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Hello I was prescribed accutane at 20mg a day. I had bad side effects and was generally very scared. I stopped and now considering trying 20mg every three days? Haven't had the chance to talk to my derm yet but would like some other opinions. My acne is mild but flares up occasionally. I have blackheads that won't go away. Would love clear skin but can't handle the side effects being so prominent - I can literally feel my body reacting badly, i had a lot of pain when I moved. Thanks!
Accutane: 20mg Twice a Week As Opposed to 20mg a Day?
Doctor Answers 1
20mg dosage of Accutane a few times a week
There are many patients whom I put on a low dosage like this for long-term maintenance, but usually after they've already undergone a regular course. It's important to understand that the purpose of taking Accutane is to get a minimum mg of the medication into your system to combat your weight and the type/severity/location of your acne. Taking it a few times a week will definitely help your skin, but your improvement will take quite a bit longer than taking it daily because you won't be getting the mg into your system as quickly. As long as you and your derm are ok with that, it's a fine way to proceed.
These answers are for educational purposes and should not be relied upon as a substitute for medical advice you may receive from your physician. If you have a medical emergency, please call 911. These answers do not constitute or initiate a patient/doctor relationship.


text: those are the ones i see here in london. those arent the books in question. mina and ambrosi carry some that are bright orange. they may also feature a crude depiction of mt vesuvius inside the cover that one is caccioppoli not loro piana they have fabrics made for them by others eg lp

subset: commoncrawl


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Jaya Mishra
Sometimes - Poem by Jaya Mishra
Sometimes you feel that your presence isnt very much affecting the people around you.
Sometimes you feel left-out, you feel lost.
Sometimes you want to speak your heart out but could see no one around.
Sometimes you desperately wait for someone to knock at your door but could hear not even some hush.
Sometimes you find yourself biting your dinner alone.
Sometimes you crave for a good night kiss.
Sometimes the blanket cannot even calm your shivers.
Sometimes no one look at your eyes.
Sometimes you act stupid, intentionally, to grab attention but find no reactions.
Sometimes you lie at the corner with your ear plugs plunged in your ears and remain unnoticed.
Sometimes you just stare at the rose drying in the corner of your room.
Sometimes you cannot sleep with lights off.
Sometimes you wake up on a wet pillow.
Sometimes you sit wondering what went wrong and neither have anyone to explain.
Sometimes you call the dearest and get no response....
Comments about Sometimes by Jaya Mishra
Kishor Pathak (1/4/2013 2:22:00 PM)
Beautiful write...Could have been better if lines would have been short and fragmented... (Report) Reply
Kanav Justa (12/8/2012 11:03:00 AM)
Sahil Sood (11/28/2012 10:02:00 PM)
just so true, emotional and natural.. happens wit everyone..
luvd this poem.. (Report) Reply
Shihabudheen K J (11/28/2012 1:25:00 PM)
Just true words.very emotional rather gracing the poetry elements well (Report) Reply
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Jaya Mishra's Other Poems
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Caged Bird
Maya Angelou
Rudyard Kipling
Stopping By Woods On A Snowy Evening
Robert Frost
A Dream Within A Dream
Edgar Allan Poe


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When I opened my freezer for the first time after the trip, I knew that I need to make an effort to clean it up. I have frozen berries from red/white currants, black currant, raspberries, strawberries, blackberries, blueberries, yellow raspberries, you name it, it is crazy. I had some white chocolate mousse that I have put in a mold and ready to be used up in a cake, everything is in there. Now that Summer is getting really close, I definitely need to clean that up before stocking up again for the next winter time.
Since I haven't gotten around to download the new cake pictures from the camera yet, I will start by posting the one I made from last year before I left on my trip, in no particular order (I have A LOT).
As you've probably know, I am a big fan of Pierre Herme's lemon cream and I had been thinking of making the passion fruit version of that. Passion fruit is probably my favorite tropical fruit (same level as mango), something about the bright taste just reminds me of sun in tropical paradise. Anyways, so I was trying to use up some of the ingredients in my freezer (which I still need to do) before I left for months, and I found tart dough sitting in the back of my freezer. I thought this was perfect to make the passion fruit tart I've been wanting to make.
Evan, tried in her blog and she made it as beautiful as the book does. The recipe for the passion fruit cream is similar, both has huge amount of butter that you blend at the end. It is not really surprising since Pierre used to work at Laduree before opening his own shop, so you would find similar desserts between the two. I decided to go with Pierre's version by adding thin genoise and raspberry jam layer in the middle. I didn't use his genoise recipe though, I used some joconde I had available at that time and I made simple raspberry jelly.
|Pierre Herme Sampler
|Sadaharu Aoki's lemon tart with white chocolate cream and fresh strawberries (BF's favorite!)
|Sakura and Green Tea Eclair at Aoki's
|Toshi Yoroizuka's patisserie, I had the sakura white chocolate mousse (not pictured here)
It was an amazing week we had in Japan.I finally got to cross off one item in my bucket list, which is visiting Japan during the cherry blossom season, and let me tell you, it was AMAZING! Japan is amazing, from the people, the food (oh the food was definitely memorable), the culture, everything was great, except the fact that it is also expensive. Will definitely go back there one of these days.
|Raspberry and Rose Religieuse
|Fraise (strawberry buttercream, joconde, strawberr garniture)
|Laduree Boutique
Passion Fruit and Raspberry Tart
adapted from Pierre Herme
Pate Sucree
yield: three 101/2-in crusts or four 8-in crusts
300g unsalted butter, cubed, at room temperature
190g powdered sugar
60g ground almonds
1 vanilla bean, scrapped
2 eggs, room temperature
500g all-purpose flour
1 tsp salt
* Put the butter in a mixer bowl and cream until smooth and creamy using a paddle attachment.
* Add the sugar, ground almonds, and vanilla bean seeds. Mix until combined.
* Add the eggs one at a time, fully incorporating the previous one before adding the next one (the dough might look curdled at this point but don't worry, it'll come together once you add the flour)
* Combine the flour and salt. Add to the dough in about three addition. Mix until just it comes together. Do not overwork! Like Pierre said, "it's better to have lumps of butter rather than to have an overworked dough".
* Divide the dough in the portions you need. Form each one into a ball and flatten it into a disk. Wrap each disk with plastic wrap and store in the fridge overnight (you can also freeze the dough at this point and thaw it in the fridge overnight).
* Remove one disk from the fridge, and roll it either between two sheets of parchment paper, or just well-floured surface. You need to move quickly though. You don't want the dough to be soft and overworked.
* Line your tart pan with the dough and put it back in the fridge for at least 1-2 hrs to rest.
* Preheat the oven to 350 F.
* When you're ready to bake, put a parchment paper on top of the dough and fill the bottom with either rice or beans.
* Bake for 20 minutes. Take the parchment paper and the beans/rice off, then continue to bake for another 5-10 minutes until it's golden brown.
* Let cool in the ring.
Passion Fruit Cream
200g whole eggs
180g granulated sugar
150g passion fruit pulp (no seeds)
15g lemon juice
300g unsalted butter, at room temperature
Mix the eggs, sugar, passion fruit pulp, and lemon juice and cook in a bain-marie, making sure that the bottom of the bowl doesnt touch the hot water underneath. Stir/whisk constantly until the mixture thickens and reach 85-86C. Strain the mixture and let cool to about 55-60 C and put it in a blender (if you don't have a hand-held blender). Add the butter a couple of pieces at a time, to make an emulsion. The mixture will lighten in color. Continue running the blender for a few minutes after all of the butter has been added to ensure the airy and light cream. Make sure stop and run the blender a few times to avoid over-heating.
Joconde - or use any thing sponge
Raspberry jelly - you might want to quarter the recipe depending on how many tarts you're making
Passion Fruit Glaze
neutral glaze (see below)
passion fruit juice (with pulp)
Translucent Glaze
250 ml water
Orange zest
Lemon zest
1 used vanilla pods or ½ vanilla bean seeds
100 g sugar
10 g pectin NH (15g for regular pectin)
10 g lemon juice
3-4 chopped mint leaves


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Style Buzz: Lolita Storms Spring Fashion And "Juicy" Gisele Rumors
- Move over cougars, 2010 is all about the Lolita look. [Style.com]
- When it comes to spring hairstyles, it's celebrities versus models! You can't not look. [Elle]
- All the fashion rules that are fit to break this year. We suspect we've already broken them all this month. [Shine]
- Michelle Obama's fave designer Jason Wu is pulling a Gaga and launching a new camera line. It's the hottest new collaboration trend! [Stylelist]
- Is Gisele retiring? Let's see, she has a new baby, gorge husband and more cash than she could spend in a lifetime, so she's still got that going for her. [Fashionologie]


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Sloe Gin
A Crimson-Colored Gin and Punch for Fall
In addition to improving the overall quality of the mixed drinks we consume, the craft cocktail movement has opened the American market not only to the storied classic cocktails of old, but also to once-thriving product categories. One such subdivision...
Spirit Works Distillery
by Heather Stewart Feldman In Sonoma County wine country, Spirit Works Distillery is laboring over something quite different to sip on. Dreaming of working with their hands, making a product that was authentic and sustainable, husband and wife team...


