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The display and use of drug information on this site is subject to express terms of use. By continuing to view the drug information, you agree to abide by such terms of use.
GENERIC NAME: HALOBETASOL - TOPICAL (HAL-oh-BAY-ta-sol)
BRAND NAME(S): Ultravate
Medication Uses | How To Use | Side Effects | Precautions | Drug Interactions | Overdose | Notes | Missed Dose | Storage
USES: This medication is used to treat a variety of skin conditions (e.g., eczema, dermatitis, allergies, rash). Halobetasol reduces the swelling, itching, and redness that can occur in these types of conditions. This medication is a very strong (super-high potency) corticosteroid.
HOW TO USE: Use this medication on the skin only. Do not use it on the face, groin or underarms unless directed to do so by your doctor.Before applying the medication, clean and dry the affected area. Apply a thin film of the medication to the affected area and gently rub in, one to two times daily or as directed by your doctor. Do not wrap, cover or bandage the area unless directed to do so by your doctor. If used in the diaper area on an infant, do not use tight-fitting diapers or plastic pants.After applying the medication, wash your hands unless you are using this medication to treat the hands. If applying this medication near the eyes, avoid getting it in the eyes as this may worsen or cause glaucoma. Also avoid getting this medication in the nose or mouth.Use this medication only for the condition prescribed. Do not use it for longer than two weeks in a row unless directed to do so by your doctor.If your condition worsens or does not improve in 2 weeks, contact your doctor.
Quick GuideRingworm: Treatment, Pictures, Causes, and Symptoms
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Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.
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Your Future According To "Arrested Development"
I predict more "Arrested Development" humor in your future. Especially if you receive a reading with this prophetic Tarot deck. See what fate has in store for you according to the Bluths. Just keep your fingers crossed that you don't pull the death card. We all know how that worked out for Buster. [Buzzfeed]

subset: commoncrawl


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Happy Thanksgiving, Everyone
Yes, Thanksgiving (at least the one that occurs on the fourth Thursday in November) is an American holiday, we want to say Happy Thanksgiving to the rest of the world as well. Not to get all "We Are The World" on you, but maybe we should have a global day of Thanksgiving, so that we can all collectively celebrate together as humans.
But what do we know, we just review plastic gadgets.
Happy Thanksgiving, everyone!


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Suddenly, the review of the Fair Work Act is being extended to accommodate the political disaster of the
Until now, the idea that unions needed to be more closely scrutinised would have been rejected. At the ACTU Congress in mid-May, president
Fair Work Australia president Iain Ross has revealed that he has told the review panel, which is dominated by industrial relations club insiders, that legislative changes were needed to clarify the tribunal's role and independence. The most likely result of this will be recommendations along the lines suggested by Mr Ross of more clearly separating the governance of unions, where rule of law is supposed to apply, from the industrial relations function, where political fixes are the order of every day.
However, Mr Ross now has also slapped down vice-president
All of this contrasts with the refusal of Workplace Relations Minister
The reason for the different responses to changing the review's instructions is political. The government needs to deal with the Thomson fallout because its fate hangs on his vote. But it also needs to suppress the productivity debate as it conflicts with the interests of the labour monopolies that, as
It has always been this way. In 1911, the editor of the Hobart Mercury, the redoubtable H. R. Nicholls, famously accused the then president of the Commonwealth Court of Conciliation and Arbitration, Henry Higgins, of behaving in a politically partisan and unjudicial manner. One hundred years later, the industrial relations system is still politically tainted.
The Australian Financial Review


