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How often do breasts get encapsulated after breast implants? If this were to happen, about how many days or weeks would it be most likely to occur?
What Can Be Done to Prevent Encapsulation from Happening?
Doctor Answers 7
Capsular Contracture Prevention
Capsular contracture can occur on one or both sides, and while it can develop early (weeks) or late (years) after a breast augmentation surgery, in the vast majority of cases it is evident fairly early following the procedure. So the good news is that once you are six to 12 months out from your surgery, if your augmented breasts are soft and supple then they are likely to stay that way for the long term.
It is believed that capsular contracture is primarily a response to the presence of low-virulence or non-virulent bacteria (i.e. not the kind that generally produce an actual infection, with redness/tenderness/fever etc) that adhere to the implant surface on the day of surgery, and which over weeks and months following surgery stimulate the cells that make collagen (called fibroblasts) to make more collagen - thickening the capsule and stimulating it to contract and tighten around the implant. It is not an actual infection; there are no symptoms that this is going on, and taking antibiotics will not prevent the process or reverse it. The source of these non-virulent bacteria is thought to be the patient's skin, or the ductal systems of the breast that lead to the nipple, as both are normally colonized with bacteria.
Because plastic surgeons now have an understanding of some of the reasons why capsular contracture occurs, there are a number of measures, including use of the Keller Funnel, that can be taken to significantly reduce the likelihood that it will happen following breast augmentation surgery
Learn more: http://www.michaellawmd.com/breast-augmentation_breast_implants.html
First, just a bit of terminology. Everyone gets a capsule or 'encapsulation'. The term refers to the normal scar tissue that forms around an implant. Since any scar tissue has the ability to contract (shrink) there is the potential for the capsule to close in on the implant, squeezing it. This capsule 'contracture' can be uncomfortable or possibly affect your shape. In really bad cases it can even become painful. The link below is to a part of my website where many questions about breast implant surgery are answered.
So, capsules happen to all implants...but capsule contractures are somewhat rare. The risk is slightly higher with silicone implants, especially if they're placed over the muscle. When they're under the muscle the risks are not that much different than saline implants. With silicone implants, massaging the breasts seems to reduce the risk although, with implants under the muscle, the muscle is massaging the implants all day long (not the case for over the muscle placement.) So, while massage is very helpful for over the muscle implants, the advantage when they're under the muscle is uncertain- but it couldn't hurt.
Other issues that affect the risk of capsule contracture are linked to techniques used by your surgeon when the implants are placed. This is out of your control. Capsule contractures can really form at any time. I have seen them after only a few months (pretty rare) or years later. Scott Newman, MD FACS
Learn more: http://www.psurgery.com/our-procedures/breast-surgery-doctor-nyc/
Capsular Contracture After Breast Augmentation
The rates of capsular contracture, or scar tissue around breast implants varies from surgeon to surgeon, but really should be about 2-4% across the board. This can happen right after the surgery to years down the line. Anytime you place something foreign in the body, whether it is a knee joint, a pacemaker, or breast implant, etc., your body produces a thin layer of scar tissue in reaction to the device. Most of the time you never know it is there. However, about 2% of women will develop thicker scar tissue that can actually distort the breast, make it firmer, and painful. In general, it comes from either trauma and bleeding during the surgery or immediately afterwards, or the natural bacteria of your body. No one can predict who it happens to or when it will happen. It can be immediately after surgery to years down the line. However, if a patient makes it to the three month mark after surgery and are not having any problems, chances are they will not have to deal with it. I hope this helps.
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All Implants Encapsulate
All breast inplants encapsulate. This is a process in which your body recognizes that the implant is not a normal part of your body and forms a capsule around it. The problem arises when this capsule contracts forming a capsular contracture of which there are 4 grades. Grades 1/2 are not particularly problematic, but grades 3 and 4 contractures cause odd shapes and, often, pain. The best way to avoid a grade 3 or 4 contracture is to select an implant which is not overly large for your breast.
This is a good question; unfortunately there is a lot of disagreement about the right answer. To the best of my knowledge, the rate of encapsulation increases based on the duration of time that the implants are in place. Exact numbers are not known but an estimation might be about 1% of patients per year may develop encapsulation–so, after 20 years you may have about 20% chance of developing encapsulation.
I also think that choice of surgeon, sub muscular placement of implants, massage and/or local or remote infections may be variables to consider.
I hope this helps
Learn more: http://www.poustiplasticsurgery.com/Procedures/procedure_breastaugmentation.htm
Breast "Encapsulation"
The incidence of capsular contracture increases over time, just like the incidence of implant rupture. Older implants have a higher chance of contracture than newer ones. The best data available shows a 15% chance of capsular contracture at seven years after primary augmentation, similar with both gel and saline. This means 85% of women do not get contracture by seven years. More common for patients having reconstruction than augmentation, more common for augmentation-mastopexy than augmentation alone (my empirical observation), and more common if the augmentation is secondary for an initial capsular contracture. Commonly coexists with silicone gel rupture. Most commonly does not occur days or weeks after augmentation, but months or years after.
Learn more: http://feelbeautiful.com
Capsule contracture
The good and bad news, depends on how you look at it, is that you cannot really do anything to cause or prevent it. Much of the potential source of capsule contracture happens during surgery and perhaps genetics/other body factors that you cannot control. Massage may help but there is some disagreement about this. I would not worry about it. The chance of not getting a capsule contracture is in your favor.
All the best,
Dr Repta
Learn more: http://aaaplasticsurgery.com
These answers are for educational purposes and should not be relied upon as a substitute for medical advice you may receive from your physician. If you have a medical emergency, please call 911. These answers do not constitute or initiate a patient/doctor relationship.


text: I've always thought it would be awesome if I could play music and while I walk around my house the music would go with me. It would be nice if when I walk into a room the music would turn on and when i walk out of the room the music would turn off. Im building a house right now so if anyone knows of a system or a mac/iphone app that could do that please post the link or name below.

subset: commoncrawl


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It only takes a minute to get started. Fill out our simple sign up form and login to the site.
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Utilise our website's advanced search to pinpoint members who satisfy your needs. Or just scan through listings and pinpoint singles that you like.
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Mike Rock from Kroenke Sports (April 2010)
Mike Rock, General Manager for Venue Operations at Kroenke Sports Enterprises, came to UNC to speak to the SMRI members and guests from campus. Mr. Rock shared his personal interests in sports and how he started his career in sport venue management as an intern at Candlestick Park in California. He worked his way up the ranks and later moved to Denver to work with the Rockies and the opening of Coors Field. Several students asked Mr. Rock questions pertaining to internships and getting that first job. He had valuable advice for those in attendance and shared the challenges and joys of his job.
Mike Rock from Kroenke Sports


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She is the new beauty queen of Dhanbad, er, Asia.
Coal capitals very own bahu Ashwini Rohit Lala has made the town proud, bringing home the Mrs Asia International 2014 title.
Representing India at the finale in Kuala Lumpur, Malaysia between June 25 and 29, Ashwini proved that winning a beauty pageant went beyond flaunting a washboard tummy in teeny-weeny bikinis.
Pipping 26 other contestants from Asian countries, Ashwini, who is a former corporate honcho, awed her judges and audience at Kuala Lumpurs PRGM auditorium with her comely combination of beauty and brains.
Ashwini, felicitated in Dhanbad on Tuesday evening, thanked her husband, in-laws, parents and friends for her win. Asked how she won the coveted crown, Ashwini said she aced the last question.
She was asked a formidable googly who would she choose between her mother and husband.
An unfazed Ashwini smartly said both. Explaining her stand, the Dhanbad bahu impressed judges when she articulated the contributions of her loving mother and supportive husband.
Her answer, which combined the best of head and heart, made her husband Rohit, a Dhanbad-based entrepreneur, proud. He and their two sons Ayushman and Aryaman had attended the pageant.
Recounting her tour, Lala said contestants went for interviews, grooming sessions and rehearsals. In between, organisers took the women to Malacca City, about 300km from Kuala Lumpur, to show Malaysias cultural heritage.
On the final day, contestants were judged on looks, fitness, know-how, social work, personality and articulation.
Ashwini, who qualified as an electronics engineer from Pune University and went on to do an MBA from Canada, worked with MNCs like CocaCola before her marriage to Dhanbad entrepreneur Rohit.
Now, shes an organic farmer, using five acres that belong to her father-in-law Deepak Lala, also a leading businessman of Dhanbad. A hands-on mother, she also helps her husband in his business.
Asked what the win means, she said: I have more responsibilities. I want to inspire other women to be fit, confident and work for the needy.


