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Deadlocked (Sookie Stackhouse / Southern Vampire Series #12)by Charlaine Harris
It's vampire politics as usual around the town of Bon Temps, but never before have they hit so close to Sookie's heart...
Growing up with telepathic abilities, Sookie Stackhouse realized early on there were things she'd rather not know. And now that she's an adult, she also realizes that some things she knows about, she'd rather not seelike Eric
- Overview
- Editorial Reviews
- Product Details
- Related Subjects
- Read an Excerpt
- What People Are Saying
- Meet the author
It's vampire politics as usual around the town of Bon Temps, but never before have they hit so close to Sookie's heart...
Growing up with telepathic abilities, Sookie Stackhouse realized early on there were things she'd rather not know. And now that she's an adult, she also realizes that some things she knows about, she'd rather not seelike Eric Northman feeding off another woman. A younger one.
There's a thing or two she'd like to say about that, but she has to keep quietFelipe de Castro, the Vampire King of Louisiana (and Arkansas and Nevada), is in town. It's the worst possible time for a human body to show up in Eric's front yardespecially the body of the woman whose blood he just drank.
Now, it's up to Sookie and Bill, the official Area Five investigator, to solve the murder. Sookie thinks that, at least this time, the dead girl's fate has nothing to do with her. But she is wrong. She has an enemy, one far more devious than she would ever suspect, who's set out to make Sookie's world come crashing down.
Editorial Reviews
"It's the kind of book you look forward to reading before you go to bed, thinking you're only going to read one chapter, and then you end up reading seven."—Alan Ball, executive producer of True Blood
"Vivid, subtle, and funny in her portrayal of southern life."—Entertainment Weekly
"Charlaine Harris has vividly imagined telepathic barmaid Sookie Stackhouse and her small-town Louisiana milieu, where humans, vampires, shapeshifters, and other sentient critters live...Her mash-up of genres is delightful, taking elements from mysteries, horror stories, and romances."—Milwaukee Journal Sentinel
"The series continues to be inventive and funny with an engaging, smart, and sexy heroine."—The Denver Post
"Blending action, romance, and comedy, Harris has created a fully functioning world so very close to our own, except, of course, for the vamps and other supernatural creatures."—The Toronto Star
Product Details
- 9781937007447
- Publisher:
- Penguin Publishing Group
- Publication date:
- 05/01/2012
- Series:
- Sookie Stackhouse/Southern Vampire Series
- Pages:
- 336
- Product dimensions:
- 6.30(w) x 9.10(h) x 1.40(d)
- Age Range:
- 18 Years
Read an Excerpt
Chapter Two
Fairies. Never simple. My grandmother, Adele, would definitely have agreed. She'd had a long affair with Dermot's fraternal twin Fintan, and my aunt Linda and my father Corbett (both dead for years, now) had been the results.
"Maybe it's time for some plain speaking," I said, trying to look confident. "Niall, maybe you could tell us why you're pretending Dermot isn't standing right here. And why you put that crazy spell on him." Dr. Phil to the fae –– that was me.
Or not. Niall gave me his most lordly look.
"This one defied me," he said, tilting his head at his son.
Dermot bowed his head. I didn't know if he was keeping his eyes down so he wouldn't provoke Niall, or if he was concealing rage, or if he just couldn't think of where to begin.
Being related to Niall, even at two removes, was not easy. I couldn't imagine having a closer tie. If Niall's beauty and power had been united with a coherent course of action and a nobleness of purpose, he would have been very like an angel.
This conviction could not have popped into my head at a more inconvenient moment.
"You're looking at me strangely," Niall said. "What's wrong, dearest one?"
"In the time he's spent here," I said, "my great–uncle has been kind, hard–working, and smart. The only thing that's been wrong with Dermot is a bit of mental fragility, a direct result from being made crazy for years. So, why'd you do that? 'He defied me' isn't really an answer."
"You haven't got the right to question me," Niall said, in his most royal voice. "I am the only living prince of Faery."
"I don't know why that means I can't ask you questions. I'm an American," I said, standing tall.
The beautiful eyes examined me coldly. "I love you," he said very unlovingly, "but you're presuming too much."
"If you love me, or even if you just respect me a little, you need to answer my question. I love Dermot, too."
Claude was standing absolutely still, doing a great imitation of Switzerland. I knew he wasn't going to chime in on my side, or Dermot's side, or even Niall's side. To Claude, the only side was his.
"You allied yourself with the water fairies," Niall said to Dermot.
"After you cursed me," Dermot protested, looking up at his father briefly.
"You helped them kill Sookie's father," Niall said.
"I did not," Dermot said quietly. "And I'm not mistaken in this. Even Sookie believes this, and she lets me stay here."
"You weren't in your right mind. I know you would never do that if you hadn't been cursed," I said.
"You see her kindness, and yet you have none for me," Dermot told Niall. "Why did you curse me? Why?" He was looking directly at his father, his distress was written all over his face.
"But I didn't," Niall said. He sounded genuinely surprised. Finally, he was addressing Dermot directly. "I wouldn't addle the brains of my own son, half–human or not."
"Claude told me it was you who bespelled me." Dermot looked at Claude, who was still waiting to see which way the frog would jump.
"Claude," Niall said, the power in his voice making my head pound, "Who told you this?"
"It's common knowledge among the fae," Claude said. He'd been preparing himself for this, was braced to make his answer.
"According to whom?" Niall was not going to give up.
"Murry told me this."
"Murry told you I had cursed my son? Murry, the friend of my enemy Breandan?" Niall's elegant face was incredulous.
The Murry I killed with Gran's trowel? I thought, but I knew it was better not to interrupt.
"Murry told me this before he switched his allegiance," Claude said defensively.
"And who had told Murry?" Niall said, an edge of exasperation in his voice.
"I don't know." Claude shrugged. "He sounded so certain, I never questioned him."
"Claude, come with me," Niall said, after a moment's fraught silence. "We will talk to your father and to the rest of our people. We'll discover who spread this rumor about me. And we'll know who actually cursed Dermot, made him behave so."
I would have thought Claude would be ecstatic, since he'd been ready to return to Faery ever since entrance had been denied him. But he looked absolutely vexed, just for a moment.
"What about Dermot?" I asked.
"It's too dangerous for him now," Niall said. "The one who cursed him may be waiting to take further action against him. I'll take Claude with me . . . and Claude, if you cause any trouble with your human ways . . ."
"I understand. Dermot, will you take over at the club until I return?"
"I will," said Dermot, but he looked so dazed by the sudden turn of events that I wasn't sure he knew what he was saying.
Niall bent to kiss me on the mouth, and the subtle smell of fairy filled my nose. Then he and Claude flowed out the back door and into the woods. Walking is simply too jerky a word to describe their progress.
Dermot and I were left alone in my shabby living room. To my consternation, my great–uncle (who looked a tiny bit younger than me) began to weep. His knees crumpled, his whole body shook, and he pressed the heels of his hands to his eyes.
I covered the few feet between us and sank to the floor beside him. I put my arm around him and said, "I sure didn't expect any of that." I surprised a laugh out of him. He hiccupped, raising reddened eyes to meet mine. I stretched my free arm to reach the box of tissues on the table by the recliner. I extracted one and used it to pat Dermot's wet cheeks.
"I can't believe you're being so nice to me," he said. "It's seemed incredible to me from the beginning, considering what Claude told you."
I had been a little surprised myself, to tell you the truth.
I spoke from my heart. "I'm not convinced you were even there the night my parents died. If you were, I think you were under a compulsion. In my experience of you, you've been a total sweetie."
He leaned against me like a tired child. By now, a human guy would have made a huge effort to pull himself together. He'd be embarrassed at displaying vulnerability. Dermot seemed quite willing to let me comfort him.
"Are you feeling better now?" I asked, after a couple of minutes.
He inhaled deeply. I knew he was drawing in my fairy scent and that it would help him. "Yes," he said. "Yes."
"You probably need to get a shower and have a good night's sleep," I advised him, floundering for something to say that wouldn't sound totally lame, like I was coddling a toddler. "I bet Niall and Claude'll be back in no time, and you'll get to . . ." Then I had to trail off, since I didn't know what it was Dermot truly wanted. Claude, who'd been desperate to find a way to enter Faery, had gotten his wish. I'd assumed that had been Dermot's goal, too. After Claude and I had broken the spell on Dermot, I'd never asked him.
As Dermot trudged off to the bathroom, I went around the house checking all the windows and doors, part of my nightly ritual. I loaded a couple of dishes into the dishwasher while I tried to imagine what Claude and Niall might be doing at this moment. What could Faery look like? Like Oz, in the movie?
"Sookie," said Dermot, and I jerked myself into the here and now. He was standing in the kitchen wearing plaid sleep pants, his normal night gear. His golden hair was still damp from the shower.
"Feeling better?" I smiled at him.
"Yes. Could we sleep together tonight?"
It was as though he'd asked, "Can we catch a camel and keep it as a pet?" Because of Niall's questions about Claude and me, Dermot's request struck me kind of weird. I just wasn't in a fairy–loving mood, no matter how innocently he intended it. And truthfully, I wasn't sure he hadn't meant we should do more than sleep. "Ahhhhh . . . . no."
Dermot looked so disappointed that I caught myself feeling guilty. I couldn't stand it, I had to explain
"Listen, I understand that you don't intend that we have sex together, and I know that a couple of times in the past we've all slept in the same bed and we all slept like rocks . . . it was a good thing, a healing thing. But there are maybe ten reasons I don't want to do that again. Number One, it's just really peculiar, to a human. Two, I love Eric and I should only bunk down with him. Three, you're related to me, so sleeping in the same bed should make me feel really squicky inside. Also, you look enough like my brother to pass for him, which makes any kind of vaguely sexual situation double squicky. I know that's not ten, but I think that's enough."
"You don't find me attractive?"
"Completely beside the point!" My voice was rising, and I paused to give myself a second. I continued in a quieter tone. "It doesn't make any difference how attractive I find you. Of course you're handsome. Just like my brother. But I have no sex feelings about you, and I've come to realize the whole idea's just odd. So we're not doing the fairy sleep–a–thon of comfort any more."
"I'm sorry I've upset you," he said, even more miserably.
I felt guilty again. But I made myself suppress the twinge. "I don't think anyone in the world has a great–uncle like you," I said, but my voice was fond.
"I'll never bring it up again. I only sought comfort." He gave me Big Eyes. There was a hint of laughter turning up the corners of his mouth.
"You'll just have to comfort yourself," I said tartly.
