text:
These authors contributed equally to this work.
This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
Severe myocardial dysfunction and tissue damage resulting from ischemia/reperfusion (I/R) is a common clinical scenario in patients with certain types of heart diseases and therapies such as thrombolysis, percutaneous coronary intervention, coronary artery bypass grafting, and cardiac transplantation. The underlining mechanism of endogenous cardiac protection after I/R injury has been a focus of current research. Growing evidences suggests that soluble receptor for advanced glycation end-products (sRAGE) has a cardioprotective effect; however, its role in I/R injury remains unclear. We hypothesized that exogenous administration of sRAGE during hypoxia/reoxygenation (H/R) induces cardioprotection by inhibiting cardiomyocyte apoptosis via multiple signals, involving mitochondrial membrane potential (MMP), the mitochondrial permeability transition pore (mPTP), mitochondrial cytochrome c, caspase-3, Bcl-2 and Bax. Neonatal rat cardiomyocytes underwent hypoxia for 3-h followed by 2-h reoxygenation or were treated with sRAGE for 10 min before H/R. Compared with H/R alone, sRAGE pretreatment reduced H/R-induced cardiomyocyte apoptosis from 27.9% ± 5.9% to 9.4% ± 0.7% (
Ischemic heart disease is one of the main causes of death worldwide, and is considered a global disease burden with the World Health Organization expecting it to surpass infectious diseases and become the leading cause of mortality by 2020 [
Growing evidence suggests that soluble receptor for advanced glycation end-products (sRAGE) most likely protects the heart [
Treatment with H/R reduced the number of viable cells, and sRAGE pre-treatment increased cell viability as determined by the MTT assay. Cell viability in the H/R group accounted for 43.8% of the control group. Compared with the H/R group, sRAGE incubation increased viability from 43.8% ± 10.5% to 96.6% ± 10.1% (
Treatment with H/R increased the amount of cardiomyocyte LDH leakage to 59.6% in comparison with the control group. sRAGE pre-treatment significantly reduced the amount of cardiomyocyte LDH leakage induced by H/R from 159.6% ± 14.7% to 115.6% ± 6.7% (
To determine the effect of sRAGE pretreatment on apoptosis induced by H/R in cultures of neonatal rat cardiac myocytes, we first examined cell morphology by phase-contrast microscopy and nuclear morphology by Hoechst and terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL) staining. Hoechst 33258 staining revealed that control cell nuclei had regular contours and round or elliptical shapes. In contrast, H/R cells showed smaller nuclei and condensed chromatin. Incubation with sRAGE improved morphological features and decreased the number of apoptotic cells induced by H/R. (
Δψm is an important mediator and monitor of key cellular processes. In addition, it is a highly sensitive indicator of the energetic state of mitochondria and the health of cells [
The occurrence and mode of mPTP opening in intact cells was investigated by monitoring the fluorescence of mitochondrial-entrapped calcein with the calcein-AM and CoCl2 co-loading method. Compared with the controls, H/R decreased the fluorescence intensity from 1.36 ± 0.08 to 0.94 ± 0.09 (
In the mitochondria-mediated apoptotic pathway, disruption of Δψm and release of cytochrome c activates a cascade of caspases, including caspase-3, a key and irreversible point in the development of apoptosis. Compared with the controls, H/R induced serious damage to the mitochondrial membranes, resulting in the release of cytochrome c from mitochondria. H/R significantly decreased cytochrome c in the mitochondria by 66% (0.34 ± 0.06,
Compared with the controls, H/R significantly increased the levels of cleaved caspase-3 by 57% (1.57 ± 0.13,
The Bcl-2 family proteins Bax and Bcl-2 play important roles in initiating the mitochondrial death cascade. Western blot analysis was used to investigate the expression of pro-apoptotic Bax and anti-apoptotic Bcl-2 underlying apoptosis reduced by sRAGE. Compared with the control group, H/R significantly increased the ratio of Bax to Bcl-2 by 130% (2.30 ± 0.41,
Neonatal Wistar rats (1–3 days old) were provided by the Animal Department of Capital Medical University. All experiments were performed in accordance with animal protocols approved by the local authorities in Beijing, China. Fetal calf serum (FCS), Dulbecco's modified Eagle's medium (DMEM), and streptomycin/penicillin were from Gibco BRL (Life Technologies, Paisley, UK). Solid-phase extraction (SPE) cartridges (Oasis HLB) were from Waters (Milford, MA, USA). A cytotoxicity detection kit (to measure lactate dehydrogenase [LDH] release) was from Roche (04744934001, CH-4070 Basel, Switzerland). JC-1 and calcein-AM were from Invitrogen (Carlsbad, CA, USA), and CoCl2 was from Sigma (St. Louis, MO, USA). Trizol reagent was from Promega (Madison, WI, USA). sRAGE was from Adipo Bioscience Incorporation(Santa Clara, CA, USA). Anti-β-actin, -GADPH antibody were from Santa Cruz Biotechnology (Santa Cruz, CA, USA). Anti-cytochrome c, -COXIV, -Bax, -BCL-2, and -cleaved caspase-3 antibodies were from Cell Signaling Technology (Danvers, MA, USA). Caspase-9 and caspase-3 activity assay kit were provided by Beyotime Institute of Biotechnology (Nanjing, China). Other chemicals and reagents used were of analytical grade.
The heart of rats were excised, and the ventricular myocardium was cut into small pieces (~2 mm3) in phosphate-buffered saline (PBS) buffered with trypsin (1.125 mg/mL), collagenase I (1 mg/mL) and collagenase II (0.5 mg/mL). Tissue was incubated on a shaker for 20 min at 37 °C with agitation at 100 rpm. Tissue pieces were allowed to settle, and the supernatant containing myocytes was collected, suspended, and centrifuged at 1000 rpm for 10 min. The cell pellet was re-suspended and stored at 37 °C. Cells were then re-suspended in DMEM with 20% (
Cultured neonatal rat cardiomyocytes were randomly divided into the following groups for treatment: Control group (Con): cardiomyocytes were continuously cultured for 5 h without any treatment in normal culture medium; H/R group: cells were subjected to 3 h simulated hypoxia (approximately 2% O2/5% CO2), then 2 h of normoxia (approximately 20% O2/5% CO2) as described [
Cell viability was determined using the 3-(4,5)-dimethylthiazol (-z-yl)-3,5-di-phenytetrazoliumromide (MTT) assay [
LDH kit was used to measure the activity of LDH released into the medium using by an automatic biochemistry analyzer (Roche, 04744934001, CH-4070 Basel, Switzerland) according to the manufacturer's instructions. Briefly, 50 mL of medium and 50 mL of a mix of reagent A and B were co-incubated for 30 min. The absorbance was detected at 492 nm with the use of a spectrophotometer (Labsystems Dragon, Taiwan). Results were demonstrated with 100% in the control group, and that of other cells was expressed as a percentage of the control.
Apoptosis of cardiomyocytes was determined by nuclear staining with the chromatin dye Hoechst 33258 and TUNEL as reported previously [
MMP was estimated by monitoring fluorescence aggregates of JC-1 (tetrachloro-1,1′,3,3′-tetraethyl- 6′,6,5′,5-benzamidazolocarbocyanin iodide), which demonstrated MMP function. The formation of JC-1 aggregates and their fluorescence linearly correspond to increases in membrane potential [
Transient mPTP opening was directly assessed by co-loading cells with calcein-AM and CoCl2 as previously described [
Isolation of mitochondria was performed according to instructions from the Mitochondria/Cytosol Isolation Kit for Cultured Cells. Cells were harvested and homogenized in 1 mL of ice-cold Mito-Cyto Buffer with a Dounce homogenizer. After two centrifugations at 800
Total protein (80 or 100 μg) isolated from neonatal rat cardiomyocytes was separated by SDS-PAGE and blotted onto polyvinylidene difluoride (Hybond ECL, Amersham, USA). Membranes were blocked with 5% (
Caspase activities were determined by a colorimetric assay based on the ability of caspase-3 and caspase-9 to change acetyl-Asp-Glu-Val-Asp p-nitroanilide (Ac-DEVD-pNA) and acetyl-Leu-Glu-His-Asp p-nitroanilide (Ac-LEHD-pNA) into a yellow formazan product (
All values are expressed as the mean ± SD and were analyzed using SPSS v.11.5 (version 11.5; SPSS Inc., Chicago, IL, USA, 2003). Differences between groups were assessed by one-way ANOVA and LSD test. A
sRAGE is the soluble isoform of RAGE that exists in the circulation. RAGE is a 35 kD cell-bound transmembrane receptor of the immunoglobulin superfamily [
sRAGE is a product of both cleavage of the extracellular region of RAGE and the endogenous secreted form of RAGE (esRAGE) [
To gain mechanistic insight into the cardioprotective effects of sRAGE in H/R, we used a cultured neonatal cardiomyocyte model of H/R. Consistent with previous investigations [
Cardiomyocyte apoptosis is one of the major contributors of myocardial injury after I/R. Blocking the apoptosis process could prevent the loss of contractile cells and minimize cardiac injury induced by I/R [
The high-energy demands of cardiac function are supplied by ATP and produced mainly by mitochondria through oxidative phosphorylation, glycolysis and the Krebs cycle [
A diverse array of intrinsic and extrinsic stimuli regulates endothelial cell apoptosis by modulating the balance between the pro-apoptotic caspases and various anti-apoptotic proteins such as Bcl-2. Our results showed that sRAGE significantly inhibited mitochondrial cytochrome c release and caspase-3 and caspase-9 activity following H/R as well as decreased the ratio of Bax to Bcl-2. The effect of sRAGE on caspase-3 in cardiomyocytes was consistent with another study in cardiac microvascular endothelial cells. Yi Liu
Our study revealed that sRAGE induced cardioprotection by inhibiting apoptosis via the mitochondrial pathway in H/R. This cardioprotective effect appeared to involve decreased mPTP opening, attenuation of H/R-mediated mitochondrial cytochrome c release, and reduction of caspase-3 and caspase-9 activity and the ratio of Bax to Bcl-2. Increased sRAGE biosynthesis may contribute to the survival of neonatal rat cardiomyocytes. If confirmed further, the apoptosis-suppressive effect of sRAGE may have important clinical implications during H/R. Modulation of sRAGE biosynthesis may also represent a novel therapeutic strategy for the clinical treatment of H/R.
This work was supported by the National Natural Science Foundation of the People's Republic of China (No. 30801217) and the Beijing Science and Technology New Star Program of the People's Republic of China (No. 2010B050).
The authors declare no conflict of interest.
Cell viability of neonatal rat cardiomyocytes. Cell viability was quantified by the MTT assay. Con, no treatment; H/R, 3-h hypoxia followed by 2-h reoxygenation; H/R- sRAGE, sRAGE for 10 min, then 3-h hypoxia before 2-h reoxygenation; Con-sRAGE, sRAGE alone. Dose of sRAGE was 900 ng/mL. Data are the mean ± SD of optical density from the MTT assay. (*
LDH leakage in medium of cardiomyocytes. LDH content in cell-culture medium was quantified. Con, no treatment; H/R, 3-h hypoxia followed by 2-h reoxygenation; H/R -sRAGE, sRAGE for 10 min, then 3-h hypoxia before 2-h reoxygenation; Con-sRAGE, sRAGE alone. Dose of sRAGE was 900 ng/mL. Data is the mean ± SD (*
Effect of sRAGE on apoptosis. Effect of sRAGE during H/R on apoptosis by Hoechst 33258 (
Effect of sRAGE on mitochondrial membrane potential (Δψm) and mitochondrial permeability transition pore (mPTP) opening. To monitor changes in Δψm (
Effect of sRAGE on mitochondrial cytochrome c leakage. (
Effect of sRAGE on the level of cleaved caspase-3. (
Effect of sRAGE on the ratio of Bax to Bcl-2. (