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Aligning Strings
You want to align a string, left, right, or center. You might use this when generating reports, for example.
The easiest solution is to use the string module, which solves the left and right padding issues.
1> io:fwrite("|~s|~s|~n", [ string:left("Title",20), string:right("Price",10) ]). |Title | Price| ok 2> io:fwrite("|~s|~n", [ string:centre("Fabulous", 25) ]). | Fabulous | ok
left and right both default to using '$ ' (the space character) as the padding character; you may override this by providing the character in the third argument. The left and right functions also truncate the string if it's longer than the specified field width, but centre generates an error in that case.
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As Brad Paisley and LL Cool J know all too well, everybody makes a bad call sometimes.
Nicki Minaj first came under fire yesterday for her incendiary, expletive-littered new track "Lookin Ass N—-," but it was the song's cover art that really set people off. The image (above) features a famous photograph of civil-rights icon Malcolm X wielding an AK-47 and looking worried,with the track's already-divisive title slapped on — and that set everybody off.
After inciting multiple Change.org petitions and widespread criticism, Minaj issued a lengthy apology — attached to an Instragram photo of her wielding a gun.
Read the full text below:
What seems to be the issue now? Do you have a problem with me referring to the people Malcolm X was ready to pull his gun out on as Lookin Ass Niggaz? Well, I apologize. That was never the official artwork nor is this an official single. This is a conversation. Not a single. I am in the video shooting at Lookin Ass Niggaz and there happened to be an iconic photo of Malcolm X ready to do the same thing for what he believed in!!!! It is in no way to undermine his efforts and legacy. I apologize to the Malcolm X estate if the meaning of the photo was misconstrued. The word "nigga" causes so much debate in our community while the "nigga" behavior gets praised and worship. Let's not. Apologies again to his family. I have nothing but respect an adoration for u. The photo was removed hours ago. Thank you
I'm afraid to ask, but reader, what do you think? Whatever it is, maybe just think about it for another minute before you get all comment crazy.


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missing translation for 'onlineSavingsMsg'
Learn More
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OHAUS™ Defender 3000 Bench Scales
Economical and versatile scale weighs up to 600 lb. (300kg) with 1:6000-7500d resolution.
Manufacturer: OHAUS™ 83998116
Includes: AC adapter, RS-232 cable, painted Carbon Steel frame, tubular painted Steel column, externally visible level bubble and adjustable Rubber leveling feet with locking nuts
SpecificationsDescription & Specifications
Scale; Bench; Defender 3000; Capacity: 600 lb. (300kg); Readability: 0.1 lb. (0.05kg); Stainless steel pan; Painted carbon steel frame; Aluminum IP67 load cell; With RS232; Multiple weighing modes
- 304 stainless steel pan with painted carbon steel frame and aluminum IP67 load cell
- Adjustable nonslip rubber leveling feet with external level indicator
- T31P with ABS housing or T31XW with IP66 stainless-steel housing
- Multiple weighing units include lb., oz., lb:oz, kg, g
- Parts counting mode with selectable sample sizes, last sample size and Average Piece Weight data
- One 25mm-high LCD weight display with high-contrast backlight
- Built-in RS232 for printing and data connection
- AC adapter and internal rechargeable lead acid battery
Service Plan
Service agreement available.
|100 hr.
|Span 5kg or 5 lb. to 100% of capacity, user selectable
|600 lb., 300000g
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|5.8 in.
|ABS Plastic, Stainless Steel, Aluminum
|14 to 104°F
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|AC adapter, painted Carbon Steel frame, 27.36 in. tubular painted Steel column, externally visible level bubble and adjustable Rubber leveling feet with locking nuts
|Internal rechargeable Lead Acid battery
|600 lb.
|ISO 9001:2008, EMC: EN60950, EN61326, FCC Class A, CE, cULus
|25.59 in.
|<2 sec.
|-10 to 40°C
|Defender™ 3000 bench scale


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The Meadow House is a house we love because it provides a calm, comfortable, and restorative sanctuary from the often chaotic lives of a scientist/ statistician and an avid bird enthusiast. They commissioned the home as the fulfillment of a dream. The well-traveled couple wanted a calm place to read and write, in a reflective, inspiring coastal setting. An inviting courtyard separates the main living spaces from a two-story volume that houses sleeping and bathing quarters. The massing creates a sheltered outdoor space and focal point, blocking both coastal winds and neighbors. Indoor and outdoor connections are emphasized by the continuous use of stone from the front walk through the house and out to the central courtyard. The plan is open and informal, with warm interiors and generous windows framing the ocean and forested ridge. The material palette draws from these views. The polished concrete floors are cast with local beach sand, and the fir used throughout was locally harvested. Being in the main living space is to dwell "in the meadow"—able to observe the birds and native plants close at hand, a perfect counterpoint to the couple's hi-rise apartment in San Francisco.
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To make an insect symmetrical (the way Dr. Ashe likes them!) I use a
method comparable to the way tissue is traditionally used.
I decide where the center of my specimen is going to be and drag
a vertical guideline onto my drawing. I use the Scissor
Tool to cut all of the lines apart at that guideline (figure A).
Next ...
Create another layer. This is where to use a black line to draw
over your two superimposed halves, finding the mean (figure C).
• Hide the
two layers with the colored lines.
• Select the remaining (black) lines.
• Copy them.
• Paste in Front (command-F).
• Once more, reflect the lines horizontally using the guideline as
axis (figure D).
In a separate Illustrator file
I use my other sketches as templates for drawing the legs, antennae, and
I copy the resulting drawings into the file I've done for the
Making the original full-body template visible again, I size and arrange
these parts on one half of the body (figure E). Once I have them
placed just so, I copy and reflect them over to the other side (figure
I find it works best in Photoshop (the next step) to select all
the finished lines and make them about 0.35 points in thickness.
The line drawing is now ready to be opened in Photoshop for finishing.
previous | next
• Acknowledgements
Habitus Drawing • Photo
Illustration • Structural
Drawing • Definitions
All images ©2004 The University of Kansas
This site last updated July 21, 2004.


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Katie Price Launching Her Book 'In The Name Of Love' at Worx Studios
Where's the video of this stunt?
Horse must have been hypnotized/medicated/ejaculated right before performance to insure compliance with Big Boobs.
I'm tired of these historical revisionist fantasy novels. That outfit barely looks Russian, and I'm pretty sure Catherine the Great never hung out on the beach.
So she fucks the horse "in the name of love"? I don't get it…


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Hello Kitty Themed Meat Bun Almost Too Cute to be Eaten
Hello Kitty as we know, is an animated cartoon cat famous in Japan and around the world. Apart from the many Hello Kitty themed merchandise, here's one that's edible. A Hello Kitty-themed meat bun from Japan.
This Hello Kitty meat bun, or nikuman in Japanese has been given a second appearance this time around, following its surprise last year. The bun more or less will just taste like a meat bun, but certainly a nice experience for Hello Kitty fans if they have a chance to get it, since the meat buns are only available in limited quantities on sale from 16 October 2012 onwards at Circle K Sankus convenience stores in Japan.
What's really cute is to see a bunch of them sitting around in the steamer eagerly waiting for customers to try them out.
An interesting and somewhat-cute looking meat bun, Hello Kitty style.


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Police: Baby Dead After Minneapolis Father Punches Baby for Making NoiseA Minneapolis man is now behind bars after authorities say he punched his 4-month-old daughter in the face because she was making too much noise.
Police Shooting During Traffic Stop Leaves Minnesota Man DeadA 32-year-old man has died after an officer-involved shooting Wednesday night in the St. Paul suburb of Falcon Heights, authorities say.
Warrant: Minnesota Doctor Saw Prince, Prescribed Drugs A Minnesota doctor saw Prince twice in the month before his death — including the day before he died — and prescribed him medication, according to contents of a search warrant that were revealed Tuesday as authorities returned to the musician's suburban Minneapolis estate as part of their investigation into what killed him.
Death Raises Questions: Did Prince Die of An Overdose?Prince's final days and unexpected death at age 57 raise questions among experts familiar with prescription painkiller overdoses. It's possible the innovative musician's demise represents one of the most public tragedies in an overdose crisis now gripping America.
Complete City Guide To Minneapolis, MinnesotaMake plans to go explore Minneapolis, Minnesota. There, you can enjoy everything from fine dining to theater venues and museums to the great outdoors.
48 Hours In Minnesota's Twin CitiesTravel guide for visitors who only have 48 hours to visit Minnesota's Twin Cities of Minneapolis and St. Paul
Top Fishing Destinations In The USA look at five of the best fishing destinations in America.
Preview: 2014 MLB All-Star GameThe Athletics have some incentive for an AL victory in the All-Star game; since 2003, the winner's league gets to start the World Series at home, and 23 of the last 28 titles were won by teams scheduled to host four of a possible seven games.
Best Cities For Black Friday ShoppingWhile many other consumers will simply avoid holiday crowds at shopping malls or even wait until Cyber Monday, retail stores across the nation will be buzzing with activity on the day after Thanksgiving. The following are five of the best American cities for Black Friday deals.
Md. Uses New Technology To Keep Drivers SafeNew technology designed to keep drivers safe by spotting weak bridges could be installed on Maryland roadways soon.
Texas Man Sentenced For Hacking Of NASA, BusinessA Texas man has been sentenced for hacking into the computer systems of a Minnesota company and NASA's Goddard Space Flight Center in Maryland.
WEATHER BLOG: What A Storm!This storm has been pounding a lot of the country with everything from mountain snows across the west to a full out blizzard in the Upper Midwest to icing in the Appalachians and flurries even down in Georgia, to severe weather along the Gulf.


