text:
Free weekly email packed with travel tips for major world cities, great competitions and exciting features.
Were you to flip Norway on its head, its uppermost reaches would stretch all the way down to Rome, whereas Oslo would barely cross the North Sea. That should give some idea of the majesty and grandeur of this country's expansive northern landscape, which many consider to rival New Zealand's South Island for otherworldly splendour...
Trolls may be a buzzword for the Twitter-fed generation, but their centuries-old antecedents, the mythical straggle-haired creatures said to terrorise the peaks and valleys of Northern Norway, have long informed the folklore of this vast swathe of Scandinavia. Stay at the fjordside Kobbelv Vertshus and you may well be treated to tales of these malevolent critters as you gaze over the tranquil waters, dining on succulent cuts of local reindeer. Fear not, though: trolls rarely make an appearance during the permabright summer months, and cynics maintain that they were invented to warn intrepid children of the winter dangers of heading unaccompanied into the lavish mountains. A canoeing excursion onto the nearby lake Sørfjordvannet requires a short hike and the surrender of photographic equipment – just in case.
Not to be confused with the flaxen-haired pop brethren of the late 1990s, Hamsun (first name Knut) was Northern Norway's most celebrated – and debated – author, paving the way for the likes of Thomas Mann, Franz Kafka and Ernest Hemingway with his pioneering psychological writings, which at once romanticised and critiqued his formative years in the region. Hamsun won the Nobel Prize for literature in 1920, but subsequently provoked widespread revulsion for his support of the German war effort and his dogged refusal to denounce Nazism. The museum and educational centre built in his memory is suitably controversial: a menacing, black cube of a building juxtaposed with the neat low-rise structures of surrounding Hamarøy.
Tranøy's coastal sculpture park grew out of an overachieving fundraising drive originally intended to save Harald Bodøgaard's temporary 'Stars Fishing in the Sky' sculpture from relocation. That rusty work now serves as a the starting point for all kinds of artsy indulgence, thanks to a rotating roster of open-air exhibits that are displayed amongst the municipality's rocky waterside outcrops. A hearty post-trail meal at local café Dorotheas (think freshest local salmon and a house speciality cinnamon bun) should satisfy earthlier cravings before boarding the car ferry that crosses the Tysfjorden – the deepest fjord in Northern Norway – as part of the European route E06 highway.
Situated well above the Arctic Circle, Narvik became the unlikely focus of the world's attentions in April 1940 when Hitler attacked Denmark and Norway. For eight weeks solid, a bitter battle for this industrial community and its prized reserves of iron ore raged between the invading German forces and allied troops, eventually resulting in Nazi occupation. Nowadays, the majesty of this year-round, ice-free port – predominantly a conduit for Swedish trade – is best appreciated via the cable car to Fagernesfjellet, which offers stunning, peaceful views and the possibility of venturing further up into the surrounding mountains by foot.
Using locally-harvested moss as a nutritious garnish for fish from the nearby fjord, and the rhubarb that flourishes at its edges, the traditional kitchen at the Tinja Mountain Lodge, a mountainous drive from Narik, would no doubt be a Michelin star magnet were it not for its relative remoteness. A welcome drink in a traditional tepee comprises sweet coffee around a smoky campfire, swathed in the skins that have cloaked the Samis for generations. The Sami people are Norway's indigenous, semi-nomadic reindeer herders, whose heritage has only relatively recently been recognised as a source of national pride.
The word 'arctic' is derived from the Greek word for bear (arktos) and there are plenty of native shaggy bear specimens to be photographed – and fed – within the vast expanses of Bardu's amazing Polar Zoo. Elsewhere at the zoo, the slinky lynx can be glimpsed through the fences, strutting its feline stuff, but Wolf Camp is undeniably the park's biggest draw. Offering visiting humans a rare opportunity to bond with socialised wolves and to enjoy their company, close-range, in an environment that's as near as possible to their natural habitat, it's a daily expedition that involves allowing wolves to lick your face, before – if you're lucky – witnessing the almighty din of their collective howls.
So-nicknamed because of its status as a relatively cosmopolitan, not to mention fashionable, trading post, Tromsø – Northern Norway's most populous city, with 70,000 inhabitants – is well known as a winter base for glimpsing the Aurora Borealis, which ripples across the sky when it so chooses. In summer months, dinner at harbour restaurant Fisekompaniet offers a guaranteed, spectacular view over the prized wooden buildings of Tromsø's historic centre and out onto a still snow-capped landscape of the surrounding mountains. Walk the bridge over to the spectacular, modernist Arctic Cathedral, designed by architect Jan Inge Hovig, for a haunting midnight concert in surreal surroundings.
It's a dog's life at Tromsø's renowned Villmarkssenter, where some 300 tethered Alaskan huskies – prized in winter for propelling sleds full of tourists towards the Northern Lights – await your attention in kennels set amid a grandiose landscape, bordering an open-air restaurant and an inviting hot-tub. If you're looking for a more active time on the water, the staff here can organise a beginners' kayaking expedition on the strait between Kvaløya (The Whale Island) and Tromsø city, where the German battleship Tirpitz was destroyed by British Lancaster bombers on 12 November 1944. That around 1000 perished in these tranquil waters is almost unthinkable.
Norwegian flies from Gatwick to Oslo, then on to Bødo airport.
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text: Finally its time to surf after what seems like months but was really only a week or two----this whole next week the forecast is saying good things and should be in the thigh to stomach high range with somewhat clean conditions! im stoked to try out my new 6'2 Lost to see if it really is a speed demon.:D

subset: commoncrawl


text:
For immediate release
January 10, 2012
COLCHESTER, VT–(Marketwire – January 10, 2012) – Seeking to recover costs resulting from Vermont Yankee cooling tower failures in 2007 and 2008, the state's two largest distribution utilities have filed a lawsuit against Entergy-Vermont Yankee (Entergy) in Vermont Superior Court in Windham County.
"This case arises out of Entergy's breach of its contractual obligation to use 'Good Utility Practice' in its management and operation of the Vermont Yankee Nuclear Station," Central Vermont Public Service and Green Mountain Power said in a joint statement today. "Entergy's failure to implement and exercise sound practices with respect to the maintenance, repair and improvements of the facility's cooling towers caused tower failures in August 2007 and July 2008. The failures resulted in significantly reduced power output, which in turn deprived us of power due to us and our customers at specified, below-market prices."
In the first instance, a tower failure on Aug. 21, 2007 caused the plant to reduce output by 65 percent for 11 days. A subsequent Nuclear Regulatory Commission investigation blamed the failure on over-tightened bolts and salt and fungal degradation that went undetected by Entergy. The NRC found the failure to find the problem was the result of Entergy's reliance on "remote" inspections, rather than direct, hands-on inspections.
"In failing to carry out hands-on inspections, Entergy failed to take into account considerable and relevant industry operating experience that had previously identified the importance of that kind of direct examination," CVPS and GMP said. "That led directly to the first tower failure."
In the second tower failure in July 2008, the plant reduced output for 12 days. This failure was caused by failed pipe supports within the tower. In both cases, CVPS and GMP contend that Entergy's failure to use "Good Utility Practice" led directly to the failures.
"The failures and omissions of Entergy in managing and operating Vermont Yankee led directly to both tower failures," the companies said. "This was a clear breach of Entergy's obligations under its power purchase agreement with CVPS and GMP."
The companies are seeking compensatory damages of $6.6 million to cover increased power costs and lost capacity payments resulting from the tower failures, plus interest and all legal costs.
"We filed this action only after lengthy efforts to reach a settlement with Entergy," the companies said. "Due to the statute of limitations and Entergy's failure to accept responsibility for its failures and contract breaches, we reluctantly must take this action now."
The companies have requested a trial by jury.


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Chair's Challenge to the Thayer Class of 2013
Terry McGuire, Th'82, Chair of the Board of Overseers, has challenged the Class of 2013 to make a pledge this year to be paid during their first year as alumni.
Those who make a pledge of $20.13 or more will receive a Challenge T-shirt.
* Required
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Email address:
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I pledge to make a gift to Thayer School Annual Fund between July 1, 2013 and June 30, 2014.
Please enter amount of pledge:
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All Class of '13 pledgers have the choice to be entered into a drawing to participate in the sumo wrestling competition to be held this Thursday, May 9 at 4PM in the Atrium.
YES! Please enter me into the drawing to compete in the preliminary sumo wrestling competition!
No thank you, I prefer to participate as a spectator.
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Those who pledge $20.13 or more will receive a Challenge t-shirt.
If your pledge is $20.13 or more, please indicate your t-shirt size.
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I vote for the Class of 2013 gift from the Chair's Challenge to be applied to:
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Technical instruction and support (in Couch and other labs)
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Contributions to the Thayer School Annual Fund directly support the most critical needs at our school by helping bridge the gap between tuition and the actual cost of a Thayer School education. Your gift helps keep tuition costs down and allows Thayer students to continue to receive the excellent education that we benefitted from.
Thayer Student Philanthropy Council: Siddharth Agrawal, Jennifer Demers, Brad Ficko, Kevin Griffith, Daniel Harburg, Robert Harrison, Kaitlin Keegan, Steve Reinitz, Regina Salvat, Mark van Eeghen
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In 1998, EWF and IIW agreed on transferring the EWF Qualification System to IIW. IAB will be the structure within IIW that will up date the EWF system documentation (Guidelines and Rules) and will implement these as an IIW Qualification System.
This International Education, Training and Qualification System for Welding Personnel is recognised worldwide and supported by industry and by international training and accreditation entities, opening the way towards one Global Education and Qualification System for Welding Personnel.
This System is recognised by ISO namely on the ISO 14731 – Welding Coordination – Tasks and Responsibilities, as a way for a Welding Coordinator to gain his welding technical knowledge, as stated on the standard Annex A.
In order to administer this system and to develop it, the IIW has established the IAB – International Authorisation Board. This IIW Working Unit aimed at the effective integration of the EWF and IIW systems and its implementation in all IIW countries, publishes Guidelines for training and develops and manages the Quality Assurance procedures controlling the system.
An organisation recognised by the national IIW member is appointed as (ANB) Authorised National Body for the supervision of the Qualification System in each country. Representatives from these ANBs form the Operational Management within the IAB, and appoint IIW Assessors to ensure conformity of each ANB to the agreed Rules.
Until the end of 2011, more than 80.300 IIW diplomas have been awarded worldwide.
The IIW Directory of Access Conditions defines for every country the access requirements to the courses based on the IIW Guidelines for Education, Examination and Qualification. This information can be obtained from the Authorised National Body (ANB).
People interested in obtaining an IIW diploma that are already qualified due to previous education and experience, should contact the Authorised National Body (ANB) in their country for additional information.
For more information go to the list of Approved Guidelines.


