap resampling method, using 100 bootstrap samples, was applied to internally validate the results. P for trend value was calculated with the number of unfavorable genotypes as continuous variable using unconditional Cox regression.
All analyses were stratified by age, gender, smoking status, tumor stage, tumor grade, and treatment. For the cumulative effects of multiple genetic variants, the adverse genotypes were summed and categorized by the number of adverse genotypes in subjects. To evaluate the cumulative effects of genetic variants, we summed up adverse genotypes (genotypes associated with significantly increased risk in the main effect analysis after adjustment for multiple comparisons) for each subject. Kaplan-Meier plots and log-rank tests were applied to compare the differences between the recurrence-free survival times of different genotypes. Non-parametric Wilcoxon Ranksum test was used to compare differences in luciferase activities in the reporter assay. All statistical tests were two-sided.
Characteristics of the Study Population
Of the 421 Caucasian patients we followed, 346 (82.2%) were men and 75 (17.8%) were women. Among them, 232 (55.1%) had disease recurrence, with a median recurrence-free survival time of 14.05 months. As shown in Table S1, no significant differences for recurrence rate were identified based on age (P = 0.68), sex (P = 0.11), smoking status (P = 0.69), cancer stage (P = 0.13), or cancer grade (P = 0.19). There were no significant differences in progression by age (P = 0.05) or smoking status (P = 0.96). Men had higher rates of disease progression than women (P = 0.01) and patients with a higher stage or grade were also more likely to experience progression (P<0.01). Since BCG was primarily administered to those with higher risk of recurrence [21], we compared different BCG treatments on risks of recurrence and progression. Compared to iBCG, mBCG treatment was significantly associated with reduced risks of recurrence and progression (P<0.01).
Analyses of Disease Recurrence Stratified by Treatment
Twenty five SNPs were significantly associated with recurrence risk in overall patients, and after adjusting for multiple comparisons, 6 remained significant, with a q-value ≤0.1 (Table S2). In the TUR patients, 34 SNPs were significantly associated with recurrence risk (P<0.05) but after adjusting for multiple comparisons none remained significant (Table S3). In the BCG-treated patients, 28 SNPs were significantly associated with recurrence, and after adjusting for multiple comparisons, 6 remained significant, with a q-value ≤0.1 (Table 1; Table S4).
To internally validate these results, we performed random bootstrap sampling of the significant SNPs for 100 iterations and listed the number of times that the P value was <0.05. In BCG-treated patients, four of the five top SNPs in NEIL2 had highly consistent results, with bootstrap P values <0.05 for greater than 90% of samplings (Table 1).
Cumulative Effects of Multiple SNPs on Recurrence in NMIBC Patients
We summed the number of unfavorable genotypes for each individual and categorized the patients by tertile distribution of their recurrence risk, which showed dose-dependent trend among three groups (P trend <0.0001). In total patients, compared with the low-risk group, the median-risk and high-risk groups had a 1.2-fold (HR, 1.21, 95% CI, 0.85–1.71) and a 2.2-fold (HR, 2.21, 95% CI, 1.60–3.05) higher risk of recurrence, respectively (P<0.01; Table 2). Among BCG (iBCG alone or iBCG plus mBCG) treated patients, compared with the low-risk group, the median-risk and high-risk groups had a 1.46-fold (HR, 1.46, 95% CI, 0.9–2.38) and a 3.5-fold (HR, 3.52, 95% CI, 2.23–5.55) higher recurrence risk, respectively (P<0.01; Table 2). Kaplan-Meier estimates of the total and BCG-treatment groups indicated differences in median recurrence-free survival times (MST) (log rank test, P = 0.0001; Figure 1 A and B).
(A) Kaplan-Meier estimates of recurrence-free survival in all NMIBC patients grouped by the three risk groups as categorized by the number of unfavorable genotypes in the oxidative stress pathway. Recurrence-free median survival time [MST] = 42.3, 12.5, and 5.6 months for low, medium, and high risk patients, respectively (P log-rank = 0.0001). (B) Kaplan-Meier estimates of recurrence-free survival in BCG-treated patients grouped by the three risk groups as categorized by the number of unfavorable genotypes in the oxidative stress pathway. MST = 66.1, 25.4, and 16.6 months) for low, medium, and high risk patients, respectively (P log-rank = 0.0001). (C) Overall Kaplan-Meier estimates of the effect of UNG:rs3890995 genotypes on progression-free survival in NMIBC patients (in the three risk subgroups, progression-free survival were greater than the follow-up time of 132.6 months). Compared with patients carrying homozygous variant genotype, those with at least one wildtype allele showed longer progression-free survival time (P log-rank = 0.04). ww-homozygous wildtype; wv- heterozygous; vv-homozygous variant.
Effects of SNPs on Disease Progression
In the NMIBC patients, 23 SNPs were significantly associated with progression (P<0.05, Table 3). After adjusting for multiple comparisons, one SNP, UNG:rs3890995, remained significant (Q = 0.08) and had a highly consistent result, with bootstrap P value <0.05 for 90% times of samplings (Table 3). The median progression-free survival times were longer than the follow-up time of 132.6 months for all genotypes (Figure 1 C). However, patients who carried the homozygous variant alleles had a 1.92-fold (HR 1.92, 95% CI, 1.33–2.77) higher progression risk (Table 3) and had decreased progression-free survival (log-rank test, P = 0.04; Figure 1 C). Due to the limited number of progression cases, we did not perform similar analysis in BCG-treated patients.
Effects of hsa-mir-421 and hsa-mir-1200 on NEIL2 Expression
Since one of the most significant SNPs, NEIL2:rs4639, is located in the gene's 3′UTR, we scanned the NEIL2 3′ UTR region for potential miRNA binding sites Targetscan (www.targetscan.org). Results showed that rs4639 allele is located close to a potentially weak binding site for the miRNAs hsa-miR-421 and hsa-miR-1200 (Figure 2). We cloned 3′UTR of NEIL2 and analyzed the effects of this SNP on the miRNA-mediated expression regulation. The two miRNAs had similar inhibitory effects on both wildtype and variant rs4639 expression (Figure 2), suggesting NEIL2:rs4639 might not affect targeting by these miRNAs.
Result of dual luciferase reporter assay showing the effects of rs4639 variant, hsa-mir-421 (−421), and hsa-mir-1200 (−1200) on reporter expression. All values were normalized to the Renilla luciferase activities and expressed as percentages of the luciferase activity for cells transfected with wild-type reporter construct and negative control RNA (Ctrl). Values are averages of five replicates with error bars for standard deviation. **, P<0.01 by Wilcoxon Ranksum test. Assay was repeated three times with similar results.
We evaluated the association of a panel of 276 SNPs in 38 oxidative-stress genes with the recurrence of NMIBC in patients treated with or without BCG. We identified 25 SNPs that were significantly associated with cancer recurrence in all (TUR- and BCG-treated) patients, 34 significant SNPs in TUR only patients, and 28 significant SNPs in BCG-treated patients. In addition, we found significant gene-dosage effects from the cumulative analysis, and identified one SNP associated with NMIBC progression.
The most significant SNP associated with recurrence in the BCG-treated group was NEIL2:rs804256, which is located in the intron region. Compared with the wild-type genotypes, the recurrence risk for the homozygous variant CC genotype was increased more than four-fold. However, this SNP was not significant in TUR only subgroup, suggesting a potential interaction of rs804256 with BCG treatment. Five out of six of the most significant SNPs are located in NEIL2, which highlights the importance of this gene in the recurrence risk. NEIL2 belongs to a class of DNA glycosylases homologous to bacterial Fpg/Nei family, which is essential for removing cytosine-derived lesions, particularly 5-hydroxyuracil and 5-hydroxycytosine [22]. It has been reported that two 5′-UTR polymorphisms decrease NEIL2 expression and increase mutagen-induced genetic DNA damage [23]. Downregulation of NEIL2 expression may lead to increased oxidative stress and genomic instability in rapidly proliferating tissues [24]. NEIL2 may also play important roles in repairing DNA damage induced by carcinogenic metals [25]. One of the most significant SNPs associated with recurrence, rs4639, is located in 3′-UTR of NEIL2. Luciferase reporter assay results showed that hsa-mir-421 and hsa-mir-1200 miRNAs had similar inhibitory effects on both wildtype and variant rs4639 expression. Since either miRNAs showed similar inhibitory effects on both wildtype and variant genotypes, it is possible that rs4639 may not be the causative variant but functions as a tagging SNP for other polymorphisms that may contribute to bladder cancer recurrence by altering NEIL2 expression or function. Alternatively, the variant allele of this SNP may affect targeting by other miRNAs. Future fine mapping of the regions surrounding the most significant tagSNPs are needed to identify the causal genetic variations and their molecular mechanisms.