He was smiling as he left the kitchen.
That night, for the first time in forever, I locked my bedroom door. I felt bad when I turned the latch, like I was dishonoring Dermot with my suspicions. But the last few years had taught me that one of my grandmother's favorite sayings was true. An ounce of prevention was worth a pound of cure.
If Dermot turned my doorknob during the night, I was too soundly asleep to hear it. And maybe my ability to drop off that deeply meant that on a basic level I trusted my great–uncle. Or trusted the lock. When I woke the next day, I could hear him working upstairs in the attic. His footsteps sounded right above my head.
"I made some coffee," I called up the stairs. He was down in a minute. Somewhere he'd acquired a pair of denim overalls, and since he wasn't wearing a shirt underneath he looked like he was about to take his place in the stripper lineup from the night before as The Sexy Farmer with the Big Pitchfork. I asked Sexy Farmer with a silent gesture if he wanted any toast, and he nodded, happy as a kid. Dermot loved plum jam, and I had a jar made by Maxine Fortenberry, Holly's future mother–in–law. His smile widened when he saw it.
"I was trying to get as much work finished as I could while it wasn't so hot," he explained. "I hope I didn't wake you up."
"Nope. I slept like a rock. What are you doing up there today?" Dermot had been inspired by HGTV to hang some doors in the walk–in attic to block off a part of the big room for storage, and he was turning the rest of the floored space into a bedroom for himself. He and Claude had been more or less bunking together in the small bedroom and sitting room up there. When we'd cleared out the attic, Dermot had decided to "repurpose" the space. He'd already painted the walls and refinished and resealed the plank floor. I believe he'd recaulked the windows, too.
"The floor is dry now, so I built the walls. Now I'm actually putting in the hardware to hang the doors. I'm hoping to get that done today and tomorrow. So if you have anything you want to store, the space will be ready."
When Dermot and Claude had helped me carry everything down from the packed attic, I'd gotten rid of the accumulated Stackhouse debris –– generations of discarded trash and treasures. I was practical enough to know that moldering things untouched for decades really weren't doing anyone any good, and the trash had gone in a large burn pile. The nice items had gone to an antique store in Shreveport. A few of the smaller items had already sold; I'd gotten a check from Brenda Hesterman and Donald Callaway at Splendide.
While the two dealers were at the house looking through the possibilities, Donald had discovered a secret drawer in one of the old pieces of furniture, a desk. In it, I'd found a treasure: a letter from my Gran to me, and a unique keepsake.
Dermot's head turned at some noise I couldn't yet hear. "Motorcycle coming," he said around a mouthful of toast and jelly, sounding almost eerily like Jason. I jerked myself back into the here and now.
I knew only one person who regularly travelled by motorcycle.
A moment after I heard the motor cut off, there was a knock at the front door. I sighed, reminding myself to remember days like this the next time I felt lonely. I was wearing sleep shorts and a big old T shirt, and I was a mess, but that would have to be the problem of my uninvited guest.
Mustapha Khan, Eric's daytime guy, was standing on the front porch. Since it was way too hot to wear leather, his "Blade" impersonation had suffered. But he managed to look plenty tough in a sleeveless denim shirt and jeans and his ever–present shades. He wore his hair in a geometric burr, a la the Wesley Snipes look in the movies, and I was sure he would have strapped huge weapons to his legs if the police would have let him.
"Good morning," I said, with moderate sincerity. "You want a cup of coffee? Or some lemonade?" I tacked on the lemonade because he was looking at me like I was crazy.
He shook his head in disgust. "I don't take stimulants," he said, and I remembered — too late — that he'd told me that before. "Some people just sleep their lives away," he remarked after glancing at the clock on the mantel. We walked back to the kitchen.
"Some people work late at night," I said, as Mustapha —who was a werewolf — stiffened at the sight and scent of Farmer Dermot.
"I see what kind of work you been doing late," Mustapha said.
I'd been about to explain that Dermot had been the one who'd worked late, while I'd only watched him work, but at Mustapha's tone I cancelled that plan. He didn't deserve an explanation. "Oh, don't be an idiot, you know this is my great–uncle," I said. "Dermot, you've met Mustapha Khan before. Eric's daytime guy." I thought it more tactful not to bring up the fact that Mustapha's real name was KeShawn Johnson.
"He doesn't look like anyone's great uncle," Mustapha snarled.
"But he is, and it's none of your business anyway."
Dermot hiked a blond eyebrow. "Do you want to make my presence an issue?" he asked. "I'm sitting here eating breakfast with my great niece. I have no problem with you."
Mustapha seemed to gather up his stoic Zen–like impassivity, part of his Blade persona, and within a few seconds he was his cool self. "If Eric don't have a problem with it, why should I?" he said. (It would have been nice if he had realized that earlier.) "I'm here to tell you a few things, Sookie."
"Sure. Have a seat."
"No thanks. Won't be here long enough."
"Warren didn't come with you?" Warren was most often on the back of Mustapha's motorcycle. Warren was a skinny little ex–con with pale skin and straggly blond hair and some gaps in his teeth, but he was a great shooter, according to Mustapha.
"Didn't figure I'd need a gun here." Mustapha looked away. He seemed really jangled. Odd. Werewolves were hard to read, but it didn't take a telepath to know that something was up with Mustapha Khan.
"Let's hope no one needs a gun. What's happening in Shreveport that you couldn't tell me over the phone?"
I sat down myself and waited for Mustapha to deliver his message. Eric could have left one on my answering machine or even sent me an emai,l rather than sending Mustapha –– but like most vamps, he didn't really have a rock–solid trust in electronics, especially if the news was important.
"You want him to hear this?" Mustapha tilted his head toward Dermot.
"You might be better off not knowing," I told Dermot. He gave the daytime man a level blue stare which warned Mustapha to be on his best behavior and rose, taking his mug with him. We heard the stairs creak as he mounted them. When Mustapha's Were hearing told him Dermot was out of earshot, he sat down opposite me and placed his hands side by side on the table very precisely. Style and attitude.
"Okay, I'm waiting," I said.
"Felipe de Castro is coming to Shreveport to talk about the disappearance of his buddy Victor."
"Oh, shit," I said.
"Say it, sister. We're in for it now." He smiled.
"That's it? That's the message?"
"Eric would like to you to come to Shreveport tomorrow night to greet Felipe."
"I won't see Eric till then?" I could feel my face narrow in a suspicious squint. That didn't suit me at all. The thin cracks in our relationship would only spread wider if we didn't get to spend time together.
"He has to get ready," Mustapha said, shrugging. "I don't know if he got to clean out his bathroom cabinets or change the sheets, or what. 'Has to get ready' is what he told me."
"Right," I said. "And that's it, that's the whole message?"
Mustapha hesitated. "I got some other things to tell you, not from Eric. Two things." He took off his sunglasses. His chocolate–chip eyes were downcast; Mustapha was not a happy camper.
"Okay, I'm ready." I was biting the inside of my mouth. If Mustapha could be stoical about Felipe's impending visit, I could too. We were at great risk. We had both participated in the plan to trap Victor Madden, regent of the state of Louisiana, put in place by King Felipe of Nevada; and we had helped to kill Victor and his entourage. What was more, I was pretty sure Felipe de Castro suspected all this with a high degree of certainty.
"First thing, from Pam."
Blonde and sardonic, Eric's child Pam was as close to a friend as I had among the vamps. I nodded, signaling Mustapha to deliver the message.
"She says, 'Tell Sookie that this is the hard time that will show what she is made of.'"
I cocked my head. "No advice other than that? Not too helpful. I figured as much." I'd pretty much assumed Felipe's post–Victor visit would be a very touchy one. But that Pam would warn me . . . seemed a bit odd.
"Harder than you know," Mustapha said intently.
I stared at him, waiting for more.
Maddeningly, he did not elaborate. I knew better than to ask him to. "The other thing is from me," he continued.
Only the fact that I'd had to control my face all my life kept me from giving him major Doubtful. Mustapha? Giving me advice?
"I'm a lone wolf," he said, by way of preamble.
I nodded. He hadn't affiliated with the Shreveport werewolves, all members of the Long Tooth pack.
"When I first blew into Shreveport, I looked into joining. I even went to a pack gathering," Mustapha said.
It was the first chink I'd seen in his "I'm badass and I don't need anyone" armor. I was startled that he'd even tried. Alcide Herveaux, the packleader in Shreveport, would have been glad to gain a strong wolf like Mustapha.
"The reason I didn't even consider it is because of Jannalynn," he said. Jannalynn Hopper was Alcide's enforcer. She was about as big as a wasp, and she had the same nature.
"Because Jannalynn's really tough and she would challenge someone as alpha as you?" I said.
He inclined his head. "She wouldn't leave me standing. She would push and push until we fought."
"You think she could win? Over you." I made it not quite a question. With Mustapha's size advantage and his greater experience, I could not fathom why Mustapha had a doubt he would be the victor.
He inclined his head again. "I do. Her spirit is big."
"She likes to feel in charge? She has to be the baddest bitch in the fight?"
"I was in the Hair of the Dog yesterday, early evening. Just to spend some time with the other Weres after I got through working for the vamps, get the smell of Eric's house out of my nose . . . though we got a deader hanging around at the Hair, lately. Anyway, Jannalynn was talking to Alcide while she was serving him a drink. She knows you loaned Merlotte some money to keep his bar afloat."
I shifted in my chair, suddenly uneasy. "I'm a little surprised Sam told her, but I didn't ask him to keep it a secret."
"I'm not so sure he did tell her. Jannalynn's not above snooping when she thinks she ought to know something, and she doesn't even think of it as snooping. She thinks of it as fact–gathering. Here's the bottom line . . . don't cross that bitch. You're on the borderline with her."
"Because I helped Sam? That doesn't make any sense." Though my sinking heart told me it did.
"Doesn't need to. You helped him when she couldn't. And that galls her. You ever seen her when she's got a mad on?"
"I've seen her in action." Sam always liked such challenging women. I could only conclude that she saved her softer, gentler side for him.
"Then you know how she treats people she sees as a threat."
"I wonder why Alcide hasn't picked Jannalynn as his first lady, or whatever the term is," I said, just to veer away from the subject for a moment. "He made her pack enforcer, but I would have thought he would pick the strongest female wolf as his mate."
"She'd love that," Mustapha said. "I can smell that on her. He can smell that on her. But she don't love Alcide, and he don't love her. She's not the kind of woman he likes. He likes women his own age, women with a little curve to 'em. Women like you."