text:
Beat Feuz collected his first
World Cup win in Kvitfjell.
ell and second for Feuz. Walchhofer called the win"casual," and said the track had been "perfect." Hisskis had just the right bite, and he said he skied in arelaxed, loose manner.While Walchhofer basked in the sunlight, Cuche ap-peared a bit shell-shocked.The other finish significant to deciding World Cuptitles was the 21st-place result of Ivica Kostelic. Hav-ing rejoiced in a January that included seven Cupvictories he was a shoo-in for the crown, but theplacing made it a mathmetical certainty.This left Sunday's super G (March 13), and herethe standings were also sufficiently tight. Six menwere theoretically in the hunt. Georg Streitbergerled the standings, but had succumbed to a leg injuryat Chamonix and was gone for the season. Cucheand Kostelic were tied for second. Walchhofer wasin there, as were Hannes Reichelt and Carlos Janka.Should Cuche have continued to falter he could havefailed to win a title for the first time in five years.He didn't falter, instead displaying the internal re-solve that has formed his stardom. He skied, he said,"with rage in my stomach."He charged the Olympiabakken course, arcing hisway through 42 turns for the win while Austria stackedup four men right (all within 0.44) behind him. Cuchetook the super G lead and would later win the titlewhen that discipline was cancelled at Finals."First of all," he said, "I'm the first one surprised byhow fast I went. Secondly, I've slept only three hoursfor the past two nights. In the afternoons I've spenthours on the phone trying to resolve things thatamount to virtually nothing... namely getting five cen-timeters lobbed off a jump. Thirdly, it's the first time inmy career I'm struggling to appreciate a win."He'll not soon forget the events of Kvitfjell.
SkiRacing.com APRIL 7, 2011 | 19

subset: commoncrawl


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LSU BMC Receives $181,000 Grant for Middle and High School Health Centers
Bogalusa The LSU Bogalusa Medical Center (BMC), in Bogalusa, La., has received a $181,190 grant from the Health Resources Services Administration (HRSA) for its two school-based health centers (SBHC). The grant will allow the Bogalusa Middle School and the Bogalusa High School SBHCs to purchase new equipment, update both health-center facilities and expand healthcare services to the student populations at both schools.
"The school-based health centers are of vital importance to our community," said Senator Ben Nevers. "LSU BMC does a great job keeping our kids healthy and ready to learn."
The two SBHCs treat approximately 900 students each year.
LSU BMC established the Bogalusa High School SBHC in August 1995 and, due to the need in the community, expanded services to Bogalusa Middle School in August 1997.
"The LSU school-based health centers are an integral component of the northshore healthcare system," said Representative Harold Ritchie. "Our children's health would be compromised without the services of the centers."
The SBHCs strive to keep children healthy and in school by providing comprehensive health exams, screenings and crisis counseling.
"The school-based health centers allow us to broaden our reach in the community," said Kurt Scott, LSU BMC hospital administrator. "Our presence in the schools makes healthcare immediately available to children when they need it."


text:
Welcome to 54 Pizza Express!
The original store was established and opened Feb 3, 1988. We started with a very limited menu of pizza, 3 sandwiches choices and drinks. Our goal is to offer a high quality homemade product made with choice meats, cheeses and vegetables served with friendly efficient service, for delivery, pick up or to sit down and eat at the store.
We now have two locations to service the Owensboro area. Over the years we have developed our additional choices of 4 sizes of pizza, over 18 different sandwiches, wonderful calzones, 3 different varieties of bread sticks, 4 different sauces for dipping, 4 different types of pasta, hot wings, 3 different salads, desserts just to name some of the wonderful items we have to offer.


text:
On the Motion to Table S.Amdt. 3667: MOTION TO TABLE DORGAN AMDT NO. 3667; To express the sense of the Senate that a balanced budget constitutional amendment should protect the social security system by excluding the receipts and outlays of the social security trust funds from the budget.
Result: Agreed to (56-43, 1 member not voting, 1/2 threshold)
Details: [click here]
This Month


text:
Dustin Schneider and Toon Van Lankvelt are off to take on the world.
Volleyball Canada made it official Friday by naming the two former Brandon high school stars to the national team for the men's world championship, slated for Aug. 30 to Sept. 21 in Poland. Schneider, a 28-year-old setter and graduate of Brandon's Vincent Massey high school, and Van Lankvelt, a 29-year-old left side from Rivers who graduated from Neelin, were two of the 14 players named to the national team, which headed overseas on Friday.
The Canadian team is training in Poland this weekend before battling the host team in an exhibition match Monday and heads to Finland for two more tune-ups next week.
Canada — ranked 15th in the world — is in Pool C with Bulgaria, China, Egypt, Mexico and Russia and will face the Russians — ranked No.2 in the world — to open the championship on Sept. 1.
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text:
Arizona Latinos leery of ballot delays
Two weeks after the election, the ballots are finally counted in Arizona. The delay — more than half a million were uncounted on Election Day — has left community organizers who registered a record number of Latino voters in Arizona reeling with frustration and suspicion.
A crush of hundreds of thousands of early mail-in ballots received a few days before Election Day is partly to blame for the delay, election officials said. For Instance, Maricopa County recorder's officials were inundated with 200,000 early mail-in ballots just on Election Day. Statewide, more than 600,000 ballots were left uncounted that day — out of about 2.2 million Arizona ballots cast during this year's election.
Still, Latino advocates and leaders remain suspicious and contend election officials should have been prepared for the onslaught. They said they still don't have a clear picture as to why counting took so long and said the delay feeds a perception of discrimination against Latino voters given Arizona's history of intentional voter suppression of minorities. For example, literacy tests were once used to keep Spanish-speakers and Navajos from voting.
"It creates this sense of illegitimacy," said Rodolfo Espino, assistant professor of political science at Arizona State University. "It could be something really innocent going on here, or something really egregious going on here. Regardless, it's a problem that needs to be addressed."
The major source of contention is with the 172,000 provisional ballots cast in this year's election. Most — 122,000 — originated from Maricopa County, the state's largest county and home to about half its population.
Provisional ballots are given to citizens who aren't listed in the election rolls at their polling place. Also, people who were sent a mail-in ballot but decided to vote in person had to use a provisional ballot. This is done to make sure the citizen isn't voting twice.
This year, Latino advocacy groups made a huge push to register Latinos in Maricopa County, enrolling 34,000 who had never voted before.
Many were registered as early mail-in voters.
Other groups also signed up thousands of eligible Latinos to become permanent early voters, meaning they would be sent a mail-in ballot automatically in each election. In 2008, 90,000 Latinos were on the early voting list. This year, it increased to a record 225,000, according to Francisco Heredia, state director for Mi Familia Vota in Arizona.
Now, Latino advocates wonder how many Latinos who received early mail-in ballots were forced to cast provisional ballots, which take longer to verify and tally. Specifically, they want to know how many provisional ballots were given out to voters in precincts in predominantly Latino neighborhoods.
While Secretary of State Ken Bennett said he had met with Latino advocates and planned to gather with other officials to re-evaluate the vote-counting system delays, he said that there was no indication that a certain demographic was treated differently at precincts.