We also identified a significant gene-dosage effect for the six tagging SNPs that showed significant main effects. Patients with the largest number of unfavorable genotypes had the highest risk of NMIBC recurrence, suggesting that additional risk genotypes within this key pathway were detrimental. This highlights the importance of assessing multiple SNPs within a shared pathway for clinical outcome assessment.
One polymorphism, UNG: rs3890995, was significantly associated with NMIBC progression. Rs3890995 is located 1.87 kb upstream of UNG 5′ UTR. One important function of UNG is to recognize and remove uracil from DNA by cleaving the N-glycosylic bond and initiating the base-excision repair pathway. DNA uracil comes from cytosine deamination or misincorporation of dUMP residues [26]. It is possible that the variant allele of SNP rs3890995 may affect gene transcription thus altering protein level. Alternatively, it may be linked to other causal variants in UNG.
In summary, we showed that genetic polymorphisms of the oxidative stress pathway genes may modulate the risk of NMIBC recurrence and progression in BCG treated patients. Further, we have conducted a relatively comprehensive query of the oxidative stress pathway polymorphisms with detailed clinical information and analyses, which provided substantial evidence for the involvement of this pathway in the clinical outcomes of bladder cancer patients, particularly with BCG treatment. There are some limitations in this study. For example, only Caucasians were included. It would be interesting to exam these SNPs in minority populations. Additionally, sample size is not particularly large, although power calculation showed that our analysis had sufficient power (>80%) to detect the main effects analyzed. Although our data are largely internally validated, future replication studies in independent populations are needed to validate some of the results and to translate the findings to clinical trials.
Supporting Information
Table S1.
Demographic and clinical variables for 421 NMIBC patients.
Table S2.
Oxidative stress gene SNPs and recurrence risk in overall NMIBC patients.
Table S3.
Oxidative stress gene SNPs and recurrence risk in NMIBC patients who received TUR only.
Table S4.
Oxidative stress gene SNPs and recurrence risk in NMIBC patients who received BCG treatment.
Author Contributions
Conceived and designed the experiments: HW CPD XW. Performed the experiments: HW HK JY. Analyzed the data: HW MC DWC XW. Contributed reagents/materials/analysis tools: AK HBG CPD XW. Wrote the paper: HW XW.
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text:
Imagine sitting down at an outdoor cafe in Marrakech, Tunis, or Tel Aviv. The air is perfumed with spice, and on the table in front of you sits a plate of something delicious, a glass of fresh mint tea, and a small jar of harissa.
Thick, vibrantly red, and lusciously textured, the piquant chile paste beckons you the way it has beckoned North African cooks for centuries.
Harissa has been at the center of Maghreb cuisine ever since New World explorers first introduced the Latin American pepper to Europe in the 16th century. (Scholars believe that chiles likely travelled to North Africa along with Spanish colonizers or roving spice traders.) With their beguiling flavor and easy adaptation to their new, sultry climate, Maghreb cooks quickly learned to love the chile pepper – particularly when pounded into an oil and spice-enriched paste that delivered fiery complexity to their food.
Today, harissa is a staple of Tunisian, Libyan, Algerian, and Moroccan cuisine. It is also revered in places like France and Israel, which are home to large populations of people from these countries.
In the United States, harissa is quickly gaining popularity as a flavorful alternative to condiments like ketchup, salsa, and sriracha, as well as a potent ingredient that amps the flavor of any dish it touches.
Like Italians with tomato sauce, home cooks across North Africa and the Middle East are serious about their harissa. Each cook has his or her own special method for grinding the chiles and blending in oil, garlic, and spices. That's why our harissa is bound to family tradition.
Our recipe is inspired by Ron's mother Linor, who was similarly taught how to make it by her mother after their family immigrated from Morocco to Israel.
But even more than heritage, what really sets our harissa apart is its pure flavor and composition. We never allow unnecessary ingredients like red bell peppers or tomatoes to bulk up the mixture. And we carefully source every ingredient that ends up in our jars, from the sundried chiles, white wine vinegar, and oil, to the toasted spices, and garlic. Most importantly, we work in small batches, producing no more than 100 jars of harissa at a time to ensure consistent and delicious quality in every spoonful.
Best American Artisans series; Food & Wine Magazine and Food. Curated have partnered
to produce a video about how and why we make our Harissa. Hope you enjoy watching!
Harissa comes from the Arabic word "to break," which likely stems from the mashing of the chiles. We blend three different chile varieties into each batch of our harissa. We start with juicy, slightly sweet Big Jims and deeply flavorful Sandias, which bring gentle heat and acidity to the mix. Both of these hand-harvested, sundried versions of these peppers are sourced from the good folks at Sichler Farms Produce, a renowned chile farm run by 5th and 6th generation growers near San Antonio. To round things out, we also incorporate Mexican-grown guajillos, which add a subtle chocolatey smokiness.
Back in our kitchen, we plump the chiles in hot water then press them through a hand-cranked food mill (which we believe might be a nod to the French influence on Moroccan cuisine) to form a brick-red paste that is completely free of distracting pepper skin and seeds. Unlike many jarred harissas, ours is completely smooth while still being full of body and texture.
So here is where things get really personal. How many spices should you use, and which ones? Which oil makes the best binder? How many cloves of garlic are too many? All harissa makers must answer these questions for themselves. Our motto is, let the chiles speak for themselves, incorporating just a few well-curated additions to enliven them and deepen their flavor.
On the spice front, we toast earthy cumin and citrusy coriander seeds until fragrant, then grind them up and blend them into the chile paste along with a drizzle of white wine vinegar. We think the promise of crunching down on the occasional nubby coriander seed is part of the pleasure of dipping into an NYSHUK Harissa jar.
As for the oil, Ron's Moroccan grandmother, Rachel Corcos, drizzled richly-flavored argan oil into her harissa. His mother used either argan oil or peanut oil, which was more widely available in Israel. Today we favor mild, GMO-free canola oil, which provides a silky richness, without overpowering the chiles' flavor. To finish, we soften fresh garlic in a little more oil until it turns mellow and sweet. Folded into the harissa, it offers a perfectly piquant undertone that brings the other ingredients together.
Harissa is a remarkably versatile condiment that can spice up anything from lamb kebabs to fried eggs. Growing up, Ron's family used it all the time – as a dipping sauce for fried fish, in traditional mashed potato and ground beef dumplings called popletas, in Moroccan carrot salads and fresh tomato salads, and to flavor chickpea dishes.
At home, try stirring a spoonful of NYSHUK harissa into soup for an extra kick of heat, or dilute it with oil to create a fragrant dipping sauce for bread or pita. Drizzle a little over hummus, grain salads, or roasted root vegetables; add it to marinades for chicken, beef, fish, or tofu; slather it on sandwiches, or dollop some onto a burger for an unforgettable twist.
Check out some of our recipes:
what they say about us...
"NYSHUK's harissa is dynamic with a subtle heat that gets balanced by the natural sweetness of the chilies. It is not technically meant to be eaten by the spoon, but you definitely will not regret it if you do."
- Chris E. Crowley | Serious Eats
At Daniel, we accented a dish of cedar wood-wrapped hamachi with NYSHUK's harissa and an eggplant and tahini emulsion. While not a traditional pairing, the harissa's deep, gently smoky flavor added incredible and unexpected dimensions to the dish.
- Eddy Leroux | Chef de Cuisine, Daniel | NYC
"Most bottled harissas are just intensely hot, but there's a rounded, roasted flavor to NYSHUK's version that is perfectly nuanced. One night we ran out during service, so we substituted some other store bought brand.
Customers noticed the difference and complained!"
Garett McMahan | Chef de Cuisine | Perilla, NYC
"Ron and Leetal's harissa is jammier, fruiter, and riper than any you've tasted before."
- Gabriella Gershenson | Wall Street Journal
As a professional cook, I have tasted other types of harissa and yours has an incomparable depth of flavor and a thick, velvety texture. I put it on almost everything now, honestly, it's addicting
- Rachel Nichols | chef @ The Smile | NYC
With the Mediterranean food craze sweeping the country, the Tunisian spice paste harissa might just become the next Sriracha - and NYSHUK's version is worthy of the designation.
- Kristin Donnelly | Zagat