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VILLAGERS have claimed victory in a four-year battle to remove temporary buildings from Green Belt land after council workers moved in at dawn to tow them away.
Delighted campaigners woke yesterday morning to find district council workers had entered the Old Foresters sports ground, in Abridge Road, Theydon Bois, and begun demolishing the portable cabin and brick electricity storage building that have plagued them since they were built without planning permission in May 2008.
Members of Theydon Bois Action Group have been fighting to remove the 'eyesore' buildings since they were erected by landowners Parkeng and have repeatedly criticised the council for not doing enough.
Group chairman David McKelvey, 50, said: "Basically it's what we have been asking for for an awfully long time and we are just glad that the council have removed them.
"The developers have used every single trick in the book to not removing the buildings."
The district council issued Parkeng with an enforcement notice shortly after the buildings appeared – but the company and developer James Harris ignored the demand.
The authority took the firm to court last year, where they were fined £1,385 for not taking the buildings down and - after further attempts to negotiate with the owners failed - the council authorised the removal of the buildings in August.
"We have not just had the structures, we have had the Olympic campsite. It's been one thing after another. They have been getting away with murder," said Mr McKelvey.
"This could be a first step in stopping Green Belt land being built on."
He added: "It's a victory, but not the end of our fight. It's the first battle."
Frank Sparks, who lives opposite the site, said he and his neighbours were overjoyed to see the buildings removed.
"They were just an eyesore and they shouldn't have been there in the first place," said the 68-year-old.
"They defied an order – it's high time they went."
The site has now been entirely cleared and the buildings moved to the council contractor's yard, from where Parkeng has three days to collect them before they are scrapped.
Cllr Richard Bassett, cabinet member for planning, said: "This type of action is very much a last resort.
"The landowner has had plenty of opportunity to remove these illegal buildings but has chosen not to do so.
"It was therefore necessary for the council to make sure that that the law is upheld."
The Guardian has attempted to contact James Harris and is awaiting a response.
Click here to follow the Epping Forest Guardian on Facebook


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My Interview With Maria Brink of In This Moment
The band In This Moment is blowing up all over rock radio nationwide thanks to the song 'Blood' which is the title track from the band's 4th album which dropped on August 14th. A couple of days ago I got a chance to talk to lead singer Maria Brink for this weekend's edition of "Loudwire Radio". As always I want to make sure you, the 103GBF listener gets to hear it first.
Also, if you haven't seen the bizzare video for "Blood" I posted it as well.
Subscribe to WGBF-FM on


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[New Home Page]
"Loosely" based on the hit ABC television program of a similar name, Who Wants to be an Engineer is a fun way of exposing K-12 students to engineering.
Got a group of students coming to campus and need something to do with them? Have an exuberant student willing to interact with said students? This game may be your answer! The intent is to help students recognize that they already know some of the general science, math, and engineering facts that they will need to become an engineer.
Exit surveys of participants indicate students leave the activity with a more positive impression of engineering and are more likely to consider engineering as a profession. Of course, we asked this question of kindergartners, so the exact question was a bit different.
Students have the opportunity to answer three questions of increasing difficulty, all keyed to their grade level (elementary, junior high, and high school). Correct answers win prizes (as simple as pencils all the way up to t-shirts or even better). Incorrect answers have less fortunate consequences.
The game automates the visualization and prize tracking. A student is required to host the game, another to run the PC, a third to manage contestant selection, and a fourth to assist in prize distribution.
The question database is easily modified to suit your specific needs.
System Requirements: Windows PC, 128MB RAM, enough hard drive space, a video card, a keyboard, and a few other commonly found components. The game has been used successfully under Windows 98, ME, 2000, and XP.
No warranty is expressed or implied. The program may not be modified. You are granted a license to use the program for outreach activities on behalf on engineering in exchange for a copy of the database file containing any added questions. Use at your own risk. May not be used for profit. Sounds embedded in the program may be copyrighted by others, hence the mute function.
You will no doubt have many questions about the database file and program operation. Feel free to email me with questions. The more questions I get, the more likely I am to produce complete documentation. The basics of running the program are in the PowerPoint file in the Downloads section, along with notes on formatting the database file (requires MS Access).
Please email me if you download the program.
WWTBE Database formatting
(PDF, 12K) This will help with formatting of the database of questions to
customize the question set.
WWTBE Flowchart (PPT, 67k) This explains the actual operation of the game, which is intended to minimize errors during the show
WWTBE Install package (ZIP, 13MB) Everything you need to install the game on your own PC.
Who Wants to be an Engineer? A paper presented at the 2003 ASEE Annual Meeting on the use of the software in outreach