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Summer 2016
Dear Parents,
We have brought another academic year to a close. We marked this occasion with field trips, a moving up luncheon for our future 6th and 7th grade students, and concluded with our end of the year liturgy planned by our 6th grade and celebrated by Fr. Gustav Miracle. It is a time to reflect on accomplishments and challenges.
Click here to continue!


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Sorry, the DVD that you are looking for is not available right now.
We did a search for other DVDs with a similar title, however there were no matches. You can try selecting from a similar category, or use the search box above to find your DVD.
German naval officer Karl Ehrlich loves his country but hates Hitler. Busted to the command of a lowly freighter docked in Australia as World War II erupts, Ehrlich must choose: be interned by the British or sail to Germany so his men can determine their own fates. On a foggy night, Ehrlich decides - and casts off!John Wayne as Ehrlich and Lana Turner as a woman forced into Nazi espionage are a formidable romantic team in this harrowing adventure directed by John Farrow (Wake Island, Hondo). Through a relentless high-seas pursuit, Ehrlich drives his exhausted men (James Arness, Tab Hunter and others). The pursuing British have the navy that rules the waves. The freighter Ergenstrasse has the Duke. Any action fan knows that's an even - and exciting match!
Barcode: 9325336025475
Classification: PG (Low level violence)
Encoding: PAL
Format: DVD
Language: English
Number of Discs: 1
Region: 4 (Australia & New Zealand)
Released: 7th October 2015
Running Time: 117.0 mins
Subtitles: English, Italian, English for the Hearing Impaired, French, Dutch, Arabic


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Ask a Lawyer and Get Answers to Your Legal Questions
Thank you for your reply. I think I could be terminated for an attendance issue I have been having. I was given the opportunity to work 32 hours per week at the beginning of the year to assist my Mother after my Father fell and broke both hips in late November 2012. Aside from three days that I had to be off work (one for a kidney stone); one for a migraine and another to assist my Mother, I've been working for at least 31 hours. I was off work on Weds. thru Friday last week because I had a migraine and felt very stressed because my Father has been moved into long term care. I called my agency on Wednesday morning and told my supervisor there that I was having family issues and he said he would talk to the company I work for. He called me back a few hours later and said that the company supervisor said that I can work for 32 hours for the next three weeks but beginning May 1, I have to be able to commit to 40 hours per week. I told my agency supervisor that not only am I dealing with major family issues, but I also have bipolar. He didn't say anything in response to that. I felt even more stressed after that and made an appointment to see my psychiatrist the next day (Thursday) and was given a doctor's excuse to be off last Thursday and Friday. I sent the doctor's excuse to the agency and to my supervisors via email last Thursday and haven't heard anything back as to whether it was received and whether I should return to the job tomorrow. I don't want to be met with my desk contents at the door tomorrow.


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Wolverhampton Wanderers vs Manchester City play live football England Premier league match on 22 April 2012 at Molineux Stadium (Wolverhampton, West Midlands). this big and though match for both teams we will provide Wolves vs Man City live score online match highlights goals videos results team news head to head games previews at here on asportsnews page.
Wolverhampton Wanderers (Wolves) good team to play football and manage team players at match situation. they face this week Man City team in Premier League match.Wolves goalkeeper Dorus de Vries is poised to make his first Premier League start for the club in place of the injured Wayne Hennessey. On-loan defender Sebastien Bassong is available after serving a one-game ban, while winger Matt Jarvis could be restored to the side. Wolves goalkeeper Dorus de Vries is poised to make his first Barclays Premier League start for the club against Manchester City at Molineux on Sunday.
Manchester City (Man City) also good in game.they have a best players squad to get take all points this match.they are in form and mostly chance this time beat Wolves with big margin.Manchester City are close to their best again, whacking 10 goals past West Brom and Norwich in the space of a few days, whilst Wolves are in a horrible spiral which is only taking them one way.
Wolves vs Man City Live Football Score Premier League Highlights Goals Videos Results Online
Wolves vs Manchester City Live EPL 2012.
England Premier League – EPL 2012
Date:- 22 April 2012 | Time:- 11:00 am
Venue:- Molineux Stadium (Wolverhampton, West Midlands).
Striker Mario Balotelli is Manchester City's only absentee for Sunday's Barclays Premier League trip to Wolves.The Italian misses the trip as he completes a three-match ban for his sending off in the defeat at Arsenal a fortnight ago. Manager Roberto Mancini reports no other injury concerns with Yaya Toure having made a successful return from a knee injury against Norwich last week.Wolves have lost their past eight home games, the second worst run in Premier League history after Sunderland (10) in 2002-03 and 2005-06.
Wolves vs Man City Live Match Squads Players List:
Wolves Players Lin-up Provisional squad: De Vries, Ikeme, Zubar, Foley, Bassong, Stearman, Johnson, Berra, Ward, Kightly, Henry, Davis, Milijas, Edwards, Jarvis, Doyle, Ebanks-Blake, Fletcher, Jonsson, Gorman, Price, Forde.
Manchester City Players Line-up Provisional squad: Hart, Pantilimon, Richards, Zabaleta, Lescott, K Toure, Savic, Kompany, Clichy, Kolarov, Nasri, Milner, Johnson, Y Toure, Barry, Pizarro, De Jong, Silva, Aguero, Tevez, Dzeko.
Wolves vs Man City Live Score Online Premier League Match Highlights Videos 22 April 2012:
Manchester City will play Wolves (Wolverhampton Wanderers) live soccer/football Premier League match at their home ground on 22-04-2012.this game Wolves has home ground and home crowed advantage to take lead. watch Wolves vs Man City live score online match highlights goals videos results at here on match times.stay here for live actions previews.


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Violet L (Novak) Ivan
Funeral Service
Violet L. Ivan, age 87 of Batavia, formerly of Chicago, passed away Tuesday, February 19, 2013 at Delnor Hospital in Geneva surrounded by family.
She was born November 16, 1925 in Chicago, Illinois, the only child of Frank and MaryAnn (Radostits) Novak.
Throughout her life, Violet found incredible joy in the time she spent with her family and close friends. She will be greatly missed by all those whose lives she touched.
She is survived by her children Susan Marie (Steven) Sage of Colorado and John (Micheline) Ivan of Batavia; grandchildren Emilee and Ethan; and goddaughter Janet (Vincent) Fiorito of Westchester; and many dear friends.
Violet was preceded in death by her husband of 47 years, Albert Frank Ivan and her parents.
A visitation will be held Friday, February 22, 2013 from 4:00 pm until the time of the funeral service at 7:00 pm at Malone Funeral Home 324 East State Street (Route 38), Geneva.
Burial will be held privately.
Memorials in lieu of flowers to Mooseheart Child City and School, Moose Charities 155 South International Drive, Mooseheart, Illinois 60539 or American Cancer Society 143 First Street, Batavia, Illinois 60510 would be appreciated.
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Hey, friends and new visitors! Today's the day I've been looking forward to since the calendar switched over to 2016. My friend Stephanie of Casa Watkins rounded up 10 other talented bloggers to participate in the first ever New Year New Room Challenge. We're all going to do a room refresh in just three weeks, so on January 26th you'll get to see 11 makeovers at once. Woohoo!
I know that completed room makeovers are your favorite kind of posts around here, so I love having an extra kick in my pants to get this room finished sooner rather than later. (If you're inclined to play along and zhush up a space in your own home, share it on Instagram or Facebook using #NewYearNewRoomChallenge. We'll be reposting our favorites!) Now that the logistics are out of the way, let's talk about the space in question–the back entryway.
The door directly in front of you leads to the garage, so this is where we toss bags, backpacks, and shoes. You may remember I moved this open storage shelf out of the laundry room to create space for the folding table. (And since case goods here never say die, it's now on the back porch to begin its umpteenth incarnation, this time as a potting bench.)
This is the view from the kitchen, and straight ahead is the pantry door. To the left are the french doors that open into the ladies' lounge.
Here's the view from the lounge showing how the pantry door relates to the garage door. The photo below was taken from the same spot looking towards the right. The archway leads back into the kitchen and ahead is the garage door.
That corner is where I thought we'd place a built-in unit. When we first moved here, I priced one out and it was over $2,500.00. After that disappointing (and not happening) quote, I put this room on the back-burner for nearly a year and a half. Since we're not 100% committed to staying in this house forever, I decided a portable (and significantly cheaper) mudroom was the way to go. Here's the design plan.
I knew January would be the perfect month to finally order the locker unit I'd been stalking, since that's when companies typically place organizational items on sale. It was 25% off with free shipping, plus I had Christmas money burning a hole in my pocket. I don't love the shutter panels so we're covering them with some wood panels painted to match.
The walls are now painted the same custom mix from Sherwin-Williams that I used in the laundry room, and we're going to carry it over into the kitchen and living room. (Not me, though. I'm hiring someone for such a large job.) The doors are going to be painted Tricorn Black to add drama and contrast to the room and (more importantly) showcase the new mirror that will be installed between the two doors.
The mirror has the antique look I was going for and looks way more expensive than its price tag of just under $100.00. Lamps Plus is one of the very generous sponsors I'm working with on this makeover, so I was able to add a light fixture to the plan as well. Just yesterday, I received some crushing news about the selected fixture–it's on back order until mid February. Dun, dun, dun!
We all know it's on back order because it's beautiful, affordable, and has clean and classic lines. Undeterred, I selected this fixture, which isn't available in gold, but I still really like the shape and the glass. (Guess who's got a hot date with a can of spray paint?)
Shorty's bowls have been replaced with the world's cutest dog dishes, which is only fitting since he's (duh) the world's cutest dog.
My dear friend and her family dog-sit Shorty for us since he hates going to the kennel. (Spoiled much?) She commented to me when I picked him up how unattractive his bowls were and that she'd flipped them over to see where the ugly came from, which of course is where she spied my name carved in the bottom. We have an entire collection of bowls that are more accurately described as hot-mess dog dishes from my failed pottery endeavors. Just because you really, really love something doesn't mean you're going to be good at it, kids. #truth
Minted saved the day again by supplying me with a pair of prints framed in brass from California artist Jaime Derringer. (I'll explain a little bit more about how I selected the art pieces in next week's progress post.)
And because I know how much you all live for my poorly edited room mock-ups, here you go! (Apologies to the new people here–the regulars truly, truly love these. No, truly.)
I'll have lots more details to share next week about the design process and how we may have (ahem) needed to remove the pantry door to saw off the bottom half-inch so it could clear the new rugs, along with a Pinterest fail regarding the Est. 1999 sign. The road to a finished room is never smooth and easy, amiright?
Many thanks to the companies that are sponsoring the New Year New Room Challenge. I couldn't fit all of the wonderful products available to us in my 7 x 7 room, but I still want to show some sponsor love.
Be sure to go check out what the other ladies are up to! This is truly a whirlwind project, so today is the first time I'm seeing all of the other plans, too.
Thanks so much for reading, and I hope you have a great day!