subset: commoncrawl


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Joined: 09 Jan 2005
Posts: 568
Posted: Wed Mar 09, 2005 1:15 am
Post subject: If we trade down to 8-15 we should take...
In my hypothetical situation lets just assume that we pick up the other teams' 2 first rounders (Vikings, Chargers, Cowboys) or we pick up their first round and second round this year, (and perhaps a pick next year). Everyone who thinks we should trade down has been naming Heath Miller. I do not think that is a bad idea, but what about Thomas Davis. He is projected OLB/SS. Do we think he would play FS for one? Plus this way we can pick up our RB/WR/G in later in round 1 or 2.
Thanks so much Scar!!
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Joined: 28 Dec 2004
Posts: 258
Location: Illinois
Posted: Wed Mar 09, 2005 1:20 am
Post subject:
we have bigger needs on O to pick a slow safety or an undersized OLB when we need a big one who could shed blocks. adding Moose on O is not going to change everything - we need more help.
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Joined: 12 Jan 2005
Posts: 73
Location: chicago
Posted: Wed Mar 09, 2005 2:03 am
Post subject: If ronnie brown or dj goes.........
We need to trade out nobody else is worth that high of a pick. Williams cant run fast and we already have someone who cant run fast and is tall Gage. Edwards i dont think is the answer when we have too many holes. They are talking about q moving to guard but if we trade out of 4 and get 2 first we can either get heath miller another get target for grossman or cedric benson who is falling and a elton brown or david bass at guard for the next ten years then pick up a wr or running back in the second. also we should try to geet a third rounder from somebody maybe next years later draft for one in the third this year because we should try and get a good kicker or olb like a briggs
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Joined: 23 Nov 2004
Posts: 1528
Location: CA
Posted: Wed Mar 09, 2005 3:26 am
Post subject:
If Braylon or Williams are available I think that would have to be the best pick. If neither falls, I think if a RB is around (Benson, Cadillac though I dont really like him) we would jump on them as well. After that Heath Miller would be a good selection because he could def help both our running and passing games. Using a top 10 pick on him though I think would be a stretch. Taking a OT with this pick is probably out of the question with the Miller signing, but I think that might be the BPA.
Maybe another trade down, we could always use more first day picks?
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Joined: 07 Mar 2005
Posts: 20642
Location: Maryland
Posted: Wed Mar 09, 2005 9:51 am
Post subject:
Everything I've read says that GMs do not want to move up in the draft - they say there aren't any "can't miss" guys in this draft. So I don't see the Bears being able to trade down. No way do you waste the #4 pick on an OL, or a TE. Heath Miller just isn't good enough to pick at that slot either. I'm hoping that Ronnie Brown drops to us, but I doubt that he will.
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Joined: 07 Mar 2005
Posts: 48
Location: Crystal Lake, IL
Posted: Wed Mar 09, 2005 11:32 am
Post subject: Trading down
You people are nuts if you think we're walking away with 2 first rounders in a pottential trade. Think about it, why would a team like the Vikes or San Diego trade up when they're sittin' pretty with two "safe range" picks?
This draft doesn't have the buzz that previous drafts have had. There are no "sure picks", no Mannings or Moss' to trade up for. Teams like the Jets learned their lessons about trading up. I doubt we'll ever get lucky enough to trade a #4 (Dwayne Robertson) for two first rounders (Grossman and Haynes). The bust pottential (Robertson) scares too many people in this draft.
If anything we'll get a no.1, a third, and maybe a fifth. I would love the Bears to stay put and gamble on Mike Williams. Espeacially with the Vikes signing of Fred Smoot, the Bears could take adavantage of a division with short/undersized d-backs (Smoot and Winfield) by drafting a 6'5 monster in Williams.
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Joined: 07 Mar 2005
Posts: 20642
Location: Maryland
Posted: Wed Mar 09, 2005 11:46 am
Post subject:
I'm with ya Ryno... no way is anyone gonna trade up for the fourth pick. Take Williams and then we have a very good recieving corp between him and moose.
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Joined: 27 Jan 2005
Posts: 401
Posted: Wed Mar 09, 2005 12:02 pm
Post subject:
Payton34 - I may be proved wrong, but Mike Williams ever has or will be compared to Mike Williams. Copmpletely different.
Ryno, Grr - I would also be fine with a top receiver. I'd also like to see us take away the Vikings preferred pick of Williams (according to many mocks). I don't know who can create better separation between Edwards and Williams, but whoever that is- is who I want. My gut has always been Williams with his size and hands, but Edwards has been a star a the combine and since.
Overall, I'd like the best WR/RB available. Angelo, make your list and take whoever's left at the top.
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Joined: 09 Jan 2005
Posts: 568
Posted: Wed Mar 09, 2005 2:10 pm
Post subject:
Ryno- Robertson has not been deemed a bust yet, he is being considered to a rising star, we were fortunate to have Tommie Harris give some sort of production this year, because most DT's are not effective til they're third year. Secondly we essentially gave up Leftwich for Grossman and Haynes.
I understand, I more than anyone want to see Brown or Williams in a Bears uni next year, but the purpose of this thread was if we trade down. IF. then I just wanted to make a point that I don't think we should go Heath Miller. I would rather go Thomas Davis/ Troy Williamson type thing.
Thanks so much Scar!!
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Joined: 15 Feb 2005
Posts: 221
Location: The Friendly Village
Posted: Wed Mar 09, 2005 3:00 pm
Post subject:
if you guys remember it was terrell suggs the bears were looking at that pick but he ran a slow 40 time and thats why we traded down. i really hope we dont pass on an all-pro player in mike williams because of a 40 time again. but on this topic. i would have no problem with grabbing thomas davis and then possibly still getting a pass catcher. but i think we should snag a recieving te in miller. williamson's best trait is his outstanding deep speed but i think berrian has shown potential in that role. lets face it we have the worst te situation in the league, and miller even if he isnt tony g or gates, he would still be a major step up. great size, decent speed, and tremendous hands. but in all honesty lets not trade down. plus i think you can still find a decent wr in the later rounds.
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Joined: 07 Mar 2005
Posts: 20642
Location: Maryland
Posted: Wed Mar 09, 2005 3:15 pm
Post subject:
I don't see any chance of the Bears getting Miller... you can't take him with the fourth pick - he's not
good... and I really doubt that he'll be there in the second round. Again - no way are we trading down, because no other team is going to take the chance of giving up a middle first round and a second round for the fourth pick in the draft... there just isn't a marquee player worth it.
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Joined: 07 Mar 2005
Posts: 48
Location: Crystal Lake, IL
Posted: Wed Mar 09, 2005 4:01 pm
Post subject:
Delakev- I couldn't agree with you more on the subject of whether we should have traded down or not. However, the essential player we gave up (Robertson) is not worth Grossman and Haynes. However you're very right on the subject of who we passed on by trading. I was SREAMING draft Leftwich that year. THat's why I'm saying we should stay put at #4, not chicken out as ussual, and take our man. THe coaching staff loved Leftwich when he was coming out, but were too scared to take him at #4.
They've showed more balls this year by going out and getting they're respective targets in Moose and Mill, I feel (hope) they do the same with this pick.
Let it be known... If the Bears trade down this year I shall join Dekalev's boycott of the season.
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Joined: 09 Mar 2005
Posts: 152
Posted: Wed Mar 09, 2005 4:05 pm
Post subject:
Would it be stupid to take Williams at number four, then fill the gap at either OLB or safety wiht our second round pick, and then take a gamble on Clarret with our fourth round pick. Sure he is a headcase, but he has great talent and only ran a slow forty this year because he was too bulked up. This would allow the bears to get a qualitly WR and a chance at a star RB without trading up. Just a thought.
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Joined: 07 Mar 2005
Posts: 48
Location: Crystal Lake, IL
Posted: Wed Mar 09, 2005 4:15 pm
Post subject:
Canadian Bear- the only stupid thing you said was drafting Clarett. He has done nothing to impress me this offseason. All he had to do was look good at the combine and he failed at that. Now, with a crappy combine and an already alarming charactor isssues, he is nothing more than Randy Moss without the skills. And that my firend, isn't even worth a free-agent contract.
But other than that I agreed with everything you said
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Joined: 07 Mar 2005
Posts: 20642
Location: Maryland
Posted: Wed Mar 09, 2005 4:46 pm
Post subject:
I agree totally Ryno... Clarett is nothing but trouble waiting to happen (or to quit - like he did at the combine).
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Discussion in 'General Topics' started by Checkout, Mar 13, 2002.
Congrats on reaching a registered membership of 300! A very respectable figure!
oops..didn't notice that! Thanks We're up and running 4, maybe 5 weeks? nice!
That is an incredible growth!
It must be because this is the best security forum on the net.
Congrats from me also!
Thanks javacool . The quality of this board depends heavily on contributions from members and posters as well; on behalf of our team, thank you all!
And - spread the word! (grin).
Separate names with a comma.