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'Just now I held up the fingers of my hand to you. You saw five fingers. Do you remember that?'
O'Brien held up the fingers of his left hand, with the thumb concealed.
'There are five fingers there. Do you see five fingers?'
And he did see them, for a fleeting instant, before the scenery of his mind changed. He saw five fingers, and there was no deformity.
(George Orwell, Nineteen Eighty-Four[1])
Evidence is beginning to filter through that detail the consequences of legislating for homosexual 'marriage' across nations and states. In an important submission to the UK House of Commons Public Bill Committee on the Marriage (Same Sex Couples) Bill 2012-13, researcher Patricia Morgan reviewed data from countries that had, to the time of publication on 1 March 2013, redefined marriage in their countries.[2]
The focus of her paper is to evaluate the claims "that opening up marriage to same-sex couples will actually strengthen the institution... (and) that same-sex marriage will thus serve the common good as well as promoting equality."[3]
Contrary to current propaganda, the findings depict a very negative picture. For example, contrary to the mantra that homosexual 'marriage' does not affect your marriage, she finds that "opposite sex relationships have to conform to gay norms, rather than vice versa, since matters pertaining to complementary sexes cannot apply to those of the same sex." For example, in Spain, birth certificates use the terms "progenitor A" and "progenitor B" in place of mother and father. Canada has removed the concept of "natural parent" from its laws and Sweden seeks to remove the terms "boy" and "girl", replacing them with one term.[4]
Marriage must be abolished and replaced with another concept, hostile to the first. This must be, as homosexual 'marriage' cannot exist under current law without first having the need to change terminology, or introduce something novel. Everybody's marriage must be redefined to accommodate the new order, and the new order is hostile to the former, having seen the need to demonise it as bigoted, hateful and exclusionary. The test is asserting the true nature of marriage under the new regime. Evidence of consequences of this steadily stream in. Three examples follow.
In New Zealand, following the legalising of homosexual 'marriage', the Government's Charities Commission declared its intent to deregister the Family First NZ organisation – this is not a political party, as in Australia. The group's leader, Bob McCoskrie stated that the Commission said that his organisation has "no 'public benefit', and that it is in the 'public interest' for Family First to be deregistered,"[5] because of its defense of marriage in opposition to the push for homosexual 'marriage'.
In the United States Air Force, Senior Master Sergeant Phillip Monk
filed a discrimination complaint with the U.S. military claiming he was fired by his lesbian commander for refusing to make a statement of support for same-sex "marriage" (and) may now face prosecution for taking his accusations public.
(He) was relieved of his duties as first sergeant at Lackland Air Force Base in San Antonio in August after two separate confrontations with an openly homosexual superior officer, Major Elisa Valenzeula.[6]
In one of many examples where small business owners in businesses linked to the wedding industry face prosecution for saying no to the new order, a Colorado baker is facing a year in gaol for not baking a 'wedding' cake for a homosexual 'marriage'. This is despite Colorado upholding marriage in its state Constitution![7]
In an important section of the study, Patricia Morgan examines the question "What has happened to heterosexual marriage rates where gays marry?" As background she describes how
Declining marriage rates, paralleled by increasing rates of unmarried cohabitation and births are generally seen as parts of a second demographic transition in the Western world, where marriage and family have been weakened as the primary child rearing environment.[8]
Nordic countries typify this trend, having out of wedlock birth rates above 50%. This is a tragedy with unfortunate sociological effects on children, undermining their need for a stable, supportive household underpinned by the marriage of their mother and father. Morgan examines Sweden, Norway, Denmark and Belgium, and observes how marriage rates were plummeting to begin with, prior to the changing of their marriage laws, and that high percentages of children were being born out of wedlock. Sweden and Norway serve as primary examples. Sweden, through various government 'initiatives' and policy decisions, degraded the status of marriage. This included a redefinition of marriage as "a form of voluntary cohabitation between independent persons". Morgan observed that "anything which might benefit it over cohabitation was stripped away as couples living together acquired much the same rights as married people."[9] It is not difficult to see where this was heading.
Other factors played a role in the decline of marriage in Sweden.
Divorce was made available on request without giving reason(s)… The withdrawal of support for two parent families, imposition of penalties on non-working 'partners' and very high taxation made it impossible to live on one wage. The word 'custodian' has designated the person closest to a child, who serves the state as the supervisor and agency on whose behalf parents act.[10]
In conjunction with the state's degradation of marriage was the corresponding rise in state involvement in the ordering of Swedish society.
Hence, by the beginning of the Twenty first Century, 55% of Swedish children were born out of wedlock. Should this be a surprise? Into this climate arrived homosexual 'marriage' in 2009. With its onset came the claim that it would rescue marriage, but this has not materialised. Morgan cites the country's divorce rates, which have soared since 2005[11], and during which period Sweden moved from civil partnerships to homosexual 'marriage'.
Norway's experience is much the same, where "between 1990 and 2000, Norway's out-of-wedlock birthrate rose from 39% to 50%."[12] The divorce rate per thousand inhabitants is 54.1 for Sweden and 54.8 for Norway. There is no evidence of any improvement in there figures following the legalisation of homosexual 'marriage' in these circumstances, but instead has served as the coup de grace of earlier trends.
Morgan moves to examine the fate of marriage, following the introduction of homosexual 'marriage', in more "traditionally family centred societies"[13] using the examples of The Netherlands and Spain. The introductory comment is that "the picture is bleak"[14] and it is not difficult to see why.
In The Netherlands, since the early 1990's, marriage rates have been declining. Divorce is increasing, as is the number of children born out of wedlock. The increasing levels of divorce have been aided by registered partnerships for heterosexual couples, which came in the same year as homosexual 'marriage', from 2001. The new order of 'marriage' could be converted to registered partnerships
which could be annulled without a court order. Using this process of 'flash divorce', some 30,000 couples separated in this way up to 2009; almost completely compensating for the decrease in formal divorces. At the same time, rights of married couples and registered partners were extended to unregistered cohabiters.[15]
The new order of 'marriage' had the direct result of an overall fall in marriage rates in the last ten years "dropping quite steeply from 88,000 plus in 2000, [to where] marriage is at its lowest since WWII (with 70,000 plus in 2010)."[16]
In 1980, the percentage of children born to unwed mothers was 4.1%. In 2000 it had risen to 24.9% and in the decade after homosexual 'marriage' had been introduced it rose again to 43.3% in 2009. The rise had increased by twofold in the last ten years, in contrast to the identical percentage rise level occurring over the prior thirty.
Spain saw marriage rates plummet after the introduction of homosexual marriage in 2005.
The annual number of marriages fell by over 14,600 over the first three years (2005-2007) in which same sex couples were able to marry. For the next three years (2008-10), the annual fall was 34,000.[17]
Again, as in other countries where homosexual 'marriage' has been introduced, divorce laws were liberalised in Spain.
The legal change eliminated the need for couples to be physically separated for a period before legal proceedings could begin. In the following year (2006), 126,952 divorces were registered in 2006, a 74.3% increase on the previous year. The sharpest rise was seen in divorces between those who had been married for less than a year: up 330.6%.[18]
This last and highly alarming figure indicates that services to assist newlyweds through their first year of marriage are necessary, to manage the whole shift of life away from the self and towards the spouse.
From the data Morgan has sifted, she draws the following conclusions:
What does same sex marriage do to marriage?
38. Same sex marriage is both an effect and a cause of the evisceration of marriage - especially the separation between this and parenthood. As rising out-of-wedlock births and cohabitation rates - as well as legal changes - disassociate marriage from parenthood, same sex marriage becomes conceivable. If marriage is only about couple relationships, and is not intrinsically connected to parenthood, why not give the leavings to homosexuals? As marriage is redefined to accommodate same-sex couples, this reinforces the irrelevance of marriage to parenthood. Elsewhere, same sex marriage is an instigator for the casualisation of heterosexual unions and separation of marriage and parenthood.
39. In the feedback loop, either:
'Gay' marriage is the end game of long running anti-marriage and family policy - typified by Sweden. Cohabitation and out-of-wedlock birth rates were rising and marriage rates were falling in Scandinavia long before the enactment of homosexual partnership/marriage laws. These trends are explicable in terms of the removal or reduction of incentives to marry by forces hostile to traditional conjugality. Same sex partnership/marriage then locks in and reinforces existing trends toward the separation of marriage and parenthood.
Gay marriage initiates the severance and dismemberment of marriage and family in more family friendly societies, such as Spain and the Netherlands. There is free-fall towards the Scandinavian model – driving "home the message that marriage itself is outdated, and that virtually any 'family form', is acceptable." Either which way, same sex marriage is more a terminus for marriage or ultimate act of dissolution, rather than a force for revival.[19]
A key reason for the failure of marriage in these nations can be clearly inferred. Once you redefine marriage to enact homosexual 'marriage', you destroy the intrinsic child oriented purpose of marriage and replace it with the satisfaction of adult preferences. In short, marriage loses its purpose, it becomes anchorless and adrift – its meaning has disappeared and is replaced by something alien to the rights of a child to be raised, where possible, by a mother and a father, and everybody's marriage is redefined. There should be no surprise that a collapse in marriage per se should follow. To assume the absence of serious consequences as a result of tampering with marriage is sheer folly, as is declaring it has "no public benefit"! There is hope for the countries mentioned above. They must reverse their abolition of marriage by removing homosexual 'marriage' from their statue books and concurrently promoting policies for strengthening marriage.
One unremarked upon factor in this attempt to redefine marriage is that children who develop same-sex attractions and later identify as gay or lesbian, also have the right to a mother and a father in law and society removed from them as well by homosexual 'marriage'. The irony is supreme. While a certain percentage of same-sex attracted men and women – not all – clamour for the non-existent right to marriage between members of the same sex, they strip the central right of every person to a mother and a father for all. Parents of the same, who lobby for marriage redefinition, declare their own motherhood or fatherhood irrelevant, which they feel drawn by to support what they see to be the interests of their children. To support the idea that two men can marry renders wives and motherhood irrelevant, as does the support for the idea that two women can marry have the same consequence for husbands and fatherhood. Surely this is evident? It also affects everybody and gives some indication of the profound rational dislocation such a policy causes.
All families should be spared from scenarios such as this from Minnesota, a microcosm of what happens when marriage is redefined to legislate for homosexual 'marriage', which redefined its marriage laws earlier this year:
I am the mother of a ten-year-old girl, a beautiful child, more precious to me than anything you can imagine. When, on June 1, same-sex marriage became legal in the state of Minnesota, I needed to know what to tell her. How is this supposed to work—actually—in the concrete world of a ten-year-old child and her mother? Her father is wondering too, of course, but he is rather speechless at the moment. And the way it works in our house, though he is really good at protecting her from possible physical threats, it usually falls to me to protect her from the more psychological threats she encounters occasionally in her young life. But this is a new one. So I need some advice…
With her child's natural grasp of real things, she already knows that married people have babies, and she knows it has something to do with mothers and fathers. But since our state has declared that the categories of mother and father are no longer relevant for marriage, that marriage has nothing really to do with children, how shall I explain to her where babies come from? She already knows that little people like her would not even exist in a world where same-sex marriage was the norm. Do I get to make any claims about the fact that only a mommy and a daddy can actually produce one?...
Oh, and will I now be required by law to sit silently when, a few years from now, I find her school has introduced a module into her sex education class on how homosexual persons go about having sex? Any suggestions on how I should help her with her homework for that class?[20]
The lessons for Australia are clear. First, empirical evidence of the destructive nature and effects of homosexual 'marriage' is being produced already. Second, while some countries rushed to change their marriage laws, Australia shows great wisdom and clear-eyed sobriety in not following suit - and should never follow suit. Last, policies need to be considered and implemented that strengthen marriage in Australia. Morgan's figure from Spain concerning the stratospheric rise in divorces after one year of marriage should be cause for reflection here. Work also needs to continue in collating sociological data from nations and states that have legalised homosexual 'marriage' and to report regularly on trends.
Australia needs to take careful note of the findings in Professor Patrick Parkinson's 2011 report For Kids' Sake:
The overwhelming evidence from research is that children do best in two-parent married families. As American scholar Prof. Susan Brown recently stated in a review of the research evidence:
"Over the past decade, evidence on the benefits of marriage for the well-being of children has continued to mount. Children residing in two-biological-parent married families tend to enjoy better outcomes than do their counterparts raised in other family forms. The differential is modest but consistent and persists across several domains of well-being. Children living with two biological married parents experience better educational, social, cognitive, and behavioral outcomes than do other children, on average. Variation in well-being among children living outside of two-biological-parent married families (e.g., married step, cohabiting, and single-parent families) is comparatively low and often negligible. The benefits associated with marriage not only are evident in the short-term but also endure through adulthood."
There is no reason to believe the situation in Australia is any different.[21]
Since leaving politics in 2007, former Prime Minister John Howard has made two important contributions on the issue of marriage in Australia and they both indicate the way forward. The first was in his book, Lazarus Rising, where he examines the issue of the passing of the Family Law Act in 1975, by the Whitlam Government through Gough Whitlam's then Attorney-General Lionel Murphy.
While acknowledging the need for reform in this area John Howard feared that the Family Law Bill "might tip the balance too far in the direction of diminishing the value of marriage through making it too easy to obtain a divorce."[22] In what was for John Howard, a "no more important piece of social legislation debated in the time I was in federal parliament,"[23] it ended in disappointment as the Ellicott Amendment failed in the House by one vote, 60 to 59.
The Ellicott Amendment, moved by Bob Ellicott, former Member for Wentworth, "effectively aimed to increase the period of separation as the sole ground for divorce from one year to two."[24] John Howard concluded that:
A two-year period of separation as the sole ground for divorce, replacing the old multiple-fault provision, would have constituted a profound modernisation, without the signal the bare 12-month period sent, that marriage mattered somewhat less than used to be the case. More than 30 years later, it is hard to dispute the fact that marriage has been weakened as the bedrock institution of our society. It is at least arguable that the Family Law Act has played a part in this process.[25]
Recent data in this area supports John Howard's assessment. Professor Patrick Parkinson, again, stated:
There was certainly a sharp rise in the divorce rate after the introduction of the Family Law Act 1975, as many people who had separated prior to 1975 sought a formal divorce when the ground for dissolution became irretrievable breakdown proven by one year's separation. By the late 1980s the divorce rate per 1000 married women ranged between 10.6 and 10.9. The rate over the past few years has fluctuated between 12.0 and 13.0 divorces per 1,000 married women. Around 28% of marriages entered into in 1985-1987 could be expected to end in divorce. This proportion increased to 33% for all marriages entered into in 2000-2002. The proportion of divorces involving children has actually declined over the last 20 years.[26]
Data such as this and the problems that this creates for children, that is "the rise in child abuse and neglect, and the deterioration in the psychological wellbeing of so many children and young people",[27] and for marriage in Australia should prompt an urgent review of the Family Law Act. A good start should be to expand the twelve month period of separation to two years, as the Ellicott Amendment originally proposed.
John Howard's second recent and important contribution to marriage in Australia came during the concluded 2013 Federal Election. Despite former Prime Minister Kevin Rudd's push to legislate for homosexual 'marriage' in the first hundred days of reelection being made front and centre of his campaign, the issue failed comprehensively at the ballot box and senior Labor figures recognised it as an electoral negative, such as the losing ALP candidate for the Queensland seat of Forde and former Queensland Premier Peter Beattie,[28] former Queensland Labor Senator John Black[29] and Shop, Distributive & Allied Employees' Association National Secretary, and member of the Labor Party's National Executive, Joe de Bruyn.[30]
In contrast, while campaigning in South Australia in support of Liberal candidates, John Howard "said he was against gay marriage and that 'the best environment to raise children is in an ordinary, orthodox, heterosexual marriage'.
He added: "But if you're asking my view … I think this whole argument that it's marriage equality is nonsense."
"The present (situation) doesn't discriminate against people, it just recognises not only a long-standing attitude and custom but also recognises that anything we can do to preserve current notions of marriage are more likely on balance to provide the best environment for raising children."[31]
Both contributions are sound and welcome.
Australia risks jettisoning its "bedrock institution of our society" in legislating for homosexual 'marriage', and faces a tragic fallout in the areas of social policy, children's rights and needs, threats to personal and religious freedoms, and direct harm to marriage itself – including everyone's marriage being redefined. Australia must see five fingers on a hand when five are presented, in this case the reality of what marriage is, rather than pretend that they see as real what certain pressure groups declare to be so. Australia should look to have no dealings with the issue of homosexual 'marriage', save its outright rejection, and should plan to strengthen marriage and increase its health level in our society. This will not only benefit all in Australian society, but also provide a lit beacon for other nations to follow.
Ways for strengthening marriage is the subject of another article. Until this time, readers may wish to consult Maybe 'I Do' (2012), by Kevin Andrews MP and newly appointed Minister for Social Services[32], and The National Marriage Coalition's Marriage Manifesto (2007).[33]
Gerard Calilhanna
Coordinator National Marriage Coalition
29 September 2013
[1] Penguin, Harmondsworth, Middlesex, 1954, 1982 rpt., 207.
[2] Patricia Morgan, What happens to marriage and families when the law recognises "Same-Sex Marriage"?, 1 March 2013, http://www.spuc.org.uk/campaigns/ssmsub20130301 (accessed 1 August 2013).
[3] Ibid., 1.
[4] Ibid., 4-5.
[5] Heather McCracken, 'Family First NZ faces deregistration', in The New Zealand Herald, 11:07 AM Monday May 6, 2013, http://www.nzherald.co.nz/nz/news/article.cfm?c_id=1&objectid=10881782 (accessed 19 September 2013).
[6] Kirsten Andersen, 'Air Force Sergeant claims he was fired for refusing to endorse gay 'marriage': faces court martial', in LifeSiteNews.com, Tuesday September 10, 2013, http://www.lifesitenews.com/news/air-force-sergeant-claims-he-was-fired-for-refusing-to-endorse-gay-marriage/ (accessed 19 September 2013).
[7] Jim Hoft, 'Colorado Baker Faces Up to a Year in Jail for Not Baking Cake for Gay Wedding', in The Gateway Pundit, 8 July 2013, http://www.thegatewaypundit.com/2013/07/colorado-bakery-owner-faces-up-to-a-year-in-jail-for-not-baking-cake-for-gay-wedding/ (accessed 24 September 2013)
[8] Morgan, op. cit., 10.
[9] Ibid., 11.
[10] Ibid.
[11] Ibid., 14.
[12] Ibid.
[13] Ibid., 15.
[14] Ibid.
[15] Ibid., 17.
[16] Ibid., 15.
[17] Ibid., 18.
[18] Ibid., 19.
[19] Ibid., 20.
[20]Deborah Savage, 'What Is a Mother to Do? Questions for Same-Sex Marriage Advocates', in The Witherspoon Institute: Public Discourse online, 17 June 2013, http://www.thepublicdiscourse.com/2013/06/10272/ (accessed 28 September 2013)
[21] Professor Patrick Parkinson AM with Antoine Kazzi, For Kids' Sake: Repairing the Social Environment
for Australian Children and Young People, Faculty of Law, University of Sydney, July 2011, 48, http://www.acl.org.au/wp-content/uploads/2011/09/FKS-ResearchReport11.pdf (accessed 28 September 2013).
[22] John Howard, Lazarus Rising: A Personal and Political Autobiography, Harper Collins, Sydney, 2010, 73.
[23] Ibid.
[24] Ibid., 74.
[25] Ibid., 75.
[26] Parkinson and Kazzi, For Kids' Sake, op. cit., 63.
[27] Ibid., 14.
[28] AAP, 'Gay marriage may hurt Labor: Beattie', in The Australian online, September 04, 2013 8:09AM, http://www.theaustralian.com.au/news/latest-news/gay-marriage-may-hurt-labor-beattie/story-fn3dxiwe-1226710225166 (accessed 28 September 2013).
[29] John Black, 'Where the ALP lost its longtime supporters', in The Australian online, September 14, 2013 12:00AM, http://www.theaustralian.com.au/national-affairs/election-2013/where-the-alp-lost-its-long-time-supporters/story-fn9qr68y-1226718868206 (accessed 28 September 2013).
[30] Patricia Karvelas, 'Kevin Rudd's silence on gays a 'bid to save votes', in The Australian online, August 22, 2013 12:00AM, http://www.theaustralian.com.au/national-affairs/election-2013/kevin-rudds-silence-on-gays-a-bid-to-save-votes/story-fn9qr68y-1226701643043 (accessed 28 September 2013)
[31] Tory Shepherd, 'Former prime minister John Howard campaigning in Adelaide says children are better off with mum and dad, not being raised in gay marriages', in The Advertiser online, September 04, 2013, 11:58AM, http://www.news.com.au/national-news/federal-election/former-prime-minister-john-howard-campaigning-in-adelaide-says-children-are-better-off-with-mum-and-dad-not-being-raised-in-gay-marriages/story-fnho52ip-1226709998617 (accessed 28 September 2013).
[32] Kevin Andrews, Maybe 'I Do': Modern Marriage and the Pursuit of Happiness, Connor Court Publishing, Ballan, VIC, 2012.
[33] National Marriage Coalition and other Australian Marriage Movement groups, Marriage Manifesto: Strength and Support for Australian Marriages, National Marriage Coalition, 2007, http://www.saltshakers.org.au/images/stories/attachments/221_443375_ISSUES_-_MARRIAGE_-_MARR.pdf (accessed 29 September 2013)