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ブラックスピーディ formula 1
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UNLV Performing Arts Center & Dept. of Music Welcome Three Times Four Feb. 20
The UNLV Performing Arts Center and UNLV department of music welcome Three Times Four — De Ann Letourneau, Las Vegas Philharmonic concertmaster; members of the UNLV faculty; and guest musicians — at 7:30 p.m. on Thursday, Feb. 20, in the Dr. Arturo Rando-Grillot Recital Hall as part of the UNLV Chamber Music Series.
The performance features piano trios and quartets by Haydn, Brahms, Turina, and UNLV's Diego Vega.
Tickets to Three Times Four are $25 and can be purchased in-person, on the phone or online through the Performing Arts Center Box Office, 895-ARTS (2787).
Student rush tickets are $10 each (not inclusive of the facilities fee), and available one hour prior to each event, based on availability and with valid student I.D. UNLV faculty and staff discounts also are available. A $1.50 facilities fee, in addition to the ticket price, is charged on all Performing Arts Center tickets.
The box office is open from 10 a.m. to 6 p.m. Monday through Friday and 10 a.m. to 4 p.m. on Saturday.
Information about all of the season's performances can be found on the Performing Arts Center website, located at pac.unlv.edu.
About the UNLV Performing Arts Center
Founded in 1976, the Performing Arts Center at UNLV is Southern Nevada's original performing arts venue, celebrating nearly 40 years of arts in Las Vegas. Located on the north end of the UNLV campus, the PAC hosts a variety of performances and is home to the Charles Vanda Master Series.
At the UNLV PAC, Southern Nevadans can enjoy the arts nearly every day of the year. The Performing Arts Center is home to productions presented by the Nevada Conservatory Theatre at UNLV and the UNLV music and dance departments, the Desert Chorale, and the Southern Nevada Musical Arts Society. The center also hosts more than 50,000 Clark County School District students yearly for productions, festivals, and concerts.


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Tuesday's baseball game between Utah and BYU at Miller Park was postponed due to inclement weather. The contest has been rescheduled for May 14.
Utah continues in Pac-12 play this weekend at Oregon State, with the three-game series beginning on Friday. The Cougars host a three-game series with Portland on Thursday.


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St. Paul's Episcopal Church is a downtown parish in the heart of Chattanooga, Tennessee. We are a diverse parish that actively celebrates the love of Jesus Christ within our parish walls and throughout the greater community. St. Paul's is home to a community where the best of Episcopal traditions embrace open-minded conversations; where beliefs are put into action; and each person is encouraged to seek God and progress on their own spiritual journey as we gather at the Lord's Table each service. The Church itself, an historical Chattanooga landmark, serves as a gathering place for worship, celebration, fellowship, outreach, solace, and learning. We welcome all persons, no matter their station in life. Whether you are visiting from another city or are seeking a spiritual home in Chattanooga; and whether you are a confirmed Episcopalian or new to the Episcopal Church, we invite you to explore our parish in person.
Our History
The founders of St. Paul's Episcopal Church first met in 1852 and held services on 2nd floor of Thomas McCallie's General Merchandise at 4th and Market Streets. In 1853 ten families met at home of Col. James A. Whiteside on Poplar Street to organize the parish. We currently hold services in our second Nave on Pine & 7th Streets in downtown Chattanooga, Tennessee. Built in 1881, our Nave is on the National Register of Historic Buildings.
Worship Times
8:00 a.m. Holy Eucharist Rite I: A traditional, spoken service with no music.
9:15 a.m. Christian Education and Formation for parishioners of all ages.
10:30 a.m. Holy Eucharist Rite II: A choral Eucharist service.
12:05 p.m. Monday through Friday every week. Join us for a brief service of the Holy Eucharist.


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Free Bins are located in all laundry rooms for clothing you no longer need. These bins are a clothing swap, so feel free to take items you can use. Please make sure you don't take other items in the laundry room, not in the bin, as they belong to hall residents.
At the end of the year, all left over clothing is donated to a local charity.


