text:
Low-Dose Fludarabine, Busulfan, and Anti-Thymocyte Globulin Followed By Donor Umbilical Cord Blood Transplant in Treating Patients With Advanced Hematologic Cancer
- Full Text View
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- How to Read a Study Record
RATIONALE: Giving chemotherapy before a donor umbilical cord blood transplant helps stop both the growth of cancer cells and the patient's immune system from rejecting the donor's stem cells. When the healthy stem cells from a donor are infused into the patient, they may help the patient's bone marrow make stem cells, red blood cells, white blood cells, and platelets. Sometimes the transplanted cells from a donor can make an immune response against the body's normal cells. Giving chemotherapy, such as fludarabine and busulfan, and antithymocyte globulin before transplant and tacrolimus and mycophenolate mofetil after transplant may stop this from happening.
PURPOSE: This clinical trial is studying how well giving low-dose fludarabine and busulfan together with anti-thymocyte globulin, followed by donor umbilical cord blood transplant works in treating patients with advanced hematologic cancer.
|Leukemia Lymphoma Multiple Myeloma and Plasma Cell Neoplasm Myelodysplastic Syndromes
|Biological: anti-thymocyte globulin Biological: sargramostim Drug: busulfan Drug: fludarabine phosphate Drug: mycophenolate mofetil Drug: tacrolimus Procedure: umbilical cord blood transplantation
|Study Type:
|Study Design:
|Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
|Official Title:
|Pilot Study of Reduced-Intensity Umbilical Cord Blood Transplantation in Adult Patients With Advanced Hematopoietic Malignancies
- Safety and Feasibility of donor cord blood transplant [ Time Frame: up to 36 months post transplant ]as determined by > 80% engraftment rate at day 180 and a < 50% transplant-related mortality rate at day 100
|Study Start Date:
|September 2004
|Study Completion Date:
|July 2009
|Primary Completion Date:
|July 2009 (Final data collection date for primary outcome measure)
|Assigned Interventions
|Experimental: cord blood transplant
|Biological: anti-thymocyte globulin Biological: sargramostim Drug: busulfan Drug: fludarabine phosphate Drug: mycophenolate mofetil Drug: tacrolimus Procedure: umbilical cord blood transplantation
Detailed Description:
- Assess the feasibility of performing umbilical cord blood transplants in older patients or younger infirm patients with advanced hematologic malignancies using a reduced-intensity preparative regimen, as determined by > 80% engraftment rate at day 180 and a < 50% transplant-related mortality rate at day 100.
- Describe the time to neutrophil and platelet recovery in patients treated with this regimen.
- Determine disease-specific, event-free, and overall survival rate at days 180 and 360.
- Determine the incidence, severity, and timing of acute and chronic graft-versus-host disease in patients treated with this regimen.
- Evaluate T-cell, B-cell, and natural killer cell recovery in patients treated with this regimen.
- Assess lineage-specific chimerism after transplantation and describe the contribution of each individual cord blood unit to post-transplantation hematopoiesis.
OUTLINE: This is a pilot study.
- Reduced-intensity preparative regimen: Patients receive fludarabine IV over 30 minutes on days -8 to -4, busulfan IV over 2 hours 4 times daily on days -4 and -3, and anti-thymocyte globulin IV over 6 hours on days -3 to -1.
- Allogeneic umbilical cord blood transplantation: Patients undergo allogeneic umbilical cord blood transplant on day 0. Patients receive sargramostim (GM-CSF) subcutaneously or IV beginning on day 7 and continuing until blood counts recover.
- Graft-versus-host disease (GVHD) prophylaxis: Patients receive tacrolimus IV continuously over 24 hours or orally (as tolerated) beginning on day -2 and continuing for approximately 9 months. Patients also receive oral mycophenolate mofetil twice daily on days 1-50.
After completion of study treatment, patients are followed periodically for 2 years.
PROJECTED ACCRUAL: A total of 10 patients will be accrued for this study.
|Ages Eligible for Study:
|18 Years to 70 Years (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Diagnosis of 1 of the following advanced hematologic malignancies:
Acute myeloid leukemia (AML) meeting the following criteria:
- Considered incurable with chemotherapy
- Marrow blasts ≤ 10% (may be achieved using standard chemotherapy regimen)
Meets any of the following criteria:
- High-risk cytogenetics (-7, -7q, -5, -5q, t(6,9), t(9,11), complex [≥ 3 abnormalities], Philadelphia chromosome positive [Ph+])
- AML evolved from prior myelodysplasia
- AML secondary to prior chemotherapy
- Failed to achieve remission
- In second or subsequent remission
- Refractory relapse
Myelodysplastic syndromes (MDS) meeting the following criteria:
Must have high-risk features, including any of the following:
- Intermediate-2 or high risk International Prognostic Scoring System (IPSS) score
- Chronic myelomonocytic leukemia
- Marrow blasts ≤ 20% (chemotherapy may be given to achieve target blast levels)
- No rapidly progressive disease
Acute lymphoblastic leukemia meeting the following criteria:
- Considered incurable with chemotherapy
Meets any of the following criteria:
- High-risk cytogenetics (Ph+, t(4,11), 11q23 abnormalities, or monosomy 7)
- Required > 1 induction course to achieve remission
- Failed to enter remission
- In second or subsequent remission
- Marrow blasts ≤ 10% (chemotherapy may be given to achieve target blast levels)
Chronic myelogenous leukemia (CML) meeting 1 of the following criteria:
- Chronic phase CML that failed imatinib mesylate therapy, as defined by progressive disease or failed to achieve a major cytogenetic response at 1 year after initiation of therapy
Accelerated phase CML meeting 1 of the following criteria:
- Failed to achieve a complete cytogenetic remission at 1 year after initiation of therapy
- Failed to achieve any cytogenetic response after 6 months of therapy
- Progressive disease, as demonstrated by worsening cytogenetic response in 2 consecutive analyses separated by 4 weeks
- In blast crisis with < 10% blasts in bone marrow
Multiple myeloma meeting the following criteria:
- Stage I-III disease
Meets any of the following criteria:
- In relapse after autologous transplantation
- Refractory to ≥ 2 prior conventional myeloma therapies
- Chromosome 13 abnormalities (may be enrolled at diagnosis or after initial progression)
The following subtypes are eligible:
- Diffuse large cell
- Follicular large cell
- Mantle cell
- Peripheral T-cell
- T-natural killer (T-NK) cell
- Hodgkin's lymphoma
- Must have progressed, recurred after prior therapy, or failed to respond to primary therapy
- Relapsed disease after autologous stem cell transplantation (SCT) allowed
Low-grade non-Hodgkin's lymphoma meeting 1 of the following criteria:
- Relapsed or refractory disease after ≥ 2 chemotherapy-based treatment regimens
- Relapsed after autologous SCT
Chronic lymphocytic leukemia
- Relapsed or refractory disease after ≥ 2 chemotherapy-based treatment regimens
- Relapsed after autologous SCT
Meets 1 of the following criteria:
- Age 55-70 years
Under age 55 and deemed ineligible for conventional high-dose chemotherapy, as indicated by any of the following:
- Poor cardiac function (i.e., LVEF < 40%)
- Poor pulmonary function (i.e., DLCO < 50%)
- Hepatic dysfunction
- Prior myeloablative therapy
- Not eligible for autologous SCT or conventional therapy
Umbilical cord blood donor available
- Matched at ≥ 4 of 6 HLA antigens (A, B, and DR)
- Has 1-3 units of umbilical cord blood available
- Must not have an HLA-identical or 1 antigen mismatched related donor or potential HLA-matched unrelated donor readily available NOTE: A new classification scheme for adult non-Hodgkin's lymphoma has been adopted by PDQ. The terminology of "indolent" or "aggressive" lymphoma will replace the former terminology of "low", "intermediate", or "high" grade lymphoma. However, this protocol uses the former terminology.
- ECOG performance status 0-2
- Creatinine clearance > 40 mL/min
- Creatinine < 2.0 mg/dL
- AST and alkaline phosphatase < 3 times upper limit of normal (ULN)
- Bilirubin < 2.0 mg/dL
Hepatitis C or active hepatitis B virus (HBV) allowed if ≤ grade 2 fibrosis and/or inflammation by liver biopsy
- Patients with history of HBV infection should be tested for hepatitis B epsilon (HBe) antigen, anti-HBe, and HBV DNA (quantitative)
- Patients with active HBV viral replication should receive antiviral therapy
- Ejection fraction > 30%
- Not pregnant or nursing
- Negative pregnancy test
- Fertile patients must use effective contraception
- No active infection requiring ongoing antibiotic treatment
- HIV negative
- See Disease Characteristics
Please refer to this study by its ClinicalTrials.gov identifier: NCT00301951
|United States, California
|UCSF Comprehensive Cancer Center
|San Francisco, California, United States, 94143-0324
|Principal Investigator:
|Thomas G. Martin, MD
|University of California, San Francisco
|Responsible Party:
|University of California, San Francisco
|ClinicalTrials.gov Identifier:
|NCT00301951 History of Changes
|Other Study ID Numbers:
|Study First Received:
|March 9, 2006
|Last Updated:
|June 30, 2015
Keywords provided by University of California, San Francisco:
adult acute myeloid leukemia with 11q23 (MLL) abnormalities
adult acute myeloid leukemia with inv(16)(p13;q22)
adult acute myeloid leukemia with t(15;17)(q22;q12)
adult acute myeloid leukemia with t(16;16)(p13;q22)
adult acute myeloid leukemia with t(8;21)(q22;q22)
accelerated phase chronic myelogenous leukemia
adult acute lymphoblastic leukemia in remission
adult acute myeloid leukemia in remission
angioimmunoblastic T-cell lymphoma
blastic phase chronic myelogenous leukemia
chronic myelomonocytic leukemia
chronic phase chronic myelogenous leukemia
de novo myelodysplastic syndromes
extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue
anaplastic large cell lymphoma
nodal marginal zone B-cell lymphoma
previously treated myelodysplastic syndromes
recurrent adult acute lymphoblastic leukemia
recurrent adult acute myeloid leukemia
recurrent adult T-cell leukemia/lymphoma
recurrent adult Hodgkin lymphoma
recurrent adult diffuse large cell lymphoma
recurrent cutaneous T-cell non-Hodgkin lymphoma
recurrent grade 1 follicular lymphoma
recurrent grade 2 follicular lymphoma
recurrent grade 3 follicular lymphoma
recurrent mantle cell lymphoma
recurrent marginal zone lymphoma
recurrent mycosis fungoides/Sezary syndrome
recurrent small lymphocytic lymphoma
Additional relevant MeSH terms:
Multiple Myeloma
Neoplasms, Plasma Cell
Myelodysplastic Syndromes
Neoplasms by Histologic Type
Lymphoproliferative Disorders
Lymphatic Diseases
Immunoproliferative Disorders
Immune System Diseases
Pathologic Processes
Hemostatic Disorders
Vascular Diseases
Cardiovascular Diseases
Blood Protein Disorders
Hematologic Diseases
Hemorrhagic Disorders
Bone Marrow Diseases
Precancerous Conditions
Fludarabine phosphate
Mycophenolate mofetil
Antilymphocyte Serum
ClinicalTrials.gov processed this record on July 19, 2017