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This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
The design, development and clinical success of HIV protease inhibitors represent one of the most remarkable achievements of molecular medicine. This review describes all nine currently available FDA-approved protease inhibitors, discusses their pharmacokinetic properties, off-target activities, side-effects, and resistance profiles. The compounds in the various stages of clinical development are also introduced, as well as alternative approaches, aiming at other functional domains of HIV PR. The potential of these novel compounds to open new way to the rational drug design of human viruses is critically assessed.
APV ----- Amprenavir
ATV ----- Atazanavir
BCV ----- Brecanavir
BID ----- twice per day
CYP450 ----- Cytochrome P450/3A4
DRV ----- Darunavir
FDA ----- Food and Drug Administration
FPV, fAPV ----- Fosamprenavir
HAART ----- Highly active antiretroviral therapy
IDV ----- ndinavir
Kd ----- Dissociation constant
Ki ----- Inhibition constant
LPV ----- Lopinavir
NFV ----- Nelfinavir
PIs ----- Protease inhibitors
PR ----- Protease
q24h ----- every 24 hours
RTV ----- Ritonavir
SQV ----- Saquinavir
TPV ----- Tipranavir
The aspartic protease of human immunodeficiency virus (HIV PR) is responsible for the cleavage of the viral Gag and Gag-Pol polyprotein precursors into mature, functional viral enzymes and structural proteins. This process, called viral maturation, which leads to the final morphological rearrangements, is indispensable for production of infectious viral particles [
Although the success of HIV PIs has been remarkable and there are not fewer than nine of these compounds currently approved by the FDA as antiviral agents, for several reasons both the academia as well as the industry need to continue in their effort to develop novel, more potent compounds.
First, there is a problem of antiviral drug resistance. The high mutation rate caused by the lack of proofreading activity of the viral reverse transcriptase, the dynamic viral replication in HIV-positive individuals, together with potential dual infection and insufficient effect of drugs lead to rapid selection of viral species resistant to the currently used inhibitors. The pattern of mutations associated with the viral resistance is extremely complex (
Trends in annual rates of death due to 7 leading causes among persons 25-44 years old in the United States during period 1987-2004. Dramatic decrease in the rate of death due to AIDS coincides with the introduction of HIV protease inhibitors (source: National Vital Statistics, Centers for Disease Control and Prevention, Atlanta).
Secondly, the clinical use of PIs is further affected by their high price and by problems of tolerability, toxicity, and adherence. Before the introduction of the first PIs into the clinical practice, optimistic expectations prevailed that the toxicity of this class of virostatics will be low because of the absence of enzymes similar to HIV protease in the human body. Unfortunately, the reality was different, and soon it turned out that compounds can interact with other molecules, particularly in the lipid metabolism and trafficking pathways. Consequently, the side effects of PIs are very frequent and often so serious that the drug toxicity may sometimes represent even a greater risk for patients than the HIV infection itself [
Taken together, inspite of the indisputeble success of the HAART and benefit to patients, new approaches to the antiviral treatment, including novel HIV PIs, are highly desirable to achieve better control of HIV infection while maintaining acceptable quality of patient's life. Novel PIs should be developed with broad specificity against PI-resistant HIV mutants, better pharmacokinetic properties, lower toxicity, and simple dosage.
In the following contribution, we will briefly review the PIs that are currently used clinically, and we will also mention some other compounds that entered various stages of clinical testing. Subsequently, we will provide an overview of selected experimental HIV PIs targeting the enzyme active site as well as other functionally important regions, namely the protease dimerization and flap domains.
The three-dimensional crystal structure of HIV PR dimer depicting mutations associated with resistance to clinically used protease inhibitors [
Mutations in the protease gene associated with resistance to PIs a.
|Major mutationsc
|Minor mutationsd
|Atazanavir +/- ritonavir
|50, 84, 88
|10, 16, 20, 24, 32, 33, 34, 36, 46, 48, 53, 54, 60, 62, 64, 71, 73, 82, 85, 90, 93
|50, 54, 76, 84
|11, 32, 33, 47, 74, 89
|50, 84
|10, 32, 46, 47, 54, 73, 76, 82, 90
|46, 82, 84
|10, 20, 24, 32, 36, 54, 71, 73, 76, 77, 90
|32, 47, 82
|10, 20, 24, 33, 46, 50, 53, 54, 63, 71, 73, 76, 84, 90
|30, 90
|10, 36, 46, 71, 77, 82, 84, 88
|48, 90
|10, 24, 54, 62, 71, 73, 77, 82, 84
|33, 47, 58, 74, 82, 84
|10, 13, 20, 35, 36, 43, 46, 54, 69, 83, 90
a Adapted from International AIDS society reports [7]
b Ritonavir is not listed separately as it is currently used only as a pharmacologic booster of other PIs (in low dose).
c Major mutations are those selected first in the presence of the drug or those substantially reducing drug susceptibility.
d Minor mutations emerge later and do not have a substantial effect on virus phenotype. They may improve replication capacity of viruses containing major mutations.
e PIs used in co-formulation with ritonavir.
Since the identification of HIV as an etiological entity of AIDS, more than twenty different drugs have been introduced into the clinical practice. Such drugs inhibit specific steps in viral lifecycle and thus the replication of the virus. In fact, more virostatics are available for HIV/AIDS than for all other viruses combined. This exciting endeavor has been extensively reviewed [
Nine protease inhibitors are currently on the market (see
Overview of the inhibitors of HIV protease approved for clinical use with their dosage, side effects, and the position in the present therapeutic arsenal, elaborated with regard to the recommendations of the US Department of Health and Human Services [Panel on Antiretroviral Guidelines for Adults and Adolescents. Guidelines for the use of antiretroviral agents in HIV-1-Infected adults and adolescents. Department of Health and Human Services. November 3, 2008; 1-139. Available online: http://www.aidsinfo.nih.gov/ContentFiles/AdultandAdolescentGL.pdf. (Accessed 12 September 2009)]
|Generic name and abbreviation
|Commonly recommended dosage
|Most common side effects and off-target activities
|Position in the present therapeutic arsenal
|Ritonavir (RTV)a
|100–200 mg p.o. BID as pharmacokinetic booster of various PIs (original pharmacodynamic dose was 600 mg p.o. BID)
|nausea, diarrhea, abdomenalgia, hyperlipidemia, lipodystrophy syndrome, inhibition of the cytochrome P450 3A4
|practically only pharmacoenhancing of various PIs
|Saquinavir (SQV)
|1000 mg + RTV 100 mg p.o. BID
|diarrhea, hyperlipidemia, lipodystrophy syndrome
|second-line HAART therapy
|Indinavir (IDV)
|800 mg + RTV 100 mg p.o. BID
|nephrolithiasis, lipodystrophy syndrome, hyperlipideamia, hepatotoxicity
|second/third-line HAART therapy in case of resistance or intolerance
|Nelfinavir (NFV)
|1250 mg p.o. BID
|diarrhea, hyperlipidemia, lipodystrophy syndrome
|second/third-line HAART therapy in case of resistance or intolerance, approved for therapy of children
|Lopinavir (LPV/r) b
|400 mg + RTV 100 mg p.o. BID
|diarrhea, hyperlipideamia, lipodystrophy syndrome
|first line option for PI based HAART regimen
|Amprenavir (APV)
|600 mg + RTV 100 mg p.o. BID
|diarrhea, toxoallergic rash, hyperlipidemia, lipodystrophy syndrome
|replaced by its prodrug fos-amprenavir
|Generic name and abbreviation
|Commonly recommended dosage
|Most common side effects and off-target activities
|Position in the present therapeutic arsenal
|Ritonavir (RTV)a
|100–200 mg p.o. BID as pharmacokinetic booster of various PIs (original pharmacodynamic dose was 600 mg p.o. BID)
|nausea, diarrhea, abdomenalgia, hyperlipidemia, lipodystrophy syndrome, inhibition of the cytochrome P450 3A4
|practically only pharmacoenhancing of various PIs
|Saquinavir (SQV)
|1000 mg + RTV 100 mg p.o. BID
|diarrhea, hyperlipidemia,lipodystrophy syndrome
|second-line HAART therapy
|Indinavir (IDV)
|800 mg + RTV 100 mg p.o. BID
|nephrolithiasis, lipodystrophy syndrome, hyperlipideamia, hepatotoxicity
|second/third-line HAART therapy in case of resistance or intolerance
|Nelfinavir (NFV)
|1250 mg p.o. BID
|diarrhea, hyperlipidemia, lipodystrophy syndrome
|second/third-line HAART therapy in case of resistance or intolerance, approved for therapy of children
|Lopinavir (LPV/r) b
|400 mg + RTV 100 mg p.o. BID
|diarrhea, hyperlipideamia, lipodystrophy syndrome
|first line option for PI based HAART regimen
|Amprenavir (APV)
|600 mg + RTV 100 mg p.o. BID
|diarrhea, toxoallergic rash, hyperlipidemia, lipodystrophy syndrome
|replaced by its prodrug fos-amprenavir
Abbreviations: BID ----- twice per day, q24h ----- every 24 hours
a Ritonavir is at present used in therapy of HIV infection practically only as a pharmacokinetic booster.
b Lopinavir is marketed by the manufacturer only as (Kaletra © ), in co-formulation together with low doses of ritonavir which acts as a pharmacokinetic booster
All PIs in current clinical practice have been approved only for oral administration, but their absorption in the gastrointestinal tract and diffusion through anatomical barriers is usually poor to moderate. This effect is partly due to their extensive binding to plasma proteins (90–99%), partly due to the binding to P-glycoprotein and consequent eflux of the drug [
On the other hand, any co-administration of these "boosters" with drugs metabolized by cytochrome P450 isoenzyme 3A4 may be problematic and lead to severe side-effects. There have been reports on serious and even life-threatening events following co-administration of PIs with hypolipidemics (HMG-coA reductase inhibitors), antihistamines, or ergot alkaloids. Numerous other drugs, such as, e.g., sildenafil, corticosteroids, or psychotropic agents [
The design of the first protease inhibitor
Typical primary resistance-conferring mutations selected under the pressure of SQV are G48V or L90M. The most common adverse reactions reported in patients receiving SQV were gastrointestinal disturbances, such as diarrhea, nausea, or abdominal discomfort [
RTV inhibits both HIV-1 and HIV-2 proteases.
The first protease inhibitor which could be used by adults as well as by children was
In order to further improve the safety, pharmacokinetics, and therapeutic potency of amprenavir,
Chemical structures of the first generation HIV protease inhibitors.
The second generation inhibitors were designed to inhibit HIV PR species resistant to the inhibitors of the first generation and to introduce well tolerated drugs with minimized side effects and simple once-daily dosing, which may improve patients´ adherence to the treatment.
At present, Kaletra® is the first choice PI for an initial antiretroviral regimen. The development of resistance is associated with accumulation of mutations occurring at nine to eleven positions ("lopinavir mutation score") [
The structure-based design of
A unique compound was designed at Pharmacia & Upjohn and later introduced by Boehringer-Ingelheim.
The most recently (2006) approved nonpeptidic HIV protease inhibitor is
Even though DRV is chemically related to APV, it binds nearly 100 times more tightly than APV and 1,000 times more tightly than SQV, IDV, RTV and NFV to the wild-type HIV-1 protease [
The high genetic barrier to the development of resistance, its better clinical efficacy against multidrug-resistant HIV variants together with favorable tolerability, safety, and once-daily regime, make DRV one of the preferred therapeutic option both for drug-naïve and for highly treatment-experienced patients. DRV is generally well tolerated, but the main adverse effects are common with the other members of the class, such as gastrointestinal symptoms and lipid abnormalities [
Chemical structures of the second generation HIV protease inhibitors
Some other interesting compounds were recently or are now in various stages of clinical trials. The often convoluted history behind the development of individual compounds documents the complex requirements for the activity, resistance profile, toxicity, pharmacokinetics, and drug interactions, as well as fierce competition in the field.
A structure-based approach at Sequoia Pharmaceuticals, Inc. involved identification of a substructure of conserved regions in the PR active site and the design of compounds that would make optimal interactions with such a conserved substructure. The aim was to design compounds retaining high potency against a variety of PI-resistant HIV strains. This effort lead to discovery of
Chemical structures of inhibitors HIV protease in the pipeline.
Generally, the design of novel HIV PIs includes efforts to minimize the inhibitor molecular weight, maximize its interactions with the backbone of the PR binding cleft while maintaining flexibility for better fit to the variable binding clefts of PR resistant species [
The variability of structural motifs used by rational design or selected by library or combinatorial screening is enormous, and it is beyond the scope of this review to attempt to cover all promising compounds reported up to date. Below we will only mention several interesting recent examples, thus exemplifying the variability of approaches and of the resulting chemical structures. Even though it is questionable whether any of these compounds will ever enter the market, they still represent important contributions to the armamentarium of modern medicinal chemistry.
Favourable properties of darunavir lead to the development of several follow-up compounds, exemplified by
A very attractive class of compounds, cyclic ureas, was introduced in 1994 by Lam
Chemical structure of DMP450 (
In order to enlarge the chemical space available for the design of novel anti HIV molecules, several groups used unusual chemistry for the identification of HIV PIs. Surprisingly, even inorganic compounds,
Crystal structure of metallacarborane inhibitor bound to HIV PR.
In order to rationalize the design of new generation PIs, Schiffer and coworkers introduced an interesting approach (recently reviewed in [
Several HIV PR regions have been identified that seem to be conserved in all examined HIV sequences derived from treatment-naïve patients. They include residues 1-9 and 94-99 (N- and C- termini), 21-32 (active site core), 47-56 (flap region) and 78-88 (substrate-binding region) [
HIV PR is only active as a dimer in which each of the two catalytic aspartates is contributed by one monomer. The determination of the dimer dissociation constant (Kd)has been the goal of considerable efforts of many groups, but its value differs substantially depending on the various techniques and experimental conditions (reviewed in [
Early studies demonstrated that interface peptides reproducing the native sequence of C-terminal and N-terminal fragments act as HIV PR dimerization inhibitors, although in micromolar concentration [
Modification of the termini of an interfacial peptide by attachment of a lipophilic group and alkyl chains (e.g., palmitoyl)
Interesting macromolecular inhibitors targeting dimerization domains are fusions of the N-terminal HIV-1 PR peptide with a cell permeable domain from HIV-1 Tat [
There has been a significant effort to develop dimerization inhibitors of HIV PR and characterize their binding on a structural level [
Residues 43-58 of HIV PR form an anti-parallel β-hairpin referred to as "the flap". Two flaps within a dimer cover the active site cavity and their movement is crucial for binding and release of protease substrate. The conformation behavior of this glycine rich region has been extensively studied [
Recent examples of inhibitors targeting the open-flap conformation are
The region preceding the flap in the sequence (residues 34-42) is called the flap elbow (or the hinge). It folds into a surface exposed loop with no particular secondary structure which undergoes substantial change during flap opening and closing (
A monoclonal antibody recognizing an epitope corresponding to residues 36-46 inhibits the activity of HIV PR with Ki value in a nanomolar range [
HIV PR flap conformations.
Development and clinical application of specific inhibitors of HIV PR almost immediately after the identification of HIV PR as a valid pharmaceutical target represents fascinating and, indeed, probably the most successful example of rational drug design in the history of biomedicine. There are currently nine FDA approved PIs available. In developed countries the protease inhibitors have at present time a secure position in the therapeutic armamentarium for both the initial therapy and the second-line and salvage treatment. It is also highly probable, that they will keep this position with further development of new more effective and less toxic molecules in the future [
There is continuous need for the development of safer, cheaper drugs, active against the host of multi-resistant HIV species stemming from different virus strains, with high antiviral activity, excellent pharmacokinetic properties and little off-target activity, imposing low pill burden and little side-effect to the patient. Even if such an ideal drug never materializes, the research on HIV PR and its inhibition will continue to provide remarkable wealth of information about ligand-enzyme and protein-protein interactions, structural plasticity of proteins, mechanism of resistance development, pharmacokinetics of a chemotherapeutic in individual compartments of the body,
The authors thank Devon Maloy for critical proofreading of the manuscript, Milan Kožíšek for help with the preparation of figures and numerous colleagues (namely Ron M. Kagan, Tomas Cihlar, Sergei Gulnik and Alex Wlodawer) for sharing unpublished information and very useful critical comments. The research on HIV protease inhibition and structure in the laboratory of J.K. and P.R. is funded by Ministry of Education of the Czech Republic under program 1M0508, by the Grant Agency of the Academy of Science of the Czech Republic (IAAX00320901) and by the 6th Framework of the European Union (HIV PI resistance, contract No. 03769).