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Thank you for your interest in applying for a Chevening Award. Applications for all 2017/2018 scholarships and some fellowships closed on 8 November at 12:00 GMT.
If you are interested in apply for a 2018/2019 Chevening Scholarship, applications open in August 2017. Subscribe to our newsletter for updates on how to prepare and how to apply.
Next steps?
If you have applied for a scholarship, you may want to know what happens next. We have set out the next steps below.
Chevening Scholarships 2017/2018 timeline
|8 August 2016
|Applications open at 12:00 BST
|8 November 2016
|Applications close at 12:00 GMT
|From 9 November 2016
|Sifting of applications against eligibility criteria
|Mid-November to December 2016
|Independent reading committees assess eligible applications
|January to early February 2017
|Applicants are shortlisted for interviews by the British Embassies/High Commissions in-country
|By mid-February 2017
|Applicants are notified that they have been selected for interview
|27 February 2017
|Deadline to upload two valid references to the online application centre
|6 March to 5 May 2017
|Global interview period
|Early June 2017
|Announcement of interview results
|13 July 2017
|Deadline for UK university unconditional offers
|13 July 2017
|Deadline for meeting English language requirement
|September/October 2017
|2017/2018 Chevening Scholars commence their studies in the UK
Fellowship programmes will have a different timeline, please refer to your country page for further details on the timeline for the programme you are applying for.
Required documents
If you have submitted your initial application without your English language test results and your conditional offer letter, you can still upload them to your application at any point between 11 November 2016 and 13 July 2017. Please note that only documents in PDF format can be uploaded and documents cannot be over 5MB in size.
If you are eventually conditionally selected for a Chevening Scholarship, it is essential that you provide evidence that you meet the Chevening English language requirements and that you have at least one offer from an eligible course before 13 July 2017 in order to remain in the process.
Application guidance for Chevening Scholarships
Although applications have closed, you may still wish to refer to the guidance:


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Need power? This ultra low profile power supply delivers at a whopping 24 volts with 14.6 Amps!
This power supply will charge your stepper motors coils much faster and kick your machine into high gear.
It will also super heat a 3D printer's extruder and heated bed super fast with plenty of power to spare!
2 DC Outputs
Built in cooling fan
88% Efficiency
215mm(~8.50") x 115mm(~4.5") x 30mm(~1.25")
Voltage select switch 110v - 220v
UL 60950-1 Approved
Spec Sheet
You can mount this unit using Single L Brackets and M4 Screws
Warning - Be sure to disconnect power before attempting to to switch voltage.
Optional Wiring Sold Separately
18/2 Power Leads
Note: Use #6 spade connectors for crimp connectors
Power Supply should always be unplugged while you make the connections and also make sure the shield is in place before plugging the cord into an outlet.
Warning - high voltage! Always have a qualified electrician connect this unit. Use at your own risk!


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Daniel Bayu Makeup Artist
Kia SterlingHair Stylist Female New York, New York, US
My Website: WebsiteMy MM URL: http://www.modelmayhem.com/kiasterling
Mayhem # 2300824
About MeThanks for checking out my profile! I am an internationally published, session, and salon hair artist, who has a passion for hair artistry, and creating new images. I'm looking to collaborate with other experienced phenominally talented artists. who are professional, passionate, and true to their craft and who are interested in producing outstanding images. I bring professionalism, creativity, and a strong work ethic to every shoot, as well as my fun, outgoing, and down to earth personality. I'm very approachable, and I love to live, love and laugh (really hard LOL) My range is very broad and I'm very experienced in cross cultural hairstyling. My work includes and is not limited to fashion, editorial, beauty, runway,lifestyle, t.v., commercial, advertising, print, agency work, and image consulting.
I'm interested in paid assignments only however, I'm open to TFP/CD and testing depending on the professional team, and project. Available for travel, if I'm truly inspired by the project.
LET'S SHOOT!!!!!!! Looking forward to creating beautiful art with you! For rates, bookings, or interest please shoot me an email me at firstname.lastname@example.com Please include a link to your portfolio as well as the links and details regarding entire professional team, and concept of project. STAY INSPIRED...ALWAYS!!!!!!!
I'M NOT ON MM THAT OFTEN THEREFORE EMAILS ARE ENCOURAGED! PLEASE FEEL FREE TO VISIT MY WEBSITE www.kiasterling.com TO VIEW MY PORTFOLIO (link at top of page)
INSTAGRAM KiaSterlingHair
TWITTER @KiaSterlingHair
Thanks for your interest in my artistry and remember Kia Sterling Hair is a lifestyle!
Have you worked with Kia Sterling? Add Credits for Kia Sterling! >>
Credit NotesTHIS IS AN INCOMPLETE LISTING OF CREDITS AS THINGS ARE BEING COMPILED!!!!
Vogue Italia (Photo Vogue) (2x's)
Style 360 Elle.com
Mami Magazine
Denovo Magazine
Vanidoso Magazine
Hacid Magazine (2x's)
Mod Magazine
Bambi Magazine
Oppa Magazine 2x's (cover/editorial)
Nu Mode Magazine
Florum Magazine
Syn Magazine
Advance Magazine
Fantastics Magazine (cover/editorial)
Turn Magazine
Vigore Magazine (4x's) (cover/editorial)
Coiffure Magazine (cover/editorial)
Wilhelmina (NYC/PA)
Fenton Moon (NYC)
Major Model Management (NYC)
Muse Model Management (NYC)
VNY Model Management (NYC)
Red Model Management (NYC)
Request Model Management (NYC)
Q Model Management (NYC)
Mercedes Benz Fashion Week (NYC)
New York Fashion Week/lead hairstylist for Korto Momolu, Cory Couture
Philadelphia Fashion Week (lead hairstylist)
Visanthe "Shank" Shiancoe
Indique Hair
Black Wednesday
Geisha House
Von Alexandria
Autumn Lin
FBH the Agency
Omega Optical
Rashad Corey Productions
Lillie Designs
Ron Wilch (24 Hour Catwalk for Life Time TV)
WPVI ABC Evening News
WTXF FOX News
WPHL CH17 "The Eye Opener"
Daniel Bayu Makeup Artist
Jennifer Monaco Model
Gabi Cooper Model
Ashley AshLey Ashley Model
Erin Sledge Model
Alison Sileo Hair Hair Stylist
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text: Are we EVER going to get "active" homescreens? Obviously, it's not a dealbreaker for me since I've gotten the new iPhone every year since the 3G, but there are a few things I can think of that would make my homescreen personal for me. And for those of you who don't want to have an active homescreen, you wouldn't have to enable it. Is the fact that Android has them, driving Apple to never have something like that because it would look like they're copying Android? They did Message Center without getting too much grief, and their new map app is closer and maybe better than Android. I just don't see why Apple couldn't do it equal or better.