text:
Raytheon launches WAAS payload to improve GPS accuracy for air travel
Raytheon Company has launched its GEO 6 satellite payload into orbit for its 12-year mission. It is the latest payload to support the Federal Aviation Administration's (FAA) Wide Area Augmentation System (WAAS), which enhances the reliability and accuracy of GPS signals for directing air travel. The Raytheon-developed payload is a key element of WAAS, which offers commercial, business and general aviation... read more


text:
CAC Movie - Monsters University (G)
When Saturday September 28, 2013 @ 8:00 PM (1399 days ago)
Where Science Center, 106, Auditorium
Duration 1 hour 44 minutes
A look at the relationship between Mike and Sulley during their days at Monsters University — when they weren't necessarily the best of friends. Voices by: Billy Crystal, John Goodman, Steve Buscemi.
General $2.50
Intended Audience General Public


text:
"You look tired, Cocom," said Jack, passing him a flask of aguardiente.
They desired not to eat or to drink—not even of my aguardiente, which is the best.
It was aguardiente of El Paso, better known among the mountain-men as "Pass-whisky."
Was he drunk with aguardiente, or had his jealousy turned his brain?
Would you like some aguardiente de pesco, some mescal, or some chica?
Goes to gateway, but pauses at table, and begins to fill a glass of aguardiente.
A four-gallon keg of aguardiente, from which we dealt out half a gill daily to each man, kept our Indians in good humor.
Have, also, these flasks of aguardiente; you will need sustenance.
Add to this a refreshment-room, refectorio, full of the rarest old cigarros, and redolent of aqua de soda and aguardiente.
Peradventure, a person filled with aguardiente or the whisky of the Americans.


text:
Aurore Top— $ 348.00 $ 104.40
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100% Cotton
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Shipping Information
Email email@example.com
Phone +1 212 343 2300
All purchases are shipped via FedEx. Customers have three shipping options: FedEx Ground = $15.00, FedEx 2nd Day = $25.00, FedEx Next Day = $45.00. Orders are processed Monday through Friday, excluding holidays or expedited orders placed after 1pm EST will ship on the next business day. Saturday delivery to residential addresses only. International Shipping cost does not include any duties, tariffs, and/or taxes.
Only full price items and non-final sale items are eligible for return and refunds are only given in the original form of payment. In order to receive a full refund on a return, less the return shipping cost, of a full price or non-final sale item(s) such returned product must be returned to Jill Stuart within 14 days of receiving the order and must be in the original condition with all tags attached.


text:
Double Registered Fox Trotter for sale in Schoolcraft
Very Stylish Seasoned Missouri Fox Trotter Trail Riding Gelding
SubcategoryFox Trotter
Age9 yrs
Height15.1 hands
LocationBenton, MO 63736
"Barron" is a good looking sorrel Missouri Fox Trotter gelding with silver through his mane and ...
$ 3,000
Beautiful 5 Year Old Bay Missouri Fox Trotter Trail Riding Gelding
SubcategoryFox Trotter
Age5 yrs
Height13.3 hands
LocationBenton, MO 63736
"Peanut" is a beautiful 5 year old Missouri Fox Trotter gelding. He is a rich bay. He is 13. 3 ...
$ 2,500
Good Looking Black Missouri Fox Trotter Trail Riding Gelding
SubcategoryFox Trotter
Age9 yrs
Height15.1 hands
LocationBenton, MO 63736
"Bandit" is a good looking black Missouri Fox Trotter gelding. He has a blaze face, rear socks and ...
$ 3,500
Cremello Registered Missouri Fox Filly
SubcategoryFox Trotter
Age3 yrs
Height14 hands
LocationHuntsville, TX 7...
Cream is a sweet little filly out of a very sweet, in-your-pocket mare. We don't believe she's ...
$ 1,500
black and white fox trotter
SubcategoryFox Trotter
Age13 yrs
Height14.3 hands
Color -
LocationAustin, AR 72007
Poncho is a 13 year old black and white registered Missouri Fox Trotter gelding. He is 14. 3 hands ...
$ 2,500
Beautiful Black Gelding Gaited
SubcategoryFox Trotter
Age11 yrs
Height15.2 hands
LocationFarmington, MO 6...
Mack is a very nice 1/2 foxtrotter1/2 walkerHe is good gaited and very quiet. He is quiet and ...
$ 3,700
White Missouri Fox Trotter Mare
SubcategoryFox Trotter
Age8 yrs
Height15 hands
LocationHuntsville, TX 7...
Abby is an eight year old MFT. She's been saddle broke, though it's been a while since she's been ...
$ 1,000
Excellently Trained 4 yr old Foxtrotter Cremello Gelding
SubcategoryFox Trotter
Age4 yrs 6 mths
Height14.3 hands
LocationWillard, MO 65781
Your not going to find one better than this guy! ! I was training him to keep him for myself, but ...
$ 3,000
Blue-papered Trail Mare
SubcategoryFox Trotter
Age7 yrs 8 mths
Height14.2 hands
LocationBartlett, 38136
This mare is very people-oriented, athletic, a quick learner, and is built like a tank. She has a ...
$ 2,300
Beautiful Buckskin Fox Trotter
SubcategoryFox Trotter
Age4 yrs 4 mths
Height14.2 hands
LocationLe sueur, MN 56058
Hazel is a 14. 2h 4 year old registered MFT mare. She's well gaited and has been trail ridden ...
$ 5,200


text:
Lexi has faced personal struggles, but nothing has prepared her for the most perilous battle of her life.
Shifters are on the brink of war as Northerners target Colorado in an attempt to infiltrate the borders. Texas winds up on the hit list, and the Weston pack prepares to fight for their land...and for their lives.
Austin's courage is put to the test when rogues want to seize his land and slaughter his pack. But that's not all he's facing as two shocking revelations turn their lives upside down. His love for Lexi is unwavering, but their future is uncertain.
Will the local packs set aside their differences to fight together, or will this be the end of peace among Shifters? Stand witness to the epic conclusion of the Seven series.
©2016 Dannika Dark (P)2016 Tantor
I O'Farrell
The emotion that Lexi's character shows.
Both, but more tears with this book.
When war hovers over their state, the Western Pack have to make some tough decisions. Lexi feels like she's at her weakest and most vulnerable when all hell descends on their territory. She has to rely heavily on the pack's strategies, but all the while knowing that anything could go wrong at any given time.
This book is so full of tension it overtook my life for several hours because I had to know what happened. I spent the first half of the book biting my nails and the second half wiping tears away. This is another brilliant addition to the Seven series with a few new characters thrown in. I hope this series never ends.