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For snakes, hunting bats in a cave is like shooting fish in a barrel
When the sun goes down in the subtropical forests of Puerto Rico, hundreds of thousands of bats emerge from the caves that stud the island's northern end. After a day of sleeping, the animals are ready for a hard day's night of hunting insects. For some of them, though, there will be no feast of beetles and mosquitos, and they'll instead wind up a meal themselves for the snakes that have set up an ambush at the cave's entrance.
After providing a warm, safe place to sleep all day, the caves become death traps once darkness falls. Puerto Rican boas slither in from all over the forest to turn the bats' exodus into their own hunting ground. At the mouth of the caves, they lay on the ground, cling to roots and vines on the walls or hang down from the ceiling, their tails finding footing in the tiniest cracks and crevices. As the bats flit past them on all sides, the snakes wait, swinging like clock pendulums. When a bat brushes by or collides with a snake's head, the snake grab it in its jaws, squeeze it in its coils and eats it whole.
The nightly ritual is played out on its largest scale at La Cueva de Los Culebrones, or the Cave of the Long Snakes. The cave's estimated 300,000 bats can empty out in as little as three hours, providing the boas with an all-you-can-eat bat buffet. Biologists observers have seen as many as 20 boas hanging around the cave entrance, grabbing all the bats as they care to and chowing down.
Even with the steady stream of food flying right into their mouths, the snakes can be picky, and competitive. Several species of bats can inhabit the same cave, and the smaller ones tend to exit first. Although the snakes are in position and waiting as soon as the first bats, they often wait half an hour to an hour to start hunting, when the larger bat species take flight. This might be a strategic choice to save their energy for prey that gives them more calories in reward for their effort.
Sometimes, a snake that's not having any luck with its own hunting will attempt to steal a bat from another snake. On one occasion, a biologist watched three snakes fight over a large bat carcass for over an hour and a half. By the end of it, the snakes were exhausted and the bat went uneaten.
Last summer, Neil Losin and Nate Dappen, a pair of biologists and filmmakers who run Day's Edge Productions, were in Puerto Rico and heard stories about the snakes, and had to see and film it for themselves. The resulting video, Snakes in a Cave, is awesome, and captures some closeup, slow motion bat snatching action.
Snakes in a Cave from Day's Edge Productions on Vimeo.
Reference: Rodriguez-Duran, A. (1996). Foraging Ecology of the Puerto Rican Boa (Epicrates inornatus): Bat Predation, Carrion Feeding, and Piracy Journal of Herpetology, 30 (4) DOI: 10.2307/1565698