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Sales Discrepancies Lead Ticketmaster To Close Outlets
By NEIL STRAUSS
Published: June 1, 1995
The biggest complaint customers have about Ticketmaster, the national ticket distribution company, is not about ticket surcharges, long lines at outlets or busy signals on the phone. It is about ticket diversions. These take place at some outlets where tickets for choice seats, rather than being sold to customers, are set aside for scalpers (with kickbacks to the outlets) or for friends of outlet employees. Scalpers charge from $5 to $1,000 (for major concerts and sporting events) over the price of a ticket.
With no fanfare or publicity, Ticketmaster has recently closed 22 outlets and refused to renew the licenses of 11 around New York City in the last year. Of those, said a ticketing-industry insider who spoke only on condition of anonymity, 19 were suspected of diverting or mishandling tickets. This number amounts to more than one-tenth of Ticketmaster's 174 outlets in New York, Connecticut and New Jersey. Most recently, Bondy's Records in lower Manhattan was banned from selling tickets after Ticketmaster said it discovered a discrepancy between the tickets the outlet was taking off the central computer and the tickets that were actually being sold to the public. Bill Bondy, the owner of Bondy's, said he lost his contract with Ticketmaster in April for setting aside eight seats for his family members and employees for a Beastie Boys concert after first taking care of customers waiting in line for tickets.
One store owner, whose contract with Ticketmaster was not renewed, admitted having diverted tickets.
"There's dirty money in tickets for everybody, especially when you're an outlet only making about a quarter a ticket from Ticketmaster," said the store owner, who said he would speak only on condition of anonymity because he said he feared that he would violate a confidentiality agreement with Ticketmaster. "You sit there at your outlet and you wait until someone comes along, whether it's a broker or someone who sells tickets out of their house or someone who wants good seats for themselves to every show. And you just pull the good seats out of the system and set them aside for these people."
Ever since Pearl Jam filed a complaint with the Justice Department's antitrust division last year accusing Ticketmaster of exercising a monopoly over ticket sales in the United States -- a charge the company denies -- there has been a rash of negative press reports portraying Ticketmaster as a giant, greedy monolith. As Ticketmaster outlets are not operated by Ticketmaster employees but by independent retailers who have signed contracts with the company, it would seem to be in the company's best interest to publicize its efforts to stamp out ticket corruption rather than to veil its efforts in secrecy.
"These violations account for just a small portion of the more than 50 million tickets that Ticketmaster distributes every year," said Larry Solters, a spokesman for Ticketmaster. "As to why closures are not announced: the company's policy is not to discuss closures."
One reason might be that the outlets are not always permanently shut. This year, Ticketmaster closed an outlet at Video 237, a store in Island Park, L.I., for the second time, alleging that it was scalping tickets. But two weeks ago, the store obtained a court order dismissing Ticketmaster's claims and allowing it to reopen. Video 237 also has a lawsuit pending in Nassau County Court in Mineola, L.I., against Ticketmaster in which it is seeking more than $25 million in damages for the five weeks it was not allowed to distribute tickets.
Michael Schlussell, the lawyer for Video 237, said he believed that the outlet was shut down because Ticketmaster had personal differences with the store's owner. In the bigger picture, some outlet owners say they believe that Ticketmaster is trying to close mom-and-pop stores to consolidate and organize its outlets in and around New York. The 174 outlets in the metropolitan area are spread out among more than 50 businesses. By contrast, the 163 outlets in Los Angeles are contained within just three retail chains.
For Ticketmaster, there are advantages to moving its outlets into more established chains, said an owner of a small store with an outlet. Employees at chains are monitored more closely, affiliations with established retailers improve the standing of Ticketmaster in the public eye and many chains don't make special arrangements to open at 8 A.M. on days when tickets to big shows go on sale, thus diverting sales to Ticketmaster's telephone rooms, where service charges and profits are higher. Tickets to a Luther Vandross show at Jones Beach this July, at $35, were being sold through Ticketmaster outlets with a $5.25 service charge and over Ticketmaster phone lines with a $7.55 service charge.
Richard Schrader, a former New York City Department of Consumer Affairs Commissioner who is now a consumer lobbyist, has another theory about Ticketmaster's recent flurry of outlet closings. "I think this small improvement we're seeing was in response to investigations by the Consumer Affairs Department and the Attorney General, and the improvement was looking at the worst actors," he said.
"I also think the improvement is short term, and there needs to be an overhaul of Ticketmaster's investigative procedures. Brokers are getting these seats from somewhere, and one of these places is Ticketmaster outlets. There has to be some real structural change at Ticketmaster and a commitment to being more aggressive."