Just love all the books!! Please please keep bringing more out!! Just amazing xxx xxx
"Great end to a enjoyable series of books"
loved the whole series always something new and unexpected. Will miss the Western Pack now.
"I hope there will be more from Dannika"
Well what can I say as all Dannikas books I was hooked wanting more still.
"Brilliant and humour filled, sexy and beautiful"
Truly wonderful, Dannika Dark started this series of seven books with a bang and she has delivered amazing book after amazing book .
My only complaint is that now Dannika Dark's Seven series has sadly finished, I will have to go looking for another author and series with excellent storylines. Plots filled with lots of detail. Characters full of depth and lovable imperfections. A sense of humour, sex and passion.
We all know how rare they are to find
"An amazing ending to a brilliant series"
Absolutely loved this series. The characters are so well formed and the individual stories are beautifully written. Dannika Dark did an amazing job with the character and world building that you can connect with everyone which wad especially aided by the brilliant narrator. I am sad to see the books end but I was not left disappointed by anything!
"Good story end to series"
Since I'm not able to read anymore, my eyesight lacking audible books are my savior. Good listening series like this one are perfect. Great book!
"Make this a movie series please"
I hope this series becomes a movie maybe along with the Mageri series and I bet you would agree?
"Damn that Lean"
excellent series. My sister and I enjoyed listening to every book, sorry to have it end. But looking forward to more from Dannika
"Wow!!! What an ending."
This story was amazing if you're not a fan then you need to be because this series is beyond great. It surpassed all my expectations and it definitely had a good amount of everything. The witty banter, sarcasm, anger, happiness, despair, betrayal, and a whole lot of steamy hot sexiness to go round
"I want more!!!"
I know this is the last book but this series has touched my heart do deep and it can't be beat :) For those of you who haven't read this series you are missing out. Danika Dark draws you into a world that is so wonderful , entertaining and brings each character to life that you as if you know each one. The narrator is perfect and draws you in even more and when it comes to audio books a narrator can make or brake a book. I'm sad the series is over but blessed to have listened to a true series of love, loss , betrayal, war, but best of what family should truly be.
"The best"
One of the best series that I've listened to. Kept all the characters alive and active in every book. Great Listen!!!
"Great book!"
I loved this whole series. I didn't want to stop listening. It's hard to not fall in love with the characters.
"Phenomenal ending!"
Be prepared to cry. Not what I expected for the storyline, but entrancing all the same. The final chapters were heart touching.
"Great series"
Every book in this series was very very good. The story line in each book fit well with the others once you start you cannot stop until you have them all. Narrator was on point
"Awesome serious youngish can't stop reading or listening."
I went through this whole series in less than a moth. If I didn't have obligations, I would have completed the listening about the Weston Pack and friends/allies in a week because it's just that good! I am glad I savior each one. I hope there is more on the horizon as you fall in love with all the characters, well maybe not the bad guys but you will know what I mean when you read or listen to these books. The narration was awesome. I don't like to give the story away but o am glad they did two books on Lexie and Austin. The writer showed the characters from other character's views which is a nice talent to have as she did a great job! I can't wait to read/ listen to more. I spent more than one night without much sleep because I couldn't stop listening. The character development is definitely a five star. If I could give more stars, I most certainly would. I am not a shifter reader but I think the author has changed my view and I will be reading and listening to more shifter books. I enjoyed these books immensely. Please write more on this series!
Report Inappropriate Content
If you find this review inappropriate and think it should be removed from our site, let us know. This report will be reviewed by Audible and we will take appropriate action.


text:
Lina Kim DDS
Laurelhurst Office
4540 Sand Point Way NE
Suite 340
Seattle WA 98105
(206) 985-0232
Magnolia Office
3150 W Government Way
Suite 1A
Seattle WA 98199
(206) 402-3904
Refer a Friend
A successful practice doesn't just happen. It is the result of a strong commitment to excellence in our treatment and in our relationships with patients and doctors. We'd like to take a moment to thank you for showing your confidence in our practice by recommending us to your friends, family, and colleagues. We're gratified to find how many new patients regularly call on us based on your words of advice.
We want to reward you for your support. When you refer your friends and loved ones you pay us the highest compliment possible. We want to show you that we appreciate your confidence in our services.
For every 2 people you refer to our practice we will send you a $25 gift certificate from a store of your choosing from the Rewards for Referrals list.
Choose a form:
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If you are a patient of record who has referred a new patient to us, please let us know by filling out and submitting the following form.
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text:
Never did a more beautiful youth come down from the hills of the Latin Quarter.
He too was a discoverer, but his discovery was of Paris and the Latin Quarter.
But if you only knew what lives those fellows lead, in the Latin Quarter with their actresses!
Gregory arrived at his hotel in the Latin Quarter about ten.
The quarter of Paris in which it stood, known formerly as the Latin Quarter, long preserved a peculiar stamp and physiognomy.
The fame of your first appearance has reached even the Latin Quarter.
Now a cock crows lustily in some neighboring yard; the majority at least of the Latin Quarter has turned in for the night.
The Latin Quarter blazed in silence and the gates of the great schools were shut.
Below Therese, some tarts from the Latin Quarter were dancing in a ring on a patch of worn turf singing an infantine roundelay.
A garret underneath the roof, off there in Paris, in the Latin Quarter!


text:
Adobe updates Muse visual Web designer
Adobe's visual Web design tool gets a new upgrade.
Review: SmartFlex Card for iPhone 5
If you're traveling light, the SmartFlex Card for iPhone 5 lets you leave the wallet at home.
Review: SmartFlex View for iPhone 5
If you spend a lot of time using FaceTime or viewing videos and other content on your phone, the SmartFlex View is an excellent choice.
Review: CandyShell Flip for iPhone 5
A flip-back panel lets you dock your iPhone 5 without removing it from the case.
Four Speck cases for the iPhone 5
Speck has a great lineup of cases for the iPhone 5. Here's a look at four models, each of which offers different levels of protection and functionality.
Review: CandyShell Grip for iPhone 5
A tight grip and a thin, form-fitting case provide natural protection for your iPhone 5.
YesVideo iOS app makes old home movies new again
New app lets you view VHS tapes, slides, and even old film reels on your iPhone and iPad.
Adobe launches first public preview of Edge Reflow Web design tool
Edge Reflow debuts as part of Adobe's Edge Tools & Services suite.
Dropbox snaps up SnapJoy photo service
The file-sharing giant extends its photographic reach with acquisition of fledgling photo sharing service.
Hands on with YouTube Capture for iOS
YouTube, the outfit that defined online home video, has released an app that makes shooting and uploading a snap.
Adobe updates Photoshop, boosts Creative Cloud services
Adobe used its Creative Live event to spotlight updates to a range of its creative products and services.
Adobe ships Acrobat XI featuring new cloud services
New version of Acrobat touts increased integration with cloud services such as Adobe EchoSign for electronic signatures and FormsCentral for forms creation and data collection.
Quark unveils new HTML5-based App Studio
New version of mobile device content creation tool emphasizes HTML5 and the cloud.
Hands on with Camera Awesome for the iPad
SmugMug's iPhone photo editing app makes its debut on the big screen.
Articles by Jackie DoveNext Page


text:
Another Hollywood awards show, another three hours of noxious self-congratulation, the usual snubs and surprises, and conservatives whining about "Hollyweird" doing something liberal.
It's not hard to understand why conservatives hate Hollywood — there's an undeniable bias towards all things liberal, and smug celebrities typically subscribe to the school of limousine liberalism — but much of last night's indignation was hackneyed and, at times, hilarious given how the night panned out.
The outrage started almost immediately, after HBO's Sarah Palin film Game Change won the early awards for Best TV Miniseries/Film, Best Actress in the genre (Julianne Moore as Palin), and Best Supporting Actor in the genre (Ed Harris as John McCain).
The Perpetual Outrage™ brand of conservatives came out of the woodwork to express their anger that the liberals in Hollywood would give any sort of award (however meaningless) to an HBO movie that portrayed their lowly 2008 presidential election hero in any way other than how she or they would like her to be portrayed.
Fox News radio host and nominee for "King of Being Upset About Things" Todd Starnes tweeted off a frenzy of complaints, lambasting the awards as "honoring Hollywood thuggery," and contributing to the "War on Women" by celebrating such a TV film.
Further fueling the conservative indignation was the fact that Game Change producer Jay Roach took a rather mild (considering the subject) jab at Palin: "Now with [Julianne Moore] and Tina Fey, we have three of the most incredible impersonations of Sarah Palin… counting Sarah Palin," he said.
Starnes continued his fury by saying the awards ceremony had turned "into a night of Palin-bashing," and calling on President Obama to condemn the Palin "bullying." Roach's speech was eyeroll-worthy when he called Moore "brave" for playing Palin, but to say that one little joke was part of a night of unending "Palin-bashing" is a tad overwrought.
Conservatives Whine About Liberal Hollywood And 'Palin Bashing' At Golden Globes, Ignore CIA's Big Night
Current Status: Published (4)
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, Up:
1.37.1 CompiledBlock class: instance creation
new: numBytecodes header: anInteger method: outerMethod
Answer a new instance of the receiver with room for the given number of bytecodes and the given header.
numArgs: args numTemps: temps bytecodes: bytecodes depth: depth literals: literalArray
Answer an (almost) full fledged CompiledBlock. To make it complete, you must either set the new object's `method' variable, or put it into a BlockClosure and put the BlockClosure into a CompiledMethod's literals. The clean-ness of the block is automatically computed.