"But she told Alcide . . ." I had to stop, because I was hopelessly confused. "A few weeks ago, she advised Alcide he should try to seduce me," I said awkwardly. "She thought I would be an asset to the pack."
"If you're confused, think how Jannalynn's feeling." Mustapha's face might have been carved in stone. "She's got a relationship with Sam, but you were able to save him when she wasn't. She halfway wants Alcide, but she knows he wanted you, too. She's big in the pack, and she knows you have pack protection. You know what she can do to people who don't."
I shuddered. "She does enjoy the enforcement," I said. "I've watched her. Thanks for the heads–up, Mustapha. If you'd like a drink or something to eat, the offer still stands."
"I'll take a glass of water," he said, and I got it in short order. I could hear one of Dermot's rented power tools going above our head in the attic, and though Mustapha cocked an eye toward the ceiling he didn't comment until he'd finished his drink. "Too bad he can't come with you to Shreveport," he said then. "Fairies are good fighters." Mustapha handed me his empty glass. "Thanks," he said. And then he was out the door.
What People are Saying About This
"The Sookie Stackhouse series seamlessly mixes sensuality, violence and humor as readers experience the people of small-town Louisiana through Sookie's eyes." Boulder Weekly
Meet the Author
Charlaine Harris is the #1 New York Times bestselling author of the Sookie Stackhouse and Midnight, Texas, fantasy/mystery series and the Aurora Teagarden, Harper Connelly, and Lily Bard mystery series. Her books have inspired HBO's True Blood, NBC's Midnight, Texas, and the Aurora Teagarden movies for Hallmark Movies & Mysteries. She has lived in the South her entire life.
Brief Biography
- Hometown:
- Southern Arkansas
- Date of Birth:
- November 25, 1951
- Place of Birth:
- Tunica, Mississippi
- Education:
- B.A. in English and Communication Arts, Rhodes, 1973
- Website:
- http://www.charlaineharris.com
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I cannot believe was had a wait an entire year for this book to come out. I have loved this series all the way up to the last two books (11 & 12) I think Ms.Harris must be tired of writing the southern vampire series. I think she is being so dis-ingenuousness to the characters she created. I cannot believe Eric and Sookie would ever interact with each other they way they have these past two books. She has tried to completely change Eric into something he's simply not. I am going to be soooo mad if Sookie ends up with Sam at the ends of this series; and it seems like that is indeed what's going to happen. I have to ask myself what was the whole point of this series and everything that Sookie has went through if she ends up with a man she could of had in the very first book within the first few chapters. What a let down.
I have been a fan of this series since the beginning... Last years book was a disappointment and this years book was not any better. I do believe it has lost its flare since the TV series Trueblood started. I miss the way the books use to tell the story of vampires and humans trying to come to an understanding. It just keeps getting further and further out there now. I am sick of the entire fairy thing. I am saddened by the way the wonderful writing of the books seemed to nose dive after the first season of TrueBlood :(
Completely disappointed by this book. It wasn't worth the 14.99 for 260 pages. I have never put my Nook down and walked away when reading a Charlaine Harris book. But with this one I did. It was like climbing a hill that never ended. The story never sped up or hooked me. It felt like Charlaine Harris just called it in. The good points were that the cluviel dor storyline ended..albeit very anti-climatically. I would not recommend this book to anyone. It has a TON of filler and very little plot lines that actually are need to know before you read the last book when it is released.
I don't think that Deadlocked lives up to the first few books. Characters that made this series fun and exciting have drastically changed. The plot is unbelievably easy to predict after a few chapters. Things are conveniently solved and swept under the rug. Worst, Ms. Harris has built Sookie and Eric's relationship over almost the whole series only to butchered it now. Sam is a good "best friend" and nothing more. After all, who was the one to attend to Sookie's needs (physically and emotionally) and protect her throughout these books? Sam did nothing for her but hooked up with worst possible girlfriends. Eric and Sookie's relationship add fun and interest to these books. Since Ms. Harris seem to have already decided who Sookie should have a happily ever after with, I will stop here and not buy the last book. What is the point of this make-believe world anyway? I am very disappointed and feel that I have wasted my time and money. I feel that Ms. Harris has done a good job of teasing the readers but could not deliver. I won't be buying or reading any more books from her.
I am a teen and love this series!!! Such an awesome story line. Finished it very quickly.
I am honestly shocked at some of the poor reviews-I felt this book continues in the same style as the rest of the series. At the beginning Sookie had a very narrow list of experience-but it has broadened to include not only other beings, but new ideas. I never saw these as books explaining the world of vampires, but the story of Sookie. So yes, a lot of time is spent with the ponderings of Sookie (she has a lot more to think about now), and they have become a bit more pragmatic and tougher, yet she still remains true to her core-a woman from a small southern town, with a Christian upbringing and a desire to find her place in the world. I was also surprised to see how many voiced displeasure with the unraveling of her relationship with Eric, I always felt it was a foregone conclusion. While Sookie loved many things about him, there are some fundamental differences in their belief systems that could never be overcome. From the very beginning she was shocked/dismayed at his lack of feeling for those around him. Honestly, I don't think that arrogance and disassociation can solely be blamed on his being vampire-Eric just really, really likes Eric! Also ultimately Eric could never give her what she truly craves-a sense of security and family (and lets not forget the whole scenario regarding his possible unlimited lifetime and her aging scenario) . I admit I have been rooting for Sam from the beginning-yes, he showed interest in her from the first book-but Sookie needed to learn more about herself before she could know what she really wants/needs. Go Team Sam! So count me as one who has been a fan from day one to today-and I anxiously/sadly await the final book.
I read this in one sitting and really wish I had saved the time to do something else, like weeding. It focused only on the fairy locket and her indecisiveness on what to do with it. Everything else was just bylines. Her interactions with Eric were extremely brief and filled with her whining and brooding instead of actually talking to him and listening to him to try to get the answers she wanted. As far as her 'working with Bill in an investigation' she had a couple of interactions where they spoke briefly, and one when he needed her help to rescue someone. Very misleading. Even the threat of the King of Nevada was thinly done, only making an appearance in the beginning. At least the fairy thing is finally done with. At 260 pages for the Nook and 76 pages longer in print it was not worth the money paid.
I have been committed to this series from the beginning. The last novel was lackluster and this was not any better. It's sad to see these beloved characters not remain true to form. The author seems to have lost her vision for the very characters that drew so many to her novels. Much of the book seemed to lack direction...as if the author began writing without a concept in mind. I had to put it down...I regret the purchase. Heartbreaking for me to say....
I enjoyed this book because it wrapped up a bunch of story branches while leaving a few for the last book in the series. That being said, this book definitely feels like the ramp up to the last book, in that certain characters and situations are introduced as a lead in for things that will likely happen in the final book; while this is necessary, it does feel like Sookie is being pulled in so many different directions, and it can be slightly exhausting for the reader. As an Eric fan, this book was both good and bad. Not everything had been wrapped up with him, and it is unclear as to how his and Sookie's story line will progress into the final book. I often felt like she was dragging on the situations with him, and I wanted there to be some solid decisions made. I would be extremely disappointed if the 13th book ends the relationship and tries to shoehorn in a new one: why drag out this tension between Sookie and Eric for 12 books if there is no final payout? There is a lot up for interpretation at this point, and it will definitely be a long year until the 13th book is released.
Save your money. I wish I had. Charlene Harris has just phoned in the last few books. I won't buy another, nor will I use brain energy to read them anymore. Shame really, I was in love with the series until two books ago when it started feeling like she was fulfilling a contract, not actually developing characters and telling a good story.
Disappointing, poor interactions between characters. I used to love this series but the past two books have definitely been lacking. Not worth $14.99
I am extremely disappointed in this book. Based on the author'S comments regarding how badly she felt about her prior Sookie book, whuch I agree was also bad, i had big hopes for this one and am even more disappiinted. i strongly urge Ms. Harris to take her time and really WRITE the next one rather than trying to meet some market deadline. She wrote some truky good books so i know its possible but its been too long since. She is at serious risk of losing her audience and reputation and self~respect as a writer if she doesnt get back to her real abilities. please Ms. Harris. show your true fans that you can still do it! PLEASE !!!
I finished the book on day of release. I have to say that I agree with the others who are disappointed and am happy that there is only 1 book left in this series. The beginnings of the book seem to rehash the last book and rehash the backgrounds of all the characters. It seems to me as if, at this point, Ms. Harris is mainly writing for profit and banking on the success of True Blood. You wait a year for a book and it comes out and it's really no more then a recap for the first few chapters. I will say that the book got better in the 2nd half and I was "just okay" with the ending. I do hope that in her final book of the series we get a bit more meat and revisit the original style of the first few books.
I love Sookie and I love Eric. But this book did not, at all, seem true to their personalities. Sookie complained and whined, Eric was cold, neither of them spoke to each other. Nothing was resolved or really even expanded upon. This could have just been added on to book 11. I'm so frustrated with this book! I really, really, hope the last book will be more fulfilling.
Very disipointed in this book. I started reading this series last year when I lost my job and was instantly hooked. I read all the books in 1 weeks time and was so excited for this one to be released. The storyline never really came together. It seemed to me like it was the material that was left over from the last book, and she just used it to release another book. I was very disipointed in the Eric/Sookie resolution. It never really got anywhere. I hope the last one is better than this one.