text:
Hello everyone,
I regret to inform you all that there is some "bug" ATM that will NOT allow you to post sometimes. Several of you have PM'd me with the error...
Method 501 POST to newthread.php not supported
Method Not Implemented
POST to /editpost.php not supported.
or even....
Method Not Implemented
POST to /replypost.php not supported.
If you receive any of these errors...no need for worry. Your not banned nor do you have any restrictions on your account. I don't know the cause of this problem...but I have reported it to the Admins. So whenever one of them gets online, hopefully this can all be straightened out.
On behalf of the developers and staff here at remote-exploit.org, I do humbly apologize for any and all inconveniences you have experienced. I know its frustrating cause its happened to me 5 or more times already today. Please bare with us and we will get to the bottom of this. Again, I apologize for any / all inconveniences you have or may have experienced.
If your one of the people having this or other similar issues...please speak up!
And If you have a different error or other forum problem, please post it here.
Thank you all for your patience.


text:
4 Min Read
NEWARK, Delaware (Reuters) - Assessing the U.S. economy's underlying economic trends has become more difficult because of record low temperatures and heavy snowfall across much of the nation, Federal Reserve Bank of Philadelphia President Charles Plosser said on Tuesday.
"I suspect it may be another couple of months before we have a better read on the economy," Plosser said in a speech at the University of Delaware. He characterized the weather as "unusually disruptive."
On Friday the January U.S. jobs report showed a smaller-than-expected increase of 113,000 in the number of newly created non-farm jobs versus the Reuters consensus estimate of 185,000. The unemployment rate dipped to 6.6 percent, a five-year low..
Plosser, in comments to reporters, said the data was now "noisier than usual," and therefore would take the latest round of economic data with "a grain of salt until we get some more information and presumably get a better read."
Plosser, a voting member of the U.S. central bank's monetary policy committee this year, reiterated his stance that the Fed should move faster in winding down its bond purchasing program. He called the purchases, known as quantitative easing, "neither helpful nor essential."
He expressed some surprise that inflation has remained well below the Fed's stated 2 percent target given all of the quantitative easing, but so far he's not overly concerned.
"We have done over $1 trillion of QE since a year-ago September and inflation rates have come down. If you are worried about inflation being too low it is not at all obvious the right answer is more QE," he said.
Plosser reiterated that even with January's disappointing jobs report there has been significant improvement in labor market conditions, to the point where the criteria for ending asset purchases has been met.
Beyond the asset purchases, the Fed has promised to keep interest rates near zero until well past the time unemployment falls below a 6.5 percent threshold, especially if inflation remains low.
The central bank is now buying $65 billion per month in Treasuries and mortgage bonds to depress borrowing costs in the U.S. economy, which was slow to recover from the 2007-2009 recession but strengthened toward the end of last year.
Plosser reiterated he expects economic growth of 3 percent in 2014 and the unemployment rate to steadily decline to 6.2 percent by the end of the year.
History is not on the side of the central bank when it comes to raising interest rates in a timely manner and the risk is financial markets will force its hand, Plosser warned.
He pointed out that historically it is always easier to lower interest rates to spur economic activity than to raise interest rates, a mechanism to slow the pace of inflation.
"It is the nature of the beast," he said, adding that he is concerned the Fed will once again be too late and resist raising until they are behind investors.
"Financial markets aren't always patient and they could decide it is time to raise rates and long-term rates start rising and interest rates start going up and we are going to be forced to chase them up. Then we will be behind. I don't want to chase the market, but we may end up having to do that," he told reporters.
"We may be late but the consequences may be more consequential now than in other times," he said.
Plosser reiterated the Fed has a problem communicating what it will do when economic data meets thresholds such as 2 percent for inflation and 6.5 percent for the unemployment rate.
Inflation came in at 1.l percent last year and is likely to move higher toward the Fed's target, Plosser said. On Friday, the Labor Department's jobs report showed the unemployment rate fell to a five-year low of 6.6 percent.
"We never said what we are going to do after that point," Plosser said, referring to the employment data and economic data in general.
Reporting by Daniel Bases; Editing by Chizu Nomiyama


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Glenfalloch Woodland Garden
"Glenfalloch Woodland Garden where nature reigns supreme" - Enjoy peace, tranquillity and panoramic harbour views, listen to the ripple of Russell Creek and the harmony of native birdlife. NZGT rated.
- Adulto
- Entrada Gratis
Comunícate con nosotros
Acerca de
"Glenfalloch Woodland Garden where nature reigns supreme" - Enjoy the peace and tranquillity and the panoramic harbour views; listen to the ripple of Russell Creek and the harmony of a native birdlife symphony.
Walk among the rhododendrons, azaleas, magnolias, fushias and a profusion of other flower species which integrate with native ferns, exotic imports and indigenous New Zealand trees. All further enhanced by guided tours conducted by professional staff whose knowledge and hands-on experience add an interesting and informative dimension. Guided tour booking is essential. We are an NZGT "Garden of National Significance.
Dirección física
Glenfalloch Woodland Garden, Portobello Road, Otago Peninsula, Dunedin, Dunedin - Coastal Otago, New Zealand.
Horario de apertura
- Horario comercial:
- 365 Days - Dawn Till Dusk
- Meses de funcionamiento:
- Todos los meses del año
Precios y condiciones
- Más información sobre precios:
- Free entry to gardens, Charges apply for Guided Tours, morning & afternoon teas and lunches available. Bookings essential for these group activities.


text:
What lender in sound mind would agree to renegotiate debt for a troubled nation knowing that some raptor in suspenders, with clever lawyers, could invalidate the whole deal in court? Caught between the cross and the sword, Argentina decided to take the crusade public. Here Kirchner has been masterful, sparing neither dollars nor drama. Kirchner has yet to enlist Pope Francis or the Dalai Lama, but she did dispatch Kicillof to the United Nations, the G-77 summit of developing nations, and that high court of Latin American indulgences, the Organization of American States. There, foreign companeros queued at the microphone to lambaste the loan "pirates" and their "neocolonialist" sponsors, bent on the financial version of gunboat diplomacy.
Read Full Article »


text:
Business Law
Ask a Business Lawyer. Get Business Law Questions Answered ASAP.
Are you going to a competitor? Are you going to be soliciting clients of the company with whom you entered into the contract?
No not a competitor-I guess the reference could be to the wholesaler-not soliciting clients however I do not have a client list to know who there clients are anyway excpet by looking on the web. I do not intend to go after their business.
If you do not know their customers and have not received their proprietary information and are not going to a competitor I do not think the provision in question will be applied to you. However, you should notify them immediately and in that notification point out that you never received any Confidential Information. California looks very unfavorably on non competes so as long as you are not using their proprietary information I do not see this provision being enforced.
If this answer is responsive to your question, please accept it. That is how we are compensated. It would also be appreciated if you provided feed back on your view of the answer. Finally, if the answer was especially helpful you can provide a bonus. If I can be of further assistance or you have other questions in the future you can ask for me and reach me at this site.
This communication is not intended as legal advice. A local attorney should always be consulted for legal advice. No client/attorney relationship is intended or created by this communication.
This communication is not intended as legal advice. A local attorney should always be consulted for legal advice. No client/attorney relationship is intended or created by this communication.
The question focuses around the non circumvent issue
The non circumvention is built around the confidentiality as to their customer lists and contacts. If you do not have the information as to who those are, there is no non circumvention issue. If you are not competing with them you will not be dealing with their customers in a manner that violates their rights. For example if you worked for a shock absorber distributor who sold to GM and you had a non circumvention, that provision would not prevent you from going to work for a brake manufacturer and selling to GM brakes.


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Pictures of Rachel Bilson Meeting Up With Friends For Lunch After Her Bikini Vacation
Rachel Bilson Trades Her Bikini For Heels Back Home in LA
Rachel Bilson couldn't hide her smile yesterday when she met up with friends for lunch in LA. The actress is home in California following her family vacation in Hawaii, where she wore a variety of bikinis to hit the beach and snorkel. For her meal, Rachel ditched her two-pieces in favor of her latest cute ensemble, which she paired with a brand-new Chloe bag. Fashion, rather than acting, seems to be more Rachel's thing these days, and she stays busy partying with designers and getting dressed up for magazines.
To see more Rachel, just
Image Source: AKM Images