text:
War On Whistleblowers: Free Press & the National Security State
War on Whistleblowers highlights the stories of four whistleblowers who noticed government wrong-doing and turned to the media to expose the abuse they discovered. In addition to their personal accounts, the film includes interviews with journalists and legal experts sharing their knowledge of the challenges whistleblowers face today.
Latest Press
10 Lessons on Making Movies from Brave New Films' Robert Greenwald: A Decade of Speaking Truth to Power
by Steven Rosenfeld for AlterNet Democratic:
Lies before waging war in Iraq. Deconstructing Fox News propaganda. Profiling Walmart's culture of greed. Outing bloody wartime profiteers. Introducing America to the Koch brothers. Revealing why whistleblowers matter. Profiling innocent drone victims.
Weekly Poll Update: 'What current issue is most important?'
By Marcie Gainer for Disinformation
Old Poll
Our first weekly poll was a relative success. In light of our soon-to-be released Boredom, we asked your opinions on one of the issues raised in the film. It seems the majority of you agree with director Albert Nerenberg's conclusion. The results are below:
Are Smart Phones Making Us More Bored?
- Yes (69%, 121 Votes)
- No (31%, 54 Votes)
Total Voters: 175
- See more at: http://disinfo.com/2014/07/weekly-poll-update-what-issue-most-important/#sthash.OZX1JmXJ.dpuf
Film in the Classroom: Introducing Brave New Educators
By Lauren Byrd for Wandering Educators.
Film has long been an integral part of our culture. We remember the films we grew up watching, the movies that touched us in some way, and what deeper truths about the human experience a film uncovered.
War on Whistleblowers: Free Press and the National Security State
By Rick Kisonak for Seven Days
Remember George W. Bush? Your memory might be hazy. He doesn't come around much anymore. During the last election, the Republican National Committee kept him locked in a room. These days he likes painting childlike self-portraits in the tub. And Lord knows that brush on his Crawford ranch isn't going to clear itself.

subset: commoncrawl


text:
Somebody's Mother
Copyright by Danny Hahlbohm. All rights reserved by the artist.
None offered a helping hand to her,
At last came out of the merry troop
Send Somebody's Mother
On To A Friend
Using Your Email Program
Fathers Hands Home | Contact Customer Service
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Inspirational Poems and Stories ® DeerLake Designs L L C


text:
Antonio Villaraigosa's blowout public goodbye party on Friday is shaping up to be a lot like his tenure -- a glitzy, Hollywood affair paid for by special interests and the city's proprietary departments that's more about his own ambition than leading the nation's second-largest city.
The Ultimate L.A. Block Party was cooked up ostensibly as an event of Heritage Month activities, but the top three billed stars of the show -- President Bill Clinton, Mayor Antonio Villaraigosa and Mayor-Elect Eric Garcetti -- make it clear that this is a political rally at its core. The purpose? Slap a coat of sparkly PR paint on the waning days of Villaraigosa's disappointing second term.
The quarter-million-dollar block party extending from Grand Park to City Hall is "free" for the public, meaning that Angelenos won't have to pay to attend the soiree on public land. (Even for the chance to see Clinton and hear Placido Domingo and the musical stylings of Mariachi master Pepe Aguilar, it's hard to imagine Angenelos paying to go.) But nothing in politics is truly free.
Though the bulk of the cost this event is being paid for by a variety of special interests, including Disney, Wells Fargo and Time Warner Cable, there is a cost to the city -- an estimated $75,000 for the police and street services needed to deal with crowds of people. In addition, the city's three proprietary (or money-making) departments -- the water and power utility, the airports and the ports -- are kicking in $5,000 each. That's small potatoes for the huge departments, but it's indicative of a trend that has frustrated Angelenos over the past decade: the use of the proprietary departments as slush funds by the mayor and City Council.
Villaraigosa didn't invent the tradition, though he has taken full advantage. During his term, millions in revenue have been transferred from the three proprietary departments into the general fund and into the pet projects and travel of the city's elected officials.
Remember all those trade missions the mayor took to Asia and Latin America with posses of supporters and other elected officials? The airport and ports departments made those trips possible. The DWP has been bled the worst, and this example has been the most excruciating for Angelenos because it came at a time of unprecedented rate hikes for water and power bills.
The combined $15,000 for the mayor's farewell base is chicken feed compared to the millions that have been siphoned from the city's three proprietaries during his tenure, but it stings all the same.
That may not be what Villaraigosa was hoping to leave L.A. with upon his departure from office; old habits die hard.


text:
|Cass Hayward is an Engineering Consultancy with a widely acknowledged capability in bridges, engaged to produce designs and to complement teams of construction experts. The Firm was formed in 1983 and founded on the Principals' extensive experience in design, fabrication and construction of steel and composite bridges. More than 350 bridges, comprising over 700 spans have been constructed to Cass Hayward designs.
Cass Hayward has earned a formidable reputation for innovative and competitive designs reflected in significant success with design:construct projects and has special skills in bridge installation engineering and temporary works design.
|Cass Hayward utilise comprehensive modern IT functions including CAD & FE facilities for high quality illustrations and advanced structural analysis.
|Browsing the pages of this web site will indicate the range of disciplines and experience offered by Cass Hayward.
Cass Hayward Consulting Engineers is a trading name of Cass Hayward LLP – a Limited Liability Partnership registered in Wales Number OC306859.The Registered Office is at York House, Welsh Street, Chepstow, NP16 5UW