Answering Cane315's Question: This is the next to last Sookie Stackhouse book. There will be one more, then that will be it. That's what penultimate means from the Publisher's Weekly review (and yes, I had to look it up, never heard of it before). The book itself was much better than the last two. I almost didn't buy it cause I was so disappointed in them. I'm sick of all the rehashing that Charlaine Harris does. Seems like 1/3 of the last few books has just been repeating what happened in previous books. That gets old fast. There is some recapping in Deadlocked, but not as bad as before.
3.5 stars Wow, this one is going to be tricky for me. I am a long time Sookie Stackhouse fan and have never not loved a Sookie book. Until now (insert sad face here). Like always, Sookie finds herself, unwittingly, wrapped up in some vampy and wolfie drama. All the vampires and werewolves seem to make an appearance in Deadlocked. So, let's start with the human. Sookie: Sookie was lost through most of this installment. She has much on her mind. She has enemies in places she would have never expected. Her friends and family are moving along in life in all too human ways, which of course she is not ~ dating a vampire and all. Her relationship with Eric (*swoon*) is rocky at best. As is her relationship with Alcide. She's still got Fae living in her house which causes all sorts of strange. The Vampire King still suspects her of things that, of course, she is very guilty of. The poor girl just can't seem to catch a break. Eric: Eric was entire too absent in this book. I want him present and fighting for the woman he loves. On the other hand, I want Sookie fighting for him. It doesn't always have to be a damsel, maybe it can be a dude in distress that needs rescuing. Maybe that is exactly what he has always lacked. Sure, he has loyalty and respect and love even from some of his children and minions. But has anyone actually fought for his love? Is that what will turn this bad boy good? Or, is he just to self serving to chose Sookie over the Queen? Say it aint so Charlaine!!! Bill: I don't have much to say about Bill. Bill is Bill and will always Bill. Bill will always love Sookie. Yada, yada, yada, yada. Can you tell who's team I would vote for? Sam: OMG Sam!! Sam makes the dumbest girlfriend decisions but every book he scores a few more points as just an all around great guy and friend. That doesn't change in Deadlocked. At all. He's pretty amazing. I am a fan. Nearly every (still living) character makes an appearance in Deadlocked. Is that because we are nearing an end to the Stackhouse series? I kind of hope so. Deadlocked didn't have the same punch as so many of it's series predecessors. Though it wrapped up a few open ended items from the previous stories, it really didn't progress the meat of the story much for me. I am left with the same feeling as I had at the end of Dead Reckoning. I'm tired of the love triangle. I'm tired of Sookie not being happy. I'm tired of Sookie almost getting killed. Etc, etc, etc... I'm ready for all loose ends to be tied up. It makes me really sad to say (er, type) that. Just trying to be honest here. I'm not giving up on the series and if Charlaine wants to write another five books I will do my best to continue as the same loyal fan I have always been. But, maybe it's time. Right? Or do you think I am way off base here?
I was really looking forward to reading Deadlocked but in the end I was some what disappointed with it. I made sure to go out and purchase it the first day it came out as and hoped it would have been better then the last book in the series. I wish that Mrs. Harris would have done a better job with Sookie and Eric relationship in this book. Nothing was settled with them and everything else was just left there. Nothing was solved and nothing completed. Not sure the final book will be any better. I really don't think everything can be left finished unless Mrs. Harris decides to write a book twice as long. Oh well I guess we will have to see next year.
I really enjoyed this book. It was such frivolous fun. I have a feeling that a lot of people who said they did not like the book are just kind of disappointed that it looks like Eric and Sookie are probably over. I liked them together but I realize that just because I liked them as a couple maybe the author wants to go in a different direction. I used to be kind of bugged by all the rehashing the author did but that was because I read book 1-12 one right after the other. This time I waited almost a year between reading the last book and this one and I realized I had forgotten a lot and kind of appreciated some of the rehashing. I really can't wait until the last book comes out. I hope Sookie doesn't wind up with Sam, mainly because I I'm hoping for some weird twist of an ending and not something that a lot of people have been predicting. I like the Sam character just fine but I don't really feel chemistry between him and Sookie. I can't picture her with a vamp either though because Sookie will grow old and die while a vampire will remain ageless. I can't picture that being a likely scenario. However it ends, I can't wait to find out. Charlaine Harris may not be going to win any Pulitzer Prizes but her Sookie Stackhouse series is super fun and funny. I like the way she rambles on a bit about Sookie's thoughts as I think a lot of people find her to be a relatable character because of this. Don't let the bad reviews scare you away. This book is such fun to read.
Yes i finished the book the same day it came out. I am and have been a fan of this series. I will, as it seems I maybe one of the few, finish this to the very end. While i think that the last 2, borderline 3 books, have lackluster with the story telling and rehashing of past events. Overall it was a good read. And while on my reader it states that there was only 260 pages, it was in fact 339, i felt it needed to be a little longer. Sookie has avoided the elephant in the room long enough, which for me is not one of her characteristics. I miss the head strong, confrontational Sookie that makes her character so likible. While I do see Mrs. Harris tying up loose ends with characters and giving them their happy ever after, I hope she gives Sookie hers too, and I don't mean Sam either. Why build up a relationship between Sookie and Eric only to defile it with a mediocre Sam. I don't think Naill will allow her to not have evrything, that defys everything he's pulled strings to make happy. I love reading this fictional series, because it's just that fiction... I for one want a epic final book where Sookie gets what she wants, a faery tail ending.
Very satisfying annual installment! I've read the entire series and look forward annually to the arrival of the next book. I like the books so much better than the TV series. The humor and asides in the books make me laugh out loud. I feel connected to the characters and their strange, twisty-turny lives -- and, thankfully, not quite as dark as the show. This year was a great convoluted mystery plot and a satifying tie-up of a lot of the goings-on the last couple of years, but still leaves the Eric question 'will he/ won't he'. And the return of Quinn?
This one was worse than the previous book, and i didn't think that was possible. Not much of a storyline, just a bunch of filler. I hope the next book, which is the last in the series, will do justice to what i once thought was an amazing book series.
Having never before written a review of a book, I simply had to after I finished Deadlocked. This book was HORRIBLE! The plot is silly, filled with stupid plot twists, mundane details - but honestly, it's so poorly written and not what I've come to expect from Ms. Harris having read every single Sookie Stackhouse novel before this. It's so disappointing. A suggestion to Ms. Harris: read your first few novels that YOU wrote in this series and see if you can recapture some of your own magic. As far as I'm concerned, you need your own cluveil dor.
And that half would be in generosity ONLY because I have been a MAJOR fan from the beginning and because the ending still gives Harris room to redeem herself!!! *spolier alert* I've been Team Eric from the start, but I don't even write as a fan who's fav character isn't going to end up with the heroine, I write as a fan who's characters have been BUTCHERED!!!!!! Where did Eric go, and who is the empty shell/rude and unforgiveable/ needy and helpless ghost of a vamp you have replaced him with???? After over 1000 years and 11 books worth of developing his character, she REALLY took him apart!!! Sookie, where to begin?? The ONLY reason I was still reading the books is because I was not faced with the heroine of True Blood who one minute is screaming about something, then whining about things not going her way, then refusing to face the problems in her life and blaming the result on everyone else around her and doesn't even care enough about anything outside herself to feel bad about killing people. I understand that she has been through life-changing situations in the last few books, but even the essence of who she is is not there anymore... The emotional wreck got to me the, most...The scene where she thinks Sam has gone and married the were and she LITERALLY EXPLODES I was like huh???? Then when she burst into tears I was like ok Harris you're losing me! Alcide, i KNOW he has changed A LOT since he became packmaster, but in her bed though??? I mean COME ON??? Surely Harris, shouldn't the core of these characters remain the same, this read like completely new people we'd never met, not characters we'd grown with and loved! The icing on the cake though was we got to spend A LOT of time with individuals that we did not even care about... Jane Bodehouse, JB's parents, Officers in Shreveport (for a storyline that could have been ommitted and it wouldn't change the book much) We got more questions that probably won't ever be answered such as why did Claude curse Dermot, then suggest the cure? How did he get away from Niall who was suspecting him pf the curse? Why would he alter himself to exist with humans, when he had been working to overthrow Niall all the while? Why did Freyda go to see Sookie? How long has she been communicating with Eric? What was the point of the writer coming to Sookie's house with the parents? Was there another vampire at Sup bar in shreveport? What was the point of telling us about the were and the vamp who are dating? What were the fae plotting? What is so bad about Bellenos that even got a reaction from Niall? The cherry on top though, was, it felt like Harris was setting it up to show us that the only constantly good thing that has been in Sookie's life has been Sam... All of a sudden she realizes that they're best buds and she is almost having a nervous breakdown because she thinks he's married and the best birthday gift came from him when previously he's only gotten 3 minutes of fame (if that)!!!! I'd rather she gave us Quinn as the potential see where it goes... Sam is just a comp out and an insult to my reading all 12 books the last 2 of which have been rip-off!!! I miss the carefree, entertaining, can't-wait-for-next-May-to-see-what-happens-next books that we got until (maybe) book 10 and that's a STRONG maybe! I hope she saves face even if its not a Sookie-Eric HEA I'll take my favorite joire de vivre Sheriff/Viking/doesn'ttakecrapfromanyoneandisuberSCARY yet you CAN'T help but love him GORGEOUS Vamp!
I love this series...but REALLY!!!!! What was the point of this book? The best part of the plot in the entire series has beenEric & Sookie and to leave us with this ending on the 2nd to the last book really makes me mad!! Not to mention i was so excited about this book that i pre-ordered it... a first for me.. well when i finally got home to read it, it would not open!!!!! I tried for ever..finally getting so frustrated i re-bought it.... again really!!! I will wait to see everyones comments on the last book before i even think about buying it... Mrs.Harris has some explaining to do!!!!!!!!!