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This may be the shortest review I have ever written for a retail release of a game. Why? Well, I honestly don't have much to say about it. I could summarize ZombiU by saying it's one of the more frustrating games I have played in recent memory, with so much missed potential. Ubisoft attempted to create something that reintroduces players to the Survival Horror genre, and while there were several moments in this game where I was genuinely creeped out, I feel ZombiU falls short of the word reinventing. While we're on the topic of falling short, let's talk about the games title...ZombiU. Really? You had to do a play on the consoles system name, didn't you? That right there makes the game seem kind of comical, because the name is so stupid. It's just a bad start to a disappointing game.
Story-wise, you're not looking at much here. There is a little bit of info here and there about the outbreak which started in the England, where the entirety of the game takes place. Throughout your adventure, you encounter various characters for short periods, and you have contact via the PA system from a bloke who is more annoying than helpful, and you can eventually unlock short cuts throughout the city to help you get around faster. If you're looking for dialogue that moves a story a long, move on from here, because there isn't any. The Walking Dead, this is not. This is a survival game. You survive, or you die, or sometimes in this case, you wish you were dead, rather than playing this game.
One of the biggest draws in ZombiU is how high the stakes are. You start as a random survivor in a subway station, eventually finding a cricket bat that is honestly the most effective weapon in the game. Yes, a cricket bat, I know, it just SOUNDS bad. You'll find a gun here and there, with some ammo, but it's nothing that'll last you a while. You'll want to save the ammunition for situations where you think you'll need it more. If you're like me, you'll be over conservative, and wait for that big moment, which never comes, you could honestly finish the game, without having fired a shot. Back to the high stakes, which are VERY high, in ZombiU, if you die, you take over another survivor, and your previous one becomes one of the infested. The key here is, with that new Zombie, lies all of the shit you worked so hard to get. Fail to kill your former player and you don't get any of it back, leaving you stranded, literally. Can't tell you how much time I spent looking through empty buildings, for anything I could find to aid me, only to take a wrong turn and get overrun by zombies, and lose everything I had. My problem with ZombiU is the repetitiveness of fighting off the horde of Zombies. Early on, one to three hits with a cricket bat will kill a Zombie. Ok, that makes sense, so yeah...eventually it could take as many as 8 hits, before a zombie is able to be finished. Imagine encountering around 3-4 zombies, and having to hit ONE of them EIGHT times, while avoiding the other ones. That's ridiculous. RIDICULOUS!
ZombiU also features the ability to loot fallen zombies, finding items to help you on your mission, but when you press that magic Y button to loot said zombies, you become completely vulnerable. I hope you made sure you killed everything in the area, because while you decide what items on the corpse are important to bring with you, Bob the Zombie whom you missed in the other hallway will wander into the room and eat your brains. It creates a rushed feeling to hurry up and grab what you need so you can move on, and it's honestly very creepy. Everytime I looted a corpse, I was on the edge of my seat, waiting on that one sum bitch Zombie to jump me. And it happened, quite a few times, actually. Also, if you're the hardest of the hardcore, you can select a mode that gives you only one single life. Average playtime for this mode, uh, about 2 hours. Speaking on my experience, that is.
The WiiU GamePad is used in interesting ways throughout the game, you can use it as a camera locator, finding different cameras that you can help the man behind the PA take over, giving him more access to the areas around you, and you completely manage your inventory from the GamePad screen. I don't feel anything used for the GamePad here is revolutionary, or had me excited about the possibilities of the console. I feel everything on that end was a missed opportunity, and that's sad because ZombiU was one of the games shown off at the WiiU's announcement at E3 2 years ago, yet here we are, and here it is, in it's unrealized potential greatness!
Multiplayer is in the game, with one player using a Pro Controller to fend off waves of Zombies spawned by the player with the WiiU GamePad. It's a mini horde mode, which is fun for a while, but eventually gets old. You can create some interesting scenarios, and in some cases you almost wish the multiplayer concepts bled over to the single player, because the action is more pumped up. Yes, I know, this is a Survival Horror game, but they can contain action to an extent without breaking the genre name calling situation. I had fun with the multiplayer, especially when I was the one spawning the Zombies, scaring the holy shit out of the poor sap I got to volunteer to play this with me. Sorry kid, you were the only one around when I needed a volunteer, at least you got to try the WiiU!
The WiiU is Nintendo's first entry to High definition gaming, and it kind of shows with ZombiU. A lot of the areas are washed out, and don't look good at all. Some scenes are really grainy, and I get that it helps to have some grain in a game in this genre, but in some places it just doesn't work. The models themselves are kind of weak and look a little plastic and lifeless (see what I did thur?) This concerns me, but I don't know who is to blame more here, the developer for being lazy and not putting the effort forth into the game, or Nintendo, who waited 7 years after Microsoft jumped into the HD game to finally make the transition. I am sure they don't regret the direction they took with the Wii and its motion controls, considering the amount of success it's had since, but getting in the HD game this late, on the verge of the next thing from Microsoft and Sony is a big mistake and it shows in these early release games. Audio in the game is fine, it creates a sense of dread, and the GamePad does a good job of playing the part of walkie talkie for your PA friend, it sounds pretty accurate to a PA system, which is cool. Having the sound coming from a second source but not mimicking what's coming from the TV is pretty cool. I hope that's taken advantage of in future games, you have two audio sources here, make good use of them!
ZombiU is missed potential. Basically. There is no story, and we can look past that, but the emphasis on survival horror is just missed here. I get it, I need to fight for my life, but the endless cricket bat bashing gets old after about 30 minutes, and this game can last for a good 10-15 hours, maybe even more if you take it REALLY slow. Ubisoft tried, and I'll give them that, but all of their concepts just seem half finished and not fully realized. Maybe this is a good introduction for the company to the WiiU system and how it works, and I can admire them for coming out the gate firing. They just missed their target, they got TreyAim or something.
Treeter's Score: 5.5


text:
If you bought a with-profits bond at the turn of the millennium, there are 364 days this year where you could face a penalty of up to 20% if you cash it in - £2,000 on a £10,000 policy.
But an estimated hundreds of thousands of customers won't face a penalty if they cash it in on the exact date of the 10 year anniversary of the policy.
Many people who bought a with-profits bond 10 years ago are being urged to dig out their paper work and check the exact date.
Strategy director of Skandia financial services, Michelle Cracknell, explains the details.
This item was first broadcast on Radio 4's Money Box on Saturday, 30 January 2010
What are these?
E-mail this to a friend


text:
Aleph Number:
Collection is open for research.
Researchers must register and agree to copyright and privacy laws before using this collection.
All or portions of this collection may be housed off-site in Duke University's Library Service Center. The library may require up to 48 hours to retrieve these materials for research use.
Please contact Research Services staff before visiting the David M. Rubenstein Rare Book & Manuscript Library to use this collection.
The copyright interests in this collection have not been transferred to Duke University. For more information, consult the copyright section of the Regulations and Procedures of the David M. Rubenstein Rare Book & Manuscript Library.
[Identification of item], E.D. Scott Account Books, David M. Rubenstein Rare Book & Manuscript Library, Duke University.
The E.D. Scott Account Books were received by the David M. Rubenstein Rare Book & Manuscript Library as a purchase in 1985 and 1986.
Processed by Rubenstein Library Staff, 1991
Encoded by Meghan Lyon, May 2011
Ebenezer Daniel Scott was born about 1825-1827 in Bristol, Gloucestershire, England to Benjamin Scott (baptised March 29, 1786 in Ditcheat, Somersetshire, England; died 1873 in Camden, New Jersey) and Eliza Owen De Boudry (born about 1785 in Bristol, Gloucestershire, England; died 1858 in Philadelphia, Pennsylvania). E.D. Scott arrived in New York on September 6, 1831 with his mother and siblings from England. He became a merchant and wholesaler to Civil War sutlers in Washington, D.C., in 1863. Following the Civil War, he appears to have operated a clothing and notion store in Minneapolis, Minnesota, from 1866 to 1868, and was prominently associated with St. Anthony's Church in that city.
Two account books, one containing an inventory of merchandise Scott sold at wholesale prices in Washington, D.C. to Union Army sutlers in 1863 as well as a separate index. It lists the sutlers and sometimes the regiments to whom he sold supplies. The other account book, chiefly 1866-1868, details the sales and the stock on hand in the dry goods store Scott operated in Minneapolis, Minn.
Sale and account book of E.D. Scott for goods sold to various sutlers of the Union Army in Washington, D.C., during 1863. One volume (31x19cm), in limp and worn marble boards and party damaged backstrip.
This volume contains 110 pages of text in ink and pencil which list the very extensive inventory of merchandise sold at wholesale in Washington, D.C., by Scott between January and September 1863. The accounts commence on January 5, 1863, with a "Bill of Goods Consigned to Wm. H. Ward (of 534 7th St.) by E.D. Scott," almost five hundred dollars worth of items. Sales were much more common than consignments, however, and included a terrific variety of goods needed by soldiers in the field - suspenders, razors, soap, "3 Gross pens," pocketbooks, envelopes, scissors, socks, "4 doz. filled ink stands," currency holders, briarwood pipes, and "2 doz. diaries," among other things.
One of the valuable features of Scott's record book is the comprehensive list of goods he furnished for resale to army units, together with the quantity of goods moved, prices charged, and methods of payment or credit extended. No less interesting are the sutlers identified by name as Scott customers. Twenty-one individual sutlers are so named, and the regiments to which they sold goods are specifically identified. Another nine sutlers may be identified in the accounts by reference to Francis A. Lord's
Additional references are made in the volume to incidental expenses, like a few "cash sales" in Washington or Georgetown and notes on express charges (for shipment of goods from Philadelphia). There are also 29 pages of entries in late 1862 for sales of dry goods and fabrics, perhaps in Philadelphia. These do not appear directly related to the 1863 sales to sutlers.
In summary, this is an unusual business record from the nation's capital during the Civil War, documenting the activities of one enterprising businessman from elsewhere who appears to have found abundant opportunities to make money in war-time Washington.
Account book of E.D. Scott, kept in Minneapolis, Minnesota, between 1866 and 1868 (with some accounts from 1847). This early record (kept within the first decade of Minnesota statehood) gives his "Stock on Hand" as of November 13, 1866, and details sales of dry goods with some earlier records of a B. Scott Senr. & Co."


text:
And after I graduated, I succeeded in finding a job in handicraft and embroidery.
Some beautiful specimens of his handicraft remain in the possession of Mr. T. M. Whitehead.
Yet perhaps he succeeded as well in it as he would have done at any handicraft.
Chemistry was for them a branch of natural science; of late years it has too much tended to degenerate into a handicraft.
Cellini was remarkable for his readiness and dexterity in handicraft.
Gudrun and the father were busy at the handicraft holiday school there, Ursula was left a good deal with the children.
We admit so much, but our handicraft was certainly not to blame.
It was while we were browsing around Ghent that the ladies discovered a bit of handicraft that seems worth mentioning.
It is a real jubilee to practise one's handicraft there on a grand scale.
If an artisan has taken a son to bring up, and has caused him to learn his handicraft, no one has any claim.