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Nicki Minaj didn't sleep her way to the top!
Nicki Minaj says she has not slept her way to the top!
She says, quote, "When I started being around Young Money, Lil Wayne thought I was shy, but it wasn't that I was shy, I just didn't want anybody to think I was easy."
Source: Hip Hollywood


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2019 Ford Focus Wagon spy shots Spy Shots
52 minutes ago
52 minutes ago
First Drives
Auto Shows
Spy Shots
Car Tech
Scott Dixon negotiates the hairpin turn in morning warmup - Anne Proffit photoEnlarge Photo
Unlike most races, there are quite a few drivers and teams that have opted to begin on the black, primary tire rather than the softer, short-wear alternate red Firestone Firehawk.
Everyone must use new alternates for at least two green flag laps during every INDYCAR race.
The first five drivers (all using Honda engines) in this 85-lap race around the 1.968-mile, 11-turn Long Beach street circuit are using the alternate, red Firestone: polesitter Dario Franchitti, Josef Newgarden, Justin Wilson, Simon Pagenaud and Scott Dixon, while Honda driver Takuma Sato, who went off this morning during warmup starts sixth on the primary Firehawk tire. The balance of the top 10 will use the alternate Firestone: 2011 winner Mike Conway, Graham Rahal, Charlie Kimball and Lotus driver Alex Tagliani.
Behind this group comes the Chevy corps, with pole winner Ryan Briscoe, Will Power and Ryan Hunter-Reay all choosing the primary, while Honda driver James Jakes in 14th runs the alternate Firestone. Chevy drivers EJ Viso and James Hinchcliffe will start on the primary, as will Lotus' Simona de Silvestro, Chevy drivers Helio Castroneves and Tony Kanaan, with Chevy's JR Hildebrand on alternates, completing the first 20 grid spots.
Of the final six drivers all but one is using primary Firestones, with last-starting Katherine Legge looking to move up on alternate Firehawks. They are Chevy's Marco Andretti (who qualified on the primary), Rubens Barrichello, Oriol Servia (Lotus), Chevy's Ed Carpenter and Lotus driver Sebastien Bourdais.
While there have been no further discussions in the paddock about a turbocharger change made by Honda this weekend, we did find out the A/R referred to in the rules designates "the area of the turbine inlet over the distance from the shaft which is the radius of the curve of the passage at that point," according to INDYCAR's director of engine development Trevor Knowles.
"The manufacturers have a choice so they can pick small ones for road courses and large ones for ovals or circuits where top-end power may be better than low-end torque," he told me.
In morning warmup, there were several drivers jumping curbs at the fifth turn and ending up in the tire wall. Hunter-Reay was quickest, followed by Dixon, Barrichello, Power, Viso, Briscoe, Kanaan, Jakes, Kimball and Pagenaud completing the top 10. Franchitti ended the session with his T5 off and his Target team is completing repairs in time for the race.
The weather is--as it normally is for race day--beautiful today in Long Beach, with clear skies and moderate temperatures, which should be just right for the expected 1:17PM green flag start.


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12" Germany
- Tech-House
- jack008pt3
- joyce muniz - sleepless
- homework - by definition
- round table knights - each time
- o&a (osbourne anderson) - alligator jazz
In a land that has no ego and a table that has no head, Round Table Knights are constantly pushing their talents as DJs and Producers to the limits and evolving with the output. Hailing from Bern, Switzerland Round Table Knights were originally a four man scratch DJ collective with a penchant for hip-hop, rock, electro and jazz.
�We fell in love with House Music because it�s a very wide and open kind of music, you can put whatever influences in there. If you do it with your own style and with taste it�s a very good thing�
Following a stellar EP on Deadfish, 2010 saw their first EP for Made to Play get signed on the spot by Jesse Rose and go on to become one of the catchiest outputs to date, with support from everyone from Luciano to Annie Mac in her Glastonbury set. The resulting avalanche of productivity and popularity snowballed further with �Cut To The Top� featuring the legendary Swiss garage-rock legend Reverend Beat-Man on vocals and combining elements of garage, blues and of course their irrefutable house beats.
Never delivering an output that could be considered �typical� their kudos as remixers was also duly noted with projects on Gomma and Defected turning some serious heads and their remix of Tensnake�s Coma Cat going on to become Pete Tong�s Essential New Tune. Upcoming projects include a remix of Jesse Rose�s �Non-Stop� on Made to Play and remixes for Modular and Loungin� Recordings plus the release of their debut artist album �Say What?!� on Made to Play in Feb 2011.
After a ten year journey, the Swiss Beardies have less �Cut To The Top� than mixed, scratched and grafted their way up there and with a member who already gets mistaken as Claude VonStroke it seems the sky is the limit for the bearded masters of forward thinking, surprising house music.
5 Artikel. Du siehst: 1 bis 5.
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so good ep
VÖ-Datum: 28.02.2013
Label: off
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VÖ-Datum: 21.12.2012
Label: hive audio
Yolanda Be Cool ft. Crystal W.
Le Bump
VÖ-Datum: 20.08.2012
Label: spinnin
penner & muder
presence of another man (noir rmx)
VÖ-Datum: 23.07.2012
Label: jackmode
5 Artikel. Du siehst: 1 bis 5.


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Father: Albert Franklin Powell b: 5 JAN 1818 in Columbus Co., NC
Mother: Narcissa Dorsey Wooten b: 4 APR 1823 in Columbus Co., NC
RootsWeb.com, Inc. is NOT responsible for the content of the GEDCOMs uploaded through the WorldConnect Program. If you have a problem with a particular entry, please contact the submitter of said entry. You have full control over your GEDCOM. You can change or remove it at any time.


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Reuben Nunez is the new police captain for the Town of Marana. Nunez, who will start on Sept. 5, will receive an annual salary of $100,000.
Nunez is coming to Marana after serving the Tucson Police Department for more than 27 years. He was a commander for 11 of those years.
"From a personal standpoint, I am thrilled to have Captain Nunez assume his new position," said Marana Police Chief Terry Rozema. "He has a reputation for being a knowledgeable, competent, hard-charging, workhorse who simply goes out and gets the job done. Having worked with Reuben for more than two decades, I know his experience, enthusiasm and leadership will enable us to continue respected and highly regarded agencies in the State of Arizona."
Nunez will serve as the department's second in command, His duties include day-to-day management, oversight and leadership of administrative/support services bureau, including criminal investigations, communications, records, crime scene investigations, internal affairs, homeland security, volunteers, recruiting, training and policies and procedures.
"I'm excited about the opportunity to be a member of the Marana Police Department," said Nunez. "Serving the citizens of Marana will be my duty and honor and working with Chief Rozema and the men and women of MPD will soon be one of the most professional, well-respected and highly regarded agencies in the State of Arizona."
Nunez holds a bachelor's degree from Northern Arizona University.


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What did Jesus really look like? Since there was no Kodak Easy-Share to be found in all of Galilee, we can only speculate whether Jesus looked more like Jim Caviezel (The Passion of the Christ) or like Willem Dafoe (The Last Temptation of Christ).In December 2002, the magazine Popular Mechanics featured a cover story titled "The Real Face of Jesus." Based on information gleaned from forensic anthropologists, author Mike Fitton concluded that Jesus stood only 5'1" tall, and he had curly hair … [Read more...]
What Did Jesus Really Look Like?
December 11, 2011 by Leave a Comment


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Dumaguete Vacation Packages
About 110,000 people call Dumaguete in Visayan Islands home.
Dumaguete is located about 400 miles (644 kilometers) southeast of the national capital Manila and 80 miles (129 kilometers) southwest of Cebu Island.
If you want to surround yourself with nature, plan a trip to Mount Talinis and Lake Balanan Park, two scenic places where visitors to Dumaguete like to visit on a fine day. Go for a hike through the park and discover the biodiversity of the area then stop for a snack in the reserves' beautiful surrounds.
Malatapay Market is the perfect place to go to if you have a passion for shopping and watching the world go by. This is a bustling area filled with interesting fashion, quirky accessories, fresh produce and great places to eat.
Siaton Plaza is one of the most iconic civic spaces in in the Dumaguete area. It's one of those special places that visitors often return to time and time again.
Dumaguete's star attractions sometimes overshadow its lesser known, but equally fascinating sights such as the Dauin Church.