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subset: commoncrawl


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My Notes:
This home plan could save you an average of $1,412 per year in energy costs »
From the FL-417 Toll, take EXIT 17 Boggy Creek Rd. toward International Airport. HEAD SOUTH onto Boggy Creek Rd. TURN RIGHT onto Lake Nona Blvd. The community will be straight ahead.
If using a GPS: Input the intersection of Wyndham Lakes Blvd and Lake Nona Blvd. Orlando, FL 32824.
The Madeira II at Somerset Park in Lake Nona features 4 bedrooms, 3 baths all on one floor with the optional bonus room for additional space upstairs to provide over 2,900 sq. ft. of living area. The floor plan is highly functional and comfortable. The grand kitchen is highlighted with an open breakfast bar and a kitchen nook overlooking the covered lanai. The three way split bedroom plan features two spacious bedrooms on one side of the home both equal in size and share a hall bath and the 4th bedroom and bath are privately located away from the other rooms. The master bath features double sinks, a glass shower, a separate garden tub, and a compartmentalized toilet area. At the rear of the bathroom is an oversized walk-in closet. This home is both stylish and well-built with M/I Standards, which will provide years of enjoyment and pride for your family and their lifestyle. Call today to schedule a tour!


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Executive director Rick Rogers will speak of his years of experience with nonprofits at the monthly Christian Chamber meeting Oct. 22
Newberg Area Habitat for Humanity Executive Director Rick Rogers is a firm believer that doing good things will come back around to you and believes his organization has proven to be a perfect example.
I think thats really important, Rogers said. We couldnt do what we do without the plumber, the roofer, the electrician and so on. Id like to think the people that support us would also support the businesses that support Habitat. Thats the way I think it should be.
How he and others at the housing ministry balance their charitable mission and the realities of running a small business will be among the topics Rogers covers when he addresses the Christian Chamber of Commerce of the Northwest at its monthly meeting in Newberg Oct. 22.
Rogers has nearly three decades of experience working with nonprofit organizations in a wide variety of areas, from overseas development, grant writing, accounting, public health, transitional housing for the homeless and self-help housing.
Although he has spent the past 14 years in Newberg, raising three boys with wife, Lisa, and working 13 of those for Habitat for Humanity, Rogers passion for nonprofit work was kindled while living a significant portion of his childhood abroad. That may come as a surprise to some who have known him as a visible and stable member of the Newberg community over the past decade.
In addition to his work with Habitat, Rogers serves on two Newberg city government committees and will begin his seventh season as the Newberg Rugby Club high school boys head coach next spring. As a parent of three former standout swimmers/water polo players at Newberg High School, its fair to add that hes been a vocal member of the community as well, considering he led chants of NEW-BERG TIG-ERS here we go, New-berg Tig-ers HERE WE GO from the stands at the Chehalem Aquatic Center over the years.
Rogers was raised in Hawaii until seventh grade, when his father took a job with Dole and moved the family to a plantation in the Philippines for the next four years.
With no suitable educational options after his parents moved to the interior of Brazil his junior year, Rogers finished high school at the Deerfield Academy in Deefield, Mass.
Rogers jokes that the transition from attending a 100-student school on a plantation overseas to boarding at one of the most traditional prep schools in the country was not only a shock to his system, but explains his psychosis to this day.
It didnt cure his desire to live abroad, however, as he took a year off after graduating high school to teach English in northeastern Brazil, which gave him his first brush with the development work that would greatly shape his career.
After college, Rogers had stints working in banking and journalism, including in Brazil, where he later worked with a small commissary business at the United States Consolate, which helped kindle his interest in nonprofit agencies.
Rogers briefly attended the Thunderbird School of Global Management in Glendale, Ariz., but when an opportunity to take a fellowship evaluating an aid organization at the U.S. Embassy in the west African nation of Guinea Bassao, he changed course.
Traveling with Lisa and their two boys at the time, the original 90-day assignment led to job offers for both at two aid organizations Lisa at USAID and Rick with Africare that made the trip a semi-permanent move that was ended by a medical emergency that called for Lisa to be taken to London.
The sad thing about it was all these aid organizations were in Guinea Bassao there were Russians, Americans, Swedes and Chinese and all this then all of a sudden, of course, there was a coup, Rogers said. The country is sort of a failed state now.
The couple relocated the family to Arizona, where Rick worked in public health at a grant-writing organization and Lisa in housing, but they eventually tired of the climate and chose to relocate to Oregon, as Lisa had attended college at the University of Washington and enjoyed the region.
It was Lisa who started a job with the housing group CASA of Oregon that brought them to Newberg in 1999; a year later Rick signed on with Habitat to assist with grants. A year later he took over as executive director.
It also opened my eyes that there is plenty of need here, too, Rogers said of his time living and working abroad. We dont need to go very far to find need, even like in Newberg. Sometimes I think were drawn overseas because of all the differences, but theres plenty of need here. Newberg is diverse in a lot of ways we dont necessarily see. That certainly drew me to it.


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EDITORIALS>>Taxpayers fleeced again
You may remember that press conference in Little Rocks River Market five years ago when a buoyant County Judge Buddy Villines and other swells announced that the county was issuing $43 million in municipal bonds, which was going to put 400 to 600 low-income families into homes that they would own.
They would be deserving families who simply could not get loans in the normal mortgage market because they were credit risks. Borrowing $43 million in the taxpayers name was not going to put one dime of the publics money at risk because private groups would handle the program, the judge pointed out.
The county was merely lending its good name so that the groups could borrow the money more cheaply since investors would not have to pay income taxes on their bond-interest earnings.
Not long afterward, President Bush touted the program at the White House by introducing a couple who had acquired one of the modest homes.
The Arkansas Democrat Gazette reported this week that the program had quietly crashed, but not before private interests in California and France that put the deal together and a phalanx of bond dealers and lawyers made off with a cool $2.5 million.
And what about those 400 to 600 new homeowners? The Pulaski County Public Facilities Board put exactly six families in modest dwellings at a cost of $2.1 million. Thats it: six families, $2.1 million. And President Bushs proud examples? They were out of the house within months, leaving debts and needed repairs.
The county government and you, the taxpayers may end up suffering more than humiliation for this boondoggle. The federal government wants the county or the bond investors someone to compensate it for the governments losses.
While the bonds did not cost the county anything, the federal government and that also is you was subsidizing the whole enterprise. Thats what municipal bonds are a federal subsidy for public projects.
The government exempts from income taxes the interest that investors earn from municipal bonds so that the investors will accept a lower interest rate on the investment.
This stimulates private investment in projects that have public benefits, like highways, hospitals, libraries, schools and universities, and reduces the borrowing costs for the agencies or private groups undertaking the program because interest rates are lower.
It is clear now that the principal beneficiaries of the $43 million bond issue was not the public but private entrepreneurs a French bank, a Beverly Hills, Calif., brokerage, and brokers and lawyers in Little Rock so the Internal Revenue Service now wants the income taxes that it gave up.
The French bank got $1.9 million for its troubles. And, oh, a Little Rock outfit created by a church received $50,000 for a 14-page report on the feasibility of the project. The churchs leaders had prayed and got Gods clearance to undertake it.
The Dream to Own program was not a bad idea. Throughout the South and elsewhere, community development corporations are struggling with similar programs that help low-income people overcome their credit issues and become homeowners.
They dont get $43 million handed to them. This was a program undertaken by people who knew little about how to do it; it was principally a way to make some easy money.
The county government is guilty not of corruption but naïveté in surrendering its imprimatur so casually to private groups about whom it knew nothing. The county had no accountability and demanded none.
The County Public Facilities Board and the Quorum Court do this routinely for a variety of enterprises of questionable public benefit.
They authorize government bonds to be issued in the countys name for private school interests $31 million in refinancing for the Pulaski Academy school for the children of the well-to-do in Little Rock, which apparently helped the academy buy the abandoned Fellowship Bible Church property (the church was building a new facility and needed to sell the old one), and $2.5 million to allow Arkansas Baptist School to build a junior high at a savings.
In a sense, its your federal and state income tax dollars at work.
Wed like our county government to be more stinting, more demanding and, yes, smarter.


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A particle moves with acceleration `a(t)` m/s^2 along an s-axis and has velocity `v_0` m/s at time `t=0` . Find the displacement AND the distance traveled by the particle during the given...
A particle moves with acceleration `a(t)` m/s^2 along an s-axis and has velocity `v_0` m/s at time `t=0` . Find the displacement AND the distance traveled by the particle during the given time interval.
`a(t)=9 ; `
`v_0=-1 ; `
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2 Answers
`a(t) = (dV(t))/(dt)`
`dV(t) = a(t)dt`
`intdV(t) = inta(t)dt`
`V(t) = int9dt`
`V(t) = 9t+C`
`V(0) = 9xx0+C`
`V(t) = 9t-1`
`V(t) = (dS(t))/(dt)`
`S(t) = intV(t)dt`
`S(t) = int(9t-1)dt`
`S(t) = 9t^2/2-t+D` where D is a constant.
It is given that the time interval is `0<=t<=2`
Displacement of particle `= S(2)-S(0)`
Displacement of particle `= (9xx4/2-2) = 16m`
For distance travelled;
`S(t) = int_0^2(9t-1)dt`
`S(t) = [9t^2/2-t]_0^2`
`S(t) = (9xx4/2-2) = 16`
So the displacement and distance travelled by the particle is 16m.
The particle moves along a straight line with initial velocity `v_0` = -1 m/s and acceleration a(t) = 9 m/s^2. The distance traveled by the particle during a duration of time equal to t is `s = v_0*t + (1/2)*a(t)*t^2` .
Substituting the given values the displacement of the particle in the period from t = 0 to t = 2 is:
(2 - 0)*9 + (1/2)*9*(2 - 0)
=> 18 + 9
=> 27
The particle travels 27 m in the given interval.
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Thank you for your response. Wiley Plus is saying 27m is incorrect. I should have mentioned it, but we are asked to solve using integration, where:
displacement= `int_(t_0)^(t_1)v(t)dt`
and distance traveled = `int_(t_0)^(t_1)|v(t)|dt`
I found that displacement = 16, but am not sure where I went wrong trying to obtain distance traveled (it does not equal 16, atleast according to wiley) Thank you in advance if you are able to help clarify.