text:
Get an overview of this hotel2- and 3-bedroom family resort 2 miles from Walt Disney World Resort
Popular property highlights
With a stay at WorldQuest Orlando Resort in Orlando, you'll be in a shopping district and convenient to Falcon's Fire Golf Club and Disney Springs™.
This condominium resort is within close proximity of Lake Buena Vista Factory Stores and Fun Spot America.
Make yourself at home in one of the 238 air-conditioned rooms featuring kitchens with refrigerators and microwaves. Rooms have private patios. Wired and wireless Internet access is complimentary, while DVD players and cable programming provide entertainment. Partially open bathrooms with separate bathtubs and showers feature jetted bathtubs and complimentary toiletries.
Be sure to enjoy recreational amenities including an outdoor pool and a fitness center. Additional amenities at this condominium resort include complimentary wireless Internet access, concierge services, and gift shops/newsstands. If you're planning a day at a nearby theme park, you can hop on the complimentary shuttle.
Grab a bite from a grocery/convenience store serving guests of WorldQuest Orlando Resort. While enjoying a refreshing dip in the condominium resort pool, you can order your favorite drink at the poolside bar.
Featured amenities include complimentary wired Internet access, a business center, and limo/town car service. Free self parking is available onsite.Information missing or incorrect? Tell us!Opens in a new window
WorldQuest Orlando Resort
Property Amenities
Property Amenities
WorldQuest Orlando Resort guests can swim in the large pool, which is surrounded by attractive landscaping, chaise lounges and a poolside bar. The condominium resort also features a clubhouse with a fitness center, plus a 24-hour food and sundries market. Free WiFi access is available in public areas and the resort has a business center and computer station (surcharge). A complimentary scheduled shuttle to and from Walt Disney World Resort is available, and a concierge desk is open from 7:30 AM until noon daily to sell theme-park tickets, make dinner and show reservations, and help plan excursions. A shuttle service is available (surcharge) to Premium Outlet stores, Seaworld and Universal Studios.
- 24-hour front desk
- Total number of rooms - 238
- ATM/banking
- Number of floors - 5
- Business center
- Concierge services
- Coffee/tea in common areas
- Free newspapers in lobby
- Elevator/lift
- Shopping center shuttle (surcharge)
- Free theme park shuttle
- Fitness facilities
- Gift shops or newsstand
- Computer station
- Grocery/convenience store
- Tours/ticket assistance
- Free wired Internet
- Laundry facilities
- Limo or Town Car service available
- Multilingual staff
- Garden
- Poolside bar
- Year Built 2006
- Free self parking
- Smoke-free property
- Number of buildings/towers - 7
- Outdoor pool
- Television in common areas
- Free WiFi
Family Friendly Amenities
- Family Hotel
- Outdoor pool
- Free Wi-Fi
- Kitchen
- Theme park shuttle (complimentary)
- Grocery/convenience store
- Laundry facilities
- Refrigerator
- Microwave
- Cribs/infant beds (complimentary)
- DVD player
Available in all rooms: Free WiFi , Free wired Internet
Available in some public areas: Free WiFi , Free wired Internet
Free self parking
Room Amenities
- Access via exterior corridors
- Air conditioning
- Television
- Desk
- Ceiling fan
- In-room climate control (air conditioning)
- Coffee/tea maker
- Free toiletries
- Cookware, dishware, and utensils
- DVD player
- Free local calls
- Hair dryer
- In-room safe
- Iron/ironing board
- Jetted bathtub
- Kitchen
- Cable TV service
- Free WiFi
- Dishwasher
- Microwave
- Patio
- Partially open bathroom
- Premium TV channels
- Refrigerator
- Second bathroom
- Separate bathtub and shower
- Separate sitting area
- Free cribs/infant beds
- Free wired Internet
Where to Eat
Tiki Bar – A poolside bar serving hamburgers, hot dogs, wraps, salads, and pizza.
Nearby Things to Do
The condominium resort has an outdoor pool and fitness center on site. The 18-hole Rees Jones-designed Falcon's Fire Golf Club is located two miles from the hotel.
The recreational activities listed below are available on site or nearby; fees may apply.
- Golfing nearby
If you have requests for specific accessibility needs, please note them at check-out when you book your room.
- Accessible bathroom
- In-room accessibility
- Roll-in shower
Property Policies
Check-in time ends at midnight
Check-in time starts at 4 PM
Minimum check-in age is 21
Check-out time is 11 AM
Payment types
Children and extra beds
- Children are welcome.
- Rollaway/extra beds are not available.
- Free cribs (infant beds)!
- Pets not allowed
You need to know
Extra-person charges may apply and vary depending on property policy.
Government-issued photo identification and a credit card or cash deposit are required at check-in for incidental charges.
Special requests are subject to availability upon check-in and may incur additional charges. Special requests cannot be guaranteed.
No rollaway/extra beds available
Parcel deliveries will be accepted only for guests in-house or prior to arrival. Deliveries received after a guest's stay will be returned. The hotel cannot be held responsible for lost or damaged goods. For more details, please contact the office using the information on the reservation confirmation received after booking.
- Cleaning fee: USD 39.00 per accommodation, per stay
- Towels/sheets: USD 6.00 per accommodation, per night
- Resort fee: USD 19.69 per accommodation, per night
- Fitness center access
- Shuttle service
- Newspaper
Optional extras
- Cleaning/housekeeping/linens fee: USD 39.00 per day
Property Name
- Orlando WorldQuest
- Orlando WorldQuest Resort
- WorldQuest
- WorldQuest Orlando
- WorldQuest Orlando Resort
- WorldQuest Resort
- WorldQuest Resort Orlando
- Worldquest Orlando Hotel Orlando


text:
How can a patch of grass be described as fast or slow? It's certainly not going anywhere! For those of you whose closest look at a golf green is from the car window as you're driving by, the speed of a green refers to how fast or slow a ball will roll on the green, the area of very short grass that contains the target hole. When your ball lands on a level slow green, a mighty rap might be required to get the ball to the hole. But on a level fast green, that same mighty rap could send the ball back off the green and into a sand trap!
Many factors determine the speed with which a ball will roll on the green, such as the length of grass and the direction in which the grass is growing and the wetness of the surface and underlying soil. Before they ever step on the first tee, both casual and serious golfers would like to know how fast the ball is going to roll on the green with a rap of a given force on that particular day. And they can, because of a simple measuring tool called the Stimpmeter®, which is described in Science of Golf: Kinematics.
This installment of the Science of Golf series, produced by NBC Learn in partnership with the United States Golf Association (USGA) and Chevron, is one of ten that highlights the science, technology, engineering, and math behind the sport. The companion NSTA-developed lesson plans help you use the sport to convey science concepts in an engaging, hands-on way. The videos are available cost-free on www.NBCLearn.com.
Download the lesson plans and use them as a base for your particular situation. If something works well (or not!) with your students, leave a comment and let us know.
–Judy Elgin Jensen
Image of green at the Tierra Rejada Golf Club in Moorpark, California courtesy of Dan Perry.
SOG: Kinematics discusses the importance of putting, the use of a device called a Stimpmeter® for determining the speed of a green, and how a branch of physics called kinematics applies to the use of this device.
STEM Lesson Plan—Adaptable for Grades 7–12
The lesson plan provides ideas for STEM exploration plus strategies to support students in their own quest for answers and as well as a more focused approach that helps all students participate in hands-on inquiry.The SOG: Kinematics lesson plan models how students can investigate a question about how one might design a system for determining the speed of greens in golf.
You can use the following form to e-mail us edited versions of the lesson plans:


text:
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HENGKO Technology Co., Ltd. is the excellent supplier in sintered porous metal filters ,metal breather vents , pneumatic exhaust muffler silencer. We are upholding " strict excellent product , considerate service " philosophy with partner customers growing together. HENGKO filter classification: Sintered muffler silencer: brass pneumatic exhaust muffler, brass speed control muffl...
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Company Profile
|Basic Information
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text:
While in Dublin be sure to visit the other National Cultural Institutions. We have the best of what Ireland has to offer in art, music, literature, theatre and history and have developed a series of exciting exhibitions, events and performances through which you can explore and engage in our rich cultural heritage. Explore Ireland's national treasures – there's something for everyone to enjoy!
Chester Beatty Library
Art Museum & Library featuring world-class exhibitions of Asian, Islamic and Western art.
Admission Free
Opening hours: 10am-5pm Mon-Fri; Sat 11am-5pm; Sun 1-5pm
Closed: Mon Oct-April
Chester Beatty Library Dublin Castle, Dublin 2
T: +353 (01) 407 0750| www.cbl.ie | email@example.com
Crawford Art Gallery
A fine art museum, with a collection spanning the eighteenth century to the present, including Graeco-Roman casts and Neo-Classical sculptures and contemporary Irish.
Admission Free
Opening hours: 10am-5pm Mon- Sat (4.45pm last entrance)
Crawford Art Gallery, Emmet Place, Cork
T: +353 (0)21 480 5042|www.crawfordartgallery.ie | email@example.com
Irish Museum of Modern Art
Ireland's leading national institution for the collection and presentation of modern and contemporary art.
Opening Hours:
Tues – Sat 10am – 5.30pm; Wed 10.30am – 5.30pm (Last entrance 5.15pm)
Closed Mondays
Irish Museum of Modern Art, Royal Hospital, Military Road, Kilmainham, Dublin 8
T: +353 (01) 612 9900, | www.imma.ie | email@example.com
National Archives
The National Archives preserves and makes accessible Ireland's state archival heritage dating back to the 14th- century.
Admission free
Opening hours: 10.00 – 17.00 Monday – Friday
National Archive, Bishop Street, Dublin 8,
T: + 353 (0)1 407 2300 / Lo Call: + 353 1890 252424 |
www.nationalarchives.ie | firstname.lastname@example.com
National Concert Hall
The National Concert Hall is the premier classical music venue in Ireland hosting weekly performances by the resident RTÉ National Symphony Orchestra and hosting a wide range of classical, jazz, world-music, contemporary and traditional music concerts.
Tickets prices: varies depending on concert
Box Office Opens: Mon – Sat 10am – 6pm
(open two hours prior to a concert on Sundays/Bank Holidays)
National Concert Hall, Earlsfort Terrace, Dublin 2
Box Office: + 353 (01) 417 00 00 | www.nch.ie | firstname.lastname@example.com
National Gallery of Ireland
The Gallery houses the national collection of Irish and European fine art, a National Portrait Collection and room dedicated to work by Jack B. Yeats. Admission free
Opening Hours
Mon – Sat 9.30am-5.30pm; Thurs 5.30pm-8.30pm. Sun 12.00pm-5.30pm. Public Holidays 10.00am-5.30pm.
National Gallery of Ireland, Clare Street, Dublin 2, Ireland
T: + 353 (0)1 661 5133 | www.nationalgallery.ie | email@example.com
National Library of Ireland
Collecting, preserving and sharing Ireland's print, visual and manuscript collections and genealogical material.
Admission free
Opening Hours:
Mon – Wed9.30am – 9pm; Thurs & Fri 9.30am – 5pm; Sat9.30am – 1pm (exhibitions open until 4.30pm)
National Library of Ireland, Kildare St., Dublin 2
T: +353 (01) 603 0200 | www.nli.ie | firstname.lastname@example.com
National Photographic Archive
Showcasing Ireland's historical and contemporary photographic collections
Opening hours:
Mon – Sat: 10.00am – 4.45pm; Sun: 12.00pm – 4.45pm
Meeting House Square, Temple Bar, Dublin 2
T: +353 (01) 603 0200 |www.nli.ie |email@example.com
National Museum of Ireland
Ireland's premier cultural institution and home to the greatest collections of Irish material heritage, culture and natural history
Admission Free
Decorative Arts & History: Displays and wide range of artefacts charting Ireland's economic, social, political and military progress through the ages.
Collins Barracks, Benburb Street, Dublin 7
Tel: +353 (0) 1 6777444| www.museum.ie | email@example.com
Archaeology: The home for all archaeological objects found in Ireland and artifacts dating from 7000BC to the 20th Century.
Archaeology, Kildare Street, Dublin 2
Tel: +353 (0) 1 6777444| www.museum.ie | firstname.lastname@example.com
Natural History: Exhibits of animals from Ireland and overseas, geological exhibits from a total collection of about 2 million scientific specimens.
Merrion Street, Dublin 2
Tel: +353 (0) 1 6777444| www.museum.ie | firstname.lastname@example.com
Country Life: A unique opportunity to see how the people of Ireland lived in the hundred years between the Great Famine and the end of the 1950s.
Turlough Park, Castlebar, Co. Mayo
Tel: +353 (0) 94 9031755 | www.museum.ie | firstname.lastname@example.com
Opening Hours
Tues – Sat: 10am – 5pm; Sun: 2pm – 5pm; Closed Mondays
The Heritage Council
Works with communities to propose policies and priorities for the identification, protection, preservation and enhancement of the national heritage.
Opening hours
Mon – Fri: 9am – 5pm
The Heritage Council, Áras na hOidhreachta, Church Lane, Kilkenny
T. + 353 (0) 56 777 0777 | www.heritagecouncil.ie | firstname.lastname@example.com
Ireland's National Cultural Institutions offer a wide range of education and access programmes. Visit each organisations website or visit www.cnc.ie for more information.


text:
DANNY Stokes grew up watching Scooby Doo, so imagine his delight when he was cast as the hapless Shaggy. The 28-year-old actor talks about the new show coming to the Swan this month and filming an advert for the World Cup.
Scooby and the gang are coming to High Wycombe in a new stage show, Scooby Doo - The Mystery Of The Pyramid. Transported to ancient Egypt they face treacherous challenges while trying to uncover the mystery of Pharaoh Hatchepsout's pyramid.
The show is faithful to the animations- with the signature theme song and spectacular effects.
Danny said: "I have been a fan of Scooby Doo since I was very young.
"Before I used to go to school I used to watch Scooby Doo and Wacky Races in the morning.
"Shaggy was always my favourite character.
"My agent called me and he was so excited. He said: 'I have got you an audition. It is Scooby Doo and for Shaggy!'"
The actor, who graduated from the Birmingham School of Acting in 2009, has done a lot of character acting throughout his career and is used to doing impressions.
He watched a lot of the films and animations, and has even perfected the unique way the mystery solving team run.
As for Shaggy's voice, he said: "I started with Kermit the Frog and broke his voice a bit and you're there."
And to get into the role, he went to the audition wearing the red and green colours of Shaggy.
Danny said: "It is such a well known character to so many people.
"It is a lot to kind of take on board- so many people are aware of his characteristics.
"It is a strange feeling."
Eddie Arnold will lead the cast as Scooby Doo, Julia Cave in the role of Daphne, Louise Wright as Velma, and Josh Little playing Fred.
They will be joined by actors Douglas Walker as Otto, Stuart Vincent as Ben, Eleanor O'Grady as Mira, and Phillip Quigley as understudy and resident Dance Captain.
Danny said: "I think the kids will really enjoy it and find it really funny. Eddie as Scooby is fantastic- the costume and the way he looks and the way he moves.
"There is enough nostalgia there to keep adults interested as well.
"I think it is fantastic and can't think of anybody who wouldn't enjoy it.
"Even though everyone says it is always easy to guess who did it, everyone enjoys trying to guess.
"Everyone tries to guess who it is, while enjoying the ride."
Last year he filmed an episode of Silk for the BBC and also starred in Doctors.
And this summer his face will be seen across the world in a Pringles advert for the World Cup.
He said: "We all leave drama school. I think we have these little aspirations- you don't tell anyone.
"It is nice to say you are doing something a lot of people are going to see."
For now, Danny will be focusing on playing Shaggy in this tour.
He said: "This is an absolute dream to work on such a good production."
Scooby Doo, The Mystery of the Pyramid, is at the Wycombe Swan on April 7 at 6.30pm and April 8 at 1 and 4.30pm. Tickets are £15.50 to £20.50 with a £1.50 booking fee from 01494 512000 or go to www.wycombeswan.co.uk.