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February 13, 2003
Kathleen Reedy, M.S., R.D.H.
Health Scientist Administrator
Executive Secretary, Arthritis Advisory Committee
Dept. of Health and Human Services
Food and Drug Administration – HFD-21
Center for Drug Evaluation and Research
5630 Fishers Lane – Room 1039
Rockville, MD 20857
Re: Review of AVAVA
Dear Ms. Reedy:
I have been invited to provide an external expert review of an FDA memorandum dated November 7, 2002, co-authored by Drs. Renan Bonnel and David Graham and sent to Dr. Lee Simon, regarding ARAVA and its possible association with acute liver failure (ALF) and other serious hepatotoxicity. In my review, I will: 1) review and comment upon the methodology presented in this memorandum; 2) provide an interpretation of the results; and 3) offer some suggestions regarding alternative approaches for evaluating safety.
As Professor and Head of Biostatistics and Yale University School of Medicine, I have been involved in clinical studies research since 1977. My publication record includes development of new methods for clinical trials design, conduct, and analysis. Also, I have been co-author on numerous publications reporting results of clinical studies. My experience includes government, academic, and pharmaceutical-affiliated research activities, including both pre- and post-marketing activities. My full curriculum vitae are attached as an appendix.
A. Case Definition
The authors identified 102 cases from the FDA's Adverse Event Reporting System (AERS), and reviewed the events to quantify drug causality. The authors indicated intensive efforts were made to obtain followup from reporters and/or health care providers to aid in their assessment. This is an important task when conducting safety reviews. While the authors acknowledge the importance of obtaining followup, there was no evidence to suggest the nature and extent of these activities. Moreover, the memorandum concludes on page 17 that the case reports were of poor quality and many reports lacked important data. "This combination imposed a significant handicap on risk assessment efforts."
Case definitions were provided on pages 4-5. For category 1 (non-fatal but severe and potentially life-threatening), it is not clear that "jaundice not requiring hospitalization" necessarily is a "non-fatal but severe and potentially life-threatening" event. Inclusion of such events, if not really severe, would inappropriately increase the total number of events. Moreover, this type of event does not seem equivalent in severity to their second criterion in this same category of liver injury requiring hospitalization. For category 2, the authors specify a list of liver-related events that must occur within 3 months of the development of liver-related signs or symptoms of jaundice in order to meet the criterion of "acute." The authors state that in some case reports, no timing was provided and classification was based on the narrative, suggesting a rapid time course. The number of such cases needs to be provided and results interpreted in light of the uncertainty associated with these data.
The causality assessments were categorized as: 1) probable/likely, 2) possible, and 3) unlikely. It is not stated whether the definitions were specified before the cases were reviewed, but it would be strongly preferred if the categories had been defined a priori. The definitions were vague, increasing the likelihood that subjectivity and bias would be introduced into the classification process. For example, "probable/likely" is an "hepatic event, including test abnormality, occurring in a plausible time relationship to drug administration." A "plausible time relationship" is vague; a precise time period should have been specified. The "event is unlikely attributed to concurrent disease or other drugs," is equally vague and subjective. A "possible" hepatic event included a lab test abnormality, occurring in a plausible time relationship to a drug. Again, no specification was provided as to what was "abnormal." For values outside normal limits, what did the laboratory value have to be before it was "abnormal" (e.g., 2X or 3X)? Was the test, if outside some limits, repeated? Finally, a "possible" hepatic event included subjects with "factors present that could plausibly have contributed to liver injury, but were not the most likely explanation for the adverse event." This vagueness invites misclassification and possible introduction of bias. In summary, the authors used liberal definitions of causality that tended to include cases, where others may have removed such cases.
Forty-eight cases were classified as "unlikely," and the remaining fifty-four cases were "possible" and "probable/likely" (page 5). Among the fifty-four cases, the authors stated, "The serious hepatic event was attributed to leflunomide and leflunomide was the primary suspect drug." This is an overinterpretation of seriousness and attribution based on the definitions above. Also, this result is misplaced in the methods section of their memorandum, since it precludes any analyses yet to be presented.
The authors point out further difficulties in ascertaining the nature and extent of liver adverse events, including but not limited to: 1) insufficient information was provided to classify 35% of reports with respect to laboratory values, 2) liver biopsies were reported in only five patients, 3) data on the duration of ARAVA therapy prior to onset of liver injury was available in 41/54 patients, 4) specific information on timing for assessing temporality was not always provided and classification was only suggestive, and 5) forty patients received medication concomitantly that are labeled for hepatotoxicity. Concomitant drugs did "not appear to have been responsible for the acute hepatic event, or leflunomide was as likely to be the causative agent" (note this definition differs in a subtle way from "possible" above, where leflunomide had to be the more likely explanation).
In summary, every case report plays a key role in the calculations provided in the remainder of their memorandum. Thus, there is a need for clear, unambiguous definitions that would place all cases into appropriate categories for subsequent analyses and interpretations of results. There are substantive ambiguities in the definitions, assumptions that were made in classifying patients, and inadequate description of the steps taken to acquire additional case report information when information was lacking in order to reach a reliable conclusion. The nature and extent of requests made to clarify issues, and the success in acquiring additional information, would have been helpful in gauging the adequacy of the case report assessment procedures.
National Prescription Audit Plus data from IMS showed the number of US prescriptions of ARAVA from initial marketing in Fall, 1998 through May 2002. The authors used Tennessee Medicaid (TN) and United Health Care Group (UHG) data to determine persistency of drug use (a necessary prerequisite for their survival and hazard analyses). In their memorandum, Figure 1 shows the persistency of drug use from these two sources. The authors conclude the median duration of use was 4-5 months. Unfortunately, the authors do not define "persistency," nor do they indicate why they selected the TN and UHG databases. Other data sources should have been included (or at least mentioned) to provide an objective assessment of persistency, especially since the median drug use data reported here seems low.
I have been involved directly in research involving large databases such as TN and UHG, and persistency depends on numerous factors. Among these factors are switches and discontinuation of the drug. If a patient had a 2-3 week lapse between prescriptions, was this no longer "persistent"? Or, must discontinuation occur for some longer period of time before drug use is no longer "persistent"? If a subject switched to some other drug for a short period of time (e.g., 2 weeks), and then switches back to ARAVA, has persistency ended? What if a switch from ARAVA occurred, and the new drug was for long-term use taken for one month when an ALF endpoint was reached? Is the adverse event "probably caused" by ARAVA according to the methods in the memorandum? Or, was this assessment of relative causality made in the presence of both drugs and their timing? Such clarifications are crucial in order to feel confident about categorization of case reports.
Moreover, persistency can be affected by issues unrelated to drug termination, including but not limited to: 1) formulary change, and 2) individuals switching to different health care plans. In summary, the persistency information in the memorandum requires further clarification in the presence of these real-life drug use practices and the peculiarities in which these data were collected and recorded. For, persistency plays a major role in the authors' survival and hazard function analyses. If persistency is longer than suggested by the authors, the risk estimates in their memorandum would be reduced, perhaps substantially.
For instance, assume that a patient on average takes ARAVA for 50%-100% longer than reported by the authors, a value consistent with other data sources. Then the number of person years-at-risk would be increased 50%-100%, to account for the longer duration of drug use. Thus, the numbers in Table 6 would be reduced. For example, for the "probable only ALF group," the values of 73-133 events per one million person-years (see Table 6) could be reduced to 37-67 events per one million person years (without changing the number of events). Moreover, the numbers in Table 6 are subject not only to "denominator" changes in person-years, but also to "numerator" changes in the number of case reports attributable to the drug. Reductions in the number of causally-linked case reports would reduce these values even further. In summary, the results in the memorandum are subject to wide variation. When one sees data that are subject to substantial variation as we see here, it is common practice to perform sensitivity analyses using various assumptions. Because this was not done here, the robustness of the results presented in Table 6 remains unexplored. It appears that the authors used "worst-case" estimates that may be prone to substantial bias.
C. Survival Analysis
Drs. Bonnel and Graham use the information described up to this point, to perform survival and related hazard analyses. The survival analysis and its implementation in this situation are non-standard.
In their survival analysis section, the authors draw from a number of different, noncomparable data sources (i.e., IMS, TN, UHG, and case reports from AERS) to obtain Table 7. This table gives the number needed to product one case report of ALF at 6 and 15 months. These results are obtained from a noncomparable array of different data sources, each with their own (unstated) strengths and limitations. A good deal of discussion (not provided) is needed to justify why data from disparate sources are combinable. Because the assumptions, coding, and methods used to collect data in each of these databases may not allow them to be combined for survival analysis, the survival analysis results should be viewed with caution.
Specifically, the authors use the persistency data, person-years of observation, and case reports (drawbacks of both noted above) to perform a survival analysis. The persistency data and person-years at risk are derived data, and not actual data as is the case in standard survival analysis. Thus, the objectivity and familiarity with standard survival analysis calculations is not present here. The consequences of using derived data include: 1) the estimates of variability and associated confidence intervals were not properly calculated in the memorandum, since these quantities ignored the extra variability associated with the derived nature of these data, 2) the survival and hazard estimates could vary substantially depending on selection of alternative data sources, and 3) use of derived data make specific estimates provided in the memorandum difficult to replicate independently (as I attempted briefly but unsuccessfully to do).
Their results should be made more transparent by exemplifying the calculations. Second, the persistency data, number of person-years at risk and true drug-related adverse events may not be representative. A more balanced analysis with statements of alternative assumptions and results would be desirable. A downward adjustment of their estimates of risk is likely, the magnitude of which could be large. Finally, the combinability for survival analysis is a major source of concern.
My final remark for this section is that one always would like to validate results from a complex modeling process with actual data. Tables 8 and 9 provide numbers that may be sufficiently small to check against the observed data in the TN and UHG databases. For example, Table 9 says that at 6 months the number of subjects needed to produce one case report of probable or possible ALF or other severe liver injury is 2,074. What do the data from the TN and UHG data show? The authors nowhere in this memorandum acknowledged validation as an issue. Comparison to known databases, either those presented here or others, is needed to reliably assess the safety data.
The section on hazard analysis is subject to the same issues as the survival analysis section above, and so I summarize my remarks here: 1) the need for transparency of calculations, 2) recognition that a number of different data sources (with unstated strengths and weaknesses) were required to perform calculations, and their combinability for survival analysis is a major source of concern, 3) the need for sensitivity analyses that evaluate other reasonable estimates of risk, persistency, and person-years of duration, 4) recognition of the need for model validation and, if possible, comparison to actual data, and 5) the width of the reported confidence intervals need to be broader to properly incorporate all variability.
D. Underreporting
The authors point out that underreporting is a serious concern, since serious adverse events are commonly not reported in the AERS. They refer to a number of well-known articles, many of which were published prior to the late 1990s. They update earlier tables in their memorandum with new tables that assume reporting of adverse event rates of 5%, 10%, and 25%. Thus, the respective increases in number of events are 20, 10, and 4-fold. The types of events discussed in this memorandum are dramatic and unexpected, so it is not clear that life-threatening ALF and related liver toxicity events are underreported to the magnitude suggested in the memorandum. In addition, there has been more recent and appropriate increased emphasis for reporting adverse events to the FDA. The magnitude of this problem, as it applies to this particular drug class or disease since 1998, also is not well documented. In summary, while an underreporting problem likely exists, it is sheer speculation what the rate is. Underreporting is simply another parameter in the modeling process that needs to be examined within a full sensitivity analysis.
The authors indicate (page 17) that ". . . the quality of cases can vary widely. Our overall assessment of leflunomide case reports of ALF and other severe liver injury was that they were generally of poor quality. There appeared to be little or no effort at followup for most of the cases reported. Associated with this, many case reports lacked important laboratory data as well as information relating to ultimate patient outcome. This combination imposed a significant handicap on risk assessment efforts." In summary, followup of case reports to adequately assess the nature and extent of liver-based adverse events seems unsatisfactory. The actual number of cases in the ARAVA safety evaluation is therefore subject to wide variation.
E. Additional Remarks
Because of ambiguities of case report data, and whether the primary analysis should be "probable plus possible" or "probable only," a sensitivity analysis was performed (see Table 12). Several analyses were performed, such as an exploratory analysis of the scores using a 25% percentile. There is no reason to select this particular cutoff; others are equally plausible and may lead to substantively different conclusions. Other analytic methods are presented, such as boxplots. But they add little to interpreting these data because the boxplots (Figure 6) summarize data from models that transform the raw vote data to a different scale; nothing new is achieved through their scoring system.
Inspection of Table 12 shows that there are three cases (of the sixteen) in which there is majority agreement by two distinct groups within the FDA. The authors state that "possible reports" were included in their analyses as linked to ARAVA, although information provided in the case reports was incomplete (page 20). The authors conclude that excluding these events as drug-related would be biased, since additional information (if somehow gathered) would lead these reports to be upgraded in their level of certainty. This is speculation. My experience leads me to a different conclusion, where more information often can lead to excluding events, or to a reduction in the extent of causality. There is simply no way to make any firm conclusion about bias, and this argues for examining data from existing studies and/or new studies.
The authors evaluate methotrexate and liver injury (pages 20-23) to develop a risk-benefit analysis of ARAVA. However, these studies are from a different era, when adverse event reporting behavior was much different than today. Also, the nature and extent of collecting efficacy information probably differed greatly as well. So there is a lack of comparability between these older studies and the current ARAVA information. In addition, the methotrexate studies have very small sample sizes which preclude the identification of rare but significant adverse events. Another limitation is that "most sequential liver biopsy studies were based on relatively small numbers of patients' (page 23). Both of my issues are exemplified in the authors' remarks that "the best single study may be that of Buchbinder, et al., which appeared in 1993 and had 587 RA patients (page 22).
On page 24, the authors evaluate ARAVA data and indicate that the "last observation carried forward" overestimated the true response rate. Dr. Paul Leber and others at the DA years ago used this method, because it was a conservative approach to drug evaluation (i.e., it underestimated the drug's true efficacy). In the ARAVA setting, it would similarly underestimate the true response rate.
Additional efforts, beyond those presented in this one memorandum, are required in order to assess the safety profile of this drug. Additional studies need to be examined or performed. One type of study would be an observational cohort study, in which events are clearly defined and analyses performed. If at all possible, any events identified through a computer search would have the subject's chart available for review to confirm the diagnosis, the event temporality, etc. All concomitant and other relevant information would be assessed in order to eliminate the ambiguities as noted earlier in my report. Because very important adverse events found in large post-marketing experience are rare, it is not too great a burden to fully understand the nature and extent of all the treatment "twists and turns" and prognostic characteristics of each individual. Such information is crucial to determining the nature, extent, and degree of causality between the drug and the adverse event.
Another type of study would be a case-control study. A third type of study would be a properly conducted meta-analysis, which the FDA has relied upon in past reviews of drug safety. No matter what the study design, a well-designed study should have a protocol that outlines all aspects of the study including hypotheses, endpoints, methods of case ascertainment and patient selection, etc.
In summary, the authors have attempted to address an important public health issue regarding drug safety. I raised questions regarding case ascertainment and assessment of the degree of drug causality. The resolution of how these cases are classified has a dramatic, multiple-fold effect on the stated results. Some of the case report deficiencies are intrinsically inherent in this type of investigation, however, and so these remarks are not intended as a criticism of the authors per se.
The authors have performed a useful attempt at addressing a difficult picture. However, the combining of disparate data sources required to perform survival and hazard analyses represent a novel analytic approach, which needs to be explored more fully before its reliability is answered. Also, the unstated underlying assumptions by the authors all seem intended to maximize the estimate of risk. I recommend that assumptions be explicitly stated and sensitivity analyses be performed that embrace the variability inherent in this process.
Because of these unresolved issues, these results represent a small piece of the safety puzzle for ARAVA. These data alone do not provide a sufficiently robust picture from which to draw full and reliable conclusions. Additional data and analyses from other sources are needed.
Robert W. Makuch, Ph.D.
Professor and Head, Biostatistics
Yale University School of Medicine