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Tunnel Cables Cowl by Kristin Hansen
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© Patternworks
Tunnel Cables Cowl
Available as part of Patternworks' Hand-Dyed Cowl of the Month Club. This is the Month #1 kit.
For more information, see: http://www.patternworks.com/productdetail/900320/HAN...


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RFE: Conference Listings
This service is a joint project of RFE and EconBiz.
Institute for Fiscal Studies IFS, London
- Dates:
- April 27-27, 2009
- Description:
- The impact and design of business taxation in a globalised world - Conference
- Location:
- London, Westminster, One Birdcage Walk , United Kingdom
- Subject:
- The topics are all highly relevant to European business tax policy. The papers: - examine the level and determinants of effective tax rates paid by corporations in the UK, Europe and elsewhere; - consider non-profit taxes paid by business, and in particular ask how far such taxes are passed on to the workforce; - investigate the benefits of housing headquarter companies; - evaluate two policy proposals by the European Commission: the Common Consolidated Corporate Tax Base (CCCTB), and the proposals to apply VAT to financial services companies.[gem?_?? den Informationen des Anbieters - according to site editor's information]
- Notes:
- JEL Code:
- Sponsor:
- http://www.ifs.org.uk/events/432


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Tag Archives: Luis Scola
With no answer for Ellis, Rockets get rolled
There's a sour taste in my mouth, and it has little to do with these Chewy Lemonheads I raided from my kid's Halloween bag. Houston's defense, the team's primary focus during training camp (See: 1 | 2 | 3), was a no-show Wednesday night as Monta Ellis ruptured the Rockets for 46 points to lead the Warriors to a 132-128 win and drop Houston to 0-2. Continue reading
Houston Rockets 2010-11 Season Preview
With early training camp buzz pointing to a shift in focus from run and gun offensive firepower to a more "Van Gundian" recommitment to defensive intensity, it is clear that the Houston Rockets enter the 2010-11 season with a sense of determination. Continue reading
Rockets, Scola brighten day of man battling cancer
Kaes Maish's life was turned upside-down nearly 5 years ago when he was diagnosed with cancer. The father of four has been through the harsh treatments — chemo, radiation and most recently proton therapy — but each time he takes a step forward, it seems to knock him two steps back. Continue reading
Scola believes Rockets need to return to defensive identity
For 7 straight seasons the Rockets were in the top 5 in defensive field goal percentage, establishing a reputation as a tough, gritty team capable of beating any squad, any night. Continue reading


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McClain-L ArchivesArchiver > McClain > 2008-09 > 1222695822
From: ,
Subject: [MCCLAIN] MacLaine Descendants DNA Group
Date: Mon, 29 Sep 2008 13:43:42 -0000
This is a Message Board Post that is gatewayed to this mailing list.
Author: Beal1866
Classification: queries
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Message Board Post:
If any members have done or are deciding to do genetic DNA, I've started a DNA group for descendants of MacLaines, including all septs of the surname. Y-DNA is passed from father to son and mtDNA is passed from your direct maternal line. If you have done DNA tests from another service, you can add your results to ancestry.
Important Note:
The author of this message may not be subscribed to this list. If you would like to reply to them, please click on the Message Board URL link above and respond on the board.
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The best auto detailers do everything by hand while making comforting wash-tunnel noises with their mouths. Treat your car to a human touch with this Groupon.
Choose from Three Options
- $17 for a mobile car wash with tire shine, express wax, vacuum, and vent cleaning (a $39 value)
- $59 for a complete interior and exterior detail for a car (a $256 value)
- $69 for a complete interior and exterior detail for an SUV (a $320 value)

For all options, technicians will travel to locations within a 20-mile radius of downtown San Jose.

Pink Mobile Car Wash
Sometimes, even driving a prized automobile to the detail shop is more risk than an owner is willing to take. That's why Pink Mobile Car Wash comes to them—the company's insured technicians bring all the equipment they need to tackle automotive dirt and imperfections at clients' homes. Whether it's a muscle car, a motor home, or a family minivan, the techs will wax, scrub, and vacuum the interior and exterior while the vehicle sits its own driveway or plays with its favorite toys in its own garage. To remedy more advanced forms of filth and damage, they also detail carpeting and clean upholstery.


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March 31, 2014, Are Corporations Really People?
Knowledge@Wharton: We're speaking today with Eric Orts, a professor of legal studies and business ethics at Wharton, about his new book, Business Persons, a Legal Theory of the Firm. Thanks for joining us today, Eric.
Eric W. Orts: You're welcome. I'm happy to be here.
Knowledge@Wharton: The book covers a lot of ground. But let's focus on a couple of specific ideas that were very interesting. One has to do with … the Citizens United Supreme Court case, which gave corporations the right to spend unlimited amounts on political groups, campaigns and candidates. So, based on Citizens United, corporations are people too, right? Or are they?
Orts: Well, that's one of the main questions that I try to answer in the book or at least elucidate. The title of the book includes the phrase "business persons." What I mainly argue … is that corporations are persons, but that doesn't mean that they are people. Therefore, as the majority of the Supreme Court said, they have all of the rights, apparently, that people do...


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The times were dead level at the end of the race, forcing officials to look back at last Sunday's prologue times.
And Feillu was confirmed as the yellow jersey winner by just 0.49 seconds.
Birmingham's Paul Manning broke for home in the final mile to take the stage win from Dumfries to Glasgow in his final Tour of Britain appearance.
The 32-year-old, who has two Olympic medals in the team pursuit, will retire from cycling after Beijing next year.
Mark Cavendish capped a fantastic week by winning the sprints competition and the green jersey.
The Isle of Man rider, who won the prologue and the first stage in Southampton, said: "I was really motivated to do something for the home crowds this week.
"To win the prologue, the first stage and the two competitions is a fantastic feeling.
"It would have been nice to take another stage but I'm delighted Paul has got one and it's been a good week for British cycling."
Rotherham's Ben Swift sealed the dream day when he secured the king of the mountains prize, with Manning four points back in second.
But the day belonged to Feillu, and the Agritubel rider paid tribute to the rest of his six-man team for helping him achieve the biggest win of his career.
"After I won the first sprint I knew I was in a great position and my team worked so hard for me," he said.
"It was really tight but I was kept up to date by the team who knew what was happening and I felt in control.
"It's a great win for the team and a huge honour for me to win the yellow jersey and now I've got to build on it."
What are these?


text: China Unicom has announced the availability of the new Motorola XT390. It is a dual-SIM Android 2.3 Gingerbread smartphone that features a vivid 3.5-inch touchscreen display for e-mail, social networking and streaming video. Available in black and champagne gold, the dual-SIM/dual-standby Motorola XT390 also provides a 3-megapixel digital camera, GPS, an 800 MHz processor, a 512MB of RAM and support for China Unicom's 3G network. China Unicom will release the Motorola XT390 in the near future for around $160. [Press Release]


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How monumental, though, that this wedding introduced us, for the first time as husbands, Mitch and cam.
Ninth: If cameron is elected, Obama will confront the first leader of a Serious Country who is younger than he is (cam is 43).
When cam Newton was being recruited, he at one point was leaning toward Mississippi State.
Eric was frustrated and it was getting late and all of a sudden he flips the cam switch.
Her cam is set up to frame her bed with a background decorated to match her red hair.
Their chief object of commerce is rosewood or "cam," which they send to the coast.
In Figure 264 a lever arm A and cam C are in one piece on a shaft.
It cam fra Lunnon, an' it's worth a deeal o' money, is that cat.
Figures 325 and 326 show the cam wrist plate and the cut-off mechanism.
The poor young chap wrung his hands, and says he: "I've killed her, Jakey, I've killed her—and she so cam."