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North Korea blamed the South and the US for provoking its artillery bombardment and warned yesterday it was ready to strike again, as a US carrier headed for war games off the tense peninsula.
World powers agonised over how to deal with the volatile and nuclear-armed communist regime over its attack on a Yellow Sea island, in what one veteran North Korea watcher labelled a diplomatic "problem from hell".
Isolated North Korea charged in a statement that "the US can never evade responsibility for the recent exchange of fire", in which four people died when Pyongyang's forces shelled the island on Tuesday.
"If the warmongering South Korean puppets fail to return to their senses and commit another reckless military provocation, our army will carry out second and third rounds of powerful physical retaliatory strikes without hesitation."
The warning came as the US and South Korean navies planned to hold a four-day exercise in the Yellow Sea from Sunday that will involve a strike group headed by aircraft carrier the USS George Washington.
Although the show of allied maritime firepower had been scheduled well before this week's attacks, the US military said it would also demonstrate the US "commitment to regional stability through deterrence".
South Korea also said it would "sharply increase military forces, including ground troops, on the five islands in the Yellow Sea and allocate more of its budget towards dealing with North Korea's asymmetrical threats".
Enraged by the first shelling of its civilians since the 1950-53 Korean War, South Korea was still counting the cost of the attack on Yeonpyeong island.
The explosions that shattered the calm of the remote islet killed two Marines and two civilians, wounded 18 others and left 22 buildings in ruins.
Newspapers have called for revenge against the "mad dog" regime, protesters have burnt North Korea's flag, and some politicians have berated President
US President
The world has often been baffled by the regime ruling impoverished North Korea, which has staged two nuclear tests, fired missiles over Japan and this month showed off a modern new nuclear facility to a US academic.
The Australian Financial Review


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MOSCOW (AP) — British Prime Minister David Cameron insisted Monday that Russia and Britain can overcome the sharp differences in their relations — even the 2006 poisoning death of a Kremlin critic in London — to seal new trading ties and help promote world stability in the wake of the Arab uprisings.
Cameron was in Moscow for the first visit to Russia's capital by a British leader in six years, meeting with President Dmitry Medvedev, and holding the first talks by any British official with Prime Minister Vladimir Putin in more than four years.
Ties between Britain and Russia soured over the 2006 poisoning death of dissident ex-Russian security agent Alexander Litvinenko in London. Litvinenko made a deathbed statement accusing Putin of authorizing his killing.
Russia has refused British requests for the extradition of the chief suspect in the case, ex-KGB agent Andrei Lugovoi, who denies involvement.
Following talks at the Kremlin, Medvedev told Cameron there was no prospect of Lugovoi facing a British court because the Russian constitution prohibits the extradition of a Russian citizen.
"This will never happen, no matter what the circumstances," Medvedev said during a news conference with Cameron. "We all have to learn to respect our legal frameworks."
The two leaders also joked about what Cameron believes was a KGB attempt to recruit him during a 1985 trip to Russia when he was still a teenager.
"I'm sure that David would have been a very good KGB agent, but in that case he would never have become prime minister of Britain," Medvedev said at the news conference.
Cameron, who was to meet with Putin later in the day, said his visit would focus on developing new businesses opportunities.
Since taking office in May 2010, Cameron has looked to developing economies to help kick-start Britain's sluggish growth, leading large delegations of business executives on visits to India and China.
"I accept that Britain and Russia have had a difficult relationship for some time," Cameron told students Monday morning at Moscow State University. "We should be candid about the areas where we still disagree. But I want to make the case for a new approach based on cooperation."
Cameron was accompanied by about 20 business leaders, including oil company BP's chief executive Bob Dudley and Royal Dutch Shell CEO Peter Voser, and planned to seal new deals worth 215 million pounds ($340 million) — which would create 500 new jobs in Britain.
British companies are also likely to win new rights to bid for contracts on Russian-led civil nuclear projects, while Cameron's government will support Russia's efforts to join the World Trade Organization.
"Never believe that just because the relationship is difficult now, it can't be better in the future," Cameron said in response to a student's question. "There are many reasons for optimism and hope."
In an interview with Britain's Sky News television, Lugovoi urged Britain to focus on trade, and accept that demands for him to face trial were unlikely to be met.
"I am sure that this is the dream of Cameron — don't speak about me. It looks idiotic," Lugovoi said. "For the last four years, the first question from every British politician has been about me, despite the fact that Britain is the biggest investor in the Russian economy."
Cameron insisted the Litvinenko case was not being ignored amid the push for trade, and disclosed that Foreign Secretary William Hague had spoken to Litvinenko's widow Marina before he and the British leader traveled to Moscow.
"This issue hasn't been parked, the fact is that the two governments don't agree," Cameron said at the Kremlin news conference. "I don't think that means that we should freeze the entire relationship."
But Cameron warned that a major upgrade of trading ties would need Russia to make progress on reforming its criminal justice system.
Last month, BP complained that a Moscow office had been illegally raided after Russian bailiffs accompanied by armed policemen searched its premises in connection with a lawsuit.
Foreign businesses "need to know that they can go to a court confident that a contract will be enforced objectively and that their assets and premises won't be unlawfully taken away from them," Cameron said.
Hinting at the Litvinenko case, Cameron called on Russia to do more to ensure its courts were impartial.
"The accused has a right to a fair trial. The victim and their family have a right to justice," Cameron said in his speech. "There are extradition cases Russia wants to pursue, and we still disagree with you over the Litvinenko case."
Britain ended intelligence cooperation with Russia as a result of Litvinenko's killing. Cameron confirmed that it would not be restored, but said law enforcement officials may work more closely against organized crime. Cameron also claimed that Moscow and London could work together to tackle the threat of terrorism — and must continue to show unity on efforts to prevent Iran from developing nuclear weapons.
Cameron also urged Russia to work closely with Britain and other United Nations Security Council members to help ensure stability in the Middle East and North Africa.
Russia has so far refused to support efforts by Britain, the United States and France to pass a U.N. resolution authorizing sanctions against the regime of Syrian President Bashar Assad.
Hague said talks Monday would focus on efforts aimed at persuading Russia to support a tougher U.N. stance on Syria.
"The stability of corrupt and violently repressive dictatorships in Middle Eastern states like Gadhafi's in Libya is false stability," Cameron said.
"The transition to democracy may well have its difficulties and dangers, but it is the best long term path to peaceful progress and is a powerful alternative to the poisonous narrative of Islamist extremism," he said.
Dudley joined the trip following the collapse earlier this year of BP's planned Arctic oil deal with Russian state-owned energy company Rosneft — an agreement that had been seen as critical to BP's recovery from the Gulf of Mexico spill.
Rosneft last month agreed to a partnership with U.S. company Exxon Mobil to develop offshore oil fields in the Russian Arctic, one of the world's last regions with major untapped hydrocarbon deposits. In return, Rosneft has the option to acquire parts of oil projects in Texas and the Gulf of Mexico.