text: KARACHI - Bilawal Bhutto Zardari, patron-in-chief of PPP, has directed the Sindh government to launch relief operations in Thar Desert on immediate basis and form a special relief committee for monitoring.He expressed concern over the deaths of 32 children in Thar due to malnutrition and famine that threatens living beings of the area.In a communication with his Advisor on Minority Affairs Surendar Valasai, who belongs to Thar, Bilawal said he would take up the issue with Sindh Chief Minister Qaim Ali Shah to ensure that Sindh government's relief and rehabilitation efforts could reach out to every nook and corner of the desert."The PPP elected representatives, leaders and workers will fully cooperate with the Sindh government in ameliorating the situation in Thar Desert," he added. He also directed Surendar Valasai to keep him updated in this regard.It is worth mentioning here the drought and starvation were continuously prevailing in Tharparkar that caused the deaths of 32 children. Ignorance of federal and provincial governments over the uncertain situation has forced the residents to migrate while the generation of precious animals is on the verge of elimination. Earlier, the dwellers demanded the authorities to provide them with food on emergency basis to avoid more deaths as further ignorance might bring the human dilemma.Monitoring Desk adds: According to private TV channels, shortage of food and drought has left the Tharparkar people fighting for their lives. The famine is ongoing for the past 3 years in Chachru Tharparkar; and according to Mathi hospital sources, the death toll of starving children has reached to 32 only in the past one month.According to Dr Abdul Jalil Bargari, starvation has caused death of 121 children thus far. Confirming the number of deaths, the health department expressed concerns.At least, six districts of Tharparkar desert have been hit by the famine and drought causing the situation to turn extreme. Meanwhile, no notice by the Sindh government has been taken thus far despite dozens of deaths.It is pertinent to mention here that the Sindh government has dozens of employees dedicated to a number of projects related to food security and crises management with studies sponsored by Asian Development Bank and United Nations.According to Sindh government's finance department's Public Private Partnership (PPP) Unit website, the government lacks wheat storage capacity by 40-50 per cent which causes 'intense' wastage of food.This news was published in The Nation newspaper. Read complete newspaper of 07-Mar-2014 here.


text:
The man was taken from Venice Beach in Los Angeles and later pronounced dead in hospital, the Los Angeles' County Coroner said.
Another 12 beachgoers were treated. Nine of them, including a 15-year-old boy, went to hospitals.
One was in a critical condition, while others were in a "fair" condition, Los Angeles Fire Department spokeswoman Katherine Main said.
Some of the injured were in the water and others on the busy beach's famed boardwalk at the time of the strikes.
The Los Angeles County Sheriff's Department said a fourteenth person was struck on a golf course on Southern California's Catalina Island.
The 57-year-old man is reported to be in a stable condition.
Witnesses described scenes of panic as the sky darkened and lightning erupted shortly afterwards, with thunder and rain.
"You could hear everybody screaming," Angelica Roquemore told the Los Angeles Times.
Stuart Acher said he was struck by lightning while playing volleyball on the beach.
"We went about our game and then all of a sudden, there was a big flash of light and a boom, and it felt like someone punched me in the back of my head," he told local station KABC-TV.
"It went down my whole side of my right body, and my calves sort of locked up, and I fell over.
"And I looked up and everybody else was, you know, falling over."
Roger Davis was quoted by the Los Angeles Times as saying that his house shook and that he heard explosions.
When he ran outside, his neighbour - a doctor - was administering CPR to a victim, he told the paper.
Authorities say the thunderstorms also sparked at least two small grassland fires on the island that were quickly put out.
The unusual weather comes from monsoon moisture that has brought thunderstorms, experts say.


text:
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Jogendranath Banerjee vs Makhan Lal Banerjee And Ors. on 18 December, 1941
Kalyanchand Lalchand vs Sitabai Dhanasa on 5 November, 1913
Krishna Kinkur Roy And Anr. vs Rai Mohun Roy And Anr. on 2 September, 1886
Ganshamdoss Narayandoss vs Gulab Bi Bai on 12 September, 1927
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Central Government Act
Section 187 in The Indian Succession Act, 1925
187. When acceptance of benefit given by Will constitutes election to take under Will.—Acceptance of a benefit given by a Will constitutes an election by the legatee to take under the Will, if he had knowledge of his right to elect and of those circumstances which would influence the judgment of a reasonable man in making an election, or if he waives inquiry into the circumstances. Illustrations
A is owner of an estate called Sultanpur Khurd, and has a life interest in another estate called Sultanpur Buzurg to which upon his death his son B will be absolutely entitled. The Will of A gives the estate of Sultanpur Khurd to B and the estate of Sultanpur Buzurg to C. B, in ignorance of his own right to the estate of Sultanpur Buzurg, allows C to take possession of it, and enters into possession of the estate of Sultanpur Khurd. B has not confirmed the bequest of Sultanpur Buzurg to C.
B, the eldest son of A, is the possessor of an estate called Sultanpur. A bequeaths Sultanpur to C and to B the residue of A's property. B having been informed by A's executors that the residue will amount to 5,000 rupees, allows C to take possession of Sultanpur. He afterwards discovers that the residue does not amount to more than 500 rupees. B has not confirmed the bequest of the estate of Sultanpur to C.


text:
A Trial of Intravenous Denileukin Diftitox in Stage III or IV Ovarian Cancer (ONTAK)
This study has been completed.
Tyler Curiel
Information provided by (Responsible Party):
Tyler Curiel, The University of Texas Health Science Center at San Antonio
ClinicalTrials.gov Identifier:
First received: April 10, 2009
Last updated: January 7, 2013
Last verified: January 2013
- Full Text View
- Tabular View
- Study Results
- Disclaimer
- How to Read a Study Record
This study tests whether denileukin diftitox will deplete regulatory T cells, boost tumor-specific immunity and treat epithelial ovarian cancer in patients who have failed, or who are ineligible for front line therapy.
|Epithelial Ovarian Cancer Extraovarian Peritoneal Cancer Fallopian Tube Carcinoma
|Drug: Ontak
|Phase 2
|Study Type:
|Study Design:
|Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
|Official Title:
|A Phase II Trial of Intravenous Ontak to Treat Epithelial Ovarian Cancer FIGO Stage III or Stage IV, or Extraovarian Peritoneal Carcinoma, of Fallopian Tube Carcinoma Failing or Ineligible for First-Line Therapy
Resource links provided by NLM:
Genetics Home Reference related topics: ovarian cancer
MedlinePlus related topics: Ovarian Cancer
Genetic and Rare Diseases Information Center resources: Ovarian Cancer Ovarian Epithelial Cancer Fallopian Tube CancerU.S. FDA Resources
Further study details as provided by Tyler Curiel, The University of Texas Health Science Center at San Antonio:
Primary Outcome Measures:
- Number of Participants Demonstrating Clinical Response [ Time Frame: 2 years ]Assess the efficacy of Ontak to treat selected advanced-stage ovarian epithelial cancers measured by clinical response rate, disease-free progression, and overall survival.
Secondary Outcome Measures:
- Toxicity [ Time Frame: 3 years ]Determine any toxicity associated with Ontak treatment in these patients.
|Study Start Date:
|February 2007
|Study Completion Date:
|April 2010
|Primary Completion Date:
|April 2010 (Final data collection date for primary outcome measure)
|Assigned Interventions
|Experimental: Ontak
Drug: Ontak
Patients will be treated with Ontak at 12 µg/kg monthly as long as they meet response criteria.
Other Name: Denileukin Diftitox
|Ages Eligible for Study:
|18 Years and older (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Able to provide informed consent
- Not on Immune modulating drugs
- Life expectancy less than 6 months
Exclusion Criteria:
- Unable to tolerate phlebotomy
- Germ cell or stromal cell cancers of the ovaries
- Active autoimmune disease
Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00880360
Please refer to this study by its ClinicalTrials.gov identifier: NCT00880360
|United States, Texas
|CTRC at UTHSCSA
|San Antonio, Texas, United States, 78229
Sponsors and Collaborators
Tyler Curiel
|Principal Investigator:
|Tyler Curiel, MD, PhD
|The University of Texas Health Science Center at San Antonio
More Information
Keywords provided by Tyler Curiel, The University of Texas Health Science Center at San Antonio:
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on July 24, 2017
|Responsible Party:
|Tyler Curiel, Principal Investigator, The University of Texas Health Science Center at San Antonio
|ClinicalTrials.gov Identifier:
|NCT00880360 History of Changes
|Obsolete Identifiers:
|Other Study ID Numbers:
OCR 07-04 ( Other Identifier: UTHSCSA )
|Study First Received:
|April 10, 2009
|Results First Received:
|August 13, 2012
|Last Updated:
|January 7, 2013
Keywords provided by Tyler Curiel, The University of Texas Health Science Center at San Antonio:
Epithelial Ovarian Cancer
FIGO (International Federation of Gynecology and Obstetrics )Stage III or Stage IV
Extraovarian Peritoneal Cancer
Fallopian Tube Carcinoma Failing
Additional relevant MeSH terms:
Ovarian Neoplasms
Neoplasms, Glandular and Epithelial
Fallopian Tube Neoplasms
Neoplasms by Histologic Type
Endocrine Gland Neoplasms
Neoplasms by Site
Ovarian Diseases
Adnexal Diseases
Genital Diseases, Female
Genital Neoplasms, Female
Urogenital Neoplasms
Endocrine System Diseases
Gonadal Disorders
Fallopian Tube Diseases
Denileukin diftitox
Antineoplastic Agents
Analgesics, Non-Narcotic
Sensory System Agents
Peripheral Nervous System Agents
Physiological Effects of Drugs
ClinicalTrials.gov processed this record on July 24, 2017