text:
Beginner Crochet Baby Afghan by Lion Brand Yarn
Welcome! You are browsing as a guestWould you like to see 37 projects made from this pattern and much more? create a free account What am I missing?
© Lion Brand Yarn
Beginner Crochet Baby Afghan
This pattern is available for free.
Crochet these squares in Jamie, and watch the soft colorful blocks become this cuddly baby afghan. Sew the squares together into the finished project, or use a hook to crochet them together. (LionBrand.com)
SKILL LEVEL: Beginner
SIZE: One Size
About 26 x 33 1/2 in. (65 x 85.5 cm)
#881 Jamie
2 balls each of 5 colors (10 balls total):
Blue Bonnet, Sunshine, Peachy, Little Boy Blue, Angel White
Crochet Hook - Size H-8 (5 mm)
Work four squares of each color in half double crochet (20 squares total). Sew squares together as shown in diagram.
Free registration at LionBrand.com required for access to pattern.
For more information, see: http://www.lionbrand.com/patterns/L10267.html


text:
by Staff Writers
Beijing (UPI) Aug 19, 2013
Extensive hydropower development in the upper reaches of China's Yangtze River poses a threat to the future safety of Shanghai's water supply, says a new study.
The report, by Yangtze River Fishery Resources Committee under the Ministry of Agriculture and World Wide Fund for Nature, known as WWF, is based on a scientific expedition by 32 researchers from government agencies and NGOs through five provincial regions carried out in June.
"One of the most direct consequences for Shanghai is the reduction of the total amount of fresh water that flows from the upper reaches," Yong Yi, a project manager at WWF's Shanghai office, was quoted as saying by the Global Times. "This will cause water safety problems for Shanghai, because the coastal city will suffer from seawater intrusion."
As part of China's energy plan, more than 25 hydropower stations are planned along the 1,434-mile long Jinsha River, one of the major headwaters of the Yangtze. The facilities will be about 62 miles apart and together will supply power equivalent to four times the amount of China's massive Three Gorges Dam project, the world's largest power station that has an installed capacity 22,500 megawatts.
At least 12 of those stations are already under development, and that construction has tamed the Jinsha's once-powerful current that had carried silt down to the Yangtze's lower reaches, the report notes.
"The sand and soil are very important for Shanghai, which sits on the tip of the alluvial plain of the Yangtze River Delta," Yong told the Global Times. "With the Yangtze River carrying down less sand and soil, the tidal flat will shrink. The flat is considered an important land reserve."
The report also warns that the fish ecosystem on the Yangtze -- the longest river in Asia and the third-longest in the world -- is on the verge of collapse due to increasing development and overfishing.
The number of Yangtze's fish in four major species has dropped from more than 30 billion in the 1950s to less than 100 million, the report says. Furthermore, the number of breeds has shrunk from 143 to 17.
"The source species are reducing, leading to unsustainable development of aquaculture and an increasingly fragile ecosystem," Zhao Yimin, head of the Yangtze River Fishery Resources Committee, was quoted as saying by China Daily. Already some species, such as the fin-less porpoise, have become extinct.
Environmentalists and scientists have called for a ban on fishing along the Yangtze River to give time for the ecosystem to rebuild itself.
Related Links
Water News - Science, Technology and Politics
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text:
Beaches at Bandy Creek Boat Harbour have been closed by the Department of Transport and the Shire of Esperance due to pollution.
An oily substance, suspected to be diesel, was observed by a member of the public on the surface of the water at the beach on the town side of the groin on Wednesday morning.
As a precautionary measure, the Shire of Esperance and Department of Transport closed the beaches at about 8.30am on Thursday.
The cause of the contamination is yet to be determined.
The Shire of Esperance Chief Executive Officer Matthew Scott said the shire had closed a number of beaches within the Bandy Creek Boat Harbour on Thursday as a precautionary measure to protect the public from a suspected minor diesel spill that was reported and investigated late Wednesday afternoon.
Read more - The Esperance Express


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Farfalle & Basil Pesto
Helen's Kitchen Serves Up a Bit of Amore
This Italian meal exposes taste buds to a gondola-ride of subtle flavors, which tosses together Helen's Tofu Steaks with an Italian farfalle pasta and pesto sauce (made from fresh basil, parmesan cheese and extra virgin olive oil).
This delectable meat-free meal provides a complete balance of protein, calcium, vitamins C, iron and fiber, with zero trans-fat, MSG, and GMOs.
Savor every bite, and remember Helen's Simple Health lifestyle is about making Smart Choices and Enjoying Life through Delicious Organic Gourmet Food that is simple to prepare and provides Balanced Nutrition.


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A brand new trailer of 'Tenderness', a John Polson's psychological thriller starring Russell Crowe, has been released by Lionsgate Films U.K.
Lionsgate Films U.K. have debuted the first look into "Tenderness" with the release of the film's trailer. Less than two minutes long, the video gives away a background story to the movie as well as displays footage introducing its four major characters played by Russell Crowe, Jon Foster, Sophie Traub and Laura Dern.
Set in New York State, "Tenderness" takes its focus on juvenile murderer by the name of Eric Poole and hard-bitten detective Cristofuoro. Having served his sentence for a young girl's murder, Poole is released from jail at the age of 18-year-old.
When he embarks on a road trip up-state, Cristofuoro who believes that Poole is a potential serial killer keeps him under his watchful eyes. But, all is not as it seems as Poole soon finds himself on the run with a 16-year-old girl, Lori, who could have been witness to the first murder and has become obsessed with him.
Directed by "Hide and Seek" helmer John Polson, the psychological thriller is penned by Emil Stern from Robert Cormier' novel. The movie sees Russell Crowe stars as Cristofuoro, Jon Foster as Eric Poole and Sophie Traub as Lori. It is yet to have its U.S. release date.
"Tenderness" U.K. Trailer:


text:
Identity Theft: Grave Robbing for a Tax Refund
Five-year-old Benny Watters died of a brain tumor in September 2010. Ten months later, his parents tried to e-file their 2010 tax return listing him as a dependent, only to have the IRS block it based on information that made the family sick: Someone else had applied for a refund claiming him as their child. "It was almost like somebody had stolen him from us," says his mother, Lisa Watters, of Lake Forest, Ill.
Watters went online looking for answers about how the crime could have happened. Within a few clicks she came upon Benny's Social Security number, in a list released by the federal government. "It's just so easy [to find], and I don't know what purpose it serves," Watters says.
Known as the Death Master File, the list is compiled by the U.S. Social Security Administration and contains birth dates and other sensitive information on more than 89 million deceased. The government doesn't put the file on the Internet itself. It sells the records to local governments, hospitals, pension funds, and private companies. Because the list is considered public information, it's legal for any buyer to post it online.
That means criminals don't have to look very hard for names and numbers to poach. Thieves can file a fraudulent return either by claiming false income or false dependents, and request that a refund be deposited onto a prepaid debit card. Nina Olson, the U.S. Taxpayer Advocate, has called it a "relatively new tactic" in the realm of tax-related identity theft, which the IRS says has ensnared more than 490,000 victims since 2008. Once the IRS dispatches the money to a debit card, it's hard to trace.
Social Security Commissioner Michael Astrue has said it will take an act of Congress to restrict the death file's release to companies that meet a set of qualifying standards—which a bill introduced in the U.S. Senate would do. Yet credit reporting agencies, insurers, and other industries worry the legislation could slow their efforts to check names against the file to prevent other types of identity theft. "The faster that we can get it and the more current that information is, the more likely we can prevent the fraud that occurs in that early window right after someone dies," says Stuart Pratt, chief executive officer of the Consumer Data Industry Association, a Washington-based lobbying group.
Watters says it took until January 2012 to get her tax return processed correctly. The IRS wouldn't tell her who filed the fake return with Benny's information or whether the criminal was prosecuted. The agency says federal privacy laws prevent it from releasing that information. "The IRS takes this issue very seriously and is taking special steps to assist people caught in this situation," IRS spokesman Terry Lemons says. To prevent tax fraud, the government is using new automated filters to detect suspect returns involving the deceased. That process has flagged 91,000 questionable returns for further review so far this year.
Jonathan Agin, a lawyer from Arlington, Va., whose deceased four-year-old daughter's Social Security number was also stolen, says he wants the death file to stop being "served up on a silver platter" to thieves. Agin says he posted about the theft on social networks for parents of children with cancer last year and heard from 14 other families with the same problem within an hour. "It's bad enough when you lose your child," he says. "Then to have their identity taken and utilized, it's just a compounding injury to a family. That's something that I don't think a lot of people understand."
The bottom line: The IRS is reviewing the tax returns of 91,000 deceased Americans this year on suspicion of identity theft.