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RSS is a way to tell your favorite websites to let you know when they have new content. RSS also allows you to access this content on your own timetable. RSS does not clog up your email.
First, you pick an RSS Feed Reader. A couple of free and easy to use ones are Google Reader and Bloglines.
Second, when you see an RSS icon, click it. The page that comes up will give you everything you need to enable the content you want to come to you.
For a simple and quick video description of how RSS works, view the video at the bottom of this page.
Do not show me this again:
There is certainly enough stress in all of our lives these days. Unfortunately,
most people try to live with it until it shows up as headaches, sleeplessness or irritability. People who are under constant stress are more vulnerable to illness, everything from colds to high blood pressure and heart disease. One strategy to help our body rebound from excessive stress is to eat stress-fighting foods.
Foods can help fight stress in a variety of ways. Some foods can actually boost levels of serotonin, a calming brain chemical, while other foods can reduce levels of cortisol and adrenaline, stress hormones that can build up and take a toll on the body over time. Foods that strengthen the immune
system or lower blood pressure will naturally help your body overcome potential damage from stress.
Below are some recommendations from WebMD for stress-fighting foods:
• Complex Carbohydrates. All carbs prompt the brain to make more serotonin. It's best to eat complex carbs which are digested more slowly. Good choices include whole-grain breakfast cereals, breads, pastas, and oatmeal. Complex carbs can also help stabilize blood sugar levels.
• Oranges. Oranges offer a wealth of vitamin C. Studies suggest that vitamin C can reduce levels of stress hormones and strengthen the immune system.
• Spinach. The magnesium in spinach helps regulate cortisol levels that can get depleted when we're under pressure.
• Fatty Fish. Fatty fish like salmon and tuna contain omega-3 fatty acids, that can prevent surges in stress hormones and protect against heart disease. For greatest benefit, go for three ounces of fatty fish at least twice a week.
• Avocados. The potassium in avocados can help to reduce high blood pressure. It may surprise you to know that half an avocado has more potassium than a medium-sized banana.
• Herbal Supplements. Since there is no FDA regulation of herbal supplements, consumers must be especially cautious of exaggerated claims. One of the most studied herbal supplements is St. John's wort, which has shown benefit to people with mild-to-moderate depression. Although more research is needed, the herb also appears to help with anxiety and PMS.
• Bedtime Snack. While carbs at bedtime may help you sleep better, heavy meals before bed can trigger heartburn, so choose something light like toast and jam. Another bedtime stress reducer is something we remember from grandma, a glass of warm milk. Researchers have found calcium can reduce muscle spasms and ease tension. Most dietitians recommend skim or low-fat milk.
Source: WebMD.com. To learn about other stress-reducing foods, go to: www.webmd.com/diet/diet-for-stress-manage ment-slideshow