text:
A lecture on "Crossing Labrador By Canoe: A Journey From the Interior
to the Coast" will kick off the Spring 2001 season of the Natural History
Lecture Series at the University at Albany. The event will be held on
Tuesday, March 13, at 8 p.m. in Lecture Center 7 on the University's
Uptown Campus. All lectures will be held on Tuesday evenings at 8 p.m.
in Lecture Center 7 and are free and open to the public.
Jill Bubier, the Clare Boothe Luce Assistant Professor of Environmental
Studies at Mt. Holyoke College, will be the featured speaker for the
first lecture. She will discuss the route she traveled, including the
De Pas, George and Kogaluk Rivers, and retraces part of Cabot's explorations
in the early 1900s. Her presentation will be illustrated with slides
and commentary on arctic botany.
The six public lectures are sponsored by the University's Atmospheric
Sciences Research Center and the by New York State Department of Environmental
Conservation. The series is now in its 32nd year. Other lectures in
this year's series:
March 20: "New England Forests Through Time -- Insights From
Harvard Forest"
John O'Keefe of Harvard University will review the post-glacial paleoecology
of New England.
March 27: "Snowflake Bentley"
Duncan Blanchard, emeritus professor in the Atmospheric Sciences Research
Center at UAlbany, will discuss Wilson Bentley, who took the world's
first photographs of snowflakes in 1885 and coined the saying that no
two are alike.
April 3: "Coral Evidence for the Interaction Between the Pacific
Tropics and Subtropics on Decadal Time-Scales"
Brad Linsley, professor in the Department of Earth and Atmospheric
Sciences at UAlbany will describe the forensic analysis techniques used
on corals and their interpretative value in assessing global climate
April 17: "Wetlands. Why"
Gary Kleppel, professor in the Department of Biology at UAlbany will
focus on the kinds and roles of wetlands in the U.S. and the research
to understand and protect these valuable ecosystems.
April 24: "Elephant Communication in the Atmosphere"
Michael Garstang of the Department of Environmental Studies at the
University of Virginia, will discuss how elephants use low-frequency
sound to communicate.
For more University at Albany information, visit our World Wide Web
site at http://www.albany.edu.
February 28, 2001
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Berlin (Dec. 20)
German exports of Christmas toys to the United States has been replaced this year by the import of Japanese toys as a result of the Jewish boycott of German goods, the Berliner Tageblatt declared today, disclosing that German toy sales in America are a half million dollars less than last year.
Germany, which formerly occupied first place in American toy imports, the Tageblatt stated, declined from fifty-one percent to thirty-four percent compared to last year. Japanese imports, however, rose from thirty-nine to sixty percent of the entire American import of toys.


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Written on: 07/01/2012 by Nell61 (1 review written)
These are absolutely cr*p. I got loads of spilt ends, when using the wet mode, and it takes far more time than drying first, and then straightening. It's really weird because on my friends hair, the results are really good, and her hair is sleek and shiny, however whe. used on my hair it took me ages and hair was still very damp and curly afterwards. The dry setting of these, however is the opposite. My hair is sleek ish an straight enough, but nothing special. Don't buy.
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During our recent trip through Central Java, we car-pooled with an energetic German couple who shared their intrepid tales of travelling around the World with us. Towards the end of our day together on the harrowing mountain roads of the Dieng Plateau, Daniel made an insightful comment, which I thought, hit the spot for all of us travel addicts.
"Today we learned alot. Now we know more about the Javanese culture, we learned many words in their language like 'makan' (eat), and we experienced the ridiculous way they drive!"
It's the fundamental reason why we just can't stop travelling. On the road, you're constantly taking in new knowledge, always learning about something you'd never known. There is always something new, refreshing and beyond your imagination. It's that element of surprise, sprinkling on you as you uncover a new monument, a new culture, a new dish…
If you're considering quitting your job, slinging on that long-forsaken backpack of yours, it's time to do it! I'm sharing with you some good reasons why we travel:
Learning something new everyday keeps us going to various corners of the World I'd never thought I would ever be. You might be discovering bits and pieces of new knowledge at a time, like the love story of the King who built Taj Mahal, or how 'tapas' were invented, or even tips on how to ride a camel. Life is an endless learning journey.
Finding myself changing psychologically after every single trip gets me yearning for more. Be it a short jaunt or a long trip, I always leave feeling slightly different from who I was. My eyes opened up to a new city and people. A recent short trip to Cambodia opened my eyes to the poverty and consequences of war, and I feeling for the less fortunate more than ever.
Meeting all sorts of people – from fellow travellers to native war victims, there is a life story behind all these faces. I remember meeting an old Chinese lady on a bus ride to Fishermen's Wharf in SF, and ending up touring Chinatown with her. She bought me the best dumplings I've ever had, and told me priceless stories of how she escaped from China to the US, bringing up her son with her bare hands and learning English. Tales like this stay with me forever.
Injecting excitement to an otherwise monotonous life, travelling is our channel of escapism from ordinary life. Friends with a good career slog 9-to-5, and return home to a whole stack of credit card bills and a fat mortgage. We don't own any valuable assets, but in return, we chalk up on our mileage, travel tales to pass on to our children, and good friends from different corners of the world.
Pushing ourselves to the limit gives us the satisfaction we can't get elsewhere. I'm not an athlete and far from being a sports enthusiast, but somehow, bungee-jumping in the midst of a jungle in Thailand and hiking up to the peak of the Aboriginal mountains of Kakadu make me feel proud of who I am.
Feeling unbeatable after conquering countless challenges is an undescribable sensation. There are always ups and downs while on the road – being stuck in a riot, having no clue of the local language and communicating with hand signs, or even getting hypnotized into buying Arabic carpets. Travelling poses one mind-boggling obstacle after another, but once we overcome them, nothing else can stand in our way.
Going through highs and lows with my travel soulmate brings us even closer together. Since we met, we've been on the road together. I'd never met a better travel mate than him, we're opposites but yet have similar interest when travelling. Nothing has made our lives together happier and more colorful than seeing the World together.
Travelling is really addictive. Once you start, you can't stop. When you've seen the Grand Canyon, you wanna see the Andes, and once you've experienced that, you wanna go on to Mount Everest.
What about you? Why do you travel?
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Chairmen's Council Patron
($49,815 tax deductible)
As a patron of the Chairmen's Council, you will be a member of an unprecedented Patron group representative of the ultimate confidence in the mission of MAD. As part of this group you will enjoy all of the benefits of being a Chairmen's Council member as well as:
- Grateful recognition as a Patron on the Chairmen's Council webpage and official letterhead
- Invitation for four to attend the Chairmen's Council annual dinner reception hosted by MAD's Chairmen in a private setting.
- Invitation for four to MAD's Board of Trustees annual dinner
- Dinner for ten and a private tour of the museum with MAD's chief curator
For more information, please contact
Liz Roberts at 212-299-7778 or


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Clinical trials are critical to finding better ways to prevent, diagnose and treat neurological disorders. They help us to move basic scientific research from the laboratory into actual treatments that help patients. Patients coming to UVA can have a better chance of successful treatment because UVA runs and participates in many clinical trials.
Dr. Kenneth Liu is leading a phase II trial for the treatment of vasospasm after stroke using sodium nitrite, building on a promising phase I trial led by our Dr. Ed Oldfield in collaboration with the NIH. Dr. Liu is also leading a trial (SCENT) to evaluate the safety and effectiveness of a new stent in the treatment of aneurysms, and another trial (MISTIE) of minimally invasive surgery with rt-PA to treat intracerebral hemorrhage. Our stroke team, as well as our neuro-oncology and spine teams, are involved in most all major national clinical trials in their subspecialty, giving our patients uncommon access to treatments not available at other regional hospitals. In some cases, we are the only hospital in the state or country with access — indeed, our neurosurgeons have been the only physicians in the country allowed to use nitrite for vasospasm.
Drs. Neal Kassell, Jeff Elias and Jason Sheehan are leading the development of high-intensity focused ultrasound technology, which has exciting potential for drug delivery and to treat tumors, stroke, and movement disorders non-invasively. Dr. Elias's first clinical trial to treat patients with Essential Tremor is believed to have been the first intracranial therapeutic application of the technology in the world, and its favorable results have been published in the New England Journal of Medicine. Dr. Elias is currently enrolling patients in a trial to treat tremor-dominant Parkinson's and multiple other focused ultrasound trials are enrolling or in development.
Frequently Asked Questions about Clinical Trials
Our department chairman Mark Shaffrey is the hands-on medical director of our trials office that also has an administrative director, 5 clinical research coordinators, and several more dedicated support staff. We have recently been conducting or collaborating on new drug and device trials with NIH, the Christopher Reeve Foundation, GE Healthcare, Genentech, Eli Lilly, Johnson & Johnson, AstraZeneca, Novartis, Medtronic, Amgen, and with many smaller companies on the cusp of medical breakthroughs.
You can learn more about all clinical trials being performed by all specialties across UVA at the UVA clinical trials search page.