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Well, that time of year is here. The time for all those look-back posts in pretty much every major blog, and even if we're not that big, we decided to give it a try. The next two weeks will be filled with some of the best interactive maps, visualizations and infographics that came to our attention, starting today.
In this post, we'll be focusing, of course, in interactive maps. New and creative ways to tell stories using maps as a core element, or services and web apps that were featured on this weekly space. Because this list was prepared on top of those weekly round-ups, it's only natural that we've left some other great maps behind. Therefore, feel free to add your suggestion in the comments, or share it with us on Twitter.
Finally, before we move on to the first part of the top 100 interactive maps featured on Digital Cartography in 2013, we'd like to thank you all that have been following, sharing and submitting your works to us. That's what really drive us, believe it.
And here's the first set of picks:
Sandy and the Buildings of New York City | IDV Solutions
The economic impact of the MWC on Barcelona | BBVA
The landscape of Computer Science professional development | University of Chicago
Climate Commons | Earth Journalism Network
Wikipedia Recent Changes Map | Stephen LaPorte, Mahmoud Hashemi
History of San Francisco Place Names | Noah Veltman
Where the blasts occurred | Boston Globe
Metropolitain | Dataveyes
America's deadly tornadoes | NewScientist
A Twisting History: Tornadoes in the U.S. | The Wall Street Journal
A city's Heartbeat | Max Xu, Adrian Vu, Zi Xin Chong
Twitter's languages of New York | James Cheshire, Ed Manley and Oliver O'Brien
The last three months on Foursquare | Foursquare
Warming World | New Scientist
A New Age of Exploration | National Geographic
American Homes Through the Decades | Trulia
L.A. street quality grades | LA Times
Chesapeake Bay Grasses | Stamen
The Global Transition to a New Economy | New Economics Institute
Homicides in the District | The Washington Post
Philadelphia Homicides 2006-2012 | Mark Headd
The state of the Swiss forest | National Forest Inventory
Map of the Dead | Doejo
The Geography of Hate | Floating Sheep
Timelapse | Google
Cicada Tracker | Radio Lab
Swarmageddon: America's periodical cicadas | New Scientist
A Century of Cicadas | The New York Times
The incredible rise of migrants' remittances | Tages Woche
World's most extraordinary species mapped for the first time | The Guardian
Assessing the Damage Along the Tornado's Path in Oklahoma | The New York Times
How Safe Is Your Hospital? | Kuow
Android Errors in Real Time | Bug Sense
Sea of Steel | The Washington Post
America's deadly tornadoes | NewScientis
Charting Syria's civil war | NewScientist
Mon Quartier
History of Australian bushfires | The Guardian
Split country: Dunkin' vs. Starbucks | Boston.com
Adapting to Climate Change | WWF
A month of Citi Bike | The New Yorker
US Import and Export Tourism data | PackerShack
State of the OpenStreetMap | MapBox
Global Peace Index | Vision of Humanity
Data Paris
New Maps and a New Plan for New York | ProPublica
Wikipedia Worldview
Sub-national conflicts in Asia from 1947 to 2010 | The Asia Foundation
MBTA Bus Speeds | bostonography.com
Amsterdam Campus | Jan Willem Tulp
That's it for today's selection. Don't miss the second part, next week, with more interactive maps that stood-out in 2013!


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| 2002N-0278 - Prior Notice of Imported Food Under the Public Health Security and Bioterrorism Preparedness and Response Act of 2002; Reopening of Comment Period
|FDA Comment Number :
|Submitter :
|Mr. Dave Baglein
|Date & Time:
|05/17/2004 06:05:21
|Organization :
|Hoyt Shepston and Sciaroni Inc.
|Private Industry
|Category :
|Issue Areas/Comments
| The Prior Notice requirements of the Bioterrorism Act are not working on the FDA side nor on the side of filers nationwide. FDA is currently unable to notify filers when there are data errors that will result in penalties once FDA begins implementation of Phase Four on August 14,2004. The lack fof information available to filers regarding the nature and scope of errors does not bode well for the flow of legitimate trade in the near future. According to FDA redcords,over 50% of currrent Prior Notice transmissions are inaccurate of inadequate. Because the system is clearly not working,we request that Phase Four impelemention scheduled for Aug. 13,2004, be moved back to at least 6 months to enable both FDA and entry filers to receive proper training. The Act was made into law to protect our food supply. As it stands now,it will not protect our food supply but will surely result in the refusal of large amount of legitimate importations and in the unfair assessments of penalties against law abiding importers and entry filers.
We request that Phase Four implementation fo FDA Prior Notice requirement be postponed for six months.


text: I just found my jobs. They all ran properly but where sent to /var/spool/torque/undelivered. I guess I need to setup stagein and stageout etc. ~Lawrence _____ From: Kevin Van Workum [mailto:vanw at tticluster.com] Sent: Wednesday, February 07, 2007 11:58 AM To: Lawrence Sorrillo Cc: torqueusers at supercluster.org Subject: Re: [torqueusers] Error adding a node did you restart maui? On 2/7/07, Lawrence Sorrillo <sorrillo at jlab.org> wrote: Hi: I have a working version of Maui-3.2.6p19 and torque-2.1.6. Initially I had one machine running pbs_server and pms_mom. Everything worked well! Now I am attempting to add a dual process machine to the list of compute nodes. Below is the sequence of events I adhered to: 1. Installed pbs_mom on the compute node. 2. Edit /var/spool/torque/mom_priv/config to include the $clienthost host_running_pbs_server 3. Start pbs_mom on the compute node. 4. run qmgr -c 'create node compute_node np=2' 5. now pbsnodes -a show both nodes 'free'. However, when I submit jobs they never run on the newly added machine - even after I set the first/original node offline to force jobs to run on the added node. Is this not the correct sequence of events? What is the meaning/efftect of: qmgr -c 'set queue foo resources_default.nodes=1' . Thanks _______________________________________________ torqueusers mailing list torqueusers at supercluster.org http://www.supercluster.org/mailman/listinfo/torqueusers -- Kevin Van Workum, Ph.D. Vice President Senior System Administrator www.clusterondemand.com ONLINE COMPUTER CLUSTERS -------------- next part -------------- An HTML attachment was scrubbed... URL: http://www.supercluster.org/pipermail/torqueusers/attachments/20070207/97c69d25/attachment.html