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|Scour.com invite from miguel rosa
|miguel rosa<>
|Thu, 24 Jul 2008 11:37:27 -0700 PDT
Hey, Did you hear about Scour? It is the next gen search engine with Google/Yahoo/MSN results and user comments all on one page. Best of all we get paid for using it by earning points with every search, comment and vote. The points are redeemable for Visa gift cards! It's like earning credit card or airline points just for searching! Hit the link below to join for free and we will both get points! http://scour.com/invite/lram/ I know you'll like it! - miguel rosa
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text:
The troubled $6 billion Oakajee Port and Rail project in Western Australia's mid-west has officially been shelved, leading to more job cuts. The owner – Japan's
Oakajee Port and Rail and Crosslands chief executive officer
"Progressing partnership discussions for the mine, port and rail project in the current economic environment for commodities is particularly challenging, and is probably now harder than it was in November 2012 when the decision was made to reduce expenditure on the project," Mr Langoulant said in a statement.
Mr Langoulant told AFR Weekend he remained an "optimist" about the possibility the project would eventually be developed. "The state government remains very committed to the development of the port," he said.
The decision comes after Western Australian Premier
Seventy-one employees from Oakajee and Jack Hills were expected to be made redundant following the announcement in November. Another 15 workers will be made redundant as a result of Friday's announcement. The project will retain seven workers for care and maintenance.
"Karara has always been a supporter of Oakajee Port, but we have not been reliant on Oakajee," said Gindalbie chief executive
"We've invested more than $200 million at Geraldton Port, which gives us capacity for stages one and two.
"We believe Oakajee will be developed some time in the future, but in the event of long-term delays we believe there are potential further opportunities at Geraldton for a long-term player like Karara."
The Australian Financial Review


text:
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text:
somewhere on facebook I saw a post that the books written by Pandit Shakar Ghosh (in Bengali as far as I know) will be translated into english.
Does anyone know something about that?
Pandit Shankar Ghosh Tabla Books
Discussions about the Indian percussive instruments.
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text:
Regional Reviews: St. Louis
And, like the Wallendas, the safety net for these self-assured young Hollywood producers gets rolled-up and hauled away, for added drama. It happens when a lovely young secretary begins asking some awkward questions: "Why does Hollywood have to make bad movies?" being chief among them. Sigrid Sutter is Karen the outsider, a temporary stenographer who gets handed an over-wrought novel that might possibly be turned into an evanescent art house film. Unless, of course, Michael James Reed, as bare-knuckles, back-lot conniver Charlie Fox, can rely on the bonds of Hollywood's old boy network to turn it all around to his own good fortune.
Mr. Reed has a blaze inside that leaves him dripping in sweat most of the way through this 1988 drama, filled with the usual near-misses of dialog, as the characters try to make their trapeze-like connections, well over the heads of their movie-going public. He spends a good 2/3rds of the play cosseting and cajoling Christopher Hickey, as Bobby Gould, a junior executive at an unnamed studio out west. Bobby is more of a human super-computer, processing incredible amounts of informationweighing Charlie's package-deal movie, featuring some of Hollywood's biggest names, against his temp secretary's beautiful and impassioned plea for that art house film.
It's Reed's incomparable anguish and excitement that speeds this play to its rough-and-tumble conclusionwith Mamet's usual flourish of violence and misogyny at no extra charge. And, after Karen makes her glorious pitch for a story of human transfiguration at the end of the world, Charlie goes into full attack mode on behalf of a buddy picture that begins with a fantasy of gang rape behind bars. Caught between those two competing visions, Bobby is left spinning in mid-air, not knowing which way to turn. It's a great, fast-paced story of the spirit versus the flesh, with a Hollywood-ending guaranteed ... one way or another.
There's also a lovely bit of a time capsule at work herethe New Jewish Theatre has never done a Mamet play before, and much of its regular audience is quiet, older, thoughtful and convivial, like the Broadway audiences of old. As a result, you actually get some of those same reactions of shock all around you, to the "edginess" of 25-year old Mamet, without ever having to plunge into the latest, 21st century version of human degradation on stage. It's strangely charming, like the 1980s suspenders the men wear, and like that same era's unquestioning self-assurance: that each one of us is secretly the smartest, wisest, and manliest man in the room.
Through February 24, 2013, at the Jewish Community Center, #2 Millstone Campus Drive, a block west of Lindbergh and Schuetz (between Page and Olive Blvds.). For more information visit www.newjewishtheatre.org or call (314) 442-3175. There are no Friday performances.
* Denotes Member, Actors Equity Association, the union of professional actors and stage managers in the US.


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|White Chocolate Pudding Cake
I have had a boxed yellow butter cake mix sitting in my cupboard for several weeks. I don't know about you, but I am one of those bakers who feels semi-guilty when I bake something from a boxed mix. I like to keep one on hand though in case I need something spur-of-the-moment.
In this case, I had a craving for cake at about six o-clock at night. It was too late to start something from scratch (with an almost two year old child, we go to bed early in our house). At the last minute I remembered a recipe I had saved on allrecipes.com.
Since I didn't have any instant pistachio pudding mix in my house, I went straight for my staple: instant white chocolate pudding mix. I used vanilla extract instead of the almond and skipped the food coloring altogether. Just to be a little different, I baked the cake in a nine inch springform pan. Once cooled, I covered the top and sides of the cake with Betty Crocker milk chocolate frosting.
The result? A deliciously moist cake with just enough hint of white chocolate to satisfy my husband and I. The milk chocolate frosting is the perfect compliment to the yellow cake. This one is going in my recipe box…I just can't wait to try other combinations of pudding flavors!
|The cake is done baking when a toothpick inserted in the center comes out clean.
It took exactly 55 minutes for this to occur in my springform pan.
|milk chocolate frosting surrounding the tall cake
|a nice tall slice cut out of the center of the cake
White Chocolate Pudding Cake
Prep time
Cook time
Total time
Serves: 12
- 1 (18.25oz.) box yellow butter cake mix
- 1 (3.4oz.) pkg. instant white chocolate pudding mix
- 4 large eggs
- 1&1/4 cups water
- ¼ cup vegetable oil
- 1&1/2 teaspoons vanilla extract
- ------------
- frosting of choice
- Preheat oven to 350 degrees. Place all ingredients in a large bowl.
- Beat on low speed for 1 minute. Turn to medium speed and beat for 4 additional minutes.
- Pour into a greased and floured 9 inch springform pan. Bake for 55 minutes or until a toothpick inserted near the center comes out clean.
- Cover cake with frosting of choice.
*If using something other than a springform pan, remember to adjust bake times accordingly.


text:
Ask Mac Questions and Get Answers from Experts ASAP
if that doesnt work,go to app store on your ipad and download photon browser
used photon browser and go to that link www.good-ear.com
I've got the Photon app but the quicktime is still not working
Must go now. Logging off. Thanks for trying!
you're welcome
please email Justanswer account and billing, they will gradly help you closed this question.remember I dont get paid until you click accept. so dont worry about it
no problem at all, sorry I cannot help you any further