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COPE Bereavement Support Group - Merrick Jewish Center
Hours: 7-9pm
Ages: AD
225 Fox Blvd. - 516-484-4993
Merrick, NY 11566
Description: COPE, a grief and healing organization dedicated to supporting parents and families living with the loss of a child, holds monthly support groups meetings for parents one Monday of the month for parents on the South Shore. If you are interested in attending or for more information, please call Executive Director Karen Flyer at 516-484-4993.


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Tips for useful posts
January 19, 2012
2 Ideas To Help You Write Great Content Every Day
Jim Connolly
If you have ever wondered, how certain bloggers are able to come up with useful blog posts on a regular basis, this post is just for you. It contains 2 simple ideas, which are used by many of the world's most successful bloggers.
Let's go!
1. Don't let 4 average ideas block 1 useful idea
You get ideas all day every day, things that you could easily turn into an interesting, useful blog post. The challenge is, you probably don't write them down or record them. So, write them down. If you are like me, you will find that most of the ideas are average but maybe 1 in 5 or 1 in 10 are useful enough to be written up into a blog post.
Continue Reading
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Is Google fair? Over the last year, the company's business practices have been put into question after several companies spoke out against it as well as the government investigation of it.
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Now, tell me where it hurts? OK, so I'm not a doctor - actually, with my chronic needle and hospital phobia that was never going to be a career suited to me.
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Finding their pain point and lancing it (urgh, that's just conjured up an awful mental image) is all it takes to get a sale.
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Turning Traffic Into Sales
When it comes to Internet marketing, there are probably more posts written about building traffic, than any other topic. In today's post, I'm going to suggest we focus at least as hard (or harder) on converting targeted traffic...
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When I immersed myself in the social media world three years ago, one of the most remarkable things I noted was how freaking boring it was. There was an almost total lack of any meaningful...
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Earlier this month, we mentioned some of the new Facebook changes including Timeline, Friend groups and a couple tweaks to Facebook advertising. In the past few weeks, Facebook...
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Welcome to our Aladdin's cave of clever and unique corporate gift ideas. At ePromos, we offer the widest range of promotional items designed to help your brand gain extra traction. We stock everything from conventional office accessories to plaques and awards, apparel, sweet treats, and automotive gear. For generous, branded items priced between $20 and $50, explore our selection of custom products guaranteed to please. Our team of experts is ready to go the extra mile and guide you through the process to make sure your final design is flawless!
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Coover, James. Music Publishing: Copyright and Piracy in Victorian England.
Duggan, Mary Kay. Italian Music Incunabula: Printers and Type.
Epstein, Dena J. Music Publishing in Chicago before 1871: The Firm of Root & Cady, 1858-1871.
Fenlon, Iain. Music, Print and Culture in Early Sixteenth-Century Italy.
Hopkinson, Cecil. A Dictionary of Parisian Music Publishers 1700-1950.
Humphries, Charles, and William C. Smith. Music Publishing in the British Isles from the Beginning until the Middle of the Nineteenth Century: A Dictionary of Engravers, Printers, Publishers and Music Sellers, with a Historical Introduction, 2d ed.
Hunter, David. "Music Copyright in Britain."
Krohn, Ernst C. Music Publishing in St. Louis.
Krohn, Ernst C. Music Publishing in the Middle Western States before the Civil War.
Krummel, Donald W. English Music Printing: 1553-1700.
Krummel, Donald W. The Literature of Music Bibliography: An Account of the Writings on the History of Music Printing and Publishing.
Krummel, Donald W, and Stanley Sadie, eds. Music Printing and Publishing.
Lewis, Mary S. Antonio Gardano: Venetian Music Printer 1538-1569: A Descriptive Bibliography and Historical Study, 4 vols.
Twyman, Michael. Early Lithographed Music: A Study Based on the H. Baron Collection.
van Orden, Kate, ed. Music and the Cultures of Print.
Weaver, Robert Lee. A Descriptive Bibliographical Catalog of the Music Printed by Hubert Waelrant and Jan de Laet.
Wolfe, Richard J. Early American Music Engraving and Printing: A History of Music Publishing in America from 1787 to 1825 with Commentary on Earlier and Later Practices.
Coover, James. Music Publishing: Copyright and Piracy in Victorian England. London: Mansell Publishing Limited, 1985. ML 286.9 .M87 1985 (Stacks NOT Music Reference)
Use: Read summaries about music piracy written in English music journals between 1881-1906. Find reference to go to original sources for full article.
Coverage: Articles from the Musical Opinion & Music Trade Review and other English journals of the period that cover copyright and piracy in England between 1881-1906.
Organization: Divided into chapters. Each chapter covers a period of time. The chapter begins with a summary of events for that time period. Then it has summaries of stories appearing in the journals in date order. There is also an introduction, bibliography, and index.
Pros: Has a glossary of main people involved in the piracy and copyright problems in England during this time.
Cons: The journal summaries are a mix of the authors words and the articles, so not completely a primary source.
Duggan, Mary Kay. Italian Music Incunabula: Printers and Type. Berkley and Los Angeles, Calif. and Oxford: University of California Press, 1992. Mus Ref ML 112 .D8 1992
Use: Find information on incunabula (movable type printing music books) in Italy—how it was done, where it was done, and the people that did it. Also a directory of incunabula available in libraries today.
Coverage: Covers
the how, who and where of Italian incunabula during the fifteenth century.
Includes descriptive bibliography of 156 Italian incunabula in nineteen countries
throughout Europe, the United States, and Brazil.
Organization: Divided into three sections and an appendix. Section one is a history of Italian music incunabula. Section two is Italian music type and printers. This section is divided up by city—Rome, Milan, etc. Section three contains a list of original incunabula, information about them, and where they are located. The appendix includes documents relating to Jacomo Ungaro, a nine-page bibliography, glossary, and index.
Pros: Many facsimiles of printed music examples. Not many sources cover this period of music printing. Extensive bibliography.
Cons: Listing on incunabula hard to follow, because there are a lot of abbreviations and the type is very close together.
Epstein, Dena J. Music Publishing in Chicago before 1871: The Firm of Root & Cady, 1858-1871. Detroit Studies in Music Bibliography, ed. Bruno Nettl, no. 14. Detroit, Mich.: Information Coordinators, 1969. Mus Ref ML 112 .E7
Use: Find information about publishing and more specifically the firm of Root & Cady in pre-fire Chicago. Also find lists of sheet music, music books, and music plates printed or used at Root & Cady. Lead advanced researcher to primary sources.
Coverage: Covers Chicago music publisher Root & Cady from 1858-1871. Includes who formed the company, what and how they printed music, and how it came to an end. It also includes a short chapter about other Chicago music publishers during the same time period.
Organization: Divided into six chapters, four appendices, a bibliography, and an index. The chapters are: Chicago Music Publishers Other then Root & Cady, The Partners, Root & Cady Prior to the Civil War, The Civil War Period, The Post-war Years, and The End of the Firm. The appendices contain lists of Root & Cady publications, composer index to sheet music publications, subject index to publications, and a directory of music trade in Chicago.
Pros: Extensive bibliography. Leads researcher to primary source.
Cons: Type set is like a typewriter and hard to read. All references are underlined and make the page cluttered.
Fenlon, Iain. Music, Print and Culture in Early Sixteenth-Century Italy. The Panizzi Lectures 1994. London: The British Library, 1995. Mus Ref ML 112 .F4x 1995
Use: Learn how printing affected music publishing in sixteenth century Italy. Bibliographic sources for further study.
Coverage: Covers growth in the music market—masses, motets, madrigals, and instrumental pieces—in the first half of the sixteenth century in Italy. Excludes theoretical works and liturgical books. Information comes from scholarly magazines, original scores and treatises, and title pages.
Organization: Divided into three sections or lectures. The sections follow Italian printing chronologically. All the bibliographic information is in the footnotes. The appendix lists the items in exhibition that accompanied the lectures.
Pros: Bibliographic references to scholarly articles and original manuscripts and scores.
Cons: No index, the sections do not have titles and it is all in prose, so there are no shortcuts for finding a specific fact.
Hopkinson, Cecil. A Dictionary of Parisian Music Publishers 1700-1950. London: Harding & Curtis Ltd., 1954. Reprinted with new preface by Jacques Barzun. New York: Da Capo Press, 1979. Mus Ref ML 112 .H7 1979
Use: This dictionary helps advanced researchers date eighteenth and nineteenth century French music. Also, includes a brief history of the major French publishers.
Coverage: Music Publishers in Paris from 1700 to 1950. Includes some music merchants and engravers.
Organization: Introduction explaining Paris publishing. Dictionary lists 550 music publishers. Under each publisher is a list of years that something—an advertisement, piece of music, directory, license, etc.--was traced to that publisher. Each date says what source it came from and lists the address of the publisher if it was on the source. For the bigger publishers, there are short histories about the place and its owners. The appendix includes lines of succeeding ownerships of businesses, signboards used by publishers, principle engravers during the eighteenth century, and principle publishers at Lyons in the eighteenth century, and bibliography of works consulted.
Pros: Helps approximate French dates during the eighteenth and nineteenth centuries when French publishers stopped dating music. Follows publishers even when street names and ownership changed. Short histories about the publishers.
Cons: Only includes Paris.
Humphries, Charles, and William C. Smith. Music Publishing in the British Isles from the Beginning until the Middle of the Nineteenth Century: A Dictionary of Engravers, Printers, Publishers and Music Sellers, with a Historical Introduction, 2d ed. New York: Barnes and Noble, 1970. Mus Ref ML 112 .H8 1970
Use: Introduction to British Isle music printing and selling. Find specific names of music publishers and the people involved. Bibliography good for further research.
Coverage: Music publishers, engravers, printers, and sellers in the British Isles from 1500 through 1850. Includes a brief list of instrument makers, and music firms outside of London.
Organization: Divided into four sections. It begins with an historical introduction, followed by a bibliography. The main body of this work is a dictionary of publishers, engravers, printers, and sellers. Each entry includes an address, if applicable, and a sentence or two on what or who they are. The fourth section is a supplement added to the second edition that includes lists of instrument makers, more publisher names, and music firms outside London.
Pros: Supplement adds information unavailable at first publication. Contains a thorough, historical introduction of music publishing and printing in the British Isles.
Hunter, David. "Music Copyright in Britain." Music and Letters 67 (July 1986): 269-282. ML 5 .M64 (Stacks NOT Music Reference)
Use: Research springboard for music copyright practices in early printed music, especially in England.
Coverage: Music copyright in Britain from about 1500-1800. It looks mostly at the laws (or attempts at laws), sale practices and publishers of this time.
Organization: A journal article that follows the copyright story chronologically. The bibliographic references are in the footnotes.
Pros: Short article for the amount of facts and people included in it.
Cons: No index.
Krohn, Ernst C. Music Publishing in St. Louis. Completed and edited by J. Bunker Clark. Bibliographies in American Music, ed. James R. Heintze, no. 11. St. Louis, Mo.: Harmonie Park Press, 1988. Mus Ref ML 112 .K738 1988