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I missed this episode of Family Guy.
But at least I have seen the best part: Peter going to a Christian "Straight Camp":
I missed this episode of Family Guy.
But at least I have seen the best part: Peter going to a Christian "Straight Camp":
Hemant, the whole episode is on Hulu: http://www.hulu.com/watch/61211/family-guy-family-gay#s-p1-so-i0
Watched it last night…pretty hilarious.
We're sorry, but you're not American enough to watch this video.
The best part is actually the brain-damaged horse…
Man, I bet straight camp is just like AA where they make you confess to a higher power or some crap. Why can't there be secular straight camps?!?
Somehow, every time I see a link to a Hulu video I click on it, somehow thinking that this one, magical time, they will invite us friendly Canucks to take a gander. Alas, no. I do the same thing with Comedy Central videos.
The best part is a conversation between Brian and Stewie about how homosexuality. Stewie shouts out a bible verse from Leviticus and the conversation goes something like this (can't remember exactly):
Brian: You're blindly quoting bible verses and you can't even read.
Stewie: Welcome to America, man.
That's priceless.
If I pretend to be American will you let me watch the clip? I could get an oversized hat, a bible and a gun and claim to be from Texas.
Yes I am not American enough to watch either
I saw the episode on Sunday night. It was funny, but I wish they didn't go so simple-minded on the straight camp's methods. There was a goldmine of comedy in that scenario and they merely went with straight gay-bashing (literally).
btw – The American Dad episode where he befriends an atheist conservative is one of my all time favorites.
I thought the episode was funny, and also touched on some extremities that I have seen gays exhibit. It also highlights what general Christians do, quote scripture without the real knowledge of what's the true meaning..
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Blackjack Mulligan (b. Robert Windham in 1942, d. 2016) and Blackjack Lanza (b. Jack Lanza in 1935) were a Professional Wrestling Tag Team as The Blackjacks. They came together as a team in 1973 and competed for the AWA, WWE, and various territories. They were 1x WWA (Indianapolis) World Tag Team Champions, 1x NWA Texas Tag Team Champions, 2x NWA American (World Class) Tag Team Champions and 1x WWE World Tag Team Champions.As usual, you can find the basics at The Other Wiki.
"Blackjack Tropes":
- Autobiography: Mulligan's True Lies and Alibis.
- Awesome Moment of Crowning: They were inducted into the WWE Hall of Fame in 2006.
- Badass Family/Wrestling Family: Two separate families. Mulligan has sons Barry and Kendall Windham, son-in-law Mike Rotunda and grandsons Bray Wyatt and Bo Dallas. Lanza has nephew John Bradshaw Layfield.
- Badass Moustache: Both
- Charlie Brown from Outta Town: Mulligan as Big Machine.
- Dark Is Evil: As heels.
- Everything Is Big in Texas: Mulligan is from Sweetwater. Lanza is from either New Mexico or Laredo.
- Finishing Move: Clawhold
- Generation Xerox: The New Blackjacks, Windham and Bradshaw.
- Nice Hat: Both
- Power Stable: As a team, they were members of The Heenan Family in the WWA in Indianapolis. On his own, Mulligan was a member of The Pringle Dynasty as a heel and Dusty Rhodes' Family as a face.
- Retired Badass: Lanza has worked as a road agent for WWE for years.
- Talk Show with Fists: Mulligan's short-lived "Blackjack's BBQ"
- Underwear of Power
- Wrestling Doesn't Pay: Wrestling cowboys.


text: I've checked in a few changes to allow building TORQUE libs and client commands if the host OS is unsupported. It could use more testing by people that actually want to use Windows, but I've successfully used qstat and qsub under Cygwin! Turns out, it was pretty easy. The only two issues I had were that Cygwin doesn't support getaddrinfo() so the new X11 forwarding code can't be built, and Windows doesn't allow "aux" to be used as a directory name so 'pbs_mkdirs aux' errors are now ignored.