text:
Bruker's Photoconductive Module for the Dimension Icon® Atomic Force Microscope (AFM) enables quantitative nanoscale electrical characterization of organic photovoltaics (OPVs) at the highest resolution. In addition, the module provides compatibility with both industry-standard Newport solar simulators for uniform sample illumination and Bruker's AFM Environmental Control 1ppm Turnkey accessory.
Building upon proprietary PeakForce TUNA™ nanoelectrical characterization and the Icon's industry-best AFM performance, this photoconductive atomic force microscopy (pcAFM) solution provides the highest resolution, most reliable photoconductivity mapping available for soft, fragile samples such as OPV materials.
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|forum-ambassadors to improve communication between forum users and developers
|"Roald (ubuntu_demon)"
|Mon, 08 Jan 2007 00:42:44 +0100
-----BEGIN PGP SIGNED MESSAGE----- Hash: SHA1 Hi, Several forum users have brainstormed about creating a forum ambassador team. This team is intended to improve communication between the forum users and ubuntu developers in way that is manageable for the developers. We have already incorporated some dev feedback during UDS-mtv. Currently we are at a phase were we can't improve the document much more by discussing about it among ourselves. We think this forum team can potentially be very helpful to Ubuntu. But for it to work we need your cooperation. The first thing we need is your (developer) feedback on this document. Please read the entire document. All feedback is welcome. Especially feedback regarding communication between us forum ambassadors and you developers. For example in what way should we report to you about interesting trends and wishes ? The document lives at : https://wiki.ubuntu.com/ForumAmbassadors Please add any comments you have in the comments section of the document. Discussion can also take place in ubuntu-devel-discuss in response to this email (please use reply-all). Regards, Roald (ubuntu_demon) on behalf of all who contributed to the forum-ambassadors idea. Now follows the summary of the current document : This document specifies how to improve communication (bugs, ideas, forum users feedback) between the forums and the developers. The idea is to elect Forum Ambassadors and/or have a special forum for this to help to improve communication. We will create a forum section on ubuntuforums.org where people can request help of the Forum Ambassadors or convey their opinions in a constructive, concise and useful way (see design). A team of Forum Ambassadors will connect to the developers to facilitate communication. We will use ambassadors to collect ideas, bugs and feedback from users. This team would probably connect to developers via a mailing list, with possibly some irc contact. This idea originated on the forums. This idea was originally by Aysiu but many people have contributed to this spec. The current forum discussion is here : [WWW] http://ubuntuforums.org/showthread.php?t=278375 Our intended target is that the Forum Ambassadors become a team like : [WWW] http://ubuntuforums.org/showthread.php?t=289810 (If this doesn't happen we will become a 3rd party section) -----BEGIN PGP SIGNATURE----- Version: GnuPG v1.4.3 (GNU/Linux) Comment: Using GnuPG with Mozilla - http://enigmail.mozdev.org iD8DBQFFoYV0adqpfxv/6LsRAsUGAJ9xMf8AQY7TpQ+R116dY4/LSatGWwCeOhUs qLPNj4r+IKx3kUwlpkaUiYY= =3pb7 -----END PGP SIGNATURE----- -- ubuntu-devel mailing list [email protected] Modify settings or unsubscribe at: https://lists.ubuntu.com/mailman/listinfo/ubuntu-devel
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Democracy Now! is a non-profit organization funded through individual donations and foundation
grants. We do not accept any corporate underwriting, advertising, or government support. Your support is vital to
sustain and grow Democracy Now!
Fmr. EPA Investigator Scott West: US Has Told BP "It Can Do Whatever It Wants and Won't Be Held Accountable"
3 Undocumented Immigrants Risk Deportation in Protest for Passage of DREAM Act
"Silencing the Whistleblowers": How Will Financial Reform Prevent Another Crash If Banks Subvert Their Warning Systems?
Democracy Now! is a 501(c)3 non-profit news organization. We do not accept funding from advertising, underwriting or government agencies. We rely on contributions from our viewers and listeners to do our work. Please do your part today.


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T-Mobile US, Inc., TMUS is in the exchange NASDAQ and its industry is Wireless Communications in the sector of Technology. Based in USA, T-Mobile US, Inc., TMUS has a market cap of 35321.16. Since its IPO date on the 4/19/2007, T-Mobile US, Inc., TMUS performance year to date is 11.40%. Today T-Mobile US, Inc., TMUS has gained 0.00%, with a current price of 43.58.
Ownership of the company is 0.40% for insider ownership while institutional ownership is 34.80%. The management of the company have seen the company have a payout ratio of 0.00%. Return of assets are at 2.00%, with return on investment at 4.00%.
In terms of debt levels and profit levels, T-Mobile US, Inc., TMUS is seeing a long-term debt/equity of 1.68. While Total debt/equity is 1.7. With a profit margin of 3.70%, this is combined with a gross margin of 55.50%, and operating margin of 9.30%. T-Mobile US, Inc. ability to meet debt levels, with a current ratio of 1.4, while the quick ratio is 1.3.
For the last year T-Mobile US, Inc., TMUS has seen a EPS growth of 172.30%. A performance for the year of 12.41%. The 52-week high is -1.25%, and the 52-week low is 31.15%. The average volume for T-Mobile US, Inc., TMUS is 0.
With a target price of 47.44, can T-Mobile US, Inc., TMUS reach this target? Looking at the value indicators of T-Mobile US, Inc., TMUS. T-Mobile US, Inc. has a P/E of 29.91 and a forward P/E of 23.34. Perhaps the more useful indicator than P/E, is PEG which has a value of 0.89. T-Mobile US, Inc. also has a P/S and a P/B of 1.07 and 2.09 respectively. For P/cash, T-Mobile US, Inc. has a value of 5.37, while it is 883.03 for P/free cash flow.
At the current price of 43.58, T-Mobile US, Inc. has a dividend yield of *TBA. We see a return on equity of 7.40%.
Looking more long-term T-Mobile US, Inc., is projected to get an EPS growth for the next five years of 33.54%. In the short-term an EPS growth of 45.18% in the next year is forecasted. This is after a EPS growth of 172.30% for this year and for the last five years a -5.20% growth has been seen.


text:
The Administration shares your desire for job creation and a strong national defense, but a Death Star isn't on the horizon. Here are a few reasons:
- The construction of the Death Star has been estimated to cost more than $850,000,000,000,000,000. We're working hard to reduce the deficit, not expand it.
- The Administration does not support blowing up planets.
- Why would we spend countless taxpayer dollars on a Death Star with a fundamental flaw that can be exploited by a one-man starship?
The White House Response To The Death Star Petition Is Amazing
Current Status: Blessed (1)
Seeded on Sat Jan 12, 2013 9:02 AM
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text:
Ob-Gyn questions? Ask a gynecologist online.
The complaints you have can be due to urinary tract infection.Certain risk factors which make more prone to UTI are kidney stones,narrowed urethra,not drinking enough fluids,sexual intercourse.You need complete urine examination along with urine culture (clean catch) to know the exact bacteria & then take the treatment accordingly.Antibiotics may be required..Also the risk factors are to be diagnosed.Take nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen 400mg from your counter.It will reduce the inflammation & pain.This is available without prescription.So I advice you to see a urologist. for the urine test & prescription medication accordingly.
Please click green ACCEPT BUTTON so I can be paid for assisting you. BONUS and Positive Feedback are always greatly appreciated.


text:
Why You CAN'T Leave Animals In Hot Cars!!!
Every year, dogs suffer and die when their guardians make the mistake of leaving them in a parked car—even for "just a minute"—while they run an errand. Parked cars are deathtraps for dogs: On a 78-degree day, the temperature inside a parked car can soar to between 100 and 120 degrees in just minutes, and on a 90-degree day, the interior temperature can reach as high as 160 degrees in less than 10 minutes.


text:
David Lacey
Memory Slips As Memory Fades - Poem by David Lacey
Alas I know not where to go, for all the places I know, I've been.
Alas I have been shown not where to go nor can I remember all I've seen.
Memory slips as memory fades as shades they flip exposed to flames.
As insects roast upon the embers of the fire,
A blaze trailed through the void of darkness,
Breathing destruction upon dry bone leaves,
Bearing down destruction upon well established trees.
The crown of the forest resides his power
Biding his time awaiting the shower of inferno
Gatherings as the elders race forever young towards
the fountain groves to quench their tongues
A new race has begun, another year of wondering
Aimlessly it seems trying to find a meaning etched
Within our dreams. These eyes grow tired each second past,
I'll try still I fear I'll never last
I fear I may have lain placid upon the grass too long.
That I may never come to see the day pass in death
Only to see life breathe anew by the dawn.
Born of rosy fingered bliss, born wild of the sweetest kiss.
Of this beauty I was never warned nor could I ever prepare
For confrontation with the Emerald Goddess of lust loved hair,
Or of raven queens, black ribbons sisters in distress,
How could we of know she was the devil's mistress?
How could we prepare?
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text:
The Bears filled another roster hole Friday when they re-signed kicker Connor Barth, a player special teams coordinator Jeff Rodgers and coach John Fox have faith in.
Barth was tabbed to replace Robbie Gould when the longtime veteran was released after the end of preseason last year. Indications last week were the team would work to bring Barth back and that happened, according to a league source. Barth's contract is for one year and worth $980,000 and includes $155,000 guaranteed.
The 30-year-old Barth was 18-for-23 on field goals (78.3 percent) last season and made 31 of 32 extra points. He averaged 62 yards on kickoffs with 26 touchbacks.
In 99 career games, Barth...


text:
Thursday, 31st January 2013
'Virtual Chimneys' reduce airport pollution
Tests see emissions cut by half
SIMPLE 'blast' fences called baffles could deliver improvements in air quality for people living near airports, new research has found.
Placed behind a runway, the baffles could serve as a 'virtual chimney', funnelling emissions from aircraft engines upwards where they can disperse more effectively, thereby reducing the environmental impact on people living nearby.
Prototype baffles have been tested by a team of researchers from Manchester Metropolitan University, Cranfield University, Southampton University and the University of Cambridge, with funding from the Engineering and Physical Sciences Research Council (EPSRC).
After preliminary wind tunnel testing of various baffle shapes carried out by Cranfield University, an array of three rows of baffles was tested using laser scanning (Lidar, which is the optical equivalent of Radar) and chemical sensor techniques at Cranfield Airport in Bedfordshire. This demonstrated that the aircraft exhaust plume could be made to leave the ground within the airport's boundary fence, using prototype baffles of less than a man's height and constructed out of low-cost agricultural windbreak netting on lightweight frames.
Fumes sucked skyward
Dr Mike Bennett, of MMU's Research Centre for Aviation and the Environment, who led the project, says: "Airfield surfaces are typically covered with grass, over which the wind can blow freely. An array of baffles makes the surface rough in an aerodynamic sense. This sucks the momentum out of the exhaust jet, allowing its natural buoyancy to come into play. By suitably angling the baffles, we can also give the exhaust an upwards push, encouraging it to rise away from the ground.
"The baffles we tested were tilted at angles between 40° and 60° in order to optimise this vertical flow – and to ensure the baffles didn't blow over! Although the exhaust will still disperse to the ground eventually, it will do so at a lower concentration. We might hope to see a reduction in surface concentrations of around 50 per cent at the perimeter fence behind the place where aircraft are taking off."
Long-term ground-level nitrogen dioxide (NO2) concentrations around many major airports in Europe already exceed the legal limit enforced by the EU.
The aim of the trial was essentially to test the baffles' aerodynamics. As the prototype installation was temporary, it was constructed very differently from how a permanent installation might be made. Each baffle must be sufficiently robust to withstand the 80-90 knot blast from a jet engine, but flimsy enough to collapse harmlessly if an aircraft were to hit it.
Cut in noise
In the trial, this was achieved by restricting the prototype baffle widths to about two metres but it would be feasible to make them much narrower in a permanent installation. For full-scale use an area of baffles in the order of a thousand square metres would need to be erected behind a runway.
The tests also showed that the baffles dampened engine noise downstream by a modest amount and were helpful in reducing jet blast on the airport perimeter.
"There's no reason why baffles couldn't start to be installed at airports within two or three years," Dr Bennett says. "From the point of view of local air quality, they represent a quick, cheap supplement to developing low-NOx jet engines."
The project was carried out under the auspices of the EPSRC-funded Airport Energy Technologies Network (AETN), which was established in 2008 to undertake cutting-edge research in the field of aviation.
Notes for Editors
The development of the baffles has taken place as part of the three year project 'A Study of Practical Abatement Techniques for Exhaust Jets from Commercial Aircraft', which concluded in the autumn of 2012 and received total EPSRC funding of £413,000. The University of Cambridge provided air quality monitoring expertise for the field tests. The Institute of Sound and Vibration Research in the University of Southampton carried out the acoustic studies.
The aircraft used in the field tests at Cranfield Airport was the Natural Environmental Research Council's (NERC) Facility for Airborne Atmospheric Measurements (www.faam.ac.uk/), a four-engined BAe146. The aircraft took off 12 times in all and on each occasion burned its engines for 5 -15 seconds at the end of the runway prior to take-off.
Lidar is the optical equivalent of radar. A pulsed ultra-violet laser beam was scanned through the exhaust plume in order to monitor the plume's dispersion.
The initial projects associated with the AETN were the outputs of an EPSRC Sandpit event in November 2009. Sandpits are intensive discussion forums where free thinking is encouraged in order to delve deep into specific issues and identify innovative solutions.
The Engineering and Physical Sciences Research Council (EPSRC) is the UK's main agency for funding research in engineering and physical sciences. EPSRC invests around £800 million a year in research and postgraduate training, to help the nation handle the next generation of technological change. The areas covered range from information technology to structural engineering, and mathematics to materials science. This research forms the basis for future economic development in the UK and improvements for everyone's health, lifestyle and culture. EPSRC works alongside other Research Councils with responsibility for other areas of research. The Research Councils work collectively on issues of common concern via Research Councils UK.
Manchester Metropolitan University is the largest campus-based undergraduate university in the UK, with a total student population of more than 37,000 and an emphasis on vocational education and employability. With a history dating back 150 years, it was awarded university status in 1992. http://www2.mmu.ac.uk/
Manchester Metropolitan University is one of the most extensive higher education centres in Europe with 37,000 students and more than 1,000 undergraduate, postgraduate and professional courses. The University educates and trains large numbers of legal and business professionals, scientists, engineers, teachers, health workers and creative professionals.
The University is in the top three nationally for environmental sustainability and has an 85% research impact rated world-leading and internationally excellent.


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My son is 11 (this week) and is unvaccinated. He has had a cough for over 2 weeks and on Friday was diagnosed with bronchitis and put on antibiotics. He is getting even worse and the last 3 days has been having horrible coughing fits that end in him vomiting. He has vomited 20+ times a day in the last 3 days from coughing. He is barely eating and has a low-grade fever. I am not hearing a whooping sound at all though. I am taking him back to the dr today but I am wondering if this sounds like it could be whooping cough? I don't know where he would have been exposed to it though.
Ask them to test for it! You don't have to hear the whoop for it to be Pertussis.
My children had contracted whooping cough last year and it lasted for ten weeks. The whooping sound didn't come about until around week three when the coughing became worse. My daughter was in preschool and from what I have learned after the fact, unvaccinated children whom attend public schools have been known to contract whooping cough by coming in contact with vaccinated children who have parapertussis as a result of their vaccination. The diagnosis of parapertussis in vaccinated children is often overlooked because it is assumed that if a child has been vaccinated, then they do not have it. This assumption is wrong!!
If it is pertussis, there are many things that I did for my children that helped us get through it. My children's doctor had no advice to offer about how to deal with pertussis so I had tried almost everything I could find until I found things that work. If you would like more info I will gladly share, as I created a whole folder to document what made it better or worse.
I hope your DS is feeling better soon and that it isn't pertusis. If it is, don't panic! My children made it through and are very healthy one year later. One last thing, antibiotics will NOT speed up recovery as this is an illness that must run its course. Taking an antibiotic will kill all of the good bacteria that could aid in helping your little man get better, which will delay the recovery.
The link provided is just one of the many about parapertussis and it's association to the pertussis vaccine. There are many more on the link's site. Even though you may not be able to naturally prevent your child from contracting a disease if you do not vaccinate, it is still very important to educate yourself so you can be prepared if you do encounter a situation where additional information is needed. The website listed is a goverment site and has a lot more information on many oter topics. I do most of my fact finding from this site. I hope you are able to gain something from it as well. :-)
Have you tried giving sodium ascorbate? That would be the first thing I would do with suspected pertussis.
It could also be flu. We have seen lots of it in my area, and all say the COUGH lasts forever and can be nasty. If it is a virus, it of course won't respond to antibiotics.
Some kids have sensitive gag too when it comes to a bad cough. They throw up from it. So sorry to hear how sick he has been, I hope it calms down soon.
We are pretty sure it is whooping cough. He is still having the bouts of coughing that end in vomitting. Between those bouts he seems fine. He already had 5 days of erythromycin when we thought it was bronchitis and they put him on an inhaler but it doesn't seem to help much. We're not going to bother getting a formal diagnosis because there is nothing more that can be done at this point but to wait it out.
My question now is how long to keep him out of school? According to everything I've read if they've had a course of erythromycin then they are not longer infectious. Is this accurate or not? I can't keep him out of school for the whole course of the cough because he will get really far behind (he is on an IEP and has multiple learning disabilities so school is quite hard for him). I would like to send him to school but if he has a coughing/vomiting fit I'm not sure how they would handle that.
As for treatment we are using a vaporizer in his room and giving him honey followed by warm water (recommended by a nurse on telehealth ontario). We are also letting him suck on menthol cough drops and I just bought a natural expectorant cough syrup I thought we could try. Other than that I'm not quite sure what to do. If it is whooping cough are my girls likely to get it at as well? They are also not vaccinated. My husband and I were vaccinated as children but haven't updated in years.
If he has already had the round of antibiotics then he shouldn't be passing it on to others. We had WC, and the ones that got antibiotics were pronounced fine to return to work, etc... once the course was finished. Someone else in the family might get it or maybe not. It is one of those things that only time will tell. We were a family of 4 when we got it, and everyone did end up with it.
Both my husband and I are starting to feel sick now. We'll know in a week or so I guess it is whooping cough. Right now we both have congestion, fatigue, starting to cough, low-grade fever off and on. The girls don't have any symptoms so far.
Hello, I hope your child is a lot better since suffering from whooping cough. What technique has you used. I really would like to know. I am open to any ideas. My daughter is 8, and it started off with a cough for 2 weeks, we were thinking it was her asthma acting up, and gave her breathing treatments etc. Now its going on 3 weeks with the coughing up phylem then all the food that she has eaten in that little time span. Please tell me what have you used to make your child better? Thank you,
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Looks like Alderbury Cove is no longer available on Rent.com which means this information is likely out of date.
This property is an income restricted property. A maximum income limitation may apply. Not all renters will qualify and other restrictions may apply. Please contact the property for details.
Full size washer and dryer included, private patios/balconies with storage, and a wood burning fireplace in each apartment, most carpets under a year old, carport included...all in a great central location!
Our property is conveniently located near Boise Towne Square, freeway access, public transportation routes, shopping, hospitals, schools, and restaurants. The beautiful grounds feature newly remodeled clubhouse, brand new fitness center, and brand new off leash dog park. Rent does not include water, sewer, trash; electric is also the responsibilty of the resident. Two minutes to Towne Square Mall and spacious floor plans centrally located 15 minutes from downtown. Most carpets are less than a year old and each apartment has a covered carport, washer/dryer, a wood burning fireplace, and private balconies with a storage closet.
Offering 6 months (at a premium), 11, and 12 month lease terms. Security Deposit is $300 on either floorplan, on approved credit. Pet Policy: 2 pet maximum, $20 pet rent for each pet, non-refundable pet fees: Cats $375 and Dogs $300. Breed restrictions apply. Call for restrictions.
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PAPERBACKSWAP.COM Ripoff Reports, Complaints, Reviews, Scams, Lawsuits and Frauds Reported
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1, Report #929379
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Strange, possibly crazy: acts birdy during her period
"We'd better get ready for another attack," birdy Edwards said.
But they looked "birdy," those fields, and the girl was making for them.
A birdy, ancient woman hovered about them with noises of concern.
I feel as if I had known you a long time, for birdy often spoke of you in her letters to me.
The loud, rattling, birdy whistle in the low trees during dull weather Yan had traced to the Tree-frog.
Indeed, the marsh was birdy—rich in numbers if not in species.
With a succession of shrill, birdy chirps the old otters warned their young.
Ben thought that was the tall girl; certainly she was the one who delivered that birdy whistle.
Pinkerton has taken hold under their orders, and his best man, birdy Edwards, is operating.
She sat down upon the step and held the birdy very tenderly till Bertie came back.


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The chemistry of carbon accounts for the formation and diversity of organic molecules, including carbohydrates, lipids, proteins, and nucleic acids.
Chapter Outline
In this chapter outline, the learning objectives and the selected key terms are given for each major head in the chapter.
Cells Contain Organic Molecules (p. 43)
Simple Sugars to Polysaccharides (p. 45)
Fatty Acids to Lipids (p. 48)
Amino Acids to Proteins (p. 52)
Nucleotides to Nucleic Acids (p. 56)


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We will be revising these labs over next year or so, suggestions welcome
What is Science
A considering of what makes science different, and how science works in practice.
In Water
An introduction to the properties of water, its behavior as a function of temperature, and the diffusion of particles (Brownian motion).
Can be expanded through the use of the vScope to a more mathematical analysis of molecular movements and their role in biological systems.
Introduction to E.coli
An introduction to the basic techniques for handling bacteria in the lab, including dilution and the measure of cellular growth using both light scattering and plating.
On Growth
Characterization of bacterial growth as a function of temperature and bacterial survival as a function of time. Provides a context for both Mutation and Adaptation labs.
On Mutation
An introduction to bacterial viruses and how they were used by Luria and Delbruck to distinguish between the selection of pre-existing mutations (Darwinian) or the induction specific traits (Lemarkian) processes.
The lab introduces the types of changes that lead to resistance, and could be expanded in this direction, to address questions of viral adaptation to host and visa versa.
On Adaptation
: A study of how bacteria adapt to various environment conditions.
future lab expansion into ecological and evolutionary issues associated with niches and speciation.
On Networks
An exploration of emergent behavior from simple gene regulatory networks - in development and not yet available.


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The ProLux is HOPE Orthopedic's string-pull mechanical advantage
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Read the full story here Web Link posted Wednesday, October 24, 2007, 12:00 AM
Town Square
Atherton: King family drops lawsuit, will keep Tallwood house, for a price
Original post made on Oct 24, 2007
Read the full story here Web Link posted Wednesday, October 24, 2007, 12:00 AM
Comments (4)
a resident of Atherton: West Atherton
on Oct 24, 2007 at 9:32 am
I want to compliment the Almanac on their web site design, which allows for additional comments to be added to stories. I believe the reporters do a great job dealing with all the statements from the various people involved to report both sides of a story and deal with the space limitations of a printed paper.
Here are additional details to the Kings' Tallwood home that readers may find interesting and which have lead to my opinions and votes on this home.
In Atherton the limit as to how many square feet a home can be built is a ratio of the lot size. Unless a basement is more than 2' above the average natural grade of a lot it does not count; so homes are designed for the basements to be under that 2' threshold.
Our Zoning code 17.08.054 created in 1998 on Basements reads: "For the purpose of this chapter, "basement" means that story below the "finished floor of the first story" of a building that is in no point in excess of two feet in height above the surrounding average natural grade. Basements are subject to the requirements of Section 17.36.190.
In Woodside a basement is defined as: The improved or unimproved portions of a building which are fully or partially below grade so that the vertical distance from the "ceiling to the grade of the adjoining ground" is no more than two feet above grade.
In Atherton we add the foundation of the first floor (approximately 16") to the height of the basement compared to Woodside. I proposed at the June council meeting when we were changing the Basement ordinance back to 2001 standards to allow basements under accessory structures that we also change the point of reference. That change would have meant that the King's basement would not count towards FAR and there would be no issues.
My suggestion was tabled till next year when the consultant's report on updating our General Plan is done. Last year City Manager Jim Robinson brought in Gary Binger from the Association of Bay Area Governments (ABAG) to review Building Dept issues. Mr. Binger concluded that the Atherton Zoning Code and been changed frequently during the last 20 years, causing the Building official to make interpretations on many jobs as to what was "Grandfathered" and acceptable and what was not, how and when to apply new rules, and how to deal with contradictions in the codes, etc…
When I reviewed the facts on the King's home this is what I found.
1. During his Phase Three Audit report in October 2006, Finance Director John Johns reported the home to be 2,500 square over FAR. In February he reduced his number to 1800, but these were both miscalculations and the home is 1183 square feet over FAR when the basement is counted. One of Mr. Johns errors was under calculating the lot size. I have presented that a flaw of the audits was having a Finance Director interpret building codes, without getting a second opinion.
2. The home across the street from the Kings, which was built many years ago before the 1998 changes, looks the same as the Kings. Early in the process those residents asked the council to drop the abatement against the Kings.
3. At times due to work flow, the Atherton Building Dept will use contract plan checkers; this was the case on the Kings property. When the plans were submitted to the contract plan checker, he did not do a physical takeoff of the square footage, he also he not notice and did not advise the homeowner the basement would count towards FAR as it would be above the 2' height threshold.
4. The King's house sits on top a hill with a steep drop-off at the front. The house is not over the height limitations for Atherton. Had the Plan Checker advised them of the basement issue, they could have removed 16" of topsoil to lower the finished first floor and the basement would not have counted. This is a costly solution for the Town of Atherton, the Environment, the Kings, and their neighbors. Many truckloads of dirt would put wear and tear on our roads, the neighbors have to deal with the off haul, the off-haul dirt adds to landfills, and the Kings get the bill.
5. Shortly before the home was to be completed in December of 2006, the FAR problem was noticed and the Building Dept advised not to issue a certificate of occupancy. At the council meeting of October 17, 2007 Mr. King reported that he then offered to pay the Town the fees as if the basement square footage would be part of FAR, approximately $10,000 to settle. He reported this offer was declined.
6. In February 2007 an Abatement Notice was issued by a 4-1 council vote (I opposed) and both sides began legal expenses.
7. On October 17, 2006 the council offered Mr. King to settle for paying the square footage fees.
8. Many residents have contacted me during this issue. I have suggested the residents West of Alameda come to the council meeting when the consultant's report on our General Plan is presented. Back in 1998 when this basement ordinance was written, there probably was no one from West of the Alameda on the General Plan, the Planning Commission, nor the City Council to press they concerns. Adding the phrase "Basement height is measured to the ceiling" to the Atherton ordinance will solve many problems in the future for residents West of the Alameda.
Charles Marsala
Council Member
a resident of Atherton: other
on Oct 26, 2007 at 2:52 pm
I would like to respond to some of Mr. Marsala's comments – reproduced below – with my comments to follow:
"3. At times due to work flow, the Atherton Building Dept will use contract plan checkers; this was the case on the Kings property. When the plans were submitted to the contract plan checker, he did not do a physical takeoff of the square footage, he also he not notice and did not advise the homeowner the basement would count towards FAR as it would be above the 2' height threshold."
"4. The King's house sits on top a hill with a steep drop-off at the front. The house is not over the height limitations for Atherton. Had the Plan Checker advised them of the basement issue, they could have removed 16" of topsoil to lower the finished first floor and the basement would not have counted. This is a costly solution for the Town of Atherton, the Environment, the Kings, and their neighbors. Many truckloads of dirt would put wear and tear on our roads, the neighbors have to deal with the off haul, the off-haul dirt adds to landfills, and the Kings get the bill."
With all due respect to Councilman Marsala, I find it necessary to clarify misrepresentations of fact presented in the above statements regarding the Plan Review process, my level of expertise regarding Zoning Ordinance at the time of the review, and the authority with which I was empowered. I want to be clear that there is no way Mr. Marsala could have been aware of the realities I am about to describe without discussing them with one or more of the many witnesses to or participants in these events.
Mr. Marsala's statement in Item #3 of his comments "When the plans were submitted to the contract plan checker, he did not do a physical takeoff of the square footage,…" is not factually accurate. The First Review Report of the property, word processed on April 18, 2005 contains a complete Building Square Footage review, and the hand-written tabulations in my file confirm that this review was performed.
The statement in Item #3: "he also did not notice that and did not advise the homeowner that the basement would count towards the FAR as it would be above the 2' height threshold." requires further contextual explication.
At the time the Building Official, Mike Hood, saw fit to assign this job to me I had a total of 140 hours of experience performing plan check or about 4.5 full time weeks over a period of 5 months. In the presence of multiple witnesses, Mr. Hood read every word of every report I ever wrote from the date of my hire in November, 2004 to the date of his retirement on July 1, 2006. No comment, calculation or zoning determination was issued or communicated at any point without his express awareness and approval.
In Building Departments, the dispensations of the Building Official are legally valid. No subordinate has the authority to unilaterally reverse or disregard the Building Official's dispensations, and all subordinates function as agents of his authority and dispensations.
Regarding the failure to notify the owner of the condition of the Finish First Floor height relative to Average Natural Grade, Mr. Hood was entirely aware of the facts of the proposal relevant to Zoning issues.
Additionally, regarding the determination of Average Natural Grade, in the First Review Report, I sent to the client an Average Natural Grade determination of 349.5. This ANG was calculated by Mr. Hood in our First Review meeting using a six reference point basis for determination. In response to Plan check, the Client's engineer faxed a letter to the Building Department using 30 points of reference which included points around the Cabana location upslope of the Main Residence. The concept of this use of points around the Cabana was that the Cabana was, for the purposes of determining ANG, regarded as part of the Main Residence. However, for the purposes of determining Floor Area, the Cabana was regarded as a separate structure, an apparent logical inconsistency.
The letter faxed by the engineer remains in the file, and in the possession of the auditors.
Prior to my writing the Second Review Report, Mr. Hood showed me the fax and informed me that the ANG proposed by the client was to be implemented. The new ANG was to be 351.1, or 1.6 feet higher than that determined by Mr. Hood in our previous meeting.
To the best of my recollection, at no time in my experience working with Mr. Hood on any project over a period of over 1 and one-half years, were more than 6 reference points used in the determination of Average Natural Grade, and there was never another instance when a client dictated to the Department what the Average Natural Grade would be.
Subsequent to this meeting, the following is the note in my Second Review Report regarding Building Heights:
"The Re-submittal Letter calls for a height increase from the Town of Atherton's determination of ANG of 349.5 to a value of 351.1, an increase of 1.6 ft. In addition, the Re-submittal Letter calls for an allowance of height increase of 1' for a setback increase of 1' 6". Chapter 17.20.010.A.a of the Zoning Ordinance allows for a ratio of 1' per 5' of setback increase to a limit of 34'. A set back increase of 1' 6" would create an allowable additional height increase of 0.3 feet. If the Average Natural Grade increase from 349.5 to 351.1 is approved, the final allowable ANG would be 351.1 and the allowable maximum Building Height would be 381.4. The proposed Building Height is 381."
In summary, I know that Mr. Marsala is well-intentioned in his comments. Both he and anyone else who is familiar with the situation ought to have compassion for the considerable disruption and distress the owners have had to endure, and compassion is never wrong. However, assigning responsibility for occurrences to the appropriately empowered authority is as important as having concern for others.
a resident of Menlo Park: Stanford Hills
on Sep 30, 2008 at 4:49 pm
who cares his house is huge so wut give him a break
a resident of Menlo Park: Suburban Park/Lorelei Manor/Flood Park Triangle
on Jun 4, 2017 at 8:00 am
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CMU Stories & Research
Sealed With Love
Her clients include Tiffany & Company, Estée Lauder, The New Yorker and others, but this month, her heart was with the U.S. Postal Service.
Alumna Elizabeth Q. Cassetti designed this year's limited edition Love stamp.
"Cut Paper Heart" was inspired by folk art traditions. Cassetti — whose portfolio includes hundreds of valentines — finds inspiration in many forms, including Andrew Carnegie.
See her Carnegie-inspired valentine design »
Counting Counts
Want to improve a young child's early number skills? Break out the board games.
A study co-published by CMU Professor Robert Siegler finds that parents can make a small change in playing board games with numbered spaces to increase children's learning.
It's all in the counting method.
The findings were published shortly after CMU launched the Simon Initiative to accelerate the use of learning science and technology to improve student learning.
Learn the best way to count with kids »
Walt Disney Imagineering
Imagine magical, whispering trees in Thailand and Peru that allow people to talk to each other half a world apart.
This idea, part of a project titled "Antipode," earned CMU students the top prize in a Walt Disney Imagineering competition.
Teams were tasked with selecting large, densely populated urban areas and designing an experience for the enjoyment of residents and visitors.
The CMU students proposed a two-week cultural exchange festival unfolding simultaneously in Bangkok, Thailand, and Lima, Peru, where trees serve as portals between the two cities.
Read more about the Disney competition and winning CMU project »
Project InMind
Yahoo and CMU have announced a five-year, $10 million partnership.
Called Project InMind, it will allow CMU researchers to use Yahoo's real-world data as they develop personalized mobile applications.
InMind will use artificial intelligence techniques to automatically learn the needs and preferences of its users, enabling it to anticipate what information mobile users need and to provide that information when and where they need it.
Hear more about the project and partnership (video) »
News & Events
Networking Events: CMU Connect in DC & San Fran
Carnival, April 10-12: Celebrating 100 Years
Commencement, May 18
School of Drama 100 Years: Tell Your Story, Share Your Memories
World Economic Forum: CMU Makes Top 10 Emerging Technologies for 2014
CMU News: President Emeritus & University Professor Jared L. Cohon Named Director of Wilton E. Scott Institute for Energy Innovation
NBC News: Broadway Bots: Robots Take Lead Roles in Drama, Standup
NPR: Does More Convenience Mean Less Privacy?
Politico: The Robots That Saved Pittsburgh
CNN Money: Duolingo, the language learning service, raises $20 million
New York Daily News: Black History: 'Amazing times' on Broadway
Technology Review: Storing the Sun
Chicago Tribune: Attack on California electric grid raises alarm
Popular on Social Media


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Pasadena Restaurant Reviews
Welcome to our Pasadena restaurant reviews guide where you'll find top restaurants off the beaten path, both locally owned and chain. In fact, some of the best restaurants in the Pasadena just might be the little mom and pop operations flying under the radar. For some of the best picks in Pasadena, you've come to the right place.
Our Pasadena restaurant reviews guide can help you make sense of the thousands of options out there. Happy eating!
Also check out our Best Restaurants in Pasadena 2016 Guide
Displaying 1 - 20 of 31
Panaderia y Restaurante La Favorita(01/24/2014)
"First time trying their pupusas and it left me wanting some more. My hubby is out getting me some. Oh and the agua de frutas is soooooo goood!!!"
OISHII - Thai/Japanese Cuisine & Sushi Bar and Grill(10/01/2011)
"I have been eating at this restaurant since December 2010, and it's hard to believe that people aren't lined up outside waiting to get in. Perhaps potential customers are confused by what is meant by "Thai-Japanese Cuisine." Simply put, one can order Thai AND Japanese cuisine here, and one will be... "
O2 Sushi(06/14/2011)
"Went there for lunch and the food was excellent and a good price. Like the vegetables used in their tempura are huge and very good. Their spicy tuna rolls are very very tasty. I'm surprised I haven't heard about them because me & my friends frequent Japanese restaurants, but now I know!!!"
Heidar Baba(03/08/2011)
"I went to Heidar Baba last week with my husband and family to celebrate my birthday. We ordered the chicken plate, barg, and dill rice with lamb shank (baghali polo). The rice was the highlight of our pleasant trip to Heidar Baba. It was so fluffly and tasty that it just melts in your mouth. My fami... "
The Royce(02/08/2011)
"Spectacular space, beautiful presentation, great service"
OISHII - Thai/Japanese Cuisine & Sushi Bar and Grill(11/07/2010)
"I had eaten here before, under previous owner. The Pad Thai is not as good as before; it was dense, gooey and pastey, and it gave my tummy a "sick" feeling. The rice and food portions have dramatically shrunk, as have the size of the thai tea. The banner outside says "sushi 50% off". Of course ... "
Domenico's Italian Restaurant(10/17/2010)
Mc Murphy's Tavern(10/02/2010)
"The atmosphere/set-up & entertainment is great & the food is very tasty, but the service is terrible. Even with very few people there, it took a long time to get my order. Everyone's order @ my table was wrong when it was received (if it was received), so I had to keep reminding the waitress, "I'm ... "
Indian Restaurant(01/24/2010)
"Best indian food I've had in pasadena."
"We have eaten at Gales for years and find it our favorite. The owners are absolutely wonderful as is the food."
"I'm responding in particular to the fairly recent very grumpy one-star review. I think this is the kind of place where the better you are, the better the experience is. Meaning? Well,it's not a chain, so some nights the service is really personal, charming (these darn Frenchmen!) and caring, and ... "
"Starting with Rene the French husband of Gale; he is the Maitre De. A great guy gives the kiss on each cheek to my wife and a sincere handshake with me. Not phony; a sincerely friendly man. Food is great ,small bar is homey filled with regulars. Good servers especially one particular waitress a pet... "
Sitar Indian Cuisine(11/13/2008)
"I had dinner here tonight and was surprised. My friend who works at the Pasadena Playhouse recommended it to me. I went with my friend and we were greeted my this very nice young man. He seated us by the window, I like that there is still some restaurants that offer booth seating. There looked... "
Burrito Express(11/06/2008)
"Burrito express, will you marry me? Forget all the haters below. They say you aren't "real Mexican." But, do you know what? They aren't real "real Mexican." They're just real jerks. Bean and Cheese. Chicken. Keep it simple and keep it real, Pasadena. Courtesy of Bri B"
Rock Island Wraps & Coffee(05/23/2008)
"The wraps are very tasty and fresh. My favorites are the Caliente Express and Humus Express. The chicken is very lean and flavorful. If you don't want a wrap you can get a chicken plate with a side item and humus. The food is pretty healthy, fresh, and reasonably priced, and for this kind of pla... "
Sitar Indian Cuisine(05/22/2008)
"I normally don't write negative reviews but I was highly disappointed with this restaurant. While the food was average in taste, it was disappointingly stingy in quantity and value. I paid $12 for about a dozen small chunks of chicken tikka marsala, on a large bed of raw onion which was obviously tr... "
"I've eaten here on 3 occasions. First 2 times were good food but average service. The flat iron steak lunch special with asparagus and portobello mushrooms in balsalmic vinegar is really good. However on our 3rd visit we went in around 4PM for an early dinner. Just us a few couples leftover from lun... "
"Excellent shabu-shabu served by an engaging chef. We would recommend this restaurant to anyone who loves authentic Japanese food. Certainly ranks with far more expensive restaurants we have dined in. Food is always fresh, pleasingly served, and subtly spiced."
"First experience: good food, tried one of the specials. was seated on an uneven table by the entrance. waiters were hard to find even though we were eating an early dinner. Second visit: ordered off the daily special but was not impressed. food does taste fresh though. again, waitress was not seen a... "
"The food was mediocre, over-priced, and the service was lacking. Our server was inattentive, forgot our salads, and never refilled our waters! We were choking on our dry food. Needless to say, it ruined a special occasion. Avoid at all costs!!!"


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Lockheed Martin (LMT)
Lockheed Martin (LMT), which reported earnings on Thursday morning, beat the Street on the top and bottom lines — despite the fact that its fourth-quarter profit was 19% lower than a year earlier. Earnings of $2.38 per share easily topped the consensus $2.11, while revenue of $11.53 billion trumped the $11.34 billion forecast.
That's not bad for the largest pure-play defense stock — and it illustrates the value of LMT's relentless cost-cutting efforts. The defense bill helped LMT in two important ways:
First, the troubled and pricey F-35 Lightning II fighter emerged largely unscathed for 2014 and 2015. The bill funded 68 of the sophisticated fighter jets over the next two years and maintained the total order at 2,443. Second, the bill earmarks $333.5 million for a new Air Force search and rescue helicopter — a joint venture between LMT and Sikorsky was the sole bidder on the program.
With a $48.8 billion market cap, LMT trades at 15 times forward earnings and has a price to earnings growth (PEG) ratio of 2.27, which is in line with most other defense stocks. Its current dividend yield is the highest among the top six defense stocks at 3.5%.


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Daily Bagel: Inside the combination of Sloane Stephens and Paul Annacone
The Daily Bagel is your dose of the interesting reporting, writing and quipping from around the Internet.
• Video: TennisTV selects their top five ATP matches of the season.
• Peter Bodo looks at the intriguing combination of Sloane Stephens and Paul Annacone.
Coaches often must be adept at amateur psychology, even with the very best players. [Pete] Sampras had a tendency to want to beat guys at their own games, but Annacone always wanted him to go out and dictate with that explosive game -- "Show them that you're Pete Sampras and they're not."
Stephens needs a measure of that sort of support; every player does, and more often more than you might think. Yet I don't see Stephens as a player who needs a lot of stroking. Drama queen? Yes. Needy? Not so much. Annacone would not make a very good Svengali, so it would be a good thing if his charge didn't expect him to be one.
In fact, the things Stephens most seems to need are the ones Annacone is good at providing. Those include a sound, practical grasp of strategy and tactics. Given Stephens' degree of power, she's been a very instinctive player -- to her detriment, I think. She's often been too content to react to what her opponent is doing, rather than taking charge. And she's suffered some puzzling lapses of concentration.
• A phenomenal tennis quiz put together by Canada's Tom Tebbutt. Good luck!
• Juan Martin del Potro has been named Argentina's Sportsman of the Year for the second time in his career.
• More year-end nostalgia: The BNP Paribas Open blog puts together their fan awards.
• The ATP finishes its countdown of the biggest comebacks of the season.
• No Australian Open comeback for Jelena Dokic.
• Andy Murray is the overwhelming favorite to win the BBC's Sports Personality of the Year, but he won't be attending the ceremony. Apparently this is a big deal.The Big Picture The world mourns Nelson Mandela


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Sep 28, 2012 - StaffLeRoy and Cynthia Griewahn, of Riverton, are pleased to announce the marriage of their daughter Kaya Griewahn, of Riverton, to Brandon Reed, of Riverton. The groom is the son of Russell Reed, of Portland, Ore., and Jodi Reed, of Riverton.
The bride is a 2005 graduate of Riverton High School. She is employed by First Interstate Bank.
The groom is a 2003 graduate of Mandarin High School in Jacksonville, Fla. He is employed by Yeates Construction.
The wedding was Aug. 11, 2012, at the Museum of the American West of Lander.
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by Staff Writers
Karachi (AFP) June 21, 2013
Raymond, an Indian suiting and fabrics conglomerate, will on Friday formally open its first shop in Pakistan, where business leaders welcomed it as a step towards closer trade ties between the two nuclear rivals.
NexSource Pakistan, which acquired the rights to sell Raymond suiting in Clifton, one of the most upscale neighbourhoods in business capital Karachi, said it was a major acquisition.
"They wanted to bring Raymond to Pakistan and we offered to be their partner," said one of its directors, Najmus Saqib.
Nexsource say they expect to reap good business after an aggressive advertising campaign in a city whose wealthier residents are sartorially obsessed and where fashion is a key driver of business.
"People are crazy about clothing and dressing, and they already know Raymond," Saqib said. "We just have to let them know that it is here."
India and Pakistan have fought three wars since independence from British rule in 1947 and relations are traditionally strained.
New Delhi broke off peace talks with Islamabad after Pakistani gunmen killed 166 people in Mumbai in 2008. But lower-level talks have since resumed, focusing largely on trade and visas.
New Pakistani Prime Minister Nawaz Sharif, who is one of the country's wealthiest businessmen, has called for closer rapprochement with India since winning general elections in May.
Both sides have been engaged in deadly exchanges this year across the unofficial border in Muslim-majority Kashmir, which is held in part by each country but claimed in full by both.
On Wednesday, Pakistani officials said a Pakistani girl was killed when Indian troops opened fire.
However NexSource executive Saqib said he believed the enormous Indian market represented massive business opportunities for Pakistan.
"We expect a good response (through Raymond) but we believe it is a futuristic investment as we can explore a market 10 times bigger than ours," said Saqib.
Pakistani business leaders welcome the arrival of the Indian brand, which was founded in 1925 and whose Karachi shop is to be inaugurated formally later on Friday.
"As long as there is healthy competition we welcome this move," said Amin Hashwani, president of the Pakistan India Business Forum.
Nexsource say they plan to open more Raymond outlets in Islamabad, Lahore and Faisalabad before the end of the year.
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Budapest Maria Hostel
Facilities Map Streetview Reviews
Maria utca 7
Note: It is the responsibility of the hotel chain and/or the individual property to ensure the accuracy of the photos displayed. Travellerspoint is not responsible for any inaccuracies in the photos.
Maria Hostel is located in the center of Budapest. You will find plenty museums, bars, restaurants, shops, etc, within walking distance. You will find the best public transport lines in Budapest nearby: Metro 2 - red line, Metro 3 - blue line, buses, trolleys and trams.
Our place offers you a pleasant stay with 2, 3 or 4 bedded rooms. Some are with own, and some with shared showers and toilets. Maria Hostel offers you a big common room with TV, kitchen, and not least a friendly staff and non-stop reception.
Don't forget: central location with great prices! The check out time is at 10 o'clock (luggage storage at the reception) and the check in is after 13:00.
Location: Surrounded by four main squares: Astoria, Blaha Lujza, Klvin and the intersection between the main ring-road and Ulloi street, it is in a walking distance from main pedestrian streets and most frequented places of Budapest.
The area. Things to see and do:
Just a few steps, turn right on Krdy street and try to decide between Darshan Courtyard with Caf, Shops, Restaurant and the old Blues Pub. But just a few more steps away and you'll get to the Mikszth K. square with the Frank Zappa Caf and it's terrace. Five more minutes walking and it's getting almost impossible to choose Rday street, Vci street, Budapest's Main Market, Gellrt baths and so on.
If this is not enough for you, just ask our receptionists about available tours to do. You'll have to choose again You may explore walking, biking, boating or the easy way going by bus. And if all of this is still not enough try the tandem parachuting or the caving tours under Budapest.
Have you stayed here? Write a review
Note: It is the responsibility of the hotel chain and/or the individual property to ensure the accuracy of the photos displayed. Travellerspoint is not responsible for any inaccuracies in the photos.
Create your own travel plan and bookmark this hotel on your plan. You can even bookmark hotels found on other websites!
Do you have questions about Budapest? You might try asking in our active travel forums and see if anyone else has been there.
Read up on what to see and do in Budapest in the Travellerspoint guide, written by travellers for travellers.


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Labor MP
With foreign workers front and centre of the political debate after the government's crackdown on 457 visas, Mr Rudd told a population summit in Melbourne on Thursday that population, participation and productivity were "the three key drivers of the economic future of our nation''.
Mr Rudd, who landed in hot water as prime minister when he advocated a "big Australia'', said the nation's birthrate of 1.89 babies per woman was still below the replacement rate of 2.05 and it had long been offset by "our orderly migration program''.
"Successive generations of migrants from all corners of the world have made Australia much stronger and richer than we otherwise would have been,'' he said.
Had "we simply shut the door after World War II, the population today would be stagnating at around 8 million".
"Whereas instead we have managed to become the 12th largest economy in the world, a member of the G20, whose summit we will host in Australia next year, by far the most significant international gathering of heads of government ever held in our nation's history,'' he said.
Mr Rudd said infrastructure was critical to all three drivers of growth and it was "entirely appropriate'' that Prime Minister
"We have heard nothing from the alternative government of Australia about its plans to tackle the national infrastructure deficit,'' he said.
"Other than in the case of the NBN, where Mr Abbott has committed to simply rip it up, possibly lay out fibre optic [cable] to the node if you happen to live in the right place, not to all premises as we plan, thereby leaving the problem once and again for someone else to fix,'' he said.
Ms Gillard's strong rhetoric on foreign workers – she has vowed to put Aussie workers first and send "foreigners'' to the back of the queue – has alarmed many within her own party and beyond who believe it is directed at more than just the 457 visa program.
Ms Gillard, in two separate radio interviews on Tuesday, said her "concern" around 457 visas was that Australia had failed to provide the education and training for Australians to match the needs of the workforce.
"I want to see us as a country with a world class training system," Ms Gillard told radio station 2UE on Thursday.
Her comments have attracted the support of former One Nation Leader
The Australian Financial Review


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Several white-tailed sea eagle chicks have been released into the wild from a secret location in Scotland.
The huge birds of prey are being re-introduced in Fife after almost being being hunted to extinction in the area.
Sea eagles are known as flying barn doors because they grow to be so huge, but the birds have still been tagged so experts can keep track of them.
They were collected as chicks from nests in Norway and raised in special aviaries before their release.
Clair Smith, from RSPB Scotland, said she was keen to see how this year's birds get on with those from last year.
"From the time these chicks were collected in Norway and brought over to Scotland in June, I've watched them grow up and now they're raring to go.
"I'm really excited to see where they go and if they'll meet up with last year's birds."


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House of the Week: And the Winner Is…
Four new properties vied for the title of "House of the Week." Watch this video (or see the slide show) to find out which home won the most recent readers' poll. The contenders were:
A Take on Tuscany in Pacific Palisades: A stone-clad facade and rustic finishes blend with high-tech audio and a sizable pool area in this Italian-influenced home.
A Puppeteer's Former Playground in the West Village: Once home to puppeteer Bil Baird's marionette theater, this building includes a sunny floor-through apartment that is on the market.
Peak Living in California: A climbing enthusiast chose this hillside home for its sweeping mountain and valley views.
A Southwestern Artistic Oasis: The owners built their dream home—a Pueblo Revival—to soak in the landscape of New Mexico.


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Charlotte Sabean and 40 friends filled council chambers at Digby town hall on Dec. 16 to talk about taxes and more public engagement.
Digby's mayor, town council and staff listened to an hour of comments and questions about the draft of the 2014/15 operational budget for the town.
The town had presented the budget publicly on June 12 and council asked the public to come back five days later with questions and comments.
About 25 residents showed up Tuesday night, June 17 at the Digby Fire Hall, some of whom just listened, and several of whom had pointed questions about the town's finances.
Charlotte Sabean not only attended but also emailed in a list of questions in advance, as the mayor had suggested people do.
Sabean asked specific questions about particular lines in the budget including the salaries of all town staff.
She also asked about the salaries paid to council ($14,000 for a councillor and $20,000 for the mayor).
The mayor pointed out that council had never had a raise, not even consumer price index, since the change from honorariums in 1999.
"I was thinking decrease," said Sabean. "I go to all these meetings, for free, with a four-month old baby."
At the end of the meeting, just before the mayor gave his closing remarks, Sabean asked to give a statement.
"We want council to look at this budget again and cut five per cent off it," she said. "It doesn't matter to us so much where you find the cuts, but we need to pay less taxes not more."
Sabean said later she was pleased with the public engagement process.
"I was happy they gave us the opportunity to ask questions," she said. "It was a short time to review the budget though.
"I thought Ben did a great job at keeping everyone on topic and I was glad Tom replied to my email and everyone seemed to have the answers to the questions.
"I hope the council looks at our suggestions. We really hope they look at the budget closely. We feel there are ways to cut and do things more efficiently."
Sabean says council does a lot of work and should be paid.
"We don't mind that they get paid for their service," she said. "I think it does come down to communication again if people questions what they do. Tell them. I think we are slowly moving in the right direction."
Another resident asked, for example, why the town doesn't schedule its snowplow operators to work shifts to cut down on overtime.
Matthew Raymond, the town's Director of Finance, says they have looked at that question– to have people on shifts all winter would require more staff.
"With wages of more than $900,000 and only $32,000 in overtime, we've done our best to manage it and I don't know if there's anymore we can save there," he said.
Some town residents were shocked to learn that taxpayers pay for a staff Christmas party.
Paul Saulnier was another resident with several comments and questions, mostly about the town cutting expenses to reduce the tax burden.
Still he was happy about the public engagement process.
"I want to congratulate council for the street you've started to walk down tonight," he said. "If you continue this and people see that our comments matter, I think over the years, more and more people will participate."
The mayor says, for his part, he thought the public engagement process went well and council does intend to continue with it.
"Over the next two yeas, we will be getting the budget done earlier, and the public engagement will be earlier and I look forward to hearing more from people as we move forward."
The mayor says staff made notes of all the comments and the councillors were all present to hear.
"Now we will take that information into our deliberations on June 30," he said.
He said the public is welcome to attend and listen to the meeting Monday, June 30 at the townhall at 6 p.m. but the meeting is for council to discuss the budget and possibly vote to approve it.
He said if any of the councillors want changes made or have suggestions, that meeting is the time to bring them up.
Council has also tentatively scheduled July 7 as an extra day for budget deliberations if necessary.
The mayor says council is hoping to have the budget approved by mid-July at the latest.


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Center for Boys and Men Open for Collaboration
May 6, 2013
The College of Health and Human Development has launched its Center for Boys and Men, a research and community outreach effort to address the mental health and other service needs of males. The center's open house April 15 introduced founding directors David Shepard and Rebekah Smart, associate professors of counseling and Matt Englar-Carlson, professor of counseling. Approved last summer, the center has opened and is actively seeking partnerships with scholars across campus and community organizations in areas related to the psychological well-being of boys and men. For more information about the center, contact Englar-Carlson, 657-278-5062.