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Edgar Cayce (1877–1945) founded the non-profit Association for Research
and Enlightenment (A.R.E.) in 1931, to explore spirituality, holistic health,
intuition, dream interpretation, psychic development, reincarnation, and
ancient mysteries—all subjects that frequently came up in the more than 14,000
documented psychic readings given by Cayce.
Edgar Cayce's A.R.E. provides individuals from all walks of life and a variety of
religious backgrounds with tools for personal transformation and healing at all
levels—body, mind, and spirit.
A.R.E. Press has been publishing books since 1931 as well, with the mission of
furthering the work of A.R.E. by publishing books, DVDs, and CDs to support the
organization's goal of helping people to change their lives for the better physically,
mentally, and spiritually.
In 2009, A.R.E. Press launched its second imprint, 4th Dimension Press. While
A.R.E. Press features topics directly related to the work of Edgar Cayce and often
includes excerpts from the Cayce readings, 4th Dimension Press allows us to take
our publishing efforts further with like-minded and expansive explorations into
the mysteries and spirituality of our existence without direct reference to Cayce specific content.
A.R.E. Press/4th Dimension Press
215 67th Street
Virginia Beach, VA 23451
Tel: 757-428-3588
Fax: 757-491-0689
Cassie McQuagge
Production, Customer Service, Rights & Permissions
A.R.E. Press/4th Dimension Press
215 67th Street
Virginia Beach, VA 23451
Tel: 757-457-7239
Fax: 757-491-0689


text:
A certified Service Disabled Veteran and Minority Owned Small Business.
The Senior Application Developer provides a vision and technical guidance for the development of capabilities and enhancements of data services that support simulation training systems. The primary duties of the Senior Application Developer are to collaborate with the functional simulation managers to understand and capture their technical and data protocols and requirements. These requirements are analyzed and structured to provide a common application baseline and a data architecture that supports the service that provides data to simulations. The Senior Application Developer will be working with Oracle RDBMS (including spatial, partitioning and context services), RESTful Web Services and an ExtJS interface. The Developer should also have a background in agile system development which is utilized for roll out faster updates and improvements while providing a much more stable and reliable service environment.
The Senior Application Developer may also develop and/or collaborate with other team members to develop database schemas, process charts, functional block diagrams, and prepare test data to facilitate software design and implementation. The Senior Application Developer will also be responsible for the proper use of design, programming/implementation techniques and interfacing with customer technical experts and members of Loyola's development staff. The Senior Application Developer will develop documentation from software requirements and system specifications and work with other staff in a team environment. The Senior Application Developer may also be asked to assist in spatial application development.


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Tim Tebow has been oft-criticized for his delivery. But he doesn't seem to have any problem being on the money with Dr. Seuss.
The Denver quarterback is participating in BOOK IT!, a reading incentive program sponsored by Pizza Hut by reading Green Eggs and Ham.
In an interview, Tebow says it was one of his favorite books and helped him overcome some reading disabilities that he battled as a child.
The reading by Tebow is of course excellent but our favorite remains Rev. Jesse Jackson's performance on Saturday Night Live.
Thanks to Huffington Post for the video assist.
Reid Cherner has been with USA TODAY since 1982 and written Game On! since March 2008.
He has covered everything from high schools to horse racing to the college and the pros. The only thing he likes more than his own voice is the sound of readers telling him when he's right and wrong.
Michael Hiestand has covered sports media and marketing for USA TODAY, tackling the sports biz ranging from what's behind mega-events such as the Olympics and Super Bowl to the sometimes-hidden numbers behind the sports world's bottom line.