Use: Learn about the different St. Louis music publishers and how events of the time affected publishing in St. Louis.
Coverage: Covers major music publishers and some of their works in St. Louis from the early pioneers through about 1970.
Organization: Divided into twenty-one chapters. The chapters flow chronologically. Each chapter is two to fifteen pages long and contains information about a specific publisher, method of publishing, or contemporary event that affected St. Louis publishing. Includes a title index and general index.
Pros: Facsimiles of title pages or advertisements from the different publishers. Contains many bibliographic references. Well organized, with fairly short and easy to read chapters.
Cons: Only two short chapters address publishing in the twentieth century.
Krohn, Ernst C. Music Publishing in the Middle Western States before the Civil War. Detroit Studies in Music Bibliography, no. 23. Detroit, Mich.: Information Coordinators, 1972. Mus Ref ML 112 .K74
Use: Overview music publishing, especially sheet music, in the Midwest before the Civil War. Learn about the important people, publishers, and places. Springboard for further research in Midwest music publishing. Also, good blueprint for regional music publishing studies.
Coverage: The publishing of sheet music in the Midwest from 1800 up to the Civil War. Looks specifically at St. Louis, Cincinnati, Louisville, Detroit, Cleveland, and Chicago.
Organization: Set up like a journal article. Divided into sections. There is an introduction, a section on plate numbers, sections for the cities included, and a conclusion. Each section is prose and the important publications are written into the text.
Pros: Many bibliographic sources. Lays out clear methodology that could be repeated in like projects. Concise.
Cons: No general listing of abbreviations. Each abbreviation is explained in a footnote, and easily overlooked.
Krummel, Donald W. English Music Printing: 1553-1700. Biographical Society Publication for the Year 1971. London: Oxford University Press, 1975. Mus Ref ML 112 .K75
Use: Follow the development of music type--its size, appearance, inking, and it's setting in forms in England from 1533 to 1700. Also learn about the patent laws during this era. Find reference to publishers and printers of that time. Use the bibliography for further research.
Coverage: Covers the patents and forms for music publishing and printing. Follows the development of music type by looking at the publishing of psalm books, part books, song books, engravings, broadside ballads, and song sheets in England from1495-1700.
Organization: Divided into seven chapters, A Successor to Steele; The Politics of the Music Patents; Psalm Books; Part Books; Song Books; Engravings, Broadside Ballads, and Song Sheets; and Some Conclusions. Each chapter has subheadings. Includes a bibliography and index.
Pro: Extensive bibliography. Uses patents and laws of the era to explain more fully the printing and publishing practices.
Krummel, Donald W. The Literature of Music Bibliography: An Account of the Writings on the History of Music Printing and Publishing. Fallen Leaf Reference Books in Music, no. 21. Berkeley, Calif.: Fallen Leaf Press, 1992. Mus Ref ML 112 .K765 1993
Use: Annotated bibliographies for research in music printing and publishing. Also, basic information on topics in music printing and publishing.
Coverage: Selective annotated bibliography of writings about music printing and publishing. Concerned with Western/European printing and publishing since the invention of the printing press. Covers the European languages. Contains both primary and secondary source writings about music printing and publishing, including books, historical or descriptive essays, instructional texts, music type specimens, patent records, exhibition catalogues etc. Excludes lists of musical works, writings on individual printers or publishers writings on performance rights.
Organization: Divided into nine chapters—Theory of Music Bibliography, Historical Surveys of Music Printing, Technology of Music Printing, Music as Graphic Art, Commerce and Property, National Literatures, Institutional Setting, and Reference Works. Each chapter begins with an introduction of the topic. The topic is divided into subtopics that also have a short introduction. The annotated bibliographic references are listed under the subtopics.
Pros: Reference summaries often explain how researcher uses the article. The bibliographic references are organized by use in research, not simply alphabetically ordered. Mentions if source has illustrations or facsimiles. Short introductions to the topic before bibliographies listed.
Cons: Does not include most recent information (1990 forward) on music technology, commerce, and property.
Krummel, Donald W, and Stanley Sadie, eds. Music Printing and Publishing. The Norton/Grove Handbooks in Music. New York and London: W. W. Norton and Company, 1990. Mus Ref ML 112 .M86 1990
Use: Excellent starting point for research in music publishing. Follow the history of music printing and publishing from its beginnings through today. Find personal and business information about music publishers. Includes bibliographic sources for further study.
Coverage: History of music publishing and printing in Europe and the United States from late 1400s through today. Includes music publishers and definitions of printing and publishing vocabulary.
Organization: Four sections. Section one is made up of prose articles divided into two parts—music printing and music publishing. Music printing includes Early Stages and Woodblock Printing, printing Music from Type, Engraving, Lithography, and Music Printing by Computer. Music publishing includes Definitions and Origins, Age of Letterpress, Age of Engraving, Age of Offset Printing, and Music Publishing Today. Section two is a thorough dictionary of music printers and publishers. (A lot of this section is from the New Groves Dictionary of Music and Musicians.) Section three is a glossary of terms relating to music printing and publishing. Section four is a bibliography. The index covers all four sections.
Pros: Includes so many tools necessary for research in one source.
Lewis, Mary S. Antonio Gardano: Venetian Music Printer 1538-1569: A Descriptive Bibliography and Historical Study, 4 vols. (Two volumes in print April 2000.) Garland Reference Library of the Humanities, vol. 718. New York and London: Garland Publishing, 1988. Mus Ref ML 134.5 .G47 L5 1988 vols. 1-2
Use: Learn more about music society, culture, and practices in Venice during the sixteenth century from the standpoint of a music printer. Find specific pieces Gardano published and basic information on music, composers, genres, printing and publishing during this period.
Coverage: Music Antonio Gardano published in Italy--largely Venice--between 1538 and 1559.
Organization: Four volumes. The first three volumes each cover a ten-year span of Gardano's life—1538-1549, 1550-1559, and 1560-1569. Volume one is divided into three sections—The Printer and the Printing House, The Publications, and a Descriptive Bibliography. The appendices include Documents, Primary Sources Cited, Secondary Works Consulted, Short Title Index, Composer Index, Text Incipit Index, Genre Index, Library Index, General Index, and Plates. Volume two is divided into three sections, The Repertory of the 1550s, Notes on the Editions of the 1550s, and Catalogue of Gardano's Publications, 1550-1559. The appendices are largely the same as in the first volume. The third volume will present information like the first two. The forth volume presents a study of Gardano's publishing house, impact of commercialized music printing and musical life in sixteenth-century Europe.
Pros: Lists all primary and secondary sources used. Thorough coverage of Gardano's life and publishing output. Different indexes make searches easier.
Cons: Not completed.
Reviews: Carter, Tim. The Journal of Musicological Research XII/1-2 (March 1992) 117-121; Forney, Kristine K. Journal of the American Musicological Society XLV/2 (summer 1992):332- 38; Hunter, David Chamlers. Notes: Quarterly Journal of the Music Library Association XLVI/2 (December 1989): 380-82; Riva, Federica. Recercare: Rivista per lo studio e la practica della musica antica I (1989) 225- 26.
Twyman, Michael. Early Lithographed Music: A Study Based on the H. Baron Collection. London: Farrand Press, 1996. Mus Ref ML 112 .T97 1996
Use: Learn what lithography is, how lithographs are made, and how to identify lithographs. Find listing of lithographs available in the H. Baron Collection.
Coverage: Covers the history and process of music lithography. Catalogues the H. Baron Collection, made up of nineteenth century, lithographed music from Austria, Belgium, Czech Republic, Denmark, France, Germany, Great Britain, Hungary, India, Italy, Mexico, The Netherlands, Poland, Portugal, Russia, Spain, Sweden, and Switzerland.
Organization: Divided into three sections. The first section explains the history and use of lithographed music in eighteen chapters—each chapter covering specific topics or aspects of lithography. Section two catalogues the H. Baron Collection. It lists all the documents by their country of origin. Part three is seven chapters and teaches how to identify lithographed music. There is also a glossary, bibliography, Index of Publishers and Printers, Index of Composers and Compositions, and a General Index.
Pros: Five pages of bibliographic references. Good footnotes. Lot of facsimiles and illustration. Glossary for lithographed music terms.
van Orden, Kate, ed. Music and the Cultures of Print. With an afterword by Roger Chartier. Vol. 1, Critical and Cultural Musicology. New York and London: Garland Publishing, Inc., 2000. Mus Ref ML 112 .M84 2000
Use: Collection of scholarly essays surrounding the topic of music printing and the cultural implications of the printing of music. Sketches the history of printed music.
Coverage: Covers the time span from 1501 (the advent of music printing) to the early twentieth century (the rise of phonographic recordings).
Organization: Divided into three categories: printing, authorship, and reception.
Pros: Written in narrative fashion. Very current (published in 2000).
Weaver, Robert Lee. A Descriptive Bibliographical Catalog of the Music Printed by Hubert Waelrant and Jan de Laet. Michigan: Harmonie Park Press, 1994. Mus Ref ML 145. W26 B4 1994
Use: Intended for the use of students of the history of printing and for musicologists, but not necessarily will all items be of equal interest to both disciplines.
Coverage: All known music printed by Hubert Waelrant and Jan de Laet identified up to 1994. A catalogue of their publishing output.
Organization: Includes the name of each book or piece of music, a summary of content for each entry, number of pages, kind of type, type style, paper size, watermarks, bindings, and headlines. Reports exact detail for all watermarks and the observation printers employed paper while a book was in press. Includes Waelrant and Laet publications, music printed by Laet and his widow, Waelrant compositions printed by other press, and Waelrant compositions in manuscript sources. Also includes a guide to watermarks, water works, and index of books by short title, index of first lines (in Latin, French, Italian, and Dutch), and an index of composers.
Pros: Extensive coverage. Includes recently found publications. Also includes sketches of watermarks.
Wolfe, Richard J. Early American Music Engraving and Printing: A History of Music Publishing in America from 1787 to 1825 with Commentary on Earlier and Later Practices. Music in American Life. Urbana, Ill.: University of Illinois Press, 1980. Mus Ref ML 112 .W64
Use: Overview music publishing establishing itself in early America. Find names of the people and publishers and their techniques in engraving, printing, publishing, and selling music in the early United States. Learn how to date early music.
Coverage: Covers music publishing—people, process, and marketing--in the United States from 1787-1830. Also includes information on colonial printing practices and innovations and practices after 1830 to a lesser extent.
Organization: Eleven chapters, a three-part appendix, bibliography, and index. The chapters include, Anglo-European Background, Music Publishing in the American Colonies, Printing Music from Type before 1825, Arrival of Musician-Engravers and the Establishment of a Music-Publishing Industry, Early American Music-Publishing Firm, Music Plates, Engraving and Punching Tools, Ink and Paper, The Copperplate or Rolling Press, Customs and Conditions of the Trade, and Dating Early Music. The appendix includes, Account Book of Simeon Wood, Inventory of George E. Blake, and Watermarks in American Music Sheets.
Pros: Good bibliographic references. Facsimiles of original pieces, title pages, or advertisements printed in America.