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Shaped by the land and climate and further molded by the economy and markets, Lodi's agricultural landscape over the decades has evolved from grain to watermelons to grapes.
When settlers first tilled the land in northern San Joaquin County beginning in the 1850s, wheat was the main crop. Wheat was planted over huge acreages and farmed without irrigation. Northern San Joaquin County was part of California's "wheat belt" in those early days. Lodi's early farmers all grew grain as well as smaller plots of other crops including fruit orchards, vegetables and grapes.
But starting in the 1870s, competition from Midwest grain growers and overproduction locally caused wheat prices to drop. As more farmers settled here, farms became smaller, and farmers needed to find a more profitable crop.
A man named Northrup thought watermelons would grow well in Lodi. He convinced George Eddlemon, and the two men formed a partnership. They planted 80 acres of watermelons and became the first melon growers in Lodi, according to the story George Eddlemon's son, Adolph, told the Lodi News-Sentinel in 1956.
Some doubted whether watermelons would grow without irrigation. But the water table was still just a few feet below the surface, and the melons thrived.
In the 1880s Lodi's fame for its watermelons boomed. During summer harvest, the newspapers carried frequent boastful stories greatly embellished about the fertility of Lodi's crop. Town leaders proudly proclaimed that Lodi was the "Watermelon Capital of the World."
But the lucrative watermelon crop began to sour in the late 1890s. Like the grain market a couple of decades earlier, the market for Lodi melons fell.
The underground water table dropped, and dry farming was no longer productive. Efforts to build irrigation systems and capture water from the Mokelumne River were just beginning at that time. Another blow to the watermelon industry included an infiltration of pollen from squash plants that caused problems to the crop.
Lodi melons also lost market appeal because melons grown further south ripened earlier. Newspapers urged Lodi's beleaguered farmers to change their course, switch crops and develop irrigation systems.
Riding the waves of boom and bust from grain to watermelons, Lodi farmers needed to find another profitable crop. Grapes, grown in small acreages in the region since the 1850s, became Lodi's salvation.
Farmers tried other crops but none excelled like grapes. For instance, in the late 1880s, one man planted 2 1/2 acres of mission, black prince and muscat grapes. The grapes produced a fine profit of $100 per acre. His 2 and 1/2 acre vineyard was worth $2,500, a very impressive figure for those days. This man's story, reported in the local newspaper, undoubtedly helped convince some farmers to switch crops.
Several different varieties did well in Lodi, but zinfandel and the tokay excelled. Farmers especially embraced the tokay. The tokay, an attractive, red grape with an eye-catching color, thrived in Lodi's sandy soil where the hot summer days are offset by cool night breezes from the Delta. Lodi's conditions were so perfect for the tokay that eventually 95 percent of the world's tokays were grown here. The versatile tokay was a good table grape that held up well during the long rail trip across country to the fresh markets in the Midwest and East. The tokay also could be crushed into sweet wines.
By the late 1890s and early 1900s, Lodi farmers began digging up watermelon fields and planting grapes, especially the tokay. In smaller acreages, farmers also planted fruit trees including peaches and cherries.
As more farmers saw the value of water-hungry grapes, the need for dependable irrigation became apparent. The Lodi Sentinel in 1901 wrote that irrigation was an "accepted fact." Henderson Brothers Hardware and Cary Brothers were busy installing windmills and pumps to draw water from the dropping underground water table on farms throughout the area.
In October 1901, there were five train carloads of wine grapes and 20 carloads of table grapes sent east in one week.
"Conditions were hard before we started raising grapes in the 1900s. No one noticed it especially because everyone was struggling. When we started planting grapes, everything seemed to pick up," Adolph Eddlemon told the newspaper.
After the turn of the new century, Lodi farmers who switched to grapes prospered again. Grape packing and shipping companies and wineries began sprouting up. Lodi was producing 25 percent of the state's table and wine grapes.
In 1901, the local newspaper stated that wine production was "the coming industry for this part of the state." A Stockton newspaper reporter in 1905 wrote, "Owners of such vineyards declare that they have no reason to envy the hard-working presidents of life insurance companies."
Lodi proudly called itself the "Tokay Capital of the World."
For the next several decades Lodi farmers mostly produced tokay grapes for the fresh market. Men picked the grapes by hand, laid them in large crates. The crates were hauled to the packing sheds that usually were located next to the railroad tracks. Women then clipped the grape bunches and gently packed them in attractive baskets placed inside wood boxes. They were loaded into rail cars and shipped east to market.
But the tokay was also a wine grape, and wineries began appearing in Lodi after 1900.
Lodi's grape industry survived the Prohibition years in the 1920s and actually prospered because the fresh market still demanded grapes.
After the Repeal of Prohibition in 1933, the winery business in Lodi escalated. By 1940, there were 18 wineries in the Lodi area that crushed more than 20 percent of the state's total wine production. Lodi also was ranked first in the state's fresh table grape shipments.
The wines made then were sweet dessert wines like sherry, port and champagne from tokays. In addition to being known as the "Tokay Capital of the World", Lodi also called itself, "America's Sherryland".
Then in the 1960s, consumer tastes changed. People moved away from dessert wines and preferred table wines, like bulk reds and whites, and later quality varietal wines.
The last straw for the tokay was the development of the Flame Seedless grape. Consumers turned away from the tokay with its seeds. With both the fresh and wine markets depressed for tokays, Lodi farmers planted other varieties. The zinfandel grapes, already well established, and other varieties like cabernet sauvignon, chardonnay and merlot were in demand for wine.
In 1986, Lodi's wine industry and transition to premium varietal grapes got a credibility boost when this viticulture area was recognized officially as an appellation. Then wineries were able to label their wines with Lodi listed as the grapes' origin. Lodi started becoming known for it's quality wine and called itself the "Zinfandel Capital of the World."
Today, with more than 80 wineries and more than 100,000 acres planted in premium varieties, Lodi's famed product of wine grapes is firmly planted in the soil.


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CSExtra – Wednesday, February 13, 2013
To subscribe to CSExtra via RSS feed click here.
If you would prefer to receive CSExtra in e-mail format, e-mail us at [email protected] with the word SUBSCRIBE in the subject line.
Wednesday's CSExtra offers the latest reporting and commentary on space related activities from around the world. NASA's Orion/Multipurpose Crew Vehicle clears a parachute recovery system milestone. Asteroid 2012 DA14, which is on course to skim past the Earth on Friday, earns an impressive price tag. Legislators from two key space states secure more influence on U. S. Senate panels with responsibility for NASA oversight. Congressional efforts to ease export controls sought by satellite manufacturers remain a work in progress. Russian investigators pinpoint the cause of a December Proton Breeze M upper stage mishap. NASA's Solar Dynamics Observatory unmasks a solar fury. Longtime British space correspondent Reginald Turnill has died. NASA's Mohawk Guy sports a new hair style for President Obama's State of the Union Address. Google snares a Mars rover driver.
1. From AmericaSpace.com: The parachute recovery system for NASA's Orion capsule demonstrates robustness in an Arizona drop test this week. NASA awards California-based Ares Technical Service Corp., a contract to support integration requirements for the four person spacecraft that is to serve as a cornerstone of future U. S. human deep space exploration plans. http://www.americaspace.com/?p=31289.
A. From Space.com: NASA's Orion capsule is a key to a future human mission to Mars, say those preparing a prototype for a 2014 unpiloted test mission. http://www.space.com/19749-orion-spacecraft-nasa-manned-missions.html
B. From The Huffington Post: Is there a Mars Generation? They may be everywhere among us. http://www.huffingtonpost.com/chris-carberry/enter-the-mars-generation_b_2668861.html
2. From Space.com: Deep Space Industries, the new asteroid mining start up, places the value of Asteroid 2012 DA14 at nearly $200 billion in recoverable water and metals. The 150 foot long space rock is on course to skim past the Earth on Friday. http://www.space.com/19758-asteroid-worth-billions-2012-da14-flyby.html
A. From The Washington Post: Asteroid 2012 DA14 is on course to skim within 17,000 miles of the Earth on Friday. The Post poses the question: Why aren't the world's innovators working on a strategy to fend off a future asteroid that might slam into the planet with devastating consequences? http://www.washingtonpost.com/blogs/innovations/post/why-youre-not-working-on-an-asteroid-shield/2013/02/11/20068686-7190-11e2-ac36-3d8d9dcaa2e2_blog.html
B. From Discovery.com: Asteroid 2012 DA14′s 's brush with Earth will occur between the orbits of crucial communications and GPS satellites. The spacecraft do not appear to be at risk of impact by the space rock, say NASA experts. http://news.discovery.com/space/asteroids-meteors-meteorites/asteroid-2012-da14-satellite-collision-130213.htm
C. From USA Today: Another worrisome collision threat, this one from Asteroid 2012 YQ1 in 2106, now looks less likely, say U. S. astronomers. Some Russian astronomers suggest otherwise. http://www.usatoday.com/story/tech/sciencefair/2013/02/12/asteroid-2106-relax/1914255/
D. From The Los Angeles Times: Several Internet organizations plan online coverage of Asteroid DA14′s close approach on Friday. http://herocomplex.latimes.com/video/asteroid-flyby-online/#/0
3. From Spacepolicyonline.com: U. S. Sen. Barbara Mikulsk, a Maryland Democrat, will retain her chairmanship of the Senate Appropriations Commerce-Justice-Science (CJS) subcommittee in addition to her new duties as chair of the full appropriations committee. Similarly, Senator Richard Shelby, the Alabama Republican , will pull double duty as top Republican of the full committee and the CJS subcommittee. The veteran lawmakers represent states that host the Goddard Space Flight Center and the Marshall Space Flight Center. http://www.spacepolicyonline.com/news/senate-appropriations-committee-announces-subcommittee-assignments-for-113th-congress
4. From Spacepolictics.com: Congressional efforts to redefine, ease export controls on U. S. satellites remain a work in progress in spite of an ease up in December. http://www.spacepolitics.com/2013/02/12/the-world-series-of-export-control-reform-is-yet-to-come/
5. From Spaceflightnow.com: Russian investigators point to a turbo pump bearing failure as the cause of a Proton Breeze M upper stage failure in December. The failure prompted the loss of a Russian energy company communications satellite. Launchings are scheduled to resume in March. http://www.spaceflightnow.com/proton/yamal402/130212frob/#.URry0B1_F48
6. From Discovery.com: A look at the imagery generated by NASA's Solar Dynamics Observatory mission — launched three years ago. The sun's ups and downs influence the Earth's climate and weather. http://news.discovery.com/space/astronomy/nasa-sdo-solar-sun-favorite-pictures-130212.htm
7. From Astronomy Now: Longtime BBC aerospace space correspondent Reginald Turnill has passed away. He died Monday at 97, the website reports. Turnill shuttled between the U. S. and former Soviet Union in the earliest days of human spaceflight. http://astronomynow.com/news/n1302/12reg/#.URtlGh1_F48
8. From the New York Times: The Mohawk Guy, aka Bobak Ferdowsi, alters his now famous hair style for Tuesday night's State of the Union address. On one side a tribute to the USA; on the other a tribute to Mars. Ferdowsi energized NASA's Mission Control room at the Jet Propulsion Laboratory on Aug. 5-6 as NASA's Mars Curiosity rover touched down for a two year mission. http://thecaucus.blogs.nytimes.com/2013/02/12/for-sciences-sake-its-mohawk-guy/?ref=science
9. From CNN: Mars rover driver Scott Maxwell departs NASA's Jet Propulsion Laboratory for Google. Maxwell will take his software writing skills with him. http://lightyears.blogs.cnn.com/2013/02/12/mars-rover-driver-leaves-the-steering-wheel/?hpt=us_t2
Brought to you by the Coalition for Space Exploration, CSExtra is a daily compilation of space industry news selected from hundreds of online media resources. The Coalition is not the author or reporter of any of the stories appearing in CSExtra and does not control and is not responsible for the content of any of these stories. The content available through CSExtra contains links to other websites and domains which are wholly independent of the Coalition, and the Coalition makes no representation or warranty as to the accuracy, completeness or authenticity of the information contained in any such site or domain and does not pre-screen or approve any content. The Coalition does not endorse or receive any type of compensation from the included media outlets and is not responsible or liable in any way for any content of CSExtra or for any loss, damage or injury incurred as a result of any content appearing in CSExtra. For information on the Coalition, visit www.spacecoalition.com or contact us via e-mail at [email protected].