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Greeley students join statewide plea for better school funding
February 6, 2013
The Council of Student Representatives
» Greeley Central High School — Austin Bradfield, Katy Campbell, Patrick Ryan, Ivonne Morales
» Greeley West High School — Joel Knepper, Steve Marcantonio, Aaron Zimola
» Jefferson High School — Sam Conde, Omar Garcia, Jessica Hester
» Northridge High School — Olivia Cardenas, Amanda Cary, Jacquelyn English, Marlee Snyder
For more information on The Year of the Student click here
For the past three years, every time Linda Trimberger came back from a Colorado Association of School Boards conference, you knew immediately what the first thing on her agenda would be.
The student groups were so wonderful, she would tell the board, "we really need to have one."
The groups she was referring to were groups of students from across the state that reported directly to their respective school boards and helped keep them informed on things affecting students.
Trimberger asked for one every year, and finally, last year she got everyone to listen and the Council of Student Representatives was created. The inaugural students are in their first full year and are already making an impact on everyone they meet.
We want them to know this district is great already, but it could be so much greater if we had more money.
— Steve Marcantonio, Greeley West High School council member
Three or four students from each high school were chosen by their principals to represent the school based on their grades and ability to lead, so it's not surprising that when you get a group of them together, they can impress the best of them.
"We have seen firsthand a greater population in our schools that need extra resources," said Steve Marcantonio, a senior at Greeley West High School, of whether the district needed additional resources. "If we did have the money, I trust this school board to spend it on those items."
A Greeley Central representative, junior Patrick Ryan, said he never doubted officials when they said this district was one of the worst funded, but when he got involved with the CSR and got an inside look at things, it really drove the message home.
"It didn't shock me," he said. "Being a student, people tell you all the time you can't afford something. But this really put it into perspective where we are compared to other districts."
The students recently presented their first major project, "The Year of the Student," to the school board at a regular meeting. The project is part of a statewide initiative that asks the Colorado Legislature to address Colorado's poor funding mechanism for K-12 and higher education.
"We just kind of hopped on the bandwagon," Steve said with a laugh.
On Jan. 30, the group along with several dozen other student groups presented their message to the Legislature and governor via a petition that said lack of funding can't be business as usual this session. The petition was signed by more than 8,000 people from across the state.
The experiences that this opportunity gives to students are some they will never forget.
"This really broadened my horizons in understanding the challenges the district truly does face," said Jacquelyn English, a sophomore at Northridge. "It has also allowed me a closer relationship with Trimberger and (Superintendent) Dr. Lang."
The students said when they first learned about CSR they were excited to get on board because they want to help their district get better.
"I really like the opportunity to be a part of something bigger than myself," said Amanda Cary, a Northridge junior. "I wanted to have a broader role in my school."
Northridge Principal Wes Paxton sponsors the group. He said when he first learned about the idea he was excited to help out anyway he could.
"Working with students in District 6, you see they want a voice," he said. "You see they want to change the community for the better. They want to bring students together to give them choices and to make a difference."
Aaron Zimola, a junior at West, said getting students to sign the petition at his school was pretty easy. He said he and Steve used the same line on everyone.
"See that roof three feet above you that's about to fall? If it falls on you, it will give you cancer," the two said with a cautious laugh about the condition of West and the asbestos it holds in its rafters.
"We want them to know this district is great already, but it could be so much greater if we had more money," Steve said.
"We have one of the highest percentages of poverty, but one of the lowest budgets," Aaron added. "And we are the future."
Marlee Snyder, a junior at Northridge, said they all know it takes a lot to change policy but they just wanted the legislature to hear them out.
"If they think about it, it means more coming from us," Marlee said. "Because we're the kids that see it everyday."
The students will now begin to work on their next big projects which include hosting a leadership conference for eighth-graders in the district and a walk to educate the community about the schools and what they mean.
"They are hoping if people will walk with them they will realize that this district has good students, good teachers and good administrators," Paxton said. "And that they are doing good things and care about these kids."
Trimberger said this was exactly what she hoped for when she envisioned this type of student engagement.
"It has been an honor to work with this group of students," she said during the board meeting on Jan. 28 when the students presented their project. "They really are the future and probably will be sitting in these chairs some day. They are a great group of students."