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Cold, wet, sweet — ice cream is an easy slide down the throat whether you've just had your tonsils out or are sweltering on a hot day. One of the hottest months of the year, July, is National Ice Cream Month — a great time to enjoy the cool creaminess of ice cream.
Ice cream has been around almost as long as the pyramids. Alexander the Great enjoyed snow and ice flavored with honey and nectar in 330 B.C. and it was a favored treat during the heyday of the Roman Empire.
In the 13th century, Marco Polo is credited with bringing back to Italy a recipe from the Far East that was much like sherbet and by the 17th century, the English were enjoying "cream ice."
Ice cream came to America as early as 1744. George Washington spent $200 on ice cream during the summer of 1790 trying to keep cool and President Thomas Jefferson had his own recipe for vanilla ice cream.
It was the dessert of the elite and wealthy until 1800 when insulated ice houses were invented. In 1851, Jacob Fussell pioneered the manufacture of ice cream and Americans now have an annual frozen dairy production of 1.6 billion gallons.
During WWII, ice cream was a morale symbol and each branch of the military tried to outdo the others in serving ice cream to the troops. Floating ice cream parlors were built for sailors and Americans celebrated the end of the war and rationing, with ice cream.
The ice cream truck with its cheery jingle and its welcome relief on a hot day has become the stuff of childhood memories. Most of us can remember neighborhood kids hopping barefooted on neighborhood streets, agonizing over whether to buy a Push-up, a Missile or a Fudgesicle.
Ways to Enjoy it
There are myriad ways to enjoy the sweet treat: Scoops of ice cream in waffle cones, sugar cones, or in a cup: sundaes topped with hot fudge, fresh fruit, chopped nuts, flavored syrups; with mix-ins like gummy bears or bits of Oreos; in milkshakes or smoothies; ice cream cakes and parfaits.
Ice cream parlors like Baskin-Robbins and Coldstone Creamery offer a wide variety of flavors and ways to enjoy your favorite summer treat and Baskin-Robbins serves up a Flavor of the Month —in July, it's Oreo 'n Chocolate.
Lactose intolerant or watching calories
Because ice cream is a dairy product made with butterfat, it is often high in fat and calories — but it's so irresistible to most palates that people have found ways to enjoy it anyway.
Soy milk-based ice cream, sherbets and sorbets are available for those who are allergic to dairy products and there are a wealth of sugar-free, low-fat ice cream products in grocery stores for those watching their sugar or calorie intake.
Mountain Democrat staffers did an informal tasting poll of several Skinny Cow low-fat ice cream products: Cookies and Dough Ice Cream Bars (160 calories), Snickerdoodle Ice Cream Sandwiches (140 calories) and Caramel Truffle Ice Cream Bars (100 calories).
Several tastings later, all staffers agreed that the ice cream did not taste low calorie — it was rich tasting, smooth and creamy, just the way it should be and the Cookies and Dough Bars disappeared much too quickly. Even the staffer who doesn't like snickerdoodles liked the Snickerdoodle Ice Cream Sandwich.
Much more tasting needs to be done for a truly objective review.
Celebrate July, National Ice Cream Month and summer with a scoop or two of your favorite ice cream.


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How does a thermometer tell the temperature?
A thermometer measures temperature through a glass tube sealed with mercury that expands or contracts as the temperature rises or falls.
The tiny size of the bulb and micro-fine size of the tube help the mercury reach the temperature of what it is measuring very rapidly.
Bulb thermometers follow the simple principle that liquids change their volumes relative to their temperature. As temperatures rise, the mercury-filled bulb expands into the capillary tube. Its rate of expansion is calibrated on the glass scale. Two different scales can be found on thermometers--the Fahrenheit scale and the Celsius scale.
With the Fahrenheit scale, Daniel Fahrenheit decided that the freezing and boiling points of water would be separated by 180 degrees and he pegged freezing water at 32 degrees. So he made a thermometer, stuck it in freezing water, and marked the level of the mercury on the glass as 32 degrees. Then he stuck the same thermometer in boiling water and marked it 212 degrees. He then put 180 evenly spaced marks between those two points.
In Celsius scale, Anders Celsius decided that the freezing and boiling points of water would be separated by 100 degrees and he made the freezing point of water at 100 degrees. (His scale was later inverted, so the boiling point of water became 100 degrees and the freezing point became 0 degrees.)
Bulb thermometers are most commonly found in two places--outside on our porches measuring the temperatures outside or under our tongues measuring our bodily temperatures.
With the age the technology came the invention of other types of thermometers. Each different type of thermometer has its own distinctive means of measuring or controlling temperature. For instance, bimetallic strip thermometers are extremely effective for controlling temperatures. Although bulb thermometers are good for measuring temperature accurately, they are harder to maintain set temperatures.
While bulb thermometers measure our changing temperatures when we feel feverish, bimetallic strip thermometers help us bake our favorite cakes by maintaining a set temperature in ovens. The bimetallic strip thermometer, because it is made of metal, is good at maintaining the same temperature for a long period of time.
Recent technology has created new ways to measure temperatures with electronics. The most common device is known as a thermoresistor (or thermistor). This sensor changes its resistance with changes in temperature. A computer or other electronic circuit measures the resistance and converts it to a temperature, either to display it or to make decisions about turning something on or off.
The heat is on
The first attempt to make a standard temperature scale was done by Galen in AD 170. In his medical writings, Galen created a standard "neutral" temperature consisting of equal quantities of boiling water and ice. On each side of this "neutral" temperature were four degrees of heat and four degrees of cold.
The earliest devices that were used to measure temperature were referred to as thermoscopes. A thermoscope was a glass bulb with a long tube extending downward into a container of colored water.
Did you know?
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A pair of imposing sandaled feet (see photo at left) greet visitors to the Dallas Museum of Art's current exhibit, The Legacy of the Plumed Serpent in Ancient Mexico. The rest of the Atlantid warrior is missing, but it's not hard to imagine his larger-than-life-sized square, thick body standing guard near the gates of a long lost city or temple.
Quetzalcoatl, the mythical ruler who was driven out of the city of Tula, then wandered throughout the southern part of present-day Mexico, is the inspiration for the exhibit.
According to the DMA's press release for the exhibit, "these rare artworks, which are more than five centuries old, trace the development of an extensive trade network that resulted in a period of international entrepreneurship and innovation that spread across ancient Mexico, the American Southwest, and Central America during the Postclassic (AD 900–1521) and early colonial periods."
While the exhibit is not extensive, what is on display is stunning in scope and layout. The pieces range from the sculpture of a serpent, done in the same, square-like style of the sandaled feet, to delicate pottery used as religious vessels, hammered gold pendants and colorful weavings.
The focus of the exhibit is a book called "codex nuttall," a small volume of symbols painted onto 47 leaves of deerskin that supposedly contains a history of the ancients and their religion. The images are almost too small to see, but an interactive iPad next to the glass-encased book helps the tiny figures stand out.
We went on a Tuesday afternoon. The crowd was light, allowing for easy movement from piece to piece.
Pay close attention to the exquisite mosaic discs scattered throughout the exhibit rooms. While they're not as intricate as those of ancient Rome and Greece, they are impressive. It took several minutes before I realized one of the discs was actually a depiction of seven fierce warriors, delicately laid out in pastel chips of semi-precious stones and twinkling pieces of mica.
For hours/ticketing/parking information, visit the museum's website, www.dm-art.org.
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Unbridled Solutions is an event production and management agency creating transformative experiences. Our people are the core of our values-driven culture. They are the source of our full-service flexibility and innovative creativity.
Browse our current job openings. If you don't see your ideal role, submit your information to our Talent Community to be considered for future positions!


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Man Accused Of Vandalizing Former Faimly Home
Conesus N.Y.-Livingston County Sheriff's deputies have arrested a Livonia man after they say he broke into his families' former house and trashed the place. They say 62 year old Clifford Allison entered the Holmes Hill Road Hone in Conesus and caused extensive damage to the property and removed some property from the house. The house had only recently exchanged ownership from Allison's family to the new owner. He was sent to the Livingston County Jail on 25 hundred dollars bail.


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By Dean Haspiel
I was afforded the opportunity to collaborate with THE DAILY SHOW writer, Elliott Kalan [who recently won an Emmy], and colorist, Giulia Brusco, on a four-page FANTASTIC FOUR story for Marvel Comics' SHAME ITSELF anthology, conceived & edited by Tom Brennan, which parodies Marvel's recent "Fear Itself" crossover event. We're doing a signing for SHAME ITSELF at Jim Hanley's Universe [located at 4 West 33rd street in NYC, across the street from the Empire State Building] from 6-8pm on Weds, Nov. 2nd with local comedians and witty indie/alt cartoonists:
Kurt Braunohler
Elliott Kalan
Victor Varnado
Sara Benincasa
Michael Kupperman
Dean Haspiel
Jacob Chabot
Stephanie Buscema
Tom Brennan
+ More!
For more signing info: http://jhuniverse.blogspot.com/2011/10/huge-shame-itself-signing-at-jhu.html?spref=tw
Written by WYATT CENAC, MICHAEL KUPPERMAN, ELLIOTT KALAN,VICTOR VARNADO & MORE
Penciled by COLLEEN COOVER, DEAN HASPIEL, CLAYTON HENRY & MORE
Cover by SKOTTIE YOUNG
GET READY FOR THE MOST EARTH SHATTERING, WORLD DESTROYING, INSURANCE-RATE HIKING, EVENT IN MARVEL HISTORY SINCE THE LAST ONE! Wyatt Cenac and Elliott Kalan of "The Daily Show" lead a cavalcade of comedy's finest minds to answer the questions about the Marvel Universe you were ashamed to ask! This Fall, the Marvel U will be rocked down to its spandex wearing core! Be ashamed. Be VERY ashamed!
40 PGS./One-Shot/Rated T+ $3.99


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By James Joyce
Vintage Books USA, Paperback, 9780679722762, 816pp.
Publication Date: June 16, 1990
This revised volume follows the complete unabridged text as corrected in 1961. Contains the original foreword by the author and the historic court ruling to remove the federal ban. It also contains page references to the first American edition of 1934.
"Ulysses will immortalize its author with the same certainty that Gargantua immortalized Rabelais, and The Brothers Karamazov immortalized Dostoyevsky.... It comes nearer to being the perfect revelation of a personality than any book in existence."
-The New York Times
"To my mind one of the most significant and beautiful books of our time."
-Gilbert Seldes, in The Nation
"Talk about understanding "feminine psychology"-- I have never read anything to surpass it, and I doubt if I have ever read anything to equal it."
-Arnold Bennett
"In the last pages of the book, Joyce soars to such rhapsodies of beauty as have probably never been equaled in English prose fiction."
-Edmund Wilson, in The New Republic
Today is Bloomsday, the annual celebration of James Joyce's novel Ulysses. The book details an epic day in the life of Leopold Bloom, on June 16, 1904. This year, the commemorations include Twitter, where Joyce fans turned the novel into tweets. More at NPR.org
NPR Audio Player Requires Flash Upgrade: Please upgrade your plug-in to view this content.