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In addition to warming our brains and framing our faces, hair also provides the only concrete evidence of the existence of wind. Maintain your breeze detectors with this Groupon.
Choose from Three Options
- $29 for a haircut, deep-conditioning treatment, and blowout (up to a $65 value)
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- $59 for a haircut, partial highlights, deep-conditioning treatment, and blowout (up to a $145 value)
Salon Deja Vu
Salon Deja Vu cultivates an environment that's reminiscent of a family home, right down to the complimentary cups of coffee and friendly conversations about today's going allowance rates. When they aren't refreshing appearances with mani-pedis, waxings, or haircuts, the staffers at Salon Deja Vu focus their attention on several charitable efforts, including the Natural Fiber Oil Spill Booms program, a foundation devoted to keeping waterways clean. The salon's efforts have recently earned them the Daily Record's 2012 Morris County Reader's Choice Award for Best of the Best Hair Salon.


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Home & Education Software
Recon Calc
Recon-Calc is a source code feature location tool based on the Software Reconnaissance technique. It allows you to name features of your system and then, based on coverage profiles gathered, you can find where they are implemented in the source code.
Wizard's Kid-Safe LiveCD
The Kid-Safe system is designed to be installed on PCLinuxOS. The project's primary goal is the Kid-Safe LiveCD, which is built using this package. The system includes KDE Kiosk Restrictions, Internet Filtering, Games and More. Designed for all ages.


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This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
Information manifests a reduction in uncertainty or indeterminacy. As such it can emerge in two ways: by measurement, which involves the intentional choices of an observer; or more generally, by development, which involves systemically mutual ('self-organizing') processes that break symmetry. The developmental emergence of information is most obvious in ontogeny, but pertains as well to the evolution of ecosystems and abiotic dissipative structures. In this review, a seminal, well-characterized ontogenetic paradigm—the sea urchin embryo—is used to show how cybernetic causality engenders the developmental emergence of biological information at multiple hierarchical levels of organization. The relevance of information theory to developmental genomics is also discussed.
In colloquial usage
Indeterminacy is related to statistical randomness, and hence to the concept of entropy developed by Ludwig Boltzmann to explain the 2nd law of thermodynamics, and later by Claude Shannon to quantify the capacity of a noisy communication channel to transmit information. The higher a system's entropy, the more uncertain are the microstates or outcomes of the system—in other words entropy quantifies a system's indeterminacy. Thus, if a system's entropy can be measured, any information that emerges within the system can be quantified as a decrease in that entropy.
From the foregoing it should be clear that information is a constraint on degrees of freedom, randomness or the production of entropy. As such it can emerge through measurements that reduce the uncertainty associated with the state or outcome of an observed process; or more generally, through symmetry breaking processes that locally reduce the indeterminacy of a system. A symmetry-breaking trajectory of change producing an increase in determinacy is commonly referred to as development; hence, in general, information emerges developmentally.
Development occurs within localized systems of interacting processes comprising nested levels of inclusiveness, and while it is initiated from the bottom-up (by way of growth) it is ultimately controlled from the top-down (by way of selection); it can thus be modeled hierarchically whenever enough information exists to locate a system [
The key to the heritable reproducibility of biological information is the DNA molecule: A complex polymer that, by virtue of its deoxyribose sugar backbone and double helical structure involving specific Watson and Crick base-pairs, is ideally suited to both storing and reproducing information. It is probable that early in the evolution of life this job was carried out by RNA and later co-opted by DNA [
The thesis of this review is that the developmental emergence of information is caused by feedback ('cybernetic causality'). This is obvious in organismal ontogeny, which will be the main focus of this review. However, it is also apparent in higher-level phenomena such as ecological succession, phylogenetic evolution, and perhaps even cosmology [
The sea urchin embryo has been a paradigm of developmental biology since the inception of experimental embryology as a research discipline in the late 19th century. The seminal experiment of Hans Driesch [
Sea urchin embryogenesis is illustrative of both the developmental origin of emergent information and the causal role of historical information in determining the outcome of development. If this sounds suspiciously circular, that's because it is: Development generally occurs via
The sea urchin embryo produces a bilaterally symmetric larval form known as a pluteus (
In the sea urchin embryo a graded distribution of maternal mitochondria often prefigures the secondary axis of the embryo, and contributes to activation of
The epigenetic circuit involving
The heritable reproducibility of ontogeny is explained by the fact that the
Developmental gene regulatory networks increase the determinacy of cell fate along the trajectory of ontogeny. The causality manifested by this system is cybernetic: Regulatory states specifying cell fate are maintained in mutually exclusive domains by a complex system of positive and negative feedback [
The developmental emergence of information via historically encoded logic occurs hierarchically. For ontogenetic systems it is reasonable to choose the cell as the focal level of the organizational hierarchy, since the cell is the fundamental unit of life, and ontogeny typically begins with a single cell (the zygote). As described above the fate of the cell is controlled by the genome housed within the cell nucleus, which reflexively engenders and responds to a succession of transient nuclear regulatory states via the developmental gene regulatory network described above. However, the regulatory state of the nucleus also depends on the location of the cell within the developing embryo, and on the environmental cues received by the cell because of that location. Some of these cues are provided by intercellular signals (such that provided by Nodal describe above), receipt of which changes the nuclear regulatory state by activating a latent regulatory protein (e.g., Smad2/3).
As development proceeds differentiated cells form tissues with definitive structural attributes. For example, many tissues are composed of epithelia wherein the cells are polarized along an apical-basal axis defined by the basal location of a collagen-containing extracellular matrix, and linked together with intercellular junctions, thus forming an integrated unit. Mechanical forces (e.g., stretching) experienced by the tissue-and hence by the cells within the tissue-influence the regulatory state within nucleus of each cell by activating latent regulatory proteins [
The thesis of this review is that, in general, information is a product of development, which locally reduces indeterminacy (breaks symmetry) via cybernetic causality (positive and negative feedback). The developmental production of information can be qualitatively inferred by considering the trajectory of ontogeny (
Recall that the indeterminacy of a system is represented statistically by its entropy:
In ontogeny, the outcome of the process of cell fate specification is differentiation, which at the molecular level manifests as a defined set of gene products present in a given cell, each of which is associated with a metabolic process occurring within the cell. For a multipotent stem or progenitor cell of indeterminate fate (
It is now possible to use deep RNA sequencing (RNAseq) to accurately measure the expression levels of all of a cell's genes, which allows us to express the entropy of gene expression as:
A characteristic of pluripotency that has received increasing attention is the relatively 'open' state of chromatin in progenitor cells compared to their differentiated descendents [
Information theory has also been put to fruitful use in modeling the development of cancer (e.g., [
Finally, in a very interesting recent study Francois and Siggia used an information theoretic measure to quantify fitness of computationally simulated developmental gene regulatory networks that were allowed to evolve in silico [
From a developmental perspective, the laws of physics can be viewed as historical information produced by the very early development of the universe following the big bang [
However the cybernetic cut was traversed, because it was, biology is essentially a science of semiotics: The prescriptive signification and teleonomic (goal-directed) use of historical information [
Indeed, the extent to which animals are evolvable might be understood by considering the structure of gene regulatory networks in terms of both modularity and pleiotropy [
It is thus reasonable to surmise that early during the development of life on earth, the accumulation of historical information—for example, as manifested by the 'depth' of gene regulatory networks— was shallower and less constraining—that is, life was less developmentally
Larval ontogeny of the sea urchin (Strongylocentrotus purpuratus), illustrating the developmental emergence of information. (a) 1 day old blastula (∼200 cells). (b) 3 day old pluteus (∼1000 cells). In contrast to the relatively nondescript blastula, which is essentially a simple hollow ball of ciliated epithelial cells (which however are at this stage molecularly differentiated, representing emergent information that establishes a preformed map of the pluteus body plan), the pluteus has multiple differentiated cell types (e.g., the red pigment cells) and a distinctive bilaterally symmetric anatomy that includes skeletal, digestive, nervous, and immune systems.
Epigenetic specification of the secondary (oral-aboral) axis of the sea urchin embryo via
A model of the gene regulatory network (GRN) underlying differentiation of oral and aboral ectoderm in the sea urchin embryo [
A simplified phylogenetic tree of animals with estimates of the approximate evolutionary divergence times (in millions of years before present [
I thank Kevin Peterson and Joel Graber for helpful comments and suggestions. The work in my laboratory reviewed here was funded by the NIH (R01 ES-016722).