Sherrie Peif covers education for The Tribune. Her column runs on Mondays. If you have an idea for a feature, contact Sherrie at (970) 392-5632 or by email at firstname.lastname@example.com.
The Council of Student Representatives
» Greeley Central High School — Austin Bradfield, Katy Campbell, Patrick Ryan, Ivonne Morales
» Greeley West High School — Joel Knepper, Steve Marcantonio, Aaron Zimola
» Jefferson High School — Sam Conde, Omar Garcia, Jessica Hester
» Northridge High School — Olivia Cardenas, Amanda Cary, Jacquelyn English, Marlee Snyder
For more information on The Year of the Student click here
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Interactome Databases
Human Interactome
Virus-Host Interactome
Plant Interactome
Worm FragmentomeDB
Worm Interactome
Yeast Interactome
ORFeome Databases
Human ORFeome
Worm ORFeome
ORFeome Collaboration
CCSB Doc Depot
Network science deals with biological complexity by summarizing complex systems as components (nodes) and interactions (edges) between them. Despite or even perhaps because of such simplifications, informative discoveries can and have been made (Interactome networks and human disease, Cell 2011). In cellular systems nodes are metabolites and macromolecules such as proteins, RNA molecules and gene sequences, while the edges are physical, biochemical and functional interactions that can be identified with a plethora of technologies.
The first step is to provide maps of such functional interactions using systematic and standardized approaches and assays that are as unbiased as possible, undertaken by the Interactome Group. The challenge then faced by the Network Biology Group is to examine the resulting ''interactome'' networks, the networks of interactions between cellular components, and extract global or local graph theory properties. Such graph properties can be related back to improved understanding of biological processes.
Network Perturbations
The Network Biology Group has been exploring how perturbations of interactome networks may differ between complete loss of gene products (node removal) versus interaction-specific or edge-specific (edgetic) alterations (Edgetic perturbation models of human inherited disorders, Mol Syst Biol 2009; 'Edgetic' perturbation of a C. elegans BCL2 ortholog, Nat Methods 2009), and how protein-protein interactions are mediated through independently folding modular domains (A protein domain-based interactome network for C. elegans early embryogenesis, Cell 2008). A novel network modeling strategy was applied to successfully identify genes potentially associated with higher risk of breast cancer (Network modeling links breast cancer susceptibility and centrosome dysfunction, Nat Genet 2007).
Efforts are now underway to carry out edgetic profiling systematically for dozens of diseases, hundreds of proteins, and thousands of genetic variants. This undertaking is supported by a Center of Excellence in Genomic Science (CEGS) award on "Genomic Analysis of Network Perturbations in Human Disease" grant P50-HG004233.
Disease Networks
Creation of networks of genetic disorders and all their known gene associations (The human disease network, PNAS 2007), or of drugs and all their known protein targets (Drug-target network, Nat Biotechnol 2007), enabled worthwhile insights into human disease and disease therapy. Protein-protein interaction mapping efforts focused on specific human diseases (ataxia [Lim et al, Cell 2006; Lim et al, Nature 2008], autism [Sakai et al, Sci Trans Med 2011], and breast cancer [Pujana et al, Nat Genet 2007]) have identified novel interactions among proteins encoded by known disease genes, and have also predicted new disease susceptibility genes. The common finding among these disease interactomes is the discovery of unexpected relationships between disease genes that initially appeared unrelated [e.g., Kahle et al, Hum Mol Genet 2011 for ataxia]. Building and analyzing more disease-centric networks is accordingly a critical step towards deeper understanding of underlying disease mechanisms. Such efforts are currently supported by NIH grant R01-GM109199 "Functional profiling of human disease targets".
Network Evolution
As networks expand and rewire, new nodes, that is new genes and new proteins, get joined into the network. A longstanding question in evolution is where do new genes come from. We formalized for the yeast S. cerevisiae an evolutionary model by which functional genes evolve through transitory proto-genes generated by widespread translational activity in non-genic sequences (Proto-genes and de novo gene birth, Nature 2012). Proto-genes mirror for gene birth the established pseudo-gene route to gene death (Figure).
Edgetic perturbations might play a role in evolution. In the first proteome-wide binary protein-protein interaction map for the interactome network of the reference plant Arabidopsis thaliana we observed a dynamic rewiring of interactions following gene duplication events. The interactions mediated by the products of duplicated genes diverged in a time-dependent manner similar to how their protein sequences diverge. This finding argues that rewiring of protein-protein interactions of proteins encoded by duplicated genes contributes strongly to phenotypic evolution (Arabidopsis Interactome Mapping Consortium, Science 2011).
Current Efforts
The Network Biology Group efforts are focused on deciphering properties and meaning of the recent concluded Space-II map of the human interactome (here). Another major effort is the interpretation of an unprecedented and robust inter-interactome network map constructed by confronting together two proteomes, yeast Saccharomyces cerevisiae and human, evolutionarily separated for a billion years.