text:
It's a match I'm sure most of us have been waiting for all season — John Jay vs. Panas.
In what could very well be a possible preview of this year's Class A section final, this meeting of perennial powerhouses promises not to disappoint. The two teams have both had its streaky moments this season, both good and bad. Panas dropped back-to-back contests earlier this year to Yorktown and John Jay-East Fishkill, respectively, before catching fire in regular season and tournament play.
John Jay got off to a torrid-hot start this year, winning both the Minisink and Millbrook tournaments in addition to a brief undefeated stint before falling to Yorktown. The Indians stayed hot, but were recent swept by an equally hot (or arguably more so) Haldane team, which was just 3-5 at the time.
With Class A juggernauts opponents beating up on each other (Yorktown > John Jay, Yorktown > Panas regular season, Panas > Yorktown tournament, etc.), it will be nice to see the final piece of this trifect'A' play out. Given Panas' recent chemistry and John Jay's recent "struggles," I'm giving Panas the edge here. The fact that Panas is planning a "blackout night" for its fan section with only aid to the Panthers' home-court advantage. My official prediction: Panas wins, 22-25, 25-19, 25-23, 25-22.
I will be staying local (well, my local, anyway) to watch Clarkstown North host my alma mater, North Rockland in what should be a competitive Class AA contest. I see a ton of potential in the Rams right now, while the Red Raiders are on their way to becoming the section-title contenders they once were.
I can see this match going either way, to be honest. I think the ball is in Clarkstown North's court, both figuratively and literally. The Rams are the host and, in my opinion, the more well-rounded team of the two. Both have some talented young players, so, like I said, it wouldn't surprise me who won. Picking a side, I'm going with the Rams in five, 25-18, 21-25, 26-24, 22-25, 25-18.
Here's a look at the complete schedule, along with my predictions:
Wednesday, October 9
Roosevelt at Saunders, 3:45 p.m.
Yonkers at Gorton, 3:45 p.m.
Riverside at Lincoln, 3:45 p.m.
North Rockland at Clarkstown North, 4 p.m. — Live coverage
East Ramapo at Clarkstown South, 4 p.m.
Pearl River at Tappan Zee, 4 p.m.
Edgemont at White Plains, 4:15 p.m.
New Rochelle at Ardsley, 4:15 p.m.
Eastchester at Pelham, 4:15 p.m.
Woodlands at Palisade Prep, 4:15 p.m.
Nyack at Nanuet, 4:15 p.m.
Mamaroneck at Sleepy Hollow, 4:15 p.m.
Solomon Schechter at Tuckahoe, 4:15 p.m.
Scarsdale at Ursuline, 4:15 p.m.
Brewster at Mahopac, 4:15 p.m.
John Jay at Panas, 4:30 p.m. — Match of the night
Suffern at Warwick, 6 p.m.
Zacchio's prediction record for the season: 217-50


text:
Oven-Roasted Corn on the Cob
Recipe by Chef PotPie
I was surprised not to see this one on Zaar! Tyler Florence said, "Once you try this, you'll never have corn on the cob any other way." We agree wholeheartedly! The corn steams and cooks in it's own husk without any pre-soaking or anything. The corn's flavor is intensified right in the husk! After removal from the oven, just pull back the husk and use it for a handle. The silk comes off with the husk! Let me know if you like corn this way as much as we do!
Top Review by DEEP336
This is indeed an excellent way of preparing corn on the cob, especially for a large number of people. However, for the sake of energy savings, as well as time, try doing this in the microwave. I do mine 3mins. for one ear, 4 mins for 3, etc. My MW is a 900W oven, yours could be 700, 900, or 1000W, so times can vary. There are several recipes in the DB. For six or more people a traditional oven still works wonders! Thanks, Chef PotPie!
See Discussion:211 Reviews 1 Tweak 2 Q&As
Ingredients Nutrition
- 6 ears corn on the cob, in their husks (Or however many will fit in your oven.)
- water, to rinse them
Directions See How It's Made
- Preheat oven to 350°F.
- Rinse ears.
- Place corn cobs directly on middle rack in oven.
- Bake for 30 minutes.
- Remove corn cobs. Pull back husks and enjoy!


text:
Cat Country's Psychic Picks Winning Mega Million Numbers!
Cat Country Psychic Artie Hoffman has picked the winning numbers in the Mega Millions $540M Jackpot – and, you can benefit!
Here's the deal:
Artie has chosen what he thinks is the winning combination for the drawing. We are purchasing a ticket – and, we're willing to split the jackpot with you!
All day today, we're filling up our lottery ownership agreement with 107 names. (107….. we're 107.3 – get it?) First, we're taking care of Artie – then, Georgia, Chris Coleman, and myself. You can add your name as a partial owner of the $540M ticket just by listening and calling in today. From now until 7pm, we'll ask you to call in at certain times and get on the ownership list. Just listen to Cat Country 107.3 or catcountry1073.com and be ready to call in when we tell you to. The number is 609-370-1073.
By the way, splitting up $540 Million ain't too bad – we'd all have equal shares of $5,046,728.97.
So, good luck and get ready to hop aboard the money train!
If you're one of the 107 shareholders, make sure to listen Monday morning at 7:20 when we announce what the numbers were – and, how much money we're splitting.
By the way, get the story on Artie Hoffman by clicking here.


text:
Meeting the national interest through Asia literacy — an overview of the major stages and debates
Henderson, Deborah J. (2003) Meeting the national interest through Asia literacy — an overview of the major stages and debates. Asian Studies Review, 27(1), pp. 23-53.
|Accepted Version (PDF 106kB)
This paper traces the evolution of ideas on the question of how Australians might become Asia-literate. It examines the main phases in those government and non-government reports on Asian languages and studies that called for a national strategy for Asia literacy. As well, it explores the major debates about the place of the study of Asia and its languages in Australian education. It contends that the Council of Australian Governments (COAG) commission and acceptance in 1994 of Asian Languages and Australia's Economic Future, known as the Rudd Report (Rudd 1994), was the culmination of more than three decades of debate and lobbying. Also, it argues that the Rudd Report's ambitious long term plan, aimed at producing an Asia-literate generation to boost Australia's international and regional economic performance, was unprecedented.
First, an overview of the significance of the Rudd Report is established. Second, the main stages in those reports and documents that advocated the study of Asia and its languages are identified. Third, the core debates surrounding such phases are traversed in order to establish the contested nature of the context for the study of Asian languages and cultures in Australia, prior to the 1992 COAG brief which commissioned the Rudd Report.
Impact and interest:
Citation counts are sourced monthly from Scopus and Web of Science® citation databases.
These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.
Citations counts from the Google Scholar™ indexing service can be viewed at the linked Google Scholar™ search.
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|ID Code:
|Item Type:
|Journal Article
|Asia literacy, export culture, regional engagement, Australian studies of Asia, policy prescription
|Australian and New Zealand Standard Research Classification > STUDIES IN HUMAN SOCIETY (160000) > POLITICAL SCIENCE (160600)
Australian and New Zealand Standard Research Classification > EDUCATION (130000)
|Current > QUT Faculties and Divisions > Faculty of Education
|Copyright Owner:
|Copyright 2003 Taylor and Francis
|Copyright Statement:
|First published in Asian Studies Review 27( 1):pp. 23-53.
|Deposited On:
|25 Jan 2006 00:00
|Last Modified:
|29 Feb 2012 12:58
Export: EndNote | Dublin Core | BibTeX
Repository Staff Only: item control page


text:
Size 772.636 MB 0 seeders Added 2012-02-01 11:45:46
Actor Ralph Fiennes makes his feature directorial debut with this adaptation of William Shakespeare's play about a fierce warrior who forges a bond with his arch-nemesis after being exiled by the very people he once fought to free. When the barbarous Aufidius (Gerard Butler) seizes Rome, Gen. Caius Martius, aka "Coriolanus" (Finnes) responds by swiftly suspending civil liberties. Later, after repeatedly clashing with the Voluscians, Coriolanus faces an even more treacherous enemy in the form of two power-hungry officials (James Nesbitt and Paul Jesson) who ultimately succeed in having the decorated war hero excommunicated from Rome. Enraged, Coriolanus bonds with Aufidius over their mutual hatred of Rome, and together the two men plot to shake the pillars of the city. When Coriolanus' fails to heed the warnings of his mentor Senator Menenius (Brian Cox), it falls on the vengeful warrior's mother (Vanessa Redgrave) to avert the coming disaster. Unrated, 2 hr. 2 min. Mystery & Suspense, Drama Directed By: Ralph Fiennes XviD | English | avi | 608x256 | XviD @ 760 Kbps MP3 @ 128 Kbps | Genres: Comedy | Romance Uploader Note: When 1gb version will be available will be uploaded also if you want better quality in bigger size Note:If you have something to offer as early releases,seedboxes, links,accounts,etc please contact us on torentz 3xforum ro Seed Stats: 20-400 GiB at aprox 10 MiB/sec/20 slots per torrent How To Get Your Maxspeed (uTorrent) Torrent Client - Preferences - Bandwidth - Number of connections - Set aprox. 500 for each Torrent Client - Preferences - BiTorrent - Protocol Encryption - Forced Bandwidth Allocation - High (Set download/upload limit - Unlimited) Stop Other Active Torrents - Start downloading and wait for connections. Enjoy and Seed for at least 1:1 ratio. Don't forget to say thanks/leave reviews. Before downloading you should check/google search sample "release name""sample". Greets to all actual/future p2p/scene QUALITY groups and affiliate websites. Don't trust IMDb robot or bad ratings,always watch some trailers first. Ignore stupid comments/fake/mislabeled/no-DVDrips/CAM/TS/RAR uploads. Please spread this release/torrent to your friends/forums/etc. If you need translation subs visit some subtitles sites. Report if you see online streaming or other spam links. Recommended movie player VLC PLAYER.
|Coriolanus (2012) DVDRip XviD-MAX.rar
|Torrent downloaded from TorrentState.com.txt