text:
michael kors eyewear !If your palms to sweat, had better use across a shoulder bag or purse, and less with the hand bag, otherwise the sweat stains on the bag handle easily U leather is for maintenance?, of course, we know the maintenance way and PU leather to PU leather bags made of how to carry out maintenance, we must first understand what is PU leather, we can better for maintenance, and use our beloved made of PU leather bag. -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Botswana women www.itoeye.co.uk ook - LOVE IT !!!! Lovely looking braclet ,fits nice big enough for a screw driver, spot on :) Was a gift and the recipient was extremely pleased Just took this to a jewellers to get the strap adjusted for my daughter as I bought it for her as a Christmas gift and have been told that the watch is FAKE, NOT HAPPY!! This was a birthday gift for my daughter. The reset on the chronograph did not work. I was dubious about its originality as the instruction booklet Washington michael kors bracelet best kitesurfing .
tories included in this collection are very wonderfully written with none of the latter stories feeling like a repeat from earlier stories. Renae Lucas-Hall, truly does a great job writing all of the stories included in this novel.
I admit, I'm totally obsessed with all things Japan and Japanese culture. Tokyo Tales indulges that obsession for me in written fiction form, and reminded me at times of reading manga and at times of reading an adventure fiction book or Ralph Lauren Outlet n my collection thank you so much <3
So glad you brought this handbag arrived on time a nice size handbag can fit all my stuff in it I'm a huge handbag fan so Iam happy with the purches love the colour would reccomend to a friend wanna buy it in pink next
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I was unsure about this bag because of the colour it was quick delivery and im very happy with this bag it looks better michael kors apparel s what I wanted. Too big as received, requiring links to be removed. Scratched easily, and unfortunately shows marks after first few weeks of wear
I bought this watch for my granddaughter's 21st birthday. .


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PSY at Harvard?
CAMBRIDGE, Mass.
PSY making a visit to chat with students at Harvard University? Even PSY himself says that "is so weird."
The rapper says he spent four years studying management at Boston University, while admiring Harvard from afar.
He joked that his nickname in school was WWF - which he says stands for withdrawal, withdrawal, failure.
A professor of Korean History says PSY was invited on campus as part of a look at him as a modern global digital culture phenomenon.
(Copyright 2013 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.)


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I hated who I was when I became a mother for the first time. I was angry, low, stressed and I did not take care of myself mentally, spiritually or physically. I remember it being tough time for me and my marriage. I had become a negative person and pushed away a lot of family members. I fought with my husband daily. My daughter was born 2 months premature and I think I read too many books that made me paranoid. I hated listening to advice from family members and just wanted to "break free" from … [Read more...]
Cupcakes for Two
April 7, 2014 by Leave a Comment


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Discussion in 'Fan Zone' started by rkell87, Jan 18, 2014.
Anybody else notice there was a significantly less amount of this with the cowboys this year?
not really
no.. I didn't notice that at all
not until week 17
I imagine sometimes KILL, KILL, KILL, means nothing, I also imagine there are other terms used to change a play we're not privy too.
Oh ya....I noticed that. Less audibles @ the line.
I noticed it less this season. But I'm not sure whether there was less of it, or I just got more used to it.
Omaha, Kill.....it's all the same....
I thought you were talking about the visceral reaction cowboy dabs have when they see Jerry or Jason
At least for Eli, Omaha means that the snap count is being reset to that point (after the audible has already taken place). I think with romo, "kill" is the audible to switch to the other play.
I don't think they mean the same thing at all.
Yes, much less this year. More confidence in the Oline to do its job for starters.
I was more referring to them being annoying
are you trying to say that Romo is changing less plays? To be honest I think they just transititioned terms, yeah we used Kill but there where other words check the GB game
I think only the players and coaches know what it really means. They probably have a laugh at people guessing what it means.
I don't really care as long as the play works.
Uh no....
Is this the same as OMAHA! OMAHA! OMAHA!
Yes. Especially in the first half.


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Wanted: Turbo 350 to 205 adaptor
Discussion in 'Parts & Trucks Wanted' started by thebigdaddyof2, Feb 3, 2003.


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- Tautochrone
- Tautochrone Tau"to*chrone, n. [Gr. ?, for ? ? the same + ? time: cf. F. tautochrone.] (Math.) A curved line, such that a heavy body, descending along it by the action of gravity, will always arrive at the lowest point in the same time, wherever in the curve it may begin to fall; as, an inverted cycloid with its base horizontal is a tautochrone. [1913 Webster]
The Collaborative International Dictionary of English. 2000.


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by Staff Writers
Washington DC (AFP) Sep 10, 2011
NASA on Saturday launched a $500 million pair of washing-machine-sized satellites on a mission to map the Moon's inner core for the first time.
The twin spacecraft took off from Florida's Cape Canaveral Air Force Station at 9:08 am (1308 GMT) aboard a Delta II rocket on a three-month journey to the Moon.
"We are on our way, and early indications show everything is looking good," said David Lehman, NASA project manager for GRAIL, which stands for Gravity Recovery and Interior Laboratory.
High upper level winds delayed the first attempt on Thursday, and also briefly set back Saturday's launch.
But once the rocket blasted off, the journey went smoothly and the twins separated as planned just under an hour and half into the flight.
The duo will travel on a three-month route to the Moon, arriving into a polar lunar orbit around New Year's Day.
With one spacecraft trailing the other, the plan is for the two to use gravity tools to map the terrain beneath, revealing the contents of the inner core of the Moon, about which little is known.
The mission should also shed light on the unexplored far side of the Moon, and perhaps tell scientists whether there was once a second Moon that fused with ours.
"GRAIL will be the first mission to determine the internal structure of the Moon," program scientist Bobby Fogel told reporters this week.
"We have used gravity science before to try to gain some insight as to what is going on inside the Moon, however these have been very primitive attempts.
"If those previous attempts could be likened to a magnifying glass, GRAIL by contrast would be a high-powered microscope."
Scientists believe that the Moon was formed when a planet-sized object crashed into the Earth, throwing off a load of material that eventually became what we now recognize as our planet's airless, desolate satellite.
How it heated up over time, creating a magma ocean that later crystallized, remains a mystery, despite 109 past missions to study the Moon since 1959 and the fact that 12 humans have walked on its surface.
A recent hypothesis that there may have been two Moons that slowly merged into one can also be tested with this mission, said principal investigator Maria Zuber.
"If we want to reconstruct the evolution of the Moon over time, we certainly need to reconstruct the temperature structure of the Moon right now," she said.
Little is known for certain about what lies inside the lunar body. The widely held belief that there is a small solid iron core surrounded by a liquid iron core is unproven, said Zuber.
"It is actually quite possible that deep inside the Moon the core could be titanium oxide, which is a material that would have fallen out or would have crystallized out of the magma ocean and sunk to the deep interior of the Moon," she said.
Once the GRAIL twins enter the orbit of the Moon, they will line up with each other and "essentially chase each other around in a polar orbit as the Moon rotates slowly underneath them," said Zuber.
They will hover about 34 miles (55 kilometers) above the lunar surface, with the distance between them ranging from 37 to 140 miles, collecting measurements of the terrain beneath.
The duo will accomplish the mission's primary aim of understanding the Moon's inner character by performing a series of low-altitude gravity field measurements using what is known as a Ka-band ranging instrument.
The mission itself is relatively short in duration, just 90 days once the two spacecraft reach orbit.
About 40 days after their work is done, the pair will plunge into the lunar surface, NASA said. Scientific analysis of their data is expected to continue for a year.
The project is part of NASA's Discovery program, which has launched 10 spacecraft since 1992 to study the solar system.
Last month, NASA launched its billion-dollar solar-powered spacecraft Juno on a five-year journey to Jupiter aiming to discover what makes up the solar system's biggest planet.
After GRAIL, the US space agency plans to launch its Mars Science Laboratory in November on a nearly two-year journey to the red planet.
Related Links
GRAIL at NASA
Mars News and Information at MarsDaily.com
Lunar Dreams and more
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Second bid to launch NASA's Moon-bound spacecraft
Washington (AFP) Sept 8, 2011
NASA will try again Friday to launch a $500 million pair of unmanned spacecraft that will use gravity tools to map the Moon's inner core for the first time, after high winds delayed a first attempt. The GRAIL (Gravity Recovery And Interior Laboratory) mission, aims to launch on a single Delta II rocket as early as 8:33 am (1237 GMT). A second launch window opens at 9:12 am (1316 GMT). We ... read more
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Low Silicon Nodular Pig Iron is used as a high purity furnace addition for the production of Ductile Iron. The Pig Iron contains low levels of carbide stabilisers and an absence of other deleterious trace elements.
12 - 15 Kg Ingots
Bulk via Tipper, Shrink-Wrapped on Pallets, Drums on Pallets