text:
Kelley Hopkins-Alvarez, LPC,NCC,BCC,MS,MSEd
Licensed Professional Counselor & Board Certified Coach
Stamford, Connecticut 06901
Couples need a therapist they can trust. I have trained with the world's leading couples therapists, John Gottman & Sue Johnson. Researched-based, proven methods for dealing with intimacy, trust, emotional or physical infidelity, communication, and/or parenting issues.
Dr. Adina Goldstein, DSW, LCSW
Licensed Clinical Social Workwe
123 Harbor Drive. #706, Stamford, Connecticut 06902
With over 25 years experience my practice offers practical solutions for a variety of couples/family problems through improving communication, intimacy, and empathy. I can help you with issues concerning infidelity, rebuilding trust, and dealing with anger.
Kevin Fleming Ph.D.
Coach/Change Agent/Consultant
Greenwhich, Connecticut 06870
Though we are not licensed marriage counselors, Grey Matters International, Inc. provides cutting edge brain optimization and rebalancing technology to better align the minds of partners to reduce conflict, increase hope---for the brain has the final word on change.
Theresa Evans Knight, MA, LMFT, MBA
Licensed Marriage and Family Therapist
37 Cranbury Road, Suite 102, Norwalk, Connecticut 06851
Partnerships and marriages are monumental commitments. I work with traditional and non-traditional couples in developing better lines of communication, respect and appreciation for the partner or spouse that they initially fell in love with.
The Imago Way, Psy.D. & L.C.S.W.
Licensed Psychologist & Licensed Social Worker
550 Mamaroneck Avenue, Suite 305, Harrison, New York 10528
We work with couples to help them reconnect by breaking destructive patterns of relating and teaching them specific strategies to communicate more effectively.
Donna Schinik, L.C.S.W.
Licensed Clinical Social Worker
311 North Street - ste. 203, White Plains, New York 10605
I provide couples and family therapy in addition to individual work. Learning to open the lines of communication in a constructive manner is often the key to change in a relationship. Together we can explore more effective ways to relate to loved ones.
Joyce Colburn, LCSW
Licensed Clinical Social Worker
225 Main St., Westport, Connecticut 06880
I work with both couples and families who are experiencing stress, anxiety, anger, conflict, and communications problems in their marriages and family dynamics.
Stephanie Burchell, PhD, LMFT, CFLE
Licensed Marriage & Family Therapist
215 Main Street, Westport, Connecticut 06880
For 10+ years, Dr Burchell specializes in helping couples regain closeness, overcome distress, improve communication and repair emotional injuries. Certified in Emotion Focused Couples Therapy, Intensive sessions and Discernment Counseling are also offered.
Paula Levy, MA, LMFT
Licensed Marriage & Family Therapist
3 Sylvan Road South, Westport, Connecticut 06880
Paula Levy, Marriage Counselor and Couples Therapist, works with you to save, repair and grow your relationships. She works with individuals, couples and families who have been impacted by divorce, affairs, communication or intimacy issues. Love grows here!
Louis Morbillo, LCSW, ACSW
Licensed Clinical Social Worker
53 E. Main Street, Oyster Bay, New York 11771
My approach to Marriage and Family is simple: focus on improving communication. My goal is to facilitate that communication and help navigate the complexities of each individual circumstance.
G&G Counseling Services, LCSW, LMHC
LCSW and LMHC
280 Dobbs Ferry Road, Suite 200, White Plains, New York 10607
A healthy marriage takes work. Therapy will reach the heart of the issues and begin the process of restoration. Let's get started.
Nassau Wellness, Couples Therapy
Marriage and Family Therapists
75 Prospect Street, Huntington, New York 11743
We offer caring and supportive marriage counseling to couples in all stages, from premarital counseling to amicable divorce therapy. Our therapists are passionate about relationship work and have specialized training in this area.
Walter Masterson, LCSW
Psychotherapy and Counseling
Home visits , Suffolk County, New York 11743
Careers and children place enormous strains on a couple's ability to be together in an intimate and satisfying way. Every couple has different ways of coping with the challenges, and counseling can provide the perspective and encouragement to re-create a shared vision.


text:
Alderson, Priscilla and Goodey, Chris (1999) Autism in special and inclusive schools: 'there has to be a point to their being there'. Discourse and Society, 2. pp. 249-261. ISSN 0957-9265. DOI UNSPECIFIEDFull text not available from this repository.
|Not from UCL IOE?
|Item Type:
|IOE Departments > Departments > Social Science Research Unit
|Depositing User:
|IOE Repository Editor (2)
|Date Deposited:
|19 May 2010 10:59
|Last Modified:
|29 Jan 2015 08:11


text:
J. Edgar
Leonardo DiCaprio stars in this riveting biopic as J. Edgar Hoover, the longtime FBI director as notorious for his overzealous methods of law enforcement as for the rumors regarding his cross-dressing and close relationship with protégé Clyde Tolson.
Rent DVDs for only $4.99 a month.
Movie Details
- Director
- Clint Eastwood
- This movie is
- Dark
- Format
- DVD, Blu-ray and streaming
- Awards
- 2012 Golden Globe Awards
- Best Actor in a Motion Picture (Drama) nominee: Leonardo DiCaprio
- Ratings
RBrief strong language
15Common Sense rating OK for kids 15+
DVD details
Blu-ray details
Widescreen 1.85:1Subtitles
English SDH, French, Spanish (Neutral)Closed captioned
NoLanguage and sound
English: Dolby Digital 5.1, French: Dolby Digital 5.1Other features
Color; interactive menus; scene access.
Widescreen 2:40:1Subtitles
English SDH, Spanish (Neutral)Closed captioned
NoLanguage and sound
English: Dolby Digital 5.0Other features
Color; interactive menus; scene access.
J. EdgarClose
For Parents
Common Sense Note
Parents need to know that this Clint Eastwood-directed biopic about longtime FBI Director J. Edgar Hoover (played by Leonardo DiCaprio) is rated R primarily for a couple of brief but notable scenes of strong language (including "f--k"). J. Edgar focuses on both Hoover's career and his personal life, especially the never-defined relationship with longtime companion Clyde Tolson (Armie Hammer). While the movie raises questions about Hoover's sexuality that it doesn't answer, there's no actual sex in it (though one scene features apparent recorded noises of an amorous couple). Expect a few violent fist fights and shoot outs.
- Sexual Content
- The undefined nature of Hoover's relationship with his assistant makes the question of sex, and sexual identity, an important part of the film. One scene involves a surveillance audiotape that seems to have recorded the sounds of people having sex.
- Violence
- A few scenes feature fist fights and shoot outs.
- Language
- Infrequent swearing; when the words "c--ksucker" and "f--king" are heard (in two scenes), they stand out since the rest of the film is so lacking in profanity. Also "for God's sake" as an exclamation.
- Social Behavior
- The message at the heart of J. Edgar is to be true to yourself, or every part of your life will be based on a false foundation. The movie suggests that Hoover's inability to be honest about his own identity possibly contributed to an excess of zeal in criminal investigations of sometimes questionable legality.
- Consumerism
- Not applicable
- Drugs / Tobacco / Alcohol
- Some social drinking, though Hoover was a teetotaler and actively discouraged people from drinking, on and off the job. Some smoking (accurate for the time period).
- Age appropriate
- Not an issue
- Depends on your kid and your family
- Not appropriate for kids of the age most likely to want to see it


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Tickets are no longer available online but can be purchased for $50 at the door.
Join us for an update from Staff Attorney Karen Loewy on our current civil rights work in New Jersey and across the country while enjoying cocktails, hors d'oeuvres and a relaxing afternoon at this house party.
For more information, please contact Joe Foster at 212-809-8585, ext. 250.
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2007 1040 IRS Audit Notice Letter
This is a sample of an IRS 1040 Audit Notice received from one of our members. Personal information has been redacted to protect our member's privacy. If you received a letter similar to this one or any notice from a state taxing agency or the IRS, we can help you!


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180% rise in foot patrols
Scott Simpson
MP For Coromandel
11 February 2014
180% rise in foot patrols
Coromandel MP Scott Simpson says a 180 per cent increase in police foot patrols across the Waikato over the last two years is preventing crime and making people feel safer in their homes and communities.
Crime in Eastern Waikato fell by 11.8 per cent in 2012/2013 when New Zealand reported its lowest crime levels in 30 years.
"Our focus has been on assisting our police to be an active, visible presence in our communities. Central to that support has been providing them with the tools to do that," Mr Simpson said.
"Following last year's rollout, frontline officers now have smartphones and tablets, which allow them to spend on average an extra 30 minutes per shift out of the station. Nationally, this is the equivalent of an additional 354 frontline staff, and is delivering over half a million additional frontline Police hours per year."
As well as acknowledging the great work of our local officers, Mr Simpson also praised all those who support the work of the police across our Coromandel communities.
"I had the great privilege of spending some time with one of our Community Patrol groups recently. They are a huge asset to our local police, particularly in our smaller towns where they do tremendous work in terms of gathering and reporting information and monitoring the safety of people and property."
"Driving down crime is not just about the actions of the police. We can all play a part by being vigilant in relation to our own security and that of our property. Reporting suspicious activity as soon as it occurs is also vital as it provides the best possible opportunity for police to prevent a crime occurring in the first place."