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August 9, 2012 | Volume 42, No.32
Roger Fish, left, checks out his motorcycle Monday after skidding out in front of resident Lemmie Spradlin, whose car is pictured. Spradlin was cited for making an unsafe turn from Second Avenue onto Young Road. Fish, a visitor from Tennessee, was just starting a motorcycle tour of Alaska with friends after debarking the ferry. Police chief Gary Lowe, at right in photo, has said he believes recent safety improvement to the intersection and a few others, changing them from "Y"-shaped to a "T," has made them more dangerous. Tom Morphet photo.
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FS-Inspect is an easy to use tool designed to give you an overview about your files and directories (Disk Usage).
On start up, it reads recursively the inspected directory and presents the content in two useful views:
* The folder view, shows the directory tree, sub-folders are sorted by size.
* The type view, shows all file types found, sorted by the total size.
In the post scan, the utility start searching for duplicates. All duplicates are listed in the file view, colored depending on their MD5-checksum.
It is possible to configure the duplicate search in the settings. To optimize the duplicate search, hashes are stored in a database. If a directory is inspected many a time, there is no need to compute the performance-expensive check-sum again.
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Rent A Handbook for the Art and Science of Teaching 1st edition today, or search our site for other textbooks by Robert J. Marzano. Every textbook comes with a 21-day "Any Reason" guarantee. Published by Heinle ELT.
Need help ASAP? We have you covered with 24/7 instant online tutoring. Connect with one of our Study-Skills tutors now.


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Bushwillow Tented Camp – Donna and JitenWed, 19 Jul 2017
It was early in the afternoon when I met Donna and Jiten for a coffee and a chat. I usually only meet couples on the evening so it made for a nice change to get out of the studio and into a bit of early spring sunlight.
We were talking and, I think it was Donna who casually mentioned that they were going to have their reception first and then their ceremony. I remember thinking that a sunset wedding sounds cool, some golden light coming through trees and the sun setting in the background. I made a mental note to make sure that we shot their portraits first while there was still light and then the family portraits.
I may have mentioned something to that effect when Donna said that the ceremony will be after sunset. Errm, ok, I've done some indoor weddings which were pretty killer bee. This one however was going to be outside, Donna and Jiten are both vets and they wanted to get married in nature. I was nodding, probably a little too nervously at this point. I blame it on the three espresso I've had in last two hours. I could bring some flashes, not what I'm known for but I've done many years in studio photography and I can light up pretty much anything.
Donna gave that smile of hers and dropped the final hurdle, she didn't want any artificial light, only candles. I smiled back, so to recap, you want a nighttime wedding, after dark, lit by candles, outdoors, and you want all your portraits and ceremony shots without any artificial light? I smiled and may have said, makes for a nice change.
Weeks later, during their portrait shoot, Donna turns to Jiten and laughs "I was going to dip you during the first kiss, you stole my thunder." He smiles back and she grins back and dips him in the candle light … All good stories should end this way.
More photos from Donna and Jiten's Bohemian Chic Wedding can be found on our Facebook Page.
More photos from Donna and Jiten's Bohemian Chic Wedding can be found on our Facebook Page.


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CantaMia, an adult community center in Goodyear, has won two of the nation's most prestigious awards from the National Association of Home Builders (NAHB).
CantaMia, which literally means "my song", celebrates the lives of adults who have had surprising career changes late in their lives and after their children have been raised.
The community is a gated 587-acre, boutique-sized development, within the master planned larger community of Estrella.
the CantaMia features 16 different floor plans intended to house various family types: from single family homes with optional guest houses, to "lock and leave" attached homes.
Recipients of the "Best Green Community" award from NAHB, all the homes have solar and green features which make them 60 percent more energy efficient than an average home.
The community has also received the "Best For Sale Community Over 200 Homes" award. The competition, which is sponsored by NAHB's 50+ Housing Council, is focused on the services providing housing for 50+ adults.
"We are extremely honored to have CantaMia win two significant NAHB awards, being judged against our competitors nationwide. This recognition of our commitment to create something fresh for the Baby Boomers marching toward retirement is very meaningful in this competitive industry," said Carl Mulac, President of Avatar Properties, Inc., the community builder and developer.
At the center of the CantaMia community is the 30,000 square foot Village Center. There, residents and community members enjoy a wide range of activities and demonstrations, including live healthy cooking sessions, Zumba, Tai Chi, swimming, etc.
Avatar Properties, Inc. is heavily engaged in the land and home development of the community, as it is with other projects across Florida and Arizona. CantaMia is one its two main projects, with the other being the Solivita project near Orlando.


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High quality square replacement belts in a variety of circumferences and widths.
Sold Individually.
108-145 - Temflex 1700 Vinyl Electrical Tape
PVC insulating electricians tape 7 mil x 3/4" 60' roll UL listed, CSA certified for 176°F
TL00180 - Electronic Screwdriver Set and Cutters
A high quality seven piece precision screwdriver and side cutter set. The ergonomically styled handles are color coded with revolving tops, and the blades are manufactured from nickel, chrome molybdenum steel with hardened, black tips. Ideal for electrical termina...
20-2715 - Single Tip Cotton 100 pk TechSwabs
Precisely designed, manufactured and packaged to serve the various cleaning and maintenance needs in the electronics industry. A variety of swab materials are available to suit many different applications.
42-125 - Square Belt
Square Belt with a 6.619" (168.12 mm) IC, and a thickness of 0.047" (1.19mm).
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Square Belt with a 6.2" (157.48 mm) IC, and a thickness of 0.046" (1.17mm).
Very fast shipping. Great prices and huge selection of products. I love this place.


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In Gmail: on the right-hand side of the email, click the arrow next to "Reply", and select "Show original". You will now see the email header. Look for "Sender" or "Return-Path" to see the originating domain and report them
In the new Yahoo! : select the message, click "Actions" on top of the reading pane, then select "Full Header" and look for the same thing.EDIT : sorry, I see you already looked at the headers, I'll leave the explanation though – maybe it's useful to others
very helpful…


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You may be a and devoted dentist Scottsdale individual but sometimes you CAn't avoid from your own tooth damaged being cracked or perhaps a lack of tooth because of numerous factors. Repair that is tooth helps you to provide the teeth & most possibly the environment to its situation that is prior. This can bring your grin back and maintain your tooth in-line in the same period.
What exactly would be the kinds of dentistry methods that are regenerative? You will find several techniques which are popular to displace your damaged, cracked and lacking tooth. THREE techniques; Tooth Links Dental Caps and Dental Improvements are most often used by Aesthetic dentists. Ceramic tooth veneers and Aesthetic tooth connecting, veneers also come under Dental Repair methods. With respect to the standing of the periodontal and also one's teeth your dentists might choose which kind of process is better to displace your tooth.request a free consult
The perfect process is by using Dental Improvements if you should be struggling with a damaged teeth or tooth. You'll need certainly to encounter lots of issues such as for instance difficulty in eating meals, not able to speak precisely and grinning generally should you choose not substitute your lacking tooth. To ensure that teeth links or veneers could be safely positioned Enhancements is likely to be mounted on your jaw-bone within your gumline.
Dentistry Links are accustomed to load the space of the teeth that was missing. It'd link the space between your tooth that are current. Two caps hold collectively the pontic. These pontics are made according the people choice of platinum, ceramic or metals.click for a free consult
Damaged or corroded teeth are renewed utilizing a tooth overhead. Is the teeth damaged or is corroded however the underlying is in good shape? A dentistry overhead will give you the addressing for the whole decayed or damaged teeth. It give a wide berth to it from additional harm and will additionally reinforce the teeth.call Badyal
Considered to be among the resources that are greatest to fix cracked damaged or damaged tooth is Veneers. There is like ceramic coating a skinny wafer used to relationship and protect the teeth that was broken. The connecting is performed possibly chemically or bodily. Because a great deal these ceramic veneers being slim has been enhanced by cosmetic-dentistry appear really organic. Therefore nobody may spot-the-difference between an actual teeth along with a renewed tooth.
When you yourself have an amalgam completing your teeth might appear dim. Your dentist may hide this deficiency using a Ceramic Overhead. The Ceramic Overhead certainly will provide you with the assurance to grin extensively and addresses the part of the teeth that will be darkish.
As previously mentioned above you are able to appropriate any of flaws or the damage utilizing regenerative dentistry methods. Knowing one's oral health's present condition is in identifying the therapy process of an ailment perfect. So the correct technique might be selected consult your dentist. With respect to the situation of gumline and one's tooth the best option repair could be utilized. Making certain you receive your grin again and also you possess the convenience of eating the food properly and therefore are in a position to talk precisely.fix your jaw today


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Graduate Schools in Bethel, Ohio
There are at least 8 colleges in the Bethel area that have graduate programs. This includes graduate schools in cities surrounding Bethel (Cincinnati). The specific degree types offered by each school are included below. Popular graduate degrees include Masters of Business Administration (MBA), Masters in Nursing (MSN), Doctor of Philosophy (Ph.D.), Doctor of Medicine (MD) and Doctor of Pharmacy (PharmD).
For more graduate school options, we have also compiled a list of featured Graduate Schools in Ohio.
These schools do not admit all qualified applicants.
Based on 2008-2009 information.
Art Academy of Cincinnati
1212 Jackson Street
Cincinnati, OH 45202-1706
Cincinnati Christian University
2700 Glenway Ave
Cincinnati, OH 45204-3200
University of Cincinnati-Main Campus
2624 Clifton Avenue
Cincinnati, OH 45221-0063
Hebrew Union College-Jewish Institute of Religion
3101 Clifton Ave
Cincinnati, OH 45220
College of Mount St. Joseph
5701 Delhi Rd
Cincinnati, OH 45233-1670
Union Institute & University
440 E McMillan St
Cincinnati, OH 45206-1925
Xavier University
3800 Victory Parkway
Cincinnati, OH 45207-1092
Schools open to most or all qualified applicants (qualifications vary).
Based on 2008-2009 information.
Athenaeum of Ohio
6616 Beechmont Ave
Cincinnati, OH 45230-2091
Bethel Colleges
Bethel colleges and trade schools.


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Here's how you can take photos while recording a video on your Android Jelly Bean device.
1. Start recording your video.
2. Tap the screen to take a photo.
3. Your photo will be saved to your device's gallery.
For more, see the original article at the link below.
50 Android Jelly Bean tips, tricks and hints | Tech Radar
This article is published as part of the IDG Contributor Network. Want to Join?


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In a nutshell....
The Fox watch Ultrasonic Pest Deterrent once it detects any fox within 40ft of its sensor will activate an ultrasonic alarm. This ultrasonic noise cannot be heard by humans, cats, birds or other garden wildlife, but is does cause foxes a degree of discomfort and puts them off.
The Fox Watch ultrasonic fox deterrent will protect an area of up to 1,350 square feet - up to twice the area of other makes and will rid your garden of foxes for 24 hours a day, 365 days a year. Foxes are an invasive species that will fearlessly home in on any area that offers a food source. They are also quite a nuisance, bringing destruction, death (to pets and livestock), disease (Weils disease, Toxacarisis) and causing a lot of disturbances.
The electronic fox deterrent works in all weather conditions and is designed to run, trouble free all year round. Fox watch is the perfect way to keep your garden or lawn fox free without the use of chemicals or fencing. It can be positioned at ground level, via the positioning stake, in seconds or can be secured to the base of walls, fences or trees. It also works on dogs, and will keep stray dogs away from your property, or can be used to keep the family pet from wandering onto the street.
It works like a motion detector, detecting movement and body heat within a radius of 40 ft and then emitting a unique ultrasonic alarm that is inaudible to the human ear. Very economic to run, it runs on a 9 volt alkaline battery which will last for 2-3 months. A separate mains adaptor is available on the site and enables the fox watch unit to operate at peak efficiency as opposed to the declining power of batteries. The mains power unit also increases the alarm by 30%.
Fox watch emits a unique ultrasound frequency pattern that will deter foxes from any garden, no matter how rich the food source. Humans and most animals such as; birds, frogs, hedgehogs and rabbits will not be able to hear the alarm, it only works on foxes and dogs.
From the supplier:
"Foxwatch is one of the most successful fox deterrent ever invented. And the reason is simple. It only uses the principles of animal behavioural response patterns to communicate the clear message or threat that the fox is not welcome."
Protects area up to 1350 square feet
All our UK deliveries are only £3.95 no matter how many products we deliver anywhere in mainland UK. For heavy items like raised beds or ponds we charge only £7.95 per complete order. We also deliver to other European countries, please see our rates below.
Our delivery fee is an absolute bargain and is far cheaper than any of our competitors, please take this into account when comparing product prices.
Heavy goods deliveries
For heavy raised bed or pond deliveries we charge an extra £4.00 to our standard delivery rate. Our rates below are our standard rates, please add £4.00 for heavy goods. All delivery rates are automatically added to your order when you add a product to your cart.
Where do we deliver to?
We deliver nationwide to the UK, the island of Ireland, Austria, Benelux Countries, Czech Republic, Denmark, Finland, France, Germany, Hungary, Italy, Norway, Poland, Portugal, Spain, Slovakia, Slovenia, Sweden and Switzerland. Please see our delivery rates below:
£3.95 - The United Kingdom and Island of Ireland (Highlands and Islands may incur a surcharge, please contact us on 0044 1788 298 795 for details)
£9.95 - Austria, Belguim, The Netherlands, Luxembourg, Denmark, France, Germany, Switzerland.
£19.95 - Czech Republic, Hungary, Italy, Poland, Slovakia, Slovenia, Sweden.
£24.95 - Finland, Norway, Portugal, Spain.
How long does delivery take?
Stock permitting we aim to dispatch your goods within 1 - 2 working days of receiving your order. The average time taken from order to delivery is 4 - 5 days in the UK and Ireland, and up to 6 working days for France, Germany and the Benelux countries.
Can I track the parcel myself?
When the order has been dispatched we will provide you with a tracking number for your shipment, you will be able to log on to the Parcel Force website and see where your parcel is at any time. You can also call the office on 01788 298 795 or email firstname.lastname@example.com if you need more information.
What If I'm not in at time of delivery?
The driver will leave a note with the depot contact number. Delivery can be arranged for the next day or a later date. The driver will not leave the parcel without a signature however they can leave your parcel with a neighbour if instructed to do so in our notes section at the checkout stage on the website. Alternatively if you are not home after Parcelforce/GLS have attempted delivery on 2 consecutive days they will leave a note to let you know that your parcel has been left at your local Post Office for collection.
I'm ordering several items, do they all arrive at the same time?
All items dispatched at the same time will normally be delivered in one delivery. The exceptions are bulk bags of soil or compost which comes in a separate delivery using a different delivery company.
What if my parcel is damaged or I wish to return the goods I have ordered?
Contact our office on 01788 298 795 and we will arrange collection and refund or replacement of faulty or damaged goods free of charge. We have a 'no quibble' policy on damages and will replace immediately once we receive an emailed photo of the damaged item.
If you wish to return an undamaged item for any reason we do charge a collection fee which may vary depending on the number of parcels, each case is different so please call us to arrange. We promise to keep returns fees fair and as low as possible. To arrange a return please contact our sales team on 01788 298 795
Great customer service is what we are all about. You will never have to worry about damages, the item not being as expected or simply deciding you don't want the item and you want to return it. We have a Free 30 day returns policy on Damaged goods but even if the item is not damaged you can return in for a Refund less a 15% restocking charge at any time within 30 days. We will even arrange collection from you Free of Charge. We can't get fairer than that.
Please note that the goods have to arrive back to us in the same condition that they left us so if you have opened your parcel you must ensure it is well enough packed to make it back to us not damaged.
Damaged Goods Returns
If the parcel is visibly damaged upon delivery, Do Not Sign for the Order. After that just email us on email@example.com and we will do the rest. Obviously it is not always possible to spot a damage in that moment of delivery so don't worry. As soon as you open your parcel if the goods are not as they should be just email us a photo of the issue clearly explaining the problem. We will be back to you within the day with a solution. This is normally to arrange a collection at a time that suits you and arrange for a replacement to be sent out. We have very few damages so we act very quickly. Please note the Photo is important so that we can claim off our couriers.
A Simple Return
So you have decided on receipt of the goods that you simple don't want them. Again simple. Just email us at email@example.com explaining that we want to return your goods clearly stating your name and your order number. We will arrange for collection on an agreed day. Once the goods arrive back in our warehouse and they have been checked as in the condition they left us we will refund you less 15% of the product value. We won't even charge you for the collection. Now it doesn't get any better than that.
European Returns
Customers outside of the UK and Ireland are covered by the damages Returns policy above. If you want to return your goods due to the fact that you no longer want it you simply email us on firstname.lastname@example.com and let us know. You will then need to return your goods to the following address and once it arrives back to us in the condition it left us we will refund you less the 15% restocking charge.
The address for European Returns is:
Quickcrop Ltd – Unit 13 Block A, Flurrybridge Business Park, Lower Foughill Road, Newry, Northern Ireland BT358SQ
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That cloud of chemicals rapidly descended upon the city, exposing hundreds of thousands of people in the vicinity to its lethal effects. By morning, thousands of men, women, children, livestock and vegetation had succumbed.
Bhopal Disaster Anniversary: A Look Back at One of History's Worst Industrial Tragedies [Pictures]
Current Status: Blessed (1)
Seeded on Fri Dec 9, 2011 3:26 AM
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