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A FORMER club football team-mate of Kerry AllIreland-winning captain Liam Hassett was charged this week with breaking into the Hassett family home outside Killorglin on the night of Friday, January 4/Saturday, January 5.
John Houlihan, aged 27, has been charged with the alleged offence and faces seven further burglary charges in the locality over a four-year period. He was arrested on Saturday evening in Kerry Airport as he disembarked a flight from Dublin.
Houlihan, who works as a carer in Killorglin town and gave his address as Douglas, Killorglin, appeared before a special sitting at Killarney courthouse on Monday where Garda Eamon Prendiville said the defendant made no reply to all charges on arrest.
The most recent of the alleged offences concerns the home of Mike Hassett, Glounaguillough, where Mr Houlihan is accused of entering as a trespasser with the intent to commit an arrestable offence sometime between Friday, January 4, and Saturday, January 5.
Similar charges concern the home of Denis Costello, Douglas, between April 8 and April 9, 2012, and the home of Joan Connell, Ballykissane, Killorglin, where Mr Houlihan is accused of entering on two separate occasions between January 1, 2009, and January 1, 2010.
He faces further burglary charges at Gurrane East on December 2 and December 9, 2011; at Tulligmore, Killorglin, on December 22, 2011, and at the home Eve Birdthistle, Valentine Cottage, Douglas, where he is charged with entering through a bathroom window and stealing a black leather handbag containing €300 cash on December 15, 2011.
Inspector Fearghal Patwell said the State consented to bail with strict conditions, including a curfew at his family home in Douglas between 9pm and 8am and that he sign on at Killorglin Garda Station three times per week. The defendant's passport has already been confiscated and he is not allowed to apply for a replacement.
Solicitor Pádraig O'Connell said his client who works as a carer in Killorglin, had co-operated fully with gardaí and will require medical care.
Applying for legal aid, the judge requested that the defendant bring a copy of his Bank of Ireland bank book with him when he returns to the court. In reply to a query from the judge Mr O'Connell added that his client also had an account with Paddy Powers bookmakers and had spent his wages on gambling.
Mr Houlihan is a former Laune Rangers GAA Club player who transferred to Cromane GAA club two years ago. He is a member of Cromane Rowing Club and also coaches the Laune Rangers GAA ladies football team. He is to return to Killorglin District Court on Thursday, February 14.


text: thanks to those who replied to my first post both on list and off it, I enjoyed reading your responses. I suppose deep down I must be a Lord Kelvin man - for those who don't remember the 1890's, he wrote... "When you can measure what you are speaking about, and express it in numbers, you know something about it; but when you cannot measure it, when you cannot express it in numbers, your knowledge is of a meager and unsatisfactory kind: it may be the beginning of knowledge, but you have scarcely, in your thoughts, advanced to the stage of science. " So with this in mind, I put to you the following numbers and observations... a Google search reveals that the term "cyberspace" appears 2.4million times in the online world. Identity appears 14 million times, gender 15 million times, politics 26 million and race 32 million. God appears 64 million times and love gets 119 million mentions - far more important to "cyberspacers" than food, which is only mentioned 86 million times. Interestingly, the internet produces 244 million results, but lags behind good old "sex" with 269 million and business with 266 million.. And at the top of my little list is the search term, "help" which comes in with 301 million results. When I look at the kind of subject matter that appears to be the focus of internet researchers I am dismayed that so much of the intellectual effort seems to be directed at the small end of town. There appears to be an over emphasis upon cyberspace and cyberism, along with identity, gender, race and politics. A search of the titles of the papers presented to last years conference shows that 11 contained the term cyberspace, 32 contained the term identity, 12 contained gender, and 2 contained race - none contained the term "help". The online world, it seems, is screaming out for help - 301million times, yet academia appears to want to talk about minority issues. The online world wants help, sex and business - academia gives it cyberspace and discussion of race, gender and politics. Am I missing something??? Dont you just love numbers :-) see ya Eero Tarik Adelaide, South Australia


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Arbitration has become an increasingly popular alternative to traditional litigation.
This course is taught using a national casebook supplemented with relevant New Mexico case law and statutes. The focus is on domestic rather than international arbitration and voluntary arbitration rather than arbitration compelled by statute.
After a view of the content and relationship of the federal and state arbitration statutes, the course deals with the functional differences between arbitration and litigation, the drafting of arbitration clauses, the enforcement of agreements to arbitrate, the arbitration process, and the scope and limits of judicial review of arbitrator's awards.
At the completion of the course, students will have a firm grasp of the benefits and detriments of arbitration so that they can make sound decisions about whether to agree to arbitration instead of traditional litigation. They also will have an understanding of the tactics and strategy involved in arbitrating disputes successfully.
This course is designed for students who will engage in transactional lawyering (drafting contracts, for example) as well as for those who will represent clients before arbitrators. It is not designed to teach persons how to be arbitrators.


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Hey there, time traveller!
This article was published 26/11/2011 (2067 days ago), so information in it may no longer be current.
BOSTON -- He was a helpful piece to the Boston Bruins Stanley Cup championship last season and he helped dismantle them on Saturday night at TD Garden.
Bruins' centre Rich Peverley, who had two assists in the B's 4-2 victory over the Winnipeg Jets, was a member of the Atlanta Thrashers until just before last season's trade deadline, when he was moved to Boston for current Jets Mark Stuart and Blake Wheeler.
Peverley also has ties to the current Jets coach Claude Noel, for whom he played in the AHL in Milwaukee.
"He's the one who gave me a real opportunity in the American League when I got called up from the ECHL (in 2005)," Peverley said. "I was really thankful to him for that. He played an important part in my career, helped me out a lot.
"He's a really smart coach, very passionate about the game and he doesn't like to lose. He brings a good, winning mentality over there. I congratulated him on getting a chance. I think he deserves it."
Noel said this morning that he rather liked Peverley as a player, even advised the Columbus Blue Jackets, when he was an assistant coach there in 2008, to put in a waiver claim when Nashville had offered him. Atlanta got him and Noel said he believed there were as many as five claims for Peverley.
"I got him in Milwaukee (in 2005) and from the ECHL, so he's come a long way," Noel said. "He was really good, showed a lot of skill, same skill set he has now, only he's matured.
"I'm really happy to see he's turned into a key player."
-- -- --
LEFT-winger Jason Jaffray recorded his first point for the Jets on Saturday night.
He assisted on Dustin Byfuglien's first-period goal, ended up a plus-one in the game and played 8:57.
-- -- --
SHANE Hnidy, the 10-year NHL defenceman who retired this past summer to become a radio analyst on the Jets broadcasts this season, is still well-regarded in Boston.
Saturday, he returned to the city where he won a Stanley Cup last June and had quite an eventful morning on the day of the game.
A posse of reporters descended on the Neepawa native for some reminiscing when he entered the Bruins locker-room for morning interviews.
And some of his former teammates were quick to give him the gears, including Bruins coach Claude Julien.
"The truth or the B.S. that goes with it?" Julien said, asked to voice a comment on Hnidy's time with the Bruins. "He was a really good leader in our dressing room. He had a good voice. Obviously he had a long career because of how hard he competed.
"He was a hard player to play against, honest and at the same time... now here he comes in so I've got be quiet here."
When the laughter subsided, Julien continued. "Last year, same thing in the playoffs, we kept him around the room, did all the warm-ups because we wanted his presence there," he said. "He's moved on and as a rookie media guy he should stay quiet and listen."
Hnidy received a Stanley Cup ring, his summer day with the Stanley Cup but the Bruins did not put his name on the Cup itself because he didn't play enough games after he returned from an injury.


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Christian Ministries at Messiah College
Are you interested in becoming a church pastor? A youth worker? A missionary?
Are you eager to grow and share your own faith but also to understand the faith practices of others around the world?At Messiah College, a nationally ranked Christian college in Pennsylvania, we offer three Christian Ministries concentrations- Congregational Ministries, Cross-cultural Ministries (Missions), and Youth Ministries - as well as a wide range of specialized courses.
Christian ministries major distinctives
As a Christian Ministries major at Messiah College, you'll be able to:
- Dive into foundational Bible and theology courses
- Take an in-depth look at the various Bible texts including Pentateuch, Historical Books, Poetical and Wisdom Literature, Gospels, Paul and His Letter, Revelation
- Sign-up for specialized courses in areas of particular interest to you
- Study abroad and participate in a cross-cultural practicum outside the United States
- Put your classroom knowledge to the test through an internship with one of our many partners, including Young Life and the Mennonite Central Committee
- Immerse yourself in biblical Greek or biblical Hebrew
- Learn about Islam, Buddhism, Judaism, Hinduism and world or non-western Christianity
- Pick up a minor in church music, business, adventure education, counseling, psychology or perhaps Spanish
- Study with professors who publish books and scholarly articles, conduct ongoing research, are nationally recognized as experts in their fields, and lead cross-cultural trips to places like Turkey, Ghana and Kenya
Career options for Christian ministries majors
As a graduate of the Christian ministries program, students are equipped to secure positions in areas such as:
- Youth ministry
- Children's ministry
- Worship ministry
- Missions
- Parachurch work
For more information on career planning for the Christian ministries program, visit the Messiah College Career and Professional Development Center.
Internship opportunities for Christian ministries majors
Messiah's nationally recognized internship program places students in a variety of Christian ministries internships. A few examples include:
- Bethesda Mission
- Camp Hebron
- Camp Hill United Methodist Church
- Christian Life Assembly
- First Church of the Brethren
- Grantham Brethren in Christ Church
- Kenbrook Bible Camp
- Mennonite Central Committee
- New Hope Ministries
- Salt and Light Youth Ministries
- West Shore Evangelical Free Church
- Young Life
Practicing Christian ministry
As a Christian ministries major you'll be required to do field work and a practicum in a local church or ministry setting. And you will also participate in "spiritual formation" (mentoring) groups during your sophomore and senior year as part of the requirements for your Christian ministries degree.
Classroom study
Within the Christian ministries major you will take foundational Bible and theology courses, and take an in-depth look at various Bible texts, including Pentateuch, Historical Books, Poetical and Wisdom Literature, Gospels, Paul and His Letter, and Revelation.
Missions work
If you are interested in missions, there are also many courses available in missions training, world religions and world Christianity.


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I know what you did last weekend- or do I? Introducing mental anchoring to the demand for sport
Football matches are by no means homogenous goods. Rather, there are big differences in single match quality, which is ex-ante unobservable to consumers. We argue that quality uncertainty leads consumers to search for quality proxies which are observable in advance. Aggregate demand functions are shown to depend merely on prices, ex-ante quality perception and stochastic influence factors. Following the work by Kahneman, Tversky and Slovic, we suggest that consumer behaviour is to some extent driven by mental anchoring. Therefore, the usual approach to rely on absolute measures only, seems doubtful. The main focus of our empirical analysis is to introduce relative quality measures, which are based on different anchor levels. Besides seasonal-dynamic and seasonal-RePEc/iso anchors, this specification allows us to include absolute quality proxies as a special case. Applying median regression on a sample from over 2000 individual matches in the German Bundesliga, we find evidence for mental anchoring in the demand for sport. Our results indicate that consumers tend to compare current values for quality proxies to last season's indicator values instead of last match's indicator values.
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References listed on IDEAS
Please report citation or reference errors to , or , if you are the registered author of the cited work, log in to your RePEc Author Service profile, click on "citations" and make appropriate adjustments.:
- David Forrest & Rob Simmons & Stefan Szymanski, 2004. "Broadcasting, Attendance and the Inefficiency of Cartels," Review of Industrial Organization, Springer;The Industrial Organization Society, vol. 24(3), pages 243-265, 05.
- Jeffery Borland, 2003. "Demand for Sport," Oxford Review of Economic Policy, Oxford University Press, vol. 19(4), pages 478-502, Winter.
- Koenker, Roger W & Bassett, Gilbert, Jr, 1978. "Regression Quantiles," Econometrica, Econometric Society, vol. 46(1), pages 33-50, January.
- David Forrest & Robert Simmons & Babatunde Buraimo, 2005.
"Outcome Uncertainty And The Couch Potato Audience,"
Scottish Journal of Political Economy,
Scottish Economic Society, vol. 52(4), pages 641-661, 09.
- B Buraimo & D Forrest & R Simmons, 2004. "Outcome uncertainty and the couch potato audience," Working Papers 542822, Lancaster University Management School, Economics Department.
- Martin B. Schmidt & David J. Berri, 2001. "Competitive Balance and Attendance," Journal of Sports Economics, , vol. 2(2), pages 145-167, May.
- Gärtner, Manfred & Pommerehne, Werner W., 1977. "Der Fußballzuschauer - Ein Homo Oeconomicus?," Discussion Papers, Series I 102, University of Konstanz, Department of Economics.
- Stefan Szymanski, 2003. "The Economic Design of Sporting Contests," Journal of Economic Literature, American Economic Association, vol. 41(4), pages 1137-1187, December.
- Brad R. Humphreys, 2002. "Alternative Measures of Competitive Balance in Sports Leagues," Journal of Sports Economics, , vol. 3(2), pages 133-148, May. Full references (including those not matched with items on IDEAS)
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