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text:
This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
There is increasing evidence that the intracellular antioxidant enzyme paraoxonase 2 (PON2) may have a protective function in the prevention of atherogenesis. An enhancement of PON2 activity by dietary factors including flavonoids is therefore of interest. In the present study we determined the effect of quercetin on paraoxonase 2 levels in cultured murine macrophages
Paroxonase 2 is an antioxidant enzyme ubiquitously expressed in human tissue including endothelial cells [
Quercetin is one of the major flavonoids, ubiquitously distributed in (edible) plants [
In the present study we demonstrate that a quercetin supplementation up-regulates PON2 mRNA and protein levels in RAW264.7 murine macrophages in culture. As
The underlying molecular mechanisms by which flavonoids may induce PON2 gene expression in RAW264.7 cells have yet not been fully elucidated. It has been reported that flavonoids from pomegranate affect the DNA binding activity of the transcription factor AP-1 [
Following the assumption, that quercetin supplementation has resulted into increased PON2 mRNA and protein levels
Furthermore, it needs to be taken into account that following absorption in the gastrointestinal tract, quercetin is intensively metabolized leading to methylated derivatives as well as conjugates with glucuronic acid or sulphuric acid [
Quercetin dihydrate (>98% purity) and quercetin-3-glucuronide (purity 98%) were obtained from Roth (Carl Roth GmbH, Karlsruhe, Germany). Isorhamnetin (≥95% purity) was purchased from Sigma (Deisenhofen, Germany). Cell culture medium and supplements were obtained from PAA (Coelbe, Germany). A 100 mmol/L stock was prepared with quercetin and Q3G in DMSO and stored at −20 °C until use. The primers used for the polymerase chain reaction (PCR) were obtained from MWG Biotech (Ebersberg, Germany). Western blotting reagents and materials were purchased from Bio-Rad (Bio-Rad Laboratories GmbH, Muenchen, Germany) if not otherwise stated.
The murine macrophage cell line RAW264.7 was purchased from DSMZ (Braunschweig, Germany). The cells were cultivated in Dulbecco's modified Eagle medium (DMEM), high glucose, supplemented with 10% foetal bovine serum, 100 U/mL penicillin and 100 μg/mL streptomycin. Cells were grown under standard conditions in a humidified incubator at 37 °C and 5% CO2.
In order to study whether the test compounds may affect cell viability, murine macrophages were incubated with increasing concentrations of quercetin and Q3G (10–100 μmol/L) for 24 h. Cytotoxicity was evaluated by neutral red assay [
For experiments, cells were seeded at an initial density of 0.5 × 105 cells per cm2 and incubated with quercetin in increasing concentrations (0, 1, 10 or 20 μmol/L), Q3G or isorhamnetin (10 μmol/L) for 6 h (RNA) or 24 h (Western blotting).
Human monocytes originated from a subgroup (20 volunteers; 11 M, 9 F) of a recently performed quercetin-supplementation study in overweight/obese subjects (mean BMI 31.6 kg/m2) with high-cardiovascular disease risk phenotype at Kiel University [
Quercetin dosages were selected to represent the 15-fold the estimated daily quercetin intake in Germany of about 10 mg. Subjects were assigned to placebo or quercetin groups by blocked randomization procedure, separately for men and women. Capsules (quercetin or placebo) were handed out at days 0 and 21 of each treatment period and leftovers were collected at days 21 and 42. Compliance with treatment was 98%.
Fasting venous blood samples were taken at the first and last day of the treatment periods. Monocytes (CD14 positive) were isolated from EDTA-blood by density centrifugation with LymphoPrep™ (retailer Progen, Wieblingen, Germany) and successive positive selection with magnetic beads (Miltenyi Biotec, Bergisch Gladbach, Germany) as described previously [
Murine macrophages were lysed with TRisure reagent (Bioline, Luckenwalde, Germany) and RNA isolated according to the manufacturer's instructions. RNA was quantified photometrically (Spectrophotometer DU800, Beckman Coulter, Krefeld, Germany). Quantitative real time PCR was performed as one step procedure using SensiMix™ One-step Kit (Quantace, Berlin, Germany) with SybrGreen detection using the Rotorgene 6000 cycler (Corbett Life Science, Sydney, Australia). Quantitation was done by use of a standard curve. Primers were designed by standard tools (Spidey, Primer3, NCBI Blast) and purchased from MWG (Ebersberg, Germany). Primer information is given below (
Macrophages were harvested by scraping and lysed in RIPA buffer (50 mmol/L Tris-HCl, 150 mmol/L NaCl, 0.5% deoxycholate, 0.1% sodium dodecyl sulphate (SDS), and 1% NP-40; pH 7.4 with Protease inhibitor cocktail, 1:100; Sigma, Saint Louis, USA) by incubation on ice for 30 min and subsequent centrifugation at 12,000 g (4 °C, 30 min). Protein concentration was determined in the supernantants by the BCA Assay (Pierce, Illinois, USA). 40 μg protein was separated on a 12% SDS/polyacrylamide gel and transferred onto an immunoblot polyvinylidene fluoride membrane. The membrane was blocked with 3% non-fat dried milk in Tris-buffered saline, pH 7.4, with 0.05% Tween-20 (TBS/T) for 2 h and probed with rabbit anti-PON2 antibody (1:500; abcam, Cambridge, UK) at 4 °C overnight. Then, the membranes were incubated with a goat anti-rabbit IgG secondary antibody (1:4,000) conjugated with horseradish peroxidise for 45 min. Specific bands were visualized by enhanced chemiluminescence (ECL) reagent on a ChemiDoc system and quantitated densitometrically by using the program Quantity One®. The membranes were stripped (strip buffer: 8 g glycine, 2.5 mL HCl, 1 L H2O) and subsequently incubated with rabbit polyclonal antibody against α-tubulin which was used as loading control (1:800, Santa Cruz Biotechnology, Heidelberg, Germany) and proceeded as described above. The predicted sizes for PON2 and α-tubulin are 40 and 55 kDa, respectively, which were checked by the use of molecular weight markers.
The statistical analysis was performed with SPSS Version 15.0 (Munich, Germany). Data were tested for normal distribution (Kolmogorow-Smirnov and Shapiro-Wilk test) and analysed by t-test. In the case of non-parametric data, Mann-Whitney
Overall, current data indicate that quercetin supplementation may increase PON2 levels in cultured murine monocytes
This project was financially supported by a grant (entitled "Functional foods for vascular health–from nutraceuticals to personalized diets") of the German Ministry of Education and Science (BMBF 0313856A).
PON2 protein levels in RAW 264.7 macrophages as determined by Western blotting. Cells were treated with quercetin (0, 1, 10 and 20 μmol/L) for 24 h. The shown immunoblot is one representative out of two independent experiments. α-Tubulin was used as a loading control. * indicates significant differences (p < 0.05) in comparison to untreated control cells.
Effects of quercetin, quercetin-3-glucuronide (Q3G) and isorhamnetin on PON2 mRNA levels in RAW 264.7 macrophages. Cells were incubated 10 μmol/L of quercetin and Q3G for 6 h. Bars indicate means ± SEM of 3 experiments performed in duplicate. β-actin was used as a house-keeping gene. * indicates significant differences (p < 0.05) in comparison to untreated control cells.
Effect of a 6-week supplementation with quercetin (150 mg/d) on PON2 mRNA levels measured in CD14-positive monocytes of human volunteers (n = 20) with a high cardiovascular risk. β-Actin was used as house-keeping gene. No significant differences between groups regarding PON2 mRNA levels were determined.
Cytotoxicity data for quercetin and quercetin-3-glucuronide. RAW264.7 cells were incubated with increasing concentrations of the test components and cytotoxicity was determined by the neutral red assay. Bars indicate means ± SEM of 3 experiments performed in triplicate. * indicates significant differences (p < 0.05) in comparison to untreated control cells.
Primer sequences and conditions for real time PCR experiments.
|murine β-actin
|murine PON2
|human β-actin
|human PON2


text:
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text: On Feb 7, 2012, at 3:55 PM, Artur Skawina wrote: > On 02/08/12 00:32, Sean Kelly wrote: >> [...] the transitivity of shared can still make for some weirdness at the implementation level. For example, if I have: >> >> class Thread { >> pthread_t p; >> shared void detach() { >> pthread_detach(p); >> } >> } >> >> Building this yields: >> >> Error: function core.sys.posix.pthread.pthread_detach (_opaque_pthread_t*) is not callable using argument types (shared(_opaque_pthread_t*)) >> Error: cannot implicitly convert expression (this.p) of type shared(_opaque_pthread_t*) to _opaque_pthread_t* >> >> So I either need to speculatively update a bunch of system API calls to add a 'shared' qualifier to everything I think will always be used in a shared context, or explicitly cast away shared when actually passing these variables to their associated API routines. Neither option is appealing, so again I haven't done anything regarding shared. > > An overload would work, right? > > class Thread { > pthread_t p; > shared void detach() { > pthread_detach(p); > } > void detach() { > pthread_detach(p); > } > } The shared call still won't work because pthread_detach accepts a pthread_t, not a shared(pthread_t). It might work if pthread_t weren't a pointer type, but that obviously can't be safely assumed. This is a tiny bit like when static arrays were changed to be passed by value. This applies to the C API as well, regardless of the fact that C has no notion of passing arrays by value. But at least in that case the type of the parameter didn't change based on the calling context.


text:
Did You Know?
Why is it important for you to get involved in your child's life?
Children who know that their parents are there for them, no matter what, will have
more strength to get through the tough times.
Having involved, caring adults in their lives is an important factor in preventing
children from turning to alcohol and drugs.
Parents who are active in their children's lives are better able to see when the
children are stressed out or unhappy and, therefore, at risk of alcohol abuse.
Children who have a strong and warm relationship with their parents take better
care of themselves, are more independent, and are more able to make decisions on
their own.
Allow for "together time" daily. How you spend time with your children
is more important than how much time you spend with them. Children like having even
15 minutes a day where their parents share time only with them. This time does not
have to involve big plans. It can be as simple as talking while preparing dinner,
going to the library, taking a walk, working on a craft project, telling jokes,
or getting an ice cream cone.
Value your child's accomplishments. Watch your child at what he
or she likes to do and join in if you can. Praise your child's basketball skills
or performance in a concert. Ask to try out your child's new video game. Your participation
and encouragement says that these activities are worthwhile and that you acknowledge
what is important to your child.
Motivate your child through positive feedback. Recognize good behavior
consistently and immediately. Praise your child even for ordinary efforts such as
getting up on time, helping to set the table, or finishing homework without being
told. This positive feedback motivates your child to continue following the rules
and perhaps even to exceed your expectations.
Use informal family meetings to share concerns, ideas, and opinions.
For some families, mealtime is the perfect opportunity to have discussions and to
teach children the value of self-expression through lively but polite conversation.
Car trips and walks together are two other good opportunities for talking over family
issues. It's helpful to plan specific times for family meetings, but also be open
to unscheduled discussions as needed, even if they occur at busy or inconvenient
Watch for signs of stress.
Here are some signs:
If you see signs of stress, talk with your child, let your child know that you care,
and work together to solve the problems that create the stress. If the stress continues,
seek outside help.
When your child is under stress …
Children under stress are more likely to turn to alcohol to find relief from stress.
These suggestions can help prevent your child's stress from building to unsafe levels: